Kornimate/medical-research-clean huggingface dataset:
home-based exercise for adults living with overweight and obesity

Conditions: Overweight and Obesity

Summary: the study aims to implement a 12-week home-based exercise programme utilising an online intervention delivery platform. the focus will be on increasing exercise behaviour within the participant's home setting using aerobic, resistance and flexibility exercises as well as behaviour change techniques. following the programme, semi-structured interviews will be conducted, to explore participant experiences. it is hypothesised that the exercise programme will be feasible, accessible and acceptable.


Eligibility criteria:
inclusion criteria: * bmi ≥25kg/m² or bmi ≥30kg/m² * english speaking * able to follow visual and verbal instructions * access to the internet and accompanying technology (e.g. laptop or tablet) * physically able to undertake aerobic, resistance and flexibility exercise exclusion criteria: * unable to provide informed consent * receiving invasive medical treatment or planned surgery preceding to, or during, the programme * severe mental or physical limitations precluding participation safely in the home environment * no access to the internet and/or facilitative technology such as a laptop or tablet * pregnancy * current smoker or vaping. * currently or very recently stopped taking weight loss medication (within the last two weeks) * recently experienced substantial weight change (defined as 5% within 6-12 months) * presence of contraindications to exercise * pacemaker and/or other implanted metal device * at high risk of cardiovascular event

Keywords: home-based exercise
impact of exergaming on adolescent youth

Conditions: Childhood Obesity

Summary: the purpose of this study is to gather information on how much exercising with video games (exergaming) can increase the physical activity among overweight and youth. this study will try to see if participating in physical activity and exercising with video games at the same time can make overweight children move around more to better their own health. the hypothesis is that those in exergaming arm will physiological changes and increase physical activity.


Eligibility criteria:
inclusion criteria: * male and female * aged 12-14 years * baseline bmi \> 25 * gender- and age-specific 85th percentile cutoff points from the cdc growth chart * parental consent and subject assent exclusion criteria: * subjects not meeting the inclusion criteria or with physician-determined musculoskeletal, cardiopulmonary, metabolic, psychological, neuro-developmental or behavioral conditions that make mild-to-moderate physical activity potentially hazardous. * participants under the age of 12 are excluded from the study because weingart ymca has an age policy. children under the age of 12 are not allowed to be at the facility alone. therefore, the minimum age for the study is 12 years old so supervision is not a problem.

Keywords: adolescent obesity
role of pseudogene in incontinentia pigmenti, and its potential treatment

Conditions: Incontinentia Pigmenti

Summary: incontinentia pigmenti (ip) is an x-linked dominant ectodermal dysplastic disorder. it is due to loss of function of nf-kappa b essential modulator (nemo, inhibitor of kappa light polypeptide gene enhancer in b cells, kinase of gamma, ikbkg), an important regulator of the nf-kb pathway. major clinical manifestations of ip include swirling skin pigmentary changes, and anomalies in organs including the eyes, dental, bones, nervous system, and heart. affected male mostly die before birth. older patients might have immunodeficiency, psychomotor retardation, and seizures. prenatal diagnosis is difficult. ikbkg gene is 35 kb in length, and contains 10 exons. a pseudogene (∆nemo, ikbkgp), located distal and in inverse direction to the true gene, contains only exon 3-10. in patients with ip, the most common mutation was exon 4-10 large deletion. but the investigators have found small mutations derived from the pseudogene in taiwanese patients. the three aims of this study are the role of pseudogene in ip, the frequency of recombination between ikbkg and ikbkgp, and possible treatment. to achieve the first aim, the investigators first develop a pseudogene-specific polymerase chain reaction (pcr). the investigators will first obtain the frequency of ikbkgp gene mutation in normal individuals. the investigators will then detect ikbkgp related mutations in ip patients presenting classical or non-classical symptoms. the latter group of patients, who may have isolated hair, teeth, retinal, or immune problems, are more likely to be caused by point mutations. the second aim of this study is to estimate the incidence of ikbkg and ikbkgp recombination. because these two genes are in opposite position, recombination after dna loop back is likely to occur in somatic cells. the investigators will transform lymphocytes containing ikbkgp mutation, and culture them continuously. ikbkg mutation will be check intermittently and the incidence can be estimated. the third aim is to find a treatment. the investigators will test the read-through drug gentamycin and ptc2124 for nonsense mutation. either fibroblast or epstein-barr virus (ebv) - transformed lymphoblasts will be tested. the investigators hope this study with not only increases our understand to ip, and also improves the investigators' knowledge toward genetic diseases.


