Kornimate/medical-research-clean huggingface dataset:
integrative cognitive-affective therapy for adolescent eating disorders

Conditions: Eating Disorder; Emotional Disorder

Summary: recently, integrative cognitive-affective therapy (icat), a novel intervention for bulimia nervosa (bn) and binge eating disorder (bed) that targets emotion regulation deficits, has shown promise in reducing eating disorder symptoms as well as improving emotion regulation capacities in adults. however, this treatment has not been investigated in an adolescent sample. given the contributing role of emotion regulation in adolescent eating disorder symptoms and limited treatment options for adolescents with bn and bed, the aim of this study is to adapt the existing adult icat treatment for adolescents with clinically significant binge eating (icat-a) and to evaluate the extent to which icat-a is helpful in reducing binge eating and associated eating disorder symptoms in a younger sample.


Eligibility criteria:
inclusion criteria: * subject with full and sub-threshold bulimia nervosa and binge eating disorder (that is binge eating weekly) * no major weight loss (defined as a reduction of 10% baseline body weight or more) * subject who meet criteria for any diagnostic and statistical manual of mental disorders (dsm-5) eating disorder characterized by binge eating with or without compensatory behavior * subjects who take medications that do not directly impact weight or appetite (including selective serotonin reuptake inhibitors (ssri) antidepressants) will be included if their dose has been stable for at least six weeks * subject must be living at home * at least one parent/guardian is willing to participate in the treatment. exclusion criteria: * subject on medications that influence weight or appetite (including antipsychotic medications) * subject who is medically or psychiatrically unstable (defined as requiring hospitalization within the past 3 months) * acutely suicidal requiring current hospitalization or who meet criteria for substance use disorder in the past month * subjects who become or psychiatrically unstable during the study will be re-evaluated, removed from the study, and referred for appropriate treatment.
prediction of functional health status and aspiration using multiple dysphagia scales over 6 months after acute stroke

Conditions: Acute Stroke; Dysphagia

Summary: in order to discover dysphagia scales, which shows meaningful predictability of aspiration and functional health status in patients with acute stroke, authors plan to find out more predictable indicators than existing penetration-aspiration scale (pas) to validate their predictions and their internal and external validity over 6 months following stroke .

to determine the dysphagia scale with significant predictions of aspiration and functional health status in patients with acute stroke, video-fluoroscopic swallowing study (vfss) will be performed to the patients who will be referred for vfss among stroke patients who would be diagnosed by brain mri / ct. when any type of dysphagia is found, participant will be assigned to the test group (dys), and when no dysphagia is found, they will be assigned to the control group (nod). numerous kinds of assessment will be conducted before and after vfss, before discharge, and 3, 6, and 9 months after the stroke onset.

Eligibility criteria:
inclusion criteria: * brain mri / ct-based stroke patients who were referred for vfss exclusion criteria: * in case of a history of dysphagia * unstable patient in neurology * 2 or higher of nihss 1a (level of consciousness) * patients with other neurological diseases * patients with decompression skull resection * refusal of participation
effectiveness of global postural reeducation in patients with chronic symptomatic lumbar disc herniation

Conditions: Lumbar Disc Herniation.

Summary: slipped disc is the rupture of the fibrous ring, with subsequent displacement of the nucleus pulposus in intervertebral spaces, which may cause compression of nerve structures. it is estimated that 2-3% of the population have taken with this process, whose prevalence is 4.8% in men and 2.5% in women over 35 years. thus, the purpose of this study is to verify the effectiveness of global postural reeducation in patients diagnosed with chronic symptomatic lumbar disc herniation with the application of a randomized controlled trial. will be measured pain, disability and functional flexibility.


Eligibility criteria:
inclusion criteria: patients diagnosed with chronic symptomatic lumbar disc herniation exclusion criteria: patients who work with severe overloading of the spine, patients with central neurological pathology, wheelchair users, patients who use bracing and support those who submit two consecutive absences to the treatment
a retrospective cohort study on predicting delayed graft function in liver transplant patients with hepatocellular carcinoma: a nomogram and machine learning approaches.

