Kornimate/medical-research-clean huggingface dataset:
assessment of the cytotoxic immune status of pancreatic cancer patients and the severity of the cancer using measurement of natural killer cell activities

Conditions: Pancreatic Cancer

Summary: pancreatic cancer is the 5th leading cause of cancer death and the worst prognostic cancer in the world. this is due to high recurrent rate after surgical resection and poor response to chemotherapy and radiotherapy. recent studies revealed that peri-tumoral structure and patients' immune status including cytotoxic immunity played significant role in the bad behavior of pancreatic cancer. while past studies focused on oncogenes and tumor suppressor genes, recent studies focused on patients' own immunity. patients' immunity modified by cancer cells is found to be correlated to cancer progression and metastasis. natural killer cells, playing an important role in cytotoxic immune system, are revealed to be decreased in patients with lung cancer, ovarian cancer, prostate cancer, colorectal cancer, and breast cancer. and in melanoma mouse model, when nk cell was suppressed, cancer progression and metastasis were accelerated. this study sought to find the correlation of patients' cytotoxic immune status to cancer progression and status by measurement of nk cell activity in pancreatic cancer patients. this would be basic support to construct a prognostic model of pancreatic cancer for early metastasis and post operational recurrence.


Eligibility criteria:
inclusion criteria: * age over 18 and under 85 * control group : incidental found benign pancreatic cyst, non-neoplastic gall bladder polyp (ex, cholesterol polyp), healthy people having no evidence of malignancy in check up within 1 year * patient group : histological diagnosed pancreatic cancer patients, clinically diagnosed pancreatic cancer patients by radiologic evaluation * agreed to enroll the study and signed informed consent exclusion criteria: * patients with other malignancies within 5 years * patients treated with steroid due to any reason within 1 year * not signed informed consent
potential benefits of sleeve gastrectomy surgery on diabetic gastroparesis symptoms

Conditions: Weight Loss; Diabetic Gastroparesis; Bariatric Surgery Candidate; Sleeve Gastrectomy; Gastric Emptying

Summary: the purpose of this registry is to evaluate if sleeve gastrectomy surgery will help with symptoms of delayed gastric emptying for patients suffering from diabetic gastroparesis.

this is a prospective registry enrolling patients with an established diagnosis of diabetic gastroparesis and interested in receiving a sleeve gastrectomy for weight loss. an often intentional outcome of sleeve gastrectomy is an increase in gastric emptying. the relationship between how beneficial this outcome could be for diabetic gastroparesis patients suffering from delayed gastric emptying is not very well established. the purpose of this study is to find out if sleeve gastrectomy surgery will also help with symptoms of delayed gastric emptying. this study involves completing the gastroparesis cardinal symptom index questionnaire before your weight loss surgery and after surgery at the following time points; 30 days, 3 months, 6 months, and 12 months.

Eligibility criteria:
inclusion criteria: * age 18 years and above * bmi \> 35 * diagnosis of diabetic gastroparesis as confirmed via scintigraphy * subject opting to undergo sleeve gastrectomy exclusion criteria: - any previous weight loss surgery or prior gastrectomies

Keywords: sleeve gastrectomy gastric emptying diabetic gastroparesis bariatric surgery candidate
comparison of a hyperinflation mode and air stacking on neuromuscular patients under volumetric ventilation

Conditions: Neuromuscular Disease

Summary: the purpose of the study is to compare the the efficacy and tolerance of 2 cough assistance techniques requiring no equipment other than the volumetric fan. the two methods are air-stacking and hyperinflation . the study is a cross-over, monocentric and open label study

primary outcome : peak expiratory flow (pef)

Eligibility criteria:
inclusion criteria: * age\>18 years, neuromuscular disease, * restrictive syndrome and/or cough peak flow \< 270.l/mn and/or maximal expiratory pressure \< 40 cm ho2, * patient under non invasive ventilation * steady state for at least one month * written consent form given exclusion criteria: * bronchial congestion * hemodynamic instability * previous pneumothorax or emphysema bubbles * major bulbar dysfunction * plan of legal protection * pregnant or breastfeeding women * no affiliation to a social security scheme

