Kornimate/medical-research-clean huggingface dataset:
clinical trial on the articular pain of diagnosed patients of arthrosis

Conditions: Osteoarthritis

Summary: randomized, controlled, double-blind clinical trial of three parallel branches to analyze the efficacy of a supplement extracted from the internal membrane of the egg shell on the joint pain of patients diagnosed with osteoarthritis.


Eligibility criteria:
inclusion criteria: * age over 18 years. * subjects diagnosed with osteoarthritis with functional grades i-iii according to the modified criteria of the american college of rheumatology. * subjects must have persistent knee pain associated with osteoarthritis with an initial score of at least 30 mm in the assessment of pain according to the eva scale. * the subjects should not present in their treatment narcotic drugs or steroidal anti-inflammatory or immunosuppressive drugs. exclusion criteria: * serious or terminal illnesses. * subjects who are currently taking glucosamine, chondroitin sulfate, collagen or hyaluronic infiltrates or any supplement indicated for joint health. * subjects with chronic inflammatory diseases that affect the musculoskeletal system (rheumatoid arthritis, gout, pseudo-gout, paget's disease, chronic pain syndrome, etc.). * subjects with a body mass index above 32. * subjects with a known allergy to eggs. * pregnant or lactating women. * inability to understand informed consent.
comparison of tusp versus turp for treatment of benign prostatic hyperplasia in a small prostate volume

Conditions: Benign Prostatic Hyperplasia

Summary: comparison of transurethral split of the prostate versus transurethral resection of the prostate for treatment of benign prostatic hyperplasia in a small prostate volume: a prospective controlled study

transurethral resection of the prostate (turp) was considered as the golden standard to treat benign prostatic hyperplasia (bph) for decades. however, turp was associated with low efficiency to alleviate the lower urinary tract symptoms and a significantly higher risk of bladder neck contracture (bnc) for patients with small-volume bph. we aimed to compare the therapeutic effect of transurethral split of the prostate (tusp) with turp for patients with small-volume bph (\<30 ml). in this study, some selected small-volume bph patients were randomly divided into two groups (tusp and turp group). the patient's baseline characteristics and perioperative outcomes were recorded. the follow-up was made at 6 months, 1 year and 2 years after surgical treatment.

Eligibility criteria:
inclusion criteria: * benign prostatic hyperplasia patients with surgical indication * maximum flow rate \<12ml/s * prostate volume \<30ml * the international prostate symptoms score\>21 * medication of α-adrenergic blockers for at least 3 months exclusion criteria: * acute prostatitis and urethritis * neurogenic bladder * abnormal prostate-specific antigen level * urethral injury history
compared with different method for postcesarean section analgesia

Conditions: Analgesia

Summary: the aim of this study is compare the efficacy of local anesthetic infiltration into all layers of the anterior abdominal wall and peritoneal instillation and intrathecal injection of morphine with local anesthesic to reduce pain in women undergoing elective cesarean section under spinal anesthesia. the primary outcome is to compare the total amount of opioids consumed in the first 24 hours postoperatively. secondary purpose; pain scores at 2,4,6,12,and 24 hours during movement ( moving back and forth in bed ) and rest ( lying motionless in bed )

this prospective randomized double-blind study will be planned on 46 pregnant women aged 18-50 who will undergo cesarean section with pfannenstiel incision under spinal anesthesia with american society of anesthesiologists classification (asa) ii,fullterm singular pregnancy after receiving the approval of the ethics committee of ataturk university medical faculty hospital and written approval of the patients

Eligibility criteria:
inclusion criteria: * pregnant women * 18-50 age * asa ii * fullterm singular pregnancy exclusion criteria: * neuraxial anesthesia is contraindicated, * allergy to the drugs to be used in the study, * refused to participate in the study, * bmi\>35 kg/m2 * asa≥3 * diabetes * preeclampsia, * cardiovascular disease * chronic pain and neuropathic pain, * given opioids in the operation due to intraoperative pain, * switched to general anesthesia, * excessive bleeding during the operation, * uterine atony * drain placed in the area to be infiltrated, * history of drug addiction and psychiatric illness, * understand visual analog pain scale
long term follow-up of the visability™ micro insert system for presbyopic patients

