Kornimate/medical-research-clean huggingface dataset:
cardiac function in swimming-induced pulmonary edema (sipe)

Conditions: Swimming Induced Pulmonary Edema (SIPE); Pulmonary Edema; Lung Diseases; Heart Function Tests

Summary: acute or chronic cardiac dysfunction could be a contributing factor to swimming-induced pulmonary edema (sipe). knowledge on cardiac function in sipe is limited and recommendations for cardiac evaluation of patients with sipe are lacking. the present study was designed to assess cardiac function in patients with sipe and in asymptomatic swimmers.

swimming induced pulmonary edema (sipe) is an unusual condition occuring during swimming in cold open water. sipe is characterized by acute onset of dyspnea and cough, excessive sputum and occasionally hemoptysis. reversible myocardial dysfunction has been described in swimmers with sipe and divers with immersion pulmonary edema (ipe). cardiac dysfunction has also been discussed as a contributing factor triggering sipe. however, prevalence, severity and prognosis of myocardial dysfunction in patients with sipe is unknown. official recommendations for cardiac evaluation of patients after an acute episode of sipe is lacking. this case-control-study intends to assess cardiac function in patients with sipe and in asymptomatic swimmers. we study a large cohort of approximately 12 000 swimmers during vansbrosimningen, sweden's biggest annual open water event, with a yearly incidence of sipe of about 0,4%. cardiac function is evaluated after swimming as well as at rest by echocardiography, 12-lead electrocardiogram and cardiac biomarkers (troponin i, nt-pro-bnp).

Eligibility criteria:
inclusion criteria: for patients: * respiratory symptoms during or after swimming at the vansbrosimningen open water swimming event * diagnosis sipe by signs of pulmonary edema on lung ultrasound * peripheral oxygen saturation ≤95% for controls: * completion of a swimming race of the vansbrosimningen open water swimming event. * no respiratory symptoms during or after swimming * no signs of pulmonary edema on lung ultrasound * matched to patients with sipe regarding sex and age exclusion criteria: * declined consent * hemodynamic instability or decreased consciousness

Keywords: echocardiography electrocardiography troponin
polygraphy at home for neuromuscular patients under non-invasive mechanical ventilation

Conditions: Neuromuscular Diseases

Summary: the primary objective of the study is to evaluate the feasibility, the quality and the utility of a polygraphic control at home in order to appreciate the efficacy of the night time non-invasive ventilation (allowing to optimize the ventilator settings when the results are not satisfactory).


Eligibility criteria:
inclusion criteria: * patient ≥ 18 years; * patient with chronic respiratory insufficiency has just been posed non-invasive ventilation (niv) in the hospital, according to the latest international recommendations ; * affiliation to the social security scheme; * patient has signed the informed consent form to participate to the study. exclusion criteria: * patient refusal; * patient under guardianship; * patient under ame scheme; * patients living more than 40 km from reference center; * patient depending on mechanical ventilation (more than 6 hours daily); * rapidly or reversible evolutive neuro-myopathy (amyotrophic lateral sclerosis, guillain barré syndrome, myasthenia).

Keywords: neuromuscular diseases polygraphy
home-based exercise and weight control program for pain control in overweight elderly with osteoarthritis of the knee

Conditions: Chronic Diseases; Obesity; Osteoarthritis; Pain

Summary: the purpose of this study is to determine whether a home-based exercise and weight control program applied to elderly overweight individuals with painful osteoarthritis of the knee, would result in pain reduction.

osteoarthritis (oa) is the most common chronic disease in the united states (u.s.). arthritis is a leading chronic illness among older adults in the u.s. approximately 40% of individuals above 60 yr of age have oa of the knee. the primary objective of the proposed study is to determine whether individuals who are overweight with oa of the knee and who complete a 24-week home-based exercise program combined with a weight control intervention program will report significantly less pain (as measured by the womac) than volunteers who participate in home-based exercise (ex) only, weight control intervention (wc) only, or standard clinical care (c). the secondary objectives of the proposed research are to determine whether overweight individuals with oa of the knee who complete the ex+wc program, when compared to subjects who are randomly assigned to a e, wc or c groups, demonstrate significant improvement in the following health risk profile variables: (a) improved physical function (measured by the functional performance inventory), (b) improved capacity to perform stair climbing and descending, (c) improved strength, (d) increased lean body mass, (e) increase in physical activity at home (measured by pedometer step count). the proposed clinical trial will utilize a prospective, randomized two by two factorial design. descriptive and ancova statistical method will be applied for data analyses.

