Kornimate/medical-research-clean huggingface dataset:
recovery of ventilation after anesthesia for laparoscopic nephrectomy

Conditions: Ventilatory Depression; Postoperative Respiratory Complication

Summary: the purpose of this randomized, controlled feasibility investigation is to characterize pharmacologically induced ventilatory depression after anesthesia and examine how is affected by the amount of supplemental oxygen patients are receiving in the immediate postoperative period.

the purpose of this study is characterize pharmacologically induced ventilatory depression after anesthesia and examine how is affected by the amount of supplemental oxygen patients are receiving in the immediate postoperative period, since hyperoxemia (ie., higher than necessary partial pressure of oxygen in the arterial blood) has been associated with ventilatory depression via suppression of the hypoxic ventilatory drive. in this feasibility randomized controlled trial, the investigators plan to estimate and compare the cumulative segment of time during which the transcutaneous partial pressure of carbon dioxide will exceed an upper limit of 45 mmhg (i.e., tcpco2 \> 45 mmhg) for the 90-min-long post-anesthesia period, between the conventional (titrated to an oxygen saturation \> 96%) and the conservative (titrated to o2 saturation 90 -94%) o2 supplementation interventions. hypothesis: conservative use of o2 (titrated to an spo2: 90 - 94%), will be associated with less hypoventilation (i.e., less time spent with an tcpco2 \> 45 mmhg) during recovery from general anesthesia, compared to liberal o2 supplementation (spo2 \> 96%).

Eligibility criteria:
inclusion criteria: * american society of anesthesiologists (asa) physical status i-iii * body mass index (bmi) less than 40 kg/m2 * scheduled to undergo robotic-assisted radical laparoscopic nephrectomy. exclusion criteria: * patients with a diagnosis of chronic obstructive pulmonary disorder (copd), severe neurological, cardiopulmonary, psychiatric, or untreated thyroid disorder * chronic pain condition that is being treated with opioids * patients with a hematocrit lower than 30% at the end of surgery, or those with an excessive blood loss, requiring transfusion of blood products during their surgery, will be also excluded from the study.
amodiaquine+artesunate for uncomplicated malaria treatment

Conditions: Uncomplicated Malaria

Summary: this is a phase iv one-arm study aiming at recruiting 50 patients to assess the efficacy of aq+as in patients with a positive rdt diagnosis of malaria in nanoro, burkina faso.


Eligibility criteria:
inclusion criteria: * males and females aged 6 months and above. * body weight of 5 kg and above. * rdt positive test. * fever (axillary temperature at ≥ 37.5°c) or history of fever in the previous 24 hours. * signed (or thumb-printed whenever patients are illiterate) informed consent. * patients' willingness and ability to comply with the study protocol for the duration of the study. exclusion criteria: * participation in any other investigational drug study (antimalarial or others) during the previous 30 days. * known hypersensitivity to the study drugs. * severe malaria. * danger signs: not able to drink or breast-feed, vomiting (\> twice in 24hours), recent history of convulsions (\>1 in 24h), unconscious state, unable to sit or stand. * known intercurrent illness or any condition (cardiac, renal, hepatic diseases) which in the judgement of the investigator would place the subject at undue risk or interfere with the results of the study. * severe malnutrition (defined as weight for height \<70% of the median nchs/who reference).
effect of recent ejaculation on scrotal duplex parameters in infertile males with varicocele

Conditions: Varicocele

Summary: evaluate the effect of recent ejaculation on scrotal duplex parameters in infertile males with varicocele

varicocele is abnormal dilatation of the pampiniform plexus veins draining the testicles. it manifests as an abnormal retrograde flow in the internal spermatic venous system or dilation of venous branches in the external cremasteric system . it affects approximately 15% in the general population, 35 - 40% in men with primary infertility and approximately 80% of men with secondary infertility. it could often concomitantly occur with infertility or chronic scrotal pain causing impaired spermatogenesis and is the most common correctable cause of male infertility. it may affects spermatogenesis via different mechanisms such as increased testicular heat, hormonal disorders and reflux of toxic metabolites. scrotal colour doppler ultrasonography (usg) is a widely used method for evaluation of varicocele patients . it can be used along with physical examination in these patients through evaluation of vein reflux and diameter; in cases where palpation may be problematic. furthermore, the degree of reflux and vein diameter can be used during the decision-making stage while treating varicocele . ejaculation is the process by which sperms move from epididymis via vas deferens to urethra and finally expelled out through the urethral meatus by the contraction of smooth muscles. a normal antegrade ejaculation consists of emission, expulsion (ejection), and orgasm . in the evaluation of infertile patients, semen analysis is required for evaluation of number, motility and morphology of spermatozoa with scrotal colour doppler usg. ejaculation for the purpose of sperm analysis is known to significantly increase testicular blood supply .

