Kornimate/medical-research-clean huggingface dataset:
effect of meloxicam versus placebo in mainland chinese patients with osteoarthritis of the knee

Conditions: Osteoarthritis of the Knee

Summary: this study is to validate the western ontario and mcmaster universities osteoarthritis index (womac) tool in mainland chinese patients with osteoarthritis of the knee . this study will also evaluate the effects of mobic versus placebo on reducing the symptoms of osteoarthritis in this population.

to validate culturally the womac tool in mainland china and observe the different response of meloxicam and placebo in a patient population with osteoarthritis of the knee

Eligibility criteria:
inclusion criteria: subjects are required to meet the following criteria to be eligible for randomization into this study: * male or female chinese subjects, 18-75 years of age; * subjects must have a diagnosis of oa of the index knee based on american college of rheumatology criteria with x ray confirmation (a kellgren lawrence x ray grade of greater than or equal to 2) (kellgren j. \& lawrence j, 1957) * subjects must have have an nrs and a womac pain sub scale score of 4 at screening and at baseline based on four daily diary entries exclusion criteria: subjects presenting with any of the following will not be included in the study: * history of other disease that may involve the index (painful) knee including inflammatory joint diseases or have had recent surgical intervention on the knee. * diagnosed as having or has been treated for esophageal, gastric, pyloric channel, or duodenal ulceration within 30 days prior to receiving the first dose of study medication. history of or active gastrointestinal disease (eg, inflammatory bowel disease), a chronic or acute renal or hepatic disorder, or a significant coagulation defect. * signs and symptoms of clinically significant cardiac disease

Keywords: validation of the womac in chinese subjects with osteoarthritis of the knee
a brief intervention to improve medication knowledge and adherence among family medicine patients in south texas

Conditions: Diabetes Mellitus, Type 2; Hyperlipidemia; Hypertension

Summary: this study examines a brief physician counseling intervention to improved medication knowledge and compliance in family medicine patients who have diabetes, hypertension or high cholesterol.

this study examined a brief intervention to improve medication knowledge and compliance in family medicine patients. the study was conducted in a network of six family medicine residency programs in south texas, funded by a grant from the health research services administration. family medicine patients were invited to participate in the study if they took medicines for type 2 diabetes, hypertension, or hyperlipidemia and responded "yes" to the screening question: "do you sometimes have trouble taking all your medications as prescribed?" at enrollment, clinic staff administered a medication survey to patients to assess the variables: readiness to change, reported medication knowledge; reported compliance, and predictors of knowledge and compliance. self-reports of compliance were validated with a social desirability scale, and with physician impressions. six and twelve weeks post-enrollment, interviewers administered followup surveys by telephone to assess change over time in medication knowledge and compliance. one year post-enrollment, investigators conducted a chart review to examine changes in health outcomes: blood pressure or hba1c or cholesterol levels, and number of hospitalizations. three physicians per clinic site (18 total) conducted medication interventions for the purpose of this study. this intervention was brief behavior change counseling done in the context of a routine office visit, guided by simple strategies outlined in rollnick et al (1999). first, physicians reviewed subjects= medication regimen and addressed their concerns. we selected a simple strategy from rollnick et al. - a brainstorming session - that built patients' confidence to change health behaviors. afterward, physicians offered pillboxes to patients who desired them, and reviewed potential adverse reactions to medicines. one week after the intervention, physicians telephoned patients to reinforce behavior change and to answer questions about the medications. prior to training physicians to conduct this intervention, we enrolled five subjects per physician into a control group. we attempted to blind physicians to these patients= enrollment status; usual care was provided to control subjects. after training, enrollees' charts were flagged so that physicians knew to conduct the intervention. we sought five patients per physician to receive the intervention.

