Kornimate/medical-research-clean huggingface dataset:
changes in perception and cognition during a meditation retreat

Conditions: Healthy Volunteers

Summary: this study aims at assessing neuro-behavioral changes occuring during an intensive ten days meditation retreat. the investigator will study changes in tactile, auditory and pain perceptions as well as changes in cognitive and affective mental contents and their neural markers, as measured by self-reports, eeg event-related potentials, and functional connectivity of resting state fmri. he will recruit healthy participants with a prior meditation experience. they will be randomly assigned to two groups, one active group who will undergo measurements just before, during and 3 weeks after the retreat. the other group will serve of control for task habituation, control participants will undergo the same measurements, equally spaced in time, but before the retreat. the main hypothesis is that meditation training strengthens meta-awareness, attention capacities resulting in enhanced bodily- and self-awareness during sensory perception and emotion regulation during pain.


Eligibility criteria:
inclusion criteria: * age between 18 and 67 * regular meditation practice (at least 20 minutes 3 times a week) arising from a formal teaching (buddhist tradition, mbsr, mindfulness) for at least one year. * having taken part to at least one intensive retreat (more than six hours of sitting meditation a day, during at least two days) in the past. * affiliated to french social security * motivated to take part in the study * having signed an informed consent * normal or corrected vision * sufficient mastering of french to be able to understand correctly written and auditory instructions exclusion criteria: * neurological or psychiatric antecedents * chronical pain or any other medical condition giving rise to acute pain or sensitivity to pain. * motor or sensory deficit in the hands * severe auditory loss * regularly taking medical drugs acting on the central nervous system * regularly taking opioids or antidepressant drugs * alcohol consumption above the safety threshold recognized by the french healthy agency (10 drinks a week, 2 drinks a day, 5 drinks for special occasions) * drugs consumption (except tabacco) qualified as addictive according to medical criteria (https://www.drogues.gouv.fr/comprendre/l-essentiel-sur-les-addictions/qu-est-ce-qu-une-addiction) * alcohol or drug consumption the day before or the day of experiment and during the full duration of the retreat * being pregnant, breastfeading or having given birth less than 6 months ago * will be excluded from the fmri task only, participants presenting contraindication to a mri scan : being claustrophobic, body mass index over 30, people, having a pacemaker or an insuline pump, metallic prothesis, intracranial clip, neurosensory stimulator, in-body defibrillator, cochlear implants, ocular or brain feromagnetic bodies close to nervous structures, neurosurgery stunts, dental brace.

Keywords: meditation emotional regulation metacognitive awareness attention mindfulness pain predictive coding
it is a prospective study aiming to identify incidence and prevalence of cardiovascular diseases, changes in physical activity, dietary habits and anxiety depression levels through a period of time in the naval personnel (prospective hellenic naval personnel study in cardiovascular diseases)

Conditions: Cardiovascular Diseases; Risk Factor, Cardiovascular

Summary: prospective study. starting from 2014 all newly appointed 1st year cadets in naval academies will be enrolled until the class of 2025. physical examination, food frequency questionnaire, physical activity questionnaire, anxiety/depression questionnaire, medical history will be filled out at first interview. specific blood tests will be performed. every participant will be interviewed every three years and will complete the same questionnaires. follow up period is determined ten years after last class enrollment


Eligibility criteria:
inclusion criteria: - exclusion criteria: * non signed consent form
stereotactic radiosurgery in treating patients with large brain metastases

Conditions: Tumors Metastatic to Brain; Unspecified Adult Solid Tumor

Summary: this phase i/ii trial studies the side effects and the best dose of stereotactic radiosurgery and to see how well it works in treating patients with large brain metastases. radiosurgery can send x-rays directly to the tumor and cause less damage to normal tissue.

primary objectives: i. to determine the incidence of acute and long-term toxicities with increasing dose of stereotactic radiosurgery (srs). (phase i) ii. to determine if local control may be improved with increasing doses of srs. (phase ii) secondary objectives: i. to determine the risk of acute and long-term toxicity with increasing dose of srs. (phase ii) ii. to determine if there is increased neurocognitive toxicity with increased dose of srs. iii. to determine the rate of radiation necrosis/steroid dependency. iv. to determine if quality of life is affected more by tumor recurrence versus radiation necrosis. this includes assessment of progression free survival, overall survival, local failure, and number of patients who receive bevacizumab, laser interstitial thermal therapy, or surgery for presumed radiation necrosis. outline: this is a phase i dose-escalation study followed by a phase ii study. patients undergo srs guided by computer tomography (ct) and magnetic resonance imaging (mri). after completion of treatment, patients are followed up at 1-2, 3, 6, 9, and 12 months, every 3 months for 2 years, and then every 4 months thereafter.

