Kornimate/medical-research-clean huggingface dataset:
reduction of cord blood transplantation toxicity in patients with acute myeloid leukemia

Conditions: Acute Myeloid Leukemia

Summary: multicentric evaluation of the reduction of unrelated cord blood transplantation (ucbt) toxicity by using reduced intensity conditioning (ric) in patients with acute myeloid leukaemia.ucbt related mortality and morbidity were limiting factors for the development of this procedure in adults. non myeloablative conditioning regimen showed promising results and prospective evaluation has to be developed to confirm these retrospective data.

individual meta-analysis is planned to compare geno-identical transplantation with myeloid-ablative or non myeloid-ablative conditioning with ucbt after ric.

Eligibility criteria:
inclusion criteria: * ages : 4 to 65 * de novo or secondary aml requiring allogeneic transplant * no donor (related or unrelated) compatible 10/10 * complete remission excepted cr1 with t(8;21) or inv (16) or t (15;17) * smouldering aml without progression * signed assent of recipient exclusion criteria: * if cr1: aml with with t(8;21) or inv (16) or t (15;17) * karnofsky \< 50% - clearance of creatinin \< 40 ml/min * transaminases \> 8 n * previous autologous or allogeneic transplantation within 6 month prior to the study (except if tandem) * total body irradiation contra-indicating 2 gy tbi * local irradiation contra-indicating 2 gy tbi

Keywords: cord blood transplantation conditioning regimen acute myeloid leukaemia sorror comorbidity index quality of life innate immunity immune reconstitution post transplant umbilical cord blood stem cell transplantation hematopoietic stem cell transplantation
dwi in the diagnosis of histological types of nephroblastoma in children

Conditions: Nephroblastoma (Wilms Tumour)

Summary: initially, or after preoperative chemotherapy, patients with a kidney tumor are examined on 3t mr scanner or 1.5t mr scanner. a standard mri study of the abdomen with contrast enhancement is performed. dwi (diffusion weighted) images are included in the standard investigation package and consist of diffusion maps. then, using philips workstation (isp 9.0, philips, netherlands), dwi mapping and adc values collection (mm2/s) are performed. the placement of region of interest (roi) is selected in the kidney mass in a solid and cystic area with a size up to 100 mm2. after the preoperative abdomen mri, a surgical treatment is performed. histological material is directed to the pathologist, who carried out the histological staging by the malignancy degree (low, intermediate, high). the data is entered into the database and the relationship between adc values and histological degrees of malignancy of nephroblastoma is investigated

initially, or after preoperative chemotherapy, patients with a kidney tumor are examined on 3t mr scanner or 1.5t mr scanner, using 8-channel body coil. a standard mri study of the abdomen with contrast enhancement is performed. dwi (diffusion weighted) images are included in the standard investigation package and consist of diffusion maps (dwi 3b) with 3 b-factors (50; 600; 800 or others, optional). then, using philips workstation (isp 9.0, philips, netherlands), dwi mapping and adc values collection (mm2/s) are performed. the placement of region of interest (roi) is selected in the kidney mass in a solid and cystic area with a size up to 100 mm2. the values are entered in the table due to the stage of the chemotherapy. after the preoperative abdomen mri, a surgical treatment is performed. histological material is directed to the pathologist, who carried out the histological staging by the malignancy degree (low, intermediate, high). the data is entered into the database and the relationship between adc values and histological degrees of malignancy of nephroblastoma is investigated.

Eligibility criteria:
inclusion criteria: 1. age under 18 y.o.; 2. renal mass with confirmed histology. exclusion criteria: 1. absolute contraindications to magnetic resonance imaging (pacemaker, ferromagnetic implants, etc.); 2. refusal to sign the informed consent.

Keywords: paediatric oncology kidney dwi mri nephroblastoma wilms tumour quantitative estimation
i prevent - irbesartan in hypertensive diabetic patients

Conditions: Hypertension

Summary: * to evaluate blood pressure (bp) reduction to the targeted values (systolic bp ≤ 130 mmhg and diastolic bp ≤ 80 mmhg) in hypertensive type 2 diabetic patients. * to evaluate the benefit of irbesartan in the reduction of microalbuminuria from baseline (if any at the inclusion visit) in this population. * to demonstrate the safety of irbesartan in this population.


