Kornimate/medical-research-clean huggingface dataset:
effects of polyphenol containing antioxidants on oxidative stress in diabetic patients

Conditions: Type 2 Diabetes

Summary: there has been an increase in the prevalance of type 2 diabetes in developed countries in recent years. the major contributing factors have been genetic predisposition, environmental factors, and unhealthy eating habits and stress. adverse effects on cardiovascular and renal systems after prolonged hyperglycemia bring serious burden to patients, to their families and to the society. oxidative stress has been defined as the imbalance between the production of reactive oxygen molecules and antioxidant protective molecules. it has been claimed that oxidative stress that the organism is exposed to and disturbance in anti-oxidant mechanisms have been important in the initiation of diabetes and its complications. malondialdehyde is the final product of lipid peroxidation and it is an aldehyde as well. it has been accepted that malondialdehyde has been a biomarker in measuring oxidative stress. type 2 diabetic people who are between 40 -65 years of age will be the subjects of our study. the levels of fasting glucose, hba1c, ldl, triglyceride, ast and alt and also malondialdehyte, hydrogen peroxide and oxidative stress will be determined in patients blood after making them consume a 1500 calory standard diet for 2 weeks, the patients will be randomly divided into two grouos at the end of the two weeks. group 1 will take placebo in addition to the diet, group 2 will receive polyphenol containing capsules with pomegranate extract (500 mg), green tea extract (300 mg) and a little bit of (60 mg) vitamin c for three months. at the end of three months the measurement of biochemical parameters will be repeated. patients with cardiac, renal, liver disease and smokers will be excluded from the study. patients in both groups will have a diet rich in vegetables, three servings of fruit, maximum three slices of bread with a total calory of 1500. in addition to these, both groups will have a weekly aerobic exercise regimen of 150 minutes conducted after breakfast. the biochemical results of the two groups will be compared at the end of the experiment and they will be statistically evaluated.


Eligibility criteria:
inclusion criteria: * type 2 diabetic patients between 40-65 years of age will be eligible for the study exclusion criteria: * patients with cardiac, renal, liver disease and smokers will be excluded from the study.

Keywords: oxidative stress malondialdehyde glutathione diabetes polyphenol containing antioxidants diet rich in vegetables weekly aerobic exercise
living well with rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: the purpose of the living well with ra program is to perform a proof-of-concept study and evaluate the efficacy of an internal family systems-based psychotherapeutic intervention improve rheumatoid arthritis subjects' disease activity, independence and other health outcomes. this study will also assess the efficacy of an ifs-based program in improving ra subjects' mental health symptoms. we hypothesize that the ifs model will improve ra subjects self-management of their disease and subsequently their health outcomes will improve as well as compared to a group focusing on arthritis education.

subjects will be selected from the brigham \& women's hospital arthritis center and include those enrolled in the brass study and then once recruited randomly assigned to either the ifs intervention group or the education group. both the ifs intervention and education group will participate in their respective programs simultaneously over 9 months. subject reported measures: incorporated into the questionnaires are several subject-reported measures, including: the self-compassion scale, beck depression index (bdi-ii), sf-12 health survey, state-trait anxiety inventory (stai), ra disease activity index (radai), and arthritis self-efficacy scale. these measures report emotional states, degree and location of arthritis pain, and how that pain affects their daily lives. a monthly encounter form will also be completed by the subject. physician measures: the physicians who will be monitoring subject health are blind to the study and complete the same measures for subjects in both the ifs intervention and education groups. they will complete a joint count, global assessment of health, duration of morning stiffness and acr functional status. laboratory testing: subjects will give blood at the beginning, 3, 6 and 9-month points of the program. this sample will be laboratory-tested for c-reactive protein. data collection schedule: subjects will complete a questionnaire at baseline, then at 3, 6 and 9 months. they will give blood samples and undergo a routine physical examination, focusing on their joints at the initial meeting, again at 3, 6, and 9 months into the study.

Eligibility criteria:
inclusion criteria: * active ra symptoms * member of the brass registry at the brigham and women's arthritis clinic * ability to attend group and individual sessions consistently exclusion criteria: * ra has been in remission for one year * subjects who are currently enrolled in the arthritis foundation self- management course or any similar type of course

Keywords: rheumatoid arthritis ifs psychosocial social support
cementless oxford partial knee controlled observational study

Conditions: Osteoarthritis; Avascular Necrosis

Summary: the purpose of this study is to evaluate the safety and effectiveness of the cementless oxford partial knee system.

the study is designed to document and compare the clinical and radiographic results of the cementless oxford partial knee system (investigational device) to those of the cemented oxford partial knee system (control device).

