Kornimate/medical-research-clean huggingface dataset:
study of the impact of cd34+ cell dose on absolute lymphocyte count following high-dose therapy and autologous stem cell transplantation for relapsed and refractory diffuse large b-cell lymphoma (dlbcl)

Conditions: Diffuse Large B-cell Lymphoma (DLBCL); Relapsed Diffuse Large B-cell Lymphoma (DLBCL); Refractory Diffuse Large B-cell Lymphoma (DLBCL)

Summary: the purpose of this study is to study the impact of stem cell dose on outcome after autologous transplant.

following enrollment, patients will be cd34+ stem cell mobilized at the discretion of the treating attending physician with the plerixafor for the achievement of \>6 x10\^6 cd34+ cells/kg. the patients that fail to mobilize \>6 x10\^6 cd34+ cells/kg will not be randomized and will subsequently be followed for disease progression and overall survival.. patients with \>6 x10\^6 cd34+ cells/kg cryopreserved on study will be admitted to the hospital for planned asct. patients will be randomly infused with either 3-4 x 10\^6 cd34+ stem cells/kg or 6-8 x10\^6 cd34+ stem cells/kg on d0 per study randomization. the cell dose ranges within the two groups allows variability within aliquots of cells at the time of cryopreservation. patients will receive standard supportive measures (including: growth factor support post-hdt/asct, antimicrobial prophylaxis, red blood cell and platelet transfusion and treatment for neutropenic fever) as per institutional guideline practices.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years old * diagnosed with relapsed or refractory de novo dlbcl or follicular lymphoma transformed to dlbcl to one previous line of anthracycline-containing chemotherapy * kps ≥ 70 * complete or partial response by iwg working group or icml criteria to maximum of one salvage line of chemotherapy without pre-hdt/asct salvage radiotherapy. * eligible for high-dose therapy and autologous stem-cell rescue * serum creatinine ≤ 1.5 mg/dl, or if creatinine \>1.5 mg/dl, calculated creatinine clearance of ≥50 ml/min by 24 hour creatinine clearance or ckd-epi. * last cycle of most recent salvage therapy within 8 weeks of enrollment * total bilirubin \< 2.0 mg/dl o if gilbert"s disease is suspected and total bilirubin \> 2.0 mg/dl, direct bilirubin must be \< 2.0 mg/dl * females of childbearing potential and males must agree to use an acceptable form of contraception per institutional practices. exclusion criteria: * disease progression by iwg working group or icml criteria since last therapy * prior autologous or allogeneic stem cell transplantation * hiv infection * comorbid condition(s) which, in the opinion of the attending physician and/or mskcc principal investigator, will preclude stem cell mobilization and/or high-dose therapy with autologous stem cell rescue * treatment plan that includes post-transplant maintenance therapy * salvage therapy that includes involved field radiotherapy

Keywords: cd34+ cell dose autologous stem cell transplantation 15-193
mindfulness and acceptance group therapy for substance use

Conditions: Substance Use Disorder

Summary: randomized clinical trial comparing standard residential substance abuse treatment to standard residential treatment plus mindfulness and acceptance group therapy for substance use.


Eligibility criteria:
inclusion criteria: * participating in inpatient substance use treatment at treatment facility exclusion criteria: * psychosis and mental impairment
patient satisfaction after root coverage using vista technique compared to mcaf technique with prf.

Conditions: Gingival Recession

Summary: vista technique with prf compared to mcaf technique with prf to treat gingival recession

comparison between two techniques for root coverage divided in two groups the first (test group) vista technique in conjunction with prf-membrane and the second (control group)mcaf technique in conjunction with prf-membrane for treating miller's class i and ii gingival recession defects. clinical periodontal records will be taken at baseline, 3 months and 6 months respectively. visual analogue scale for pain during one week after operation. patient satisfaction record using questionnaire after 6 months.

