Kornimate/medical-research-clean huggingface dataset:
tianjin inpatient acute myocardial infarction registry

Conditions: Myocardial Infarction, Acute

Summary: acute myocardial infarction(ami) is the most serious manifestation of coronary artery disease. ami is characterized by high mortality, high disability, and high cost. however, multicenter research on ami with large sample size in tianjin or even china is limited. by including ami in 36 hospitals,this multicenter study will capture the changes in epidemiological trends ,analyze the status of treatment in tianjin, and explore the best treatment strategies.


Eligibility criteria:
inclusion criteria: * hospitalized patients with acute myocardial infarction according to cardiac biomarker values \[selective cardiac troponin (ctc) elevation and/or decline detection, at least one value exceeds the 99% reference limit (url) and at least one of the following:（1）symptoms of myocardial ischemia；（2）new or suspected new obvious st-t changes or new left bundle branch block (lbbb)；（3）ecg pathological q waves；（4）image evidence of recent loss of viable myocardium, or new regional wall motion abnormalities；（5）coronary thrombosis confirmed by angiography or autopsy.\] exclusion criteria: * those who did not meet the diagnosis of acute myocardial infarction (no myocardial ischemia-related symptoms, elevation of markers of myocardial necrosis and imaging findings of myocardial infarction); those who met the inclusion criteria but refused to participate in the study; the researchers judged that the subjects had poor compliance and could not complete follow-up as required.

Keywords: myocardial infarction coronary disease coronary artery disease myocardial ischemia
amalgam restorations teaching in pediatric dentistry

Conditions: Dental Amalgam

Summary: to assess the pediatric dentistry educator's perception about teaching and using dental amalgam as restoration for primary teeth.

dental education has long emphasized the development of clinical skills necessary for restorative procedures. among these, amalgam restorations have been a foundational component of dental curricula for decades due to their durability, cost-effectiveness, and historical prominence in restorative dentistry. however, in recent years, the use of amalgam has become a subject of debate due to environmental concerns related to mercury content, alongside the increasing popularity of composite materials. to our knowledge no current data is available regarding teaching amalgam in pediatric dentistry in egyptian dental universities. so, the aim of this study is to assess the pediatric dentistry educator's perception about teaching and using dental amalgam as restoration for primary teeth. this could help in making improvements to the dental education system ensuring that future dentists are equipped to offer patients the best treatment options based on individual needs, improving overall oral health outcomes.

Eligibility criteria:
inclusion criteria: * participants included will be pediatric dentistry educators in egyptian universities with at least one year experience. exclusion criteria: * pediatric dentistry educators who are not willing to participate or to complete the questionnaire will be excluded also administrative and non-teaching staff

Keywords: dental education amalgam restoration
12-week placebo-controlled study of atogepant for the preventive treatment of migraine in participants with episodic migraine

Conditions: Episodic Migraine

Summary: to evaluate the safety and tolerability of atogepant 30 mg and 60 mg once a day for the prevention of migraine in participants with episodic migraine.


Eligibility criteria:
inclusion criteria: * at least a 1-year history of migraine with or without aura consistent with a diagnosis. * age of the participant at the time of migraine onset \<50 years. exclusion criteria: * has a history of migraine accompanied by diplopia or decreased level of consciousness or retinal migraine. * has a current diagnosis of chronic migraine, new persistent daily headache, trigeminal autonomic cephalgia (e.g., cluster headache), or painful cranial neuropathy. * history of an inadequate response to \>4 medications (2 of which have different mechanisms of action) prescribed for the prevention of migraine. * participants with clinically significant hematologic, endocrine, cardiovascular, pulmonary, renal, hepatic, gastrointestinal, or neurologic disease.

