Kornimate/medical-research-clean huggingface dataset:
mammography and breast arterial calcification: an information-sharing trial

Conditions: Mammography; Vascular Calcification

Summary: the purpose of this research study is to determine the potential benefits of adding information on patients' breast arterial calcification (bac) results to the standard results letter women receive after mammography. in addition to looking for potential breast cancer, research shows that mammograms can also detect the presence of calcifications within the breast arteries. those calcifications can be associated with coronary artery disease. right now, women are not routinely told whether or not they have bac; that is, it's not part of standard practice to communicate that information to patients. however, previous research has suggested that patients would like to be informed about their bac status more often. in this study, the team has two goals. first, the team wants to measure the rates of bac in a large, diverse group of 14,875 women. because most of the past research on bac has largely been focused on white mammography patients, the researchers feel it is important to see if the results are similar or different in a more racially and ethnically diverse sample. second, the study team wants to understand the effects of giving women information on their bac results as part of their standard post-mammography letter. specifically, the study team wants to see how sharing that information might affect women's healthcare choices and lifestyle. the research will include 1,888 women in this second part of the study, which will be the first in the literature to explore women's reactions to bac information. if research shows that women find the information useful, bac information may be given to women regularly in the future.


Eligibility criteria:
inclusion criteria * female * scheduled to undergo mammography at one of mount sinai's breast radiology clinics (e.g., dubin breast center, radiology associates) * age ≥ 40 years * read and speak english or spanish * ability to understand and the willingness to sign a written informed consent * willing to sign and date any applicable medical record release documents for the study exclusion criteria: * participants with known coronary artery disease (via self-report) * previous physician-diagnosed heart attack, stroke or tia, heart failure, angina or taking nitroglycerin, or atrial fibrillation (via self-report or review of emr) * inability to understand and comply with the instructions of the study due to the presence of cognitive or psychiatric conditions (such as dementia, psychosis, or mania), compromising ability to provide informed consent and/or follow study procedures * pregnant women

Keywords: mammography breast arterial calcification women's health preventive medicine behavioral medicine screening
oral glucose stimulation in normal-weight and obese volunteers

Conditions: Endocrine System Diseases

Summary: the objective of this study is to examine gastric emptying and satiety hormones after oral glucose stimulation in 2 different concentrations in normal-weight and obese patients.


Eligibility criteria:
inclusion criteria: * healthy normal weight subjects with a body-mass index of 19.0-24.5 or healthy obese subjects with a body-mass index of \> 30 * normal eating habits * age 18-40 years * stable body weight for at least three months exclusion criteria: * smoking * substance abuse * regular intake of medications (except for oral contraceptives) * medical or psychiatric illness * any abnormality detected during the screening procedure * history of gastrointestinal disorders * food allergies

Keywords: glucagon-like peptide-1 peptide tyrosine tyrosine ghrelin stomach small intestine gastric emptying
the cag bipolar the cag bipolar rct

Conditions: Bipolar Disorder

Summary: the cag bipolar study is a large-scale pragmatic randomized controlled trial aiming to investigate whether specialized and more centralized treatment (into a clinical academic group (cag)) improves lives and outcomes for patients with bipolar disorder (n= 1000 patients).

bipolar disorder is a complex illness with a complex treatment that differs during manic, depressed and remitted states, frequently leaving patients with decreased quality of life and impaired psychosocial function. traditionally, psychiatry has been sparsely subspecialized in denmark as well as internationally during the last four decades leaving patients in generalized psychiatric settings. at the same time, demands to clinical skills, research and education have increased, and it solutions have emerged as a possible way to optimize treatment. effects of organizational changes and digital health interventions are rarely investigated scientifically in health care services. this is a randomized controlled trial conducted in the entire mental health services, capital region of denmark including all psychiatric centers in the region. the cag bipolar study is a large-scale pragmatic randomized controlled trial aiming to investigate whether specialized and more centralized treatment (into a clinical academic group (cag)) improves lives and outcomes for patients with bipolar disorder (n= 1000 patients). findings from the study will have great impact on future organization and optimization of treatment within psychiatry in denmark as well as internationally.