Eligibility criteria:
inclusion criteria: * any patient undergoing srs for brain metastases * lesions to be treated under this protocol must be \> 2 cm, but =\< 4.0 cm in diameter * patients may have had prior therapy including: * whole brain radiation therapy (wbrt) \> 3 months ago * srs to other brain metastases * patients with newly diagnosed brain metastases are eligible as long as they are not planned for wbrt upfront * any primary is eligible with exception of small cell lung cancer, lymphoma, and germ cell histologies * patient must be able to provide written informed consent exclusion criteria: * patients receiving srs to resection bed * planned concurrent wbrt * leptomeningeal metastases * small cell lung cancer, lymphoma, and germ cell histologies * inability to participate in study activities due to physical or mental limitations * inability or unwillingness to return for all the required follow-up visits * conformality index 2.0 or less cannot be achieved, or homogeneity index is \> 2.0 * unable to deliver 10 gray (gy) or less to optic nerve/chiasm * brainstem location is excluded from this study

Keywords: unspecified adult solid tumor, protocol specific
effect of back school and supervised walking in sedentary women with chronic low back pain

Conditions: Chronic Low Back Pain

Summary: do back school and/or supervised walking improve reported pain and spine flexibility in sedentary women with chronic low back pain (lbp)?

from august 2002 to march 2004, one hundred nineteen volunteers sedentary women with chronic lbp and age ranging from 32 to 60 years old, randomly allocated to four groups of participants assigned as back school (bs; n=28), supervised walking (w; n=32), back school and supervised walking (bs+w; n=29), and control group (cg; n=30) were submitted to interventions once a week for 5 consecutive weeks and followed for up to 6 months. the groups bs, w, and bs+w received lbp-targeted lectures and on-place practical sessions of each respective intervention. cg received print information about lbp and 5 different lectures unrelated to lbp.

Eligibility criteria:
inclusion criteria: * age range 30 to 60 years old * lbp without any known organic cause for at least 3 months of duration * less than 90 minutes per week of regular physical activity of any intensity exclusion criteria: * any known organic cause of lbp

Keywords: chronic low back pain back school walking physical activity
magnetotherapy in rheumatoid arthritis treatment

Conditions: Rheumatoid Arthritis; Hand Rheumatism

Summary: participants with rheumatoid arthritis with recommendation to physiotherapy. created 3 study groups: 1. only kinesiotherapy 2. kinesiotherapy with unipolar magnetic field 3. kinesiotherapy with bipolar magnetic field kinesiotherapy with magnetic field give better effects than only kinesiotherapy.

participants with rheumatoid arthritis with recommendation to physiotherapy. all participants have dysfunction and pain of hand. inclusion criteria: 1. ii ° and iii ° of advancement of radiological changes 2. ii ° and iii ° of advancement of functional changes 3. remission, low or moderate ra activity: das28 4. medical order 1. magnetotherapy and kinesiotherapy 2. kinesiotherapy 3. consent to participate in the study 4. completion of the research program exclusion criteria: 1. additional physiotherapy treatments for the hands 2. change in type or dose of pharmacotherapy used 3. taking steroid anti-inflammatory drugs 4. malaise and side effects in the subject outcome measures: 1. duration of morning stiffness 2. the degree of severity of morning stiffness 3. pain intensity assessment (vas) 4. test box \& blocks 5. measurement of the palmar surface of the hand 6. measuring the range of motion in the joints of the hand 7. measurement of compression force in a cylindrical grip 8. time to maintain maximum pressure during cylindrical grip 9. hand volume measurement 10. haq-20 test intervention: 1. group 1: only kinesiotherapy 2. group 2: kinesiotherapy with bipolar magnetic field 3. group 3: kinesiotherapy with unipolar magnetic field assessment: 1. immediately before start therapy 2. immediately after therapy (10 treatments in 2 weeks)

