Kornimate/medical-research-clean huggingface dataset:
effect of iloprost on pulmonary oxygenation in patients with low diffusing capacity during one-lung ventilation

Conditions: Lung Cancer

Summary: one lung ventilation (olv) is essential during thoracic surgery. during olv, intrapulmonary shunt can be increased resulting hypoxemia. although olv technique had been advanced so far, hypoxemia during olv reaches about 10% in spite of inspired oxygen fraction 100%. iloprost is a prostaglandin analogue used for pulmonary hypertension, which can decrease pulmonary artery resistance by selectively dilating pulmonary artery. in this prospective, randomized, double blind study, investigators are planning to investigate the effects of iloprost on respiratory physiology (intrapulmonary shunt, deadspace, oxygenation, etc).


Eligibility criteria:
inclusion criteria: * scheduled for video-assisted thoracoscopic surgery (vats) lobectomy * 40 \< age \< 80 * american society of anaesthesiologists (asa) physical status classification i\~iii * diffusing capacity (dlco) \<75% at pre op. pulmonary function test exclusion criteria: * american society of anaesthesiologists (asa) physical status classification iv * new york heart association (nyha) class iii\~iv * severe obstructive lung disease and/or restrictive lung disease patients * patients with end-organ diseases (i.e. heart failure, respiratory failure, hepatic failure, renal failure) * arrhythmia * pregnant women * disease that can influence the dlco result (anemia, pulmonary vascular disease)
smart phone as a screening and evaluation tool to identify knee valgus during dynamic activities

Conditions: Leg Injuries

Summary: evidence supports the use of two dimensional video analysis to assess the presence of dynamic knee valgus during generally used screening tasks, however there is limited evidence to support the use of the various smart phone applications as a time and money saving option for clinic use . subjects that present to the clinic and display dynamic valgus at the knee during the lateral step down test will be given the option to participate in the study. if they consent to the study they will be evaluated with 2-dimensional video analysis to determine the amount of valgus present at the knee during the lateral step down test. the subject will also have the smart phone attached to their lower leg and the amount of valgus will be concurrently measured by the selected application. the primary objective of this study is to determine the validity of an application on the smart phone to provide an objective measure of dynamic knee valgus. the secondary objective of this study is to determine the possibility of the use of the application as a source of feedback during neuromuscular re-education training in order to decrease or eliminate a subject's dynamic valgus collapse and subsequently decreased their risk for future injury.


Eligibility criteria:
inclusion criteria: * willingness to participate * ability to perform a single leg squat, drop jump, and single leg drop without pain exclusion criteria: * lower extremity injury within 6 months prior to testing * history of lower extremity surgery * lower extremity weight bearing restrictions * inability to follow directions * neoprene/latex allergy * adhesive allergy * current neurological or developmental condition * inability to attend follow-up session * actively receiving physical therapy intervention for varus/valgus impairment * current pregnancy
the role of genetic factors in the development of epilepsy in the kazakh population

Conditions: Epilepsy

Summary: this is a gwas study that aims to identify possible candidate genes associate to epilepsy by exploring single nucleotide polymorphism (snp) in a group of epilepsy, in the kazakh population. the investigators hypothesize that the careful phenotyping of the subject sand matching with increase the power to find snp significantly associate with epilepsy

a genome-wide association study (gwas) is an approach used in genetics research to associate specific genetic variations with particular diseases. the method involves scanning the genomes from many different people and looking for genetic markers that can be used to predict the presence of a disease. once such genetic markers are identified, they can be used to understand how genes contribute to the disease and develop better prevention and treatment strategies

Eligibility criteria:
inclusion criteria: * children with seizures, confirmed by eeg and no morphological damage to the brain, confirmed by mri of the brain; * the age of the patients is from 0 to 5 years; * persons of kazakh nationality, whose paternal and maternal grandparents are kazakhs; * children are parents or legal guardians who have given written informed consent. exclusion criteria: * children over 5 years old; * children whose parents, according to the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent; * children with seizures with brain damage that cause epilepsy; * children of a non-kazakh ethnic group.

