Kornimate/medical-research-clean huggingface dataset:
effect of upper extremity aerobic exercise training on exercise capacity patients with chronic heart failure

Conditions: Chronic Heart Failure

Summary: heart failure is a cardiac structural or functional disorder that, despite normal filling pressures, leads to inability to deliver enough oxygen to meet the metabolic needs o tissue. heart failure is a serious chronic condition that affects a large proportion of the adult population in the world causing high mortality, leading to exercise intolerance and reduced health-related quality of life. patients included in the cardiac rehabilitation program slow down disease progression, hospitalization decreases, quality of life improves and health expenditures decrease. despite the frequent use of upper extremities in daily living activities, studies investigating the effect of upper extremity aerobic training on daily living activities, functional exercise capacity and other outcomes are limited. no studies have investigated the effect of upper extremity aerobic exercise training on physical activity level, functional and maximal exercise capacity and other measures in patients with heart failure.

it has been reported that exercise capacity in peak arm exercise is almost 30% lower in heart failure patients. for this reason intolerance to arm exercise is a significant problem in heart failure patients and may contribute to a decrease in performance in activities of daily living. considering the fact that developments in these patients are caused by vasculature functional adaptation the extremity skeletal muscle and applied limbs, upper extremity exercises may be useful to reduce exercise intolerance during activities requiring continuous arm movement.

Eligibility criteria:
inclusion criteria: * patients with a diagnosis of chronic heart failure diagnosed at rest below 40% of the left ventricular ejection fraction and class 1-3 according to the new york heart association classification * optimal medical treatment at least 30 days and clinically stable exclusion criteria: * patients with unstable angina pectoris * decompensated heart failure * primary pulmonary hypertension * complex ventricular arrhythmia * contraindication to cardiopulmonary exercise testing * patients who have had myocardial ischemia in the past 3 months * ischemic cerebrovascular events * second and third degree atrioventricular block * thrombus detected in the left ventricle * uncontrolled insulin dependent diabetes mellitus * uncontrolled hypertension * renal insufficiency * acute infection * aortic stenosis * acute pulmonary embolism * mental, musculoskeletal, neurological, or systemic illness that will prevent exercise.

Keywords: upper extremity aerobic exercise functional exercise capacity maximal exercise capacity respiratory endurance quality of life dyspnea pulmonary function fatigue anxiety depression
a pilot study of an online hiv stigma training for nursing students in iran

Conditions: Stigma, Social; HIV Infections

Summary: in this study, the investigators will assess the feasibility, acceptability, and preliminary efficacy of online hiv stigma training in reducing stigmatizing attitudes and behaviors of nursing students in simulated clinical visits of patients living with hiv compared to an online hiv epidemiology training with no specific content on stigma.

iran has the highest burden of hiv in the middle east. however, only 42% of iranians living with hiv are diagnosed and 28% on antiretroviral therapy. the largest gap in the continuum of hiv care is diagnosis. due to sociocultural and religious beliefs, hiv- associated stigma and drug use stigma are exceedingly high, and sex outside of marriage, or sex of man with another man are considered to be "sinful" behaviors. these intersectional stigmas (stigma towards drug use, sexism, and homophobia) in addition to hiv stigma are major barriers for many people at risk for or living with hiv to engage in hiv testing or treatment. our prior studies found that health providers have limited clinical encounters with people living with hiv (plwh) and have no hiv stigma training. this lack of training can lead to stigmatizing attitudes and behaviors towards people at risk for hiv or plwh. the highest hiv stigmatizing behaviors was reported in nurses and physician assistants. these data, coupled with the extreme marginalization of key populations at high risk for hiv in iran, call for the development of new ways to train nurses to reduce hiv-related stigma in clinical settings. the investigators propose to develop, and field test an hiv stigma online training including simulated patients living with hiv for nursing school students. in a randomized controlled trial, the investigators will assess the feasibility, acceptability, and preliminary efficacy of the online hiv stigma training in reducing stigmatizing attitudes and behaviors of nursing students in simulated clinical visits of patients living with hiv compared to an online hiv epidemiology training with no specific content on stigma. successful development of the hiv stigma training and simulated patients at risk for or living with hiv will set the stage for developing a larger trial of nurses and other health providers which can lead to an effective and scalable training program to reduce hiv-related stigma in clinical settings and improve engagement in hiv testing and care services. the investigators from the university of california san francisco (ucsf), will lead and co-investigate the project, respectively. they will collaborate with teams from kerman university of medical sciences (kmu), iran, and ponce health sciences university (phsu) in the usa.

