Kornimate/medical-research-clean huggingface dataset:
reduction mammaplasty and improved quality of life

Conditions: Macromastia; Signs and Symptoms; Quality of Life

Summary: the data gathered here will be used to evaluate the efficacy and safety of the mammary reduction in patients with macromastia.

the data was gathered using retrospective and follow-up prospective study of a group of patients, consisting of adult women that underwent a breast reduction surgery at the clinic of plastic, reconstructive and aesthetic surgery faculty of comenius university and at the university hospital in bratislava, ružinov, during the time period between 2000 until may 2014. the data concerning the quality of life of these patients was gathered by using the globally standardized questionnaire "breast q questionnaire©" with the separate software system evaluation tool "qscore©". the statistical analysis was conducted using graphpadprism program v. 6.01. the total number of respondents consisted of 52 people who were followed-up for up to 12 years.

Eligibility criteria:
inclusion criteria: * above 18 years * macromastia on clinical examination * fulfilled breast q questionnaire prior to surgery and after surgery * signed informed consent exclusion criteria: * failed to sign informed consent * failed to fill the breast q questionnaire * patients with altered mental status and behaviour * patients with concomitant breast disease, or with previous breast interventions as are radiotherapy, surgery, or breast cancer
the effectiveness and safety of ultrasound elastography guided pleural biopsy in the differential diagnosis of benign and malignant pleural effusion

Conditions: Pleural Effusion

Summary: the goal of this clinical trial is to evaluate the diagnostic effcacy and safety of ultrasound elastography guided pleural biopsy in the differential diagnosis of benign and malignant pleural effusion. the main question it aims to answer are: the effectiveness and safety of ultrasound elastography guided pleural biopsy in the differential diagnosis of benign and malignant pleural effusion. participants will undergo ultrasound elastography guided pleural biopsy or traditional ultrasound-guided pleural biopsy.


Eligibility criteria:
inclusion criteria: 1. patients with unexplained pleural effusion (patients with pleural effusion with negative aspiration) 2. sign the informed consent form 3. the patient must have chest ct, biochemical examination of pleural fluid, cytological examination of pleural fluid and other data before operation exclusion criteria: 1. the cytological examination of pleural fluid indicates "highly suspicious" patients (unless the cytological examination results of patients are inconsistent with clinical manifestations and ct examination). the pleural fluid cytology proved to be malignant. patients with severe pleural adhesion who cannot undergo medical thoracoscopic examination will not be randomly selected, and elastic ultrasound-guided biopsy can be performed after informed consent, as a subgroup of population analysis. those who cannot tolerate closed pleural biopsy due to severe cardiopulmonary dysfunction and poor general condition coagulation dysfunction. leakage. the age is less than 18 years old. 2. the pleural fluid cytology proved to be malignant. 3. patients with severe pleural adhesion who cannot undergo medical thoracoscopic examination will not be randomly selected, and elastic ultrasound-guided biopsy can be performed after informed consent, as a subgroup of population analysis. 4. those who cannot tolerate closed pleural biopsy due to severe cardiopulmonary dysfunction and poor general condition 5. coagulation dysfunction. 6. transudate 7. the age is less than 18 years old.
improving primary care follow-up for patients with pelvic inflammatory disease

Conditions: Pelvic Inflammatory Disease

Summary: the investigators hypothesize that text message reminders to girls diagnosed with pelvic inflammatory disease (pid) in the emergency department (ed) will improve follow-up to their primary care provider (pcp) after being discharged from the ed.

the centers for disease control (cdc) recommends that patients diagnosed with pelvic inflammatory disease (pid) receive follow-up care within 72 hours of diagnosis. however, recent studies show that the majority of teenage girls diagnosed with pid do not receive this follow-up care within 72 hours. we hypothesize that text message reminders to girls diagnosed with pid in the emergency department (ed) will improve follow-up to their primary care provider (pcp) after being discharged from the ed.

