Kornimate/medical-research-clean huggingface dataset:
tailored interventions to prevent substance abuse

Conditions: Prevention Harmful Effects

Summary: the overarching objective of this research is to prevent substance use in early adolescents through the use of innovative interactive interventions tailored to each individual's particular risk profile for using cigarettes and alcohol. the specific aims are: (1) to test the effectiveness of the computer-based profile-based tailored interventions to keep early adolescents smoke-free compared to a comparison group; (2) to test the effectiveness of the computer-based profile-based tailored interventions to keep early adolescents from using alcohol compared to a comparison group; and (3) to replicate findings that the tailored diet and physical activity interventions will be effective in reducing these two high risk behaviors as part of the comparison condition.

research across age groups (elementary, middle and high school), populations (u.s., u.k., and israel), and substances (tobacco, alcohol and other drugs) has consistently identified four clusters of non-users who vary in their risks for substance use: (1) most protected from substance use; (2) high risk to use substances; (3) ambivalent about staying substance free; and (4) risk denial about substance use. these profiles have demonstrated both internal and external validity as well as good ability to predict future substance use and, therefore, provide an opportunity to develop a new approach to prevention. these profiles will be employed as the basis for designing two innovative computer-based interventions to prevent substance abuse by adolescents. the two new tailored interventions (smoking prevention and alcohol prevention) will be developed and tested in a school-based clinical trial. the comparison group will receive two previously developed and tested tailored health behavior interventions (diet and physical activity).

Eligibility criteria:
inclusion criteria: * 6th grade student in one of 20 participating middle schools in ri * english speaking * student assent exclusion criteria: * parent refusal for child to participate

Keywords: tobacco alcohol diet exercise
blunt fascial vs. veress needle peritoneal entry in laparoscopic gynecologic surgery

Conditions: Laparoscopic Surgery

Summary: this study aims to investigate the effect of two peritoneal entry techniques on intraoperative and post-operative outcomes among patients undergoing laparoscopic surgery with a minimally invasive gynecologic surgeon. patients will be randomized to either blunt fascial or veress needle peritoneal entry. insufflation times, failed entries, complications and post-operative pain scores will be collected. the investigators hypothesize that the blunt entry technique will be associated with shorter insufflation times and similar intraoperative and postoperative outcomes compared with the veress needle entry technique. primary objective: to evaluate the insufflation times and success upon peritoneal entry according to peritoneal entry technique. secondary objectives: to evaluate the surgical outcomes and patients pain scores according to peritoneal entry technique.

this will be a single-center, single-blinded randomized controlled trial evaluating the impact of peritoneal entry technique on insufflation times, entry failure, post-operative pain and surgical outcomes among patients undergoing laparoscopic gynecologic surgery. the investigators hypothesize that the blunt fascial entry technique will be associated with shorter insufflation times with no effect on other surgical outcomes. the study will include 2 groups corresponding to the entry techniques: blunt facial entry and veress needle entry. participants will be 1:1 allocated to each technique by block randomization. blunt fascial entry technique description: a 5 mm incision is made in the umbilicus. next, a curved kelly forceps is used to open the fascia, and, if possible, the peritoneum. the kelly forceps are then used to expand the opening to a 10 mm diameter. a 5 mm trocar is placed into the fascial hole and used to quickly insufflate the abdomen to 15 mm hg. once the abdomen is fully insufflated, a 10 mm trocar is placed using optical guidance.

Eligibility criteria:
inclusion criteria: 1. provision of signed and dated informed consent form 2. stated willingness to comply with all study procedures and availability for the duration of the study 3. 18 years of age or older 4. undergoing conventional laparoscopic surgery at cedars-sinai medical center with a surgeon in the minimally invasive gynecologic surgery division. exclusion criteria: 1. pregnancy 2. urgent/non-scheduled surgery 3. non-eligible for umbilical entry

Keywords: abdominal entry laparoscopy insufflation time postoperative pain safety
study of etacoat in patients with cataract surgery via the anterior chamber

Conditions: Cataract Surgery

Summary: this is a prospective, single center, non-comparative, 90-day follow-up, post-market clinical investigation of etacoat in patients undergoing cataract surgery. the performance is evaluated by the preservation of endothelial cells measured by specular microscopy at the follow-up visit in comparison to baseline values.


