Kornimate/medical-research-clean huggingface dataset:
early determinants of multidimensional outcome at school age after neonatal arterial ischemic stroke

Conditions: Cerebral Infarction

Summary: while perinatal ischemic stroke is the most frequent form of childhood stroke, early determinants of outcome remain poorly understood. two main structural biases limit the accuracy of most studies: heterogeneity of the population and short follow-up. perinatal ischemic stroke includes several conditions that differ in pathophysiology and timing of occurrence. yet, it is not surprising that risk factors and outcome depend primarily on the type of stroke. age at evaluation also plays a major role after a neonatal insult. even though the original lesion is static and focal in perinatal stroke, its consequences grow over time within the maturing brain and affect all fields of neurodevelopment. the objective of the avcnn study was to delineate the determinants, clinical and imaging presentation, mechanism, and long term outcome of a category of perinatal stroke (neonatal arterial ischemic stroke: nais). this led to the avcnn cohort, which now gives us the opportunity to regularly monitor a large cohort of children having suffered an nais.

between november 2003 and october 2006, a cohort of one hundred symptomatic term newborns with ais confirmed through early brain imaging has been constituted. regular contacts with the families and their local physician have been maintained since enrollment. in 2010, families were asked through postal mail to participate in the 7 years assessment (avcnn7ans). those who accepted were contacted by phone by the coordinators of the study during the months preceding the child's seventh birthday and invited to attend a presentation in person of the current project. this evaluation took place face-to-face for a whole day in a medical setting close to the family residence. the evaluation team included a neuropsychologist, a speech therapist and either a pediatric neurologist or a pediatric physical and rehabilitation medicine practitioner.

Eligibility criteria:
inclusion criteria: * belonging to the avcnn cohort exclusion criteria: * lost to follow-up at 7 years. * refusal to participate in the current assessment.

Keywords: neonatal arterial ischemic stroke language development global intellectual functioning motor abilities
escitalopram treatment of night eating syndrome

Conditions: Night Eating Syndrome

Summary: night-eating syndrome (nes) is an eating disorder characterised by excessive eating at night, sleep disturbance and morning anorexia. this 12-week study examines the effect of escitalopram on symptoms of nes.


Eligibility criteria:
inclusion criteria: * age 18-70 years * presence of nes * bmi 25-50 exclusion criteria: * history of schizophrenia or other psychoses * history of bipolar disorder, anorexia nervosa, bulimia, binge eating disorder * current major depressive disorder * suicidal ideation * psychotropic drugs in the past month * drugs or herbal remedies that significantly affect body weight, current participation in a weight loss program, currently following a specialized diet (e.g., atkins, zone, etc) * lack of benefit with ssri treatment for nes * serious or unstable medical illness * allergy or hypersensitivity to escitalopram * pregnant, breast-feeding, or planning pregnancy in the next six months.

Keywords: eating disorder
base positioning wheelchair hemiplegic

Conditions: Wheelchair

Summary: the investigators looked at the population of hemiplegic stroke participants hospitalized with ghiv : the investigators assessed the postural control of the participants of the chair using mcpaa, and assessed the pain of the participants while sitting in a wheelchair. the investigators then had to the participants try positioning equipment and then prescribed it once the choice was made. the investigators then reassessed postural control and wheelchair pain with this positioning equipment.

for each hemiplegic participants with wheelchair user stroke, the investigators collect : date of birth, date of stroke, side of hemiplegia. the wheelchair propulsion mode, the degree of autonomy (fac and enjalber scales), the way bed - wheelchair transfers are made. assessment of wheelchair pain in the spine and ischia with eva. time to travel 10 meters in a wheelchair. postural control of the wheelchair is evaluated by the mcpaa. the investigators then carry out tests of positioning equipment : backrest, cushion, form elements and belt. this material is tried for several days. if it is appropriate (improvement on the postural control and on the pains), otherwise another material is tried. when the choice is made, the material is prescribed. the participant is seen again 3 months after the delivery of his personal material, and the same evaluation is redone.

