Kornimate/medical-research-clean huggingface dataset:
neostigmine for ultrasound guided supraclavicular brachial plexus block

Conditions: Postoperative Pain

Summary: patients were randomly allocated into two equal study groups each contain (40) patients : patients in group a received supraclavicular block using 25ml of 0. 5% bupivacaine and 1 ml normal saline and patients in group b received 25 ml 0. 5% bupivacaine and 1 ml neostigmine (0.5 mg). the investigators found that neostigmine when used as an adjuvant to bupivacaine in ultrasound guided supraclavicular brachial plexus block has advantage over bupivacaine alone especially in the quality of sensory block and provide safe and effective post-operative analgesia in patients undergoing forearm surgeries

all patients were assessed with regards to: hemodynamics (heart rate, bp) and oxygen saturation were recorded preoperatively just before the block as a baseline value, immediately after the block 5, 20, 30,40,45 , 60 minutes during the operative time and 1, 2, 4, 6, 9 and 12 hours after end of operation. onset time of sensory block, onset time of motor block, duration of sensory block, and duration of motor block. pain assessment using a scoring system based on the visual analogue pain scale(vas) measured at the following time intervals 0, 2, 4, 6, 9, 12 and 24 post operatively, time to first analgesic requirement (in hours) and total analgesic consumption was monitored in the two groups for 24 hours in ward. the incidence of adverse effects whether related to the drugs used in the technique or related to the technique itself were recorded. the results of this study found that demographic (age, sex, weight and asa classification and surgical duration were statistically insignificant between the two groups. hemodynamics (hr and bp) were statistically significant between the groups .they were lower in neostigmine groups. as regard onset of sensory and motor block were clinically and significantly earlier in group b than group a ( p \< 0,05) and the same for duration of sensory and motor block were clinically and significantly longer in group b than in group a ( p \< 0,05 ). regarding visual analogue pain scale (vas), while comparing the two groups, the differences were significant at 9 and 12 hours after surgery for the favor of the neostigmine groups . the time to first analgesic request was significantly longer in group b than group a.

Eligibility criteria:
inclusion criteria: 1. asa ( i-ii) 2. age: from ≥18 years 3. sex: male or female 4. type of operation : forearm orthopedic surgeries 5. type of anaesthesia : supraclavicular brachial plexus block 6. duration of operation : 60-90 min exclusion criteria: 1. patient refusal for the procedure 2. any bleeding tendency 3. neurological deficits involving brachial plexus 4. patients with allergy to local anesthetics 5. local infection at the site of injection 6. patients on any sedatives or antipsychotics 7. body mass index \>35.

Keywords: neostigmine bupivacaine supraclavicular brachial plexus block
ultrasound and paediatric endotracheal tube size

Conditions: Uncuffed Endotracheal Intubation

Summary: the aim of the present study was to evaluate the role of ultrasound in paediatric patients to compare the correct size of an uncuffed endotracheal tube (ett) with the minimal transverse tracheal diameter (mttd) measured by ultrasound and with tube size predicted by different age-related formulas. the investigators hypothesize that a prediction of pediatric ett is possible with the ultrasonographic measurement of the mttd.


Eligibility criteria:
inclusion criteria: * written informed consent * children \<= 5 years of age * elective surgery requiring endotracheal intubation exclusion criteria: * missing informed consent * allergy to ultrasound gel

Keywords: ultrasound minimal transverse tracheal diameter endotracheal tube size paediatric age-based formulas sonographic measurement of the trachea
surgery versus manual rupture for dorsal carpal ganglion

Conditions: Dorsal Carpal Ganglion

Summary: this study objectives are to compare the efficacy and safety between surgical excision and manual rupture for dorsal carpal ganglion.the participants with dorsal carpal ganglion will be randomized into 2 groups:surgical excision or manual rupture.the patients will be follow-up for at least 1 yr.telephone interview will be used for outcome assessment.


