Kornimate/medical-research-clean huggingface dataset:
impact of adding tens to conventional physical therapy exercise on pain relief among patients with pudendal neuralgia.

Conditions: Pudendal Neuralgia

Summary: fifty two male participants, 30-50 years old, suffering from chronic pudendal neuralgia were randomly assigned either into experimental group (26 patients) received tens plus the traditional physical therapy program( including range of motion exercise, stretching exercise of obturator internus muscle, clam shell exercise, relaxation exercise and underwater exercise) 3 sessions per week for 8 successive weeks, or control group (26 patients) received only the traditional physical therapy exercise for the same period of time. intensity of pain by verbal rating scale (vrs) as well as serum cortisol level (scl)and etodolac level intake are measured pre and post treatment.


Eligibility criteria:
inclusion criteria: * male with ages ranged from 30 to 50 years. * suffering from pudendal neuralgia and its intractable perineal pain that persists for a minimum one month beyond the acute onset. * pelvic pain with sitting that relived by standing or toilet sitting. * anal pain, dyspareunia and genital pain exclusion criteria: * those who had history of skin malignancy. * diabetic, * sensory disorders, * circulatory insufficiency * acute infection of the treatment area, * renal failure
utb-vbn-ebus with or without fluoroscopy for the diagnosis of ppls

Conditions: Lung Cancer

Summary: the purpose of this study is to evaluate the feasibility,efficacy and safety of ultrathin bronchoscopy(utb) combined with virtual bronchoscopic navigation(vbn) and endobronchial ultrasound(ebus) for the diagnosis of peripheral pulmonary lesions (ppls) without radiographic fluoroscopy.

the investigators evaluate feasibility,efficacy and safety of utb combined with vbn and ebus for the diagnosis of ppls without radiographic fluoroscopy.bronchoscopes with a 3.0-mm distal end diameter and a 1.7-mm working channel diameter are used (bf-y0058;olympus).the final diagnoses are established by pathological evidence from biopsy or cytology specimen including bronchoscopy or other procedures,microbiological analysis and clinical follow-up.the study is designed as a single center prospective randomized controlled trial.the participating center is department of endoscopy, shanghai chest hospital, shanghai jiao tong university, china.subjects will be randomized (1:1) to utb-vbn-ebus-x-ray group and utb-vbn-ebus group based on a randomization schedule.the study is expected to enroll 200 patients with 100 patients of each group.

Eligibility criteria:
inclusion criteria: 1. patients with peripheral pulmonary lesions suspected to be cancer that need pathologically confirmed; 2. presence of bronchus leading to or adjacent to the lesion from ct scan. exclusion criteria: 1. pure ground glass opacity (ggo) lesions; 2. refusal of participation; 3. severe cardiopulmonary dysfunction and other indications that can't receive bronchoscopy; 4. presence of concomitant endobronchial lesion during the brochoscopy procerdure.

Keywords: endobronchial ultrasonography peripheral pulmonary lesions ultrathin bronchoscopy
prediction of the risk of biochemical relapse after radical prostatectomy for prostate cancer using radomics on pre-therapeutic mri

Conditions: Prostatic Adenocarcinoma

Summary: with 50% of post-operative biochemical failure, efficient predictive models are needed to guide post-operative management. radiomic features are quantitative features extracted from medical imaging, supposed to be correlated with tumor heterogeneity. we aim to build and test three predictive models (clinical, radiomic and combined models).


Eligibility criteria:
inclusion criteria: * age \> 18yo * patients underwent radical prostatectomy * high-risk prostate cancers: at least 1 criteria (pt3a/pt3b/pt4, r1, gleason score \> 7) exclusion criteria: * no available pre-operative mri * no analyzable pre-operative mri * proof of lymph-node involvement (cn1/2 or pn1/2) * post-operative psa \> 0.04ng/ml
effect of aerobic training versus myofacial release on claudication among prepherail arterail insuffiecency patients

Conditions: Peripheral Arterial Disease

Summary: this study is trying to answer the following research question: "are there any differences between effects of aerobic training and myofascial release on claudication among peripheral arterial insuffiency patients?

peripheral arterial disease is a systemic disorder and for the most part progressive. the condition is associated with life and limb-threatening complications. symptoms of pad range from intermittent claudication-defined as fatigue or discomfort in calf, buttock, or thigh muscles on exertion that is relieved by rest-to critical limb ischemia-defined as distal leg pain at rest with or without ischemic ulcers despite many advances in endovascular surgery, amputations of digits and limbs are not uncommon. thus, the present-day approach is to prevent the disorder in the first place. there are many evidences that support changes in lifestyle can significantly decrease the rate of progression of the disease and improve the quality of life in addition to aerobic training exercise and manual therapy .

