Kornimate/medical-research-clean huggingface dataset:
a preliminary study of model-driven individualized transcranial electrical stimulation for insomnia

Conditions: Insomnia

Summary: this study is designed to evaluate the efficacy and to explore the best individualized stimulus paradigm of transcranial electrical stimulation for insomnia patients.

twelve insomnia patients in shanghai mental health center who met the inclusion criteria will be recruited for transcranial electrical stimulation intervention. according to the patients' magnetic resonance structure and high density eeg parameters, personalized modeling was carried out to determine the specific stimulus parameter scheme.the stimulation will be performed for 2 weeks, once a night on weekdays, 10 times in total, and each stimulation will last for 20 minutes. sleep rhythms will be recorded using a wearable device. symptom assessment, magnetic resonance and high-density eeg data will be taken after the stimulation, and again 1 week after the stimulation.if the treatment is effective or clinical remission is achieved, the next cycle of stimulation will not be performed; if the treatment does not work, the patients choose to end the study or conduct modeling again to adjust the parameters and continue the next cycle of stimulation according to their wishes. for patients who choose to continue stimulation, the stimulation time of each cycle is still 2 weeks, once every night on weekdays, 10 times in total for each cycle, lasting 20 minutes each time. each patient received up to four cycles of stimulation.

Eligibility criteria:
inclusion criteria: * between 18 and 50 years old; * the patients were diagnosed as insomnia according to the diagnostic and statistical manual of mental disorders (dsm-5) and mini-international neuropsychiatric interview (m.i.n.i.) . * no psychiatric drugs were taken within 8 weeks before enrollment; ④ junior high school education or above. exclusion criteria: * past or current dsm-5 diagnoses other than insomnia, anxiety disorder and depressive disorder * severe anxiety or depression (hamd-17 \> 23 points or hama \> 30 points) * patients with obstructive sleep apnea syndrome; * participants with claustrophobic, heart pacemaker, mechanical heart valve, mechanical implant such as an aneurysm clip, hip replacement, or any other pieces of metal that have accidentally entered their body. * previous history of neurological diseases (such as epilepsy, cerebrovascular accidents, etc.) or brain trauma, brain surgery; ⑥have received ect, rtms, tes, or cognitive behavioral therapy for insomnia; ⑦any current significant medical condition. ⑧women who are pregnant or planning to become pregnant recently

Keywords: transcranial electrical stimulation
patient perception of visual quality and function

Conditions: Cataract

Summary: the purpose of this study is to evaluate the visual quality and function of pseudophakic patients.


Eligibility criteria:
inclusion criteria: * minimum 22 years of age * pseudophakic patients who have been bilaterally implanted with the same type of intraocular lenses in both eyes * ability to understand, read and write english to give consent and complete the study questionnaires * availability, willingness, and sufficient cognitive awareness to comply with examination procedures and study visits * signed informed consent and health insurance portability and accountability act (hipaa) authorization * other protocol-defined inclusion criteria might apply exclusion criteria: * any ocular pathology of clinical significance, as determined by the investigator, that may affect visual outcomes or influence subjective ocular/visual symptoms * patient is pregnant or is lactating * concurrent participation or participation within 30 days prior in any other clinical trial * other protocol-defined exclusion criteria might apply
medical nutrition therapy program and eating behavior questionnaires on gestational weight gain

Conditions: Gestational Weight Gain

Summary: type 2 diabetes mellitus (t2dm) and gestational diabetes mellitus (gdm) create complications during pregnancy, particularly in women with gestational weight gain (gwg) that falls over the recommended limit. on the other hand medical nutrition therapy (mnt) has been shown to reduce some complications in women with t2dm and gdm. the aim of this project was to assess the association of mnt consultations and eating behavior with gwg in mexican women with t2dm and gdm.

this cross-sectional study conducted at from 2013 to 2014. fifty seven patients with t2dm or gdm were invited to participate. the dependent variable was gwg and the main independent variables were mnt and eating behaviors. data were obtained from medical records or interviews. multiple linear regression models were used to assess associations.

