Kornimate/medical-research-clean huggingface dataset:
a simple clinical maneuver to reduce laparoscopy induced shoulder pain

Conditions: Shoulder Pain

Summary: a pulmonary recruitment maneuver at the end of surgery reduced shoulder pain as well as nausea and vomiting after laparoscopic surgery.

with irb approval and informed consent, 100 female asa 1 and 2 outpatients who were scheduled for elective gynecologic laparoscopic surgery were randomly allocated to either the current standard (control group) or to additional efforts to remove residual co2 at the end of surgery (intervention group; power analysis yielded 45 patients necessary per group). in the control group, co2 was removed by passive deflation of the abdominal cavity through the holes of the trocar. in the intervention group, co2 was removed by means of trendelenburg position (\> 30 degrees) with 5 manual pulmonary recruitment maneuvers. postoperative shoulder pain was assessed prior to discharge and 12, 24, 36 and 48 hours later using a visual analog scale (vas). in addition, positional characteristics of the shoulder pain and incidence of postdischarge nausea and vomiting (pdnv) were recorded 48 hours after surgery.

Eligibility criteria:
inclusion criteria: * female * age 15-65 * asa i-ii * scheduled for outpatient gynaecological procedure exclusion criteria: * previous laparatomy * patients requiring hospitalisation * procedure required conversion to laparatomy * 48h follow-up no feasible

Keywords: laparoscopic surgery shoulder pain pdnv anesthesia residual co2 postoperative pain female asa 1 and 2 outpatients who were scheduled for elective gynecologic laparoscopic surgery
the galway sea swimmers study

Conditions: Cardiovascular Diseases; Hypertension

Summary: cardiovascular disease (cvd) is the leading cause of death worldwide. hypertension is a well-established risk factor for the development of cvd. lifestyle modifications, including exercise, remain the cornerstone of blood pressure (bp)-lowering strategy. swimming has long been a popular recreational activity for exercise, and is recently gaining widespread recognition as an effective option in maintaining and improving cardiovascular health. previous studies that involved pool swimming as an intervention (versus no pool swimming) demonstrated favorable benefits of the former on bp reduction. however, no studies to date have specifically investigated the effect of cold-water sea swimming on bp. indeed, the naturally lower water temperature in the sea may engender a 'cold water immersion' experience in sea swimmers with subsequent stress physiology, which have been shown to exert unique effects on cardiovascular hemodynamics. this study primarily aims to determine the impact of cold-water sea swimming on bp in a group of habitual sea swimmers in galway who will be randomly assigned to either continue or stop swimming for 4-6 weeks. other objective and subjective health benefits to sea swimming will also be explored in this study. given the ubiquitous nature of this activity in the irish general public, particularly in galway, this study has potential from a public health perspective, and would add to the literature base pertaining to the benefits of sea swimming on cardiovascular health.

consenting participants will be randomly assigned, 1:1, to either continuation of sea swimming or discontinuation of sea swimming for 4-6 weeks, stratified by the type of swimmer (those who purely immerse in the water for a brief period of time versus those who actually swim \[i.e., exercise\] in the water) and use of blood pressure medication at the time of study commencement (yes or no), using a block size of four to maintain balance between intervention arms. in line with previous studies that assessed the impact of swimming intervention on bp, participants randomized to the swimming arm should pursue sea swimming 2 or more days/week.

Eligibility criteria:
inclusion criteria: * habitual swimmers (i.e., sea swimming at least 2 times/week for the past year) * 18 years of age or older * able to provide informed consent exclusion criteria: * underlying cardiac (e.g., self-reported heart failure) or pulmonary diseases (e.g., self-reported chronic obstructive pulmonary disease) * recent orthopedic procedures (e.g., joint replacement therapy) * severe disabling comorbidity * recent arm (both arms) or chest wall injury * pregnant or breast feeding

Keywords: cardiovascular diseases cardiac disease heart diseases hypertension blood pressure swimming exercise vascular stiffness pulse wave analysis health-related quality of life heart rate variability immersion
non-alcoholic fatty liver disease parametric pet (flipp) study

