Kornimate/medical-research-clean huggingface dataset:
the dissection of lymph node posterior to right recurrent laryngeal nerve for papillary thyroid carcinoma

Conditions: Lymph Node Metastases

Summary: this study was completed in two stages. in the first stage, 2000 participants were enrolled according to the criteria. following the principle of informed consent and voluntary consent of patients, the standard operation was "right or bilateral thyroidectomy + isthmus resection + right area vi lymph node dissection + left area vi lymph node dissection + lateral neck lymph node dissection". the age of participants, the size of right thyroid tumors, the invasion of the capsule and the number of lateral neck lymph node metastasis were counted to validate and improve the predictive model of lymph node posterior to the right recurrent laryngeal nerve in papillary thyroid cancer (y=-0.029×age+0.771×tumor size+0.660×capsular invasion+1.331×right lateral lymph node metastasis-1.687, y ≥0.16 means right recurrent laryngeal nerve posterior lymph node metastasis). in the second stage, 2000 participants assessed by the model without posterior right recurrent laryngeal nerve metastasis were randomly divided into experimental group and control group according to the principle of informed consent and voluntary. the right recurrent laryngeal nerve posterior lymph nodes were not dissected in experimental group, while the right recurrent laryngeal nerve posterior lymph nodes were routinely dissected in control group. through long-term follow-up and comparison of rfs and os between the two groups, the investigators can scientifically evaluate the effectiveness of the "prediction model of lymph node posterior to right recurrent laryngeal nerve metastasis in papillary thyroid carcinoma", and seek evidence for accurate treatment of lymph node posterior to the right recurrent laryngeal nerve in thyroid papillary carcinoma.


Eligibility criteria:
inclusion criteria: * phase i: 1. aged from 18 years old to 80 years old; 2. the primary treatment of patients with right or bilateral ptc; 3. patients will voluntarily enter the study after informed consent. phase ii: 1. aged from 18 years old to 80 years old; 2. the primary treatment of patients with right or bilateral ptc predicted to have no ln-prrln metastasis by the "prediction model of ln-prrln"; 3. patients will voluntarily enter the study after informed consent. exclusion criteria: 1. patients refused to participate in the study; 2. non first operation patients; 3. other malignant tumor history; 4. distant metastasis; 5. history of neck trauma.
optimization of vim targeting in essential tremor surgery

Conditions: Essential Tremor

Summary: deep brain stimulation (dbs) for essential tremor is based on the intermedius ventralis nucleus of the thalamus (vim) stimulation. this structure is however very difficult to target, as it remains invisible on imaging. the current procedure based on awake surgery with clinical and electrophysiological testings has several limitations that lead us to develop a probabilistic model to locate precisely the target. this study aims to show that asleep dbs surgery based on this new targeting method leads to at least the same clinical results than the classical procedure.

the intermedius ventralis nucleus of the thalamus (vim), which represents the target for deep brain stimulation (dbs) in essential tremor, still remains invisible on 1,5 tesla mri (the only magnetic field available for stereotactic surgery). the target coordinates currently used are based on stereotactic atlases or mean coordinates from retrospective series. they are so imprecise that intra-operative clinical testing and micro-electrode recordings are mandatory to locate the exact position of the vim. this procedure is long lasting, requires that the patient is awake, and increases the risk of intracerebral haemorrhage and nosocomial infections. furthermore, some patients are not improved despite a dbs lead implanted in the electrophysiologically and clinically defined target. to overcome these limitations, investigators developed a probabilistic model based on data extracted from imaging of patients with particularly good outcomes after dbs surgery. this machine-learning model allows calculating to coordinates of the vim according to the position of radio-anatomical landmarks with a mean precision of 1,65mm. the aim of this study is to validate this new targeting method on a prospective cohort of patients. dbs surgery will be performed under general anaesthesia, without intra-operative clinical and electrophysiological testing, with a surgical robot and under ct-scan guidance (o-arm ©). neurostimulation device programming will be performed as usual. patients' tremor and quality of life will be evaluated pre and post-operatively at 3 months, according to the fahn-tolosa-marin (ftm) scale and with an accelerometry recording (for tremor) and with the mpdq-39 scale for quality of life. surgical complications and side effects related to neurostimulation will be gathered all along the follow-up.

