Kornimate/medical-research-clean huggingface dataset:
strategy based technique to enhance memory (stem) for improving new learning and memory (nlm) in moderate to severe tbi

Conditions: Traumatic Brain Injury; Cognitive Impairment

Summary: the purpose of this research study is to investigate the effectiveness of a memory enhancement technique in persons with a traumatic brian injury (tbi). the study is designed to research how well this technique can help people with tbi improve their memory and their ability to function better in everyday life

impairments in higher level cognitive processing, such as new learning and memory, are common in traumatic brain injury (tbi)and negatively impact multiple aspects of everyday life, including occupational and social functioning. despite this, few studies have attempted to remediate these cognitive deficits in order to improve everyday functioning. while not applied in traditional rehabilitation protocols as of yet, many techniques from cognitive psychology significantly improve learning and memory in healthy persons. these techniques include the generation effect (ge), the spacing effect (se), and the testing effect (te). these techniques have recently been incorporated into an 8-session treatment protocol, stylistic memory enhancement (sme), designed to teach participants about each of the techniques, train them on how to apply the techniques in daily life and practice their application to daily life memory demanding situations. the protocol includes teaching participants how to restructure a memory demanding situation in order to make optimal use of self-generation, spaced learning and self-testing.

Eligibility criteria:
inclusion criteria: in order to participate in this study i must meet the following requirements: * i am between the ages of 18-65. * i have had a traumatic brain injury (tbi) at least 1 year ago. * i can read and speak english fluently. * i have difficulties with learning and memory skills. exclusion criteria: * i have had a prior stroke or neurological injury/disease other than tbi. * i have a history of significant psychiatric illness (for example, bipolar disorder, schizophrenia, or psychosis) or a current diagnosis of major depressive disorder, schizophrenia, bipolar disorder i or ii. * i have a significant alcohol or drug abuse history (inpatient treatment). * i am taking certain medications that might exclude me from the research. the study team will review my medications with me.

Keywords: traumatic brain injury cognitive impairment intervention
local ige in subjects with allergic or non-allergic rhinitis

Conditions: Perennial Rhinitis

Summary: the purpose of the study is to investigate the incidence of non-allergic rhinitis on a not selected group of young students (n=100-300). students will be selected by public posting. in all students an allergy skin test will be performed. then the local ige of 24 subjects with non-allergic rhinitis will be compared to the local ige of 24 subjects with allergic rhinitis and positive prick test to house dust mite. in addition 20 controlls will be investigated. based on these investigations, the importance of local ige and the ige spectrum in conjunction with rhinitis should be further clarified.

20% of germans suffer from seasonal or all-season rhinitis. despite typical allergic symptoms, in a part of the affected patients (about 10-20%) an allergy cannot be found on skin prick test or blood. therefore, the planned trial will investigate the incidence of allergic and non-allergic rhinitis in a non selected group of young students (n=100-300). the hypothesis postulates that in test subjects with non-allergic rhinitis the allergy can only be proven locally in nasal secretion. from the initial large cohort of patients, 24 subjects with house dust mite allergy and allergic rhinitis and 24 patients with non-allergic rhinitis will be selected and investigated in more detail at a second visit. at the second visit, blood and nasal secretion (measurement of local ige) will be taken from all pre-selected 48 patients. at visit 2 a nasal provocation test with house dust mite allergen will be performed in all patients to compare nasal symptoms with the results of local ige between patient groups. in addition the same investigations will be performed in a group of 20 healthy non-allergic subjects.

Eligibility criteria:
inclusion criteria: * informed consent * seasonal or all-season symptoms of an allergic or non-allergic rhinitis * healthy non-allergic subjects exclusion criteria: * patients: age \ 45 * other severe diseases (e.g. cystic fibrosis, diseases with immunosuppression, malignant diseases) * previously occurred allergic shock * pregnancy and lactation * participation in another clinical trial within the last 30 days * inability to measure the length and the consequences of the study * frequent use of medication which could not be discontinued in the defined time before enrollment: nasal vasoconstrictors 1 day; antihistamines 3 days; nasal steroids 7 days; oral cortison 4 weeks; leukotriene antagonists and cromolyn 2 days before npt

Keywords: local ige non-allergic rhinitis allergic rhinitis to house dust mite
determination of heart rate in infants needing resuscitation at birth

