Kornimate/medical-research-clean huggingface dataset:
metformin in assisted reproduction-met-ar-study

Conditions: Polycystic Ovary Syndrome

Summary: aim of study: to investigate whether four months of metformin treatment before ivf (in-vitro-fertilisation) or icsi (intra-cytoplasmic-sperm-injection) might increase clinical pregnancy rate in normal-weight (body mass index \[bmi\] below 28 kg/m3) in pcos (polycystic ovarian syndrome) women.

pcos is an hormonal disease including hyperandrogenism, oligo-or anovulation and/or polycystic ovaries by ultrasound. pcos women often suffer insulin resistance or even diabetes risk as well as a full blown metabolic disease. these women often suffer infertility due to their lack of regular ovulations. metformin is a well known anti-diabetic drug, and in some pcos women metformin might decrease the hyperandrogenism, improve insulin resistance and give more regular ovulations. thereby increase chance of pregnancy. our hypothesis is that metformin will increase clinical pregnancy rates both spontaneously and following ivf/icsi.

Eligibility criteria:
inclusion criteria: * fulfilling rotterdam criteria for pcos * infertility more than 1 year * first or second cycle of ivf/icsi treatment * age below 38 years at inclusion * bmi below 28 kg/m3 at inclusion * willing to be randomised to 4 months metformin or placebo * signed written informed consent exclusion criteria: * not suitable for starting dose 112.5 ie * basal fsh above 10 iu/l * known renal disease or s-creatinine above 110 umol/l * known liver disease or s-alat above 80 iu/l * known alcoholism or drug abuse * known diabetes mellitus or fasting plasma glucose above 7 mmol/l * corticosteroid treatment (oral) * treatment with cimetidine, anticoagulants, erythromycin or other macrolides * hyperprolactinemia (prl above 700 miu/l) * abnormal thyroid function tests * known congenital adrenal hyperplasia * androgen secreting tumours * cushing syndrome * metformin treatment within the last one month prior to screening * unfit to participate for any other reason

Keywords: polycystic ovarian syndrome clinical pregnancy rate oligo- or anovulation
novel arm restraint in the intensive care unit

Conditions: Acute Respiratory Failure

Summary: the goal of this pilot is to evaluate a novel restraint device in 8 older mechanically ventilated patients to demonstrate that 1) the revised novel restraint prototype is safe and 2) a future randomized controlled trial (rct) is feasible.

the goal of this fast-track small business technology transfer (sttr) project is to optimize and test a novel arm restraint in older critically ill mechanically ventilated patients that may increase mobility; reduce agitation, use of sedative medications, and delirium; and exhibit high satisfaction and acceptability among hospital staff, family members, and patients. older mechanically ventilated patients are often immobilized with wrist restraints to prevent self-extubation and are sedated to reduce agitation caused by their restraints and endotracheal (breathing) tube. this sedation and immobility lead to complications, including delirium and muscle weakness, that are independently associated with long term cognitive impairment, reduced physical functioning, and mortality. specifically, the incidence and duration of delirium in the icu are strongly and independently associated with long-term cognitive impairment that is similar to alzheimer's disease and related dementias. healthy design has developed a novel restraint device that allows arm mobility but prohibits hands from reaching oral/nasal endotracheal and feeding tubes or intravenous lines. because it permits mobility, the novel restraint may reduce agitation and the need for sedatives. the objectives of this pilot study are to evaluate the novel restraint in 8 older mechanically ventilated patients to demonstrate that 1) the revised novel restraint prototype is safe and 2) a future rct is feasible.