Eligibility criteria:
inclusion criteria: * patients with dorsal carpal ganglion exclusion criteria: * underlying rheumatic condition * bleeding tendency

Keywords: surgery manual rupture dorsal carpal ganglion
ici-vph: impact of hpv immunisation schedules against hpv

Conditions: Human Papillomavirus Infections

Summary: this randomised clinical trial aims to determine whether an immunization schedule comprising two doses of gardasil administered six months apart is non-inferior to a schedule comprising three doses administered at 0, 6 and 60 months for the prevention of hpv-16 and hpv-18 infections that persist for at least six months, up to ten years after the initial vaccination. the study hypothesis is that the two-dose schedule would offer similar protection as that of a three-dose schedule against persistent hpv-16/18 infections.


Eligibility criteria:
inclusion criteria: * having received two doses of gardasil in 2008-2009, 2009-2010,2010-2011 or 2011-2012 according to 0, 6 months schedule (between 4 and 12 months) * resident of the regions chosen for the study exclusion criteria: * being considered immunosuppressed at time of vaccination (9-10 years-old) or at recruitment visit * being pregnant at recruitment visit
a treatment for severe inflammatory acne subjects

Conditions: Acne Vulgaris

Summary: demonstrate that a daily treatment regimen of adapalene 0.3%/benzoyl peroxide 2.5% gel + oral doxycycline 200 mg is effective and safe in severe inflammatory acne with 3 or fewer nodules or cysts (non-nodulocystic) during a 12-week treatment period.

this phase 4, 12-week, single-arm, open-label, multi-center investigational efficacy and safety study was conducted in subjects with severe inflammatory acne. subjects who met the inclusion criteria and none of the exclusion criteria at the screening visit returned to the clinic for baseline measures (week 0) and to start treatment, which continued for up to 12 weeks. treatment consisted of 2 investigational study drugs: * a/bpo 0.3%/2.5% gel applied to dry skin as directed by study staff once daily for 12 weeks, at night after washing. * doxycycline hyclate 200 mg: each subject was to take 2 50-mg tablets of doxycycline hyclate in the morning and 2 at night, for a total of 4 tablets (a total of 200 mg) daily for 12 weeks.

Eligibility criteria:
key inclusion criteria: 1. male or female subjects, 12 years of age or older at screening visit. 2. subjects with a clinical diagnosis of severe inflammatory acne (iga score of 4). 3. subjects with 4 or fewer nodules or cysts \> 1 cm in diameter on the face. 4. subjects 18 years of age or older must read and sign the informed consent form, which includes photography consent and hipaa authorization, prior to any participation in the study. consent will be obtained prior to any study-related procedures. subjects under the age of 18 years must sign an assent to participate form to participate in the study and must have one parent or guardian read and sign the informed consent form prior to any study-related procedure. (the parent or guardian is not required to attend the following visits unless requested.) key exclusion criteria: 1. subjects with nodulocystic or conglobate acne, acne fulminans, or secondary acne (chloracne, drug-induced acne, etc.). 2. subjects with 5 or more acne nodules or cysts \> 1 cm in diameter on the face at screening and baseline visits. 3. female subjects who are pregnant, nursing, or planning a pregnancy during the study. 4. subjects who have used any systemic therapy directed at improving acne, including antibiotics, within 30 days prior to baseline visit. 5. subjects who are at risk in terms of precautions, warnings, and contraindications for the investigational study drugs (see appendix 14.1 for package inserts for adapalene 0.3%/benzoyl peroxide 2.5% gel and doxycycline hyclate tablets). 6. subjects with any other condition or circumstance which, in the investigator's opinion, may put the subject at risk (e.g., a history of significant renal disease with impairment of renal function), confound the study results, or interfere with the subject's participation in the study. 7. sponsor and study site staff, relatives of staff members, or other individuals who would have access to the clinical study protocol.
pharmacokinetic evaluation of moxifloxacin iv to enteral switch therapy in intensive care patients

Conditions: Pneumonia

Summary: in the intensive care (ic)-unit moxifloxacin treatment is often started with intravenous administrations. as moxifloxacin is known to have a high oral bioavailability in healthy volunteers, patients are switched to oral or enteral therapy as soon as possible. however, no data on plasma levels for moxifloxacin during such a switch-therapy in ic-patients are available. therefore, this study aims to evaluate the moxifloxacin-plasma levels and their inter-individual variability during iv to enteral switch therapy in ic-patients.