Eligibility criteria:
inclusion criteria: - age (18-55) miller's classi and ii multiple gr width of kg\>2 mm exclusion criteria: * systemic diseases poor oral hygiene smoking patient allergy miller's class iii and iv
parkinson's disease and movement disorders clinical database

Conditions: Parkinson Disease; Parkinson Disease Dementia; Lewy Body Parkinson Disease; Lewy Body Dementia with Behavioral Disturbance

Summary: the research database contains demographic and family history information, longitudinal information on the clinical symptoms, neuropsychological profile and treatments, stored biological samples, and brain images of patients with parkinson's disease and related disorders receiving care at the parkinson's disease and movement disorders center and the hospital of the university of pennsylvania.

the research database contains demographic and family history information, longitudinal information on the clinical symptoms, neuropsychological profile and treatments, stored biological samples, and brain images of patients with parkinson's disease and related disorders receiving care at the parkinson's disease and movement disorders center (pdmdc) and the hospital of the university of pennsylvania. the purpose of the research database is to have a comprehensive source of data that can be used for educational, research and patient care projects at the pdmdc. these data may be used for any study examining the relationship between treatment and clinical symptoms of patients with pd and related disorders. the main uses of the data are to: * determine the long term effects of parkinson's disease and related conditions, including predictors of its motor and non-motor symptoms * identify genetic and other neurobiological factors related to the risk of developing parkinson's disease and related disorders and their course * improve our understanding of how best to identify, diagnose, and manage motor and non-motor symptoms of parkinson's disease and related conditions evaluate biological markers of disease or response to therapy * identify patients who may be candidates for participation in trials of new medications. * identify patients who may be interested in participating in educational or developmental activities participants are seen annually for the first 4 years, biennially thereafter. the participants continue in the study until study end, withdrawal, or death on study.

Eligibility criteria:
inclusion criteria: any person who receives medical care for the diagnosis of parkinson's disease with mild cognitive impairment (mci) or dementia may be eligible to participate in the research database. there are no limitations for database participation based on age, disease severity or presence of cognitive impairments, as long as the person is able to complete the research assessments. exclusion criteria: absence of parkinson's disease diagnosis. there are no limitations for database participation based on age, disease severity or presence of cognitive impairments, as long as the person is able to complete the research assessments.
remote ischemic preconditioning before abdominal surgery

Conditions: Perioperative/Postoperative Complications

Summary: major abdominal surgeries are associated with perioperative cardiac morbidity of up to 10%. ischemic preconditioning may have a protective effect. the purpose of this study is to find out remote ischemic conditioning by inflating a blood pressure cuff on the arm will have a protective effect.


Eligibility criteria:
inclusion criteria: * patients undergoing abdominal surgery:large bowel, pancreatic and hepatic surgery exclusion criteria: * chronic inflammatory disease. * glyburide use before surgery.

Keywords: remote ischemic preconditioning abdominal surgery perioperative complications
comorbidity between balance and childhood anxiety

Conditions: Anxiety

Summary: previous studies report frequent comorbidity of anxiety and sensory-motor imbalance in adults (sklare et al., 2001). only a few studies tested the comorbidity in children. we confirmed that: a) children with primary diagnosis of poor balance demonstrate an elevated anxiety level (brat et al., 2006, submitted) and, b) children with primary diagnosis of generalized anxiety disorder demonstrate poor balance performance (erez et al., 2004). these studies demonstrate the presence of balance-anxiety comorbidity in children with primary disorder of either balance or anxiety. our theoretical reasoning formalized under the "three stage theory of learning" points to the possibility that poor balance may either predispose or cause the emergence of anxiety disorder (erez et al., 2004). thus, in the present study we test two predictions: (a) high prevalence of comorbidity of anxiety and balance disorders in children with a primary diagnosis of generalized or separation anxiety disorder, and, (b) intensive balance training, but not training of flexibility and power, will reduce the level of anxiety in children with primary diagnosis of anxiety.

study sample: 64 children, 8 to 14 years old, with diagnosis of generalized or separation anxiety. training: 32 of these children will undergo balance training and the other 32 children will undergo motor training of power and flexibility. training will last 7 weeks, twice per week, 1 hr each session. tests: balance and anxiety tests will be applied before training period, immediately after the last training session and again 2 months after the last training session. tests will include standard balance performance tests and questionnaires of anxiety.