Eligibility criteria:
inclusion criteria: * hemiplegia by stroke * wheelchair user exclusion criteria: * two-handed propulsion of the wheelchair * cognitive impairment preventing clinical examination

Keywords: wheelchair hemiplegia stroke postural control pain
urinary tubular biomarkers for chronic kidney disease

Conditions: Chronic Kidney Disease Stage 3

Summary: currently used tests for chronic kidney injury only assess the function of one part of the kidney: the filter called the glomerulus. the other part, called the tubule, is disregarded. based on many previous studies, the investigators have good reason to assume that a better prediction of the course of chronic kidney disease by testing tubular function will be possible. this is important, for example, when patients need to be treated with kidney-protecting drugs.

rationale chronic kidney disease (ckd) is a common and progressive condition that affects over 800 million people worldwide and is now one of the leading causes of mortality. the kidney consists of filters and tubules, but diagnosis of progressive ckd is currently based on filter function alone (estimated glomerular filtration rate (egfr) and albuminuria). however, it is tubular injury that drives ckd progression, and it is the tubule that is targeted by recently developed kidney-protective treatments. we hypothesize that a high-throughput tubular test panel, consisting of urine supersaturation and urinary extracellular vesicle (uev) biomarkers, improves the prediction of ckd progression thereby enabling the early initiation of kidney-protective treatment. objective(s) to develop a high-throughput tubular test panel, consisting of urine supersaturation and uev biomarkers, that improves the prediction of ckd progression. study type prospective diagnostic trial. study population adult patients with ckd stage g3 (egfr 30-59 ml/min/1.73 m2). methods urine samples are already collected as part of the standard of care and will be divided for measurement of albuminuria (standard of care) and urine supersaturation and uev biomarkers (this project). the performance of the tubular test panel will be analyzed by comparing it to that of the existing kidney failure risk equation. burden and risks the diagnostic tests will be performed on a urine sample that is already collected as part of routine clinical care. therefore, these diagnostic procedures do not pose an additional risk or burden. recruitment and consent participants will be recruited from the department of internal medicine outpatient clinics. for all study participants written informed consent will be obtained. the informed consent will include the approval (yes/no) to store samples for secondary use.

Eligibility criteria:
inclusion criteria: * chronic kidney disease stage 3 (egfr 30-59ml/min) exclusion criteria: * active glomerulonephritis treated with immunosuppression * kidney transplant recipient * current treatment with chemo- or immunotherapy for malignancy

Keywords: biomarker disease progression chronic kidney disease tubular function and injury urine risk assessment personalized medicine
continuous glucose monitoring in infants

Conditions: Neonatal Hypoglycemia

Summary: the purpose of this study is to employ continuous glucose monitoring to measure glucose profiles in newborn infants.

we will place a continuous glucose monitor on the infant within 2 hours of birth and record blood glucose values every 5 minutes via the monitor; in addition, the infant will receive blood glucose checks via heel stick according to the standard hospital glucose monitoring protocol.

Eligibility criteria:
inclusion criteria: * mother at least 18 years of age * infants born either appropriate for gestational age (aga) or large for gestational age (lga) * skin fold over superior gluteus area at least 1 inch in thickness as measured by skin calipers exclusion criteria: * infants born small for gestational age (sga) * infant birth weight \<2.5 kg * infant bmi \<10th percentile on olsen chart * infants born \<38 weeks gestation * infants with concern for intrauterine growth restriction (iugr) and short femur length based on ultrasound * mother is non-english speaking
fabry : national initiative of screening

Conditions: Ischemic Stroke Hospitalized

Summary: fabry disease is a genetic disease due to an enzymatic deficit. a screening of this disease allows patients to benefit from an enzyme replacement therapy and prevent the occurrence of life threatening manifestations such as an ischemic stroke. the purpose of the study is to determinate the prevalence of fabry disease in a population of male patients hospitalized for an ischemic stroke. this study, with a screening of fabry disease, allows the patients to make a precise diagnosis of their ischemic stroke and to facilitate the screening of the other members at the facility.


