Kornimate/medical-research-clean huggingface dataset:
peripheral blood stem cell combined with mesenchymal stem cells for treatment of poor graft function

Conditions: Stem Cell Transplantation, Hematopoietic; Poor Graft Function; Hematological Diseases

Summary: the purpose of this study is to evaluate the utility of treating patients experiencing poor graft function after allogeneic hematopoietic stem cell transplantation with granulocyte colony-stimulating factor (g-csf) mobilized peripheral stem cell combined (pbsc) with ex-vivo-expanded bm-drived mesenchymal stem cells from third-party donors. our first objective was to evaluate the effect of such treatment on poor graft function, and second object was to investigate the safety of such treatment.

allogeneic hematopoietic stem cell transplantation(allo-hsct) is the only cure for many hematologic diseases. however, poor graft function (pgf) is an important complication after allo-hsct that occurs in 5-27% of patients, and is associated with considerable mortality related to infections or hemorrhagic complications. treatment of pgf usually involves the prescription of hematopoietic growth factors such as granulocyte colony-stimulating factor (g-csf), or second transplantation, but these methods are associated with dismal effect or even a significant risk of graft-versus-host disease (gvhd). mesenchymal stem cells (mscs) are a form of multipotent adult stem cells that can be isolated from bone marrow (bm), adipose tissue, and cord blood. clinical applications of human mscs include improving hematopoietic engraftment, preventing and treating graft-versus-host disease after allo-hsct and so on. some studies have shown that mscs combined with pbsc or cord blood could be useful to improve engraftment after hsct. several reports suggested mscs might be effective in the treatment of pgf. however, the efficacy of mscs as single-drug treatment for pgf is unsatisfactory in our previous study. therefore, in the present study, g-csf mobilized pbsc will be used combined with mscs in the patients with pgf after allo-hsct.

Eligibility criteria:
inclusion criteria: * a patient age of 14-65 years * poor graft function developing after allo-hsct * subjects (or their legally acceptable representatives) must have signed an informed consent document indicating that they understand the purpose of and procedures required for the study and are willing to participate in the study exclusion criteria: * any abnormality in a vital sign (e.g., heart rate, respiratory rate, or blood pressure) * patients with any conditions not suitable for the trial (investigators' decision)

Keywords: poor graft function peripheral blood stem cell mesenchymal stem cells allogeneic hematopoietic stem cell transplantation
evaluation of flexofytol® plus in hand joint chronic dyscomfort.

Conditions: Hand Joint Discomfort

Summary: the purpose of this study is to evaluate the effect of curcuminoids and boswellia serrata extracts combination (flexofytol plus) in support to standard treatments during a 12-weeks period on hand pain on people with chronic hand joint discomfort.


Eligibility criteria:
inclusion criteria: * older dan 45 years old, * with hand joint chronic discomfort, * regularly uses of paracetamol or nsaids to manage pain, * painful symptoms must have been present for more than 6 months, * the patient assesses their pain on a visual pain scale and must be greater than 4 out of 10 over the last 48 hours. exclusion criteria: * related to previous and associated treatments: * corticosteroids injection in the 3 previous months, whatever the joint concerned, * use of slow-acting drugs for oa and/or dietary supplements taken within less than 6 months prior to the study (ex: chondroitin sulfate, diacerein, soy and avocado unsaponifiables, oxaceprol, granions de cuivre, glucosamine, phytotherapy or homeopathy for hand joint discomfort..), * anticoagulant (coumarinic) treatment and heparin, * general corticotherapy in the 3 previous months, * contraindication to paracetamol, curcumin, boswellia and nsaid's. * related to associated pathologies: * patient suffering from serious associated illness (liver failure, kidney failure, non-controlled cardiovascular diseases...), * the patient has rheumatoid arthritis or gout, * the patient has a bile obstruction. * related to patient: * pregnant or breastfeeding women.

