Kornimate/medical-research-clean huggingface dataset:
radiation therapy with or without surgery in treating patients who have brain metastases

Conditions: Metastatic Cancer

Summary: rationale: radiation therapy uses high-energy x-rays to damage tumor cells in a single high dose. combining radiation therapy with surgery may be a more effective treatment for brain metastases. purpose: clinical trial to study the effectiveness of radiation therapy with or without surgery in treating patients who have brain metastases.

objectives: * develop prognostic factors for patients with brain metastases treated by focal treatment without concurrent whole brain irradiation. * determine whether focal treatment without whole brain radiotherapy produces good long-term outcome in patients with four or less cerebral metastases. * assess survival, physical and cognitive functioning, and quality of life of patients treated on this protocol. outline: quality of life is assessed using the fact-br scale, physical function is assessed using the fim scale, and cognition is assessed using two brief pencil and paper tests. patients receive focal therapy for cerebral metastases by any combination of (1) surgery plus fractionated stereotactic radiotherapy to surgical bed, or (2) single fraction stereotactic radiotherapy by linear accelerator with or without a radiation sensitizer. patients are followed at 2 and 10 weeks, then every 3 months for 18 months, then every 6 months for 3 years, then annually. quality of life is assessed at each followup visit. patients suffering intracerebral relapse are offered further focal therapy if they have no more than 3 metastases, no more than 6 lesions over consecutive scans, and continue to have life expectancy of at least 3 months and karnofsky performance status of 60-100%. otherwise, relapsed patients are offered whole brain radiotherapy or supportive treatment with steroids, and may also receive stereotactic boost to the new lesions. patients who have received prior whole brain irradiation will be offered entry into other protocols if eligible or supportive treatment with steroids. patients are followed as above. projected accrual: at least 60 patients will be enrolled in this study.

Eligibility criteria:
inclusion criteria: * biopsy, ct scan, or mri proven cerebral metastases with known current or previous systemic malignancy or * biopsy proven cerebral metastases other than from small cell lung cancer or lymphoma * refused whole brain radiation therapy or * received prior whole brain radiation therapy and ineligible for other relapse protocols * 18 and over * karnofsky 60-100% * life expectancy:at least 3 months * concurrent steroids allowed exclusion criteria: * more than four cerebral metastases on mri scan and suitable for focal treatment with surgery and/or stereotactic radiotherapy with a linear accelerator * more than 2 weeks since prior focal radiation * more than 2 weeks since prior focal surgery

Keywords: tumors metastatic to brain
the effect of bmi on gluteus maximum activity in adulthood with sacroiliac dysfunction

Conditions: Sacroiliac Joint Dysfunction; Obesity; EMG

Summary: purpose: this study will be conducted to investigate the effect of bmi on gluteus maximum activity in adulthood with sacroiliac dysfunction background: sacroiliac joint (sij) pain is pain arising from sij structures and sij dysfunction (sijd) generally refers to aberrant position or movement of sij structures . an estimated 15-30% of all low back pain cases are due to sij pain the present study will be conducted to add a new information to the body of knowledge of physical therapy profession as it will investigate the effect of bmi on gluteus maximum activity in adulthood with sacroiliac dysfunction hypotheses: . •there will be no effect of bmi on gluteus maximum activity in adulthood with sacroiliac dysfunction research question: * do bmi has an effect on gluteus maximum activity in adulthood with sacroiliac dysfunction?


Eligibility criteria:
inclusion criteria: - adulthood with sacroiliac dysfunction * their ages will range from 20-40 years old. * their bmi will be less than 20- 30kg/m2. * all of them suffer from mild to moderate degree of sacroiliac pain. * the subjects complain from sacroiliac pain for 1 month ago exclusion criteria: * exclusion criteria were a history of any of the following condition: * inflammatory diseases or any rheumatic disorders, * a history of vertebral fractures * surgical spinal fixation. * •any neurological disorders like ms
the surgical prognosis based diagnostic strategy for eosinophilic chronic rhinosinusitis