Eligibility criteria:
inclusion criteria: 1. infertile male patients. 2. patients with scrotal varicocele. 3. male patients aging over 18 years old. exclusion criteria: 1. pyospermia. 2. epididymitis. 3. orchitis. 4. anejaculation. 5. recurrent varicocele. 6. patients who previously underwent scrotal or inguinal surgery.
role of drain in decreasing postoperative complications

Conditions: Cesarean Section Complications

Summary: postoperative complications are common after cesarean section

wound infection can occur after cesarean section

Eligibility criteria:
inclusion criteria: women undergoing cesarean section exclusion criteria: * women who deliver by normal vaginal delivery
chronic ankle instability, surgical repair: open versus closed

Conditions: Chronic Ankle Instability

Summary: rationale: lateral ankle ligament injuries may be a result of ankle sprains. in 10-30% of patients with lateral ankle ligament injuries, chronic lateral ankle instability may be present. if conservative treatment fails, instability is treated surgically. anatomic repair (also known as the bröstrom procedure) is the current golden standard for surgical treatment of chronic ankle instability. the bröstrom started out as an open technique and is now also performed arthroscopically. both approaches are considered standard care and provide good results. which approach is best, has not yet been researched. in this study it is hypothesized arthroscopic repair provides better functional outcome compared to open repair during short term follow-up. objective: the main objective of this study is to compare the functional outcome after arthroscopic and open anatomic repair in patients with chronic lateral ankle instability, and secondly to assess ankle stability and ankle range of motion (rom) after arthroscopic and open ligament repair. study design: a non-blinded prospective randomized controlled trial study population: all patients willing to participate, from an age of 18 years old, with persisting ankle instability for at least 6 months, eligible for anatomic repair. intervention: both groups of patients are surgically treated with anatomic repair of the anterior talofibular ligament (atfl). one group is treated arthroscopically and the other by the open approach. main study parameters/endpoints: the primary outcome measure is functional outcome 6 months after surgery measured using the foot and ankle outcome score. the main study parameter is a difference of ≥10 2 points per faos subscale between both treatment groups (minimal important change = 10 points; 2 per subscale).


Eligibility criteria:
inclusion criteria: * patients are 18 years or older; * experience pain and/or a sensation of instability during sports and/or daily activity; * isolated lateral ankle instability; * planned for surgical repair of the atfl; * at least one previous episode of an ankle inversion sprain; * complaints for at least 6 months; * failed previous conservative treatment. exclusion criteria: * serious concomitant injury (like arthrosis, ruled out using an ap and lateral x-ray according to standard protocol); * foot or ankle fracture in past; * previous foot or ankle surgery; * rom restriction of \>10 degrees; * medial instability; * severe misalignment; * ankle/foot deformities (e.g. severe flat foot); * systemic comorbidity leading to delayed recovery (e.g. diabetes mellitus, rheumatoid arthritis) * (general) hyper laxity * inability or unwillingness to provide consent * present factors that may cause difficulty of follow-up

Keywords: instability ankle surgical stabilization
treat autosomal dominant polycystic kidney disease with oral ketone ester?

Conditions: ADPKD

Summary: the investigators are running a study to see if a special drink, called a "ketone ester", can help people with a type of kidney disease named "autosomal dominant polycystic kidney disease" or adpkd for short. the investigators want to find out: if it's easy for patients to take this drink every day for about 2 months. if it's safe and doesn't cause any problems. if it makes a difference in the size and function of the kidneys. who can join? people between 16 to 70 years old who have adpkd. those with a certain amount of kidney size and function. people who haven't been on specific diets or lost a lot of weight recently. women who are not breastfeeding and are using birth control. people with a body weight that is not too low or too high. who cannot join? people who've been on a high-fat diet or skipped meals for a while recently. those with other health conditions like diabetes or certain metabolic issues. anyone who has a problem with getting an mri scan. if participants are in another medical study right now. the study will happen in two belgian hospitals and is supported by the uz brussel's nephrology department. the investigators hope to include 20 people and start in november 2023.


Eligibility criteria:
inclusion criteria: * - adpkd patients (diagnosis based on genetics or imaging) ≥ 16 and ≤ 70 years. * total kidney volume ≥ 600 ml. * egfr (ckd-epi) ≥ 30 ml/min/1.73m2. * normal blood glucose, hba1c and ketones. * women of childbearing potential who are non-lactating and using an effective form of birth control. * stable disease-modifying treatment for the last 2 months. * well controlled hypertension (stable antihypertensive medications for at least 2 months). * bmi \> 18 \< 30. * written informed consent. exclusion criteria: * exposure to a ketogenic diet or intermittent fasting for more than 2 weeks within 6 months before inclusion. * significant weight-loss (\> 10%) within 6 months before inclusion. * diabetes mellitus. * conditions prohibiting the use of a ketogenic diet (liver damage, pancreatic failure, pyruvate-carboxylase deficiency, defects in fatty acid oxidation/gluconeogenesis/ketolysis/neogenesis, hyperinsulinism), based on patient history. * diagnosis with any disorder of fatty acid metabolism based on patient history. * eating disorder. * alcohol abuse. * contraindication for mri. * participation in other interventional trial.

