Kornimate/medical-research-clean huggingface dataset:
church-based intervention to improve physical function

Conditions: Physical Function; Multiple Chronic Conditions

Summary: this is a 12-month multi-level behavioral cluster randomized trial testing a church-based intervention to improve physical function (pf) in americans with pf limitations.


Eligibility criteria:
inclusion criteria: churches (community-level): * membership of 300 or more adults * located in cook, lake, dupage, will, mchenry, kane, or kendall counties participants (individual-level): * age 40 or older * have mobility limitations (defined as sppb score of ≤9) * ambulatory, defined as able to get out of a chair and walk without assistance without using a straight cane * able to speak and read english * attend recruitment church; and * safe to begin an exercise program, which will be determined using the exercise assessment and screening for you (easy) tool. exclusion criteria: participants (individual-level): * severe cognitive impairment, defined as five or more errors on the short-portable mental status questionnaire * unable to consistently attend group classes at a scheduled time due to lack of reliable transportation, schedule conflicts, travel, plans to relocate, upcoming surgery, etc. * participating in a medically supervised rehabilitation program such as cardiac rehab * inpatient treatment for a psychiatric condition within the past 6 months, or currently receiving treatment for schizophrenia or other serious psychiatric illness * contraindications to exercise determined using the easy/healthcare follow-up * congestive heart failure new york health association (nyha) class i or higher; unstable angina; heart attack or stroke within past 6 months * visual or hearing impairment.
construct validity and reliability scale

Conditions: Cerebral Palsy

Summary: the aim of the study was to determine construct validity, discriminant validity and intra- and interrater reliability of the selective control assessment of the lower extremity ( scale).


Eligibility criteria:
inclusion criteria: * diagnosis of spastic cerebral palsy, * age between 4 and 18 years, * ability to follow simple instructions. * ability to walk (gmfcs levels i-iv), exclusion criteria: * unstable situation regarding their tonus-regulating medications * orthopedic intervention or surgical correction within the last year, * botulinum toxin injection within the last 6 months

Keywords: lower limb
bioavailability of gdc-0134 and the effect of food and proton pump inhibitor on pharmacokinetics of gdc-0134 in healthy female participants

Conditions: Amyotrophic Lateral Sclerosis

Summary: this study will evaluate the pharmacokinetics and safety of gdc-0134 in healthy female volunteers of non-childbearing potential. the first part of the study will compare the bioavailability of a prototype capsule of gdc-0134 relative to an existing gdc-0134 reference capsule (periods 1 and 2). the second part of the study will assess the effect of gdc-0134-in-applesauce preparation under fasting conditions, the effect of low and high fat foods as well as the effect of elevated stomach ph via pre-treatment with rabeprazole, a proton pump inhibitor (ppi), under fasted and high-fat meal conditions (periods 3 and 4).


Eligibility criteria:
inclusion criteria: * healthy female participants between 30 and 65 years of age, inclusive; * within body mass index range 18.0 to 35.0 kilograms per square meter (kg/m\^2), inclusive; * female participants will be of non-childbearing potential; * in good health, determined by no clinically significant findings from medical history, 12-lead echocardiogram (ecg), and vital signs; * clinical laboratory evaluations within the reference range for the test laboratory, unless deemed not clinically significant by the investigator; * normal ophthalmology assessment. exclusion criteria: * males and females of childbearing potential; * significant history or clinical manifestation of any significant metabolic, allergic, dermatological, hepatic, renal, hematological, pulmonary, cardiovascular, gastrointestinal (gi), neurological, or psychiatric disorder (as determined by the investigator; * history of significant hypersensitivity, intolerance, or allergy to any drug compound, food, or other substance, unless approved by the investigator; * history of stomach or intestinal surgery or resection that would potentially alter absorption and/or excretion of orally administered drugs; * history of gi bleeding or gi ulcers; * any personal or family history of bleeding disorders, and any personal use of drugs known to affect blood clotting within 30 days of dosing; * any acute or chronic medical condition or abnormality in clinical laboratory tests that, in the investigator's judgment, precludes the subject's safe participation in and completion of the study.
synovial fluid analysis of intraarticular elbow fracture

Conditions: Elbow Fracture; Joint Contracture

Summary: the objective of this study is to obtain and compare bilateral elbow joint synovial fluid from patients with unilateral intraarticular elbow fracture and a contralateral healthy appearing elbow joint. the synovial fluid samples will undergo several forms of analysis for metabolites and proteins. matched-pair statistical analysis will be performed to determine the metabolites and proteins that may play the greatest role in development of joint contracture.


