Kornimate/medical-research-clean huggingface dataset:
a trial evaluating autologous endometrial co-culture versus conventional medium in the treatment of infertility

Conditions: Infertility

Summary: one of the main factors in the success of in-vitro fertilization is the quality of the environment of the embryo. in contrast to maternal age, the environment in which the embryo develops is a modifiable factor. many techniques, such as assisted hatching and perfecting culture media have been attempted in order to reproduce as much as possible the natural, physiological environment of the mother for the embryo in in-vitro fertilization. however, the different new culture media used are devoid of growth factors normally secreted by uterine cells that enhance the interaction between the embryo and its environment. because the endometrial lining of the uterus secretes many different cytokines necessary for growth of the embryo, a new procedure has been developed to mimic the natural environment of the growing embryo using autologous (patient's own) endometrial cells in co-culture with the embryo. endocell, a product developed by genévrier laboratories, received commercial authorization in france in 2011. it is the only system of autologous embryo-endometrium co-culture available on the actual market. the process consists of developing the embryo on a monolayer of the patient's own endometrial cells in order to favor its growth until the blastocyst stage (day 5) and to improve its implantation.


Eligibility criteria:
inclusion criteria: * undergoing in vitro fertilization (ivf) or ivf/intra cytoplasmic sperm injection (icsi) at ovo clinic * having a prescription of a long, short or an antagonist ivf protocols using both urinary and synthetic gonadotropins * having a single embryo transfer * regular menstrual cycles * basal follicle stimulating hormone levels less than 10 iu/l within 6 months prior to entering the study * anti-mullerian hormone more than 1 ng/ml measured within a year * normal sonohysterogram or hysteroscopy done within the last 2 years * previously undergone a maximum of 3 ivf cycles * documented negative serology tests within 1 year prior recruitment for: hepatitis b, syphilis, hiv based on health canada recommendations for treatment in an ivf laboratory. exclusion criteria: * amenorrhea * anovulatory cycles * polycystic ovarian syndrome * chronic endometritis * severe endometriosis * hydrosalpinx * uterine synechia or asherman's syndrome * submucosal uterine fibroids or intra-cavitary polyps greater than 1cm * uterine anomalies * use of anticoagulants * secretory azoospermia

Keywords: in vitro fertilization autologous endometrial co-culture
application of transcutaneous electrical acupoint stimulation in laparoscopic cholecystectomy

Conditions: Pain Postoperative; Postoperative Recovery

Summary: to explore the application of transcutaneous electrical acupoint stimulation combined with transverse abdominis plane block in laparoscopic cholecystectomy, in order to reduce postoperative pain and promote postoperative recovery.

percutaneous electrical acupoint stimulation has been applied in preoperative prophylaxis, intraoperative anesthesia and postoperative rehabilitation, and can reduce perioperative anxiety, improve the efficacy of preoperative smoking cessation and alcohol abstinence, and shorten the preoperative fasting time. during surgery, it can reduce the amount of anesthetic drugs, anti-inflammatory and anti-stress effects, stabilize circulation, and protect important organs; after surgery, improve the speed and quality of wake-up of patients, promote the recovery of maintenance function, regulate immune function, and reduce postoperative adverse reactions such as postoperative pain, postoperative nausea and vomiting, postoperative urinary retention, etc. as one of the common nerve blocks, transverse abdominis block is used clinically, and its main function is to relieve perioperative pain and reduce the amount of traumatic stress and analgesic drugs

Eligibility criteria:
inclusion criteria: * american society of anesthesiologists (asa) class i and ii * age 18-65 years * laparoscopic cholecystectomy for the first time * there is no rupture, infection in the acupoint pasting site * the patient knows and signs the informed consent form exclusion criteria: * people with visual impairment, hearing impairment and alcoholism * history of diabetes, myocardial infarction or cerebrovascular accident, liver and kidney dysfunction * those who are allergic to non-steroidal drugs, anticholinergic drugs, and anesthetic drugs * those who are unable to cooperate or refuse to participate in the research or request to withdraw during the research process * those with contraindications to percutaneous electrical stimulation, including local skin damage, infection or implantation of electrophysiological devices in the body