Eligibility criteria:
inclusion criteria: * currently nursing students in their year 3 or 4 of training * kerman medical university (kmu) nursing schools exclusion criteria: * nursing student in their year 1 and 2 * students of other fields and other universities

Keywords: stigma hiv training iran student nursing
safety and efficacy of non-ablative er:yag laser therapy for the treatment of pelvic organ prolapse and coexisting stress urinary incontinence: a retrospective case series.

Conditions: Cystocele; Pelvic Organ Prolapse; Stress Urinary Incontinence

Summary: the objective of the study is to retrospectively collect the data on patients who underwent pelvic organ prolapse treatment using a non-ablative er:yag laser with smooth mode and to conduct an objective evaluation of safety and efficacy of er:yag laser treatment. in a group of patients that have concomitant stress urinary incontinence symptoms, the effectiveness of the treatments on these symptoms will be evaluated as well.

pelvic organ prolapse (pop) and stress urinary incontinence (sui) affect many women and can dramatically decrease their quality of life. most of the patients diagnosed with stress urinary incontinence also have a degree of pelvic organ prolapse and vice-versa. one of the more promising new approaches in treating disorders connected to pelvic floor dysfunction has been the introduction of vaginal erbium laser treatment for pelvic organ prolapse. the primary aim of the present retrospective study was toassess the effectiveness of vaginal erbium laser with smooth mode for the treatment of patients with pelvic organ prolapse and co-existing stress urinary incontinence, if present.

Eligibility criteria:
inclusion criteria: all patients that had pelvic organ prolapse with or without concomitant stress urinary incontinence and that were treated using non-ablative fotona er:yag laser (prolaplase treatment) in the time period from 2015 to 2016 will be included in this retrospective study. exclusion criteria: patients who failed to attend a follow-up appointment will be excluded from this retrospective case series study.
intensive care unit (icu) diaries as a therapeutic intervention for post traumatic stress disorder (ptsd) following critical illness

Conditions: Post-Traumatic Stress Disorder

Summary: the incidence of ptsd post icu varies from unit to unit, however a significant number of patients have been shown to develop this disorder. many patients do not recall their stay in icu properly and yet can clearly recall nightmares, hallucinations or paranoid delusions, which may be very frightening for the patient to recall at a later stage. as yet, no interventional studies have had an impact on the development of ptsd in this population of patients. however, a recent observational multi-centre study suggested that those patients receiving a diary of their time in icu had lower levels of symptoms of ptsd than those who did not. these results need to be verified in the form of a randomized study.


Eligibility criteria:
inclusion criteria: * patients staying on the icu for at least 72 hours (with greater than 24 hours of artificial ventilation) exclusion criteria: * icu stay \< 72 hours * too confused for informed consent * pre-existing psychotic illness

Keywords: critical illness icu diaries post traumatic stress disorder incidence
the effect of progressive relaxation exercises on sleep quality and fatigue in postmenopausal period

Conditions: Postmenopausal Period; Fatigue; Sleep Quality

Summary: the population of the study will be postmenopausal women who applied to the ketem unit of a hospital in western turkey for examination. this study is a two-group randomized controlled study.

