Kornimate/medical-research-clean huggingface dataset:
evaluation of global smart drinking goals initiative

Conditions: Binge Drinking, Underage Drinking, Drinking and Driving, Alcohol-Related Harms

Summary: this study will evaluate effects of a multi-component, population-level intervention on alcohol use and related harms in six intervention cities relative to six matched comparison cities. intervention components include screening and brief interventions by health providers, other evidence-based interventions (e.g., enforcement of drink-driving or underage drinking laws), and novel or partially tested interventions that warrant further evaluation. key outcomes of interest include alcohol-related harms such as alcohol-related motor vehicle crashes and fatalities, heavy/binge drinking, underage drinking, and drinking and driving.

this study will evaluate effects of a multi-component, population-level intervention on alcohol use and related harms in six intervention cities relative to six matched comparison cities. the trial is expected to expand to nine intervention and nine comparison cities in 2018. intervention components include screening and brief interventions by health providers, other evidence-based interventions (e.g., enforcement of drink-driving or underage drinking laws), and novel or partially tested interventions that warrant further evaluation. key outcomes of interest include alcohol-related harms such as alcohol-related motor vehicle crashes and fatalities, heavy/binge drinking, underage drinking, and drinking and driving. multiple years of pre- and post-intervention survey data will be collected from cross-sectional samples of adults and youth in each city to assess intervention effects on harmful alcohol use. multiple years of archival data will also be collected from each city to assess intervention effects on alcohol-related harms such as motor vehicle crashes and fatalities, violence and unintentional injuries. multi-level analyses will be conducted with data for the total sample of 18 cities and for each pair of cities to determine whether the overall goal of reducing harmful alcohol use by at least 10% is achieved.

Eligibility criteria:
inclusion criteria: * at least 12 years old * parental consent is be required if under 18 years old exclusion criteria: * institutionalized individuals
patient anxiety associated with lymphedema surveillance method

Conditions: Anxiety

Summary: we propose to study the impact of bia screening on anxiety and primary prevention strategies for lymphedema development among patients with recent surgery for breast cancer. currently, professional societies recommend scheduled follow-up visits to screen for lymphedema after recovery from breast cancer (e.g., 6-week, 3-month, 6-month visits with a certified lymphedema therapist). screening involves a discussion of lymphedema symptoms and risk reduction strategies, measurement of the affected limb with a tape measure, and physical inspection for physical changes consistent with lymphedema. in the proposed study, patients will be randomly assigned to the addition of bia screening vs. usual care. at each screening visit, all patients will be assessed for their current lymphedema risk behaviors, as outlined by the national lymphedema network (7). to evaluate anxiety levels, all patients will be asked to fill out the beck anxiety inventory, a validated screening tool used in prior studies of patients with breast cancer (8,9). this questionnaire will be administered at each follow-up lymphedema screening visit, and the baseline will be administered at the preoperative visit. for patients randomly assigned to bia screening, this involves the placement of adhesive electrodes on the each wrist and an ankle, followed by connection of the electrodes to the bia machine, which then uses a painless electrical impulse to measure impedance of flow and thus asymmetry in the extracellular lymphedema volume between the 2 upper limbs (6,10). statistical analysis will involve comparison of lymphedema risk behaviors and anxiety levels between those patients with vs. without bia screening.


Eligibility criteria:
inclusion criteria: * women recently diagnosed with breast cancer age 18 and older exclusion criteria: - those women with a pacemaker

Keywords: lymphedema
clinical predictors of apnea-hypopnea during propofol sedation

Conditions: Sleep Apnea

Summary: to relate two different predictive values of sleep apnea: the stop score (snoring while sleeping, daytime tiredness, observed breathing stoppages, and high blood pressure) and the estimated respiratory disturbance index (erdi) with the occurrence of apnea-hypopnea during propofol sedation,thirty four middle-aged male patients who underwent urologic surgery under spinal anaesthesia will be enrolled. before surgery, patients will be asked to complete a stop-questionnaire. the erdi will be calculated using the modified mallampati's grade, tonsil grade, and the body mass index. after performing spinal anaesthesia, propofol will be infused and adjusted to bis 70-75. an apnealinktm, which measures airflow through a nasal cannula, will be then applied to estimate the level of apnea-hypopnea.

the investigators will evaluate correlation between stop scor and ahi(apnea hypopnea index) or erdi and ahi. after then the investigators will compare ahi severity between high risk group and low risk group subgrouped according to stop score or erdi.

