Kornimate/medical-research-clean huggingface dataset:
set your goal: engaging go/no-go active learning

Conditions: Depression; Anxiety

Summary: this study will test a computational model reinforcement learning in depression and anxiety and test the extent to which the computational model predicts response to an adapted version of behavioral activation psychotherapy. the model will be based on a data from a computer task of reinforcement learning during 3t functional magnetic resonance imaging at baseline.

the dysfunction of reinforcement learning is emerging as a transdiagnostic dimension of mood and anxiety. computational models of reinforcement learning may expedite our ability to identify predictors of response, thereby improving efficacy rates. we will will, first, examine the neural substrates of reinforcement learning in depression and anxiety, and, second, test a computational model of reinforcement learning as a predictor of response to an adapted version of behavioral activation psychotherapy. subjects (n=10) will be enrolled in a two week evaluation, followed with a nine week weekly intervention program. assessments will be conducted at baseline, and during the intervention as the 3-, 6-, 9-week follow-ups. reinforcement learning will be measured using 3t magnetic resonance imaging during a computer task. all other measures include structured clinical interviews, questionnaires, and computer tasks.

Eligibility criteria:
inclusion criteria: * between the ages of 21 and 40 * physically healthy * right handed * normal or corrected to normal vision * scores equal or higher of (a) 24 on inventory of depressive symptomatology, self report, or (b) 15 on the generalized anxiety disorder self report. exclusion criteria: * not currently in therapy or taking medications for anxiety or depression * no contraindications for the magnetic resonance scan (claustrophobic) * no history of head trauma, seizures, loss of consciousness * not taking hormone replacement, not pregnant * no imminent suicidality * no report of excessive alcohol or drug use in past three months

Keywords: reinforcement learning computational models neuroimaging
trifecta achievement in open and laparoscopic partial nephrectomy

Conditions: Trifecta Achievement; Pentafecta Achievement

Summary: background: partial nephrectomy (pn) is a reference standard for the management of the ct1 renal mass, primarily due to better preservation of renal function. the aim of this work was to determine trifecta outcomes of open pn (opn) and laparoscopic pn (lpn) and identify predictive factors for trifecta achievement to evaluate surgical performance, including negative surgical margins, absence of severe surgical complications, and ischemia time less than 25 minutes. objectives: this study pointing to determine trifecta outcomes of opn and lpn and to identify predictive factors for trifecta achievement to evaluate surgical performance, including negative surgical margins, absence of severe surgical complications, and ischemia time less than 25 minutes.

methods: this prospective, randomized study was carried out on 35 patients with clinical t1 n0m0 renal tumors. patients were divided into two groups: group a (n=38): underwent opn and group b (n=32): underwent lpn.

Eligibility criteria:
inclusion criteria: * • patients who are fit for surgery. * patients with renal tumor who are indicated for partial nephrectomy absolute: 1. solitary kidney. 2. bilateral renal tumor. 3. cdk. relative: 1. abnormal contralateral kidney (nephropathy, nephrolithiasis, trauma). 2. metabolic disease associated with renal failure (dm, hypertension). 3. genetic syndrome with tumor multifocality (vhl syndrome). elective 1. clinical t1n0m0 tumor. 2. peripheral tumor. exclusion criteria: * • patients who are unfit for surgery and who's unfit for laparoscopy. * patients who are contraindicated for partial nephrectomy. as severe and irreversible coagulopathy. patients who are indicated for radical nephrectomy (extensive tumor, metastatic tumor).