Eligibility criteria:
inclusion criteria: * severe essential tremor despite the optimal medical management * age between 18 and 75 years * normal mri scan * mattis dementia rating scale (mdrs) score ≥ 130 * affiliation to the social security * signed informed consent exclusion criteria: * depression (beck depression inventory scale \> 20) * contra-indication to surgery or general anesthesia * cerebral atrophy on mri scan * pregnant or breastfeeding women

Keywords: essential tremor deep brain stimulation ventro-intermediate nucleus of the thalamus targeting asleep surgery
autism, emotional processing, and the amygdala

Conditions: Autism Spectrum Disorder

Summary: empathy imbalance hypothesis suggests that individuals with autism spectrum disorder (asd) should have a deficit of cognitive empathy and a surfeit of emotional empathy. considering that inconsistent amygdala reactivity to emotional faces might be ascribed to aberrant attention in asd, the investigators hypothesized to investigate if there would be an imbalance between conscious and nonconscious emotional processing. this fmri study recruited 26 youths and young adults with autism spectrum disorder and 25 matched controls, and measured their amygdala reactivity and functional connectivity in response to conscious and nonconscious (backward masked) perception of threatening faces. keywords: autism spectrum disorder; amygdala reactivity; emotional processing; fmri


Eligibility criteria:
inclusion criteria: * clinical diagnosis of severity of autism-spectrum disorders * iq \> 75 exclusion criteria: * neurological abnormalities, * a history of epilepsy or seizures, head trauma a * iq \<75
effect of a mixture of new probiotic strains in preterm infants

Conditions: Premature Infant

Summary: an interventional, randomized, double-blind, placebo-controlled study will be conducted to investigate the effect of a new probiotic strain lactobacillus ps11603 \& bifidobacterium ps10402 in premature infants from 28 weeks + 0 days to 30 weeks + 6 days of gestation. the study duration will be 2 months, which includes 8 weeks product administration. participants will be randomized assigned to one of the two study groups: the control group with placebo consumption and a probiotic consumption group.

an interventional, randomized, double-blind, placebo-controlled study will be conducted to investigate the effect of a new probiotic strains lactobacillus ps11603 \& bifidobacterium ps10402 in 30 premature infants born within 28 weeks + 0 days to 30 weeks + 6 days of gestation. the duration of participation in the study is estimated to be 40-60 days. participants will be randomized assigned to one of the two arms of the study: the control group, with placebo consumption, and a probiotic consumption group. the aim of the study will be investigate the effect of the probiotics strains in the colonization of the intestinal tract of preterm babies.

Eligibility criteria:
inclusion criteria: * preterm infants born between week 28 + 0 days and week 30 + 6 days of gestation. * written informed consent signed by the parent or legal guardian. * tolerate enteral feeding, at least 10ml / kg / day. * postnatal age ≤ 5 days exclusion criteria: * child with malformations * with short bowel syndrome or any surgery in the gastrointestinal tract * with defect in the intestinal epithelial barrier
l-carnitine to treat fatigue associated with crohn's disease

Conditions: Crohn's Disease; Fatigue

Summary: this is a randomized, double-blind, placebo-controlled study, comparing the effect of l-carnitine vs placebo on fatigue among crohn's disease patients. the specific aim of this study is to determine if treatment with l-carnitine is more effective than placebo at decreasing fatigue severity scores, while accounting for disease activity and concomitant anemia, depression/anxiety and poor sleep quality.

a total of 100 patients will be recruited, in order to be able ensure to detect a significant difference in fatigue between the treatment and control groups.

Eligibility criteria:
inclusion criteria: * patients will have had previously macro- and microscopically verified crohn's disease, as defined by traditional clinical and endoscopic standards. * to be included, patients need to have disease which is either in remission or is mild to moderate in severity, as defined by the harvey-bradshaw index score (hbi\<16). * in addition, patients will need to answer "yes" to the screening study entry question ("is fatigue a signficant problem for you currently?"). exclusion criteria: * exclusion criteria will include: * age \ 70 years * pregnancy or delivery within 6 months * malignancy diagnosed within 1 year * oral/intravenous steroid treatment within 6 months * any surgery within 6 months * presence of a stoma or ileo-anal j-pouch anastomosis * concurrent hepatitis b or c infection * cirrhosis * renal insufficiency (crcl\<60) and history of seizure disorder or hypothyrodism. * prior to study enrollment * women of child-bearing age will need to undergo pregnancy testing.

Keywords: crohn's disease carnitine
descriptive analysis of dual-energy computed tomography exams of adult patients with gout

Conditions: Gout

Summary: the main objective is to describe urate deposits (especially in terms of distribution and volume) in soft tissues and bone, and joint erosions and destruction, in adult patients with gout.

gout is the result of hyperuricemia, itself a consequence of a disorder of purine metabolism. this hypuricemia can lead to the deposition of sodium urate crystals in the soft tissues. it is the deposition of sodium urate crystals in and near the joints that causes an intense local inflammatory reaction with episodes of acute joint pain, swelling and functional disability. in the long term, uratic concretions in the soft tissues (tophus) occur, the joints are destroyed (uratic arthropathies), the kidneys also (gouty nephropathy). dual-energy ct (computed tomography) is a relatively recent technique that allows the identification of certain materials through the analysis of the difference in attenuation of the material exposed to two different x-ray spectra. this technique identifies the crystalline component of tophus.

