Kornimate/medical-research-clean huggingface dataset:
echocardiographic screening of pregnant women during antenatal care

Conditions: Valvular Heart Disease; Rheumatic Heart Disease; Pregnancy Complications

Summary: non-obstetrical drivers of adverse pregnancy outcomes are underappreciated. latent structural heart disease may account for a substantial proportion of adverse pregnancy outcomes in low-resource settings. pregnant women presenting to b.p. koirala institute of health sciences will be prospectively included into a registry upon their visit for antenatal care. women will be followed until 6 weeks after the time of delivery. nested within this registry, the investigators will perform a registry-based adaptive cluster randomized crossover trial. the trial compares an experimental condition (echocardiographic screening) and a control condition (routine antenatal care).

latent structural heart disease may result in complications during pregnancy and delivery. echocardiographic screening of pregnant women allows for timely detection of structural heart disease in women that may complicate delivery and jeopardize the health and well-being of both the mother and the newborn. in a setting of high rates of latent rheumatic heart disease, with particular high prevalence among women, systematic echocardiographic screening may be a pragmatic approach to prevent adverse clinical outcome related to valvular heart failure. systematic echocardiographic screening proved to be effective among children in endemic regions. the present study is a registry-based, adaptive cluster randomized crossover trial. the trial will be nested into a registry of pregnant women presenting for routine antenatal care. the experimental condition will be echocardiographic screening. the control condition will be no echocardiographic screening. in the experimental condition, all pregnant women presenting for routine antenatal care will be offered transthoracic echocardiographic screening for the detection of latent structural heart disease. in the control condition, pregnant women will undergo routine antenatal care with echocardiography only when clinically indicated. ascertainment of the primary endpoint will be performed at hospital discharge after delivery and will rely on routinely collected data. all events will be independently adjudicated by an expert panel of pediatricians, cardiologists and gynecologists. the randomization relates solely to the detection of rheumatic heart disease, while treatment follows guideline recommendations. it is important to note, that all women both in the experimental arm and the control arm detected to have heart disease will undergo optimal medical management during pregnancy and delivery according to the most recent guidelines.

Eligibility criteria:
inclusion criteria: * pregnant women ≥18 years presenting for routine antenatal care. * written informed consent. exclusion criteria: * women presenting to the hospital after delivery. * women presenting directly for delivery without previous antenatal care.
electromyographic (emg) biofeedback training in zone i-iii flexor tendon injuries

Conditions: Flexor Tendon Rupture; Hand Therapy

Summary: aim: the aim of the study was to investigate the effect of electromyographic (emg) biofeedback training applied in addition to early passive motion protocol on electrical muscle activity (ema) and functional status in zone i-iii flexor tendon injuries. materials and methods: cases who underwent surgery for flexor tendon injuries in zone i-iii were included in this prospective randomized controlled trial. cases were randomly divided into two groups of 11 cases each by block randomization. in the first group, emg biofeedback training was applied in addition to the early passive motion method (modified duran protocol), while the second group was followed only by early passive motion method. the treatment program was performed by the same physiotherapist three times a week, for 12 weeks. at the postoperative 5th, 12th and 24th weeks, joint range of motion (rom) and ema were evaluated, and the michigan hand outcome questionnaire (mhq) was administered to the patients. the grip strength at 12th and 24th weeks were also assessed. the mann-whitney u test was used to compare the two groups.


Eligibility criteria:
inclusion criteria: * being olunteer, * no history of neurological, orthopedic, rheumatologic disease or trauma in the related extremity, * no history of neuropathy due to a metabolic disease (diabetes, etc.), * incision of at least one of the fds or fdp tendons, * at least one of the fds or fdp tendons repaired within 2 weeks after the injury, * no communication problems. exclusion criteria: * \<18 years of age, * pregnancy, * thumb flexor tendon cuts, * digital nerve injury, * accompanying fracture, joint capsule injury or skin loss, * crush injury, * patients with pacemakers, * patients with cardiac arrhythmias, * epilepsy.
high intensity interval training after stroke

