Kornimate/medical-research-clean huggingface dataset:
latin-american von willebrand disease registry

Conditions: Von Willebrand Disease

Summary: establish a latin-american network of centers and professionals with the aim of: * to register vwd patients in retrospective/prospective study, using a database, available online, common to all * to register the bleeding history, the treatment and the events of vwd patients in the region * to investigate the influence of vwd on quality of life

von willebrand disease (vwd) is the most common autosomal bleeding disorder, mostly inherited as dominant trait. vwd is due to deficiency/abnormality of von willebrand factor (vwf). the prevalence of vwd is unknown, but estimated as 0.1% to 1% of the general population. although the autosomal inheritance pattern would suggest an equal distribution of male and female patients, the disease is diagnosed in more females because of female-specific hemostatic challenges: menses, ovulation, pregnancy and childbirth. diagnosis of vwd is made by assessing personal and family history of bleeding, physical examination and completed with specific laboratory tests. there is limited information on the epidemiology of vwd in developing countries. some countries in latin america have registries of severe disease that, although it is the rarest form, carries the highest costs for regional health systems. so that the prevalence of clinical symptoms and laboratory features of the disease as well as the management of the disease in latin america is unknown. the present project aims to establish a network of centers and professionals with the objective to register and investigate all patients with vwd in latin america, using a database available online common to all, to gain understanding about phenotype, genotype and management of vwd in the region.

Eligibility criteria:
inclusion criteria: * historically lowest vwf:ag and/or vwf:rco and/or vwf:cb \< 0.50 iu/ml and/or fviii:c \< 0.50 iu/ml * all types of vwd * all ages exclusion criteria: * patient without consent to participate
on probiotic, dental caries, and orthodontic patients

Conditions: Dental Caries

Summary: to investigate the short term effect of probiotic oil on plaque acidogenicity among orthodontic patients. shortage on testing the effect of probiotic on orthodontic patients can be seen on litterateurs making a gap of whether is product of help in preventing dental caries or not ?

to investigate the short term effect of probiotic oil on plaque acidogenicity among orthodontic patients and to investigate the effect of probiotics on mutan streptococci and lactobacilli in plaque and saliva. the null-hypothesis is that: the effect of probiotics would not differ from placebo-treated control group. this product might decrease the chance of getting caries but also cooperation and cost effectiveness should be considered

Eligibility criteria:
inclusion criteria: * subjects undergoing bimaxillary fixed orthodontic treatment * number of s. mutans counts (\>10.000 cfu/ml) * permanent dentition * 3-12 months into the treatment (study from sweden by andrea) * medically healthy * not taking any medication * ability to understand the nature of the study and sign the consent form exclusion criteria: * cleft lip and palate patients as well as handicapped and patients with mental impairments * systemic diseases or conditions that could interfere with our study (diabetes, immunosuppression diseases, pregnancy or ongoing therapy). * history of probiotics/anti-inflammatory drugs taken during the last 4 weeks prior to baseline examination * local or general antimicrobial substances taken during the last 4 prior weeks prior to baseline examination * habitual consumers of xylitol chewing gums * no active or untreated carious lesions and reported daily tooth brushing habit using fluoridated toothpaste
an australian study of mesenchymal stromal cells for crohn's disease

Conditions: Crohn Disease

Summary: despite the advent of newer biologic therapies such as infliximab for crohn's disease, a form of autoimmune inflammatory bowel disease, a proportion of patients are refractory to such therapy and require surgery. the hypothesis is that mesenchymal stromal cell therapy using third party human cultured cells will be safe and effective


Eligibility criteria:
inclusion criteria: * colonic or small bowel crohn's disease based on endoscopic appearances and histology * refractory to induction with infliximab or adalimumab; or have lost response to these agents; or have had side effects precluding their further use * where there has been loss of response to one of these agents, the other must be tried before being eligible * crohn's disease activity score (cdai) 250 or more. * c-reactive protein \>10mg/l * surgery must have been offered to the subject (if appropriate) and declined * signed informed consent exclusion criteria: * active sepsis, perforating disease. coexistent perianal fistulous disease is permitted, providing no co-existent infection within previous 4 weeks * chronic stricturing disease in isolation * coexistent cmv disease * prior history of malignancy * pregnant or unwilling to practice contraceptive therapy or breast feeding females * last biologic therapy must be greater than 4 weeks prior, must be on stable corticosteroid dose for 14 days prior, during therapy and for 14 days after therapy, must be on stable immunomodulator dose (eg, azathioprine) for 14 days prior, during therapy and for 14 days after.

