Kornimate/medical-research-clean huggingface dataset:
microbiology of cerebral abscesses

Conditions: Brain Abscess

Summary: establish the repertoire of bacteria and archaea responsible for brain abscesses. correlate the microbial repertoire to epidemiological, clinical and radiological data; to define the different nosological entities falling within the framework of cerebral abscesses.

brain abscess is a fatal infectious pathology of the central nervous system for which our chu provides a referent function and supports patients suspected and diagnosed with a cerebral abscess in the area of the regional hospital group (ght). through the routine activity of the microbiology laboratory of the ihu méditerranée infection, more than 180 diagnosed patients have been investigated in 9 years, an average of 20 patients per year. the mortality of brain abscesses is currently measured at 15% despite well-established diagnostic and therapeutic protocols in the literature, associating surgical drainage of abscess and administration of probabilistic antibiotics. our hypothesis is that established protocols take into account incomplete microbiological documentation of cerebral abscesses and therefore anti-infectious therapy that may not be strictly adapted to the causative microorganisms. our hypothesis is based on our own work as well as the literature data, showing that current approaches only target bacteria but that these approaches leave aside other living worlds such as archaea. indeed, investigators have recently shown for the first time that methanogens, which are archaea microorganisms, constitute part of the flora responsible for certain cerebral abscesses and that they have a direct pathogenic role in cerebral abscesses. more specifically, the diagnosis of cerebral abscess includes several clinical and microbiological situations that are not all of the same therapeutic. investigator propose to collect 20 abscesses. a collection of abscesses is performed systematically during the diagnosis for bacteriological analysis. there will be no further examination. the main objective of this clinical research project is to establish the repertoire of microorganisms responsible for brain abscesses; and as a secondary objective to define the different clinical entities forming the cerebral abscesses.

Eligibility criteria:
inclusion criteria: * patient diagnosed with a cerebral abscess at admission; and to benefit from an abscess puncture as part of routine care. * affiliate or beneficiary of a social security scheme. exclusion criteria: * pregnant or nursing woman. * major patient under tutorship or curatorship. * patient deprived of liberty or under a court order * patient refusing to participate in the study
investigating the mechanisms of mindfulness-based cognitive therapy (mbct)

Conditions: Major Depression (in Remission)

Summary: this research will investigate the neuropsychological mechanisms underlying the eight-week mindfulness-based cognitive therapy (mbct) programme. participants in remission from depression will be seen pre- and post-mbct to assess the underlying neuropsychological mechanisms. all will be followed-up over 12 months to assess the relationship of these neuropsychological changes with relapse risk. the research will focus primarily on changes in self-compassion, rumination, attention and structural brain changes, with secondary focus on other mechanisms of emotional processing and memory.

there will be three groups in total. * the first group will take 36 participants in remission from major depression (rmdd) through the 8 week mbct program. * a control group of 36 rmdd participants will not receive the intervention. * a group of never depressed healthy control participants will also be recruited. research visits for participants not undergoing mbct will be separated by an 8 week gap. all participants will be seen before and after the 8 weeks for completion of neuropsychological assessments and questionnaires. rmdd participants will be followed up over the following 12 months to identify any predictors of relapse.

Eligibility criteria:
inclusion criteria: participants with remitted depression (rmdd): * at least two previous episodes of dsm-iv major depression in adulthood, diagnosed using the mini international neuropsychiatric interview (m.i.n.i). * full or partial remission for at least three months with two depressive episodes within the last five years. * a score of less than or equal to 12 on the montgomery asberg depression rating scale (madrs) mood assessment. * if on medication, no recent or planned major changes healthy volunteers: * in good psychological health screened with the m.i.n.i all participants: * in good physical health (to reduce risk of confounding physical health problems). * sufficiently fluent in english to ensure valid understanding and completion of the tasks. * minimum i.q level of 80 to ensure sufficient understanding of the neurocognitive tasks administered. * colour vision and acuity within normal/corrected to normal limits. exclusion criteria: * any current mental health diagnosis (dsm-iv diagnosis including current major depression, bipolar disorder, psychosis, obsessive compulsive disorder (ocd), substance abuse or dependence, eating disorders) * physical health or neurological disorders that might interfere with the interpretation of the tasks, including a history of significant head injury. * in addition healthy volunteers will be without a history mental health disorders (dsm-iv) * current or previous experience of mindfulness-based treatments or extensive cognitive behavioural treatment, or planned participation in psychological treatments during the key time for the study (between pre and post visits). * planned major alteration in drug treatment for depression between pre and post visits.
loop diuretic therapy in acutely decompensated heart failure

