Kornimate/medical-research-clean huggingface dataset:
evaluation of potential causes of nap modulated tinnitus

Conditions: Tinnitus; Hearing Disorders; Ear Diseases; Otorhinolaryngologic Diseases

Summary: the proposed research is a non-interventional study made to evaluate different measurements on 1 group of participants, before and after taking a nap, aiming to potentially guide future investigations on nap-modulated tinnitus to better understand this phenomenon. the main hypothesis is that sleep apneas could be correlated with an increase of tinnitus intensity.

1. - background : tinnitus is a really important concern due to its high prevalence (10% world population) and its deteriorating effects on life quality. subjective tinnitus still remains a scientific enigma because of its partial elucidation. the limited knowledge on its causes can be partially attributed to its intrinsic heterogeneity. in questionnaires previous to this study, 34% of participants showed a characteristic symptomatology of interactions between tinnitus and their sleep : they feel their tinnitus at its maximum intensity after sleeping periods (nap and sleep). in most cases they describe a frank rise of the intensity, compared in scientific papers to the "exploding head syndrome". therefore this study aims to determine what are the main physiopathological processes correlated to the rises of tinnitus 2. - objectives : estimate the correlations between tinnitus intensity changes (before and after the nap) and the number of sleep apneas. secondary measurements are described in the outcome field.

Eligibility criteria:
inclusion criteria: * affiliated participant or beneficiary of a social security scheme * acceptation of protocol and signature of non-opposition * frankly nap-modulated tinnitus (increase of intensity after napping) * tinnitus maskable by white noise equal or inferior to 85 db exclusion criteria: * persons under juridic protection (guardianship or safeguard of justice) * clear cognitive incapacity (not understanding/nor apprehend the study tasks) * pregnancy or breast feeding * epilepsia * non-equilibrated chronic metabolic pathology * non-equilibrated psychiatric pathology * difficulty in napping * important hyperacusis * meniere's disease, fast fluctuating tinnitus (seconds or minutes), pulsatile tinnitus * any patient benefiting of a tinnitus treatment that was modified in the last 3 months * superficial wound, open or partially not cauterized

Keywords: nap modulated tinnitus sleep modulated tinnitus sleep apneas
assessing chronic pain conditions in patients (pts) with and without (w&wo) interstitial cystitis

Conditions: Interstitial Cystitis

Summary: interstitial cystitis (ic) is a chronic disorder with significant symptoms of urinary urgency, frequency and pelvic pain. ic is more prevalent in women than men. similar to other chronic pain syndromes such such as irritable bowel syndrome (ibs) and fibromyalgia, the cause of ic is not fully understood. two subtypes of ic have been identified: classic ic (ulcerative ic) where visible ulcers exist in the bladder and non ulcerative ic, where bladder abnormalities are not apparent but significant bladder-related symptoms exist. we hypothesize that ulcerative ic is a disease of the bladder whereas non ulcerative ic is a more generalized and centrally-mediated chronic pain syndrome similar to ibs and fibromyalgia. to test this hypothesis, we will compare the presence of pain conditions/symptoms in ulcerative vs. non ulcerative ic women vs. community dwelling women (controls) without an ic diagnosis.


Eligibility criteria:
inclusion criteria: * women over 18 years of age with ic identified by investigator (cases); * women over 18 years of age with ic (controls) exclusion criteria: * male gender; * subjects less than 18 years of age
research of the effect of reservoir oxygen mask application on respiratory parameters in sedated adult patients for gastrointestinal system endoscopy

Conditions: Oxygen Deficiency

Summary: with the oxygen mask with reservoir, oxygen can be given to patients with fio2 values that can reach 80-100%. reservoir oxygen mask is superior to other oxygen treatment methods with the high oxygen rate applied.our hypothesis is that the use of an oxygen mask with a reservoir will reduce the incidence of respiratory complications in adult patients who will undergo sedation in the endoscopy unit.

