Kornimate/medical-research-clean huggingface dataset:
mauriac syndrome: isotopic techniques and genetic analysis

Conditions: Diabetes Mellitus; Short Stature; Glycogen Deposition

Summary: mauriac syndrome (ms) is an entity of individuals combining poorly controlled diabetes mellitus type 1, short stature and glycogenic hepatopathy. thus, the functional significance of mauriac syndrome for glucose metabolism remains disputed, and whether genetic defects in glycogen metabolism contribute to glycogenic hepatopathy in ms remains to be clarified.coupling the genetic analysis of targeted genes involved in glucose regulation with a dynamic exploration will eventually determine if a genetic abnormality leads to the disease and explains the nature of the phenotype.

investigation of glucose homeostasis in ms, after an oral glucose load followed by exercise, using a quantitative measurement of the substrate flux. this dynamic in vivo kinetics can be explored using stable, nonradioactive tracers with the help of gas or liquid chromatography. investigation of genetic factors associated with ms phenotype. molecular analysis will be performed by next generation sequencing (exome or whole genome sequencing). in addition, a targeted analysis for pathogenic variants in genes implicated in homeostasis regulation will be done.

Eligibility criteria:
inclusion criteria: * inclusion criteria for controls: * dt1 * \> 18 years old) * presence of at least one of the following auto-antibodies: anti-gad65, anti-iaa, anti-znt8, anti-ia2 or ica and/or low c-peptide * insulin therapy by multiple daily injections or continuous subcutaneous insulin infusion by an insulin pump * informed consent as documented by signature inclusion criteria for subjects: * mauriac syndrome * dt1 * \> 18 years old * presence of hepatomegaly in infancy (confirmed ≥ 1 abdominal us) at the time of diagnosis of mauriac syndrome * presence of short stature during infancy at the time of diagnosis of mauriac syndrome (\<p3; who growth curves on ≥ 2 different measures, at 2 different time-points) * presence of at least one of the following auto-antibodies: anti-gad65, anti-iaa, anti-znt8, anti-ia2 or ica and/or low c-peptide * informed consent as documented by signature exclusion criteria for subjects and controls : * obesity (bmi ≥ 30 kg/m2 or \> 90th percentile) * illness that contraindicates physical activity * women who are pregnant or breast feeding * any clinically unstable disease * myocardial infarcts, syncope, heart rhythm disorder, unstable hypertension in the last 6 months * blood donation in the last 3 months for men and 4 months for women before the study * enrollment in a previous study less than 30 days before the start of the study * participation of the investigator, a family member, an employee or someone having a link with the investigator
correlation between adr of screening and all colonoscopies

Conditions: Colon Neoplasm

Summary: the aim of the study is to compare adr for colonoscopies from various indications and to find correlations between adr of screening and all examinations.

adr (adenoma detection rate) is generally accepted quality indicator and it is calculated from screening colonoscopies in patients over 50 years of age. for possible gaming with adr for screening colonoscopies, monitoring of adr for all colonoscopies is discussed nowadays.the aim of the study is to compare adr for colonoscopies from various indications and to find correlations between adr of screening and all examinations. we want to retrospectively assess the quality indicators of all colonoscopies performed from january 2013 to december 2017. we want to calculate adr for all colonoscopies in patients over 50 years of age excluding therapeutic, ibd, management of complications and sigmoidoscopies (screening, surveillance, diagnostic) and separately only for screening colonoscopies. correlation analysis will be performed using pearson´s correlation coefficient.