Eligibility criteria:
inclusion criteria: * all patients with a main diagnosis of bipolar disorder in the five largest psychiatric centers in the mental health services, capital region of denmark (psychiatric center copenhagen, psychiatric center hillerød, psychiatric center amager, psychiatric center glostrup and psychiatric center ballerup) will be asked for participation exclusion criteria: * none
irinotecan, carboplatin and radiation therapy followed by bevacizumab in limited stage small cell lung cancer

Conditions: Lung Cancer

Summary: in this multicenter trial, we plan to evaluate the feasibility and toxicity of initial treatment with irinotecan/carboplatin/radiation therapy, followed by treatment with bevacizumab, in patients with limited stage small cell lung cancer.

upon determination of eligibility, all patients will be receive: * irinotecan + carboplatin + radiation therapy + bevacizumab patients will receive 4 courses of irinotecan/carboplatin. radiation therapy will begin concurrently with the third course of chemotherapy. the intervals between chemotherapy courses will be 21 days except for the interval between the third and fourth courses (during radiation therapy), which will be 28 days.

Eligibility criteria:
inclusion criteria: to be included in this study, you must meet the following criteria: * small cell lung cancer, confirmed by biopsy. * limited stage disease after standard evaluation. * able to perform activities of daily living without assistance. * no previous treatment with chemotherapy, radiation therapy, or biologics. * measurable or evaluable disease * adequate bone marrow, liver and kidney function * able to understand the nature of this study and give written consent. exclusion criteria: you cannot participate in this study if any of the following apply to you: * age \< 18 years * history of previous malignancies * women pregnant or lactating * history or physical exam evidence of central nervous system disease) * active infection requiring intravenous antibiotics * full-dose anticoagulation or thrombolytic therapy within 10 days * proteinuria. * serious nonhealing wound, ulcer, or bone fracture * evidence if bleeding diathesis or coagulopathy * history of heart attack within 6 months. * uncontrolled cardiovascular disease * peg or g-tube * history of other serious disease please note: there are additional inclusion/exclusion criteria. the study center will determine if you meet all of the criteria. if you do not qualify for the trial, study personnel will explain the reasons. if you do qualify, study personnel will explain the trial in detail and answer any questions you may have.
targeting the mechanisms underlying cutaneous neurofibroma formation in nf1: a clinical translational approach.

Conditions: Cutaneous Neurofibromas; Neurofibromatosis Type 1; Plexiform Neurofibromas

Summary: the purpose of the research study is intended to use specimens (such as tissue) and medical information in the laboratory of musculoskeletal oncology at the van andel research institute for laboratory research in grand rapids, michigan. small tissue samples of cutaneous neurofibromas will be collected as part of this research. the samples will help researchers learn more about cutaneous neurofibroma and help them better understand nf1. there are many different types of studies, both now and in the future, that can be done using the specimens the investigators receive. these include using the specimens and information to look for new ways to diagnose and treat neurofibromatosis type 1 (nf1). the specimens may be used to study how genes affect health and disease, or how genes affect the way a disease or condition responds to treatment. some of these studies may lead to new products, such as treatments or tests for diseases. through this study, the investigators hope to find better ways to understand and treat nf1 in the future.

skin tumors in neurofibromatosis type 1 (nf1) are very common and diminish quality of life. apart from surgery, very few treatment options exist. in comparison to other types of tumors in nf1, skin tumors receive less attention in the research world because they almost never turn into cancer. under the microscope, skin tumors and plexiform tumors look similar, however they do not share the same growth potential, nor do they appear at the same time during development. these differences suggest that skin tumors are driven by different factors than plexiform tumors. in this study the investigators will be harvesting cnfs from 3 groups of subjects in order to obtain a minimum of 18 tumors in three size categories: \ 1cm. these sizes were selected based on the variable natural history of cnf progression where incipient lesions (typically \ 1cm) lesions. interestingly, cnf growth tends to stall out at 3cm. the investigators plan to do experiments that identify which factors are important to cnf progression, and then find matching drugs that can shrink the tumors.