Eligibility criteria:
inclusion criteria: * hospitalized ischemic stroke * written and signed informed consent from patient or legal representative exclusion criteria: * patients belonging to a family which has a fabry disease's diagnosis confirmed

Keywords: fabry disease, screening, ischemic stroke
intravitreal triamcinolone acetonide for treatment of refractory diffuse diabetic macular edema

Conditions: Diabetic Retinopathy

Summary: phase i/ii study with intravitreal triamcinolone acetonide microspheres(retaac)for treatment of diffuse diabetic macular edema unresponsive to laser photocoagulation. study hypothesis is that single intravitreal injection of retaac is safe and efficient compared to conventional treatment. fifty patients will participate in this study and will be randomized into treatment and observation groups. efficacy will be evaluated by best corrected visual acuity and macular thickness measured by optic coherence tomography (oct) after 12 months of treatment.


Eligibility criteria:
inclusion criteria: * diabetes mellitus (type 1 or 2) * diabetic macular edema in study eye associated to diabetic retinopathy * diffuse macular edema defined as macular thickening determined by biomicroscopy and fluorescein angiography. * best corrected visual acuity between 34 (20/200) and 68 letters (20/50). * macular thickness greater than 300 mcm on oct. exclusion criteria: * uncontrolled systemic disease * start of medical therapy for diabetes or change in treatment from oral to insulin four months before initial visit. * hba1c levels greater than 10% * presence of retinal venous occlusion, cystoid macular edema,or other condition that would contribute to macular edema. * presence of epiretinal membrane * presence of vitreomacular traction in the study eye. * aphakic or anterior chamber intraocular lens in the study eye. * neovascularization of disc or elsewhere in the study eye. * history or presence of choroidal neovascularization in the study eye. * presence of rubeosis irides in the study eye. * eye opacity that interfere with clinical documentation and photography. * intra-ocular surgery 90 days before initial visit. * previous vitrectomy in study eye. * previous history of intravitreal or periocular corticoid or any other intravitreal drug in study eye. * scheduled surgery for study eye. * patients with known allergies to fluorescein, iodo-povidone or any component of study drug.
interhospital variability in programmes to prevent axillary lymphadenectomy sequels in breast cancer patients.

Conditions: Breast Cancer Lymphedema; Shoulder Injury

Summary: this study aims to determine the effectiveness of the different programmes of four spanish hospitals about prevention of axillary lymphadenectomy sequels in breast cancer patients.

this study aims to describe the different programs for the prevention of sequels of axillary lymphadenectomy in patients with breast cancer in four spanish hospitals, to determine the degree of compliance of these programs and to register the frecuency of lymphedema and limitation of mobility of the upper limb in breast cancer patients undergoing axillary lymphadenectomy between 2014 and 2016 in the four hospitals.

Eligibility criteria:
inclusion criteria: * suffering from axillary lymphadenectomy due to breast cancer treatment between 1 january 2014 until 31 december 2016. exclusion criteria: * lymphedema prior to surgery in any of the upper limbs or any malformation or injury that prevents comparison of both upper limb volumes. * cognitive impairment or intellectual disability that would prevent understanding the instructions of the study, as well as the purpose of the same. * serious condition.

Keywords: breast cancer breast cancer-related lymphedema shoulder injury prevention educational activity physiotherapy
tension band versus locking plate fixation for the treatment of patella fractures

Conditions: Patella Fracture; Surgery; Orthopedic Disorder

Summary: this study is a multicenter pragmatic, prospective, assessor-blinded, randomized independent clinical trial in which we compare locking plate fixation to standard tension band fixation in patients with patella fractures.

this study is a multicenter pragmatic, prospective, assessor-blinded, randomized independent clinical trial in which we compare locking plate fixation to standard tension band fixation in patients with patella fractures. primary objective the overall objective of the study is to compare the 1-year patient-reported knee injury and osteoarthritis outcome score (koos5) after standard tension band fixation with locking plat fixation for patients with patella fractures. secondary objectives several other analyses are of interest and are planned but are not objectives of this study. therefore, these analyses will, for the major part, hypothesis-generating. analyses of this type include, but are not limited to harms, muscle atrophy, pain, general health, gait function, time to return to work and economical consequences between the two groups.