Eligibility criteria:
inclusion criteria: * people over 50 years of age coming for colonoscopic examination (screening, surveillance, diagnostic) exclusion criteria: * age under 50 years * indication for colonoscopy: therapeutic, ibd, management of complications and sigmoidoscopies
gentle yoga and dietary counseling in improving physical function and quality of life in stage i-ii endometrial cancer survivors

Conditions: Obesity; Endometrial Carcinoma

Summary: this randomized clinical trial studies how well gentle yoga and dietary counseling lifestyle change effects physical function and quality of life of endometrial cancer survivors. gentle yoga and dietary counseling may help improve physical function and quality of life for stage i-ii endometrial cancer survivors.

primary objectives: i. to determine the feasibility and efficacy of a combined lifestyle intervention (yoga + diet) to positively impact physical function and quality of life for endometrial cancer survivors. outline: patients are randomized to 1 of 2 arms. arm i: participants undergo onsite gentle yoga once weekly over 45-60 minutes for 8 weeks and home-based gentle yoga for 6 weeks. participants also undergo dietary counseling over 8 weeks. arm ii: participants undergo enhanced usual care designed to educate on best practices for exercise, diet and lifestyle change once weekly for 14 weeks.

Eligibility criteria:
inclusion criteria: * english speaking * previous diagnosis of grade 1 or 2, stage i or ii endometrioid endometrial cancers ("type i cancers") as confirmed during surgical intervention for treatment * overweight or obese (\> 25 kg/m\^2) * anytime from treatment * treating oncologist consent * primary physician consent to engage in physical activity unsupervised * ambulatory or able to engage in walking for at least 15 minutes * sedentary lifestyle, as engaging in less than 100 minutes structured aerobic walking, cycling or swimming per week exclusion criteria: * no prior type i endometrial cancer diagnosis * prior diagnosis of other cancer * currently (previous 6 months) engaged in structured exercise either aerobic or yoga based * severe heart or systemic disease: evidence of documented myocardial infarction, chronic unstable angina, symptomatic congestive heart failure, uncontrolled hypertension * severe musculoskeletal disease: severe muscle or joint disorders due to disease or trauma, amputations, or any condition that significantly impair physical capabilities, as defined by the physician * non-ambulatory * concurrent diagnosis of organic brain syndrome, dementia, mental retardation, or significant sensory deficit * major mental illness (e.g., schizophrenia, major depressive disorder) * unwilling to give consent

Keywords: cancer survivors yoga endometrial cancer
ultrasound assessment of isolated distal deep vein thrombosis

Conditions: Iddvt; Pulmonary Embolism (PE)

Summary: retrospective assessment of ultrasound and clinical characteristics of patients with iddvt, development of a pulmonary embolism risk prediction model for thrombus, and provision of appropriate diagnostic and therapeutic recommendations.


Eligibility criteria:
inclusion criteria: diagnosis of new-onset iddvt confirmed by lower limb vascular ultrasound; presence/absence of pulmonary embolism clarified by pulmonary artery cta; ultrasound and pulmonary artery cta results spanning no more than 5 days. exclusion criteria: anticoagulation therapy in the last month; pregnancy or puerperium; recurrent dvt or pe.
hiv, immune activation and salt sensitive hypertension

Conditions: HIV-1-infection; Hypertension,Essential

Summary: high dietary salt is associated with immune activation, elevated levels of inflammatory cytokines and hypertension in murine models. hypertension is independently associated with inflammation in both murine studies and studies in humans. in people living with hiv, these interactions are not well established. the aim of this study is to determine the effect of excess dietary salt on immune cell activation, pro- and anti-inflammatory cytokines and blood pressure between individuals with and without hypertension among people living with hiv and hiv negative persons.


Eligibility criteria:
inclusion criteria: * adults (aged 18 and above) who will be required to verbally consent and sign a consent form * hiv positive or hiv normotensive individuals or hypertensive if hiv, on antiretroviral therapy art treated hypertensive individuals exclusion criteria: * existence of comorbidities such as diabetes mellitus and cancer existing and recent past opportunistic infections, syphilis, hepatitis c and b virus infection and tuberculosis infection; * sick persons (clients seeking healthcare due to an illness rather than routine art clinic reviews) * those with recent and current alcohol consumption and smoking status

Keywords: inflammation human immunodeficiency virus (hiv) salt interleukin 6 interleukin 17a hypertension
physiologic assessment of thrombus aspiration in acute st-segment elevation myocardial infarction patients

