Kornimate/medical-research-clean huggingface dataset:
compare swallowing kinematics and suprahyoid muscle activation among three different swallowing tasks

Conditions: Swallowing Disorder

Summary: the aim of this study is to swallowing kinematics and suprahyoid muscle activation among masako, mendelsohn maneuvers and new-designed mouth open swallowing maneuver

swallowing disorder can result in aspiration pneumonia, dehydration, malnutrition and even death. therefore, it is a condition that needs to be detected, prevented and/or treated at an early stage. in the rehabilitation process of swallowing disorders, many exercise approaches are used, as well as compensatory postures and maneuvers. in addition to creating compensation and increasing swallowing muscle strength, the maneuvers used also change the temporal parameters associated with swallowing, such as delay in the swallowing reflex and time to close the airway. mendelson maneuver and masako maneuver are the most commonly used swallowing maneuvers in swallowing rehabilitation. during the mendelson maneuver, the patient is asked to voluntarily hold larynx when larynx is elevated. masako maneuver is swallowing with tongue positioned between anterior teeth. mouth open swallowing maneuver is new-designed exercise. 10 mm wedge is comfortably positioned on the molar teeth and patient is asked to swallow in this way. we think that the explosive force that occurs more hyolaryngeal displacement than normal swallowing. therefore, the targets of all three exercises in the swallowing physiology is different. it is important to investigate the effects of all three exercises on swallowing physiology in order to determine a patient-specific rehabilitation program and develop new techniques.

Eligibility criteria:
inclusion criteria: * volunteering to participate in the study, * getting less than 3 points from the t-eat-10 (turkish eating evaluation questionnaire) questionnaire exclusion criteria: * having disc herniation, mechanical neck pain or any pathology in the cervical region. * having a temporamandibular joint problem that may affect joint biomechanics and muscle functions. * having any neurological or systemic disease, * having undergone head and neck surgery or received radiotherapy.
self-expandable esophageal radiation stent:a randomized controlled trial in patients with advanced esophageal cancer

Conditions: Esophageal Cancer

Summary: to determine the response to treatment with a novel esophageal stent loaded with 125i seeds for intraluminal brachytherapy versus a conventional covered stent in patients with advanced esophageal cancer.

esophageal cancer is common in some areas , ranking as the fourth leading cause of death from cancer in china and sixth worldwide. although the prognosis of surgical resection for esophageal cancer has been improved, more than 50% of such patients are inoperable and have to undergo palliative treatments because of late stage cancer or metastasis. dysphagia is the predominate symptom of patients with inoperable esophageal cancer. to relieve the dysphagia and improve the quality of life of such patients, brachytherapy has previously been utilized. recently, stent placement has been widely accepted to be an option for palliation of the symptoms due to the esophageal strictures. however, recurrence of the neoplastic stricture remains a challenge after stent placement. to combine the advantages of the immediate relief of the esophageal dysphagia with the stent placement and radiation therapy with brachytherapy, a novel esophageal stent loaded with 125i seeds has been developed in the authors' institute. the technical feasibility and safety with this new stent has been demonstrated to be adequate in a healthy rabbit model. the current study is designed to demonstrate the preliminary results with this irradiation stent in patients with inoperable esophageal cancer compared to those using a conventional covered stent.

Eligibility criteria:
inclusion criteria: * histologically confirmed primary cancer of esophagus, * must be dysphagia caused by esophageal cancer, * surgically inoperable, but may be metastatic, * without esophageal fistulas, * must be an inpatient at zhongda hospital, * life expectancy is over 6 months, exclusion criteria: * esophageal fistulas, * tracheal compression with symptoms, * wbc \<2000/mm3 and platelet count \<50,000/mm3, * concurrent therapies:surgery, chemotherapy,radiotherapy, traditional chinese medicine

Keywords: esophageal cancer dysphagia stent interstitial brachytherapy
inner and middle ear effects of hyperbaric oxygen thrapy