Keywords: hand joint pain curcumin boswellia serrata support to standard treatment
a safety, tolerability and efficacy study with qbw251 in copd patients with qbw251

Conditions: Chronic Obstructive Pulmonary Disease, COPD

Summary: to evaluate the efficacy, safety and tolerability of multiple doses of qbw251 vs placebo administered orally, on airway function, lung volume, and quality of life in patients with chronic obstructive pulmonary disease (copd)


Eligibility criteria:
inclusion criteria: must have a diagnosis of gold ii-iii chronic obstructive pulmonary disease (copd); must have clinical diagnosis of chronic bronchitis; must be either a current smoker (smoked ≤ 1 pack per day on average for the last 3 months with at least a 10 pack year smoking history) or an ex-smoker with at least a 10 pack year smoking history; exclusion criteria: must not be receiving chronic, daily, systemic steroids; must not have severe emphysema (determined by hrct); must not have had a copd exacerbation or respiratory tract infection requiring antibiotics or oral steroids or hospitalization within 6 weeks of screening; must not be pregnant or nursing or a woman of child bearing potential; other protocol-defined inclusion/exclusion criteria may apply

Keywords: copd, chronic bronchitis, inflammation, airway, lci, pulmonary function test, lung function, controlled clinical trial, randomized, airflow, smoker
study of mattress type in fibromyalgia

Conditions: Fibromyalgia

Summary: the purpose of this research study is to determine if a new mattress relieves the symptoms of fibromyalgia and improves sleep, and if this is the case, whether one type of mattress is better than the other in doing so.

the various stages of sleep will be monitored via polysomnography(psg) and scored to indicate the degree to which they reflect a normal sleep pattern. changes in the severity of fibromyalgia symptoms will be assessed by tender point exam and study questionnaires administered at 2 month intervals.

Eligibility criteria:
inclusion criteria: * female subjects who fulfill the american college of rheumatology's case definition for fibromyalgia -- that is they have both wide spread pain and more than 10 of the 18 tender points * 18 years of age or older * has to be on stable medications and followed by one physician exclusion criteria: * subjects with the existence of an undiagnosed sleep disorder - namely obstructive sleep apnea or periodic leg movement syndrome * pregnancy

Keywords: mattress tempur-pedic fibromyalgia sleep patterns
low dose bismuth versus lactobacillus reuteri for h. pylori eradication

Conditions: Helicobacter Pylori Infection

Summary: this study investigates the efficacy of a b.i.d. quadruple therapy containing pylera® or l. reuteri for h. pylori infection.

bismuth, metronidazole and tetracycline yielded high cure rates for h. pylori infection. earlier studies suggested that the bismuth quadruple therapy may be effective when given twice-a-day rather than q.i.d. and that b.i.d. therapy was associated with fewer side effects. the addition of the probiotic lactobacillus reuteri (gastrus®) to lactobacillus reuteri (gastrus®) that has been shown to increase the cure rates by 10-14%. in another study bismuth supplementation with l. reuteri dsm 17938, in a modified low dose quadruple therapy provided good eradication rates (93.3%; 95% ci : 85-99%) in clinical practice.

Eligibility criteria:
inclusion criteria: - positive for h. pylori infection exclusion criteria: * presence of malignancy * pregnancy or lactation * clinically significant diseases * history of drug or alcohol abuse * allergy to pantoprazole or to any component of regimens used in the study * use of anti-secretory drugs, antibiotics or probiotics 4 weeks preceding the enrollment.

Keywords: lactobacillus reuteri; bismuth; helicobacter pylori;
pii ngima: consequences of water insecurity for maternal and child health

Conditions: Maternal and Child Health; HIV

Summary: this study will implement the validated household-level water insecurity scale developed by study investigators among a cohort of postpartum women in nyanza, kenya and will assess a range of outcomes linked to water insecurity, such as viral load, hydration status, maternal depression, stress, food insecurity, and cognitive development.

this study will develop the first well-known household water insecurity scale. currently, water insecurity cannot be measured at the level of the household or individual, i.e. at the endpoint of water use. although there are myriad national, regional, community, and hydrological indexes of water availability, to the investigators' knowledge, there is no way of measuring water access at the household or individual levels. without a comprehensive, validated scale to measure household water insecurity, the scientific, programmatic, and public health communities cannot empirically test the prevalence of household water insecurity access and its potential impacts on economic, nutrition, disease, and psychosocial health pathways and outcomes.

