Kornimate/medical-research-clean huggingface dataset:
effects of vitamin d3 supplementation on cognitive function in community dwelling older adults

Conditions: Healthy

Summary: ireland is predicted to have the highest older adult population growth of any european union country. a substantial economic and social challenge of this projected growth is the increased incidence of cognitive impairment and the likelihood of progression to dementia. dementia's, such as alzheimer's disease, typically have a long prodromal stage with brain changes identifiable from the earliest stages of neuropathology, providing an opportunity for intervention. switching to a strategy of earlier identification and prevention would significantly reduce prevalence and the associated cost. the purpose of this pilot study is to evaluate the use of vitamin d supplements in community dwelling older adults as a lifestyle approach that may support cognitive and physical functioning. the research will incorporate several stages including an initial in-depth screening process, a novel and sensitive cognitive battery, 6 month double blind placebo controlled intervention of vitamin d3 (cholecalciferol) and a concluding participant feedback interview. these results will be used to assess the feasibility of recruiting and assessing community dwelling older adults for extensive nutrition related cognitive studies.


Eligibility criteria:
inclusion criteria: * community dwelling healthy volunteers * ability to provide written consent. exclusion criteria: * measures low or high serum vitamin d, defined as \ 125nmol/l * current use of supplemental vitamin d ≥800 international units/d * screen positive for cognitive impairment using the telephone cognitive screen (tcogs) * measured hypercalcaemia, defined as corrected serum calcium \> 2.7nmol/l * hyperparathyroidism * epilepsy * stroke * renal disease * schizophrenia * bipolar affective disorder * recurrent psychotic depression * alcohol and drug abuse within the past 5 years * anti-convulsants * anti-psychotic medications * significant hearing difficulties even when wearing hearing aid * illness that caused permanent decrease in memory or other mental function

Keywords: vitamin d supplementation cognitive function physical function successful ageing prevention cholecalciferol dementia muscle mass
which is better to start with dpp-4 inhibitors or sglt-2 inhibitors in egyptian diabetic patients?

Conditions: Diabete Type 2

Summary: our trial goal is to determine the efficacy and safety of sitagliptin in comparison with empagliflozin in type 2 diabetic egyptian patients.


Eligibility criteria:
inclusion criteria: * type 2 male/female diabetic patients * age 20-70 years * a1c less than 10.5% exclusion criteria: * type 1 diabetes; hba1c \> 10.5% * pregnancy * chronic liver disease * elevated (more than twofold the upper limit of normal) alt, ast and cpk. * high bilirubin * albumin \< 3.5 g/dl * inr \>1-2 diabetic ketoacidosis * urinary tract infection (uti) * pancreatitis \< 6 months prior to enrolment * renal impairment (creatinine clearance ≤50 ml/min) * treatment with anti-obesity drugs or glucagon-like peptide-1 receptor agonists (glp-1ras) 3 months prior to enrolment * non-compliance with follow-up visits.
effect of dexmedetomidine on the inflammatory response after one-lung ventilation

Conditions: Lung Cancer

Summary: the postoperative inflammatory response is significant in lung resection surgery because of major operation and one-lung ventilation. dexmedetomidine has been shown to reduce pro-inflammatory cytokine levels and improve clinical outcomes. the aim of this study was to determine the effects of dexmedetomidine on inflammatory responses after lung resection surgery.


Eligibility criteria:
inclusion criteria: * elective video-assisted thoracoscopic surgery (vats) lobectomy * 20 \< age \< 75 * american society of anesthesiologists (asa) classification i\~ii exclusion criteria: * preoperative inflammation (crp\>10ng/#, wbc\>10,000/mm3, body temperature \>38#) * steroid administration within 1 month * hematologic / autoimmune disease * congestive heart failure (nyha class iii\~iv) or significant arrhythmia * severe obstructive / restrictive pulmonary disease * previous history of thoracic surgery
use of reticulocyte ratio and neutrophil / lymphocyte ratio in the diagnosis of ventilator-associated pneumonia