Eligibility criteria:
inclusion criteria: * ii ° and iii ° of advancement of radiological changes * ii ° and iii ° of advancement of functional changes * remission, low or moderate ra activity: das28 * medical order * magnetotherapy and kinesiotherapy * kinesiotherapy * consent to participate in the study * completion of the research program exclusion criteria: * additional physiotherapy treatments for the hands * change in type or dose of pharmacotherapy used * taking steroid anti-inflammatory drugs * malaise and side effects in the subject

Keywords: magnetotherapy rheumatoid arthritis hand function
the multifunctional image guided therapy suite (migts) in emergency multiple trauma care

Conditions: Acceleration of Procedure; Reduction of Number of Transports and Transfers; Involved Staff Member's Evaluation

Summary: controlled clinical intervention study comparing the treatment of multiple trauma patients in a newly developed combined diagnostic and operation room, the multifunctional image guided therapy suite (migts) versus controls. the migts proved to significantly accelerate the procedure and led to more satisfied team members.

objective: pilot evaluation to which extend the implementation of a newly developed combined diagnostic and operation room, the multifunctional image guided therapy suite (migts) may influence the emergency treatment of multiply injured patients. summary background: controlled data on the impact of modern technology integration in multiple trauma management and involved care providers are lacking. methods: quasi-randomized clinical intervention study comparing the treatment of multiple trauma patients (injury severity score, iss \>16) in the migts versus controls.

Eligibility criteria:
inclusion criteria: * multiple trauma with * at least two abbreviated injury scoring (ais) regions involved and * injury severity score (iss)\>16 * primary hospital treatment at university hospital basel exclusion criteria: * monotrauma or * iss \< 16 or * prior treatment in another hospital

Keywords: multiple trauma outcome and process assessment
long-term safety study of canagliflozin (ta-7284) in combination with insulin in patients with type 2 diabetes mellitus

Conditions: Type 2 Diabetes Mellitus

Summary: this extension study was designed to evaluate the safety and efficacy of canagliflozin (ta-7284) in combination with insulin in patients with type 2 diabetes mellitus. the extension study was an extension to double-blind study of 16 weeks (ta-7284-11)

this is an open-label extension study to evaluate the safety and efficacy of canagliflozin (ta-7284) in combination with insulin in japanese patients with type 2 diabetes mellitus, who are not optimally controlled on diet and exercise. the patients will enroll from the double-blind study of 16 weeks and receive ta-7284 100mg orally for 36 weeks.

Eligibility criteria:
inclusion criteria: * patients should complete the week 16 assessments in the double-blind study (ta-7284-11) exclusion criteria: * patients with hereditary glucose-galactose malabsorption or primary renal glucosuria * patients with severe diabetic complications (proliferative diabetic retinopathy, stage 4 nephropathy, or serious diabetic neuropathy) * patients with serious renal or hepatic disease * patients who are the excessive alcohol addicts * patients who are pregnant, lactating and probably pregnant patients and patients who can not agree to contraception

Keywords: insulin resistance
msct angiography in bleeding

Conditions: Lower Gastrointestinal Bleeding

Summary: lower gastrointestinal bleeding occurs distal to the ligament of treitz and may involve the small bowel, colon and rectum . active lower gastrointestinal bleeding is a common, potentially life threatening medical presentation that can be challenging to localize and treat . there are many diseases that may cause lower gastrointestinal bleeding, including angiodysplasia, diverticulosis, benign or malignant bowel neoplasm, inflammatory bowel disease, ischemic bowel disease, and infectious bowel disease. often, gastrointestinal bleeding will stop spontaneously, but in approximately 25% of patients, bleeding is massive or recurrent, requiring imaging localization and directed therapy.

accurate and prompt diagnosis of the bleeding source is crucial because mortality can be as high as 40%if there is hemodynamic instability in patients . because of the length of gi tract, the multitude of pathologic processes that can result in gi bleeding, imaging plays a primary role in the diagnosis . multislice ct angiography (mscta) provides a relatively non-invasive and effective way of localising the source of bleeding, especially in patients with continuous bleeding . mscta is being increasingly used because it is a widely available, non-invasive and fast diagnostic technique that allows for the visualization of the entire intestinal tract and its lesions, the identification of the vascularity and possible vascular abnormalities. in addition, this technique does not require preparation in patients with acute bleeding.

