Kornimate/medical-research-clean huggingface dataset:
health of pessary versus progesterone supplement for preventing preterm birth children

Conditions: Preterm Birth

Summary: to give strong recommendations on the efficacy and safety of vaginal progesterone versus cervical cerclage, we conduct this study to investigate the physical and mental development of children from vaginal progesterone versus cervical cerclage. based on our research (dang et al., 2019), the twin pregnancies with cervical lengths less than 38mm were randomly assigned to receive vaginal progesterone or cervical cerclage, which leads to the similarity in characteristics of these two groups. hence, the result of analyzing these offsprings would be preciously valuable.

preterm birth (pb) is the leading cause of neonatal morbidity and mortality. twin pregnancies and short cervical length are two high-risk factors of pb. generally, in singleton pregnancies with short cervical length below 25 mm, or with a history of preterm birth, preventive measures of pb are vaginal progesterone and cervical cerclage. the cervical pessary is also being investigated for effectiveness in pb prevention in different populations. however, the effective preventive methods for pb has not been identified up to now in twin pregnancies with short cervical length. in our research, the results showed that the preterm birth rate before 34 weeks in the cervical pessary group was lower than the progesterone group (16% vs 22%, rr 0.73; 95% ci 0.46 - 1.18). the perinatal outcomes were also better in the cervical pessary group than in the progesterone group (19% vs 27%, rr 0.70; 95% ci 0.43 - 0.93). the cost of the cervical pessary method was also significantly lower than the vaginal progesterone method cost. pessary insertion was also more convenient since it was only inserted once during pregnancy, compared to daily vaginal progesterone. therefore, the cervical pessary may be an appropriate option for preventing preterm birth in twin pregnancies with a short cervix. however, besides these short-term outcomes, we need to pay more attention to the longer-term issues of both mothers and infants. some evidence up to now has demonstrated that both these two methods are safe with no impact on physical, mental, and motor development of children up to 3 years old and even in older children. however, such evidence is still rare. also, there hasn't been any study evaluating the impact, if any, of these two pb preventive methods.

Eligibility criteria:
inclusion criteria: * live babies born from the pessary versus vaginal progesterone in women with a twin pregnancy and a cervix \<38 mm study (nct02623881) * parents agree to participate in the study. exclusion criteria: * babies died after the perinatal period.

Keywords: pesary progesterone asq-3 health of children
long-term safety of uc-msc transplantation in patients with retinitis pigmentosa

Conditions: Retinitis Pigmentosa

Summary: the study will perform to follow-up uc-mscs and cm transplantation. 18 patients will be called back to be examined after 5 years of uc-msc and/or cm transplantation.

the study will be performed on 18 patients who received uc-msc and cm transplantation in 2018. the study is included as retrospective cohort since the transplantation happened 5 years ago. patients will do a visual field test, visual acuity test, electroretinography, funduscopy, and optical coherence tomography examination. the observation results will be written in the observation table and analyzed by a statistic.the study will be performed at rumah sakit jakarta eye center and rumah sakit umum pusat dr. sardjito yogyakarta.

Eligibility criteria:
inclusion criteria: * visual field defects at the initial examination with humphrey perimetry are between 25% to 50% * willing to sign informed consent as research subjects * willing to do the peribulbar injection with mesenchymal stem cells isolated from umbilical cord tissue * willing to do visual field checks with humphrey's perimetry, vision tests with snellen boards, optical coherent tomography (oct) examinations, electroretinogram examinations and fill out a quality of life questionnaire exclusion criteria: * pregnant or nursing women * positive result of hiv test * have a history of eye tumours * in the immunosuppressive treatment or other drugs that can affect the growth of transplanted stem cells * have another eye disease such as diabetic retinopathy, uveitis, cataract, and glaucoma * do not come to control according to the schedule determined by the researcher (loss to follow up)

Keywords: allogeneic mesenchymal stem cell umbilical cord mesenchymal stem cell conditioned medium allogeneic umbilical cord mesenchymal stem cell safety
myocardial infarction with non-obstructive coronary arteries in turkish population

Conditions: Acute Coronary Syndrome; Myocardial Infarction; Atrial Fibrillation; Diabetes Mellitus

Summary: the objective of this study is to analyze the demographics, clinical profiles, management, in-hospital and long-term outcomes of patients with acute coronary syndrome syndrome and myocardial infarction with non-obstructive coronary artery disease.

acute coronary syndrome is leading causes of death worldwide. although, \>90% of these patients had of culprit coronary lesion, a significant proportion of them had no any angiographic evidence of obstructive coronary arteries. exact mechanism of the myocardial infarction remains unclear of these patients. however, mi registries have reported that the 5% to %10 of mi patients have no evidence of obstructive coronary artery disease. there is lack of any data regarding prevalence, demographics, patients' profile, management, and outcome of this clinical entity in turkish population. this registry aims to obtain these data in myocardial infarction with non-obstructive coronary artery disease patients in turkish population. although there are huge data in this issue from different country and geographic areas, to date no any national data about prevalence, demographics, management and in-hospital outcomes of af patients who admitting with cute coronary syndrome. with this rationale the registry also aims to obtain demographics, clinical profile, management, and in-hospital outcome of af in turkish acute coronary syndrome population.