Conditions: Ventilator-associated Pneumonia (VAP)

Summary: in this study, the utility of changes in the ratio of ret-he and nlr as an early inflammation marker for vap will be evaluated.

ventilator-associated pneumonia (vap) is one of the most common nosocomial infections in the intensive care unit, affecting one third of patients requiring mechanical ventilation for a noninfectious reason. in the case of inflammation, iron retention increases in the reticuloendothelial system cells; hemoglobin (hb) synthesis is reduced. it has been reported that the ratio of reticulocyte / hemoglobin (ret-he) decreases in the early period in community-acquired pneumonia patients and may be a guide as a marker of inflammation. in addition, the neutrophil / lymphocyte ratio (nlr) is a parameter studied in the hemogram panel. it provides a clue to both the presence of infection and the focus of the infection. in this study, the utility of changes in the ratio of ret-he and nlr as an early inflammation marker for vap will be evaluated.

Eligibility criteria:
inclusion criteria: -patients who need mechanical ventilation for longer than 48 hours for a noninfectious reason in the intensive care unit exclusion criteria: * pulmonary or extrapulmonary infection before mechanical ventilation, * severe immunosuppression, * bleeding in the gastrointestinal system, * using corticosteroids, * neoplastic disease history

Keywords: ventilator-associated pneumonia reticulocyte/hemoglobin ratio neutrophil/lymphocyte ratio
pla for hcc and esophageal ca serum

Conditions: Hepatocellular Carcinoma; Esophageal Cancer

Summary: the primary goal of this study is to quantify the biomarkers of pre-radiation therapy(rt), during-rt, and post-rt serum samples from hepatocellular carcinoma (hcc) and esophageal cancer patients undergoing definitive or neoadjuvant rt, and to correlate them with tumor response, patterns of failure, survival outcome, and rt-related lung or liver toxicity. the secondary goal of this study is to set up the pla platform in our institute for future biomarker test.

there have been many biomarkers, such as angiogenesis factors and cytokines, related to cancer progression or microenvironment interaction. however, the commonly used enzyme-linked immunosorbent assay (elisa) requires the certain volume of each sample for specific antigen or antibody. it may not be practically efficient to test a broad spectrum of biomarkers with limited volumes of serum from cancer patients. proximity ligation assay (pla), an established concept and platform requiring very little sample volume to quantitatively detect a variety of biomarkers, is being developed with multiplex versions of improved sensitivity and dynamic range by the stanford group. from the three completed trials ("in vivo/vitro radiation-induced liver disease in hbv carrier（9261700196）", "bystander effect study of radiation-induced viral hepatitis b reactivation（9261700196）", and "pre- and post-chemoradiation blood rna-microarray analysis to predict response and outcome of locally advanced esophageal squamous cell carcinoma（200805061r）") and one ongoing trial ("a phase i dose escalation trial of conformal hypofractionated radiation therapy for patients with hepatitis b virus-related child a cirrhosis and hepatocellular carcinoma（200906051r）"), we have collected the pre-treatment and post-treatment serum samples of patients with hepatocellular carcinoma undergoing definitive radiotherapy and patients with esophageal cancer undergoing neoadjuvant chemoradiotherapy. altered patterns of failure for post-radiotherapy hepatocellular carcinoma, especially intrahepatic and extrahepatic metastasis, and treatment response for post-chemoradiotherapy esophageal cancer upon esophagectomy, demands the effective biomarkers for the early prediction and appropriate management. the limited sample volumes form the obstacle of testing adequate number of biomarkers by elisa. in this study we plan to collaborate with the stanford group, to send and process these samples (100 μl each) to measure the dynamic changes of up to 56 or more biomarkers. we try to find the potential biomarkers correlating with treatment responses and patterns of failure for the future clinical practice, and wish to set up this viable pla platform in our institute through this collaboration.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of locally advanced esophageal cancer or hepatocellular carcinoma, rt is indicated * informed consent signed exclusion criteria: * not completed rt
evaluation of a diagnostic feature in a cardiac resynchronization therapy (crt) device