Eligibility criteria:
inclusion criteria: * women who had given birth and with known t2dm. * women who had given birth and with gdm diagnosed during pregnancy. exclusion criteria: * women with multiple pregnancies. * women with type 1 diabetes mellitus. * women with glucose intolerance. * women with chronic diseases.

Keywords: medical nutrition therapy eating behavior type 2 diabetes mellitus gestational diabetes
prospective study of oncologic outcomes after laparoscopic modified complete mesocolic excision for non-metastatic right colon cancer [pioneer study]

Conditions: Adenocarcinoma of the Colon

Summary: this study is a multi-institutional, prospective, observational study evaluation oncologic outcomes of laparoscopic modified complete mesocolic excision (mcme) on right-sided colon cancer. the primary outcome of this study is 3 year disease-free survival. secondary outcome measures include 3 year overall survival, incidence of surgical complications, completeness of mcme, and distribution of metastatic lymph nodes.

the present study aims to evaluate the oncological outcomes of laparoscopic mcme on right-sided colon cancer. the right side of the colon was defined as the colon from cecum up to the proximal half of the transverse colon. the number of patients needs to get a 90% power is 250. patients will be enrolled at five leading centers in south korea. a complete information leaflet will give to the patients during the first consultation, which will correspond to the enrollment day. the preoperative, intraoperative, and postoperative period will be in complete accordance with the usual care of the center. the baseline demographics and conditions, as well as the perioperative items and the postoperative occurrences, will be recorded through a prior designed case report form. the follow-up encompasses 13 postoperative consultations: 1month, 3 months, after that every 3 months until 36 months. the primary outcome of this study is 3-year disease-free survival. secondary outcome measures include 3-year overall survival, the incidence of surgical complications, completeness of mcme, and distribution of metastatic lymph nodes. review of resected surgical specimens and the operative field after completion of lymph node dissection will be done based on photographs to assess the quality if surgery.

Eligibility criteria:
inclusion criteria: * 1. qualitative diagnosis: a pathological diagnosis of adenocarcinoma; the tumor located between the cecum and the right 1/2 of transverse colon * 2. patients suitable for curative surgery older than 19 years old * 3. asa grade i-iii * 4. patients without preoperative treatment * 5. informed consent exclusion criteria: * 1. informed consent refusal * 2. patients who need emergency operation; such as perforation, malignant colonic obstruction * 3. preoperative imaging examination results show: distant metastasis * 4. hereditary colon cancer * 5. history of any other malignant tumor in recent 5 years, except for cervical carcinoma in situ which has been cured, basal cell carcinoma or squamous cell carcinoma of skin; * 6. simultaneous or simultaneous multiple primary colorectal cancer * 7. women during pregnancy or breast feeding period

Keywords: adenocarcinoma in right colon mcme oncologic outcomes right-sided colon cancer
levels of the stat4 alpha and stat4 beta isoforms in pbmcs from patients with crohn's disease and ulcerative colitis

Conditions: Inflammatory Bowel Disease; Crohn's Disease; Ulcerative Colitis

Summary: the goal in these studies will be to assess the relative levels of the stat4 alpha and stat4 beta isoforms in pbmcs from patients with crohn's disease, ulcerative colitis, celiac disease or from control patients. we hypothesize that the beta to alpha ratio will be higher in patients with active disease and that there will be a correlation between the ratio and the severity of disease.


Eligibility criteria:
inclusion criteria: * children with a new diagnosis of crohn's disease and whose physician has not yet initiated corticosteroid treatment (10 subjects): * clinical diagnosis within the previous 21 days * above age 7 and younger than age 18 * signed informed consent statement and assent statement. * children with a new diagnosis of ulcerative colitis and whose physician has not yet initiated corticosteroid treatment (10 subjects): * clinical diagnosis within the previous 21 days * above age 7 and younger than age 18 * signed informed consent statement and assent statement. * children with crohn's disease whose physician has initiated infliximab treatment for the first time (10 subjects): * clinical diagnosis of crohn's disease * above age 7 and younger that age 18 * signed informed consent statement and assent statement. * children with ulcerative colitis whose physician has initiated infliximab treatment for the first time (10 subjects): * clinical diagnosis of ulcerative colitis * above age 7 and younger than age 18 * signed informed consent statement and assent statement. * healthy controls (10 subjects): * above age 7 and younger than age 18 * otherwise healthy, with no intercurrent illness as determined by a member of the study team using the eligibility checklist * controls will be gender and age (± 2 years) matched to the patient groups described above * signed informed consent statement and assent statement exclusion criteria: * unwilling to give consent for this study. * child with prior prescription and administration of infliximab