Keywords: gwas
exercise in anxiety and posttraumatic stress disorders

Conditions: Anxiety

Summary: aim: aerobic and resistance exercise showed anxiolytic effects in clinical populations. climbing could further enhance self-efficacy. aim of the study is to examine whether climbing exercise and aerobic exercise, compared to social contact control, reduces symptoms of disease in out-patients with anxiety disorder (ad) and post-traumatic stress disorder (ptsd). further analyses are aiming to reveal differences between climbing - and aerobic exercise. design: randomized controlled clinical trial participants: thirty out-patients diagnosed with international classification of disease-version 10 (icd-10) (f40, f41, f43.1) for ad or ptsd. intervention: out-patients will be assigned randomly to a climbing exercise group (a), aerobic exercise group (nordic walking) (b) or social contact control group (c). measurements: primary outcome is symptom severity in ad or post traumatic stress disorders. further secondary outcomes are evaluated by psychological questionnaires assessing depression, worry symptoms, quality of life, self-efficacy and affective responses. metabolites of neurotransmitters, immune-activation markers and anthropometric data will be additionally provided as secondary physiological outcomes. duration: intervention duration is four weeks with 2 x 75 min for every group (climbing exercise, aerobic exercise, social contact control). measurement points are set at the beginning (t1), at the end of the intervention (t2) and 3 (t3) and 6 (t4) months follow-up.

the proposed research project is designed as a randomized controlled clinical trial with three arms. the efficacy of a climbing exercise program, an aerobic exercise program and a social contact control group on primary and secondary study outcome will be investigated (see figure 1). patients will be first screened by the outpatient-unit of the department of psychosomatics at the medical university of innsbruck or remitted through the treating staff network community. when assessed as eligible for the study, a group of up to ten out-patients will be randomly selected and invited to an informative meeting. patients receive study information and time tables for their group attendances. the intervention will start within the following week and will end four weeks after beginning. follow-up assessments will take place three and six months after intervention. in addition to the ad/ptsd symptom screening, secondary study outcomes will be assessed: * at study inclusion (t1) * at the end of the intervention (t2) * three months after the intervention (t3) * six months after the intervention (t4)

Eligibility criteria:
inclusion criteria: * icd-10 diagnosis of anxiety disorder or post traumatic stress disorder: f40, f41, f43.1; * age range: 18-65 * written informed consent * stable medication (if needed) for at least 3 weeks exclusion criteria: * acute psychosis or suicidal behaviour * medical contraindication to physical activity (assessed by a clinician) * cognitive deficits * problems with german language

Keywords: anxiety disorder posttraumatic stress disorder sports intervention
effects of spironolactone on cardio- and cerebrovascular morbidity and mortality in hemodialysis patients

Conditions: End-stage Renal Failure

Summary: aldosterone receptor blockers reduce cardiac-related morbidity and mortality. recently, we demonstrated that long-term low-dose spironolactone is clinically safe in many hemodialysis (hd) patients. in the present study, we assess whether low-dose spironolactone treatment reduces the high incidence of cardio- and cerebrovascular (ccv) morbidity and mortality in hd patients. the investigators' hypothesis is that aldosterone receptor blockade by spironolactone reduces the risk of both ccv morbidity and death among hd patients.


Eligibility criteria:
inclusion criteria: * hemodialysis patients undergoing 4-hour-long hd thrice a week for at least 2 years * with an average serum potassium level (immediately before dialysis on the first day of the week) of \<6.5 meq/l over the previous 2 months * with a 24-hour urine output of \<500 ml exclusion criteria: * a history of noncompliance * unstable vascular access * hypotension * hepatic failure * active cancer * any life-threatening disease other than esrd

Keywords: cardiovascular event hemodialysis spironolactone
role of glucagon-like peptide-1 in postprandial hypoglycemia