Eligibility criteria:
inclusion criteria: * women \>18 years of age with infants enrolled into the pith moromo (clinical trials id: nct02974972) study * infants born to pregnant women enrolled in the cohort study exclusion criteria: * individuals \<18 years of age that are not infants born to women enrolled in the cohort study

Keywords: water insecurity
prevalence of metabolic syndrome in patients with schizophrenia in korea

Conditions: Schizophrenia; Metabolic Syndrome

Summary: the aim of this study is to examine the prevalence of the metabolic syndrome(mets) in korean patients with schizophrenia. primary objective: • to investigate the prevalence of the mets in korean patients with schizophrenia secondary objectives: • to compare the prevalence of the mets among 3 groups according to antipsychotics: typical antipsychotic monotherapy group, atypical antipsychotic monotherapy group, 2 or more antipsychotics group (polypharmacy)


Eligibility criteria:
inclusion criteria: * diagnosis of schizophrenia according to dsm-iv-tr * age between 18-65 years

Keywords: prevalence korea
usability of diabetes dashboard embedded within a patient web portal

Conditions: Diabetes Mellitus, Type 2

Summary: the purpose of this study is to conduct a prospective, longitudinal study to evaluate the usability of a patient-facing diabetes dashboard delivered via an established patient web portal.

up to 70 adult patients with type 2 diabetes mellitus will be enrolled and given access to a diabetes dashboard within an existing patient web portal. patients will be invited by mail (or email) to be screened for enrollment in the study. patients may also respond at a study flyer and contact the study team to be screened for enrollment. eligible and interested patients will be emailed a link to a secure study website where they will complete a web consent form. after enrollment, participants will complete a baseline web-based questionnaire. after completing the enrollment questionnaire, they will be provided access to the diabetes dashboard within the patient web portal for one month. after one month, participants will receive an additional follow-up (final) questionnaire to assess outcomes.

Eligibility criteria:
inclusion criteria: * type 2 diabetes mellitus * currently being treated with at least one antihyperglycemic medication * able to speak and read in english * have reliable access to a computer with internet access * existing my health at vanderbilt (i.e., patient portal) account exclusion criteria: * living in long term care facilities * known cognitive deficits * severe visual or hearing impairment * unintelligible speech (e.g., dysarthria) * currently participating in another diabetes-related research study

Keywords: diabetes patient web portals usability health information technology
early strengthening rehabilitation training for post-operative fracture distal radius

Conditions: Distal Radius Fracture

Summary: the primary objective of this study is to demonstrate safety and efficacy of an early strengthening and passive mobilization rehabilitation program for post-operative distal radius fracture fixation surgery compared to current conventional rehabilitation.

functional outcome after distal radius fracture fixation has often been variable with multiple factors affecting final results. early mobilization rehabilitation protocols have been the gold standard after fracture fixation surgery. rehabilitation protocols vary from center to center's own practices. however, these commonly encompass an early mobilization protocol or otherwise known as accelerated rehabilitation or enhanced recovery after surgery (eras) programs. such programs comprise of a short duration of immobilization followed by a period of active mobilization before strengthening exercises are employed. the investigators have performed early motion protocol (emp) rehabilitation in the last decade in the investigation center for post-operative fracture distal radius fixation patients. the early motion protocol allows immediate active mobilization without a period of immobilization or splint protection. despite early mobilization rehabilitation, there are a subset of patients who develop significant stiffness and pain with poor functional outcomes, especially in the early post-operative period. moreover, some patients may also develop complex regional pain syndrome (crps) albeit early active mobilization. thus, an early strengthening protocol (esp) was developed to allow for immediate strengthening and passive mobilization exercises post-operatively with physiotherapist and occupational therapist guidance. herein this study, the investigators hope to demonstrate the safety and efficacy of an esp rehabilitation compared to emp for post-operative distal radius fracture fixation.