Keywords: migraine aura
improve-dice: study to evaluate effect of imb-1018972 on cardiac energetics in t2dm & obesity (pt 1) with hfpef (pt 2)

Conditions: Type 2 Diabetes; Diabetic Cardiomyopathies; HFpEF - Heart Failure With Preserved Ejection Fraction

Summary: the purpose of this study is to assess the activity of imb-1018972 on cardiac energetic reserve at rest and during stress and to assess safety and tolerability


Eligibility criteria:
inclusion criteria: * diagnosis of type 2 diabetes * elevated hba1c * elevated bmi * preserved left ventricular ejection fraction * diagnosis of hfpef (stage 2 only) exclusion criteria: * uncontrolled hypertension * contraindication to magnetic resonance scanning * more than mild to moderate valvular heart disease * atrial fibrillation * history of sustained ventricular tachycardia or cardiac arrest * inability to exercise (stage 2 only) * clinically significant concurrent condition which could prevent the patient from performing any of the protocol-specified assessments, represent a safety concern if the patient participates in the trial or could confound trial assessments of safety or tolerability
effects of adrenal androgens on gender-typed behavior in girls with turner syndrome

Conditions: Turner Syndrome

Summary: turner syndrome (ts) is a genetic disorder in which there is loss of all or part of the second x chromosome and occurs in 1/2500 live female births. ts is characterized by short stature and endocrine abnormalities, such as the loss of ovarian function (gonadal dysgenesis) and estrogen deficiency. the absence of pubertal development is one of the most common clinical features of patients with ts, who should have experienced a sex hormone surge if the hypothalamic-pituitary-gonadal axis was activated normally . gonadarche and adrenarche are regarded as processes that are independent of each other. the function of adrenal gland is independent of true (central/complete/gonadotropin- dependent) puberty . adrenal androgen in turner syndrome shows a wide spectrum, ranging from normal to highly elevated. x-linked genes affect the brain in at least two ways: by directly acting on the brain and by indirectly acting on the gonads to induce differences in specific gonadal secretions (i.e., hormones) that have specific effects on brain development. the changes in brain and behavioral/ cognitive phenotypes in ts individuals may be the result of a direct genetic factor, an indirect hormonal factor, or a combination of the two factors . to evaluate direct effect of x chromosome, a lot of neuroimaging studies have revealed both neuroanatomical and neurofunctional changes in patients with ts. s. c. mueller (2013) reported that oestrogen deficiency exhibits paradoxical healthy male-like patterns (i.e., a larger amygdala but reduced hippocampal volume). this finding confirms the indirect hormonal effect on the brain that are likely attributed to the effect of androgen on the brain or may be due to active role of estrogen in feminization of brain . the cognitive phenotypes of ts include severe deficits in multiple cognitive domains: visual-spatial ability, mathematical processing, and social cognition. regarding intelligence, numerous ts studies have a lower performance iq in contrast to a within-normal verbal iq in ts individuals . the presence of hypogonadism with normal or may be elevated adrenal function in girls with turner syndrome provide a model to study the hormonal effect of adrenal androgen in absence of estrogen on gender-role behavior. ehrhardt et al (1970) reported that women with ts are described as clearly feminine in their behavior and interests . to the best of our knowledge, there have been no previous studies on the correlation between level of adrenal androgen and gender-typed behavior in girls with ts.


Eligibility criteria:
inclusion criteria: * girls with turner syndrome (ts) (karyotype 45, x) younger than 18 years of age and tanner stage matched healthy control girls with normal karyotype attending outpatient clinic at sohag university hospital will be included in the study. exclusion criteria: * failure to obtain informed consent
long-term observation pms for afatinib

Conditions: Carcinoma, Non-Small-Cell Lung

Summary: in japan, post-approval execution of post marketing surveillance (pms) is requested by the japanese pharmaceutical affairs law (j-pal) in order to accumulate safety and efficacy data for reexamination. reexamination period is defined by j-pal. eight years after approval of a new substance, results of pms need to be submitted as a part of reexamination dossier to the japanese regulatory authority, the ministry of health, labour and welfare (mhlw).


Eligibility criteria:
inclusion criteria: - patients with epidermal growth factor receptor (egfr) mutation-positive inoperable or recurrent non-small cell lung cancer (nsclc)will be included. exclusion criteria: - none
artificially intelligent model for accurate detection of hcc

Conditions: Hepatocellular Carcinoma (HCC)

Summary: purpose: integrating comprehensive information on hepatocellular carcinoma (hcc) is essential to improve its early detection. the investigators aimed to develop a model with multi-modal features (mmf) using artificial intelligence (ai) approaches to enhance the performance of hcc detection. experimental design: a total of 1,092 participants were enrolled from 16 centers. these participants were allocated into the training, internal validation, and external validation cohorts. peripheral blood specimens were collected prospectively and subjected to mass cytometry analysis. clinical and radiological data were obtained from electrical medical records. various ai methods were employed to identify pertinent features and construct single-modal models with optimal performance. the xgboost algorithm was utilized to amalgamate these models, integrating multi-modal information and facilitating the development of a fusion model. model evaluation and interpretability were demonstrated using the shapley additive explanations method.


