Kornimate/medical-research-clean huggingface dataset:
audio recording during laparoscopic surgery

Conditions: Perioperative/Postoperative Complications; Laparoscopy; Communication; Communication, Multidisciplinary

Summary: in september 2017 audio recording during laparoscopic general surgery was implemented as routine a lindesbergs hospital. the study was designed to observe operations before and after the introduction of audio recording. the main outcome of the study was time spent on non-relevant conversation.

in september 2017 audio recording during laparoscopic general surgery was implemented as routine a lindesbergs hospital. one single observer not working at the department observed consecutive operations before and after the introduction of audio recordings. all elective laparoscopic procedures were included. there was no available data to support a power-calculation why we intended to include 20 patients in each arm of the study. exclusion criteria were refusal of operating team or patient to participate in the study, or planned open surgery. potential disturbances were recorded by the observer. the main outcome was time with non-relevant conversation (for the operation or as part of education).

Eligibility criteria:
inclusion criteria: elective laparoscopic general surgery - exclusion criteria:r, planned open surgery, refusal to participate (patient or operating team) -

Keywords: non-relevant conversation surgical safety audio recording
effect of opioids on ventilation in children with obstructive sleep apnea

Conditions: Respiratory Depression; Obstructive Sleep Apnea

Summary: the sole objective in this study is to evaluate if routine amounts of opioids given for tonsillectomy in children have greater amounts of respiratory depression in children with documented obstructive sleep apnea when compared with patients that do not have obstructive sleep apnea

ventilatory suppression in children following opioid administration is of obvious concern, especially following routine surgical procedures (i.e. adenotonsillectomy). it is thought that patients with obstructive sleep apnea (osa) have increased sensitivity to opioids, and especially in opioid naïve patients. recent evidence in adults suggests that patients with moderate to severe osa may not predispose patients to increased opioid sensitivity in the form of respiratory depression when compared with patients that do not have osa. it is well known that osa in children is significantly different from osa in adults (e.g. gender predilection, central vs. peripheral causation). the manifestation and etiologies are very different in pediatric osa making it a vastly different disease process.

Eligibility criteria:
inclusion criteria: * tonsillectomy or adenotonsillectomy * ages 2 to 8 years * polysomnography with ahi \>6 (study group) * polysomnography with ahi =0 or negative osa 18 questionnaire (control group) exclusion criteria: * ages \>8 years * patients requiring pre-medication * parental refusal * opioid allergy/intolerance * patients requiring propofol for intubation * patients with known or suspected difficult airway * obesity with body mass index exceeding 30- (control group only) * known cardiovascular disorders * known pulmonary disorders aside from asthma * patients with chronic oxygen requirement * history of prematurity \<35 weeks of gestation * no recent uri * personal of family history of malignant hyperthermia

Keywords: pediatrics opioids obstructive sleep apnea
comparison of the effects of hydromorphone and nalbuphine patient controlled analgesia in postoperative pain after cesarean section

Conditions: Postoperative Pain; Patiet Controlled Analgesia

Summary: cesarean section is an essential surgical procedure in obstetrics, which not only addresses dystocia and certain obstetric syndromes, ensuring the safety of the maternal participants, but also increases perinatal survival rates and can save the mother's life. however, the surgical trauma and uterine contractions resulting from cesarean delivery lead to severe pain, which can hinder the mother's postoperative recovery and negatively affect her mental health. therefore, improving postoperative pain management and addressing issues such as depression and anxiety are crucial challenges in clinical practice today. patient-controlled intravenous analgesia (pca) is widely used in postoperative pain management after cesarean section due to its ability to maintain the minimum effective drug concentration, minimal fluctuation in drug levels, ease of management, and no restriction on activity. however, research on the effects and adverse reactions of hydromorphone and nalbuphine for postoperative pain relief in cesarean section is limited. in this study, the investigators aim to compare the effects of hydromorphone hydrochloride and nalbuphine in obstetric pca and examine how various clinical factors influence pain outcomes and adverse reactions. based on multivariate analysis, the investigators further aim to construct and validate a predictive model for poor analgesic outcomes. to develop more personalized strategies for postoperative pain management following cesarean section, more personalized guidance strategies for postoperative pain management following cesarean section.


Eligibility criteria:
inclusion criteria: * age range from 20 to 50 years old; * asa grades i to iii; * full term pregnancy and planned cesarean section with transverse incision in the lower segment of the uterus; * pregnant women who are willing to participate in this study and sign informed consent forms. exclusion criteria: * have a history of dementia, mental illness, or any central nervous system disorder; * pregnant women who are addicted to alcohol and drugs; * difficulty in follow-up or poor patient compliance; * has taken other investigational drugs or participated in other clinical trials in the three months prior to being selected for the study; * serious complications occur during delivery; * unable to cooperate with the research for any reason.

