Kornimate/medical-research-clean huggingface dataset:
advanced medical therapy versus advanced medical therapy plus bariatric surgery for the resolution of type 2 diabetes

Conditions: Diabetes Mellitus, Type 2; Obesity

Summary: the aim of the study is to compare the relative clinical outcomes between advanced medical therapy alone or advanced medical therapy combined with bariatric surgery \[either roux-en-y gastric bypass (rygbp) or laparoscopic sleeve gastrectomy\] in patients with type 2 diabetes and a body mass index (bmi) between 27 and 43 kg/m2. the study will examine the short and long term effects of each intervention on biochemical resolution of diabetes, diabetic complications, and end-organ damage.


Eligibility criteria:
inclusion criteria: * type 2 diabetes mellitus with hba1c \> 7.0% * body mass index \> 27 and \< 43 kg/m2 * candidate for general anesthesia exclusion criteria: * prior bariatric surgery of any kind * cardiovascular conditions including significant coronary artery disease, peripheral vascular disease, uncompensated congestive heart failure, history of stroke, or uncontrolled hypertension * kidney disease or chronic renal insufficiency with a creatinine level \> 1.8 mg/dl * known history of chronic liver disease (except for nafld/nash) * gastrointestinal disorders, malabsorptive disorders, or inflammatory bowel disease * psychiatric disorders including dementia, active psychosis, severe depression requiring \> 2 medications, history of suicide attempts, alcohol or drug abuse within the previous 12 months * severe pulmonary disease defined as fev1 \< 50% of predicted value * pregnancy

Keywords: diabetes mellitus, type 2 obesity
long-term neurodevelopmental disorders of prematurely born children and parental experience

Conditions: Neurodevelopmental Abnormality

Summary: thanks to the evolution in knowledge and technical advances in premature newborn intensive care, the survival of very premature infants is now possible. however, prognosis remain sometimes uncertain. in 2011, the epipage 2 study showed a significant improvement as compared with the 1997 epipage1 study with a decrease in mortality and an increase of the survival rate without severe morbidity of 14% for preterm babies born between 25 and 29 weeks and 6% for babies born between 30 and 31 weeks. however, surviving babies without initial major deficiencies, may later show problems in terms of growth, sensory - motor and/or neuro-psychologic development. this untoward evolution lead to social and family interaction disorders and school difficulties. in this context, a perinatal care network was created for each region in france, making it possible to take care of these vulnerable children early on and all along their development. a retrospective study will evaluate 97 pre-term babies born before 33 weeks in 2012 and who are taken care of at nancy as part of the lorraine regional network program "rafael" until they are 7 years old. the objective is to evaluate objectively the neurocognitive and school abilities of these children at the age of 7. at 8 years of age, a secondary measure of outcome will be the impact of the eventual neurocognitive consequences on the quality of their family life, on the behavior of the child and the parents' feelings. this way more options to improve the way they are taken care of will be available.


Eligibility criteria:
inclusion criteria: * all children prematurely born between 24 and 33 completed week during 2012 * and involved in the lorraine perinatal follow-up program at 7 years old exclusion criteria: * children not able to respond to the eda evaluation
clinical study on implicit learning, comorbidity and stress vulnerability in chronic functional pain

Conditions: Fibromyalgia; Irritable Bowel Syndrome

Summary: the project investigates on the role of pain avoidance, comorbidity and stress response for the development of chronic somatic and visceral pain. we, the researchers at university hospital mannheim, assume that implicit operant learning of pain sensitization is a central mechanism of the process of pain becoming chronic, which is augmented by fear and by avoidance behaviour. somatic and psychological comorbidity as well as stress factors are further promoting factors in chronic pain development.

study 1: implicit operant learning of sensitization and habituation in an experimental heat pain model will be investigated and compared in healthy controls, chronic pain patients with fibromyalgia, with and w/o visceral pain. study 2: functional imaging of implicit operant learning of sensitization and habituation in an experimental heat pain model (same subgroups as in study 1).

