Kornimate/medical-research-clean huggingface dataset:
facilitation of brain plasticity for language recovery in patients with aphasia due to stroke

Conditions: Stroke; Aphasia

Summary: the purpose of this study is to investigate effects of tdcs stimulation in the left primary motor area followed by naming therapy to improve language functions in patients with aphasia in the sub-acute stage.

transcranial direct current stimulation (tdcs) is a simple and non-intrusive method that has demonstrated promising results in language rehabilitation of patients with aphasia. various studies have used different stimulation set-ups, some based on prior structural and functional brain mapping in order to choose the optimal stimulation region. an additional approach that was found beneficial is stimulation of the left primary motor area (m1). a major advantage of this approach is its relative simplicity that may increase the application of this intervention in clinical settings. this intervention approach has been studied in patients with chronic aphasia and targeted on naming ability. in the current study the investigators aim to study the influence of a stimulation set-up at m1 in stroke patients suffering from aphasia that are in the sub-acute stage. in addition the investigators aim to study additional language functions including pragmatics and grammar. the study will include 30 patients suffering from aphasia which are in the sub-acute stage. the patients will undergo complete language assessments at 3 time points: baseline, post intervention (third week from recruitment) and one month follow-up. the study group will include 15 patients that will undergo tdcs at the left m1 region followed by naming therapy. the intervention will be given daily for duration of two weeks (5 days/week). the control group will include 15 patients that will undergo the same protocol apart from sham tdcs. the effect of the intervention will be examined taking into account the extent and location of the brain damage on language functions.

Eligibility criteria:
inclusion criteria: * patients post stroke with right hemiplegia and aphasia with cognitive capacity to understand instructions and at the aphasia cut-of level defined by "shemesh" assessment exclusion criteria: * unstable clinical state, craniotomy, epilepsy, heart pacer or lack of cooperation

Keywords: tdcs aphasia
pilot study of the rotavirus vaccine in infants with intestinal failure

Conditions: Intestinal Failure; Rotavirus Vaccines

Summary: the purpose of this study is to assess the safety and immune response of the rotavirus vaccine in infants who have undergone abdominal surgery.


Eligibility criteria:
inclusion criteria: * infants with one of the following diagnoses: * necrotizing enterocolitis requiring operation; * congenital atresia of the intestine; * gastroschisis; * midgut volvulus requiring bowel resection; or * long-segment intestinal aganglionosis * minimum gestational age of 35 weeks at time of first vaccine dose exclusion criteria: * immunocompromise secondary to hiv infection or immunodeficiency state * active use of corticosteroid or other immunosuppressive agents * active infection as defined by fever \> 38°c within 24 hours, positive blood culture within 7 days, or positive urine culture within 3 days of enrollment * severe malnutrition as defined by serum albumin \< 2.0 mg/dl or serum prealbumin \< 6 mg/dl.

Keywords: intestinal failure rotavirus vaccine infants
patient-centered decision support for eosinophilic esophagitis

Conditions: Eosinophilic Esophagitis

Summary: the study team is conducting this project to learn more about how patients with eosinophilic esophagitis (eoe) like to use and receive educational materials about treatment options and treatment decision making. this study will assess the efficacy of a decision support intervention to make decisions about treatment and disease management for patients with eoe and will assess the feasibility and acceptability of the intervention to inform future r01-level studies. the study team hypothesize that deploying the intervention will be feasible, and it will demonstrate high acceptability among eoe patients. additionally, that patients that use the intervention (vs general education about eoe) will report greater treatment knowledge, increased readiness to choose a therapy, adherence to therapy, and follow-up.