Conditions: Myocardial Infarction

Summary: the physiologic assessment of thrombus aspiration in st-segment elevation myocardial infarction (pata-stemi) trial is a single center, prospective, randomized trial with a planned inclusion of 128 patients with the first st-segment elevation myocardial infarction (stemi). patients are, before coronary angiography, randomly assigned to thrombus aspiration using 6 or 7 french eliminate aspiration catheter (terumo medical supply, japan) or to conventional primary percutaneous coronary intervention (pci). the primary endpoint is index of microcirculatory resistance (imr), measured in infarct-related artery, in thrombus aspiration compared to conventional pci group.

background and objective routine thrombus aspiration is superior to conventional primary pci in terms of improved myocardial perfusion in stemi patients. however, myocardial perfusion after thrombus aspiration has not been evaluated by a quantitative, invasive method. investigators intend to determine whether thrombus aspiration of the infarct-related artery increases myocardial perfusion, as measured by imr, compared to conventional primary pci. study design pata-stemi is a single center, prospective, randomized trial with a planned inclusion of 128 patients with the first stemi. patients are randomly assigned, before coronary angiography, to thrombus aspiration using the 6 or 7 french eliminate aspiration catheter (terumo medical supply, japan) or to conventional primary pci. the imr will be determined in infarct-related artery and non-infarct-related arteries without critical stenosis to measure microcirculatory resistance. the primary endpoint is defined as imr in infarct-related artery in thrombus aspiration compared to conventional pci group. secondary end points are myocardial perfusion grade and resolution of st-segment elevation, infarct size and left ventricle remodeling, as assessed by echocardiographic indices. transthoracic echocardiography will be conducted within 24 hours and at 4 months after the primary pci. implications: if manual thrombus aspiration reduces microcirculatory resistance, indicating improved myocardial perfusion, as compared to conventional pci, it might become the preferred strategy in patients with stemi.

Eligibility criteria:
inclusion criteria: * all consecutive patients with stemi * chest pain onset ≤12h, or \>12 h with persistent st-segment elevation * hemodynamically stable patients exclusion criteria: * patients without diagnosis of stemi (pericarditis, for example) * no written informed consent obtained * prior q or non-q mi * prior resuscitation * prior thrombolysis * prior surgical myocardial revascularisation * life expectancy \<6 months * periprocedural death

Keywords: acute myocardial infarction manual thrombus aspiration coronary physiology
the effect of self-acupressure on pain and sleep in coronary artery patients

Conditions: Coronary Artery Disease

Summary: this study will be conducted to evaluate the effect of acupressure applied to patients with coronary artery disease (cad) on pain and sleep quality.

self-acupressur application will improve pain and sleep quality in cad.

Eligibility criteria:
inclusion criteria: * not having a psychiatric diagnosis, * to be able to communicate adequately * not having psychiatric problems * volunteering to participate in research exclusion criteria: * none

Keywords: self-acupressure sleep pain coronary artery patıent
study of inherited changes of receptors located on blood vessels

Conditions: Cardiovascular Disease

Summary: the renin angiotensin system is a complex process involving hormones and enzymes that regulate blood volume and blood pressure. the hormone angiotensin ii is responsible for making blood vessels narrow or constrict. angiotensin ii is found in the blood and can attach to special sites called receptors on blood vessel walls. these receptors are programmed to accept angiotensin ii and cause a constriction of the blood vessel. this function is found in the genetic information of each individual person. occasionally patients have changes in their genes related to angiotensin ii receptors. these changes may result in the receptors acting differently to angiotensin ii, which may affect the function of blood vessels. this study is designed to improve researchers understanding of the physiological effects on blood vessels associated with mutations of the genes responsible for angiotensin ii receptor function.

polymorphisms in the genes encoding for various elements of the renin angiotensin system have been associated with cardiovascular disease. we have isolated novel alleles in the angiotensin ii type i receptor gene. we propose this exploratory investigation to study the physiological effect of these mutations on vascular function in patients and family members who carry these rare alleles.