Eligibility criteria:
inclusion criteria:the patients had been met the following criteria to be involved in this study: 1. patients from both sexes who were medically diagnosed as peripheral arterial insufficiency with type ii claudication at single lower limb 2- peripheral arterial insufficiency patients, who have abi inbetween0.90-0.50 1. age was ranged from 45 -55years. 2. patients who have intermittent claudicating pain during activities not at rest. 3. bmi between 25-29.9 kg - exclusion criteria: 1. patients who was not willing to participate in the study. 2. patients who have severe foot ulcer, and who were diagnosed as peripheral arterial insufficiency grade iii, iv. 3. patients who have the abi is less than 0.50 4. patients who have past history of (unstable cardiovascular diseases, marked dyspnea on exertion or with chronic obstructive pulmonary diseases (copd), liver and kidney diseases). -
temperature and mortality

Conditions: Cardiovascular Diseases

Summary: the investigators evaluated the spatial association between, cardiovascular diseases (cvd) and stroke mortality rate with average ambient temperature (ta) , and then used this relationship to model future temporal trends in mortality from cvd and stroke till the end of century (2099) using different warming scenarios across the mainland usa.

the investigators used data on mortality rate (per 100,000 individuals) for cvd and stroke (between 2011 and 2013, age\>35years) from the publicly available centers for disease prevention and control (cdc) web site (www.cdc.gov). cvd mortality was defined as the number of deaths per 100,000 personyears due to circulatory causes (international statistical classification of diseases, tenth revision, codes i00-i99).oak ridge national laboratory was the source of the ambient temperature data (http://www.daac.ornl.gov: files b01, b02 and c07).the investigators obtained data on prevalence of htn (htn was defined as systolic blood pressure (bp) of at least 140 mm hg, self-reported use of antihypertensive treatment, or both) from county health rankings and roadmaps organisation (www.countyhealthrankings.org), which were estimated based on national health and nutrition examination survey in five two-year waves from 1999-2008 including 26,349 adults aged 30 years and older and from the behavioral risk factor surveillance system (brfss) from 1997-2009 including 1,283,722 adults aged 30 years and older.

Eligibility criteria:
inclusion criteria: 1. age\>35 years exclusion criteria: none
using hypnosis and virtual reality during pre and postoperative cardiovascular surgery.

Conditions: Thoracic Surgery; Pain, Postoperative; Anxiety; Fatigue

Summary: nowadays, the use of cognitive behavioral therapies has become quite common in the clinical care. different non-pharmacological techniques, including hypnosis and virtual reality are currently used as complementary tools in the treatment of acute and chronic pain (pourmand et al., 2017; vanhaudenhuyse et al., 2009). a new technique called 'virtual reality hypnosis' (vrh) (patterson et al., 2004), which encompasses a combination of both tools, is regularly used although its actual function remains unknown to this date. with the goal to improve our understanding of vrh combination effects, it is necessary to elaborate randomized and controlled research studies in order to understand their actual function in individual's perception. 100 patients who are undergoing a cardiovascular surgery at the liège university hospital will be randomly assigned to four conditions (control, hypnosis, vr and vrh). each participant will receive two sessions of one of the techniques: one the day before the surgery and one other session the day after, in intensive care units. physiological parameters will be taken and participants will fill in a questionnaire which evaluates their level of perceived immersion, their level of anxiety, fatigue, pain and relaxation. a short interview will also be conducted to give participants the opportunity to openly describe their experience. this study will help to expand the knowledge regarding the influence of these techniques on patient's cognition, perception and sensation .

primary outcome (anxiety) and secondary outcomes (pain, fatigue, relaxation and physiological parameters) will be investigated at four measurement times: the day before the surgery (day -1) before the intervention (t0: baseline) and after the intervention (t1); the day after the surgery (day+1) before the intervention (t2) and after (t3).

Eligibility criteria:
inclusion criteria: * adults undergoing cardiac surgery * who have given consent for their participation. exclusion criteria: * psychiatric antecedents * claustrophobia * acrophobia, * heavy hearing * visual impairment * infectious cases (example: conjunctivitis)

Keywords: virtual reality hypnosis intensive care units cardiac surgery anxiety pain cognition and perception recovery
effectiveness of mysmile app for improving the oral health of secondary school children:

Conditions: Oral Disease; Gingival Diseases

Summary: the goal of this cluster-randomised control trial is to assess the effectiveness of the mysmile app for improving oral health in secondary school children. the main questions it aims to answer are: 1. will the mysmile app be more effective in improving secondary school children's dental plaque and gingival health over and above the existing school dental service (sds)? 2. will the mysmile app be more effective in improving secondary school children's oral health knowledge, attitudes, and behaviours over and above the existing sds? 3. is the mysmile app easy to use by secondary school children? 4. is the mysmile app acceptable to use from the perspective of secondary school children? participants in the intervention group will receive the sds and mysmile app. the control group will receive sds only. therefore the researcher will compare between the intervention and control group in terms of dental plaque, gingival health, oral health knowledge, oral health attitudes and oral health behaviours.

