Kornimate/medical-research-clean huggingface dataset:
multimedia patient education

Conditions: Lung Cancer

Summary: objective: to compare changes in patient anxiety levels between groups of patients who either were or were not exposed to an informative multimedia patient education tool, in order to determine how the addition of such a multimedia tool will affect this parameter. specifically, the study will focus on subjective anxiety as measured on pre procedure and post procedure patient surveys as detailed under study components.

if you agree to take part in this study, you will complete a questionnaire that asks how you feel before the procedure. it will take about 5 minutes to complete. after you have completed the questionnaire, you will be randomly assigned (as in the flip of a coin) to group 1 or group 2. you will have an equal chance of being in either group. if you are in group 1, you will receive routine information before the lung biopsy and you will watch a video on a handheld or laptop machine with headphones. the video is designed to help you understand the biopsy procedure. this video should last about 5 minutes. you will then complete a questionnaire that asks how you feel after watching the video. it will take about 5 minutes to complete. if you are in group 2, you will receive routine information before the lung biopsy. you will then complete another questionnaire that asks how you feel before the procedure. it will take about 5 minutes to complete. after your routine lung biopsy, both groups will complete a questionnaire that asks how you feel after the procedure. it will take about 5 minutes to complete. for group 1, the total time to complete the questionnaires and watch the video will be 20 minutes. for group 2, the total time to complete the questionnaires will be 15 minutes. length of study: your participation in this study will be over once you complete the questionnaire after your lung biopsy. this is an investigational study. up to 100 patients will take part in this study. all will be enrolled at m. d. anderson.

Eligibility criteria:
inclusion criteria: 1. scheduled for a computed tomography (ct) guided lung biopsy 2. literate english-speaking exclusion criteria: 1. refusal to participate 2. current diagnosis of psychosis, dementia or other mentally altered state. 3. monitored anesthesia care (mac) or general endotracheal anesthesia (geta) during the procedure. 4. patients who are clinically diagnosed as hearing and visually impaired. 5. patients who have had prior image guided biopsies in our department.

Keywords: lung biopsy multimedia patient education tool multimedia education tool computed tomography guided lung biopsy computerized tomography ct questionnaire lung nodules
rtms combined with bwstt in stroke with body weight supported treadmill training (bwstt) after stroke

Conditions: Stroke

Summary: the study will enroll 5 individuals post-stroke to examine the feasibility and efficacy of a high frequency repetitive transcranial magnetic stimulation (rtms) combined with body weight supported treadmill training.

the purpose of this pilot study is to examine the feasibility and efficacy of 5hz repetitive transcranial magnetic stimulation (rtms) applied to bilateral motor areas as an adjuvant intervention to task-specific body weight supported treadmill training (bwstt) in individuals with subacute stroke. five individuals with a diagnosis of subacute stroke will be recruited and assigned to either high frequency or sham rtms group.both groups will receive a comprehensive assessment of their motor function, gait performance and neurophysiological function before the training. both groups will then go through a 10 week (24 sessions) of gait training with body weight supported treadmill. for the high frequency rtms group, they will receive 5 hz rtms applied to bilateral motor areas prior to each gait training session. for the sham rtms group, they will receive a sham stimulation prior to the gait training sessions. all participants will receive another comprehensive assessment after the training concludes. the assessor will be blinded to the intervention.

Eligibility criteria:
inclusion criteria: 1. 18-80 years old 2. \< 2 months post stroke at the time of enrollment 3. first time stroke: 4. able to walk \> 25 feet with or without assistive device and with no more than moderate assistance: 5. able to follow 1-step commands 6. able to communicate verbally exclusion criteria: 1. severe medical problems (e.g. recent cardiac infarct, heart failure, cancer) 2. presence of conditions that could affect gait training (e.g. amputation, severe arthritis) 3. bilateral stroke 4. non-ambulatory prior to stroke 5. bmi \> 40 6. any contraindications to tms (e.g. history of seizure, cardiac pacemaker, metal or magnetic implants) 7. pregnant or potentially to be pregnant
sedentary behavior and depressive symptoms