Eligibility criteria:
inclusion criteria: * patients diagnosed to have incontinentia pigmenti exclusion criteria: * none

Keywords: incontinentia pigmenti recombination ikbkg ikbkgp
sublingual fentanyl and procedural burn pain

Conditions: Burn Pain

Summary: the purpose of this study is to examine the efficacy and safety of sublingual fentanyl spray (subsys) for procedural pain (dressing changes/minor debridement) in patients with burn injury.

the purpose of this study is to examine the efficacy and safety of sublingual fentanyl spray (subsys) for procedural pain (dressing changes/minor debridement) in patients with burn injury. it will be compared with a standard treatment regimen of oral morphine. the hypothesis is that the fentanyl spray will be more effective for the treatment of procedural pain in patients with burn injury.

Eligibility criteria:
inclusion criteria: * subject capable of giving consent * age 18-65 * total burn surface area greater than or equal to 5% * opioid tolerant * bmi less than or equal to 35 exclusion criteria: * subjects with cognitive or psychiatric impairment that would preclude study participation or compliance with protocol * allergy to fentanyl, morphine, naloxone * pregnancy, intent to become pregnant or lactating * evidence of burn injury to oral mucosa * active illicit drug use or illicit drug abuse history

Keywords: burn pain procedural pain sublingual fentanyl morphine
effects of two different physical therapy protocols after an endodontic intervention

Conditions: Root Canal Therapy; Endodontically Treated Teeth

Summary: the purpose of this study was to evaluate the clinical results produced by a manual therapy treatment combined with dry needling (mt+dn) and a manual therapy treatment (tm) versus a control (c), to normalize the altered cervico-mandibular variables after a session of root canal therapy.


Eligibility criteria:
inclusion criteria: * being over 18 years old and requiring an endodontic intervention. exclusion criteria: * have received tmj or cervical treatment during the last month, presented any red flag, neurological or cognitive impairment (inability to understand the questionnaires or examination).

Keywords: dry needling manual therapy temporomandibular joint cervical spine root canal therapy
osteostrux™ collagen ceramic scaffold in instrumented lumbar spine fusion

Conditions: Degenerative Changes; Stenosis; Spondylosis

Summary: the objective of this study is to prospectively evaluate the performance of integra's osteostrux collagen ceramic scaffold combined with bone marrow aspirate as an adjunct for instrumented posterolateral spine fusion, as compared to local autograft.