Eligibility criteria:
inclusion criteria: * sometimes has trouble taking medicines as they're prescribed * has diabetes type 2, or hypertension, or high cholesterol for which they take prescription medicines * is a patient of 18 doctors conducting the intervention exclusion criteria: * subjects under age 18

Keywords: patient compliance hispanics health behavior family physicians primary healthcare
an efficacy study of bcs clearing the oral colonized bacterium in hospitalized patients with copd

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the purpose of study is to evaluate the efficacy and safety of benzalkonium chloride solution clearing the oral colonized bacterium in hospitalized patients with copd.

this a randomized, double-blind, parallel, single-center, exploratory trial. 60 patients will be randomized to two treatments: benzalkonium chloride solution treatment or normal saline treatment.the purpose of study is to evaluate the efficacy and safety of benzalkonium chloride solution clearing the oral colonized bacterium in hospitalized patients with copd.

Eligibility criteria:
inclusion criteria: 1. copd patients in hospitalized. 2. aged from18 to 70 years (including 18 and 70). 3. patients participating in this trial should sign icfs. 4. patients with good understanding, could conduct this study with investigators. exclusion criteria: 1. history of mouthwash allergies, allergic rhinitis or dermatitis. 2. patients with oral ulcers, severe periodontal disease, oral mucosal lesions or oral cancer, patients received special oral clean. 3. patients with removable denture. 4. patients with malignant blood diseases. 5. history of using cytotoxic drugs or biological immunosuppressants ( such as tnf-α inhibitors ). 6. had used clinical study drugs before 28 days enrollment. 7. had used clinical study drugs before 28 days enrollment.
door-to-door survey of cardiovascular health, stroke and ischemic heart disease in atahualpa

Conditions: Stroke; Ischemic Heart Disease

Summary: the aim of the atahualpa project is to evaluate the cardiovascular (cvh) status of the inhabitants of a rural village of coastal ecuador as well as to determine the prevalence and retrospective incidence of stroke and ischemic heart disease. the protocol may be used as a pilot for large-scale studies attempting to evaluate the cvh of rural or even urban centers of latin america, to implement cost-effective strategies directed to reduce the burden of stroke and cardiovascular diseases in the population at large.

this is a 3-phase epidemiological study. during phase i, two general physicians and a nurse will perform a door-to-door survey of all atahualpa residents aged ≥ 40 years. these persons will be eligible for being screened with standardized questionnaires to identify those with suspected stroke or ischemic heart disease, and to evaluate their cardiovascular health (cvh). persons will be directly interviewed unless aphasic or mentally impaired; in such cases, relatives or caregivers will answer the questions. we plan to use the epidemiologic method of capture-recapture to enhance the detection of all possible cases of stroke and ischemic heart disease \[13\]. so, besides the door-to-door survey, we will review the medical records from the only one health center of atahualpa, as well as the original files of our survey performed in 2003 at the same village \[12\]. in phase ii, certified neurologists and cardiologists will move to atahualpa to examine all individuals who screened as suspected cases of stroke or ischemic heart disease. in addition, a random sample of 2% of individuals who were considered negative during the screening phase (matched by age and gender to suspected cases) will also undergo a complete neurologic and cardiologic examination to assess possible false negative cases during the survey. in phase iii, all patients with a clinical diagnosis of stroke and ischemic heart disease will be invited to undergo further examination in guayaquil.

Eligibility criteria:
inclusion criteria: * atahualpa residents aged ≥ 40 years exclusion criteria: * patients who do not sign the informed consent form

Keywords: stroke myocardial infarction cardiovascular health population study
mapping the health status of the population of french polynesia: the mataea project

Conditions: Non Communicable Diseases; Microbiome; Communicable Diseases; Pesticide Exposure; Metal Poison; Genetics Population; Ciguatera

Summary: this is a cross-sectional study carried out on a sample of the adult population aged 18 to 69, distributed over the five archipelagos of french polynesia. participation in the study involves: agreement to answer a questionnaire to collect information on socio-demographic characteristics, lifestyle habits and medical history; physical measurements (height, weight, waist circumference, blood pressure and skin pigmentation); and agreement to take biological samples (blood, saliva and stool) for biological, genetic and microbiological analyses. the aim of the study is to assess the current health status of the population of french polynesia and to evaluate the influence of contextual risk factors (lifestyle, place of residence, history of infection) and intrinsic susceptibility factors (genetics, age, gender, microbiota) in relation to non-communicable and infectious diseases.


