Kornimate/medical-research-clean huggingface dataset:
treatment of mucosal bolivian leishmaniasis

Conditions: Mucosal Leishmaniasis

Summary: the purpose of this protocol is to conduct a randomized comparison of the efficacy and tolerance of miltefosine, lamb, and pentavalent antimony for the treatment of mucosal leishmaniasis. with such controlled pharmacodynamic data, and additional considerations of administrative convenience (oral \>\>iv) and cost, we hope that it will be possible for policy makers, treatment professionals, and patients to choose the most appropriate therapy for ml.


Eligibility criteria:
inclusion criteria: * weight over 45 kg * parasitological confirmation of the lesion will be made by visualization of leishmania, culture of leishmania, or molecular identification of leishmania (pcr) from the biopsy or aspirate of the lesion. exclusion criteria: * previous treatment for leishmaniasis in the last 12 months * concomitant diseases by history that would be likely in the pi's opinion to interact, either positively or negatively, with treatment * values of complete blood count, liver function (aspartate aminotransferase, alkaline phosphatase), renal function (creatinine), pancreatic function (lipase), or uric acid beyond 1.5 x normal range * ekg with clinically significant abnormalities * women of childbearing age not agreeing with the use of secure reproductive contraception for 4 months after initiating miltefosine therapy.
diagnosis of gastritis, h. pylori infection and atrophic gastritis in dyspeptic patients

Conditions: Gastritis, Atrophic; Helicobacter Pylori Infection; Intestinal Metaplasia; Gastritis

Summary: gastric cancer is the third most common cause of cancer-related death worldwide (1). upper endoscopy is necessary to detect neoplastic macroscopic features at an early stage, but subtle abnormalities in the gastric mucosa are often missed or misdiagnosed (1). helicobacter pylori (hp) is involved in the pathogenesis of gastric diseases, such as, peptic ulcers, gastric lymphoma, and gastric cancer. therefore, the necessity to recognize malignant gastric lesions at an early stage is imperative.

previous i-scan™ technology uses white light as illumination light and digital post-processing of the reflection afterwards creates images yielding the virtual chromoendoscopic image. emission of white light alone causes a potential limitation for the current i-scan™ technology to obtain high-quality images of microvascular patterns on the mucosal surface compared to narrow band imaging (nbi) with optical magnification. pentax medical (hoya, tokyo, japan) developed the optical enhancement™ (oe) system, which combines bandwidth-limited light with an endoscopy video system. the oe system combines digital signal processing with optical filters that limit the spectral characteristics of the illuminating light, connecting the peaks of the hemoglobin absorption spectrum (415 nm, 540 nm, and 570 nm) to create a continuous wavelength spectrum. this system has two modes that use different filters to optimize the visualization of specific features. mode 1 is designed to improve visualization of microvessels with enough light. mode 2 is designed to improve contrast of white-light observation by bringing the color tone of the overall image closer to that of natural color (white color tone) with more light than mode 1 filter. in addition, high definition optical magnification endoscopes have been developed and can combine high-definition imaging with optical magnification to produce detailed images with magnification of up to 136×. this imaging technique facilitates the evaluation of the superficial vascular aspects of the mucosa, enabling the identification of early signs of inflammation or lesions not previously seen with conventional endoscopy.

Eligibility criteria:
inclusion criteria: * above 18 years of age * agreed to participate in the study * patients with dyspepsia in accordance with rome criteria exclusion criteria: * those taking nsaids, ppis or antibiotics three weeks prior invitation * severe uncontrolled coagulopathy * prior history of gastric surgery * those pregnant or nursing females

Keywords: endoscopy gastritis
multiple dose study in cancer patients: safety and tolerability of bms-754807 in advanced or metastatic solid tumors

Conditions: Neoplasms; Solid Tumors; Metastases

Summary: this is a phase 1 dose escalation study to determine the safety, tolerability, pharmacokinetics, pharmacodynamics and preliminary anti-tumor activity of bms-754807 in patients with advanced or metastatic solid tumors. in addition, the study is expected to identify the recommended dose or dose range of bms-754807 for phase 2 studies