Keywords: transcutaneous electrical acupoint stimulation postoperative pain visceral pain early recovery after surgery
agency in dystonia

Conditions: Dystonia, Primary

Summary: in this study, using computerized cognitive assessments combined with multi-modal neuroimaging approach investigators aim to address three specific questions on patients with cervical and myoclonus dystonia: (i) investigate various aspects of the sense of agency and relationship to the severity of dystonia symptoms, (ii) characterize the possible link between abnormalities of movement perception and alteration of sense of agency in dystonia, (iii) (identify the neuronal underpinnings of the defective sense of agency in dystonia.

this is a single-centre, two-group ( dystonia and control), case-control study using behavioural and novel multimodal neuroimaging techniques to address the study aims. the battery of the tasks will include explicit-agency tasks, a visual discrimination task on objects movement perception. the magnetic resonance acquisition protocol will include mp2rage structural (10 min duration), multi echo (3 echo times) multiband (mb factor 4) resting state functional neuroimaging (15 minutes duration) and multi shell diffusion imaging sequence (15 minutes duration)

Eligibility criteria:
inclusion criteria: * diagnosis of isolated adult-onset cervical dystonia (cd) or myoclonus dystonia (md); * duration of disease of more than one year * no botulinum toxin injection for at least three months before the study * normal or corrected-to-normal vision. exclusion criteria * any neurological history except for dystonia, * history of dopamine antagonist treatment, * secondary dystonia, * dystonia in the upper limbs, * inability to maintain gaze straight.
a study of ascending multiple doses of oral surotomycin in healthy participants (mk-4261-009)

Conditions: Clostridium Difficile Associated Diarrhea (CDAD)

Summary: this study aims to assess the safety, tolerability, and pharmacokinetics (pk) of oral doses of surotomycin (cb-183,315) administered for 14 consecutive days in healthy males and females.


Eligibility criteria:
inclusion criteria: * has no evidence of prior chronic gastrointestinal inflammatory disease such as inflammatory bowel disease * electrocardiogram (ecg) shows no clinically significant abnormalities * is in good health exclusion criteria: * pregnant or lactating females * has prior exposure to surotomycin * has received an investigational drug or participated in any experimental procedure within1 month prior to study entry and at least 6 half lives from last intake of study drug * participants 18 to 49 years of age that has taken any regular, prescribed, or over-the-counter medication * has any significant concurrent therapies * has a positive drug screen * has a positive human immunodeficiency virus (hiv), hepatitis b, or hepatitis c screen * has donated blood or blood products in the 60 days preceding screening * is an active intravenous drug user or abuses alcohol * has had a malignancy within the last 5 years * has inadequate protection against pregnancy during the conduct of the study and until 1 month after last dose of study drug * has received any antibiotics within 30 days prior to first dose of study drug * has known hypersensitivity to daptomycin
the impact of structured patient education material (spem) in improving clinical and behavioural outcomes in home-based cardiac rehabilitation program participants: a pilot study

Conditions: Ischaemic Heart Disease

Summary: this study aims to examine the impact of providing a digital education material to participants of home based cardiac rehabilitation in improving clinical and behavioural outcomes

this is a pilot study aiming to assess the impact of providing a structured patient education material in a digital form to participants of home based cardiac rehabilitation program in university malaya medical centre.

Eligibility criteria:
inclusion criteria: * age 20-70 years * fulfills the low to moderate exercise participation risk criteria for cardiac rehabilitation program phase 2 as per the american association of cardiovascular and pulmonary rehabilitation standards * able to participate in a treadmill exercise program * cognitively able to give consent, and able to read and utilize the digital education material exclusion criteria: * stratified as high risk to participate in an aerobic exercise program as per the american association of cardiovascular and pulmonary rehabilitation standards
neurological effects of chemotherapy and radiation therapy in patients with colon cancer

Conditions: Cognitive/Functional Effects; Colorectal Cancer; Long-term Effects Secondary to Cancer Therapy in Adults

Summary: rationale: learning about the long-term effects of chemotherapy and radiation therapy on brain function may help doctors plan cancer treatments. purpose: this clinical trial is looking at the neurological effects of chemotherapy and radiation therapy in patients with colon cancer.

objectives: primary * identify the nature and long-term ramifications of cns injury as a result of cancer treatment in patients with colon cancer. secondary * analyze differences in cognitive measures and mri data in these patients. * correlate mri measures with cognitive performance in these patients. outline: patients undergo cognitive performance assessment and mri. projected accrual: a total of 42 patients will be accrued for this study.

