Kornimate/medical-research-clean huggingface dataset:
pet imaging using 64cu-tz-sarar and hu5b1-tco in people with pancreatic, colorectal, bladder cancer or cancers with elevated ca19.9

Conditions: Pancreatic Cancer; Pancreatic Ductal Adenocarcinoma; Metastatic Pancreatic Ductal Adenocarcinoma; Primary Pancreatic Ductal Adenocarcinoma; Metastatic Pancreatic Cancer

Summary: the purpose of this study is to find the highest safe dose of hu5b1-tco and the best dosing schedule of hu5b1-tco and 64cu-tz-sarar for finding cancer cells that are ca19-9 positive. this study will also help to find out how much radiation the body is exposed to when 64cu-tz-sarar is used, and provide information on the way the body absorbs, distributes, and gets rid of 64cu-tz-sarar.


Eligibility criteria:
inclusion criteria: patients will be eligible for enrollment if they fulfill the following criteria: 1. signed informed consent 2. 18 years of age or older 3. histologically confirmed primary or metastatic pancreatic ductal adenocarcinoma/bladder carcinoma / gastrointestinal tumor reviewed at msk - includes patients with biopsy-proven or high suspicion on imaging for pancreatic ductal adenocarcinoma (pdac) or histologically confirmed, locally-advanced, or metastatic pancreatic ductal adenocarcinoma (pdac) of patient with solid tumors increased serum ca19-9 serum level greater than uln or ca19-9 positive biopsy 4. at least one lesion by ct or mri ≥ 2 cm unless determined otherwise for presurgery subjects 5. ecog performance status of 0 to 2 6. adequate laboratory parameters including: i. absolute neutrophil count (anc) ≥1.5 x 109/l ii. hemoglobin ≥ 9.0 g/dl iii. platelet count \>75,000/ mm3 iv. ast/sgot, alt/sgpt ≤2.5 x uln, unless liver metastases are clearly present, then ≤5.0 x uln v. total bilirubin ≤ 1.5x the upper limit of normal unless considered due to gilbert's syndrome in which case, ≤3x the upper limit of normal vi. creatinine clearance (clcr) (\> 60 ml/min) estimated by the cockcroft-gault (c-g) equation or estimated glomerular filtration rate (egfr) 10. willingness to participate in collection of pharmacokinetic samples exclusion criteria: patients will be excluded from the study if they fulfill any of the following criteria: 1. active, uncontrolled bacterial, viral, or fungal infection(s) requiring systemic therapy 2. major surgery other than diagnostic surgery within 4 weeks of study day 1 3. history of anaphylactic reaction to human, or humanized, antibody 4. other on-going cancer therapy with investigational agents 5. known history of hiv 6. pregnant or currently breast-feeding a. subjects and their partners with reproductive potential must agree to use an effective form of contraception during the study and for 1 week following the study treatment. 7. psychiatric illness/social situations that would interfere with compliance with study requirements.

Keywords: pancreatic cancer pancreatic ductal adenocarcinoma metastatic pancreatic ductal adenocarcinoma primary pancreatic ductal adenocarcinoma metastatic pancreatic cancer hu5b1-tco 64cu-tz-sarar 20-409 memorial sloan kettering cancer center
textbook outcomes after oesophagectomy in regional australia

Conditions: Oesophageal Cancer Nos

Summary: the goal of this observational cohort study is to assess textbook outcomes after oesophagectomy in a regional australian hospital. this is a composite quality measure that include 9 parameters related to cancer care. researchers will compares the textbook outcome rate in this regional hospital and compare it to textbook outcomes rates from other australian hospitals, as well as hospitals overseas. participants will not be actively involved in this study, as all data will be collected from medical records only.

rationale textbook outcomes is a composite tool to assess the quality of cancer care within an institution by evaluating several perioperative and postoperative factors. most studies assessing textbook outcomes after oesophagectomy have been conducted in high-volume centres, achieving rates of up to 50%. to the best of our knowledge this is the first study to assess textbook outcomes after oesophagectomy in a regional australian hospital, providing a unique insight into the performance of this procedure in a country that has not widely adopted centralisation of cases. aims/objectives to calculate textbook outcomes rates in a regional hospital in australia and compare to higher volume australian and international institutions. methods retrospective identification of patients from mbs codes related to oesphagectomy, and collection of data retrospectively from the medical record only. all patients undergoing oesophagectomy from january 2014 to december 2023 will be included. there are no exclusion criteria. data collection baseline patient characteristics, tumour-specific factors, textbook outcome parameters, treatment details including postoperative complications, and follow up data on survival will be collected statistical analysis statistical analysis will be performed in consultation with a biostatistician. the number and proportion of patients who meet each parameter of the textbook outcome will be calculated for each year and compared. patient characteristics (age, gender, bmi and asa grade), tumour factors (histology, ajcc clinical t and n stage), and treatment aspects (neoadjuvant therapy and surgical approach) will be assessed for association with textbook outcomes using the chi squared test with significance considered less than 0.05. a kaplan-meier survival curve will be used to investigate overall survival of patients with and without a textbook outcome.