Eligibility criteria:
inclusion criteria: * females aged 15 years and older * new diagnosis of pid, as defined by the 2006 cdc minimum criteria for diagnosis of pid, on current ed encounter * determined by attending physician to be appropriate for outpatient treatment exclusion criteria: * patient does not have a cell phone that is capable of receiving text messages * developmental disability * non-english speaking * pregnancy * patient who was enrolled in this study on a prior ed visit

Keywords: text message reminders pelvic inflammatory disease pid primary care follow-up emergency department care discharge instructions
effects of titrated oral tolvaptan 15-60 mg once daily (qd) on cognitive and neurological function in elderly hyponatremic patients

Conditions: Hyponatremia

Summary: demonstrate an improvement in the composite scores of validated neurocognitive tests in elderly subjects with chronic sub-clinical (i.e., asymptomatic) hyponatremia.

subjects will be randomized, with stratification by baseline sodium \<130 or ≥ 130 meq/l\[mmol/l\] to receive either tolvaptan 15 mg tablet or matching placebo tablet at doses of 15, 30 or 60 mg for 21 days. during this period, fluid restrictions should be loosened or suspended, until the subject's response to therapy can be evaluated, typically over the first few days of therapy. fluid restriction may be reinstituted at any time in subjects whose sodium fails to improve or worsens with study therapy. a forced-titration up to 60 mg of study drug by day 3 to 7 will be based on the subject's serum sodium subjects entering the study with a serum sodium concentration less than 130 meq/l\[mmol/l\] may be fluid restricted if necessary at the discretion of the investigator. subjects should be monitored closely during the first 24 hours of treatment for dosing titration. the total dosing duration will be up to 21 days (plus 3 day treatment window). subjects will return to the clinic on day 22 (+3 days) for assessments and will complete a follow-up visit on day 28 (+2 days).

Eligibility criteria:
inclusion criteria: * women and men 50 years of age or older. * serum sodium ≥123 and ≤ 134 meq/l \[mmol/l\]at screening and baseline. * subjects with serum sodium concentrations ≥118 and ≤122 meq/l\[mmol/l\] at screening and baseline may be entered into the trial based on consultation and approval from the study medical monitor. exclusion criteria: * conditions or history which may present a safety concern to the subject or their offspring or extreme susceptibility to hypotension with sudden fluid loss (aquaresis). * hyponatremia that is acute, easily reversible, artifactual, or due to a condition not associated with vasopressin excess or likely to respond to aquaretic therapy. * conditions associated with an independent imminent risk of morbidity and mortality. * conditions which may confound the assessment of endpoints, history of poor compliance, participation in a clinical trial believed by the pi or sponsor likely to confound endpoint assessments. * conditions which may confound primary endpoints of cognitive function.

Keywords: hyponatremia cognitive neurological function elderly
assessing the effectiveness of digital wellness modules on perceived quality of life

Conditions: Wellness; Quality of Life; Anxiety; Depression

Summary: the study will examine the role of digital wellness modules (brief mindfulness and light to moderate physical exercise) delivered through a smartphone wellness application and their short-term effects on health behavior motivation and change, and longer-term quality of life and non-pathological affective states.

primary objective: the primary objective of this parallel-assignment longitudinal study is to determine whether the digital wellness modules (e.g., mindfulness and light to moderate physical activity) increase quality of life and decrease stress, anxiety, and depression, as mediated by health behavior motivation and change in a healthy population of adults. secondary objective(s): the secondary objective is to ascertain qualitatively through deductive thematic analysis specific themes of a) key drivers of health behavior change; b) types of motivations that drive health behavior change, and c) implementation of sustained health behavior change. the study will be conducted virtually by yale university researchers.