Eligibility criteria:
inclusion criteria: * subjects with advanced or metastatic solid tumors for whom the standard of care is ineffective or inappropriate * ecog performance status 0-1 * at least 4 weeks between surgery or last dose prior anti-cancer therapy exclusion criteria: * symptomatic brain metastases * any disorder or dysregulation of glucose homeostasis {e.g. diabetes) * uncontrolled or significant cardiovascular disease * inadequate bone marrow, liver or kidney function

Keywords: advanced or metastatic solid tumors or neoplasms
evaluation of an early childhood development intervention for hiv-exposed children in cameroon

Conditions: Early Childhood Development in HIV-Exposed Children

Summary: there is substantial evidence that early childhood development (ecd) programming can improve child health and development outcomes. an important component of ecd programming is supporting positive parenting and early stimulation practices. while many parents could benefit from such programming, mothers that are hiv-infected may particularly benefit given the higher risks of poorer child development among hiv-exposed children. catholic relief services (crs) in cameroon is implementing the key interventions to develop systems and services (kidss) ecd program for hiv-exposed children. this impact evaluation will ascertain to what extent the kidss home-based component of the ecd model affects attainment of age-appropriate developmental milestones (measured by the ages and stages questionnaire 3 (asq-3)) in hiv-exposed children in cameroon. the study design is a cluster-randomized controlled trial with a cohort of 200 mother/child dyads across 10 study clinics. hiv+ mothers will be recruited during pregnancy and their children will be followed up until 18 months of age. the intervention group will receive regular home-based ecd services focused on positive parenting and early stimulation. the control group will not have any exposure to ecd services, though they may receive home-based services focused on hiv care and treatment, hygiene, and nutrition. randomization occurs at the clinic (cluster) level.


Eligibility criteria:
inclusion criteria: * hiv-positive * pregnant and currently in 3rd trimester * must reside in nkoldongo district or djoungolo district * willing to be followed up for up to 21 months (pregnancy + postpartum periods) * agrees to voluntary participation

Keywords: hiv-exposed early childhood development cameroon
examining the effects of activity management in women with fibromyalgia syndrome

Conditions: Fibromyalgia

Summary: purpose: to determine the effects of activity management training on pain, occupational performance, quality of life, depression, anxiety and occupational balance in women with fibromyalgia syndrome (fms). in addition to, reducing pain, which is the main symptom of fms, by regulating the activity-rest cycle, it is aimed to increase people's participation in daily life and improve their quality of life. method: a randomized controlled trial. a total of 10 sessions of individual-internet-based activity management training are applied to women with fms in the intervention group, 2 sessions a week for 5 weeks, 1st and 10th sessions are pre- and post-training evaluation. assessments before and after training the revised fibromyalgia impact questionnaire (fiqr), canadian occupational performance measure(copm), pain-activity patterns scale (pomp/apps) ,nottingham health profile,the hospital anxiety and depression scale,the occupational balance questionnaire (obq) is applied.although no intervention is applied to the control group, only preliminary and final evaluations are completed.


Eligibility criteria:
inclusion criteria: * having been diagnosed with fms by a specialist physician, * being a woman between the ages of 18-64, * to be literate, * having and actively using a smartphone or a computer exclusion criteria: * any disease accompanying fms, the presence of psychiatric illness and endocrine disorders, * have previous activity management training, * currently and up to 4 weeks on psychotropic medication, * breastfeeding and pregnancy

Keywords: fibromyalgia activity management pain management occupational balance occupational performance occupational therapy
"covid-19 and diabetes outcomes"

Conditions: Coronavirus; Diabetes

Summary: covid-19 (coronavirus disease-2019) is a life-threatening infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (sars-cov-2) that appeared in december 2019 in the wuhan district. covid-19 has since affected more than 150 countries across the world and especially france. the first epidemiological data, mostly from chinese studies, indicate that diabetes is one of the most common comorbidities, with high blood pressure, in patients with covid-19. moreover, the presence of diabetes at admission would be a risk factor for both icu hospitalization and death. nevertheless, specific data on people with diabetes and covid-19 are fragmentary, justifying the achievement of a dedicated prospective observational study. the french nationwide coronado study aims to specifically describe the phenotypic characteristics of patients with diabetes admitted to hospital with covid-19 infection. particular attention will be devoted to glycemic control at admission (i.e. the level of hba1c), the diabetic complications, as well as anti-diabetic and antihypertensive therapies. this study will provide answers to caregivers and patients with diabetes regarding the risk factors related to diabetes for covid-19 prognosis. this pilot study will be used for the development of new studies and for the establishment of recommendations for the cost of care in patients with diabetes and covid-19.