Eligibility criteria:
inclusion criteria: * be aged 18 or over and under 70 on the date of recruitment * having signed the consent form exclusion criteria: * minors * pregnant or parturient women, and nursing mothers * persons deprived of their liberty by a judicial or administrative decision * adults who are the subject of a legal protection measure or who are unable to express their consent * people undergoing psychiatric care * individuals who are not affiliated to a social security scheme or beneficiaries of such a scheme * homeless people * disabled people (unable to move) * people unable to answer the questionnaire

Keywords: cross-sectional survey non-communicable disease communicable disease french polynesia population genetics
determination of spo2 and pr accuracy specifications at rest (71ag_vital-0031)

Conditions: Hypoxia

Summary: the aim of this study is to determine the accuracy of devices called pulse oximeters, which measure blood oxygen by shining light through fingers, ears or other skin, without requiring blood sampling. study will be used with patients at rest

this study is intended to evaluate performance of a new design pulse oximeter (test device) manufactured by nihon kohden corporation sufficiently to support performance claims for an fda 510k submission or iso technical file. specifically, spo2 and pulse rate accuracy will be assessed for a nihon kohden olv-4202 pulse oximeter with adult patients under a controlled setting of varying levels of inhaled oxygen concentration levels for patients at rest.

Eligibility criteria:
inclusion criteria: * both male and female subjects who can give written informed consent * healthy subjects capable of undergoing controlled hypoxemia to the levels outlined in the desaturation profile * meeting the demographic requirements exclusion criteria: * pregnant women * significant arrhythmia * blood pressure above 150 systolic or 90 diastolic * carboxyhemoglobin levels over 3% * subjects whom the investigator consider ineligible for the study
study evaluating the safety and efficacy of erb-041 on reduction of symptoms associated with endometriosis in reproductive-aged women

Conditions: Dysmenorrhea; Dyspareunia; Endometriosis; Pelvic Pain

Summary: the purpose of the study is to evaluate the efficacy and safety of two doses of erb-041 (75 mg and 150 mg) relative to placebo on the relief of endometriosis-related symptoms (dysmenorrhea, pelvic pain, and deep dyspareunia) in reproductive aged women.


Eligibility criteria:
inclusion criteria: * surgical diagnosis of endometriosis within the last 10 years * sexually active, nonpregnant, nonlactating women (18-45 years) with regular menstrual cycles who are willing to use non-hormonal contraception exclusion criteria: * conditions requiring the use of chronic pain therapy * prophylactic use of analgesics to avoid endometriosis-related pain

Keywords: endometriosis dysmenorrhea pelvic pain dyspareunia
meaning-centered intervention for young women with weight and shape concerns

Conditions: Eating Disorder Symptom

Summary: female participants with weight and shape concerns will either receive a six-week meaning-centered intervention led by a trainer or be allocated to a waitlist condition. they will receive the same questionnaires at three time points: before the intervention, immediately after, and four weeks later. the researchers hypothesize that a meaning-centered intervention for young women with weight and shape issues will increase participants meaning in life and decrease their eating disorder symptoms immediately after the intervention and at 4-week follow-up when compared to a waitlist condition.

female first-year psychology students at the university of groningen will be screened for weight and shape concerns. those scoring in the clinically relevant range will be invited to participate in the study. after filling out the baseline measures online, the participants will be randomly allocated to a waitlist or an intervention condition. participants in the intervention condition will follow a weekly 1-hour online intervention with a trainer for six weeks, including homework assignments. in this intervention, the aim is to increase meaning in life and decrease eating disorder symptoms. all study materials will be offered in english, dutch, or german. immediately after the intervention and four weeks later, the participants will receive the same questionnaires again as at baseline. the waitlist participants will not receive any intervention during the six-week period between baseline and post-assessment, but receive the same questionnaires in the same timeframe. waitlist participants will also have the option to receive the intervention after the study has been finished.