Keywords: ketone ester
low dose liraglutide and metformin vs. high dose liraglutide alone in treatment of obesity

Conditions: Polycystic Ovary Syndrome; Obesity

Summary: weight reduction is the most important treatment target when polycystic ovary syndrome (pcos) is linked to obesity. liraglutide (lira) in dose of 3 mg was recently approved as an anti-obesity drug. metformin could enhance weight lowering potential of liraglutide. we investigates short term interventions with low dose liraglutide in combination with metformin and high dose liraglutide alone influence on significant weight reduction in obese women with pcos.


Eligibility criteria:
inclusion criteria: * 18 years old to menopause * polycystic ovary syndrome (nichd criteria) * bmi of 30 kg/m² or higher exclusion criteria: * type 1 or type 2 diabetes mellitus * history of carcinoma * cushing's syndrome or congenital (non-classic) adrenal hyperplasia * personal or family history of men 2 * significant cardiovascular, kidney or hepatic disease * the use of medications known or suspected to affect reproductive or metabolic functions * the use of statins, within 90 days prior to study entry
effects of sleep loss on endothelial function and cytokine levels in internal medicine residents

Conditions: Sleep Deprivation

Summary: work requirements for medical trainees result in substantial sleep loss. sleep loss has been associated with increased levels of certain inflammatory hormones that could have negative impact on blood vessel function. the purpose of this study is to determine the effects of sleep loss on blood hormone levels and blood vessel function in medical trainees.

context: sleep loss is associated with increased blood levels of interleukin-6 (il-6) and c-reactive protein (crp). medical residents are often deprived of normal sleep during extended work shifts, but the effects of work-related sleep loss on biomarkers of vascular inflammation and function are unknown. objective: we sought to test the hypothesis that sleep loss during extended work shifts during medical training is associated with increased circulating levels of pro-inflammatory biomarkers and evidence of vascular dysfunction. design: outcome measures were assessed after extended 30-hour work shifts and non-extended 6-hour work shifts in a single-blind, randomized crossover design. setting: university hospital medical intensive care unit patients or other participants: twenty-two healthy medical residents were studied during a medical intensive care unit rotation. main outcome measure(s): sleep related cytokines (interleukin-6 and tumor necrosis factor), serum markers of vascular inflammation (c-reactive protein), and flow-mediated dilation in the brachial artery.

Eligibility criteria:
inclusion criteria: * medical resident in micu rotation * non-smoker * body mass index \<28 kg/m2 exclusion criteria: * systolic blood pressure \>140 mmhg; diastolic blood pressure \>90 mmhg * known history of diabetes mellitus, hypertension, hyperlipidemia * known history of acute or chronic inflammatory or infectious disease * known history of sleep disturbance unrelated to work * pregnancy

Keywords: inflammation mediators [d23.469] cardiovascular physiologic phenomena [g09.330.553]
new version pulmicort turbuhaler usa adults

Conditions: Asthma

Summary: a comparison of the safety, efficacy and budesonide pharmacokinetics of the currently approved pulmicort turbuhaler with a new version of the inhaler, in adult patients who have asthma and are currently being treated with inhaled steroids. in addition the study evaluated the functionality of the new inhaler at the end of its intended life.


Eligibility criteria:
inclusion criteria: * males and females at least 18 years old with a diagnosis of asthma (as defined by the ats) for at least 6 months. * to enter the run in period, subjects were also required to have the following: * a forced expiratory volume (fev1) in 1 second of 60% to 90% of predicted normal, airway reversibility of at least 12% and 0.20 l, use of orally inhaled corticosteroids for at least 3 months prior to the study. * at visit 2, subjects who met additional entry criteria related to rescue medication use and asthma symptom scores during the run in period plus visit specific fev1 requirements were assigned to randomized treatments exclusion criteria: * life threatening asthma, two or more overnight hospitalisations for asthma within 1 year or any emergency room visit for asthma within 6 months of starting study. * use of steroid tablets or injections during the month (28 days) prior to visit 1 and use of other asthma medicines (except rescue medication) within 2 weeks prior to the study. * any acute exacerbation of asthma or a respiratory tract infection within 30 days prior to the study. subject must not smoke or have smoked within 6 months of the study.