Conditions: Otitic Barotrauma

Summary: audiological evaluation performed to patients on hyperbaric oxygen therapy to see its effects on middle ear pressure

thirty patients will be recruited from center pf hyperbaric oxygen therapy every patient who received hbot was submitted for demographic data:age,gender,condition raquiring hbot,use of analgesics,history of diabets ,cardiovascular or respiratory disease ,psychatric illness,smoking history facial/ent problems and previous hbot problems then tympanometry and basic pure tone audiometry including air and bone conduction is done following each of the first five treatment

Eligibility criteria:
inclusion criteria: * patients above 18 years old already recieving hyperbaric oxygen therapy for treatment of other medical conditions required treatment by it as in diabetic foot exclusion criteria: * patients who already had tympanostomy tubes
a study of conventional 3d radiation vs. intensity-modulated radiation in squamous cell cancer of the head and neck

Conditions: Head and Neck Neoplasms; Squamous Cell Cancer

Summary: this is a randomized study of conventional 3d radiation versus intensity-modulated radiation in squamous cell cancer of the head and neck.


Eligibility criteria:
inclusion criteria: * histologically proven squamous cell carcinoma of the head and neck or squamous cell cancer to the neck from an unknown head and neck primary site, stage i-iv disease which is m0, age greater than 18 years, kps greater than 70, signed study-specific consent exclusion criteria: * m1; bilateral n3 disease; primary greater than 10cm; salivary gland disease; life expectancy less than 2 years; prior radiotherapy to the head and neck; no signed study-specific consent form

Keywords: head and neck neoplasms squamous cell cancer intensity modulated radiotherapy
food effect on the eradication rate of h. pylori with triple therapy with esomeprazole

Conditions: Helicobacter Pylori Infection

Summary: the purpose of the study is assess whether the various forms of triple regimen of administration of treatment of helicobacter pylori (before meals (fasting), after meals, and any independent mealtime) influence the rate of eradication of this bacterium.

phase iv, open, randomized, prospective study. * length of experience: 180 days. * 06 visits. * evaluation of the efficacy of differences regimens of administration.

Eligibility criteria:
inclusion criteria: * participants of both sexes; * age greater than or equal to 18 and less than or equal to 50 years; * participant diagnosed with type dyspepsia epigastric pain carriers of helicobacter pylori infection, according to the classification of rome iii; * ability to understand and consent to participate in this clinical study, manifested by reading, understanding and signing of the informed consent (ic). exclusion criteria: * any finding of clinical observation (clinical evaluation / physical) that is interpreted by the investigator as a medical risk to participate in the clinical trial; * any laboratory examination found that the investigator doctor considers a risk to the research participant for their participation in the clinical trial; * known hypersensitivity to the drug components used during the study; * women in pregnancy or breastfeeding period; * women in reproductive age who do not agree to use acceptable methods of contraception (oral contraceptives, injectable contraceptive, iud, hormonal implants, barrier methods, abstinence, hormonal patch and tubal ligation); except surgically sterile (bilateral oophorectomy or hysterectomy); * participating in the research that has participated in clinical trial protocols in the last twelve (12) months (cns resolution 251 of august 7, 1997, part iii, sub-item j), unless the investigator considers that there may be direct benefit to it; * party that has some kinship to the second degree or bond with employees or employees of sponsor and research center; * patients with predominant symptoms of reflux or irritable bowel syndrome, warning symptoms, peptic ulcer history or previous surgery in the upper segment of the gastrointestinal tract; * patients with prior treatment history of eradication of helicobacter pylori; * patients with kidney, liver or heart failure; * patients with past or current history of alcohol abuse; * patients with a history of use of antibiotics or bismuth in the 4 weeks prior to study entry, ppis or h2 blockers, nsaids or aspirin in the last two weeks; * patients whose endoscopy show changes except hyperemic gastritis, erosive gastritis den considering the maximum of 5 erosions in this location or hiatal hernia; * patients whose ultrasonography show hepato-biliopancreatic changes except steatosis.
vr training for pilots with neck pain