Eligibility criteria:
inclusion criteria: * patients indicated for cataract surgery via the anterior chamber * a negative urine pregnany test at visit 1 or 2 * capability to understand information about the investigation, including patients' obligations, and willingness to take part, as evidenced by signed and dated informed consent. exclusion criteria: * patient who are known to be hypersensitive to hpmc or other components of the device * patients with corneal scars or corneal dystrophies interfering with study measurements * abnormal intraocular pressure which would interfere with surgery and follow up (in opinion of the investigator) * any other condition that in the opinion of the investigator would interfere with the participation in this investigation * any person dependent on the investigator or employees of the investigation site institution or the sponsor * current or previous (within 30 days of enrollment) treatment with another investigational drug and/or medical device or participation in another clinical study * patients whose participation in clinical trials is prohibited by the austrian medical devices act
prevention of type 2 diabetes with vitamin d

Conditions: Prediabetes

Summary: the work plan will have the following s\&t components. component 1: cross-sectional study cross-sectional study will be of 1.5 years where 400 women from rural will be screened randomly for the vitamin d deficiency and its determinants including duration of sun exposure. component 2: prospective study this open-label randomized placebo-controlled trial would be done in 150 pre-diabetic women with vitamin d deficiency. the women will be recruited from cross-sectional study, out patient department and health camps and they will be followed up for 2 years. the women will be randomized into two groups; lifestyle modification counseling along with intervention with either vitamin d or placebo. the levels of vitamin d and blood glucose will be assessed periodically (every 6 months). in those having recurrent vitamin d deficiency, the course of vitamin d will be repeated. at the end of the study, incidence of t2dm in both groups will be compared.


Eligibility criteria:
inclusion criteria: * healthy women aged 20-60 years. exclusion criteria: * received vitamin d or calcium supplementation in the previous six months. * on any medication within last one month which could potentially influence insulin secretion, insulin sensitivity, vitamin d or calcium metabolism (e.g. metformin, thiazolidenediones, steroids etc.) and on any medication that activate steroid and xenobiotic receptors, and drugs used in transplantation * pregnancy and lactation at time of study * severe end organ damage or chronic diseases: renal/hepatic failure, any malignancy, major systemic illness etc. * known case of hiv infection. * known case of diabetes mellitus and other endocrine disorders.
claricore system used in transperineal prostate biopsy

Conditions: Prostate Cancer

Summary: the overall objective of this study is to acquire ultrasound images, spectral data and prostate tissue biopsy cores using the claricore system via a transperineal approach.

the overall objective of this study is to acquire ultrasound images, spectral data and prostate tissue biopsy cores using the claricore system via a transperineal approach. ultrasound images corresponding to each needle insertion and t2-weighted mr scans will be saved for the purpose of further algorithm development that will provide physicians with real time tissue classification in conjunction with location information from the ultrasound imaging.

Eligibility criteria:
inclusion criteria: 1. males per investigator assessment appropriate for transperineal prostate biopsy 2. patient scheduled for transperineal prostate biopsy based on standard of care urologic requirements to assess for tissue malignancy 3. prostate volume \> 20cc and length at least 22mm as verified by ultrasound or prostate mri prior to the procedure 4. patient must be able to provide legal consent and signs an irb (institutional review board)/ec (ethics committee) approved informed consent form to participate in the study prior to any study mandated determinations or procedure exclusion criteria: 1. any anatomical or co-morbidity contraindications to transperineal prostate biopsy or transperineal prostate mapping biopsy 2. acute painful perianal disorder (i.e. rectal abscess) 3. symptomatic, acute prostatitis 4. surgical absence of a rectum or the presence of a rectal fistula 5. patient has systemic infection or evidence of any surgical site infection (superficial or organ space), including active urinary tract infection 6. previous prostate intervention \[turp (bipolar, monopolar, laser)\] tumt, hifu, cryo, rezum, urolift\], not including previous prostate biopsy 7. current required use of blood thinning agents for medical comorbidity which prohibits the cessation of use as typically required per standard of care (soc) prior to a medical procedure; or history of a bleeding disorder (e.g. coagulopathy) 8. prior pelvic irradiation 9. actively receiving therapy for the treatment of cancer (except for patients on 5-alpha reductase inhibitors, or non-melanoma skin cancers that are managed nonsystemically) 10. actively receiving intravesical therapy or within 6 months of treatment for bladder cancer 11. patient has compromised immune system, in the opinion of the investigator 12. active inflammatory bowel disease within the last 6 months 13. any condition, or history of illness or surgery that, in the opinion of the investigator, might confound the results of the study or pose additional risks to the patient (e.g. significant cardiovascular conditions or allergies) 14. patient is not likely to comply with the protocol or follow up evaluation 15. patient is participating in a clinical trial of another investigational drug or device that may impact participation in this clinical study
the circadian rhythm of copeptin

Conditions: Circadian Rhythm; Copeptin Blood Levels

Summary: the circadian rhythm of copeptin will be examined in healthy subjects.

in 18 healthy volunteers the circadian rhythm of copeptin will be examined by withdrawing blood samples for copeptin levels every 30 minutes for 24 hours.