Keywords: laparoscopic, partial nephrectomy trifecta, pentafecta achievement renal tumors
infants with down syndrome on a different surface

Conditions: Down Syndrome

Summary: this study included infants with down syndrome who applied to the faculty of physical therapy and rehabilitation, developmental and early physiotherapy unit of hacettepe university. the project is characterized to investigate whether there is any differences on different surface between infants with down syndrome and typically infants who are in the same conditions.

down syndrome is the most common chromosomal abnormality among the new-borns and characterized by the cognitive deficits, hypotonia, motor developmental and sensory function problems. the somatosensory system disorder such as touch, proprioception, pain and temperature may be seen in these infants and children. there is a delayed peripheral conduction of the stimulus and delayed cerebral processing may cause the abnormal tactile perception response. in the earliest period of life general movements (gms), a gestalt-based observation method is one of the most reliable and valid predictors of neurological dysfunction, and it is widely used. gms occur in age-specific patterns and are described as fidgety movements between from 3 to 5 months in the post-term age. we did the gms assessment on two different surfaces in the infants with ds and typically infants on the same day, and therefore assumed that determining the fidgety movements and the concurrent movement would enable to us observe the effect of extroceptive stimulation on the fidgety movements and the concurrent movement. the aim of this study was to investigate the following questions: (i) are fidgety movements and the concurrent motor repertoire of infants with ds depending on different surfaces?, (ii) do fidgety movements and the concurrent motor repertoire change in neurotypical infants depending on the different surface?, and (iii), what are the differences between infants with ds and neurotypical infants?.

Eligibility criteria:
inclusion criteria: * infants aged between 3 and 5 months in both groups * infants without any neurological, genetic or metabolic disorder diagnosis in the control group exclusion criteria: * infants whose parents did not want to participate study.

Keywords: down syndrome different surface fidgety movements general movements
effectiveness of eca cream on calcifying shoulder tendinitis

Conditions: Calcifying Shoulder Tendinitis

Summary: this pilot trail aims to assess the effectiveness of eca cream in the treatment of calcifying shoulder tendinitis in terms of: 1. reduction or removal of shoulder calcifications 2. functional improvements 3. pain improvements 10 subjects will be assessed prior and 1 and 2 months post intervention onset. the intervention will consist in the application of the eca cream in the affected shoulder twice a day during 1 month.


Eligibility criteria:
inclusion criteria: * patients \>=18 years * diagnosed of calcifying shoulder tendinitis diagnosed by a medical specialist (rehabilitation, orthopedic surgeon or rheumatologist) by x-ray * with disease evolution of more than 3 months and less than 12 months * that give their informed consent by writing exclusion criteria: * previous shoulder surgery patients * patients with shoulder affections treated with shockwaves or corticosteroid injections.
database and biobank of patients with hypersensitivity pneumonitis

Conditions: Hypersensitivity Pneumonitis

Summary: sub-study of the main pulmonary fibrosis biomarker (pfbio) cohort (nct02755441), recruiting patients with an mdt-diagnosis of hypersensitivity pneumonitis (hp). patients are included for the collection of blood samples and regular clinical data. the database and biobank will be available for studies of hp, and can be directly compared to the main pfbio cohort, which has recruited patients with idiopathic pulmonary fibrosis (ipf) since 2016. biomarkers will be assessed as diagnostic and prognostic. further subtyping of hp, based on blood markers (including precipitins) will also be possible with the pfbio-hp project.


Eligibility criteria:
inclusion criteria: * diagnosis of hp at an mdt conference according to the current international guidelines * age of 18 years or older * the patients must be capable of giving informed consent exclusion criteria: - unable to sign informed consent

Keywords: biomarker prognosis diagnosis phenotyping genotyping
analysis of sexual bias in type 2 innate lymphoid cells (ilc2) in asthmatic patients

Conditions: Asthma

Summary: asthma is more common in females than in males but the difference has not been explained yet. group 2 innate lymphoid cells (ilc2) have recently emerged as critical players in the initiation of allergic responses but their implications in the difference between males and females in terms of asthma prevalence has not been fully studied. the aim of this project is to compare the proportion of ilc2 in blood between males and females with asthma.

asthma is more common in males until puberty but becomes more prevalent and more severe in females after puberty suggesting a protective action of male sex hormones. ilc2 have recently emerged as critical players in the initiation of allergic responses. the present team established that androgens, signaling through the nuclear receptor 3 c4 (nr3c4) androgen receptor (ar), negatively control ilc2 at steady state and during lung inflammation. relevant to this application, females with asthma have more circulating ilc2 than males. the present hypothesis is that harnessing ar signaling in ilc2 may provide a new therapeutic approach to down regulate tissue resident ilc2. this project will analyze the sex bias in circulating ilc2 in female and male patients with moderate to severe asthma. in females with asthma, the team will purify circulating ilc2 from peripheral blood mononuclear cells (pbmc) and expand them in vitro using cytokines and stromal cells in the presence of ar antagonist or agonist ligands. bulk ilc2 cultures at day 7 will used to measure the expression profile of various gene, including ar.