Eligibility criteria:
inclusion criteria: * fibromyalgia according to american college of rheumatology (acr) criteria * visceral hypersensitivity according to rome criteria * chronic pain according to international association for the study of pain (iasp) criteria exclusion criteria: * abnormal quantitative sensory testing * psychiatric or neurological anamnesis, except fear and depression * acute major depression * substance abuse

Keywords: experimental study chronic pain operant learning comorbidity stress fibromyalgia w visceral hypersensitivity fibromyalgia w/o visceral hypersensitivity
single arm clinical trial of small molecule natural flavonoid compounds for intervention in neurodegenerative diseases

Conditions: Neurodegenerative Diseases

Summary: 1. explore the effects of natural plant flavonoids on the positive intervention mechanism of neurotransmitter transmission physiological indicators changes (eeg) in the brain of the study subjects; 2. investigate the effects of natural plant flavonoids in positively intervening clinical symptoms of the study subjects.


Eligibility criteria:
inclusion criteria: 1. age: 25-70 years 2. patients complaining of sleep disorders, mood disorders (unstable mood, irritability, depression and anxiety) and cognitive decline (people with memory, decreased reaction time, bpsd symptoms) within one month 3. montreal cognitive assessment scale (moca) score ≤26; if moca score is not satisfied, then pittsburgh sleep quality index (psqi) score \>10 and hamilton anxiety scale (hama) score \>14 or hamilton depression scale (hamd) score ≥8 are required 4. patients who can understand and communicate in language, and complete aphasia patients are not included; 5. patients who agree to participate in this clinical observation and sign the informed consent form. exclusion criteria: 1. patients with severe organ diseases such as heart, kidney, and liver failure, chronic lung diseases such as copd, and severe diabetes; 2. patients with severe uncontrolled hypertension; 3. patients who have taken antipsychotic drugs within the past two weeks; 4. patients with the core features of lewy body dementia or significant behavioral variant frontotemporal dementia; 5. patients with various malignant tumors; 6. patients with progressive stroke, transient ischemic attack, cerebral hemorrhage after cerebral infarction, and cerebral arteritis; 7. patients with brain tumors, brain trauma, cerebral parasitic diseases, and other conditions; 8. pregnant or lactating women; 9. patients allergic to the known ingredients used in this trial; 10. patients with active ulcers or bleeding tendencies; 11. patients with neurodegenerative diseases such as huntington's disease, amyotrophic lateral sclerosis, and pick's disease; 12. other patients who are deemed unsuitable to participate in this trial by the investigators.
interest of pre-operative use of 3d printing for endovascular treatment of unruptured intracranial aneurysms with intrasaccular flow disruptor

Conditions: Intracranial Aneurysm

Summary: this is a preliminary randomised controlled trial comparing the use of pre-operative 3d models to select an intrasaccular flow disruptor for endovascular aneurysm cure.

patients will be randomised 3:1 either in the intervention or control group. intervention consists of using the pre-operative digital subtraction angiography (dsa) to create a 3d plastic model. this model is used to test different sizes of device. at the end of this pre-operative test a single device is recommended for the real procedure. the control group will use the current method for size selection (measurement of mean width and minimum height) on dsa.

Eligibility criteria:
inclusion criteria: * intracranial aneurysm, suitable for a treatment by woven endobridge (web) device after multidisciplinary team decision * consent form signed * the patient benefits from health insurance exclusion criteria: * legal incapacity * women at risk of pregnancy
ed90 of norepinephrine and phenylephrine boluses under intensive treatment

