Kornimate/medical-research-clean huggingface dataset:
cervical myelopathy in hip fracture patients

Conditions: Cervical Myelopathy; Hip Fractures

Summary: recent evidence has demonstrated a high rate of undiagnosed cervical myelopathy in patients presenting with hip fractures from a ground level fall. identification and treatment of cervical myelopathy can help prevent falls and future fragility fractures. the purpose of this study is to screen ground level fall hip fracture patients for cervical myelopathy using a history, physical exam, and then offer an mri if indicated.

cervical myelopathy is compression of the cervical spinal cord which causes many things, but a common and prominent symptom is poor coordination/balance. this has been shown in multiple high quality studies to increase a patient's risk of falls as well as fragility fractures (such as hip fractures). often, patients with hip fractures present with multiple falls of unknown origin. work up from an orthopedic perspective is rare, but our medicine colleagues spend a substantial amount of resources to identify a cause (carotid ultrasound, head ct, ekg, echo, labs, etc.). this is because hip fractures in the elderly come with a 10-30% risk of death at one year. preventing a fall that causes a hip fracture is very important, and we, as orthopedists, are well positioned to aid in that endeavor. 8 years ago a study was published in a prominent orthopedic journal looking at cervical myelopathy in hip fracture patients. with 28 hip fracture patients, they found an 18% rate of cervical myelopathy. this was diagnosed on history and physical exam. mris were offered but not obtained. to date, this is the only study on this subject. this study will be similar but will go a step further and obtain a cervical spine mri to complete the diagnosis of cervical myelopathy for these patients. this can help get them on the pathway for treatment and future fall prevention. how it will work: once a patient sustains a hip fracture and is admitted to either methodist hospital, iu north hospital, or eskenazi hospital, study team will screen the patient for inclusion and exclusion criteria via chart review. if criteria are met, the patient will be seen in the hospital by study team and the patient will be consented for the study. the study team will do a physical exam and take a history from the patient for research purposes, looking for signs/symptoms of cervical myelopathy. if it is determined the patient likely has cervical myelopathy, as standard of care, the patient will be offered an mri and possibly be referred to a surgeon.

Eligibility criteria:
inclusion criteria: * patient admitted to eskenazi, methodist, or iu north hospital for a hip fracture (femoral neck, intertrochanteric, subtrochanteric, or pertrochanteric fracture) that was caused by a ground level fall. exclusion criteria: * neurologic or cognitive disorder explaining the fall (dementia, parkinson's disease, delirium, etc.) * syncopal fall or fall caused by stroke or a heart condition

Keywords: hip fracture cervical myelopathy
combined effects of isometric wall squats and high intensity interval training on rate pressure product in normotensive and pre-hypertensive sedentary adults

Conditions: Pre Hypertension

Summary: hypertension is leading yet preventable risk factor for cardiovascular disease and all-cause mortality worldwide. prehypertension identifies those at high risk of developing htn, prompting intervention to prevent or delay the onset of the disease. high intensity interval training (hiit) is a time efficient mode of training with established benefits, while isometric wall squats (iws) also provide a range of proven benefits and advantages, but their combined effect on bp measures is yet to be determined.hence the objective of this study is to compare the effects of isometric wall squats along with high intensity interval training versus high intensity interval training alone on rate pressure product, sbp and dbp, heart rate and anthropometric measures in normotensive and pre-hypertensive sedentary adults

pre-hypertension is not a disease itself rather it categorizes those who are at the risk of developing hypertension in future. by targeting pre-hypertensive and normotensive individuals we are focusing on preventive measures, potentially reducing incidence of htn and cardiovascular conditions in future. if found effective, this study can help in providing training protocols while also decreasing the risk of hypertension in future.a total of 15 sessions of high intensity interval training alone in one group and combination of high intensity interval and isometric wall squat in other group, for thrice a week on alternative days for 5 consecutive weeks will be given.