Eligibility criteria:
inclusion criteria: * male \& female 50 years old * diagnosis of osteoarthritis by american college of rheumatology criteria * knee radiographs of kellgren and lawrence grade 2-4 * american arthritis association functional class 1-3 * body mass index of 27 exclusion criteria: * knee arthritis which did not meet american college of rheumatology (acr) oa criteria * unable to engage in exercise or follow instruction * limited shoulder range of motion

Keywords: elderly exercise lean body mass muscle strength nutrition program pain control stair climb walking distance weight loss
psychologic impact of covid-19 pandemic on the hospital staff of the nouvelle aquitaine area

Conditions: Covid19; Personnel, Hospital; Work-Related Condition; Work-Related Stress Disorder

Summary: evaluation of the psychological impact of the covid-19 pandemic on hospital staff in the french nouvelle aquitaine area, through a longitudinal study with repeated self-administered psychologic scales

evaluation of the psychological impact of coronavirus disease 2019 (covid-19) on hospital personnel in nouvelle aquitaine. impsy-cov upon recent outbreaks of new diseases (sars, mers-cov, ebola) have led to the emergence of psychiatric disorders in healthcare workers , such as post-traumatic stress , anxiety (e.g., panic attacks) or depressive episodes. observed similarities in between propagation patterns of sars-cov-2 and sars, alow us to expect the occurence of similar psychiatric disorders in covid-19 context to those described (vignaud, prieto, 2020). the study is set up to assess the psychological state of hospital personnel in the working conditions of treating covid-19 suffering patients. 87000 hospital staff workers from the nouvelle aquitaine region will be invited to take part in the study. this includes medical and non-medical professionals from general and psychiatric hospitals exposed to covid-19. study design. the protocol shows two phases and five measurement timepoints. in the initial phase (t0), eligible persons will be contacted via email. those wishing to participate will then consent, answer socio-demographic questions and a series of psychology questionnaires. in the longitudinal phase, participants will be again invited to answer the same series of questionnaires four times: one month after the initial phase (t1), 3 months after (t2), 6 months after (t3) and 12 months after (t4). statistical analysis. in order to identify the consequences generated by covid-19 in hospital personnel through a longitudinal protocol, several statistical analyses are considered, including logistic and linear regressions as well as anova and manova. expected outcomes. the study will assess the occurrence and the evolution of psychological distress and identify vulnerability factors that may trigger psychiatric disorders in these situations. the study will also provide an opportunity to improve the supporting actions of professionals affected by the crisis.

Eligibility criteria:
inclusion criteria: * 18 years or more * hospital workers exposed to covid-19 * consented to participate to the study * master the french langage * understanding of type, objectives and study methology * accept an on-line evaluation * benefit from health insurance exclusion criteria: * refuse to participate * pregnant or breastfeeding woman * be under measure of legal protection: guardianship, curatorship or safeguard of justice.

Keywords: covid-19 mental health anxiety hospital personnel longitudinal pandemic
evaluation of handling and possible complications related to the newly developed angular stable locking system (asls)

Conditions: Humerus Fracture; Femur Fracture; Tibia Fracture

Summary: in many cases, the existing locking bolts and screws in intramedullary nails do not provide sufficient stability. due to the play between screw and nail, the reduction can be lost and the instability can result in malunions, nonunions, or pseudoarthrosis. consequently, secondary angular fracture dislocation (defined as a difference of the angle of 10° or more from the post-operative to the follow-up x-rays) can be observed in approximately 30% of patients after conventional intramedullary nailing of proximal third tibial fractures and in approximately 0-2% in patients with distal third tibial fractures. therefore, an angular stable locking system for intramedullary nails (asls) was developed to reduce the risk of secondary loss of reduction by providing axial and angular stability. asls provides angular stable fixation between nails and screws with resorbable sleeves used as dowels in the nail locking holes. the present study evaluates the handling of asls and the surgeon's compliance as well as any complications occurring during the baseline and the follow-up period in patients with proximal and distal tibial, femoral and humeral fractures treated with intramedullary nails. furthermore, the relationship of any occurred complications to asls will be assessed.


Eligibility criteria:
inclusion criteria: * the patient is ≥ 18 years old * one of the following bones is fractured so that the fracture is affecting the proximal or the distal third of the bone without affecting the joint surface: humerus, femur, tibia * the fracture is fixed with one of the following cannulated implants humerus: expert hn, expert phn. femur: expert lfn, expert rafn, cfn, dfn, afn. tibia: expert tn, ctn. * the patient is willing and able to participate in the study follow-up according to the cip. * the patient is able to understand and read local language at elementary level. * the patient is willing and able to give written informed consent to participate in the study. exclusion criteria: * the patient is legally incompetent. * preexistent malunion or nonunion of the bone that is planned to be treated with asls. * the patient suffers from a polytrauma (multiple injuries, whereof one or the combination of several injuries is life-threatening). * the patient suffers from active malignancy. * the patient is affected by drug or alcohol abuse. * the patient has participated in any other device or drug related clinical trial within the previous month.