during the sedation procedure in the endoscopy unit, patients who used a reservoir oxygen mask will be examined. patients over the age of 18 and under the age of 70, with asa 1-2 risk score, who are planned to be operated under sedation in the endoscopy unit of our hospital will be included. patients who do not have verbal and written consent to participate in the study, have an asa3-4 risk score, and are scheduled for emergency procedures will be excluded from the study. no premedication will be applied to patients admitted to the endoscopy unit. as a standard, intravenous vascular access will be established with a 22 gauge intraket on the back of the left hand in all patients, 6-10 lt/minute oxygen therapy will be started with a reservoir mask, and peripheral oxygen saturation, end-tidal co2, blood pressure arterial values will be monitored and recorded. these parameters will be monitored and recorded every five minutes during the procedure. in addition, the sedative agents applied to the patients and their doses will be recorded. after the procedure, all patients will be taken to the recovery room, where they will be observed until the modified aldrete score is 9 or higher. the recovery times of the patients, nausea, vomiting and similar symptoms will be followed and recorded.

Eligibility criteria:
inclusion criteria: * patients over the age of 18 and under the age of 70 * patienst with have an asa1-2 risk score exclusion criteria: * patients who do not have verbal and written consent to participate in the study * patienst with have an asa3-4 risk score, * patients scheduled for emergency intervention.
comparison of sodium fluoride positron emission tomography and magnetic resonance imaging of spine and sacroiliac joints for detection of inflammatory lesions in spondyloarthritis patients

Conditions: Spondyloarthritis

Summary: the purpose is to compare detection of axial inflammatory lesions in patients affected by spondyloarthritis (spa) with sodium fluoride positron emission tomography (pet) and magnetic resonance imaging (mri), the reference technique. it would be interesting to show the superiority of sodium fluoride pet on mri for diagnosis of inflammatory lesions. it could be used for diagnostic care but also therapeutic care of patients with early forms of spondyloarthritis. secondary purposes are: * to evaluate performances of sodium fluoride pet in detection of spa peripheral damage (except spine and sacroiliac joints) * to evaluate bone inflammation (axial and peripheral) with sodium fluoride pet and compare these data to clinic-biologic parameters used in clinical practice (basdai, basfi, basmi, sedimentation rate, c-reactive protein (crp)) and to structural evaluation (sacroiliac new york, msasss and basri scoring methods) * to study correlation of axial and peripheral bone inflammation (spine and sacroiliac joints) evaluated with sodium fluoride pet with biologic markers of inflammation and bone remodeling (mmp-3; dkk-1, il-6, il-17, tnf-α). known biologic markers of inflammation in spa are correlated to activity obtained with mri. it is interesting to compare to activity obtained with pet. moreover, it has been recently showed the disassociation of inflammation and structural progression (anti-tnf treatments do not prevent structural progression) that is associated to markers of bone remodeling whose activity is influenced by an activation/inhibition system of biologic markers of inflammation.


Eligibility criteria:
inclusion criteria: * 18-50 year-old patients affected by axial or mixed spa (asas criteria) or \>18 year-old patients according to new york criteria * patients with bone marrow edema lesions in sacroiliac joints and/or spine detected with mri * no therapeutic changes between hospitalization for evaluation of spa activity and inclusion visit * informed consent * affiliation to social security plan exclusion criteria: * refusal or impossibility of signed informed consent * doubt about possible pregnancy in women of childbearing potential * pregnancy and breastfeeding * history of drug addiction, alcoholism, psychological problems, severe co-morbidities * renal insufficiency (creatinine clearance \< 60 ml/min) * juridical protection

Keywords: magnetic resonance imaging sodium fluoride positron emission tomography
outcome of using transfixing k wire ln ddh with hypoplastic head and severe generalised ligamentous laxity

Conditions: Developmental Dysplasia of the Hip

Summary: this study is to evaluate the outcome of using transfixing hip k wire in developmental dysplastic hip in patients with hypoplastic head and severe generalised ligamentous laxity.

the goal of treatment in developmental dysplasia of the hip (ddh) is to obtain and maintain a stable concentric reduction. surgical treatment is done by open reduction through a medial approach or anterolateral approach with pelvic osteotomy,capsulorhaphy, femoral shortening and derotational osteotomy. transfixing the femoral head with kirschner wire during open reduction has long been thought to provide stability to the hip without damaging the femoral head or the acetabulum and to decrease the risk or re-dislocation. the aim of this study is to assess the effect of transfixing the hip with kirschner wire during the operative treatment of hip dysplasia in children after the walking age on the final radiological and clinical results and to compare the risks with the benefits of adding this step.

