Kornimate/medical-research-clean huggingface dataset:
using self-evaluation to increase visit intervals in juvenile idiopathic arthritis

Conditions: JIA; Self-Evaluation

Summary: in the thuis study, jia patients in clinical remission will skip one 3-monthly hospital control visit and instead monitor their disease activity at home. outcomes at 6 months will be compared to those from a historical cohort.

background: children with juvenile idiopathic arthritis (jia) commonly visit their pediatric rheumatologist every 3 months. this costs time and money for the patient, their parents or guardian, the hospital and other stakeholders. therefore, the thuis study aims to demonstrate that jia patients in clinical remission can safely increase their visit interval by home-monitoring disease activity using the euroqol five-dimensional youth questionnaire with five levels (eq-5d-y-5l) and juvenile arthritis multidimensional assessment report (jamar). methods: jia patients in remission from the wilhelmina children's hospital in utrecht, the netherlands, will skip one 3-monthly control visit and instead complete an online eq-5d-y-5l and jamar questionnaire at home. the home-monitoring results will be evaluated by a research nurse in consultation with the treating pediatric rheumatologist in order to determine if the patient can safely remain at home or has to be planned in for a short-term control visit at the hospital. primary and secondary outcomes after 6 months will be compared with a historical cohort of matched jia patients in order to prove non-inferiority.

Eligibility criteria:
inclusion criteria: * jia diagnosis of ≥1 year, all subtypes can participate * clinical remission, defined as a cjadas of ≤3 exclusion criteria: * insufficient control of the dutch language * not able or willing to use e-mail

Keywords: juvenile idiopathic arthritis remote monitoring e-health patient-reported outcomes disease activity healthcare costs non-inferiority trial
non-adherence and polypharmacy in elderly patients

Conditions: Adherence

Summary: the study aims to investigate adherence and polypharmacy in elderly patients with chronic kidney disease (ckd) and end stage renal disease (esrd). the investigators look into possible factors or predictors that may affect adherence and reduce polypharmacy. factors could be: quality of life, anxiety and depression, beliefs about medicine and cognitive impairment. the investigators are planning an intervention with the screening tool screening tool of older person's potentially inappropriate prescription/screening tool to alert to right treatment (stopp/start ) criteria to evaluate medication lists of the participating patients.

the investigators intend to include all patients \> 65 years old, in dialysis treatment (hemodialysis and peritoneal dialysis), as well as patients with ckd stage 5. the recruitment will be done as follows: the patients will be screened according to inclusion criteria. afterwards each patient will be invited to a first meeting that explains the aim of the study, giving the opportunity for discussion and consideration, and presenting the consent information. after giving the consent the patient will be invited to a second meeting with blood tests, data registration, medication registration, undergoing mms and handing over the questionnaires forms. randomization: after the initial assessment and compliance with the eligibility criteria, participants will be randomized into an intervention group (medication list will be evaluated by stopp/start criteria) and a control group (medication list will not be evaluated by stopp/start criteria). randomization numbers will be generated by a random number generator. a series of numbered, sealed, opaque envelopes will be used to ensure confidentiality. each envelope will contain a card with information about the group allocation. the group allocation is concealed from the researcher and patients at baseline registration. each patients will get questionnaires for: quality of life using kidney disease quality of life - short form 36 (kdqol-short form 36 ) and euroqol-3d (eq-3d), beliefs about medicine, hospital anxiety and depression scale (hads), morisky medication adherence scale and visual adherence scale (vas), sleeping related questionnaires (epworth, berlin, pittsburgh). a mini mental status (mms) test will be done regarding cognitive function. each patients will get the opportunity to have a polysomnograph for one night. with stopp/start criteria the medication list will be evaluated for the patients who are randomized in the intervention group.

Eligibility criteria:
inclusion criteria: * all patients \> 65 years with ckd, stage 5 (egfr ≤ 12 ml/min), or undergoing treatment with hemodialysis and peritoneal dialysis exclusion criteria: * patients not willing to participate * patients diagnosed with dementia or severe cognitive disorder (mms \< 25), * patients with hearing impairment * patients with language difficulties

Keywords: adherence polypharmacy elderly chronic kidney disease
intravenous lidocaine for post-tonsillectomy pain in pediatric patients

Conditions: Pain

Summary: the purpose of this study is to determine whether giving lidocaine intravenously during and after a tonsillectomy surgery is effective in decreasing postoperative pain.

the purpose of this study is to determine whether giving lidocaine intravenously during and after a tonsillectomy surgery is effective in decreasing postoperative pain when compared to placebo. participants will be in one of two arms. those in arm 1 will receive a lidocaine bolus and infusion throughout the initial recovery period while those in arm 2 will receive an equal volume of normal saline. subjects will be monitored and assessed for pain during their time in the hospital and followed up on at home for a week after the surgery. primary outcomes will be measure of pain. secondary outcome measures will include pain medication use, emergence delirium, incidence of laryngospasm, and side effects.