Eligibility criteria:
inclusion criteria: * proven hypertensive type 2 diabetic patients with hba1c \> 6% and ≤ 10% (with or without microalbuminuria). * newly diagnosed "naïve" hypertensive patients (no prior treatment for hypertension). or, * patients who were receiving antihypertensive agents (maximum two agents, including one diuretic) with blood pressure targets achieved, yet, in the investigator's opinion, those patients would benefit more from switching to the study medication. these patients will undergo a wash out period for not less than 7 days prior to enrollment. exclusion criteria: * severe hypertension (sbp ≥ 180 mm hg or dbp ≥ 110 mm hg). * patients with secondary hypertension. * patients with uae \> 200µg / min. * patients with hba1c \ 10%. * significant chronic renal impairment (serum creatinine \> 2.0 mg/dl). * significant liver disease as shown by sgpt/sgot (alat/asat) \> 2.5 times the upper limit of the normal range. * currently pregnant or lactating females. * women of childbearing potential not protected by effective contraceptive method of birth control and/or who are unwilling or unable to be tested for pregnancy. * any patient who is in need for a combination antihypertensive therapy from the start (from the medical point of view of his/her physician). * known hypersensitivity to irbesartan, other arbs(angiotensin receptor blockers), hydrochlorothiazide, or other thiazide diuretics. * patients with malignancy during the past 5 years, known collagen disease or severe cardiac, cerebrovascular or gastric disease. the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
economic analyses of the reduce trial

Conditions: Neoplasms, Prostate; Benign Prostatic Hyperplasia; Cancer

Summary: the objective of this project is to conduct a retrospective economic analysis of the use of dutasteride for the prevention of prostate cancer based on data from the reduce clinical trial. reduce is a 4-year, phase 3, randomized, double-blind, parallel assignment clinical trial of the use of dutasteride compared with no chemopreventive treatment. the reduce trial was a four-year, international, multicenter, randomized, double-blind, placebo-controlled, parallel group study. there were 790 investigators in 42 countries.


Eligibility criteria:
inclusion criteria: * men aged 50 to 75 years * serum prostate-specific antigen (psa) ≥2.5 ng per milliliter and ≤10 ng per milliliter (men aged 50-60 years) or ≥3.0 ng per milliliter and ≤10 ng per milliliter (men aged \>60 years) * single, negative prostate biopsy (6-12 cores) within 6 months prior to enrollment (independent of the study) exclusion criteria: * principal exclusion criteria were more than one prior prostate biopsy * high-grade intraepithelial neoplasia (hg-pin) or atypical small acinar proliferation (asap) on the pre-entry prostate biopsy * a prostate volume \>80 ml, previous prostate surgery * international prostate symptom score (ipss) ≥25 or ≥20 if already on alpha-blocker therapy for bph

Keywords: cost effectiveness dutasteride elevated risk population prostate cancer prevention
a clinical trial to evaluate the efficacy and safety of hl301 versus umkamin tab in acute bronchitis patients

Conditions: Acute Bronchitis

Summary: a multicenter, randomized, double-blinded, active-controlled, parallel, phase iii clinical trial to evaluate the efficacy and safety of hl301 versus umkamin tab. in acute bronchitis patients endpoint: bss, the improvement and improvement rate of the tester for the treatment response, the satisfaction of the subject


Eligibility criteria:
inclusion criteria: 1. both gender, 19 years ≤ age ≤ 80 years 2. (bronchitis severity score)\* ≥ 5point at visit 2 (randomized visit) 3. acute bronchitis within 48hr based on visit 2 (randomized visit) 4. those who can comply with the requirements of clinical trials 5. written consent voluntarily to participate in this clinical trial exclusion criteria: 1. patients with respiratory and systemic infections requiring systemic antibiotic therapy 2. patients with bleeding tendency 3. patients who investigators determines to severe respiratory disease that would interfere with study assessment 4. patients who were treated with oral systemic adrenocortical hormone or immunosuppressive drug within 4 weeks prior to visit 2 5. patients who were treated with oral antihistamines, ace suppressive. or systemic/inhalative glucocorticosteroid within 2 weeks prior to visit 2