Eligibility criteria:
inclusion criteria: 1. patients older than 1 year and younger than 7 2. patients with hypoplastic head 3. patients with severe ligamentous laxity (beighton score ≥ 4) exclusion criteria: 1. patients younger than 1 year and older than 7 years old. 2. beighton score \< 4 3. secondary hip dislocation (neuromuscular disorder) as cerebral palsy , myelodysplasia or arthrogryposis.

Keywords: developmental dysplasia of the study kirschner wire hypoplastic head ligamentous laxity
deep anterior lamellar keratoplasty (dalk)

Conditions: Keratoconus

Summary: the purpose of this study is to report outcomes of deep anterior lamellar keratoplasty (dalk) using the big-bubble technique.

purpose: to report outcomes of deep anterior lamellar keratoplasty (dalk) using the big-bubble technique. methods: thirty four unselected consecutive patients were submitted to dalk big-bubble technique. intraoperative and postoperative complications, postoperative uncorrected visual acuity (ucva), best spectacle-corrected visual acuity (bscva), spherical equivalent (se), corneal topography, and endothelial cell density were evaluated. all patients were followed for at least 6 months.

Eligibility criteria:
inclusion criteria: * keratoconus exclusion criteria: * central endothelial cell count less than 2000 cells/mm2 * glaucoma or intraocular pressure greater than 21 mmhg * amblyopia * retinal abnormalities * diabetes mellitus * steroid or immunosuppressive treatment * connective tissue diseases

Keywords: lamellar keratoplasty keratoconus penetrated keratoplasty visual acuity
interleukin 20 and periodontal tisuue destruction

Conditions: Periodontitis

Summary: periodontitis is an inflammatory disease that causes destruction of periodontal tissues. il-20, on the other hand, is known as a potent angiogenic, chemotactic, and pro-inflammatory cytokine associated with various chronic inflammatory disorders. il-20 has a significant role in the regulation of osteoclastogenesis and osteoblastogenesis. the aim of this study was to evaluate the effect of il-20 on periodontal destruction. in the study, a total of 60 participants were included, 30 of whom were systemically and periodontally healthy (control group) and 30 of whom were systemically healthy and had periodontitis (periodontitis group). gcf and serum samples were collected from the participants for biochemical analysis. elisa method was used to determine il-20, tnf-α, il1β/il-10, rankl/opg and mmp8 levels


Eligibility criteria:
inclusion criteria: * the following criteria were required for inclusion: being systemically healthy, not smoking, not using antibiotics or systemic corticosteroids within the previous three months, not being pregnant or nursing, not having a chronic inflammatory disease, not receiving periodontal therapy within the previous six months, and possessing at least 20 teeth exclusion criteria: * smoking, using antibiotics or systemic corticosteroids within the previous three months, pregnant, receiving periodontal therapy within the previous six months
a study of glaucoma therapy to treat open-angle glaucoma or ocular hypertension

Conditions: Open-Angle Glaucoma; Ocular Hypertension

Summary: the purpose of the study is to evaluate the safety and effectiveness of an investigational glaucoma therapy in patients with open-angle glaucoma or ocular hypertension.


Eligibility criteria:
inclusion criteria: * 18 years or older. * diagnosis of open-angle glaucoma (with or without pseudoexfoliation or pigment dispersion component) or ocular hypertension. * mean intraocular pressure (iop) in at least one eye greater than 21 mmhg and less than or equal to 36 mmhg at screening visit. * other protocol-defined inclusion criteria may apply. exclusion criteria: * pregnant * history of chronic or recurrent severe inflammatory eye disease. * history of ocular infection or ocular inflammation within the past three months in either eye. * other protocol-defined exclusion criteria may apply.

Keywords: open-angle glaucoma ocular hypertension
hohenheim malnutrition study in geriatric fracture patients

Conditions: Geriatric Patients

Summary: the aim of this study is to evaluate long-term effects of early and prolonged individualized and optimized nutritional support using ons for four weeks, in combination with a defined physiotherapy regimen, on sarcopenia and other outcome parameters in elderly fracture patients.