Eligibility criteria:
inclusion criteria: * ic patients treated with 400 mg moxifloxacin iv (once a day) that can be switched to enteral administration of 400 mg moxifloxacin. * iv steady state * hemodynamic stability * normal enteral feeding without prokinetics * presence of arterial line * informed consent * ≥ 18 jaar exclusion criteria: * dialysis patients * creatinine clearance \< 30 ml/min * transaminase levels \> 5x upper limit
topical delivery of vitamin d3 as vitamin d supplementation

Conditions: Vitamin D Deficiency

Summary: after obtaining the approval from the irb of university of dammam and informed consent from 550 healthy patients, with vitamin d deficiency and vitamin d insufficiency and deficiency were recruited. age, weight and height will be taken, a detailed history, meticulous clinical examination was performed to rule out any diseases and complete blood picture, serum calcium, phosphorous, alkaline phosphatase, parathormone and 25 hydroxy-vitamin d (25ohd) will be done. 25-hydroxy vitamin d3 was measured in house by chemiluminescence immunoassay (clia) and ≥30ng/ml was taken as normal, 21-29ng/ml as insufficiency and ≤20 ng/ml as deficiency. the participants were divided into two groups of 350 in study arm and 200 in control arm. all participants were instructed not to change their dietary habits and life style till the study was over. the study group of women were instructed to apply to apply top-d (proniosomal delivered- vitamin d3) 1 gram containing 5000 iu of vitamin d3. the second group used 1 gram of aloe vera gel. the participants had no knowledge to which group they belong. a second blood sample was taken at the end of 4 months and the data was entered in the data base and analyzed using spss inc version 19.

after obtaining the approval from the institutional review board (irb) of university of dammam and informed consent from 550 healthy patients, with vitamin d deficiency and vitamin d insufficiency and deficiency were recruited. age, weight and height will be taken, a detailed history, meticulous clinical examination was performed to rule out any diseases and complete blood picture, serum calcium, phosphorous, alkaline phosphatase, parathormone and 25 hydroxy-vitamin d (25ohd) will be done. 25-hydroxy vitamin d3 was measured in house by chemiluminescence immunoassay (clia) and ≥30ng/ml was taken as normal, 21-29ng/ml as insufficiency and ≤20 ng/ml as deficiency. the participants were divided into two groups of 350 in study arm and 200 in control arm. all participants were instructed not to change their dietary habits and life style till the study was over. the study group of women were instructed to apply to apply top-d (proniosomal delivered- vitamin d3) i gram gram containing 5000 iu of vitamin d3. the second group used 1 gram of aloe vera gel. the participants had no knowledge to which group they belong. a second blood sample was taken at the end of 4 months and the data was entered in the data base and analyzed using spss inc version 19.

Eligibility criteria:
inclusion criteria: all men and women with vitamin d insufficiency and deficiency must be able to apple the topical vitamin d3 must be willing to sign and informed consent exclusion criteria: * those who have normal 25ohd levels
sequential oxygen therapy strategy for patients with covid-19

Conditions: Coronavirus Disease-2019

Summary: all patients with covid-19 were divided into three groups according to their illness: mild patient who receive conventional oxygen therapy, severe patients who receive nasal high flow oxygen inhalation or non-invasive positive pressure ventilation，all the oxygen therapy will be used as part of the standard of care. each group will enroll 10 patients, the treatment of all patients will be continuously optimized during observation, and the incidence of respiratory failure, intubation rate, 28 day mortality rate, icu hospitalization days, etc will be recorded and analyzed so to optimize the treatment time window of sequential oxygen therapy