Eligibility criteria:
inclusion criteria: 1. any subject with an established diagnosis nf1 and cnfs. the diagnosis may be based on clinical criteria or genetic testing. 2. age \>18 years. exclusion criteria: 1. adults with diminished decision-making capacity with no defined legal guardian. 2. prisoners. 3. pregnant women. 3) breastfeeding mothers.

Keywords: nf1 cnf pnf skin tumors
picu admission lactate and central venous oxymetry study

Conditions: Shock

Summary: observational multicentre cohort study. children admitted to a dutch picu are studied for lactate levels and scvo2. children instrumented with arterial and central venous catheters are included within the first 12 hours after admittance.

rationale: hemodynamic therapy in children with circulatory insufficiency requires the use of hemodynamic monitoring parameters including parameters that reflect tissue/organ oxygenation and oxygen utilization. two parameters are readily available at the bedside that may reflect this: arterial lactate level and central venous oxygen saturation (scvo2). to date is it unknown if these parameters are useful in guiding treatment of critically ill children. also it is unknown how often lactate and scvo2 are abnormal in children admitted to a dutch picu or if they are related to each. objective: the objective of this study is to find the incidence of a raised lactate level and or a decreased scvo2, to study their mutual relation and to study the relation between lactate, scvo2 and outcome parameters in children admitted to a dutch picu. study design: observational cohort study study population: children admitted to a picu \<= 16 years intervention (if applicable): no intervention main study parameters/endpoints: arterial lactate level, central venous oxygen saturation (scvo2), arterial blood gas analysis and general hemodynamic variables in the first 24 hours after admission. parameters for organ dysfunction, severity of illness and outcome parameters like length of picu stay. nature and extent of the burden and risks associated with participation, benefit and group relatedness: this is a strict observational design. no blood samples are taken for the purpose of this study. no intravascular catheters are inserted for the purpose of this study. no treatment strategy is associated with this study.

Eligibility criteria:
inclusion criteria: * al children admitted to a picu \<= 16 years equipped with an arterial and central venous catheter in situ at admission or inserted within \< 12 hours after admission to the picu exclusion criteria: * patients without an arterial or central venous catheter \> 12 hours after of admission * patients with a known underlying metabolic disorder causing an elevated lactate level * patients with asthma and therapy (nebulized or intravenous) with salbutamol. * patients with an intoxication causing elevated lactate levels * premature children (\<38 weeks ga) * patients on ecmo

Keywords: scvo2 venous oxymetry lactate children picu admission parameters of shock
prediction of peritoneal metastasis for gastric cancer based on radiomics

Conditions: Gastric Cancer; Peritoneal Metastases

Summary: peritoneal metastasis of gastric cancer is difficult to be detected in time, thus delaying treatment. based on the conventional ct images of gastric cancer, this study plans to develop, improve and validate an intelligent analysis system based on radiomics. by extracting and combining the radiomics features related to peritoneal metastasis of gastric cancer, the intelligent analysis system could predict the risk of peritoneal metastasis, and provide personalized decision suggestions for the treatment of gastric cancer.

peritoneal metastasis of gastric cancer is difficult to be detected in time, thus delaying treatment. based on the conventional ct images of gastric cancer, this study plans to develop, improve and validate an intelligent analysis system based on radiomics. by extracting and combining the radiomics features related to peritoneal metastasis of gastric cancer, the intelligent analysis system could predict the risk of peritoneal metastasis, and provide personalized decision suggestions for the treatment of gastric cancer.