Eligibility criteria:
inclusion criteria: * age ≥ 75 years, or * age ≥ 65 years and carlson-comorbidity-index of ≥ 5 and * written informed consent exclusion criteria: * progressive cancer disease * relevant pre-existing chronic conditions (in order to avoid disease related impact on outcome parameters) * insufficient german speech intelligibility

Keywords: oral nutritional supplementation geriatrics bone fracture
daily self-weighing and holiday-associated weight gain in adults

Conditions: Obesity

Summary: background: previous studies report 0.4-1.5kg of weight gain during the holiday season, which may contribute to annual weight gain. purpose: to test whether daily self-weighing (dsw) can prevent holiday weight gain. hypothesis: we hypothesized that daily self-weighing would effectively prevent weight and fat gain, and that individuals with overweight and obesity would respond most favorably to dsw.

a single-blinded randomized control trial: adults (age 18-75y, bmi ≥ 18.5kg/m2) were randomized to either a control or daily self-weighing (dsw) group. there were 3 testing visits: pre-holiday (v1: within 7d before thanksgiving), post-holiday (v2: within 7d after new year's day), and a follow-up (v3: 14 weeks after v2). the dsw group were given wi-fi scales that provide graphical feedback of daily weight. they were instructed to perform dsw during the holidays and to try not to gain weight above baseline weights. anthropometrics were measured at each visit.

Eligibility criteria:
inclusion criteria: * bmi of at least 18.5 kg/m2 * recognizing or celebrating at least two holidays between november and january * access to wifi exclusion criteria: * current eating disorder, history of an eating disorder * involvement in a current weight loss and/or exercise program * pregnancy or nursing * any medications or chronic diseases affecting metabolism or body weight

Keywords: holiday weight gain daily self-weighing weight maintenance caloric titration method obesity overweight holiday season
identification of genetic causes of calcific aortic valve disease

Conditions: Calcific Aortic Stenosis; Calcific Aortic Stenosis - Bicuspid Valve; Aortic Valve Disease; Aortic Valve Calcification; Aortic Diseases; Aortic Aneurysm; Aortic Valve Cusp Abnormality; Aortic Valve Disease Mixed; Aortic Valve Insufficiency

Summary: this study aims to identify the molecular genetic causes of the variability in development of calcific aortic valve disease in bicuspid and tricuspid aortic valves and their associated aortic dilation.


Eligibility criteria:
inclusion criteria: * patients with a plan to undergo elective aortic valve replacement and/or ascending aortic surgery exclusion criteria: * age \< 20 years * unable/unwilling to consent * history of aortic valve replacement or transcatheter aortic valve replacement (tavr) * history of endocarditis * history of rheumatic fever * history of chest radiotherapy * history of organ transplant
effect of metoclopramide versus sumatriptan for emergency department treatment of migraine headache

Conditions: Migraine Disorders

Summary: the purpose of this study is to determine which drug makes lower migraine headache

there are different options to manage benign headache in emergency department.the investigators compared intravenous metoclopramide with subcutaneous sumatriptan to relieve pain in emergency department.

Eligibility criteria:
inclusion criteria: * 20-60 years old and presented with acute headache similar to previous episodes, * with or without phonophobia, * photophobia, * vomiting or nausea. exclusion criteria: * fever or neck stiffness, * altered mental state, * pregnancy, * recent trauma or seizure (within 24 hours), * focal neurological abnormality on physical examination, * allergy to metoclopramide, * hypertension, * cardiovascular diseases. also if the patients had taken a triptan or ergot during the last 24 hours were excluded from the study.

Keywords: metoclopramide sumatriptan migraine headache
clinical and basic investigations into congenital disorders of glycosylation

Conditions: Congenital Disorders of Glycosylation

Summary: the purpose of this research is to study the natural history of congenital disorders of glycosylation and its causes and treatments.

the investigators are conducting a natural history study of patients with congenital disorders of glycosylation (cdg). the study will look into the progression of the disease amongst the participants and also look at the clinical symptoms and how they vary amongst different diseased population groups. the participants will be asked to fill out questionnaires either on their own or with a provider that will grade the severity of disease and document symptoms and diet. participants will have an opportunity to submit blood, urine, and stool samples that will be tested for biomarkers for cdg. participants will also complete dietary food records, physical exams, cdg scores, and the promis questionnaires to assess disease progression and severity.

