Kornimate/medical-research-clean huggingface dataset:
long term maintenance of drug abstinence

Conditions: Cocaine Dependence; Cocaine Abuse

Summary: the purpose of this study is to develop a model for long-term maintenance of behavior change by examining the effects of extending the duration of contingency management (cm) for drug abuse on long-term abstinence outcomes. the primary hypothesis is that the extended (36 week) cm group will have better long-term outcomes as exhibited by greater rates of abstinence at each follow-up assessment as compared to the standard (12 week) cm group.

this protocol examines the effects of extending the duration of contingency management (cm) for drug abuse and dependence on long-term abstinence outcomes. following the tenets of basic behavioral research, we have outlined a model for long-term behavior maintenance that suggests that successful long-term behavior change does not focus on undoing old behaviors, but concentrates on developing new behaviors in a wide variety of new contexts, and provides enduring reinforcement for the new behaviors. the implication of this model is that in order to develop strategies for supporting long-term behavior change we need to determine the optimal duration of continuing treatment-arranged contingencies, better specify incompatible behaviors that emerge for patients who are successful in sustaining periods of continuous drug abstinence, and determine which incompatible behaviors are most likely to have naturally-occurring sustaining contingencies of reinforcement. this research will examine the model by randomly assigning cocaine-dependent or cocaine-abusing methadone maintenance patients to either a standard (12 week) or extended (36 week) period of contrived contingencies. we will be conducting a 2 year follow-up in order to investigate whether providing a longer duration of cm will result in a greater proportion of abstinent individuals during this time, how long the abstinence will last and to discover if longer durations of drug abstinence during the first year after treatment entry will predict better longer-term abstinence outcomes. we also compare outcomes on abstinence-related behaviors to see if provision of an extended voucher program leads to an increase in non-drug using natural reinforcers and activities. this study participates in the nih-sponsored health maintenance consortium designed to promote interchange of concepts, methods and measures related to the maintenance of long-term behavior change.

Eligibility criteria:
inclusion criteria: * meet dsm-iv criteria for current cocaine dependence or abuse * be willing and able to give valid contact information * be receiving a stable dose of 40 milligrams or more of methadone exclusion criteria: * are unable to give informed consent (fails simple open-ended consent quiz) * answer yes to the question "are you in recovery from gambling? that is, have you stopped gambling because of previous problems with gambling?" * report that they have a romantic partner who is already participating in the study

Keywords: cocaine dependence cocaine abuse substance abuse contingency management drug treatment
trial to evaluate reduction in inflammation in patients with advanced chronic renal disease utilizing antibody mediated il-6 inhibition

Conditions: Chronic Kidney Diseases; Inflammation

Summary: patients with chronic kidney disease, who have evidence of systemic inflammation with increased cardiovascular risk, will be enrolled into this trial. the purpose of this trial is to determine a dose to select for a potential cardiovascular outcome trial with ziltivekimab. doses to be tested will be 7.5 mg, 15 mg and 30 mg subcutaneous monthly compared to placebo for six months.


Eligibility criteria:
inclusion criteria: * 18 years of age * stage 3-5 ckd * hs-crp \> 2.0 mg/l * comply with contraception exclusion criteria: * low neutrophil count * low platelet count * spot urine protein to creatinine ration \> 4000 mg/g * alt/ast \>2.5x uln * tsat \< 10% * positive tb test * evidence of hiv, hepatitis b * blind or illiterate * expected to require blood transfusion * thromboembolic event within 12-weeks * evidence of active infection * peptic ulcer disease, diverticulitis, inflammatory bowel disease * uncontrolled hypertension * planned coronary revascularization * major cardiac surgery, chf * active malignancy, bone marrow or organ transplant * allergy to study drug * treatment with investigational drug, treatment with hif stabilizer or esa * use of immunosuppressive drugs, systemic antibiotics * breastfeeding, any other significant medical history

Keywords: il-6 crp chronic kidney disease cardiovascular disease inflammation
acupuncture for prevention and treatment of oral-related complications caused by radiotherapy for head and neck cancer

