Kornimate/medical-research-clean huggingface dataset:
a trial comparing efficacy of hm3 versus f2 lithotripters for stone fragmentation

Conditions: Urolithiasis

Summary: the older lithotripter, hm3, has over 90% stone-free rate in most studies. however, it's less transportable than the new model, f2. there are no prospective trials performed to make a valid comparison between these 2 lithotripters in terms of efficacy of stone fragmentation and clinical outcomes.

shock wave kidney stone treatment was introduced in the 1980's. it is the least invasive method to treat kidney stone disease. the unmodified dornier hm3 has over 90% stone free rate in most studies. the mh3 requires immersion in a full bath, necessitating dedicated operative space. the new generation model f2 uses water cushion as a coupling medium and is easily transported. the generators used in both machines are also different. the newer model has the advantage of being more convenient due to portability and ease of use of the coupling medium, but there have been no prospective studies to compare these 2 machines in terms of efficacy of stone fragmentation and clinical outcomes. we seek to compare the hm3 with the f2 models in terms of stone free rates, complications and clinical outcomes to determine which machine is the most effective and will limit the need for additional stone procedures.

Eligibility criteria:
inclusion criteria: 1. patients diagnosed with urolithiasis and choose to have eswl treatment 2. age 18-90 years old 3. able to understand the informed consent exclusion criteria: 1. minors 2. cognitively impaired

Keywords: renal stones lithotripsy stone free rate
role of lymphocyte subsets and laboratory measurements in covid-19 disease

Conditions: COVID-19 Disease

Summary: to investigate the predictive role of lymphocyte subsets and other laboratory measurements in adult patients with covid-19.this was a single center, retrospective study that involved adult patients with confirmed diagnosis of covid-19. electronic medical records were reviewed. data including age, sex, symptom from onset to hospital admission and laboratory findings at admission of hospitalized patients with confirmed covid-19 were extracted and analyzed retrospectively.this study indicates that the levels of lymphocyte subsets (cd4+, and cd8+) are associated with disease progression and severity, along with prognosis in patients with covid-19.

this was a single center, retrospective study that involved adult patients with confirmed diagnosis of covid-19. electronic medical records were reviewed. data including age, sex, symptom from onset to hospital admission and laboratory findings at admission of hospitalized patients with confirmed covid-19 were extracted and analyzed retrospectively. identifying the possible immune factors and laboratory parameters is requisite for the early identification of patients with severe covid-19 and timely intervention for control of the disease. there is an unmet need to establish robust clinical cutoffs of lymphocyte subsets for predicting risk associated with icu admission, mechanical ventilation, and mortality in covid-19 patients. this retrospective study was thus carried out to improve knowledge and clinical utility of lymphocyte subset measurements, together with other laboratory measurements and clinical information, for understanding prognosis in covid-19 patients. these findings suggest that alterations in lymphocyte subsets and laboratory measurements play a significant role in the progression of covid-19.

Eligibility criteria:
inclusion criteria: * confirmed diagnosis of covid-19 disease. exclusion criteria: * the patients were excluded patients \<18 years age and without confirmed diagnosis of disease.
exercise prehabilitation for patients with nsclc before surgery

Conditions: Prehabilitation; Non Small Cell Lung Cancer; Cardiorespiratory Fitness; Surgery

Summary: to explore the safety and compliance of a wearable telemedicine device that can receive basic vital signs in real time, and its active supervision mode with real-time adjustment of exercise prescription for preoperative prehabilitation exercises in patients at home; and to evaluate the effectiveness of preoperative prehabilitation exercises in a telemedicine active supervision mode in patients undergoing thoracoscopic lung tumour resection, taking into account the patient's cardiopulmonary exercise test, postoperative complications and quality of life scores.