Eligibility criteria:
inclusion criteria: * when screened with the weight concerns scale (wcs; killen et al., 1994) and when scores of all five items were adjusted to equal a maximum score of 20, leading to a total range between 0 and 100 (cf. jacobi et al., 2004), participant are eligible if they answer "always" or "often" to the item "do you ever feel fat?" or have a total score ≥ 47 on the wcs or both exclusion criteria: * current treatment for eating disorder * not fluent in english, dutch, or german
treatment response of high-dose and standard-dose rabeprazole for extra-esophageal reflux.

Conditions: Esophageal Disease

Summary: this is a single-center, randomized, open-label clinical study to assess the treatment response of high-dose rabeprazole compared with standard-dose rabeprazole in patients with extra-esophageal manifestations of gastroesophageal reflux disease.

gastroesophageal reflux disease is a condition in which reflux of stomach contents into the esophagus. this disease can be classified in to two subtypes according to the symptoms; typical symptoms such as heartburn and regurgitation, and atypical symptoms (extra-esophageal symptoms) such as chronic cough, asthma, non-cardiac chest pain, globus sensation, etc. acid suppression with proton pump inhibitors is the mainstream of therapy for the extra-esophageal manifestation as well as the typical symptoms of gastroesophageal reflux disease. however, there is controversy about the efficacy of proton pump inhibitors on extra-esophageal reflux. therefore, we aimed to assess the effect of proton pump inhibotor (rabeprazole) on the extra-esophageal manifestation of gastroesophageal reflux disease, through comparison of treatment response with high-dose and standard-dose rabeprazole.

Eligibility criteria:
inclusion criteria: * age is over 20 years old, under 80 years old, men or women * patients who had experienced extra-esophageal symptoms of gastroesophageal reflux disease more than once a week within the last month prior to the start of the study exclusion criteria: * patients administered with prokinetics, h2 receptor antagonists, proton pump inhibitors, anticholinergic drugs or non-steroid anti-inflammatory drugs prior to study in 4 weeks * patients administered with anti-thrombotic drugs * patients taking other investigational drugs or participating in other clinical studies in 4 weeks * patients with esophageal stricture, esophageal varix, barrett's esophagus, peptic ulcer or gastrointestinal bleeding * patients with zollinger-ellison syndrome * patients with any kind of malignant tumor * patients with surgery related to gastroesophageal * patients with significant cardiovascular, pulmonary, heptic, renal, hemopoietic or endocrine system primary disease * patients with neuropsychiatric disorder, alcoholism, or drug abuse * women either pregnant or breast feeding

Keywords: gastroesophageal reflux
quality of life after permanent interstitial iodine seed prostate brachytherapy

Conditions: Neoplasms, Prostate

Summary: retrospective study to analyze quality of life in men after iodine seed brachytherapy for localized prostate cancer

retrospective evaluation of quality of life data collected on men who underwent iodine seed brachytherapy at the university hospital zurich

Eligibility criteria:
inclusion criteria: * male \> 18 years of age * iodine seed brachytherapy for localized prostate cancer at the university hospital zurich exclusion criteria: * no iodine seed brachytherapy for localized prostate cancer at the university hospital zurich
nutritive sucking patterns in premature infants

Conditions: Premature; Light-For-Dates Without Mention of Fetal Malnutrition, Unspecified; Feeding Patterns

Summary: in this pilot trial, the investigators will determine the feasibility of monitoring nutritive sucking patterns to facilitate the transition from tube to oral feeding in extremely-low-birth weight (elbw) infants

in this parallel-group randomized controlled trial, elbw infants (birthweight \< 1000 grams) will be randomly assigned in a 1:1 ratio to either weekly reporting on objective measurements of sucking activity during oral feeding (intervention group) or usual care without information on sucking activity (control group).