Conditions: Stroke

Summary: the purpose of this study is to examine if high intensity interval training after stroke is more effective than standard care to increase maximal oxygen uptake, reduce known risk factors for recurrent stroke and improve function.

stroke is a leading cause of adult disability. well designed studies have shown that the majority of the stroke population have low aerobic capacity and many are inactive. this is negative for their health and well-being. physical inactivity may increase their risk of having recurrent stroke. the optimal training mode and intensity to improve aerobic capacity after stroke are not clear. high intensity interval training (ie. 90-95% of peak heart rate) has been proven to be more beneficial than moderate and low intensity exercise in order to improve maximal oxygen uptake in patients with cardiac disease. the response from this training on aerobic capacity and physical function in the stroke population are not known.

Eligibility criteria:
inclusion criteria: * approved informed consent * independent walking \> 2 minutes * first episode of stroke (ischemic or hemorrhagic) * minimum 3 months post-stroke * living in the community and able to travel to assessment and training site * approval to participate from the study's responsible medical doctor * modified rankin scale 0-3 exclusion criteria: * impaired cognitive function to give valid informed consent to participate * instability of cardiac conditions (ie. serious rhythm disorder, valve malfunction) * other conditions where test of maximal oxygen uptake is contraindicated * poorly controlled hypertension (\>180/100), measured at rest * \> 5 years post stroke * subarachnoid hemorrhage * participating in other ongoing intervention study * other serious illness influencing testing of cardiorespiratory fitness and function at 1 year follow-up

Keywords: exercise training oxygen consumption
respiratory covid-19: a randomized, sham-controlled study

Conditions: COVID-19 Pneumonia; Acute Respiratory Distress Syndrome; COVID-19 Acute Respiratory Distress Syndrome; COVID-19 Respiratory Infection

Summary: a study of intubated critically ill patients infected with sars-cov-2 to evaluate the safety and treatment effects of ultraviolet-a (uva) light administered by a novel device via endotracheal tube in a first-in-human study. study hypothesis was that respiratory sars-cov-2 viral burden would significantly decrease following five (5) days of uva therapy.

the uv respiratory tract light therapy device is intended to emit energy in the uva region of the spectrum in intubated patients to reduce the viral burden of sars-cov-2 (human pathogenic coronavirus (covid-19)) in intubated patients. the system is to be used in conjunction with the current standard of care measures. the uv respiratory tract light therapy device is intended to be used for 20 minutes per 24-hour period for the endotracheal application for 5 days, in combination with pharmacological and/or physical measures to optimize the therapeutic outcome.

Eligibility criteria:
inclusion criteria: 1. patients over 18 years of age 2. confirmed positive test result for sars-cov-2 within 14d 3. mechanically ventilated (first intubation since positive sars-cov-2 test) 4. endotracheal tube inner diameter at least 7.5 mm exclusion criteria: 1. unable to provide informed consent (or surrogate) 2. enrolled in a therapeutic clinical trial for covid-19 that does not allow recruitment in other trials. 3. pregnant women. while not an exclusion criterion, special care should be exercised in treating patients who are receiving concomitant therapy (either topically or systemically) with known photosensitizing agents such as anthralin, coal tar or coal tar derivatives, griseofulvin, phenothiazines, nalidixic acid, fluoroquinolone antibiotics, halogenated salicylanilides (bacteriostatic soaps), sulfonamides, tetracyclines, thiazides and certain organic staining dyes such as methylene blue, toluidine blue, rose bengal, and methyl orange.
perioperative administration of pregabalin for pain after septoplasty

Conditions: Deviated Nasal Septum

Summary: pregabalin is used for the treatment of neuropathic pain and has shown analgesic efficacy in postoperative pain. the aim of this randomized, double-blinded, placebo-controlled trial was to investigate the efficacy and safety of pregabalin for reducing postoperative pain in patients after septoplasty. persons who scheduled for elective septoplasty under general anesthesia were randomly assigned to groups that received either pregabalin (150 mg twice) or placebo, one hour before surgery and 12 hours after the initial dose. assessments of pain (verbal numerical rating scale) and side effects were performed at one, six, 12, and 24 hours postoperatively.