Eligibility criteria:
inclusion criteria: * 18 years and older * intraarticular elbow fracture (humerus, radial head and/or ulna fracture) exclusion criteria: * age \<18 years * open elbow fracture * bilateral elbow fractures * patients with history of osteomyelitis of elbow * inflammatory arthropathy (ie. rheumatoid arthritis) * prior surgery on fractured elbow
observational study to assess oxygen saturation predictive power related to intradialytic acute hypotension

Conditions: Acute Intradialytic Hypotension

Summary: the aim of the present work was to analyze the short-term variability of so2 during hemodialysis in sessions with and without hypotension to correlate the so2 variability to hemodynamic instability.

during the last 40 years a lot has been achieved in dialysis regarding both monitors safety and membranes overall performances anyway, intradialytic symptoms still remain a major concern for nephrologists: in particular, hypotension is the most frequent \[1\]. intradialytic hemodynamic monitoring systems have been developed to have continuous surveillance of the main hemodynamic variables (heart rate, body temperature, blood pressure itself, cardiac output, ecc...). in a second moment, the further evolution was towards the retroactive control systems, to force some of the variables involved in the genesis of the hemodynamic stability, along a pre-determined, ideal, trend. in this view, various bio-feedback mechanisms have been proposes along the years, for example, to tackle hypovolemia-related hypotension. their scientific rationale is the control of either blood volume or directly natremia, in order to pilot plasma refilling towards the vascular compartment \[2\]. despite the great achievements obtained, the forecasting of acute hypotension during hemodialysis still remains a complex problem, likely involving more than one variable. so2 can be considered an indirect expression of the hemodynamic stability. moreover, in dialysis, it has always been regarded as a bio-compatibility marker for membranes \[3\]. nowadays, so2 changes during dialysis are easy to measure with a fully, non-invasive sensor assembled on the arterial line. we planned this study to analyze on a large number of sessions the short-term variability of so2 during hemodialysis in relationship with hemodynamic tolerance.

Eligibility criteria:
inclusion criteria: * dialysis vintage \> 6 months * well functioning arterovenous fistula or central venous catheter * thrice weekly hd treatment schedule * acute hypotensions in the last month before study start \> 20% of sessions exclusion criteria: * mental illness * life expectancy \< 6 months * any profiling and/or biofeedback strategies routinely prescribed

Keywords: dialysis monitoring cardiovascular stability biosignals
effectiveness comparison of three supplementary foods in the treatment of moderate acute malnutrition

Conditions: Malnutrition

Summary: the purpose of this study is to compare the recovery rates of moderately malnourished malawian children treated with either milk-enriched corn/soy blend, soy/peanut fortified spread or a commercially produced ready-to-use therapy food.


Eligibility criteria:
inclusion criteria: * whz \ -3 without bilateral pedal edema * reside within 7 kilometers of study site. exclusion criteria: * not permanent resident in vicinity of study site. * severe chronic illness such as cerebral palsy. * history of peanut allergy or anaphylaxis resulting from any food. * receiving other supplementary food or participating in other research.

Keywords: malnutrition supplemental food csb++ supplementary plumpy
effects of pulsed electromagnetic field on autonomic function in patients with chronic musculoskeletal pain

Conditions: Chronic Musculo-skeletal Pain

Summary: previously it has been demonstrated that exposing the heart to electromagnetic field during exercise stress test improves the recovery following the stress test. this is explained by the effect of the electromagnetic field on the sympathetic activity of the heart. in the present study we would like to further investigate the effects of electromagnetic field on autonomic nervous system function in patients with chronic musculoskeletal pain that usually have high sympathetic activity. each patient will be exposed to 20 minutes of electromagnetic field during which the autonomic nervous system function will be measured. in addition, patient tolerability to the exposed magnetic field will be investigated. we assume that short exposure to electromagnetic field would result in decreased sympathetic activity and therefore, on the long run, could be suggested as a therapeutic tool for such patients.

adult patients suffering from chronic muscoloskeletal pain will be recruited to this study during their weekly visits to the department for complementary medicine at sheba medical center. patient will be exposed to 20 minutes of weak intensity and low frequency electromagnetic field while seated, during which heart rate variability measures will be recorded. in addition, patient tolerability to the exposed electromagnetic field will be investigated, including vas score (pain score). this is a double blind placebo-control study by which neither the patients nor the physicians know which treatment is given to the patients. the study code will be open only at the end of the trial.

Eligibility criteria:
inclusion criteria: * chronic musculoskeletal pain exclusion criteria: * implantable defibrillator * implantable pacemaker * active cancer * pregnancy

Keywords: electromagnetic field vas score heart rate variability
to evaluate eye installation-tear free

Conditions: Sunscreening Agents

Summary: the primary objective of this study was to compare the human eye stinging potential of experimental formulas of sun care products \[sun protection factor (spf) 50 y49 091, spf 50 x15 158, spf 50 x15 160 and spf 50 x57 162 compared to an industry standard shampoo mixture.