Conditions: Non-alcoholic Fatty Liver Disease (NAFLD); Non-alcoholic Steatohepatitis (NASH)

Summary: the goal of this study is to evaluate non-invasive imaging techniques for determining liver steatosis (fat), inflammation (abnormal tissue swelling), and fibrosis (abnormal tissue scarring).in addition, the study group will be using other test measures including personal demographics, laboratory blood test results, and imaging measurements to determine the severity of nafld (non-alcoholic fatty liver disease), nash (non-alcoholic steatohepatitis), inflammation, and fibrosis.

the study group proposes to evaluate the role of fluorodeoxyglucose (fdg) positron emission tomography (pet) in the determination of steatohepatitis and in combination with mri for detection, differentiation and quantitation of liver steatosis, steatohepatitis and fibrosis in correlation to liver biopsy. patient enrolled in this will already have had their liver biopsy or will be undergoing liver biopsy as a part of their clinical care as determined by their provider and will not be getting biopsies solely to be enrolled in the study. current treatment options for patients that liver biopsy is being performed are limited to lifestyle changes and vitamin e for patients without diabetes.

Eligibility criteria:
inclusion criteria: 1. patients \>18 years age 2. patients who had or will have a liver biopsy as standard of care for fatty liver disease and have risk factors for nash. liver biopsy needs to be within 6 months of planned imaging. 3. patients undergoing bariatric surgery and will have a liver biopsy as standard of care. 4. ability to provide informed consent. exclusion criteria: 1. history of alcohol abuse, chronic hepatitis b or c, or other chronic liver disease other than non-alcoholic fatty liver disease. 2. pregnant women 3. prisoners 4. claustrophobic to mri 5. allergic to fdg dye 6. patients who are unable to lie in the scanner for one hour
long-term (3 months) safety of femtosecond-laser assisted cataract surgery

Conditions: Cataract

Summary: this clinical study is a prospective, post-market-clinical-follow-up study to investigate the long-term (3 months) safety of femtosecond laser assisted cataract surgery as a study follow-up extension to the study #1304 titled as "a multi-centre, multi-surgeon, randomized, controlled, prospective, post-market-clinical-follow-up study to investigate the impact of cataract grade on the efficacy and safety of femtosecond-laser assisted lens fragmentation procedure".


Eligibility criteria:
only the patients who were successfully enrolled in study #1304 are eligible for this follow-up extension study.
the effect of postoperative eustachian milking maneuver on eustachian tube dysfunction

Conditions: Postoperative Middle Ear Pressure; Otalgia

Summary: this study will evaluate the effectiveness of this lymphatic drainage method in eliminating otalgia interruption due to eustachian dysfunction and reducing middle ear pressure, which occurs in the postoperative period after adenoidectomy and/or adenotonsillectomy.

the eustachian tube lies between the middle ear and the nasopharyngeal cavity and provides ventilation of the middle ear. the most important function of the eustachian tube is to balance the air pressure in the middle ear with atmospheric pressure. temporary eustachian dysfunction and ear fullness occur in the early postoperative period after adenoidectomy and/or adenotonsillectomy. this temporary eustachian dysfunction is considered to be caused by clots and edema in the nasopharynx after surgery. in addition, trauma to the eustachian tube during adenoidectomy performed by curettage also contributes. eustachian dysfunction may present at the post-operative period resulted in otalgia related to middle ear pressure in the pediatric patients undergoing adenoidectomy or adenotonsillectomy. in this case, the need for analgesic agents rises in the early postoperative operiod and beyond this stituation impairs the quality of the healing process. reducing middle ear pressure by ensuring the mobility of the eustachian tube with the eustachian milking maneuver, which is a lymphatic drainage method, may reduce the otalgia symptoms during the post-operative recovery period, thus reducing the use of analgesic agents and improving the quality of the healing process. the aim of this observational study is to investigate to what extent a eustachian therapy maneuver corrects the negative values in middle ear pressure in the postoperative period.

