Kornimate/medical-research-clean huggingface dataset:
effect of hyaluronic-acid on the healing after free gingival graft

Conditions: Gingival Recession

Summary: this study evaluated the effect of topical hyaluronic acid (ha) application on free gingival graft (fgg) donor and recipient sites during the early wound healing period with laser doppler flowmetry (ldf) and to investigate the effect of ha application on the dimensional change of the graft.participants were randomly classified into the test group (tg) and control group (cg). ha was applied to both donor and recipient sites in 20 patients who formed the tg, whereas ha was not applied to the 20 patients who formed the cg.

the healing of a transplanted tissue depends on the formation of blood support between the donor and recipient sites. hyaluronic acid (ha) is a biomaterial that creates a favorable environment for wound healing due to its unique hydroscopic and viscoelastic properties, and it is important for wound healing activities.ha induces angiogenesis following degradation and improves the wound healing environment.ha supports a mechanism that induces proliferation of capillaries, and components produced after ha degradation increase vascularization.laser doppler flowmetry (ldf) technique is frequently used in the field of plastic surgery for monitoring microvascular blood flow to detect insufficient circulation in the skin transplants and flaps in the early period and to thereby prevent and predict possible surgical complications.

Eligibility criteria:
inclusion criteria: * clinically diagnosed inadequate attached gingiva exclusion criteria: * smoking
an open-label safety program for the use of zalcitabine (dideoxycytidine; ddc) in pediatric patients with symptomatic hiv infection who have failed or are intolerant to azt monotherapy, or who have completed other ddc protocols, or are ineligible for other ongoing clinical studies

Conditions: HIV Infections

Summary: to allow, on a compassionate use basis, zalcitabine (ddc) for pediatric patients with symptomatic hiv disease who have failed treatment or who are intolerant to zidovudine (azt), or who have completed other ddc protocols, or who are ineligible for ongoing clinical trials.

patients receive ddc and are evaluated at study entry and every 3 months thereafter, until 3 months after ddc becomes approved for pediatric patients or the sponsor deems it necessary to terminate the protocol.

Eligibility criteria:
inclusion criteria patients must have: * symptomatic hiv infection. * failure on or intolerance to azt monotherapy or completed other ddc protocols or been ineligible for other ongoing clinical trials. * consent of parent or guardian required. note: * patients who do not meet the eligibility requirements may discuss their cases with the medical monitor.

Keywords: zalcitabine acquired immunodeficiency syndrome aids-related complex
the effects of exercise in end-stage renal disease patients undergoing hemodialysis

Conditions: End Stage Renal Failure on Dialysis

Summary: we aimed to investigate the effect of a progressive resistance training and aerobic training protocol on functional capacity, body composition and quality of life.

subjects were randomized into group a and b: group a (n=30) exercised for the first 6 months while group b (n=31) performed a placebo exercise initially (3 months) and cross-over to aerobic exercised for 3 months more.

Eligibility criteria:
inclusion criteria: * older than 18 years * more than three months of hemodialysis vintage * under the permission of their nephrologist * agreement to be randomly assigned and undergo study protocols exclusion criteria: * patients in wheelchair, presenting disability, or those who had amputation and malformation of the lower limbs, causing impaired walking * presenting representative blindness
feasibility study of a diary for allogenic hematopoietic stem cell transplantation patients and families

Conditions: Hematopoietic/Lymphoid Cancer; Psychological Disorder

Summary: allogenic hematopoietic stem cell transplantation is a specific time during hematological disease management for the patients, theirs relatives and the healthcare team. this heavy treatment is most of the time the last possible curative therapy and could cause many side effects such as infectious diseases and graft versus host reaction. the protective isolation is also a source of physical and psychological isolation. published studies reported depressive syndrome, anxiety symptoms and post-traumatic stress disorders for patients and their families. since 10 years ago, diaries are used in intensive care unit to limit these symptoms after a coma. in analogy, the diary for the patients with allogenic hematopoietic stem cell transplantation could be a mean to reduce the psychological adverse impact and long terms consequences. the investigators want to evaluate the psychological impact of a diary on the patients hospitalized for allogenic hematopoetic stem cell transplantation and on their relatives.