Keywords: angular stable locking system handling test complications
computer guided versus conventional augmentation using bone ring

Conditions: Bone Resorption

Summary: using bone ring grafts with simultaneous implant placement after three-dimensional augmentation of severely defective bone ridges using computer-guided surgical templates. the study compares accuracy effectiveness by mimics software

to study the effectiveness of computer guided surgical stents in ridge augmentation with implant insertion compared with free hand augmentation -population/intervention/comparator/outcome (pico)- population (p): patients with massive bone resorption horizontally and vertically, severe bone loss around teeth, periodontal disease or traumatic extraction in partially edentulous maxillary anterior region requiring implant insertion. intervention (i): simultaneous implant placement with ridge augmentation using computer guided surgical templates with prf. comparator (c): free hand simultaneous implant placement with ridge augmentation. outcome (o): patient esthetic satisfaction - augmentation and implant insertion accuracy

Eligibility criteria:
inclusion criteria: 1. patients with insufficient alveolar ridge or severe alveolar bone resorption horizontally and vertically in partially edentulous maxillary anterior region. 2. medically free patients in order to be a confounding factor on the final results. 3. highly motivated patients. 4. good oral hygiene. 5. patients physically able to tolerate surgical and restorative procedures. exclusion criteria: 1. young patients (incomplete bone growth). 2. patients with any systemic disease that could affect bone healing. 3. patients allergic to local anaesthetic agent. 4. pregnant or lactating females. 5. presence of any pathosis in the area. 6. history of oral radiotherapy. 7. history of prolonged steroid use. 8. psychological disorders.
vorapaxar study for maturation of av fistulae for hemodialysis access

Conditions: AV Fistula

Summary: the objectives of this study are: 1. to determine if vorapaxar safely improves arteriovenous (av) fistula functional maturation when administered during the maturation process compared with placebo. 2. to determine if vorapaxar safely improves av fistula patency, allowing for secondary procedures to aid in fistula maturation compared with placebo. 3. to determine if vorapaxar safely facilitates successful cannulation of av fistulas for hemodialysis compared with placebo. this is a randomized placebo-controlled double-blind pilot trial. study procedures will be conducted at stanford university medical center, and standard-of-care (soc) procedures will be conducted at stanford and it's affiliated hospitals (veteran's affairs palo alto health care system and the stanford vascular surgery clinic at valley medical center). the investigators expect to enroll 128 patients. patients will be assigned to treatment groups with a 1:1 randomization in blocks of 4 at the conclusion of the av fistula creation. patients will be stratified based on fistula location (lower arm versus upper arm).

objectives: 1. to determine if vorapaxar safely improves arteriovenous (av) fistula functional maturation when administered during the maturation process compared with placebo. 2. to determine if vorapaxar safely improves av fistula patency, allowing for secondary procedures to aid in fistula maturation compared with placebo. 3. to determine if vorapaxar safely facilitates successful cannulation of av fistulas for hemodialysis compared with placebo. this is a randomized placebo-controlled double-blind pilot trial. study procedures will be conducted at stanford university medical center, and standard-of-care (soc) procedures will be conducted at stanford and it's affiliated hospitals (veteran's affairs palo alto health care system and the stanford vascular surgery clinic at valley medical center). the investigators expect to enroll 128 patients. patients will be assigned to treatment groups with a 1:1 randomization in blocks of 4 at the conclusion of the av fistula creation. patients will be stratified based on fistula location (lower arm versus upper arm). participation in this study will not affect standard care of patients with av fistulae receiving hemodialysis. the only additional treatment is administration of the study drug or placebo and additional monitoring, including one additional ultrasound, for 6 months.

Eligibility criteria:
inclusion criteria: 1. age \>18 2. receiving or planning to receive maintenance hemodialysis 3. ability to sign informed consent 4. 3 mm venous diameter within recipient vein exclusion criteria: 1. history of stroke, transient ischemic attack or intracranial hemorrhage 2. history of or high level of suspicion for, severe arterial insufficiency of the hand 3. indication or ongoing therapy with other antiplatelet agents, other than aspirin 81 mg daily 4. indication or ongoing therapy with anticoagulants, including warfarin, low molecular weight heparin, factor xa inhibitors or direct thrombin and other inhibitors.
smoke-free home study in subsidized housing

Conditions: Tobacco Dependence; Tobacco Smoking

Summary: comprehensive smoke-free policies have the potential to substantially reduce tobacco-related disparities among populations in subsidized housing. this study fills this gap by identifying approaches to increase the implementation of smoke-free policies in all types of subsidized housing by increasing the voluntary adoption of smoke-free homes and promoting access to smoking cessation services.