Eligibility criteria:
inclusion criteria: patients with asa 1 and 2 the parent will be able to perform eustachian milking manoeuvres exclusion criteria: tympanometric examination performed in the preoperative period revealed eustachian dysfunction craniofacial malformation

Keywords: eustachian milking maneuver analgesia eustachian dysfunction
fast stepping in stroke patients for fall prediction and prevention:control mechanisms and clinical implications

Conditions: Stroke

Summary: the purpose of this study was to compare the balance strategy, as well as center of pressure (cop) trajectory and parameters between healthy adults and patients with hemiplegia in response to slow- and fast-speed waist- pulling perturbations in forward, left, right, and backward directions.

the ability to quickly respond to external perturbations is an important capacity of stroke patients to maintain dynamic balance in activities of daily living. the purpose of this study was to compare the balance strategy, as well as center of pressure (cop) trajectory and parameters between healthy adults and patients with hemiplegia in response to slow- and fast-speed waist- pulling perturbations in forward, left, right, and backward directions.

Eligibility criteria:
inclusion criteria: healthy adults * age ang sex are correspond with the stroke subjects(between 40 and 75 years old) * being willing to accept one-year follow-up examination * being willing to sign an informed consent approved by the human subjects committee of the national taiwan university hospital stroke patients * between 40 and 75 years old * stroke confirmed by icd-10-cm (including i60, i61, i62, i63, i67, and i69) * first stroke with single side hemiplegia and received acute treatment at ntuh * being willing to sign an informed consent approved by the human subjects committee of the national taiwan university hospital * able to step forward, laterally and backward independently without assistive device excursion criteria: healthy adults * - having other neurological diseases, or moderate to severe neuromuscular or musculoskeletal disorders, or disorders from systematic diseases those would influence the belance or motor ability stroke patients * having unstable vital sign, unconsciousness, or obvious cognitive, perception, and language impairment, and couldn't communicate with the experimenters * having other neurological diseases, or moderate to severe neuromuscular or musculoskeletal or cardiovascular disorders, or disorders from systematic diseases other than stroke

Keywords: hemiplegia waist pulling perturbation reactive balance strategy trajectory of center of pressure parameters of center of pressure
prf treatment for patients with chronic lumbosacral radicular pain compared to conventional medical management

Conditions: Lumbosacral Radicular Syndrome

Summary: the purpose of the study is to evaluate the effect of prf treatment adjacent to the lumbar dorsal root ganglion (drg) of l5 or s1 in patients with a chronic lumbosacral radicular syndrome (lrs). prospective, single blinded, multicenter clinical trial.


Eligibility criteria:
inclusion criteria: * symptoms more than 3 months 18,48 * optimized conventional medical management at least for 1 month * pain radiating into the leg, up to the hallux (big toe) (l5) or little toe (s1) * the pain in the leg dominates over a possible lumbalgia, the average pain in the leg measured 3 times a day, at predefined time points, over 4 consecutive days prior to inclusion should be more than 5 (nrs 10-point scale) 8 * pattern of radiation suggestive for l5 or s1 pathology 49,50 * one or more positive neurological tests of nerve root tension or neurological deficit 51 ; straight leg raising test (slrt), contralateral slrt, motor reaction during slrt and passive cervical flexion, motor reaction during passive cervical flexion while bending forward in standing position * capable of understanding the information relative to the treatment and procedure and willing to provide informed consent * capable of understanding and filling-out the questionnaires necessary for evaluation of the treatments * patients having undergone low back surgery like discectomy with or without laminectomy are allowed to participate in the study exclusion criteria: * patients younger than 18 years * malignant disorder or currently under treatment for a malignant disorder * previous lumbar fractures * proven myelum lesion or abnormalities in the central neurological structures * systemic or connective tissue diseases * diabetes mellitus type i * multiple sclerosis * coagulation disorders * pregnancy * conventional medical management less then 1 month * pain catastrophizing scale \> 45. when the patient has a higher score he/she will first be referred to a psychologist for consultation 52 * leg pain due to localized hip or knee pathology * patients with a pacemaker or neurostimulator * patients previously treated with rf or prf of the lumbar drg