Eligibility criteria:
inclusion criteria: * aged 50 years or older * diagnosed with an isolated closed injury, displaced, distal radius fracture (ao/ota classification 23-a1-3, b1-2, c1-2) without articular comminution * requires operative fixation * able to give consent exclusion criteria: * history of previous hand or wrist surgery * neurological injury or pre-existing neurological conditions to the upper limb * underlying osteoarthritis of the wrist * unfit for surgical anesthesia * subacute fractures with delayed presentation (\>2 weeks since initial injury) * unable to consent * refuse surgical intervention * unable to follow commands for rehabilitation * fixation construct or injuries requiring immobilization after surgery, such as unfixed distal ulna head or shaft fractures that require splintage or distal radio-ulnar joint instability planned for immobilization

Keywords: distal radius fracture rehabilitation patient outcomes physiotherapy occupational therapy orthopaedic fracture repair
treatment for aggression and agitation in patients with alzheimer's disease

Conditions: Alzheimer's Disease

Summary: the purpose of this study is to determine whether this drug can help symptoms of aggression and agitation in participants with alzheimer's disease.

the primary purpose of this study is to help answer the following research questions: * whether this drug can help symptoms of aggression and agitation in participants with alzheimer's disease. * the safety of this drug and any side effects that might be associated with it. * how this drug compares to placebo. during the 12-week period of this study, the participant will have an equal chance of receiving 1 of the 2 treatment groups: active drug or placebo.

Eligibility criteria:
inclusion criteria: * community-dwelling participants with a diagnosis of probable alzheimer's disease (ad) based on disease criteria from the national institute of neurological and communicative disorders and stroke (nincds) and the alzheimer's association. mini mental state examination (mmse) score from 6 to 26 inclusive; neuropsychiatric inventory-10 (npi-10) total score greater than or equal to 10. * are men or women at least 60 years old. * weight greater than or equal to 45 kilograms (kg). * have clinically significant and persistent verbal or physical agitation and/or verbal or physical aggression behaviors that are disruptive to daily functioning or potentially harmful and occurred at least 3 days per week over the past 4 weeks prior to study entry. * understand english. * have a reliable and actively involved caregiver who must be able to communicate in english and be willing to comply with protocol requirements. exclusion criteria: * meet dsm-iv-tr or delirium rating scale-revised-98 criteria for delirium. * does not score ≤4 on the modified hachinski ischemia scale for vascular dementia. * have a magnetic resonance imaging (mri) or computer tomography (ct) scan on file since the onset of symptoms of ad and performed within the past 24 months that is inconsistent with a diagnosis of ad. * have a current, required use, or expected use of psychoactive drugs or other medications not allowed in this trial. * have currently active significant medical, neurological, or psychiatric problems that are not allowed in this trial or other brain disorders. * have received acetylcholinesterase inhibitor (acheis) or memantine for less than 4 months, or have less than 2 months of stable therapy on these treatments by visit 2.

Keywords: agitation and aggression
screening for memory studies

Conditions: Memory Loss; Memory Deficits; Dementia

Summary: we hope to recruit participants into various clinical trials and research projects.

the purpose of this protocol is to advertise, recruit, and do a preliminary screen for various clinical trials. anonymous information collected will be entered in a database available to researchers connected with the stanford/va aging clinical research center, located at va palo alto health care system, palo alto division.

Eligibility criteria:
inclusion criteria: * age 55 or over. exclusion criteria: * major psychiatric problems. * major medical problems. * aversion to test-taking.

Keywords: memory loss
phase iii, long-term, open-label, extension study of 0.1% tacrolimus(fk506) ophthalmic suspension in patients with vernal keratoconjunctivitis

Conditions: Keratoconjunctivitis; Conjunctivitis

Summary: to investigate the long-term efficacy and safety of fk506 ophthalmic suspension in patients with vernal keratoconjunctivitis

to give a chance of continuous use of 0.1% fk506 ophthalmic suspension to patients with vernal keratoconjunctivitis who were enrolled in the fj-506d-ac09 study, long-term safety and efficacy were evaluated. primary efficacy endpoint was the mean change from the baseline (before the treatment) in total score for objective clinical signs.