Keywords: mesenchymal stromal cells ileitis colitis
clinical evaluation of acuvue® oasys® 1-day and acuvue® oasys®

Conditions: Refractive Error

Summary: the purpose of this study is to evaluate the performance of two commercially-available silicone hydrogel contact lenses in normal and low humidity environments after at least 7 days of wear.

after randomization to lens order, subjects attended study visits that included a 3 hour exposure to reduced humidity environment (20% relative humidity) and subsequent tear film assessments for each study lens.

Eligibility criteria:
inclusion criteria: * must sign an informed consent form; * adapted, current soft silicone hydrogel daily disposable contact lens wearer during the last 2 months; * prescription within power range of both study contact lenses, as stated in the protocol; * cylinder equal or lower than -0.75 diopter (d) in both eyes; * willing to wear lenses every day or at least a minimum of 5 days per week, 6 hours per day; * willing to discontinue artificial tears and rewetting drops on the days of study visits; * other protocol-specified inclusion criteria may apply. exclusion criteria: * ocular anterior segment infection, inflammation, abnormality, or active disease that would contraindicate contact lens wear; * use of systemic or ocular medications for which contact lens wear could be contraindicated as determined by the investigator; * monocular (only 1 eye with functional vision) or fit with only 1 lens; * history of herpetic keratitis, ocular surgery, or irregular cornea; * pregnant or lactating; * current ao1d or ao lens wearer; * other protocol-specified exclusion criteria may apply.
a study to evaluate the efficacy and safety of ad-218

Conditions: Mixed Dyslipidemia

Summary: the purpose of this study is to evaluate the efficacy and safety of ad-218

condition or disease : mixed dyslipidemia treatment drug : ad-218, ad-218a, placebo of ad-218, placebo of ad-218a

Eligibility criteria:
inclusion criteria: * a man or woman over 19 years old. * sign on icf prior to study participation exclusion criteria: * history of fibromyalgia, myopathy etc (ck ≥ 2 x uln) * other exclusions applied
fujifilm dbt plus s-view versus ffdm alone in the detection of breast cancer

Conditions: Breast Cancer

Summary: the purpose of this pilot is to provide credible performance estimate information in order to conduct a subsequent pivotal reader study.

this clinical research is a retrospective, pilot, multi-reader, multi-case (mrmc) study with an enriched sample of 100 breast screening or diagnostic cases which were selected from the library of mammograms collected under fujifilm protocol fmsu2013-004a (all subjects previously provided written informed consent agreeing their image data and supporting documentation could be used for future research and investigations). approximately 6 qualified radiologists will independently perform two reads on all (approximately 100) cases. each reader will read each case both as a ffdm (full field digital mammography) read, and a dbt (digital breast tomosynthesis) plus s-view (synthesized view) read on the aspire bellus ii workstation.

Eligibility criteria:
inclusion criteria: * female subjects participating in fmsu2013-004a protocol with known clinical status exclusion criteria: * female subjects that did not have known clinical status in fmsu2013-004a
aerosolisation during respiratory procedures

Conditions: Healthy; Respiratory Tract Infections; Lung Infection; Droplet Spread

Summary: currently, a major issue within respiratory medicine is undertaking procedures that generate aerosolisation with the concern of spreading infection, such as the sars-cov-2/covid-19 virus. it is anecdotally reported that lung function testing and positive airways pressure devices used in clinical practice are aerosol generating procedures however the data to support this is limited. with the advent of high-speed imaging systems that can capture and quantify particle size and velocity we aim to investigate the aerosol generation in routine non-invasive positive pressure respiratory procedures.


Eligibility criteria:
inclusion criteria: * age 18-80 years * healthy subjects with no active medical conditions or previous pneumothorax * cognitively and linguistically able to follow instructions given in english and provide informed consent exclusion criteria: * significant respiratory, cardiac or neurological conditions or previous pneumothorax * smoking history greater than 10 pack years * acute illness at the time of assessment * allergies to latex, metals or local anaesthetic agents
the hit-trap trial

Conditions: Heparin-Induced Thrombocytopenia

Summary: randomised, double blind trial in non-intensive care trauma patients comparing unfractionated heparin (ufh) or low-molecular-weight heparin (lmwh) in heparin-induced thrombocytopenia (hit).

this is a randomised, double blind trial including trauma patients with need for thrombosis prophylaxis with heparin. patients receive either unfractionated heparin (ufh) or low-molecular-weight heparin (lmwh). heparin-induced thrombocytopenia (hit) antibodies are measured on days 1 and 10. there are daily platelet counts. on discharge an ultrasound doppler of the lower extremities is performed to rule out deep vein thrombosis (dvt). three months after discharge every patient is answering a questionnaire about thromboembolic complications following discharge. the key questions of the study are whether the two heparins cause hit-antibodies in differing frequencies, and if yes, whether these differences lead to different clinical outcomes.

