effect of ketamine infusion in patients with copd applied one lung ventilation

Conditions: Chronic Obstructive Pulmonary Disease Mild; Chronic Obstructive Pulmonary Disease Moderate; Chronic Obstructive Pulmonary Disease Severe; Lungcancer; Anesthesia

Summary: chronic obstructive pulmonary disease (copd) patients often undergo thoracic surgery due to lung cancer and emphysematous changes. one lung ventilation (olv) used in thoracic surgery aggravates hypoxia and hypercapnia increasing intrapulmonary shunt and dead space.ketamine provide bronchodilation by inhibiting the reuptake of catecholamines in the circulation. it also serves relaxation of bronchial smooth muscle. our aim in this study, effects of ketamine on arterial oxygenation, the shunt fraction and the lung mechanics in patients with copd who administered olv because of thoracic surgery. thirty patients with copd who undergo thoracotomy for lung lobectomy will be included in this study. patients will be randomly divided to a control group (%0,9 saline- cg) or a keta (ketamine- kg) group. kg will be administered 1 mg/kg ketamine bolus, then 0,5 mg/kg/hour ketamine infusion after the induction, cg will be administered sline bolus, then saline infusion. peak airway pressure (ppeak), plato airway pressure (pplato), static compliance, shunt fraction, pao2/fio2 and arteriel blood gas values (pa02, pac02) will be recorded before initiation of olv and 30 minutes intervals after initiation of olv.to evaluate the postoperative pulmonary complications, pa02, pac02 in blood gas and pa02/fi02 values will be recorded 20 minute after arrival at postoperative care unit. patients will be evaluated for pneumonia, atelectasis and acute lung injury at postoperative 72 h and findings will be recorded. 30 day mortality will be recorded.

chronic obstructive pulmonary disease (copd) is a risk factor for cardiopulmonary morbidity and mortality after thoracic surgery. the elastic recoil reduction and structural changes in the small airways and alveoli cause pulmonary air trapping and hyperinflation in patients with copd. chronic alveolar hypoxia results structural changes in the pulmonary arteriol such as medial hypertrophy and muscularization. ventilation-perfusion mismatch and from the right to left shunt cause hypoxia in patients with copd. copd patients often undergo thoracic surgery due to lung cancer and emphysematous changes. one lung ventilation (olv) used in thoracic surgery aggravates hypoxia and hypercapnia increasing intrpulmonary shunt and dead space. positive end expirium pressure (peep) and alveolary recruitment are not applicable to treat hypoxia because of development of high intrinsic peep. ketamine is an intravenous general anesthetic agent widely used for many years and has sympathomimetic bronchodilator features on the airway. ketamine provide bronchodilation by inhibiting the reuptake of catecholamines in the circulation. it also serves relaxation of bronchial smooth muscle. our aim in this study, effects of ketamine on arterial oxygenation, the shunt fraction and the lung mechanics in patients with copd who administered olv because of thoracic surgery. this prospective, randomized, double blinded, controlled study will be conducted following cukurova university faculty of medicine ethics committee approval and written informed patient consent. thirty patients who undergo thoracotomy for lung lobectomy will be included in this study.patients will be monitored for electrocardiography (ecg), oxygen saturation (sa02) and non-invasive blood pressure and applied thoracal (t 5-8) epidural catheter which will be used postoperative analgesia. after the induction of anesthesia, patients will be intubated with double lumen tube (dlt). the position of the dlt will be confirmed with fiberoptic bronchoscope. anesthesia will be maintained with %4-6 desflurane and 0,25-0,5 microgram/dk/min remifentanil. desflurane will be titrated to maintain a bispectral index of 40 to 60.patients will be randomly divided to a control group (%0,9 saline- cg) or a keta (ketamine- kg) group. kg will be received 1 mg/kg ketamine bolus, then 0,5 mg/kg/hour ketamine infusion will be administered until the end of operation, cg will be received bolus saline, then saline infusion will be administered until the end of operation . patients will be ventilated with volume controlled ventilation (vcv), tidal volume (tv) 8 mlt/kg and rate of inspirium:expirium (i:e)=1:2,5 during two lung ventilation. during olv, the lungs were ventilated with vcv, tv 5 mlt/kg, i:e=1:2,5, peep= 5cmh20. the fraction of inspired oxygen (fi02) will initially set at 0,6. in cases of desaturation to sa02 less than 95%, fi02 will be increased by 0,2 up to 1,0. peak airway pressure (ppeak), plato airway pressure (pplato), static compliance, shunt fraction and arteriel blood gas values (pa02, pac02) will be recorded before initiation of olv and 30 minutes intervals after initiation of olv. to evaluate the postoperative pulmonary complications, pa02, pac02 in blood gas and pa02/fi02 values will be recorded 20 minute after and 1 hour after arrival at postoperative care unit. if the patient shows signs of dyspnea and pa02/fi02\<300, the patient will be admitted intensive care unit. patients will be evaluated for pneumonia, atelectasis and acute lung injury at postoperative 72 h and findings will be recorded. 30 day mortality will be recorded.

Eligibility criteria:
inclusion criteria: * age more than 40 years * american society of anesthesiologists' physical status 2-3 * diagnosis of copd * forced expiratory volume in 1 second (fev1) ≥ %50 in a preoperative pulmonary function test. exclusion criteria: * heart failure * severe functional liver or kidney disease * pregnancy, * obesity (bmi≥30) * respiratory failure (pa02\ 55 mmhg)

Keywords: ketamine one lung ventilation chronic obstructive pulmonary disease