Keywords: cough help mechanical insufflation mechanical ventilation neuromuscular diseases peak cough flow
protein-rich diet and nafld in bariatric surgery

Conditions: Obesity; Non-alcoholic Fatty Liver Disease

Summary: randomized, single-blind, trial to determine whether a high-protein, low calorie diet is more effective than a control low calorie diet in improving the metabolic and histologic abnormalities in patients with non-alcoholic fatty liver disease undergoing bariatric surgery.


Eligibility criteria:
inclusion criteria: * morbidly obese subjects with a bmi \>40 kg/m2 who are eligible for bariatric surgery and have accepted to undergo rygb * weight stable for at least 6 months before the study (+/- 5 kg within the previous 6 months) * stable medication * provision of informed consent exclusion criteria: * patients not eligible for laparoscopic rygb * incapacity to give a valid informed consent or unwilling to give the consent * pregnancy or lactating * type 2-diabetes mellitus * significant illness within the two weeks preceding surgery, as judged by the physician. * obvious infection (bacteria, virus etc) * major cardiovascular disease * major gastrointestinal, respiratory, or any hormonal disorders * history of drug addiction and/or alcohol use * suspected or confirmed poor compliance * alcohol consumption of \> 20 g per day in the case of women and \> 30 g per day in the case of men for at least 3 consecutive months during the previous 5 years * presence of hepatitis c or frank cirrhosis.
a mobile health exercise intervention for older patients with myeloid neoplasms

Conditions: Intervention

Summary: this is a pilot study to evaluate the feasibility of a mobile health exercise intervention (go-excap mobile app) over 7 weeks in 25 patients with myeloid neoplasms receiving hypomethylating agents.

up to 98% of older patients with myeloid neoplasms experience physical function decline, fatigue, and mood disturbances. mobile health exercise interventions are promising strategy to prevent physical function decline and improve fatigue and mood disturbances, but older patients with myeloid neoplasms receiving hypomethylating agents are understudied. the proposed study will evaluate a novel mobile health exercise intervention that is adapted to older patients with myeloid neoplasms receiving outpatient hypomethylating agents and investigate whether and how exercise can prevent physical function decline, improve fatigue and mood disturbances, and prevent worsening quality of life.

Eligibility criteria:
inclusion criteria: * age is greater than or equal to 60 years * have a diagnosis of mn * receiving outpatient chemotherapy (e.g., hma) * english speaking * eastern cooperative oncology group (ecog) performance status of 0-2 * no medical contraindications for exercise per oncologist * able to walk 4 meters as part of short physical performance battery measured walk (with or without assistive device) * able to provide informed consent exclusion criteria platelet count of 10,000 per microliter or less in the most recent blood draw (due to risk of spontaneous bleeding) prior to transfusion (i.e., patients are allowed to enroll if their platelet count is 10,000 per microliter or less but is scheduled to receive transfusion the day of consent)
holep vs bprp of a large volume bph: a randomised controlled trial

Conditions: BPH With Urinary Obstruction; Male

Summary: to compare bipolar resection versus holmium laser enucleation for management of large bph.

to compare safety and efficacy of bipolar resection (bprp) versus holmium laser enucleation (holep) for management of large bph (\> 75 gm).