Eligibility criteria:
inclusion criteria: * new eoe patient evaluations ≥18 years old at university of michigan (um) that have an upcoming outpatient visit in a um-gastroenterology or allergy \& immunology clinic, * able to speak and read english. exclusion criteria: * prisoners and institutionalized individuals due to logistical limitations for use of a web app and follow-up interactions in these populations. * patients that have significant cognitive or visual impairment that limits interaction with the decision aid (da) * patients that are terminally ill * patients that do not have an email address or reliable access to the internet

Keywords: tailored educational materials general educational materials online surveys decision aid
measuring of neuro-visual functionality with ocusweep

Conditions: Visual Impairment

Summary: the aim of this study is to measure visual acuity, contrast sensitivity and visual field by sap-method using a novel device ocusweep compared to currently widely used methods. addition to that, the aim is to validate a novel perimetry method (visual search test, vst) which is based on reaction times in visual decision- making task, where the subject is allowed to move eyes and where the fixation is verified by the subject himself in contrast to standard automatic perimetry (sap) where prolonged stationary fixation and external fixation monitoring apparatus is required. reaction-time based visual field device ocusweep is compared to generally used sap methods. those tests will be done for healthy volunteers and for persons with diagnosed eye or brain disease. ocusweep ocurt vision based choice reaction time test is validated for test repeatability and compared to trail making test (tmt), useful field of view (ufov) and vienna test system (vts) reaction time tests. to evaluate the ability to detect unreliable results, ocurt test is also done under cognitive load and with instructions to cheat the test.


Eligibility criteria:
inclusion criteria: * healthy volunteers * persons suffering diagnosed eye disease * persons suffering diagnosed brain disease exclusion criteria: * no diabetes * only one diagnosed disease
autonomic nervous system alteration induce by sepsis: assessment and prognosis impact

Conditions: Septic Shock; Severe Sepsis

Summary: severe sepsis and septic shock are causes of admission in intensive care units.modification of natriuretic peptid including nt-probnp and cardiac autonomic nervous system alteration are reported in sepsis shock and severe sepsis and seems to link to patient prognosis admitted to intensive care units.

our principal aim is to characterize modulation of cardiac sympathic nervous system in sepsis through the study of sinusal change and myocardiac fixing of mibg. the second aim is 1)to assess links between alteration of cardiac sympathic nervous system and nt-probnp variations in sepsis and 2)to know prognostic impact in sympathic nervous system compare to ntprobnp.

Eligibility criteria:
inclusion criteria: * patient over 18 years admitted in intensive care unit and having severe sepsis criteria or septic shock documented or suspected define as bone criteria * hemodynamically stable situation * sinusal rhythm * patient for social security exclusion criteria: * minors * patient under guardianship or trusteeship * pregnant or lactating women * diabetic * cardiomyopathy known and/or treated or detect in admission * electro-systolic process permanent or transitory * neurological history or degenerative pathology * chronic respiratory insufficiency * chronic renal insufficiency

Keywords: autonomic nervous system sepsis shock severe sepsis sinusal change myocardiac fixing ntprobnp patient in intensive care unit with sepsis shock or severe sepsis
kinematics of knees of patients with tumor around knee after microwave ablation with plate internal fixation

Conditions: Knee Tumor; Microwave

Summary: the aim of this study is to investigate kinematics of knees of patients with tumor around knee after microwave ablation with plate internal fixation


Eligibility criteria:
inclusion criteria: 1. age \< 40. 2. body mass index \< 30. 3. for controls, no history of major injury or surgery in lower limbs; no symptoms of lower limbs; physical examination to test the lower limbs to be healthy. 4. for mf group, patients with tumor around knee after microwave ablation with plate internal fixation for 6 months or more. exclusion criteria: 1. body mass index \>30. 2. for controls, injury or surgery in hip/knee/ankle. 3. for mf group, injury or surgery in hip/ankle; 4. neuropathic disease. 5. muscular disease. 6. lack ability to finish the procedure physically or mentally. 7. easy to fall. 8. any other conditions that can influence gait parameters of the lower limbs.