Conditions: Congestive Heart Failure

Summary: the purpose of this study is to evaluate the performance of a new sensor-based diagnostic feature, which has been implemented in a cardiac resynchronization therapy (crt) device. this trial will study the effectiveness of the diagnostic feature to detect heart failure events in medically stable, icd-indicated, congestive heart failure patients.

the purpose of this study is to evaluate the performance of a new sensor-based diagnostic feature, which has been implemented in a cardiac resynchronization therapy (crt) device. this trial will study the effectiveness of the diagnostic feature to detect heart failure events in medically stable, icd-indicated, congestive heart failure patients. the ability of the diagnostic feature to 'detect' and 'predict' heart failure events will be studied.

Eligibility criteria:
inclusion criteria: * subject eligible for implantation of a crt-d device according to current available guidelines for cardiac resynchronization therapy * subject has severe heart failure (nyha class iii or iv) * subject has experienced at least one heart failure event within six months prior to enrollment * subject continues to have heart failure symptoms despite receiving optimal medical therapy * schedule for implant of a paradym crt-d (model 8770) * subject has signed and dated an informed consent form exclusion criteria: * any contraindication for standard cardiac pacing * any contraindication for icd therapy * abdominal implantation site * hypertrophic or obstructive cardiomyopathy * acute myocarditis * unstable coronary symptoms (unstable angina or myocardial infarction) within the last month * recent (within the last month) or planned cardiac revascularization or coronary angioplasty * correctable valvular disease that is the primary cause of heart failure * mechanical tricuspid valve * receiving continuous intra-venous infusion of positive inotropic therapy or intermittent therapy (intravenous infusion) more than twice per week * heart transplant recipient * renal insufficiency requiring dialysis * already included in another clinical study * life expectancy less than 12 months * inability to understand the purpose of the study or refusal to cooperate * inability or refusal to provide informed consent or hipaa * unavailability for scheduled follow-up at the implanting center * known sensitivity to 1mg dexamethasone sodium phosphate (dsp) * under guardianship * age of less than 18 years * pregnancy

Keywords: nyha class iii or iv implantable cardiac defibrillator cardiac resynchronization therapy
a nutritarian study to evaluate the effectiveness of lifestyle changes in chronic disease prevention, especially cancer

Conditions: Chronic Disease; Cancer; Cardiovascular Diseases; Diabetes Mellitus; Lifestyle-related Condition; Mental Health Wellness 1; Sleep; Nutritional and Metabolic Disease; Nutrition Related Cancer; Nutritional Imbalance; Thyroid

Summary: the nutritarian women's health study (nwhs) is a long-term hybrid effectiveness-implementation study on the effect of the nutritarian diet on the occurrence, recurrence, and progression of chronic diseases (including all forms of cancer and cardiometabolic risk factors).

the nutritional research foundation, in conjunction with northern arizona university, is conducting a long-term health study for women ages 18 and older. this study will address the effects of a nutrient dense, plant-rich diet on the long-term risks of cancer and other chronic diseases. participants enroll in a 30-day training module which outlines the benefits of a nutrient-dense, plant-rich diet. at the conclusion of those videos and written modules, they take a short quiz to assess their knowledge and they can enroll in the full study. all participation is online with ongoing modules on nutrition and lifestyle. there is a comprehensive health history and lifestyle index to be completed. nutrition questionnaires will be administered an average of every 3-6 months; phq-9 (patient health questionnaire) \& psqi (pittsburgh sleep quality index) questionnaires an average of every 12 months; serum cardiometabolic measures and liquid biopsies an average of every 18 months.

