Kornimate/medical-research-clean huggingface dataset:
cognitive stimulation therapy and olderly people with mild cognitive impairment

Conditions: Mild Cognitive Impairment

Summary: the aim of this study is to examine the effect of cognitive stimulation therapy on cognitive status and apathy in elderly individuals with mild cognitive impairment.

this randomized controlled experimental study is planned for 30 october - 25 december 2023, with a total of 60 people (30 in the control group and 30 in the intervention group) at the elderly care and rehabilitation center. the data of the research were collected from the literature-based personal information form, standardized mini mental test (smmt), apathy assessment scale. approval from the clinical research ethics committee and written permission from the participants were obtained to conduct the study. individuals in the intervention group started with introduction and in the first week, pre-test administration and cst will be administered twice for 45 minutes. for the next 7 weeks, it will be carried out for one week, with the introduction and pre-test application for individuals in the control group in the first week. they will continue their daily lives in two sessions for one week and two days. they will continue their lives in the following weeks. written informed consent form will be given to all individuals in the study. it will start after information about the measurement tools is given.

Eligibility criteria:
inclusion criteria: * agree to participate in the study * being literate and speaking turkish fluently * have communication and understanding skills * standardized mini mental test result being between 18-23 points * having adequate vision and hearing functions for group participation exclusion criteria: * presence of any sensory impairment * having a physical health problem that may impair group cohesion and integrity

Keywords: cognitive stimulation therapy mild cognitive impairment cognitive status apathy
investigating the use of salaso to improve physiotherapy management of ankylosing spondylitis (as).

Conditions: Ankylosing Spondylitis

Summary: this is a pilot study to investigate the use of salaso, a web based exercise app, to increase access to physiotherapy and improve physical activity in patients attending st james's hospital rheumatology for ankylosing spondylitis (as). participants will be set up on the app and given an individual exercise programme. all individual exercises and exercise class videos will be available on the app. completion of exercises can be logged on the app and exercise compliance will then be monitored remotely by the physiotherapist through the salaso app. the physiotherapist will have a monthly telehealth session with each participant to assess progress and to address any difficulties. outcome measures will be completed at initial assessment and again at the end of the pilot study. this data will then be analysed to assess the effectiveness of the salaso app as a treatment option for as.

as is a chronic inflammatory condition affecting the spine and other joints, causing pain and stiffness. currently approximately 150 people attend saint james's hospital rheumatology department for management of their condition. physiotherapy plays a key role in this management. as this is often a younger patient population, it can be challenging for them to attend appointments due to work and family commitments. it is envisaged that this pilot will enhance treatment options for all participants. the aims of this study are: to improve use of exercise and physical activity using an online exercise application; to improve self-management skills in monitoring progress and ability to exercise independently using an online exercise application; to provide an online appointment review option to patients who are unable to attend physiotherapy appointments in st james's hospital. descriptive statistics will be used to record and analyse the study data, using spss software.

Eligibility criteria:
inclusion criteria: * confirmed diagnosis of ankylosing spondylitis exclusion criteria: * previous spinal surgery * spondylolisthesis * unwillingness to participate * unable to complete self-report questionnaires * progressive neurological deficit * neurological disease * cauda equina syndrome * unable to exercise on medical grounds

Keywords: ankylosing spondylitis; physiotherapy; salaso
effects of diet and exercise on circadian glycemia

Conditions: Glucose Intolerance

Summary: specific aims of the study are: 1. to evaluate whether a 24-h exposure to a 25%-carbohydrate diet will reduce postprandial glycemia to the same extent in the evening (19 h) as in the morning (7 h),. and 2. to determine whether one hour of post-meal moderate intensity exercise (at 50% of maximal effort) will further reduce postprandial glycemia. the outcome measures are: plasma concentrations of glucose, insulin, glucose-dependent-insulinotropic peptide (gip), leptin, and the ketone body beta-hydroxybutyrate.