Eligibility criteria:
inclusion criteria: * patients suffering from luts secondary to infravesical obstruction from bph * failed medical treatment * international prostate symptom score (ipss) \> 13 * a peak urinary flow rate (qmax) \< 15 ml/sec * a prostate size ≥ 75 gm exclusion criteria: * presence of a urethral stricture * neurological disorder * bladder cancer * prostate cancer * previous history of bladder neck surgery or turp

Keywords: bph enucleation large prostate luts ipss quality of life
chuspan scs bp treatment of churg-strauss syndrome without poor-prognosis factors

Conditions: Churg-Strauss Syndrome

Summary: to assess the efficacy of systemic corticosteroids alone as first-line treatment of churg-strauss syndrome without poor-prognosis factors as defined by the five-factor score (ffs=0), and to compare the efficacy and safety of azathioprine vs pulse cyclophosphamide as adjunctive immunosuppressive therapy to treat failure or relapse

all patients initially treated with systemic corticosteroids alone: optional iv methylprednisolone pulse (15 mg/kg) at treatment start followed by oral prednisone (1 mg/kg/day) according to a tapering schedule. treating physicians allowed to treat minor relapses with corticosteroids without referring the patient for randomization, as long as the prednisone dose did not exceed 0.5 mg/kg for 1 month. patients in whom prednisone doses could not be tapered below 20 mg, those who failed to enter remission and those who relapsed were randomized to receive either 6 months of oral azathioprine (2mg/kg/day) or 6 cyclophosphamide pulses (0.6g/m2 d1, d15, d30 then every month)

Eligibility criteria:
inclusion criteria: * men and women with newly diagnosed churg-strauss syndrome; * absence of poor prognostic factors as defined by the five-factor score (serum creatinine \> 140 μmol/l or 1.58 mg/dl, proteinuria \> 1 g/day, severe gastrointestinal tract involvement, specific cardiomyopathy and/or central nervous system involvement; * written informed consent. exclusion criteria: * age \< 15 years, previously treated churg-strauss syndrome; * history of cancer; * pregnant or breast-feeding women; * psychiatric disorders that might compromise compliance with therapy; * contraindication to study drug; * other ongoing therapeutic trial; * concomitant viral hepatitis b or c or human immunodeficiency virus (hiv) infection

Keywords: churg-strauss vasculitis therapy cyclophosphamide azathioprine
safety and efficacy of solithromycin in the treatment of nonalcoholic steatohepatitis without cirrhosis

Conditions: Nonalcoholic Steatohepatitis

Summary: the purpose of this study is to evaluate the effects of solithromycin on hepatic histology and biomarkers in patients with nonalcoholic steatohepatitis.

patients will be administered solithromycin for 13 weeks with regular safety visits and liver biopsies at baseline and after treatment.

Eligibility criteria:
inclusion criteria: * histologic evidence of nash based on liver biopsy obtained within 180 days * nas\> or = 5 * able to swallow capsules intact exclusion criteria: * symptoms of acute liver disease * cirrhosis on liver biopsy * positive hiv or hepatitis tests * primary biliary cirrhosis * poorly controlled diabetes with hga1c \>8.5% * alt \>4-fold upper limit of normal * qtcf \>450 msec * crcl \<40 ml/min

Keywords: nash liver disease
promoting comprehensive cervical cancer prevention and better women health in cameroon

Conditions: Cervical Cancer

Summary: in sub-saharan africa, cervical cancer is the leading cause of cancer death among women because of the difficulty in implementing screening programs. the main obstacles in these countries are poverty, lack of healthcare infrastructures and trained practitioners. with the availability of new technologies, researchers are looking for new strategies adapted to low- and middle-income countries to identify cervical precancerous lesions. current evidence shows that human papilloma virus (hpv) testing is more effective than cytology (pap smear) for cervical cancer screening in resource-limited settings. indeed, the genexpert® hpv test offers the opportunity to prevent cervical cancer (cc) in a single visit: rapid detection of high-risk hpv (hpv) infection followed by same day treatment of hpv-positive women during the same visit (screen-and-treat approach). however only a small proportion of hpv-positive women will develop cervical (pre)cancer, making it important to select those to treat. this triage can be achieved by colposcopy, cytology and visual inspection after application of acetic acid (via). though via is the triage test recommended by who for resource-limited countries, it has not yet been widely assessed in sub-saharan africa (ssa). the main objective of the investigators is to assess the performance of hpv-test followed by visual inspection after application of acetic acid and lugol's iodine via/vili to detect cervical precancerous lesions in a screen-and-treat strategy in cameroon (sub-saharan africa) where there is no cervical cancer-screening program. the investigators organized a successful free screening campaign in cameroon in 2015 that allowed to identify the expectations of women and their eagerness to benefit from prevention of gynecological cancers and sexually transmitted diseases.