Eligibility criteria:
inclusion criteria * patients admitted in a hospital center since 10th march 2020 * patients with covid19 with biological proof (specific pcr) or with clinical and radiological diagnosis. * patient with diabetes known before the admission * new onset diabetes discovered at admission (hba1c value strictly greater than 6.5%) exclusion criteria * subjects opposed to the use of their data * minors, adults under guardianship, protected persons * subject having already been included in the coronado study (subject readmitted after discharge following the initial stay). only the data of the first stay will be maintained.
pelvic girdle pain in a pregnant population in western norway.

Conditions: Pelvic Girdle Pain

Summary: the objectives in this study are 1. to explore the incidence and cumulative prevalence of pelvic girdle pain (pgp) and its subgroups in a prospective longitudinal study during pregnancy, from 18 weeks until 6 weeks after delivery. 2. to examine the outcome of chiropractic management for a dominating one-sided pgp subgroup of pregnant women in a single-blinded controlled study, and to use efficacy measures that include pain, functional impairment, and sick-leave frequency. 3. to investigate possible predictors for treatment outcome in one-sided pgp in pregnant women.


Eligibility criteria:
inclusion criteria: * lumbopelvic pain * pelvic pain * performed ultrasound examination at 18th pregnancy week * expected normal pregnancy without complications * good competency in norwegian language

Keywords: pelvic girdle pain chiropractic single-blinded outcome study
to evaluate 1 year extension study of the efficacy and safety of tocilizumab in patients with moderate to severe rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: the purpose of this study is to evaluate 1 year extension study of the efficacy and the safety during treatment tocilizumab in patients completing treatment cwp-tcz301 study with moderate to severe active ra and an inadequate response to current dmard.


Eligibility criteria:
inclusion criteria: * patients who have been satisfied the in/exclusion criteria of cwp-tcz301 * patients who have been withdrawn after receiving escape therapy or completed treatment during 24weeks in cwp-tcz301 study * patients who able to enroll in this study within 12 weeks after last infusion of cwp-tcz301 * willing to give written informed consent exclusion criteria: * history of severe allergic or anaphylactic reactions to investigational product in cwp-tcz301 study * alt or ast \> ulnⅹ2.5 * platelet count \< 100ⅹ103/ μl * wbc \< 3,000/mm3 * absolute neutrophil count \< 1,000/mm3 * absolute lymphocyte count \< 500/mm3 * total bilirubin \> ulnⅹ2
will preoperative mri breast in women under 56 years with breast cancer change primary treatment

Conditions: Breast Neoplasm

Summary: the study is a prospective randomised multicenter trial assessing the additional value of breast mri in women under 56 years of age with newly diagnosed breast cancer. will preoperative breast mri change treatment regimen? will preoperative breast mri reduce the number of primary surgeries? will preoperative breast mri increase the rate of mastectomies? will preoperative breast mri be cost effective?

completed: the study has concluded normally; participants are no longer being examined or treated (i.e., last patient's last visit has occurred)

Eligibility criteria:
inclusion criteria: * women under 56 years of age * newly diagnosed breast cancer * swedish or english speaking exclusion criteria: * claustrophobia * pregnancy * renal failure * metal items in patients
endoscopic pilonidal sinus treatment (epsit) versus sinus laser closure (silac) versus lay open technique

Conditions: Pilonidal Sinus

Summary: aim of the work to compare sinus laser closure versus lay open technique versus endoscopic pilonidal sinus treatment as regards recurrence rate, operative data, postoperative pain, intra and postoperative complications, healing time and return to daily activity.


