Kornimate/medical-research-clean huggingface dataset:
mulligan ankle taping on volleyball players

Conditions: Chronic Ankle Instability; Mulligan

Summary: 34 volunteer professional volleyball players with (n=12) and without (n=22) cai will include in the study. mulligan ankle taping will apply. measurements will take before and after the intervention. muscle tone, stiffness, and elasticity will measure with myotonpro hand-held device. the static balance will measure with single leg stance test(slst) while the eyes-closed, dynamic balance will measure with the y balance test(ybt). single leg hopping test(slht) will evaluate performance and an active position sense test will use for jps. during the static and dynamic balance and performance tests, the ankle's confidence will be evaluated with the visual analog scale (vas). the study aimed to determine the effect of mulligan fibular taping over the tibialis anterior(ta), peroneus longus(pl), gastrocnemius lateralis(gcl), and medialis(gcm) muscles on muscle tone, stiffness, elasticity, as well as the performance, joint position sense(jps), static and dynamic balance in female volleyball players with and without chronic ankle instability(cai).


Eligibility criteria:
inclusion criteria: * being between the ages of 15-24, * being a professional volleyball player, * training for 90 minutes at least 3 days a week, * turkish native speakers, * for participants with chronic ankle instability, those with a foot and ankle disability index score below 90% and a foot and ankle disability index-sport survey score below 75% were included. exclusion criteria: * an ankle sprain history in the last 6 weeks, * having a previous history of fracture in the lower extremity, * having bilateral chronic ankle instability, * pregnant athletes were excluded from the study.

Keywords: chronic ankle instability mulligan fibular taping muscle elasticity muscle stiffness muscle tone
effects of an exercise program on reaction time and mouse accuracy in esports athletes

Conditions: Quality of Life

Summary: this study is intended to evaluate the effects of an exercise program on the change of electronic sports (esports) athletes' reaction time and mouse click accuracy. the benefits of participation are directly related to exercise, and include improved thinking, performance, sleep, and quality of life.


Eligibility criteria:
inclusion criteria: 1. university of miami electronic sports (esports) club team members exclusion criteria: 1. non- university of miami electronic sports (esports) club team members 2. individuals who are not able to participate in a full body exercise program, whether due to injury or an underlying medical condition 3. individuals who cannot comprehend basic instruction on exercise whether due to a cognitive impairment or language barrier (ie: non-english speaker).

Keywords: exercise
a study to evaluate the immunogenicity and safety of seqirus quadrivalent influenza vaccine (qiv) in a pediatric population 6 months through 59 months of age.

Conditions: Influenza, Human

Summary: this is a study to assess the immune (antibody) response and safety of a seqirus split virion, inactivated quadrivalent influenza vaccine (seqirus qiv), in comparison with a us licensed 2016/2017 quadrivalent influenza vaccine (comparator qiv) in a healthy pediatric population 6 months through 59 months of age.


Eligibility criteria:
inclusion criteria: * male or female subject 6 months through to 59 months of age at the time of first vaccination and born between 36 and 42 weeks of gestation; * parent or legally acceptable representative able to provide written informed consent and be willing and able to adhere to all protocol requirements including blood draws. * subject is in generally good health as per the investigator's medical judgment exclusion criteria: * history of allergic reactions to egg proteins or any components of the study vaccines; * history of serious adverse reactions to any influenza vaccines; * history of guillain-barré syndrome or other demyelinating disease such as encephalomyelitis and transverse myelitis; * history of licensed or investigational influenza vaccination in the last 6 months; * clinical signs of active infection and/or an axillary temperature of ≥ 99.5°f / (≥ 37.5 °c) on the day of vaccination or within 48 hours preceding vaccination. * current or recent, acute or chronic medical conditions that in the opinion of the investigator are clinically significant and/or unstable * history of any seizures, with the exception of a single febrile seizure; * self-reported or known seropositivity suggestive of acute or chronic viral infection for human immunodeficiency virus, hepatitis b or hepatitis c; * known or suspected congenital or acquired immunosuppressive conditions; * current or recent immunosuppressive or immunomodulatory therapy * current or medical history of malignant neoplasms; * administration of immunoglobulin and/or any blood products within the previous 90 days preceding the administration of the study vaccine or planned administration during the study; * participation in a clinical trial or use of an investigational compound within 28 days prior to or 28 days after receiving the study vaccine, or plans to enter a study during this period; * vaccination with a licensed vaccine 21 days (for live or inactivated vaccines) prior to receiving the study vaccine, or plans to receive any licensed vaccine prior to the study exit visit. * medical conditions or treatment contraindicating intramuscular vaccination due to increased risk of bleeding. * family members of the employees of the investigator or study center with direct involvement in the study, or with other clinical studies under the direction of that investigator or study center.
neuromodulation pain therapy in combination with intensive physiotherapy