Keywords: postoperative pain cesarean section surgery hydromorphone nalbuphine predictive model patiet controlled analgesia
randomized controlled trial to assess efficacy of melatonin for children during burn rehabilitation

Conditions: Burns

Summary: the specific aims of this investigation in children during burn rehabilitation include 1.) to determine the efficacy of melatonin intervention on improving sleep-related outcomes 2.) investigate the hypothesis that sleep inadequacy is associated with cognitive deficits and 3.) develop a new methodology specific for burn patients that accurately screens for the presence of intrinsic dyssomnia.


Eligibility criteria:
inclusion criteria: * history of burn injury * scheduled for an elective surgical procedure * 5 - 22 years of age, inclusive exclusion criteria: * history of anoxic brain injury * history of head injury within the last year * pre-existing seizure disorder * pre-existing neurological disorder * pre-existing blindness * known hypersensitivity to melatonin * anticoagulant use or aspirin therapy * antihypertensive medication use * diabetes mellitus or other endocrine disorders * autoimmune disorders * schizophrenia * inability to access internet * intellectual disability or inability to follow directions
controlled intermittent alternate occlusion (ciao) therapy for intermittent exotropia

Conditions: Intermittent Exotropia

Summary: to determine the effectiveness of alternate occlusion therapy for the treatment of ixt among patients aged 3 to \< 11 years old.

intermittent exotropia (ixt) is the most common form of childhood-onset exotropia with an incidence of 32.1 per 100,000 in children. before surgery, many cases of ixt are treated using non-surgical interventions, such as part-time alternate occlusion. however, the "alternating" occlusion with traditional patches is usually out of control. the investigators are uncertain about the amount of "alternating" in patching treatment. here, the investigators introduce controlled intermittent alternating occlusion (ciao) therapy, which is provided by a new electronic device, -liquid crystal glasses. this study is to determine the effectiveness of alternate occlusion therapy for the treatment of ixt among patients aged 3 to \< 11 years old. children with ixt will be randomized into either an observation group or a ciao therapy group.

Eligibility criteria:
inclusion criteria: * intermittent exotropia (manifest deviation) meeting all of the following criteria: * intermittent exotropia at distance or constant exotropia at distance and either intermittent exotropia or exophoria at near * exodeviation at least 15pd at distance or near measured by prism and alternate cover test (pact) * exodeviation at least 10pd at distance measured by pact * no previous surgical or non-surgical treatment for ixt (other than refractive correction) * visual acuity in the worse eye 0.3 logmar or better (20/40 on ats hotv or 70 letters on e-etdrs) for children ≥ 3 years of age * no interocular difference of visual acuity more than 0.2 logmar (2 lines on ats hotv or 10 letters on e-etdrs) for children ≥ 7 years of age * investigator not planning to initiate amblyopia treatment * no hyperopia greater than +3.50 d spherical equivalent in either eye * no myopia greater than -6.00 d spherical equivalent in either eye * no prior strabismus, intraocular, or refractive surgery * no abnormality of the cornea, lens, or central retina * investigator willing to observe the ixt untreated for 3 years unless specific criteria for deterioration are met. exclusion criteria: * n/a

Keywords: ixt
4d-ct for pancreatic adenocarcinoma in radiotherapy simulation

Conditions: Pancreatic Adenocarcinoma

Summary: the primary objective is to study the feasibility and efficacy of individually optimized ce 4d-ct for pda in radiotherapy simulation.

compared with current clinical practice, the individually optimized ce 4d-ct can potentially provide much improved tumor-to-parenchyma conspicuity of pancreatic adenocarcinoma. this will help the radiation oncologists or radiologists to contour the tumor with higher precision and confidence, and compute the tumor volume and tumor motion more accurately.

Eligibility criteria:
inclusion criteria: 1. patients 18 years old or older 2. patients with pda who have not had surgical removal of their tumor and who are planned for treatment with radiotherapy in the radiation oncology department at the university of maryland. 3. patients who have signed the contrast consent form and have been recommended by physicians to have contrast-enhanced ct scans. 4. patients who have signed the consent form for this study exclusion criteria: 1. pregnant or breast-feeding women. 2. patients with severely decreased renal function19-21. 3. patients with known severe allergic reactions to contrast. 4. patients who have difficulty lying flat on their back for extended periods of time. 5. patients with breaths per minute (bpm) rate less than 10, due to the limitation of 4d-ct image reconstruction software.