Conditions: Perinatal Asphyxia

Summary: algorithms for neonatal resuscitation adapted to low resource settings include hr evaluation by auscultation or umbilical cord palpation at about one minute of life. previous studies conducted in high resource settings showed that auscultation of the precordium is more accurate than umbilical palpation to assess hr of healthy infants at birth.the last versions of the american heart association and the european resuscitation council guidelines on neonatal resuscitation suggest that "during resuscitation of term and preterm newborns, the use of 3-lead ecg for the rapid and accurate measurement of the newborn's heart rate may be reasonable". however, this remains a weak recommendation with a very-low-quality evidence. in low resource countries, a stethoscope is rarely available and palpation of the umbilical pulse is the method used for detecting hr. although this is preferable to other palpation sites (i.e. femo-ral and brachial artery), there is a high likelihood of underestimating hr with palpation of the umbilical pulse in healthy infants. the accuracy of assessing hr by auscultation and umbilical palpation in newborn infants requir-ing resuscitation remains unknown. to the investigator's knowledge, there are not previous studies that have compared the accuracy of hr estima-tion by auscultation vs. umbilical palpation in newborn infants needing resuscitation this study was designed to compare two different methods (auscultation and umbilical cord pal-pation) of hr estimation in newborn infants needing resuscitation, in order to determine which method is most suitable for use in clinical practice.


Eligibility criteria:
inclusion criteria: 1. inborn infants (and) 2. need for resuscitation (and) 3. parental consent; a written informed consent will be obtained by a member of the neonatal staff involved in the study from a parent or guardian at maternal admission to the obstetrical ward or prior to delivery. exclusion criteria: 1. major congenital malformations; 2. parental refusal to participate to the study.
fluid administration in ketoacidosis (drink)

Conditions: Diabetic Keto-acidosis

Summary: management of severe diabetic ketoacidosis is based on insulin therapy, correction of metabolic disorders and fluid resuscitation. current recommendations recommend the first-line use of isotonic saline, whose composition is unbalanced, rich in chloride and sodium compared with plasma. administration of large volumes of isotonic saline is associated with a risk of hyperchloremic metabolic acidosis and acute renal failure. balanced solutions (e.g. ringer lactate) are solutions with a more balanced electrolyte composition close to that of plasma. they could therefore enable diabetic ketoacidosis to be resolved more quickly than isotonic saline, due to a lower risk of hyperchloremic acidosis. preliminary data suggest a potential benefit of balanced solutions for fluid resuscitation of patients with severe diabetic ketoacidosis in terms of resolution of diabetic ketoacidosis, but no randomized controlled double-blind study to date has compared balanced solution vs. isotonic saline in this context.


Eligibility criteria:
inclusion criteria: * admission to emergency department or direct admission to icu * diagnosis of severe diabetic ketoacidosis requiring all the following criteria: * blood or capillary glucose \> 11 mmol/l * ketonemia or ketonuria \> 0 * venous or arterial ph \< 7.30 or venous or arterial bicarbonate \< 15 mmol/l * volume of fluid administered before inclusion \<1l exclusion criteria: * patients \<18 years * pregnant women * patients under protection * patients with a decision to withdraw life-sustaining therapy * contraindication to isotonic saline or ringer lactate * non-affiliation to social security
safety of transplantation of crispr ccr5 modified cd34+ cells in hiv-infected subjects with hematological malignances

Conditions: HIV-1-infection

Summary: the investigators performed this study to evaluate the safety and feasibility of transplantation with crispr/cas9 ccr5 gene modified cd34+ hematopoietic stem/progenitor cells for patients that develop aids and hematological malignances. patients will be treated with antiviral therapy (art) to achieve undetectable hiv-1 virus in peripheral blood before conditioning. cd34+ cells from donors will be infused into the patients after treatment with crispr/cas9 to ablate ccr5 gene.

the primary objective of this study is to determine the safety of the infusion of cd34+ cells which are treated with crispr/cas9 to disrupt the ccr5 gene. the secondary objective is to evaluate the resistance to hiv-1(r5) in infected patients after infusion of modified cd34+ cells with or without an antiretroviral therapy interruption (ati). after the transplantation, the reconstitution time and frequency of multi-lineage hematopoietic cell will be analyzed against previously reported hsct in hiv-1 patients. after the detection of high cd4+ t cells reconstitution (over 600 cells/μl) and ccr5 negative cells (over 1%) in peripheral blood, subjects will undergo an ati. hiv-1 rna level and cd4+ cell counts will be monitored biweekly for at least one month.

Eligibility criteria:
inclusion criteria: 1. age between 18 to 60, male of female; 2. hematological neoplasms; 3. hiv-1 r5 tropic virus with no cxcr4-tropic or r5/x4 dual-tropic hiv; 4. on art with undetectable hiv-1 level (\<40gc/ml, hiv-1 rna); 5. availability of a consenting hla-matched donor; 6. no cardiomyopathy or congestive heart failure; 7. cd4+ t-cell counts ≥200 cells/µl and ≤750 cells/µl; 8. absence of psychosocial conditions and be willing to comply with study-mandated evaluations for 2 years; 9. life expectancy of at least 1 year. exclusion criteria: 1. acute or chronic hepatitis b or hepatitis c infection; 2. any cancer or malignancy other than hematological neoplasms; 3. subject with cmv retinitis or other active cmv infection related diseases; 4. subject with organ dysfunction; 5. non-pregnant and non-nursing; 6. drug or alcohol abuse or dependence; 7. currently enrolled in another clinical trial or underwent cell therapy; 8. donor incapable for hspc mobilization; 9. in the opinion of the site investigator, would interfere with adherence to study requirements.
dance therapy as an alternative for cardiac rehabilitation in women population