Conditions: Spinal Cord

Summary: in this project, the aim is to verify that neuromodulation therapy (spinal cord stimulation) in combination with intensive physiotherapy on a neurophysiological basis will lead to the restoration of mobility of lower limbs.

so far, posterior spinal cord neurostimulation (nm scs) has been applied as a standard in patients with the most severe forms of pharmacoresistant neuropathic pain. the most recent research of the last 1-2 years brings clinical findings that, in a mode and modified arrangement, it could even induce rhythmic muscle activity of the lower limbs and help in verticalization and assisted bipedal locomotion. in this project, the aim is to verify that neuromodulation therapy scs (spinal cord stimulation) in combination with intensive physiotherapy on a neurophysiological basis will lead to the restoration of mobility of lower limbs. in the therapy, the neuronal circuits of the lumbosacral region, where the so-called central pattern generators for locomotion are located will be targeted. neurostimulation of this area will generate motor movement patterns corresponding to the previous mapping of the corresponding muscle groups. these will be supported by intensive physiotherapy on a neurophysiological basis - thanks to it and the facilitation of movement by neurostimulation, global motor patterns will be triggered, and motor programs stored at the subcortical level will be activated. their memorization and subsequent spontaneous retrieval will facilitate sensorimotor learning techniques. current research further shows that neurostimulation stimulates neurons in rexed laminae 3-5, specifically a group of neurons designated as sc vsx2 and subsequently proprioceptive fibres. physiotherapy will enhance the effect of neuromodulation by stimulating proprioceptors using soft and neurophysiologically based techniques. proprioceptive fibres make connections to motoneurons and also ascend through the spinal cord to the brain, and thus reflex motor movements can be triggered. information about them is carried to the brain by ascending pathways, and thus a free awareness of the movement facilitated by the neurostimulator occurs. all these mechanisms should potentiate plasticity (and lead to the restoration of locomotion.

Eligibility criteria:
inclusion criteria: spinal cord lesion exclusion criteria: other neurological conditions

Keywords: spinal cord stimulation physiotherapy
metabolic derangements in acute heart failure syndrome

Conditions: Congestive Heart Failure

Summary: to determine the association of both neurohormonal and hemodynamic alterations associated with metabolic abnormalities in acute heart failure syndrome.


Eligibility criteria:
inclusion criteria: * adult (age \> 18 yrs) patients admitted to the heart failure intensive care unit (h22) with acute heart failure syndrome (ahfs) requiring placement of a pulmonary artery catheter for hemodynamically guided therapy. exclusion criteria: * history of congenital heart disease. * acute hf in the setting of acute myocardial infarction. * severe anemia * patients listed for cardiac transplantation. * terminal malignancy, aids or cns disease. * concomitant sepsis, ards, trauma, aortic dissection, or pericardial tamponade

Keywords: congestive heart failure
early identification and treatment of early hiv infection in côte d'ivoire

Conditions: HIV Infection

Summary: set-up of a biobank for patients with an estimated date of infection seroconverters: store plasma and cells samples at initial contact and during follow-up for future analysis and analysis in international collaborative cohort seroconverters.