Eligibility criteria:
inclusion criteria: 1. are 18 (eighteen) years of age or older at the time of surgery. 2. require spinal fusion using tlif, plf or plif, with or without the use of an interbody spacer, at 1 to 3 levels between l3-s1. 3. are willing and able to return for the scheduled follow-up visits, follow post-operative instructions and undergo the required radiographic exams (a/p, lateral neutral and lateral flexion/extension x-rays) for up to 4 time points between 3 weeks and 12 months post-surgery (3 months ± 2 weeks, 6±1 months, 12±2 months and if required 24±3 months post-surgery), including one ct-scan at 12±2 months. 4. are unresponsive to conservative care over a period of at least 6 months or have signs and/or symptoms that mandate urgent surgical intervention. 5. are willing and able to sign study specific informed consent. exclusion criteria: 1. are long term users of medications (i.e. steroids greater than 8 days) that are known to inhibit fusion or bone metabolism at any time within 6 months prior to surgery. exceptions are inhaled steroids for asthma treatment (i.e. patients on inhaled steroids are allowed), or epidural steroid injections. 2. are taking immunosuppressive agents (cancer chemotherapy, treatment with disease modifying anti-rheumatic drugs (dmards) or any similar immunomodulating drugs) or are treated with growth factors or insulin at any time within 6 months prior to surgery. 3. are being treated with radiotherapy. 4. are having medical conditions, known to impact bone metabolism, such as paget's disease, or has established osteoporosis (i.e. has had one or more fragility fractures). 5. are pregnant, lactating or women wishing to become pregnant. 6. are a prisoner. 7. bmi ≥ 40 8. are smokers and/or nicotine/tobacco users 9. are currently participating in an investigational drug or another device study that has not completed the primary endpoint or that clinically interferes with the study endpoints. 10. had prior spine surgery at the index level except posterior decompressive surgery where the posterior elements are preserved e.g. facet saving techniques such as discectomy, laminotomy, and intradiscal procedures. 11. use of routine prophylactic nsaids for 3 months post-operatively, but low dose concomitant pain medications e.g. aspirin should be continued and recorded on the concomitant pain medications case report form (crf).
shared decision making and satisfaction with the diagnostic-therapeutic process in the shared decision making and satisfaction with colorectal cancer screening. the cydesa study

Conditions: Colorectal Cancer; Satisfaction, Patient

Summary: a cross sectional multicenter study (3 centers) to know the participation in decision making and the experience and satisfaction of participants with a positive immunological fecal test (fit) result in relation to the screening process and the diagnostic-therapeutic process of cancer. we will include 850 participants with a positive fit result and will classify them by their final diagnosis (false positives of fit; polyps; colo-rectal cancer). outcomes of interest will be measured by auto administered questionnaires: collaborate, sdm-q-9, out-patsat35 and a satisfaction questionnaire developed in a previous study.


Eligibility criteria:
inclusion criteria: * participants in the colorectal cancer screening program, with a positive result in the fit and in whom the perform of a colonoscopy is indicated and agree to be included exclusion criteria: * people for whom the performance of a colonoscopy is not indicated by medical reasons * people who refuse to perform a colonoscopy * people who do not understand spanish or catalan, with deterioration of the cognitive state that do not allow them to understand or answer the questionnaires on their own or with the help of a caregiver; * people in which the process is not carried out completely in the study centers (eg. performance of the colonoscopy in a private center).
elderly chronic diseases online biometric analysis home living technology

Conditions: The Elderly

Summary: the elderly or people with disabilities want to remain in their homes even when their health condition has been getting worse. this project aims to demonstrate that home automation and telemonitoring can lead to develop a home safety environment that could help the elderly and individual with disability live independently in their own home. in this study, the automation sensors containing devices follow up chronic disease clinical factors to monitor their biometrical parameters and detect any abnormal prodromal disease decompensation via telemonitoring and geriatric expertise. the purpose of this study is: * to provide clinical evidence of the effectiveness of automation tools and telemonitoring/expertise for the home support for people at risk of loss of autonomy * to demonstrate the clinical benefit of combining the automation and telemonitoring and geriatric teleexpertise


Eligibility criteria:
inclusion criteria: * aged 65 or more. * house equipped with home automation * having been hospitalized in the year prior to the inclusion for the following conditions : heart failure, chronic obstructive pulmonary disease (copd ), diabetes, high blood pressure ( hypertension ) , repetitive falls, chronic renal failure , stroke, neurodegenerative diseases , malnutrition (according to criteria has) * multiple chronic diseases (at least 2 comorbidities) . * having given free and informed consent exclusion criteria: * life expectancy less than 12 months * enrolled in another clinical trial