Conditions: Hepatocellular Carcinoma (HCC); DGF

Summary: background: this study aimed to develop a predictive model for delayed graft function (dgf) in liver transplant patients with hepatocellular carcinoma (hcc) based on preoperative biochemical indicators, using both logistic regression and xgboost machine learning algorithms. methods: a retrospective cohort study was conducted, including 131 liver transplant patients from january 2020 to april 2022. preoperative biochemical markers and hematological parameters were analyzed. logistic regression and xgboost models were constructed to predict dgf, and their performance was evaluated using the area under the roc curve (auc). shapley additive explanations (shap) analysis was employed to interpret the feature contributions.


Eligibility criteria:
inclusion criteria: 1. patients with liver cancer aged between 18 and 75 years. 2. patients who have received liver transplantation. 3. complete preoperative and postoperative medical imaging data, clinical records and pathological test reports are available. exclusion criteria: 1. primary non-hepatocellular carcinoma 2. recipients were younger than 18 years and older than 75 years 3. due to incomplete or missing clinical data, this dataset did not meet the criteria for inclusion in the statistical analysis. 4. serious complications associated with liver transplantation, such as acute transplant rejection or transplant liver failure, occur within 7 days after surgery. 5. re-surgery within 7 days after surgery due to liver transplant-related complications or other surgical procedures, such as transplant site infection or other major surgery.
body composition in preschool children

Conditions: Obesity; Wasting

Summary: thailand has been facing with the double burden of malnutrition. many studies in thailand, which aim to explore the situation, causes, and strategies to prevent obesity, have focused on adults, adolescents, or school-aged children. few studies have been conducted in preschool children. obesity or stunting during childhood increases the risk of being obesity in adulthood and leads to chronic diseases. if obesity is established in adulthood, it is difficult to reduce the excess weight. thus, the prevention of obesity or stunting in young children should be highly considered. study of dietary pattern and reliable field methods to measure fat mass (fm) in children may partly contribute to primary prevention of childhood obesity. the deuterium dilution technique is an accurate and suitable method for children and population-based studies. however, it has not been widely used in children in thailand. hence, this study aimed to utilize the deuterium dilution technique for assessing body composition and to determine the quality and quantity of dietary intake among children 3-5 years of age with different nutritional status. we conducted a cross-sectional study in 15 daycare centers in nakhon pathom and samut prakarn provinces. 120 preschoolers were purposively selected according to their nutritional status: stunted, thin, normal, and overweight/obese. anthropometric measurements were conducted. body composition was determined based on total body water using deuterium dilution technique. dietary intake data were obtained using 2-day 24 hr recall.we hypothesized that stunted and obese children will have more fat mass compared to the normal children.

body composition of the children was assessed using the deuterium technique. total body water (tbw) content was calculated. then, fat free mass (ffm) and fat mass (fm) was calculated. weight and height of all children were using a standard technique. body mass index and nutritional status was calculated using world health organization (who) growth standard for children 0-5 years. dietary intake of children was assessed using 2 non-consecutive 24 hour dietary recalls. the 1st and 2nd recall was about 2 weeks apart. nutrient intake was calculated using the inmucal-nutrients wd. 4.0 (institute of nutrition, 2010).

Eligibility criteria:
inclusion criteria: * healthy children * aged 3-5 years * bmi or haz fall in the study protocol exclusion criteria: * chronic diseases * ongoing medical treatments likely to affect body composition * malformation or muscle diseases

Keywords: preschool children body composition
evaluation of myostrain™ in clinical practice

Conditions: Cardiac Failure; Coronary Artery Disease; Sarcoidosis; Amyloidosis; Lupus; Myocarditis; Drug Toxicity

Summary: evaluate myostrain cardiac mri pulse sequence in clinical practice

evaluate myostrain cardiac mri pulse sequence in clinical practice to determine how the use may alter treatment decisions and clinical outcomes in patients who are undergoing cardiac mri.