Eligibility criteria:
inclusion criteria: * healthy males or females, 18 to 60 years with no medical conditions of the eyes as determined by the subject's medical history and confirmed by an ophthalmologist * subjects not under any doctor's care for ocular or peri orbital diseases * the subject will refrain from using contact lenses, any topical facial products, any eye drops, false eyelashes, make up, over the counter products, or cosmetics on their eyes, eyelids, eyelashes, or the periorbital areas of the face during the study.

Keywords: eye stinging potential
a prospective multicentre study evaluating the outcomes of the abdominal wall dehiscence repair using posterior component separation with transversus abdominis muscle release reinforced by a retro-muscular mesh - filling a step

Conditions: Abdominal Wall Defect

Summary: purpose: this study determined the incidence of burst abdomen recurrent (bar), incisional hernia(ih), and surgical site occurrence (sso) following burst abdomen surgical treatment after abdominal midline incisions using a posterior component separation(cs) technique with transversus abdominis muscle release (tar) reinforced by retro-muscular mesh technique. methods: between june 2014 and april 2018, 202 patients with grade ia ba (björck's first classification) were treated in a prospective multiple-center cohort study.

this study determined the incidence of burst abdomen recurrent (bar), incisional hernia(ih), and surgical site occurrence (sso) following burst abdomen surgical treatment after abdominal midline incisions using a posterior component separation(cs) technique with transversus abdominis muscle release (tar) reinforced by retro-muscular mesh technique. methods: between june 2014 and april 2018, 202 patients with grade ia ba (björck's first classification) were treated in a prospective multiple-center cohort study.

Eligibility criteria:
inclusion criteria: * ba grade ia according to björck's initial classification following midline laparotomy from various departments, * ≥ 18 years * both sex * emergency or elective surgery exclusion criteria: * ba grade 1b,2,3, and 4 according to björck's initial classification, * \< 18 years, * primary laparotomy performed through a non-midline incision, open abdomen, * if another laparotomy had been performed between the surgery for ba and the end of the follow-up period, * concomitant intra-abdominal surgery, abdominal complications during ba surgery, * adherent bowel to the defect edge that cannot be separated, * patients lost during follow up, * presence of intra-abdominal contamination that cannot be controlled radiologically, * history of previous ba repair, * stoma exteriorized from the midline primary wound, * temporarily wound closure techniques, * prior abdominal surgeries other than operation resulted in ba, * prior abdominal wall hernia repair with or without mesh, * history of collagen diseases

Keywords: abdomen burst, incisional hernia, mesh
esthetic crown lengthening with closed piezoelectric in comparison to open flap approach

Conditions: Altered Passive Eruption of Teeth

Summary: in this randomized clinical trial, the investigators are comparing two different approaches for esthetic crown lengthening- a minimally invasive approach using piezoelectric (pz) and a traditional open flap approach (of).

the altered passive eruption is diagnosed when there is an excessive gingival display with short clinical crowns. esthetic crown lengthening (ecl) is the most common surgical treatment of altered passive eruption. traditional ecl involves osseous resection with gingivectomy or apical displaced gingiva. the amount of soft and hard tissue removal in this technique aims to provide a healthy and esthetically acceptable crown height. however, gingival tissue coronal rebound is one of the most noted post-operative complications of traditionally used techniques. on the other hand, surgical techniques that include flap reflection may cause more coronal displacement of the gingival margin. hence, it is crucial to assess different surgical techniques to determine the most effective technique that gives the required outcomes with maximum patient satisfaction. piezoelectric bone surgery delivers high precision in resection, good tactile sensibility, and permits a selective cut of mineralized tissue while sparing soft tissue. further, the minimally invasive technique (mecl) was suggested to reduce pain, post-op discomfort, and procedure duration, and to accelerate the healing process. the mecl technique conveys a potential alternative approach as a sutureless, atraumatic, and less invasive technique that has been shown to increase patient satisfaction and comfort. in addition, using piezoelectric for osseous resection in this closed approach increases the favorable surgical outcomes. however, the osseous resection in mecl may be incomplete and results in a coronal rebound on the gingival contour. in addition, osseous resection in this approach is very technique sensitive to avoid root damage and uneven bone resection. a few studies and even a fewer clinical trials evaluated the clinical outcome of mecl using piezoelectric for osseous resection (pz). hence, in this randomized clinical trial, gingival margin and bone crest stability will be evaluated after a minimally invasive approach using piezoelectric (pz) and a traditional open flap approach (of).