Keywords: 4d-ct contrast enhanced ct radiotherapy simulation
transcutaneous vagus nerve stimulation for motor recovery after stroke

Conditions: Stroke; Upper Extremity Paresis

Summary: this study will evaluate the safety and effectiveness of respiratory-gated auricular vagal afferent nerve stimulation (ravans) for improving motor recovery after stroke. subacute stroke patients will receive ravans or sham stimulation concurrent with arm motor training during 10 intervention sessions occurring daily for 30 minutes over 2 weeks. the safety and improvements in arm motor function after the intervention will be compared in patients receiving ravans to those receiving sham stimulation.

this study will evaluate the safety, feasibility and effectiveness of respiratory-gated auricular vagal afferent nerve stimulation (ravans) for improving motor recovery after stroke. subacute stroke patients will be randomized to ravans or sham stimulation groups. patients will receive ravans or sham stimulation concurrent with arm motor training during 10 sessions occurring daily for 30 minutes over 2 weeks. safety will be compared in patients receiving ravans to those receiving sham stimulation. feasibility will be evaluated by recruitment into the study and retention of enrolled patients. changes in arm motor function will be compared between ravans and sham stimulation groups from baseline to immediately after the intervention period and to function at 3-months after stroke.

Eligibility criteria:
inclusion criteria: * supratentorial ischemic or hemorrhagic stroke incurred 4-30 days prior; * contralesional ul motor impairment defined by nihss item 5 score 1 or 2 (scale 0-4); * age ≥ 18; * able to provide written informed consent. exclusion criteria: * implanted electronic device (e.g., pacemaker, neurostimulator); * pregnancy; * major psychiatric or medical condition that could interfere with study participation; * medical condition affecting left ear that could interfere with delivering ravans (e.g., wound, infection, malignancy, hypoesthesia); * significant pre-existing disability of stroke-affected ul in activities of daily living due to prior stroke or other medical cause defined by stroke impact scale item 7 (sis-hand) mean score \< 4 (scale: 0-5); * history of seizure during year before stroke or \> 1 post-stroke seizure; * significant cognitive or language impairment that would interfere with informed consent or study participation; * severe dysphagia; * bradycardia defined as resting heart rate \< 50 bpm; * nonsustained ventricular tachycardia; * cardiac conduction disorder (i.e., bundle branch block, heart block, long q-t syndrome); * history of asystole; * history of recurrent vaso-vagal syncope; * hypotension defined as blood pressure \< 90/60 mmhg.

Keywords: stroke vagus nerve stimulation upper extremity paresis
cognitive-behavioral therapy in veterans with schizophrenia

Conditions: Schizophrenia; Schizoaffective Disorder

Summary: this is a study comparing the benefits of two types of individual psychotherapy (cognitive-behavioral therapy for psychosis and supportive therapy) in symptomatic veteran outpatients diagnosed with schizophrenia or schizoaffective disorder. treatment lasted approximately 6 months, with outcome data on symptoms, functioning, and distress levels collected at baseline, post-treatment, and 6 months post -treatment follow-up.

this is a randomized controlled trial comparing 6 months of participation in one of two active treatments, cognitive-behavioral therapy for psychosis or supportive therapy in symptomatic veterans diagnosed with schizophrenia or schizoaffective disorder who are still symptomatic. assessments of clinical status and social functioning were obtained at baseline, end of treatment, and 6 month follow-up. we hypothesized that participation in the cognitive-behavioral therapy would lead to greater reductions in symptoms and distress about symptoms, and more improvements in social functioning.

Eligibility criteria:
inclusion criteria: * outpatients with schizophrenia or schizoaffective disorder in proximity to the west los angeles vamc * at least one month since last hospitalization * stable antipsychotic medication with persisting psychotic symptoms with at least minimal distress * competent to sign informed consent. exclusion criteria: * in other individual psychotherapy * presence of organic brain disease * mental retardation * illness that would prohibit regular attendance in therapy * substance dependence diagnosis in the past 6 months.

Keywords: clinical trials psychotherapy
evaluation of clinical outcomes of chemotherapy or androgen-receptor targeting agent (alone or combined) or radiotherapy on primary tumor in addition to androgen deprivation therapy in hormone-sensitive metastatic prostate cancer patients

Conditions: Prostate Cancer; Hormone Sensitive Prostate Cancer; Metastatic Tumor

Summary: the aim of this observational study is to evaluate the clinical outcomes of treatment with docetaxel, arta (alone or in combination) or with radiotherapy on the primary tumor for mcspc, in an unselected population, in clinical practice


Eligibility criteria:
inclusion criteria: 1. histologically confirmed diagnosis of adenocarcinoma of the prostate, metastatic, not undergoing previous treatment (except hormone therapy initiated no more than 4-6 months prior to docetaxel) for metastatic disease 2. treatment with docetaxel, arpi (alone or in combination) or with radiation therapy on the primary tumor in combination with adt within normal clinical practice or expanded access programs initiated between january 2015 and december 2027. 3. availability of inpatient and/or outpatient medical records for clinical data collection exclusion criteria: 1. histological diagnosis other than adenocarcinoma 2. patients who have received multiple lines of adt for mcspc 3. patients who have received docetaxel or arta for metastatic castration-resistant disease
22g fna needle vs. 22g procore needle