Conditions: Depression, Anxiety

Summary: depressive symptoms are commonly observed in the general population. individuals with subclinical forms of depression (e.g., not meet the criteria to major depression disorder) are at increased risk of mortality than the general population which is partially explained by the higher incidence of cardiovascular diseases. currently, the effectiveness of the frontline treatment for depression is not consensual. further, it also may be expensive for individuals with mild to moderate depression. sedentary behavior is an independent risk factor for cardiometabolic diseases and mental disorders. however, recent evidence suggests that not all types of sedentary behavior are equally detrimental. for instance, mentally passive sedentary behavior (e.g., watching tv) appear to be detrimental for health outcomes whereas mentally active sedentary behavior (e.g., desk-based office work) appear to offer health benefits. however, more studies are required to determine the magnitude of association between distinct types of sedentary behaviors (e.g., watching tv, listening to music, talking while sitting, sitting around and doing nothing special) with depressive symptoms as well as randomized clinical trials investigating potential benefits of interventions to replace mentally-passive sedentary behaviors with mentally active sedentary behaviors, light physical activity or moderate-to-vigorous activity in individuals with mild to moderate depression. therefore, the aim of this proposal is to investigate the influence of mentally passive sedentary behavior (i.e., watching tv, listening to music, talking while sitting, sitting around, and doing nothing special) on depressive symptoms. this is a randomized clinical trial. participants with mild to severe depressive symptoms will be randomly assigned (1:1) into either intervention or control group, using a computer-generated randomization code. depressive symptoms, quality of life, physical activity, sedentary behavior, body composition, and functionality will be assessed at baseline (pre) and 4 (post) months after the experimental period. the intervention group will participate in a 4-month goal-setting intervention aimed to replace mentally passive sedentary behaviors with mentally active sedentary behaviors, light physical activity, or moderate-to-vigorous activity while control group will receive general instructions related to who guidelines for physical activity.


Eligibility criteria:
inclusion criteria: * individuals aged over 17 years; * mild to severe depressive symptoms. exclusion criteria: * cancer in the past 5 years; * inability to perform the physical tests; * prior diagnosis of muscle degenerative disease (e.g., myopathies, amyotrophic lateral sclerosis);
application of hyaluronic acid in diabetes

Conditions: Periodontal Diseases

Summary: sub gingival application of hyaluronic acid create great clinical improvement of periodontal pocket treatment.

to clinically and radiographically evaluate the adjunctive effect of the local application of a 0.8% hyaluronan gel in addition to scaling and root planing in treatment of controlled diabetic patients with stage ii periodontitis.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years. * patient with controlled diabetic type 2 (hga1c \<7) (mori et al., 2021). * periodontitis stage ii. * periodontitis grade b. * pocket depth \> 4 mm. * smoking ≤ 10 cigarettes/day. * cooperative patients able and accept to come for follow up appointments exclusion criteria: * • the use of antibiotics or anti-inflammatory drugs 1 month prior to the procedure and till the end of 6 months of follow-up. * having surgical therapy or undergoing orthodontic treatment. * ongoing drug therapy that might have an impact on the clinical signs and symptoms of periodontitis. * pregnant and lactation females. * smoking ˃ 10 cigarettes/day. * patients with poor oral hygiene. * any known allergies
flexor tenosynovectomy to treat recurrent carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome

Summary: the purpose of this study is to collect data on the clinical and functional outcomes of surgical management for recurrent carpal tunnel syndrome (cts) using flexor tenosynovectomy. it is hypothesized that the outcomes of patients undergoing flexor tenosynovectomy for recurrent cts will compare favorably to published data regarding alternative types of surgeries for the same condition.

primary carpal tunnel release (ctr) is the most common surgical procedure of the hand, but reported rates of symptom recurrence are not uncommon. many surgical techniques have been proposed and reported for management of carpal tunnel syndrome (cts) symptom recurrence, however there is a paucity of data on flexor tenosynovectomy for management of recurrent cts. this study will evaluate clinical and functional outcomes using information from pre- and post-operative physical exams, surgery data, patient-reported satisfaction and symptoms, and scores on functional measures, such as the disabilities of the arm, shoulder, and hand (dash) questionnaire.