Eligibility criteria:
inclusion criteria: * ages 8-14 * boy or girl * generalized or separation anxiety disorder * agreement to participate and written informed consent exclusion criteria: * major affective disorders * severe developmental disorders * refusal to participate

Keywords: balance disorder vestibular disorder generalized anxiety disorder separation anxiety disorder children balance training
an investigation of the dose-dependent vascualr effects of (-)-epicatechin in healthy men

Conditions: Vasodilation

Summary: aim: to investigate the dose-dependent vascular effect (primarily using fmd) of 3 low-level doses of pure (-)-epicatechin ≤ 1 mg/kg bw (0.1, 0.5 \& 1.0 mg/kg bw) in healthy men.


Eligibility criteria:
inclusion criteria: * body mass index 20-27.5 kg/m2 * normal blood pressure at screening (\< 150/90) * non-smoker * non-vegetarian * 'normal - low' chocolate consumer (\<2 potions per week) * 'normal - low' coffee/ tea drinker (\<3 cups per day) * regular exercise routine * signed consent form exclusion criteria: * haemoglobin (anaemia marker) \< 125 g/l * gamma gt (liver enzymes) \> 80 iu/l * cholesterol \> 6.5 mmol/l * suffered a myocardial infarction or stroke in the last 12 months * suffers from any cardiovascular or metabolic disorders (e.g. diabetes or any other endocrine or liver diseases) * suffers from any blood-clotting disorder, and/or takes supporting medication * any dietary restrictions or on a weight reducing diet * on any lipid-modifying or blood pressure lowering medication * consuming any specific vitamin/ herbal supplements or fish oils

Keywords: flow mediated dilatation
exercise, gut microbiota in sedentary adults with overweight

Conditions: Metabolic Disturbance

Summary: this project offers the opportunity to obtain detailed measurements on the health of body composition, metabolic health, and intestinal microbial diversity in overweight adults; moreover to provide information about the effects of physical exercise on them. the aim of the research is to advance in the understanding of the mechanisms induced by physical exercise, which includes the measurement of nutritional parameters, clinical and biochemical biomarkers of hepatic/cardiometabolic health, as well as the application of differential proteomics technologies by means of arrays of cytokines and intestinal microbiome, making this study a novel and pioneer in sensitive areas of primary health care in latin america.


Eligibility criteria:
inclusion criteria: * healthy * sedentary males * bmi\>25 kg/m2, on a stable body weight for the last 3 months exclusion criteria: * acute or chronic illness * use of antibiotics the past 2 months * smoking

Keywords: gut microbiota hepatic function obesity exercise
burn 2 learn and routine physical activity program among students

Conditions: Sports Physical Therapy

Summary: engaging in physical activity holds significant benefits for adolescents and contribute to their overall health and well-being. unfortunately, the younger generation often does not prioritize this aspect of their lifestyle. schools offer and ideal platform to actively involve and encourage our youth in regular physical activities. a total of 102 students will be selected from beaconhouse international school lahore, who will be passed through screening to fulfill the demands of the inclusion criteria. after selecting students will be randomly assigned into two groups, group a the 'burn 2 learn' group (n=51) and group b routine physical activity group (n=51). students in the 'burn 2 learn' group will participate in three sessions per week of maximum 20 minutes for 10 weeks. in contrast, students in the routine physical activity group will continue with their routine physical activity implemented within the school. evaluations of cardiorespiratory fitness using the 20m shuttle run test, wellbeing using the warwick edinburgh mental wellbeing scale and muscular fitness using the 90-degree pushup test and standing long jump test, will be taken at baseline and after 10 weeks

the 'burn 2 learn' program is a novel approach that integrates physical activity with cognitive engagement in a structured curriculum. the aim of this randomized control trial is to compare the 'burn 2 learn' program with routine physical activity on student's cardiorespiratory fitness, wellbeing and muscular fitness.