Eligibility criteria:
patients aged 21 or older with chronic orthostatic intolerance will be included. there will be no exclusion from participation in the study on the basis of ethnicity/race. patients will be recruited in the cardiology branch outpatient clinic, dr. david goldstein (chief neurocardiology section, ninds, nih), or from outside physicians. children will be excluded from the study because of inability in obtaining informed consent. cognitively impaired individuals, prisoners, or other institutionalized persons will not be able to participate.

Keywords: angiotensin ii receptor polymorphism, genetic vascular tone angiotensin ii losartan
non-operative versus operative treatment of acute acromioclavicular joint dislocation

Conditions: Shoulder Dislocation

Summary: the purpose of this study is to compare non-operative treatment versus operative treatment in patients who suffer a complete, acute acromioclavicular (ac) joint dislocation. this study will show if one method is superior to the other and will also show advantages and disadvantages associated with each treatment method.

all patients presenting to the hospital with a type iii, iv or v acute acromioclavicular (ac) joint dislocation and meeting the eligibility criteria will be approached and asked to enter this prospective, randomized clinical trial. after obtaining consent, the subject will be managed in accordance with one of the two randomized treatment strategies. the first treatment strategy will involve conservative (nonoperative) management of the ac joint dislocation. the second treatment strategy will involve operative fixation (i.e. orif) of the dislocation with a hook plate and screws. the subjects in both treatment groups will receive post-operative care according to the same standards and protocol. the surgeon and research staff will be responsible for study follow-up (clinical and radiological assessment) of the patient on admission (baseline), on discharge from the hospital and at post-operative intervals of six weeks, three months, six months, one year and two years. primary and secondary outcomes will be monitored at these post-operative intervals.

Eligibility criteria:
inclusion criteria: * men or women aged 16 to 65 years of age * grade iii (3), iv (4) or v (5) dislocation of the acromioclavicular (ac) joint (evidenced by no contact between the distal clavicle and the acromion as seen in standardized radiographs) * closed injury * ac joint dislocations within 28 days post injury * provision of informed consent exclusion criteria: * grade i(1), ii (2), or vi (6) subluxation/dislocation of the ac joint * open ac joint separation * scapulothoracic dissociation * presence of vascular injury * dislocations over 28 days post-injury * limited life expectancy due to significant medical co-morbidity * medical contraindication to surgery (including pregnancy) * inability to comply with rehabilitation or form completion * inability to provide informed consent * likely problems, in the judgement of the investigators, with maintaining follow-up (i.e., patients with no fixed address, patients not mentally competent to give consent, etc.)

Keywords: acromioclavicular joint shoulder dislocation ac dislocation
study to evaluate implant survival rate of astra tech fixture st in the posterior maxilla with one-stage surgery and early loading

Conditions: Jaw, Edentulous, Partially

Summary: the purpose of this study is primarily to evaluate implant survival rate of astra tech fixture st placed in the posterior maxilla. a one-stage surgical protocol will be used and the implants will be loaded four weeks after implant installation (early loading). marginal bone levels, plaque and status of the periimplant mucosa will also be evaluated. the subjects will be followed for three years.


Eligibility criteria:
inclusion criteria: * age 18 - 75 * unilateral or bilateral edentulism in the posterior maxilla, last tooth should be the canine or the first bicuspid * willing to give informed consent exclusion criteria: * bone height \< 5 mm, in the planned implant area * bone width \< 5 mm, in the planned implant area * previous bone augmentation procedure in the planned implant area * previous failures of endosseous implants * untreated caries and/or periodontal disease of residual dentition * history or presence of any systemic or local disease or condition that would compromise post-operative healing and/or osseointegration * systemic corticosteroids or any other medication that would compromise post-operative healing and/or osseointegration * current alcohol or drug abuse * unable or unwilling to return for follow-up visits for 3 years
medical-biological research of the pathogenesis of covid-19 disease caused by sars-cov-2

Conditions: Covid19

Summary: сonducting in-depth medical and biological studies of the pathogenesis of the disease caused by the sars-cov-2 in moscow, the moscow region and some other regions of the russian federation.