Eligibility criteria:
inclusion criteria: * scheduled for tonsillectomy (with or without adenoidectomy) with dr. kathleen billings or dr. stephen hoff at lurie children's hospital * american society of anesthesiology (asa) patient classification i-iii (healthy patient to a patient with mild systemic disease) exclusion criteria: * physical or developmental delays * psychiatric illness * current use of sedative or anticonvulsant medications * pre-existing renal disease (ranging from stage 2 \[mild\] to stage 5 \[end stage\]) * pre-existing cardiovascular disease (including, not limited to congenital heart disease or arrythmia) * pre-existing liver disease * pre-existing cerebral or neuromuscular disease * patient or family history of malignant hyperthermia * recent history of upper respiratory infection within last 7 days * regular use of analgesic medication * diagnosis of severe obstructive sleep apnea requiring overnight stay for observation * other procedure scheduled in addition to tonsillectomy * history of allergies to local anesthetics
influence of laminoplasty and internal fixation on vertebral stability after laminectomy

Conditions: Disorders Following Clinical Procedure

Summary: the lesion located inside the spinal canal caused big trouble for clinical treatment. traditional laminectomy will destroy the biomechanics and influent the vertebral stability, which might cause kyphosis or other deformity. so in some centers, neurosurgeries praised laminoplasty to make the intactness of posterior column. they thought the laminoplasty can maintain the vertebral stability, and meanwhile the range of motion won't change so much. however, some other scholars thought laminoplasty had no helps for stability because of the pseudarthrosis. they preferred screw and stick system for internal fixation. and we did meet several patients after laminectomy suffered with spinal deformity. so we thought it is necessary for investigating the benefit of patients from laminoplasty and internal fixation.

after laminectomy for removal of the cervical, thoracic and lumbar lesions, the recruited cases were randomly divided into two groups. 1. the cases in group of laminoplasty, the lamina and spinous process was replanted to maintain the anatomical intactness of spinal canal. 2. on the other hand, the cases in internal fixation group, the pedicle screws were implanted, and tickets were used to complete the internal fixation. during 3 years follow up, the vertebral deformity and the range of motion were investigated and evaluated. and in the meantime, the patient's age will also be analyzed to detect it's influence for the prognosis.

Eligibility criteria:
inclusion criteria: - 1. adult patients (\>=18 years) were enrolled. 2. the patients suffered with lesion inside the spinal canal, who underwent laminectomy to remove the lesion. 3. pathology proved benign lesion. 4. health condition of patients (kps) \>= 70. exclusion criteria: * 1. children cases (\<18 years) were excluded. * 2.the cases with pathological malignant tumors were excluded from this study. * 3. kps of patients \< 70.

Keywords: laminectomy laminoplasty internal fixation deformity
effects of functional kinesio taping on subacromial space in athletes with rotator cuff tendinopathy

Conditions: Sports Physical Therapy

Summary: to determine the effects of functional kinesio taping on subacromial space in athletes with rotator cuff tendinopathy.

subacromial impingement is a condition among athletes those involved in overhead sports activities such as swimming and volleyball. according to neer there are two main categories of shoulder impingement, these are structural and functional. structural: caused by reduction of the subacromial space (sas) due to bony growth, calcification or soft tissue inflammation whereas functional is caused by or superior migration of the humeral head due to muscular weakness imbalance. in some cases subacromial impingement can be result from a combination of both structural and functional factors.maintenance of the sas during arm elevation is thus essential for the prevention of rotator cuff tendinopathy. the aim of this randomized controlled trial (rct) is to evaluate the long-term effects of scapular kt, added to a 6-week rehabilitation program, on the subacromial space at different arm positions in athletes with rotator cuff tendinopathy. to better understand the underlying mechanisms of kt, our secondary objective addressed the effects of kt on reliving pain-free and full rom of shoulder joint.

Eligibility criteria:
inclusion criteria: * age between 18 to 35 years * both gender * athletes participating in volley ball, tennis, badminton and golf. * presence of shoulder pain in abduction and external rotation during training for more than three months * three out of five positive results for the following: painful arc, pain or weakness with resisted external rotation, abduction, neer test, hawkins kennedy test, empty can test/jobe test exclusion criteria: * h/o shoulder fractures, * instability or dislocation (positive apprehension and relocation tests) * frozen shoulder (all stages) * recent shoulder surgery for a shoulder injury
a comprehensive smoking cessation intervention duration radiation for upper aerodigestive cancers

Conditions: Tobacco Use Disorder; Head and Neck Neoplasms; Thoracic Neoplasms; Radiation

Summary: smoking is the greatest risk factor for upper aerodigestive cancers (thoracic or head and neck) and negatively impacts survival and other outcomes, but many patients have difficulty quitting after their diagnosis. smoking cessation interventions for cancer patients thus far have had limited success. this is a pilot randomized controlled trial designed to determine if a new comprehensive, evidence-based smoking cessation intervention can improve quit rates for cancer patients who smoke.