Eligibility criteria:
inclusion criteria: * have primary diagnosis of osteoarthritis or avascular necrosis limited to the medial compartment of the knee * signed informed consent for patients contributing to investigational or control if required * male or female over the age of 21 years at the time of surgery * undergone primary partial knee arthroplasty as unilateral arthroplasty or bilateral arthroplasty, simultaneously or otherwise * patients that are current residents of the united kingdom exclusion criteria: * evidence of infection, sepsis, and osteomyelitis at the time of surgery * use in the lateral compartment of the knee * rheumatoid arthritis or other forms of inflammatory joint disease * revision of a failed prosthesis, failed upper tibial osteotomy or post-traumatic arthritis after tibial plateau fracture * insufficiency of the collateral, anterior, or posterior cruciate ligaments which would preclude stability of the device * partial or full thickness cartilage disease or damage to central part of the lateral femoral condyle * osteoporosis or insufficient bone stock * metabolic disorders which may impair bone formation * osteomalacia * distant foci of infection which may spread to the implant site * rapid joint destruction, marked bone loss, or bone resorption apparent on roentgenogram * vascular insufficiency, muscular atrophy, neuromuscular disease * incomplete or deficient soft tissue surrounding the knee * charcot's disease * a fixed varus deformity (not passively correctable) of greater than 15 degrees * a flexion deformity greater than 15 degrees * refuse to sign informed consent if it is required * patients that are not current residents of the united kingdom
the necessity and optimal time for performing pars plana vitrectomy in acute retinal necrosis patients

Conditions: Acute Retinal Necrosis

Summary: the records of patients who were diagnosed with arn between april 2010 and february 2017 were analyzed.a retrospective review of the treatment options and outcomes of the these patients was performed.


Eligibility criteria:
inclusion criteria: * arn was diagnosed according to the american uveitis society diagnostic criteria (1994) exclusion criteria: -
comparison between unilateral versus bilateral stenting for malignant hilar biliary obstruction to use a lcd stent

Conditions: Obstruction of Biliary Tree; Cholangiocarcinoma; Hepatocellular Carcinoma; Malignant Lymphadenopathy; Gall Bladder Cancer

Summary: internal biliary drainage is an useful method for a control of jaundice and cholangitis to patients who had a malignant hilar obstruction due to hepatocellular carcinoma, cholangiocarcinoma, gall bladder cancer or metastatic lymphadenopathy. bilateral biliary drainage is more physiologic but technically difficult to compared with unilateral biliary drainage specially related to conformability and flexibility between using stents. there are no prospective clinical trials compared with these internal biliary drainage methods in hilar malignant obstruction using metal stent. therefore, the investigators want to compare the clinical outcome of two method: unilateral biliary stent and bilateral biliary stent


Eligibility criteria:
inclusion criteria: * age\> 18 * diagnosis of malignancy in pathology or cytology * jaundice(total bilirubin)\> 2.0 mg/dl * diagnosed malignant hilar invasion to ct or other image finding exclusion criteria: * bleeding tendency(inr\>1.5) * pregnancy * severe liver,kidney disease
automated hovering for joint replacement surgery

Conditions: Joint Disease

Summary: this will evaluate the effectiveness of automated hovering to encourage patients to be discharged to home after hip or knee replacement surgery. automated hovering includes monitoring of physical activity with an activity monitor, tracking of pain scores, daily feedback and motivational messages, social influence, and connection to clinicians as needed.

the goal of this study is to test the approach of automated hovering to encourage patients to be discharged to home safely after lower extremity joint replacement surgery (lejr). the investigators will target those patients undergoing hip or knee replacement surgery at a large urban hospital system at two different sites. the investigators aim is to increase the number of patients that are discharged to home, by providing patients with a physical activity pedometer, daily pain score tracking through bi-directional text messaging, milestone and nudge messaging for recovery, social influence, and connection to clinicians as needed for 6 weeks after surgery. eligible participants are age 18-85, with a risk assessment and prediction tool (rapt) score of 6-8 and are scheduled to undergo lower-extremity joint replacement surgery. participants will be randomized 1:1 to usual care (arm 1) and intervention (arms 2a and 2b). after enrollment with the monitoring device, participants in the intervention group will be randomized 1:1 to arm 2a (remote monitoring) or arm 2b (remote monitoring + goal-setting and social support). both intervention arms will receive the intervention for 6 weeks post-surgery.