the selection of schools into the study will involve three (3) sampling levels. at the first level, acknowledging the division of secondary schools in the district into urban and rural, one matched-pair will be randomly selected from urban area, and another matched pair will be randomly selected from rural area. at the second level, randomisation of the school is carried out. the 2 schools in each of the matched-pair will be randomly allocated to intervention and control group. at the third level, six (6) classrooms from moderate academic performance level will be selected (2 classrooms from form 3, form 4, and form 5, respectively). students who fulfil the inclusion criteria will be invited to participate in the study. the randomisation sequence will be carried out by the statistician at the faculty of dentistry, universiti malaya

Eligibility criteria:
1. inclusion criteria for school * government-funded secondary school * received sds from the mobile dental squad/school dental clinic at least once a year. * high-risk schools with all indicators not meeting the district's benchmark. 2. inclusion criteria for the participants: * secondary school children aged 15-17 years old. * medium to high dental plaque level - plaque score more than 50% * healthy with no chronic medical history and physical disabilities * understand the english language. * own a smartphone// have access to an android-based smartphone

Keywords: mobile apps prevention oral health promotion schoolchildren
assessing hydration status with a wearable bioimpedance sensor in elderly individuals

Conditions: Dehydration

Summary: this is a single-arm prospective study, investigating the feasibility, usability, and safety of a wearable bioimpedance sensor in elderly individuals. the sensor is applied on the upper back of the subject, and will be replaced once weekly. the study will include four phases, each interspersed by an interim analysis. each phase will have a duration of four weeks.


Eligibility criteria:
inclusion criteria: * age ≥ 60 years exclusion criteria: * known allergies or skin sensitivities to electrode hydrogel and/or acrylic-based adhesives * non-intact skin such as skin breakdown where the device is to be placed (upper back) * implantable pulse generators such as pacemakers and defibrillators * any medical or psychiatric condition, which in the opinion of the investigator precludes participation
avl200 iol for treatment of cataract and presbyopia

Conditions: Cataract

Summary: this study is to evaluate the performance of the avl200 iol in terms of visual function improvement over a range of focal points. participants meeting eligibility criteria will undergo cataract surgery with implantation of the avl200 intraocular lens (iol), then be followed through 1 year postoperatively. postoperative assessments include safety and visual function.


Eligibility criteria:
inclusion criteria: * visually significant cataract * best corrected distance visual acuity between 20/40 and 20/200 * potential distance visual acuity of 20/32 or better * corneal astigmatism ≤ 1.5 diopters exclusion criteria: * use of medication that could affect accommodation * previous corneal surgery or significant corneal abnormalities * ocular pathology or degenerative disorder having potential to impair visual acuity * pupil abnormality * intraoperative cataract surgery complications that could affect iol implantation or positioning
evaluation of remote patient monitoring.

Conditions: Congestive Heart Failure; Chronic Obstructive Pulmonary Disease

Summary: nottingham primary care trust has launched telemonitoring to support: independent living and self-management ability of people with congestive heart failure (chf), chronic obstructive pulmonary disease (copd) and co-morbidities; and reduce the health care utilisation associated with these patients, including the number of hospitalisations, gp visits and community matron and specialist community nurse home visits. the multidisciplinary assessment of technology centre for healthcare (match) will evaluate the technology and its impact of this telemonitoring system on quality of care (i.e. process measures), patient outcomes and direct healthcare costs from an nhs perspective.

the study is designed to evaluate the impact of home-based monitoring to support community based nursing services and care matrons in the management of patients with chf and copd and co-morbidities. the main issue is to design a study that will determine the impact of the use of the technology independent of other factors. a randomised controlled trial has been chosen in which equal numbers of participants with and without home-based monitoring will be followed over the study to determine differences in utilisation of healthcare services including number of hospitalisations, length of stay in hospital, gp visits and community matron and specialist community nurse home visits. the ethical issue is how to determine those that will receive home-based monitoring and those that will be denied. the study requires that participants are matched for severity of their condition in each arm and this could deny some from the potential benefits of monitoring. however, as only a limited number of home-based monitors are available and all participants will continue to receive normal health care services, we believe that those denied monitoring will not receive care that is different to patients not in the study and the ethical issues are acceptable.

