Kornimate/medical-research-clean huggingface dataset:
multicentre trial of suboxone in opiate-dependent subjects in taiwan

Conditions: Opiate Dependence

Summary: to determine whether suboxone can be effectively used to treat taiwanese ethnic subjects with opiate dependence.


Eligibility criteria:
inclusion criteria: * male or female subjects, 20 years of age or older at screening visit. * subjects must meet dsm-iv/cows1,2 criteria for opiate dependence. (cows total score ≥5) * subjects must have a positive urine drug screen (dipstick test) for an opiate or morphine at study entry * subject is seeking treatment with the desire to discontinue opiate use as an initial goal but willing to consider and accept longer treatment if necessary. * subject is in good physical health or, if he/she has a medical condition needing ongoing treatment, must be in the care of a physician who is willing to take responsibility for such treatment and work with the study physician. study physicians able to manage the subject for his/her general medical condition, may be assigned this role. these same conditions apply in case of subjects with psychiatric disorder(s) needing ongoing treatment. * subject is agreeable to and capable of signing informed consent form. * females of childbearing potential must have a negative pregnancy test and agree to use a double barrier method or condoms/diaphragm and spermicide contraceptive method during the study. exclusion criteria: * women who are pregnant, lactating or breast feeding. * subjects have any acute medical condition that would make participation, in the opinion of the treating physician or the principal investigator, medically hazardous (e.g., acute hepatitis, unstable cardiovascular, liver or renal disease). * subjects have clinically significant liver disease. * subjects who have demonstrated a previous hypersensitivity to buprenorphine or naloxone. * subjects who are considered an immediate risk for suicide, are acutely psychotic, severely depressed, or in need of inpatient treatment. * subjects who are dependent on alcohol, benzodiazepines or other drugs of abuse (except tobacco) to the point of requiring immediate medical attention. * subjects received methadone treatment within the last 30 days since screening visit. * subjects have any pending legal action that could prohibit continued participation. * subjects have participated in other clinical studies within the past 30 days. * subjects who are expecting to leave the clinic geographic area prior to study completion.

Keywords: buprenorphine naloxone suboxone
project matlink: development and evaluation of a screening, brief intervention, & referral to treatment (sbirt) program for opioid dependent prisoners and probationers transitioning to the community

Conditions: Opioid-use Disorder; HIV Infections; Tuberculosis; Hepatitis C; Hepatitis B; Depression; Syphilis

Summary: the purpose of this study is to evaluate the efficacy a screening, brief intervention, and referral to treatment (sbirt) program for linking opioid dependent individuals currently incarcerated or in probation in moldova, kyrgyzstan, and ukraine to opioid substitution therapy in the community after release or during their probation period.


Eligibility criteria:
inclusion criteria: 1. 18 years of age or older 2. within 180 days of release or possible release (eligible for parole) to the community, but greater than 7 days to release to the community or currently in probation. 3. for those in prison: relocating to a location within 30 km (approximately 60-minute commute) of the referred narcology center. each participant will be asked the address he/she is planning to reside under that will be immediately checked on the map to determine the travel time. a participant then will be asked if he/she would be willing to travel the distance to a particular oat site. if a person does not meet this inclusion criterion, he/she will be referred to a local harm reduction center. 4. meets icd-10 screening criteria for pre-incarceration opioid dependence for those in probation: 5. living within 30 km of an oat delivery site 6. not having received oat in the last 15 days. 7. positive for oud exclusion criteria: 1. pregnant or may become pregnant 2. for those in prison: will be released from prison in 7 days or less.

