Kornimate/medical-research-clean huggingface dataset:
vaginal electrical stimulation versus neuromodulation

Conditions: Refractory Overactive Bladder

Summary: this prospective study compares quality of life measures of patients with refractory overactive bladder, between two modes of neuromodulation: vaginal electrical stimulation (group a) and sacral nerve stimulation (group b). the specific aims are: 1. to characterize patient symptom bother score, quality of life, and body image scores in patients obtaining sacral nerve stimulation, as compared to vaginal electrical stimulation. - hypothesis 1: both modes of neuromodulation will impact patients' scores in quality of life, patient symptoms, and body image questionnaires.

all participants will have a standardized intake history which will include age, weight, history of prior treatment for incontinence, medication list, obstetric and gynecologic history, medical history, and surgical history, as well as a complete review of systems. the physical examination will include vital signs (including bmi), genitourinary exam, including pelvic organ prolapse quantification (popq), and neurologic exam. all patients will undergo spontaneous uroflowmetry, urine dipstick from catheterized specimen, multichannel urodynamics, and 3-day voiding diary. measurement of post-void residual will also be obtained. completion of the udi-69, king's health questionnaire10, and the modified body image perception scale (mbis) will also be part of the initial visit 11,12. all participants taking anticholinergics will undergo a 2 week flush-out period prior to the intake assessment. after the intake assessment, the provider will determine which treatment option is appropriate to the participant, and they will then be assigned to one of the two treatment arms: group a will use vaginal electrical stimulation using the empi intravaginal stimulation unit minnova (empi, st. paul, mn, usa) and participants in group b will receive sacral neuromodulation using interstim (medtronic, minneapolis, mn, usa).

Eligibility criteria:
inclusion criteria: * diagnosis of refractory oab (+/- uui)\* * female gender * eligible for both treatment interventions * available for 8 weeks of follow-up * able to complete study assessments * must discontinue anticholinergics within 2 weeks of intervention exclusion criteria: * age \< 21 * pregnancy * stage 3 or 4 pelvic organ prolapse * current use of anticholinergics * urinary tract infection * undergoing concurrent treatment for pelvic organ prolapse * unstable or serious cardiac arrhythmia * implanted pacemaker * postvoid residual \> 100ml * unstable seizure disorder * dementia or inability to follow instructions
hormones inflammation and thrombosis

Conditions: Acute Coronary Syndrome; Thrombosis

Summary: the investigators are attempting to determine if the response to aspirin in women is related to the level of estrogen and progesterone that a woman has.

thrombosis plays a significant role in both acute coronary syndromes (acs) and early saphenous vein graft (svg) failure. women with coronary heart disease have higher levels of the inflammatory mediator thromboxane, which is produced by platelets, monocytes, macrophages and the endothelium. data show that higher levels of urinary thromboxane (utxb2) are associated with svg failure 6 months after coronary artery bypass graft (cabg). women in the study cohort had higher levels of utxb2 and higher odds of graft failure when compared to men. the elevated urinary thromboxane seen in the women in our study cohort may represent a marker and/or an etiology of thrombosis. are the levels of utxb2 higher in women due to hormonal differences? in a prior pilot study we investigated whether hormonal levels are associated with changes in urinary thromboxane. we looked at hormonal and urinary thromboxane levels in 48 postmenopausal and 52 premenopausal women. we found that postmenopausal women had higher levels of utxb2 than did premenopausal women (2495 vs. 2299, p=.02) and that in premenopausal women a higher estrogen/progesterone ratio was associated with the highest levels of urinary thromboxane. the goal of the current study is to measure the response to seven days of aspirin administration as it relates to urinary thromboxane levels in pre and post-menopausal women. with this study we will be able to examine the change in utxb2 comparing the premenopausal to post menopausal women. we will also be able to see if the change in utxb2 in response to aspirin is affected by hormone levels in the premenopausal women. lastly this study will provide reference data for more far-reaching studies exploring how global changes in hormonal balance (as seen in pregnancy or menopause) or in the level of inflammation (as seen in aging or with coronary artery disease (cad) risk factors), affect utxb2 and platelet hyperreactivity.