Eligibility criteria:
inclusion criteria: * adult patients (\> 18 years) * patient of the plastic surgery group/hayes hand center * previous diagnosis of carpal tunnel syndrome * diagnosis of recurrent carpal tunnel syndrome * underwent primary carpal tunnel release * undergoing isolated flexor tenosynovectomy as secondary procedure exclusion criteria: * had incomplete primary release of transverse carpal ligament * had documented neuroma upon re-exploration * had other soft tissue tumor within carpal tunnel or providing reasonable contribution to neurologic symptoms * experienced fracture or other traumatic injury to wrist after primary carpal tunnel release * diagnosis of osteomyelitis, infectious tenosynovitis or other infectious etiology to area of interest after primary procedure * diagnosis of rheumatoid arthritis, psoriatic arthritis, or other inflammatory arthropathy

Keywords: recurrent carpal tunnel release flexor tenosynovectomy
indocyanine green fluorescence uptake in human carotid artery plaque

Conditions: Atherosclerosis; Atherosclerotic Plaque; Carotid Stenosis

Summary: this will be a pilot study of 9 patients undergoing standard-of-care clinically indicated carotid endarterectomy. the nine patients will receive an injection of indocyanine green (icg) at a dose of 0.25 mg/kg (maximum 25 mg) as an intravenous bolus. immediately following endarterectomy, the resected specimen will be immersed in normal saline. ex vivo fluorescence reflectance imaging (fri) and immunohistochemistry will be performed. the investigators hypothesize that compared to controls, icg-injected patients will demonstrate increased ex vivo and microscopic icg fluorescence signal within areas of plaque.


Eligibility criteria:
inclusion criteria: * consecutive patients scheduled for elective carotid endarterectomy at massachusetts general hospital * age \> 18 years of age. * signed informed consent. exclusion criteria: * hemodynamic instability * any history of iodide allergy * any history of renal failure (estimated glomerular filtration rate (egfr) \<50 ml/min/1.73 m2) * any history of liver failure * any history of bleeding diathesis * any history of cerebral vascular accident in the preceding 3 months * pregnant or lactating females. * hx of seafood allergy

Keywords: atherosclerosis molecular imaging vascular biology inflammation fluorescence
rotavirus burden and genotypes in a sentinel hospital surveillance system in lebanon

Conditions: Gastroenteritis; Dehydration

Summary: this study aims to determine the contribution of rotavirus infection as a cause of gastroenteritis requiring hospitalization in children younger than 5 years of age. additionally, a secondary aim will be to determine the genotypes of rotavirus that cause these infections as prevalent in lebanon.

this study will be performed at six large hospitals in lebanon in the three largest cities beirut, tripoli, and saida. the study will enroll children younger than 5 years of age who are admitted to the hospital because of gastroenteritis. enrollment will continue for a period of two years at each hospital. inclusion criteria are age \< 5 years, with gastroenteritis as the main reason for admission to the hospital or for a stay in the emergency department longer than 12 hours. exclusion criteria include onset of symptoms beyond 12 hours of admission (health-care associated infection). for all enrolled subjects, data will be collected about severity of illness, outcome, and history of vaccination. stool samples will be collected for genotyping of rotavirus.

Eligibility criteria:
inclusion criteria: * age \< 5 years * gastroenteritis as admitting diagnosis * informed consent * parents willing and able to cooperate exclusion criteria: * age \> 5 years * onset of gastroenteritis beyond 12 hours of admission

Keywords: rotavirus gastroenteritis children pediatric dehydration vaccine
formula ptx renal stent clinical study

Conditions: Renal Artery Stenosis

Summary: the purpose of the study is to evaluate the safety and effectiveness of the ptx-coating on the formula ptx balloon-expandable stent in treatment of renal artery stenosis.