Keywords: hiv oud methadone hcv hbv tb depression syphilis
patient satisfaction and peri-implant tissue success of hybrid ceramic versus e-max superstructures

Conditions: Prosthesis Survival

Summary: in patients receiving implants in the esthetic zone, would the use of new nano hybrid ceramic crown material (crystal ultra) improve esthetic patient satisfaction and peri-implant tissue success when compared with lithium disilicate crown (e-max)?

the patient will be treated in visits designated as follows: visit 1: preoperative records, face-to-face adherence reminder session, signing consents, clinical, radiographic examination and primary impression for diagnostic cast construction. visit 2: (first stage surgery): implant placement surgical procedure and postoperative radiograph. visit 3: after 3months (second stage surgery): re-opening of surgical site, placement of healing abutments and temporary crowns. visit 4: after 2 weeks, removing of temporary restorations and taking of final impressions visit 5: placement of different ceramic crown superstructures and recording different outcome values.

Eligibility criteria:
inclusion criteria: 1. age above 18 years with at least one tooth missing in the esthetic area. 2. available bone for implant placement: a. labial and palatal plate of bone not less than 2mm. b. mesio- distal dimension not less than 6.5mm. c. bone length not less than 9mm. 3. patient with good oral hygiene. 4. class 1 occlusion. 5. lack of excessive parafunctional activity leading to implant failure. 6. tooth extracted not less than 6 month. exclusion criteria: 1. young patients in whom the jaws are still growing. (less than 18 years). 2. jaw pathology. 3. smokers. 4. uncontrolled diabetic or particularly insulin-dependent. 5. radiotherapy to the neck or face. 6. multiple loss of teeth which may be indicated for more complicated procedure.
multimodal analgesia after shoulder arthroscopy

Conditions: Analgesia; Arthroscopy; Shoulder Joint

Summary: this proposal aims to measure the quality of recovery and quality of pain management after shoulder surgery before and after implementation of a multimodal pain protocol.

pain management after shoulder surgery remains to be a major challenge. reliance on a single agent (most commonly opioids) results in increased incidence of side effects. multimodal pain management refers to the use of multiple drugs that target different components of pain pathway.

Eligibility criteria:
inclusion criteria: * adult patients * age 18-80 * speaks and understands the english language * have a phone number * scheduled for shoulder arthroscopy exclusion criteria: * inability to read or speak english * individuals outside of age range * pregnant women * persons under the jurisdiction of the department of corrections

Keywords: multimodal analgesia quality of recovery quality of pain management
randomized trial of osteoporosis intervention strategies in hip fracture patients

Conditions: Osteoporosis; Hip Fracture

Summary: patients with hip fractures have suffered the most devastating consequence of osteoporosis; and yet, they are rarely if ever tested or treated for the condition, even though they remain at high risk of recurrent fracture. we hypothesize that, compared with usual care, an allied health professional-run osteoporosis service (case management) will be able to increase testing and treatment of osteoporosis in patients at high risk of fracture.

patients with hip fractures have suffered the most devastating consequence of osteoporosis; and yet, they are rarely if ever tested or treated for the condition, even though they remain at high risk of recurrent fracture. we hypothesize that, compared with usual care, an allied health professional-run osteoporosis service (case management) will be able to increase testing and treatment of osteoporosis in patients at high risk of fracture.

Eligibility criteria:
inclusion criteria: * hip fracture patient \> 50 years of age * able to give consent (or proxy consent available) * lives within health region * no contraindications to bisphosphonate therapy exclusion criteria: * refuses to participate or consent * dementia or delirium without a proxy consent available * nursing home or longterm care * pathologic fracture * chronic glucocorticoid use * already receiving prescription osteoporosis treatment (calcium and vitamin d do not preclude inclusion)

Keywords: osteoporosis treatment osteoporosis testing hip fracture quality improvement
comparison of short-term outcomes of robotic and laparoscopic surgery in patients with different body mass index for mid and low rectal cancer

Conditions: Rectal Cancer

Summary: numerous comparison studies on the outcomes of robotic and laparoscopic surgery in the treatment of rectal cancer have been undertaken and reported. but there aren't many studies that compare the safety and effectiveness of the two surgery procedures used to treat people with mid and low rectal cancer who have different body mass indexes (bmis). this study was done to organize the clinical data we had at our hospital so we could compare the perioperative effectiveness of two minimally invasive approaches for people with different bmis.