Eligibility criteria:
inclusion criteria: * all patients who underwent oesophagectomy between january 2014 and december 2023 exclusion criteria: * none

Keywords: oesophagectomy oesophageal cancer regional surgery
regional anesthesia to reduce opioid use following functional endoscopic sinus surgery

Conditions: Pain Management

Summary: opioids are prescribed for moderate to severe pain disorders; however, there are contraindications and side effects that are common to all opioids. the investigators hypothesize using regional anesthetic during sinus surgery will reduce surgical pain, therefore decreasing the need for post-operative opioid medication. the primary of objective is to determine if a long-acting local regional anesthetic applied during a surgery will reduce post-operative oral opioid usage.

opioid analgesics are prescribed for moderate to severe acute pain; however, there are contraindications, cautions, and side effects that are common with all opioids. dependence and tolerance are also likely with regular opioid use, resulting in the current nationwide opioid epidemic. in alabama alone, there were 343 opioid-related overdose deaths in 2016, 124 of which were related to prescription opioids. alabama providers have the highest prescribing rate in the country, nearly twice the national rate, per the nih/nida website. in 2015, the centers for disease control (cdc) released prescribing guidelines relating to chronic pain, and in 2018 alabama's blue cross/blue shield insurance group limited the supply of opioids allowed to their members to 7 days. there is currently no clinical guideline for prescribing post operative opioid medications for functional endoscopic sinus surgery (fess). a 2018 survey documenting prescribing patterns by 168 members of the american rhinologic society found that most physicians who participated prescribed, on average, 27 opioid pain pills for patients after surgery. prior studies have been performed to help decrease the pain patient's feel after sinus surgery. haytoglu in 2016 revealed that adding non-absorbable sinus packs loaded with local anesthetics such as bupivacaine achieved less pain values and improved patient satisfaction scores. given this current data the investigators believe injecting patients with a long acting analgesic during the procedure will help reduce post-operative pain. if the investigators can decrease the amount of pain patients have in the post-operative period, they can theoretically decrease the number of opioid pain pills prescribed. the investigators plan to also track the number of opioid pills consumed by patients in the post-operative period to obtain a somewhat uniform prescribing pattern within surgeons.

Eligibility criteria:
inclusion criteria: * age 18 years or older * able to sign informed consent form * able to comply with all study procedures and availability for the duration of the study * able to speak english * diagnosis of chronic rhinosinusitis * scheduled to receive functional endoscopic sinus surgery (fess) at uab exclusion criteria: * current use of opioid medication * known allergic reactions to components of the study intervention * history of iv drug use or abuse * history of opioid abuse * history of chronic pain disorder * treatment with another investigational drug or other intervention within 30 days
theory of mind in preschool children, school children, youths and adults born preterm or full-term

Conditions: Premature Birth

Summary: this study tests preschoolers, school children, youths and young adults, who were born preterm or full-term, in their theory of mind abilities.

is there any difference in the development of theory of mind between preterms and full-terms? is there a risk group of preterms to develop a deficit in theroy of mind? four groups are tested: prescoolers (again two years later), youths and young adults. all participants were tested for theory of mind, executive functions, language and cognitive abilites.

Eligibility criteria:
inclusion criteria: * informed consent * preterm: birthweight \<1500g * full-term: born after 38 weeks exclusion criteria: * no informed consent

Keywords: theory of mind very low birthweight infants
sleep apnea treatment after stroke (sats)

Conditions: Obstructive Sleep Apnea; Stroke

Summary: the purpose of this study is to determine if treating stroke patients who have obstructive sleep apnea with continuous positive airway pressure will improve symptoms caused by the stroke.

stroke is the leading cause of adult disability in the united states, yet there are very few treatments that improve stroke outcome. obstructive sleep apnea (osa)--frequent upper airway blockage that occurs during sleep--is common after stroke, affecting more than half of stroke patients. the most common treatment for obstructive sleep apnea in the general population is nasal continuous positive airway pressure (cpap) applied through a nasal mask during the hours of sleep. positive air pressure holds the naso-oro-pharyngeal airway open during sleep. the objective of this single-center, prospective, randomized study is to evaluate cpap treatment in post-stroke patients. participants will go through a medical interview, a brief neurological examination, and a sleep study to screen them for osa. those with osa will be eligible for the second phase of the study during which participants will be randomly selected to receive either treatment with cpap or with sham cpap (placebo). this project promises to establish feasibility, develop design and identify suitable outcome measures (e.g. hours of cpap treatment per week, functional outcome, depression, fatigue, and impaired alertness) for a large-scale clinical trial of cpap in stroke patients with osa. if the larger trial shows benefits of cpap, a new treatment for more than half of all stroke patients will become available.