Eligibility criteria:
inclusion criteria: 1. patients older than 18 years 2. evidence of an mi as defined any one of the following criteria: detection of a rise and/or fall of cardiac biomarker values \[preferably cardiac troponin (ctn)\] with at least one value above the 99th percentile upper reference limit (url) and with at least one of the following: i. symptoms of ischaemia. ii. new or presumed new signiﬁcant st-segment-t wave (st-t) changes or new left bundle branch block (lbbb). iii. development of pathological q waves in the ecg. iv. imaging evidence of new loss of viable myocardium or new regional wall motion abnormality. v. identiﬁcation of an intracoronary thrombus by angiography. 3. invasive diagnostic coronary angiography (idca) findings to allow determination of the presence /absence of obstructive coronary artery disease 4. signed informed consent form to trial participation exclusion criteria: 1. inability/refused to provide informed consent 2. age below 18 years 3. patients with unstable angina pectoris (acs without increase and/or decrease of a cardiac biomarker, preferably high-sensitivity cardiac troponin, with at least one value above the 99th percentile of the upper reference limit) 4. patients refused invasive diagnostic coronary angiography 5. myocardial infarction associated with revascularization procedures

Keywords: acute coronary syndrome minoca myocardial infarction atrial fibrillation
multicentric, open label with retrospective inclusion and follow-up of acetabular prothetic implant "polymax"

Conditions: Osteoarthritis

Summary: total replacement of hip joint is one of the most important medical innovations of the twentieth century. more than 100,000 hip replacements are being laid each year in france. improved fixation, reduced wear rates and reduced implant dislocation rates remain subjects of continuous improvement. hip implants cemented and cementless are part of therapeutic arsenal of orthopedic surgeons for joint replacement of the defective hip. the anchor and friction torque are both essential to the survival of hip implants. therefore acetabular implants without cement with ceramic insert or polyethylene in a metalback or full polyethylene coated with titanium grains without metalback are proposed, but they have their own complications (squeaking, fractures, recovery difficulties, difficult radiographic analysis, high cost for ceramics, primary stability defects, instability of the instrument set, titanium residues in absence of metalback. an alternative to these implants may be an acetabular component without cement with polyethylene insert with an end metalback to increase both polyethylene thickness and size of the head in order to expect a low complication rate with important longevity for a lower cost. this study was conducted to ensure the safety and effectiveness of the acetabular implant "polymax"


Eligibility criteria:
inclusion criteria: * patient suffering from hip disease: primary or secondary hip osteoarthritis or osteonecrosis. * patient having been implanted with a polymax implant; * patient having agreed to participate in a follow-up 5 years; * patient who have accepted the use of their data in the context of this study. * patient having pre-operative and post-operative data exclusion criteria: * pre or post-operative partial data * patients not available for follow up at 2 and 5 years .. * metabolic disease or autoimmune witch may interfere with bone growth not allowing the indication of a prosthesis without cement, * mental disorder or disease of proven behavior. * severe osteoporosis, * direct or indirect bone irradiation

Keywords: acetabular implant
dorsal penile nerve block for rigid cystoscopy in men

Conditions: Pain

Summary: this study will determine the effectiveness and safety of dorsal penile nerve block (dpnb) in men undergoing rigid cystoscopy.

pain is common in men undergoing rigid cystoscopy. even with application of a lubricant containing 2% lidocaine, about 76% men suffer from mild to severe pain when undergoing rigid cystoscopy, and approximately 27% men could still feel mild to moderate pain 7 days after the procedure. the most painful part of the procedure for men is when the cystoscope passes through the membranous urethra. song et al did autopsy on males found dorsal nerve of the penis (dnp), the terminal branch of the pudendal nerve, innervates the membranous urethra in 53.3% specimens. in addition, urethral mucosa has branches of dnp innervated. dorsal penile nerve block (dpnb) is usually used for circumcision in children and it has been shown to provide effective analgesia for penile surgeries. according to the evidence that some dnp branches innervate membranous urethra and urethra mucosa and most pain originates from cystoscope passing through membranous urethra, we speculated that dpnb could overall reduce pain level in men during rigid cystoscopy.