Eligibility criteria:
inclusion criteria: the inclusion decision was made based on the following criteria: the results of the preoperative evaluation revealed the existence of adenocarcinoma in the middle to lower rectum (less than 10 centimeters distant from the anal edge); received a drastic operation that might have been laparoscopic or robotic and was based on the principle of tme; distant metastases that are non-conformist or heteroclinic, and there are no additional malignant tumors present at the same time as the operation. exclusion criteria: a high tumor location that was more than 10 centimeters away from the anal margin; surgery was unsuccessful in completing anal preservation due to invasion of the external anal sphincter; cancerous obstruction or perforation; severe cardiopulmonary dysfunction classified as stage iv according to the asa score; and poor preoperative anal function; any resection that is performed in combination, rather than being a r0 resection.
occupational self analysis in people with a serious mental illness.

Conditions: Intervention; Control Condition

Summary: in this study we test the efectiveness of an intervention called 'occupational sefl-analysys' where particiapants are taught to analyze what activities they do and why do they choose those activities. also they are encouage to reflect about those occupations that don't do but will like to. in case they want to , they can make changes in their occupational routines. after he program we assessed the improvements in life satisfaction, participation in meaningful activities, perception of balance and occupational satisfaction,

the appearance of a mental disorder forces the person to modify their occupational choices and participation, due, among other aspects, to the continuous presence of symptoms and relapses. 'occupational self-analysis' programs are based on increasing occupational awareness to promote changes in meaningful occupational participation. the objective of this study was to test the effectiveness of the 'occupational self-analysis' program in people with serious mental disorder specially on life satisfaction, participation in meaningful activities, perception of balance and occupational satisfaction, compared to the standard intervention received in a therapeutic community of mental health. the program was implemented for 4 months, twice a week, while the control group received the standard treatment. ten people participated in the 'occupational self-analysis' program. results show that participants improved their perception of occupational balance and occupational satisfaction, as well as increasing their participation in meaningful activities.

Eligibility criteria:
inclusion criteria: * having a serious mental illness * living in the therapeutic community or attend the device's day program. exclusion criteria: * havin acute psychopathology * diagnosis of cognitive impairment * dependence or abuse of toxic substances

Keywords: occupational self-analysis occupational balance occupational satisfaction serious mental disorder meaningful activities
euglycemia after antenatal late preterm steroids, the e-alps study

Conditions: Pregnancy Preterm; Neonatal Hypoglycemia; Hyperglycemia Drug Induced

Summary: annually in the u.s 300,000 neonates are born late preterm, defined as 34 weeks 0 days - 36 weeks 6 days. the antenatal late preterm steroids (alps) trial demonstrated that maternal treatment with betamethasone in the late preterm period significantly reduces neonatal respiratory complications, but also increases neonatal hypoglycemia, compared to placebo. this research study will attempt to answer the following primary question: does a management protocol aimed at maintaining maternal euglycemia after alps decrease fetal hyperinsulinemia, compared to usual antepartum care?

euglycemia after antenatal late preterm steroids, the e-alps study: there is a fundamental gap in understanding the adverse metabolic effects of antenatal late preterm steroids (alps). in 2016, an important randomized clinical trial of 2827 late preterm pregnancies showed that antenatal betamethasone (bmz) significantly reduced neonatal respiratory complications compared with placebo. however, those neonates exposed to bmz were also more likely to have hypoglycemia at birth. this unexpected adverse outcome raised concern among both obstetricians and neonatologists and remains an important knowledge gap to be filled. the rationale for the proposed research is that steroid-induced maternal hyperglycemia leads to transient fetal hyperinsulinemia, which causes hypoglycemia in neonates that are delivered during this time-period. thus, the fetal metabolic consequences and subsequent neonatal hypoglycemia observed after exposure to bmz in utero can be prevented by achieving maternal euglycemia prior to delivery. this protocol describes a randomized clinical trial to evaluate whether screening for and treatment of steroid-induced hyperglycemia in non-diabetic women treated with bmz in the late preterm period can decrease the rate of fetal hyperinsulinemia, thus reducing neonatal hypoglycemia and improving short-term neonatal outcomes. this study was formerly approved as institutional review board #16-3200.

