Kornimate/medical-research-clean huggingface dataset:
use of plasma ctdna methylation haplotypes in detecting local residual or lymph node metastasis

Conditions: Colorectal Cancer; Lymph Node Metastases

Summary: this is a prospective, clinical study. this study is to evaluate the sensitivity of plasma ctdna methylation haplotypes in detecting local residual or lymph node metastasis.

colorectal cancer (crc) is the third most common cancer worldwide, the second deadliest cancer in the united states. dna methylation is a commonly used biomarker for non-invasive crc detection in plasma. the low sensitivity of blood-based tests is due to several limitations of detecting ctdna in early-stage cancer. we developed and validated a high-throughput methylation-based blood test highly sensitive for colorectal cancer and precancerous lesions. this previously established colorectal tumor-specific plasma ctdna methylation markers (diagnostic model established by next-generation sequencing of 2181 gene loci methylation) had a high sensitivity in crc patients and a high specificity in healthy individuals in a large retrospective sample study. this prospective, clinical study is to further evaluate the sensitivity of plasma ctdna methylation haplotypes in detecting local residual or lymph node metastasis.

Eligibility criteria:
inclusion criteria: * patients with endoscopically removed malignant polyps. * male or female ≥ 18 years of age on the day of signing informed consent. * patients who received surgical resection following removal of malignant polyps by colonoscopy. * patients must have a performance status of ≤1 on the ecog performance scale. * written informed consent must be obtained from patient or patient's legal representative and ability for patient to comply with the requirements of the study exclusion criteria: * patients received adjuvant treatment prior to the surgical resection. * patients received blood transfusion two weeks before or during the surgical resection. * patients with unresected advanced colorectal adenoma. * patients who are positive for human immunodeficiency virus (hiv), hepatitis b or hepatitis c. * patients who are pregnant. * patients who are alcoholic or drug abusers. * patients with a history or current evidence of any condition or abnormality that might confound the results of the study, interfere with the patient's participation for the full duration of the study, or is not in the best interest of the patient to participate, in the opinion of the investigator.

Keywords: colorectal cancer lymph node metastases local residual
comparison of the quadratus lumborum block with the transversus abdominis plan block

Conditions: Postoperative Pain

Summary: in this study, investigators aimed to compare the quadratus lumborum block and the transversus abdominis plan block for postoperative pain control after laparoscopic cholecystectomy

after ethical committee approval, informed written consent will be obtained from all patients. a sample size of 60 patients (30 per group) was calculated based on 15% reduction in morphine consumption with 0.05% significance and a power of 0.8. consenting patients scheduled to have elective laparoscopic cholecystectomy under general anesthesia will be randomized to receive bilateral qlb or tap before the surgery. the dose of local anesthetic in both groups will be 20 ml 0.25% bupivacaine. allocation to either group will be done using permuted block randomization method. patients will be taken to the block room 1 hour before surgery. ecg, nibp and spo2 monitor will be done. the iv access route will be provided. the patient will be given 0.03 mg / kg iv midazolam for routine premedication. block will be applied by a blind anesthetist to the other data of the study. under ultrasound guidance a 22 gauge sonoplex needle will be used for both techniques. the calculated dose of local anesthetic will be injected bilaterally with intermittent aspiration. the spread of injectate will be seed on ultrasound. the procedure time for both blocks will be recorded and 30 minutes after the procedure is completed, and the patient will be taken to the operation room. general anesthesia will be applied to the patient in the operation procedure in the standard procedure. intraoperative heart rate and / or mean arterial pressure is increased to 20% of the basal value and 0.5 mcg / kg iv fentanyl will be added. 30 minutes before the end of operation, 1 mg iv paracetamol and nsaid (dexketoprofen) 50 mg iv will be administered to the patient before extubation. the patient will be infected with iv pca in the morphine. pc 1 mg iv bolus dose will be adjusted to 10 minutes of locked-out period. in the postoperative period, 4 \* 1 gr / 24 h iv paracetamol will be given to each patient. all patients will be assessed postoperatively by a blinded investigator: in the post-anesthesia care unit and at 0, 2, 4, 6, 12 and 24 h postoperatively.

