Kornimate/medical-research-clean huggingface dataset:
collagen-targeted positron emission tomography (pet) imaging for assessment of egcg effect

Conditions: Idiopathic Pulmonary Fibrosis

Summary: the primary purpose of this substudy is to determine if collagen-targeted pet using the type 1 collagen-targeted pet probe, gallium-68 (68ga)-labeled collagen binding probe 8 (cbp8) can inform as to drug effect of egcg and assist in dose selection.

this is an optional sub-study of the phase i study: "dose ranging study of oral epigallocatechin-3-gallate (egcg) given daily for 12 weeks to patients with idiopathic pulmonary fibrosis (ipf) evaluating safety, pharmacokinetic (pk) interactions with standard of care drugs, and biomarkers of drug effect." up to twenty-two participants participating in the aforementioned study will be enrolled into this sub-study. this substudy will be conducted at a select number of sites with capabilities for performing \[68ga\]cbp8 pet. eligible participants who consent to the substudy will undergo \[68ga\]cbp8 pet-ct or \[68ga\]cbp8 pet-mri at two time points. participants will undergo 68ga-cbp8 pet within 7 days prior to randomization and then again within 7 days prior to day 84 of the phase i study. the hypothesis is that \[68ga\]cbp8 pet will detect decreased collagen deposition in individuals treated with egcg compared to placebo.

Eligibility criteria:
inclusion criteria: 1. enrolled in and eligible (based on screening procedures - visit 1) for the main egcg phase 1 study, "dose ranging study of oral epigallocatechin-3-gallate (egcg) given daily for 12 weeks to patients with idiopathic pulmonary fibrosis (ipf) evaluating safety, pk interactions with standard of care drugs, and biomarkers of drug effect 2. signed informed consent exclusion criteria: 1. pregnant or breastfeeding (a negative quantitative serum human chorionic gonadotropin (hcg) pregnancy test is required for females having child-bearing potential before the participant can participate)\* 2. research-related radiation exposure exceeds 50 millisievert (msv) in the prior 12 months 3. determined by the investigator to be clinically unsuitable for the study additional exclusion criteria for participants undergoing pet-mri: 1. electrical implants such as cardiac pacemaker, defibrillator, or perfusion pump 2. metallic or electric implants contraindicated for magnetic resonance-pet (mr-pet) scanning 3. claustrophobic reactions 4. estimated glomerular filtration rate (egfr) of less than 30 ml/min/1.73 m2 within the prior 30 days 5. known allergy to gadolinium * women of childbearing potential (wcbp) are defined as a sexually mature woman not surgically sterilized or not post-menopausal for at least 24 consecutive months if \< 55 years or 12 months if ≥ 55 years.
documentation of humira in psoriasis patients in routine clinical practice

Conditions: Moderate to Severe Plaque Psoriasis

Summary: safety and effectiveness of adalimumab (humira) in psoriasis patients in routine clinical practice.

postmarketing observational study to evaluate the work productivity, safety and efficacy of humira for the treatment of moderate to severe plaque psoriasis in daily clinical practice. the primary objectives of the pmos are to explore changes in health related care utilization data by the evaluation of: * the number of missed working days * the number of visits to doctor's office * the number and duration of hospitalizations * work ability to assess efficacy for different subgroups by * the number of patients achieving a pasi 75 response to evaluate safety by * the documentation and analysis of adverse events for all patients and subgroups with concomitant diseases secondary objectives include the exploration of changes in quality of life measurements, of the influence of age, gender and duration of disease

Eligibility criteria:
inclusion criteria: - moderate to severe plaque psoriasis in adults with no response to other systemic therapy (e.g. cyclosporine, methotrexate or puva (photochemical therapy)) or patients with a contraindication or hypersensitivity to such a therapy exclusion criteria: - hypersensitivity against the drug or one of the other ingredients; active tuberculosis or other severe infections (e.g. sepsis and opportunistic infections); moderate to severe cardiac insufficiency