Eligibility criteria:
inclusion criteria: * patients included in the last primo-ci anrs 1220 protocol * all hiv infected individuals diagnosed during a blood donation with an estimated date of hiv seroconversion that will respect the following criteria: (i) age ≥18 (ii) hiv-1 or hiv-1+2 infected, (iii) hiv-seronegative at the preceding donation; (iv) who returned to the clinic to be informed of their hiv test result (v) with an hiv serology confirmed with two specific tests in two different laboratories (vi) who have never received art for curative purpose * informed on study objectives and have a signed informed consent. exclusion criteria: * patient living outside of abidjan

Keywords: hiv cohort early hiv infection côte d'ivoire disease progression
effect of irvingia gabonensis (bush mango)on parameters associated with metabolic syndrome

Conditions: Metabolic Syndrome; Obesity; Dyslipidemia

Summary: the study investigated the use and efficacy of the seeds of african bush mango (irvingia gabonensis)to control body weight, blood lipids and hormones in overweight and obese people.

to assess the effects of seeds of irvingia gabonensis on body weight, fasting blood glucose, plasma total and ldl cholesterol in 102 overweight and obese participants. the study was a 10 week randomized, double blind, placebo controlled design. participants were randomly divided into 2 groups of 51 participants each. group 1 was the placebo group, while group 2 was the active group. each group received 2 daily doses of 125 mg (before meals) of either placebo or irvingia gabonensis. weight as well as fasting blood was taken at baseline and at 4, 8 and 10 weeks. no major detary changes or exercises were suggested during the study period.

Eligibility criteria:
inclusion criteria: * bmi\>26 exclusion criteria: * diabetics pregnant and lactating participating in any other weight reducing program smokers

Keywords: weight loss antiobesity metabolic syndrome leptin
understanding daily changes in bdd risk using smartphones

Conditions: Body Dysmorphic Disorders

Summary: body dysmorphic disorder (bdd) is associated with high risk for suicide attempts (22-28%) and substance use disorders (49%), underscoring the importance of accurate, real-time risk detection in bdd. this study aims to use smartphone-based digital phenotyping to develop and validate unobtrusive, time-sensitive, and ecologically valid measures of key risk factors for suicide and substance misuse in bdd: negative affect states. as next steps, this research can be extended to detect risk transdiagnostically, with the goal of enabling just-in-time interventions to target suicide and substance misuse across psychiatric illnesses.


Eligibility criteria:
inclusion criteria: * adults age \>=18 * current primary diagnosis of bdd * bdd severity \>= moderate * living in us * english proficiency * owns an android or ios (apple) smartphone * has regular wifi-enabled internet access for data downloads
the effect of increased water intake on the frequency of the clinical recurrent urinary tract infections in pre-menopausal women: s-hydracyst

Conditions: Recurrent Urinary Tract Infection

Summary: the purpose of this study is to determine whether increased water intake is effective in preventing episodes of uncomplicated urinary tract infections (uti) in pre-menopausal women suffering from uti recurrences.

this study aims to assess the effect of increased daily water intake on the frequency of clinical, recurrent urinary tract infections (uti) among low drinking pre-menopausal women suffering from recurrent community-acquired uti over 12 consecutive months of study product consumption. it is a prospective, single site, open-label, randomised controlled trial in two parallel groups: * control group: not changing their fluid intake habits * intervention group: provided with mineral water, fluid intake recommendations and regular hydration coaching support the study population consists in pre-menopausal women diagnosed with recurrent utis and having a 'low drinker' profile. the total number of randomized subjects in this study is estimated at 140. the study will include only women who are low-drinkers (\< 1.5 l fluids per day; urinary volume \< 1.2 l per day) since they are most likely to have a predisposition to utis due to infrequent voiding.

Eligibility criteria:
inclusion criteria: * at least 3 clinical recurrences of symptomatic uti in the last 12 months * age ≥ 18 years exclusion criteria: * incapacity / non-willingness to consume 1.5 l of drinking water per day on top of their usual consumption * women with history of uti complications (pyelonephritis or other) in the last 12 months * subjects with interstitial cystitis * subjects with severe or uncontrolled organic disease, likely to interfere with the parameters of the study

Keywords: urinary tract infections water intake
factors influencing quality of bowel cleansing for colonoscopy in patients with colorectal cancer surgery; prospective observational study

Conditions: Colorectal Cancer

Summary: the aim of this study is to clarify the factors influencing quality of bowel cleansing for colonoscopy in patients with colorectal cancer surgery and confirm the adequate bowel cleaning method for patients with colorectal cancer surgery. through this, ultimately in patients with a history of colorectal cancer who have high risk of colorectal cancer, it could be possible to detect cancerous lesions early and increase the survival rate. this study is based on observational study subjects are the patients with colorectal cancer surgery who visits the out patients clinic for follow-up colonoscopy the patient's medical records on the basis of information collected at the point of the colonoscopy performed quality of bowel cleansing is calculated with the boston bowel preparation scale patient compliance and satisfaction are measured.


