Kornimate/medical-research-clean huggingface dataset:
preoperative yoga and meditation for pediatric idiopathic scoliosis surgery

Conditions: Juvenile and Adolescent Idiopathic Scoliosis

Summary: this study has to purpose yoga and meditation before surgery for idiopathic scoliosis. protocol's observance will tell the investigators if it is feasible and appropriate in a university hospital center.

adolescent idiopathic scoliosis is the most common deforming orthopedic condition. preoperative anxiety is increased by operating time, post-operative pain level, neurological and hemorrhagic risk. the aim of the study was to purpose five sessions of yoga and meditation before surgery, remotely and face-to-face. observance of the 5 sessions will tell us if this protocol is feasible and appropriate. preoperative anxiety intensity will also be analyzed.

Eligibility criteria:
inclusion criteria: * age from 8 to 17 years * female and male gender * planned idiopathic scoliosis surgery exclusion criteria: * physical inability to do simple yoga postures during the initial session * neurological spinal deformity (cerebral palsy, severe epileptic disease, myopathy) * misunderstanding of the french language * recent history of characterized depressive episode: hospitalization and/or antidepressant treatment in the last 6 months * time between the first yomepop session and the date of the operation less than 28 days * refusal of permission to take picture * failure to obtain informed consent from one of the parents with parental authority * absence of affiliation to a french social security scheme or beneficiary of such a scheme * patient with a legal protection measure

Keywords: yoga meditation mindfulness anesthesia idiopathic scoliosis surgery anxiety children pediatric
the effect of cross-education on shoulder arthroscopy

Conditions: Rotator Cuff Tears; Rotator Cuff Injuries; Rotator Cuff Repair

Summary: the purpose of this study is to examine the effectiveness of a strength training protocol on the uninjured upper extremity either alone or with the addition of blood flow restriction (bfr) training on subjects who have undergone shoulder arthroscopy.

the purpose of this study is to examine the effectiveness of a strength training protocol on the uninjured limb either alone or with the addition of blood flow restriction (bfr) training on the status of the injured limb post shoulder arthroscopy. patients will be randomized into one of three standardized physical therapy (pt) groups after shoulder arthroscopy: control group (con), strength training on the uninvolved shoulder (str), strength training with the bfr on the uninvolved shoulder (bfr). all three patient groups will follow a standardized pt rehab protocol that is usual standard of care on the involved shoulder. the str and bfr group will follow a typical standard of care rehab protocol to the uninvolved side to investigate the potential effects of cross-education. isometric strength will be assessed utilizing handheld dynamometry (hhd) at kerlan-jobe during their regularly scheduled pre-operative and follow-up visits. patients age 18 and older undergoing shoulder arthroscopy for rotator cuff repair and/or biceps tenodesis. the study includes 3 visits which are standard of care pre-operative and post-operative visits. the duration of the study will be 14 weeks. 2 weeks to allow for a pre-op baseline strength assessment and 12 weeks post-op for the final assessment during the patients routine follow-up visit. physical therapy will be standardized for all three groups in terms of frequency and rehabilitation protocol. the only exercises that will be added will be to the intervention groups on the uninvolved side. patients will present to physical therapy 2-3 times/week during the duration of the study regardless of their group allocation.

Eligibility criteria:
inclusion criteria: * 18 years and older * diagnosed with rotator cuff injury * scheduled for rotator cuff surgery via shoulder arthroscopy exclusion criteria: * less than 18 years old * history of previous contra-lateral surgery or injury * previous ipsi-lateral upper extremity surgery * history of shoulder osteoarthritis

Keywords: biceps tenodesis cross-education blood-flow restriction training
implementation of a patient centered self-management program for patients with type 2 diabetes

Conditions: Type 2 Diabetes

Summary: translational study based on the american association of diabetes educators 7 behaviors to manage type 2 diabetes

the primary investigator will meet with patients that attend routine visits for diabetes 2 in the primary care office on a monthly basis to set behavior goals. behavior goals will be set by patient's choice of 4 out of 7 of the aade7 recommendations. the goals are health eating, being active, monitoring,taking medications, problem solving, healthy coping, and reducing risk. once the goal is chosen, the pi and patient will make a plan to address the goals on a monthly basis for four months. there will be pre and post questionnaires that will evaluate diabetes knowledge and self-efficacy. there will also be a pre and post measure of the patient's hemoglobin a1c which is a measurement that helps determine the extent of glycemic control over a three-month period. the goal of the study is to determine if translation of the aade7 behavioral goals into the primary care setting will make a difference in diabetes knowledge, self efficacy, and hemoglobin a1c.