Conditions: Postprandial Hypoglycemia

Summary: it has been proposed that the rapid gastric emptying of carbohydrate containing fluids into the intestine causes hyperglycemia followed by reactive hypoglycemia. the investigators have shown that glucagon-like peptide-1 (glp-1) secretion in response to a glucose load is increased in children with post-prandial hypoglycemia (pph). this is a proof of concept study to investigate the causative role of glp-1 in the pathophysiology of pph after fundoplication by evaluating the effects of glp-1 receptor antagonism on metabolic variables after a mixed meal. hypothesis: in children with post-prandial hypoglycemia after fundoplication, antagonism of the glp-1 receptor by exendin-(9-39) will elevate nadir blood glucose levels after a meal challenge and prevent post-prandial hypoglycemia.

pph is a frequent complication of fundoplication in children. the mechanism responsible for the pph is poorly understood, but involves an exaggerated insulin response to a meal and subsequent hypoglycemia. we have shown that children with pph after nissen fundoplication have abnormally exaggerated secretion of glp-1, an incretin hormone with multiple glucose lowering effects including stimulation of insulin secretion and suppression of glucagon secretion. in this study we seek to examine the causal role of endogenous glp-1 in pph after fundoplication by evaluating the effects of antagonizing the glp-1 receptor with exendin-(9-39) on key metabolic features of pph.

Eligibility criteria:
inclusion criteria: * children (6 months-18 years) who have had fundoplication or other gastric surgeries, irrespective of duration of postoperative period * weight \> 6.5 kg * signs and/or symptoms of pph: post-prandial blood glucose levels of \< 70 mg/dl ; symptoms including but not limited to feeding difficulties, irritability, nausea, diarrhea, pallor, diaphoresis, weakness, and lethargy after meals exclusion criteria: * evidence of a medical condition that might alter results or compromise the elimination of the peptide, including, but not limited to: active infection, kidney failure (creatinine ≥ 2x above upper limit for age), severe liver dysfunction (ast or alt ≥ 5x upper limit of normal for ast or alt), severe respiratory or cardiac failure * other disorders of glucose regulation such as diabetes mellitus, congenital hyperinsulinism, glycogen storage disease * current use (within 1 week) of medications that may alter glucose homeostasis such as glucocorticoids, diazoxide, octreotide * use of antihistaminics within 10 days prior to the study * moderate and severe anemia defined as a hemoglobin \< 10g/dl * pregnancy * milk and soy protein allergy

Keywords: post prandial hypoglycemia hypoglycemia nissen fundoplication dumping
deep learning algorithm for the diagnosis of gastrointestinal diseases depending on tongue images

Conditions: Gastrointestinal Disease

Summary: the purpose of this study is to analysize the relationship between the characteristics of tongue image and the diagnosis of gastrointestinal diseases , then develop and validate a deep learning algorithm for the diagnosis of gastrointestinal diseases depending on tongue images, so as to improve the objectiveness and intelligence of tongue diagnosis. at the same time, gastrointestinal flora of common tongue images were analyzed in order to provide a microecological basis for understanding the relationship between tongue images and digestive tract diseases.

tongue diagnosis is an important part of traditional chinese medicine.according to traditional chinese medicine theory,health condition can assessed by observing tougue features,including color, gloss, shape and coating of the tongue, tongue features reflect gastric mucosal state, disease classification and prognosis. recently, deep learning based on central neural networks (cnn) has showntongue diagnosis is an important part of traditional chinese medicine.according to traditional chinese medicine theory,health condition can assessed by observing tougue features,including color, gloss, shape and coating of the tongue, tongue features reflect gastric mucosal state, disease classification and prognosis. recently, deep learning based on central neural networks (cnn) has shown multiple potential in detecting and diagnosing gastrointestinal diseases. however, there is still a blank in recognition of gastrointestinal diseases .this study aims to develop and validate a deep learning algorithm for the diagnosis of digestive tract diseases depending on tongue images,and analyze gastrointestinal flora of common tongue images.