Eligibility criteria:
inclusion criteria: * patients with symptoms from sacrococcygeal pilonidal sinus . exclusion criteria: * abscess formation * immunodeficiency. * patients with congenital asymptomatic pits. * patient with psychiatric disease disabling surgical intervention. . pregnant females.
3d high resolution manometry and balloon expulsion test in diagnosis of dyssynergic defecation in children

Conditions: Children; Constipation

Summary: anorectal 3d manometry (3d hram) is the most advanced version of manometric equipment that measures pressures along the anal canal in a very detailed manner. it provides complete data about pressure profile of anorectum and may indicate impaired defecation dynamics. balloon expulsion test (bet) is a cheap, easy way to diagnose constipation as the result of outlet obstruction. our aim is to compare this two methods of diagnosis of dyssynergic defecation and to find the correlation between this diagnostic equipment.

patients with the diagnosis of constipation will be enrolled in the study. each patient will be investigated by anorectal manometry and after the procedure bet will be performed at the same day. during anorectal manometry conventional manometric parameters will be recorded, such as resting pressure, squeeze pressure, bear down manoeuver, thresholds of sensation and threshold of recto anal inhibitory reflex. 3d picture of anal canal will be recorded. after the manometry standard bet will be performed. the balloon will be inserted into the rectum and patient will be asked to expel it in private during 1 min. data from manometry will be correlated with the success rate of bet.

Eligibility criteria:
inclusion criteria: * constipation * parental agreement exclusion criteria: * after surgery on lower gastrointestinal tract * diagnosis of inflammatory bowel disease * diagnosis of other disorder that may affect anorectum function * parental disagreement

Keywords: anorectal manometry children constipation
secular trends in the prevalence of diabetes in india

Conditions: Type2 Diabetes; PreDiabetes

Summary: series of epidemiological studies have been carried out by the research team since 1988 studying the changes in the prevalence of type 2 diabetes, prediabetes and associated risk factors. these studies have shown that the determinants to rising prevalence of diabetes vary among populations and with time. comparative studies from the same region can help to understand the secular changes occurring in a specific population. in this proposal we intend to conduct a cross-sectional survey with varied levels of urbanisation and compare the findings with our earlier reported data to assess the degree of changes in dysglycaemic prevalences. the primary aim of the proposal is to study the secular changes and the prevalence of diabetes, prediabetes and associated cardio-metabolic risk factors with varying levels of urbanization. a multi-stage random selection method will be used. field workers will conduct an enumeration of the individuals above 20 years of age. in each location, streets will be randomly selected to have an equal representativeness from different socio-economic strata. all eligible family members of the selected households are invited for the survey. the study outcomes will be of relevance in public health research in modeling effective national healthcare policies.


Eligibility criteria:
inclusion criteria: willing to participate and provide informed consent form. exclusion criteria: age less than 20 years,cognitive impairment, unwilling to participate
examining the effect of acute intermittent hypoxia on serum blood proteins and lower limb function

Conditions: INCOMPLETE SPINAL CORD INJURY (ASIA D); Able Bodied

Summary: the goal of this study is to clarify mechanisms of acute intermittent hypoxia and to examine the effect on lower limb function in persons with chronic, incomplete spinal cord injury.

the goal of this study is to clarify mechanisms of acute intermittent hypoxia by examining changes in blood biomarkers, neural excitability, and hemoglobin mass. we also aim to clarify how these changes relate to changes in lower limb function in persons with chronic, incomplete spinal cord injury by measuring force steadiness and voluntary muscle activation.