Eligibility criteria:
inclusion criteria: * thirty four males who underwent spinal anaesthesia for transurethral resection of the bladder (turb) or prostate (turp) were enrolled in this studyinclusion criteria were american society of anaesthesiologists (asa) physical status of 1-2, and ages of more than 40 years. exclusion criteria: * patients with electrocardiographic or simple chest radiographic abnormalities or who had taken medication that could affect their sleep patterns were excluded.

Keywords: sedation, sleep apnea, propofol
predicting peripheral neuropathy of paclitaxel for gastric cancer

Conditions: Gastric Cancer; Chemotherapy-induced Peripheral Neuropathy; Paclitaxel; Ramucirumab

Summary: although advances in chemotherapy have improved the prognosis of gastric cancer patients, many patients still suffer from adverse events. therefore, it is necessary to establish personalized treatment by identifying patients at high risk for side effects. although paclitaxel-based therapy is the standard second-line treatment, peripheral neuropathy is a troublesome adverse event. the purpose of this study is to establish a liquid biopsy assay to predict paclitaxel-induced peripheral neuropathy in gastric cancer patients.

paclitaxel-based therapy is the standard second-line treatment for gastric cancer patients, but approximately 30-40% of patients develop peripheral neuropathy that interferes with daily life, and about 10% develop severe grade 3 peripheral neuropathy. particularly severe side effects can cause patients to lose strength, forcing them to discontinue treatment, and thus losing the opportunity to receive other treatments that were originally expected to have a therapeutic effect. this study aims to predict peripheral neuropathy in the side effects of second-line treatment (paclitaxel plus ramucirumab) in patients with gastric cancer using liquid biopsies (small rna). if patients at high risk for side effects can be predicted prior to treatment, high-risk patients can be offered drug reductions or other chemotherapy options. the aim of this study is to predict peripheral neuropathy of paclitaxel in second-line chemotherapy for gastric cancer by liquid biopsy.

Eligibility criteria:
inclusion criteria: 1. unresectable or recurrent gastric cancer (gc) histologically confirmed to be primary adenocarcinoma of the stomach. 2. age over 20 years. 3. eastern cooperative oncology group performance status score of 0-2. 4. written informed consent following full study information is provided to the patient. 5. progression or intolerance for first-line chemotherapy comprising fluorinated pyrimidine and platinum anticancer drugs (cisplatin or oxaliplatin) for advanced gc. 6. presence of evaluable lesions as confirmed using a computed tomography (ct) or magnetic resonance imaging. exclusion criteria: 1. patients with a life expectancy of shorter than 3 months 2. patients with severe complications (angina pectoris, myocardial infarction, or arrhythmia) or uncontrollable diabetes mellitus, blood hypertension, or bleeding tendency. 3. patients with a history of serious allergic reactions or serious drug allergy. 4. patients with a clinically relevant mental disorder that prohibits response to questionnaires. 5. patients for whom the attending physician considered that enrollment in the study is inappropriate.
study to evaluate induction chemotherapy using docetaxel, cisplatin and fluorouracil in concurrence with intensity-modulated radiotherapy for local recurrent nasopharyngeal carcinoma (npc)

Conditions: Nasopharyngeal Carcinoma

Summary: study objective: primary 1. to evaluate the complete response (cr) rate with induction chemotherapy using docetaxel, cisplatin and fluorouracil(tpf) followed by docetaxel plus cetuximab (tc) in concurrence with intensity-modulated radiotherapy (imrt). secondary 1. to determine the overall response rate. 2. to determine the locoregional and distant control rate 3. to determine the progression-free survival (pfs) 4. to determine the overall survival (os) 5. to determine the safety of the induction chemotherapy and concurrent chemoradiation plus cetuximab.