Conditions: Sinusitis; Nasal Polyps

Summary: previous studies have demonstrated that the eosinophilic inflammation of nasal mucosa is associated with the uncontrolled condition of chronic rhinosinusitis after surgery. however, the definition of the eosinophilic chronic rhinosinusitis is not very clear. japanese researchers have designed a scoring system to diagnose eosinophilic chronic rhinosinusitis. in this study, the investigators hope to examine the practicability of this scoring system and have a better knowledge of eosinophilic chronic rhinosinusitis in china.the retrospective study was conducted in a tertiary hospital. participants received functional endoscopic sinus surgery more than 1 years were called back for evaluation. a diagnosis cut off value of eosinophil count was determined by the surgery prognosis. then different factors were compared between participants with eosinophilic crs and those with non-eosinophilic crs to establish the appropriated diagnosis approach for eosinophilic crs.

the retrospective study was conducted in a tertiary hospital. participants received functional endoscopic sinus surgery more than 1 years were called back for evaluation. a diagnosis cut off value of eosinophil count was determined by the surgery prognosis. then different factors were compared between participants with eosinophilic crs and those with non-eosinophilic crs to establish the appropriated diagnosis approach for eosinophilic crs.

Eligibility criteria:
inclusion criteria: * diagnosis of chronic rhinosinusitis according to european position paper of rhinosinusitis and nasal polyps 2007. exclusion criteria: * immunodeficiency diseases, history of head and/or facial trauma, cancer or organ transplant recipients. * pregnancy or lactation. * acute respiratory tract infection within one month before the study. * patients without pathological samples. * antrochoanal polyp and cyst of the paranasal sinuses.

Keywords: chronic rhinosinusitis eosinophil surgery diagnosis
a randomized study comparing of three doses nebulized fentanyl in older adults

Conditions: Treatment Side Effects; Musculoskeletal Pain

Summary: this clinical trial compares three different nebulized fentanyl dosages for older persons experiencing severe musculoskeletal pain at the emergency department. the main objective is: does the effectiveness of nebulized fentanyl at dosages of 2 mcg/kg, 3 mcg/kg, and 4 mcg/kg at 30 minutes differ in older patients who report to the emergency room with pain from musculoskeletal injuries? secondary outcome are: 1. incidence of adverse effects after drug administration at minutes 0, 15, 30, 45, 60, 75, 90, 105, 120 2. incidence of receiving other pain relief treatments (rescue therapy) in minutes 30, 45, 60, 75, 90, 105, 120 participants will receive an explanation of the study and possible side effects, which may take approximately 5-10 minutes, without affecting the primary treatment of the patients. consent will be obtained in this study, along with signing or fingerprinting as evidence in the consent form.

participants will receive nebulized fentanyl for pain reduction at the pre-determined randomized dose, then researchers will follow up assessments of pain levels, vital signs, and any side effects at various intervals.

Eligibility criteria:
inclusion criteria: * age more than or equal 65 years old. * presented with musculoskeletal pain within 3 days. * pain score on verbal numeric rating scale ≥ 5. exclusion criteria: * patients need immediate intervention. * patients need acute rescue for acute coronary syndrome, respiratory failure, and stroke. * creatinine clearance \< 30 ml/min, cirrhosis stage iii, iv (present with ascites and varices). * trauma \>2 organ. * comorbidities of chronic obstructive pulmonary disease. * take mao inhibitors within 14 days. * history of opioid used within 8 hours. * history of alcohol or drug abuse. * history of fentanyl allergy. * patients with difficulty to communication (e.g. altered mental status, severe dementia (define by 6-items cognitive screening \> 12, language barrier).

Keywords: fentanyl opioid nebulized musculoskeletal pain elderly emergency room randomized controlled trial thai
efficacy of a non-invasive device for alleviation of parkinson's disease symptoms

Conditions: Parkinson's Disease

Summary: investigation efficacy of a non-invasive wearable electrostimulator device where the supplementary motor area, premotor area and/or subthalamic nucleus are stimulated bilaterally and extracranially.


