cognitive - cognitive function after sevoflurane or propofol anesthesia for open-heart operations

Conditions: Other Functional Disturbances Following Cardiac Surgery; Memory Disorders

Summary: the aim of the study is to prove whether general anesthesia with inhaled sevoflurane reduces the frequency of neurological and cognitive impairment after open-heart operations with use of cardiopulmonary by-pass (cpb) in comparison with intravenous anesthesia with propofol.

patients assigned to the "sevoflurane" group will be anesthetized with inhaled sevoflurane (induction and conduction of general anesthesia) and empirically administered fentanyl und pancuronium. during the cpb, sevoflurane will be delivered via the oxygenator of the cpb-machine. patients assigned to the "propofol" group will be anesthetized with continuous propofol infusion and empirically administered fentanyl and pancuronium. the level of anesthesia will be monitored with bis (bi-spectral index) - desirable level of 40 - 60. following preoperative data will be recorded: age, years of school education, nyha-class, lvef by tte, comorbidities, glucosylated hemoglobin in patients with diabetes, non-invasive arterial blood pressure the day before the operation, smoked cigarettes, alcohol abuse. recorded data from operation: type of surgery, cbp duration, aortic clamp duration, duration of arterial hypotension (map \< 60 mmhg) on cpb or sap \< 90 after cpb, the lowest perfusion gradient (map-cvp), the lowest po2 in arterial blood and lowest blood oxygen saturation, lowest and average brain blood saturation (measured by invos), steroid dosis, aprotinin dosis, mannitol dosis on cpb, epiaortic echocardiography for aortic clamping, tee before weaning from cpb with evaluation of deaeration of the left ventricle, highest serum glucose level, highest oesophageal temperature. data collected after operation: time to tracheal extubation, doses of catecholamines, consciousness disorders, crp, s-100b protein, glucose level, core temperature, icu stay, stay at the surgery department, hospital stay. the patients will undergo a psychological examination four times: before the operation, before discharge from hospital (usually 4-6 days after the operation), 3 and 12 months after the operation. the psychological test for evaluating the cognitive modalities will include: 1. verbal learning - the rey's avlt test 2. direct verbal memory - number repeating attempt from the wais-r/pl test 3. direct nonverbal memory - memory test of geometric figures by benton 4. operating memory test - tmt test 5. the cognitive interference test - a modified stroop test 6. verbal fluence - according to the boston test of aphasia 7. concentration and work effectiveness - by the number symbol test by wechsler. 8. mood - beck's depression scale 9. neecham delirium scale - during the first 24-36 hours after surgery 10. the gough's adjective test will be performed with in-house relatives of the patient for evaluation the eventual emotional and eventual personality changes neurological examination will be performed before and 6 days after surgery.

Eligibility criteria:
inclusion criteria: * adults * valve-repair open-heart surgery without coronary artery bypass grafting exclusion criteria: * active infective endocarditis * previous cardiac surgery * emergency operations * chronic renal failure (serum creatinine \> 2,0 mg/dl) * left ventricle ejection fraction \< 30% * myocardial infarction within last 30 days

Keywords: sevoflurane, propofol, heart surgery, cardiopulmonary bypass, memory disorders,