Eligibility criteria:
inclusion criteria: * patient age \> 18 years * patient hospitalized for an hematopoietic allogenic stem cell transplantation * patient agreeing to participate exclusion criteria: * patient not hospitalized for an hematopoietic allogenic stem cell transplantation

Keywords: allogenic hematopoietic stem cell transplantation diary psychological disorders
genetics of autoimmunity in type i diabetes

Conditions: Type1diabetes; Diabetes Mellitus, Type 1; Type1 Diabetes Mellitus; Diabetes Mellitus

Summary: the purpose of this study is to gain more information about the step-by-step process that causes someone to develop type 1 diabetes. scientists think that a person's own immune system, directed by genetic and environmental factors play a major role in its development. participation involves a blood draw, a brief medical history questionnaire and measurements of height and weight. some participants will be asked to return for annual follow-up visits for 10 years.

the goal of this project is to gain knowledge about the development of type 1 diabetes (t1d), as t1d is one of the most common chronic diseases in children. there has been a rise in the number of cases diagnosed as well as a decrease in the age of diagnosis. this project aims to understand the disease progression as seen in the immune system and to define the genetic and environmental factors that affect inflammation and regulation, which could determine disease progression or nonprogression. families that include a family member with t1d will be recruited, as well as unrelated, healthy controls as a comparison group. participants will have height and weight measured, complete a social \& medical history questionnaire, and have blood drawn for analysis for hla haplotype (a genetic sequence related to type 1 diabetes susceptibility)diabetes, blood glucose, immune system response, complete blood count, and autoantibody measurements. some family members may return for follow-up visits for up to 10 years.

Eligibility criteria:
inclusion criteria (families): * families where at least one first-degree family member has type 1 diabetes * the diabetic proband in the family was diagnosed before the age of 39 * family members must be at least 2 years old to participate exclusion criteria (families): * families with no history of type 1 diabetes * families with a history of diabetes that is not type 1 (lada, mody, type 2 etc.) inclusion criteria (controls): * no family history of type 1 diabetes or other autoimmune conditions * age 2 or older exclusion criteria (controls): * personal or family history of autoimmune disease

Keywords: family healthy controls siblings
virtual reality, pain, clinical outcomes, hydrotherapy, children, burn

Conditions: Burn; Hydrotherapy

Summary: this study aims to evaluate the effect of virtual reality on pain and clinical outcomes during hydrotherapy for children with burn.


Eligibility criteria:
inclusion criteria: * aged from 3-6 years. * children who do not have a burned face. * undergoing hydrotherapy procedure for wound care. * able to score their own pain, with or without a visual tool. * willing to participate in the study. exclusion criteria: * are cognitive or visual impairment. * received strong pain killer or sedative medication.

Keywords: virtual reality pain clinical outcomes hydrotherapy children burn
spinchip hs-ctni multisite precision

Conditions: Acute Myocardial Infarction (AMI)

Summary: during a heart attack, the protein troponin i is released from the heart muscle into the bloodstream. measurements of cardiac troponin in blood are used as an aid in the diagnosis of heart attack. the spinchip hs-ctni test is a new high-sensitive test for measuring the amount of cardiac troponin i in the bloodstream as an aid in the diagnosis of heart attack. the purpose of this study is to establish the precision of the spinchip hs-ctni test when using li-heparin plasma and whole blood samples in the hands of the intended user in the intended use setting at multiple sites.