Conditions: Pancreatic Neoplasm

Summary: the aim of this research study is to identify the best needle for performing biopsy during eus procedures. there are two types of needles for performing biopsy: a fna needle that provides a small sample of tissue for analysis and a 22g procore needle that provides larger amount of tissue. it is not clear at this point which of the two needles is superior for performing biopsy. this study will attempt to identify the better needle by assessing the performance of both needles in a randomized fashion.

in this randomized trial, the 22g standard fine needle aspiration needle was compared with the newly developed 22g procore needle for sampling pancreatic mass lesions during endoscopic ultrasound. patients were randomized into the two needle groups and then various outcomes were compared between the two needle types, including the number of passes needed to establish a diagnosis, the ability to procure enough tissue sample to be able to make a diagnosis, the rates of needle failure and complication rates.

Eligibility criteria:
inclusion criteria: -all patients with solid pancreatic mass lesions exclusion criteria: * coaguloapthy, * minors, * prgenant patients

Keywords: passes required to establish diagnosis
a phase 3 prospective, randomized, double-masked, 12-week, parallel group study in pediatric subjects with glaucoma.

Conditions: Glaucoma

Summary: to assess the effectiveness of latanoprost 0.005% ophthalmic solution dosed once-daily and timolol 0.5% dosed twice-daily in paediatric subjects of 18 years of age or under who are diagnosed with glaucoma.


Eligibility criteria:
inclusion criteria: * male or female of 18 years of age or under * diagnosis of glaucoma * iop of 22 mmhg or above in at least 1 eye exclusion criteria: * require surgery for acute angle closure * have had prior cyclodestructive procedures * have a history of ocular trauma or surgery in either eye within 3 months of the baseline visit
prevention trial of nosocomial infections in neutropenic prematures with g-csf

Conditions: Neutropenia in Prematures

Summary: prevention trial of nosocomial infections in neutropenic prematures with g-csf


Eligibility criteria:
inclusion criteria: \< 33 weeks ga neutropenic during at least 24 hours in the first 3 weeks of life and not infected at time of inclusion \< 35 if birth weight \< 1500 g

Keywords: neutropenia prematurity nosocomial infection g-csf
a double-blind placebo controlled study to determine the optimal immunopharmacological dose level of isoprinosine in immunodepressed volunteers

Conditions: HIV Infections

Summary: the objective of this double-blind placebo-controlled study is to evaluate the effect of isoprinosine in a group of homogenous male volunteers who present with immunologic defects relative to: * comparison of total helper and suppressor t-cell number between the groups. * comparison of the phytohemagglutinins (pha) and concanavalin a lymphoproliferative response and natural killer (nk) cell activity between the groups. * determination of the clinical course of the volunteers after discontinuance of isoprinosine.


Eligibility criteria:
exclusion criteria co-existing condition: patients with the following are excluded: * opportunistic infections or kaposi's sarcoma. * critical illness. * history of gout, urolithiasis, nephrolithiasis, renal dysfunction, and severe gastric ulcer. concurrent medication: excluded: * steroids. * cytotoxic immunosuppressive agents. concurrent treatment: excluded: * radiotherapy. the following are excluded: * opportunistic infections or kaposi's sarcoma. * critically ill patients. * patients receiving steroids, cytotoxic immunosuppressive agents, and/or radiotherapy. * patients who have received any other immunotherapy. * patients with a history of gout, urolithiasis, nephrolithiasis, renal dysfunction, and severe gastric ulcer. prior medication: excluded: * any other immunotherapy. patients who fall into the group which is at risk of developing cutaneous sarcoma and/or opportunistic diseases but at present have no signs or symptoms of these diseases.

Keywords: t-lymphocytes, suppressor-effector neoplasms inosine pranobex killer cells t-lymphocytes, helper-inducer acquired immunodeficiency syndrome aids-related complex
maternal polyunsaturated fatty acids in association with child autism spectrum disorder in the marbles study

Conditions: Autism Spectrum Disorder

Summary: this study is to examine the association between maternal omega3 and other polyunsaturated fatty acids (pufas) during pregnancy and autism spectrum disorder (asd) as well as other non-typical development (non-td) in the prospective markers of autism risk in babies-learning early signs (marbles) cohort.


Eligibility criteria:
inclusion criteria: * mother or father had a biological child with asd * mother is at least 18 years old * mother is pregnant or planning a pregnancy, and biologically able to become pregnant * mother is living within 2 hours of the mind institute * mother is sufficiently fluent in english exclusion criteria: * mothers with diseases which will influence on their study participation