Kornimate/medical-research-clean huggingface dataset:
lancgms - lantus continuous glucose monitoring subcutaneous

Conditions: Diabetes Mellitus

Summary: comparison of incidence of hypoglycaemic events and glycaemic fluctuations in diabetic patients with basal substitution with nph insuline versus insuline glargine. evaluation of hba1c, fbg (fasting blood glucose), bmi (body mass index), dose of insulin, ratio of basal and prandial insulin, satisfaction with treatment, incidence of adverse events.


Eligibility criteria:
inclusion criteria: * patients with diabetes mellitus type 1 and diabetes mellitus type 2 with hba1c 6% and more with more than 2 confirmed hypoglycaemic events (glycaemia less than 3,3 mmol/l) during last year exclusion criteria: * diabetic ketoacidosis * any other severe disease * pregnancy or fertile female without contraception * alcohol/drug abuse, selected prohibited concomitant medication * nightshift work
nutritional intervention in hip fracture patients

Conditions: Hip Fracture; Malnutrition

Summary: hip fractures are highly prevalent and are expected to increase due to the ageing population. malnutrition is often present in these patients and is associated with prolonged convalescence, lower mobility, lower mental function, lower quality of life and higher complication rate. nutritional intervention starting soon after hospital admission might reduce complication rate and total length-of-stay by improving nutritional and functional status. research questions are: 1. does nutritional intervention reduce total length-of-stay? 2. is nutritional intervention cost-effective? 3. can nutritional screening contribute to targeting of nutritional intervention, and thereby reduce costs without loss of effectiveness? patients randomized to the intervention group will receive oral nutritional supplements (protein and energy enriched) and regular dietetic counselling during hospitalisation and after discharge at patients' homes for 3 months. patients in the control group will receive usual nurse and dietetic care. outcome measurements will be taken at baseline, 3 months and 6 months after inclusion.


Eligibility criteria:
inclusion criteria: * admission to one of the participating hospitals because of a proximal femur fracture * age 55 years and older exclusion criteria: * periprosthetic or pathologic fracture * diseases of bone metabolism, e.g. paget, primary/secondary bone tumors, hyperparathyroidism, m. kahler * life expectation of less than one year due to underlying disease (e.g. cancer) * presence of dementia or other severely impaired cognitive function * inability to communicate in dutch language * nutritional intervention prior to admission * patients who are bedridden * patients who are too ill or for any other reason not able to participate adequately in follow-up

Keywords: elderly osteoporosis hip fracture malnutrition nutritional support
intermittent pneumatic compression to improve revascularization outcome

Conditions: Peripheral Arterial Disease

Summary: the purpose of this study is to investigate whether daily treatment with intermittent pneumatic leg compressions (ipc) following a nonsurgical vascular procedure improves circulation and enhances walking distance.

restenosis following revascularization procedures occur frequently and as early as 3 months after the intervention. there is an urgent need for adjunctive therapies that aid in the improvement of tissue blood flow and consequently relieve pain and improve functional capacity in these patients. it has been previously shown that exposure to ipc enhances leg blood flow to collateral-dependent tissues. in this study, subjects who have undergone nonsurgical revascularization will be randomly assigned to two groups: ipc or placebo pump. subjects will receive a commercially available ipc device (art assist, aci medical, san marcos, ca) and will apply the treatment at home for 2 hours daily over 3 consecutive months. at 3 time points (pre, 1 and 3 months post procedure) assessments will be performed (hemodynamics, rest pain, calf muscle oxygenation during exercise, walking endurance and quality of life).

Eligibility criteria:
inclusion criteria: * at least 18 years of age * scheduled for endovascular revascularization of one or both lower extremities. exclusion criteria: * chronic kidney disease (egfr \<30 by mdrd or mayo or cockcroft-gault formula) * open and/or non-healing wounds in the areas covered by ipc cuff * walking limited by a symptom other than pad * presence of any clinical condition that makes the patient unsuitable to participate in the trial * concern for inability of the patient to comply with study procedures and/or follow-up
maternal newborn health registry

Conditions: Pregnancy Outcome Trends in Low-resource Geographic Areas

Summary: the primary purpose of this population-based study is to quantify and understand the trends in pregnancy outcomes in defined low-resource geographic areas over time, in order to provide population-based data on stillbirths, neonatal and maternal mortality.