Keywords: ibd cd uc crohn's disease ulcerative colitis pediatric inflammatory markers
a phase iii study of sm-13496 (lurasidone hcl) in patients with schizophrenia

Conditions: Schizophrenia

Summary: the study evaluates the efficacy and safety of sm-13496 compared with placebo in patients with schizophrenia.


Eligibility criteria:
inclusion criteria: * patient meets dsm-iv-tr criteria for schizophrenia. * patient is aged 18 through 74 years at informed consent. * patient understands the objectives, procedures, and possible benefits and risks of the study and who provide written voluntarily consent to participate in the study exclusion criteria: * patient has a history of neuroleptic malignant syndrome, water intoxication, or paralytic ileus. * patient has parkinson's disease. * patient has a history or complication of malignancy.
the effectiveness of task-oriented training with pretend play in cp children

Conditions: Cerebral Palsy

Summary: the effectiveness of task - oriented training with pretend play on gross motor function, functional capacity and cognitive function in children with hemiplegic cerebral palsy.

purpose: this study aims to investigate the effectiveness of task-oriented training with pretend play on: gross motor function, functional capacity and cognitive function in children with hemiplegic cp. background: children with hcp experience difficulty with the motor function of the affected lower extremity. the majority of children with hemiplegia are able to walk without restrictions but more advanced gross motor skills are often affected. task-oriented training is a contemporary neurological rehabilitation technique that has the prospects of improving the quality of life of children with cp. it is a function-based, goal directed intervention that requires active involvement of the patient in a therapy that is task and context-specific, which focused on the accomplishment of functional activities and participation. pretend play is defined as play in which the child acts with intent that is representational. pretend play helps children learn how to express themselves, explore social interactions, and understand things and people within a real-world context. hypotheses: there is effect of task-oriented training with pretend play on gross motor function, functional capacity and cognitive function in children with hemiplegic cp. . ..................... research question: does task-oriented training with pretend play has an effect on gross motor function, functional capacity and cognitive function in children with hemiplegic cp?

Eligibility criteria:
inclusion criteria: * hemiplegic cp children of both genders. * their age range will be from 6 up to 8 years. * they will be have spasticity will range from 1+ and 2, spasticity will be diagnosed based on the modified ashworth scale. * they will be have gross motor function at levels ii and iii, gross motor function will be diagnosed based on gross motor function classification system expanded and revised. * they will be able to understand and follow direction. exclusion criteria: * any visual or auditory impairments. * epilepsy. * any cognitive disorder. * any fracture or orthopedic surgery in the last 6 months.
acute and chronic effects of inhaled steroids on pulmonary function in persons with spinal cord injury

Conditions: Spinal Cord Injury

Summary: individuals with chronic cervical sci are known to have a restrictive ventilatory defect due to complete or partial loss of respiratory muscle innervation which is dependent upon the level and completeness of injury \[2\]. in addition, they share many aspects of obstructive airway physiology commonly associated with asthma. in asthma, physiological responses such as decrease in baseline airway caliber, bronchodilatation following inhalation of a beta-2-adrenergic agonist or anticholinergic agent, airway hyperreactivity, are all closely related to airway inflammation. the cause of such inflammation is unclear, and may be multi-factorial and attributable to: recurrent respiratory infections due to inability to effectively clear secretions, unopposed parasymphathetic innervation, and loss of functional sympathetic innervation to the airways. therefore, the investigators propose to test for the possible involvement the above mechanisms by pharmacological intervention, and to study effects of such intervention on overall pulmonary function and indirect measures of pulmonary inflammation: levels of feno, exhaled breath condensate (ebc) inflammatory biomarker profile, pulmonary function tests, and cellular profile of the induced sputum.