Keywords: moderate to severe plaque psoriasis humira safety efficacy work productivity
a collaborative care program to improve depression treatment in cardiac patients

Conditions: Coronary Artery Disease; Congestive Heart Failure; Arrhythmia; Depression

Summary: depression in cardiac patients is common, persistent, and deadly. however, the vast majority of cardiac patients with depression go unrecognized and untreated, despite the existence of treatments that clearly improve depressive symptoms and may favorably impact survival. our research group and others have found that depression recognition and treatment appears particularly limited among patients with acute cardiac illness, though this population may be the most vulnerable to the deleterious effects of depression. we propose a project, building on successful collaborative care depression management programs in outpatient settings, to address this important issue. the specific hypotheses behind the proposed research are that a collaborative care depression management program can be successfully adapted to inpatient cardiac units, and that such a program will lead to greater rates of adequate depression treatment and improvements in secondary outcomes. the following specific aims capture the stepwise goals of this program: 1. to determine whether a collaborative care depression management program ('enhanced care') leads to significantly increased rates of adequate depression treatment compared to usual care (screening and feedback) (primary aim). 2. to assess whether this enhanced care program has a lasting impact on adequate depression treatment, depressive symptoms, health-related quality of life, and adherence to medical recommendations at 6 weeks, 12 weeks, and 6 months, compared to usual care.


Eligibility criteria:
inclusion criteria: * inpatient admission for cardiac diagnosis * positive depression evaluation (phq-2\>2, phq-9\>9) * ability to provide informed consent exclusion criteria: * active suicidal ideation * bipolar disorder, psychotic disorder, active substance use disorder

Keywords: collaborative care
heartbeet clinic pilot trial

Conditions: Hyperlipidemia; Hypertension

Summary: the goal of the current study is to conduct a pilot randomized controlled trial comparing the heartbeet clinic, a 16-week lifestyle medicine program with virtual, small-group coaching, to a self-paced, online education program. in this pilot study, the primary goals will be to assess acceptability and feasibility of the study and intervention procedures to prepare for a larger efficacy trial.

individuals randomized to the 16-week heartbeet clinic lifestyle medicine intervention will complete two in-person group visits, one at the beginning and one at the end of the program. they will also attend group coaching sessions that will be held virtually, using an online coaching platform that will house the self-paced course, intervention materials, and schedule for the coaching and live events. individuals in this group will be asked to attend 12 group coaching sessions with a health coach, 6 skills sessions to enhance behavior change skills with a health coach, and 6 deep dives with subject matter experts. these sessions will require 1-2 hours of participation per week. in addition, participants will be asked to work through the self-paced course and workbook activities on their own between sessions. individuals randomized to the self-paced education group will have access to the virtual coaching platform for the self-paced course and workbook. they will receive email reminders to work through the workbook activities. they will not have contact with the study clinician or health coach except to troubleshoot technical issues.

Eligibility criteria:
inclusion criteria: * have at least one cardiovascular risk factor, including: a) high cholesterol, as defined as diagnosis of hyperlipidemia and/or most recent total cholesterol \> 200 or b) hypertension (as defined by a diagnosis of hypertension and/or active antihypertensive medication prescription) and/or bmi \> 27 * identify as a healthpartners patient, including having an outpatient encounter with a healthpartners or park nicollet clinician in the prior year * be willing to pay for copays/charges for group medical visit and labs drawn as part of usual care if not fully covered by insurance * stated willingness to comply with all study procedures and availability for the duration of the study * willingness to maintain current doses of statin, anti-obesity medication, and/or antihypertensive medication during the study * willingness and ability to attend weekly group coaching sessions for 16 weeks at ≥ 1 scheduled group coaching time * access to necessary resources for participating in a technology-based intervention (i.e., computer, smartphone, internet access exclusion criteria: * concurrent participation in another treatment or intervention study * history of coronary artery, cerebrovascular or peripheral arterial disease including myocardial infarction, unstable angina, revascularization, stroke/tia, carotid intervention, claudication, or congestive heart failure * existing diagnosis of dementia and/or other cognitive impairment that would be a barrier to participation