Eligibility criteria:
inclusion criteria: * asa 1-2-3 * elective laparoscopic cholecystectomy * 19-65 years * written informed consent exclusion criteria: * patient refusal local infection at the site of injection * allergy to study medications sepsis anatomic abnormalities systemic anticoagulation or coagulopathy - inability to comprehend or participate in pain scoring system * inability to use intravenous patient controlled analgesia

Keywords: postoperative pain laparoscopic cholecystectomy quadratus lumborum block transversus abdominis plan block
a study on treatment for patients with brafv600e mutant metastatic colorectal cancer (mcrc)

Conditions: Metastatic Colorectal Cancer; BRAF V600 Mutation

Summary: previous studies have shown that brafv600e mutant mcrc patients have a shorter survival time than braf wild type mcrc patients. for chinese patients, however, it remains unclear about the braf gene mutation rate, diagnosis, prognosis and survival data in people with brafv600e mutant mcrc . this real-world, multicenter non-interventional study (nis) will describe the mutation rate, treatment patterns, effectiveness and safety of current treatment regimens in brafv600e mutant mcrc patients in china.


Eligibility criteria:
inclusion criteria: * diagnosis of histologically or cytologically confirmed crc that is metastatic and unresectable * presence of brafv600e mutation in tumor tissue, as confirmed by a local assay exclusion criteria: * patients with previous chronic inflammatory bowel disease, chronic diarrhea or recurrent bowel obstruction patients with symptomatic brain metastases active clinical severe infection
a parent-only group cognitive behavioral intervention for children with anxiety disorders: a control group study

Conditions: Anxiety Disorders

Summary: the fact that cognitive behavioral therapy (cbt) is a well known efficacious intervention for children with anxiety disorders (ad) is undeniable. however, most children with ad have limited access to cbt. there is some controversial evidence on group cbt in ad involving families in treatment of their children and a published article on efficacy of a parent only group cbt for these children. considering these data, the investigators hypothesized that teaching anxiety-fighting skills to parents of children with ad would diminish anxiety symptoms of both parents and children and improve family relational functioning.

all children and their parents were interviewed using k-sads-pl-persian version, a semi-structured diagnostic interview to confirm the diagnoses and assess possible comorbidities. all diagnostic assessments were conducted by a fellowship of child and adolescent psychiatry. following assessment, once the participants reached twenty members, they were invited to complete child and parent self-report measures. the level of child functioning and family relationship functioning were also evaluated. then they were randomly allocated to either parent training (n=20) or a 6 week wait-list (n=22) groups. during 2 weeks after treatment the assessments were repeated and satisfaction ratings were collected for the intervention group.

Eligibility criteria:
inclusion criteria: 1. having dsm-iv criteria for a primary diagnosis of generalized anxiety disorder (gad), separation anxiety disorder (sad), social phobia, or specific phobia. 2. age 6 to 12 years, 3. receiving one of selective serotonin reuptake inhibitor (ssri) medicine at the stable dose for at least 8 weeks before baseline assessments and during the study, 4. at least one parent willing to participate and give written consent. exclusion criteria: 1. diagnosed as bipolar disorder, autism spectrum disorders or mental disability by data obtained in personal history and clinical assessments, 2. there was a change in drug regime during the study period, 3. if parents missed more than 2 of 6 sessions of treatment.

Keywords: parents group cognitive behavioral intervention anxiety disorder children friends program
effect of insulin on wound healing-a randomized controlled trial

Conditions: Wound Heal

Summary: a randomized controlled trial examining the effect of insulin on wound healing in both diabetics and non diabetic patients in a local health center in bahrain.

this is a double blinded rct comparing the effect of insulin on wound healing in both diabetics and non diabetics. the study will run in primary care setting in bahrain. the aim of this study is to heal wound in an innovative way. and the objective: to evaluate the effect of topical insulin administration on wound healing. all adult patients with skin wounds attending primary health care center will be included in the study. patients with acute and chronic wounds of the upper and lower extremities will be eligible to participate.