Eligibility criteria:
inclusion criteria: * new diagnosis of head and neck or thoracic (including lung) cancer * undergoing radiation at johns hopkins radiation oncology for 5 or more weeks * english-speaking and able to provide informed consent * smoked any cigarettes in previous 14 days exclusion criteria: * palliative radiation * undergoing stereotactic radiosurgery * pregnant or breastfeeding

Keywords: smoking cessation head and neck neoplasms lung neoplasms thoracic neoplasms radiation
incidence of chronic pain after sternotomy

Conditions: Postoperative Pain; Postoperative Pain, Acute; Postoperative Pain, Chronic; Sternotomy

Summary: chronic postoperative pain is a well-known problem. chronic postoperative pain is defined as pain that begins following a surgical procedure and persists for more than 2 months without other obvious causes such as infection or underlying disease. sternotomy causes significant postoperative pain, and patients with chronic pain after sternotomy are often referred to pain clinics. the incidence of chronic pain after sternotomy ranges from 17% to 56%; in approximately one-third of these patients, chronic pain after sternotomy can compromise their quality of life by affecting their sleep patterns and impairing their ability to work. however, epidemiological studies on chronic pain after sternotomy are scarce. the aim of this study is to examine the incidence and possible risk factors of chronic pain following sternotomy operations. in this study, it was aimed to analyze the chronic pain findings of the patients who underwent sternotomy in the postoperative 3rd month.


Eligibility criteria:
inclusion criteria: * age between 18 and 80 years * american society of anesthesiologists' physical status i-ii-iii-iv * body mass index (bmi) between 18-35 kg/m2 * patients undergoing elective sternotomy exclusion criteria: * history of chronic analgesic therapy * patients with previous sternotomy surgery * patients who were operated under emergency conditions
high definition transcranial direct current stimulation (hd-tdcs) for refractory epilepsy

Conditions: Transcranial Direct Current Stimulation; EEG; Functional Magnetic Resonance Imaging; Refractory Epilepsy; Transcranial Magnetic Stimulation

Summary: to observe the clinical effect and safety of transcranial electrical stimulation on patients with refractory epilepsy before and after treatment and analyze its therapeutic mechanism.

all participants underwent a medical evaluation that included physical examination and routine laboratory studies before and after high definition transcranial direct current stimulation (hd-tdcs) treatment.upon meeting the inclusion criteria and providing informed consent, each participant will complete clinical assessments by a trained investigator and hd-tdcs treatment at anhui mental health centre. at least 90 participants were randomized (1:1:1) to receive "bilateral active" ,"unilateral active" or "sham" treatment protocol. the left electrical stimulation cathode was placed over cp5 with return electrodes placed at ft7, c1, p03 and p9 . the right electrical stimulation cathode was placed over cp6 with return electrodes placed at ft8, c2, po4 and p10 . in the bilateral treatment group, hd-tdcs treatment was placed on the left and right sides of the brain, at least eight hours apart. twenty 2-ma sessions (ramp-up and ramp-down periods of 30 and 30 seconds, respectively) were applied for 30 minutes,twice a day over 10 consecutive workdays. in the unilateral treatment group, hd-tdcs treatment based on epileptic discharge is placed on either the left or right side of the brain.ten 2-ma sessions were applied for 30 minutes,once a day over 10 consecutive workdays.sham hd-tdcs was delivered using the same protocol and current intensity, but the period of active stimulation was only during the ramp-up and ramp-down periods of 30 and 30 seconds. before and after the tdcs treatment, the patients had receiving a battery measure of neuropsychological tests, magnetic resonance imaging scan in multimodalities, veeg and resting motor threshold. the clinical symptom of participants were followed 4 weeks and 12 weeks after the last treatment.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of refractory epilepsy * right-handed and aged 18-50 years old and primary school education or above; * no major neurological or mental illness, no head injury, alcohol dependence or drug dependence; * during the experiment, the subjects did not smoke, drink, get sick and take psychotropic drugs, and there were no major life events that caused mood changes. exclusion criteria: * organic brain injury, neurological diseases or serious physical diseases; * have a history of substance abuse and drug dependence, or have used antipsychotic drugs in the past three months, and have serious suicidal tendencies; * there are contraindications for mri or eeg or transcranial magnetic stimulation.