Conditions: Acute Heart Failure

Summary: diurhf is a prospective, multicenter, observational, study that compares continuous with intermittent infusion of furosemide in patients admitted with a diagnosis of adhf. previous pilot study design was planned to anticipate a larger multicenter trial able to definitively evaluate the optimal loop diuretic use strategy in patients with adhf.

the use of intravenous loop diuretics is a cornerstone of therapy for acutely decompensated heart failure (adhf); significant concerns have been raised regarding risks and benefits of loop diuretics, particularly about dosage and administration regimen. recent guidelines recommend the use of these drugs to reduce left ventricular filling pressure, avoid pulmonary edema, and alleviate peripheral fluid retention. some studies have provided guidelines for the administration of these drugs in clinical practice, but data interpretation remains challenging due to the frequent exclusion of patients with kidney disease from major adhf clinical trials. therefore, it is not clear if continuous infusion is better than intermittent boluses in terms of decongestion, maintenance of renal filtration function and prognosis. on the other hand, continuous administration should provide a more constant delivery of the drug into the tubule, potentially reducing these phenomena. the aim of the study is to evaluate the better loop diuretic intravenous administration in terms of renal function, congestion signs, bnp and outcome.

Eligibility criteria:
inclusion criteria: * patients over 18 years; * patients with diagnosis of adhf(dyspnea, orthopnea, peripheral edema or major fatigue and at least two clinical signs including rales, hepatomegaly, pulmonary congestion on chest radiography, jugular vein dilatation, or a third heart sound); * blood bnp \> 100 pg/ml; adhf: acute decompensated heart failure; bnp: b-type natriuretic peptide; iv: intravenous; lvef: left ventricular ejection fraction. exclusion criteria: * patients who receive more than 40 mg of iv furosemide; * end-stage renal disease or renal replacement therapy; * recent myocardial infarction (within thirty days of screening); * systolic blood pressure \< 80 mmhg; * creatinine levels \> 4 mg/dl; * patients affected by sepsis, liver diseases, inflammatory diseases or neoplastic diseases.

Keywords: loop diuretic heart failure renal dysfunction congestion signs bnp
clinical efficacy of early administration of convalescent plasma among covid-19 cases in egypt

Conditions: Convalescent Plasma; Covid19; Immunoglobulins; Plasma; Egypt

Summary: one investigational treatment being explored for covid-19 is the use of convalescent plasma collected from individuals who have recovered from covid-19 (refs. 1-4). convalescent plasma that contains antibodies to severe acute respiratory syndrome coronavirus 2 or sarscov-2 (the virus that causes covid-19) is being studied for administration to patients with covid-19. use of convalescent plasma has been studied in outbreaks of other respiratory infections, including the 2003 sars-cov-1 epidemic, the 2009-2010 h1n1 influenza virus pandemic, and the 2012 mers-cov epidemic (refs. 5-7). although promising, convalescent plasma has not yet been shown to be safe and effective as a treatment for covid-19. therefore, it is important to study the safety and efficacy of covid19 convalescent plasma in clinical trials. this guidance provides recommendations to health care providers and investigators on the administration and study of investigational convalescent plasma collected from individuals who have recovered from covid-19 (covid-19 convalescent plasma) during the public health emergency. this guidance also provides recommendations to blood establishments on the collection of covid-19 convalescent plasma..