Conditions: Neck Pain; Cervical Pain

Summary: the aim of the proposed study is to investigate the effectiveness of an interactive, virtual reality (vr) training program for pilots compared with standard care. the study will be a randomized controlled trial (rct) consisting of 60 pilots randomized into one of two groups: standard physiotherapy and medical care vs standard care and vr training. outcome measures will include subjective scores of pain intensity and global perceived effect; objective measures of range of motion (rom), neck motion velocity, and motion accuracy; and functional measure of days grounded due to neck pain. data will be analyzed using anova for within and between groups analyses.

the aim of the proposed study is to investigate the effectiveness of an interactive, virtual reality (vr) training program for pilots compared with standard care. the proposed intervention program includes training in neck range of motion, control, accuracy and coordination and is expected to reduce the prevalence and operational impact of neck pain in the intervention group more effectively than does standard care alone. the proposed study will be designed as a randomized, controlled trial (rct). sixty fighter and helicopter pilots will be randomized into two groups, to receive either standard physiotherapy and medical care or standard care with the addition of interactive, dynamic, controlled training (a self-exercise program) in vr to address the fast, accurate head control required in flying tasks. subjective outcome measures will include pain intensity and global perceived effect. objective measures will include range of motion, motion velocity and accuracy. the functional measure will include days grounded due to neck pain. statistical analysis will use independent, repeated measures anova on each parameter, within and between groups. post hoc comparisons, including several preplanned contrasts, will be performed to assess differences before and after treatment, and the stability of changes over time, in each group. the relationship of risk factors to performance failures will be assessed using multivariate logistic regression analyses. this study is the first in the israeli air force to evaluate this type of comprehensive, functional intervention program. such research will dramatically advance the military's health care approach to neck pain, and may be further applied to other populations in and outside the israeli defence force (idf). this study may serve as a stepping stone to further research related to diagnosis, treatment, and prevention methods during a pilot's active service.

Eligibility criteria:
inclusion criteria: * fighter and helicopter pilots from the israeli air force * acute, sub-acute, and chronic neck pain, with or without referral to the upper limbs exclusion criteria: * neurological disorders (e.g. evidence for positive neurological signs), systemic disease, history of spinal surgery, or any disorders that may limit the ability to exercise

Keywords: neck pain virtual reality range of motion physiotherapy air force kinematics
diabetes telemedicine consultation: a systems improvement intervention

Conditions: Diabetes Mellitus Type 2; Diabetes Mellitus, Type 1; Primary Care Provider

Summary: this study seeks to evaluate and document the processes of outreach consultation through joint-clinics via teleconferencing as an intervention for system improvement in care delivery and management of diabetes mellitus (dm) at a community based outpatient center (cbocs).

background: diabetes is a national problem that has reached epidemic proportions, according to the u.s. centers for disease control and prevention. diabetes has particular importance for the department of veterans affairs (va) because the prevalence among va patients -- one in six, or 16 percent -- is substantially higher than in the general population. objectives: the objective of this study was to evaluate and document the processes of outreach consultation through the use of joint-clinics via teleconferencing as an intervention for system improvement in care delivery and management of diabetes at cbocs. the intervention consisted of a teleconferenced joint-clinic consultation session involving the patient, diabetes specialist team, the primary care provider (pcp) and other relevant care team members. the impact of the 16-month intervention was assessed based on patients who were involved in the telemedicine clinic and those who were referred to a specialist to be seen on-site at the cleveland vamc. methods: study settings include the cbocs affiliated with the cleveland veterans affairs medical center (vamc) and involve primary care referrals to see diabetes specialists at the cleveland vamc. inclusion criteria patients(n 282)=included: (i) current prescription of insulin or an oral hypoglycemic agent; (ii) a1c \> 7.0%; or (iii) fasting glucose levels\> 130 mg/dl; and (iv) referred to see a consultant (beginning three months prior to the active intervention phase and continuing through enrollment for the last month of the active intervention phase). patients with either type l or type ii diabetes will be included. patients referred will be contacted and asked to participate.