Keywords: knee tumor microwave gait
adaptation of linehan's biosocial model to emotional dysregulation in autism spectrum disorder

Conditions: Autism Spectrum Disorder

Summary: linehan's biosocial model conceptualizes the factors at play in the development of emotional dysregulation (ed), that is, difficulty regulating one's emotions, in borderline personality disorder (bpd). the model explains ed as the result of the interaction between the person's biological emotional vulnerability and their exposure to early invalidating experiences from those around them. recently, ed has been shown to be prevalent in autism spectrum disorder (asd). the objective of the study is to propose an adaptation of linehan's model to the specificities of asd to conceptualize the factors contributing to ed in the context of this disorder. to do this, the investigators will carry out a narrative literature review, as well as an illustrative case conceptualization based on the proposed model.


Eligibility criteria:
inclusion criteria: * adult subjects (≥18 years old) * having been diagnosed with asd without intellectual disability * presenting severe ed with self-harming behaviors and/or suicidal behaviors exclusion criteria: - subjects not meeting the study eligibility criteria

Keywords: autism disorder
commercial or open source closed loop impact on pregnancy study

Conditions: Type 1 Diabetes; Pregnancy, High Risk; Insulin Dependent Diabetes; Pregnancy Related

Summary: the goal of this observational study is to better understand what happens when pregnant people with type 1 diabetes (t1d) use automated insulin delivery (aid) systems. the main questions this study aims to answer are: * what are the maternal and neonatal outcomes with aid system use in pregnancy? * what are the glycemic outcomes with aid system use in pregnancy? * what are the behavioral and emotional outcomes with aid system use in pregnancy? researchers will compare pregnant people who use commercial aid systems and pregnant people who use open source aid systems to see if outcomes are different with these different types of systems. participants will be asked to remotely share their aid system data with the research team; complete online surveys regarding behavioral and emotional health; and sign an authorization to release health information to allow the research team to access medical records.


Eligibility criteria:
inclusion criteria: * pregnant * diagnosis of type 1 diabetes (t1d) prior to pregnancy * active use of automated insulin delivery (aid) system exclusion criteria: * diagnosis of other forms of diabetes (gestational diabetes, type 2 diabetes, monogenic diabetes)
a research study of mk0633 in patients with chronic obstructive pulmonary disease (copd)(0633-009)(completed)

Conditions: Chronic Obstructive Pulmonary Disease (COPD)

Summary: a clinical study to evaluate the efficacy and safety of mk0633 in patients with chronic obstructive pulmonary disease (copd).


Eligibility criteria:
inclusion criteria: * documented copd defined by clinical history and spirometry, with symptoms including dyspnea, wheezing, chest tightness, cough, sputum production, or nocturnal awakening * male or postmenopausal females 40 -75 years of age exclusion criteria: * impaired renal function * history of chronic liver disease or persistent liver function test (lft) abnormalities * history of recent cardiovascular clinical event * evidence of another clinically significant, active pulmonary disorder such as bronchiectasis or asthma
breakfast for young women

Conditions: Obesity; Wolman Disease; Nutrition

Summary: investigators will in a crossover study test the health effects of eating a dairy-based protein-rich breakfast, isocaloric carbohydrate-rich breakfast or no breakfast in young overweight women. determination of satiety and hunger using visual analog scores (vas), collection of blood samples and 2x 24 hours food logs will be collected.

this study is a single-blind randomized cross-over trial with 30 women aged 18-30 years, each completing three trials. participants will consume either dairy-based protein-rich breakfast, isocaloric, fiber matched, fat matched, carbohydrate-rich breakfast or no breakfast in randomized order. three hours later a standardized ad libitum lunch will be served. blood samples will be collected (pre, 10 min, 30 min, 60 min, 120 min, 175 min after breakfast) and vas rating hunger, satiety and desire to eat will be determined (pre, during breakfast, 10, 30, 60, 90, 120, 180 min, during lunch, after lunch). twenty-four hour food logs on the day before the test day and on the test day will be collected. participants will be characterized by determining height (cm), weight (kg), and body composition by a dual-energy x-ray (dxa) scan before the first test day.