the two hypotheses in this study are: 1. a 24-h exposure to a 25%-carbohydrate diet will reduce postprandial glycemia to the same extent in the evening (19 h) as in the morning (7 h), and 2. one hour of moderate-intensity exercise (at 50% of maximal effort) will further reduce postprandial glycemia to the same extent in the evening (19 h) as in the morning (7 h). eight postmenopausal subjects (age 58.5 years, bmi 25.6 kg/m2) participated in 4 24-h long crossover trials, two terminating at 7h and the other 2 at 19h. at each circadian time one trial required 60 minutes of moderate-intensity exercise (50% of maximal effort), and the other two involved no exercise. three 25%-carbohydrate meals prepared by the michigan clinical research unit (mcru) kitchen, were eaten at subjects' home, and the fourth was eaten 20 minutes after subjects' arrival at mcru at either 19 h or 7 h. blood was collected from antecubital catheter at 10-minute intervals until 23:20 h or 11:20 h, respectively.plasma was treated with protease inhibitor to preserve gip, frozen at -80o c until glucose measurements by glucose oxidase, hormone measurements by chemiluminescence, and ketone measurements by abbott meter strips. exercise intensity was determined before the exercise trials on a treadmill from oxygen consumption (vo2) and carbon dioxide production (vco2) by subjects walking on a treadmill at 3 mph with the treadmill slope increased by 2% every 3 minutes. maximal effort was established when respiratory exchange ratio (vco2/vo2) reached or exceeded 1. the treadmill speed and slope at half maximal effort was used during the one-hour exercise bout which was initiated 40 minutes after the start of the meal.

Eligibility criteria:
inclusion criteria: * postmenopausal * normal blood glucose * no cholesterol medication * age between 50 an 65 years * overweight but not obese * bmi between 25 and 30 kg/m2 * weight-stable during past 6 months * exercise less than 20 minutes three times a week exclusion criteria: * metabolic disease other than hormonally-corrected hypothyroidism * musculo-skeletal disability that would preclude exercise * smoker * do not meet inclusion criteria
evaluation of a psychoeducation program for families caregivers of schizophrenic patients : randomized study in two arms

Conditions: Schizophrenia; Mental Disorder; Educational Problems; Family Relations; Relapse; Medication Adherence; Psychiatric Disorder; Psychiatric Hospitalization

Summary: the involvement of family members is crucial and improves the prognosis of psychiatric patients and reinforces therapeutic adherence and reduces the frequency of relapses. for schizophrenia, the scientific literature clearly shows that it's in the interest of the patient to offer to his family a psychoeducational program. therapeutic education programs are now part of the recommendations of good clinical practice and in the french health through the law n ° 2009-879 of july 21, 2009 on the reform of the hospital and relating to patients, health and territories.

objectives we conducted a randomized study in two groups to evaluate the impact of a psychoeducational program for caregivers. methods 60 patients with a dsm-v diagnosis of schizophrenia and their families' caregivers are recruited. families' caregivers are randomly assigned to receive either a 6 session psychoeducation program, or no psychoeducation. baseline evaluations: patients: symptomatology (panss), medication adherence (mars); families' caregivers: quality of life (s-cgqol), burden (zarit), knowledge of disease (kast), therapeutic alliance (4pas caregivers), depression (ces-d), medication adherence (crs).

Eligibility criteria:
inclusion criteria: * diagnosis of schizophrenia, based on icd-10 (f20 to f29) * receive in-patient treatment at hospital (or medical center linked to charles perrens hospital) * be the caregiver or parent of the patient * patient informed of the diagnosis of his disease exclusion criteria: * mental retardation or other diagnoses that could affect the ability to answer questionnaires, after the acute schizophrenia psychosis is controlled * suicidal ideation * non-comprehension of the french language

Keywords: schizophrenia psychoeducation program family caregiver relapse medication adherence burden
obstructive sleep apnea in pulmonary embolism

Conditions: Pulmonary Thromboembolism; Obstructive Sleep Apnea

Summary: obstructive sleep apnea (osa) is a clinical syndrome characterized by repetitive closure of the airway and frequent awakenings during sleep. repeated episodes of hypoxia, decrease in intrathoracic pressure, increased venous return and venous stasis, damage to vascular wall may ensue. an increased tendency for coagulation has also been reported in osa. venous stasis, vascular endothelial activation and hypercoagulability are also known risk factors for thromboembolism. all of these pathophysiologic changes in osa may predispose patients for the development of pulmonary embolism (pe) however there is limited data about role of thromboembolic events in osa.