Eligibility criteria:
inclusion criteria: 1. capacity to give informed consent. 2. are able to tolerate surgery (i.e., segmentectomy, lobectomy) as indicated by standard clinical pre-op evaluation, including pulmonary function tests and cardiopulmonary exercise testing. 3. patients who can use a smartphone application. 4. patients who are diagnosed of stage i or ii non-small-cell lung carcinoma (nsclc) diagnosis, with or without pre-operative histologic confirmation. 5. patients who can perform an exercise program for at least 4 weeks from the first visit to the preoperative clinic to elective surgery. exclusion criteria: 1. known contraindication for cardiopulmonary exercise testing. 2. patients who have a major medical or psychiatric disorder that is expected to affect exercise. 3. pregnancy or lactating women.

Keywords: prehabilitation cardiorespiratory fitness non-small cell lung cancer exercise wearable technology surgery
efficacy of a minimal intervention educational program in the asthma control and exacerbations prevention

Conditions: Asthma

Summary: the asthma clinical practice guidelines categorize with the highest evidence level the effectiveness of educational programs. however, health care professionals not regularly applied it. this may contribute to inadequate control of the disease. consequently, their designs and implementation strategies should be reviewed. hypothesis. an asthma educational program based on a limited intervention, managed by professionals with minimal training in education, could provide a significant decrease in the morbidity of the disease. objective. determine the effectiveness, in terms of prevention of exacerbations (future risk) and improved asthma control (current control) of an educational program based on a reduced or minimal intervention.

method. a prospective, multicentre, centre randomized ("clusters analysis"), controlled, designed to evaluate the efficacy (reduction of exacerbations) and control degree control (increased act score) of an asthma educational program based on a limited intervention in patients with mild to moderate persistent asthma with an act \ 15 days), compliance level, spirometric values and daily dose of inhaled corticosteroid (microg. or equivalent per day). patients in the intervention group will receive the limited educational asthma program, which have three parts: basic information, establishment and revision of a small action plan (miniplan) and training and review of the inhalation skill of the prescribed device. educators involved will attend a short workshop (6 h), where they will be trained in the program.

Eligibility criteria:
inclusion criteria: * male and female asthma patients with mild or moderate persistent asthma after treatment according to criteria of the gina2009. * aged 18 and under 70 years. * with act (asthma control test) \<20 treated at the outpatient clinics of the participating centers. exclusion criteria: * severe exacerbation of asthma (which required emergency room visit and/or hospitalization) within 30 days prior to visit 1. * severe disabling comorbidity.

Keywords: educational asthma program clusters analysis study asthma control test
evaluation of qol, tolerability and use of zoladex 10,8 safesystem for advanced pca - german ipep trial

Conditions: Prostate Carcinoma

Summary: purpose of this study is the evaluation of qol, tolerability and use of zoladex 10,8 safesystem for advanced pca under naturalistic conditions


Eligibility criteria:
inclusion criteria: * patients with pca, who will be treated with zoladex 10,8 safesystem based on the current spc

Keywords: prostate carcinoma lhrh zoladex
beta-glucan on fecal microflora in polypectomized patients

Conditions: Polypectomized Patients

Summary: the aim of this study is to determine the effect of the potential prebiotic beta-glucan on the intestinal microflora, the bacterial enzyme activity (beta-glucuronidase and beta-glucosidase) in the feces, the fecal ph and the concentration of fecal short-chain fatty acid in polypectomized patients. also the in vitro anti-cyto- and anti-genotoxicity of fecal water will be examined on human cell culture (ht29). during the trial, patient's clinical symptoms (intestinal habits), physical activity, well-being and food intake will be recorded.

prebiotics, such as short- and long-chain fructo-oligosaccharides are fermented by the microflora colonizing the gastrointestinal tract, and they selectively stimulate the growth or the activity of one or limited number of bacteria within the intestine. beta-glucans are polysaccharides occurring in the bran of cereal grains, the cell wall of saccharomyces cerevisiae and bacteria, certain types of fungi, seaweed and many kinds of mushrooms. the aim of this study is to determine the effect of the potential prebiotic beta-glucan on the intestinal microflora, the bacterial enzyme activity (beta-glucuronidase and beta-glucosidase) in the faeces, the faecal ph, and the concentration of faecal short-chain fatty acid in polypectomized patients.