the purpose of the global network for women's and children's health research is to develop and test feasible, sustainable interventions to improve the outcome of women and children and to develop research capacity in resource-poor settings. because most of the sites have weak health care systems, unacceptably high rates of maternal and neonatal mortality and lack birth and death registries, they lack precise data on outcomes and measures of care. information from a vital registry system will allow the global network to document maternal and neonatal mortality, design trials to address the major causes of poor outcome, assess the outcome of our interventions, and ultimately disseminate the results as the basis of public health policy. a sub-study to the maternal newborn health registry will be conducted to understand the prevalence of covid-19 among pregnant women, the association between covid-19 and pregnancy outcomes, and the knowledge, attitudes, and practices of pregnant women related to covid-19 and its prevention during pregnancy. women who consent to participation in the mnhr covid sub-study will provide a blood specimen at or near delivery to be tested for covid-19 antibodies. four global network sites (guatemala, bangladesh, nagpur india and pakistan) will also collect and analyze blood specimen from participants during antenatal care visits.

Eligibility criteria:
inclusion criteria: * community-level * appropriate for long-term registry data collection and the conduct of ongoing global network research * at least 300 deliveries per year * participant-level * pregnant women intending to deliver within study cluster * women who deliver within the study cluster * women who reside in the community but are transferred for care at delivery exclusion criteria: * participant-level * opt out of consent to include data in the study

Keywords: pregnancy maternal mortality neonatal mortality stillbirth maternal cause of death neonatal cause of death
choline supplementation and cardiovascular health

Conditions: Cardiovascular Risk Factor

Summary: trimethylamine-n-oxide (tmao), a metabolite produced by gut microbial metabolism of dietary choline, has recently been causally linked to atherosclerosis in animal models and has been shown to be predictive of cardiovascular disease (cvd) risk in some but not all cohort studies. the relevance of observations in animals to humans is unclear and little information is available on the mechanisms linking tmao to increased cvd risk. vascular dysfunction plays a critical role in the initiation and progression of atherothrombotic disease. whether tmao impairs vascular function in humans is not known. the purpose of this study is to determine if acute supplementation of dietary choline, which increases tmao, impairs vascular function.


Eligibility criteria:
inclusion criteria: * 18-65 years old * healthy * non-smoking * weight stable for previous 6 months (±2.0 kg) * bmi \<35 kg/m\^2 * verbal and written informed consent * approved for participation by study medical director (jose rivero, m.d.) exclusion criteria: * smoking * pregnancy * obese (bmi\>35 kg/m2) * altered dietary patterns within the last month of recruitment * unstable heart disease or diabetes * untreated high blood pressure or high cholesterol * allergies to choline * unvaccinated against covid-19

Keywords: choline trimethylamine n-oxide vascular health
determination of specific biomarkers of angioneurotic crisis

Conditions: Angioedema

Summary: diagnosis of angioedema (ae) is difficult especially in emergency room. two forms should be evoked: histaminic ae (allergic or not, which represent 95% of cases) and bradykinic ae (hereditary or acquired deficiency, with or without c1 inhibitor) rarer but with more severe prognosis. the distinction is based on clinical features (spontaneous crisis duration, presence of concomitant hives, atopic history...). sometimes it could be difficult to make the difference. nowadays, there is no biological marker of the crisis. the search for biomarkers could improve the diagnostic and therapeutic management of ae. previous work has identified targets: d-dimer, c4, and ve-cadherin. we wanted to know the sensitivity and specificity of these markers. we conducted a prospective study evaluating the d-dimer assays, complement and ve-cadherin during an episode of ae. three groups of patients were tested: bradykinic ae (peripheral or abdominal attacks), histaminic ae, and abdominal pain (non-bradykinic and non-histaminic etiology) at the time (day 0) and at distance from the crisis (d7).


Eligibility criteria:
inclusion criteria: * histaminergic or bradykinin angioedema * abdominal pain exclusion criteria: * children \< 18 years

Keywords: angioedema c1inhibitor bradykinin histamin
comparative effects of group based exercises with and without cognitive functional therapy on clinical outcomes in patients with chronic low back pain

Conditions: Low Back Pain, Chronic

Summary: 1.1research objective the objective of the study is to find the comparative effects of group based exercises with and without cognitive functional therapy on clinical outcomes in patients with chronic low back? 1.2 hypothesis null hypothesis h0= there is no significant difference of clinical outcomes between the cognitive functional therapy with group exercises and group based exercises only in patients with chronic low back pain. alternative hypothesis h1= there is a significant difference of clinical outcomes between the cognitive functional therapy with group exercises and group based exercises only in patients with chronic low back pain.