pregabalin is used for the treatment of neuropathic pain and has shown analgesic efficacy in postoperative pain. the aim of this randomized, double-blinded, placebo-controlled trial was to investigate the efficacy and safety of pregabalin for reducing postoperative pain in patients after septoplasty. patients will be randomly assigned to one of two groups to receive either pregabalin (lyrica®, pfizer, inc.) or placebo (vitamin complex). according to their assigned study group, patients received either pregabalin (75 mg) or placebo twice, one hour before surgery and 12 hours after the initial dose. the assessment of pain and side effects, such as nausea and vomiting, headache, dizziness, sedation, and blurred vision, were made at one, six, 12, and 24 hours postoperatively.

Eligibility criteria:
inclusion criteria: * age 20 ≥ and ≤ 65 years * patients with nasal packing after septoplasty exclusion criteria: * previous septal surgery history * postoperative complications including septal hematoma, bleeding ets. * current therapy with pregabalin, gabapentin, or any opioid * renal insufficiency * history of seizure disorder

Keywords: postoperative pain, nasal septum surgery, pregabalin
additional effect of visual feedback along with aot on balance,mobility and cognition in cp

Conditions: Cerebral Palsy

Summary: the study aims to find the effectiveness of visual feedback along with action observation therapy in cerebral palsy. the effect of aot on mobility, cognition and balance of the targeted population will be the intrest of the researcher


Eligibility criteria:
inclusion criteria: * without visual impairment and visual field defects * mini-mental state examination for children (mmc) score \>25 * gmfcs (gross motor function classification system) i-iii * children with modified ashworth scale (mas) less than 2 exclusion criteria: * unable to walk * children with severe co-morbidities

Keywords: action observation therapy cerebral palsy visual feedback
a non-drug study profiling cutaneous lupus

Conditions: Lupus Erythematosus, Cutaneous; Lupus Erythematosus, Systemic; Lupus Erythematosus, Discoid

Summary: the purpose of this study is to characterize the clinical and molecular profiles of patients with cutaneous lupus.

this is a phase 0, multiple-center observational study of biomarkers and clinical parameters in patients with lupus, including discoid lupus erythematosus (dle), subacute cutaneous le (scle) and active systemic lupus erythematosus (sle). there is no study-related therapeutic intervention and this protocol will not restrict or introduce any medical interventions including medications. study participants will undergo procedures that include collection of urine, blood samples, and skin biopsy. at least 30 participants (≥10 dle, ≥10 scle, and ≥10 sle) will be enrolled in this study. all participants will continue to be managed by their personal physicians per their standard of care. the data obtained in this study will help in the evaluation of new therapeutics for lupus and may facilitate lupus drug discovery. a blood sample for genomic analysis will be collected for research purposes from patients who provide consent and where local regulations permit. there will be a single sample collection time point for each patient. the safety assessments will include laboratory measurements (serum chemistry and hematology), monitoring of adverse events (aes) related to study procedures, and physical examination.

Eligibility criteria:
inclusion criteria: * have active dle or active scle confirmed by histological analysis * have a confirmed diagnosis of sle with sle disease activity index (sledai) of \>6 and current or historical positive ana or anti-dsdna * have an active skin lesion that can be biopsied * if using hydroxychloroquine or chloroquine, must be on stable doses for at least 2 months prior to screening. exclusion criteria: * have an active skin disease other than cle * have any known malignancy within the previous 5 years (with the exception of a non-melanoma skin cancer that has been treated with no evidence of recurrence) * have used a topical corticosteroid on active lesion * have donated blood (volume \>=500 ml) within 56 days prior to screening * has been treated with drugs that are associated with cle induction within 2 months prior to the screening * have been treated with \>10 mg/day prednisone therapy or equivalent in the last 4 weeks prior to screening.