the population of the study will be postmenopausal women who applied to the ketem unit of a hospital in western turkey for examination. this study is a two-group randomized controlled study. these groups will be the experimental group to which progressive relaxation exercises (pge) will be applied and the control group who will continue their routine habits regarding sleep and fatigue problems in the postmenopausal period. minimum number of women to be assigned to groups in the study; determined by power analysis. to our knowledge, a sample size of 90 participants was selected and alpha=0.05 was selected to achieve 80% power to detect the traditionally moderate w=0.30 (moderate effect) differences between study groups, as we know of, according to the literature review. 1988; foul et al, 2007). as a result, it was found that 60 women in total, 30 women in the experimental group and 30 women in the control group, should be included in the study. however, considering the risks such as women leaving the job over time and not being able to reach women, 3 women for each group (10% of the sample) will be included in the study as substitutes and it is anticipated that the research will be completed with a total of 66 women. in order to provide an equal number of samples in the experimental and control groups and to ensure that both groups are similar in terms of all factors, except for the pge application whose effectiveness will be examined, those who experience high levels of fatigue (high scores on the piper fatigue scale) and low sleep quality (pittsburg sleep quality index) randomization will be made between those who score 5 or more on the scales) and those who are similar in terms of independent variables. randomizer.org program will be used to determine the women in the experimental and control groups, by choosing the "random randomization method" in order to provide an equal number of samples in both groups. at the end of the randomization, difference analyzes will be made between the women who will be assigned to the experimental and control groups in terms of sociodemographic, menopausal and pge-related characteristics.

Eligibility criteria:
inclusion criteria: * being in the postmenopausal period, * agreeing to participate in the research, * being able to read and write, * those experiencing high levels of fatigue * women with poor sleep quality exclusion criteria: * experiencing menopause due to surgery, pharmacological reasons, * not being willing to participate in the study, * presence of any communication problems, * being in premenopause and perimenopause period.

Keywords: postmenopausal period fatigue sleep quality progressive relaxation exercise
an evaluation of a dynamic web-based visualization of community immunity

Conditions: Vaccine-Preventable Diseases

Summary: this study is a phd project conducted by ms. hina hakim, supervised by dr. holly o. witteman, phd, and co-supervised dr. daniel reinharz, professors and researchers at the faculty of medicine at laval university. the purpose of this study is to evaluate the effects of visualization conveying the concept of community immunity or herd immunity on risk perception (towards individual, family, community and vulnerable people in communities) (primary outcome) and on emotions, attitudes, knowledge, and behavioural intentions (secondary outcomes).

visualization is a powerful communication mechanism that uses pre-attentive processing to communicate large amounts of information rapidly in understandable and compelling ways (healey and enns 2012). a systematic review demonstrates that there are some interventions available for conveying the concept of community immunity, and very few evaluate interventions for their effects on vaccine intentions and uptake as well as their precursors, such as knowledge, attitudes, knowledge and none on emotions (hakim et al. 2018). the purpose of this study is to evaluate the effects of visualization conveying the concept of community immunity on risk perception (to individual, family, community and vulnerable people in communities) (primary outcome) and on emotions, attitudes, knowledge, and behavioural intentions (secondary outcomes).

Eligibility criteria:
inclusion criteria: * members of the general population in canada * at least 18 years old * able to provide free and informed consent * able to read and understand french or english * able to use a computer exclusion criteria: - no internet access

Keywords: herd immunity community immunity web-based application visualization
virtual reality for burn wound care pain control

Conditions: Pain; Anxiety

Summary: the investigators propose to study the effects of virtual reality (vr) on patients' pain perception during burn wound care. such variables include psychiatric diagnosis and standard pain coping (i.e. pain catastophizer vs. non-pain catastrophizer).aims: the investigators intend to evaluate the use of virtual reality in pain distraction for burn patients undergoing burn wound care. to that end our aims are: 1) to determine if pain perception will be less during the portion of the procedure in which the patient is immersed in the vr session in comparison to the portion of wound care which will occur without vr immersion. 2) to determine if anticipatory anxiety will be less for the portion of wound care that includes the virtual reality in comparison to the portion without virtual reality. 3) to determine if current psychiatric diagnosis, especially acute stress disorder and depression, is related to higher pain perception and greater decrease in pain with the virtual reality distraction. 4) to determine if being a "pain catastrophizer" is related to higher pain perception and greater benefits from the