Eligibility criteria:
inclusion criteria: * vernal keratoconjunctivitis patients who were enrolled in the fj-506d-ac09 study * patients who wish to receive continuous administration of fk506 ophthalmic suspension exclusion criteria: * subjects who needed prohibited concomitant therapy at the initiation of the study * subjects who needed to wear contact lenses during treatment period on a testing eye * subjects with complicating an eye infection

Keywords: keratoconjunctivitis vernal keratoconjunctivitis fk506 tacrolimus
evaluation of the sacroiliac joints of people with chronic low back pain from a chiropractic perspective

Conditions: Back Pain

Summary: low back pain is a musculoskeletal problem that we commonly encounter in the clinic,which negatively affects the quality of life, reduces productivity and limits the ability to perform activities of daily living.

the most common causes of low back pain are disc lesions and soft tissue injuries due to trauma, rheumatological disorders such as spondylosis, spinal stenosis and spondylolisthesis, ankylosing spondylitis and rheumatoid arthritis due to degenerative changes; osteoporosis, root disorders, and sacroiliac joint dysfunction

Eligibility criteria:
inclusion criteria; * volunteer * not undergoing surgery related to the lumbar region * cases without lumbar steroid injection in the last 3 months * not having visual and hearing loss * having low back pain * cases without neurological problems * cases without tumor and infection in the lumbar region * cases in which communication and cooperation are provided exclusion criteria; * not having a musculoskeletal or neuromuscular disease that limits mobility, * no upper extremity sequelae, * not volunteering

Keywords: sacroiliac
lsfg-skin, laser speckle flowgraphy

Conditions: Hypertension; Heart Failure; Vascular Ischemia; Burns; Chemotherapy Effect; Radiation Injuries; Uveitis; Scleritis; Multiple Sclerosis; Autonomic Neuropathy; Stroke; Intracranial Hemorrhages; TIA; Migraine; Headache; Pain

Summary: the purpose of this project is to quantify normal and abnormal skin blood flow regionally in different areas of the body(face, extremities, over burns and wounds) at baseline and over time in response to treatment or environmental changes, such as temperature, light and pressure.

laser speckle skin blood flow (lsfg-skin) will be recorded in normal subjects and in patients with disorders affecting skin capillary perfusion, which may include cardiovascular disorders, dermatologic disorders, skin wounds, ocular disorders, psychiatric disorders, and neurologic disorders.

Eligibility criteria:
inclusion criteria: controls ●healthy normal control subjects ages 18-90 cardiology subjects * ages 18-90 * history of dysrhythmia, heart failure, cardiac ischemia, hypertension, peripheral vascular disease dermatology subjects * ages 18-90 * history of inflammatory and cancerous lesions endocrine subjects * ages 18-90 * history of diabetes, thyroid disease neurology subjects * ages 18-90 * history of dementia, headaches, parkinson's, light sensitivity, stroke, tia, multiple sclerosis psychiatry subjects * ages 18-90 * history of bipolar, schizophrenia, anxiety, depression surgery subjects * ages 18-90 * history of skin wounds(trauma, chemotherapy, radiation), thermal burns, or plastic and reconstructive surgical procedures. ophthalmology subjects * ages 18-90 * history of ocular disorders caused by hypo perfusion or inflammatory disorders exclusion criteria: controls * cataract or media opacity that would degrade the imaging of the retina. mild cataracts are okay. * angle closure glaucoma cardiology subjects * cataract or media opacity that would degrade the imaging of the retina. mild cataracts are okay. * angle closure glaucoma 3. dermatology subjects * cataract or media opacity that would degrade the imaging of the retina. mild cataracts are okay. * angle closure glaucoma endocrine subjects * cataract or media opacity that would degrade the imaging of the retina. mild cataracts are okay. * angle closure glaucoma neurology subjects * cataract or media opacity that would degrade the imaging of the retina. mild cataracts are okay. * angle closure glaucoma psychiatry subjects * cataract or media opacity that would degrade the imaging of the retina. mild cataracts are okay. * angle closure glaucoma surgery subjects * cataract or media opacity that would degrade the imaging of the retina. mild cataracts are okay. * angle closure glaucoma ophthalmology subjects * cataract or media opacity that would degrade the imaging of the retina. mild cataracts are okay. * angle closure glaucoma

Keywords: perfusion inflammatory ischemia lesions neuropathy burns cancer stroke