Eligibility criteria:
inclusion criteria: * resides in united states exclusion criteria: * any individual who endorses any of the following criteria will be excluded from participation in this study: * positive health screening questions, as measured by the health screening questionnaire (hsq): * pain, discomfort or pressure in the chest, difficulty breathing or shortness of breath, dizziness, fainting, or blackout, blood pressure with systolic greater than 140 or diastolic greater than 90, diagnosed or treated for any heart disease, heart murmur, chest pain (angina), palpitations (irregular beat), or heart attack, heart surgery, angioplasty, or a pacemaker, valve replacement, or heart transplant, resting pulse greater than 100 beats per minute, any arthritis, back trouble, hip /knee/joint /pain, or any other bone or joint condition, personal experience or doctor's advice of any other medical or physical reason that would prohibit the participant from doing light to moderate physical exercise, personal physician's recommendation against participating in light to moderate physical exercise because of asthma, diabetes, epilepsy or elevated cholesterol or a hernia. * positive psychiatric disorders screening questions: * positive screen for depression, excluding suicide (phq-8) cutoff score \> 6 * positive screen for panic (smpd) cutoff score \> 2 * positive screen for generalized anxiety (gad-7) cutoff score \> 10 * positive screen psychosis (pdsq) via psychosis section, cutoff score \> 3 * positive screen mania via the altman self-rating mania scale (asrm) cutoff score \> 6

Keywords: digital wellness interventions wellness mental health mindfulness exercise
mini theta burst tms in mdd patients

Conditions: Major Depressive Disorder

Summary: this is not a treatment study. in this study, the researchers are primarily interested in examining whether functional mri (fmri)-guided transcranial magnetic stimulation (tms) may be more effective than traditional tms methods at temporarily influencing neural circuit communication. the investigators test this by combining tms and fmri technologies to probe and modulate brain activity. if the novel fmri-guided tms stimulation used in this study is more effective than traditional methods, future studies may utilize similar personalized tms targeting methods to yield even better clinical outcomes.

this study will involve a baseline magnetic resonance imaging (mri) scan, transcranial magnetic stimulation (tms), and tms interleaved with functional mri (fmri) scans. after screening, eligible participants will undergo a 1-hour mri scan, encompassing structural and functional scans to establish tms stimulation targets for subsequent visits. during the baseline tms/fmri session or pre-intervention tms/fmri, single pulses of tms and a short round of repetitive tms (rtms) will be administered to the participant's individualized target while functional mri scans (fmri) are collected. following this, participants will commence a short tms intervention regimen involving daily rtms over 3 consecutive days. the day after the intervention, participants will undergo another tms/fmri session, or the post-intervention tms/fmri, to capture potential changes from the 3-day intervention. clinical assessments will be conducted at baseline before the first tms/fmri session and again after the final tms/fmri session to assess symptom changes.

Eligibility criteria:
inclusion criteria: * 18 to 60 years old, inclusive * right-handed * currently experiencing a major depressive episode (mdd) * capacity to give informed consent and follow study procedures * command of english language to understand/ respond to written and verbal instructions exclusion criteria: * mri contraindications (i.e., metal in body, claustrophobia, etc.) * tms contraindications (i.e., seizure disorder) * diagnosis of exclusionary psychiatric disorder (i.e., schizophrenia, bipolar) * current use of psychiatric medication and unable/ willing to safely withdraw * refusal to abstain from alcohol or drugs for duration of study * medication use that reduces seizure threshold * medication that interferes with blood flow (i.e., opioids, antihypertensive) * known neurological disorder or significant disability that interferes with study procedures * woman who is pregnant or breastfeeding

Keywords: depression tms fmri
iv steroids versus steroids included in block for orthopedic lower limb surgery

Conditions: Lower Limb Injury

Summary: iv and included steroids have produced the same length of block prolongation in adults as if the steroid was given with the nerve block. clinically, this has not be noticed in children. the objective of this study is to examine this in young patients. the investigator will blindly give the steroid either in the iv or in the block solution (perineural). this is a prospective double blind study.

the subject has a 50/50 chance of receiving either cohort. after the subject is randomized to receive either steroid given iv or with the nerve block, the subject is anesthetized and the subject will receive either an iv injection of 5 cc steroids or placebo, and 20 cc local anesthetic plus placebo or steroid in the nerve block, the block will be placed under ultrasound to insure proper placement of block, the dose of steroid is based on weight, 0.1 - 0.15 mg/kg. the investigator will record the time of block and iv injection. the subjects will be called by the study pi after 24 hours to determine the time of duration and again at 48 hours if needed. this is a randomized, double blind study, neither the subject or the anesthesiologist giving the injection will know what is being given. the medications will be prepared and dispensed by the research pharmacist, a randomization chart will be obtained by the research pharmacist.