Eligibility criteria:
inclusion criteria: * (1) diagnosed advanced gastric cancer (≥ct3) by endoscopy-biopsy pathology, combined with ct and/or endoscopic ultrasound; * (2) with both enhanced ct and laparoscopy; * (3) without typical peritoneal metastasis indications in ct (diffuse omental nodules or omental cake, large amount of ascites, obvious irregular thickening with high peritoneal enhancement); * (4) without other evidence of distant metastasis, and no stage iv features on ct. exclusion criteria: * (1) previous abdominal surgery; * (2) previous abdominal malignancies or inflammatory diseases; * (3) time intervals between ct and laparoscopy longer than 2 weeks; * (4) ct image artifacts that undermine peritoneal lesion assessment.

Keywords: artificial intelligence classification gastric cancer peritoneal metastases computed tomography radiomics
correlation between sagittal balance of the spine and psychopathological profile

Conditions: Kyphosis in Depressed or Anxious Patients; Lordosis in Patients With Manic

Summary: in this trial, the correlation between the psychopathological profile and sagittal balance unexplored to date spine will be studied. indeed, a number of patients who benefited from well-conducted surgical treatment, targeted and tailored to their pathology, respond poorly to it. the investigators wonder if there are biomechanical factors or factors of psychopathological order which might influence the effectiveness of treatment. this seems logical for the entire medical community, but it has never been demonstrated in a clinical trial.

the purpose of this study is to find a global diagnostic and standardized tool , easy to use, on psychopathological factors influencing the posture of the patients lombalgia so that in this will be used to use identify upstream surgery, the patients undergoing psychiatric treatment of mood rather than surgical treatment. and thus may economise a surgical operation and its complications and the related expenses.

Eligibility criteria:
inclusion criteria: * men and women aged 18 to 70 years · * spine surgery outpatients with or without low back pain with radicular ·- affiliated to a social security scheme, * having signed an informed consent and were informed of the results of the consultation prior to inclusion exclusion criteria: * patients having the major diseases of the spine: deformities (scoliosis, kyphosis), tumors, fractures, inflammatory and metabolic · * patients having a spinal surgery history · * patients difficult to inform ( emergency ward patients, patients with difficulties in oral comprehension)
clinicaly manifested reinfections with borrelia burgdorferi sensu lato

Conditions: Lyme Borreliosis

Summary: data on reinfections with b. burgdorferi sensu lato in humans are scarce; they are limited to case reports and a few small groups of patients, mostly from the usa and less frequently from europe. in these reports, the clinical manifestation of reinfection was usually erythema migrans and was most often documented after successful treatment of a previous infection (almost always erythema migrans). the clinical manifestations of lyme disease in reinfection appear to be similar to those of primary infection, but there are no studies on possible differences in serological or immunological responses. the current study has 3 primary objectives: * to determine the frequency of clinically detectable reinfections and to identify the circumstances under which they occur; * to determine possible differences between primary and reinfection in clinical presentation, disease course and outcome, and specific serum antibody response; * to determine the aetiology of clinically detectable reinfections by comparing borrelia isolates recovered from the skin of the same patient at primary and reinfection.

the current study will encompass all patients aged ≥18 years who were treated at the department of infectious diseases, umc ljubljana for proven, clinically well-defined lyme borreliosis in the period 1989 - 2023. organised data collection in patients with lyme borreliosis started in 1986 when we established an outpatient lyme borreliosis clinic and introduced uniform approaches to diagnosis, treatment and follow-up of the disease course, thus obtaining a database of high quality clinical and laboratory data in a large number of patients. the aims: 1. to determine the frequency of clinically detectable reinfections and to identify the circumstances under which they occur (in a cohort of \~15000 european patients with erythema migrans and \~1500 patients with early extradermal or late lyme disease). 2. to determine possible differences between primary and reinfection in clinical presentation, disease course and outcome, and specific serum antibody response (by comparing clinical findings and serological test results in \~1500 patients who were diagnosed with erythema migrans more than 1 time). 3. to determine the aetiology of clinically detectable reinfections by comparing borrelia isolates recovered from the skin of the same patient at primary and reinfection (\~100 patients and 200 isolates, respectively).