Eligibility criteria:
inclusion criteria: * the subjects must have biopsy and histologically confirmed adenomatous polyps ≥ 1cm in size or ≥ 3 in number with moderate or severe dysplasia exclusion criteria: * subjects ≥ 75 years of age * subjects who are pregnant or desire to become pregnant during the study period * subjects who are considered to be poor clinic attendees * subjects who have been on antibiotics within the previous month or are likely to require antibiotics during the trial * subjects who consume prebiotics or probiotics within the previous month or are likely to require antibiotics during the trial * subjects with colon cancer * subjects with additional gastrointestinal disorders (e.g., crohn's disease or ulcerative colitis) * subjects with malignancy or any end-stage organ disease

Keywords: beta-glucan faecal microflora polypectomized precancerous nonmalignant condition
long term prevention of nausea and vomiting in gynecologic laparoscopy

Conditions: Uterine Myoma, Ovary Neoplasm, Adenomyosis

Summary: to compare postoperative nausea and vomiting (ponv) and perioperative outcomes of gynecologic patients undergoing laparoscopic surgery after scheduled administration of intravenous ramosetron during hospital stays. * randomized controlled arm : placebo versus ramosetron injection * administration schedule : immediate postoperative status, 12 hrs after surgery, 36hrs after surgery

surgical outcomes including operative time, blood loss, hb change, postoperative pain, nausea/vomiting scale, times of rescue therapy, and complications

Eligibility criteria:
inclusion criteria: * age: 18\< or =, = or \<70 with benign gynecologic disease * asa-class i-ii * no-definite malignancy by us, ct/mri, ca 125 \< 500iu/ml * non-smoker exclusion criteria: * conversion to laparotomy * hx of malignancy * smoker * suspicious malignancy

Keywords: ramosetron, postoperative nausea and vomiting, laparoscopy
evaluation of the evolution of pregnancies in the first trimester following mar management during a covd-19 pandemic period

Conditions: Covid-19

Summary: because of the physiological changes inherent in pregnancy, pregnant women with lower respiratory tract infections often have more worrisome outcomes compared to non-pregnant individuals, including a higher rate of hospital and intensive care unit admissions.


Eligibility criteria:
inclusion criteria: * patient included in a medically assisted procreation (mar) protocol aged between 18 and 43 years of age * patient who has already signed a consent to management exclusion criteria: * patient who expressed opposition to participating in the study

Keywords: covid-19 sars-cov-2 ards icu pregnant women pregnancy fetus middle east respiratory syndrome mers maternal respiratory impairment medical assisted procreation mar frozen embryos
delayed primary closure using negative pressure wound therapy

Conditions: Infection Abdominal

Summary: surgical site infection rates for contaminated or dirty laparotomy wounds can be as high as 45%. surgical management of dirty and contaminated wounds has been controversial in the literature and between surgeons. primary closure (pc) of these wounds can lead to multiple complications including surgical site infection (ssi), necrotizing soft tissue infection, wound and fascial dehiscence, evisceration, sepsis and hernia development. however, an alternative technique of utilizing secondary intention results in prolonged healing time and increased cost and healthcare resource utilization. delayed primary closure (dpc) was developed to address many of these issues. bhangu completed a systematic review and meta-analysis comparing primary versus delayed primary skin closure in contaminated and dirty abdominal wounds. they included 8 studies randomizing 623 patients with contaminated or dirty abdominal wounds to either dpc or pc. the most common diagnosis was appendicitis (77.4%), followed by perforated abdominal viscus (11.5%), ileostomy closure (6.5%), trauma (2.7%), and intra-abdominal abscess/other peritonitis (1.9%). the time to first assessment for dpc was between 2 and 5 days postoperatively. in all studies, the dpc group had significantly less ssis using a fixed-effect model (odds ratio, 0.65; 95%ci, 0.40-0.93; p = .02). however, heterogeneity was high (72%), and using a random-effects model, the effect was no longer significant (odds ratio, 0.65; 95% ci, 0.25-1.64; p = .36). additionally, all of the studies were found to be at high risk of bias, with marked deficiencies in study design and outcome assessment. a recent systematic review showed improved fascial closure rates with negative pressure wound therapy (npwt) yet, a large national study using npwt to perform a dpc has been shown to actually decrease the rate of closure. access to npwt has increased over the years and innovative wound management techniques including incisional application of negative pressure therapy have allowed clinicians to apply this method to dirty wounds following the principles of delayed primary closure. there are currently no studies available to help determine the safety and efficacy of advanced npwt techniques to optimize surgical wound management from the open abdomen to skin closure. within our division, we have decided to make a practice change and develop a standard closure plan for open abdomens using the negative pressure devices available within our institution.