Eligibility criteria:
inclusion criteria: * all consecutive patients diagnosed with pulmonary embolism exclusion criteria: * less than 18 years of age * any restrictive or obstructive lung disease

Keywords: sleep disordered breathing gender hypercoagulability
phase 1 study of cm082 (x-82) tablets in advanced cancer patients in china

Conditions: Advanced Cancer

Summary: this is a phase i dose-escalation study to evaluate the safety, tolerability, and pharmacokinetics of cm082 tablets in chinese patients with advanced solid tumors.

this is a phase i dose-escalation study to evaluate the safety, tolerability, and pharmacokinetics of cm082 tablets in chinese patients with advanced solid tumors. after the maximum tolerated dose (mtd) or the optimal biological dose is identified, an expansion cohort of \~20 advanced renal cell carcinoma patients will be enrolled to further characterize the safety and tumor response by ct.

Eligibility criteria:
inclusion criteria: * histologically or cytologically confirmed diagnosis of advanced solid tumor malignancy that is not responsive to standard therapies or for which there is no effective therapy. * eastern cooperative group (ecog) performance status score of 0 or 1. * life expectancy of at least 12 weeks. * no immuno deficiency. * adequate organ system function, defined as follows: * absolute neutrophil count (anc) ≥1.5 x 10\*\*9/l * platelets ≥100 x 10\*\*9/l * hemoglobin ≥10 g/dl * total bilirubin ≤1.5 times the upper limit of normal (uln) * alanine aminotransferase (alt) and aspartate aminotransferase (ast) ≤1.5x the upper limit of normal (uln) if no liver involvement or ≤2.5x the upper limit of normal with liver involvement. * creatinine ≤ 1.5 x uln. * at least 4 weeks or 5 half-life after receiving cancer therapy (i.e., chemotherapy, radiation therapy, immunotherapy, biologic therapy, hormonal therapy, surgery and/or tumor embolization. * willingness and ability to comply with trial and follow-up procedures. * ability to understand the nature of this trial and give written informed consent. exclusion criteria: * not recovered from prior anti-cancer therapy or surgery. * have taken strong cytochrome p450 3a4 inhibitors or inducers in the last 2 weeks. * concomitant use of drugs with a risk of causing prolonged corrected qt interval and/or torsades de pointes. * patients with a history of intolerance to, or significant toxicity with, vegfr tyrosine kinase inhibitor(s) (tki). * females who are pregnant or breastfeeding. * those in reproductive ages who refuse to use contraception. * those with concurrent condition(e.g. psychological, neuronal, cardiovascular, respiratory conditions or infections) that in the investigator's opinion would jeopardize compliance with the protocol. * patients with known central nervous system (cns) metastases. * presence of active gastrointestinal (gi) disease or other condition that will interfere significantly with the absorption, distribution, metabolism, or excretion of cm082 (x-82). * patients with known gi disorders such as vomiting, diarrhea. * patients who are hepatitis b virus positive. * drug abuser.