Eligibility criteria:
disease characteristics: * diagnosis of colon cancer * received chemotherapy and radiotherapy for colon cancer patient characteristics: * not specified prior concurrent therapy: * see disease characteristics

Keywords: cognitive/functional effects long-term effects secondary to cancer therapy in adults recurrent colon cancer stage i colon cancer stage ii colon cancer stage iii colon cancer stage iv colon cancer
study to assess the feasibility of stopping prostate cancer treatment early in elderly patients

Conditions: Elderly; Prostate Cancer

Summary: this study seeks to identify if it is feasible to stop luteinizing hormone-releasing hormone (lhrh) agonist therapy in elderly men with prostate cancer. we hypothesize that elderly prostate cancer patients on long term androgen ablation with lhrh agonists will be permanently castrated and do not require ongoing lhrh agonist therapy. participants will be monitored by testosterone testing throughout study.


Eligibility criteria:
inclusion criteria: * prostate cancer with \>3 years of lhrh agonist therapy. * age ≥70 years. * ecog performance status ≤2 * baseline testosterone of \< 20 ng/ml * no prior chemotherapy or lu-psma (unless survival predictions are favorable). * ability to understand and sign informed consent. exclusion criteria: * none
investigation of pharmacodynamic characteristics of explorative formulation of insulin degludec in male subjects with type 1 diabetes

Conditions: Diabetes; Diabetes Mellitus, Type 1

Summary: this trial is conducted in europe. the aim of this trial is to investigate the pharmacodynamic (the effect of the investigated drug on the body) of insulin degludec (insulin 454), an explorative formulation, not similar to the proposed commercial formulation, under single-dose and steady-state conditions in male subjects with type 1 diabetes.


Eligibility criteria:
inclusion criteria: * male and are considered to be generally healthy, except for the underlying diabetes mellitus, based on an assessment of medical history, physical examination and clinical laboratory data, as judged by the investigator * diagnosed with type 1 diabetes mellitus and treated with insulin for at least 12 months * body mass index (bmi) between 18.0 and 27.0 kg/m\^2 (both inclusive) * glycosylated haemoglobin a1c (hba1c) below or equal to 10.0 % based on central laboratory results exclusion criteria: * history of significant multiple drug allergies or with a known or suspected allergy to the trial product or any medicine chemically related to the trial product, as judged by the investigator * participation in any other trials involving investigational products within 3 months preceding the start of dosing
daily adaptive radiation therapy using an individualized approach for prostate cancer

Conditions: Prostate Cancer

Summary: this trial is a prospective, single-arm, multi-center clinical trial designed to assess whether adaptive radiotherapy with urethral sparing for low to intermediate risk localized prostate cancer will translate into a decreased rate of patient reported acute urinary side effects, as measured by the patient reported epic-26 questionnaire, compared with the historically reported rate for non-adaptive, non-urethral sparing prostate sbrt.


Eligibility criteria:
inclusion criteria: 1. patient has nccn low or intermediate risk prostate cancer that is biopsy proven. 2. prostate volume is ≤80cc as assessed by mri prior to radiotherapy. 3. aua/ipss score is ≤ 15. 4. ecog performance status is ≤2 (or karnofsky score is ≥60%). 5. patient has no pirads 4 or 5 lesion on prostate mri contacting the urethra (determined at physician discretion). 6. patient has the ability to complete required patient questionnaires. 7. patient age ≥ 18 years (or greater than the local age of majority). 8. patient has the ability to understand and the willingness to sign a written informed consent document. exclusion criteria: 1. patient has baseline grade ≥3 gi or gu toxicity 2. patient has had prior overlapping pelvic radiotherapy. 3. patient has had prior transurethral resection of the prostate, prostate hifu, or cryoablation. 4. patient has node positive prostate cancer. 5. patient has extracapsular extension (capsular abutment is permitted). 6. patient has active inflammatory bowel disease or active collagen vascular disease. 7. patient cannot undergo prostate mri. 8. patient cannot undergo prostate fiducial marker placement. 9. patient has ongoing receipt of cytotoxic chemotherapy (androgen deprivation therapy is allowed).
me-gc: a randomized controlled trial of meditation for genetic counselors