Eligibility criteria:
inclusion criteria: * benign liver diseases, including but not limited to, hemangiomas, hepatic cysts, focal nodular hyperplasia, and cirrhosis exclusion criteria: * participants who had undergone previous treatment for hcc or benign liver diseases, * had taken medications affecting the hematological system within 2 weeks * those who had received a blood transfusion within 6 months

Keywords: hepatocellular carcinoma; early detection; multi-modal; fusion model; artificial intelligence
serial third trimester abdominal circumference and amniotic fluid measurements versus routine care

Conditions: Fetal Growth Abnormality; Amniotic Fluid; Disorder

Summary: the purpose of this study us to compare the rate of prenatal identification of abnormal fetal growth or amniotic fluid between clinical evaluation of uterine size by symphysis fundal height (sfh) measurements versus point-of-care ultrasound (poc-us) evaluation of abdominal circumference (ac) and maximum vertical pocket (mvp).


Eligibility criteria:
inclusion criteria: * maternal age of 18 at the time of consent * singleton gestation * ultrasound examination that confirms or revises the estimated date of delivery (edd) before 22 0/7 weeks of gestational age * gestational age ≥ 24 weeks gestation exclusion criteria: * abnormal aneuploidy screening (1st trimester screening, 2nd trimester screening, integrated screening, nipt) * fetal chromosomal or genetic abnormalities * fetal malformations or soft markers identified on fetal anatomy survey * current pregnancy is a result of in vitro fertilization * documented uterine bleeding after 24 weeks gestation. unobserved self-reported bleeding with confirmed intact pregnancy on ultrasound after the bleeding episode is not an exclusion criterion. * uterine/placental abnormalities including uterine malformations (i.e bicornuate uterus, didelphus uterus), abnormal placentation (placenta previa, accrete, percreta), uterine fibroids. * cerclage in the current pregnancy * history of intrauterine fetal demise * fetal isoimmunization or alloimmunization * history of medical complications such as: * cancer (including melanoma but excluding other skin cancers) * endocrine disease including thyroid disease (recently diagnosed or whose medication dose is not stable), adrenal disease, diabetes mellitus (pregestational and gestational). * renal disease with altered renal function (creatinine \> 0.9 or proteinuria) * epilepsy or other seizure disorder * any collagen disease (lupus erythematosus, scleroderma, etc.) * active liver disease (acute hepatitis, chronic active hepatitis, persistently abnormal liver enzymes) * hematological disorder including alloimmune and isoimmune thrombocytopenia but excluding mild iron deficiency anemia (hb \> 9 gm/dl). patients with sickle cell disease are excluded. * chronic pulmonary disease including asthma requiring regular use of medication and active tuberculosis (tb). an asthma inhaler used on an as needed basis (prn) for a cold or an asthma attack is not considered regular use. * heart disease except mitral value prolapse not requiring medication * cardiovascular disorders: chronic hypertension * liver disorders accounting for cholestasis * infectious diseases: hiv, cytomegalovirus (cmv), toxoplasmosis, parvovirus b19

Keywords: pregnancy ultrasound neonatal morbidity
nitrate modulates cognitive impairment via oral microbiota.

Conditions: Microtia; Alcohol Dependence

Summary: alcohol use is increasingly prevalent in modern society and is known to cause cognitive impairment and dysregulation of inflammatory responses. in the present study, the investigators want to perform a randomised controlled trials to test whether nitrate could change the oral microbiota and benefit the cognitive impairment in alcohol dependence patients. the investigators survey the oral bacterial communities in saliva samples of 70 alcohol dependent patients following 14 days of dietary inorganic nitrate (nitrate-rich beetroot juice, \~750 mg no3- /d) and placebo (nitrate-depleted beetroot juice, \~1 mg no3- /d) supplementation.