Eligibility criteria:
inclusion criteria: * students aged between 13-16 years (24) * students form grades 8 to 10 * both male and female students (24) * healthy individuals (bmi:18.5 and 24.9) (20) * students involved in mild physical activity * having playgrounds in school exclusion criteria: * students who are differently abled * sports injuries * students with co morbidities (diabetes) * connective tissue disorders * mentally retarded students * any injury in the upper or lower limb region in the past two years * neurological and musculoskeletal disorders that limit movement, and pain in the lower limb prior to and after the tests

Keywords: exercise adolescent health cardio-respiratory fitness high intensity interval training
a collaborative approach in diabetes foot education - a pragmatic randomised control trial

Conditions: Diabetes Mellitus, Type 2; Neuropathy;Peripheral

Summary: traditional directive style of requesting or demanding compliance to set behavior is found to have little effect on patient's self-care behavior. it is reported that patients prefer to restate or rephrase their understanding in a care setting, instead of a directive/didactic approach where the clinician provides 'one-way' information. in fact, directive persuasion is thought to lead to resistance to change and is counter-effective. new approaches such as open ended communication, interview style and collaborative approach is found to engage patients better in their own care and elicit patient's own intrinsic motivations for making changes. one way to do this is to 1. invite patient to share their thoughts or concerns then 2. clarify patient's understanding from their responses: (3a) affirm patient's correct understanding or (3b) address misconceptions with permission. in this study, the investigators will randomize 240 subjects into two groups: group a will undergo the above describe collaborative approach to patient education and counselling; group b will undergo current (traditional, didactic approach) patient education. it is hypothesized that the collaborative approach group (group a) should experience better understand of their health condition and foot ulcer, be better able to adhere to treatment plan through collaborative participation and overall be more satisfied with the treatment. outcomes will be tracked at (i) post intervention and (ii) 4 months post intervention.


Eligibility criteria:
inclusion criteria: 1. diagnosed type ii diabetes 2. above age 21 3. plantar foot ulcer - high risk with active full-thickness ulcer 4. pedal pulses palpable or min toe pressure of 30mmhg 5. medium of language: english 6. activities of daily living (adl) independent (without carer) exclusion criteria: 1. diagnosed mental health conditions 2. diagnosed cognitive impairment 3. diagnosed visual impairment 4. diagnosed hearing and speech disabilities

Keywords: patient education
comparison of oral molecules preventing relapses in multiple sclerosis

Conditions: Relapsing-remitting Multiple Sclerosis

Summary: the aim of this observational study is to compare dimethyl fumarate (dmf) and teriflunomide on both clinical and mri outcomes in patients with relapsing-remitting multiple sclerosis (rrms) from french observatory of multiple sclerosis (french ms cohort )


Eligibility criteria:
inclusion criteria: * rrms patients with an edss score ranging between 0 and 5.5, who initiated either dmf or teriflunomide before 1/01/2016 and with an available mri scan and edss assessment respectively within 12 and 6 months before treatment initiation patients who had consent to ofsep registry naive patient or treated with prior first line treatment : interferon, glatiramer acetate exclusion criteria: * patient with progressive multiple sclerosis * patients with prior second line patient with no mri or edss score within the year before dmf or teriflunomide initiation.
quality of life analysis in bladder pain syndrome/interstitial cystitis

Conditions: Interstitial Cystitis, Bladder Pain Syndrome, Quality of Life

Summary: the aim of our study was to evaluate whether there is a higher prevalence of anxiety-depressive disorders in women with interstitial cystitis than in women with chronic non-neoplastic pain with or without fibromyalgia, to examine possible correlations between urological and psychiatric symptoms, analyze how urological symptoms affect psychological dimension, and how specific stress or trauma can contribute to the onset of interstitial cystitis.