laboratory-confirmed patients using qrt-pcr will be enrolled in the study. eligibility criteria for recipients are ; laboratory-confirmed sars-cov-2, severe or immediately life-threatening. severe disease defined as one or more of the following; shortness of breath( dyspnoea), respiratory frequency≥ 30/min, blood oxygen saturation ≤93%, a partial pressure of arterial oxygen to fraction of inspired oxygen ratio \ 50% within 24-48 hours. while a life-threatening disease is defined as one or more of the following; respiratory failure, need for mechanical ventilation, septic shock and multiple organ dysfunction or failure. intervention: all patients included in the study provided will be administered with two plasma units (each unit is 200cc). primary measure is the degree of clinical improvement among the covid-19 patients who receive cpt within seven days as compared with the patients who receive after seven days. case fatality will be assessed among the enrolled cases

Eligibility criteria:
inclusion criteria: laboratory confirmed covid-19. severe or immediately life-threatening covid-19, exclusion criteria not fitting inclusion criteria
social media use of psoriasis vulgaris patients: multicenter, survey work

Conditions: Psoriasis Vulgaris

Summary: psoriasis vulgaris is a chronic, recurrent, inflammatory and hyperproliferative skin disease. joint involvement is common along with skin involvement. however, metabolic diseases, such as cardiovascular diseases can be accompanied by many systemic diseases, chronic and repetitive due to the quality of life and psychological status of patients can affect. for this reason, patients carry out various research on their diseases on social media and follow programs on these issues in other media such as television and radio. however, there is no study on how much patients are interested in these publications, how much they trust them, and how they reach and organize information via social media. the aim of the study will be to clarify how and how patients with psoriasis vulgaris use social media to obtain information about the diagnosis and treatment of their disease, the interaction of patient groups with each other, and how often social media is used, especially in which group of patients.


Eligibility criteria:
inclusion criteria: * psoriasis vulgaris patients exclusion criteria: * patients that don't want to answer questions
screening and prospective cohort study of risk factors for enhanced recovery after spinal fusion surgery in advanced age patient

Conditions: Lumbar Disk Herniation; Lumbar Spinal Stenosis; Lumbar Spondylolisthesis; Cervical Spondylotic Myelopathy; Cervical Radiculopathy

Summary: to determine the high risk factors affecting accelerated recovery after spinal fusion surgery in advanced age patient.

to determine the high risk factors affecting accelerated recovery after spinal fusion surgery in elderly patients: a prospective cohort study

Eligibility criteria:
inclusion criteria: 1. informed consent signed and dated by subject or guardian 2. commit to follow the research procedures and cooperate with the whole process of the study 3. the subjects are 60 years old or older, regardless of gender 4. patients with degenerative spinal diseases requiring spinal fusion surgery 5. generally in good physical condition 6. able to adhere to and cooperate with research interventions, such as oral medication 7. in fertile women, contraception should be used for at least one month prior to screening, and they should commit to use contraception throughout the study period and continue until the specified time after the study exclusion criteria: 1. acute infection 2. congenital malformation 3. abnormal anatomy or skeletal variation 4. malignant tumor 5. the surgical area was locally infected with symptoms of local inflammation 6. fever or leukocytosis 7. morbid obesity 8. pregnant and nursing women 9. mental illness 10. acute joint disease, bone resorption, osteopenia and/or osteoporosis. osteoporosis is a relative contraindication, as this condition may limit the degree of correction that can be produced, the amount of mechanical fixation, and/or the quality of the bone graft 11. patients who are unwilling to cooperate with post-operative treatment 12. any time an implant is performed it interferes with the anatomy or intended physiological function of the patient

Keywords: enhanced recovery after surgery (eras) spinal fusion surgery advanced age patient high risk factors
the effect on function of increasing activity for nursing home residents

Conditions: Frailty; Nursing Home Residents

Summary: as designs of existing outcome studies are disparate and do not always relate well to a swedish context, the need for further studies is obvious. also, an empirical theory drawn from the best practice supporting autonomy and wellbeing for clients in a nursing home setting has not yet been fully depicted. the study described below intends to fill a gap in knowledge related to the effect of enhanced activities of daily living (adl)-training, physical, and daily activities and staff education in a nursing home setting, based on a theory- and evidence-based intervention programme in a swedish as well as a nordic health care context. the aims of the study are to describe the impact of an individually tailored intervention program, in a nursing home setting, on: * physical capacity * degree of dependence in adl * long-term participation in physical and/or daily activities * self-rated wellbeing

the trondheim study has additional aims to assess the impact of intervention on: * urinary incontinence * falls