Eligibility criteria:
inclusion criteria: * above 18 years of age * patella fracture suitable for surgically treatment, with both surgical methods * ao classification 34-b, 34-c exclusion criteria: * open patella fracture above gustillo grade 2 * bilateral patella fracture * total knee replacement in the affected extremity * other fractures of the affected extremity within the previous 12 months. * other reasons for exclusion (unable to understand danish, mentally unable to participate, etc). * prior ipsilateral patella fracture

Keywords: patella fracture surgery tension band plate
acceptance and commitment therapy with vestibular rehabilitation for chronic dizziness

Conditions: Chronic Dizziness

Summary: the purpose of this study is to examine the effectiveness of group acceptance and commitment therapy with vestibular rehabilitation for chronic dizziness, in comparison with self-treatment vestibular rehabilitation in addition to clinical management.

the purpose of this study is to examine whether group acceptance and commitment therapy combined with vestibular rehabilitation in addition to clinical management for patients with persistent postural-perceptual dizziness is more effective than treatment-as-usual(tau), which is self-treatment vestibular rehabilitation in addition to clinical management.

Eligibility criteria:
inclusion criteria: * persistent postural-perceptual dizziness (diagnosed by the diagnostic guideline of icd-11 beta version at dec. 2016) * existing handicap due to dizziness (dhi equal to or more than 16) * written consent exclusion criteria: * vertigo/dizziness/unsteadiness by organic brain diseases, diagnosed by neuro-otologist * vertigo/dizziness/unsteadiness explained by only organic cause or drug, diagnosed by neuro-otologist * physical status inappropriate for psychotherapy or vestibular rehabilitation * current psychiatric disorder other than anxiety disorders, somatic symptom disorder, or illness anxiety disorder (dsm-5), diagnosed by psychiatrist * history of schizophrenia or bipolar disorder diagnosed by psychiatrist * increased risk of suicide or self-harm diagnosed by psychiatrist * started or increased ssri/venlafaxine within 1 month before treatment * any cognitive behavioral therapy or vestibular rehabilitation except this study * otological surgery or device therapy for dizziness * insufficient understanding of the japanese language

Keywords: chronic dizziness persistent postural-perceptual dizziness acceptance and commitment therapy behavior therapy vestibular rehabilitation
a study of ibi362 in participants with metabolic dysfunction-associated steatohepatitis (mash)

Conditions: Metabolic Dysfunction-associated Steatohepatitis (MASH)

Summary: this is a multicenter, randomized, double-blind, placebo-controlled phase 2 clinical study evaluating the efficacy and safety of ibi362 in mash subjects. subjects will be randomly assigned to ibi362 low-dose, high-dose and placebo groups. the entire trial cycle includes a 8-week screening period, a 60-week double-blind treatment period, and a 4-week follow-up period.


Eligibility criteria:
inclusion criteria: * must be willing to participate in the study and provide written informed consent. * male or female, age 18 years or older at the time of signing informed consent * body mass index (bmi) ≥25 kg/m² * diagnosis of metabolic dysfunction-associated steatohepatitis (mash) (non-alcoholic fatty liver disease (nafld) activity score (nas) ≥ 4, with at least 1 point in steatosis, inflammation and ballooning each) and fibrosis stage f2 or f3 proven by a biopsy conducted during the screening period or by a historical biopsy conducted within the last 3 months prior to screening exclusion criteria: 1. subjects who the investigator thinks may be allergic to the components in the study drug or similar drugs 2. hba1c\>10% 3. history or current other forms of chronic liver disease other than mash 4. patients with positive hepatitis b surface antigen (hbsag). patients with positive hbcab will be eligible only when hbv dna test negative at screening 5. patients with hcv antibody positive. 6. patients with hiv antibody positive or syphilis specific antibodies positive (patients with non-specific antibody turned negative will be eligible) 7. model for end-stage liver disease(meld) \>12 or child-turcotte-pugh(ctp) \>6
fallopian tube removal as a method of ovarian cancer prevention: a descriptive study

Conditions: Ovarian Cancer

Summary: the purpose of this study is to better understand why women choose to have their fallopian tubes removed as a method for ovarian cancer prevention. this will be done through a paper questionnaire and phone interviews. the investigators hope to gain information that will allow us to better counsel women about ovarian cancer prevention.

women will be found eligible for this study after an eligibility questionnaire given over the phone. if one is found eligible, she will be sent a consent and paper survey to fill out and send back to the research coordinator. once that is completed, she will be given a phone interview in order answer additional questions of interest. lastly, the study participant will be contacted once a year over the phone to obtain follow-up information.

