Kornimate/medical-research-clean huggingface dataset:
use of ultrasound for measuring size of oral tongue cancers

Conditions: Tongue SCC; Oral Cancer

Summary: the purpose of this study is to investigate the use intraoral ultrasound for measuring depth of invasion (doi) in oral tongue squamous cell carcinoma. the doi's measured on ultrasound and measurements from mri scans, will be compared to the measurements made from pathological examination of removed specimens.

the investigators will conduct a prospective cohort study to investigate the correlation between doi measurements from preoperative imaging (mri and intraoral ultrasound), and final histopathology findings. all patients with oral tongue cancer histologically verified on biopsy diagnosed in the capital region and zealand region (population 2.6 mio) are treated at the department of head and neck surgery at copenhagen university hospital (rigshospitalet). these patients will be invited to participate in the study before or at their multidisciplinary team (mdt) conference at rigshospitalet where the final treatment will be decided. the ultrasound exam is conducted with a bk5000 or bk3000 machine, a "hockey stick" x18l5s transducer or a 18l5s linear transducer. the transducer will be placed directly on the tongue tumor. the tumor size will be measured, and depth of invasion will be estimated. for later reevaluation of the ultrasound images, a sweep will be performed, and image files and video clips will be stored for documentation. patients will primarily be examined in the outpatient clinic, and the measurement will be repeated at the time of surgery when the patient is in general anesthesia. it is, however, at time of the examination outpatient clinic that the information about doi is most useful in planning the treatment, and therefore this is measurement the investigators will be focusing on. each mri scan will be reviewed by a radiologist and the doi will be assessed if possible. according to the ajcc cancer staging system, 8th edition, "doi is measured by first finding the 'horizon' of the basement membrane of the adjacent squamous mucosa. a perpendicular 'plumb line' is established from this horizon to the deepest point of tumor invasion" \[ajcc \] the investigators aim to include 30 patients in this study. the annual number of patients in our clinic operated for oral tongue carcinoma is around 50, so the investigators aim to include the 30 patients within one year.

Eligibility criteria:
inclusion criteria: * patients with squamous cell carcinoma on the lateral tongue exclusion criteria: * patients with tumor elsewhere in the oral cavity
music role in pd rehabilitation

Conditions: Parkinson Disease

Summary: neurologic music therapy (nmt) sensorimotor techniques are increasingly used to improve spatio-temporal gait parameters and postural stability in the course of parkinson's disease and following stroke. nonetheless, the neurophysiological underpinnings of nmt-mediated gait recovery is still poorly understood. the aim of the study was to investigate the central mechanisms of connectivity related to the application of rhythmic auditory stimulation (ras) in pd gait rehabilitation. the investigators will enroll 30 patients with pd. they will be randomized into two groups: (a) gait training with music; (b) conventional treadmill gait training. the experimental group will perform training by means of gt3 (biodex), where the patient is able to walk (on a treadmill) following specific musical beets and rhythms. the control group will perform only gait treadmill training. subjects will attend 3 sessions a week for at least 4 weeks. each session will last 45-min.

the aim of the study was to investigate the central mechanisms of connectivity related to the application of rhythmic auditory stimulation (ras) in pd gait rehabilitation. the investigators will enroll 30 patients with pd. they will be randomized into two groups: (a) gait training with music; (b) conventional treadmill gait training. the experimental group will perform training by means of gt3 (biodex), where the patient is able to walk (on a treadmill) following specific musical beets and rhythms. the control group will perform only gait treadmill training. subjects will attend 3 sessions a week for at least 4 weeks. each session will last 45-min. the investigators will assess the gait performance and pattern by using system bts smart for gait and the sensorimotor functional connectivity by using eeg, both before and after the therapy cycle. the patients will be clinically evaluated by means of time up and go test, and ten meters. the overall motor function will be evaluated through the updrs iii. power calculation by cohen (1992) methodology will be utilized for this pilot study. shapiro-wilk test was applied to assess the normality of distribution. thus, parametric and non-parametric tests will be employed for all comparisons (wilcoxon test, anova). mann-whitney test or anova will be utilized to evaluate the level of significance in differentiation between the examined groups.