Eligibility criteria:
inclusion criteria: * 18 years or older * undergone midline laparotomy and managed with an open abdomen for at least one day * contaminated or dirty wound classification exclusion criteria: * less than 18 years of age * prisoners * pregnant females * non-surgical patients
study of the efficacy of daylight activated photodynamic therapy in the treatment of cutaneous leishmaniasis

Conditions: Cutaneous Leishmaniasis

Summary: the aim of the project is to determine whether daylight activated photodynamic therapy is effective in treating cutaneous leishmaniasis caused by l. major and l. tropical. pdt is classically performed as a two-step procedure in which mal application to the lesion constitutes the first step, and ppix activation by light of appropriate wavelength from an artificial light source constitutes the second step. based on the knowledge that red and blue light required to activate ppix are part of the daylight spectrum, the investigators postulated that effective ppix activation can be obtained by exposure of the mal treated lesions to daylight thus substantially simplifying the pdt procedure by omitting the 3 hour incubation period and the subsequent exposure to artificial light. in accord, in a recent study the investigators showed that daylight-activated pdt (da-pdt) was as effective as conventional mal-pdt in treating precancerous actinic keratoses lesion. furthermore the investigators found that da-pdt is significantly less painful than conventional mal-pdt. the investigators now propose to study the efficacy of da-pdt in the treatment of cutaneous leishmaniasis. da-pdt has obvious advantages to conventional leishmania treatment forms: as opposed to most of the available treatment options, da-pdt is a self-administered procedure that does not require the assistance of medical personnel. secondly, judged by our experience with mal-pdt, only few treatment sessions are required for effective parasite killing as opposed to the prolonged procedures usually required for treatment of leishmaniasis. third, pdt has the far the best safety profile of all available treatment options.


Eligibility criteria:
inclusion criteria: * at least 2 skin lesions with leishmania caused by l. major or l. tropica exclusion criteria: * pregnant or lactating women

Keywords: cutaneous leishmaniasis photodynamic therapy
bucy vs. tbicy for allo-hsct in t-all patients

Conditions: T-Cell Lymphocytic Leukemia; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; Total Body Irradiation; Chemotherapy