Eligibility criteria:
inclusion criteria: * diagnosis of definitive lyme borreliosis exclusion criteria: * /

Keywords: lyme borreliosis reinfection borrelia burgdorferi sensu lato
rta 408 ophthalmic suspension for the treatment of ocular inflammation and pain following ocular surgery

Conditions: Inflammation and Pain Following Ocular Surgery

Summary: this study assesses the efficacy and safety of two concentrations of rta 408 ophthalmic suspension in the treatment of patients who have inflammation and pain following ocular surgery.

following ophthalmic surgery, the current standard of care includes a topical ophthalmic corticosteroid or other anti-inflammatory agent to treat ocular inflammation and improve patient comfort. if left untreated, inflammation of the eye may result in further ocular complications including scarring, vision loss, or blindness. although the exact dosing regimen is physician-dependent, patients are typically prescribed a topical corticosteroid for a period of 2-4 weeks following surgery, being tapered over the course of delivery as the inflammation subsides. topical anti-inflammatory agents are usually administered multiple times per day, particularly in the early period following ophthalmic surgery. continuing efforts in drug development aim to identify alternatives to ophthalmic corticosteroid use, due to their well-known local and systemic negative side effects.

Eligibility criteria:
inclusion criteria: 1. be greater than or equal to 18 years of age of either sex or any race; 2. have undergone unilateral cataract extraction via phacoemulsification on the day prior to study enrollment/randomization; 3. have a grade of ≥2 in anterior chamber cell score on day after surgery (day 1); 4. have a potential post-operative pin-hole visual acuity (va) of greater than 1.0 logarithm of the minimum angle of resolution (logmar) in the operative eye and fellow eye as measured using an early treatment for diabetic retinopathy study (etdrs) chart; exclusion criteria: 1. have any intraocular inflammation present in the study eye during the screening slit lamp examination; 2. have a score greater than "0" on the ocular pain assessment at screening in the study eye; 3. have an immunosuppressive disease or an autoimmune disease that in the opinion of the investigator could affect the quality of the ocular surface; 4. have active or chronic/recurrent ocular or systemic disease that is uncontrolled and will likely affect wound healing; 5. have an intraocular pressure (iop) ≤ 5 mmhg in either eye; 6. require the use of a contact lens or a collagen shield within 72 hours of investigational drug treatment or during the study period in the study eye; be unwilling to discontinue use of contact lenses during study period in the study eye; 7. require use of non-diagnostic topical ophthalmic solutions (other than perioperative mydriatics, anesthetics and antiseptics, prophylactic antibiotics, lid scrubs for mild blepharitis, or artificial tears for the management of dry eye) in the study eye for the duration of the study;

Keywords: rta 408 ocular surgery cataract surgery ocular inflammation ocular pain eye inflammation omaveloxolone
p. gingivalis igg titer test for periodontitis

Conditions: Periodontitis

Summary: this study was performed to evaluate prospectively the diagnostic utility of a blood igg antibody titer test against periodontal pathogens.

background: periodontitis is a prevalent silent infectious disease worldwide, and affects lifestyle-related diseases such as diabetes. therefore, efficient screening of patients is essential for general health. this study was performed to evaluate prospectively the diagnostic utility of a blood igg antibody titer test against periodontal pathogens. methods: oral examination was performed and blood igg antibody titers against periodontal pathogens were measured by elisa, in 1387 subjects. the cut-off value of igg titer was determined in receiver operating characteristic curve analysis, and changes in periodontal clinical parameters and igg titers by periodontal treatment were evaluated. the relationships between igg titers and severity of periodontitis were analyzed.

Eligibility criteria:
inclusion criteria: * periodontal patients * adults exclusion criteria: * difficulty of communication * received periodontal therapy within 3 months * with other diseases, i.e., hypertension, diabetes (self reported)

Keywords: igg titer periodontopathic bacteria