Eligibility criteria:
inclusion criteria: * body mass index \> 25 * age 18-25 years * regular exercise \< 5 hour per week exclusion criteria: * illness and use of medication affecting the study outcomes * allergy towards lactose or gluten * weightloss/gain \>5kg the last 6 months * dieting * eating disorder * pregnancy * breast feeding * unable to speak and understand danish
combination chemotherapy in treating patients with recurrent or refractory cervical cancer

Conditions: Cervical Cancer

Summary: rationale: drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. combining more than one drug may kill more tumor cells. purpose: phase ii trial to study the effectiveness of combination chemotherapy with cisplatin and vinorelbine in treating patients with refractory or recurrent squamous cell cervical cancer that has not responded to local therapy.

objectives: i. determine the activity of cisplatin and vinorelbine in terms of response rate, duration of response, time to treatment failure, and survival in patients with advanced, persistent, or recurrent squamous cell carcinoma of the cervix. outline: this is a multicenter study. patients receive vinorelbine iv over 6-10 minutes on days 1, 8, 15, and 22 and cisplatin iv over 4 hours beginning after completion of vinorelbine infusion on day 1. courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity. patients are followed every 3 months for 2 years and then every 6 months for 3 years. projected accrual: a total of 28-62 patients will be accrued for this study within approximately 20 months.

Eligibility criteria:
disease characteristics: histologically proven advanced, persistent, or recurrent squamous cell carcinoma of the cervix that failed local therapy and is considered incurable bidimensionally measurable abdominal, pelvic, or other lesion by palpation, x- ray, or ultrasound if sole site of measurable disease previously irradiated, then documented disease progression at that site required patient characteristics: age: any age performance status: gog 0-2 karnofsky 60%-100% hematopoietic: wbc at least 3,000/mm3 granulocyte count at least 1,500/mm3 platelet count at least 100,000/mm3 hepatic: bilirubin no greater than 1.5 times normal sgot no greater than 3 times normal alkaline phosphatase no greater than 3 times normal renal: creatinine no greater than 1.4 mg/dl creatinine clearance at least 50 ml/min if creatinine greater than 1.2 mg/dl other: no clinically significant infection no preexisting, clinically significant peripheral neuropathy unless due to cancer no other prior or concurrent malignancy except nonmelanomatous skin cancer no psychological, familial, sociological, or geographical condition that would preclude compliance prior concurrent therapy: biologic therapy: not specified chemotherapy: no prior chemotherapy except for radiosensitization endocrine therapy: not specified radiotherapy: see chemotherapy recovered from the toxic effects of any recent radiotherapy surgery: recovered from the toxic effects of any recent surgery

Keywords: recurrent cervical cancer stage ivb cervical cancer cervical squamous cell carcinoma
efficacy of ametop cream in reducing pain of local anesthetic infiltration

Conditions: Pain

Summary: ametop is a numbing cream used to ease the pain of having blood drawn or an iv inserted. it is safe and virtually none enters the blood stream. it's effectiveness at reducing the pain of the freezing injection prior to epidural/ spinal anesthesia in pregnant women has not been studied.

we propose to randomize 70 women to have either the numbing cream or a similar looking moisturizing cream placed on their lower back before their anesthetic. they will rate the discomfort of the freezing injection allowing us to compare the two groups and determine if the numbing cream is effective.

Eligibility criteria:
inclusion criteria: * any pregnant subject undergoing an elective procedure under neuraxial anesthesia. exclusion criteria: * any contraindication to neuraxial anesthesia * subjects in labour
development and validation of a prediction model for aki following cisplatin-based hipec in patients with ovarian cancer

Conditions: Ovarian Cancer; AKI - Acute Kidney Injury

Summary: ovarian cancer is the most lethal malignant tumor of the female reproductive system. cytoreduction surgery(crs) combined with chemotherapy is the primary method for treating ovarian cancer, and complete tumor resection is an important means to improve prognosis. it has been demonstrated that the use of cisplatin for hyperthermic intraperitoneal chemotherapy (hipec) following crs can significantly improve the prognosis of some patients with ovarian cancer. however, hipec with cisplatin can lead to acute kidney injury (aki), a serious complication that can seriously affect the patient's short- and long-term prognosis. nccn guidelines recommend the use of sodium thiosulfate in all patients receiving hipec. this study intends to retrospectively collect clinical characteristics of patients to establish a prediction model for kidney injury, with a view to screening those at high risk of kidney injury for use of sodium thiosulfate for nephrotoxicity rescue in cisplatin hipec.