Keywords: nrs gpe pain reduction quality of life
safety study of human anti-cytomegalovirus monoclonal antibody

Conditions: Cytomegalovirus Infections

Summary: the purpose of this study is to compare the safety profile in healthy adult volunteers of single or multiple intravenous administrations of tcn-202 as compared with placebo.

human cytomegalovirus (hcmv) disease remains an unmet medical need: in the us, the estimated prevalence of congenital hcmv infection is \~1% and is one of the leading causes of permanent hearing loss and neurological deficits in children. in immunocompromised individuals such as transplant recipients it can cause serious life-threatening disease and may significantly increase the risk of graft rejection. as existing therapies for hcmv can have serious side effects, there remains a medical need for safe and effective treatment of hcmv disease.

Eligibility criteria:
inclusion criteria: * healthy adult volunteers * normal lab tests exclusion criteria: * prior treatment with monoclonal antibody

Keywords: cytomegalovirus monoclonal antibody
combined prospective and retrospective post-market follow up of the 'bpk-s integration' uc as primary implant in the variant cocr

Conditions: Osteoarthritis, Knee; Joint Instability

Summary: patients who received a total knee endoprosthesis bpk-s integration between 2011 and 2013 will be invited to participate in this pmcf study provided sufficient source data documentation is available regarding preoperative, intraoperative and early postoperative follow-up assessments. only patients providing written informed consent prior to any study data collection can take part in the study. preoperative, intraoperative and early postoperative data (3 months, 1 year and 2 years after implantation) will be collected retrospectively. additional long-term follow-up of one visit (year 7 after implantation) will be documented prospectively. only parameters assessed in clinical standard care for follow-up (implant control) visits will be collected for this pmcf study. radiological assessment of the implanted prosthesis will only be conducted if medically indicated according to the investigator. no additional study related assessment will be performed. only anonymized data will be used in this observational study to protect patient privacy. no personally identifiable information will be collected.


Eligibility criteria:
inclusion criteria: * patients that received a total primary knee endoprosthesis bpk-s integration (co28cr6mo) between 2011 and 2013 * patients that agree to participate and give written informed consent to the anonymized retrospective and prospective data collection within the study exclusion criteria: no study specific exclusion criteria are defined for this pmcf study.
the short-term mbt project

Conditions: Borderline Personality Disorder

Summary: the study will evaluate the benefitial and harmful effects of short-term (20 weeks) compared to long-term (14 months) mentalization-based therapy for outpatients with subthreshold or diagnosed borderline personality disorder.

psychotherapy for borderline personality disorder is often lengthy and resource-intensive. mentalization-based therapy is an example of an evidence-based treatment that currently has empirical support as an 18-months outpatient program for borderline personality disorder. however, this duration is rarely available, and the long and costly treatment combined with a highly prevalent disorder result in insufficient access to evidence-based care. the trial is an investigator-initiated, single-centre, assessor-blinded, randomized clinical superiority trial of short-term (20 weeks) compared to long-term (14 months) outpatient mentalization-based therapy for borderline personality disorder or subthreshold borderline personality disorder. participants will be recruited from the outpatient clinic for personality disorders at stolpegaard psychotherapy centre, mental health services, capital region of denmark. participants will be assessed at trial intake using the mini international neuropsychiatric interview and the structured clinical interview for dsm-5 personality disorders. participants will be included if they meet a minimum of four dsm-5 criteria for borderline personality disorder. participants will be assessed blind to treatment allocation at baseline, and at 8, 16, and 24 months after randomization. the primary outcome is severity of borderline symptomatology assessed using the zanarini rating scale for borderline personality disorder interview. secondary outcomes include self-harm incidents, functional impairment (work and social adjustment scale), quality of life (short-form health survey), and global functioning (global assessment of functioning scale). psychiatric symptoms (symptom checklist 90) will be included as an exploratory outcome. measures of personality functioning, attachment, group alliance, borderline symptoms and mentalization skills will be included as predictor and mediator variables.