Eligibility criteria:
inclusion criteria: * patients presenting to assiut university hospital with active lower gastrointestinal bleeding. exclusion criteria: * patients whom are sensitive to contrast. pregnant women. patients with renal insufficiency
colchicine for the prevention of vascular events after an acute intracerebral hemorrhage

Conditions: Intracranial Hemorrhages

Summary: the overall goal is to establish the safety and efficacy of colchicine in ich patients for the prevention of major cardiovascular events and brain injury. colchicine for the prevention of vascular events after an acute intracerebral hemorrhage (covasc-ich) is a vanguard pilot trial designed to obtain the factual feasibility prerequisites essential for the planning, design, funding and execution of a subsequent phase iii trial.


Eligibility criteria:
inclusion criteria adult participants are eligible to be included in the study only if all of the following criteria apply: type of participant and disease characteristics 1. participants with documented spontaneous intraparenchymal hemorrhage within 48 hours of symptom onset (or last seen normal) and 2. qualifying for at least one of the following categories: i. history of symptomatic coronary, peripheral and/or carotid artery disease (severe atherosclerotic vascular disease), or ii. visualized extracranial cervical/intracranial atherosclerotic disease causing any degree of stenosis/occlusion or presence of aortic arch plaque with maximum thickness ≥1 mm (moderate atherosclerotic vascular disease), or iii. two or more risk factors including: age 60 years or older, hypertension, dyslipidemia, diabetes mellitus, chronic kidney disease (egfr: 15-50ml/min), history of ischemic stroke or current smoking (mild atherosclerotic vascular disease) informed consent 3. capable of giving signed informed consent either independently, or by a legally authorized representative (lar), which includes compliance with the requirements and restrictions listed in the informed consent form (icf) and in this protocol. exclusion criteria participants are excluded from the study if any of the following criteria apply: medical conditions 1. secondary causes of ich (relating to trauma, macrovascular anomalies, neoplasms or bleeding diathesis) 2. inflammatory bowel disease or chronic diarrhea 3. cirrhosis or severe hepatic dysfunction 4. renal insufficiency (egfr \<15ml/min) prior/concomitant therapy 5. concurrent treatment with strong cyp3a4 inhibitors (atazanavir, clarithromycin, darunavir/ritonavir, indinavir, itraconazole, ketoconazole, lopinavir/ritonavir, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, tipranavir/ritonavir) or p-gp inhibitors (cyclosporine, ranolazine) 6. known allergy or sensitivity to colchicine 7. strong indication for colchicine where assignment to placebo is deemed unacceptable other exclusions 8. pregnant or breast-feeding 9. inability to adhere to study procedures 10. estimated life expectancy less than 6 months at the time of enrollment 11. close affiliation with the investigational site; e.g. a close relative of the investigator, dependent person (e.g., employee or student of the investigational site)

Keywords: intracranial hemorrhage colchicine
cad-cam or adhesive approaches for mih treatment

Conditions: Molar Hypomineralization; Dental Restoration Failure of Marginal Integrity

Summary: aim: this randomized controlled clinical study aimed to compare direct composite resin restorations and computer aided design-computer aided manufacturing (cad-cam) supported inlay or onlay restorations in young permanent molar teeth with hypomineralization. the main questions aim to answer are: * the clinical success rate of cad-cam supported restorations * the highest clinical success rate for restoring hypomineralized teeth. materials and method: children aged 6-14 years old without any systemic conditions with 32 first and second hypomineralized permanent molar teeth were included in the study. patients were randomly distributed into 2 groups as direct composite resin restorations and cad-cam supported inlay or onlay restorations. all restored teeth were evaluated clinically and radiographically for 24-months. statistical significance was accepted as p\<0.05.

after randomization and local anesthesia administration, caries removal and preparation were completed under rubber-dam isolation. after preparation, 60 seconds of orthophosphoric acid, 60 seconds of 5% sodium hypochlorite and 30 seconds of orthophosphoric acid steps were applied before bonding agent and composite resin restorations. on the other hand, the preparation was completed by making a bevel on the enamel surfaces and a nanohybrid ceramic material used for the manufacturing cad-cam supported inlay or onlay restorations.