Eligibility criteria:
inclusion criteria: * asthma according to the criteria described by global initiative for asthma (gina) guidelines * severe asthma according to the criteria described by the american thoracic society (ats) / european respiratory society (ers) guidelines (for the recruitment of severe patients) * mild to moderate asthma based on low or medium dose of inhaled steroids according to gina guidelines exclusion criteria: * asthma exacerbations defined as oral corticosteroids related to worsening respiratory symptoms within the past 4 weeks * pregnant women * breastfeeding women * autoimmune diseases * androgen medication * early menopause defined as the absence of menstruation for at least 1 year * body mass index ≥ 30 kg/m² * weight \<40 kg * oral corticotherapy for more than 3 months * prediction of blood volume collected (care + research)\> 80 ml or\> 150 ml over a period of 30 days if blood collection within the past 30 days * known anemia with hemoglobin \<10 g/dl

Keywords: allergy type 2 innate lymphoid cells
relative bioavailability study of bicalutamide 50 mg tablet and casodex following a 50 mg dose in healthy subjects under fasting conditions

Conditions: Prostate Cancer; Hirsutism

Summary: the purpose of this study is to demonstrate the relative bioavailability of bicalutamide 50 mg tablet and casodex following a 50 mg dose in healthy subjects under fasting conditions.


Eligibility criteria:
inclusion criteria: * no clinically significant abnormal finding on physical exam, medical history, or clinical laboratory results on screening. exclusion criteria: * positive test results for hiv or hepatitis b or c. * treatment for drug or alcohol dependence.

Keywords: treatment
stratafix vs. vicryl oagb / mgb suture study

Conditions: Morbid Obesity; Anastomotic Leak; Anastomotic Stenosis; Hemorrhage Postoperative

Summary: to compare shorttime (6 months) results of two competitive suture materials with regard to time demanded to perform the concerned surgical step and secondary to study anastomotic site safety and complications like leakage and hemorrhage as well as development of anastomotic strictures. evaluation of cost-effectiveness.


Eligibility criteria:
inclusion criteria: * adult patients selected for primary mini-gastric bypass to treat obesity (bmi\>30) * laparoscopic access feasable (intention to treat laparoscopically) * failed conservative treatment (accepted by health insurance companies) * relevant co-morbidities in cases with bmi \<40 * age 18 years or elder exclusion criteria: * severe language problems * revisional or redo-procedures * operation intended as open procedure(extensive previous surgeries), * operation performed under corticoid-medication * operation performed under full-dose anticoagulants * operation performed by another surgeon than one of the 3 experienced mgb-surgeons of the department

Keywords: mini-gastric bypass one anastomosis gastric bypass gastroenteral anastomosis mgb oagb
cognitive impairment cohort study of the elderly population in shemountain

Conditions: Alzheimer Disease; Dementia; Neurodegenerative Diseases; Cognitive Impairment; Mild Cognitive Impairment

Summary: this study is a prospective observational study, which involves a cohort of 2000 all-sex and all-ethnic people aged 60 years and above with permanent residence in tianma area, shemountain town, songjiang district (suburban area), shanghai. demographic information, neuropsychiatric scale, peripheral blood, apoe genotype, brain mri, speech information, av45-pet, fdg-pet, tau-pet, glp-1r pet, and cholinergic receptor probe (asem) pet were collected and analyzed. follow-up visits were performed twice a year for 4 visits, and neuropsychiatric scales and biological samples were collected at each follow-up visit to construct a diagnostic model for patients with mild cognitive impairment, or alzheimer's disease, as well as a predictive model for the progression of cognitive impairment.