Eligibility criteria:
inclusion criteria: * adult patients with texas 1 and 2 wound criteria exclusion criteria: texas 3 and 4 wound criteria -
effectiveness of a multidisciplinary treatment and structured education programme

Conditions: Type 1 Diabetes

Summary: this trial compared an structured education programme and multidisciplinary treatment vs an standard treatment in type 1 diabetes patient, the primary outcome is glycemic control at 6-month follow up and secondary outcome are cardiovascular risk factors control, diabetes related distress, anxiety and depressive symptoms, hypoglycemia awareness.

both groups will received individualized treatment in the clinic, the intervention group will consist of 12 educational sessions during 4 months, and multidisciplinary treatment each month given by endocrinology, nutrition and psychology during 4 months, the control group will received education in outpatient clinic of endocrinology and will be sent as referral to specialties of nutrition and psychology as standard follow-up of the clinic.

Eligibility criteria:
inclusion criteria: * type 1 diabetes * diabetes duration \>1 year * bmi 18.5-40kg/m2 * a1c 6.5-13% exclusion criteria: * pregnancy * dementia or severe cognitive impairment * uncontrolled psychiatric disorder * absence of \>20% of the educational sessions

Keywords: type 1 diabetes autoimmune diseases diabetes education programme dsmes diabetes self-management education and support t1d insulin-dependent diabetes juvenile diabetes
improving quality of life for teenagers with asthma

Conditions: Asthma in Children; Asthma

Summary: background: asthma is a long-term lung condition affecting 1 in 11 children and young people in the uk. many teenagers have well controlled asthma, but a significant number continue to experience regular symptoms and asthma attacks leading to hospitalisations. while non-adherence to medication is a factor, teenagers also face challenges like changing relationships with parents and peers, avoiding triggers like smoking, and fitting in treatment with daily life demands. healthcare professionals (hcps) also face difficulties in managing teenagers with asthma. a previous study, funded by asthma + lung uk, developed a new approach to manage teenage asthma by focusing on self-efficacy, which is how confident one feels about performing a task. teenagers completed the adolescent asthma self-efficacy questionnaire (aaseq), which identified areas where they needed more support. hcps then tailored their consultations to address these needs. this approach improved the teenagers' confidence in self-managing their asthma. improving quality of life (qol) is a key goal in asthma care. therefore, the aim of this study is to determine if the self-efficacy approach improves qol for teenagers with asthma. methods: teenagers aged 12-18 years with asthma will be recruited from hospital clinics. they will be randomly assigned to one of two groups: 1. teenager will complete the aaseq at the start of their appointment. the hcps will use this to focus the consultation on areas where the teenager needs support in self-managing their asthma. 2. teenager will have their usual consultation with the hcp. three months after the appointment, the qol will be compared between the two groups using a standardised questionnaire. impact: if the self-efficacy approach proves to be beneficial, it could help hcps to empower teenagers to better manage their asthma and ultimately improve their quality of life.


Eligibility criteria:
inclusion criteria: * adolescent aged 12-18 years * attending a paediatric respiratory clinic * informed consent from adolescent aged ≥16 years, and assent plus parent/guardian consent for adolescents aged ≤16 years * paediatric asthma quality of life questionnaire score \<5.5 points exclusion criteria: * aged 0-11 or over 18 years * other significant long-term medical condition that has a day-to-day impact on their lives (except for co-existing allergic conditions) * adolescent or parent/guardian unable to communicate sufficiently to complete consent forms.

Keywords: asthma adolescent self-efficacy quality of life asthma control
prospective study of hormone levels after bariatric surgery

Conditions: Obesity

Summary: this project will study the effects of surgery for obesity on bone metabolism and hormones that regulate appetite.

subjects will be recruited from the outpatient obesity and surgical clinics at columbia-presbyterian medical center after they have chosen to undergo a surgical procedure. the groups will not be randomized. rather, they will decide on their choice of surgery along with their physicians. the patients will be evaluated pre-operatively and followed post-operatively for 5 years. initial evaluation will include a complete history and physical examination, measurement of calcium, parathyroid hormone (pth) and vitamin d, and assessment of skeletal health using markers of bone turnover and bone mineral density.