Conditions: Presbyopia

Summary: the objective of this study is to obtain an additional 36 months of safety and effectiveness data from all subjects who were implanted with the visability™ micro insert in the vis-2014 clinical trial.

vis-2014-5yr is a multicenter, observational study to evaluate the long-term safety of the visability™ micro inserts in subjects who were implanted with the visability™ micro insert in the vis-2014 clinical trial. study subjects will be examined at 36, 48, and 60 months post-operatively (based on the anniversary of their first visability™ surgery) with no planned interventions.

Eligibility criteria:
inclusion criteria: * subjects who were implanted with the visability™ micro insert in protocol vis-2014 exclusion criteria: * n/a

Keywords: near vision reading vision reading glasses reading readers presbyopic
the effect of the low fodmap diet in children with autism spectrum disorders

Conditions: Autism Spectrum Disorder

Summary: this study assesses the effect of the low fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (fodmap) diet on gastrointestinal (gi) and behavioral problems in children with autism spectrum disorder (asd). the objectives of this study are: -to determine whether the low fodmap diet causes a decrease in gastrointestinal problems related to asd -to determine whether the low fodmap diet causes a decrease in behavioral problems -to assess the effect of decreased gastrointestinal problems on reduction of behavioral problems

in this study, participants were children with autism spectrum disorder (asd) ages 6-17 years. children with asd were randomized to the low fodmap diet or habitual diet for 2 weeks. at baseline and after a two-week intervention period, the parent/caregiver completed the aberrant behavior checklist-community and pediatric quality of life inventory gastrointestinal module. the parent/caregiver also completed a dietary food record, and stool consistency/frequency record (three days before start to intervention and the last three days of the intervention) of their children.

Eligibility criteria:
inclusion criteria: * 6-17 age range * diagnosed with autism spectrum disorder * parent/caregiver report of constipation and /or abdominal pain. • rome iv criteria was utilized to identify constipation (defined as the presence of two of more of the following symptoms: two or fewer stools per week, at least 1 episode of fecal incontinence per week, history of retentive posturing or excessive volitional stool retention, history of painful or hard bowel movements, presence of a large fecal mass in the rectum, history of large diameter stools that can obstruct the toilet) • rome iv criteria was utilized to identify abdominal pain (defined as the fulfilled at least 4 times per month and include all of the following: episodic or continuous abdominal pain that does not occur solely during physiologic events (eg, eating, menses), insufficient criteria for irritable bowel syndrome, functional dyspepsia, or abdominal migraine, the abdominal pain cannot be fully explained by another medical condition) exclusion criteria: * under 6 and over 17 years old * having a specific restrictive diet to treat allergies or a specific chronic disease - any history of abdominal surgeries * any history of chronic physiological gi disorders such as celiac, inflammatory bowel disease, eosinophilic esophagitis. * any chronic condition that may impact gi function such as thyroid disease, cystic fibrosis, or cardiac abnormalities
translation of quebec back pain disability scale into local languages of pakistan.

Conditions: Low Back Pain

Summary: the aim of the present study is to translate the quebec back pain disability scale into pashto, punjabi, sindhi and balochi languages. along with validation of the translated versions by evaluating their validity and reliability in the people of pakistan, speaking respective languages and suffering from low back pain. no such study has been previously conducted in the pakistan region which translates the scale and follows the proper cross-culture adaptation.

the quebec back pain disability scale is a first-hand measure of functional disability for patients with back pain. it distinguishes itself from other published scales as it has an approach that deals with the concepts of disability and its assessment. its major aim is to be a responsive measure of functional disability in back pain. quebec back pain disability questionnaire has unique strong characteristics that are quite feasibly used and have good identification properties regarding low back pain. there is extensive usage, applicability, and validity of qbpds in research and clinical practice. along with these factors the capability of the qbpds to identify significant fluctuations in patient's condition, makes its use evidently advocated. quebec pain disability scale, originally a french scale has been translated and validated into a few languages before. previous studies have shown that the translation of the scale would end up giving a standard measure to be utilized in clinical practices and research studies while sanctioning clinicians and specialists to share information and to study effects of treatments in low back pain patients. along with helping in appraisals of outcomes amongst various populations. so, to gather the best outcomes of this questionnaire in pakistan region it is imperative to translate it into pashto, punjabi, sindhi and balochi hence the local languages.