this study is a prospective observational study, which involves a cohort of 2000 all-sex and all-ethnic people aged 60 years and above with permanent residence in tianma area, shemountain town, songjiang district (suburban area), shanghai. demographic information, neuropsychiatric scale, peripheral blood serum aβ40, aβ42, p-tau 181, 217, urine proteomic analysis, apoe genotype analysis, brain mri, and speech information were collected and analyzed. after initial screening 20% of patients with clinically confirmed mci and ad were randomly selected for av45-pet, fdg-pet, tau-pet, glp-1r pet, and cholinergic receptor probe (asem) pet. follow-up visits were performed twice a year for 4 visits, and neuropsychiatric scales and biological samples were collected at each follow-up visit to construct a diagnostic model for patients with mild cognitive impairment, or alzheimer's disease, as well as a predictive model for the progression of cognitive impairment.

Eligibility criteria:
inclusion criteria: 1. all genders and all ethnic groups aged 60 and above with permanent residence in tianma area, shemountain town, songjiang district (suburbs), shanghai. 2. agree to collect neuropsychiatric scales, biological samples, imaging and other examination information. 3. agree to participate in this study and sign the informed consent form. and promise to abide by the research procedures, and cooperate with the implementation of the whole process of research exclusion criteria: 1. suffering from severe mental illness, tumor cachexia, severe liver and kidney dysfunction and other serious physical diseases and unable to cooperate 2. uncorrectable visual or auditory impairment that hampers the completion of related examination.

Keywords: alzheimer disease mild cognitive impairment cohort disease progression
the weekend effect and its possible influence on the prognosis of patients with non-varicose upper gastrointestinal bleeding

Conditions: Acute Upper Gastrointestinal Hemorrhage

Summary: the hypothesis is that the mortality of patients with non-varicose upper gastrointestinal bleeding after performing early gastroscopy who are admitted on weekends and night hours is higher than those admitted on weekdays or during daytime hours.

the aim of the study is to evaluate the impact of the schedule (day or night) and the day of admission (working or weekend / night) on the mortality of patients with non-varicose upper gastrointestinal bleeding after performing an early gastroscopy. a retrospective observational study will be carried out in patients admitted to the bleeding unit of the santa creu i sant pau hospital, where we observed hospital mortality and 30 days after performing an early gastroscopy, the duration of admission, signs of hemorrhagic activity in a period of less than 12 h. after early gastroscopy and types of endoscopic treatments, data will be collected by reviewing medical records. the number of patients expected to be included in this study is 1320 patients. patients will be included the day they enter the bleeding unit for an early gastroscopy.

Eligibility criteria:
inclusion criteria: * patients older than 18 years. * patients admitted to the bleeding unit with a diagnosis of upper gastrointestinal bleeding. * patients who have undergone an early endoscopy to determine the source of bleeding. * in case of readmissions during the study period, we consider only the admission closest to his death or discharge. exclusion criteria: * patients diagnosed with gastrointestinal bleeding varicose. * patients who present with gastrointestinal bleeding and did not perform early gastroscopy (during the first 24 hours) * patients admitted for different medical conditions, who developed upper gastrointestinal bleeding during the course of hospital stay.

Keywords: weekend effect non-varicose upper gastrointestinal bleeding
protocole advanced radiotherapy orl

Conditions: Head and Neck Squamous Cell Carcinoma

Summary: the purpose of this study is to do health economic evaluation of tomotherapy and dynamic arctherapy (2 techniques exist: rapidarc and vmat). this study evaluate also local disease control after 18 months in patients with an ent epidermoid carcinoma and treated by tomotherapy orarctherapy . the number of patients required in this study is: 300: * number of patients treated with tomotherapy: 120 * number of patients treated with dynamic arctherapy rapidarc: 120 * number of patients treated with dynamic arctherapy vmat: 60 this is a prospective; multicentric and non randomized study.