Eligibility criteria:
inclusion criteria: * participants selected will be those: diagnosed with chf, copd or co-morbidities and referred to the community management service by its selection procedure for severity of the condition; are considered eligible for home-based telemonitoring; consent to receiving telemonitoring; have an active phone connection; are able to read and speak english (language of the equipment); are capable and willing to use the home monitoring device. exclusion criteria: * patients are considered ineligible: if they have psychological or psychiatric disorders; if they have a cognitive deficiency that makes them unable to participate in their self-treatment; if they have a visual or motor deficiency that renders them incapable of using the telemonitoring device (unless a spouse or an informal caregiver is able to help); if they are currently scheduled for a hospital admission; if their life expectancy is shorter than 2 years; or if they already participate in another study.

Keywords: telehealth telemonitor telemedicine co-morbidities
thermotape high-adhesion medical tape comparison study

Conditions: Skin Injury

Summary: this objective of this study is to compare the safety and performance of thermotape compared to tegaderm™ tape and kind™ tape over the course of 24 hours.


Eligibility criteria:
inclusion criteria: * participants should be between 18 to 25 years of age. exclusion criteria: * participants with history of eczema or medical related skin injuries (marsi), allergic to adhesives, and/or have a wound or rash on their skin will be excluded.
serum adiponectin in chinese population and its correlation to cardiovascular and cerebrovascular diseases

Conditions: Myocardial Infarction; Cerebral Infarction

Summary: adiponectin (ad) is an abundant protein in human body, and reports have shown that it act as a novel risk factor for brain and heart ischemia injury. this 5 years follow-up study will focus on serum adiponectin concentration, activity and isoforms in chinese population and its correlation to these diseases.

adiponectin (ad) is an abundant protein hormone regulatory of numerous metabolic processes, anti-inflammatory, vascular protective, and anti-ischemic properties. since its 1995 discovery, ad has garnered considerable attention for its role in diabetic and cardiovascular pathology. clinical observations have demonstrated the association of hypoadiponectinemia in patients with obesity, cardiovascular disease, and insulin resistance. there is growing evidence supporting ad can act as a novel risk factor for cardiovascular and cerebrovascular injury. this 5 years follow-up study will focus on serum adiponectin concentration, activity and isoforms in chinese population and its correlation to cardiovascular and cerebrovascular diseases.

Eligibility criteria:
inclusion criteria: * available for 5 years of follow-up study exclusion criteria: * death caused other than cardiovascular and cerebralvascular diseases till the study ends * floating population * pregnancy, lactation, or child bearing women * tumor * active hepatic disease or hepatic dysfunction, or ast/alt \> 1.5unl * severe renal dysfunction(scr \> 3 mg/dl or 264μmol/l) * patients with any condition which, in the investigator's judgment, might increase the risk to the subject for any adverse event or abnormal laboratory finding

Keywords: adiponectin cardiovascular diseases cerebrovascular diseases
efficacy and safety of symptom improvement by digital therapeutics to manage hypotension symptoms

Conditions: Hypotension

Summary: this clinical trial is an exploratory study aimed at assessing the efficacy and safety of a digital therapeutic for managing symptoms of hypotension, with the goal of providing evidence for the design of future confirmatory clinical research.


Eligibility criteria:
inclusion criteria: 1. adults aged 19 and older with symptoms suspected to be related to dizziness due to hypotension within the past year. 2. individuals who are able to walk and can participate in the study using a smartphone, or for whom cooperation from a guardian is available. exclusion criteria: 1. individuals diagnosed with causes of dizziness other than hypotension, such as benign paroxysmal positional vertigo or stroke, within the past year. 2. severe anemia (history of hb \< 8.0 g/dl within the last 3 months). 3. individuals unable to use a smartphone (android phone) or smartwatch. 4. individuals with a life expectancy of less than 1 year due to diseases such as malignant tumors. 5. individuals diagnosed with severe heart valve disease or severe heart failure with lvef \< 35% (based on the most recent examination). 6. recent rapid and unintended weight loss (5% or more, or 5 kg or more, within the last 6 months).
a safety study of the latanoprost punctal plug delivery system (l-ppds) in subjects with ocular hypertension or open angle glaucoma

Conditions: Glaucoma; Ocular Hypertension

Summary: the purpose of this study is to determine if the punctal plug delivery system is safe and effective in controlling intraocular pressure in patients with ocular hypertension or open-angle glaucoma.


Eligibility criteria:
inclusion criteria: * over 18 yrs with ocular hypertension or open-angle glaucoma * subjects who have a best-corrected visual acuity of 20/100 or better. exclusion criteria: * subjects who wear contact lenses. * uncontrolled medical conditions * subjects requiring chronic topical artificial tears, lubricants, and/or requiring any other chronic topical medications. * subjects who have a history of chronic or recurrent inflammatory eye disease.