Eligibility criteria:
inclusion criteria: * both male and female adults aged 18-45 years. * participants lying in low pa (inactive) category on basis of ipaq. * pre-hypertensive adults: * sbp- 120 mmhg or more and \<140 mmhg * dbp of 80 mmhg or more and \< 90 mmhg. * normotensive adults: sbp \< 120 mmhg and dbp \< 80 mmhg. exclusion criteria * diagnosed with any current infections. * subjects with any diagnosed cardiovascular or respiratory conditions. * subjects with diagnosed musculoskeletal or neurological conditions which hinder participation in physical activity program. * active smokers * those with any contraindication to exercise testing or training. * pregnant females
prediction of nec with urinary ifabp

Conditions: Prematurity; Necrotizing Enterocolitis

Summary: during the first four days of life, intestinal fatty acid binding protein (ifabp) is elevated in the urine of premature babies who go on to develop necrotizing enterocolitis (nec) days to weeks later. this study aims to determine whether the withholding of feedings in babies with an elevated urinary ifabp can reduce the incidence of nec.

necrotizing enterocolits (nec) occurs with an incidence of 3-7% in very low birth weight (\<1500g) infants and is associated with significant morbidity and mortality. earlier detection of a subclinical prodrome in nec might allow for the institution of measures that could prevent or attenuate the severity of disease. we have demonstrated that levels of urinary intestinal fatty acid binding protein (ifabpu), a sensitive and specific marker for intestinal mucosal injury, were elevated in the first 4 days of life in all infants who subsequently developed nec. we hypothesize that, in the context of an elevated ifabpu in the neonatal period, a significant proportion of nec cases could be averted by not initiating feedings. the proposed study will be a three-year prospective trial of ifabpu monitoring during the neonatal period in 220 infants of gestational age less than 33 weeks. urine will be collected in 12-hour aliquots over the first four days of life and the ifabpu will be measured. on the afternoon of day of life four, infants in whom ifabpu exceeded 1000 pg/ml at any time will be continued with no feedings, ifabpu will continue to be measured, and trophic, breast milk feedings will only be initiated after ifabpu has normalized for five days. infants with non-elevated ifabpu over the first four days of life will have feedings initiated on day of life four, in the absence of other contraindications. all subjects will have urine collected daily over their entire hospital stay for ifabpu assay. however, after the active study period (after feedings have been initiated) ifabpu findings will not be communicated to the physicians caring for the subjects, but will be evaluated retrospectively in order to better define the utility of ifabpu as a marker for impending nec later in newborn life. if ifabpu monitoring is shown to be effective in reducing the incidence of nec it would revolutionize the care of premature infants by providing physicians with a tool that would permit feeding decisions to be based directly upon the viability of the intestine, rather than intuition.

Eligibility criteria:
inclusion criteria: * gestational age less than 33 weeks * admission to loma linda university children's hospital nicu within 48 hours of life exclusion criteria: * anuria * congenital gastrointestinal anomaly

Keywords: prematurity necrotizing enterocolitis biomarkers intestinal fatty acid binding protein feeding
serum mif in acute kidney injury

Conditions: Acute Kidney Injury

Summary: acute kidney injury (aki) is a common complication in critical care patients. currently no parameters are available for early prognosis of aki. macrophage migration inhibitory factor (mif) has been associated with aki in clinical studies. the aim of this study is to evaluate the time course of mif concentrations in patients with aki.


Eligibility criteria:
exclusion criteria: * age \ 80 years * patients with chronic dialysis * patients with continuous hemodialysis, hemofiltration or hemodiafiltration within 4 weeks prior to the study * patients with an expected length of icu stay shorter than 3 days * patients with a low probability of surviving the first 2 days after icu admission * pregnancy and nursing
seinior:quality of life and breast cancer in older women