Conditions: Adverse Effect

Summary: the objective of this study is to investigate the ed90 of norepinephrine and phenylephrine boluses for treating postspinal anesthesia hypotension under intensive treatment during cesarean section

post-spinal anesthesia hypotension is a frequent complication during spinal anesthesia for cesarean section. the incidence of post-spinal anesthesia hypotension is as high as 62.1-89.7% if prophylactic measures are not taken. the 2016 asa guidelines for obstetric anesthesia suggest avoiding hypotension following spinal anesthesia in women and emphasize the use of vasopressors, specifically alpha-receptor agonists, as the preferred strategy to prevent and manage post-spinal anesthesia hypotension. the 2018 international consensus in the united kingdom and northern ireland recommends maintaining maternal systolic blood pressure above 90% of the baseline value following lumbar anesthesia, while avoiding dropping below 80% of the baseline value. currently, the threshold for maintaining blood pressure above 80% of the baseline value is widely adopted as a standard; however, limited evidence supports the advantage of sustaining maternal blood pressure above 90% of the baseline value. the objective of this study is to investigate the ed90 of norepinephrine and phenylephrine boluses for treating postspinal anesthesia hypotension under intensive treatment during cesarean section

Eligibility criteria:
inclusion criteria: * 18-45 years * primipara or multipara * singleton pregnancy ≥37 weeks * american society of anesthesiologists physical status classification i to ii * scheduled for cesarean section under spinal anesthesia exclusion criteria: * body height \< 150 cm * body weight \> 100 kg or body mass index (bmi) ≥ 40 kg/m2 * eclampsia or chronic hypertension or baseline blood pressure ≥180 mmhg * hemoglobin \< 7g/dl * fetal distress, or known fetal developmental anomaly
get with the guidelines-heart failure registry

Conditions: Heart Failure

Summary: get with the guidelines-heart failure is designed to improve the quality of care in patients hospitalized with heart failure. the program aims to help ensure that eligible patients are initiated on guideline recommended therapies and receive appropriate counseling prior to hospital discharge.

get with the guidelines-heart failure was initiated in 2005 with over 500 u.s. hospitals participating is designed to improve the quality of care in patients hospitalized with heart failure. the program aims to help ensure that eligible patients are initiated on guideline recommended therapies and receive appropriate counseling prior to hospital discharge. peer-reviewed research(with over 35 manuscripts) has demonstrated that through participating in get with the guidelines-heart failure, hospitals will provide equitable care (regardless of race, ethnicity, age, or gender), the importance of scheduled physician follow-up after heart failure hospital discharge, the value in device-support as necessary for the acute heart failure patient, and many other significant findings. achievement measures tracked through get with the guidelines-heart failure: * angiotensin converting enzyme inhibitor (acei) and angiotensin receptor blocker (arb) at discharge * evidence-based specific beta blockers * measure left ventricular function * post-discharge appointment for heart failure patients quality measures tracked through get with the guidelines-heart failure: * mineralocorticoid receptor antagonist at discharge * aldosterone antagonist at discharge * anticoagulation for atrial fibrillation * hydralazine nitrate at discharge * dvt prophylaxis * crt-d or crt-p placed or prescribed at discharge * icd counseling, or icd placed or prescribed at discharge * influenza vaccination during flu season * pneumococcal vaccination * follow-up visit within 7 days or less * lab monitoring follow-up * sglt-2 inhibitor at discharge * defect-free care for quadruple therapy medication for patients with heart failure with reduced ejection fraction * direct-acting oral anticoagulant at discharge for non-valvular atrial fibrillation or atrial flutter patients additional measures collected by get with the guidelines-heart failure can be viewed at: http://www.heart.org/idc/groups/heart-public/@wcm/@private/@hcm/@gwtg/documents/downloadable/ucm_310967.pdf

Eligibility criteria:
inclusion criteria: * patients hospitalized with congestive heart failure. exclusion criteria: * patients who do not have congestive heart failure, * patients under age of 18, * patients not admitted as inpatients.
efficacy of coconut oil with peppermint essential for oral hygiene routine

Conditions: Fluoride Adverse Reaction

Summary: this randomized clinical trial will be conducted to investigate the efficacy of an innovative tooth cleaning agent extra virgin coconut oil with peppermint essential oil by oil pulling and toothbrushing with oil on reducing salivary streptococcus mutans levels, tooth decay and plaque buildup versus on the counter toothpaste in high caries risk patients.