Keywords: cardiovascular health
compartment psoas block efficacy and safety

Conditions: Femur Fracture

Summary: a randomized controlled trial to assess the efficacy and safety of the prolonged compartment psoas block for analgesia and anesthesia for femur surgery in the elderly

a randomized controlled trial was conducted from january 2018 to august 2019 at the into-sana medical center (odessa, ukraine). the study design was approved by the ethical committee at bogomolets national medical university. patients who planned osteosynthesis of the proximal femur and who met the inclusion criteria were randomized to 3 study groupsthe aim of our study was to compare the effectiveness and safety of different techniques of perioperative anaesthesia and anaesthesia in patients with fractures of the proximal femur: general anaesthesia and systemic analgesia, neuraxial (spinal) anaesthesia, compartment psoas block in combination with a sciatic nerve block. patients in group 1 underwent catheterization of the lumbar plexus from the posterior access on admission to the hospital and began analgesia with bupivacaine 0.125% 6-8 ml / h. intraoperative anesthesia was provided with a bupivacaine bolus of 0.5% 200 mg in a lumbar catheter and a sciatic nerve block with 1.5% 450 mg of lidocaine. postoperative analgesia was provided with prolonged lumbar plexus block with bupivacaine 0.125% 6-8 ml / h. patients in group 2 underwent intraoperative spinal anaesthesia at the level of l3-l4 with hyperbaric bupivacaine 10-15 mg. patients in groups 1 - 2 receive intraoperative sedation with propofol 1% with a target level of sedation rass from 0 to -2. group 3 patients underwent general sevoflurane inhalation anaesthesia with fentanyl infusion for analgesia. all patients received paracetamol 3g/day and dexketoprofen 75 mg/day during hospitalization. on-demand, nalbuphine 5 mg sc was used for analgesia.

Eligibility criteria:
inclusion criteria: -proximal femur fracture exclusion criteria: * pregnancy and lactation * history of opiate addiction * traumatic brain injury * acute cerebrovascular accident * chronic heart failure (new york heart association functional classification, nyha, class iii-iv) * respiratory failure * renal failure with decreased creatinine clearance less than 30 ml / min / 1.73 m2 * hepatic insufficiency class c according to child-pugh).

Keywords: сompartment psoas block, femur fracture.
hand dominance in fibromyalgia

Conditions: Fibromyalgia

Summary: evaluating laterality changes in different psychiatric and neurodevelopmental diseases has recently been one of the popular perspectives of laterality studies. there are studies reporting changes in functional and structural hemispheric asymmetries in some neurodevelopmental and psychiatric diseases, and thus relations with atypical lateralization patterns or handedness. there is no study in the literature evaluating brain lateralization or handedness in fibromyalgia. the aim of our study is to evaluate the relationship between handedness, which is an indicator of brain lateralization, and fibromyalgia disease severity and functional outcomes related to fibromyalgia in patients with fibromyalgia. this cross-sectional study included 40 fibromyalgia patients aged 20-50 years, meeting the american college of rheumatology 2016 fibromyalgia diagnostic criteria, and 40 healthy volunteers in the same age range as the control group. information about the age, gender, height, weight, and comorbidities of the participants included in the study were recorded. in addition, information about the duration of fibromyalgia diagnosis and pharmacological and non-pharmacological treatments for fibromyalgia were also recorded in the patient group. handgrip strengths with jamar-type hand dynamometer, tip pinch strengths with pinch meter, and hand dexterities with the nine-hole peg test were evaluated for both hands of all participants. the edinburgh handedness inventory, beck depression inventory, and beck anxiety inventory were administered to all participants. in addition, the american college of rheumatology 2016 fibromyalgia diagnostic criteria was questioned in the patient group, and the revised fibromyalgia impact questionnaire was applied.