Eligibility criteria:
inclusion criteria: * eligibility criteria: university of pennsylvania health system (uphs) patients between the ages of 18-85 with a risk assessment and prediction tool (rapt) of 6-8 and scheduled to undergo primary lower-extremity joint replacement surgery. exclusion criteria: * patients will be excluded if they do not meet all of the inclusion criteria, or if they have bilateral or revision surgery, dementia, end stage renal disease, cirrhosis, metastatic cancer, non- english speaker, or other physical impairment (ex. amputation)
gait analysis in patients with hemiplegia using insole splint.

Conditions: Gait, Hemiplegic; Splints; EMG

Summary: the goal of this clinical trial is to compare the gait of patients with hemiplegia, with or without the use of insole splint. the main questions it aims to answer are: does the insole splint improve the gait of these patients? does any difference exist in the use of muscles? participants will have to walk in the gait analysis' aisle with and without the insole splint, using wireless emg device.


Eligibility criteria:
inclusion criteria: * patients that can walk with or without the splint, having their first stroke episode at least two months ago and their hospitalisation period does not overcome six months, having also a diagnosis from a neurologist coming with a brain ct-scan. * patients must have use the insole splint during physiotherapy sessions for at least 1 week before their inclusion in the trial. * patients must be able to communicate and fully understand the instructions given by the researchers. * researchers are going to try to have a sex ratio 50/50. * patients' age is going to be between 18-70 years. * functional ambulation category: fac \> 2 * modified ashworth scale of the affected lower limb (mas): mas ≤2 * normal gait before the stroke. exclusion criteria: * peripheral neurological damage. * past or ongoing orthopedic or reumatologic disease that bothers patient's gait. * past damage of the central nervous system. * dermatologic problems or human factors that limitate the use of insole splint. * patients must not have used intramuscular botox injection recently. * patients with low motivation and low perception are also excluded.
a study of azelaic acid (aza) 15% in topical treatment of mild to moderate perioral dermatitis

Conditions: Perioral Dermatitis

Summary: the purpose of this study is to test the efficacy and safety of aza 15% gel in the treatment of mild to moderate perioral dermatitis.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of mild to moderate perioral dermatitis as diagnosed by the physician * investigator's global assessment (iga) score at baseline of 2 or 3 (on scale from 0 to 4) * 8 to 50 facial inflammatory lesions (papules, papulopustules, papulovesicles) exclusion criteria: * history of atopic dermatitis of the face * granulomatous perioral dermatitis * facial acne, rosacea, facial demodicosis * seborrheic dermatitis of the nasolabial fold, lupus erythematosus * the use of topical or systemic medications that could affect the course of treatment and/or evaluation * severe diseases likely to interfere with the conduct / planned termination of the study (e.g. cancer, cardiac infarct, unstable angina pectoris, uncontrolled diabetes) * use of fluorinated toothpaste * planned exposure to artificial or intensive natural uv light of the test area throughout the course of the study * use / planned use of cosmetic products (e.g. creams, moisturizers, make-up, fatty lipstick) in the test area during the course of the study * history of or suspected hypersensitivity to any ingredient of the study drugs * participation in another clinical study 4 weeks prior to and/or during the conduct of this study
percutaneous intramedullary k-wires fixation of pediatric shaft both bone forearm fractures

Conditions: Fracture Fixation, Intramedullary; Fracture Forearm

Summary: this study is to improving outcome of pediatric both bone forearm fractures using minimally invasive procedure by intramedullary k-wires.

most shaft injuries present no unusual challenges and require nothing more than skillful closed reduction and cast immobilization due to the unique property of the growth potential of the immature skeleton. there is a relatively high incidence of re-displacement, malunion and consequent limitation of movement. perfect anatomical reduction is not always necessary since remodeling of malunion may correct any residual deformity. angulation has been shown to affect the range of pronation and supination of the forearm. the most common indications for surgery are failure of closed reduction, open fractures, and fracture instability. when operative intervention is indicated different techniques can be employed such as intramedullary nailing, osteosynthesis with plate and screws fixation and external fixators. intramedullary nailing has been shown to produce excellent clinical results and in contrast to plate fixation is considered as a minimal invasive procedure. surgical technique of k-wires : after administration of anesthesia, surgery will be performed with the patient supine on the operating table and fracture will be analyzed with an image intensifier. in radius, the wire will be inserted by surgical drilling through lister's tubercle or the radial styloid while in ulna, the wire will be inserted through the tip of the olecranon.