Eligibility criteria:
inclusion criteria: * recurrent t3n0-n1m0 npc (by ajcc/uicc 6th edition) and at least 1 year from the end of last primary course of radiotherapy * age \> 18 to \< 70 years * performance status: \< 1 by ecog system (appendix i) * adequate bone marrow \& renal function * patients having bilirubin =\ = 60ml/min * patients having wbc \>= 3x10e9/l, neutrophils 1.8x10e9/l, platelets \>= 100 x10e9/l,hemoglobin \>=10g/dl * signed written informed consent * patients must have at least one measurable lesion exclusion criteria: * use of investigational agent within the past 28 days * pre-treatment with an anti-egfr drug * severe cardiac disease such as heart failure, coronary artery disease or myocardial infarction within the last 12 months * history of severe pulmonary diseases * active infection or other systemic disease under poor control * uncontrolled chronic neuropathy * know grade 3 or 4 allergic reaction to any of the components of the treatment * estimated life expectancy is less than 3 months * pregnancy or breast feeding

Keywords: induction chemotherapy docetaxel cisplatin fluorouracil cetuximab intensity-modulated radiotherapy
a randomized, double-blind clinical investigation to evaluate the use of the relievion™ device in treating migraine.

Conditions: Migraine

Summary: this study will evaluate the clinical performance and safety of a self-administered abortive treatment for migraine headache using combined occipital and supraorbital transcutaneous nerve stimulator (neurolief device, relievion™).


Eligibility criteria:
inclusion criteria: * history of episodic or chronic migraine with or without aura meeting the diagnostic criteria listed in ichd-iii (international classification of headache disorders) beta (2013) section 1, migraine, with the exception of ''complicated migraine'' (i.e., hemiplegic migraine, basilar-type migraine, ophthalmoplegic migraine, migrainous infarction). * capable of cooperating with the study protocol and to sign an informed consent. exclusion criteria: * patients having received botox treatment in the head region in the prior 4 months. * patients having received supraorbital or occipital nerve blocks in the prior 4 months. * history of medication overuse headache. * patients using opioid medication. * allodynia: intolerance to supraorbital and/or occipital neurostimulation (allodynia) that makes the treatment not applicable (the patients will be excluded if they are unable to tolerate the first 3 minutes of neurostimulation). * implanted metal or electrical devices in the head (not including dental implants). * patient having had a previous experience with the relievion™ device. * patients who have concomitant epilepsy. * history of neurosurgical interventions. * patients with implanted neurostimulators, surgical clips (above the shoulder line) or any medical pumps. * history of drug abuse or alcoholism. * participation in current clinical study or participated in a clinical study within 3 months prior to this study. * skin lesion or inflammation at the region of the stimulating electrodes. * personality or somatoform disorder. * pregnancy or lactation. * women of reproductive age not using efficient contraceptive method. * history of cerebrovascular event. * subjects with recent brain or facial trauma (occurred less than 3 months prior to this study).
healthy early life moments in singapore

Conditions: Metabolic Disease; Mental Health Wellness 1; Lifestyle Risk Reduction; Maternal Obesity

Summary: this study aims to assess whether an integrated continuum of care from the preconception period, across maternity until the first 18 months of life, can promote maternal metabolic and mental health, as well as offspring health, among overweight and obese women.