Eligibility criteria:
inclusion criteria: * patients both male and female having age group equal or \>18, * should be able to read the questionnaire that is in their native language(punjabi, sindhi, balochi and pashto) and * diagnosed with nonspecific low back pain for more than 3 months. exclusion criteria: * any serious conditions like neurological conditions which would not allow the patient to fill the questionnaire independently, * any infection, tumor, spinal surgery, cognitive impairments, or any other rheumatologic disease would be excluded. * any issues in understanding or expressing the native language (punjabi, pashto, balochi or sindhi) will be excluded.

Keywords: low back pain quebec back pain disability scale tool translation
transperineal laser ablation vs transurethral resection for benign prostatic obstruction: a randomized clinical trial

Conditions: Prostate Hyperplasia; Benign Prostatic Hyperplasia; Benign Prostatic Hypertrophy; Benign Prostatic Hypertrophy With Outflow Obstruction

Summary: the primary objective of the study is to compare trans-perineal laser ablation of prostate versus trans-urethral resection of prostate in the immediate impact on post-operative pain; in terms of relief in benign prostatic obstruction and preservation of the ejaculatory function in the short term (at 1, 3 and 6 months). the secondary objective of the study is the evaluation of the long-term deobstructive effectiveness (12 months).

consecutive patients coming to our institution affected by benign prostatic obstruction (bpo) with indication to surgery and strong need of ejaculatory preservation will be enrolled in the present randomised controlled trial study after counseling. after an informed consent is obtained, uroflowmetry with calculation of the post-voiding residual volume (pvr), a transrectal ultrasonography to estimate prostate volume (pvol), the international prostate symptoms score (ipss) questionnaire with quality of life (qol) assessment, and the evaluation of the ejaculatory sexual function will be performed in all patients. trans-perineal laser ablation of prostate (tpla) will be performed using the echolaser combined system (elesta, italy). during the procedure, two 21g spinal needles are inserted transperineally in the peri-urethral area under ultrasound-guidance. by optical fibers, a maximum energy of 1800 j at a power of 3 watts is delivered. if necessary, the fibers are eventually pulled-back. immediately after the procedure, the patients will be asked to fill in the visual analogue scale (vas) for the assessment of the pain perceived. perioperative data and postoperative data including assessment of ejaculatory function will be analyzed at different time points.

Eligibility criteria:
inclusion criteria: * signed written informed consent * patient able to complete the whole protocol * ipss score ≥ 10 * maximum urinary flow rate \< 15 ml/sec * prostate volume at preop. ultrasonography \< 100 ml * normal urinalysis (all of the above) exclusion criteria: * former prostate surgery * prostate cancer (history) * urethral stricture (history) * marion's disease (history) * bladder stones * median obstructive lobe, as defined by a \> 1 cm of prostate abutting in the bladder lumen at ultrasonography * neurological conditions potentially impacting on the bladder voiding (at least one of the above)

Keywords: tpla turp bph bpo luts
trial to assess vagus nerve stimulation therapy in children with lennox-gastaut syndrome

Conditions: Lennox-Gastaut Syndrome

Summary: the purpose of this study is to evaluate the clinical effectiveness of pins vagus nerve stimulatior in children with lennox-gastaut syndrome.