Eligibility criteria:
inclusion criteria: * 1) current prescription of insulin or an oral hypoglycemic agent * 2) a1c \> 7.0% * 3) fasting glucose levels \> 130 mg/dl * 4) referred to see a consultant and are seen during the active intervention phase. patients with either type i or type ii dm will be included a primary care provider for a cleveland cboc exclusion criteria: * 1) primary care obtained at more than one site (based on stop codes with evidence of more than 1 cboc involved in care during the last 6 months) * 2) documented dementia, aphasia, and psychosis

Keywords: diabetes mellitus telemedicine referral consultation
outcome following antidepressant treatment on possible endo-phenotypes for major depression

Conditions: Healthy

Summary: the purpose of this study is to determine whether outcome following antidepressant treatment can be used as a tool to evaluate endo-phenotypes for depression.

the research in depression has for some years focused at the identification of endo-phenotypes. endo-phenotypes are heritable biological or psychological markers, which are more commonly found in patients and their healthy relatives than in the general population. recent studies point at disturbed regulation of the hypothalamic-pituitary-adrenocortical (hpa) system as a possible endo-phenotype for depression. the hypothesis of agenda are that endo-phenotypes are affected by treatment with antidepressants in healthy first degree relatives. agenda is a four week randomized, placebo-controlled, double-blind trial in which first degree relatives of patients with the diagnosis of depression are randomised in to two groups, which are treated with either placebo or antidepressant medicine (cipralex). we expect to include 80 healthy subjects, with the predisposition for depression, since one of their parents or siblings recently was treated for depression. the subjects will be examined before and after four weeks of treatment by a thorough interview concerning psychiatric symptoms (scan), including depressive symptoms, personality, perceived stress and cognitive function. the effect of antidepressant on stress is measured with saliva-cortisol and by the response to the combined dexamethasone corticotropin-releasing (crh) hormone test. additionally, mr and pet scans of the 5-ht4 receptor function will be conducted before and after 4 weeks of treatment.

Eligibility criteria:
inclusion criteria: * offsprings or siblings of patients with major depression * born in denmark with european parents and grandparents * for women; not pregnant or breastfeeding * written informed consent exclusion criteria: * somatically illness or other handicaps which make participation in the study impossible * daily intake of drugs interfering with corticosteroids or escitalopram * hypersensitivity to escitalopram, dexamethasone or human corticotropin-releasing hormone * former medical or psychological treatment for diseases in the affective or schizophrenic spectrum * ongoing addiction of alcohol or psychoactive drugs

Keywords: major depression first degree relatives escitalopram cortisol cognition personality endo-phenotype
dm199 for pregnancy complications

Conditions: Pre-Eclampsia

Summary: this entry was submitted in error by diamedica therapeutics, inc. and was not authorized by any of the trial investigators or study sponsor (stellenbosch university). the clinical trial, dm199 for pregnancy complications, was prospectively registered with the pan african clinical trials registry (pactr202404895013782), in accordance with icmje and who requirements. this listing serves as the primary and authoritative registration record for this investigator-initiated study.


Eligibility criteria:
please refer to the pan african clinical trials registry (pactr202404895013782).
lifestyle management for women with chd and niddm

Conditions: Cardiovascular Diseases; Coronary Disease; Heart Diseases; Diabetes Mellitus, Non-insulin Dependent; Postmenopause; Diabetes Mellitus

Summary: to develop and evaluate a comprehensive lifestyle self-management (clsm) program (low-fat vegetarian diet, smoking cessation and stress management training) for postmenopausal women with coronary heart disease and type ii (non-insulin dependent) diabetes.