Keywords: advanced cancer
corneal endothelial cell loss after phacoemulsification compared with extracapsular cataract extraction

Conditions: Senile Cataract

Summary: the investigators will compare between the endothelial cell loss after phacoemulsification and extracapsular cataract extraction in management of senile cataract

age related cataract is believed to be the main cause of reversible blindness worldwide and in developing countries. population-based studies have reported that cataract is responsible for 47.8% to 51% of all global blindness. several studies compared phacoemulsification and conventional extracapsular cataract extraction regarding several aspects such as postoperative inflammation and visual rehabilitation. studies proved that phacoemulsification has faster rehabilitation ,less astigmatism and better postoperative vision .however, extracapsular cataract extraction is still the operation of choice in some cataract cases. the normal corneal endothelium is a single layer of uniformly sized cells with a predominantly hexagonal shape. adult density of approximately 2400 - 3200 cells/mm².the number of cells decreases at about 0.6% per year and neighbouring cells enlarge to fill the space as the cells cannot regenerate.the minimum cell density necessary for adequate function is in the range of 400 to 700 cells/mm2. the effect of cataract surgery on corneal endothelium is an important factor that affects postoperative vision .however, it is accepted all over the world that there is definite loss of some endothelial cells with all techniques of cataract surgery. previously, cataract surgery caused enormous loss of endothelial cells , but with enhancement of equipment and surgical techniques, cataract surgery today results in 6-14%loss of endothelial cells. specular microscopy is a noninvasive photographic technique that allows visualization and analysis of corneal endothelium. specular microscopy is used to show cell count and cell shape in the scanned area.

Eligibility criteria:
inclusion criteria: * cases of senile cataract of both sexes will be included in this study exclusion criteria: * corneal endothelial pathologies such as fuch's dystrophy * complicated cataract * cataract with history of trauma * coexisting eye pathology
"domino" therapy treat the infection around the prosthesis after the limb salvage surgery of bone tumor

Conditions: Infection

Summary: tumor resection and prosthetic replacement have become the treatments of choice for malignant bone tumors. infections are the main cause of failure of limb salvage surgeries. therefore, treatment of infections around prostheses after limb salvage is important, but is also challenging. our research team designed a "domino" sequential treatment plan to treat postoperative infections around tumor prostheses and evaluated its efficacy.

malignant bone tumors are associated with high mortality and disability rates. developments over the past 20 years have made tumor resection and prosthetic replacement the preferred surgical treatments. prosthetic reconstruction maintains the continuity of limb bones and leads to better joint function, but is often associated with complications such as loosening, fracture, and infection of the prosthesis. among these, infection is the most important cause of failed limb salvage surgery. postoperative infection rates of 5-25% have been reported in the literature. infection is also the main cause of secondary amputation. therefore, it is important to address infections around the prosthesis after limb salvage. investigators retrospectively analyzed the use of prosthesis-preserving sequential therapy to treat patients with peripheral prosthesis infections after bone-tumor limb salvage. investigators summarized and analyzed the treatment processes and performed laboratory, imaging, and functional evaluations after treatment. the purpose was to introduce a new type of domino sequential treatment plan for treating postoperative infections of tumor prosthesis, and evaluate the technical points of the plan, and prognosis over medium- and long-term follow-ups.

Eligibility criteria:
inclusion criteria: * deep postoperative infections after replacement of a tumor-type prosthesis according to the 2011 diagnostic criteria of the musculoskeletal infection society (msis) ; * treated with debridement and lavage with prosthesis preservation, local application of antibiotics, and no loosening during intraoperative exploration; * with complete data for the main indicators (routine blood test results, c-reactive protein \[crp\] level, erythrocyte sedimentation rate \[esr\], x-ray and ct scans of the surgical site, and the musculoskeletal tumor society \[mtst\] score). exclusion criteria: * underwent debridement without prosthesis preservation; * with a loose prosthesis during intraoperative exploration; * with poor soft tissue coverage, such that complete free muscle flap coverage could not be achieved; patients with renal insufficiency/failure (serum creatinine ≥ 2.0 mg/dl); patients with uncontrolled diabetes mellitus (hemoglobin a1c level \> 8%); * in poor general condition who could not tolerate surgery.