Eligibility criteria:
inclusion criteria: 1. han nationality 2. montreal cognitive assessment(moca) score \>11 3. diagnosis of alcohol dependence exclusion criteria: 1. past or current infectious disease 2. past or current heart, brain, liver, kidney, and other severe diseases 3. past or current metabolic diseases that can lead to abnormalities of the immune system, such as obesity (body mass index \> 30 kg/m2), diabetes, or rheumatoid arthritis 4. past or current neurodegenerative diseases, such as parkinson's disease 5. use of steroidal and non-steroidal anti-inflammatory drugs, antibiotics, antioxidants, and immunosuppressive agents within two months of enrollment 6. use of probiotics and probiotics every day for the first two months before enrollment 7. previous or current dsm-iv diagnosis of schizophrenia, depression, anxiety disorder, bipolar disorder, mental retardation, dementia (excluding mild cognitive impairment, mci), or substance dependence other than alcohol and nicotine 8. irregular eating habits that affect the oral flora (except alcohol) in the previous two months 9. current oral disease

Keywords: nitrate oral microbiota alcohol dependence
first-in-human study of ot-a201 in patients with selected hematological malignancies and solid tumors

Conditions: Hematological Malignancy; Solid Tumor

Summary: this phase 1 study is aimed at establishing the safety basis of ot-a201 in the treatment of hematological malignancies and solid tumors. in the dose of escalation part it is to characterize the overall safety and tolerability profile and determine the recommended dose(s) of ot-a201 as monotherapy, and in various combination regimens. preliminary information about anti-cancer activity will be further explored in the expansion part of the study.


Eligibility criteria:
main inclusion criteria: * histologically or cytologically confirmed relapsed/refractory hematological malignancy or advanced/metastatic solid cancer * measurable disease * have had all available therapeutic standards for their disease * willingness to undergo baseline biopsy/bone marrow aspiration in case biopsy was not collected after completion of the most recent prior therapy * ecog performance status ≤ 1 * life expectancy \> 3 months as assessed by the investigator * acceptable clinical lab results main exclusion criteria: * systemic steroids at a daily dose of \> 10 mg of prednisone or equivalent within 28 days before study treatment. transient use of steroids for other medical condition may be allowed * ongoing immune-related adverse events iraes and or aes ≥ grade 2 from previous therapies not resolved except vitiligo, stable neuropathy up to grade 2, hair loss, and stable endocrinopathies with substitutive hormone therapy * within 4 weeks of major surgery * documented history of active autoimmune disorder requiring systemic immunosuppressive therapy within the last 12 months * prior solid organ transplant * primary or secondary immune deficiency * active and uncontrolled infection requiring intravenous antibiotic or antiviral treatment * seropositive (except after vaccination or confirmed cure for hepatitis) for human immunodeficiency virus (hiv), hepatitis b virus (hbv), or hepatitis c virus (hcv) * clinically significant disease
intramuscular ketamine effect on postnasal surgery agitation

Conditions: Agitation, Emergence

Summary: emergence agitation (ea) is a common complication after nasal surgery. in this study, we aimed to investigate the effect of intramuscular ketamine on ea following septoplasty and open septorhinoplasty (osrp) when administered at subanesthetic doses at the end of surgery. sedation and agitation scores were recorded using the richmond agitation-sedation score after extubation.

at the end of surgery and immediately after the inhalational agent was discontinued, 2ml of normal saline containing 0.7 mg/kg racemic ketamine was administered intramuscularly to group-k, whereas 2 ml of normal saline was administered intramuscularly to group-s using a 3 ml syringe. the injection site of both groups was at the lateral thigh. for postoperative analgesia, 0.07 mg/kg morphine was also given when turning off the inhalational agent. a nasal pack was used in all of the patients. the patients were ventilated with 100% oxygen at a flow rate of 7 l/min. once the patients met the extubation criteria, they were extubated. the ea level of the patients was evaluated immediately after extubation till the patient was handed over to the pacu using richmond agitation-sedation scale (rass), table 1, and the highest score was documented by the main investigators. in this study patients with a rass score of +2 or more were considered to have ea.