Eligibility criteria:
inclusion criteria: * women aged 30-49 years, able to comply with the study protocol exclusion criteria: * pregnancy * previous total hysterectomy * conditions impairing examination of the cervix
dual task balance exercises and vestibular stimulation for children with down syndrome

Conditions: Down Syndrome

Summary: children with down syndrome experience balance and postural control issues due to neuromuscular defects and face several impairments. for the improvement we will take 26 children with down syndrome, age between 7 to 14 years will be randomly assign into two groups. group a will perform dual task balance exercises and group b will perform vestibular stimulation exercises along routine physical therapy.all the data will be collected from rabia welfare hospital lahore by using pediatric balance scale, time up and go test and ktk test.the duration of study will be 10 months. data will be analyzed through spss version 25.00.

down syndrome is a genetic disorder experience balance issues due to neuromuscular defects which present with several impairments such as hypotonic, ligament laxity, decreased muscle strength, insufficient muscular co-contraction, inadequate postural control, intellectual disabilities, sensory integration difficulties and disturbed proprioception. the current study will be randomized clinical trial, data will be collected from rabia welfare hospital lahore. the study will include 26 patients equally divided into two groups and randomly allocated. inclusion criteria for the study will include patients diagnosed with down syndrome, age between 7 to 14 years(both genders), able to understand instructions and command necessary for intervention and children which able to stand momently but with history of frequent falling during walking. patients with atlanto axial instability, cardiopulmonary, orthopedic and neurological problems, cognitive impairment that interferes with communication, bmi of ≥30 kg/m2 and children which actively participating in sports will be excluded.group a will perform dual task balance exercises and group b will perform vestibular stimulation exercises along routine physical therapy.both groups will receive total of 16 sessions, 2 sessions per week for 8 weeks. each session lasted 30-45 min on average.then evaluate both groups on follow up.before and after intervention period, balance and gross motor coordination will be assessed by pediatric balance scale, time up and go test and ktk test. the reliability and validity of tools mentioned. data collection will be done before and after the intervention. data will be analyzed through spss version 25.00.

Eligibility criteria:
inclusion criteria: * patients diagnosed with down syndrome. * age between 7 to 14 years. * both the genders were included. * able to talk and comprehend instructions \& command. * children which able to stand momently but with history of frequent falling during walking exclusion criteria: * child with atlanto axial instability. * uncontrolled cardiopulmonary problems. * body mass index (bmi) of ≥30 kg/m2. * children with orthopedic problems and affecting gait. * cognitive impairment that interferes with communication. * neurological problems. * children which actively participating in sports

Keywords: down syndrome balance control vestibular stimulation dual task balance exercise gross motor coordination
the total neoadjuvant therapy for soft tissue sarcoma of the extremities

Conditions: Soft Tissue Sarcomas

Summary: for localized soft tissue sarcomas (sts) of the extremities, limb-sparing or conservative surgery with perioperative radiotherapy (rt) is the standard of care. however, several challenges persist. notably, there are exceedingly high rates of distant metastatic recurrence even after surgical resection and rt, and conventional fractionated radiotherapy has a prolonged duration (5-6 weeks). with advancements in rt technology, the gradual expansion of hypofractionated radiotherapy regimens enables significantly shorter treatment durations. promising recent reports on 1-week hypofractionated rt regimens, such as the 5x5 gy rt regimens, have demonstrated reasonable local control and acceptable toxicity in resectable sts.addressing the challenge of distant metastasis, previous studies have indicated that ai regimens are expected to eliminate micrometastases and improve survival in patients with sts at a high risk of distant relapse. therefore, the goal of this clinical trial is to investigate whether hypofractionated rt combined with a sequential chemotherapy（ai regimens）can enhance short-term treatment efficacy for extremity sts patients without compromising local control rates and increasing related toxicities