Eligibility criteria:
inclusion criteria: 1. women age 18-80 2. signed informed consent. exclusion criteria: 1. history of cad, cerebrovascular accident (cva) or peripheral artery disease (pad), 2. on chronic aspirin therapy, 3. on chronic nsaid therapy. 4. chronic anticoagulation with coumadin, 5. known thrombocytopenia (platelet count \< 100,000), 6. pregnancy (self-report), 7. currently on any type of contraceptive or hormone replacement therapy, 8. hysterectomy and/or oophorectomy. 9. recent gi bleeding 10. bleeding diathesis 11. chronic systemic infection

Keywords: acute coronary syndrome clotting hormones women
future patient - telerehabilitation of patients with atrial fibrillation

Conditions: Atrial Fibrillation

Summary: this project has focus on patients with atrial fibrillation testing a telerehabilitation program for patients with atrial fibrillation.

the overall aim of the fp-af program is to increase quality of life by giving the patients and relatives more knowledge about atrial fibrillation, its symptoms, and the issues of living with atrial fibrillation in everyday life. the specific aims are to individualize the rehabilitation process and help the patients and relatives develop their own self-management strategies using their own clinical data and their enhanced knowledge about af.

Eligibility criteria:
inclusion criteria: * patients diagnosed with atrial fibrillation * adults over 18 years * living in skive, viborg or silkeborg municipalities * living at home and capable of caring for themselves * have basic computer skills or having a relative/friend with basic computer skills exclusion criteria: * pregnancy * refusal or inability to cooperate; or patient not does not speak, read or understand danish * life expectancy less than a year

Keywords: telerehabilitation quality of life cardiac patients atrial fibrillation
safety study of feeding with ginger extract in acute respiratory distress syndrome

Conditions: Acute Respiratory Distress Syndrome

Summary: an enteral diet supplemented with ginger extract in acute respiratory distress syndrome (ards) patients may be beneficial for gas exchange and could decrease duration of mechanical ventilation and length of stay in intensive care unit (icu).

rationale: clinical ards occurs primarily as the result of inflammatory injury to the alveoli producing diffuse alveolar damage. objective: to evaluate the effects of an enteral diet enriched with ginger extract on inflammatory factors, respiratory profile and outcome of patients with ards. methods: in this single center, randomized, controlled double blind study, 32 patients with ards were randomized to receive a high protein enteral diet enriched with ginger extract or placebo. measurements and main results: serum levels of il-1, il-6, tnf-α and ltb-4, oxygenation, measured as pao2/fio2, static compliance measured on days 0, 5 and 10. patients fed enteral diet enriched with ginger extract had significantly lower serum levels of il-1, il-6, tnf-α and ltb-4 on days 5 and 10 compared to control group (p\<0.05). significant improvement in oxygenation was observed on day 5 (p=0.02) and 10 (p=0.003) in ginger extract group compared to control group. static compliance was also increased significantly on day 5 (p=0.01) in ginger extract group compared to control group. a significant difference was found in duration of mechanical ventilation (p0.02) and length of icu stay (p=0.04) in favor of ginger extract group. we did not find any difference in barotraumas, organ failure and mortality between the study groups. conclusions: an enteral diet supplemented with ginger extract in ards patients may be beneficial for gas exchange and could decrease duration of mechanical ventilation and length of stay in icu.