cardiac troponins are widely used as a biomarker to aid in the diagnosis of acute myocardial infarction (ami). these structural proteins are essential in regulating contraction in cardiac muscle cells, and they are sensitive and specific biochemical markers of myocardial damage. during a heart attack, cardiac muscle cells are injured and release the cardiac marker troponin i (ctni) into the bloodstream. high-sensitive troponin tests may detect the increase of cardiac troponin in blood within hours after the symptoms of a heart attack has started. the spinchip high-sensitivity cardiac troponin i (hs-ctni) test is a new high-sensitive test for measuring troponin i in blood samples, and the analysis may be performed close to the patient (near-patient test). the results may be obtained within 10 minutes, compared to approximately 1 hour for normal laboratory analysis. the spinchip platform consists of the spinchip hs-ctni test and the spinchip analyzer and may be used at the emergency department to evaluate patients presenting with symptoms of acute myocardial infarction (chest pain). the test can use blood from finger prick or venous blood samples, either as whole blood or separated into plasma. this multisite prospective, observational, non-randomized validation study will establish the repeatability, within-laboratory precision and reproducibility of the spinchip hs-ctni test for li-heparin plasma and repeatability for li-heparin whole blood samples. potential subjects will be identified based on clinical cardiac troponin levels obtained from medical records at the individual study site.

Eligibility criteria:
inclusion criteria: * able and willing to provide signed written informed consent * subjects \>18 years old * clinical ctn concentrations available exclusion criteria: * cognitive impairment precluding informed consent * self-reported pregnancy * general clinical condition that affects the patient in a major way and the patient is considered to be in an unstable clinical condition * previously included in the study with a sample within the required concentration ranges for the spinchip hs-ctni test * no venous blood sample collected for the study

Keywords: acute myocardial infarction high-sensitive point of care troponin i near-patient test heart attack diagnostic accuracy
hartmann's versus primary anastomosis in left-sided colon perforation

Conditions: Surgery; Diverticulitis; Neoplasms; Postoperative Complications

Summary: the purpose of this multi-center randomized trial is to identify any differences in the complication rates of patients undergoing hartmann's (end colostomy) versus primary anastomosis (with defunctioning ileostomy) for left-sided colonic performation (including the stoma reversal operation).

hartmann's operation: the surgical resection of the rectosigmoid colon with closure of the rectal stump and end colostomy. end colostomy: a stoma is created from one end of the bowel while the other portion of the bowel is either removed or sewn shut (hartmann's pouch). the second operation (reversal) requires a colo-rectal anastomosis. primary anastomosis: colonic resection with primary anastomosis and defunctioning ileostomy. the second operation (stoma reversal) requires an entero-enteral anastomosis. anastomosis: is to join together two bowel ends to restore continuity after resection or stoma formation. colostomy: is a reversible surgical procedure in which a stoma is formed by drawing the healthy end of the colon through an incision in the anterior abdominal wall and suturing it into place. this opening, in conjunction with the attached stoma appliance, provides an alternative channel for feces to leave the body. ileostomy is a surgical opening constructed by bringing the loop of small intestine (the ileum) out onto the surface of the skin.

Eligibility criteria:
inclusion criteria: * patient age \> 18 years * left-sided colon perforation * german language speakers exclusion criteria: * patient age \< 18 years * perforation outside of the left-colon * bowel obstruction/disease without perforation * evidence of metastasis

Keywords: emergency surgery bowel perforation diverticulitis neoplasms postoperative complications randomized controlled trial
trial of oxytocin alone versus oxytocin and propranolol for the treatment of abnormal labor

Conditions: Dysfunctional Labor

Summary: the purpose of this study is to determine whether propranolol is better than oxytocin for the treatment of labor abnormalities. the endpoint is the rate of vaginal delivery experienced by women receiving prolonged oxytocin versus propranolol.

this trial was designed to test if propranolo can reduce the c section rate for dysfuctional labor. due to stringent inclution and exclusion criteria and low enrollment the study was closed.

Eligibility criteria:
inclusion criteria: * must be term pregnancy (\> 37 weeks) * vertex presentation * active labor (4-5 centimeters dilated) exclusion criteria: * heart disease * diabetes * currently taking propranolol * contraindications to labor or vaginal delivery * multiple gestations * preterm * chorioamnionitis

Keywords: labor dysfunctional labor labor arrest primary cesarean section prevention
peripheral nerve stimulation to improve upper extremity function after severe stroke

Conditions: Stroke

Summary: subjects will receive non-invasive stimulation of nerves on their arm and intensive motor training of their arm. the timing of the stimulation in relation to the training will vary by group.

this study will look at the differences in improvement of hand and arm function when nerve stimulation is applied at different times in relation to motor training. the nerve stimulation, called peripheral nerve stimulation (pns), is non-invasive and painless. subjects in the study may receive strong or mild pns. subjects will also vary by whether pns is delivered for 2 hours before the 2 hours of motor training, or during the 2 hours of motor training. which level of stimulation and its timing will be determined randomly for each subject.

