Kornimate/medical-research-clean huggingface dataset:
exercise intervention metabolic syndrome prostate cancer black men

Conditions: Physical Activity; Metabolic Syndrome; Prostate Cancer

Summary: the main purpose of this study is to examine the feasibility of an exercise intervention on metabolic syndrome (mets) components and biomarkers related to prostate cancer in black men with mets who are at increased risk of prostate cancer.

the specific aim for the proposed study is to examine the feasibility and impact of a 6-month two-arm randomized controlled trial (rct) on mets components and biomarkers related to prostate cancer in black men with mets. due to the striking racial disparities of prostate cancer, this proposal will focus on the impact of an aerobic and resistance exercise intervention on mets and biomarkers related to prostate cancer in black men. specifically, our proposed clinical trial compares an aerobic and resistance exercise intervention to an attention control group among black men.

Eligibility criteria:
inclusion criteria: 1. african-american and/or black men; 2. between the ages of 40-70 years; 3. waist circumference \>40 inches (102 cm); 4. with at least two of the following: elevated bp (≥ 130/85 mmhg); 5. elevated fasting glucose (≥ 100 mg/dl), reduced hdl cholesterol (\<50 mg/dl), or elevated triglycerides (≥ 150 mg/dl); 6. sedentary defined as \<60 minutes of recreation or work requiring modest pa/week; 7. be able to speak and read english; 8. able to provide meaningful consent (i.e., men with severe cognitive impairment will be excluded); 9. have no physical limitations that prevent from exercising; 10. and have access to a television and dvd player. exclusion criteria: 1. history of cancer except nonmelanoma skin cancer; 2. current enrollment in another clinical trial or weight loss program; 3. inability to commit to the intervention schedule. prior to randomization, participants will be required to have a signed authorization and medical clearance from their personal physician or our nurse practitioner.

Keywords: prostate cancer african-american metabolic syndrome exercise men's health
implementation and effectiveness of mindfulness oriented recovery enhancement as an adjunct to methadone treatment

Conditions: Opioid Use; Pain

Summary: this hybrid implementation-effectiveness trial will evaluate mindfulness-oriented recovery enhancement (more) for patients with opioid use disorder receiving methadone treatment (mt). the investigators will also assess barriers and facilitators to integrating more into methadone treatment, and evaluate the impact of a sustainable train-the-trainer model on provider burden, intervention fidelity, intervention engagement, and outcomes. participants will be assigned to a higher intensity more implementation strategy, a minimal intensity implementation strategy consisting of a simple, scripted mindfulness practice (smp) extracted from the more treatment manual with minimal training and feedback and no supervision, or methadone treatment as usual (tau). we aim to: * examine barriers and facilitators to the implementation of more and smp in mt and evaluate strategies for optimizing training, fidelity, and engagement. * evaluate the effectiveness and treatment fidelity of a higher intensity more implementation strategy versus a lower intensity, scripted mindfulness practice (smp) implementation strategy as an adjunct to methadone tau or methadone tau, only. outcomes include opioid and other drug use, craving, mt discontinuation, depression, anxiety, and physical pain (secondary outcomes) than patients randomized to tau.


Eligibility criteria:
inclusion criteria: * english-speaking * age ≥18 * currently on methadone * persistent or recurring pain that has lasted for a duration of 3 months of longer. exclusion criteria: * severe cognitive impairment (score \>23 on mini mental status exam) or psychosis (positive scid psychotic screen) * suicidal risk (score ≥7 on suicidal behaviors questionnaire) * inability to attend or fully participate in intervention sessions or assessments * previous formal mindfulness training (e.g., mbsr, mbrp) or more (from the r21 or r33 studies).
hrct in prediction of tumor invasion in ggo lung adenocarcinoma (ectop-1008)

Conditions: Adenocarcinoma of Lung

Summary: this study is one of eastern cooperative thoracic oncology projects (ectop-1008). it aims to evaluate the correlation between radiological diagnosis based on hrct and pathological invasiveness.investigators observe the radiological features and the correlation with the postoperative pathological findings.