Eligibility criteria:
inclusion criteria: * age greater than or equal to 18 years old; * patient with a gout according to acr (american college of rheumatology) criteria; * affiliated with a social security scheme. * dual-energy scanner examinations stored in the pacs at lariboisière hospital exclusion criteria: * pregnant or breastfeeding woman.
rescue stenting and intravenous thrombolysis in patients with large vessel ischemic stroke

Conditions: Large Vessel Occlusion; Stroke Acute; Thrombolysis; Rescue Stenting

Summary: intravenous thrombolysis (ivt) and mechanical thrombectomy (mt) are the standard of care for treating selected patients with acute large-vessel occlusion stroke (lvos). successful revascularization is strongly correlated with favorable outcomes. nevertheless, recanalization failure with stent retrieval and contact aspiration has been observed in up to 29% of patients. if primary thrombectomy fails to achieve recanalization, rescue stenting (rs) has proven to be a feasible rescue therapy. currently, approved evidence-based alternatives for lvos patients who have failed mt are lacking, but permanent stenting is suggested as a rescue treatment in expert consensus statements. dual antiplatelet therapy (dapt), typically consisting of clopidogrel and aspirin, is recommended after stent implantation to reduce the risk of stent thrombosis; however, these medications are not suitable in the acute setting, and optimal platelet inhibition strategies remain unclear. glycoprotein (gp) iib/iiia receptor inhibitors have intravenous administration, a rapid onset of action, and their effects subside within a few hours after discontinuation. for these reasons, an increasing number of studies have investigated their use in conjunction with primary stenting for acute stroke. currently, there is no evidence supporting the superiority of any particular antithrombotic strategy, so decisions are guided by clinical judgment. an additional challenge for clinicians arises when ivt is combined with stenting. stroke guidelines recommend starting antiplatelets 24 hours after ivt and the risk associated with antithrombotic therapy within the first 24 hours after ivt remains uncertain. this is multicenter, prospective, observational study of patients with lvos undergoing mechanical thrombectomy and rescue stenting. the aim of this study is to evaluate real-world antithrombotic strategies in emergency stenting, particularly in patients treated with ivt, and to assess the safety of emergent stenting following intravenous thrombolysis.


Eligibility criteria:
inclusion criteria: * patients with large vessel occlusion strokes undergoing thrombectomy and rescue stenting within 24 hours of stroke onset * patients ≥ 18 years of age exclusion criteria: * patients \< 18 years * refusal to give informed consent

Keywords: rescue stenting thrombolysis
study inflammation during a 100 miles

Conditions: Inflammatory Response

Summary: to study per and post effort variations of inflammatory biological markers during a 100 miles


Eligibility criteria:
inclusion criteria: * adults (age\>18years) * completion of an ultra endurance race (50 miles) during the 2 years before exclusion criteria: * female * age\<18years

Keywords: sport exercise ultra endurance
telemedical support in prehospital emergency care of acute coronary syndrome

Conditions: Acute Coronary Syndrome

Summary: the aim of the study is to investigate the quality of prehospital emergency care in acute coronary syndromes, when paramedics are supported telemedically by an ems physician.

six ambulances from five different emergency medical service (ems) districts are equipped with a portable telemedicine system. in cases of suspected acute coronary syndrome (including stemi), the paramedics can use this system to contact a so called "tele-ems physician" after consent of the patient is obtained. the tele-ems physician has an audio-connection to the ems team and receives vital parameters (e.g., ecg, pulse oximetry, non-invasive blood pressure) in real-time. also 12-lead-ecgs can transmitted to the tele-ems physician. the transmission of still pictures - taken with a smartphone - and video streaming from the inside of the ambulance can be carried out, if meaningful. the tele-ems physician supports the ems team in obtaining all relevant medical history, ecg diagnosis, general diagnosis and can delegate the application of medications. this can be carried out to bridge the time to the arrival of an ems physician or in less severe cases without an ems physician on-scene. the quality of prehospital care and the possible influences on the initial inhospital phase should be investigated and compared with regular ems.