Keywords: bone tumor limb salvage surgery infection therapy effect
efficacy and safety of eletriptan for the treatment of migraine in patients not satisfied with rizatriptan therapy

Conditions: Migraine

Summary: to assess the efficacy and safety of eletriptan for migraine headaches in subjects who were not satisfied with rizatriptan therapy


Eligibility criteria:
inclusion criteria: * diagnosis of migraine headache according to international headache society criteria and migraine headaches for at least 1 year * eletriptan naive * previously treated with rizatriptan and failed to achieve a satisfactory response within the past 12 months exclusion criteria: * non-migraine headaches on average more than 6 days per month or have less than 24 hours of freedom from headache between migraine attacks * migraine attacks that are atypical or chronic daily headaches * a history of migraine with prolonged aura, familial hemiplegic migraine, basilar migraine, migrainous infarction, migraine aura without headache, migraine with acute onset aura
nlit and outcomes in hnc survivor-caregiver dyads

Conditions: Head and Neck Cancer; Caregiver Burden; Health Knowledge, Attitudes, Practice

Summary: the goal of this observational (cross-sectional) study is to better understand nutrition literacy in survivor-caregiver dyads and its impact on nutrition related outcomes and quality of life. we're interested in finding out how much they know about nutrition and how this might relate to their overall health, body composition, functional status, and overall well-being. we will target post-treatment head and neck cancer survivors and a paired informal caregiver. the main questions we aim to answer are: * how does the nutrition literacy of both the survivor and caregiver relate to their sociodemographic, behavioral, and clinical characteristics? * how dyadic nutrition literacy influence individual nutrition outcomes like skin carotenoid levels, body composition, and functional status? * does the shared nutrition knowledge (nutrition literacy) of both the survivor and caregiver impact their quality of life together? participants will: answer questions about their knowledge of nutrition. have their nutritional health status checked. use a non-invasive device to measure skin carotenoid content to validate self-reports of fruit and vegetable intake. have a simple and painless test to measure their body composition - like how much muscle and fat they have. do some physical tests like grip strength and walking to measure their physical ability. answer questions about their general well-being and lifestyle, like exercise and diet. (for the survivor) share details about their cancer, its treatment, and their overall well-being. (for the caregiver) answer questions about their role in taking care of the survivor, and their involvement in care routine such as food shopping and cooking.


Eligibility criteria:
inclusion criteria: * survivors and their caregivers will be eligible to participate if the survivor 1) has a history of oral cavity, pharyngeal, or laryngeal cancer, 2) is between 6 months - 4 years post-primary oncology treatment, 3) has no evidence of disease, 4) has an informal caregiver living in or out of the home who has a shared or primary role in food procurement and/or preparation, 5) no current use of feeding tube as the primary source of nutrition and can consume food orally, 6) age 18+, 7) english-speaking. survivors and their caregivers will not be eligible to participate if either has 1) dementia or organic brain syndrome; 2) severe emotional distress; 3) active schizophrenia, 4) another diagnosis of cancer in the past five years (not including skin or cervical cancer in situ). exclusion criteria: * adults unable to consent * individuals who are not yet adults (infants, children, teenagers) * pregnant women * prisoners
safety & efficacy of eculizumab in the prevention of amr in sensitized recipients of a kidney transplant from a deceased donor

Conditions: Stage V Chronic Kidney Disease

Summary: primary objective: to evaluate the safety and potential efficacy of eculizumab to prevent amr in sensitized recipients of deceased donor kidney transplants.


Eligibility criteria:
inclusion criteria: 1. male or female participants ≥18 years old. 2. participants with stage v chronic kidney disease who received a kidney transplant from a deceased donor to whom they were sensitized. 3. history of prior exposure to hla (human leukocyte antigen): * prior solid organ or tissue allograft * pregnancy * blood transfusion * prior exposure to specific donor's hla exclusion criteria: 1. has received treatment with eculizumab at any time prior to enrolling in this study. 2. blood type (a, b, and o blood glycoproteins-blood type) incompatible with deceased donor. 3. history of severe cardiac disease. 4. prior splenectomy.