Eligibility criteria:
inclusion criteria: * patients over 18 with hemoglobin a1c 7 mmol/mol or higher will be included in the study * patients willing to attend minimum of 4 monthly appointments for diabetes treatment * patients who give written consent to participate exclusion criteria: * patients below age 18, children are not treated in the facility for type 2 diabetes * patients who attend less than 4 monthly appointments for diabetes, * patients who do no give written consent to participate
human factors testing for otc use of the erchonia® lunulalaser

Conditions: Onychomycosis

Summary: human factors validation testing to assess the intended user's ability to correctly, safely, and effectively set-up, activate and operate the lunulalaser™ otc, to administer a treatment to a suitably qualified client, and to understand the information contained in the erchonia lunulalaser™ otc installation and proper use reference guide and box labeling.

this study is an uncontrolled simulated-use human factors validation testing design to assess the intended user's ability to correctly, safely, and effectively set-up, activate and operate the lunulalaser™ otc, to administer a treatment to a suitably qualified client, and to understand the information contained in the erchonia lunulalaser™ otc installation and proper use reference guide and box labeling. the study design is comprehensive in scope and conducted in a manner such that the results will be able to be generalized to the actual intended user and client population under intended conditions of actual use and be adequately sensitive to capture use errors arising from either the user interface design and/or the instructional and informative materials. study data will be collected in a manner that will facilitate analysis of the root causes of use errors or problems during the testing.

Eligibility criteria:
inclusion criteria: * 18 years or older. * male or female. * currently employed at a nail salon, beauty salon and/or spa, fitness and wellness spa, or the like. * in possession of qualification(s), current licensure(s), certification(s), and/or accreditation(s), as applicable, to perform their designated tasks at their place of employment, e.g., cosmetology degree, nail technician, esthetician, massage therapist etc. * voluntarily signed consent form. exclusion criteria: - none
capecitabine and cisplatin (xp)+sorafenib in advanced gastric cancer (agc): sorafenib+xp

Conditions: Advanced Gastric Cancer

Summary: there is strong scientific rationale for exploring the role of sorafenib with capecitabine and cisplatin (xp) in agc. xp is a new standard of care in agc and sorafenib is a novel signal transduction inhibitor that prevents tumor cell proliferation and angiogenesis through blockade of the raf/mek/erk pathway at the level of raf kinase and the receptor tyrosine kinases vegf-r2 and pdgfr-beta.


Eligibility criteria:
inclusion criteria: * having given signed written informed consent * unresectable advanced gastric adenocarcinoma, initially diagnosed or recurred * no history of chemotherapy or radiation * measurable disease according to response evaluation criteria in solid tumors (recist) * age 18-75 years * estimated life expectancy of more than 3 months * eastern cooperative oncology group (ecog) performance status 0-2 * adequate bone marrow function (absolute neutrophil count \> 1,500/µl, platelets \> 100,000/µl, hemoglobin \> 8g/dl), * adequate kidney function (creatinine clearance \> 60 ml/min) * adequate liver function (bilirubin \< 2.0 mg/dl, transaminases levels \< 3 times the upper normal limit \[5 times for patients with liver metastasis\]) exclusion criteria: * past or concurrent history of neoplasm other than gastric adenocarcinoma, except for curatively treated non-melanoma skin cancer or in situ carcinoma of the cervix uteri * major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to study treatment start * presence of central nervous system metastasis * obvious peritoneal seeding or bowel obstruction * evidence of serious gastrointestinal bleeding * peripheral neuropathy (national cancer institute common terminology criteria for adverse event version 3.0 \> grade i) * history of significant neurologic or psychiatric disorders * pregnant or lactating women, women of childbearing potential not employing adequate contraception * other serious illness or medical conditions * known allergy to study drugs

Keywords: gastric cancer capecitabine cisplatin sorafenib phase i phase ii
visualizing vascular endothelial growth factor (vegf) producing lesions in von hippel-lindau disease

Conditions: Von Hippel-Lindau Disease; Hemangioblastoma; Renal Cell Carcinoma; Pheochromocytoma; Pancreatic Neuroendocrine Tumor

Summary: von hippel lindau disease (vhld) is an inherited syndrome characterized by vascular malformations, kidney cancer, adrenal gland and pancreas tumors. the vhl protein is not functional in the different disease associated lesions which results in production of high amounts of vascular endothelial growth factor (vegf). currently there are no clinical, radiographic or molecular markers that can predict the natural history of a given lesion. with 89zr-bevacizumab positron emission tomography (pet) scanning, vegf can be visualized and quantified. the investigators hypothesize that 89zr-bevacizumab pet imaging is a useful tool to predict the behaviour of disease associated lesions in patients with vhld. adult patients with vhld who have had routine magnetic resonance imaging (mri) scans of central nervous system (cns) and abdomen will undergo a 89zr-bevacizumab pet scan. mri will be repeated within 12 months.


