effect of the early ultrasound-guided femoral nerve block performed by emergency physicians on pre-operative opioids usage in patients with proximal femoral fractures

Conditions: Femoral Fracture; Femoral Nerve Block

Summary: in france, approximately 80,000 patients with a fracture of the upper extremity of the femur (femoral neck or trochanter) are admitted in the emergency department. this is a serious disease with a one-year mortality rate of 29% (i.e., 1 of 5 women and 1 of 3 men), and significant consequences on quality of life and autonomy. the morbidity of these fractures is closely related to the occurrence of altered mental status or delirium, before and after surgery. the diagnosis is based on clinical features and x-rays of the hip. these fractures are associated with severe level of pain, before and after the surgery. for emergency physicians, managing appropriately the pain is a common problem at the admission in the emergency room. proper pain management is essential to ensure patients' comfort before surgery, but also to ensure their return to their previous functional and cognitive state after surgery. for patients, the goal of treatment is to regain walking as quickly as possible, while minimizing surgical and medical complications. however, severe pain induced by the fracture may lead to an acute altered mental status or delirium. in france, the latest guidelines about analgesia in emergency medicine reported that local anesthesia and loco-regional anesthesia (lra) are useful and should be promoted in emergency medicine. in 2010, these guidelines proposed to perform lra techniques such as iliofascial block more widely available. in 2016, the largest review of the literature on the use of regional nerve blocks for hip and femoral neck fractures in the emergency department \[medline (1946-2014), embase (1947-2014), cinahl (1960-2014), and the cochrane central register of controlled trials\] indicated that the femoral nerve block was likely to be at least as effective as, if not superior to, standard analgesic practices for decreasing pain after esf fracture. the authors of the meta-analysis suggested the superiority of ultrasound guidance compared to anatomic techniques or use of neurostimulation for an adequate needle placement. despite the increasing availability of ultrasound in the emergency department, recent literature supporting the efficacy of ultrasound-guided femoral nerve block, and the improvement of ultrasound skills in routine emergency medicine practice, the literature lacks of data about the effective duration of action, medication influence, and the occurrence of complications when an ultrasound-guided femoral nerve block is used by emergency physicians at the admission. for patients with hip fractures, it is questioned if ultrasound-guided femoral block used early on admission in the emergency room is in more efficient than intravenous morphine titration in reducing opioid use before surgery? our hypothesis is that early use of ultrasound-guided femoral nerve block in the emergency room decreases preoperative opioid use (intravenous and/or oral) in patients with proximal femoral fractures.


Eligibility criteria:
inclusion criteria: * patient whose age is ≥ 18 years * patient with a suspicion of proximal femoral fracture at the emergency triage, defined as direct traumatism on hip or fall associated with hip pain and/or clinostatism and/or lower extremity deformity with, typically, shortening of the externally rotated limb * patient with a verbal numerical pain rating ≥ 7 on emergency triage * patient with a diagnosis of esf fracture made on x-rays in the emergency department * patient with a normal lower extremity neurovascular examination * anticipated preoperative delay of at least 3 hours * patient affiliated to a health insurance plan * french-speaking patient * patient or relative who has given free, informed and written consent exclusion criteria: * patient with multiples trauma * no surgical treatment decided by the orthopedic team * prior femoral nerve block performed during pre-hospital time * patient was not walking before the fracture * patient has received opioids prior to ed admission (by home caregivers or as part of usual treatment) or buprenorphine or nalbuphine * contraindications to opioids: acute respiratory failure, acute liver failure, epilepsy not controlled by treatment, allergy; documented severe intolerance to morphine * contraindications to loco-regional anesthesia: constitutional or acquired coagulation disorder (anticoagulant treatment, acute hepatic failure), skin infection or wound near to the potential injection site, acute failure of an underlying disease, allergy to ropivacaine or chlorhexidine * patient already included in a type 1 interventional research protocol (riph1) * patient under guardianship or curatorship * patient deprived of liberty * patient under court protection * pregnant or breastfeeding patient