Eligibility criteria:
inclusion criteria: * women only * age 18 years and older. * must be willing to complete an online program * follow the dietary guidelines as outlined to the best of their ability. * english-speaking * us residents * have internet access * pregnant women are eligible exclusion criteria: * none
the effect of active nutritional support on quality of life in patients with head and neck cancer receiving radiotherapy

Conditions: Head and Neck Neoplasms

Summary: note effect of appropriate nutrition on head and neck cancer patients receiving radiotherapy

head and neck cancer (hnc) is the sixth most common cancer worldwide with more than half a million new cases diagnosed each year . because of the limitations imposed by the complicated anatomical structure of the head and neck to the operation, radiotherapy (rt) has become the main treatment method for hnc. however, damage to the normal tissue surrounding the tumor is inevitable. the most common manifestations of injury caused by rt are mucositis with the dry mouth, loss of taste, and dysphagia. the severe dysphagia leads to a definitive total impossibility of eating through the mouth in 20-30% of patients. radiation-induced oral mucositis (riom) is a common side effect after radiotherapy (rt) in head and neck cancer (hnc) patients. riom patients with severe pain have difficulty in eating, which increases the incidence of malnutrition and affects patients' quality of life and the process of rt.

Eligibility criteria:
inclusion criteria: * head and neck cancer patients with age \>18 * newly diagnosed head and neck cancer patients * histological proven hnc cancer * head and neck cancer patients treated with radiotherapy or chemo radiotherapy exclusion criteria: * advanced and metastatic head and neck cancer patients * head and neck cancer patients treated with chemotherapy only
a novel objective diagnostic test for otitis media with effusion

Conditions: Otitis Media With Effusion

Summary: otitis media with effusion (ome) cases refer to a clinically silent condition. otoscopic findings are subjective and not always reliable. as an objective test tympanometric evaluation is imperfect for diagnosis of ome. the objective of our study was to investigate, in ome cases, the correlation of tympanic membrane color changes with the presence and viscosity of effusion in the middle ear. the study aimed to provide objective diagnostic and therapeutic criteria for patients scheduled for surgery by 2 means: measuring the viscosity of the fluid and evaluating color changes objectively with red-green-blue (rgb) measurements.

endoscopic images of the tympanic membranes of 52 patients (group 1) and 52 healthy controls (group 2) were taken during their otologic examinations. all patients in group 1 had hearing loss and were diagnosed with ome after audiological evaluation. specific points were designated at certain areas on each tympanic membrane, and rgb values of those specific points were measured on the tympanic membrane images of both groups. additionally, in group 1 viscosity of each effusion taken by paracentesis during surgery was also measured intraoperatively with a viscometer. patients with viscosity values lower than 450 cp (centipoise) were subdivided into group 1a, and those with values higher than 450 cp into group 1b.

Eligibility criteria:
inclusion criteria: * patients with ome, that had endoscopic-otoscopic examination findings and type-b tympanograms. * they were all scheduled for ventilation tube insertion. exclusion criteria: * patients presenting with acute otitis media, tympanosclerotic plaques, mental retardation, and children who were difficult to cooperate with.

Keywords: otitis media with effusion, viscosity, rgb (red-green-blue).
prediction and prevention of preeclampsia by first trimester ultrasound

Conditions: Preeclampsia

Summary: the purpose of this study is to determine whether the fetal medicine foundation algorithm for individual risk calculation for preeclampsia (pe) and pregnancy induced hypertension (pih) is suitable to identify women in high risk of developing these diseases in a norwegian population.

it has been shown that low dose acetylsalicylic acid (asa) in pregnancy reduces adverse outcome of pregnancy in women that have high risk of developing preeclampsia (pe). it is a challenge for the clinician to identify the high risk women. doppler blood flow measurements in uterine arteries in second trimester have been shown useful to predict the development of the disease but prophylactic treatment with asa from this point in pregnancy has not been proven effective. fetal medical foundation has developed an algorithm that calculates individual risks for pe/ pih based on doppler blood flow measurements and anamnestic information.

