Kornimate/medical-research-clean huggingface dataset:
project move: increasing physical activity among breast cancer survivors

Conditions: Cancer Prevention

Summary: the purpose of this research is to implement and evaluate the feasibility of project move, a program aimed to increase physical activity among breast cancer survivors through microgrants and financial incentives.

despite the physical and psychological health benefits associated with physical activity for breast cancer survivors, up to 70% of female breast survivors are not meeting minimum recommended physical activity guidelines. the purpose of this research was to develop, implement and assess the feasibility of project move, an innovative approach to increase physical activity among breast cancer survivors through the use of action grants, a combination of microgrants (small amounts of money awarded to groups of individuals to support a physical activity initiative) and financial incentives. twelve groups of 8-12 adult women who are breast cancer survivors (n=132) were recruited for the study via face-to-face meetings with breast cancer-related stakeholders, local print and radio media, social media, and pamphlets and posters at community organisations and medical clinics. each group submitted a microgrant application outlining their proposed physical activity initiative. successful applicants were determined by a grant review panel and informed of a financial incentive upon meeting their physical activity goals. primary (program feasibility) and secondary (physical activity, quality of life, motivation to exercise and social connection) outcome measures were evaluated using a mixed-methods approach including focus groups, self-reported questionnaires, semi-structured telephone interviews and objective physical activity measures. measures were collected at baseline, post-intervention (6 months) and 12-month follow-up. findings from this study were used to asses the implementation and feasibility of project move as a strategy for increasing physical activity among breast cancer survivors.

Eligibility criteria:
inclusion criteria: * female breast cancer survivors * 18+ years old, * residing in the okanagan region of british columbia, canada exclusion criteria: * no specific exclusion criteria
open label study of fostamatinib in the treatment of iga nephropathy

Conditions: IGA Nephropathy

Summary: phase 2, multi-center, open label extension study to evaluate 2 dose regimens of fostamatinib in approximately 25 subjects. the study will consist of 11 visits over 15 months.


Eligibility criteria:
inclusion criteria: * completed study c-938788-050, including having received a post-treatment renal biopsy, and having had a clinically meaningful response (i.e. decreased proteinuria or improved renal histology) * able and willing to give written informed consent exclusion criteria: * unresolved grade 2 or greater toxicity in study c-935788-050
caregiver implementation strategies field pre-test

Conditions: Attention Deficit Hyperactivity Disorder Symptoms

Summary: the purpose of this study is to field pre-test an implementation strategy resource package that aims to support caregivers in using behavioral interventions for children with hyperactive, inattentive, or impulsive behaviors. enrolled caregivers will be assigned to use the resource package with their children. the research team will collect quantitative and qualitative data regarding acceptability, appropriateness, and feasibility, in preparation for a randomized pilot study.

evidence-based interventions for children with or at-risk for attention-deficit/hyperactivity disorder (adhd) include antecedent- and consequence- based behavioral interventions in both the classroom and home settings as well as effective home-school communication approaches. schools are a promising setting in which to provide early intervention for mental health challenges and to increase access to mental health care. furthermore, stronger integration between home- and school- based interventions has the potential to meaningfully improve child outcomes. however, there are substantial implementation challenges to caregivers' use of these evidence-based interventions. this study aims to field pre-test an implementation strategy resource package to support caregivers in using evidence-based behavioral interventions for children with hyperactive, inattentive, or impulsive behaviors. after an initial iterative process of developing the resource package, enrolled caregivers will use the resource package with their children in a single-arm study, for the purpose of assessing initial implementation outcomes and making final adjustments to the resource package.

Eligibility criteria:
inclusion criteria: * grades k-5 * nominated for participation by a school staff member or parent/legal guardian * identified by that staff member or parent/legal guardian as displaying functional impairment from adhd symptoms, as measured by a score of a 3 or greater on the modified version of the impairment rating scale. exclusion criteria: * presents as in acute risk of harm to self or others, such that participation in the study is clinically inappropriate because the child warrants more intensive intervention * special education classification of 'intellectual disability' * students from families in which there is not a caregiver who speaks english will be excluded because the focus of this study is developing an english-language version of the resource package

Keywords: attention deficit hyperactivity disorder positive behavior management inattentive hyperactive impulsive
effect of vitamin d in burn patients

Conditions: Burn Surgery

Summary: the purpose of this study is to evaluate pre-operative vitamin d levels in patients with burn injuries and evaluate the effect of vitamin d on postoperative complications and duration of hospitalization.

vitamin d deficiency often occurs in burn patients, which may include longer hospitalization and respiratory and cardiac complications. the purpose of this study is to evaluate pre-operative vitamin d levels in patients with burn injuries and evaluate the effect of vitamin d on postoperative complications and duration of hospitalization.