Conditions: Breast Cancer

Summary: background : breast cancer is a disease that occurs primarily in elderly women: 54057 of breast cancer occurred on women in 2008, 15.2% were between 75 and 84 years and 5.4% were over 85 years. elderly women cancers care exposes to several problems: the opportunity for screening, knowing that mammography is not recommended after 75 years old, and the level of treatment depending on the background and the existence of weaknesses. it should determine whether patients are in adequate physiological condition to tolerate classical and "complete" treatment or conversely in a precarious state with advanced fragility, justifying only lightened and adapted symptomatic treatment. purpose : the purpose of this research theme is to assess the quality of life of elderly patients who underwent mastectomy for breast cancer. the objectives are: * assess the determinants of acceptance and / or rejection of mastectomy based on personal background (level of fragility, self-image) and linked to cancer * assess the quality of life, 6 months later, of women who underwent or not mastectomy, and appreciate the determinants abstract : the total mastectomy allow, oncologically, a more valid treatment than a lumpectomy, in many cases of women suffering from a breast cancer, but its relevance and acceptability are poorly known. some think that an elderly woman, postmenopausal, is less concerned with her aesthetics and feminine attributes, which would allow her to accept easily the mastectomy. the research hypothesis is that the acceptability of mastectomy is not good in elderly women

primary outcome: better detection of comorbidity and geriatric syndromes in vulnerable patients better detection of a degradation of the quality of life at d0 (at diagnosis) secondary outcomes: better support for quality of life and psychological support after mastectomy (revaluation to 6 months) integration of patients in the geriatric sector and implementation of regular monitoring study design: prospective, multicenter

Eligibility criteria:
inclusion criteria: 1. elderly patients about or over 75 years 2. female 3. patients in whom a diagnosis of breast cancer with surgical indication for mastectomy with or without lymph node dissection is discussed 4. ability to understand and give freely consent 5. informed consent signed 6. patient affiliated to the social security or entitled exclusion criteria: 1. patients under 75 years 2. male 3. patients under legal protection
observational study of the differences in characteristics of the spontaneous electroencephalogram, derived from the left and right hemisphere in patients with unilateral intracranial tumor during routine anesthesia: comparison with a control group without intracranial pathology

Conditions: Intracranial Tumor

Summary: study of the influence of brain tumor on bilateral electroencephalogram (eeg) during anaesthesia.


Eligibility criteria:
inclusion criteria: * adult ≥ 18 - 80 years old * able to comprehend, sign, and date the written informed consent document to participate in the clinical trial * scheduled for "procedure" * asa class i, ii or iii as assigned by the anaesthesiologist exclusion criteria: * allergy or inability to tolerate "product" * body weight less than 70% or more than 130% of ideal body weight * pregnant or nursing females * participation in a clinical trial within the past 30 days * congenital mental disability or congenital anatomical brain abnormality * a medical history of cerebrovascular accident or thrombosis * a medical history of carotic artery occlusive pathology * a medical history of degenerative cerebral pathology (ms, dementia, als, para-or tetraplegia due to a traumatic disruption of the spinal cord) * a medical history of severe psychiatric pathology (schizophrenia, severe depression, alcoholism, drug abuse) mild depression evoked by coping with the diagnosis of cancer is not excluded * patients with a history of epileptic insults. patients receiving preventive anti-epileptic treatment due to the tumoral process are not excluded. * patients with low cardiac output conditions due to pre-existing cardiac pathology (cardiac insufficiency, valve pathology, dysrhythmia, myocardial infarction). patients presenting with stable coronary artery disease with a normal myocardial function are not excluded) * arterial hypertension is not an exclusion criteria, nor is the use of antihypertensive medication, except beta blockers for their potential interfering effects on spontaneous eeg.

Keywords: intracranial tumor patients
randomised placebo-controlled duloxetine-referenced study of efficacy and safety of 15 and 20 mg of vortioxetine (lu aa21004) in acute treatment of major depressive disorder in adults

Conditions: Major Depressive Disorder

Summary: the purpose of the study is to evaluate the efficacy, tolerability and the safety of two fixed doses of vortioxetine in the treatment of major depressive disorder.