Keywords: lupus erythematosus, subacute, cutaneous lupus erythematosus, systemic lupus erythematosus, discoid active cutaneous lupus erythematosus systemic cutaneous lupus erythematosus skin biopsy lesions
body image and physical activity of women with breast cancer

Conditions: Breast Cancer Female; Physical Inactivity; Quality of Life; Body Image

Summary: the goal of this self-initiated questionnaire-based follow-up clinical trial is to map the body image and physical activity of hungarian women treated for breast cancer. the main questions it aims to answer are: 1. how body image changes during different treatments among women treated for breast cancer? 2. how is physical activity among hungarian women treated for breast cancer?

the aim of our research is to assess the changes in physical activity and body image of women with breast cancer and the impact of these changes on their quality of life using subjective measures, through cross-sectional research and validation of the body image after breast cancer questionnaire in hungarian.

Eligibility criteria:
inclusion criteria: * adult women diagnosis of breast carcinoma exclusion criteria: * neuromuscular diseases * severe congenital musculoskeletal and other disorders * other surgical procedures within 1 year

Keywords: body image after breast cancer physical activity life quality
phase ii docetaxel / carboplatin / xrt + surgical resection in stage iii nsclc

Conditions: Lung Cancer; Carcinoma, Non-Small-Cell Lung

Summary: the purpose of this study is to assess how well this particular combination of chemotherapy, radiation and surgery works to help people with locally advanced lung cancer, how well pet scans indicates whether someone has responded to chemotherapy and radiation, and gene expression patterns related to outcomes in patients with locally advanced lung cancer who receive this treatment regimen.


Eligibility criteria:
inclusion criteria: histologically confirmed stage iiia or iiib nsclc * patients must have measurable disease * no previous chemotherapy, radiation therapy or other systemic therapy for their nsclc. * age\>18 years * life expectancy \>12 months * ecog performance status 0-1 * normal organ and marrow function * medically fit for surgery at time of enrollment. * women of childbearing potential and men must agree to use adequate contraception prior to study entry and for the duration of the study. women must have a negative pregnancy test prior to enrollment. * ability to understand and willingness to sign the consent form. exclusion criteria: * previous chemotherapy, radiation therapy or any other systemic treatment for their nsclc. * patients receiving any other investigational agents. * known metastatic disease (brain or any other site) * history of severe hypersensitivity reaction to docetaxel or other drugs formulated with polysorbate 80 or with allergic reactions to compounds of similar chemical composition to carboplatin or other agents used in the study. * peripheral neuropathy \>grade 1 * uncontrolled concurrent illness * pregnant women * weight loss\>10% in the past 3 months before diagnosis. * hyperglycemia - exclusion from pet analysis * hiv positive patients receiving combination anti-retroviral therapy because of possible pharmacokinetic interactions with docetaxel and carboplatin or other agents administered during the study.
the effect of tomatis auditory stimulation in children and adolescents with ndds

Conditions: Neurodevelopmental Disorders

Summary: the current study aims to explore the preliminary efficacy of the tomatis method on auditory processing in children with ndds.

this will be a two-arm, randomized controlled trial exploring whether the tomatis training could improve the components of auditory processing in children with neurodevelopmental disorders referred to a romanian child and adolescent psychiatric unit. outcomes assessment will be conducted at baseline (t1), immediately after the training (t2).

Eligibility criteria:
inclusion criteria: - neurodevelopmental disorder exclusion criteria: * intellectual disability

Keywords: tomatis children adolescents
the effect of precise aerosol inhalation nursing on sputum excretion in elderly patients with lung surgery

Conditions: Inhalation

Summary: comparing the effects of different kinds of aerosol inhalation nursing programs on effective sputum excretion in elderly patients with lung surgery.

based on the traditional oxygen aerosol inhalation treatment, this study will improve it. in the process, precise body position care, time control, observation and treatment, evaluation, etc. will be used to form a precise aerosol inhalation care plan. to explore the effect of this program on effective sputum excretion in elderly patients undergoing lung surgery.