preoperative evaluation of pathologic tumor invasion of ground glass opacity (ggo) featured lung adenocarcinoma is important for selection of appropriate surgical extent. whether thoracic high-resolution computed tomography (hrct) scan could precisely predict pathologic tumor invasion remains unknown. patients with peripheral ggo nodules (ggns) would be enrolled, and hrct with target scan would be performed preoperatively. pathologic tumor invasion (invasive adenocarcinoma \[iad\] versus adenocarcinoma in situ \[ais\]/minimally invasive adenocarcinoma \[mia\]) would be evaluated according to radiologic parameters of hrct before surgery. primary endpoint of this trial is the diagnostic sensitivity of pathologic tumor invasion evaluated by hrct. secondary endpoint is the diagnostic value of radiologic parameters of hrct for pathologic tumor invasion of ggo featured lung adenocarcinoma.

Eligibility criteria:
inclusion criteria: (1) ggns on hrct scan; (2) clinical stage ia; (3) simultaneously no more than three nodules; (5) age ranging from 15 to 85 years. exclusion criteria: (1) pathologically confirmed non-adenocarcinoma; (2) patients who did not receive surgery.
clinical and pharmacokinetic trial of intra-abdominal irinotecan

Conditions: Adenocarcinoma; Gastric Cancer

Summary: this is a research study for patients that have an advanced cancer that is confined mostly to the abdominal cavity and have failed treatment with conventional therapy, or for which no standard treatment exists. the purpose of this study is to determine the dose of a chemotherapy drug (called irinotecan) that can be administered safely into the abdominal cavity. we also wish to identify the side effects of irinotecan when it is administered directly into the abdomen. in this study, we will also determine the levels of irinotecan in the blood and in the abdominal cavity. irinotecan is a chemotherapy drug that can decrease the size of several different tumors. it is approved by the fda for the treatment of colon cancer. it appears that some other chemotherapy drugs are more effective and may have less side effects when they are administered directly into the abdomen.


Eligibility criteria:
inclusion criteria: * histologically confirmed recurrent, metastatic, or residual cancer with disease confined mostly to the peritoneal cavity. patients with asymptomatic extra-peritoneal disease are eligible. * measurable or evaluable disease. patients with malignant ascites or carcinomatosis only (documented by cytology or during surgery) are eligible. patients with ovarian cancer and disease manifested only by an elevated ca-125 are also eligible. * adequate hepatic, renal, and bone marrow functions: bilirubin less than or equal to 2.0 mg/dl; creatinine less than or equal to 2.0 mg/dl, alkaline phosphatase less than or equal to 3 x upper limit of normal (uln), ast or alt less than or equal to 3 x uln; agc greater than or equal to 1500, platelets greater than or equal to 100,000. * swog performance status 0-2 * fully recovered from acute toxicities from prior surgery, chemotherapy, or radiation therapy. * patients must use an approved method of birth control. exclusion criteria: * medical, social, or psychological factors which could prevent patient from receiving treatment. * prior therapy with intra-peritoneal irinotecan * significant intra-peritoneal adhesions detected clinically or by prior surgical exploration

Keywords: solid tumor phase i phase one
dimethyl fumarate treatment for intracranial unruptured aneurysms.

Conditions: Intracranial Aneurysm; Aneurysm, Brain; Inflammation Vascular

Summary: this study was designed to identify whether there is a measurable reduction in inflammation in walls of intracranial aneurysms with oral dimethyl fumarate.

intracranial aneurysm (ia) is a common cerebrovascular disease and the main cause of nontraumatic subarachnoid hemorrhage. once ruptured, it will cause a high mortality rate, and nearly half of the survivors will also have disabilities. after comparing surgical risk and rupture risk, a significant proportion of patients with intracranial aneurysms choose conservative observation. previous studies suggest that inflammation of aneurysmal wall is a high-risk factor of rupture. dimethyl fumarate (dmf) acts as an anti-inflammatory agent by activating nuclear factor erythroid 2-related factor 2(nrf2) and other pathways. animal experiments found dimethyl fumarate reduces the formation and rupture of intracranial aneurysms. mri high-resolution vessel wall imaging (hr-vwi) has become a valuable method to assess the wall of unruptured intracranial aneurysms. using hr-vwi, it may be possible to detect smaller or more subtle areas of signal enhancement and change, which may give a more precise understanding of the pathology. in this study, dmf was evaluated for its ability to reduce inflammation of the aneurysm wall measured with high-resolution vessel wall imaging (hr-vwi).