Eligibility criteria:
inclusion criteria: * 18 to 65 years old; and * stable, tetraplegia c3-c8 levels (duration of injury \>1 year). exclusion criteria: * smoking, active or history of smoking during the last six months * active respiratory disease(s), such as copd, inflammatory lung disease, obstructive lung diseases, or acute respiratory infections * no known history of asthma during lifetime or recent (within 3 months) respiratory infections; * ventilator dependence; * use of medications known to affect the respiratory system, such as nizoral; * aldesleukin * oral corticosteroids (e.g., prednisone, dexamethasone) * natalizumab * drugs affecting liver enzymes that remove mometasone from your body (such as azole antifungals including itraconazole, macrolide antibiotics including erythromycin, cimetidine, rifamycins including rifabutin, st. john's wort, certain anti-seizure medicines including carbamazepine) * use of medications known to alter airway caliber; * coronary heart and/or artery disease, as indicated in the patient medical record; * hypertension, baseline blood pressure ≥ 140/90mhg; * adrenal insufficiency, as indicated in the patient medical record; * pregnancy; * lack of mental capacity to give informed consent; * history of glaucoma; * history of cataracts; and * persisting pressure ulcer, or a recently healed wound (e.g., ≤3 months since wound closure). * history of a milk protein allergy

Keywords: spinal cord injury tetraplegia pulmonary function
prochlorperazine vs imitrex for acute migraine in the emergency department

Conditions: Acute Migraine Headache

Summary: ed patients with acute migraine will be randomized to either prochlorperazine and bendaryl or imitrex. vas for pain will be monitored, along with side effects. primary outcome measure is improvement in pain scales between the groups.


Eligibility criteria:
inclusion criteria: * acute migraine headache exclusion criteria: * pregnant * hypertension * chest pain * \< 18 * allergy to any of the meds

Keywords: migraine emergency imitrex prochlorperazine acute migraine headache in the emergency department
clinical usefulness of virtual ablation guided catheter ablation of atrial fibrillation: virtual rotor mapping and catheter ablation

Conditions: Paroxysmal Atrial Fibrillation

Summary: radiofrequency catheter ablation is effective in the treatment of patients with paroxysmal atrial fibrillation. in order to reduce the recurrence rate after catheter ablation, the investigators propose to apply 'virtual' ablation on patient-specific atria by simulating 3d atrial computer model. the investigators will conduct virtual rotor mapping in the patient specific atrial model. then, the investigators will compare the clinical outcome of conventional circumferential pulmonary vein isolation and additional rotor ablation guided by virtual rotor mapping.


Eligibility criteria:
inclusion criteria: * af patient age 19\~80 * diagnosis of af patients who performed catheter ablation of atrial fibrillation due to uncontrolled pulse rate by anti-arrhythmic drug therapy. exclusion criteria: * af patients who have severe heart deformations or vascular disease. * the patient who have renal disease of egfr\<30ml/min * the patients who had been performed catheter ablation of atrial ablation and maze. * the patients who missed out to recording of 3d ct, echo and electrocardiography. * the patient have experienced major hemorrhagic complication * the patient have experienced ischemic cerebral infarction more 2 times * the patient who have risk of ischemic cerebral infarction (cha2ds2-vasc score \>5)
surgical versus non surgical management of thyroid nodule

Conditions: Thyroid Nodule

Summary: to compare between surgical (hemi thyroidectomy and total thyroidectomy) and non-surgical (medical, ethanol injection,thermal ablation and laser photo coagulation) management of simple thyroid nodule regarding: * outcome of every type of management * feasibility of minimally invasive technique in management of simple thyroid nodule in asyut university * complication of every type of management