Eligibility criteria:
inclusion criteria: * patients aged 18 - 80 years undergoing endoscopic examination;patients gave informed consent and signed informed consent. exclusion criteria: -

Keywords: gastrointestinal disease tongue image artificial intelligence deep learning gastrointestinal flora
neuwave flexible probe study #2

Conditions: Cancer of the Lung; Lung Cancer; Neoplasms, Lung; Carcinoma, Non-Small Cell Lung; Non-Small Cell Lung Cancer; Non-Small Cell Lung Carcinoma

Summary: patients with medically inoperable and operable secondary soft tissue lesion(s) of the lung will have transbronchial microwave ablation performed using cone beam ct for probe guidance and confirmation.

adult patients with medically inoperable and operable secondary soft tissue lesion(s) of the lung less than 2cm will undergo transbronchial microwave ablation performed by an interventional pulmonologist or thoracic surgeon using cone beam ct imaging for probe guidance and confirmation on ablation outcome. all treated patients will be followed for one year following the ablation procedure for efficacy and safety.

Eligibility criteria:
inclusion criteria: 1. signed informed consent 2. patients greater or equal to 18 years of age 3. performance status 0-2 (eastern cooperative oncology group classification \[ecog\]) 4. willing to fulfill all follow-up visit requirements 5. medically inoperable and operable secondary soft tissue lesion(s) of the lung 6. a maximum of two ipsilateral soft tissue lesions less than or equal to 2cm in the outer two-thirds of the lung and not closer than 1cm to the pleura. lesion size must be measured with at least 2-dimensional imaging. exclusion criteria: 1. scheduled concurrent procedure for the target soft tissue lesion(s) other than those that are lung-related 2. pregnant or breastfeeding 3. physical or psychological condition that would impair study participation 4. patients with uncorrectable coagulopathy at the time of screening 5. patient with implantable devices, including pacemakers or other electronic implants 6. prior pneumonectomy or bronchiectasis 7. severe neuromuscular disease 8. patient count less than or equal to 50,000/mm cubed 9. asa (american society of anesthesiologists) score of greater than or equal to 4 10. inability to tolerate anesthesia 11. expected survival less than 6 months 12. clinically significant hypertension 13. chronic, continuous ventilator support, which uses bi-level positive airway pressure (pap) to improve lung function for severe conditions (however, intermittent pap, for non-pulmonary conditions, such as sleep apnea, is permitted) 14. endobronchial soft tissue lesions proximal to the segmental airways 15. imaging findings of active pulmonary infection 16. the patient was judged unsuitable for study participation by the investigator for any other reason.

Keywords: microwave ablation
evaluation of the effect of botulinum toxin type-a injection prior to surgical correction of complete unilateral cleft lip repair by modified millard cheiloplasty

Conditions: Esthetic Outcome of Injection of Botulinum Toxin Type-A in Cleft Lip Repair

Summary: evaluation of the effect of botulinum toxin type-a injection prior to surgical correction of complete unilateral cleftlip repair by modified millard cheiloplasty


Eligibility criteria:
inclusion criteria: * primary cleft lip exclusion criteria: * cleft palate
rhomboid flap versus primary closure after excision of sacrococcygeal pilonidal sinus. (a prospective randomized study)

Conditions: Evaluate and Compare Between Excision and Primary Closure Procedure and Rhomboid Flap Technique for the Treatment of Pilonidal Sinus; Duration of Operation,

Summary: to evaluate and compare between excision with primary closure of wound and excision with rhomboid flap reconstruction in the treatment of pilonidal sinus as regard duration of operation, healing time, hospital stay, complications and recurrence rate.