Keywords: asthma pulmicort turbuhaler budesonide flexhaler
computerized cognitive behavior therapy in treating depression in patients with cancer

Conditions: Major Depressive Disorder

Summary: this randomized clinical trial studies how well a computerized cognitive behavior therapy program works in treating depression in patients with cancer. the cognitive behavior therapy program uses a series of internet-delivered sessions intended to help patients identify and change problematic patterns of thinking and behavior that maintain depression.

primary objectives: i. establish the efficacy of computerized cognitive behavior therapy ("beating the blues") in reducing symptoms of depression and remission of major depressive disorder (mdd) in cancer patients. ii. test the feasibility of implementation and patient acceptability of online computerized cognitive behavior therapy for cancer patients with major depressive disorder (mdd). iii. test moderators (cancer specific stress, mdd history, anxiety disorder comorbidity, and homework compliance) of treatment outcome. outline: patients are randomized to 1 of 2 groups. group i (immediate treatment): patients undergo computerized cognitive behavior therapy consisting of 45-60 minute sessions once per week for 8 weeks. patients also complete the patient health questionnaire-9 (phq-9) and generalized anxiety disorder-7 (gad7) at weeks 1, 3, 5, 7 and 8 and complete other questionnaires for 15-30 minutes each that assess psychosocial and physical symptoms. group ii (wait-list): patients are placed on an 8-week wait-list and then undergo computerized behavior therapy and receive questionnaires as in group i. after completion of study intervention, patients are followed up at 2, 4, and 6 months.

Eligibility criteria:
inclusion criteria: * a current/prior cancer diagnosis * a principal diagnosis of major depressive disorder (mdd) * able and willing to give informed consent * have access to a computer with an internet connection at home exclusion criteria: * history of bipolar affective disorder or psychosis * history of substance dependence in the past six months * subnormal intellectual potential (intelligence quotient \[iq\] below 80) * current suicide risk or significant intentional self-harm in the last six months sufficient to preclude treatment on an outpatient basis * inability to read and write english

Keywords: cancer depression
development of a rapid diagnostic test to identify crimean-congo haemorrhagic fever at the point-of-care

Conditions: Crimean-Congo Haemorrhagic Fever

Summary: the goal of this medical device diagnostic evaluation study is to determine if this novel lateral flow device can detect crimean-congo hemorrhagic fever (cchf) at the point of care in secondary health care clinics in turkey. the main outcome is to determine the sensitivity and specificity of the tests for cchf in samples of whole blood, serum and capillary blood compared to a gold-standard of pcr for participants that present at 4 endemic sites secondary health care clinics in turkey in 492 adults who are suspected to have been infected with cchf. the study aims to hopes to achieve at least the minimum required sensitivity of 90 % and specificity of 80 % as required by the who.


Eligibility criteria:
inclusion criteria: participants aged 18 years or older suspected cchf infection that requires a rt-pcr diagnosis and venous blood draw willingness to comply with study procedures and consent to the study presents at 1 of 4 listed sites exclusion criteria: * in the investigators opinion should not be enrolled onto study (e.g., medical prudence or capacity)

Keywords: cchf medical device lateral flow rapid diagnostic test lft rdt
preterm lung function and exercise response measured by oep

Conditions: Premature Birth

Summary: this study will explore lung function and respiratory health in school-aged children who were born prematurely at \<32 weeks gestation. it will involve full lung function assessment, a questionnaire and discussion about respiratory health, and an exercise test using optoelectronic plethysmography (oep) to measure breathing patterns.

preterm are born during a critical stage of lung development, and can have abnormalities in lung function that persist with age. previous studies have shown that children with bpd have reduced lung function and limited exercise capacity. these studies have used conventional lung function testing which requires a tight fitting mask. this is uncomfortable, may alter normal breathing patterns and cannot measure changes in total lung volume. optoelectronic plethysmography (oep) indirectly measures lung volumes and breathing patterns using cameras to track the position of marker stickers on the chest, back and abdomen. it is comfortable, does not require a mask and allows us to track changes in total lung volume. this study will use standard lung function testing and oep to measure lung function and breathing patterns at rest and during exercise in school-aged children born prematurely, compared to healthy children born at full term. all participants will complete standard lung function tests, a questionnaire and structured interview to qualitatively assess respiratory health, and an exercise test using oep to assess how breathing changes with exercise.

Eligibility criteria:
inclusion criteria: * age 8-16 years * born at \ 37 weeks gestation (controls) * parental consent obtained exclusion criteria: * unable to comply with test procedure * respiratory illness within last 2 weeks * cardiac disease (excludes ligated pda) * neuromuscular disease

Keywords: lung function exercise