Conditions: Malignant Tumor of Head and/or Neck; Radiotherapy; Complications

Summary: a study on the efficacy and safety of acupuncture for the prevention and treatment of oral-related complications caused by radiotherapy for head and neck malignant tumors

the goal of this clinical trial is to investigate the efficacy and safety of acupuncture for oral-related complications in patients with head and neck malignant tumors who receive radiotherapy. the main questions it aims to answer are: * the efficacy of acupuncture for the prevention and treatment of oral-related complications caused by radiotherapy for head and neck malignant tumors * the safety of acupuncture for the prevention and treatment of oral-related complications caused by radiotherapy for head and neck malignant tumors participants will: * be treated with real acupuncture or sham acupuncture * be evaluated to learn the efficacy and safety of acupuncture for the prevention and treatment of oral-related complications caused by radiotherapy for head and neck malignant tumors researchers will compare real acupuncture group with sham acupuncture group to see if acupuncture has good efficacy and safety of acupuncture for the prevention and treatment of oral-related complications caused by radiotherapy for head and neck malignant tumors.

Eligibility criteria:
inclusion criteria: * patients diagnosed with malignant tumors of the head and neck without metastasis * age ≥18, ≤80 years old * zps score ≤2 * receiving radiotherapy alone or concurrent radiotherapy with a radiation dose of \>50 gy, including at least one parotid gland * judged to be able to receive acupuncture treatment, with all needle positions identified as accessible * signed informed consent form exclusion criteria: * history of dry mouth, sjogren's syndrome, or other underlying systemic condition known to cause dry mouth * suspected or confirmed physical closure of both salivary gland ducts * have a phobia of needles or prohibit the use of acupuncture at any acupuncture points * have a history of head and neck radiotherapy * have contraindications to acupuncture, including but not limited to bleeding disorders, having skin infections, ulcers or frequent infections * have taken any medications or herbs within the past 30 days that may affect salivary function, plan to or eventually take such substances during the study period * poor oral hygiene or severe periodontitis * poor compliance * other patients who, in the opinion of the investigator, are not suitable for participation in this study
evaluation of an educational program associated with exercises (edex) before total knee arthroplasty

Conditions: Knee Osteoarthritis

Summary: the purpose of this study is to determine whether a standardized education and exercise program proposed before a total knee replacement for knee osteoarthritis is effective in functional recovery after surgery.

knee osteoarthritis leads to deficiencies in muscle strength, knee range of motion and balance, and cardio respiratory deconditioning that contribute to alter abilities to perform activities of daily living. it is the principal indication for total knee arthroplasty (tka). patients' functional state and pain level are generally improved after tka and the physical and functional status pre-tka are predictive of recovery after surgery. decreasing length of stay at surgery departments and promoting return at home after tka are recommended. the recommendations of the health authority in france (has) and the new law of finance for french clinics contribute to shorter hospital stays and to restrain the conditions of admission to physical medicine and rehabilitation department after tka.exercise and education programs conducted before tka could help better prepare patients for surgery, improve functional outcome and accelerate functional recovery after surgery thus reducing the length of stay in orthopedic departments and facilitate return to home (directly or after a stay in pmr departments). the type of program necessary to achieve those goals remains to be defined.a systematic review of the literature associated with an analysis of practices about the relevance of rehabilitation programs before tka, concluded that the implementation of such programs before tka was likely to reduce the length of stay in surgery departments and improve the rate of direct return to home after surgery but that high quality trials were lacking. it also suggested that association of exercise programs with educational ones could be more effective than exercise or education alone, particularly for fragile patients with impaired functional capacity, co-morbidities and/or social problems.

Eligibility criteria:
inclusion criteria: * male or female aged 50 to 85 years * patient suffering from knee osteoarthritis according to acr for which a total knee arthroplasty is scheduled * preliminary medical examination whose results will be transmitted to the patient * patient giving his informed consent to participate in the study * patient affiliated to or beneficiary of social insurance exclusion criteria: * patients institutionalized * patients who have already received an ipsilateral total knee arthroplasty * patients with chronic inflammatory arthritis * cognitive or behavioral disorders making assessment impossible * inability to speak and write french * tka indicated for other reason than osteoarthritis

Keywords: total knee arthroplasty total knee replacement knee osteoarthritis education exercise handicap function cost-effectiveness cost-utility quality of life
influence of hypoxic induced factors in patients with hereditary hemorrhagic telangiectasia