Eligibility criteria:
inclusion criteria: * renal artery stenosis * appropriate size and location of the lesion exclusion criteria: * pregnant or breast feeding * failure or inability to give informed consent * simultaneously participating in another drug or device study
a study to determine the efficacy of zpl-3893787 in subjects with plaque psoriasis

Conditions: Psoriasis

Summary: this was a randomized, double blind, placebo controlled, parallel group study in 129 subjects with moderate to severe psoriasis with a pasi score of at least 10. following run-in, subjects were randomized and received either oral 30 mg zpl-3893787 once daily or placebo once daily for 12 weeks.

this was a randomized, double blind, placebo controlled, parallel group study in 129 subjects with moderate to severe psoriasis with a psoriasis area and severity index (pasi) score of at least 10 and an investigator's global assessment (iga) of 3 (0-4 scale). following run-in subjects received either oral 30 mg zpl-3893787 once daily or placebo once daily for 12 weeks. subjects attended the clinic at baseline (day 0) when they were reviewed and confirmed they met inclusion/exclusion criteria. subjects were then randomized and received either oral 30 mg zpl-3893787 once daily or placebo once daily for 12 weeks.

Eligibility criteria:
inclusion criteria: * a documented history of moderate to severe plaque psoriasis for at least 6 months prior to screening. * male or female, aged ≥18 years. * psoriasis area and severity index (pasi) ≥10 at both screening and day 0. * an investigator's global assessment (iga) score ≥ 3 at both screening and day 0. * psoriasis affecting ≥10% body surface area (bsa) at screening and day 0. exclusion criteria: * current diagnosis of pustular, guttate, erythrodermic, exfoliative or only nail psoriasis or a diagnosis of inverse psoriasis without having plaque psoriasis. * concurrent skin disease (e.g. acne) of such severity in the study area that it could interfere with the study evaluation or presence of skin comorbidities that may interfere with study assessments. * active skin infections (e.g. impetigo, abscesses) or any other clinically apparent infections. * biologic treatments for psoriasis (e.g. enbrel, humira, stelara, cosentyx) within 3 months of the start of the run-in. * phototherapy (e.g. uva, uvb, puva) within 4 weeks of the start of the run-in. * oral calcineurin inhibitors and immunosuppressants (e.g. cyclosporine, azathioprine, methotrexate) within 4 weeks of the start of the run-in. * systemic corticosteroids within 4 weeks of the start of the run-in. * oral antihistamines and leukotriene inhibitors and tricyclic antidepressants within 1 week of the start of the run-in. * topical steroids (any potency), topical calcineurin inhibitors (tacrolimus, pimecrolimus), salicylic acid and urea containing treatments and coaltar preparations, topical and oral retinoids and vitamin d derivatives, within 1 week of the start of the run-in.
proof of concept study concerning efficacy of p03277 mr imaging in hcc diagnosis

Conditions: Chronic Liver Disease; HepatoCellular Carcinoma

Summary: this study is an exploratory study aiming to collect data about diagnosis efficacy (sensitivity and specificity) of p03277 triphasic liver imaging for hcc in subjects with suspected small nodules and chronic liver disease. 30 subjects will be included, having hcc confirmed or not by previous enhanced ct and/or mri and before any biopsy for histology analysis. the standard of reference for diagnosis will be given by the site according to their standard of care and adapted from easl/eortc diagnostic criteria (considering previous contrast enhanced imaging (ct and/or mri) and/or biopsy specimen analysis given on-site and/or the more recent afp results available). 10 additional subjects will be included to explore the diagnostic efficacy for hcc at half dose of p03277.


Eligibility criteria:
inclusion criteria: * subject presenting with liver cirrhosis or chronic liver disease as shown by previous liver biopsy or by combination of clinical, endoscopic, biological, ultrasound parameters, and elastography * subject presenting with 1 to a maximum of 3 untreated hepatic nodule(s) of less than or equal to 3 cm (long axis) previously identified and/or characterized through enhanced ct and/or mri within a maximum of 21 days before p03277 imaging, confirmed for hcc or not exclusion criteria: * subject presenting with hepatic nodule more than 3 cm in addition to nodule(s) less than or equal to 3 cm * subject already treated for hcc by surgery or thermal ablation for which the resection or coagulation area is less than 2 cm from the new nodule(s) * subject previously treated by transarterial chemoembolization * subject with moderate or severe renal impairment (egfr \< 60 ml/min/1.73 m2) based on measurement done or available within the 7 days before p03277 administration and assessed after any iodinated contrast agent administration, or with dialysis end stage renal disease (esrd)
iopth usefulness for predicting successful surgery in secondary hyperparathyroidism