Eligibility criteria:
inclusion criteria: * diagnosis of parkinson's disease * h\&y stage \>= 2 * existing bradykinesia symptoms * existence of one of the symptoms below * resting tremor * rigidity * walking disorder exclusion criteria: * cardiac pacemaker * psychiatric diagnosis * irregular heart/respiration rate * pregnancy * alcohol consumption * cardiovascular disease history * wearing an electro-active prosthesis * brain surgery history * ongoing tens/pens therapy

Keywords: motor symptoms
research on the correlation among magnetocardiography patterns and known cardiovascular risk factors in diabetic patients

Conditions: Diabetes Mellitus

Summary: the purpose of this study is to evaluate the correlation among magnetocardiography (mcg) patterns and various known cardiovascular risk factors.

it is well understood that diabetes mellitus (dm) causes various micro- and macrovascular complications. among them, coronary heart diseases (chds) claim most mortality, and diabetes has been considered as "chd equivalent". furthermore, the risk of chd has been noticed to increase in the pre-diabetic stage, suggesting the development of chd may start in a rather early stage of the disease. thus, early detection of chd in diabetic patients seems to be important. however, currently exam methods for chd in diabetic patients seemed to have their limitations. developed in the 1960s, magnetocardiography (mcg) is designed to detect the weak magnetic field generated by the electrical activity of the heart, and has been used widely in the study of fetal cardiac electrophysiology, arrhythmia and ischemic heart disease. however, the mcg pattern in diabetic patients is not fully understood. the aim of the study is to clarify the correlation among various cardiovascular risk factors and mcg pattern in diabetic patients. and, according to the results of the study, we'll evaluate the potentiality of mcg in early diagnosis of chd in diabetic patients.

Eligibility criteria:
inclusion criteria: * clear consciousness * met the diagnostic criteria of dm published by the american diabetes association in 2009 exclusion criteria: * not suitable for mcg exam (ex. with pacemaker implantation or indwelling metallic device)

Keywords: diabetes mellitus coronary heart disease magnetocardiography
risk stratification of patients with suspected covid-19 presenting to the ed

Conditions: COVID-19

Summary: descriptive study of patients with suspected covid-19 upon ed arrival of european hospitals between march 09 and april 08 2020. justification:

descriptive study of patients with suspected covid-19 upon ed arrival of european hospitals between march 09 and april 08 2020. justification: over the past 3 months, the world has faced a novel infection disease outbreak, due to a novel coronavirus, the severe acute respiratory syndrome coronavirus (sars-cov2), with a massive impact on healthcare resource. in europe, numbers of confirmed cases continue to rise. europe is currently one of the regions with the highest number of covid-19 cases and deaths due to this emergent diseases. most covid-19 infected patients present with mild to moderate acute respiratory symptoms, including cough, fever, dyspnea and pneumonia. about 20% will present with severe or critical manifestations of the disease, including pneumonia, respiratory failure and acute respiratory distress syndrome (ards). anticipating the needs for hospitalization in ward and/or intensive care is crucial. emergency departments are at the front line for triaging patients with suspected covid-19 and referring them to the appropriate level of care. in europe, the number of ed patients with suspected covid-19 is variable; rate of hospitalization from ed reaches 40% for this population. risk stratification and management decisions of patients presenting to the ed with suspected covid-19 is a challenge for emergency physicians.

Eligibility criteria:
inclusion criteria: adult patients (\>= 18 years old) attending the ed with a clinical suspicion of covid-19 based on the presence of the following criteria * fever \>= 38 °c * respiratory symptoms (dyspnea, cough, expectorations) * any other symptoms suggestive of covid-19 including digestive signs (diarrhea, anosmia...) exclusion criteria: * no insurance * patients less than 18 years
characteristics of nafld among type 2 diabetes patients

Conditions: Non-Alcoholic Fatty Liver Disease; Type2 Diabetes

Summary: type 2 diabetes patients have a high risk of developing nafld. this was confirmed during previous research, a high prevalence of nafld among type 2 diabetes mellitus patients was found. the investigators want to determine the characteristics of this population.