Eligibility criteria:
inclusion criteria: * this study included 40 fibromyalgia patients aged 20-50 years, meeting the american college of rheumatology (acr) 2016 fibromyalgia diagnostic criteria. exclusion criteria: * exclusion criteria were defined as being younger than 20 years of age, older than 50 years of age, having systemic, inflammatory, degenerative, and neurological diseases that may lead to loss of hand and finger grip strength and dexterity, and a history of hand surgery or trauma in the last three months.
effectiveness of heart rate variability biofeedback training versus a meditation program in reducing stress levels in university undergraduate students.

Conditions: Stress; Anxiety State

Summary: the objective of this trial is to evaluate the efficacy of a heart rate variability biofeedback training protocol, compared to a guided meditation program and a control group, in reducing stress and anxiety levels among university undergraduate students.


Eligibility criteria:
inclusion criteria: 1. second- and third-year students of the physiotherapy degree at various universities in the province of seville. 2. enrolled in all courses for the academic year. 3. enrolled in the courses for the first or second time. exclusion criteria: 1. having a job in addition to academic responsibilities. 2. having a dependent family member under their care. 3. diagnosed with any mental health issues. 4. diagnosed with severe metabolic, cardiovascular, or respiratory conditions, or cancer. 5. simultaneously pursuing another degree or a dual degree program.
value of 3d printing for comprehension of liver surgical anatomy

Conditions: Liver Cancer

Summary: to our knowledge, it has not been analyze whether 3d printed liver model would improve the perception of a given liver tumor or the precision of operation planning in liver surgery. we design this prospective controlled trial to test whether the 3d-printed patient specific liver model could be more informative than standard mdct (multi-row detector computed tomography ) and 3d visualization system in predicting the surgical anatomy of liver.

the primary objective was to investigate whether 3d printing can improve localization of hepatic pathology. the secondary objective was to investigate whether 3d printing can improve the precision of surgical proposal. the dataset of patients were prepared and stratified into mdct, 3d visualization system and 3d printed liver model groups. the process started from mdct scan image acquisition and moved through image segmentation and 3d rendering to end up with 3d printing. surgical residents were assigned to three different groups to study different modes of patients' data. residents were ask to state the liver segment in which the tumor resides and make a minimal resection proposal, including the tumor, the safety margin (1cm) and the dependent liver tissue. residents were recommended to proceed in a classic way by resecting the whole liver segment. the time spent by each resident was also recorded in order to assess the quickness of comprehension and information transfer of the three different modes of presentation.

Eligibility criteria:
inclusion criteria: * surgical residents * must had experiences with mdct and 3d visualization system exclusion criteria: * non surgical residents * no experiences with mdct or 3d visualization system
using multimedia approaches to communicate probabilities in patient decision aids for low-literacy populations: randomized trial

Conditions: Colorectal Cancer

Summary: the goal of this research study is to compare how people who are 45-75 years old respond to 3 different versions of a program about screening tests for colorectal cancer. researchers want to use this study as part of a long-term project to learn the best ways to communicate health information to patients.

if you agree to take part in this study, you will be randomly assigned (as in a roll of dice) to 1 of 3 study groups. neither you nor the study staff will be able to choose which group you will be in: * if you are in group 1, you will read a booklet about colorectal cancer screening tests. while reading the booklet, you will also listen to an audio cd that will narrate the booklet. * if you are in group 2, you will watch a video with non-moving images about colorectal cancer screening tests on an ipad. * if you are in group 3, you will watch a video with animated images about colorectal cancer screening tests on an ipad. you will complete questionnaires before and after viewing the program that will contain questions about: * your age and what language you speak * your math and reading comprehension * your knowledge of colorectal cancer and colorectal cancer screening * your thoughts about colorectal cancer screening * your opinions about this study, and * how well you understand the booklet/video you view as part of this study it will take about 1 hour to complete all the questionnaires. in total, the study will take about 1 ½ to 2 hours to complete. after you have completed the questionnaires, your participation in the study will be over. this is an investigational study. up to 201 people will take part in this multicenter study. up to 67 will be enrolled at md anderson.