Eligibility criteria:
inclusion criteria: * scheduled to have a lower limb orthopedic surgical procedure. * scheduled to have a nerve block placed for post operative analgesia. * american society of anesthesiologist (asa) class i - iii. exclusion criteria: * not scheduled to have a nerve block placed for post operative analgesia.
magnetic resonance spectroscopy studies of cardiac muscle metabolism

Conditions: Heart Failure, Congestive

Summary: the metabolism of the heart provides the chemical energy needed to fuel ongoing normal heart contraction. magnetic resonance spectroscopy is a technique used in a mri scanner that can be used to measure and study heart metabolism directly but without blood sampling or obtaining tissue biopsies. one of the hypotheses this study aims to investigate is whether energy metabolism is reduced in heart failure and whether that contributes to the poor heart function.

this study uses magnetic resonance (mr) spectroscopy to study heart metabolism and function in normal subjects and patients with left ventricular hypertrophy, dilated cardiomyopathy, and those with coronary artery disease.

Eligibility criteria:
inclusion criteria: * age \> 18 years * healthy subjects: no history of heart disease * dilated cardiomyopathy: history of heart failure, ejection fraction (ef) \<40% * left ventricular hypertrophy: wall thickness \>1.2cm * coronary artery disease: \>50% coronary lesion or positive stress test exclusion criteria: * contraindication to mri
comparison of autologous quadriceps and hamstring tendon grafts in anterior cruciate ligament reconstruction

Conditions: Anterior Cruciate Ligament Injuries; Athletic Injuries; Tendon Graft; Complications

Summary: with the recent technological advancements, the use of the quadriceps tendon with an all-inside technique has come to the forefront, and large-scale research has focused especially on quadriceps tendon grafts. clinical study results have reported that the outcomes are similar to those of patellar tendon grafts and either equivalent or superior to hamstring tendon grafts. the aim of this study is the prospective comparison of the clinical and radiological outcomes of patients who underwent anterior cruciate ligament (acl) reconstruction with autologous hamstring and quadriceps tendon grafts.


Eligibility criteria:
inclusion criteria: * elite athletes * amateur athletes * anterior cruciate ligament injury exclusion criteria: * revision surgery * another ligament injury ( medial collateral ligament, lateral collateral ligament, etc.. ) * \> grade-2 cartilage injury * having previously undergone surgery on the same knee * \< 18 years age

Keywords: anterior cruciate ligament reconstruction hamstring tendons athletic injuries
a trial of a multimodal lifestyle intervention to optimize survivorship after cancer

Conditions: Neoplasm Malignant

Summary: to examine the efficacy of a 10-week multimodal lifestyle program, versus waitlist control, on cardiorespiratory fitness capacity and body weight in survivors of cancer.


Eligibility criteria:
inclusion criteria: * ability to provide informed consent before any trial-related activities * history of any malignancy * completion of cancer-directed therapy (e.g., surgery, chemotherapy, and radiotherapy) prior to enrollment (patients receiving ongoing endocrine or targeted therapy are eligible to participate) * no evidence of residual or recurrent cancer under active treatment * age ≥18 years * body mass index (bmi) ≥30 kg/m2 or bmi ≥27 kg/m2 with one or more treated or untreated weight-related coexisting conditions * willing to be randomized * allow the collection and storage of biospecimens and data for future use exclusion criteria: * engaging in ≥3 purposeful exercise sessions per week, on average, over the past 12 weeks * significant purposeful weight loss (\>11 kg) within the past 12 weeks * current use of medications or devices for the purpose of weight loss * metabolic or bariatric surgery within the last year * cardiovascular, respiratory, or musculoskeletal disease that would prohibit participation in an exercise and weight loss program * currently pregnant, breastfeeding, or planning to become pregnant with the next 12 weeks * psychiatric disorders or conditions that would preclude participation in the study intervention * any other condition which, in the opinion of the investigator, may impede testing of the study hypothesis or make it unsafe to engage in the study
yellow pea fractions and short-term food intake, subjective appetite and glycemic response