Keywords: acute bronchitis
attenuation imaging in hepatic steatosis

Conditions: Hepatic Steatosis; Obesity, Childhood; Ultrasonography

Summary: for obese and normal-weight children, the investigators assess the diagnostic performance of attenuation imaging (ati) in the detection of hepatic steatosis in children.


Eligibility criteria:
inclusion criteria: * bmi of 85th percentile or less exclusion criteria: * congenital anomaly including heart, intestine, kidney * acute hepatitis * congenital hepatic anomaly
enb robotic icg guided surgery: a novel technique for targeting small lung tumors

Conditions: Non-small Cell Lung Cancer; Thoracic Surgery

Summary: lung cancer is the leading cause of cancer deaths worldwide. however, if diagnosed at an early stage (tumor \<2 cm), lung cancer is highly curable with a 5-year survival rate greater than 80% after surgical resection. screening tests have made it easier to identify small lung tumors. however, these tumors are often not visible to the naked eye, and surgeons cannot feel them, making them difficult to precisely locate and remove. for this reason, surgeons have become more reliant on image guided surgery for the removal of these tumors. the standard of care for locating and removing small lung tumors is microcoil-guided video-assisted thoracoscopic surgery (vats). this is a two-step procedure performed by two separate physicians. * first, patient is taken to radiology suite and radiologist inserts a microcoil near the lung tumor * second (usually occurs a few hours later), patient is taken to operating room; a surgeon uses an x-ray arm to find the microcoil within the lung and remove it surgically. a pathologist reviews the resected tissue to make sure that the tumor and the microcoil were both removed. until this evaluation, the surgeon does not know whether the tumor has been removed or not. while this method is safe, it is time consuming, uses staff resources, and requires bulky equipment to complete. in this study, we plan to develop and test a new method of identifying and removing small lung tumors. this procedure is called electromagnetic navigational bronchoscopy (enb) robotic indocyanine green guided surgery (riggs) or enb-riggs for a short name. the purpose of this study is to test the safety and reliability of the enb-riggs surgery in the form of a pilot study. enb-riggs surgery is done in the operating room by a surgeon under general anesthetic. enb-riggs begins by creating a 3-d gps map of the lung which guides the surgeon directly to the tumor. a fluorescent green dye called indocyanine green is then injected into the tumor, and when viewed by the special robotic camera the tumour will fluoresce with a green hue allowing the surgeon to easily see the tumour. the surgeon then uses the robot to remove the tumor and surrounding tissue. the lung tissue specimen will be evaluated immediately by a pathologist.


Eligibility criteria:
inclusion criteria: 1. age \> 18 years 2. peripheral lung tumour that is \<2 cm in size on a ct scan 3. fit to undergo thoracic surgery as assessed by the surgeon. exclusion criteria: 1. hypersensitivity or allergy to icg, sodium iodide or iodine 2. women who are currently pregnant or are breast feeding; or women of child bearing potential who are not currently taking adequate birth control.

Keywords: robotic surgery indocyanine green electromagnetic navigational bronchoscopy
effects of femoral vs saphenous nerve blocks on function after acl repair

Conditions: Anterior Cruciate Ligament

Summary: the primary objective of the study is to compare motor strength in knee extension between two groups of patients. one group receiving a proximal thigh block of the femoral nerve, and one receiving a distal thigh block of the saphenous nerve. the secondary objective is to compare the pain relief and functional outcomes in these two groups.