Eligibility criteria:
inclusion criteria: * vitamin d \<30 ng/ml * patients undergoing burn surgery exclusion criteria: * age \< 18 years old * hypercalcemia * renal disease * cardiac disease ( ef\<40%, mi, angina) * respiratory disease (ards, pneumonia) * intubated patients * electrical burn
comparison of perennial and preseasonal subcutaneous immunotherapy

Conditions: Seasonal Allergic Rhinitis

Summary: specific immunotherapy, which involves the administration of allergic extracts to patients with symptoms of allergic disorder, is the leading therapeutical tool of modern allergology. according to the latest studies immunotherapy not only reduces symptoms' severity but also may modify the course of allergic disease by reducing the risk of new sensitisations and development of more advanced stages of the disease.it has been hypothesized basing on clinical observation that perennial immunotherapy is more effective and safer in comparison to preseasonal immunotherapy. the aim of the study was to compare the effect of perennial and preseasonal immunotherapy on rhinoconjunctivitis symptoms and safety of both treatments.


Eligibility criteria:
inclusion criteria: 1. ige-mediated seasonal allergic rhinitis with symptoms during the grass and rye pollens season (may, june, july); 2. symptoms of allergic rhinoconjunctivitis requiring medication during the last season 3. positive skin prick test to grass and rye pollens only with wheal at least as large as histamine control reaction and diameter \> 5mm; 4. for female patients effective contraception and negative pregnancy test results were necessary. exclusion criteria: 1. previous course of immunotherapy with grass and rye pollens extracts or allergens which are unknown during the last 5 years 2. fev1 \< 80% of predicted 3. uncontrolled bronchial asthma according to gina 4. non-allergic rhinoconjunctivitis 5. severe acute or chronic diseases, severe inflammatory diseases 6. autoimmune diseases, immunosuppression, neoplastic diseases 7. severe psychiatric and psychological disorders including alcohol or drug abuse 8. contraindication for application of adrenaline; 9. treatment with beta-blockers 10. pregnancy or lactation period 11. females patients seeking to become pregnant 12. low compliance.

Keywords: allergic rhinitis perennial immunotherapy preseasonal immunotherapy
patient controlled oral analgesia for postoperative pain management after total knee replacement

Conditions: Self-Administered Versus Nurse Administered Pain Medication.

Summary: patient centered care (pcc) is "an approach that consciously adopts the patient's perspective...about what matters" (gerteis, edgeman, levitan, walker, stokes, cleary, delbanco, 1993). experiencing pain is the most common concern of patients before surgery - even ahead of whether the surgery would improve their condition (apfelbaum, 2003). current standard of practice for post-operative pain management in most acute care hospitals today is intravenous patient controlled analgesia (iv pca). however, despite the fact that patients prefer iv pca because it affords them greater control and provides them with better pain relief (ballantyne, carr, deferranti, suarez, lau, chalmers, angelillo, mosteller, 1998 ; rawal, 2001), hospitals routinely take control of pain medications away from patients once they are switched to pain tablets. patients must then wait, in pain, for their nurse to bring them pain tablets. patient controlled oral analgesia (pcoa) has been utilitzed in several centers in the us and germany. preliminary evidence from the literature seems to indicate that the benefits of pcoa are similar to iv pca including increased patient satisfaction and better pain control (striebel, romer, kopf, schwagmeier ,1996; striebel, scheitza, philippi, behrens, toussaint, 1998). at the toronto western hospital, university health network, we have successfully implemented a pcoa program on two surgical units (orthopedics/rheumatology and spinal). the purpose of this study is to compare usual nurse administered oral analgesia to pcoa with respect to pain, patient satisfaction, and passive range of knee motion in postoperative total knee replacement patients.


Eligibility criteria:
inclusion criteria: * able to read and write english * post elective total knee replacement surgery (primary or revision) * already on iv pca * age 18-80 * able to tolerate oral medication * able to physically open a childproof vial independently (including the absence of any significant problems with manual power, dexterity or visual acuity) * able and willing to complete oral pca flowsheet exclusion criteria: * history of substance abuse * history of sleep apnea * episode(s) of confusion, disorientation during this admission * episode(s) of respiratory depression during this admission * history of major psychiatric disorder pregnancy
observational study to investigate the efficacy and safety of human insulin or insulin analogue treatments in type 2 diabetes subjects

Conditions: Diabetes; Diabetes Mellitus, Type 2

Summary: this study is conducted in asia. the aim of this observational study is to investigate the percentage of patients reaching the treatment target on blood glucose control after treatment with either human insulin or insulin analogues in type 2 diabetes subjects inadequately controlled with two or more oral antidiabetic drugs in china. further the safety profiles will be evaluated.