background: low back pain is the problem gradually increasing in both young and older adults. it can be specific and non-specific, the specific low back pain is the pain which arises due to any structural or functional disease like due to any mechanical factors, poor posture, improper way of lifting and bending while non-specific low back pain is the pain which have no any known causes. cognitive functional therapy and group based exercises both have beneficial effects to reduce lbp. aims and objectives: the aim of the study will be to find the comparative effects of group based exercises with and without cognitive functional therapy on clinical outcome in patients with chronic low back pain. methodology: this study will be randomized controlled trial. the subjects will be selected through probability purposive sampling.sample will be 40 calculated by the rao-soft with 20 percent chances of drop out. the participants will be taken from mujahid hospital, faisal hospital and madina teaching hospital. participants will be assessed by using oswestry disability index and numerical pain rating scale nprs for low back pain. participants will be randomly allocated into two groups.one group will be treated with cft and group based exercises and one with only group exercises. and at the end, data will be analyzed by using statistical package for the social sciences (spss).

Eligibility criteria:
inclusion criteria: * pain level equal or more than 3 on nprs a score of fourteen percent 14% or more on the oswestry disability index (odi) low back pain for at least 6months duration exclusion criteria: * red flags (neoplastic diseases or cancer in the spine, inflammatory diseases, infections, and fractures) neurological symptoms and psychiatric, rheumatologic, and cardiac diseases radiculopathy with symptoms lumbar stenosis spondylolisthesis history of spinal surgeries pregnancy

Keywords: cognitive functional therapy group based exercise chronic low back
testing the nocturnal sleep latency profile in primary insomnia

Conditions: Primary Insomnia; Sleep Initiation and Maintenance Disorders

Summary: this study tests a new kind of sleep study in which subjects are awakened 2 times after initially going to sleep. the study focuses on the eeg signal process as a person goes to sleep. the general hypothesis is that the signal properties are stable from night to night during baseline studies, and are different between controls and patients with primary insomnia. the primary insomnia patients then go on to have about 2 weeks of an insomnia intervention. then the new kind of study is repeated in the patients. the controls only are examined in baseline studies.

patients are carefully screened to have dsm primary insomnia, and do not have another disorder than may cause a sleep disturbance. after a 2-week baseline period, the subjects undergo a screening sleep study to rule out sleep apnea and periodic limb movement disorder. then they undergo the nslp procedure. in that procedure, there pre-bedtime eeg recordings and questionnaire responses taken. then at a planned time, the subjects go to bed and try to sleep while there eeg signals are recorded. after the first and second sleep cycles, they are awakened for one minute, then asked to return to sleep. in the morning additional recordings and questionnaire responses are obtained. two nights later they repeat a baseline nslp procedure. the controls then end their participation. the patients then receive an open treatment with eszopiclone and behavioral treatments so that their insomnia may improve. after 2 weeks intervention, the patients complete one nlsp night. the goal of the study is to see if there can be data to support the idea that the sleep onset process might harbor a sign of primary insomnia that could be used for the development of a better medical model of primary insomnia.

Eligibility criteria:
inclusion criteria: * primary insomnia (n = 12) age \& gender matched healthy controls (n = 12) exclusion criteria: * unstable medical illness no other sleep disorder bmi \> 35, ahi \> 10, plm index \> 10, ferritin \< 50. unable to communicate in english

Keywords: insomnia polysomnography sleep onset time series analysis
absorbable or non absorbable sutures in hand surgery

Conditions: Wound Complication Hand Surgery

Summary: after all surgical procedures, the skin must be closed with some form of stitch, in healthcare called suture. according to the tradition of hand surgery, sutures that must be removed by caregivers, ie non-resorbable thread, have been used extensively, and the frequency of complications in the form of wound rupture and infection is low. for many procedures, however, it can be an advantage to avoid removing the stitches, as it is both painful for the patient and time-consuming and resource-consuming for both the patient and the healthcare system. you can then use a thread that the body itself breaks down and absorbs, ie resorbable suture. in the project, we will compare resorbable and non-resorbable suture with the primary outcome of superficial infection in the surgical area sometime day 1-20 after surgery. secondary outcomes are the occurrence of wound rupture, pain vas (visual analog scale) when changing 2 weeks postoperatively, patient satisfaction vas at 2 weeks and time spent in minutes for changing at 2 weeks postoperatively. the project will include all consecutive patients\> 18 years of age who are operated on at the hand surgery clinic södersjukhuset for elective or emergency surgery that do not meet the exclusion criteria. the project will include 270 patients.