Eligibility criteria:
inclusion criteria: * patients already scheduled for diagnostic testing with commercially available imaging modality (cardiac mri) * the patient population will include (but not limited to), those being evaluated for heart disease and heart failure that may be related to vascular disease (coronary artery disease), drug related heart failure (chemotherapy, alcohol), inflammatory systemic conditions (sarcoidosis, amyloidosis, lupus), myocarditis, and/or infectious etiologies * provided written informed consent exclusion criteria: * contraindication to magnetic resonance imaging

Keywords: mri senc myostrain
urinary biomarkers as predictors on renal function in congenital hydronephrosis

Conditions: Ureteral Obstruction

Summary: the purpose of this study is to detect new urinary biomarkers that can be used as predictors on renal function in congenital hydronephrosis caused by unilateral ureteral obstruction (uuo) and to elucidate the pathophysiology of uuo.


Eligibility criteria:
inclusion criteria: * children referred to surgical treatment of congenital hydronephrosis caused by ureteral obstruction. * declining function of the hydronephrotic kidney more than 5 %, and to less than 40 % of the total renal function or ipsilateral flank pain. exclusion criteria: * bilateral hydronephrosis * previous operation in the urinary system except operation for phimosis and other deformations of the external genital organs. * deformations in the lower part of the ureter, bladder and urethra. urinary stones. reflux. urinary tract infections \< 6 months. * neurogenic bladder dysfunction. * gfr \< 40 % standardized to age. * non-compliance. linguistic difficulties.

Keywords: hydronephrosis ureteral obstruction
internet-based self-help after spousal bereavement or divorce

Conditions: Prolonged Grief Symptoms

Summary: the purpose of this study is to evaluate the efficacy of an internet-based self-help intervention for older adults with prolonged grief symptoms after spousal bereavement or separation/divorce. the study design is a randomized trial with a waiting control condition of 12 weeks and a follow-up after 6 months. the investigators will test the following main hypotheses: 1. the intervention group shows a significant decrease in grief symptoms, psychological distress, depression symptoms and embitterment, and a significant increase in life satisfaction, as well as session related outcomes from baseline to 12 weeks post intervention assessment. 2. the effects in the intervention group are larger than the effects in the waiting control group. 3. these effects are stable from the post measure at 12 weeks to the 6-month follow-up.


Eligibility criteria:
inclusion criteria: * marital bereavement or separation/divorce. both events should have happened more than 6 months before participating in the study. * seeking support for coping with grief symptoms * internet access * mastery of the german language * informed consent exclusion criteria: * acute suicidality (bdi suicide item \> 1 or suicidal ideation in the telephone interview) * no emergency plan: in the telephone interview, an emergency plan will be developed which specifies a health care professional, who participants can turn to in an acute crisis. if no such person or health care service can be found, individuals will be excluded from the intervention. * severe psychological or somatic disorders which need immediate treatment. * concomitant psychotherapy (participants may take part in the self-help intervention, but will not be included in the study.) * prescribed drugs against depression or anxiety lead to an exclusion if prescription or dosage has changed in the month prior or during the self-help intervention. * inability to follow the procedures of the study, e.g. due to comprehension problems

Keywords: grief depression bereavement divorce online self-help
study of the safety and efficacy of desvenlafaxine succinate for vasomotor symptoms in postmenopausal women

Conditions: Menopause; Vasomotor System

Summary: the purpose of this study is to evaluate the efficacy and safety of 100 mg and 150 mg of dvs sr, an extended release form of desvenlafaxine succinate, in comparison to placebo for the treatment of vasomotor symptoms (vms) associated with menopause in a population of postmenopausal women.

to assess the efficacy and safety of 100 mg and 150 mg of dvs sr in comparison to placebo for the treatment of moderate to severe vms associated with menopause, as well as additional outcome indicators such as sleep disruptions, overall climacteric symptoms, mood changes, somatic symptoms, and overall satisfaction with dvs sr in postmenopausal women.