Eligibility criteria:
inclusion criteria: * age 12-100years * minimum burn wound size of 2% total body surface area (tbsa) excluding head and dominant hand * be able to sit upright independently in bed * minimum pain rating of 4/10 on a visual analog scale (only using the most painful extremity). * able to consent to the study exclusion criteria: * known history of motion sickness * seizures * migraines * current psychosis, dementia, or delirium * current blindness and/or deafness that significantly affects their ability to experience the vr

Keywords: burn pain anxiety
olanzapine 2.5 vs 5 mg in quadruplet nausea/vomiting prophylaxis before high-dose melphalan

Conditions: Multiple Myeloma; Autologous Stem Cell Transplantation

Summary: patients who receive a chemotherapy called melphalan are at high risk of having nausea and vomiting. a medication called olanzapine has been shown to decrease nausea and vomiting after chemotherapy. a previous research study found the 10 mg dose of olanzapine (combined with 3 standard medications used routinely to prevent nausea/vomiting) to be effective for patients who received melphalan chemotherapy, but several other studies have shown many patients have a side effect of sleepiness (e.g., sedation) with that dose of the medication. our study will compare two lower doses of olanzapine (5 mg and 2.5 mg) in combination with the 3 standard medications used to prevent nausea/vomiting in the patients who receive melphalan chemotherapy to determine which dose is effective in preventing nausea and vomiting with the lowest amount of sleepiness side effect.

this study is a randomized, double-blinded trial comparing olanzapine 2.5 mg vs 5 mg in combination with standard triplet antiemetic prophylaxis in patients with multiple myeloma who are receiving high-dose melphalan conditioning chemotherapy before autologous stem cell transplantation to determine chemotherapy-induced nausea and vomiting (cinv) and sedation outcomes.

Eligibility criteria:
inclusion criteria: * receipt of high-dose melphalan 140-200 mg/m2 * autologous stem cell transplantation recipient exclusion criteria: * allergy to olanzapine * documented nausea or vomiting within 24 hours prior to enrollment * treatment with other antipsychotic agents such as risperidone, quetiapine, clozapine, phenothiazine, or butyrophenone within 30 days prior to enrollment or planned during protocol therapy * chronic alcoholism * pregnant * decline or unable to provide informed consent

Keywords: cinv nausea olanzapine melphalan autologous transplant
effect of inhalation sedation compared with propofol on the sepsis-related acute respiratory distress syndrome course

Conditions: ARDS

Summary: investigation of effect of inhalation sedation by administration of sevoflurane compared with propofol on the moderate acute respiratory distress syndrome course in mechanically ventilated patients with sepsis.


Eligibility criteria:
inclusion criteria: * sepsis * ards * p/f ratio 100-250 * start of mechanical ventilation exclusion criteria: * pregnancy * concomitant oncological disease * prior psychological impairment

Keywords: sedation ards sepsis outcome
predicting and preventing adverse maternal and child outcomes of opioid use disorder in pregnancy

Conditions: Opioid Use Disorder; Pregnancy Related

Summary: this study will be a 12-month prospective, genotype-blinded longitudinal observational study with current standard of clinical care. this study will enroll 100 pregnant women with oud at upmc hospitals with its high volumes. because of the observational nature of the study, the anticipated dropout rate will be ≤ 20%. investigators expect the effective sample size of evaluable patients will be 200 with longitudinal data.