Eligibility criteria:
inclusion criteria: * clinically or genetically proven vhld * at least 1 measurable, vhl associated lesion in the cns * routine mri of the cns ≤ 6 weeks before inclusion * routine ct or mri of upper abdomen ≤ 3 months before inclusion or planned ≤ 3 months after 89zr-bevacizumab pet scan * age ≥ 18 years * written informed consent must be given according to good clinical practice (gcp), and local regulations exclusion criteria: * pregnancy * any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol, those conditions should be discussed with the patient before registration in the trial

Keywords: vascular endothelial growth factor von hippel lindau disease molecular imaging biomarker
breast cancer survivors: main physical and psychosocial problems after completion of treatment

Conditions: Breast Cancer

Summary: breast cancer directly affects women physically, psychologically and socially in the process of diagnosis, treatment and post-treatment. despite the improvement in conventional breast cancer treatments that led to longer disease-free survival, many patients still suffer from physical, psychological, social and spiritual problems after treatment. the neglect of physical and psychosocial problems faced by patients who are between 1 and 2 years after the end of treatment negatively impacts the quality of life of this population.

the purpose of the study is to assess the overall quality of life and measure the impact on women who have survived breast cancer for at least 1 year (12 months) and 2 years (24 months) after the end of primary treatment and to identify possible repercussions of breast cancer and its treatments associated with quality of life.

Eligibility criteria:
inclusion criteria: * breast cancer * adult women (age ≥ 20 years old and less than 60 years old) * patient who has been treated by surgery, with or without adjuvant chemotherapy * clinical stages i, ii and iii * patients considered cured, without history of recurrences * patients who completed treatment within a minimum of 1 year and are currently being undergoing outpatient follow-up exclusion criteria: * initial diagnosis of another type of cancer, other than breast cancer * bilateral breast cancer * patient unable to fill out the qol questionnaire * patient with disease recurrence * patient with metastatic breast cancer

Keywords: quality of life survivorship oncology
sleep to prevent evolving affecting disorders

Conditions: Insomnia, Primary; Depression

Summary: the primary objective of the proposed research is to determine the efficacy of digital cognitive behavior therapy (dcbti) in reducing severity of depression and also in preventing the incidence and relapse of depression among insomniacs. in addition, we will identify salient sociological/environmental variables, such as age, sex, education, socioeconomic status (ses), racial/ethnic minority-status, work schedule, child-care responsibilities (i.e., having children under the age of 3), stigma, that moderate the effects of this intervention.

the purpose of this study is to determine the effectiveness of digital cognitive behavior therapy for insomnia (dcbti) in reducing severity of depression and also in preventing the incidence and relapse of depression among insomniacs. dcbti is an online form of cognitive behavioral therapy (cbt) used with people who experience trouble sleeping at night (insomniacs). this study will allow us to determine whether this form of digital therapy is helpful in reducing the severity of depression and in preventing the development and relapse of depression in people suffering from insomnia. participants will be recruited from several well-developed sources, including the hfhs sleep center clinical database. once a participant meets inclusion criteria and provides consent, a link to the internet portal will be provided to complete the remaining survey questions. after completion of this assessment, participants will be automatically randomized to one of 2 active online insomnia treatment conditions. each treatment involves 6 weekly "sessions" which each take up to 20 minutes to complete. a post-treatment questionnaire immediately following the 6-week treatment phase will be completed. in addition, a follow up questionnaire assessment will be completed approximately 1 year after treatment. each of the 3 separate questionnaires will take 20-30 minutes to complete. participants will be compensated.

Eligibility criteria:
inclusion criteria: * meets diagnostic and statistical manual of mental disorders - fifth edition(dsmv) criteria for insomnia exclusion criteria: * lack of insomnia, untreated sleep disorder (e.g., obstructive sleep apnea, restless leg syndrome), bipolar disorder, history of seizure disorder, high depression chronicity (self-reported daily or near daily depressed mood and anhedonia)

Keywords: insomnia depression digital cbti online cbti
efficacy of l/a spray andl/a-soaked nasal packings on postoperative pain after nasal closed reduction

Conditions: Nasal Fracture

Summary: this study is perfored to investigate the efficacy of preoperative lidocaine spray and lidocaine-bupivacaine mixture-soaked nasal packing for acute postoperative pain after nasal closed reduction surgery.

to investigate the treatment of postoperative pain after nasal closed reduction surgery, we plan to investigate the effect of preoperative lidocaine spray and lidocaine-bupivacaine mixture-soaked nasal packing for the patinets undergoing nasal closed reduction under general aensthesia, compaing to the control group (normal saline spray and normal saline-soaked nasal packing).

Eligibility criteria:
inclusion criteria: * patients scheduled to receive nasal reduction surgery under general aensthesia exclusion criteria: * concomitant disorders (eg. facial bone fractures) concomitant surgery (eg. septoplasty)
randomized, double-blind, placebo-controlled trial of enema aloe vera gel in active ulcerative proctosigmoiditis.