Eligibility criteria:
inclusion criteria: * patients diagnosed with covid-19 * aged between 18-75 years; * willing to sign the informed consent voluntarily. exclusion criteria: * patients with active tuberculosis, idiopathic pulmonary fibrosis, bronchial asthma, bronchiectasis, pulmonary embolism, chronic respiratory failure or other serious respiratory diseases; ② patients with serious cardiovascular and cerebrovascular diseases (malignant arrhythmia, unstable angina, acute myocardial infarction, cardiac function grade 3 or above, stroke, cerebral hemorrhage, etc.); ③ patients with serious hepatorenal diseases (serious liver diseases refer to cirrhosis, portal hypertension and varicose bleeding, and serious kidney diseases include dialysis and kidney transplantation); ④ tumor patients who have undergone resection, radiotherapy and chemotherapy within 5 years; ⑤ patients who have difficulty in activity due to neuromuscular diseases; ⑥ patients with serious arthritis; ⑦ patients with serious peripheral vascular diseases; ⑧ pregnant and lactating women; ⑨ with severe cognitive and mental disorders; ⑩ the clinical researchers who were participating in other interventions within one month before selection;

Keywords: sars-cov-2 covid-19 oxygen treatment
stress management training for healthy aging

Conditions: Psychological Stress; Loneliness

Summary: this study is a two-arm randomized controlled trial comparing two 8-week stress management programs for reducing inflammation and improving well-being among older adults.

a growing body of literature has demonstrated how stress can affect social relationships, health, and well-being during the aging process. here, the investigators will test how two different programs can be used to facilitate healthy aging by helping individuals manage stress. one program will teach participants mindfulness meditation techniques while the other will educate participants about how to manage their health. n=188 older adults will visit the study's central laboratory for a baseline visit and complete several days of daily experience sampling before being randomized into one of the two 8-week stress management programs. participants will complete several days of daily experience sampling at the midpoint and conclusion of the intervention before returning to a study site to complete a follow-up assessment at both 1-week and 3-months after the end of the program. this project will provide important information about how each training program can be used to promote well-being, health, and better social functioning in older adults. this work will ultimately inform the design of more efficacious and efficient stress-management interventions to facilitate healthy aging.

Eligibility criteria:
inclusion criteria: * english speaking exclusion criteria: * \[exclusion criteria are masked from public viewing until data collection is complete. please contact project managers.\]
one session virtual reality during ongoing treatment for anxiety: feasibility in children and adolescents

Conditions: Anxiety Disorders; Exposure; Social Anxiety Disorder

Summary: the goal of this study is to evaluate one session with exposure with virtual reality (vr) in in children and adolescents, aged 8-18 years with an anxiety disorder. the main questions it aims to answer are: 1. what are the expectations of children and adolescents and therapists with vr exposure? 2. what is the acceptability of the vr session (positive and negative effects)? 3. what are possible working mechanisms of vr exposure? during ongoing treatment, participants will receive a session of exposure with vr.

cognitive behavioral therapy is an effective treatment for anxiety disorders, with exposure as the most important working ingredient. exposure therapy can be challenging to implement in face-to-face settings. virtual reality (vr) has emerged as a promising tool for delivering exposure therapy. in the current study, the researchers will examine children and adolescents that will participate in a single session of vr exposure during their regular treatment (n=30). willingness to participate in exposure in vivo will be assessed directly before and directly after the session. during the session anxiety, idiosyncratic expectations, and self-efficacy will be assessed. expectations will be measured before the session and acceptability after the session.

Eligibility criteria:
inclusion criteria: * children and adolescents 8-18 years old. * meeting diagnostic and statistical manual of mental disorders -5 criteria for an anxiety disorder, based on a semi-structured interview (scid-5 jr, specific section) or clinical judgment of an experienced and authorized clinician. exclusion criteria: * severe psychiatric symptoms other than anxiety disorder interfering with safety or warranting immediate intervention, e.g. psychosis or acute suicidality.