Eligibility criteria:
inclusion criteria: * birthweight \< 1000 grams * gestational age \< 32 weeks of gestation * full enteral feeding established before or on postnatal day 21 * oral feeding initiated before or at 33 weeks of postmenstrual age exclusion criteria: * major congenital/chromosomal anomalies * patent ductus arteriosus causing significant cardiovascular symptoms * history of necrotizing enterocolitis stage 2 or greater
magnetic field application in patellofemoral pain syndrome

Conditions: Pain, Knee

Summary: the purpose of this study is to examine the effect of magnetic field application used in the treatment of patellofemoral pain.

the aim of this randomized controlled study is to examine the effect of magnetic field application used in the treatment of patellofemoral pain. the main question it aims to answer is; is magnetic field therapy applied in addition to conventional treatment effective in reducing pain in individuals with patellofemoral pain syndrome?

Eligibility criteria:
inclusion criteria: * having been diagnosed with patellofemoral pain syndrome by an orthopedic physician * volunteering to participate in the study * having pain for more than eight weeks * patients who did not undergo surgery exclusion criteria: * patients diagnosed with rheumatological disease * patients who have previously had steroid injections in the knee area * patients with entrapment neuropathy and deformity in the lower extremity * patients who are pregnant * patients suffering from scoliosis, * patients who use non-steroidal anti-inflammatory and antidepressant regularly for any reason

Keywords: pain, knee, magnetic field, physiotherapy
the use of bioscaffolds in conjunction with negative pressure therapy: a prospective randomized double-blinded trial

Conditions: Foot Ulcer, Diabetic

Summary: the primary aim of this study proposal is to test an innovative form of fetal bovine dermis bioscaffold in combination with negative pressure wound therapy (npwt) to enhance wound healing in diabetic foot ulcers.


Eligibility criteria:
inclusion criteria: * adult type 1 or 2 diabetic patients that present with foot ulcers. * ulcer size of at least 3 centimeters (cm) in diameter at its widest dimension. * ulcer depth: full thickness (absence of all epithelial layers or deeper) * adequate perfusion (at least one palpable pedal pulse or pedal bypass graft) * all ulcer durations will be eligible * patients currently receiving npwt for a diabetic foot ulcer * patients must be appropriate npwt candidates and be willing and able to sleep, ambulate, and rest with the npwt unit in place. exclusion criteria: * active foot infections * presence of any serious disease including end-stage renal failure requiring dialysis or renal transplantation or active malignant disease requiring treatment which seriously compromises the patient's ability to complete this study * patients who are pregnant * allergies to any material contained within the npwt or bioscaffold * any condition that would exclude npwt use including but not limited to active bleeding, presence of malignancy in the wound or inability to follow any of the npwt safety guidelines
pocus triage in patients presenting to the emergency department with abdominal pain

Conditions: Abdominal Pain (AP); Point of Care Ultrasound (POCUS); Triage

Summary: introduction and objective: this study aimed to reveal the effect of classical triage and bedside focused ultrasonography (pocus) in addition to classical triage on diagnosis, treatment, emergency department follow-up and its relationship with triage models in patients presenting to the emergency department with abdominal pain complaints. method: this randomized, controlled, prospective study was conducted with a total of 262 volunteer participants who were divided into two groups as 127 classical triage and 135 pocus in addition to classical triage with non-traumatic abdominal pain. the decision of which participant would be included in which group was made at a 1:1 ratio using a computer-aided randomization table. the researcher did not intervene in the clinical processes in any way. in this study, the effect of pocus application performed in addition to classical triage on clinical processes (imaging request, initial analgesia administration time, consultation request, emergency department stay and outcome) in the primary outcome and on triage systems in the secondary outcome were evaluated. ibm spss 21.0 software was used for statistical analysis of the data.


Eligibility criteria:
inclusion criteria: * present to the emergency room with abdominal pain * no history of trauma in the last 48 hours * stable hemodynamics exclusion criteria: * according to the 3-way triage, the color code is red * being under the age of 18 * being pregnant * having a history of trauma within the last 48 hours * being morbidly obese * having mental retardation * having repeated emergency room visits * being referred from the polyclinic to the emergency room with a diagnosis * filling the study form incompletely

Keywords: emergency department abdominal pain pocus triage