Eligibility criteria:
inclusion criteria: * required positive pressure ventilation via endotracheal tube or tracheostomy and were on enteral nutrition support. * also they had to have an acute onset of significantly impaired oxygenation with a pao2 to fio2 ratio equal or less than 200, bilateral pulmonary infiltrates on frontal chest radiograph and no clinical evidence of left atrial hypertension according to the american-european consensus conference on ards . * patients had to be enrolled within 48 hours of developing these criteria. exclusion criteria: * age younger than 18 years * participation in other interventional trials in the previous 30 days * neurological conditions that could impair weaning from ventilatory support, * severe chronic respiratory disease * pregnancy * lactation * active bleeding * head trauma * intracranial hemorrhage * peptic ulcer * hiv infection * food allergy * morbid obesity * malignancy or other irreversible conditions for which 6 months mortality was estimated to be 50% or more and who were receiving nonsteroidal anti inflammatory drugs or ketoconazole.

Keywords: ginger extract ards enteral feeding mechanical ventilation icu
interest of a nursing consultation in the empowerment of the patient with rheumatoid arthritis in the management of his subcutaneous biotherapy

Conditions: Biotherapies; Rheumatology; Rheumatoid Arthritis

Summary: biotherapy present specifics risks that patients must know and learn to manage. a national survey has been carried in this study to evaluate patients safety skills. (wording: " cross study of safety skills of 677 patients treat by biopharmaceuticals for an inflammatory rheumatism). this survey has allowed showcasing patients difficulties in managing their treatment, including for those under subcutaneous biotherapy. more than 60% patients interviewed doesn't know symptoms to bring them to consult and mainly postpone to their injection. the aim of this study is to prove that nursing consultation can allow the patient to become independent in treatment management and thus avoid occurrence of adverse event.


Eligibility criteria:
inclusion criteria: * patient suffering from rheumatoid arthritis followed by rheumatology consultation of amiens-picardie university hospital * patient treated by subcutaneous biotherapy for at least 6 months at the time of inclusion * major patient * patient having signed an informed consent exclusion criteria: * minor patient * patient with cognitive impairment diagnosed by a physician * patient under tutorship or curatorship * patient deaf or hard of hearing * patient not fluent in the french language (at the decision of the investigator)

Keywords: nurse consultation biotherapies rheumatology rheumatoid arthritis
vaginal tactile imaging for the assessment of pelvic organ prolapse repair efficiency

Conditions: Pelvic Organ Prolapse

Summary: female patients with pop will be evaluated for vaginal elasticity using vaginal tactile imaging both before and after surgery for the repair of the pop. surgical repair will be performed by a single surgeon who will perform either a laparoscopic or vaginal repair.

patients will be recruited and sign a consent form. the patients included are patients with pop that are candidates for either laparoscopic or vaginal repair. assessment of vaginal elasticity via vaginal tactile imaging will be performed at 3 different points: * the day of surgery before surgery. * the day after surgery. * 3 months post-operational. every patient will serve as her own control. demographic, gynecologic and obstetric history will be obtained from patients' electronic files.

Eligibility criteria:
inclusion criteria: * any woman undergoing pop repair exclusion criteria: * women above or below the age limit
infection with unknown origin in the emergency department

Conditions: Infection

Summary: patients suspected with infection is one of the major groups, who are admitted to the danish emergency departments (ed). currently, there is no overall description of the distribution of these infections. the aim of this study is to characterize ed patients with a suspected infection whereby the focus of the infection is of an unknown origin.

bacteria resistant to antibiotics are associated with high antibiotic consumption and are identified by the world health organisation as a major public health threat. despite efforts to optimize antibiotic consumption in denmark, the total consumption in the hospital sector increased from 2009-2018 and the incidence of multi-resistance bacteria (mrb) is increasing. a danish multicenter study has shown that every 20th patient in the emergency department has mrb. patients with an infection of unknown origin tend to be prescribed a broad-spectrum antibiotic, as physicians endeavour to target probable origins in the body. the uncertainty associated with the diagnosis may lead to an overconsumption of antibiotics, which contributes to increased development of resistant bacteria and threatens future treatment options. the aim of this study is to characterize patients admitted to the ed suspected with infection. the study will have three objectives: * to describe the distribution of ed infections according to the registered diagnosis in the medical record compared to a clinical expert panel assessment * to identify clinically relevant information available at admission associated with a patients infection of unknown origin. * to investigate the association between an adverse event and clinically relevant information for patients with infection of unknown origin the investigators' hypothesis is that with an improvement of knowledge about patients with an infection of unknown origin, a more accurate diagnosis can be made leading to a more appropriate antibiotic therapy and contributing to the fight against resistance to antibiotics.