Eligibility criteria:
inclusion criteria: * 18 to 75 years old (the latter to reduce likelihood of heart disease) * medically stable with medical clearance from physician to participate * motor-incomplete spinal cord injuries at or below c2 and at or above l5 * ais a-d at initial screen, or other non-traumatic spinal cord injury disorders (e.g. multiple sclerosis, als, tumors, acute transverse myelitis, etc.) * more than 1 year since isci to minimize confounds of spontaneous neurological recovery * ability to advance one step overground with or without assistive devices; exclusion criteria: * severe concurrent illness or pain * recurrent autonomic dysreflexia * history of cardiovascular/pulmonary complications * concurrent physical therapy * pregnant at time of enrollment or planning to become pregnant * untreated painful musculoskeletal dysfunction, fracture or pressure sore * history of seizures or epilepsy * recurring headaches * concussion within the last six months * depression or manic disorder * metal implants in the head, or pacemaker * aversion to needles

Keywords: acute intermittent hypoxia spinal cord injury force steadiness
evaluations of cardiopulmonary function and motor development of congenital heart disease

Conditions: Congenital Heart Disease in Children; Infant Development; Infant Conditions; Motor Neuropathy; Motor Delay; Cardiopulmonary

Summary: in this single-center, randomized controlled trial, patients (4-8 months) with chd were randomly assigned to either a recovery group (home-based rehab exercise periodically) supervised by cellphone app or to a control group. left ventricular ejection fractions (lvef), the rate of increase in heart rate (rhri), and the rate of recovery heart rate (rhrr) were measured for representing cardiopulmonary capacity. the alberta test and neuro-intelligence scale were used to evaluate their motor developmental outcomes. this study verified the feasibility of this rehab method and indicated that 6-month home-based exercise training can improve cardiopulmonary endurance and motor developmental level in infant chd patients.


Eligibility criteria:
inclusion criteria: * chd infants (aged 4-8 months) with atrial septum defect (asd) or ventricular septum defect (vsd) exclusion criteria: * chromosomal abnormalities; family history of mental retardation; small for gestational age and prematurity; history of perinatal asphyxia and hyperbilirubinemia; history of central nervous system disease or imaging suggestive of brain dysplasia

Keywords: infant rehab management app home-based exercise cardiopulmonary endurance motor developmental level
effects of nmes on energy expenditure, glycaemia and hormonal responses to glucose ingestion

Conditions: Energy Expenditure; Metabolic Health

Summary: the purpose of this study is to investigate whether self-selected neuromuscular stimulation (nmes) affects energy expenditure, glycaemia and hormonal responses in healthy men and women

participants were asked to perform 3 trials \[sitting (sit), standing (stand) and sitting with neuromuscular electrical stimulation (nmes) to the lower limbs in randomised counter-balanced study design. trials were separated by at least 48 h and were completed within 14 days. in all trials, participants were required to remain relaxed and motionless. sit: participants sat in a chair with back, arms and legs supported. stand: participants were asked to stand with arms supported and feet spaced approximately 15 cm apart. if needed, adjustment of standing posture was allowed during the standing trial to prevent orthostatic hypotension. nmes: prior to the nmes trial, participants underwent preliminary testing to ensure that stimulation was comfortable. before the nmes, a small area of the body hair was shaved and skin was cleaned with an alcohol wipe and electrodes were stuck to the surface of the skin. small electrodes placed (5\*5 cm) on the lower limb of both legs (gastrocnemius, rectus femoris, vastus medialis). the two devices (em 80, beurer uk ltd, golborne, uk) were set up with the frequency of 20 hz along with stimulation period of 1 second on and 1 second off throughout a 2 h oral glucose tolerance test (ogtt). the instruction for nmes intensity was that the maximal intensity participants were be able to withstand for 2 hours whilst imagining sitting at home watching tv without feeling discomfort. prior to the ogtt, 5 min was given to identify the suitable intensity of stimulation and within the first 10 min of the ogtt participants were allowed to adjust the intensity once, after which, the intensity remained the same for the rest of ogtt. participants were asked to sit in a chair with back, arms and legs supported during the stimulation. during trials, participants could watch tv, or read, but typing on a laptop or computer were avoided.

Eligibility criteria:
inclusion criteria: * healthy men and women * aged between 18 to 65 years * weight stable for more than 3 months (no change in weight +/- 3%) * non-smoker exclusion criteria: * personal history of/existing diabetes, cardiovascular disease, metabolic disease or dyslipidaemia * taking medications that may influence lipid or carbohydrate metabolism or immune system function

Keywords: neuromuscular electrical stimulation insulin resistance standing glucose control