Eligibility criteria:
inclusion criteria: * trauma-surgical patient * consent given * minimum age 18 * expected inpatient period at least 7 days * need for thrombosis prophylaxis with heparin exclusion criteria: * intolerance of one of the study drugs * malignancy with life expectancy \< 3 months * pregnancy/lactation * drug or alcohol abuse * fibrinolytic therapy * need for extracorporal circulation (e.g. cardiopulm. bypass, hemodialysis) at study entry * participation in another clinical trial within 30 days prior to intended inclusion

Keywords: heparin-induced thrombocytopenia hit unfractionated heparin ufh low-molecular-weight heparin lmwh thrombosis prophylaxis hit-antibody
evaluation of stepping stones

Conditions: Teen Pregnancy Prevention

Summary: the goal of this randomized trial is to learn if the stepping stones (stst) intervention has a positive impact on the sexual health and relationship behaviors of sexually active youth between the ages of 12 and 22 years old who are at risk for or involved in the legal or child welfare systems. the primary research questions it aims to answer are: * three months after being offered the intervention, does stst impact youth's receipt of sexually transmitted infection testing in the past four months? * nine months after being offered the intervention, does stst impact youth's frequency of having vaginal and anal sex without condoms in the past four months? * nine months after being offered the intervention, does stst impact youth's perpetration of emotional abuse in the past four months? researchers will compare participants randomized to receive stst (treatment group) to participants randomized to receive a control condition that contains no sexual or reproductive health information (control group). participants randomized to the treatment group will be offered stst as an-person, individual-based intervention delivered over four sessions during a 6-8 week period. participants randomized to the control group will be offered a virtually delivered control condition.

this is an individual-level, randomized control trial to rigorously evaluate the impact of the stepping stones (stst) intervention. participant outcomes will be assessed using self-reported, individual-level data gathered using a structured questionnaire administered at three time points: baseline (enrollment); three months post-intervention (five months after baseline); and nine months post-intervention (eleven months after baseline).

Eligibility criteria:
inclusion criteria: * at risk for or involved in the legal or child welfare systems * has had vaginal or anal sex in the past 3 months * comfortable reading, speaking, and writing in english exclusion criteria: * currently trying to start a pregnancy * currently in jail or being detained in a facility
training of arms to reduce pain with peripheral venous catheter

Conditions: Pain; Cancer; Veins

Summary: female patients undergoing chemotherapy for breast cancer often experience pain and discomfort when a peripheral venous catheter is inserted. this randomized, controlled trial investigates whether there is a difference in the degree of pain during pvc insertion in patients who exercise their arms, and whether exercise improves vein status. participation involves: * everyone must have had their peripheral venous catheter (pvc) inserted at least five times in the drop-in, which is an outpatient clinic staffed by anesthesia nurses who are specialists in applying pvcs. * everyone will three times be asked to answer some questions in the drop-in, have their grip strength measured in both hands, and have the course of the veins in their arms clarified. * the training group must do arm training exercises daily for at least eight weeks (training equipment is provided) * ten participants will at the end of the project period be invited to participate in a telephone interview about experiences of vein status during a cancer treatment course.


Eligibility criteria:
inclusion criteria: * planned neoadjuvant or adjuvant chemotherapy via intravenous peripheral venous cannula placed under ultrasound guidance * pvc insertion is performed in the drop-in outpatient clinic, department of anesthesiology, vejle hospital, at least four times * the patient has provided written and orally informed consent * the patient must be cognitively well preserved and able to understand information exclusion criteria: * patients who cannot read and understand danish * patients \<18 years
persistent organic pollutants and mechanical discharge: limiting the impact of bariatric surgery through personalized adapted physical activity

Conditions: Obesity; Bariatric Surgery Candidate

Summary: for the most severe cases of obesity, recourse to bariatric surgery is the ultimate solution. although highly beneficial to individual health, this massive loss of body mass could also have negative effects on metabolism and neuromuscular function. unfortunately, these effects have been relatively little studied in the scientific literature, and are poorly taken into account in patient follow-up when bariatric surgery has been recommended. one of the adverse effects of bariatric surgery is the release into the bloodstream of persistent organic pollutants (pops) which, are not only persistent, but also bioaccumulative, toxic and mobile. the major problem is that these circulating pops are linked to a number of adverse side effects, including reproductive disorders, neurobehavioral alterations, metabolic disorders, gut microbiota alterations inflammatory changes and physiological alterations. pop neurotoxicity could also affect psychomotor abilities and neuromuscular function. in addition, the mechanical unloading (i.e., reduced mechanical stress on muscles) induced by loss of body mass, an effect targeted by bariatric surgery and largely beneficial to the health of individuals, could also alter neuromuscular function and potentially alter muscle architecture and contractile properties. unfortunately, no data are currently available in the scientific literature to confirm or refute these hypotheses. physical activity-based intervention strategies may be usefull to counteract the effects of mechanical unloading and the release of pops as suggested in scientific literature. however it is also possible to question which exercise modality should be preferred. our hypothesis is that eccentric muscle strengthening would better preserve muscle mass and neuromuscular function while limiting the risks associated with pops release, compared with an aerobic and a control group.