Eligibility criteria:
inclusion criteria: * generally healthy, postmenopausal women who seek treatment for hot flushes * body mass index (bmi) less than or equal to 40 kg/m2 other inclusions apply. exclusion criteria: * hypersensitivity to venlafaxine * myocardial infarction and/or unstable angina within 6 months of screening * history of seizure disorder other exclusions apply.
endoscopic evaluation of upper gastrointestinal (gi) mucosal damage induced by pl-2200 versus aspirin in healthy volunteers

Conditions: Upper Gastrointestinal Mucosal Damage

Summary: to determine the gastrointestinal safety of pl-2200 versus immediate-release aspirin by assessing endoscopic gastroduodenal mucosal injury at approved daily cardiac-protective doses of aspirin (325 mg) in normal healthy volunteers.


Eligibility criteria:
inclusion criteria: * subject is ≥50 to ≤75 years of age. * subject is healthy. * subject has a bmi between 20 and 32 * if female and of child bearing potential, subject has a negative pregnancy test and is not nursing. exclusion criteria: * subject has abnormal screening/baseline laboratory parameters or endoscopic observations deemed clinically significant by the investigator. * subject has an active helicobacter pylori infection. * subject has a prior gi ulcer, bleeding, obstruction or perforation. * subject has taken aspirin or any aspirin containing product within the last 4 weeks, or a non-aspirin nsaid product within 2 weeks. * subject has taken any of the following medications within 2 weeks prior to enrollment: any anti-platelet agents, anti-coagulants or selective serotonin reuptake inhibitors. * subject has used an investigational agent within the past 30 days. * subject has hypersensitivity or contraindications to aspirin, ibuprofen, or other nsaid.

Keywords: to evaluate the acute gastrointestinal safety of pl-2100.
nicotine differences in smokers

Conditions: Nicotine Dependence

Summary: the primary aim of this project is to determine the threshold dose of nicotine, which the smokers will be able to differentiate from placebo (saline). will use iv pulsed-nicotine infusion that closely matches nicotine delivery by inhaled tobacco use (i.e., tobacco cigarette or electronic cigarette), allowing precise and reproducible nicotine delivery. four nicotine doses (0.1, 0.05, 0.025, and 0.0125 mg nicotine/pulse) which are within the range of nicotine doses that are delivered by cigarettes with very low to regular nicotine content. these doses will be delivered as a cluster of 4 pulsed-nicotine infusions of 2 sec duration with a 28 sec interval between each dose.

twenty participants will have 2 experimental session on 2 separate days. experimental session 1 will determine if smokers can reliably discriminate 0.1mg nicotine/pulse nicotine from saline. experimental session 2 will determine if smokers can discriminate 0.05, 0.025, and 0.0125 mg nicotine/pulse of nicotine from saline. hypothesis: the threshold for discrimination will be 0.05 mg nicotine/pulse and the doses below that (0.025, and 0.0125 mg nicotine/pulse) will be subthreshold. exploratory aim: to explore the relationship between the threshold for subjective drug effects and drug discrimination.

Eligibility criteria:
inclusion criteria: * female and male smokers, aged 18 to 65 years veterans and non-veterans who have been smoking tobacco cigarettes for at least a year * smoke ≥ 5 cigs/day ; * urine cotinine levels \> 100 ng/ml consistent with nicotine intake of an active smoker (23) * not seeking treatment at the time of the study for nicotine dependence * good health as verified by medical history, screening examination, and screening laboratory tests * for women, not pregnant as determined by pregnancy screening, nor breast feeding, and using acceptable birth control methods. exclusion criteria: * history of major medical or psychiatric disorders that the physician investigator deems as contraindicated for the subject to be in the study * regular use of psychotropic medication (antidepressants, antipsychotics, or anxiolytics) * current alcohol or substance dependence for any other recreational or prescription drugs other than nicotine * use of e-cigarettes more than 10 days in the past 30 days * urine drug screening indicating recent illicit drugs use (with the exception of marijuana).
iv or iv/po omadacycline vs. iv/po levofloxacin for the treatment of acute pyelonephritis