Eligibility criteria:
inclusion criteria: 1. men and women 45 to 75 years of age. 2. participant must speak english. exclusion criteria: 1) self-reported diagnosis of colon cancer.

Keywords: colorectal cancer colorectal cancer screening multimedia booklet pamphlet audio cd video with animated images video with non-moving images questionnaires surveys
inhaled nitric oxide (ino) in hypoxic respiratory failure

Conditions: Hypoxic Respiratory Failure With Pulmonary Hypertension

Summary: this phase 3, double-blind, randomized, placebo controlled, multicenter study is to confirm the efficacy of inhaled nitric oxide for the management of hypoxic respiratory failure associated with pulmonary hypertension in preterm infants. study subjects will be administered either inhaled nitric oxide or placebo to determine if there is a change in oxygenation.

this trial will be a multi-center, double blind, placebo-controlled, randomized clinical trial. all mothers identified with prolonged rupture of membranes and/or oligohydramnios, and all inborn infants \< 30 weeks gestational age (ga) at birth will be screened for enrollment. infants who meet all inclusion and exclusion criteria within the first 48 hours after birth will be randomized to either inhaled no starting at 20 ppm, or matched placebo, delivered by means of a blinded inovent® delivery device. randomization will be stratified by center and treatment will be assigned using an interactive voice or web-based response system (ivrs). all infants will receive up to 14 days of therapy, following a dose reduction schedule. the primary outcome measure will be change in oxygenation at 1 hour after start of therapy. in order to determine the effects of ino therapy on survival and need for mechanical ventilation, cross-over will not be allowed. this clinical trial will attempt to demonstrate if pre-term infants may benefit from treatment with nitric oxide for inhalation. a multi-center study is necessary to recruit an appropriate number of subjects, and to reflect the variability of standard practice across the different participating centers. all treatment assignments are blinded in order to minimize the risk of bias in treatment and data collection. in addition, a concurrent placebo group has been chosen as the most appropriate control group since there may be temporal, institutional and national variations in average outcomes. methemoglobin levels will be measured locally and will collected in a blinded manner.

Eligibility criteria:
inclusion criteria: preterm infants who: * are in-born at \< 30 weeks gestational age * weigh 500-1250 grams * have hypoxic respiratory failure requiring mechanical ventilation with fio2 \> 0.8 to maintain sao2 ≥ 85% in the first 48 hours after birth after use of exogenous surfactant * have minimal parenchymal lung disease by chest x ray exclusion criteria: preterm infants who: * have ten minute apgar score \< 5 * have life-threatening anomalies (cardiac, thoracic, chromosomal) or congenital diaphragmatic hernia with lung hypoplasia, or any child who will not receive complete intensive care * have bilateral grade iv intraventricular hemorrhage (ivh) * are dependent on right to left shunting to maintain the systemic circulation * have received prior ino therapy * have had treatment with investigational medications

Keywords: hypoxic respiratory failure (hrf), pulmonary hypertension
results of suprachoroidal steroids injections in two chorioretinal diseases

Conditions: Central Serous Chorioretinopathy; Irvine-Gass Syndrome; Pars Planitis; Cystoid Macular Edema

Summary: suprachoroidal injection is a safe way for intraocular drug delivery. it was used to treat various retinal conditions.

suprachoroidal triamcinolone acetonide injection is used to treat various retinal diseases, higher concentration of the injected material is found when the suprachoroidal space is used as an intraocular delivery pathway when compared to the conventional intravitreal pathway.

Eligibility criteria:
inclusion criteria: * patients diagnosed as central serous chorioretinopathy and patients with cystoid macular edema due to irvine-gass syndrome after cataract surgery. exclusion criteria: * other retinal diseases that may affect cmt and final visual outcome. * patients with dense corneal opacity.

Keywords: central serous chorioretinopathy cystoid macular edema