Eligibility criteria:
inclusion criteria: 1. age group 18-64 years old 2. asa i-ii 3. bmi 20-29.9 4. patients accepting the study and consenting 5. undergoing general anesthesia for scheduled septoplasty or open septorhinoplasty. exclusion criteria: 1. ketamine allergy 2. morphine allergy 3. history of cardiac, neurological, or psychiatric disease, glaucoma, 4. patients with a body mass index of less than 20 or more than 30 kg/m2

Keywords: agitation emergence ketamine intramuscular nasal surgery
a pk and salvage study for children with hiv-infection

Conditions: HIV Infections

Summary: to evaluate the pharmacokinetics (pk) of lpv/r with saquinavir in hiv-1 infected children. to evaluate treatment response (clinical, immunological and virological) to lpv/r, sqv in thai children.

the pk and 24 week data has been published in pediatric infectious diseases journal. it showed that plasma drug concentrations of saquinavir, lopinavir and ritonavir were at the higher limits of expected ranges for adult treatment at approved dosages (1000/100 mg bid for saquinavir, 400/100 mg bid for lopinavir/r). the regimen was well tolerated and showed significant cd4 rise and vl decline at 48 weeks.

Eligibility criteria:
inclusion criteria: 1. confirmed hiv-1 infection by hiv-dna pcr if \< 18 months old or by hiv elisa if greater than or equal to 18 months old 2. subject is less than or equal to 16 years of age at the day of the first dosing. 3. subject is failing a current nrti and/or nnrti containing regimen and is naïve to protease inhibitor containing therapy. 4. results of biochemistry and haematology testing should be within pre-specified ranges. 5. subject is able to swallow capsules 6. caretaker(s) is/are able and willing to sign the informed consent form prior to screening evaluations. exclusion criteria: 1. history of sensitivity/idiosyncrasy to lopinavir, ritonavir, saquinavir or chemically related compounds or excipients which may be employed in the trial. 2. relevant history or current condition that might interfere with drug absorption, distribution, metabolism or excretion. 3. inability of both child and caregiver(s) to understand the nature and extent of the trial and the procedures required. 4. use of any of concomitant medication, including the drug listed below, that may interfere with the pharmacokinetics of lpv/r or sqv. * nnrtis * rifampicin * rifabutin * phenobarbital * phenytoine * carbamazepine * dexamethasone * ketoconazole * clarithromycin 5. pregnancy

Keywords: lopinavir/r saquinavir dual boosted pis pharmacokinetics hiv children c min second line haart arv vl failure dosage to evaluate treatment response treatment experienced
effects of probiotic supplementation in hypertensive women on menopause

Conditions: Systemic Arterial Hypertension; Menopause; Dysbiosis; Autonomic Nervous System Imbalance

Summary: in postmenopausal women, cardiovascular risk is increased and the mechanisms involving imbalance of the autonomic nervous system should be extensively investigated. recent data suggest a link with intestinal microbiota dysbiosis and probiotic supplementation could be a useful strategy for treating women with increased cardiovascular risk.

after randomization, subjects will be included in their intervention group for a period of three months with initial and final evaluations. the study will evaluate the effects and possible benefits of probiotic supplementation on the functioning of the autonomic nervous system and vascular changes in hypertension in menopausal women. the intervention groups will be as follows: 1. - menopausal women with hypertension + probiotic supplementation 2. - menopausal women with hypertension + placebo supplementation

Eligibility criteria:
inclusion criteria: * hypertensive * at least 1 year of menopause * sedentary exclusion criteria: * smoker * use of psychiatric medications * cardiovascular events * recent surgeries * diabetic * use of beta blockers
febrile illness in guinea

Conditions: Febrile Illness

Summary: to date, the underlying causes of community-acquired fever, particularly non-malarial fever, are insufficiently documented in guinea. moreover, diagnostic capacity is limited, leading to inadequate prescription of antibiotics and antimalarials, as well as substantial delay in outbreak recognition. thus, the investigators undertook a prospective observational multi-centric cohort study of febrile patients presenting at the emergency and outpatient department of selected health centers, districts and regional hospitals in four ecologically distinct sentinel health districts in guinea.


Eligibility criteria:
inclusion criteria: * age ≥2 months old * documented fever (axillary temperature \>37.5°c) at presentation or fever reported within the prior 24 hours * availability for follow-up for 21 days * willingness and ability of the patient or culturally acceptable representative to give informed consent for participation in the study exclusion criteria: * history of hospitalization (for \> 48 hours within the last 14 days) at any health facility