Eligibility criteria:
inclusion criteria: 1. patients who are younger than the age of 10 years old from both genders and suffering from displaced fractures of shaft both bone of the forearm; 2. standard preoperative anteroposterior (ap) and lateral forearm radiographs; 3. complete clinical and radiographic data. exclusion criteria: 1. poly-traumatized patients with other associated fractures; 2. undisplaced fractures; 3. open fractures; 4. pathological fractures; 5. malignancy; 6. malnutrition; 7. chronic diseases as renal, hepatic, cardiac patients; 8. incomplete radiographic data.
efficacy and safety of crinone versus combination medication (access)

Conditions: Infertility

Summary: the study to compare to the efficacy and safety of crinone versus combination medication in infertile women receive frozen-thawed embryo transfer (fet) in artificial cycles (ac).


Eligibility criteria:
inclusion criteria: participants are eligible to be included in the study only if all the following criteria apply: * participants who will receive artificial frozen-thawed embryo transfer (fet) cycle study interventions * participants who have no more than two day 5 embryos are planned to be transferred (follow the clinical practice of the study site) * participants have received estradiol valerate for no more than 20 days * participants have a transitional-endometrium of greater than or equal to 8 millimeter * participants have normal uterine cavity * participants can give signed informed consent * participants are willing to follow the study protocol and able to complete the study exclusion criteria: * participants are willing to follow the study protocol and able to complete the study * participants with greater than or equal to three previously failed cycles of et * participants with diseases that cannot tolerate pregnancy * hydrosalpinx * severe endometriosis (endometriosis american society for reproductive medicine (asrm) criteria from 1996) * known hypersensitivity to progesterone, the excipients of crinone and duphaston vaginal bleeding of unknown origin * history of recurrent miscarriages * vaginitis * thromboembolic diseases (thrombophlebitis, thromboembolic disorder, or cerebral apoplexy) or participants with a history of these conditions * known or suspected progestogen-dependent neoplasm * participation in another clinical trial within the past 30 days * contraindications of both crinone and duphaston

Keywords: frozen-thawed embryo transfer infertility crinone duphaston chinese population
a study of the effects of molecular diagnostic directed wound gels on wound care outcomes

Conditions: Wounds

Summary: a retrospective molecular diagnostic review on wound care outcomes. the time periods include march, april, may of 2010.the retrospective review would analyze the days of healing during the timeframe, upon the introduction of molecular diagnostic testing

the null hypothesis would be that the introduction of molecular methods did not statistically affect patient outcomes. to study this hypothesis, our chief information technologist would query the database for any patients who are admitted during that time period. this period of time designated is march, april and may 2010.

Eligibility criteria:
inclusion criteria: * patients who have been treated at swrwcc during the months of march, april, or may 2010. exclusion criteria: * patients who were not treated at swrwcc during the time frame of march, april or may 2010.

Keywords: molecular methods
clinical trials of continuous oxygen therapy combined with blue light deprivation in the treatment of retinitis pigmentosa

Conditions: Retinitis Pigmentosa

Summary: the purpose of this study is to investigate the role of continuous oxygen therapy combined with blue light deprivation in prevention and control of retinitis pigmentosa, in order to find a new strategy of treatment for retinitis pigmentosa.

retinitis pigmentosa (rp) is one of of the major causes of blindness in ocular diseases.up to now, the etiology of rp remained unclear, and there are no effective therapeutic methods. several studies had showed that the retina of rp may be anoxic, and oxygen therapy, such as hyperbaric oxygen (hyperbaric oxygen, hbo) treatment, had shown a definite effect on rp. the investigators' previous researches also found that the retinal vessel oxygen saturation in patients with rp who were older than 40 years were significantly lower than normal controls, suggesting that oxygen may play an important role in the development of rp. besides, many studies have revealed that blue light could damage retina pigment epithelium cells and photoreceptor cell specially. therefore, investigators will combine continuous oxygen therapy and blue light deprivation therapy in the treatment for rp in this study, in order to find a new strategy of treatment for rp.

Eligibility criteria:
inclusion criteria: 1. severe patients with rp who meet the following criteria: (1) the edtrs visual acuity of the good eye \< 0.3 (low vision);(2) the radius of central visual field\< 10 °(low vision) 2. age range from 18 to 60 years old, sex unlimited 3. able to adhere to treatment for more than 12 months 4. willing to participate in this trial, and sign the informed consent exclusion criteria: 1. serious opacity of cornea, lens or vitreous body which can't have clear fundus examination 2. patients with severe systemic diseases who was unable to tolerate the examinations, such as heart failure, respiratory failure, sepsis, severe anemia, kidney disease, history of eye surgery and so on 3. patients who was unable to tolerate oxygen treatment, such as severe pulmonary edema, deformity of the respiratory tract, respiratory tract infection, tuberculosis, patients with pregnancy, and so on

Keywords: retinitis pigmentosa oxygen blue light