Eligibility criteria:
inclusion criteria: * singleton gestation with no known major fetal anomalies * gestational age at randomization between 34 weeks 0 days and 36 weeks 5 days * receiving antenatal betamethasone due to high probability of delivery in late preterm period exclusion criteria: * pre-gestational or gestational diabetes mellitus * maternal contraindication to insulin * planned outpatient treatment with antenatal betamethasone * participation in clinical trial that could affect primary outcome or participation in this trial in a previous pregnancy

Keywords: betamethasone late preterm steroids
symptomatic trial of angina assessment prior to revascularization

Conditions: Coronary Artery Disease; Angina, Stable

Summary: the principal objective of this research is to determine whether symptoms, induced by confirmed experimental ischaemia, can help us predict which patients will respond to pci.


Eligibility criteria:
inclusion criteria: 1. angina or angina-equivalent symptoms 2. anatomical evidence of a significant single vessel coronary stenosis on diagnostic coronary angiography indicating ≥ 70% stenosis 3. referred for percutaneous coronary intervention for treatment of stable angina exclusion criteria: 1. age younger than 18 2. age older than 85 3. recent acute coronary syndrome 4. multivessel coronary artery disease 5. previous coronary artery bypass graft surgery 6. significant left main stem coronary disease 7. chronic total occlusion in the target vessel 8. contraindication to percutaneous coronary intervention or drug-eluting stent implantation 9. contraindication to antiplatelet therapy 10. contraindication to adenosine infusion 11. severe valvular disease 12. severe lv systolic impairment 13. severe respiratory disease 14. life expectancy less than 2 years, pregnancy, unable to consent
iop fluctuations in patients with sleep apnea with or without primary open angle glaucoma using positive airway pressure

Conditions: Sleep Apnea, Obstructive; Primary Open-angle Glaucoma

Summary: sleep apnea is characterized by repetitive episodes of decreased or interrupted airflow in the upper airways during sleep. obstructive sleep apnea syndrome (osas) is the most common sleep-related breathing disorder and is characterized by repeated partial or complete upper airway collapse, gasping episodes, daytime sleepiness and fatigue. once suspected, the diagnosis is made on the basis of anamnesis and a polysomnography (psg) using the so-called respiratory disturbance index (rdi) to grade osas. standard therapy consists of continuous positive airway pressure (cpap) during sleep to prevent upper airway collapse. the association between osas and glaucoma has been extensively studied, although a few reports have been non-confirmatory. osas has been associated with reduced ocular blood flow, leading to hypoxia and hypercapnia, and as such, may represent a risk factor for glaucomatous optic neuropathy. osas has also been related to loss of nycthemeral rhythm of intraocular pressure (iop). in addition, cpap has been reported to increase iop when used during nighttime. the purpose of this study is to investigate how iop varies in time, particularly during sleep in osas patients with or without glaucoma, and if the iop variations are associated with the use of cpap. iop fluctuations will be monitored with sensimed triggerfish®, a portable investigational device using a contact lens sensor that monitors the iop fluctuation continuously over 24-hours.