Eligibility criteria:
inclusion criteria: * patients affected by pd; * mmse \> 21 * hoehn and yahr \<3 exclusion criteria: * presence of severe cognitive deficit * severe motor impairment (hoehn and yahr \>3) * medical illness potentially interfering with the training

Keywords: pd; gait training 3; treadmill.
impact of virtual reality on painful menstruation

Conditions: Painful Menstruation; Relaxation; Back Ligaments

Summary: to investigate the effect of virtual reality on painful menstruation in adolescent female

the focus of relatively recent work has been on non-pharmacological pain management techniques. the usage of virtual reality (vr) devices that can replicate three-dimensional (3d) immersive worlds is one particularly exciting advancement. this technology is becoming more widely available in healthcare settings and has shown promise in lowering pain and anxiety levels for people receiving minor gynecological disorders, dental work, burn wound care, and labor. so, the research purpose is targeted to look into the impact of virtual reality combined with diaphragmatic release as an active relaxation technique on painful menstruation in adolescent female

Eligibility criteria:
inclusion criteria: * age from 16 to 22 year * cases of primary dysmenorrhea * normal body mass index (20-25) exclusion criteria: * cases with polycystic ovarian syndrome * obese female or body mass index more than 25 * severe bleeding with menstruation * cases with low back pain due to orthopedic origin like disc herniation or spinal malalignment

Keywords: virtual reality diaphragmatic releasing technique painful menstruation adolescent female
the montreal neighbourhood networks and healthy aging panel

Conditions: Obesity; Depression; Physical Activity; Hypertension; Health Behavior; Subjective Health

Summary: social networks, social capital, i.e., network-accessed resources, and neighbourhood environments have been shown associated with a range of health behaviours and conditions, including obesity, physical activity, nutrition, and mental health. research on social capital and health in montreal has shown the importance of network social capital for a person's subjective health status, sense of control, self-reported physical activity, and obesity. research has also shown high social capital to reduce health service use, mental health service use, and improve the management of chronic illnesses. despite advances in the understanding of social capital and its link to health and health service use, most research on social capital is cross sectional and is unable to identify the causal pathways linking social networks and capital to health and health care use. longitudinal research would strengthen the evidence base for designing interventions to prevent or delay the use of health services, particularly in older adults. this research has three main objectives: (1) transform the original sample of montreal neighbourhood networks and healthy aging (monnet-ha) households (n=2707) into a panel study, (2) link the monnet-ha participant data to their quebec health insurance registry (régie de l'assurance maladie (ramq)) information, and (3) assess the feasibility of extending the monnet-ha panel by one wave to include participant's core network members. unique about the original monnet-ha sample is that it purposefully oversampled older adults (\> 64 years old) but remains representative of montreal adults at various ages and income levels. in addition, monnet-ha data is integrated into a gis database which allows researchers to examine the effects of neighbourhood environmental characteristics on health. by linking monnet-ha data to ramq, researchers will be able to examine patterns of diagnosed health conditions, (e.g., fractures, depression), pharmaceutical use and adherence, and formal health care use over time. transforming the cross-sectional study into a panel study would also allow researchers to examine longitudinally the dynamics of health and health care utilization among panel participants over the life course, and the causal pathways linking neighbourhoods and networks to health and health care use.