Eligibility criteria:
inclusion criteria: * american society of anesthesiologists (asa) physical status i-ii * without history of urethral or prostatic surgery * without respiration or circulation disorders * without chronic pain exclusion criteria: * allergy to local anesthetics * coagulation disorder or usage of antiplatelet drugs * infection at the site of puncture point * severe urethral stenosis

Keywords: analgesia cystoscopy dorsal nerve of penis nerve block ropivacaine
effect of all-stim 2 quadriceps treatments on limb muscle strength in mechanically ventilated patients

Conditions: Weakness

Summary: patients that are on mechanical ventilators in medical intensive care units (micu) have extremely weak leg muscles. currently there is no treatment to prevent or reverse this weakness. treatments with a thigh muscle stimulator, called an all stim 2, can improve leg muscle strength and help patients regain leg function after knee surgery. the purpose of the present study is to determine if treatments with the all stim 2 device can also improve leg muscle strength in patients on mechanical ventilation.

the objective for this study is to determine if daily exercise using all-stim 2 stimulation of quadriceps muscles will increase leg strength and improve outcomes (duration of hospitalization, long term mobility, long term disability) for mechanically ventilated micu patients. the investigators plan to randomize patients accepted into this protocol to administration of either sham exercise (i.e. placement of all-stim 2 units on the legs for 30 minutes a day without activation of the electrical stimulation program) or active exercise (placement of all-stim 2 electrodes on both legs and stimulating quadriceps muscles to rhythmically contract for 30 minutes a day). the two groups (sham and active exercise) will be treated for 30 minutes a day for seven days. the effects of exercise on quadriceps strength will be assessed by measuring quadriceps force generation (quadtw) in response to magnetic stimulation of the femoral nerves. the quadtw assessment will be made immediately before institution of sham or active exercise and will repeated one day after the conclusion of the seven day training regimen. chart review and patient follow-up will be used to determine if this treatment regimen also has an impact on clinical outcome measures, i.e. duration of hospitalization.

Eligibility criteria:
inclusion criteria: * adult patients requiring mechanical ventilation for more than 48 hours * respiratory failure present exclusion criteria: * the physician caring for the patient determines that the patient is too unstable * use of high dose pressors (more than 15 mcg/min of norepinephrine or more than 15 mg/kg/min of dopamine) * use of more than 80% fio2 (fractional concentration of oxygen) or more than 15 cm h2o (water) of peep (positive end expiratory pressure) * presence of a cardiac pacemaker or implanted defibrillator * use of neuromuscular blocking agents within the 48 hours preceding testing * history of a preexisting neuromuscular disease * presence of profound and uncorrectable hypokalemia (less than 2.5) or hypophosphatemia (less than 1.0) * pregnancy * if the patient is a prisoner * if the patient is institutionalized * if it is thought that the patient will have care withdrawn within 7 days
phase 1 study of intravitreal autologous cd34+ stem cell therapy for retinitis pigmentosa

Conditions: Retinitis Pigmentosa

Summary: in this phase 1 open-labeled prospective study, one eye of each participant with vision loss from retinitis pigmentosa will be administered intravitreal injection of autologous cd34+ stem cells harvested from bone marrow. each participant will be examined serially for 6 months after study injection to determine safety and feasibility of this intervention.


Eligibility criteria:
inclusion criteria: 1. age \>18 years of age 2. visual acuity at presentation of 20/100 to counting fingers or constriction of peripheral visual field 360 degrees to \ 3 months 3. vision loss due to retinitis pigmentosa 4. the study eye has the worse visual acuity or peripheral constriction. 14. able and willing to sign consent 15. able to keep follow-up appointments for at least 6 months exclusion criteria: 1. other concurrent optic nerve or retinal disease in study eye affecting vision 2. history of active retinal or choroidal neovascularization or macular edema in study eye requiring on-going intravitreal or periocular therapy in study eye 3. active eye or systemic infection 4. significant media opacity in the study eye precluding view of the fundus for examination, photography or optical coherence tomography (oct) 9. other cause for vision loss in the study eye 10. history of coagulopathy or other hematologic abnormality 11. use of coumadin within 3 days of enrollment 12. concurrent immunosuppressive therapy 13. history of allergy to fluorescein dye

Keywords: retinitis pigmentosa stem cell retinal degeneration intravitreal
be sweet to babies during nasolaryngoscopy

Conditions: Infant Conditions

Summary: the investigators want to know if sugar water containing 24% sucrose is helpful in reducing pain in babies during scopes.

this study aims to evaluate the impact of oral sucrose on pain or distress in outpatient infants undergoing flexible nasolaryngoscopy during a scheduled appointment at the sickkids pediatric otolaryngology clinic.