background: coronary heart disease is the leading cause of death among postmenopausal women. yet few studies have examined the potential for altering risk factors for coronary heart diseases among postmenopausal women, especially as a result of comprehensive lifestyle changes. a pressing need existed for controlled studies to evaluate the effects of comprehensive lifestyle changes on risks for coronary heart disease among postmenopausal women. design narrative: the comprehensive lifestyle management program appeared to produce substantial cardiovascular benefits among men but little was known about the behavioral processes through which change occurred. its generalizability and applicability -- especially for high-risk women --was uncertain. the program was compared to a usual care condition in an initial randomized trial. outcome measures included patient self-care behaviors and health outcomes (serum lipid profiles, blood pressure, relative weight, and glycemic control). process measures included self-efficacy, personal health models, perceived stress, social support and problem-solving skills. subjects participated in the intervention for three years, with gradual fading of the program in the third year to evaluate the long-term effects of the program. analyses included assessments of between groups differences on physiological risk factors, behavioral (lifestyle) measures and process measures as well as maintenance over time. based upon the results of this study, the long-term goal was to design a second outcome study in which the revised intervention would be evaluated with a larger sample to determine the relative contribution of adding moderate exercise and the effects on reversal of coronary heart disease.

Eligibility criteria:
no eligibility criteria
aliskiren study of safety and efficacy in senior hypertensives

Conditions: Hypertension

Summary: this study is designed to compare the blood pressure lowering efficacy of aliskiren, a combination of aliskiren plus amlodipine, and ramipril in elderly patients with mild to moderate hypertension. it will also compare the long-term safety of an aliskiren-based regimen to a ramipril-based regimen


Eligibility criteria:
inclusion criteria: * patients ≥ 65 years of age with a clinical diagnosis of essential hypertension at visit 1. * mean sitting sbp (mssbp) ≥ 140 mmhg and \< 180 mmhg at visit 2/visit 201 and visit 3. * absolute mssbp difference ≤ 20 mmhg between visit 3 and the visit immediately prior exclusion criteria: * history of hypersensitivity to any of the study drugs or to drugs of similar chemical classes. * severe hypertension (mssbp ≥ 180 mmhg or msdbp ≥ 110 mmhg) at visit 1, visit 2, visit 201 or visit 3 or during patient self measured blood pressure (smbp) monitoring in the pre-randomization period confirmed by office measurement. * current treatment with any blocker of the renin angiotensin aldosterone system (raas) (aliskiren, ace inhibitor, angiotensin receptor blocker or an aldosterone antagonist) and unable to discontinue this therapy. * concurrent use of any anti-hypertensive medications except a stable dose of 3 months prior to visit 1 of alpha adrenergic blockers for benign prostatic hypertrophy (e.g., tamsulosin \[flomax®\] for benign prostatic hypertrophy), beta blockers for angina, or beta blocker ophthalmic preparations. * contraindications to aliskiren, ramipril, amlodipine, or hydrochlorothiazide. other protocol defined inclusion/exclusion criteria apply

Keywords: high blood pressure, stage 1 and 2 hypertension
teleassessment in ataxic multiple sclerosis

Conditions: Ataxia; Multiple Sclerosis

Summary: our aim is to compare icars and sara scores with face-to-face and tele-assessment methods in ataxic multiple sclerosis patients. the hypotheses on which this study is based are; h1: tele-assessment and face-to-face assessment results of the icars differ in patients with ataxic ms. h2: tele-assessment and face-to-face assessment results of sara differ in patients with ataxic ms.

patients will be evaluated both face-to-face and via tele-assessment (video conference call). in these evaluations, icars and sara will be used. face-to-face and tele-assessments will be applied on the same day, the order of administration will be decided by the randomization method, and a 10-minute rest will be given between the assessments.the interview will be recorded during the tele-assessment and a re-assessment will be made on the same recording 1 week later. face-to-face assessment will be done as routinely done in the clinic. face-to-face and tele-assessments will be made by 3 different assessors. assessors will be blind to each other's assessment. all assessments will be carried out at hacettepe university faculty of physical therapy and rehabilitation.

Eligibility criteria:
inclusion criteria: * be between the ages of 18-50 years * being diagnosed with ms by a neurologist * expanded disability status scale (edss) score between 3-5 * edss pyramidal system score ≤ 3 and cerebellar functional system score ≥ 1 * being clinically stable for the last 3 months * agree to participate in the study exclusion criteria: * having other systemic, orthopedic or neurological disease * having a history of attacks in the last 3 months * having peripheral vestibular complaints * being mentally affected (montreal cognitive rating scale score \< 21) * severe spasticity (modified ashworth scale \> 3)