Conditions: Obesity; Type II Diabetes Mellitus; Metabolic Syndrome

Summary: it is hypothesized that yellow pea protein and fiber will reduce short-term food intake, subjective appetite and glycemic response.

a within-subject, randomized study was conducted. each subject returned 5 times, 1 week apart, and received 1 of the 5 treatments per week. the 5 treatments were tomato soup with 10 or 20 g of isolated yellow pea fibre or protein, or a control soup with no added pea fractions. food intake was measured at an ad libitum pizza meal served 2 hours after treatment. satiety and blood glucose (via finger prick) were measured throughout the treatment period.

Eligibility criteria:
inclusion criteria: * male 20-30 years old healthy weight exclusion criteria: * smoking restrictive eating metabolic diseases breakfast skippers dieters

Keywords: obesity food intake regulation blood glucose regulation protein fiber pulses yellow peas
green tea combined with chemotherapy in the treatment of advanced non-small cell lung cancer

Conditions: Non-small Cell Lung Cancer

Summary: patients with non-small cell lung cancer who met the inclusion and exclusion criteria were screened and randomly divided into control group and experimental group. control group: chemotherapy plus water ,test group: chemotherapy plus green tea. primary endpoint: assessment of changes in quality of life (qol) after chemotherapy according to fact-l (4th edition). a clinically significant change in the quality of life of lung cancer was defined as a fact-l score change of ≥6 points from baseline, with \<6 points defined as no clinically significant changes;

patients with non-small cell lung cancer who met the inclusion and exclusion criteria were screened and randomly divided into control group and experimental group. control group: chemotherapy plus water (at least 3-5 cups per day, 100-120ml per cup), test group: chemotherapy plus green tea (patients drink tea from the beginning to the end of the test, patients drink moderately concentration of green tea 3-5 cups per day, 100-120ml per cup, and the monthly tea consumption is ≥100g. the tea concentration is defined that the amount of tea in the cup after boiling water is 50% or more which is "strong tea", 25% to 50% is "moderately concentrated tea", and less than 25% is "light tea"). the number of days of tea drinking by the patient is greater than or equal to 18 days per chemotherapy cycle.the quality of life of patients was assessed according to the lung cancer quality of life scale (fact-l (4th edition)) and the lung cancer symptom scale (lcss). pre-chemotherapy quality of life scores were used as baseline. the evaluation was performed once before each chemotherapy, and the final quality of life assessment was performed within 1-4 weeks after the end of the fourth cycle of chemotherapy. a total of 5 quality of life assessments were completed. if the patient's condition progresses during chemotherapy, the assessment endpoint is when the disease progresses. primary endpoint: assessment of changes in quality of life (qol) after chemotherapy according to fact-l (4th edition). a clinically significant change in the quality of life of lung cancer was defined as a fact-l score change of ≥6 points from baseline, with \<6 points defined as no clinically significant changes;

Eligibility criteria:
inclusion criteria: * patients with pathologically confirmed nsclc have evaluable lesions. * ecog ps：0-2分。 * unintentional liver and kidney and other organic diseases, no other primary malignant tumors. * patients with clinical stage iiib and iv who are scheduled for chemotherapy (first or second line). exclusion criteria: * patients who have long-term tea drinking habits (more than 4 cups of green tea per day). * patients who have used immunological checkpoint inhibitors for more than 50%. pregnant or lactating woman. * the investigator judges other conditions that may affect the clinical research and the judgment of the research results.

Keywords: non-small cell lung cancer， green tea, chemotherapy，qol