Eligibility criteria:
inclusion criteria: * individuals with a genetically, enzymatically, or molecularly confirmed diagnosis of cdg or ngly1 deficiency exclusion criteria: * none

Keywords: cdg cddg congenital disorders of glycosylation congenital disorders of deglycosylation alg1 alg3 alg6 alg12 alg13 cog6 dpagt1 dpm1 edem3 man1b1 mpdu1 mpi ngly1 pgap3 pgm1 piga pigg pign pigs pigt pmm2 slc35a2 slc35c1 slc39a8 srd5a3 ssr4 fut8 galnt2 man2b2 vma21
prevalence and risk factor of np in women with luts

Conditions: Lower Urinary Tract Symptoms

Summary: the knowledge of prevalence and risk factors of nocturnal polyuria might be important for the treatment of women with lower urinary tract symptoms (luts). thus, our aim is to describe the prevalence and risk factors of nocturnal polyuria in women with luts.

between september 2010 and january 2019, all women with luts visiting urogynecological department of a medical center for urodynamic evaluation were reviewed. nocturnal polyuria was defined when the proportion of night-time voided volume over 24-hour voided volume was greater than 33% for ≥65 year-old women, and when the proportion of night-time voided volume over 24-hour voided volume was greater than 20% for \<65 year-old women. backward stepwise multivariable logistic regression analysis was performed using all statistical variables in the univariate logistic regression analysis. p \< 0.05 was considered as statistical significant.

Eligibility criteria:
inclusion criteria: * women with lower urinary tract symptoms * complete a 3-day bladder diary exclusion criteria: * \ 85 y/o * regular urethral catheterization or intermittent self-catheterization * urinary tract infection or chronic inflammation in the previous 2 weeks * bladder calculus * neurogenic bladder due to radical hysterectomy or injury of the central nervous system * history of pelvic radiotherapy or a preexisting malignant pelvic tumor.

Keywords: nocturnal polyuria bladder diary
endocardial mapping of left atrium for evaluation of concomitant surgical ablation lesions

Conditions: Atrial Fibrillation

Summary: concomitant ablation is an effective treatment for patients with various types of atrial fibrillation undergoing heart surgery. however, recurrences of tachycardias after concomitant ablation can happen and seem to be mostly related to reentry mechanism resulting in atrial tachycardias. the aim of the study is to perform invasive re-mapping of ablated regions in the atria to assess durability of ablation lesions and prevalence of conduction gaps that can be targets for additional ablation to lower longterm arrhythmia recurrence.

patients after concomitant ablation for treatment of atrial fibrillation will be enrolled. at ablation procedure pulmonary veins will be isolated and additional ablation lines will be performed in the left atrium (posterior wall box lesion, connecting lesion to the mitral annulus, connecting lesion to the left atrial appendage,...) and the right atrium (intercaval connecting lesion, cavotricuspid isthmus lesion,...) and left atrial appendage will be excluded (suture and excision, clipping device,...) at the discretion and expertise of the operator. radiofrequency and/or cryoablation will be used at the discretion and expertise of the operator. invasive mapping with a high density mapping catheter connected to a three-dimensional electro-anatomical mapping system will be performed to assess pulmonary vein isolation and linear lesion durability 3 months after the initial concomitant ablation. potential gaps will be identified and ablated with a radiofrequency ablation catheter. participants will be followed-up clinically and with holter ecg before and after the invasive re-mapping procedure up to the first year after the concomitant ablation procedure.

Eligibility criteria:
inclusion criteria: * all patients scheduled for any kind of elective heart surgery having also indication (ehra and/or hrs guidelines) to undergo concomitant ablation for any type of atrial fibrillation exclusion criteria: * life expectancy of less than one year, * severe heart failure with left ventricular ejection fraction below 35%, * emergency surgery due to a life threatening condition such as acute aortic dissection, papillary muscle rupture, acute endocarditis, major trauma,...

Keywords: concomitant ablation heart surgery remapping