Eligibility criteria:
inclusion criteria: 1. \>65 years old 2. physician order for use of bilateral wrist restraints 3. requiring mechanical ventilation with actual or expected total duration of \>48 hours 4. expected icu stay \>3 days after enrollment (to permit adequate exposure to proposed intervention) 5. not deeply sedated (richmond agitation sedation scale \[rass\] score \> -2) exclusion criteria: 1. upper extremity impairments that prevent use of novel restraint device (e.g. amputation, arm injury) 2. limited mobility of either upper extremity prior to admission (e.g. frozen shoulder, severe arthritis) 3. pre-existing primary systemic neuromuscular disease (e.g. guillain-barre) 4. neuromuscular blocker infusion (eligible once infusion discontinued if other inclusion criteria met) 5. pre-existing severe cognitive impairment or language barrier prohibiting outcome assessment 6. expected death or withdrawal of life-sustaining treatments within 6 days from enrollment 7. incarcerated 8. severe skin breakdown on either upper extremity
personality profile of patients with apical ballooning syndrome

Conditions: Apical Ballooning Syndrome

Summary: the investigators' hypothesis is that patients with apical ballooning syndrome (abs) will manifest a personality profile that differs than that of a population of similar range of ethnic and socioeconomic status.


Eligibility criteria:
inclusion criteria: 1. patients who have suffered with abs 2. adults (18 years or older) 3. able to read english at a 6th grade level (questionnaires are self-administered and written in english) exclusion criteria: 1. have withdrawn from the registry 2. have died

Keywords: apical ballooning syndrome personality
reproductibility of cystometry in multiple sclerosis patient

Conditions: Lower Urinary Tract Symptoms; Cystometry; Multiple Sclerosis; Overactive Bladder; Overactive Detrusor

Summary: this study evaluates the reproductibility (quantitative and qualitative) of cystometry in mutiple sclerosis patients.

some studies have evaluated the reproductibility of urodynamics in women with stress incontinence, and demonstrated a poor reproductibility of urodynamic parameters for a part of the studies and a good reproductibility for the others. there is only three studies investigating the reproductibility of repeated cystometries in patients with overactive detrusor and neurogenic lower tract dysfunction. the most common etiology in these studies is spinal cord injury. only one article includes ms patients with lower urinary tract symptoms (22 patients among 226 with other etiologies). the aim of this study was to assess the short term reproductibility in multiple sclerosis patients with qualitative and quantitative urodynamic data. the authors conducted a prospective analysis in our neuro-urology department of a university hospital . all patient with multiple sclerosis referred for urinary disorders, coming for a urodynamic evaluation with multiple cystometries during the study were included if they had a detrusor overactivity for a filling of 300 ml or less on the first cystometry. the main exclusion criteria were a significate difference between the filling volume during the study and the volume truly of water truly collected after catheterization, an urinary tract infection, or an other acute disease.the investigators performed a first cystometry and looked for a detrusor overactivity, if the investigators discovered an involuntary detrusor contraction for a filling of 300 ml or less, the authors realized two others cystometries (filling rate of 50 ml/min) after informed consent. the volume and pressure at which the first and the maximal involuntary detrusor contraction, mcc were documented.

Eligibility criteria:
inclusion criteria: * all patient with multiple sclerosis referred for urinary disorders, * coming for a urodynamic evaluation with multiple cystometries during the study - detrusor overactivity for a filling of 300 ml or less on the first cystometry. exclusion criteria: * significate difference between the filling volume during the study and the volume truly of water truly collected after catheterization, * an urinary tract infection, * an other acute disease.

Keywords: overactive detrusor multiple sclerosis reproductibility cystometry
oral immunotherapy for peanut allergy (pmit)

Conditions: Food Hypersensitivity

Summary: the purpose of this study is to determine if mucosal peanut immunotherapy will make subjects who have peanut allergy less allergic and induce changes in their immune system.