to date, none of the methods used to test for coronavirus infection provide reliable information about the status of an individual's infection. common tests based on pcr, carried out on the basis of samples taken from the human respiratory tract, give a positive answer in far from all cases. antibody tests may not record the initial stages of the disease, or may not reveal residual immunity in those who have been ill, while giving cross-reactions to other common coronaviruses. a comprehensive assessment of the biological parameters of the virus and the parameters of the immune response to infection is required. in this regard, we propose an integrated approach, including the use of pcr testing technology, analysis of the immune response in the form of antibodies of all major classes (igg, iga), determination of inflammation markers, c-reactive protein, detailed blood test, ferritin and troponin. in addition, an analysis of the genetic diversity of strains of the pathogen covid-19 circulating among various groups of the population of the russian federation will be carried out. to collect and analyze data, it is planned to enter information into a special electronic system and analyze the collected data with a wide range of informative methods that allow "layer by layer" to compare and collect a complete picture of what is happening. objectives of the study: 1. identifying the percentage of infected in the population in moscow, the moscow region and some other regions where the epidemic situation in connection with sars-cov-2 remains tense; 2. study of genetic diversity (including metavirome) and dynamics of structural variability of the causative agent of coronavirus infection in the studied regions; 3. studying the features of the formation and tension of immunity in patients who have undergone coronavirus infection of varying severity; 4. clarification of the mechanisms of occurrence and development of coronavirus infection. in the study of biological samples obtained from research participants, methods of proteomics, peptidomics, next generation sequencing (ngs), physicochemical methods of analysis will be used.

Eligibility criteria:
inclusion criteria: * age over 18 and under 75 years old * covid-19 diagnosis confirmed by pcr test * written consent to participate in the study exclusion criteria: * unwillingness or inability to give written informed consent to participate in the study * a serious condition with a threat to life or contraindications that prevent the collection of biomaterial * oncological diseases outside the stage of remission

Keywords: metavirome sars-cov-2 pathogenesis oxidative stress peptides
mild water-filtered near infrared whole-body-hyperthermia as an adjunct in the treatment of fibromyalgia

Conditions: Fibromyalgia

Summary: the purpose of the study is to evaluate whether mild walter-filtered near infrared hyperthermia produces an additional benefit when applied as an adjunct to standard multimodal rehabilitation compared to standard multimodal rehabilitation only in patients with fibromyalgia.

mild systemic heat agents, including infrared whole-body hyperthermia, are used as treatment options in multimodal rehabilitation programs for fibromyalgia in germany. however, no randomized controlled clinical trial exists on their effectiveness for this condition. this study is designed as an add-on study to evaluate the additional benefit of mild walter-filtered near infrared hyperthermia and a standard multimodal rehabilitation program compared to a standard multimodal rehabilitation program only. standard multimodal rehabilitation is configured as usually applied in clinical trials with exercise, cognitive behavioral therapy, and health education as the main treatment components. mild walter-filtered near infrared hyperthermia (heating-up to 38.1 degrees c body core temperature followed by a 15-min heat retention period) is administered twice a week over 3 weeks during a rehabilitation hospital stay. primary outcome measures are measured at baseline, postintervention, 3 and 6 months postintervention. analysis is done by intention to treat, for significance testing repeated measures ancova is used.

Eligibility criteria:
inclusion criteria: * participants must meet the american college of rheumatology 1990 criteria for fibromyalgia * participants must report a score ≥ 4 on the pain intensity subscale of the fibromyalgia impact questionnaire (range: 0-10) * participants must report a score ≥ 4 on the normalized physical functioning subscale of the fibromyalgia impact questionnaire (range: 0-10) * participants must be aged between 18 and 70 years exclusion criteria: * severe cardiovascular disease * metabolic disease * nervous system disorder * blood coagulation disease * cancer * acute inflammatory disease * status after organ transplantation * reduced general health (karnofsky index ≤ 50) * pregnant women * breast feeding women * persons involved in a pending litigation for early pensioning due to fibromyalgia * persons planning to apply for a pension due to fibromyalgia

Keywords: fibromyalgia rehabilitation physical medicine whole-body hyperthermia water-filtered near infrared