Keywords: refractory epilepsy functional magnetic resonance imaging eeg transcranial magnetic stimulation
glaucoma telemedicine screening

Conditions: Glaucoma

Summary: the incidence of glaucoma is currently growing in the world's population, including the younger ones. however, the number of specialists who could perform examinations is unavailable in many areas of the czech republic outside large agglomerations. there is suitable alternative procedure that would make it possible to increase the intensity of screening, for example in general practitioners surgeries via application of teleophthalmology. early detection is absolutely essential for the patient (and therefore the health care system) for his/her further successful treatment. at the same time, all the necessary technical prerequisites are well known and commercially available.

detailed description: the aim of this study is to increase the detection of patients suspected of having glaucoma. for this purpose, the use of a combination of a mobile fundus camera and a mobile intraocular tonometer is proposed. these devices are used within the general practitioners' surgeries in the rural parts of olomouc and jeseniky region. their combination will allow a better stratification of patients suspected of glaucoma into the following groups: * patients with ocular hypertension (higher intraocular pressure and normal optic disc) * patients with normotensive glaucoma (normal intraocular pressure and suspected optic disc) * glaucoma patients (higher intraocular pressure and suspected optic disc) the advantage of involving a fundus camera is also in the possibility of the retinal pathologies detection such as diabetic retinopathy or age-related macular degeneration as a secondary outcome of the study. however, the primary goal of the study is to detect glaucoma and ocular hypertension. this area is also supported by the risk factors questionnaire and the patient education questionnaire. all patients will be evaluated by university hospital olomouc (fnol) ophthalmology specialists who will evaluate data coming through the specifically designed fnol telemedicine webportal from intraocular tonometers and fundus cameras. suspected patients will be invited to the fnol eye clinic for follow-up assessment using other modalities - perimeter, oct, stationary fundus camera, etc. the secondary goal of the project is to create a database combining retinal images with intraocular pressure values, and data from other modalities in suspected patients who come to the fnol for follow-up examinations. this goal will support the epidemiological study as well as it opens up the possibility of building a neural network over the database for easier classification of glaucoma patients in the future. as cognitive impairments (for instance alzheimer's disease) can also be inferred with the above-described equipment, patients are also presented with a questionnaire to examine their cognitive performance. data collected with use of questionnaires will be also part of the database. consequently, presenting the tertiary outcome of the described study.

Eligibility criteria:
inclusion criteria: * ≥ 18 years of age * informed written and verbal consent exclusion criteria: • absence of collaboration (informed consent)
efficacy of adding budesonide to poractant alfa to prevent bronchopulmonary dysplasia.

Conditions: Bronchopulmonary Dysplasia; Infant,Premature; Respiratory Distress Syndrome

Summary: this study evaluates the addition of budesonide to poractant alfa to prevent bronchopulmonary dysplasia in preterm infants with respiratory distress syndrome. half of the participants will receive budesonide and poractant alfa in combination, and the other half will receive poractant alfa with saline.

a randomized double bind controlled trial, designed to evaluate the addition of budesonide to poractant alfa to prevent bronchopulmonary dysplasia (bpd) in preterm infants with respiratory distress syndrome (rds). the usual treatment of rds includes ventilatory support and exogenous surfactant, however, a cronic lung disease known as bpd, is a complication found in many of these patients. bpd is a complex disease occurring in preterm infants recovering from rds and inflammation plays a key role in its physiopathology. animal derived surfactants have demonstrated to decrease the incidence of bpd, and porcine surfactant (poractant alfa) has and increased effect compared with bovine surfactant (beractant). budesonide is an inhaled anti-inflammatory steroid that has shown to reduce bpd when combined with beractant by decreasing lung inflammation, without secondary systemic effects, when combined with poractant alfa it could enhance even more this anti-inflammatory effect.

Eligibility criteria:
inclusion criteria: * birth weight \<1500g * gestational age ≥ 26 weeks * respiratory distress syndrome that requires exogenous surfactant at birth or in the first 12 hours of life. exclusion criteria: * major congenital anomalies. * perinatal asphyxia * respiratory depression secondary to general anesthesia.

Keywords: bronchopulmonary dysplasia respiratory distress syndrome budesonide poractant alfa
satisfaction in patients receiving the pegintron pen plus rebetol for hepatitis c (study p04244)(completed)

Conditions: Hepatitis C, Chronic; Hepacivirus

Summary: the current gold standard for treatment of chronic hepatitis c is pegylated interferon plus ribavirin. drug administration accuracy and ease of use will definitely determine treatment effectiveness. this is the idea behind the development and usage of the pegintron pen (pegpen). therefore, it is worthwhile to evaluate patients' satisfaction with this novel device. the results of the study will be used to improve pegpen training techniques for patients and health care providers.


Eligibility criteria:
inclusion criteria: * patients with chronic hepatitis c treated with the pegintron pen plus rebetol exclusion criteria: * not willing to participate in the study