Eligibility criteria:
inclusion criteria: * ①the patient underwent thoracoscopic lung surgery; ②there was no obvious pulmonary infection before the operation; ③good audiovisual function, no communication barriers, able to cooperate with nebulized inhalation operation; ④patients informed consent to this study. exclusion criteria: * ①patients with mental illness; ②acute copd; ③serious complications or failure of important organs after operation.
10-years follow-up of the examination trial

Conditions: Myocardial Infarction; ST Elevation Myocardial Infarction; Infarction; Necrosis; Heart Disease; Cardiovascular Diseases; Vascular Diseases

Summary: the examination trial was a superiority trial that compared everolimus-eluting stents (ees) versus bare-metal stents (bms) in an all-comer st-segment elevation myocardial infarction (stemi) population. the patient-oriented endpoint was not superior at 1-year, but it was at 5-year. however, very-long term follow-up is unknown. the study had an independent clinical event committee (cec). all events were adjudicated by an independent clinical committee, according to the academic research consortium 1.


Eligibility criteria:
inclusion criteria: * patients who were enrolled in the examination trial (nct00828087). exclusion criteria: * none.

Keywords: acute myocardial infarction primary percutaneous coronary intervention drug-eluting stent
efficacy and tolerability of levetiracetam add-on treatment in refractory pediatric patients with partial onset seizures

Conditions: Epilepsy

Summary: double-blind, randomized, placebo-controlled, multi-center clinical trial conducted to evaluate levetiracetam as adjunctive therapy in children (4-16 years) with refractory partial onset seizures.


Eligibility criteria:
inclusion criteria: * diagnosis of epilepsy with uncontrolled partial onset seizures, whether or not secondarily generalized, and the diagnosis was \>= 6 months before the selection visit * epilepsy was classifiable according to the ilae classification * \>= 4 partial onset seizures during the 4 weeks preceding the selection visit and were required to have \>= 4 partial onset seizures during each 4-week interval of the baseline period to qualify for randomization * unsatisfactory current aed treatment in terms of efficacy and/or safety * stable aed treatment consisting of no more than two aeds exclusion criteria: * treatable seizure etiology * epilepsy secondary to a progressive cerebral disease or any other progressively neurodegenerative disease, including rasmussen and landau-kleffner diseases * history of status epilepticus which required hospitalization during 3 months prior to the selection visit * history of or the presence of pseudo seizures * current diagnosis of lennox-gastaut syndrome

Keywords: levetiracetam keppra
effect of therapeutic touch on labor pain and hormone levels

Conditions: Therapeutic Touch; Childbirth

Summary: this study was conducted to determine the effect of sacral region-focused therapeutic touch applied during the latent phase of labour on hormone levels, labour comfort, and perception. a randomized sham controlled trial design was used in the study, which was conducted with 50 primiparous pregnant women. while therapeutic touch (25) focused on sacral region was applied in the intervention group, sham therapeutic touch (25) was applied in the control group. data were collected using a personal information form, the visual analogue scale, a hormone values follow-up form, the childbirth comfort questionnaire and the perception of birth scale. keywords: labor pain,therapeutic touch, childbirth, hormones

aim: this study was conducted to determine the effect of sacral region-focused therapeutic touch applied during the latent phase of labour on hormone levels, labour comfort, and perception. method: this randomised sham controlled experimental trial was conducted with two groups (intervention and control groups) in a state hospital between 08 march 2022 and 01 april 2023. the sample size of the study was calculated using the g\*power 3.1.9.6 programme. as a result of the calculation, twenty-five pregnant women for each group were included in the study. while therapeutic touch (tt) focused on sacral region was applied in the intervention group, sham therapeutic touch (stt) was applied in the control group. data were collected using a personal information form, the visual analogue scale (vas), a hormone values follow-up form, the childbirth comfort questionnaire (ccq) and the perception of birth scale (pbs). ibm spss v25 programme was used for statistical analysis of the study. the statistical significance was assessed at the level of p\<0.05.

Eligibility criteria:
inclusion criteria: * being primipara, * having a gestational age of 38-42 weeks, * planning to have a normal vaginal delivery, * having a 3-4 cm dilation in the latent phase, * having a single fetus and head presentation, * speaking and communicating in turkish, * agreeing to participate in the study, * having no high-risk pregnancy. exclusion criteria: * receiving induction, * receiving labor analgesia/anesthesia, * having sensitivity or problems with touch, * having to leave during the intervention due to some reasons such as medical procedures, etc.

Keywords: labor pain therapeutic touch childbirth hormones