Eligibility criteria:
inclusion criteria: 1. male or female aged ≥18 years. 2. unruptured ia of ≥3mm identified on imaging (ct, mri or digital subtraction angiography). 3. aneurysm wall enhancement identified by hr-vwi before treatment. 4. ability to understand the objective of the trial with provision of written informed consent. exclusion criteria: 1. mri contraindications (metallic implant, contrast allergy, claustrophobia, etc). 2. planned treatment of the aneurysm within 12 months. 3. current treatment with drugs that might have an anti-inflammatory effect (aspirin, statins, immunosuppressive drugs, etc.). 4. severely impaired liver or renal function. 5. retreatment of recurrent aneurysm. 6. pregnant or lactating women. 7. malignant diseases (liver disease, kidney disease, congestive heart failure, malignant tumours, etc.). 8. poor compliance.

Keywords: dimethyl fumarate high resolution magnetic resonance
the use of nursing-students-led bcbtmi

Conditions: Internet Addiction

Summary: the use of the internet is very popular in adolescence. notwithstanding the benefits from the internet, many users are addicted to the internet and develop problematic behaviours which are regarded as "internet addiction" (ia). trained nursing students, who are the future nurses and well-equipped with basic health knowledge, as the interventionists to deliver a bcbtmi intervention to the eligible subjects. the result of this study is expected to provide evidence of the feasibility and effectiveness of training nursing students to conduct bcbtmi in hong kong chinese adolescents with ia for a definitive rct.

a two-arm, parallel-group, feasibility cluster randomized controlled trial will be conducted. 60 adolescents with ia will be recruited from secondary schools in hong kong. participants in the intervention group will receive 4 weekly 30-45 minute sessions using the brief cbt and the brief mi models by nursing students. control group participants will receive routine care for ia.

Eligibility criteria:
inclusion criteria: * aged 13 to 17 * studying forms 2 to 4 * classified as ia by the chinese version of young's 10-item internet addiction test (iat) * can communicate in cantonese and read chinese. exclusion criteria: * with physical or cognitive impairment and learning problems as identified from the medical records

Keywords: adolescents nursing-students-led cognitive behavioural therapy motivational interviewing
performance evaluation of malaria plus rapid diagnostic tests (rdts) for the detection of plasmodium infections in patients with symptoms suggestive of malaria

Conditions: Malaria

Summary: this trial is part of a portfolio of studies designed to assess the clinical and operational performance of abbott's nxtektm malaria pf plus and nxtektm malaria pf/pv plus rapid test devices.

a prospective cross-sectional multi-center diagnostic accuracy trial in intended-use settings of the: 1. nxtektm malaria pf/pv plus rapid test device for the qualitative detection histidine-rich protein ii (hrp-ii antigens) and pldh of plasmodium falciparum (p.f) and plasmodium vivax (p.v) malaria in human whole blood. 2. nxtektm malaria pf plusrapid test device for the qualitative detection of histidine-rich protein ii (hrp-ii antigens) and pldh of plasmodium falciparum (p.f) malaria in human whole blood.

Eligibility criteria:
inclusion criteria: * aged 5years old or older * presenting at the trial site with fever or a history of fever (axillary temp ≥ 37.5c) during the preceding 48hours * freely agreeing to participate by providing informed consent (and assent, if applicable) exclusion criteria: * presence of symptoms and signs of severe illness and/or central nervous system infections as defined by who guidelines.