Conditions: Acute Pyelonephritis

Summary: the purpose of this study was to evaluate the safety and efficacy of intravenous (iv) or iv/per oral (po) omadacycline as compared to iv or iv/po levofloxacin in the treatment of female adults with acute pyelonephritis.

this was a randomized (1:1:1:1:1), double-blind, double-dummy, adaptive designed, phase 2 study. based on review of the efficacy and microbiology data, the dmc modified the randomization algorithm, and no further participants were enrolled in the following treatment arms after may 2019: the omadacycline 200 iv/100 iv, omadacycline 200 iv/300 po or 100 iv, and omadacycline 200 iv/450 po or 100 iv arms. after this change, participants were randomized in a 1:1 ratio to either the omadacycline 200 iv/200 iv or levofloxacin arms.

Eligibility criteria:
inclusion criteria: * female participants, age 18-65 years who have signed the informed consent form * must have a qualifying acute pyelonephritis * participants must not be pregnant at the time of enrollment * must agree to a reliable method of birth control during the study and for 30 days following the last dose of study drug * must be able to comply with all of the requirements of the study exclusion criteria: * males * symptoms of acute pyelonephritis present for longer 7 days prior to randomization * infections that require antibacterial treatment for greater than 14 days * evidence of suspected non-renal source of infections, vaginitis, or sexually transmitted infection * evidence of significant immunological disease * evidence of liver impairment or disease * evidence of unstable cardiac disease * severe renal disease or requirement for dialysis * evidence of septic shock * has a history of hypersensitivity or allergic reaction to any tetracycline or to levofloxacin * has received an investigational drug within the past 30 days * participants who are pregnant or nursing * unable or unwilling to comply with the protocol requirements
relationship between alzheimer disease and diminution of the three macular nervous retinal layers

Conditions: Optical Coherence Tomography; Optical Coherence Tomography Angiography; Retinal Thickening; Alzheimer Disease; Lewy Body Disease; Retina; Cortical Atrophy; Retinal Nerve Fibres Layer

Summary: alzheimer disease is hard, long and expensive to diagnose. in order to help the clinician, a new biomarker in alzheimer disease seems to be very useful. the retina, as a window of the brain, could offer a new way to diagnose this common disease. indeed, a retinal atrophy could especially appear in alzheimer disease. besides, many aspects about retinal alteration, visual function and their link with the disease deserve to be more explored. so as to fill these gaps, a new study about retinal specificity in alzheimer disease appears to be relevant.


Eligibility criteria:
inclusion criteria: * patients having a consultation in the research and resources memory center of amiens (rrmc) , * patients registered in the alzheimer national bank and having an alzheimer disease based on nia-aa (mckahnn2011)and iwg2 (dubois et al, 2014) criteria or, having a lewy body disease based on revised criteria of mckeith et al 2020 * patients having a complete neuropsychological evaluation including a visual inspection time. * patients having a mmse ≥ 18/30 so as to ensure a good homogeneity of the group and to have an adequate ocular exam's quality. * patients having an available mri in the chu's database including a 3dt1 sequence * patients having a visual acuity better than 5/10, spherical refraction of +/- 5d, an astigmatism \< 3d and an applanation iop \<22mmhg exclusion criteria: * any other neurocognitive disorder * any other optical neuropathy including glaucoma * all kind of retinal disease (diabetic retinopathy, age-related macular degeneration...) * diabetes mellitus * uncontrolled hypertension blood pressure * any ophthalmological conditions interfering with a good ocular examination or oct quality (cataract, corneal opacity..) * severe dementia preventing a good ophthalmological examination * not consenting patient * patient with guardianship or curatorship having symptoms preventing a good ophthalmological examination (agitation, unstable ocular fixation)

Keywords: optical coherence tomography optical coherence tomography angiography retinal thickening alzheimer disease lewy body disease retina cortical atrophy retinal nerve fibres layer cell ganglion layer intern plexiform layer