Eligibility criteria:
inclusion criteria: * ischemic stroke within 7 days of planned polysomnography/sleep screening study * modified rankin scale score \>1 * if of child-bearing potential, has a negative urine or serum pregnancy test exclusion criteria: * decompensated heart failure * cardiac or respiratory arrest within the past 3 months * myocardial infarction within the past 3 months * severe pneumonia * hypertension refractory to treatment * any other unstable medical condition which is thought to interfere with participation * known preexisting osa already on cpap or previously failed cpap or used cpap * previous pneumothorax * bullous emphysema * chronic obstructive pulmonary disease (copd), obesity-hypoventilation, or another condition warranting the use of nasal bilevel positive airway pressure instead of cpap * acute sinus or ear infection

Keywords: obstructive sleep apnea stroke osa cpap continuous positive airway pressure
multicenter validation of the predict score

Conditions: Rectal Cancer

Summary: even after adequate tme with grade iii mesorectal grading, local recurrence remains a possible event. several studies investigated different parameters and assessed their predictive power in regards to local recurrence after tme. these parameters included a variety of patient-related, tumor-related, and treatment-related factors. a recent meta-analysis reviewed the current literature for the predictors of local recurrence after tme for rectal cancer and developed a prognostic scoring system, the predict score. the present study aimed to validate the predict scoring system by applying it to a prospective cohort of patients with rectal cancer who underwent curative tme in three


Eligibility criteria:
inclusion criteria: * adult patients of either sex with non-metastatic low or middle rectal cancer who underwent elective tme with curative intent exclusion criteria: * patients with recurrent or metastatic rectal cancer at the time of presentation * patients with synchronous colon cancer * patients with missing data on the outcome of tme.
pd-1 knockout engineered t cells for advanced esophageal cancer

Conditions: Esophageal Cancer

Summary: this study will evaluate the safety of pd-1 knockout engineered t cells in treating advanced esophageal cancer. blood or tissue samples will also be collected for research purposes.

this is a prospective clinical study of ex-vivo selected, engineered, and expanded pd-1 knockout t cells from autologous origin. 16 advanced esophageal cancer patients are planned to receive two cycles of pd-1 knockout engineered t cells infusion. immunological markers are analyzed as well.

Eligibility criteria:
inclusion criteria: * histologically confirmed recurrent or metastatic esophageal cancer * measurable disease * progressed after standard treatments * ecog performance status of 0-2 * expected life span: \>= 3 months * toxicities from prior treatment has resolved or ≤ grade 1 * major organs function normally * women at pregnant ages should be under contraception * willing and able to provide informed consent exclusion criteria: * other malignancy within 5 years prior to entry into the study, expect for treated non-melanoma skin cancer and cervical carcinoma in situ * poor vasculature * disease to the central nervous system * blood-borne infectious disease, e.g. hepatitis b * history of mandatory custody because of psychosis or other psychological disease inappropriate for treatment deemed by treating physician * with other immune diseases, or chronic use of immunosuppressants or steroids * pregnancy (women of childbearing potential:refusal or inability to use effective means of contraception) * breastfeeding * decision of unsuitableness by principal investigator or physician-in-charge

Keywords: esophageal cancer immune checkpoint pd-1 crisper autologous cell infusion
expanded access use of incb054329 to treat a single patient with metastatic renal cell carcinoma


Summary: expanded access use of incb054329 to treat a single patient with metastatic renal cell carcinoma.


Eligibility criteria:
inclusion criteria: - exclusion criteria: -
the influence of parental behavior on the course of the pediatric dentistry session

Conditions: Behavior, Child; Parents; Dental Anxiety

Summary: the aim of the experiment is to analyze the impact of the behavior of the accompanying parent on the behavior of the child during a first dental session according to the age group.

i will receive the children for consultation at the chu saint pierre - césar de paepe site, to assess the impact of parents' behavior on the child. first, i will make a first contact with the child in the waiting room using the corah scale (self-assessment based on diagrams) which will allow him to assess his temperament in the face of dental care. . then, i will have the parents / caregiver sign informed consent and authorization to film. once the child enters the practice, the video recording will be initiated: the installation on the seat, the confidence building and the care provided will be filmed. these videos will then be analyzed by several practitioners from different categories (experts in pedodontics, general dentists, dental students, etc.) using the venham hetero-assessment scale modified for the behavior of the child and of a scale of parental cooperation. these practitioners will be selected via the adub (association of dentists of université libre de bruxelles) and some of them could be external to the hospital. following this study, the results obtained will be described and statistically analyzed.