Eligibility criteria:
inclusion criteria: * age ≥ 20 * patients who underwent colorectal cancer surgery * patients who underwent follow-up colonoscopy as a conventional medical procedures exclusion criteria: * age \< 20 * patients who have ileus or bowel obstruction * patients in pregnant status * patients who did not consent to research

Keywords: bowel cleansing, colorectal cancer surgery
relationship between intestinal flora changes and hyperuricemia under chronic psychological stress

Conditions: Hyperuricemia

Summary: to clarify the mechanism of stress on the incidence of hyperuricemia

to clarify the differences in intestinal microorganisms and metabolism between healthy people and hyperuricemia patients and across different level of stress

Eligibility criteria:
inclusion criteria: 1. obtain the informed consent of the subjects before conducting any trial-related activities; 2. males aged 18-69; 3. the hyperurcemia group must meet the diagnostic criteria of having blood uric acid \>420umol/l measured twice on an empty stomach on different days under a normal purine diet; exclusion criteria: - 1)use of any uric acid-lowering drugs, anti-gout drugs, steroids, proton pump inhibitors, or non-steroidal anti-inflammatory drugs within one month before enrollment; 2)use of any antibiotics, probiotics, or other drugs including traditional chinese medicine within one month before enrollment; 3)abnormal liver function, alt and ast are more than 2.5 times the upper limit of normal; 4)other diseases that affect glucose and lipid metabolism: hyperthyroidism, hypothyroidism, hypercortisolism, etc. 5)chronic kidney disease or severe renal impairment, according to egfr grading \<45ml/min/1.73m2; 6)secondary hyperuricemia 7)any gastrointestinal diseases
parallel-arm study to compare ad109 to placebo with patients with osa (synairgy study)

Conditions: OSA

Summary: this is a phase 3 randomized double-blind placebo-controlled 6-month parallel-arm study to compare a fixed dose combination of ad109 to placebo in obstructive sleep apnea.


Eligibility criteria:
inclusion criteria: 1. ≥18 years of age at the time of informed consent. 2. psg criteria: ahi of ≥10 and ≤45; ≤ 25% central or mixed apneas; and plm arousal index ≤15 3. promis-fatigue: raw score ≥17 4. pap intolerance or current pap refusal. 5. bmi between 18.5 and 40 kg/m2 for men, or 42 kg/m2 for women, inclusive. exclusion criteria: 1. narcolepsy, restless leg syndrome, rem sleep behavior disorder 2. insomnia disorder characterized by difficulty initiating or maintaining sleep, or use within the past month of sedative-hypnotics or other medication for the purpose of treating or avoiding insomnia symptoms. 3. pierre robin, treacher collins, or other craniofacial malformation syndrome, or grade ≥3 tonsillar hypertrophy. 4. clinically significant cardiac disease, e.g., ventricular arrhythmia, untreated or unstable coronary artery disease, cardiac failure. stable atrial arrhythmia is allowed. 5. neuromuscular disorder (e.g., motor neuron disease, muscular dystrophy or myopathy, myasthenic syndrome); epilepsy; parkinson, alzheimer, or other neurodegenerative disease. exclusion criteria: -

Keywords: obstructive sleep apnea
relationship between fungal colonization and severe bronchopulmonary dysplasia

Conditions: Bronchopulmonary Dysplasia; Extreme Prematurity; Fungal Infection

Summary: the aim of this study is to determine if fungal colonization is associated to severe bronchopulmonary dysplasia in premature infants less than 29 weeks of gestation, and to determine if an association exists between fungal colonization and complications of prematurity and death.

fungal colonization is common in premature infants. certain neonatal departments, routinely screen for fungal colonization by weekly cultures, while other departments perform fungal cultures solely in the presence of suggestive clinical or biological signs such as hyperleucocytosis, maternal vaginal candidiasis, sepsis and characteristic skin lesions. this neonatal colonization can progress to an invasive fungal infection leading to death and comorbidities. a relationship between fungal colonization and severe bronchopulmonary dysplasia is suspected.