Eligibility criteria:
inclusion criteria: * after the investigator has taken the decision to use human insulin or insulin analogues to treat the subject, any type 2 diabetic previously inadequately controlled with two or more oads is eligible for the study * the selection of the subjects will be at the discretion of the individual investigator exclusion criteria: * known or suspected allergy to trial product(s) or related products * subjects who are unlikely to comply with protocol requirements, e.g. uncooperative attitude, inability to return for the final visit * subjects who previously enrolled in this study * females of childbearing potential who are pregnant, breast-feeding or intend to become pregnant or are not using adequate contraceptive methods * the receipt of any investigational product within 3 months prior to this trial
cognitive recovery after post stroke delirium (recover)

Conditions: Post Stroke Delirium; Cognitive Functioning After Stroke

Summary: recover is a proof-of-concept study on cognitive functioning following a longitudinal design with three measurements (during the acute- and post-acute phases of a stroke and a 3-month follow-up) and two equally-sized stroke patient groups: a post-stroke delirium(psd), and a non-psd group (control group). cognitive functioning will be assessed using a multi-component neuropsychological assessment and tasked-based functional mri (introducing a modified working memory task).


Eligibility criteria:
inclusion criteria: * age ≥ 60 years * ischemic stroke: stroke onset ≤ 96h, hospital admission ≤ 48h * nihss ≥ 1 * informed consent by patient or legal guardian exclusion criteria: * aphasia * pre-existing conditions such as dementia, psychiatric disorders (e.g., depression, schizophrenia) * mri contraindication such as certain metal implants * reduced consciousness, defined as glasgow coma scale (gcs) ≤ 8 * delirium onset before study enrollment
effect of peanut butter on gut and metabolic health

Conditions: Dysbiosis

Summary: the goal of this is parallel arm, randomized clinical trial is to learn and understand the effect of daily smooth peanut butter consumption on gut and metabolic health of children age 6-13. the main objectives are: primary objective: to determine the prebiotic effect of daily smooth peanut butter consumption for eight weeks on gut health, including microbiome-metabolome arrays, gut epithelial/barrier function, and gut transit time, in school-aged children. secondary objective(s) 1. to determine the effect of daily smooth peanut butter consumption for eight weeks on metabolic and inflammatory health markers, and measures of sleep quality in school-aged children. 2. to determine the potential mechanisms and feasibility of incorporating peanut butter into the diets of school-aged children as part of healthy, personalized nutrition. research intervention(s): researchers compare two groups to see if there really is an effect of daily smooth peanut butter intake on gut and metabolic health. the two groups are: 1. the 1st condition (pb) includes a normal diet supplemented daily with personalized portion of smooth pb, sandwiched between two plain unsalted saltine crackers. 2. the 2nd condition (ctl) includes a normal diet supplemented daily with an isocaloric amount of a nut-free, vegetable oil-based chocolate spread, sandwiched between two plain unsalted saltine crackers.


Eligibility criteria:
inclusion criteria: * enrolled in elementary or middle school (grades 1-8) * aged 6-13 years old * ability to speak and read in english exclusion criteria: * intake of antibiotics in the last 3 months * intake of pre/pro/postbiotics in the last 3 months * food allergy to study foods * any allergy to nuts or peanuts * any allergy to the isocaloric snack (chocolate or wheat) * regular consumption of nuts or peanuts greater than 2 servings / week * gastrointestinal disease (ulcerative colitis, crohn's disease, diverticulosis, peptic ulcers, small intestinal bacterial overgrowth, short bowel syndrome, irritable bowel syndrome, gastroesophageal reflux disease), neurological (multiple sclerosis, meningitis, recent stroke) or endocrine disorders (uncontrolled thyroid disorders, growth hormone disorders, adrenal gland disorders, uncontrolled diabetes - a1c \> 9%). * known to be pregnant (self-disclosed)

Keywords: microbiome gut nuts peanut butter metabolic health dysbiosis metagenomic sleep quality prebiotic children
an extension study to assess the safety, tolerability, efficacy, and treatment adherence of dapsone in acne vulgaris

Conditions: Acne Vulgaris

Summary: this study will assess the safety, tolerability, and efficacy of dapsone in subjects with acne vulgaris following 12 weeks of treatment.


Eligibility criteria:
inclusion criteria: * participation in allergan study 225678-004 exclusion criteria: * anticipates the need for surgery or hospitalization during the study
oxygenation and perfusion in patients with acute migraine attacks

Conditions: Migraine; Migraine With Aura; Migraine; Status

Summary: the aim of the study is to retrospectively evaluate brain perfusion and oxygenation in acute migraine attacks. magnetic resonance perfusion and susceptibility weighted imaging are the technics to measure perfusion and oxygenation respectively.

the aim of the study is to demonstrate a possible correlation between areas of hypoperfusion and prominent cortical veins during migraine attacks. these focal ares of altered vascular supply of the brain will be evaluated for correlation with topograhy of symptoms.