background: 7% of pregnant women in the u.s. use opioids and 21% of these women report misuse, making opioid use disorder (oud) a major public health concern during pregnancy. the number of infants born with prenatal opioid exposure, neonatal opioid withdrawal syndrome (nows) and costly prolonged hospitalization has increased exponentially. the opioid epidemic is further worsened by the ongoing covid-19 pandemic. despite medication treatment for oud with buprenorphine (bup) or methadone (meth), these pregnant women continue to be at high risk for early relapse, polysubstance use, and depression. these infants are at risk for not only immediate nows and also poor long-term neurodevelopmental and behavioral outcomes. genetic factors influence 30-60% of opioid adverse events (aes). in pregnant women on medication management for oud, and infants receiving opioids for nows treatment there is variability in dose required to prevent withdrawal symptoms and craving, likely related to physiological alterations, upregulation of metabolic and biological pathways, determined in part by opioid pharmacogenomics. investigators have shown that in children and adults, opioid related poor clinical outcomes are related to opioid receptor genetic variations and resulting variations in their metabolism. maternal depression and anxiety increase the risks for oud, maternal relapse, nows and negatively impact pregnant women and their children. thus, there is an urgent and unmet clinical need for a reliable tool to proactively predict maternal relapse, nows, and improve the safety of pregnant women with oud and their children.

Eligibility criteria:
inclusion criteria: * pregnant women with oud and their infant * currently on bup/meth for oud * enrolled in prenatal opioid maintenance program * age \>18 years * singleton pregnancy * planned delivery at upmc's magee womans hospital * positive opioid urine screen results exclusion criteria: * serious maternal medical illness as deemed by the pi that would make it challenging to comply with study procedures * hiv or aids * known major fetal congenital abnormalities
outcome of autosomal dominant polycystic kidney disease patients on peritoneal dialysis: a national retrospective study based on two french registries (the french language peritoneal dialysis registry and the french renal epidemiology and information network).

Conditions: Polycystic Kidney Diseases

Summary: pathological features of autosomal dominant polycystic kidney disease (adpkd) include enlarged kidney volume, a higher frequency of digestive diverticulitis and abdominal wall hernias. therefore, many nephrologists have concerns about the use of peritoneal dialysis (pd) in adpkd patients. we aimed to analyze survival and technique failure in adpkd patients treated with pd.

pathological features of autosomal dominant polycystic kidney disease (adpkd) include enlarged kidney volume, a higher frequency of digestive diverticulitis and abdominal wall hernias. therefore, many nephrologists have concerns about the use of peritoneal dialysis (pd) in adpkd patients. we aimed to analyze survival and technique failure in adpkd patients treated with pd. we conducted two retrospective studies on patients starting dialysis between 2000 and 2010, and based on two french registries: the french renal epidemiology and information network (rein) and the french language peritoneal dialysis registry (rdplf).

Eligibility criteria:
iinclusion criteria : * patients starting dialysis * patients included from the french renal epidemiology and information network (rein) and the french language peritoneal dialysis registry (rdplf) exclusion criteria * patients without diagnosis of nephropathy
post kidney transplant nocturnal hypertension prevalence and management study

Conditions: Hypertension

Summary: hypertension (htn) affects up to 75% of kidney transplant recipients and is associated with premature death. nocturnal htn is a common complication of ongoing essential htn or a secondary cause of htn. both the non dipping of systolic blood pressure (sbp) at night time and the reverse dipping is associated with increased target organ damage and adverse cardiovascular outcomes and possibly allograft survival. treatment of nocturnal htn is critical. chronotherapy has been shown to be effective in halting progression in patients with diabetic nephropathy and chronic kidney disease. there is not enough data on prevalence and management of nocturnal htn in transplant patients, which is the object of this study.


Eligibility criteria:
inclusion criteria: 1. renal transplant more than 1 year ago and not on dialysis. 2. age between 18 years to 70 years. 3. known history of htn on one or more anti-hypertensive medication. 4. stable anti-hypertensive regimen for past 2 months 5. one of the anti-hypertensive regimen must include an ace inhibitor, or an angiotensin receptor blocker, calcium channel blocker, alpha or beta blocker. 6. stable immunosuppressive regimen with no dose changes in past 3 months. 7. no hospitalizations for previous 2 months exclusion criteria: 1. inability to consent 2. history of falls 3. presence of avf or avg in both the arms 4. inability to follow up in renal transplant clinic. 5. history of atrial fibrillation. 6. pregnant women 7. parkinson's disease 8. severe orthostatic hypotension 9. severe autonomic dysfunction 10. history of other transplanted organs

Keywords: nocturnal hypertension nondipping renal transplant chronotherapy