Conditions: Cardiac Risk Factors; Cardiovascular Diseases

Summary: this research project aims to investigate the acute effects of a dance-based cardiac rehabilitation session in the cardiovascular system and autonomic modulation of women with cardiac risk factors. also, as a secondary outcome, to compare the cardiovascular and autonomic responses of the dance-based session to a conventional exercise-based session.


Eligibility criteria:
inclusion criteria: * hemodynamically stable * previously attending exercise-based cardiac rehabilitation and dance classes for at least 3 months * do not present orthopedics or neurologic impairments that could preclude the execution of dance movements * to be previously diagnosed with at least one of the following cardiac risk factors: 1. age ≥ 55 years 2. family history: known myocardial infarction, coronary revascularization, or sudden death in the first-degree relatives before 55 years in male or 65 years in female relatives 3. hypertension: values of systolic blood pressure (sbp) equal to or higher than 140 mmhg and/or values of diastolic blood pressure (dbp) equal to or higher than 90 mmhg, or daily use of antihypertensive drugs 4. dyslipidemia: values of low-density lipoprotein (ldl) ≥ 130 mg.dl-1, or values of high-density lipoprotein (hdl) \< 40 mg.dl-1, or daily use of lipid-lowering drugs 5. obesity: body mass index ≥ 30 kg.m-2 6. cigarette smoking: former smokers for more than six months 7. diabetes mellitus: fasting blood glucose level ≥ 100 mg.dl-1 8. physically inactivity: the volunteer will be considered physically inactivity when classified as "sedentary" or "irregularly active a or b" by the international physical activity questionnaire (ipaq) 9. stress: the presence of stress will be evaluated by the lipp's stress symptoms inventory (lssi), and the classifications "alert", "resistance", and "exhaustion" will be considered exclusion criteria: * volunteers who present errors superior to 5% in the rr intervals time series * volunteers who do not attend all study phases

Keywords: cardiac rehabilitation dance therapy cardiac risk factors autonomic nervous system heart rate
comparison of silodosin and tamsulosin for medical expulsive therapy in patients with ureteral stones

Conditions: Tamsulosin; Silodosin; Medical Expulsive Therapy

Summary: this study compares the effectiveness and side effect profiles of tamsulosin and silodosin in medical expulsive therapy (met) for ureteric stones. conducted as a randomized control trial at sir ganga ram hospital, lahore, 180 patients were analyzed-89 on tamsulosin and 93 on silodosin. results showed that silodosin had a higher stone expulsion rate, especially within 14 days, and fewer side effects compared to tamsulosin. common side effects included orthostatic hypotension, abnormal ejaculation, and headaches, with silodosin showing a better overall safety profile.

this study was designed as a prospective, randomized, open-label, controlled trial conducted at the urology department of sir ganga ram hospital, lahore, over a period of 12 months. ethical approval was obtained from the institutional review board, and written informed consent was secured from all participants. participants included adults aged 18 to 60 years with a single, unilateral ureteric stone measuring 5 to 10 mm, confirmed by non-contrast ct scan. patients with a history of ureteral surgery, congenital anomalies, severe renal impairment (serum creatinine above 1.5 mg/dl), pregnancy, lactation, urinary tract infection, or those using calcium channel blockers or other alpha-blockers were excluded. a total of 180 eligible patients were randomized into two groups: 89 patients received tamsulosin 0.4 mg daily, while 93 patients received silodosin 8 mg daily. both groups received standard analgesia with diclofenac sodium 50 mg as needed and were advised to maintain adequate hydration. treatment continued until stone expulsion or for a maximum of 28 days. patients were monitored weekly through clinical evaluation and imaging (ultrasound or x-ray), and adverse events such as dizziness, ejaculatory dysfunction, and headaches were recorded using standardized questionnaires. data analysis was performed using spss version 25.0. continuous variables were compared using student's t-test, while categorical variables were assessed with chi-square or fisher's exact test. a p-value of less than 0.05 was considered statistically significant.