everyday use of dental health care products has increased. therefore, there is a legitimately increased interest of healthcare clinicians and consumers in substances added to the toothpaste with the intention to improve their performance and potential benefits and risks that may arise from it. as there are harmful products in the toothpaste for instance: (fluoride, sodium lauryl sulphate (sls), sodium saccharin and triclosan which is assumed that it because local reaction includes oral mucosa irritation and desquamation (stomatitis, glossitis, gingivitis, buccal mucositis), while systemic ones are allergic and acute or chronic toxic reactions. rational harmful products in the toothpaste for instance: (fluoride, sodium lauryl sulphate (sls), sodium saccharin and triclosan which is assumed that it because local reaction includes oral mucosa irritation and desquamation (stomatitis, glossitis, gingivitis, buccal mucositis), while systemic ones are allergic and acute or chronic toxic reactions.

Eligibility criteria:
inclusion criteria: * patients will be recruited in this study, will be medically free. * age range 20-50 years * patients with high caries risk assessment (0- 30% high caries risk) according to cariogram - a multifactorial risk assessment model for dental caries. * non-smoking patients * not under antibiotic therapy either at the time of the study or up to the last month before the start of the study. * male or female patients * patients have brushing habits * no fixed orthodontic treatment * no active or untreated caries * patients on non-cariogenic diet exclusion criteria: * patients with a compromised medical history. * patients with low caries risk assessment according to cariogram - a multifactorial risk assessment model for dental caries. * patients with severe or active periodontal disease. * patients with a history of allergy to any of the drugs or chemicals will be used in the study. * patients on any antibiotics during the past month. * smoking patient * patients with very low saliva secretion xerostomia less than 0.5ml stimulated saliva /min score 3 according to cariogram * pregnant female patient * no brushing habits * fixed orthodontic treatment * active or untreated caries * patients on cariogenic diet
a study to evaluate chang gung pneumothorax detection software

Conditions: Pneumothorax

Summary: the chang gung pneumothorax detection software is a medical software that can automatically detect whether there is a pneumothorax in chest x-ray. the purpose of this study is to verify whether the chang gung pneumothorax detection software can correctly identify patients with pneumothorax in chest x-ray. the results of the software analysis will be used for the performance of the software on the primary and secondary outcomes.

this clinical trial is a retrospective study. dicom images of de-identified chest x-ray were collected from 6 hospitals of chang gung memorial hospital from january 1, 2006 to december 31, 2020. the test set of 5,347 items was established, and total of 344 cases will be sampled by simple random stratification, including 172 cases with pneumothorax and 172 cases without pneumothorax. the image must be in dicom format. follow-up by three specialist physicians to interpret the presence or absence of pneumothorax, the result will be the standard of this test (reference). after confirming the correct standard of each chest x-ray, the chest x-ray will be put into chang gung pneumothorax detection software, and analyzed by the primary and secondary outcomes.

Eligibility criteria:
inclusion criteria: * the case were over 20 years old and under 100 years old. * dicom format. * brand model of canon. * dicom resolution length range (700-3400 pixels), width range (490-3600 pixels). * poster-anterior view(pa-view) of chest x-ray exclusion criteria: * the chest x-ray contains items that affect interpretation, such as chest tubes, endotracheal tubes, and heart rhythm regulators, but does not include patches and circuits used in electrocardiograms. * the chest x-ray that are difficult to interpret due to poor image quality.

Keywords: artificial intelligence
human versus analogue insulin in patients after pancreatectomy.

Conditions: Pancreatogenous Diabetes

Summary: pancreatectomy is a common treatment modality for both benign and malignant pathologies. one of the most common complications after pancreatectomy is pancreatogenous diabetes mellitus. yet, insulin remains treatment of choice in patients after pancreatectomy, however there is little evidence on the choice of insulin preparation in patients with diabetes after pancreatectomy. in particular, it is unclear whether human or analogue insulin should be preferred in this group of patients.the aim of the study was to compare human vs analog insulin therapy in patients with diabetes prior to or diabetes developing after pancreatectomy performed due to pancreatic tumor. the study was designed as an open, prospective, randomized, intervention study.all patients provided written comprehensive informed consent. after surgery all patients who underwent total pancreatectomy were treated with insulin, while the patients who had partial pancreatectomy performed were treated with basal insulin when fasting plasma glucose exceeded 140 mg/dl and with prandial insulin when 2-hour postprandial plasma glucose exceeded 180 mg/dl.the patients who required insulin treatment after surgery were randomized with the use of random numbers generator (www.randomizer.org) into two groups: group 1 - treated with insulin analogues (lispro, glargine), group 2 - treated with human insulin preparations (regular and nph insulin).the clinical and metabolic assessment was carried out 3 and 6 months after surgery. the study was approved by local ethics committee.