objectives: the investigators will build on previous studies, where a smoke-free home intervention to increase voluntary adoption of smoke-free homes in permanent supportive housing for formerly homeless adults was developed and evaluated. aim 1: to estimate the effect of our adapted smoke-free home intervention on the primary outcome of residents' voluntary adoption of smoke-free homes and the secondary outcome of biochemically-verified tobacco abstinence at 6-months follow-up. aim 2: to determine the cost of our adapted smoke-free home intervention and determine whether it is a cost-effective use of health care resources. aim 3: to evaluate variation in stakeholders' perspectives on the adapted smoke-free home intervention's adaptability, scalability and sustainability.the proposed intervention can expand access to smoke-free policies and smoking cessation services in subsidized housing, thereby reducing racial/ethnic disparities in tobacco use, tobacco exposure and chronic disease in these populations. outline: a wait-list cluster randomized controlled trial of the adapted smoke-free home intervention compared to usual care among residents from subsidized housing sites in northern california. participants from twenty-four subsidized housing sites will be randomized into intervention and waitlist control arms

Eligibility criteria:
inclusion criteria: eligible resident participants * current smokers defined as: * smoked at least 100 cigarettes in lifetime * smoked daily in the past 7 days, and at least 5 cigarettes per day, verified by expired co ≥ 5 parts per million \[ppm\] smokerlyzer co+ monitor), * smoke in their home * expect to live in the subsidized housing site for at least 12 months * age ≥ 18 years * speak chinese (cantonese or mandarin), english, spanish, or vietnamese * able to provide informed consent. exclusion criteria: * contraindication to any study-related procedures or assessment
short term effect of wearing a tie

Conditions: Musculoskeletal Disorder

Summary: the goal of this randomized controlled study is to assess the short term effect of wearing a ties on musculoskeletal system. in this scope viscoelastic properties and the mechanosensitivity of the muscles, and cervical range of motion will be measured. in addition to these measurements activity limitation due to wearing a tie and trunk mobility will be assessed.

a total of at least 54 volunteers who satisfies the eligibility criteria of the study will be recruited to the study. following to the recruitment process participants will be randomly assigned to the one of the two groups. participants in the control group will go on to their daily activities. participants in the study group will be asked to wear a tie for one working day.

Eligibility criteria:
inclusion criteria: * age of 18 to 25 years * given a signed consent * low level of physical activity * having a bmi between 18 kg/m2 and 25 kg/m2 * no pain in neck, upper and lower back (numerical pain rating scale below 3 points) exclusion criteria: * having a systemic or metabolic disease * having a mental disorder * chronic drug use * any condition that may result in muscle atrophy * musculoskeletal surgery history in last 3 months * having a cervical, thoracal or lumbar radiculopathy or myelopathy * having a whiplash syndrome or fibromyalgia * having performed any strenuous exercises within the 24 h prior to measurements

Keywords: spine pain threshold
effect of environmental temperature on vascular ultrasound vein scan measurements

Conditions: Critical Limb Ischemia

Summary: we wish to conduct two vascular ultrasound scans conducting vein measurements in two separate scanning rooms to assess if environmental temperature affects the vein diameter recorded.

vascular surgeons are guided by vascular ultrasound scans when deciding treatment plans for their patients. in critical limb threatening ischaemia with infrainguinal disease, vein bypass has the best limb salvage and long term survival rates in patients who are appropriately selected. in lower limb "vein mapping", the vein is measured to assess suitability for use as a bypass conduit with the favoured bypass conduit being autologous, ipsilateral vein of good quality and length and a size of \>3mm is considered a good conduit. the research team found one study which explored the effect of room temperature on upper limb vein measurements which was conducted in singapore. this showed an underestimation of vein size at lower temperatures. we wish to add to the literature and irish research by conducting this study at university hospital limerick in order to optimise conditions for vascular assessments and therefore facilitate clinical decision making. we aim to scan and record vein measurements on the lower limbs of vascular inpatients at university hospital limerick who are deemed suitable by the p.i. patients will have the ultrasound scan completed twice. the first room will have its temperature recorded and the vein measurements taken. the second room will be set at a higher temperature which we have defined as being 6-10 degrees greater than ambient room temperature. we will achieve this through use of a portable heater. we will compare the two recordings to assess if there is a difference in the diameter of the vein measured in the warmer room versus the standard room. the importance of this is to assess the impact of environmental factors on vascular ultrasound scan results, therefore impacting on patient outcomes by use of the most suitable bypass conduit.

Eligibility criteria:
inclusion criteria: * inpatient at university hospital limerick under the care of a vascular consultant * aged 18 years and above * deemed suitable for two vascular ultrasound scans by the p.i exclusion criteria: * those unable to give informed consent * aged under 18 years * patients with varicose veins/venous insufficiency