Eligibility criteria:
inclusion criteria: * patients with a confirmed diagnosis of moderate to severe osas, determined by a rdi \> 15 on psg * patient has either poag with controlled iop or no glaucoma. five of each will included in the study * patients under cpap therapy * aged ≥ 18 years, of either sex * not more than 4 diopters spherical equivalent on the study eye * not more than 2 diopters cylinder equivalent on the study eye * have given written informed consent, prior to any investigational procedures exclusion criteria: * sleep disorders other than osas * use of sleep medication * patients with history of intraocular surgery (including laser therapy) within the last 3 months * corneal or conjunctival abnormality hindering contact lens adaptation * severe dry eye syndrome * patients with allergy to corneal anesthetic * patients with contraindications for silicone contact lens wear * patients not able to understand the character and individual consequences of the investigation * participation in other clinical research within the last 30 days
exploring potential associations between rurality and hopelessness in ihd patients

Conditions: Cardiac Disease; Mental Health Issue

Summary: hopelessness is associated with 3.4 times increased risk of mortality or nonfatal myocardial infarction in patients with ischemic heart disease (ihd), independent of depression. hopelessness has been identified in 27-52% of patients with ihd and can persist for up to 12 months after hospital discharge. hopelessness, a negative outlook and sense of helplessness toward the future, can be a temporary response to an event (state) or a habitual outlook (trait). hopelessness is associated with decreased physical functioning and lower physical activity (pa) levels in individuals with ihd. low levels of pa independently contribute to increased death and adverse events in patients with ihd. rates of pa in ihd patients continue to be unacceptably low in both hospital-based cardiac rehabilitation and home settings. compounding this issue is often the symptom of hopelessness. the links among hopelessness, pa and mortality and morbidity for patients with ihd remain largely unknown, especially in rural and minority ihd patients. the purpose of this study is to delineate differences in hopelessness between urban and rural patients with ihd, as well as between racial minority, including hispanic and native american, and white patients with ihd. potential mediation of urbanicity and race/ethnicity by social connectedness, a key variable in rural settings, will also be examined. a 6-month longitudinal study will be conducted at sanford heart hospital and avera health in sioux falls, south dakota. hopelessness will be measured using the state-trait hopelessness scale. the results of this study have potential to transform nursing practice by providing a better understanding of hopelessness in ihd patients and informing future exercise rehabilitation studies and interventions in rural and minority populations.


Eligibility criteria:
inclusion criteria: * myocardial infarction or unstable angina or having undergone a percutaneous coronary intervention or coronary artery bypass surgery * ≥ 18 years * planned discharge home * cognitive and physical ability to complete the study measures. exclusion criteria: * none

Keywords: rurality
macrowire for intracranial thrombectomy

Conditions: Stroke, Acute Ischemic

Summary: the aim of this study is to develop a multicenter database of patient data and outcomes for patients undergoing intracranial thrombectomy for acute ischemic stroke secondary to emergent large vessel occlusion with delivery of reperfusion catheter over a novel macrowire (aristotle colossus) to perform intracranial mechanical thrombectomy.


Eligibility criteria:
inclusion criteria: age \>18-85 years time of onset \ 6 ct-aspects ≥ 6 proven intracranial occlusion - (ica-t, m1) modified rankin score: 0-2 exclusion criteria: age \ 85 years unknown time of onset nihss \ 2 tandem occlusion
nitroglycerin as spasmolytic regimen for ras prevention in radial center

Conditions: Radial Artery Injury

Summary: the investigators will investigate whether administration of nitroglycerin (ntg) as spasmolytic regimen reduces the incidence of moderate to severe radial artery spasm (ras) in patients undergoing transradial catheterization in radial center.

patients will be randomized to receive either 200 microgram ntg or placebo (saline) at the beginning of the procedure soon after radial sheath placement. the operators will be blinded to both assignment. the primary outcome is the incidence of moderate to severe ras evaluated by the operators during the radial procedure. both ntg and placebo will be administered using an identical syringe to keep the operators blinded to the treatment allocation. radial angiogram is mandatory to measure the diameter of both radial and ulnar arteries. doppler ultrasound of the radial artery will be examined at the day after the procedure.

Eligibility criteria:
inclusion criteria: * all patients undergoing transradial catheterisation using proximal radial artery puncture technique exclusion criteria: * blood pressure \<100 mmhg * refuse to participate

Keywords: transradial catheterisation radial artery spasm