Eligibility criteria:
inclusion criteria: * adults 25 years and older, * residents of the montreal metropolitan area, canada, * had to reside at current residence for at least one year exclusion criteria: * non- french or english-speaking households * institutionalized

Keywords: social capital social support neighborhood population health healthy aging adult canada
nutritional metabolomics: the search for dietary exposure variables

Conditions: Nutrition Disorders; Metabolic Disorders

Summary: in the post-genomic era, a major challenge for health research is to understand the complex interactions among genetic, environmental and lifestyle factors including dietary intake. unfortunately, such initiatives are hampered by the lack of accurate dietary intake assessment methods for large studies. the newly emerging field of metabolomics offers unique possibilities to characterize individual food intake, dietary patterns and effects of dietary intervention in large studies. the investigators propose to develop a platform to detect broad metabolomic responses to food intake in controlled trials as well as to use targeted metabolomics approaches to characterize dietary intake in longitudinal studies. our laboratory has a long history of developing methodology for assessing nutritional status and effects of diet on metabolism. here, the investigators team up with the sahlgrenska academy core facility and the swedish nmr centre at the university of gothenburg, that offer modern metabolomics equipment and competence in bioinformatics, and use this in the context of nutrition research. to their knowledge, the investigators are among the first groups in the country to develop skills in metabolomics to assess dietary intake and effects of nutrition on metabolism, and probably the first to use two complementary platforms with both mass-spectrometry and nuclear magnetic spectroscopy. hence, our methodological results should be useful to nutritional scientists nationally as well as internationally.


Eligibility criteria:
inclusion criteria: * body mass index 18.5-30.0 * age 18-65 years old exclusion criteria: * medications or tobacco use
outcomes of patients after allo-hsct with decitabine and nac

Conditions: Engraft Failure; Relapse; GVHD

Summary: the investigators will conduct this prospective and randomized clinical trial, to evaluate the hematopoietic reconstitution, gvhd and relapse rate of patients after allo-hsct with decitabine containing conditional regimen and nac treatment.

allogeneic hematopoietic stem cell transplantation (allo-hsct) is the main curative treatment for hematological malignancy. relapse, graft versus host disease (gvhd) and graft failure are the main causes of treatment failure. acetylcysteine (nac) was found to be able to enhance defective hscs by repairing dysfunctional bone marrow endothelial cells, and overcome the exhaustion of hscs and enhance the engraftment of hscs. decitabine could restore bone marrow microenvironment by repairing endothelial cells and endothelial progenitor cells, as well as cytokines and chemokines which are crucial to hscs proliferation and differentiation, thereby promote platelet recovery after hsct. besides, decitabine therapy was shown to be associated with reduced incidence of gvhd, lower relapse rate, and increased overall survival in several studies. thereby the investigators will conduct this clinical trial to evaluate the hematopoietic reconstitution, gvhd and relapse rate of patients with hematological malignancy after allo-hsct with decitabine containing conditional regimen and nac treatment.

Eligibility criteria:
inclusion criteria: 1. diagnosed as hematopoietic malignancy; 2. achieved complete remission since the last chemotherapy; 3. age 10-70 years； 4. be willing to receive allo-hsct, with hla matched related or hla matched unrelated, or hla mismatched related donor. exclusion criteria: 1. active infections, severe organ damage (cardiac, renal and/or hepatic dysfunction greater than grade 2 according to the common terminology criteria for adverse events v5.0), or any other conditions that make patients ineligible for allo-hsct; 2. allergic to acetylcysteine or decitabine.
the effects of transcutaneous occipital nerve stimulation and instrument-assisted soft tissue mobilization on patients with chronic migraine

Conditions: Migraine

Summary: in this study, it was aimed to examine the effects of two different treatments applied to the neck region, which have been popular in recent years, on migraine.the study included 45 female patients aged 20-50 years with migraine complaints. the patients were divided into 3 randomized groups: control group (n=15), instrument-assisted soft tissue mobilization (edydm) group (n=15) and on occipital nerve tens (otes) group(n=15).each group was given home exercise to their treatment. home exercises applied 1 time per day for 5 weeks. each exercise in the exercise program was performed with 10 repetitions