Eligibility criteria:
inclusion criteria: * have severe upper extremity motor deficit after a single stroke * stroke onset at least 12 months ago exclusion criteria: * addition or change in the dosage of drugs known to exert detrimental effects on motor recovery within 3 months of enrollment * untreated depression * history of multiple strokes * history of seizure * history of head injury with loss of consciousness, severe alcohol or drug abuse, or psychiatric illness * positive pregnancy test or being of childbearing age and not using appropriate contraception * presence of ferromagnetic material in the cranium except in the mouth, including metal fragments from occupational exposure, and surgical clips in or near the brain * cardiac or neural pacemakers or implanted medication pumps * receptive aphasia

Keywords: neuroplasticity rehabilitation peripheral nerve stimulation motor training
a blood test to diagnose sepsis in symptomatic adults and children

Conditions: Infections; Sepsis; SIRS

Summary: a case-control cohort study to develop and validate the performance of a whole blood gene expression test to distinguish sepsis infection from uninfected systemic inflammatory response syndrome cases in symptomatic adults and children without comorbidities.

the purpose of this prospective, non-interventional study is to develop and validate a blood gene expression test for diagnosing the cause of sepsis in adults and children with symptoms of infection. sepsis affects 31.5 million people globally leading to 5.3 million deaths each year. sepsis is particularly harmful to immunodeficient patients undergoing cancer therapy with 3.7 percent to 6.4 percent of cancer patients diagnosed with sepsis in the us in their first year after cancer diagnosis. current tests to diagnose the infectious cause of sepsis rely on blood cultures which takes 24-48 hours to complete; leading to delays in early treatment critical to reduce the risk of developing sepsis shock and possibly death. in addition, around 50 percent of severe sepsis cases are culture negative, confounded acute infections not detected in the blood, by viral infection or uninfected patients exhibiting systemic inflammatory response syndrome (sirs). since sepsis often progresses to sepsis shock within 72 hours, suspected sepsis cases are usually immediately treated with antibiotics until results from testing distinguish the cause of symptoms. this leads to the over-use of antibiotics and delays appropriate treatment for those without bacterial infection or un-infected sirs. a quick and accurate diagnostic blood test may enable early discrimination of the cause of sepsis resulting in faster more appropriate treatments and reduced sepsis complications and death. the study will collect blood samples from participants presenting symptoms of acute infection, without co-morbidities and follow symptom severity and mortality for 28 days.

Eligibility criteria:
criteria: inclusion criteria: * clinical suspicion of an acute infectious disease * presence of at least one of the following: 1. temperature ≥ 38°c or temperature ≤ 36°c 2. heart rate \> 90 bpm 3. respiratory rate \> 20/min 4. self reported fever/chills * symptom duration ≤ 7 days exclusion criteria: * received antibiotics or antivirals in the past 2 weeks. * previous infection in previous 2 weeks * primary or secondary immunodeficiency * proven or suspected hiv, hepatitis b or hepatitis c infection * current immune-suppressive or immune-modulating treatment * active hematological malignancy * other illnesses that affect life expectancy

Keywords: acute infection fever without source viral infection
transcutaneous electrical nerve stimulation and interferential currents in chronic low back pain

Conditions: Chronic Low Back Pain

Summary: the purpose of this study was to compare the effects of the tens and ifc in patients with non specific chronic low back pain.

setting outpatient physiotherapy department in university (cesumar) participants a hundred and fifty patients with non specific chronic low back pain with or without radicular pain. interventions the patients were randomly divided into three groups: 1) tens; 2) ifc; e 3) control. ten sessions of electrotherapy for groups 1 and 2, while the patients of the control group stayed without any treatment in the same period main outcome measures intensity of the pain through the visual analogue scale and mcgill pain questionnaire; specific functional disability by roland morris disability questionnaire; analgesic period (hours); and the medication consumption statistic analysis all data were analyzed using statistica version 7 and sas version 9.1. baseline characteristics were compared using the shapiro-wilks test for continuous variables and then analysis of variance for measuring independent data. the characteristics of the patients who finished the treatment were compared with those of the lost patients, using one-way anova and the kruskal-wallis test.