Eligibility criteria:
inclusion criteria: 1. age 3-14 year 2. lennox - gastaut syndrome diagnostic standard 3. regular drug treatment is invalid 4. antiepileptic drug stability in recent 3 months 5. good health except epilepsy 6. patients or his(her) familyscould understand this method and sign the informed consent 7. patients with good compliance and could complete postoperative follow-up. exclusion criteria: 1. results of mri remind epilepsy caused by intracranial space-occupying lesions 2. had epileptic foci excision surgery or corpus callosum 3. the vagus nerve lesion and damage 4. tumor, cardiopulmonary anomaly, progressive neurological diseases, asthma， mental disease，peptic ulcer，diabetes type 1，bad health etc, and other surgical contraindication 5. participated in other clinical drug test subjects within three months 6. the researchers think that is not suitable for participants'

Keywords: pins vagus nerve stimulator
bevacizumab and carboplatin/paclitaxel and radiation in non-small cell lung cancer

Conditions: Non-Small Cell Lung Cancer

Summary: this study is being done to learn what effects (good and bad) bevacizumab in conjunction with carboplatin/paclitaxel and radiation therapy has on patients with non-small cell lung cancer (nsclc).

* there are three phases of treatment 1)chemoradiation, 2) consolidation and 3)maintenance therapy. * the chemoradiation phase is from week 1 to week 7. the following will occur during this phase: daily chest radiation starting on day 1; pre-medication for paclitaxel; weekly intravenous administration of paclitaxel and carboplatin; intravenous administration of bevacizumab once weekly every three weeks starting on day 1. * during weeks 8-9, patients will undergo a pet/ct scan for restaging. * the consolidation phase is from week 10 to week 16. the following will occur during this phase: pre-medication for paclitaxel; intravenous administration of paclitaxel and carboplatin twice weekly every 3 weeks; intravenous administration of bevacizumab once weekly every 3 weeks. * the maintenance phase is from week 17 to week 52. the following will occur during this phase; intravenous administration of bevacizumab once a week every three weeks for 1 year; pet/ct scan every three months. * the following evaluations will occur during treatment: 1)patients will be evaluated weekly by the study doctor, 2) weight, difficulty or discomfort in swallowing, shortness of breath and over well-being will be recorded, 3) weekly lab test will include cbc, chemistries, and liver function tests. 4) followed through each cycle of chemotherapy and every 6-8 weeks for the duration of the study. * the following evaluations will occur after treatment: 1)every 6-8 weeks assessed for response with a ct or pet/ct scan for one year, 2) toxicity will also be assessed at each follow-up interval.

Eligibility criteria:
inclusion criteria: * histologically confirmed non-small cell lung cancer (nsclc) that have been evaluated and determined not to be candidates for surgical resection as part of their definitive management of stage iii disease. * age 18 years or older * ecog performance status of 0-1 * life expectancy of greater than six months * normal organ and marrow function * women and men of child-bearing potential must agree to use adequate contraception exclusion criteria: * prior chemotherapy or thoracic radiation therapy * squamous histology or any histology in close proximity to a major vessel * active hemoptysis * history of hypercoagulability * known distant metastatic disease * history of allergic reactions attributed to compounds with similar chemical or biological composition to bevacizumab, carboplatin, paclitaxel or other agents used in this study * patients with uncontrolled intercurrent illness * pregnant women * major surgical procedure, open biopsy, or significant traumatic injury with in 28 days prior to day 0 * minor surgical procedure within 7 days to day 0 * hiv-positive patients receiving combination anti-retroviral therapy. * non-skin cancer malignancy in the past 5 years.

Keywords: chemoradiotherapy lung cancer
performance evaluation of a novel non-invasive glucometer, calibrated against validated interstitial glucose references

Conditions: Diabetes Mellitus

Summary: this clinical study has been launched to collect spectral raman data on the investigational medical device (imd) compared with reference methods in terms of interstitial fluid samples and capillary and venous references.

subjects will visit the clinic for a baseline visit and two in-clinic visits. on in-clinic days, subjects will attend the clinic in a fasting state. they will have inserted a dexcom and freestyle libre and a microdialysis catheter. at time = 0, subjects will be administered a glucose rich drink and every 6. minut measurements will be performed. these include a measurement on the imd, microdialysate, freestyle libre and dexcom readings. every 18. minut a venous blood sample will be included and every 36. minut a capillary blood sample will be collected. this continues until time = 180 minutes.