Eligibility criteria:
inclusion criteria: * patients who received hipec with cisplatin following cytoreductive surgery. * patients diagnosed with ovarian cancer pathologically. * figo stage iii-iv. exclusion criteria: * use of renal protective drugs such as sodium perthiosulfate. * any grade of chronic or acute renal disease or other serious complications existed before hipec. * patients with single kidney.
avastin and chemotherapy followed by a kras stratified randomization to maintenance treatment for first line treatment of metastatic colorectal cancer.

Conditions: Colorectal Cancer

Summary: patients with metastatic colorectal cancer will be treated with chemotherapy according to investigators choice. in addition to chemotherapy treatment, treatment with bevacizumab will be given concomitantly. this treatment will continue during 18 weeks. meanwhile, the patients kras status will be tested. after having fulfilled these 18 weeks of induction treatment, patients who has responded (complete response/partial response versus stable disease) will be randomized to maintenance treatment. patients with kras wt will be randomized to either bevacizumab alone, or to bevacizumab and erlotinib. patient with kras mutation will be randomized to either bevacizumab, or metronomic capecitabine. translational research is performed, with purpose to find predictive factors in blood and tumor tissue.


Eligibility criteria:
inclusion criteria: * untreated metastatic colorectal carcinoma * age 18 yrs or over * measurable disease according to response evaluation criteria in solid tumors (recist criteria) * ecog performance status 0 or 1 * life expectancy more than 3 months * adequate haematological, renal and liver function * tumor tissue available for determination of kras mutational status * blood sample and paraffin embedded tumor tissue for translational research exclusion criteria: * adjuvant therapy within 6 months * cns metastases * clinically significant atherosclerotic vascular disease

Keywords: untreated first line chemotherapy maintenance treatment kras wt kras mutated anti-angiogenetic treatment metronomic capecitabine bevacizumab erlotinib translational research
abdominal aortic aneurysms and pseudoexfoliation syndrome

Conditions: Abdominal Aortic Aneurysms; Pseudoexfoliation Syndrome; Hypertension

Summary: conflicting results have been reported concerning the association of pseudoexfoliation syndrome (pxf) and abdominal aortic aneurysms (aaa). schumacher et al. reported an association between aaa and pxf, with no consideration of grade. however, a later study did not confirm the association between aaa and pxf. the present study aimed at comparing the relative prevalence of pxf in patients suffering from aaa and in age-matched hypertensive patients.


Eligibility criteria:
inclusion criteria: * presence of abdominal aortic aneurism * systemic hypertension without abdominal aortic aneurism over 60 years old exclusion criteria: * unknown status for abdominal aortic aneurism

Keywords: abdominal aortic aneurysms pseudoexfoliation syndrome glaucoma
evaluation of the performance of an adhesive strip

Conditions: Ileostomy - Stoma

Summary: this study investigated the performance of a new adhesive strip when impacted by output


Eligibility criteria:
inclusion criteria: 1. have given written informed consent 2. be at least 18 years of age and have full legal capacity 3. have had an ileostomy for more than one year 4. have intact skin on the area used in the evaluation 5. has an ileostomy with a diameter up to (≤) 35 mm 6. have a peristomal area accessible for application of test product (assessed by investigator) exclusion criteria: 1. currently receiving or have within the past 2 month received radio- and/or chemotherapy 2. currently receiving or have within the past month received topical steroid treatment in the peristomal skin area or systemic steroid (tablet/injection) treatment. 3. are pregnant or breastfeeding 4. having dermatological problems in the peristomal- or abdominal area (assessed by investigator) 5. participating in other interventional clinical investigations or have previously participated in this investigation