Eligibility criteria:
inclusion criteria: * healthy subjects exclusion criteria: * acute illness * chronic illness * pregnancy * anemia defined as hb \< 30g/l
effects of therapeutic intervention through selective functional movement assessment on pain, function, balance and gait in patients with chronic nonspecific neck pain

Conditions: Chronic Nonspecific Neck Pain

Summary: according to the order of the physical examination, the scope of the problem is narrowed down by excluding the parts of the body that do not have problems and adjusting the load related to stability. a list of problems can be created through an algorithmic approach that guesses which structures will have problems through active or passive movement. this provides an optional therapeutic intervention.


Eligibility criteria:
inclusion criteria: * adults between the ages of 18 and 65 who have experienced chronic neck pain for more than 12 weeks (blanpied et al., 2017). * those with more than moderate pain (4/10 cm) on the visual analogue scale (vas) (paksaichol et al., 2012). * those with a neck disability index (ndi) of mild disability (5/50 score) or higher (lluch et al., 2014). * those who consented to participate in this study. exclusion criteria: * patients with severe pathology such as radiation pain due to intervertebral disc herniation or neurological signs consistent with tumor, whiplash injury, cervical vertebra fracture, or nerve root compression.

Keywords: exercise neck pain chronic pain
rct of ethiodized poppyseed oil vs the second-generation non-ionic monomer contrast in hysterosalpingography of infertile patients.

Conditions: Infertility, Female

Summary: this study evaluates the difference of imaging diagnostic quality and fertility promoting effect in the diagnosis and treatment of infertility by hysterosalpingography between using ethiodized poppyseed oil and the second-generation non-ionic monomer contrast. half of participants will receive ethiodized poppyseed oil for hysterosalpingography, while the other half will receive the second-generation non-ionic monomer contrast for hysterosalpingography.


Eligibility criteria:
inclusion criteria: * aged between 21 to 39 years, female; * had spontaneous menstrual cycle; * had been trying to conceive for at least 1 year; * there was an indication for evaluation of tubal patency by means of hysterosalpingography. * understand and sign informed consent. exclusion criteria: * known endocrine disorders(e.g., the polycystic ovary syndrome, diabetes, hyperthyroidism, and hyperprolactinemia); * less than eight menstrual cycles per year; * a high risk of tubal disease (as indicated by a history of pelvic inflammatory disease, previous chlamydia infection, or known endometriosis); * hyperthyroidism; * vaginitis, acute or subacute pelvic inflammatory active phase, uterus or fallopian tube tuberculosis; * uterine or cervical bleeding; * menelipsis without excluding pregnancy; * severe heart disease and lung disease; * body temperature beyond 37.5 ℃ within 3 days before hysterosalpingography; * a total motile sperm count of \<1 million sperm per milliliter; * complications or social environment that can cause patients to fail to follow the study plan and even endanger the patient's safety.
effect of intermittent pedicle clamping on hepatocellular injury during liver surgery

Conditions: Hepatocellular Injury; Blood Loss

Summary: in order to prevent excessive blood loss during liver surgery, an intermittent pringle manoeuvre (ipm) can be applied. this implies a temporary clamping of the portal vein and hepatic artery in the hepatoduodenal ligament in order to occlude hepatic inflow. the optimal duration of the ipm is unknown. this randomized controlled trial aimed to analyse differences in hepatocellular damage after 15 minutes or 30 minutes ipm during liver surgery for primary or secondary liver tumours.

surgical procedure patients were anaesthetized using isoflurane and propofol. they routinely had an epidural catheter, urinary catheter, two peripheral venous catheters and indwelling catheters in a jugular vein and radial artery. body temperature was maintained using a bair hugger system (arizant healthcare inc. eden prairie, minnesota). the surgical procedure was performed using a subcostal bilateral incision and olivier retractors to improve exposure. after dissection of the teres hepatis ligament, the liver was mobilized. thereafter, an intra-operative ultrasound was performed to define the position of the tumour in relation to vascular and biliary structures. as ipm was not routinely applied, a patient was randomized for 15 minted ipm (15ipm) or 30 minutes ipm (30ipm) only after the surgeon had decided a complete pringle manoeuvre would be required. during 15ipm or 30ipm, the complete portal triad was clamped using a rubber sling. the time of inflow occlusion was adapted to the need according to the randomization protocol. occasionally, the left or right pedicle was ligated after protocolled ipm. five minutes reperfusion intervals were applied during which transection was stopped and cut surfaces were gently compressed to ensure hemostasis. a cavitron ultrasonic surgical aspirator (cusa system 200 macrodissector, cavitron surgical systems, stamford, connecticut) and argon beam coagulation (force gsu system, valleylab, boulder, colorado) were used for liver transection. a stapler device or clamps were used for transection of the hepatic veins. central venous pressure was maintained below 5 centimetre of water (cm h2o) during transection to reduce venous back-bleeding. after surgery, the weight of the resection specimen was recorded. perioperative care was protocolled, as described earlier.