Eligibility criteria:
inclusion criteria: * female of at least 18 years of age * must speak english fluently * have had fallopian tubes removed as a method of ovarian cancer prevention exclusion criteria: * males * females under the age of 18

Keywords: fallopian tube removal salpingectomy ovarian cancer prevention
an open-label evaluation of degree of accommodation in pseudophakic patients bilaterally implanted with monofocal intraocular lenses

Conditions: Pseudophakia

Summary: this study will determine the ability of three different intraocular lenses to accommodate in patients who have previously undergone bilateral intraocular lens implantation.


Eligibility criteria:
inclusion criteria: * patients age 18 and older * patients must have undergone cataract surgery and have bilateral implants of the same model. the models eligible for inclusion include: * crystalens * crysalens hd * tecnis one monofocal * patients must have a healthy cornea and macula * patients must have 20/25 or better best corrected vision * able to provide written informed consent exclusion criteria: * bcva of less than 20/25 * on oral medications that could potentially block accommodation: * first generation antihistamines * anticholinergic agents * anti-psychotic medications * antidepressant medications

Keywords: patients who have previously undergone bilateral intraocular lens implantation
tactile acuity, right-left discrimination, and motor imagery in chronic rotator cuff-related shoulder pain

Conditions: Shoulder Pain; Rotator Cuff Syndrome

Summary: a common finding in various chronic musculoskeletal pain conditions is changes in the cortical sensorimotor region. functional brain changes associated with chronic pain include changes in the working body schema and associated mechanisms. however, the number of studies on this subject is quite limited, especially in the shoulder joint. there is no study on rotator cuff-related shoulder pain. in the light of this information, the present study aims to compare tactile acuity, right-left reasoning ability and motor imagery ability in chronic rotator cuff-related shoulder pain with healthy controls. in addition, the relationship of these markers with pain level, pressure pain threshold, range of motion, functionality, pain-related fear and central synthesis level will be investigated as a secondary objective.


Eligibility criteria:
inclusion criteria: * age 18-65 years * participants were classified with chronic chronic rotator cuff-related shoulder pain if duration was equal or greater than 6 months, as recommended by the international association for the study of pain for research purposes * pain at rest maximum 2 out of 10 on verbal numerical rating scale * pain over the deltoid and/or upper arm region for more than 4 weeks, pain associated with arm movement, and familiar pain reproduced with loading or resisted testing during abduction or external rotation of the arm * patient had to test positive at least 3 out of 5 symptoms-provoking tests: pain during neer test, hawkins-kennedy test, jobe test, painful arc between 60° and 120°, pain or weakness during external rotation resistance test exclusion criteria: * bilateral shoulder pain * corticosteroid injections less than 6 weeks prior to the enrolment * participants who were pregnant, mini mental state examination score \>24 * clinical signs of full-thickness rotator cuff tears (positive external and internal rotation lag tests or drop arm test) * evidence of adhesive capsulitis (50% or more than 30° loss of passive external rotation) * previous cervical, thoracic or shoulder surgery; recent fractures or dislocations on the painful shoulder * symptoms of cervical radiculopathy as primary complaint (tingling, radiating pain in the arm associated with neck complaints) * primary diagnosis of acromioclavicular pathology, shoulder instability * previous medical imaging confirming full-thickness rotator cuff tears or calcifications larger than 5mm * patients with competing pathologies (inflammatory arthritis, neurological disorders, fibromyalgia, malignancy) * history of cancer, neurologic, systemic, rheumatic or vascular disorder and use of psychiatric medication * participants performing overhead sport activities for more than 4hours/week