Keywords: plasmodium infection plasmodium falciparum plasmodium vivax
examining the effect of the nicotine patch in male and female smokers - 3

Conditions: Drug Addiction; Smoking Cessation

Summary: treatment studies have demonstrated that current smoking cessation techniques are less effective for women. the purpose of this study is to determine the role that gender plays in the effectiveness of nicotine replacement therapy. in addition, the purpose of this study is to determine whether men and women differ in their response to smoking-related stimuli (e.g., taste or smell of a lit cigarette). conclusions drawn from this study may help to improve cessation interventions for all smokers, particularly women.

currently,about 70 percent of smokers who try to quit by using smoking cessation treatments are unsuccessful. treatment studies have demonstrated that current smoking cessation techniques are less effective for women. there is no clear explanation for this difference, but it may involve a differential response to nicotine replacement treatments (nrts) and/or smoking-related stimuli. for women, nrt may be less effective at suppressing withdrawal or blunting the effects of smoking during a quit attempt. women may also be more sensitive to smoking-related stimuli, suc has the taste, sight, or smell of cigarette smoke. tailoring treatments to the separate needs of smoker subgroups , such as men and women, my produce better cessation outcomes. the purpose of this study is to assess whether men and women differ in the their response to nrt (i.e., transdermal nicotine) and smoking-related stimuli. participants in this double-blind, dose-comparison study will complete separate sessions in random order. each session will last approximately 6.5 hours and will correspond to a transdermal patch dose (0 or 21mg) and cigarette type (denicotinized and nicotinized). objectively verified cigarette abstinence will be required before each session. sessions will occur at least 48 hours apart to avoid carryover. at the beginning of each session a patch will be placed on the participant's back and at 4, 5, and 6 hours after patch application the participant will smoke a cigarette (all identifying marking on the cigarette will be covered for blinding purposes). physiological, subjective, cognitive, and smoking behavior outcomes will be collected during study visits.

Eligibility criteria:
inclusion criteria include, but are not limited to: 18-50 years of age smokes 15 cigarettes/day for at least 2 years healthy (as determined by a brief study physical with medical doctor) displays understanding of cognitive tasks. exclusion criteria include, but are not limited to: history of chronic health problems or psychiatric conditions history of cardiovascular disease, low or high blood pressure, seizures, head injuries requiring hospital care, peptic ulcer, or diabetes pregnancy (tested by urinalysis) scores greater than 17 on the beck depression inventory lack of a high school degree or ged

Keywords: nicotine replacement therapy tobacco smoking smoking stimuli gender
changes in circulating sclerostin levels during acute postsurgical hypoparathyroidism

Conditions: Hypoparathyroidism Postprocedural

Summary: to investigate changes in sclerostin levels following acute post-thyroidectomy hypoparathyroidism

female patients with thyroid disorders, referred to the department of head and neck surgery, at metaxa anti-cancer hospital of piraeus, for total thyroidectomy. based on the development of biochemical hypocalcemia (cca \< 8.4 mg/dl), subjects were divided into 2 groups: group a: without postsurgical hypoparathyroidism that served as controls and group b: subjects, with acute postsurgical hypoparathyroidism. blood collections were performed in the morning after an overnight fast, in at least 3 different time points; preoperatively, 1st postoperative day and 7th postoperative day for the detrmination of sclerostin levels

Eligibility criteria:
inclusion criteria: * indication for total thyroidectomy exclusion criteria: * parathyroid disorders, chronic kidney disease (egfr\ 1 month) or current corticosteroid use

Keywords: sclerostin hypoparathyroidism
pca patients managed with adt to examine the effect of nutritional guidance and aerobic/resistance fitness training

Conditions: Cancer of the Prostate

Summary: the purpose of this observational study is to examine the level of activity in the prostate cancer population treated with androgen deprivation therapy (adt).

the aim of the current observational study will be to examine the level of activity in the prostate cancer population treated with adt therapy; specifically, the impact of physical activity levels along with nutritional guidance through physician support. the application of an innovative technology to motivate patients will also be examined through the provision of an accelerometer/pedometer (nike+ fuelband). the physical activity will be monitored by a nike+ fuelband or tracked on an activity log.this study will assess the clinical and patient reported outcomes relevant to the management of their prostate cancer, in conjunction with a program assessing daily physical activities and nutritional guidance on the impact on the patient's quality of life, mobility and weight maintenance.