Eligibility criteria:
inclusion criteria: * \> 65 years of age * expected stay in the nursing home \> 3 months * able to take instruction exclusion criteria: * persons in a terminal phase

Keywords: exercise functioning frail elderly
randomized controlled trial of laparoscopic gastric bypass plus omentectomy versus laparoscopic gastric bypass alone in improving diabetic indices

Conditions: Diabetes; Interleukins; Cytokines

Summary: to see if removing the omentum in addition to a gastric bypass improves diabetes is better than just a gastric bypass.


Eligibility criteria:
inclusion criteria: * undergoing laparoscopic gastric bypass, \>18 yo, understands english exclusion criteria: * previous lower pelvic surgery, self-pay patients, previous weight loss surgery,

Keywords: obesity diabetes cytokines
acute lymphoblastic leukemia treatment protocol moscow-berlin 2019 pilot

Conditions: Childhood Acute Lymphoblastic Leukemia

Summary: the purpose of the study is to optimize the therapy of patients with primary b-cell precursor acute lymphoblastic leukemia (bcp-all) by including monoclonal bispecific antibodies in post-induction treatment with simultaneous reduction of chemotherapy. questions and objectives of the study: * to determine the efficacy and feasibility of chemotherapy and immunotherapy combination in comparison with standard pct in children and adolescents with newly diagnosed bcp-all; * to determine the safety and toxicity of chemotherapy and immunotherapy combination in comparison with standard pct in children and adolescents with newly diagnosed bcp-all; * to determine the possibility of chemotherapy reducing when immunotherapy is included in the treatment regimen without loss of effectiveness; * to determine the possibility of reducing the maintenance therapy duration to 1 year when immunotherapy is included in the treatment regimen without loss of effectiveness.


Eligibility criteria:
inclusion criteria: this study included patients with b-cell precursor all (bcp-all) diagnosed or confirmed in one of the clinics participating in the study. also following criteria should be considered at the diagnosis for each case: 1. age at diagnosis at 1 to 18 years. 2. the start of induction therapy within a time interval of study recruitment phase. 3. the diagnosis of bcp-all is to be proved by the morphological, cytochemical, and immunological analysis of tumor cells in bone marrow in the reference laboratories of dmitry rogachev national medical research center of pediatric hematology, oncology and immunology (d. rogachev nmrcphoi). 4. cd19 expression on tumor cells. 5. informed consent of the patient parents (guardians) exclusion criteria: 1. any non-compliance with the inclusion criteria. 2. all is a second malignancy. 3. there is severe concomitant disease, which significantly impedes chemotherapy protocol (such as multiple malformations, heart diseases, metabolic disorders, etc.); 4. the patient was treated before for a long time with cytotoxic drugs. 5. initial cns (central nervous system) involvement (status cnsii or cnsiii). 6. initial leukocyte count ≥100×109/l (except for patients with significant translocations). 7. patients not achieved cytological remission after induction

Keywords: acute lymphoblastic leukemia children chemotherapy immunotherapy blinatumomab
transcutaneous electrical acupoint stimulation(teas) for postoperative nausea and vomiting in laparoscopic operation

Conditions: Postoperative Nausea and Vomiting

Summary: this is a single center, randomized, double-blinded, controlled clinical trial.the purpose of this study is to compare the effect of teas pretreatment with single acupoint or two acupoints for postoperative nausea and vomiting in patients undergoing laparoscopic operation.

patients were randomly assigned to four groups, receiving teas 30 minutes before induction.the stimulation was applied until the end of the operation. postoperative nausea and vomiting was recorded 30 minute, 2 hour, 6 hour and 24 hour after the operation. the adverse events were recorded as well.