Conditions: Aloe Vera Gel, Proctosigmoiditis, Remission, Trial, Ulcerative Colitis (UC)

Summary: aloe vera is used for the treatment of inflammatory bowel disease (ibd), but no data are present in regard the gel formulation as topical therapy in active ulcerative colitis.

44 ulcerative colitis (uc) patients were enrolled and randomly allocated to treatment for 4 weeks with oral mesalazine (800 mg three times daily) and enema (60 ml aloe vera gel) 1/day (n = 22, group a) or enema (60 ml placebo) (n = 22, group b).

Eligibility criteria:
inclusion criteria: * age over 18 years, mild to moderate active ulcerative proctosigmoiditis, diagnosed for the first time and no therapy started before. the maximum extension of the disease was accepted of 40-60 cm from the anal verge or distal disease. exclusion criteria: * an extension of disease above the sigma, renal impairment, pregnancy, lactation or established low compliance
move in mind: program for reducing musculoskeletal pain

Conditions: Musculoskeletal Pain; Chronic Pain

Summary: the present pilot study will explore the range of mental and physical health benefits associated with a rolfing®-based intervention program ("move in mind"). to assess the effects of this program on pain management and various psychological outcomes, the investigator's study will be offered to individuals with mild chronic musculoskeletal pain (e.g., lower back pain, neck pain, shoulder pain, knee pain, arthritic pain). shortened from ten to six sessions and adapted to a group setting by rolfing® instructor monica canducci, the intervention will be delivered weekly by ms. canducci, who is certified in rolfing®. the program will target the potential associations of the move in mind program with better pain management (primary outcome) as well as increased body awareness and presence, increased well-being, and better stress management (secondary outcomes). interested participants will be asked to complete a battery of questionnaires and psychometric scales to assess the variables of interest before (baseline) and after their participation in the move in mind program (six-week follow-up). a waitlist control group will also be assessed at baseline and follow-up and will then receive the move in mind sessions subsequently and also assessed after their participation.


Eligibility criteria:
inclusion criteria: * 18 or older * experiencing a type of mild musculoskeletal pain (e.g., pain related to the muscles, ligaments, bones, joints, or nerve compression) exclusion criteria: * pregnant * receiving treatment for severe chronic pain * have had recent concussions or fractures as a result of accidents
guided imagery & music in cancer

Conditions: Cancer, Breast; Cancer, Metastatic; Cancer Ovaries; Cancer Uterus Cervix

Summary: this is an rct pilot study to explore the potential effects of the guided imagery \& music method for women with breast or gynecologic cancer, during active treatment. the study explores the potential impact in quality of life parameters such as mood, fatigue, and hope.

guided imagery and music is a music-assisted psychotherapy method which has been used as a complementary, supportive psychosocial therapy in cancer care. however, its effects have never been explored during the period of active chemotherapy or radiotherapy treatment in various cancer populations, and especially gynecologic and breast cancer. this pilot study is an effort to explore the feasibility of the method to increase quality of life in this population by possibly reducing side-effects of treatment such as fatigue, improving mood, and building resilience as expressed through levels of hope.

Eligibility criteria:
inclusion criteria: * speaking greek * receiving chemotherapy or radiotherapy treatment for breast or gynecologic cancer * first occurrence or metastatic * have an interest in engaging in creative psychotherapies through music exclusion criteria: * women with active psychosis or ptsd symptomatology * women receiving other psychological support * women too ill to participate according to doctors' instructions

Keywords: receptive music therapy guided imagery & music (gim) chemotherapy radiotherapy breast cancer gynecologic cancer
sebbin silicone gel-filled testicular implants

Conditions: Complication; Prosthesis Durability

Summary: this study is part of the clinical evaluation of sebbin silicone gel-filled testicular implants, included in the technical file of the device. the aim of the study is to gather additional data about the safety and effectiveness of the device.


Eligibility criteria:
inclusion criteria: * the patient is an adult or a child at the time of implant placement with sebbin implant. * the patient is candidate to a unilateral or bilateral testicular implant placement with sebbin implant. * the patient has been informed of the study, has read the patient information letter and -provided oral consent. exclusion criteria: * the patient has silicone implants somewhere else than in the scrotal sac. * the patient was diagnosed with one of the following pathologies: * systemic lupus erythematous, sjogren syndrome, scleroderma, polymyositis, or any other connective tissue disease. * rheumatoid arthritis, crystalline arthritis, infectious arthritis, spondyloarthropathies, or any other inflammatory arthritic disease. * arthritis, fibromyalgia, chronic fatigue syndrome, or any other mechanic or degenerative non-inflammatory rheumatic disease. * the patient has a pathology that could delay healing. * custom-designed implants are used for surgery.