Eligibility criteria:
inclusion criteria: * male and female subjects 18-70 years old * patients diagnosed with type 1 or type 2 diabetes (t1d or t2d) (insulin requiring t2d patients) * diabetes management strategy: lifestyle regimen + insulin ± oral hypoglycemic agents * skin phototype 1-4 exclusion criteria: * for female participants: pregnancy or subject is attempting to conceive or not willing and able to practice birth control during the study duration * \> 10 cigarettes pr. day * participants not able to understand and read swedish * in investigator's opinion, participant is not able to follow instructions as specified in the protocol * participants not able to hold hand/arm steadily (including tremors and parkinson's disease) * diagnosed with reduced circulation * extensive skin changes, tattoos or diseases on probe application site * rejection by screening optical measurements * known allergy to medical grade alcohol * known allergy to adhesives * systemic or topical administration of glucocorticoids for the past 7 days * participants undergoing dialysis treatment * anti-coagulation or anti-platelet therapy * use of beta-blockers * medical conditions causing bleeding tendency * medical history or any condition that may, in the opinion of the investigator, compromise the subject's ability to participate * concomitant medical condition which could present a risk to the safety or welfare of the subject or study staff. such conditions include but are not limited to hiv and hepatitis b or c. * participants currently enrolled in another study

Keywords: non-invasive glucose monitoring raman spectroscopy
lung recruitment in laparoscpic surgery

Conditions: Atelectasis, Postoperative

Summary: the goal of this clinical trial study is to assess the effectiveness of different methods of lung recruitment maneuver on the incidence of atelectasis in adults undergoing laparoscopic cholecystectomy surgery using lung ultrasound participants will be divided into three groups as: control group, sustained inflation group (si) and stepwise positive end expiratory pressure increasing group(third group). each contains 31 patients. control group = keep parameters all through the procedure without any changing group(si) = after abdominal deflation, we will apply sustained inflation by adjusting adjustible pressure limiting valve 40 centimetres water on spontaneous mode, holding the bag for 30 second. third group = after abdominal deflation, we will apply stepwise positive pressure increasing by 2 centimetres water every 5 breathing cycles till reaching 12 centimetres water and keeping it till extubation, with a maximum airway pressure not exceeding 40 centimetres water.

the effectiveness of different methods of lung recruitment maneuver on the incidence of atelectasis in adults undergoing laparoscopic cholecystectomy surgery using lung ultrasound participants will be divided into three groups as: control group, sustained inflation group (si) and stepwise positive pressure increasing group. each contains 31 patients. control group = keep parameters all through the procedure without any changing group(si) = after abdominal deflation, the investigators will apply sustained inflation by adjusting adjustible pressure valve 40 centimetres water spontaneous mode, holding the bag for 30 second. third group = after abdominal deflation, the investigators will apply stepwise positive pressure increasing by 2 centimeters water 5 breathing cycles till reaching 12 centimetres water and keeping it till extubation, with a maximum airway pressure not exceeding 40 centimetreswater. during the entire procedure the transducer head will be placed over one point of the chest selected by the operator where the area of atelectasis was detected the probe will be placed in the atelectasis area.

Eligibility criteria:
inclusion criteria: * patients with healthy lungs * age between 18 and 65 years old * body mass index (bmi) \<30 kg / m2 * physical status i-ii of the american society of anesthesiologists (asa) * elective laparoscopic cholecystectomy. exclusion criteria: * patient refusal * patients with preoperative ultrasound evidence of pulmonary atelectasis. * patients who will have conversion from laparoscopic to open surgery. * patients experiencing critical postoperative complications such as severe subcutaneous emphysema and pneumothorax. * patients with pulmonary, cardiac, and neuromuscular diseases and a corresponding surgical history and respiratory tract infections.

Keywords: laparoscopic, atelectasis, recruitment maneuver,