Eligibility criteria:
inclusion criteria: * all consecutive patients\> 18 years of age who are operated on at the hand surgery clinic södersjukhuset for elective or emergency surgery that do not meet any of the exclusion criteria. exclusion criteria: * -the researcher has an age \<18 years. * patients with known healing problems in the past, for example patients with burns or during cortisone treatment. * patients undergoing surgery where skin grafting occurs. * patients with acute injuries that include a traumatic wound-ie what is usually referred to as "open injuries" -where the risk of infection is higher from the beginning.
the early stockholm obesity prevention project in china

Conditions: Pediatric Obesity

Summary: this is a cohort study where families with infants are followed closely for three years. it aims to assess if parental weight status (normal weight vs. overweight/obesity), their physical activity and eating habit will influence their young children's growth and be helpful in childhood obesity reducing.

the aimed 300 families are invited with half parents in high risk group (one of the parents with bmi\>=28 or both 28\>bmi\>=24) and half in low risk group (both parents with bmi\ bmi\>=24) living in wuhan city. maternal and paternal prepregnancy weight and height are recruited through the children systematic health management system before the child's first birthday. after getting an oral agreement, a later on family visit will be done by trained staffs. the home visit contains anthropometrics measurement, including weight, height, head circumference, abdominal circumference for both parents and children and blood pressure for parents; it also has some questionnaires that have children's condition during the first years, the caring status, parents' characteristic information, the eating, physical activity and sleeping habits for both parents and children, children's seven day 24 hours' sleeping record in the coming week; at the same time, objectively measured physical activity for parents and children will be done for seven days with accelerometers. the annual visit will range 15 days before or after the children's birthday, and this will begin from the children age one and followed up to aged three.

Eligibility criteria:
inclusion criteria: * a child in the household being 1 year old (±3 months) at the time of recruitment; * the parents were wuhan registered residents; * the child had no chronic health condition affecting growth, physical activity or eating habits. exclusion criteria: * none.

Keywords: early intervention obesity body weight body mass index overnutrition early promoters, genetic
high precision imaging of prostate specific membrane antigen for personalized treatment in prostate cancer

Conditions: Prostate Cancer

Summary: this is an investigator initiated, non-commercial, single center, non-randomized, single arm, open label pilot study on 194 patients. the patients are affected by prostate cancer but in two different clinical settings. the first group is characterized by patients who are going to be operated of radical prostatectomy and they will undergo the study imaging preoperatively. the second group experiences biochemical relapse after primary treatment.

novel, sensitive tools, such as 68ga-psma pet imaging, have great potential for very early disease detection and open the possibility of early curative local salvage treatment (with surgery, radiotherapy or a combination of both). this project will moreover provide important insights into the biodistribution and dosimetry of 68ga-psma, opening possibilities of 90-yttrium or 177-lutetium-psma-based radionuclidetherapy of patients with metastatic pc in the future. the study consists of 2 work units (wu): work-unit 1: patients at high risk for nodal involvement prior to radical prostatectomy with extended lymph node dissection work-unit 2: biochemical recurrence after initial treatment with curative intent

Eligibility criteria:
inclusion criteria work-unit 1 * age \< 75 years of age, with histologically proven invasive adenocarcinoma of the prostate * a risk of equal or more than 5% of lymph node metastasis (intermediate to high risk disease), according to the briganti nomogram (1) * scheduled to undergo radical prostatectomy with extended lymph node dissection work-unit 2 * histologically proven diagnosis of prostate cancer * biochemical relapse (two consecutive psa≥0.2 ng/ml) of prostate cancer following radical local prostate treatment * who performance state 0-1 * age \> 18 years old exclusion criteria work-unit 1 * involvement of pelvic lymph nodes assessed by multi-parametric mri * evidence for bone metastasis assessed by bone scan (if psa \> 20 ng/ml) * who performance status \> 2 * previous pelvic irradiation or radical prostatectomy. * other malignancy except adequately treated basal cell carcinoma of the skin diagnosed during the last 5 years * any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule; those conditions should be discussed with the patient before registration in the trial. work-unit 2 * serum testosterone level \<50ng/ml * symptomatic metastases * local relapse on mri * psa rise while on active treatment with lhrh-agonist, lhrh-antagonist, anti-androgen, complete androgen blockade, oestrogen-antioestrogen therapy * previous treatment with cytotoxic agent for pca * treatment during the past month with products known to influence psa levels (e.g. fluconazole, finasteride, corticosteroids,...) * disorder precluding understanding of trial information or informed consent

Keywords: prostate-specific membrane antigen lymph node dissection prostatectomy positron-emission tomography