Eligibility criteria:
inclusion criteria: * male patient aged ≥ 18 years old * able to read and sign an approved informed consent form (icf) * diagnosed with locally advanced or metastatic prostate cancer * patient is treatment naive for adt or has started adt (3 or 4 month depot injection) and has not received more than 1 treatment of 3 or 4 month adt or patient is on intermittent therapy with an adt agent and will be restarting adt (3 or 4 month depot injection) * ecog (eastern cooperative oncology group) score of ≤ 2 * willingness to track weekly physical activities with or without participating in a home based exercise program during the course of this study. the physical activities will be tracked with a weekly activity log or a nike+ fuelband exclusion criteria: * currently participating in a clinical study or observational study * has a survival expectancy of \< 2 years * has any other condition that, in the opinion of the treating physician, may affect the patient's health or outcome of the trial
cardio-respiratory health and indoor pollution

Conditions: Pulmonary Disease; Cardiovascular Disease

Summary: the aim of this study is to assess in the sample of population resident in the khumbu valley (nepal): 1. the respiratory function decline by means of spirometry and the respiratory health by means of questionnaire and six-minute walking distance 2. the presence of markers of early atherosclerosis with ultrasound and to estimate the value of systolic pulmonary pressure in comparison with not exposed subjects. the investigators hypothesize that the chronic exposure to indoor pollution 1. can accelerate the physiological respiratory function decline, usually around 15-20ml/year in healthy subjects 2. induce cardiovascular impairment the population of high altitude villages is a unique sample to study the effect of the only indoor pollution. in fact, the absence of traffic, due to the lack of roads, and the very low level of smoking habits allow to have no other confounding factors 3. to study and analyze how the architectural features of the buildings of the village (distribution of domestic locals, natural or non natural ventilation systems, domestic activities, materials used, etc.) affect the indoor pollution from carbon monoxide, which necessarily is developed indoor during the daily life activities. what the project prospects is to gather information focused on the scale of the building, independently from the typology, to study a model that will help to describe which aspects are most important to what concern the genesis of the pollution of the indoor air.


Eligibility criteria:
inclusion criteria: * residents in the villages of the valley exclusion criteria: * under the age of 14

Keywords: high altitude respiratory function cardiorespiratory health indoor pollution
strategy to avoid excessive oxygen for critically ill trauma patients

Conditions: Critical Illness; Wounds and Injury; Disease Attributes; Pathologic Processes

Summary: the objective is to determine the effectiveness of a multimodal educational intervention to reduce supplemental oxygen use in critically injured patients. investigators will also evaluate the safety and clinical effectiveness of the more targeted use of oxygen therapy.

oxygen therapy has undisputed importance in the care of critically ill patients to prevent secondary complications related to hypoxemia. although routine, the practice of excessive over-oxygenation may be harmful. an expert panel was convened and developed the strong consensus to target normoxemia at an oxygen saturation (spo2) range of 90-96%, an arterial oxygen (pao2) range of 60-100 mmhg (when applicable), and a fraction of inspired oxygen (fio2) of 21% for mechanically ventilated patients or room air for nonmechanically ventilated patients. specific aim: the purpose of this study is to determine the effectiveness of a multimodal educational intervention to reduce supplemental oxygen use in critically injured patients. investigators will also evaluate the safety and clinical effectiveness of the more targeted use of oxygen therapy. hypotheses: clinical efforts to through a multimodal educational intervention will: 1. improve the proportion of time spent within target normoxemia thresholds (oxygen saturation \[spo2\] 90-96% and/or arterial oxygen \[pao2\] 60-100 mmhg \[when applicable\] 2. limit use of excessive supplemental oxygen 3. reduce exposure to hyperoxemia without a substantive increase in hypoxemic episodes or adverse effects

Eligibility criteria:
inclusion criteria: * acutely injured patients who meet the criteria for entry into the state or national trauma registry * admission to surgical/trauma icu within 24 hours of hospital arrival exclusion criteria: * age \<18 years * prisoners * known pregnancy * transferred patients not admitted through the emergency department

Keywords: hypoxia hyperoxia trauma burn critical illness supplemental oxygen oxygenation spo2 pao2 fio2 normoxia hypoxemia normoxemia hyperoxemia