Eligibility criteria:
inclusion criteria: * adults admitted to the ed will be invited to participate in the study, if the physician, receiving the patient, suspect the patient has an infection (e.g. indication for blood culture). exclusion criteria: * if the attending physician considers that participation will delay a life-saving treatment or patient needs direct transfer to the intensive care unit. * admission within the last 14 days * verified covid-19 disease within 14 days before admission * pregnant women * severe immunodeficiencies: primary immunodeficiencies and secondary immunodeficiencies (hiv positive cd4 \ 20 mg/day prednisone or equivalent for \>14 days within the last 30 days), chemotherapy within 30 days)

Keywords: antibiotics source diagnosis fever pyrexia
measuring the incidence of hospital readmissions based on adverse drug events

Conditions: Incidence of Readmissions; ADE's Due to Anticoagulants

Summary: an ade is defined as harm caused by a drug or the inappropriate use of a drug. retrospective record reviews in several countries have shown that anticoagulants frequently lead to hospital readmissions. in this study a hospital readmission is defined as an admission to the emergency department of the jessa hospital. the objective of this study is to determine the incidence of one week and 30-day readmissions caused by (preventable) ade's due to anticoagulants.


Eligibility criteria:
inclusion criteria: 1. patients who received an anticoagulant on their last day of admission 2. patients who were readmitted within 30 days 3. patients who were diagnosed using the pathology registration of the emergency department of the jessa hospital exclusion criteria: 1. patients who didn't receive an anticoagulant on their last day of admission 2. patients who were not readmitted within 30 days 3. patients who were not diagnosed using the pathology registration of the emergency department of the jessa hospital 4. patients with missing data
a study assessing the effects of acupuncture in parkinson's disease patients with chronic appendicitis

Conditions: Parkinson's Disease; Chronic Appendicitis; Acupuncture

Summary: the incidence of pd is high, and when the disease is serious to a certain extent, the effect of drugs to control symptoms decreases, resulting in a significant reduction in the quality of life of patients. recent studies have found that these pd symptoms are closely related to the intestine. for several cases of pd syndrome patients complicated with chronic appendicitis, our research group conducted acupuncture on points related to constipation and chronic appendicitis, and found that constipation and related motor symptoms of patients could be significantly improved. clinical studies have shown that acupuncture also has a certain therapeutic effect on non-motor symptoms of parkinson's disease, such as anxiety and depression, decreased olfactory function, sleep disorders, constipation, early skeletal muscle pain, cognitive dysfunction, etc., which can delay the progression of the disease and improve the quality of life of patients. starting from intestinal acupuncture, this project further clarified the role of acupuncture treatment in the comprehensive treatment of pd


Eligibility criteria:
inclusion criteria: * patients presenting with bradykinesia, combined with resting tremor and/or myotonia. * appendix ct suggested chronic appendicitis evaluated by two experienced experts. * all subjects and their guardians give informed consent to the content of this study and sign informed consent. * normal coagulation function. * if the patient had taken oral anti-pd drugs, it had been stable for at least 2 weeks at enrollment. exclusion criteria: * treatment with dopamine blockers or dopamine depleters in doses and time courses consistent with drug-induced parkinsonism. * neuroimaging examination of presynaptic dopaminergic system function was normal. * patients who had suffered severe brain trauma or underwent complex craniotomy within 5 years prior to enrollment. * cognitive disorders that are not on the parkinson's spectrum, such as alzheimer's disease, frontotemporal dementia, and niemann-pick disease, have been diagnosed. * people diagnosed with severe neuropsychiatric disorders (epilepsy, bipolar disorder, major depressive episode, etc.) according to dsm-v. * complicated with serious systemic diseases, disorders of consciousness, stroke, serious coronary heart disease, diabetes, liver and kidney diseases, and serious visual and hearing disorders. * patients with severe organic or functional dysphagia;those who were deemed by the researcher to be unable to complete the visit and auxiliary examination as required by the study protocol.