maternal child health (mch) in singapore is currently entering a new phase to address the twin challenges; a burgeoning (i) metabolic and (ii) mental health challenge for singapore which have shown to have adverse effects on childbearing and child outcomes. to tackle these challenges, we are establishing a new model-of-care (moc) with a life-course approach at kk women's and children's hospital (kkh) through the healthy early life moments in singapore (helms) cohort. over the course of five years, helms will enroll 500 overweight or obese women aged 21-40 years planning for pregnancy, with an estimated 170 completing their pregnancies where they will be followed for another 18 months as a mother-child dyad. helms leverages on building a healthy mental model of life-course events through preconception to postpartum life. components of intervention will focus on preconception-pregnancy-postpartum care and lifestyle guidance on diet, physical activity, emotion and sleep, complemented by health nudges to promote sustainable change. various questionnaires and testing will be carried out at relevant time points. biosamples including blood, cord blood and stool will be collected. through the application of helms, there is potential to improve metabolic and mental health, break vicious transgenerational cycles of obesity transmission and promote virtuous life cycles of health in the population.

Eligibility criteria:
inclusion criteria: 1. women aged 21-40 years 2. bmi 25-40 kg/m2 3. intention to reside in singapore for the next 4 years 4. chinese, malay, indian or any combination of these 3 ethnic groups 5. planning to conceive within 1 year 6. able to understand english 7. able to provide written, informed consent exclusion criteria: 1. currently pregnant 2. known type 1 or type 2 diabetes 3. on any anticonvulsant medication in the past 1 month 4. on any oral steroid in the past 1 month (e.g. prednisolone, prednisone, deltasone, prelone, methyl prednisolone, medrol, hydrocortisone, cortef, dexamethasone, decadron) 5. on any oral, implanted contraception or intrauterine contraceptive device (iucd) in situ in the past 1 month 6. on any fertility medication (e.g. hormones injection, ivf treatments) other than clomiphene/ letrozole in the past 1 month 7. on hiv or hepatitis b or c medication in the past 1 month.

Keywords: obesity mental health lifestyle intervention
effect of peritoneal lavage with clindamycin-gentamicin solution & oncologic outcome

Conditions: Colorectal Tumors

Summary: antibiotic lavage reduces bacterial contamination and decreases ssi infection rate. ssi leads to an immunocompromised situation, leaving unattended the neoplasm. it has been described that ssi may result in a worse oncologic outcome.

antibiotics combined with lavage have demonstrated a reduction in the bacterial contamination and decreases ssi infection rate. ssi leads to an immunocompromised situation, as immunologic defense is focused on controlling the septic focus, leaving unattended the neoplasm. it has been described that ssi may result in a worse oncologic outcome. the aim of this study is to evaluate prospectively the effect of peritoneal lavage with clindamycin and gentamicin on the oncologic outcome of colorectal tumours.

Eligibility criteria:
inclusion criteria: * diagnosis of colon neoplasms * plans to undergo an elective surgery with curative aims exclusion criteria: * preoperative diagnosis of chronic renal failure (because of the risk of nephrotoxicity associated with intraperitoneal gentamicin absorption) * allergy to gentamicin or clindamycin.

Keywords: recurrence
treatment of tension headache using soft tissue techniques vs vagus stimulation techniques.

Conditions: Chronic Tension-Type Headache; Episodic Tension-Type Headache

Summary: a treatment based on manual therapy and vagus nerve stimulation is more effective than manual therapy only to reduce frequency, intensity and pressure pain threshold in patients with tension type headache.

participants will be randomly assigned to two groups: * experimental group, to which soft tissue techniques and vagus nerve stimulation techniques will be applied. * control group, to which only soft tissue techniques are applied. treatment will consist of four sessions, with an interval of seven days between them, for both study groups. each session with a duration of 20 minutes for both groups. in the control group, treatment using soft techniques will consist of the application of manual techniques that have already been shown to have some efficacy in other studies.