Eligibility criteria:
inclusion criteria: * patients \> 18 years of age and \< 100 years of age * primary or secondary liver tumours requiring liver surgery exclusion criteria: * pre-existent liver disease (e.g. inflammatory liver disease, cirrhosis, inborn errors of metabolism) * cholangiocarcinoma requiring biliary tract reconstruction during surgery * steroid hormone medication * tumours deemed irresectable during liver surgery * laparoscopic liver surgery

Keywords: liver surgery pringle manoeuvre hepatocellular damage surgical complications patients requiring liver surgery
effect of modified playground environment on health, particularly immune system

Conditions: Atopic Disorders; Immune System Diseases

Summary: children were exposed to biodiverse material or non-diverse material in sand pits. the two arms were compared. immune response and bacterial markers were followed.

children of age 3-5 were randomly divided into two groups (arms). one received guidance and biodiverse material for 20 minutes each day for two weeks. the other received the a similar material and guidance but the microbial community in the material was poor in diversity. bacterial community changes and immune system markers were analyzed and compared between the two arms. potential changes in interleukin 10 was the primary outcome.

Eligibility criteria:
inclusion criteria: * healthy * born in finland * spends daily (5 d a week) several hours in one of the daycares in which the trial was performed exclusion criteria: * medication affecting immune system function * medication affecting microbiota * cancer * immune deficiency * living on a farm * not born in finland

Keywords: biodiversity intervention sand box guidance
lullaby and classic music's effect on vital findings and comfort

Conditions: Nutrition Disorder, Infant; Music; Preterm; Vital Signs

Summary: in the study, lullabies and classical music played to preterm babies during orogastric tube feeding; it will be tried to determine the effect on cerebral oxygenation level, vital signs and comfort levels.

in the literature, there are many studies on prematurity pain and its relief. although the vital signs and comfort levels of infants were examined in many applications for infants hospitalized in the neonatal intensive care unit, no study was found in which the cerebral oxygenation levels of infants were evaluated by nirs by listening to lullabies and classical music to premature infants. there is no study in the literature examining cerebral oxygenation, vital signs and comfort parameters together during orogastric tube feeding, which is frequently used in preterm infants. for this reason, in this study, lullabies and classical music played to preterm babies during orogastric tube feeding; it will be tried to determine the effect on cerebral oxygenation level, vital signs and comfort levels. it is thought that the study will present new data to the literature and will lead many researches.

Eligibility criteria:
inclusion criteria: * being at 28-34 weeks of gestation, * stability (in terms of cerebral oxygenation, pain and vital signs) during enrollment, * not having any additional diagnosis other than the diagnosis of prematurity, * indication of bolus feeding with an orogastric tube, exclusion criteria: * congenital anomaly in the baby * diagnosed hearing impairment in the baby * having a history of an invasive procedure (such as a surgical operation) that will disrupt the baby's long-term comfort and cause pain * the baby is receiving oxygen therapy or the baby is on mechanical ventilation * any history of disease affecting cerebral oxygenation (such as intraventricular hemorrhage, neonatal convulsions).

Keywords: preterm babies cerebral oxygenation lullabies classical music
evaluate the potential of montelukast to prevent nasal symptomatology during colds

Conditions: Upper Respiratory Infection

Summary: assesses the efficacy of treatment with montelukast 10 mg po qd x 5 days versus placebo for the treatment of viral-induced upper respiratory infection in healthy adults aged 18-50 years.

this is a randomized double-blinded placebo controlled trial to assess the efficacy of treatment with montelukast 10 mg po qd x 5 days versus placebo for the treatment of viral-induced upper respiratory infection in healthy adults aged 18-50 years. all subjects complete daily assessments of cold symptoms, nasal clearance rates and secretion rates during each day of the study. phlebotomy is performed once for the determination of cytokine genotyping and allergy skin testing is performed once for the assessment of atopy.

Eligibility criteria:
inclusion criteria: * adults 18 to 50 years of age. * male or female, who are not pregnant or lactating. * common cold symptoms for less than 24 hours. * at least 2 of the following 9 symptoms: cough, headache, hoarseness, muscle ache, nasal drainage, nasal congestion, scratch throat, sneezing and malaise. exclusion criteria: * investigational medication in past 30 days. * known hypersensitivity to any ingredients in study medication. * history of asthma or other chronic diseases. * females of childbearing potential who are not using a medically acceptable form of birth control. * patients with nasal ulcers within the past 1 month, nasal surgery within the past 6 months, nasal trauma within the past 2 months or presence of nasal polyps or nasal deformities causing significant nasal obstruction. * females with a positive urinary hcg test. * patients with a positive rapid antigen test for streptococcal infection. * common cold symptoms for more than 24 hours. * patients who are users of illicit drugs. * patients who are on rifampin or phenobarbital.

Keywords: cold upper respiratory infection