Keywords: parkinson's disease acupuncture
compare foflox4 in preoperative and postoperative and postoperative in resectable liver metastasis colorectal cancer (mcc)

Conditions: Colorectal Cancer; Liver Metastasis

Summary: this study is a multicenter, open-label, randomized ,controlled phase iii study to compare preoperative and postoperative with foflox4 chemotherapy and postoperative with foflox4 chemotherapy in patients with resectable liver metastasis from colorectal cancer.

to investigate the three-year progression free survival (pfs) advantage of folfox4 in the treatment of resectable metastatic colorectal cancer.

Eligibility criteria:
inclusion criteria: 1. resectable liver metastasis from colorectal cancer(the distance from the tumor lower edge to anal more than 12cm),no visible extrahepatic metastatic tumors. curable by resection, as determined by a surgeon and imaging physicians. the minimum of the liver metastases needs ≥2cm. patients can be recruited if meet the conditions about: * primary tumor had been removed of the metachronous liver metastasis patients and no residue from the eyes or microscope. * primary tumor has been removed more than 1 month of the simultaneous liver metastasis patients. 2. age of≥18 and ≤80 3. ecog≤2 4. signed written informed consent exclusion criteria: 1. peripheral neuropathy(ctc\>1) 2. had a neurological or mental disorders 3. active infection 4. allergy to platinum-based and other drugs 5. other acute diseases including infection, heart-disease(chf, stable or unstable angina) 6. pregnant or nursing patients

Keywords: foflox4 resectable liver metastasis from colorectal cancer
dupilumab in adolescent and adult skin of color participants: open-label moderate-to-severe eczema trial

Conditions: Moderate-to-Severe Atopic Dermatitis; Atopic Eczema

Summary: the study is focused on skin of color participants who have moderate-to-severe atopic dermatitis. atopic dermatitis, also referred to as eczema, is a condition that causes the skin to become itchy, dry, and cracked. from the previous studies on the study drug, it is seen that the study drug has an acceptable safety and effectiveness in participants with atopic dermatitis. the aim of this study is to get additional information on the safety and effectiveness of the study drug, particularly the information on aspects of atopic dermatitis in skin of color participants. the study is looking at several other research questions, including: * what side effects may happen from taking the study drug * how much study drug is in your blood at different times * how much the study drug improves quality of life and mental health


Eligibility criteria:
key inclusion criteria: 1. skin of color, defined as fitzpatrick skin type ≥4 at screening visit 2. diagnosis of moderate-to-severe atopic dermatitis (ad) that cannot be adequately controlled with topical ad medications, as defined in protocol 3. has applied a stable dose of topical emollient (moisturizer) twice daily as per physician recommendation starting at screening visit key exclusion criteria: 1. self-reported caucasian or white race 2. adolescent body weight less than 30 kg at screening 3. prior use of dupilumab within 6 months of screening 4. concomitant skin diseases or other pigmentary disorder that could confound ad assessments 5. current or prior use, within 12 weeks before the screening visit, of phototherapy or tanning beds 6. active helminthic infections; suspected or high risk of helminthic infection, unless clinical and (if necessary) laboratory assessments have ruled out active infection before baseline 7. treatment with topical corticosteroids (tcs) or topical calcineurin inhibitors (tci) within 7 days prior to baseline 8. planned or anticipated use of any prohibited medications and procedures, as defined in protocol 9. has received a covid-19 vaccination within 1 week of planned start of study medication or for which the planned covid-19 vaccinations would not be completed 1 week prior to start of study drug note: other protocol defined inclusion / exclusion criteria apply

Keywords: eczematous lesions pruritus