Eligibility criteria:
inclusion criteria: * patients diagnosed with episodic or chronic tension type headache exclusion criteria: * pregnant women * patients who have received in the previous 3 months some type of treatment for headache * recent history of syncope or seizures * heart / cardiovascular disease * electrical or neurostimulation devices * history of intracranial / carotid aneurysm or bleeding; brain tumors / lesions; significant head trauma. * change in prophylactic medication type or dose \<1 month before the intervention

Keywords: tension type headache manual therapy vagus nerve stimulation
the effect of binaural beats on pain perception and analgesic medication use in patients suffering from chronic pain

Conditions: Chronic Pain

Summary: this study evaluates the effect of binaural beats on pain perception and subsequent need for analgesic medication use in patients suffering from diseases causing chronic pain. all patients will receive two consecutive interventions: binaural beat signals embedded in relaxing music and placebo (relaxing music without the binaural beat component), in random order.

binaural beats consist of two artificially produced sound waves, differing in wave frequency, presented simultaneously and separately to each ear. the brain, following binaural beat processing, synchronizes to the frequency difference between the two waves. therefore, using a 5 hz frequency difference (theta rhythm), which promotes relaxation, we could alleviate pain perception and subsequent analgesic medication use. patients suffering from chronic pain will receive two consecutive interventions: binaural beat signals embedded in relaxing music and placebo (relaxing music without the binaural beat component), in random order. electroencephalogram (eeg) recordings will be used to confirm brain frequency synchronization, whereas pain severity scales and a diary recording analgesic medication use will be used to identify differences between intervention and placebo arms.

Eligibility criteria:
inclusion criteria: * chronic pain * regular analgesic medication use exclusion criteria: * malignant pain * headache as the cause of chronic pain * hearing disability * neuropsychiatric disease * previous experience with binaural beats
comparison of antibacterial efficacy of three final irrigants

Conditions: Endodontic Disease; Root Canal Infection

Summary: this study was conducted to determine the antibacterial affect of three different solutions used as final irrigant during endodontic therapy. the investigator's objective was to compare the antibacterial affect of relatively new final irrigant qmix with edta and qmix with edta+chx by evaluating the bacteriological status of the root canal before and after use of the final irrigant.

the aim of this clinical trial is to compare the antibacterial efficacy of qmix, to 17% edta+ chlorhexidine and 17% edta, used as final irrigants, during endodontic procedure. endodontic treatment was carried out on 90 necrosed teeth of patients under rubber dam isolation and strict sterilization protocol. the teeth were divided into three groups; a, b and c depending on the type of final irrigant to be used. the chemo-mechanical preparation of all the 90 samples was carried out using protaper universal (dentsply) file system, and 3% sodium hypochlorite. all the samples from each group were then irrigated according to the final rinse protocol (frp). group a was irrigated with qmix; group b with 17% edta + 2% chlorhexidine and group c (control group) 17% edta. three bacteriologic samples were taken during the procedure from each root canal under study in all three groups, using sterile paper points. sample a was collected after access cavity opening and negotiation of the canal but before chemo-mechanical preparation. sample b was taken after chemo-mechanical preparation but before the use of the final irrigant. sample c was collected after the use of final irrigation solution. the samples were collected with sterile paper points and were then transferred to microbiology laboratory in microtubes containing brain heart infusion (bhi) broth within 2 hours of sample collection for obtaining the colony forming unit (cfu) counts.

Eligibility criteria:
inclusion criteria: * teeth: * single rooted (one root canal) * necrosed teeth requiring root canal treatment. * teeth with mature apices * permanent dentition * mandibular \& maxillary * pai category 1 to 4 exclusion criteria: • teeth: * single rooted teeth with multiple canals * root canal treated * requiring elective endodontic therapy * with partial necrosis * fractured * having calcified and obliterated canals. * having root resorption * root canals which could not be negotiated to full working length with #10 k file * having severe periodontitis with exacerbating features (pai = 5) * having grade iii mobility * patients who took systemic antibiotics in past four weeks.

Keywords: final irrigation irrigation in endodontics qmix cfu colony forming unit mrs microbiological root canal sampling