Eligibility criteria:
inclusion criteria: * pregnant * nulliparous * para 1+ with previous preeclampsia or gestational hypertension * last menstrual period (lmp) pregnancy length at inclusion \< 13 weeks * residence in trondheim + 8 surrounding municipalities exclusion criteria: * pregnancy length \> 13+6 weeks (crl \> 85 mm) * twins * missed abortion * fetal anomaly

Keywords: preeclampsia doppler ultrasound first trimester acetylsalicylic acid
psychological profile of women with infertility in egypt: a comparative study

Conditions: Infertility

Summary: the aim of this study is to determine the prevalence of psychological affection in infertile egyptian women

comparative cross sectional study

Eligibility criteria:
inclusion criteria: control group: * pregnant women. * at least one live birth. * age group 20-40 years. clinical group: * infertile women either primary or secondary according to (who,2013). * age group 20-40ys. * different levels of education. * different methods of treatment of infertility (medical or ivf) * half of them from rural area the other half from urban area. exclusion criteria: * male factor of infertility. * the women with psychiatric disorders. * the women with physical and medical disorders. * the women whose current pregnancy has any problems (e.g. growth retardation, macrosomia, placenta previa, threatened abortion, or preterm labour). * the women with history of intrauterine fetal death.

Keywords: psychological health women anxiety depression
the therapeutic effect of tbs stimulation on emotion regulation in autism spectrum disorder

Conditions: Autism Spectrum Disorder

Summary: the investigator would like to investigate the impact of intermittent theta burst stimulation over left dorsolateral prefrontal cortex on emotion regulation in autism spectrum disorder


Eligibility criteria:
inclusion criteria: * autism spectrum disorder, confirmed by ados exclusion criteria: * previous or current severe neurological disorder such as epilepsy, visual or hearing impairment * previous or current severe systemic disease such as cardiovascular disease, diabetes or infection * previous or current severe brain injury * implementation of metal materials such as pacemaker or medication pump * previous or current severe psychiatric disorders such as schizophrenia, bipolar disorder or substance abuse * pregnancy * individuals with a significant brain abnormality such as intracranial space occupied lesions * individuals with a family history of epilepsy * previous febrile seizures * current taking antiepileptic drugs * concurrent use of medications which increased the risk of seizure attack * individuals suffering from sleep deprivation during rtms procedures * skin trauma on application site * any condition which in the investigator's opinion deems the participant an unsuitable candidate to participate in the study * participate another clinical trial within one month
understanding the acute pain phenotype in patients undergoing surgery

Conditions: Acute Pain; Chronic Post Operative Pain; Opioid Use

Summary: the goal of this observational study is to learn about how regional anesthesia (numbing medication) affects pain in patients with different psychosocial phenotypes such as different levels of concern about pain, sleep issues, and anxiety, who are having surgery. the main questions are: 1. do psychosocial factors such as concerns about pain, sleep, anxiety affect the effectiveness of regional anesthesia? 2. do psychosocial factors and regional anesthesia affect the amount of opioids used after surgery? 3. do psychosocial factors and regional anesthesia affect development of chronic postsurgical pain?

a patient's psychological profile importantly modulates pain severity, and the overall experience and impact of pain. for instance, catastrophic thinking about pain, including magnification, rumination, and helplessness, is associated with both greater pain severity and impact. over the years, regional anesthesia has become an integral part of multimodal pain management for many surgeries. regional anesthesia (epidural and peripheral nerve blocks) to be associated with superior pain control, reduced time to return of bowel function, shorter intraoperative times, fewer side effects and complications, earlier ambulation and functional exercise capacity post-discharge, lower in-hospital mortality, reduced length-of-stay, improved patient satisfaction, and fewer readmissions. the investigators aim to use of validated psychosocial surveys and semi-structured interviews to understand the phenotype of patients who will benefit the most from regional anesthesia. the investigators also aim to understand how different patient phenotypes and regional anesthesia affect perioperative opioid consumption, and development of chronic postsurgical pain.

Eligibility criteria:
inclusion criteria: * age ≥ 18 * english speaking * surgical or procedural patient who will be admitted postoperatively * willingness to answer psychosocial survey and/or audio recorded semi-structured interview exclusion criteria: -cognitive dysfunction that precludes communication

Keywords: regional anesthesia peripheral nerve blocks psychosocial phenotype pain catastrophizing