thyroid nodules are very common in clinical practice; they are discovered by palpation in 3-7% and by ultrasound (us) in about 50% of the general population. the majority of thyroid nodules are benign and asymptomatic. the main management of benign thyroid nodules is observation and follow-up; however, a minority of them (10-15%) increase in size over time and may induce symptoms or cosmetic issues. surgical excision has been established as a treatment for symptomatic benign thyroid nodules. thyroidectomy for benign thyroid disease continues to remain controversial, as there are many conflicting data published in the literature regarding the risk of hypothyroidism and recurrent laryngeal nerve injury stratified to indications for surgery, extent of thyroid resection and surgical volume .it carries a 2-10% risk of complications and neck scarring .thyroid surgery is also costly and may not be appropriate for patients who have a high risk of surgical morbidity.therefore, image-guided nonsurgical procedures such as ethanol ablation (ea) and thermal ablation have been proposed as alternative and less invasive approaches for the management of benign symptomatic thyroid nodules .these so-called thermoablative methods induce local thermodestruction, leading to nodule shrinkage and improvement of local symptoms. monopolar radiofrequency ablation (rfa) and ea is widely used as a nonsurgical treatment usually for cystic (i.e., pure cyst) or predominantly cystic benign thyroid nodules (i.e., cystic portion \> 50%). there is another method called us-guided percutaneous laser ablation (pla) is a safe and effective therapeutic option as an alternative to surgery for benign symptomatic nodules

Eligibility criteria:
inclusion criteria: * complicated thyroid nodule exclusion criteria: * less than 18 malignant thyroid nodule
imaging airway liquid absorption in cystic fibrosis

Conditions: Cystic Fibrosis

Summary: the investigators are developing a new nuclear medicine imaging technique for measuring liquid absorption in the airways that can be applied to screen new medications being developed to treat cystic fibrosis (cf). the investigators believe that the absorption of the small molecule radiopharmaceutical indium 111-diethylenetriaminepentaacetic acid (in-dtpa) will indicate changes in liquid absorption in the airways and demonstrate whether new cf medications will be effective. in this study the investigators will further develop this technique through testing involving pediatric cf patients and healthy control subjects.

the investigators have recently developed a novel aerosol-based imaging technique to detect changes in liquid absorption in the airways - a central pathophysiological process known to be important in cystic fibrosis (cf) lung disease. this technique may provide a measure of disease severity and indication of therapeutic correction in advance of currently available outcome measures. it involves the simultaneous delivery of two radiopharmaceuticals by inhalation: one an absorbable small-molecule (indium-111 labeled diethylenetriaminepentaacetic acid; in-dtpa) and the other a non-absorbable particle (technetium 99m labeled sulfur colloid; tc-sc). the overarching hypothesis is that in-dtpa absorption provides a quantifiable, non-invasive measurement of airway liquid absorption that (a) is sensitive to cf genotype, (b) uniquely identifies basic disease phenotype and predicts disease severity, and (c) is modulated by therapeutic interventions.

Eligibility criteria:
inclusion criteria: * adult healthy control arm: * subjects 18 years old or older without a diagnosis of lung disease. * pediatric cf arm: * subjects 6-14 years with a diagnosis of cystic fibrosis as determined by sweat test or genotype * subjects who are clinically stable as determined by the pediatrician co-investigator * subjects must have a previously demonstrated ability to perform reproducible pulmonary function testing based on previous clinical visits. * females in all groups who are of child-bearing potential will need to have a negative urine pregnancy test. exclusion criteria: * adult healthy control arm: * fev1%p \< 80% of predicted * nursing mother * positive urine pregnancy test or unwilling to test * cigarette smoker (regular smoking within 6 months of study). * pediatric cf arm: * fev1%p \< 40% of predicted * nursing mother * positive urine pregnancy test for females of childbearing potential * unable or unwilling to comply with test procedure * cigarette smoker (regular smoking within 6 months of study). * subjects unable to lie recumbent without moving for the 80 minute imaging period will be excluded.

Keywords: cystic fibrosis mucociliary clearance airway surface liquid nuclear medicine
acute kidney injury in patients hospitalized with covid-19

Conditions: COVID-19; Acute Kidney Injury; Kidney Function

Summary: the kidney may be affected in coronavirus-2019 disease (covid-19). this study assessed the predictors and outcomes of acute kidney injury (aki) among individuals with covid-19.


Eligibility criteria:
inclusion criteria: * covid-19 pneumonia patients diagnosed by who criteria exclusion criteria: * patients who were younger than 18 years, * patients who had undergone renal replacement therapy (rrt) before admission, * patients whose entire stay lasted for less than 48 hours.