Eligibility criteria:
inclusion criteria: 1. age 18-65 2. upcoming acl reconstruction using patellar tendon autograft scheduled at hershey medical center or the hershey outpatient surgical center (hosc) exclusion criteria: 1. documented neuropathy 2. skeletally immature 3. previous knee surgery 4. inability to provide informed consent 5. acl reconstruction with other tendon repairs

Keywords: nerve blocks in anterior cruciate ligament surgery
quantitative methods for supplementing contrast-enhanced magnetic resonance imaging of breast cancer

Conditions: Breast Cancer

Summary: contrast-enhanced magnetic resonance imaging (ce-mri) is now established as the most accurate non-invasive imaging modality for characterizing breast cancer. ce-mri has a very high sensitivity because the intravenous mr contrast agent highlights regions with increased vascularization and vascular permeability compared to normal breast tissues and benign lesions.

contrast-enhanced magnetic resonance imaging (ce-mri) is now established as the most accurate non-invasive imaging modality for characterizing breast cancer. ce-mri has a very high sensitivity because the intravenous mr contrast agent highlights regions with increased vascularization and vascular permeability compared to normal breast tissues and benign lesions. while research continues on improving the specificity of ce-mri, several other mr techniques that do not require an exogenous contrast agent have been shown to provide valuable information that can improve the characterization of breast cancers. these techniques include magnetic resonance spectroscopy (mrs), diffusion-weighted imaging, and water t2 relaxometry. the long-term goal of this study is to develop these techniques to produce quantitative mr-based biomarkers that can be used to supplement or possibly supplant the information provided by ce-mri. this project seeks to facilitate the advancement of these advanced, non-contrast techniques. this study uses a piggyback design, in which subjects who are already scheduled to receive a ce-mri study are invited to receive an additional 10-20 minutes of scanning to help develop these novel methods. this efficient design allows for the refinement and assessment of these new techniques with a minimum of risk and inconvenience to the patient. with these proposed improvements, these techniques may lead to quantitative biomarkers that can guide critical clinical questions in treatment response, diagnosis, staging, and high-risk screening of breast cancer.

Eligibility criteria:
inclusion criteria: * women scheduled and eligible to receive a contrast-enhanced breast mri at the umn center for clinical imaging research for either standard clinical care, or participation in the ispy2/acrin6698 clinical research study * age 18 years or older * ability to read and understand english * ability to provide written informed consent exclusion criteria: * subjects who are unlikely to tolerate the longer mri scanning duration. this may include, history of discomfort during mri scanning, anxiety, or claustrophobia

Keywords: breast cancer magnetic resonance spectroscopy diffusion weighted imaging
evaluation of the effect of hfmt in promoting donor-site wound healing

Conditions: Wound Heal

Summary: autologous hair transplantation involves follicle extraction, trimming, and implantation. follicle trimming improves efficiency and postoperative appearance, resulting in the discarded tissue known as hair follicle-derived microtissue (hfmt). in a clinical case, hfmt homogenate was applied to the fue donor area wound, resulting in reduced pain, relief from itching, and faster healing compared to conventional treatment. this study aims to compare the effects of hfmt on fue donor area wound healing.

the process of autologous hair transplantation involves three steps: fue follicle extraction, follicle trimming, and follicle implantation. the purpose of follicle trimming is to improve the efficiency of follicle implantation and enhance the immediate postoperative aesthetic appearance. therefore, during the follicle trimming process, the sebaceous glands and above-mentioned epidermis, partial dermis tissue, and surrounding tissue of the follicles are usually separated and discarded, and the remaining follicle tissue is implanted into the recipient area. the investigator collectively refers to the discarded tissue as hair follicle-derived microtissue (hfmt). in a clinical case, the investigator accidentally discovered that if the hfmt obtained from the follicular unit extraction (fue) method was collected, cut into pieces, and made into tissue homogenate, and then the hfmt homogenate was used to cover the fue donor area wound, the patient reported reduced postoperative pain and some relief from skin itching. additionally, compared to conventionally treated wounds, the wound in the donor area healed faster. based on these findings, this study aims to compare the effects of hfmt on the healing of fue donor area wounds.