Eligibility criteria:
inclusion criteria: * suspected acute coronary syndrome * verbal consent for teleconsultation obtained or patient is not able to consent due to the severity of the emergency exclusion criteria: * patient refuses consent to teleconsultation * no suspected acute coronary syndrome

Keywords: acute coronary syndrome telemedicine teleconsultation emergency medical service
effect of high dose naloxone on secondary hyperalgesia

Conditions: Hyperalgesia; Pain; Naloxone; Opioid Antagonist

Summary: recent studies have focused on the role of endogenous opioids on central sensitization. central sensitization is known to be impaired or altered in chronic pain conditions, as fibromyalgia or chronic tension headache. animal studies have shown reinstatement of mechanical hypersensitivity following naloxone administration after resolution of an injury. this suggests latent sensitization. in the present study, investigators hypothesize that naloxone (2 mg/kg) can reinstate secondary hyperalgesia 168 hours after a first-degree burn-injury. investigators aim therefore to show that latent sensitization is present in humans and is modulated by endogenous opioids.


Eligibility criteria:
inclusion criteria: * healthy man * written informed consent * asa 1-2 * bmi 18 \< bmi \< 30 * normal ultrasound examination of the heart * normal ecg * urin sample without traces of opioids exclusion criteria: * volunteers, who do not understand the danish language * participation in another experimental trial in the previous 60 days * nerve damage or skin lesions in the assessment areas * neurological or psychiatric condition * use of psycho-active drugs * abuse of alcohol or drugs * chronic pain * regular use of pain-killers (\> 1 a week) * allergy against morphine or other opioids (including naloxone) * use of prescription drugs 1 week prior to the trial * use of over-the-counter medication 48 hours prior to the trial * urin sample with traces of opioids * volunteer is not suitable for the trial according to the investigator's consideration

Keywords: secondary hyperalgesia allodynia mechanical pain threshold naloxone endogenous opioids pain
enhancing antiepileptic drug adherence

Conditions: Epilepsy

Summary: more than half of patients with epilepsy achieve full control of their seizures with antiepileptic drugs (aeds).the study is aimed to investigate effectiveness of an educational intervention in improving medication adherence in patients with epilepsy.


Eligibility criteria:
inclusion criteria: * diagnosis of epilepsy according to the international league against epilepsy criteria * age equal or higher than 18 years * independence in daily living activities * absence of major cognitive impairment or active psychiatric disorders exclusion criteria: * presence of a rapidly progressing neurological or medical disorder * patients not receiving anti-epileptic drugs * a history of significant substance abuse within the past year * a diagnosis of mental retardation

Keywords: epilepsy
the effect of alfa-adrenergic receptor blockade on insulin-stimulated forearm glucose uptake and metabolism in chronic heart failure

Conditions: Heart Failure, Congestive

Summary: the activity of the sympathetic nervous system seems to influence the uptake (and handling) of glucose by the skeletal muscle of the forearm. conditions in which sympathetic activity is increased seem to inhibit/reduce forearm glucose uptake. inversely a decrease in sympathetic activity seems to increase glucose uptake. this study analyzes the effect of alfa-adrenergic receptor blockade (counteracting sympathetic influence) on insulin-stimulated forearm glucose uptake in patients with increased sympathetic activity (patients with chronic heart failure).


Eligibility criteria:
inclusion criteria: * heart failure of at least new york heart association (nyha) class ii * left ventricular ejection fraction (lvef) \<= 40% * age 18-75 years exclusion criteria: * alfa-blockers, or beta-blockers with alfa-blocking activity (carvedilol) * tricyclic antidepressants * warfarin derivatives (acetylic salicylic acid and clopidogrel are allowed) * hospitalisation in 6 weeks prior to the study * any change in medication in 6 weeks prior to the study * unstable angina * orthopnoea * known chronic disease of the autonomic nervous system * diabetes mellitus * oedema of the lower extremities, complicating the insertion of a venous catheter in a vein on the foot
acute effects of low and high-speed resistance training on blood pressure in older adults: a crossover study

Conditions: Blood Pressure; Frailty

Summary: the first study was a randomized crossover trial that compared the acute effects of high speed resistance exercise (hsre) and traditional resistance exercise (tre) on blood pressure parameters in a sample of frail older adults. participants performed three experimental sessions (i.e., hsre, tre, and a control session \[cs\]) in a random order and separated from one another by seven days (standard deviation \[±\] 1 day). food consumption was maintained constant during 48 h prior to the exercise session and a standard breakfast was offered 60-90 min before the beginning of the experimental sessions. the pharmacological therapy was kept constant during the whole study, and participants took their anti-hypertensive medication at the same time in all experimental days as prescribed by their physician.


Eligibility criteria:
inclusion criteria: - aged ≥60 years; frail according to fried's criteria (fried et al., 2009); possessed sufficient physical and cognitive abilities to perform all exercises required by the protocol; had a physician authorization to participate of exercise programs. exclusion criteria: participation in a structured physical exercise training program in the past six months; prescription of hormone replacement therapy and/or psychotropic drugs; presence of any acute cardiovascular event (e.g., myocardial infarction) or complication in the past six months.