peanut allergy is known to cause severe anaphylactic reactions. compared with other food allergies it tends to be more persistent and also its prevalence seems to be rising. currently there is no proven treatment other than strict avoidance. we are attempting to decrease the risk of anaphylaxis on accidental ingestion by desensitizing subjects to peanut using peanut oral mucosal immunotherapy (oit). we are also studying the effect of peanut oit on the peanut specific immune response to determine if tolerance to peanut protein will develop. children ages 1 to 18 with peanut allergy will be randomized to peanut oit or placebo. subjects will undergo a modified rush immunotherapy on the first day and then increase the doses at least every two weeks up to a maintenance dose of 4 grams (equivalent to about 13 peanuts). doses will be taken daily at home except for dose increases which will be done on the research unit. subjects will undergo a double-blind, placebo-controlled food challenge (dbpcfc) after 12 months and then be unblinded. placebo subjects will cross over to open-label peanut oit and undergo an identical buildup schedule up to 12 months. all subjects will then complete at least 36 months of peanut oit therapy after which once skin prick (\<5 mm) and ige (\<15 ku/l) criteria are met, they will then complete the end of study dbpcfc. dosing will continue up to a maximum of 60 months after which even if criteria are not met, the subject will undergo the end of study dbpcfc. outcome variables of interest include response to dbpcfc, skin prick testing, peanut specific ige, and adverse events. these results will be compared between the start and end of peanut oit using appropriate statistical analysis.

Eligibility criteria:
inclusion criteria: * subject between 1 and 18 years of age * either history of significant clinical symptoms occurring within 60 minutes after ingesting peanuts greater than 6 months ago and peanut specific ige \>15 ku/l * or history of significant clinical symptoms occurring within 60 minutes after ingesting peanuts within the past 6 months and peanut specific ige \> 7 ku/l * a family that will be able to be compliant with all study visits * all females of child bearing age must be using appropriate birth control exclusion criteria: * subjects with a history of severe, anaphylaxis to peanut * medical history that would prevent a double blind placebo controlled oral food challenge (dbpcfc/ofc) to peanut * unable to cooperate with challenge procedures or unable to be reached by telephone for follow-up * diagnosed oat allergy * pregnancy or lactation

Keywords: peanut allergy
study of infantile lower limb malformations and deformities

Conditions: Deformity of Limb

Summary: the skeletal defects of the lower limbs in pediatric age encompass various congenital and acquired conditions that alter bone structure. these alterations can be symmetrical or asymmetrical, with potential consequences such as deformities, short stature, and disability. these condictions may impact not only on the physical and the mental function of the children, but also on their family context. management often requires a multidisciplinary approach for early diagnosis and treatment. deformities are heterogeneous and necessitate a personalized therapeutic plan. currently, in pediatric orthopedic surgery there is a lack of an instrument capable of evaluating all these aspects. the advancement of computer-assisted surgery and artificial intelligence could improve treatment customization and involve patients and families in therapeutic decision-making to prevent complications. this study aims to provide support for clinical practice to promote a systematic, comprehensive, and sequential evaluation of lower limb deformities in developmental age, from which epidemiological data and evidence on treatment approaches used in major referral centers can be extrapolated.


Eligibility criteria:
inclusion criteria: * age \< 18 years at the time of initial orthopedic evaluation * diagnosis of congenital or acquired musculoskeletal deformity to one or both lower limbs * presence of informed consent to participate in the study exclusion criteria: * refuse to participate in the study by the patient or parent/legal guardian * patients with mild paramorphisms not associated with functional limitations

Keywords: pediatric orthopedics deformity patient reported outcomes
improving the safety of oral immunotherapy for cow's milk allergy

Conditions: Food Allergy

Summary: allergy to cow's milk is the most common food allergy affecting children. there is currently no accepted routine clinical therapy to cure milk allergy. recently studies have attempted to induce desensitisation using small daily doses of cow's milk, predominantly by the oral route (oral immunotherapy, oit). although this therapy works for some people, its effects are not generally long lasting and it is associated with significant side effects during protocol, including potentially life-threatening allergic reactions. pilot data suggests that sublingual immunotherapy (slit, where allergen is held under the tongue, rather than swallowed) can also induce a degree of desensitisation, but with fewer adverse events. however, the degree of desensitisation induced appears to be lower than that with oral immunotherapy. the investigators wish to determine whether a sublingual pretreatment phase can improve the safety of conventional oit in cow's milk allergy.