Eligibility criteria:
inclusion criteria: * chronic pilonidal sinus exclusion criteria: * pilonidal abcess

Keywords: pilonidal disease natal cleft limberg flap
high-impact exercise in adults with crohn's disease

Conditions: Crohn Disease

Summary: crohn's disease increases the risk of poor musculoskeletal health, as the inflammatory disease process directly inhibits regulatory pathways involved in bone and muscle formation and maintenance. the negative effects of disease on muscle-bone health are compounded by poor nutritional status, vitamin d deficiency, prolonged exposure to glucocorticoid therapy, and reduced physical activity. modern, steroid sparing therapies are successful at inducing clinical remission in terms of inflammation, however they have limited effect in remedying observed muscle-bone deficits. subsequently, patients with crohn's disease are at increased lifelong risk of pathological fractures and osteoporosis. novel adjunctive therapies are therefore required to complement pharmacological treatments and target muscle-bone deficits, which are responsible for significant disease burden in crohn's. high-impact exercise may be a useful additional therapy for patients with crohn's disease, as the mechanical strains produced during this type of exercise, through large magnitude muscular contractions and ground reaction forces, can promote bone formation and gains in muscle mass. there have been no previous studies assessing the effects of high impact exercise in crohn's disease, so it is unknown if this type of exercise is safe and feasible in this population. the aim of this study is to assess the feasibility of high-impact exercise for improving markers of bone and muscle health in adults with crohn's disease, and compare the effects of exercise with a group of healthy age and sex matched controls.


Eligibility criteria:
inclusion criteria: * crohn's disease diagnosed at least six months ago * stable medication for at least four weeks * disease in remission, or mildly/moderately active according to harvey bradshaw index score * currently undertaking \<2 hours of structured exercise per week * able to mobilise and exercise independently * able to provide written informed consent exclusion criteria: * surgery \<12 weeks or planned surgery during intervention period * comorbidity known to affect muscle / bone * contraindication to high-impact exercise * pregnancy or planned pregnancy during intervention period * bmi \>40 kg/m2 (or body mass \>120kg)

Keywords: crohn's disease exercise feasibility
crossmodal learning in therapeutic processes (task 2-1)

Conditions: Stroke

Summary: interventional study of the effects of vibro-tactile feedback on behavioral deficits and learning during motor training in patients with stroke.


Eligibility criteria:
inclusion criteria: * ischemic stroke according to icd 10 i61-i69 * deficit still existing (rankin score of at least 1 at inclusion) * age \>= 18, \<=80 * existing declaration of consent exclusion criteria: * pregnancy * lacking capacity for consent

Keywords: vibro-tactile stimulation neurorehabilitation stroke
efficacy of a smart water bottle intervention to increase fluid consumption in college students

Conditions: Dehydration

Summary: approximately 60% of males and 40% of females do not meet current fluid intake recommendations, which is associated with adverse health consequences such as obesity, diabetes, and chronic kidney disease. newer technologies have been designed to promote fluid intake. "smart water bottles" use mhealth technology to capture fluid intake behaviors automatically and provide cues to encourage fluid consumption. studies using smart water bottles have helped some individuals increase fluid intake to help reduce kidney stone formation. however, limited research has assessed the efficacy of this technology on improving fluid intake in college students. college is a time with the potential to form healthy habits that carry into adulthood. previous work has also identified daily changes in morning urine color, thirst perception, and body mass, as simple, inexpensive indicators of daily fluctuations in water balance. tracking changes in these metrics has the potential to provide participants with evidence of adequate or inadequate fluid consumption. thus, the combination of prompting from a smart water bottle, as well as daily self-monitoring changes in hydration status, may encourage college students to increase daily fluid consumption.


Eligibility criteria:
inclusion criteria: * participants must report currently drinking less than the european food safety authority recommendations for fluid, as determined by an online pre-screening survey (\<2.5 l per day for males; \<2.0 l per day for females). * has access to a cell phone which can download the app associated with the smart water bottle. exclusion criteria: * currently trying to gain or lose weight * have had surgery of the digestive tract * currently taking diuretics (e.g., thiazide, loop diuretics or potassium-sparing diuretics) * currently taking centrally-acting medications (e.g., anesthetics, anticonvulsants, central nervous system stimulants/amphetamines, muscle relaxants) * report currently consuming at least the european food safety authority recommendations for fluid, as determined by an online pre-screening survey (\>= 2.5 l per day for males, \>=2.0 l per day for females). * currently pregnant (females)

Keywords: underhydration copeptin urine water