Summary: t-cell acute lymphoblastic leukemia (t-all), a hematological malignant neoplasm of immature t cells, accounting for a morbidity of 10-15% among pediatric and 20-25% among adult patients of all. despite the application of improved intensive therapies, the overall survival (os) of t-all patients is still unsatisfactory, with a 5-year os rate of less than 60% in adults and 85% in children. over the past few decades, allogeneic hematopoietic stem-cell transplantation (allo-hsct) has emerged as a potential and the most likely curative treatment for patients with high-risk hematological malignant neoplasms, and it has been proven that allo-hsct could hold the potential to improve the prognosis of t-all patients and may even cure t-all. the two most common myeloablative conditioning regimens for t-all patients with allo-hsct were total body irradiation (tbi) plus cyclophosphamide (tbi-cy) and busulfan (bu) plus cyclophosphamide (bucy). the most common use conditioning regimen for all patients is the tbi-cy conditioning regimen over other hematological malignancy patients because tbi possess potent and distinct anti-leukemic effects, particularly in organs not easily affected by systemic chemotherapy and intense immunosuppressive effects. however, tbi-based conditioning regimens may cause a high risk of cataracts, interstitial pneumonitis (ip), engraftment failure and even subsequent malignant neoplasms (smns). to avoid these disadvantages, intravenous bu replaced tbi as a part of conditioning. extensive studies have shown that allo-hsct with conditioning regimens based on tbi could benefit survival compared with conditioning regimens based on chemotheraphy in treating all. we retrospectively analyzed post-10-year data from t-all patients from two transplant centers, and all the databases were used to eliminate confounding factors via psm. we demonstrated that the tbi-cy conditioning regimen had inferior efficacy to the bucy conditioning regimen, especially for t-all patients who were children, refractory, had extramedullary disease before transplantation, had active disease or an mrd-positive status at allo-hsct, or who received haplo-hsct.


Eligibility criteria:
inclusion criteria: 1. t-all patients aged \> 2 years and ≤55 years; 2. for the first time accept allo-hsct; 3. with eastern cooperative oncology group (ecog) performance status of 0-3; 4. signing an informed consent form, having the ability to comply with study and follow-up procedures. exclusion criteria: 1. with other malignancies; 2. with a previous history of autologous hematopoietic cell transplantation, allogeneic hematopoietic cell transplantation or chimeric antigen receptor t cell therapy; 3. with uncontrolled infection intolerant to haploidentical hematopoietic cell transplantation; 4. with severe organ dysfunction; 5. in pregnancy or lactation period; 6. with any conditions not suitable for the trial (investigators' decision).
total body perfusion in patients with chest pain

Conditions: Coronary Artery Disease

Summary: the purpose of this study is to better understand changes in obstructive coronary artery disease in different organs other than the heart such as the brain and the kidneys using a new generation total body pet scanner.

patients with chest pain and suspected cad will be studied using total body pet imaging with o15-water perfusion imaging

Eligibility criteria:
inclusion criteria: * documented history of chest pain with ct imaging showing a potential for obstructive coronary artery disease * ability to sustain adenosine injection 0.14 mg/kg/min exclusion criteria: * second or third degree av-block without pacemaker * sick sinus syndrome * consumption of coffee or aminophylline within 12 hours of administration * recent use of dipyridmole or dipyridamole-containing medications * known hypersensitivity to adenosine * unstable acute mi or acute coronary artery syndrome, and prior cardiac transplantation * active wheezing and bronchospasm * sinus bradycardia with hr\<40 bmp
impact of severe intraoperative hyperglycemia on infection rate after elective intracranial interventions

Conditions: Hyperglycemia; Craniotomy; Infection Post Op

Summary: severe intraoperative hyperglycemia (sih) is recognized as one of the important risk factors for the increasing of the postoperative infections rate, which can negatively affect the final outcome of surgical treatment. studies in recent years have shown a much higher incidence of wound infections, respiratory and urinary tract infections in patients who intraoperatively had an increase in blood glucose level (bgl) above 180 mg/dl (10 mmol/l). this problem in neurosurgery is especially important due to the high proportion of patients with acute injuries and potentially long-term need for postoperative intensive care, as well as the frequent use of drugs that increase blood glucose level (steroids) in neurooncology. most published studies include patients from both of these groups. this study is aimed to assess the impact of severe intraoperative hyperglycemia on the incidence of infectious complications only in patients scheduled for elective intracranial interventions.


Eligibility criteria:
inclusion criteria: adult patients (\>18 years) scheduled for elective intracranial (open or endoscopic) intervention. exclusion criteria: diagnosis of infection (local or systemic) in preoperative period; urgent intervention.