Keywords: elderly prevention multiple chronic disease telemonitoring geriatric teleexpertise home heath care medico-economics
prognostic analysis of concurrent chemoradiotherapy with/without adjuvant chemotherapy for locally advanced npc patients

Conditions: Local Advanced High Risk Nasopharyngeal Carcinoma

Summary: this is a randomized,controlled,prospective phase iii clinical trial. the purpose of this study is to evaluate acute toxicity and efficacy of concurrent cisplatin chemoradiation with or without capecitabine as adjuvant chemotherapy in local advanced nasopharyngeal carcinoma at high risk of distant metastasis.exploring an individualized comprehensive treatment plan which is reasonable,effective,low toxicity and fitting with modern radiotherapy techniques for local advanced nasopharyngeal carcinoma at high risk of distant metastasis.


Eligibility criteria:
inclusion criteria: * newly histologic diagnosis of nasopharyngeal carcinoma(who ii/iii) * clinical stage iii\~ivb(uicc/ajcc 7th) * no distant metastasis * karnofsky performance status scale≥70 * wbc count ≥ 4×109/l, neutrophil differential count≥ 1.5×109/l, hemoglobin ≥ 90g/l, platelet count ≥ 100×109/l * alt or ast ≤2.5×uln,bilirubin ≤2.5×uln, serum creatinine ≤1.5×uln or serum creatinine clearance≥60ml/min * sign the informed consent. exclusion criteria: * angle of sexual squamous cell carcinomas and basal cell layout, squamous cell carcinomas * younger than 18 years old or older than 70 years old * are receiving other drugs treanment * kidney disease * have suffered from other tumor or now suffering from other tumor * have recieved chemotherapy or radiotherapy * pregnancy or lactation * unstable heart disease need timely treatment * severe cerebrovascular disease/canker/psychosis/uncontrolled diabetes

Keywords: local advanced high risk nasopharyngeal carcinoma
safety and pharmacodynamics study of agn-207281 ophthalmic solutions compared with timolol ophthalmic solution or placebo in patients with ocular hypertension or primary open-angle glaucoma

Conditions: Glaucoma, Open-Angle; Ocular Hypertension

Summary: this is an exploratory study that will evaluate the safety and pharmacodynamics of up to 3 doses of agn-207281 based on an ongoing review of data during the study period compared with timolol ophthalmic solution or placebo in patients with ocular hypertension or primary open-angle glaucoma.


Eligibility criteria:
inclusion criteria: * ocular hypertension or primary open-angle glaucoma in each eye * requires iop-lowering therapy in both eyes * visual acuity score of 20/100 or better in each eye exclusion criteria: * experienced significant weight change (over 10 pounds) within 60 days * history of alcohol or drug addiction * history of migraines or frequent headaches * anticipated wearing of contact lenses during the study * required chronic use of ocular medications during study * eye surgery within 6 months * use of systemic beta blockers (eg, atenolol, propranolol) within 2 months * use of oral, intramuscular, intravenous corticosteroids within 21 days * use of ophthalmic corticosteroids within 2 months
covid-19: investigation of transmission and immunisation among hospital staff

Conditions: COVID

Summary: during the covid-19 pandemic several countries have seen a high risk of transmission for health care personnel, with some countries having as many 20-25% of nurses and doctors either infected or showing symptoms of covid-19. in this prospective cohort study, we will systematically screen all hospital staff in the capital region of denmark for igm and igg antibodies against sars-cov-2 using a point of care tests and an elisa kit. testing will be offered 3 times: in april 2020, maj 2020 and september 2020. all participants will submit a questionnaire regarding exposures, risk factors and symptoms of covid-19 in relation to each testing. follow-up will be through electronic patient records and national registries. we will compare the group of health care personnel with data from a control group of healthy volunteer blood donors from the danish blood donor study. the aim of the study is to investigate the proportion of hospital staff with sars-cov-2 antibodies during the study period compared to a control group representing the danish population. we will compare the test characteristics of the two methods of testing, a point of care test and elisa. further, we will investigate the extent to which prior immunization or infection is protective for future infection with covid-19.