Eligibility criteria:
inclusion criteria: * patients with a gummy smile due to ape (type 1b) in two or more maxillary anterior teeth * patients with normal muscular efficiency of the upper lip * patients with no vertical skeletal defects exclusion criteria: * patients with systemic condition that prevent periodontal surgery * patients who smoke * patients with previous periodontal surgery in the same area * pregnant women

Keywords: crown lengthening open-flap approach piezoelectric approach
registry experience at the washington hospital center, des - endeavor for myocardial infarction

Conditions: Coronary Artery Disease

Summary: single-center registry of patients treated with at least one endeavor, zotarolimus-eluting, stent as the primary treatment for acute coronary syndrome at the washington hospital center, with the aim of assessing clinical success and safety at 30 days, 6 months and annually for up to 3 years post endeavor stent implantation.

interventional cardiology was revolutionized by the invention of stents, initially with the bare-metal stents (bms) and recently with the drug-eluting stents (des).zotarolimus-eluting stents have shown promising results in randomized clinical trails, demonstrating a reduction of clinical and angiographic restenosis in comparison to bms, and comparable clinically-driven target lesion revascularization rates in comparison with sirolimus-eluting stents. while short-term and 1 year registry data is available from outside of the united states, it will be important to collect "real-world" data regarding the stent usage and outcomes in the united states. in this study we propose to follow patients who received at least one endeavor® stent as primary treatment for acs for up to 3 years post initial stent implantation.

Eligibility criteria:
inclusion criteria: * patients, male or female, \>18 years of age * patients presenting with acute coronary syndrome (acs), where acs is defined as st segment deviation of \>1mm or an elevation of the isoenzymes greater than 2x upper limit of normal * patients who received at least one endeavor drug-eluting stent at the washington hospital center exclusion criteria: * n/a
pneumatic sleeves and congestive heart failure

Conditions: Congestive Heart Failure

Summary: based on the reversal of the adverse cardiovascular parameters during laproscopic surgery and its influence on cardiac activity in healthy subjects, the investigators expect to improved cardiac function in patients suffering from congestive heart failure.


Eligibility criteria:
inclusion criteria: * chf (as clinically evaluated and asessed by tte) * gave informed consent * nyha class ii-iii * lvef equal or less than 40% exclusion criteria: * patients who could not sign informed consent * nyha class iv * oxygen saturation less than 90% under room air
oxckd1 -empowering healthy lifestyle choices in chronic kidney disease

Conditions: Chronic Kidney Disease

Summary: patients with kidney disease benefit from reducing the amount of salt in the food that they eat. the benefits include lower blood pressure and better kidney function. therefore, lowering the amount of salt that is eaten could reduce the number of people who will develop kidney failure. the effect on blood pressure could also reduce the number of strokes and heart attacks. similar benefits are also seen for people without kidney disease. guidelines for patients with kidney disease recommend that they lower the amount of salt that they eat, but most patients do not manage to do this. the reasons for this are not unclear, but are likely to reflect the difficulty that patients have in reducing the amount of salt in their food and the nature of the advice that they are given. the investigators have developed a package of interventions to help patients to make healthier choices that will lower their salt intake. the package helps patients to learn about salt in food and how to avoid it. it provide practical advice on cutting down on salt using information booklets, text messages, emails, telephone calls, and a website. participants will be recruited from hospital kidney clinics and general practice. the investigators will randomly allocate participants to receive either the normal care that they would get or to receive the new package of interventions to help them lower salt. the package of interventions will involve patients receiving text messages, telephone calls, emails and written information. they will complete a questionnaire and collect urine samples which will can be used to measure the amount of salt that they are eating. no more than 6 visits will be required. the study is funded by the british renal society which is a charity that funds research to help patients with kidney disease.


Eligibility criteria:
inclusion criteria: * participant is willing and able to give informed consent for participation in the study. * male or female, aged 18 years or above. * diagnosed with ckd and an egfr ≥ 20 ml/min/1.73m2 * participant has clinically acceptable laboratory data available to confirm the diagnosis. * able (in the opinion of the investigators) and willing to comply with all study requirements. * willing to allow his or her general practitioner and consultant, if appropriate, to be notified of participation in the study exclusion criteria: * female participants who is pregnant, lactating or planning pregnancy during the course of the study. * any other significant disease or disorder which, in the opinion of the investigator, may either put the participants at risk because of participation in the study, or may influence the result of the study, or the participant's ability to participate in the study. * inability to understand english or special communication needs because the interventions will use english and is not funded to deal with special communication needs. * known salt losing nephropathy

Keywords: chronic kidney disease