Conditions: Genetic Counseling Profession

Summary: this study is designed to determine whether meditation is beneficial for genetic counselors and genetic counseling students. the main goal is to see if meditation can help with professional well-being (burnout for genetic counselors, stress for genetic counseling students). the investigators will also explore whether meditation has other benefits for the genetic counseling profession.

the investigators will recruit 390-420 genetic counselors and 189-210 genetic counseling students. participants will be randomized into one of three groups of roughly the same size: two meditation groups and an observational group. all three groups will fill out online surveys at several points in the study. the only thing the observational group will be asked to do is fill out these surveys. the meditation groups will be asked to meditate for 10 minutes a day for 8 weeks. participants will be provided with an app or website that instructs them on how to meditate. outcome analyses will be done with an intention to treat approach. outcomes will be assessed using linear regression with the outcome variable as the dependent variable and baseline outcome measure, baseline mindfulness, and treatment group as the independent variables. secondary outcomes will be considered exploratory. the study is funded by the jane engelberg memorial foundation

Eligibility criteria:
inclusion criteria: * genetic counselors who provide direct clinical care * genetic counseling students * self-reported fluency in english exclusion criteria: * living outside the us
a web-based intervention study to reduce high-risk sexual behavior by persons living with hiv aids (plwh)

Conditions: Sexually Transmitted Infections; HIV Infections

Summary: this is a cctg sponsored trial in collaboration with ucsd-avrc investigators to get more information about the methods that are used on the internet to provide information on how to reduce the risk of giving or getting infections that are often or usually passed from one person to another during sexual or intimate contact (sexually transmitted infection (sti)). stis include chlamydia, gonorrhea and syphilis. the purpose of this study is to develop methods that will allow someone who is living with hiv an easy way that they can get information and learn of ways on their own that can decrease their chances of getting sexually transmitted infections and ways that they can reduce the chance that they may transmit hiv to others.

design: cctg 592 is a randomized, controlled study that will compare the efficacy of web-based intervention to reduce high-risk sexual behavior by persons living with hiv aids (plwh). duration: 48 weeks sample size: 200 subjects (100 per arm) that will be randomized study population: hiv-1-infected men who have sex with men (msm) at least 18 years of age who have a recent history of transmission risk behavior. stratification: subjects will be stratified based upon their baseline antiretroviral use, whether they have a home computer and by site.

Eligibility criteria:
inclusion criteria: * hiv-1 infection, as documented by any licensed screening antibody test, such as elisa, and confirmed by a second antibody test, such as western blot, or detectable plasma hiv-1 rna at any time prior to study entry. if an elisa or western blot are not available, hiv infection may be documented by two hiv rna values \> 2000 copies/ml, drawn at least 24 hours apart. the hiv rna assays should have been run at a clia approved laboratory or equivalent. * 18 years of age or older. * male. * at least one of the following: * an hiv negative or unknown status sexual partner in the past three months. * a sexually transmitted disease in the past 1 year (other than hiv). * more than 2 male partners in past year. * unprotected anal sex in past 3 month. * capable of signing written informed consent. * read and comprehend english * adequate computer skills for study. exclusion criteria: * uncontrolled psychiatric condition. * drug or alcohol users with use that in the opinion of the investigator, would limit follow-up and adequate consent

Keywords: sti msm hiv prevention men having sex with men
evaluation of prolidase in obstructive sleep apnea syndrome