Eligibility criteria:
inclusion criteria: * individuals who had had low back pain for less than three months exclusion criteria: * individuals who were receiving treatment for their pain with another method at the same time, except for medicines; * pregnant women; * patients who had undergone vertebral column surgery (less than three months before the time of this study); * individuals with contraindications against electrotherapy, such as skin lesions, abnormal sensitivity, infectious and blood diseases, heart pacemakers or inability to answer questionnaires; * patients with fibromyalgia; * individuals with psychiatric problems; * individuals who refused to participate or were unwilling to follow a protocol lasting for two weeks.

Keywords: rehabilitation electrotherapy back pain
hypoglossal acupuncture for dysgeusia in patients undergoing chemotherapy

Conditions: Acupuncture; Taste Disorders; Dysgeusia; Chemotherapy; Cancer

Summary: this randomized controlled trial aims to investigate hypoglossal acupuncture in comparison to sham acupuncture and standard medical treatment (dietary recommendations) in the treatment of dysgeusia in cancer patients undergoing chemotherapy.

taste disorders are frequent side effects in patients undergoing chemotherapy (ctx). dysguesia has prevalence rates of 16% to 1000% during ctx with sometimes also persistent courses. impact of dysguesia on appetite, body weight as well as health-related quality of life was shown. until now, evidence for adequate treatment options is limited to specific diary recommendations. acupuncture in the treatment of side effects of chemotherapy was investigated for nausea and xerostomia, but not for dysguesia. therefore, this randomized controlled trial aims to investigate hypoglossal acupuncture in comparison to sham acupuncture and standard medical treatment (dietary recommendations) in the treatment of dysgeusia in cancer patients undergoing chemotherapy.

Eligibility criteria:
inclusion criteria: * initial treatment with platinum-containing or taxane-based ctx (regardless of the the length of the ctx cycle) * senological, gynecological or internistic tumors * phantogeusia (on average ≥4 nrs) * willingness to participate in the study and written informed consent exclusion criteria: * severe stomatitis * dysgeusia before the ctx based on neurological diseases, diabetes, or the ingestion of drugs with taste disorders as side effects * leucopenia/neutropenia * intake of anticoagulants * smoking * severe physical or mental comorbidity (due to which the patient is unable to participate in the study) * participation in other cam treatments within the integrative oncology care * participation in other studies on the effectiveness of interventions for oral complications
duration of vitamin d stores after prolonged vitamin d substitution

Conditions: Obesity

Summary: ingested or skin produced vitamin d is either hydroxylated in the liver to 25-hydroxyvitamin d (25(oh)d), metabolized and excreted in the urine, or stored in adipose and other tissues. the capacity for vitamin d storage in adipose tissue is not known, nor the importance of such storage which may potentially be of vital importance when intake or solar exposure is limited. in the present study we will include 76 subjects who have participated in an intervention study with vitamin d (20.000 iu per week) versus placebo for the prevention of type 2 diabetes, and who have completed the study after 5 years or who have been excluded because of diagnosed type 2 diabetes or for other reasons. if vitamin d is stored to any extent in the body the subjects given 20.000 iu vitamin d per week for 2-5 years will have a considerable amount of stored vitamin d and accordingly, a slow decline in serum 25(oh)d during the following year without vitamin d substitution, which will be measured in the present study. if our hypothesis is correct, that vitamin d can be stored in significant amounts when the supply is abundant; current advice on vitamin d supplementation mainly during winter should be changed to "year around" in order to build up sufficient stores for the months without sufficient sun light.


Eligibility criteria:
inclusion criteria: * previously participated in a vitamin d study exclusion criteria: * pregnancy

Keywords: vitamin d fat biopsy