Eligibility criteria:
inclusion criteria: * premature infants inferior to 29 weeks of gestation screened for fungal colonization, * admitted in the neonatal department of centre hospitalier sud francilien, * between january 1st 2018 and december 31st 2020, * holders of parental authority informed of the study that are unopposed exclusion criteria: * premature infants over 29 weeks of gestation, or term infants, * premature infants less than 29 weeks of gestation not screened for fungal colonization during their hospitalization, * premature infants with significant congenital malformations or genetic abnormalities, * premature infants inferior to 29 weeks of gestation deceased in delivery room.

Keywords: extremely premature infants bronchopulmonary dysplasia fungal infection
clinical decision support for mechanical ventilation of patients with ards

Conditions: Acute Respiratory Distress Syndrome

Summary: perform a pilot study of quality improvement interventions for critical care physicians (intensivists) and respiratory therapists (rts) to improve application of low tidal volume mechanical ventilation (ltvv) for patients with the acute respiratory distress syndrome (ards) using the computerized mechanical ventilation protocols currently available in the investigator's cerner electronic health record (ehr).

a multidisciplinary team of implementation researchers and clinical effectiveness researchers has been assembled to adapt the consolidated framework for implementation research (cfir) for this planning study. the team identified the baseline clinical care delivery for ltvv in patients with ards across intermountain hospitals and identified the barriers and facilitators to this standard of care. this pilot implementation study will focus on a pilot solution aimed at achieving ideal clinical care delivery of ltvv for patients with ards. abbreviations for mechanical ventilation: peep: positive end expiratory pressure fio2: fraction of inspired oxygen cpap: continuous positive airway pressure ps: pressure support vc: volume control vc+: hybrid mode for volume targeted ventilation on puritan bennett ventilators prvc: pressure regulated volume control, hybrid mode for volume targeted ventilation on draeger ventilators pf ratio: ratio of partial pressure of arterial oxygen (pao2 mmhg) divided by the fio2 expressed in liters

Eligibility criteria:
inclusion criteria: 1. invasive mechanical ventilation 2. pf ratio \<255 3. bilateral infiltrates on chest radiograph (adjudicated by a co-investigator) 4. presence of ≥1 risk factor for ards as determined by review of the her exclusion criteria: 1. age \<18 years 2. pulmonary capillary wedge pressure \>18 mm hg if a right heart catheter is present 3. prisoner 4. known to be pregnant 5. death \<24 hours from initial intubation 6. placed comfort care \<24 hours from initial intubation 7. mechanically ventilated for \>7 days prior to meeting ards criteria

Keywords: ards lung protective mechanical ventilation clinical decision support
focused ultrasound thalamotomy for tremor relief in atypical parkinsonism

Conditions: Atypical Parkinsonism; Dementia With Lewy Bodies; Multiple System Atrophy, MSA

Summary: the goal of this retrospective observational study is to describe the efficacy of focused ultrasound ventral-intermediate nucleus thalamotomy in patients with atypical parkinsonism. * is this treatment efficacious in patients with multiple system atrophy? * is this treatment efficacious in patients with diffuse lewy body dementia? data will be collected from patients charts.


Eligibility criteria:
inclusion patients that underwent fus ventral-intermediate nucleus thalamotomy suffer from multiple system atrophy-parkinsonian type (msa-p) or dementia with lewy bodies (dlbd). - exclusion criteria: * patients that did not underwent fus ventral-intermediate nucleus thalamotomy * patients that underwent fus ventral-intermediate nucleus thalamotomy and do not suffer from msa or dlbd

Keywords: focused ultrasound tremor surgery thalamotomy