Eligibility criteria:
inclusion criteria: final clinical diagnosis of migraine exclusion criteria: brain tumors, seizures/epilepsy, confirmed cerebral infarct from cerebral atery occlusion, sinus vein thrombosis;
testing a brief mindful eating program

Conditions: Overeating; Overweight; Obesity

Summary: this project evaluated the effects of a brief manualized mindful eating intervention as a treatment for overeating with individuals with overweight and obesity.

overeating leads to overweight and obesity. effective eating regulation largely depends on an individual's responsiveness to internal cues of physiological hunger and satiety; this phenomenon is known as interoceptive awareness and has been shown to be lower in individuals with overweight or obesity. mindfulness training may improve interoceptive awareness and thus may facilitate more effective regulation of eating through increased sensitivity to cues of hunger and fullness. mindful eating programs have been shown to increase interoceptive awareness of hunger and satiety cues and decrease weight in individuals with obesity. although these programs are effective, they involve lengthy group sessions, require extensively trained staff, and are not widely available outside of clinical research. thus, the reach and impact of these programs are limited. the present study developed and tested a brief mindful eating intervention inspired by kristeller \& wolever's (2010) mindfulness-based eating awareness training program to increase interoceptive awareness in individuals with overweight and obesity as a means to increase mindful and intuitive eating, reduce overeating and facilitate weight loss. the program consisted of 9 weekly 10-15 minute sessions structured around one simple evidence-based mindful eating exercise, and was delivered to adult (ages 18-67) employees from a canadian university.

Eligibility criteria:
inclusion criteria: * bmi of 25 to 45 kg/m2 (overweight/obese) * willingness to commit to program and complete various assessment measures exclusion criteria: * having been pregnant in the past six months or planning on becoming pregnant in the next year * undergoing treatment for cancer * using medications that affect body weight or appetite * being diagnosed with bulimia nervosa, binge-eating disorder, major depressive disorder, or another severe psychiatric disease (including dementia)

Keywords: mindful eating overweight obesity intuitive eating overeating self-compassion
efficacy of l-prf against deproteinized bovine mineralized bone (dbbm)

Conditions: Patients with Posterior Maxillary Atrophy and Need for Sinus Lift Surgery to Allow Implant Placement

Summary: objective: the main objective of this study is to evaluate whether the use of l-prf combined with deproteinized bovine mineralized bone (dbbm; biooss, geistlich pharma®) reduces healing time, through histomorphometric analysis using bone biopsies after maxillary sinus elevation versus the use of deproteinized bovine mineralized bone (dbbm) alone. materials and methods: 24 patients with posterior maxillary atrophy (residual bone height \<5mm without need for vertical regeneration) and need for sinus lift surgery to allow implant placement were treated ,12 dbbm (control group) 12 l-prf block (test group). at 4 months after sinus lift, a biopsy was taken and implants were placed with submerged healing. after 6 months, the second surgical phase was performed and another biopsy was taken. the bone samples collected were analyzed histologically and histomorphometrically. patients received prosthetic restorations after 9 months and were followed up at 12 months. volumetric changes were analyzed at 4 and 12 months.

the study was a double-blind randomized controlled clinical trial (rct), with a parallel design. patients requiring an open sinus lift procedure before implant placement. for the procedure it was use two types of filler, l-prf block (test group) and dbbm alone (control group). all patients were randomized and assigned to each of the study groups through a computer-generated randomization. the primary outcome was percentage of new bone formed after treatment by histological and histomorphometric measurement of biopsies (%neoformedbone=(regenerated bone/total area)x100) at 4 and 6 months.

Eligibility criteria:
inclusion criteria: * patients \>18 years * presence of oral health (periodontally healthy or periodontitis treated), with a bop \<20% and pi \<20%. * systemically healthy, with no disease that might contraindicate oral surgery. * non-smokers or smokers of \<10 cig/day. * need to place implants in postero-superior sector with a residual bone height of \< 5mm (no need for vertical regeneration). * more than 3 months since tooth extraction in the treatment area. * absence of sinus pathology. exclusion criteria: * patients who, due to systemic conditions, blood extraction is not possible. * medication that may interfere with bone metabolism (e.g. corticosteroids, bisphosphonates). * history of radiotherapy. * pregnant and/or breastfeeding women.

Keywords: posterior maxillary atrophy; dental implants; sinus lift; bone grafting; platelet-rich fibrin; alveolar ridge augmentation; bone regeneration; bone substitutes