Eligibility criteria:
inclusion criteria: * patients aged 18-60 years who underwent fue autologous hair transplantation. * the patient's liver and kidney function were normal, and the serum protein level before surgery was normal. exclusion criteria: * patients with a history of smoking. * those suffering from diseases that affect wound healing, such as diabetes or hyperglycemia. * those with abnormal blood sugar. * abnormal cardiopulmonary function. * there are foci of infection in or near the surgical area. * scar hyperplasia or scar constitution. * those with a history of neuralgia. * the patient took immunosuppressants, cytostatics, and hormonal anticoagulants before surgery and antibiotics.

Keywords: hair transplantation
the impact of employee wellness programs

Conditions: Health Behavior; Disease, Chronic

Summary: there is great public and private interest in the use of workplace wellness programs to reduce health care spending, improve health outcomes, and enhance productivity for employees. however, there is little rigorous evidence on the effects of wellness programs. this study partners with a large multi-state u.s. employer (bj's wholesale club) and an experienced wellness vendor (wellness workdays) to evaluate a multi-prong workplace wellness program, including components such as nutrition counseling, fitness challenges, and stress management workshops. the wellness program will be delivered by a team of experts including registered dieticians, and will include financial rewards for participation. the program will be available to employees in initially 20 of bj's 200 worksites, and later expanded to 25 worksites. these worksites have been randomly selected, allowing a randomized controlled trial evaluation of the effects of the wellness program. data will be collected on a wide array of outcomes from multiple sources, including on-site biometric screenings and surveys, employment records, and health insurance claims for employees at both treatment and control worksites.


Eligibility criteria:
inclusion criteria: * employed in one of bj's clubs during the period of the intervention exclusion criteria: * not employed in one of bj's clubs during the period of the intervention

Keywords: wellness prevention
compression bandaging and manual lymph drainage in women with lymphedema

Conditions: Arm Lymphedema After Breast Cancer

Summary: lymphedema is the result of accumulation of fluid and other elements in tissue spaces because of an imbalance between the production of fluid interstitial and transport. lymphedema can cause significant physical and psychological morbidity. prevalence of lymphedema in patients after breast cancer surgery is 12-60% and the incidence is 12-26%.psychological and social consequences of secondary lymphedema related breast cancer have been little recognized and documented. although, it have performed many studies related secondary lymphedema it not found sufficient evidence in the literature to suggest the most effective treatment. there is some evidence suggesting that compression therapy and manual lymphatic drainage can improve lymphedema but more studies are needed. the aim of this research is to to evaluate the clinical effect of multimodal treatment (compression bandaging and manual lymph drainage) versus applying manual lymphatic drainage in women with arm lymphedema after breast cancer surgery.

this study has two sub research: a quantitative approach and a qualitative approach. the research will be carried out by a multicenter way quantitative approach consist in carried out a single-blind randomized controlled trial of 44 women with arm lymphedema. patients will be distributed in two intervention groups by a randomized way. participants will be given his assignment by closed envelope. both treatments will be administered five days a week for six weeks. the experimental group (n=22) will receive multimodal treatment: combination of manual lymphatic drainage and compression bandaging. the control group (n=22) only will receive manual lymphatic drainage. we want to determinate the effect on volume arm decrease, quality of life, level of hand strength, degree of pain, fatigue level, and state of anxiety and depression. the influence on the lymphedema will be analyzed with lower limbs strength, physical activity, lung function, respiratory muscle strength by maximal inspiratory and expiratory pressure measurements (mip and mep) and cardiorespiratory functional capacity. patients adherence will be analyzed by a smartphone. qualitative apprach: to know the perceptions and experiences of the participants in both interventions groups through a qualitative descriptive study. data will be obtained with semi-structured depth interview.

Eligibility criteria:
inclusion criteria: * women between 45 and 65 years with secondary lymphedema in upper limb after breast cancer surgery. * cancer stages i-iii according to tnm classification of the american joint committee on cancer. exclusion criteria: * to have received lymphedema treatment previously. * to be treated by radiation therapy or chemotherapy. * distant metastases or local recurrence of cancer. * infectious signs in the upper limb with lymphedema. * uncontrolled hypertension. * heart disease.

Keywords: compression bandage, manual lymphatic drainage, lymphedema, breast cancer, qualitative research.