Eligibility criteria:
inclusion criteria exclusive to the outpatient clinic * age \>18 years * personality disorder(s) considered to be primary diagnosis/diagnoses inclusion criteria exclusive to the trial: * a minimum of four dsm-5 criteria for borderline personality disorder * written informed consent exclusion criteria exclusive to the outpatient clinic: * possibility of a learning disability (iq\<75) * a diagnosis of schizotypal personality disorder or antisocial personality disorder * presence of a comorbid psychiatric disorder that requires specialist treatment elsewhere * current (past 2 months) substance dependance including alcohol * concurrent psychotherapeutic treatment outside the clinic exclusion criteria exclusive to the trial: - lack of informed consent

Keywords: mentalization-based therapy borderline personality disorder randomized clinical trial psychotherapy research treatment intensity
effect of palm sugar on blood glucose concentrations

Conditions: Healthy Adults

Summary: the purpose of this study is to determine by how much, the ingestion of palm sugar increases blood glucose concentrations and what the corresponding glycaemic index is. the investigators estimate that the glycaemic index will be 68 (equal to that of sucrose).


Eligibility criteria:
inclusion criteria: * healthy: as judged by the participant; * age: 18 to 35. exclusion criteria: * pregnant or lactating females * presence of a chronic disease such as diabetes, illness, dysmetabolic syndrome * 18.5 \< bmi \< 25 * allergy or intolerance to palms or coconuts * weight loss or gain of more then 5 kg in the last two months * fasting blood glucose levels \<100 mg/dl or 5.6 mmol/l * smokers * use of medications other then birth control * previous problems with blood sampling

Keywords: glycaemic index arenga pinnata sugar palm sugar diabetes
multicenter observational study to validate a new index for sleep fragmentation analysis: sleep diversity index (sdi)

Conditions: Sleep Fragmentation

Summary: the investigators want to validate the sleep diversity index as a diagnosis tool of sleep fragmentation on 405 patients who will perform a polysomnography under spontaneous breathing.

sleep fragmentation is one of the main problems of sleep disorders especially in respiratory failure. during this last decade, several indicators of sleep fragmentation were introduced but none of them seems to take into account the succession of sleep stages. to tackle with this problem, the investigators used the shannon entropy index for modelling sleep stages diversity from an hypnogram and for assessing more accurately sleep quality by quantifying its fragmentation. the investigators developed a new tool we called sleep diversity index (sdi). in a retrospective study, the investigators calculated sleep diversity index for 55 healthy subjects and 56 patients with suspected sleep apnea syndrom. using the receiver operating characteristic (roc) curves the threshold of fragmentation was determined at 20%. if sdi is lower than 20%, then sleep is considered as non-fragmented and otherwise, sleep is considered as fragmented. to validate our sdi it is necessary to compare this diagnosis tool to a "gold standard" based on the clinician diagnosis and a mathematical diagnosis index created from objective criteria of polysomnography. the investigators propose a multicenter study to validate the sdi as a diagnosis tool of sleep fragmentation.

Eligibility criteria:
inclusion criteria: * spontaneous polysomnography exclusion criteria: * insomnia * patients with psychoactive drug having an important effect on sleep
an observational study of coronary microvascular disease of china

Conditions: Coronary Microvascular Disease

Summary: non-obstructive coronary heart disease refers to patients with angina pectoris without significant narrowing of the epicardial vessels. coronary microvascular disease(cmd) is a kind of non-obstructive coronary heart disease, and its clinical detection rate is increasing, seriously affecting the quality of life of patients, and increasing the risk of cardiovascular adverse events, but its mechanism has not been fully understood. this study will prospectively collect patients who meet the diagnosis of cmd, observe the development and outcome of the disease, and explore its occurrence and development mechanism.


Eligibility criteria:
inclusion criteria: 1. angina symptoms 2. objective evidence of myocardial ischemia 3. coronary angiography was normal,irregular tube wall, or stenosis \<50% exclusion criteria: 1. people under the age of 18 2. non-cardiogenic chest pain and other heart conditions such as variant angina, cardiomyopathy, myocarditis or valvular heart disease