the survey included 69 patients, 42 patients had a diagnosis of bladder pain syndrome/interstitial cystitis while 27 of them had chronic non-neoplastic pain. the comparison of the total values of the phq-9 between the two groups, 1 versus 2, in relation to final score of phq-9, the average phq-9 score was 10.3 in group 1, therefore a value greater than 9, considered as major depression (score between 10 and 14); the average score of phq-9 was 6.9 in group 2, as in sub-threshold depression (between 5-9). correlation between phq-9 and bpi was also evaluated, the relation was significant only in interstitial cystitis with regard to the following spheres: daily life, work activity, pleasure of life, mood, sleep quality, pain intensity, and urinary symptoms. based on these data, when phq-9 score increases, and depressive symptoms worsen, there is interference with daily life and work activity, pleasure of living, mood, quality of sleep, perception of intensity of pain and urinary symptoms. patients who had onset of psychiatric symptoms following diagnosis (both interstitial cystitis and other painful syndromes) had an average phq-9 score of 11.7 compared to the score of 8.3 of patients without onset of psychiatric symptoms after diagnosis (p = 0.0464), so it may be that depressive symptoms starting after the diagnosis of pain syndrome are more severe. women who undergo psychiatric-psychological consultation and therapy have an average o'leary score 20.4 compared to 25.8 in those who are not under psychiatric consultation (p = 0.0418). this emphasizes how psychosocial support can improve perception of pain and urinary symptoms.

Eligibility criteria:
inclusion criteria: * female patients aged \> 18 years diagnosis of bps/ic or chronic non-neoplastic pain * exclusion criteria: bladder cancer -
vitamin d and preeclampsia

Conditions: Vitamin D Deficiency Defined as Serum 25OHD < 75 Nmol/l or 30ng/ml; Preeclampsia; Neonatal Hypercalcemia; Pregnancy

Summary: hypothesis : vitamin d serum concentration is decreased in the first trimester in pregnant women who will develop preeclampsia in the second or third trimester compare to a control group primary purpose : to determine the vitamin d status in the first trimester in a large population of french pregnant women in order to evaluate the importance of the vitamin d deficiency in france and correlate this deficiency with preeclampsia

primary purpose : to compare the vitamin d (25ohd) status, in the first trimester, in a group of patients with preeclampsia and a group of pregnant women without preeclampsia. secondary purpose : (i)to compare the vitamin d status in the third trimester in a group of patients with preeclampsia and a group of pregnant women without preeclampsia. (ii) to evaluate the deficit un vitamin d in a population of pregnant women in the parisian area. (iii) to evaluate the calcemia of the newborns after maternal systematic oral intake of vitamin d 100000u at 28 weeks methodology : multicenter (6 centers), cohort, nested case-control study protocol : 4500 patients will be recruited. a blood sample will be performed : in the first trimester (11-14 weeks), in the third trimester (28-40 weeks), and cord blood. for each patient with preeclampsia, 4 controls will be taken from the cohort and matched by parity, race/ethnicity, maternal age, season, bmi. the serum concentration of 25ohd will be measured in all samples.a dosage of 25ohd will be performed in 1000 women from the initial cohort in order to calculate the prevalence of vitamin d deficiency.

Eligibility criteria:
inclusion criteria: * pregnant woman * first trimester * singleton * affiliated to social security policy * woman who gave informed consent exclusion criteria: * hypercalcemia (\>2.65 mmol/l) or any other phosphocalcic disease * hypertension (\>140/90) from the first trimester * renal insufficiency (creatinine \> 120µmol/l) * bone disease (osteogenesis imperfecta...) * lithium therapy * bowel malabsorption * kidney stones

Keywords: preeclampsia vitamin d deficiency pregnancy first trimester