Eligibility criteria:
inclusion criteria: * 18-80 years, * having type 2 diabetes, * able to understand dutch, * able to understand the informed consent exclusion criteria: * excessive alcohol abuse, * other liver disease, * secondary causes of steatosis

Keywords: nafld nafld, characteristics type 2 diabetes hospital
socially isolated older adults living with dementia

Conditions: Alzheimer Disease; Dementia

Summary: the lack of efficacious research-based interventions for sexual and gender minority (sgm) older adults living with alzheimer's disease and other dementias, combined with the heightened risk of cognitive impairment in this population, presents a significant public health problem. sgm older adults are at elevated risk of social isolation and experience significant barriers to healthcare access. existing interventions for older adults with dementia have been found to be effective for caregiving dyads. yet sgm older adults, compared to heterosexuals, are significantly less likely to be married or to have biological family members to support them. a significant proportion of sgm older adults living with dementia have no caregiver or care network. the goal of the proposed research is to design and pilot test the cultural appropriateness, acceptability, and feasibility of an innovative translation of a personalized care network-rdad (reducing disability in alzheimer's disease) to support those living with dementia without a family caregiver, directly addressing unique sgm-specific risk factors.

we will address the following aims: aim 1. develop a personalized care network-rdad intervention suitable for sgm older adults living with dementia without caregivers. aim 2. implement a preliminary randomized controlled trial (rct) of 30 participants with 2 arms (routine medical care vs. the personalized care network-rdad approach) to assess the acceptability, feasibility, and initial efficacy of the intervention.

Eligibility criteria:
inclusion criteria: * age at enrollment is 50 years of age or older * self-identify as lgbt (or sexual or gender non-binary or same sex sexual behavior) * have early stage dementia, including alzheimer's disease or needs help with complex daily activities * living in the community, not in a care facility. exclusion criteria: * known terminal illness (with death anticipated within the next 12 months) * hospitalization for a psychiatric disorder in the 12 months prior to baseline * have more than early stage dementia * any physical limitations/chronic conditions preventing participation in an exercise program.

Keywords: lgbt
incidence of sleep-disordered breathing and upper airway collapsibility in postpartum patients and its intervention

Conditions: Sleep Disordered Breathing; Upper Airway Collapsibility; Upper Airway Obstruction

Summary: the investigators hypothesized that sleeping in a 45 degrees elevated body position decreases the likelihood of upper airway vulnerability to collapse early after delivery. furthermore, the investigators want to elucidate the anatomical and physiological risk factors that contribute in the upper airway obstruction in post-partum patients.

after obtaining study consent, each patient underwent measurements of upper airway cross-sectional area (csa) during daytime within 48 h after delivery. the minimum upper airway csa was measured using acoustic pharyngometry (eccovision acoustic pharyngometry; sleep group solutions, inc) in sitting, 45° elevated, and nonelevated upper body position. this method has been previously used and validated in pregnant women. in the patients who further gave consent for the sleep study, polysomnography (psg) was performed throughout the entire study night. within a crossover design, patients were randomly assigned to receive first either nonelevated or 45° elevated upper body position. position was changed after 3.5 h by a member of the team.

Eligibility criteria:
inclusion criteria: 1. postpartum mothers within 48 hours of delivery in a major academic teaching hospital. 2. age over 18 years. 3. admitted to the massachusetts general hospital ob service for the delivery. 4. interventions will be randomly assigned to the patients enrolled in this study exclusion criteria: 1. age under 18 years. 2. history of pre-existing pulmonary and cardiac diseases, including bronchial asthma, cystic fibrosis, chronic obstructive lung disease, neck and chest tumors (thyroid, mediastinal, etc.), irradiation to the neck and/or chest, and congenital airway deformities, other critically-ill conditions.
effect of quercetin supplementation on endometriosis outcomes

Conditions: Endometriosis

Summary: quercetin is a polyphenol compound that possesses anti-inflammatory properties and can be found in various food sources like apples, berries, cabbage, and onions. in park et al.'s study, it was discovered that quercetin led to a significant decrease in the proliferation of endometriosis cells. furthermore, quercetin also triggered apoptosis in endometriosis cells in vitro and reduced the size of endometriosis lesions in vivo. nevertheless, as of now, there have been no studies conducted in iran or worldwide that explore the effects of quercetin supplementation on individuals with endometriosis. hence, the aim of this study is to investigate the impact of quercetin supplementation on factors such as glycemic status, lipid profile, oxidative stress, inflammation, growth factors, adiponectin, sex hormones, and anthropometric indicators in women suffering from endometriosis.