Eligibility criteria:
inclusion criteria: * patients with first and second permanent molar teeth that have loss of more than one surface due to hypomineralization and seen with white, brown, or yellow opacities on anterior permanent teeth * patients without any systemic, physical, physiological, or allergic conditions exclusion criteria: * patients who had symptoms during the follow-up periods * patients who did not attend follow-up appointments

Keywords: molar incisor hypomineralization cad-cam supported restoration composite resin restoration
risk factors and machine learning model for proton pump inhibitor related acute kidney injury

Conditions: Proton Pump Inhibitor; Acute Kidney Injury

Summary: recent evidence concerns acute kidney injury (aki) following proton pump inhibitor (ppi) application. few actual studies have compared the incidence, risk factors, and predictive models of aki associated with ppi. the present study was a single-center retrospective study. the researchers retrospectively analyzed data from patients who received ppi medications between january 2018 and december 2020. ppi drugs included omeprazole, esomeprazole, rabeprazole, and pantoprazole. the primary outcome of the study was aki, as defined by kidney disease: improving global outcomes (kdigo). secondary outcomes included length of hospital stay, hospital costs, and continuous renal replacement therapy. independent risk factors associated with aki were identified by univariate analysis and multifactorial logistic regression analysis (p \< 0.05). logistic regression models were constructed based on the variables obtained from the analysis. internal validation of the model was performed by the ten-fold cross-validation method. model discriminatory power was assessed by the area under the curve (auc) of the receiver operating characteristic curve (roc). the study aims to develop a ppi-related aki prediction model based on an electronic medical record system that can be used to predict aki in hospitalized patients and contribute to the early prevention, diagnosis and treatment of aki, ultimately reducing morbidity and improving prognosis.


Eligibility criteria:
inclusion criteria: * all inpatients who used proton pump inhibitor during hospitalization * hospital stay ≥ 48h * age ≥18 years * there are two or more blood creatinine tests during hospitalization exclusion criteria: * hospital stay \< 48h * age \<18 years * glomerular filtration rate (gfr)\< 30ml/min/1.73m2 within 48 hours after admission * aki was diagnosed on admission * less than two scr test results during hospitalization * the scr values were always lower than 40 μmol/l during hospitalization * cases with incomplete medical history information

Keywords: proton pump inhibitor acute kidney injury pharmacoepidemiology miss diagnosis risk factors logic regression
asthma in the delta region of arkansas (adra): prevalence and morbidity

Conditions: Asthma

Summary: the purpose of the study is to conduct a cross-sectional study to examine asthma prevalence and morbidity in a predominately minority, low-income population in rural arkansas.

asthma is the leading chronic disease of childhood in the united states and an important public health concern in arkansas. arkansas, a predominately rural state, has one of the leading mortality rates in the nation for african americans. the specific aims of the study will examine asthma prevalence in children age 4-17 years old in public schools in eudora and marvell arkansas. the study will also examine asthma morbidity among identified asthmatics by characterizing activity limitation, days missed from school, daytime and nocturnal symptoms, healthcare utilization and medication use. the specific aims of the current study will provide novel data on an understudied population of asthmatics and will test our working hypotheses that pediatric asthma prevalence in the delta region of arkansas is higher than national estimates; and asthma diagnosis is related to significant morbidity among rural asthmatics.

Eligibility criteria:
inclusion criteria: * children aged 4-17 years, enrolled in the public schools in eudora and marvell arkansas. exclusion criteria: * children aged 18 or older enrolled in the public schools in eudora and marvell arkansas were excluded.

Keywords: asthma; minority; low-income; african american; arkansas