Eligibility criteria:
inclusion criteria: 1. adult male or female \> 18 years of age 2. scheduled to undergo bariatric surgery exclusion criteria: 1. vitamin d deficiency 2. primary hyperparathyroidism 3. treatment with lithium or thiazide diuretics which may alter pth levels 4. osteomalacia 5. untreated hyperthyroidism, liver disease, cushing's syndrome, rheumatoid arthritis, myeloma or paget's disease 6. impaired renal function (serum creatinine \>2.0mg/dl) or history of renal osteodystrophy 7. use of any anti-obesity medications for over 2 weeks 90 days prior to study 8. participation in any research study 90 days prior to study 9. any malabsorption syndromes such as celiac sprue 10. previous bariatric surgery

Keywords: obesity insulin resistance bariatric surgery gastric banding gastric bypass
human dopamine transported imaging in cocaine abuse: 1 - 1

Conditions: Cocaine-Related Disorders

Summary: the purpose of this study is to determine the density of da transporters during prolonged cocaine abuse and during withdrawal from cocaine use. this aim will test the hypothesis that da transporters are altered by cocaine abuse and reestablished during withdrawal.


Eligibility criteria:
please contact site for information.

Keywords: cocaine dependence
properties of myocardial microcirculation in patients with different pathomorphological substrates, before and after recanalization of coronary artery cto

Conditions: Chronic Total Occlusion of Coronary Artery

Summary: this study will evaluate the changes in myocardial microcirculatory parameters of the collateral donor artery after recanalization of coronary artery chronic total occlusion.

this study will include patients with chronic total occlusion (cto) of one coronary artery who will undergo the recanalization of the cto. before the procedure, myocardial viability, ischemia, functional parameters of the collateral donor blood vessels, echocardiography, and quality of life will be assessed. after the recanalization, these parameters will be assessed again 24h and 6 months after the procedure.

Eligibility criteria:
inclusion criteria: * patients over the age of 18 with signed informed consent to participate in the study * presence of one cto on native coronary arteries (with timi 0 flow) * presence of clinical indication for attempting a pci for cto (at least one of the criteria present): 1. symptoms of typical stable angina 2. presence of inducible ischemia in the territory of the occluded artery 3. presence of viable myocardium in the territory of the occluded artery * the diameter of the occluded artery ≥2.5mm exclusion criteria: * acute coronary syndrome in the past month * existing contraindication for administration of dual antiplatelet therapy in the duration of 12 months * contraindications for implanting the drug-eluting stents * existence of 2 or more ctos on native coronary arteries (with timi 0 flow) * severe tortuosity or calcifications of the coronary arteries * left ventricle aneurysm * previous coronary artery bay-pass graft or any other cardiac surgery * previous myocardial infarction in the coronary artery territory different from the cto * ejection fraction of the left ventricle less than 30% * permanent atrial fibrillation * pregnancy * patients with known allergy to iodine contrast that cannot be controlled with medication * patients who are unable or unwilling to cooperate and come for check-up visits * life expectancy less than a year * hemorrhagic diathesis, coagulopathy, or rejection of blood transfusion

Keywords: chronic total occlusion coronary flow reserve
sglt2 inhibitors prophylaxis against post-contrast acute kidney injury in diabetic kidney disease?

Conditions: SGLT2i Kideny Protection Against Contrast in Diabetic Kidney

Summary: we will look for the possible effect of sglt2i as a single agent to prevent post-contrast acute kidney injury in diabetic kidney disease.