Eligibility criteria:
inclusion criteria: 1. primary soft tissue sarcoma of the extremities, with one of the following characteristics: high grade, ≥5cm or deep tumor, the need for neoadjuvant radiotherapy was determined after multidisciplinary consultation. 2. eastern cooperative oncology group (ecog) performance status 0 - 2. 3. age 18-75 years old. 4. histologic diagnosis of soft tissue sarcoma. 5. can tolerate radiotherapy and ai regimen treatment. 6. the function of major organs is normal. exclusion criteria: 1. there were no patients with gross tumors after unplanned mass resection in another hospital. 2. patients with other comorbidities cannot use ai chemotherapy: drug allergy, active bleeding, ulcers, intestinal perforation, intestinal obstruction, uncontrollable hypertension, grade iii-iv cardiac insufficiency (nyha standards), severe liver and renal insufficiency ( level iv) etc. 3. new malignant tumors within 5 years (except cervical carcinoma in situ or early cutaneous basal cell carcinoma). 4. pathological types: nonpleomorphic rhabdomyosarcoma, ewing sarcoma. 5. soft tissue sarcoma curable by simple expansion. 6. previous history of radiotherapy to the same site. 7. combined with distant metastasis (m1) or lymph node metastasis (n1). 8. have other severe medical comorbidities that preclude surgery or participation in the study. 9. previous exposure to chemotherapy.
study evaluating piperacillin-tazobactam on certain bacteria in hematology and oncology units

Conditions: Gram-Positive Bacterial Infections; Escherichia Coli Infections; Klebsiella Infections

Summary: to determine the value of increasing use of piperacillin/tazobactam as empiric therapy and restricting extended-spectrum cephalosporins in reducing the cases of esbl producing escherichia coli and klebsiella pneumoniae in hematology and oncology units


Eligibility criteria:
inclusion criteria: * eligible patients of either sex, 15 years of age or older * patients who are admitted to the department of hematology and oncology * provide written informed consent exclusion criteria: * patients who have hypersensitivity to β-lactam antibiotics * female who are pregnant or breast-feeding * any underlying conditions or non-infectious diseases that will be ultimately fatal within 30 days

Keywords: bacterial infections
evaluation of a smartphone-based screening tool for neonatal jaundice in a ugandan population

Conditions: Neonatal Jaundice

Summary: the general objective of this study is to evaluate the accuracy of a novel smartphone application that estimates bilirubin levels in newborns at hich mbarara.

the general objective of this study is to evaluate the accuracy of a novel smartphone application that estimates bilirubin levels in newborns at hich mbarara. the specific objectives for this study are: to evaluate the correlation between bilirubin estimates from a smartphone application and bilirubin measurements in serum in newborns with varying degree of jaundice to evaluate the correlation between bilirubin estimates from a smartphone application and bilirubin estimates from a standard transcutaneous device in newborns with varying degree of jaundice to evaluate the correlation between bilirubin estimates from a smartphone application and bilirubin estimates from visual inspection in newborns with varying degree of jaundice

Eligibility criteria:
inclusion criteria: * infants born with gestational age ≥37 weeks * birth weight ≥2000g and ≤4500g * age 1 - 14 days * infants requiring a blood sample (newborn screening / clinically suspected jaundice) exclusion criteria: * infants transferred to the paediatric ward for advanced treatment. * infants with a skin rash or other disease that affects the skin where measurements are performed. * infants that receive or have received phototherapy in the last 24 hours. * infants with an inborn disease