Eligibility criteria:
inclusion criteria: 1. asa i-iii 2. aged 18 to 65 years old 3. scheduled for general anesthesia 4. bmi index is between 18 to 30 5. informed consented exclusion criteria: 1. asa iv 2. hypertension that is not controlled 3. severe hepatic or renal dysfunction 4. ever had received electrical stimulation treatment 5. severe systemic infection 6. with contraindications to the use of teas, such as skin damage or infection at the acupoints 7. for any reason one can not cope with the studies, such as the following: language comprehension, mental illness 8. participate in the other clinical trial 3 month before the enrollment

Keywords: postoperative nausea and vomiting teas
plado for conservative management of ckd

Conditions: Chronic Kidney Disease(CKD); Metabolic Acidosis

Summary: the goal of this clinical trial is to learn if a plant-dominant low protein diet, referred to as plado diet, works to decrease metabolic acidosis, a major risk factor for chronic kidney disease (ckd) progression, in adults with ckd. it will also learn about the safety, viability, and economic attractiveness of this diet. the main questions it aims to answer are: * is the plado diet more effective in managing metabolic acidosis in comparison with the standard-of-care ckd diet in adults with ckd? * is the plado diet safe, viable, and economically attractive adults with ckd? researchers will compare the plado diet to the standard-of-care ckd diet to see if the plado diet works better to decrease metabolic acidosis. participants will: * receive nutrition education of the plado diet or the standard-of-care ckd diet via monthly sessions for 6 months. * visit the clinic monthly for 6 months, then after 3 months for checkups and tests.


Eligibility criteria:
inclusion criteria: * patients aged 18 years and above, having controlled glycemic and blood pressure parameters on treatment, with an established diagnosis of stages 3-5 ckd and an estimated gfr ≤59 ml/min/1.73 m2 stable for at least three months, and with a normal nutritional status as defined by the glim criteria, attending the ckd outpatient clinics at laumc-rh, willing to undergo the baseline screening and attend the monthly face-to-face visits at the outpatient department at laumc-rh. exclusion criteria: * patients with overt infection, persistent anorexia, vomiting, or diarrhea within the last month, presence of wasting diseases such as cancer, tuberculosis, liver failure, heart failure, and those with serum potassium \>5.5 meq/l during the past 6 months.

Keywords: chronic kidney disease metabolic acidosis plado plant-dominant low protein diet nutrition education
assessment of shoulder rehabilitation practices and documentation protocols at riphah rehabilitation center

Conditions: Shoulder Pain; Shoulder Impingement; Rotator Cuff Injury

Summary: this study aims to evaluate riphah rehabilitation center's shoulder rehabilitation procedures and documentation guidelines. the study will specifically assess the efficacy of shoulder rehabilitation procedures, their methodology, and the techniques employed to record patient improvement. in order to make sure the centre adheres to best practices, improves patient care, and keeps accurate records for better treatment outcomes, the study intends to identify areas of strength and potential improvements in both the rehabilitation techniques and documentation processes. the evaluation's findings will improve the center's operational effectiveness and clinical practices. target audience:healthcare professionals (such as physicians, physiotherapists, and rehabilitation therapists): this study will assist guide evidence-based strategies for managing shoulder injuries and offer insights into contemporary rehabilitation procedures. centre administration: for better patient care, resource management, and operational efficiency, the results will point out areas where documentation and treatment protocols should be strengthened. patients and families: in the end, the study will improve rehabilitation results, increasing the likelihood that patients will heal from shoulder injuries more quickly and completely.


Eligibility criteria:
inclusion criteria: * patients undergoing shoulder rehabilitation at rphah rehabilitation center. * rehabilitation protocols implemented within the center. * documented cases with sufficient information for analysis. * both acute and chronic shoulder conditions exclusion criteria: * patients with shoulder conditions not requiring rehabilitation. * cases lacking adequate documentation. * rehabilitation protocols not specific to shoulder conditions. * patients with comorbidities significantly affecting rehabilitation outcomes.

Keywords: shoulder pains shoulder impingement ,shoulder documentation