Conditions: Secondary Hyperparathyroidism

Summary: secondary hyperparathyroidism (shpt) is a multisystemic syndrome that affects calcium and bone homeostasis in patients with chronic kidney disease (ckd). despite medical treatment, 1-2% of patients require parathyroidectomy anually. the use of an intraoperative paratohormone protocol (iopth) to predict cure still in debate, due to the lack of standardized protocols, the use of different assays and uneven pth clearance. the aim of this study was to determine the diagnostic accuracy of an iopth in patients with shpt for predicting successful surgery after parathyroidectomy.

a prospective observational study (cohort) was performed in patients who were submitted to parathyroidectomy by an endocrine surgeon for shpt. all were submitted to a bilateral neck exploration with a subtotal parathyroidectomy. three iopth determinations were withdrawn: at anesthetic induction (pth0), 15 minutes (pth15), and 30 minutes (pth30) after completion gland resection. another sample was taken 24 hours after the procedure (pth24), values \<150pg/ml defined a successful surgery and patients were assigned to the successful or unsuccessful group. iopth drop was analyzed to predict successful surgery with drops of 70% and 90% at 15 and 30 minutes.

Eligibility criteria:
inclusion criteria: * pth \>800pg/ml and shpt symptoms, or * asymptomatic patients with pth \>1000pg/ml who were resistant to treatment * compliance with the signature of the informed consent exclusion criteria: * patients who respond adequately to medical treatment * incomplete iopth protocol

Keywords: secondary hyperparathyroidism parathyroidectomy intraoperative paratohormone
cervical mobility and vestibular rehabilitation

Conditions: Vestibular Diseases

Summary: vertigo, dizziness and imbalance are the main symptoms of vestibular dysfunction. they can lead to physical consequences, such as the reduction of postural control and falls, psychological and / or psychiatric consequences such as anxiety and depression, panic and cognitive changes, especially in the elderly. it is known that individuals affected by these disorders may improve with the completion of vestibular rehabilitation protocol.treatment protocols can introduce variability of exercises to control the signs and symptoms related to vestibular diseases, in order to customize the treatment to affected individuals .

the objective of this study will be to compare the effectiveness of a multisensory exercises protocol of vestibular rehabilitation versus conventional protocol of cawthorne \& cooksey exercises for the treatment of patients with vestibular disorders. methods: there will be a clinical trial random, blind, hidden allocation. the sample will consist of 54 subjects submitted to two different protocols of vestibular rehabilitation exercises (intervention group (ig) and control group (cg)), to be held with individual treatment once a week, totaling 12 attendences. all will be assessed before and after treatment and the main variables analyzed are general characteristics of the clinical signs and symptoms caused by vestibular diseases, perception of quality of life and functional capacity paras activities of daily life, body flexibility, range of motion in the region cervical, parameters of static and dynamic postural balance and the perception of the results promoted by the treatment of vestibular rehabilitation and will compare the results of the groups. expected results: it is expected, clinically, that subjects who receive treatment through multisensory exercises protocol for vr present reduction of clinical signs and symptoms of dizziness, complaints of pains and cervical joint limitations, parameters of improvement related to postural balance, aspects of functional capacity and quality of life.

Eligibility criteria:
inclusion criteria: * people from the age of majority (18 years) to 69 years, considered by the population division in youth, adults and older people to 69 years according to the world health organization (who) , of both genders, with commitment by diagnosed peripheral vestibular disorders clinically by a doctor, including the peripheral vestibular type benign paroxysmal positional vertigo (bppv), with vestibular symptoms, with higher scores than or equal to a spot on the visual analogue scale (vas) dizziness or higher rank than or equal to 16 points in the questionnaire dizziness handicap inventory (dhi). exclusion criteria: * elderly aged 70 or more, which have visual impairment and/or total hearing, orthopedic disorders that limit the realization of the proposed activities, nervous system injuries that cause damage engines and/or additional sensitive and diagnostics of ménière's disease.

Keywords: rehabilitation physical therapy specialty postural balance vertigo dizziness