population of study o group 1 : 1. st group will receive normal saline 10ml/kg over 6 hours before and 6 hours after radiocontrast. o group 2 : 2. nd group will receive allopurinol 300 mg and linagliptin 5 mg once daily o group 3 : 3. rd group will receive the sglt2i empagliflosin 25 mg once daily o group 4 : 4. thwill receive allopurinol and empagliflosin. inclusion criteria : o age: more than30years, diabetes,diabetic kidney disease,gfr: more than30ml/min/1.73m2 exclusion criteria : o diabetics patients with gfr less than 30 ml/min/1.73 m2. sample size ( number of participants included ) : 800 patients fayoum university faculty of medicine scientific research ethics committee methodology in details : the chosen patients will be randomly allocated to 4 equal groups that will receive their prophylaxis for 48 hours before and 48 hours after the radiocontrast administration. baseline serum creatinine will be obtained 72 hours before the planned intervention and before administration of any protective protocol and follow-up serum creatinine will be obtained 72 hours and 1 week after contrast administration. the first control group will receive normal saline 10ml/kg over 6 hours before and 6 hours after radiocontrast. saline should be given by infusion pump to guarantee steady rate of infusion. 2nd group will receive allopurinol 300 mg and linagliptin 5 mg once daily. 3rd group will receive the sglt2i empagliflosin 25 mg once daily, and the 4th will receive allopurinol and empagliflosin.

Eligibility criteria:
inclusion criteria: * age: more than30years, diabetes, diabetic kidney disease, gfr: more than30ml/min/1.73m2 exclusion criteria: * diabetics patients with gfr less than 30 ml/min/1.73 m2.
aerosol particle size and breathing pattern during inhaled furosemide

Conditions: Healthy Volunteers

Summary: the study hypothesises that the variability in relief of air hunger with inhaled furosemide that is reported in previous studies can be explained by the breathing pattern adopted during the inhalation and the droplet size in the aerosol, both of which would influence the site of deposition of the aerosol in the lungs

recent studies suggest that inhaling furosemide as a mist reduces air hunger in healthy volunteers in whom air hunger is induced experimentally in the lab. however, how much reduction varies among individuals. it is not known if the way the mist is breathed (slow/deep or fast/shallow) or the size of the droplets in the mist (large or small) can explain the variation in relief. both of these factors can influence the site of deposition of the aerosol in the lungs in this study the relief of air hunger (induced by hypercapnia and constrained ventilation) will be compared when furosemide is inhaled quickly or slowly, and when the mist has large or small droplets. 20 healthy volunteers will be recruited. after a practice session, the 'air hunger' test will be performed before and after 4ml of a 10mg/ml solution of furosemide (40mg). this will be repeated on 4 separate test days using a different method of inhaling the furosemide on each day.

Eligibility criteria:
inclusion criteria: - healthy volunteers aged 18 and over exclusion criteria: * on any medication, including herbal medication (other than mild analgesics, vitamins and mineral supplements or, for females, oral contraceptives), whether prescribed or over-the-counter, in the two weeks prior to test sessions involving administration of furosemide or saline. * female participants who are pregnant, lactating or planning pregnancy over the course of trial * a medical history of heart, kidney or liver disease/electrolyte disturbances/ immunosuppression/frequent fainting episodes/copd/nasal polyps/addison's/acute porphyria/significant prostatic symptoms/acute gout attack/life expectancy \<6months or history of allergic reaction to furosemide and/or any of the other ingredients of furosemide or amiloride, sulfonamides or sulphonamide derivatives, such as sulfadiazine or co-trimoxazole * any other significant disease or disorder which, in the opinion of the investigator, may either put the participants at risk because of participation in the trial, or may influence the result of the trial, or the participant's ability to participate in the trial. * have participated in another research trial involving an investigational product in the past 4 weeks.
lung ultrasound - prospective study

Conditions: Respiratory Distress of Newborn

Summary: the goal of this clinical trial is to determine whether lung ultrasound can predict extubation success in neonates with respiratory distress. participants will undergo a lung ultrasound pre- and post-extubation.


Eligibility criteria:
inclusion criteria: * infants born at unitypoint health meriter hospital and university of minnesota admitted to the neonatal intensive care unit (nicu) with respiratory distress requiring intubation * meeting the extubation readiness criteria per the attending neonatologist exclusion criteria: * known major congenital disease (chromosomal abnormality, heart disease, respiratory malformation) * neonates with parents that are less than 18 years old