Eligibility criteria:
inclusion criteria: * the patient has recurrent mdd as the primary diagnosis according to dsm-iv-tr™ criteria (classification code 296.3x) * the patient has a madrs total score \>=26 * the patient has a cgi-s score \>=4 * the patient has had the current episode of mde for \>3 months exclusion criteria: * any current anxiety psychiatric disorder as defined in the dsm-iv tr * current diagnosis or history of manic or hypomanic episode, schizophrenia or any other psychotic disorder, including major depression with psychotic features, mental retardation, organic mental disorders, or mental disorders due to a general medical condition as defined in the dsm-iv tr * current diagnosis or history of alcohol or other substance abuse or dependence (excluding nicotine or caffeine) as defined in the dsm-iv tr * use of any psychoactive medication 2 weeks prior to screening and during the study * the patient is at significant risk of suicide or has a score \>=5 on item 10 (suicidal thoughts) of the madrs, or has attempted suicide within 6 months prior to the screening visit other protocol-defined inclusion and exclusion criteria may apply.

Keywords: major depressive disorder placebo-controlled active reference multicenter study randomised study acute treatment
management of depression in primary care

Conditions: Depression

Summary: most people in sweden with mild to moderate depression are treated in primary care, but follow-up is unstructured, and we know little about whether structured, follow-up would affect the prognosis for depression and working life. the purpose of this study is to determine the effectiveness of regular, structured, patient-centered visits on mild to moderate depression.


Eligibility criteria:
inclusion criteria * age 18 years and up * attends a participating primary health care center in the region * diagnosis of mild/moderate depressive disorder (new episode) * no change in possible antidepressant maintenance therapy during the preceding 1 month * provided written informed consent exclusion criteria * antidepressant medication initiated or changed during the preceding 1 month * patient diagnosed with major depressive disorder (bdi-ii \>28) * patients diagnosed of severe mental psychiatric disorder (i.e. bipolar disorder, antisocial personality disorder, psychosis, substance use disorder or other serious mental disorder) * suicidal ideation or intentions * inability to speak and understand swedish language well enough to take part in the activities required in the study. * cognitive impairment that makes it impossible to take part in the activities required in the study * does not provide written informed consent to participation in the study

Keywords: depression intervention primary health care
diabetic retinopathy: effects of melatonin treatment on visual functions and circadian rhythm

Conditions: Diabetic Retinopathy; Melatonin; Circadian Dysrhythmia; Circadian Rhythm Sleep Disorder, Unspecified Type

Summary: this study evaluates the effect of melatonin 4 mg on circadian rhythm and visual function of patients with diabetes mellitus. half of the patients will receive melatonin (arm-1) and the other half will receive placebo (arm-2), both groups in 3 weeks. after a week of washout, the patients will cross over to the other treatment arm.


Eligibility criteria:
inclusion criteria: * diabetic patients * age range 40-75 years * participant should be legally competent exclusion criteria: * other known eye disease. * eye disease manifestation during ocular examination. * competing neurologic and systemic conditions affecting retina. * use of any drugs influencing pupillary light reflex and sleep pattern. * refractive error with need of \> 6 diopter lenses. * pregnancy * alcohol consumption during the trial * lack of cooperation * allergy to melatonin and/or preservatives in melatonin and placebo * reduced hepatic function * fluvoxamin intake due to drug interaction * consumption of alpha-1 and beta-1 adnergic antagoists. * alcohol consumption during treatment
comparing the quality of life of terminal ileitis patients with crohn's disease treated with anti-tnf or surgical resection

Conditions: Quality of Life

Summary: compare the quality of life at 6 months between 2 populations of patients followed for terminal ileitis of crohn's disease treated with anti-tnf or ileocecal resection.

two groups of patients suffering from crohn's terminal ileitis will be matched by sex, age (a2, a3), the time evolution of the disease, the length of the diseased ileal segment (less than 10 cm; 10 to 30; 30 to 50 cm) and the montreal classification (b1, b2). the medical treatment group will be chosen among patients receiving anti-tnf therapy for the first time. the surgical group are the patients operated on for the first time by means of ileocecal resection by laparoscopy or laparotomy without any severity criteria or perianal lesions and do not require prophylactic treatment of recurrence.

Eligibility criteria:
inclusion criteria: * isolated crohn's ileitis without history of bowel resection and never previously been treated with anti-tnf * men and woman over 18 years * patient with social security cover * reapproved indication during multidisciplinary meeting * patient able to receive clear information in written and oral * informed consent signed by the patient exclusion criteria: * prophylactic treatment of recurrence before endoscopic control at the 6th postoperative month. * contraindication to anti-tnf after the initial lap works. * the side effects of surgery or anti-tnf are not exclusion criteria.