Eligibility criteria:
inclusion criteria: 1. allergic to 1.44g cm protein (approx. 40ml fresh milk) or less, at dbpcfc prior to randomisation 2. informed consent of parent/legal guardian, patient assent where possible exclusion criteria: 1. required previous admission to an intensive care unit for management of an allergic reaction. 2. significant symptoms of non---ige---mediated cm allergy within the previous 12 months. 3. children with a past history of cm allergy currently consuming cm-containing products other than extensively--heated milk in baked foods (e.g. biscuits, cakes). 4. poorly controlled asthma within the previous 3 months (as defined by clinician judgement with reference to the icon consensus), or asthma requiring treatment with \>5 days oral corticosteroids within the previous 3 months. 5. moderate---severe eczema, defined as requiring more than once daily application of 1% hydrocortisone as maintenance treatment despite appropriate use of emollients (eczema is not otherwise an exclusion criteria) 6. clinically significant chronic illness (other than asthma, rhinitis or eczema) 7. history of symptoms of eosinophilic oesophagitis, irrespective of cause 8. undergoing specific immunotherapy to another allergen and within the first year of treatment. 9. receiving anti--ige therapy, oral immunosuppressants, beta---blocker or ace inhibitor. 10. pregnancy 11. unwilling or unable to fulfil study requirements

Keywords: cow's milk allergy desensitisation safety
cb1r in synthetic psychoactive cannabinoids

Conditions: Drug Dependence

Summary: the purpose of this research study is to determine whether the cb1r availability is lower in synthetic psychoactive cannabinoid subjects using the most widely available synthetic psychoactive cannabinoids at the time the study is initiated.


Eligibility criteria:
inclusion: * able to provide written consent * age 18-55 * current synthetic psychoactive cannabinoids consumption exclusion: * mri metal exclusions and claustrophobia * education completed is less than 12 years

Keywords: k2 spice synthetic marijuana
electrical stimulation to accelerate wound healing

Conditions: Diabetes; Diabetic Foot Ulcer; Peripheral Neuropathy; Peripheral Arterial Disease

Summary: a clinical study at the baylor college of medicine, division of vascular surgery and endovascular therapy, is being proposed to test the efficacy of a novel electrical stimulation platform named the tennant biomodulator designed by avazzia to accelerate wound healing, relieve pain and improve mobility in patients with diabetic foot ulcers.

electrical stimulation may offer a unique treatment option to heal complicated and recalcitrant wounds, improve flap and graft survival, and even reduce the likelihood of ulceration. electrical stimulation has been suggested to reduce infection, improve cellular immunity, increase perfusion, relieve pain, improve plantar sensation, and accelerate wound healing. electrical stimulation could have positive effect on not only increasing skin perfusion in patients with diabetes but also could improve mobility and balance via enhancing plantar sensation as demonstrated in our recent study. thus, plantar stimulation not only may be beneficial to accelerate wound healing in diabetic foot ulcer (dfu) patients but also may assist to improve mobility and reduce the likelihood of recurrence of ulcers. this study is proposed to examine the effectiveness of an innovative portable electrical stimulation platform (tennant biomodulator by avazzia) to accelerate wound healing in dfu patients. it is hypothesized that 1) electrical stimulation will have an immediate effect on increasing skin perfusion (immediate benefit) and 2) daily use of the tennant biomodulator for 4 consecutive weeks is effective to speed up wound healing, increase skin perfusion, reduce pain, and improve balance and mobility in dfu patients (long term benefit)

Eligibility criteria:
inclusion criteria: * able to provide informed consent * 18-85 years old * clinically confirmed diabetes (ada criteria) * clinically confirmed peripheral neuropathy * one or more active non-infected ulcers * subject or responsible caregiver is willing and to maintain the required offloading (as applicable the location of the ulcer) and applicable dressing changes and electrical stimulation application. exclusion criteria: * subject has a demand-type cardiac pacemaker, implanted defibrillator or other implanted electronic device * is pregnant * is nursing or actively lactating * has renal disease * active wound infection * active charcot foot * non-ambulatory (unable to walk 40 feet with or without assistive device) * bilateral ak/bk amputation * active drug/alcohol abuse * dementia or impaired cognitive function * excessive lymphedema * osteomyelitis and/or gangrene * unable to comply with research appointments (e.g. long travel) wide spread malignancy or systemically imumno-compromising disease * subject has a history of or any intercurrent illnesses or conditions that would compromise the safety of the subject according to judgement of a qualified wound specialist.