Eligibility criteria:
inclusion criteria: * be between the ages of 20-50 * international classification of headache disorders, third edition (beta), using the criteria to be diagnosed with migraine without aura, * migraine with a history of being at least an annual, * vas neck pain to be on level 4, * the hit-6 score is greater than 56 exclusion criteria: * receiving pharmacological or non-pharmacological treatment regularly in the last three months, * using a pacemaker, * being an epileptic or severely psychiatric patient, * conducting a surgical operation from the neck region, * cervical disc degeneration or prolapse, the presence of different diagnoses of headaches
study of oral rucaparib with other anticancer agents in metastatic castration resistant prostate cancer patients (ramp)

Conditions: Metastatic Castration Resistant Prostate Cancer

Summary: assess the safety, tolerability, pharmacokinetics, and preliminary efficacy of oral rucaparib in combination with other anticancer agents in patients with metastatic castration resistant prostate cancer


Eligibility criteria:
inclusion criteria: * have signed an institutional review board (irb)/independent ethics committee (iec) approved informed consent form prior to any study-specific evaluation * be ≥18 yrs of age at the time the informed consent form is signed * be either ar-directed therapy-naive or have received 1-2 lines of ar-directed therapy in the castration-resistant setting. * adequate organ function * ecog 0 or 1 * have a histologically or cytologically confirmed adenocarcinoma or poorly differentiated carcinoma of the prostate that is metastatic * be surgically or medically castrated, with serum testosterone levels of ≤ 50 ng/dl (1.73 nm) * have disease progression after initiation of most recent therapy exclusion criteria: * active second malignancy, with the exception of curatively treated non melanoma skin cancer, carcinoma in situ, or superficial bladder cancer * have received greater than 2 previous lines of chemotherapy for mcrpc * prior treatment with any parp inhibitor * symptomatic and/or untreated central nervous system metastases * pre-existing duodenal stent and/or any gastrointestinal disorder or defect that would, in the opinion of the investigator, interfere with absorption of study drug * spinal cord compression, symptomatic and/or untreated central nervous system (cns) metastases or leptomeningeal disease. patients with asymptomatic previously treated cns metastases are eligible provided they have been clinically stable for at least 4 weeks * any clinically significant cardiovascular disease * taking any concomitant medications or herbs that could interfere or interact with the study drug

Keywords: crpc parp inhibitor ramp homologous recombination dna repair dna defect dna anomaly mcrpc enzalutamide abiraterone zytiga xtandi adt ar ari
high cut off dialysis in systemic inflammatory response syndrome patients after cardiac surgery

Conditions: Systemic Inflammatory Response Syndrome; Acute Kidney Injury

Summary: a high cut off dialyzer (septex) is tested in patients after cardio-thoracic surgery with incidence of "systemic inflammatory response syndrome" (sirs) and associated increased risk for acute kidney injury (aki). hypothesis: the high cut off dialyzer (septex) can increase the postoperative il-6/il-10 ratio.

cardiac surgery associated systemic inflammatory response syndrome (sirs) plays an important pathophysiological role in the development of aki in patients after cardiothoracic surgery. previous studies have shown that the elimination of inflammatory mediators can be either achieved by continuous venous venous hemodialysis(cvvhd) or continuous venous venous hemofiltration (cvvh) by using a high-cutoff (hco) membrane with a cut-off 45kd. data from patients treated with hco-cvvhd during septic shock show a reduction in systemic cytokines and improved hemodynamics. no data about the effects of early hco-cvvh in cardiac surgery patients with a high risk of cardiac surgery associated aki and consequently a high rate of postoperative renal replacement therapy (rrt) are available. it is of note that patients with euroscore \> 6 are on high risk to develop sirs associated aki. no pharmacological anti-inflammatory approach has convincingly shown to prevent renal dysfunction in these patients.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * scheduled for complex / prolonged cardiac surgery (i.e.combined cabg+ valve surgery, redo surgery) with an anticipated cpb time \> 120 min * ckd with an e gfr \< 50ml/min/m2 * euroscore \> 6 exclusion criteria: * end stage ckd (dialysis dependent) renal failure before surgery * radiocontrast exposure within 24 hours before surgery * active endocarditic with antibiotic treatment * pulmonary disease with chronic hypoxia * clinically significant liver dysfunction (bilirubin \> 1.8mg/dl (30µmol/l)) * known hiv, hcv infection * alcoholism * active uncontrolled infection * pregnancy or lactation * inability to give informed consent to participate in the study