Keywords: quality of life crohn's disease ileocecal resection anti tnf
observational study of the sleuth implantable ecg monitoring system

Conditions: Syncope; Presyncope; Fainting; Cardiac Arrhythmia

Summary: the purpose of this study is to obtain information on real-world device performance clinical assessments and clinical outcomes of patients receiving the sleuth implantable ecg monitoring system.


Eligibility criteria:
inclusion criteria: * patients with clinical syndromes or situations at increased risk of cardiac arrhythmias * patients who experience transient symptoms that may suggest a cardiac arrhythmia exclusion criteria: * patients that have had a myocardial infarction (mi) \< 30 days prior to implant

Keywords: ilr ecg monitoring cardiac arrhythmia syncope presyncope fainting
suboptimal weight loss after gastric bypass surgery

Conditions: Obesity, Morbid

Summary: bariatric surgery is the only long-term established treatment for morbid obesity. however, some patients experience suboptimal weight loss after surgery and/or experience a significant weight regain. unfortunately there are very few studies in this area and little is known about the causes for lack of success or the best approach to treat this group of patients. the main aim of this study is to compare the efficacy of two different lifestyle treatment programs in this group of patients: 1) hospital-based outpatient program or 2) an inpatient treatment program consisting of 3 - 3-week stays at a rehabilitation center over a 1-year period. secondary aim is to determine potential reasons for suboptimal weight loss after bariatric surgery.


Eligibility criteria:
inclusion criteria: * body mass index (bmi) \>40kg/m2, or bmi\>35kg/m2 with comorbidities * healthy volunteers with suboptimal weight loss * health with significant weight regain after roux-n-y gastric bypass, defined as failure to lose at least 40% excess weight loss by 12 months postoperatively. significant weight regain: regain of ≥15% of total weight lost after the first postoperative year. exclusion criteria: * pregnancy * enrollment in another obesity treatment * previous revisional bariatric surgery * planned bariatric surgery * past or ongoing drug or alcohol abuse * physical or mental impairment that interferes with the ability to comply to treatment * history of severe psychological disorder * history of severe eating disorder * current medication known to affect appetite or induce weight loss

Keywords: weight loss bariatric surgery gastric bypass health education nutrition therapy diet exercise cognitive therapy
sleep-disordered breathing in infants with myelomeningocele

Conditions: Sleep-disordered Breathing; Myelomeningocele

Summary: this study aims to determine whether the risk for sleep-disordered breathing in infants with myelomeningocele (a severe form of spina bifida) differs among those who underwent fetal vs. postnatal surgery, and to examine the link between sleep-disordered breathing and neurodevelopment.

myelomeningocele (mmc), the most severe form of spina bifida, is characterized by exposure of the spinal cord through a spinal defect. sleep-disordered breathing (sdb) is common in children with mmc and is a risk factor for sudden death. abnormal sleep physiology is likely multifactorial, related to mmc level, brainstem dysfunction, musculoskeletal factors, and pulmonary abnormalities. in infants, sdb may be treatable with oxygen, caffeine, or positive airway pressure. yet, sdb screening is not routine, even in centers with specialized mmc programs. evaluation of sleep in neonates who require intensive care is an emerging opportunity with potential for major impact on health and quality of life for affected children. as sdb and abnormal sleep are potentially treatable, early assessment and intervention could become an integral part of a multidisciplinary treatment strategy to optimize long-term medical and neurodevelopmental outcomes.

Eligibility criteria:
inclusion criteria: neonates with myelomeningocele who are cared for at a study center nicu are eligible to participate after myelomeningocele repair. exclusion criteria: * born at \<30 weeks gestation * congenital anomalies that would predispose to sleep-disordered breathing (e.g. micrognathia) * confirmed or suspected genetic syndromes that alter developmental outcomes

Keywords: polysomnogram development sleep apnea