Eligibility criteria:
inclusion criteria: * patients between ages 18 years - 55 years. * solitary unilateral ureteral stone * stone sizes less than 10 mm measured on non-contrast computed tomography of kidney, ureter and bladder. * stones being treated primarily with medical expulsive therapy * radio opaque stone exclusion criteria: * pregnancy * untreated uti * bleeding disorders * obstruction distal to stone * serum creatinine \> 1.3 mg/dl in males and \> 1.2 mg/dl in females. * congenital renal anomaly/ skeletal malformation * previous treatment for the same stone (pcnl/ urs / push back) * solitary kidney * prior jj stent insertion * bilateral ureteral stone
feasibility of outpatient appendectomy for acute appendicitis

Conditions: Acute Appendicitis

Summary: the aim of our monocentric prospective in intention-to-treat study is to evaluate the feasibility of outpatient appendectomy for non complicated acute appendicitis.

acute appendicitis is one of the most common surgical emergencies and corresponds to an high number of admissions (about 120.000) in france. it mainly affects young adults and is associated to fewer complications and to a short length of stay. the notion of outpatient refers to a shorter hospital length to stay i.e. less than 12 hours without an overnight hospitalization. this notion came from 3 learned society recommendations' (sfcd, achbt, and afca) and has been considered as a national priority. there is no consensus about appendectomy in an outpatient setting.

Eligibility criteria:
inclusion criteria: * non complicated acute appendicitis which has been diagnosed at physical, paraclinical and morphological examination * adult patient * patient with sufficient understanding * good compliance with medical prescription * hygiene and housing equivalent to a hospitalization * availability of an accompanying able to prevent the surgeon if necessary, to accompany the patient and stay at night next to him * less than one hour from an health care adapted to the surgical structure * quick access to a telephone * patient affiliated with social protection exclusion criteria: * complicated appendicitis * pregnancy or breastfeeding * unstable vital signs or fever * objective signs of diffuse peritonitis * ward of court or prisoners * discovery of a complicated shape (severe sepsis, abscess, generalized peritonitis) * discovery of an alternative diagnosis * performing an associated gesture (colectomy or typhlectomy, annexectomy...)

Keywords: appendectomy acute appendicitis outpatient
continuous monitoring of patients with chronic obstructive pulmonary disease

Conditions: COPD

Summary: an open, single group, single center study to confirm ctc-actiwise™ as a means to record and monitor the progression of a patient's copd. chronic obstructive pulmonary disease (copd) affects growing patient groups. current knowledge about the disease limits the investigators ability to cure or interfere with the progression of the disease. copd is often characterized by exacerbating infections requiring emergency care. the project aims to examine whether disease progression of copd can be better controlled by continuously monitoring the patient's physical activity, along with the assessment of pulmonary symptoms and lung function. a key question is: can investigators find indicators that provides support for early intervention before severe symptoms arise. the patient carries a smartphone that records physical activity real-time, daily lung function measures, lung disease related symptoms, and use of medication. the experimental phase, the first part of the project, covers 25 copd patients followed up to 12 weeks where the primary objective is to examine and verify both new investigational methodology and technology.


Eligibility criteria:
inclusion criteria: * female or male 40 years of age and above * ability to use a smartphone and bluetooth spirometer * subjects having copd * ongoing treatment for a recent and not completely recovered copd exacerbation exclusion criteria: * dominating physical disability for other reasons or not related to copd
chinese auriculotherapy on stress and quality of life in nursing professionals: randomized clinical trial

Conditions: Stress; Quality of Life

Summary: the purpose of this study is to assess stress levels and quality of life in the nursing team of samaritan hospital and evaluate the effectiveness of chinese auriculotherapy used with and without closed protocol on reducing the stress levels and improvement of life quality.

based on the positive results achieved in a preliminary study conducted in january and february 2010, entitled "applicability of auricular needles or seeds for the reduction of stress in nursing professionals" at the university hospital, emerged from this research project in order to extend the first study, with a more representative sample and with a design that would allow further discussions on the effectiveness of chinese auricular needles semi-permanent to reduce stress and thereby improving the quality of life of nursing professionals. this clinical trial aims, above all, compare the results of the technique with the use of closed protocol and a group without protocol. the latter, however, shall be based on energy evaluation according to traditional chinese medicine (tcm) and the course of treatment will be performed similarly to the clinical practice commonly performed by traditional practitioners, that is, individually, not necessarily repetitive and whose continuation is achieved depending on the answers to each treatment. discussions are justified about protocol and no protocol research in complementary and integrative practices, since the methodologies proposed and accepted by the scientific community does not always seem to be appropriate tools for evaluating therapies like those coming from the east. the transfer of the western conception of research according to positivist principles are not always consistent with the principles underlying the complementary and alternative therapies, and in particular the practice from china.

Eligibility criteria:
inclusion criteria: score by the list of stress symptoms (40 to 95 points) voluntary participation in the study availability of time for submission to the sessions exclusion criteria: pregnancy medical license or vacation during the period if they perform another chinese treatment like a massage, acupuncture, moxibustion etc

Keywords: stress quality of life