Eligibility criteria:
inclusion criteria: •patients with pancreatic tumor confirmed in imaging studies and qualified for surgical treatment exclusion criteria: •active psychiatric disease not amenable to treatment and hindering cooperation

Keywords: human insulin insulin analogues
letting children listen to music during computed tomography

Conditions: Fear; Computed Tomography

Summary: this study examines the effect of music during computed tomography in children. this study, conducted on a total of 60 children, was divided into two groups: the music group and the control group. according to the research results; showed that music reduces fear and anxiety levels in children and stabilizes vital signs (pulse and respiratory rate) during a tomography scan.

aim: this research was conducted to determine the effect of music played during computerized tomography (ct) imaging in children on fear, anxiety and vital signs. method: this randomized, double-blind controlled trial was conducted with consolidated standards of reporting studies (consort) guidelines. the sample includes children aged 5-10 years who had ct scans in the emergency department of a public hospital in eastern turkey between april 18 and may 20, 2023 and met the inclusion criteria for the study. the research was completed with a total of 60 children, divided evenly into one of two groups. the nursing intervention of the research is to listen to music. data were collected through face-to-face interviews using the child and family information form, the child fear scale, the state anxiety scale for children, and the vital signs monitoring form (pulse, blood pressure, and oxygen saturation). ethical principles were followed in the research.

Eligibility criteria:
inclusion criteria: * being between the ages of 5-10 * hospitalization is for diagnostic or treatment purposes * the child and the parent speak and understand turkish comfortably. exclusion criteria: * having previous tomography shooting experience * having chronic diseases * visual, auditory, speech and mental disorders * there is a history of sedative, analgesic or narcotic substance use within 24 hours before application.

Keywords: child music anxiety fear
engagement of patients with advanced cancer

Conditions: End of Life; Advanced Cancer; Lung Neoplasm; Gastric Cancer; Colon Cancer; Glioblastoma Multiforme; Head and Neck Neoplasms; Rectum Cancer; Melanoma; Kidney Cancer; Prostate Cancer; Testicular Neoplasms; Liver Cancer; Cancer of Unknown Origin

Summary: the engagement of patients with advanced cancer is an intervention that utilizes well-trained lay health coaches to engage patients and their families in goals of care and shared decision-making after a diagnosis of advanced cancer. although lay health workers have never been tested in this role, we hypothesize that lay health workers can feasibly improve goals of care documentation and help to reduce unwanted healthcare utilization at the end of life for veterans diagnosed with new advanced stages of cancer and those diagnosed with recurrent disease.

vapahcs proposes to implement and evaluate several critical elements to be in alignment with the vha's strategic goal and priority areas for fy2013. the engagement of patients with advanced cancer project is an innovative program that will strengthen provider-patient relationship and facilitate whole person care about matters important to veterans with cancer and important to support network and family. the project is intended to help establish goals of care plan with appropriate documentation, develop, deploy, and evaluate a model of care for persons with cancer that is intended to improve clinical outcomes and experience of care for individuals with advanced cancer who have advanced cancer (stages iii, iv or recurrent disease). the intervention provides patients with lay health coaches who assist patients and their families in discussing goals of care and engage in shared-decision making. the goal of the project is to demonstrate that there is improved patient experiences, outcomes, and that the program helps to reduce utilization of health care resources at the end of life.

Eligibility criteria:
inclusion criteria: * newly diagnosed stage iii or iv cancer * recurrent disease (any stage) * ability to consent to study exclusion criteria: * patients who are unable to consent to study procedures