Eligibility criteria:
inclusion criteria: * ps \<= 2 * age \>= 18 years * histologically proven carcinoma * cavum epidermoïd or undifferentiated carcinoma; or oropharynx epidermoïd carcinoma; or oral cavity epidermoïd carcinoma * stade t1 to t4 * m0 * patient with no surgery ( except laser partial surgery and ganglionic cleaning out) * bilateral ganlionic cervical area irradiation * covered by a medical insurance. exclusion criteria: * prior history of other malignancies in the last 5 years(except non evolutive ent cancer or squamous cell carcinoma ) * re-irradiation indication * unilateral cervical area irradiation * post-operative radiotherapy * patient treated by amifostine * impossible follow-up

Keywords: tomotherapy head and neck squamous celle carcinoma health economic evaluation
preventing diabetes in those at risk by having a facilitator and family doctor encourage healthy activity and eating habits

Conditions: Prediabetes

Summary: nearly six million canadians are living with an increased risk of diabetes (prediabetes) and approximately 50% of these will develop type 2 diabetes within five years. the investigators wish to help these people change their lifestyle, to prevent them from getting diabetes. trials have shown that by supporting people with prediabetes to be more active and have healthier eating habits they can halve their risk. however, these interventions were very costly and not performed in canada. with the help of local family physicians and other health professionals (e.g. physiotherapy, psychology, endocrinology, nursing) the investigators have created a less expensive intervention suitable for the canadian population and health system. the investigators need to perform a study to see whether these modified approaches are practical for canadians and likely to be effective. people at risk will be invited to participate from family practices that have helped us in the initial stages of this program. family practices will be randomized to giving either the study intervention or continue with the physician's usual care. people receiving the intervention will have an appointment with their family doctor to discuss their exercise and eating habits and agree changes that are necessary. a prescription detailing these changes will be completed and signed by the family physician and participant. participants will be given the name of a lifestyle change facilitator (lcf) who will receive a copy of the prescription and contact the participant to help them set achievable goals. the lcf will contact participants once a month for six months to help them achieve these goals. the investigators eventual aim is to test this intervention in a large-scale randomized control trial. to achieve this it is necessary to pilot all aspects of the trial. information from the pilot study can then be used to design and perform a large-scale study effectively. the investigators hope that eventually the numbers of canadians progressing to having diabetes will be reduced.


Eligibility criteria:
inclusion criteria: * adults aged ≥ 18 years * hba1c of 5.7 to 6.4% and/or fpg of 6.1 to 6.9 mmol/l and/or a 2hr 75g ogtt of between 7.8 and 11.0 mmol/l exclusion criteria: * people with type i or ii diabetes * unstable angina * uncontrolled congestive heart failure * unstable arrhythmia * heart valvular disease * severe hypertension (systolic ≥ 200 or diastolic ≥ 120) * pregnant women or planning pregnancy within two years * life expectancy \< 1 year * waiting for major surgery * high risk of fracture * pregnancy or planning pregnancy
a phase i / ii trial of nintedanib in asian hepatocellular carcinoma patients

Conditions: Carcinoma, Hepatocellular

Summary: this study is to evaluate the safety, appropriate dose, and efficacy of bibf 1120 in liver cancer patients


Eligibility criteria:
inclusion criteria: 1. hepatocellular carcinoma, either histologically/cytologically confirmed or clinically diagnosed, which is not amenable to curative surgery or loco-regional therapy 2. age 18 years or older 3. eastern cooperative group performance score of 2 or less 4. child-pugh score of 7 or less 5. written informed consent in accordance with international conference on harmonisation (ich) and good clinical practice (gcp) and local legislation exclusion criteria: 1. prior systemic therapy for metastatic/unresectable hepatocellular carcinoma (for phase ii) 2. more than one line of prior systemic therapy for metastatic/unresectable hepatocellular carcinoma (for phase i) 3. uncontrolled or refractory ascites to adequate medical therapy 4. bilirubin greater than 1.5 times upper limit of normal 5. aspartate amino transferase or alanine amino transferase greater than 5 times upper limit of normal 6. absolute neutrophil count less than 1500/microliter 7. platelet count less than 75000/microliter 8. hemoglobin less than 9 g/dl 9. serum creatinine greater than 1.5 times upper limit of normal