Eligibility criteria:
inclusion criteria: * patient \<12 months of age; * scheduled for an appointment with dr. nikolaus wolter or dr. jennifer siu, who are staff pediatric otolaryngologists at the hospital for sick children, or meghan tepsich, a complex airway nurse practitioner at sickkids; * requiring flexible nasolaryngoscopy for diagnostic purposes; * accompanied by caregivers who provided consent. exclusion criteria: * patient \>12 months of age * infants \<37 weeks corrected gestational age * infants with decreased level of consciousness or delayed neuromuscular development with limited pain response * infants who have received acute/urgent /emergent airway assessment such as respiratory distress or a foreign body, etc. * infants who have received topical anesthesia (topical decongestant/anesthetic spray) * infants with the following conditions, where oral sucrose is contraindicated or ineffective: * carbohydrate intolerance * decreased level of consciousness or heavy sedation * absent gag reflex * non-functional gastrointestinal tract * history of aspiration, tracheoesophageal fistula * necrotizing enterocolitis * infants whose parents did not consent to enrolling their child in the study, including randomization into either arm of the study due to preference for a given intervention * any other circumstance in which consent for participation in the study was not obtained prior to the scope infants will also be excluded from the study if they present with conditions in which fnl is contraindicated: * severe respiratory distress * post-palliative systemic artery to pulmonary artery shunt * single ventricle congenital heart disease
detection of dengue virus in plasma of patients in nepal

Conditions: Dengue Fever

Summary: to test whether karius infectious disease diagnostic sequencing assay can detect dengue virus in plasma from suspected cases of dengue or dengue fever like-illnesses from samples collected as part of a hospital-based multi-site study conducted in nepal.

blood samples will be obtained from consented subjects as part of a hospital-based multi-site study conducted in nepal and will be shipped to karius, redwood city, ca. the investigators will test whether the karius test can detect dengue virus in plasma from those suspected cases and measure the performance of the karius test against standard tests (pcr, elisa test and neutralization assays) used to determine a final diagnosis of dengue fever.

Eligibility criteria:
inclusion criteria: * 18 years and older, suspected of having dengue or dengue fever-like illnesses. exclusion criteria: * inability to understand instructions and comply with study-related procedures, inability to understand and/or sign informed consent, any condition that will prevent the subject from completing the study.

Keywords: ngs sequencing
the effect of assisted reproductive technology on male sexual function.

Conditions: Erectile Dysfunction

Summary: men participating in assisted reproductive technology treatments will be recruited to a study involving filling erectile function questionnaires throughout fertility treatments, pregnancy and up to 1 year after birth.

men participating in fertility will be recruited to a study involving filling erectile function questionnaires throughout fertility treatments, pregnancy and up to 1 year after birth. in addition, participants will be questioned regarding marital life, sexual intercourse frequency, medical history and treatments for erectile dysfunction in relevant cases. thes control group will be comprised of male subjects who did not require fertility treatments to conceive.

Eligibility criteria:
inclusion criteria: * participation in fertility treatments. exclusion criteria: * none.
genetic- and biological-markers of predisposition to atherosclerosis: leipzig-heart study

Conditions: Atherosclerosis; Coronary Arteriosclerosis; Carotid Artery Diseases; Genetic Predisposition to Disease; Biological Markers

Summary: atherosclerotic cardiovascular disease is the major cause of morbidity and mortality in western societies. it is a complex genetic disorder with many genes involved and significant gene-environment interactions. the aim of the study is to identify novel genetic- and biological-markers of atherosclerosis. atherosclerosis is assessed in the coronary arteries using coronary angiography as well as in the carotid artery (intima-media-thickness) and peripheral vessels (ankle brachial index). association analysis of genetic and metabolic markers with atherosclerotic burden will be performed to identify novel factors of disposition to atherosclerotic vascular disease.


Eligibility criteria:
inclusion criteria: * patients assigned to coronary angiography exclusion criteria: * cancer * acute myocardial infarction * inability to give informed consent
monotherapy with levetiracetam or carbamazepine in patients suffering from epilepsy.

Conditions: Epilepsy, Tonic-clonic

Summary: a double-blind follow-up trial assessing the long term safety of levetiracetam as per adverse events reporting, physical and neurological examination and vital signs


Eligibility criteria:
inclusion criteria: * subjects with a confirmed diagnosis of epilepsy. * subjects having experienced in the past unprovoked partial seizures (ia, ib, ic with clear focal origin), or generalized tonic-clonic seizures (without clear focal origin), that are classifiable according to the international classification of epileptic seizures * subjects coming from the n01061 monotherapy trial and for whom double-blind continuation of investigational product is beneficial. exclusion criteria: * need for an additional aed.

Keywords: monotherapy, epilepsy levetiracetam keppra