Keywords: electrical stimulation wound healing skin perfusion home based therapy diabetic foot foot ulcer
an epidemiological investigation on correct wearing of mask by direct spray test

Conditions: Respiratory Infectious Diseases

Summary: the purpose of this study was to explore the relationship between the transmission of respiratory diseases and the correct wearing of masks, as well as the factors affecting the correct wearing of masks. the research is beneficial to the prevention of respiratory diseases and moves the barrier of prevention and control forward. it is of great significance to covid-19 's practical prevention and control.

1. overall design：this study uses the methods of cross-sectional survey and chance sampling. 2. sign the informed consent form. 3. investigation on the basic situation of personnel: the gender, age and education level of the subjects were analyzed as the factors influencing whether the mask was worn correctly or not. 4. investigation on the types of wearing masks： 1) the types of masks worn by the subjects were recorded as the basis of stratified statistics. 2) mask suitability testing： 1. visual inspection whether the mask is close to the face with obvious gaps. 2. breathing test are there any obvious gaps or whether the cotton around the mask is blown when the subject taking a deep breath. 3. spray test the ft-30 qualitative fitness test system of 3m company was used to test the suitability and correctness of wearing mask. in the spray test, all subjects underwent a sensitivity test to prove their ability to smell the bitterness of the reagent, sensitive subjects can participate in the direct spray test. in order to objectively reflect the overall situation of the subjects, it is necessary to cover many ages and educational levels of men and women.

Eligibility criteria:
inclusion criteria: 1. healthy people with autonomous behavior ability and language expression ability who are older than or equal to 7 years old, persons under the age of 18 need to obtain the consent of their legal guardians； 2. the subjects and / or their legal guardians have the ability to understand the contents of the study and to participate in all the research processes with the subjects； 3. people who volunteered to take part in the study； 4. there was no respiratory infection in nearly one month. exclusion criteria: 1. people with a history of allergies, including those who are allergic to pollen, dust mites, etc； 2. people with any history of drug allergy； 3. people who have participated in the experiment are not allowed to participate in this study for the second time; 4. pregnant women； 5. the healer after covid-19 's infection； 6. after questioning, it was found that the subjects were the factors that affected the study, such as dysosmia, or those who had decreased olfactory ability due to disease, or facial paralysis, which affected the judgment of the test； 7. those who are participating in clinical trials of other drugs / devices； 8. subjects with poor compliance or unwilling to cooperate with the operation as required； 9. the researchers believe that any other situation that may affect the evaluation of the study.
reiki application pain, fatigue and itching in hemodialysis patients

Conditions: Hemodialysis Complication

Summary: the research sample consisted of 74 individuals, including the intervention group (n=37) and the control group (n=37), who received hemodialysis treatment at sivas cumhuriyet university application and research hospital hemodialysis unit, sivas numune hospital hemodialysis unit and private onr dialysis center. the data of the study were collected using the patient description form, the patient clinical parameters form (some treatment data and laboratory results, measurement of pain intensity), visual analogue scale (vas), mcgill melzack pain questionnaire, piper fatigue scale, and 5-d itch scale. a total of 10 sessions of reiki were applied to the patients in the intervention group twice a week for 5 weeks, lasting 40-45 minutes during dialysis. no treatment was applied to the control group. the scales were administered to the individuals in the intervention and control groups three times in total.


Eligibility criteria:
inclusion criteria: * the research sample consisted of patients who had no difficulties in communicating and had no mental problems, who had undergone hemodialysis treatment for at least one year, who were 18 years of age or older and who agreed to participate in the study, who did not receive complementary alternative treatment for symptom management, and who experienced symptoms of fatigue, itching and pain. exclusion criteria: * those younger than 18 years of age, those receiving hemodialysis treatment for less than a year, those with communication difficulties, those with psychiatric problems, and those who wanted to leave the study were not included in the study.