Keywords: septex high cut-off thoracic surgery renal replacement therapy
pharmacist for detecting opioid misuse

Conditions: Chronic Non Cancer Pain

Summary: opioid use is increasing in western countries and is associated with harms as hospitalization, addiction and deaths(1). community pharmacists interact frequently with patients, giving them the opportunity to identify and prevent the risk of prescribed opioid misuse. the purpose of this study was therefore to assess the risk of prescribed opioids misuse in ambulatory patients with chronic non-cancer pain (cncp) seen in community pharmacies. method: a questionnaire (including the prescription opioid misuse pomi(2)) have been proposed to patients with opioid prescription by pharmacy students, in 86 pharmacies of occitanie-est, in april 2019. eligible patients were adults with cncp that consented to participate. a total of 414 patients (62.4% women, mean age 58 ± 16.00) have been included. the main pains were spinal (37.3%) and osteoarticular (33.1%). the median visual analog scale (vas) was 7 \[iqr25-75: 5-8\]. the prescribed opioids are mainly weak opioids (73.2%): paracetamol/tramadol (35%), paracetamol/codeine (17.4%), paracetamol/opium (16.8%). strong opioids (32.6%) were oxycodone (11.95%), fentanyl (9%), and morphine (9%). the median morphine milligram equivalent (mme) was 40 mg/day \[iqr25-75: 20-80\]. pomi score was superior to 2/6 in 45.4% and superior to 4 in 16%. the main positive question were feel high (40.3%), take the opioid more often (39.3%), take more medication (36.6), and need to early renew opioid medication earlier (30.8%). patients with pomi score \> 4 were younger (49 years versus 55.9; p\<0.01), more urban (78.1% versus 69.2%; p=0.03), had higher vas (7.3 versus 6.2; p\<0.01), received higher median mme (112 mg versus 64.9 mg; p\<0.01), and consumed more strong opioid (45.3% versus 27.3%; p=0.04).


Eligibility criteria:
inclusion criteria: * -collection of the questionnaire in a community pharmacy of the area of investigation east-occitania) * patient over 18 years of age * suffering from pain (cncp) (\> 3 months old) * treated with weak or strong opioids exclusion criteria: * collection of the questionnaire in a community pharmacy outside eastern occitania * patient under 18 years of age * suffering from acute pain (\< 3 months old) or cancerous pain

Keywords: opioid misuse community pharmacy pomi test
effects of exercise behavior modification on plasma adiponectin and insulin resistance in high risk subjects of diabetes

Conditions: Diabetes Mellitus

Summary: investigators hypothesized home-based exercise intervention was beneficial to those who have had diabetic risk factor for type 2 diabetes mellitus

this randomized clinical trial was designed to investigate whether a home-based exercise could improve adiponectin levels, exercise behavior and metabolic risk factors (insulin resistance, metabolic components and physical fitness) in subjects with at least a diabetic risk factor for type 2 diabetes mellitus. participants were randomly allocated to either a control group or a home-based exercise group. all participants were evaluated for outcome measures at baseline, and at 3-month 6-month and 9-month follow-up after engaging in the intervention.

Eligibility criteria:
inclusion criteria: * at least one of the following criteria as following: bmi \>=24 kg/m\*m, hypertension, dyslipidemia, fist-degree relatives of parents with type 2 diabetes, impaired glucose tolerance, gestational diabetes and delivering a babt weighing \>=4.0 kg * ability of understanding chinese or taiwanese exclusion criteria: * diabetes * receiving treatment with insulin or oral hypoglycemic agents * any other serious illness that prohibit them to undertake fitness evaluation

Keywords: diabetes physical activity adiponectin metabolic risks exercise primary prevention