Eligibility criteria:
inclusion criteria: * be in the correct age group and agree to participate in the study exclusion criteria: * not be in the right age group, refuse to participate in the study
postmarketing surveillance study of atrovent® in chronic obstructive airways disease

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: study to obtain further information on the tolerability and efficacy of atrovent® unit dose vial 500 µg in the treatment of chronic obstructive airways disease under conditions of daily practice


Eligibility criteria:
inclusion criteria: * primarily patients of both gender, older than 30 years, who suffer from chronic obstructive airways disease * only patients who had not been treated with atrovent® within the last year were to be considered for inclusion exclusion criteria: * contraindication listed in the instructions for use/summary of product characteristics for atrovent® unit dose vial 500 µg
per-operative radiotherapy by papillon +tm in localized breast cancer

Conditions: Localized Breast Cancer

Summary: phase ii study; open recruitment, multicentrique. the aim of this clinical research is to evaluate faisability and toxicity of the per-operative radiotherapy using papillon + tm device for localized breast cancers patients over 65 years.


Eligibility criteria:
inclusion criteria: * patient with invasive ductal adenocarcinoma \<=2cm, evaluate on all radiological exams; * women aged 65 years or older (patients 65 years of age in the year may be included); * grade 1 or 2 unifocal adenocarcinoma, all index ki67, positive hr, negative her2 status; * t0 or t1, n0 radio-clinic; * operable patient with breast volume compatible with conservative surgery; * patient with prior malignancy or other concurrent malignancies are eligible, including bilateral breast cancer * patients who have been made aware of the information sheet and have given their written signed informed consent; * patients benefitting from social health insurance coverage exclusion criteria: * age less than 65 years (except if 65 years obtained during the year) * patient with an exclusive in situ carcinoma * patient with lymphatic invasion / peri-nerve involvement / vascular emboli * patient with a lobular adenocarcinoma * patient with metastatic disease * multifocal tumor * patient with grade 3 or n+ disease * n1 proved by ultrasound guided * patient unable to express her consent * patient deprived placed under the authority of a tutor * female patients who are pregnant or breastfeeding * vulnerable patient: as defined in article l1121-5 à -8
project chill: tailored youth drug intervention in primary care

Conditions: Marijuana Use

Summary: this study examines the impact of tailored computer-delivered and therapist-delivered brief motivations prevention/interventions both for adolescents who have not initiated marijuana use (prevention), and those who use marijuana (intervention). key moderators of prevention/intervention effectiveness will be examined, including behavioral intentions, self-efficacy, stage of change, school involvement, susceptibility to peer pressure, and potential health consequences such as std/hiv risk behaviors. this project will provide the critical first step toward the development and implementation of marijuana use prevention/intervention programs that have the potential to be delivered to a large segment of youth who seek care in our nation's primary care settings.

the primary care setting represents an underutilized venue for prevention interventions addressing drug use/abuse among youth. the purpose of the study is to: (1) develop and refine promising, empirically-derived, bmi prevention/intervention modules delivered by a clinician or a computer to target marijuana use, and (2) test the effectiveness of bmi in preventing initiation/escalation of marijuana use among youth in community health clinics. this randomized controlled trial screened adolescents in primary care clinics in flint, mi. a random sample of those who screened negative for past year marijuana use were selected to participate in the study and all subjects who screened positive for past year use were enrolled in the study. these subjects were stratified by gender, age, and past year marijuana use and randomized to one of three conditions: 1) computer-delivered brief motivational approach (bmi-c); 2) therapist-delivered brief motivational approach (bmi-t); or 3) a nida drug education booklet. primary outcomes are evaluated at 3-, 6- and 12-months and include marijuana, alcohol, tobacco and other drug use. key moderators of effectiveness will be examined, including behavioral intentions, self-efficacy, stage of change, school involvement, susceptibility to peer pressure, and potential health consequences (e.g., std/hiv risk behaviors). this project will provide the critical first step toward the implementation of tailored marijuana prevention and intervention in primary care clinics.

Eligibility criteria:
inclusion criteria: * adolescents (ages 12-18) presenting to the approved health clinics (except exclusions as noted below) * ability to provide informed assent * access to a parent or guardian for parental consent exclusion criteria: * adolescents who do not understand english * adolescents deemed unable to provide informed consent by research staff (e.g., cognitive issues) * adolescents who come to the clinic because of sexual assault or suicide attempt, or are presenting with high psychological distress requiring intensive attention * prisoners * adolescents who are deaf * adolescents with a sibling or other household member in the study will be excluded from phase ii