Eligibility criteria:
inclusion criteria: * \>18 years old * consent to participation * employed at a hospital in the capitial region of denmark exclusion criteria: * none
restrictive versus liberal transfusion protocol in infants undergoing cardiac surgery

Conditions: Impaired Oxygen Delivery; Congenital Heart Disease

Summary: in neonates and infants \</= 10 kg following cardiac surgery for congenital heart disease a more restrictive red blood cell (rbc) transfusion strategy will be as effective as, and possibly superior to, a liberal rbc strategy. allowing lower hemoglobin concentration will not affect the cardiac or pulmonary status of the patient.


Eligibility criteria:
inclusion criteria: * children \</= 6 months of age with congenital cardiac disease undergoing cardiac surgery with cardiopulmonary bypass. exclusion criteria: * presence of a known bleeding disorder or coagulopathy. * age \> 6 months, * lack of informed consent.

Keywords: hemoglobin congenital heart disease cardiac surgery red blood cell transfusion number of red blood cell transfusions
robotic assisted major lung resection in elderly patients

Conditions: Lung Cancer

Summary: the study is a retrospective observational study. the study is designed to be multicentric and it will analyze medical records from selected patients that underwent major lung resection using davinci surgical platform performed in the participating centers. there are no risks for the patients, as this is a retrospective data collection.

the investigators will recruit all patients who underwent major lung resection (segmentectomy, lobectomy, bilobectomy, or pneumonectomy using a robotic system) from may 2015 to december 2022. patients are divided into two groups: older than 80 years (case- very elderly patients) and younger than 80 years (control- elderly). the aim: minimally invasive techniques such as robot-assisted thoracoscopic surgery (rats) can potentially reduce surgical trauma and therefore prove particularly beneficial for elderly patients.

Eligibility criteria:
inclusion criteria: * age \>18 years at the moment of surgery * suspected or confirmed diagnosis of lung cancer * the patient can be candidate in terms of cardiac, kidney, liver and respiratory function the primary pathology is under control or controllable * absence of extrapulmonary metastases that are not controlled or controllable * all procedures included use of davinci robot system exclusion criteria: * age \< 18 years at the moment of surgery * patients who cannot undergo surgery, as they do not meet the conditions outlined above

Keywords: robot-assisted thoracoscopic surgery lung resection
potential impact of the use of the application ventilo

Conditions: Mechanical Ventilation Complication

Summary: mechanical ventilation is a vital support associated with the treatment of patients with acute respiratory failure and in other indications such as surgery under general anesthesia, coma or shock. optimization of settings during mechanical ventilation and implementation of protective ventilation help to avoid ventilation-induced injury, ensure adequate oxygenation and maintain adequate carbon dioxide concentration to avoid respiratory acidosis or alkalosis. similarly, there is also no clear recommendation, to our knowledge, for the initial setting of the respiratory rate. therefore, initial settings are not always adequate and in the literature the frequency of respiratory acidosis is very high, reaching about half of the patients receiving mechanical ventilation. ventilo, is an application that is available on smart phones. this educational application provides clinicians with initial settings and optimization of these settings based on gender, height, weight, body temperature and patient type. the algorithm used is based on published data regarding ventilatory requirements in different populations and the anatomical and instrumental dead space of patients. the purpose of our study is to: 1. assess whether ventilatory settings after intubation are appropriate. 2. to compare the ventilatory adjustments made by clinicians with those proposed by the ventilo appalication.


Eligibility criteria:
inclusion criteria: * adults (\> or = 18 years old) * new endotracheal intubation exclusion criteria: * absence of arterial (or capillary) gas within two hours of intubation * absence of patient sizes available throughout the medical record