the participants in the study were randomly assigned to two groups: the intervention group and the control group. the intervention group will receive two 500 mg quercetin tablets daily, after breakfast and lunch, for twelve weeks. on the other hand, the control group will be given a placebo. blood samples will be collected before and after the intervention to measure changes in blood lipid profile, fasting blood sugar, sex hormones (testosterone, estrogen, progesterone), tnfα, il-6, adiponectin, igf1, hba1c, shbg, fsh, lh, and plasma total antioxidant capacity.

Eligibility criteria:
inclusion criteria: * willing to cooperate and complete the informed consent form. * diagnosed endometriosis using laparoscopy and histopathological tests. * in the age group of 18 to 40 years. * having a regular menstrual cycle. * having a body mass index between 18.5 and 30. exclusion criteria: * using hormonal medications or intrauterine treatments for a minimum of three months prior to collecting a sample. * having immune system disorders, persistent infections, diabetes, or any conditions like polyps and fibroids within the uterine cavity.

Keywords: quercetin endometriosis inflammation gonadal steroid hormones anthropometric adiponectin growth factor metabolic factors
study to evaluate the safety and tolerability of gbt440 administered to subjects with ipf

Conditions: Idiopathic Pulmonary Fibrosis; Hypoxemia

Summary: this study is a randomized, double-blind, placebo-controlled trial in which eligible ipf subjects will be randomized to receive gbt440 or placebo orally daily.


Eligibility criteria:
inclusion criteria: * documented diagnosis of ipf. * oxygen desaturation with exercise. * completion of the baseline 6mwt * weight ≥ 50 kg * male or female of child bearing potential willing and able to use highly effective methods of contraception from study start to 3 months after the last dose of study drug. exclusion criteria: * fev1/fvc \< 70%. * subjects on supplemental oxygen therapy at rest. * history of other interstitial lung diseases. * significant polycythemia. * female who is breast-feeding or pregnant. * known current malignancy or history of malignancy within the last 2 years prior to screening. * use of cytotoxic and/or immunosuppressant medications within 30 days screening. * hospitalization due to an exacerbation of ipf within 30 days of screening * subject plans to begin or has commenced pulmonary rehabilitation within 30 days of screening * corticosteroids (\> 10 mg per day of prednisone or an equivalent) within 30 days of screening. * current smoker or history of smoking within 3 months of screening. * currently or, in the opinion of the investigator, soon to be listed for lung transplant. * history of unstable or deteriorating cardiac or pulmonary disease (other than ipf) within 6 months of screening. * any condition possibly affecting drug absorption. * participated in another clinical trial of an investigational drug (or medical device) within 30 days or 5-half-lives, whichever is longer, prior to screening, or is currently participating in another trial of an investigational drug (or medical device). * subject who, for any reason, is deemed by the investigator to be inappropriate for this study.
entamoeba gingivalis and periodontal disease

Conditions: Periodontal Diseases

Summary: this current study aims to clarify the relationship between the occurrence of entamoeba gingivalis infection and the specter of gingivitis \& chronic periodontitis among egyptian patients in comparison to healthy volunteers as a control group.

three groups will be included in the current study. 40 plaque samples will be collected from gingivitis patients (group 1), 40 from chronic periodontitis patients (group 2) plus 40 samples from healthy volunteers (group 3). diagnosis of parasitic stages will rely on direct microscopic detection using permanent stains, trichrome stain and haematoxylin and eosin stain in addition to direct wet mount examination.

Eligibility criteria:
inclusion criteria: * chronic gingivitis patients with signs of clinical inflammation with no clinical attachment loss. * chronic periodontitis patients having probing depth of ≥3 mm and clinical attachment level ≥ 1 mm. * the control group: healthy subjects who attend the restorative dental clinic and had clinically healthy gingiva. exclusion criteria: * patients with any systemic diseases