Conditions: Obstructive Sleep-Apnea Syndrome

Summary: obstructive sleep apnea (osa) is a highly prevalent breathing disorder in sleep. we have aimed to evaluate the relationship between osa and prolidase activity, the oxidative stress index (osi), total antioxidative capacity (tac), and total oxidative capacity (toc) and the relationship between carotid intima media thickness (cimt).

this study was approved by the local ethics committee in accordance with the helsinki declaration. written informed consent was received from the osas subjects patients and control subjects before enrolment in the study. the patient and control cohorts were recruited from the pulmonary medicine department, medical faculty, yuzuncu yıl university. blood samples were analysed at the biochemistry laboratory of harran university medical faculty tac and tos levels were measured by using an automated measurement method. tac measurement method involves the production of a potent biological hydroxyl radical. ferrous ion solution is mixed with hydrogen peroxide. thus, it is possible to measure the anti-oxidative effect of the sample against the potent free radical reactions initiated by the production of the hydroxyl radical. tos method is based on the oxidation of ferrous ion to ferric ion in the presence of various oxidant species in acidic medium and the measurement of the ferric ion by xylenol orange. mmol trolox equivalent (equiv)/l, mmol h2o2 /l and mg/dl, respectively.

Eligibility criteria:
inclusion criteria: * patients were diagnosed with osa after night polysomnography (psg). * patients were enrolled in the study following receipt of their written informed consent. exclusion criteria: * patients had ischaemic cardiovascular diseases, * patients had chronic obstructive pulmonary diseases, * patients had ischaemic cerebral diseases, * patients had chronic inflammatory diseases, * patients had chronic and acute systemic infections.

Keywords: prolidase activity obstructive sleep-apnea syndrome
transmuscular quadratus lumborum block for laparoscopic cholecystectomy

Conditions: Cholecystitis; Pain

Summary: the tql block may prove a valuable method for treating postoperative pain following scopic removal of the gall bladder. the trial will compare active tql block versus placebo tql block after said operation. the hypothesis is that active tql block significantly will reduce postoperative pain following scopic removal of the gall bladder compared with placebo tql block.


Eligibility criteria:
inclusion criteria: * scheduled for elective laparoscopic cholecystectomy * received oral and written information about the trial * american society of anaethesiologists (asa) classification 1-3 * nrs score \> 3 upon arrival at the pacu area exclusion criteria: * cannot cooperate * does not speak or understand danish * allergy towards drugs used in the trial * large daily consumption of opioids * known alcohol og medicin abuse * difficult or impossible by ultrasound to visualise the intended nerve/tissue structures necessary to perform block * pregnancy

Keywords: laparoscopic cholecystectomy postoperative pain quadratus lumborum ultrasound
"maze out": a serious game to improve self-efficacy and mutual understanding in eating disorders.

Conditions: Eating Disorders

Summary: eating disorders (eds) are mental disorders with long recovery time and high mortality. despite the importance and extensive research in the field, an effective treatment for eds has yet to be found. in co-production with ed patients, clinicians, and technology experts a serious game called "maze out" was developed and initially evaluated through a feasibility study. maze out is an innovative first player tool focusing on improving self-efficacy, mutual understanding, and family functioning in adults with eds. the game has been evaluated through a usability study. study findings demonstrate that patients found maze out easy to use, meaningful and fun. the usability study was thus a first step in developing and testing an evidence-based intervention to be implemented in the treatment repertoire of adolescents and adults with eds. the present study is a randomized controlled trial, whereby the investigators will explore the effectiveness of maze out as an additional treatment to treatment as usual (tau)


Eligibility criteria:
inclusion criteria: * all sexes aged 18+ * diagnosis of anorexia nervosa, bulimia nervosa, other eating disorders and eating disorders unspecified (icd-10 codes: f.50.0-f.50.9) * receiving treatment from one of psychiatry centers in the mental health services of region south denmark, or in endocrinology services specialized in ed of region south denmark; or living in a mental health care institution in region of southern denmark. exclusion criteria: • no danish speaker

Keywords: serious games coproduction bulimia nervosa anorexia nervosa mhealth