Eligibility criteria:
inclusion criteria: * adult patient (18-55 years) * patient scheduled for bariatric surgery * patient practicing a leisure-time physical activity \< 8 hours of moderate intensity per week or \< 4 hours of high intensity per week * presence of effective contraception (hormonal or mechanical) exclusion criteria: * patient already involved in another experimental study * pregnant (urine pregnancy test) or breast-feeding women * patient in a particular situation deemed incompatible with the study by the investigator * patients from outside the alpes-maritimes and var departments * patient having received antibiotic treatment during the 3 months preceding the first stool collection * presence of a contraindication to adapted physical activity * presence of a contraindication to neurostimulation
trial of comprehensive migraine intervention

Conditions: Migraine

Summary: despite the fact that more than 10% of americans suffer from migraine, this headache disorder is often not diagnosed and not appropriately treated. the goal of this proposal is to determine whether a migraine protocol designed for use in an emergency room can be used to deliver the headache care that many migraine patients never receive. this is a randomized trial. consecutive inadequately treated migraine patients will be randomized to typical care or to comprehensive care. those patients in the comprehensive care arm will receive the following intervention: 1) reinforcement of diagnosis, 2) an adaptable online educational intervention, reading material, and headache diaries, 3) two migraine specific medications and 4) expedited referral to a headache specialist, if needed. patients in the typical care arm will receive whatever intervention the emergency physician feels is most appropriate. headache surveys will be used toll if the protocol improves migraine-related pain and functional disability one month after the er visit.


Eligibility criteria:
inclusion criteria: * migraine, * baseline migraine related disability of mild or worse, * no current or past triptan use, * not satisfied with current headache care. exclusion criteria: * allergy or contraindication to study medications, * daily or near daily analgesic medication use.
reducing hemodialysis catheter use in prevalent hemodialysis patients

Conditions: Hemodialysis

Summary: to determine if a protocolized approach to converting hemodialysis central venous catheters (cvc) to arteriovenous fistulae will improve rates of functioning avf and decrease cvc use.

in order to receive dialysis, patients require repeated access to their bloodstream. this access can be either via a central venous catheter (cvc) or a surgically created arteriovenous fistula (avf) or graft (avg). this is a pilot randomized control trial of prevalent hemodialysis patients with a central venous catheter (cvc), to determine if a systematic approach using an algorithm protocol to convert the cvc to an avf (arteriovenous fistula) will improve rates of functioning avf and decrease cvc use. the algorithm (intervention group) will be compared to current practice (control group), a non-standardized approach at the discretion of the caring nephrologist and/or surgeon.

Eligibility criteria:
inclusion criteria: * \> 18 years of age * dialyzing with a cvc * receiving hemodialysis three times weekly for \> 3 months exclusion criteria: * awaiting peritoneal dialysis catheter insertion * scheduled living donor transplant * transient patients from out of province * expected transfer to satellite dialysis unit within 6 months * surgical plan for avf (i.e. scheduled date) * documented lack of suitable vasculature for avf * refusing avf

Keywords: central venous catheter arteriovenous fistula hemodialysis vascular access dialysis
lung volume recruitment combined with expiratory muscle strength training in als

Conditions: Amyotrophic Lateral Sclerosis

Summary: the purpose of this study is to investigate the effects of two treatment techniques called expiratory muscle strength training (emst) and lung volume recruitment (lvr) on breathing, swallowing, speech, and cough function in persons with mild to moderate als. half of the participants will do emst alone, and the other half of the participants will do emst and lvr.


Eligibility criteria:
inclusion criteria: * als defined as possible, laboratory-supported probable, probable, or definite by el escorial criteria * reduced maximal expiratory pressure (mep) compared to norms for age and sex * forced vital capacity (fvc) \> 65% predicted exclusion criteria: * inability to provide informed consent * relative contraindications to lvr, including known pneumothorax, active internal bleeding, unstable hypertension, unstable angina, emphysema, recent barotrauma, or fev1 (forced expiratory volume, trial 1)/fvc ratio \< 0.7. * use of emst or breath stacking \> 3 days/week within 12 weeks of screening * amyotrophic lateral sclerosis-cognitive behavioral scale (als-cbs) score predictive of dementia (≤ 10) * participation in another clinical trial of an intervention in als within 30 days of study enrollment or during study enrollment