Keywords: children adolescents virtual reality exposure anxiety disorders
mucosal injury using pharyngeal packing

Conditions: Sore Throat

Summary: after approval of the institutional review board and written patient´s informed consent patients with indication for surgery of the sinuses were randomly assigned to one of the two study groups. after standardized anaesthetic management and ponv prophylaxis routinely applied the patients were screened for mucosal injury on second postoperative day. furthermore, the amount of analgetic and anti-emetic drugs and the severity of pain and ponv were recorded throughout the hospital stay.

aim of the study post-operative nausea and vomiting (ponv) is a complication of anaesthesia and responsible for malaise of surgical patients. furthermore, ponv has been shown causing additive costs due to anti-emetic drugs and prolonged hospitalisation. the occurrence of ponv is multifactorial. beside individual patients factors, opioid use and type of surgery seem to be responsible for occurrence of ponv. especially, sinus surgery carries a high risk of ponv. blood from the operation site entering the stomach has been discussed the potential cause for ponv in this specific patient population. therefore, hypopharyngeal packing following orotracheal intubation is a common clinical practice to prevent blood passing through the esophagus and so to lower the incidence of ponv. unfortunately, there are limited data data supporting the effectiveness of this procedure. in contrast, some references suggest that hypopharyngeal packing may be associated with postoperative mucosal injury and sore throat with high impact on patients´ well-being. to evaluate the usefulness and safety of hypopharyngeal packing the investigators perform prospective randomized study with the following objective: 1. does pharyngeal packing during sinus surgery increase the incidence of mucosal injury?

Eligibility criteria:
inclusion criteria: * surgery of the sinuses * patients over 18 years of age * duration of surgery \> 1h exclusion criteria: * refusal of the patient * patients under 18 years of age * chemotherapy with antiemetic medication * combined surgery (for example tonsillectomie and sinus surgery) * pregnancy
observational study of safety and tolerability of levemir™ flexpen™ (insulin detemir) in the treatment of type 1 and type 2 diabetes mellitus

Conditions: Diabetes; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2

Summary: this study is conducted in asia. the aim of this observational study is to evaluate the safety and tolerability of levemir™ flexpen™ (insulin detemir) in the treatment of filipino patients with type 1 and type 2 diabetes mellitus.


Eligibility criteria:
inclusion criteria: * patients diagnosed with type 1 or type 2 diabetes mellitus. * newly diagnosed insulin naive patients * patients currently on human insulin or on basal insulin * patients prescribed with levemir™ flexpen™ (insulin detemir) therapy * usage should be in accordance with the current prescribing information (see attached prescribing information) exclusion criteria: * previous history of hypersensitivity to insulin detemir (levemir™) and its excipients (see attached prescribing information) * contraindications and warnings specified in the current prescribing information (see attached prescribing information) * pregnant women, those planning to become pregnant, or women who are breastfeeding * patients who are already on human premix or premix analogue (unless they are going to be shifted to basal-bolus therapy) * children below 6 years old
masks against surface-scanning for radiation therapy immobilisation in head and neck cancer (massc)

Conditions: Head and Neck Neoplasm

Summary: the purpose of this study is to investigate the feasibility of using open masks or no masks in combination with optical surface scanning for radiotherapy in patients with head and neck cancer.


Eligibility criteria:
inclusion criteria: * patients ≥ 18 years old * histologically confirmed head and neck cancer. * patients treated with radiotherapy (rt) as primary treatment. * an eastern cooperative oncology group (ecog) performance status grade of 0-1 as defined in appendix 3. * each subject must sign an informed consent form (icf) indicating that he understands the purpose of and procedures required for the study and is willing to participate in the study. * patients must be willing to comply with treatment plan and other study procedures exclusion criteria: * patients with significantly altered mental status or with psychological, familial, sociological or geographical condition potentially hampering compliance with the study. * patients who cannot stay still during fraction because of a disorder (e.g. parkinson's disease)

Keywords: radiotherapy radiotherapy, image-guided