Conditions: Hereditary Hemorrhagic Telangiectasia

Summary: patients with hereditary hemorrhagic telangiectasia (hht) suffer from an inherited disorder leading to systemic vascular malformations. mutations in several genes of the transforming growth factor (tgf)-β superfamily pathway influence angiogenesis in patients with hht. the genetic loss of alk1 or eng alone are not sufficient to induce avms; environmental insults that could trigger angiogenesis (e.g. wounding) are also needed. in this study it will be analyzed if hypoxic induced factors could have an influence on the disease hht.

hereditary hemorrhagic telangiectasia (hht) is characterized by systemic vascular malformations leading to recurrent bleedings and shunt formation especially in the liver, lungs and the brain. the underlying pathogenic hht mechanism remains unclear. the wide variability in age of onset and severity of symptoms amongst patients, even within the same family, suggests several factors contribute to the complexity of this disease. mutations in several genes of the transforming growth factor (tgf)-β superfamily pathway influence angiogenesis in patients with hht. the genetic loss of alk1 or eng alone are not sufficient to induce avms; environmental insults that could trigger angiogenesis (e.g. wounding) are also needed. in this study it will be analyzed if hypoxic induced factors could have an influence on the disease hht.

Eligibility criteria:
inclusion criteria: * diagnosed hht (genetic testing and/ or fulfill at least 3 curacao criteria) * older than 17 years * ability to consent exclusion criteria: * if inclusion criteria are not met

Keywords: hereditary hemorrhagic telangiectasia
adverse events related to treatments used against coronavirus disease 2019

Conditions: Coronavirus; Iatrogenic Disease; Acute Kidney Injury; ARDS, Human

Summary: the outbreak of covid-19 started several clinical trials and treatment experiments all over the world in the first months of 2020. this study investigates reports of adverse events related to used molecules, including but not limited to protease inhibitors (lopinavir/ritonavir), chloroquine, azithromycin, remdesivir and interferon beta-1a. analyses of reports also include the international classification of disease icd-10 for treatments in the world health organization (who) global individual case safety report (icsr) database (vigibase).


Eligibility criteria:
inclusion criteria: * all patients treated for covid-19 exclusion criteria: * chronology not compatible between the drug and the toxicity
lifestyle, exercise and nutrition study 2 (lean 2)

Conditions: Breast Cancer; Weight Loss

Summary: the specific aims of this study are to determine the efficacy and cost-effectiveness of a weight loss program compared with usual care (control) treatment on 6-month changes in body weight, body fat, serum hormones, and breast tissue markers associated with prognosis in breast cancer survivors.

we will conduct a two-armed study comparing a combination of an in-person and telephone weight loss program compared to usual care/wait list in 100 breast cancer survivors. women will be randomized into one of the study arms using a random permuted block design. research staff collecting body composition data, as well as reviewing forms and entering data, will be blinded to the participant's study group.

Eligibility criteria:
inclusion criteria: * american joint committee on cancer (ajcc) stages 0-iiic breast cancer * bmi \>25 kg/m2 * completed surgery, chemotherapy and radiation at least 2 months ago * physically able to exercise * agrees to be randomly assigned to either weight loss or control * gives informed consent to participate in all study activities * able to come for baseline and 6-month clinic visits * mentally competent exclusion criteria: * patients with double mastectomy

Keywords: breast cancer survivorship weight loss
mpath for low-income older adults

Conditions: Sedentary Time; Insomnia; Cognitive Decline

Summary: although empirical research suggests that physical activity interventions benefit cognition and sleep in older adults in general, the possible benefit of physical activity is understudied in low-income older adults. the study aims to test the immediate and sustaining efficacy of an mhealth-facilitated physical activity toward health (mpath) intervention on cognitive function and sleep in low-income older adults.

low-income older adults (lioa) are a population at higher risk to develop alzheimer's disease and related dementias (adrd) and sleep disturbances. although empirical research suggests that physical activity interventions benefit cognition and sleep in older adults in general, the possible benefit of physical activity is understudied in lioa. the growing wearable device and mobile health (mhealth) provide an innovative approach to deliver individually tailored physical activity interventions at home with flexible schedules to overcome barriers to physical activity in lioa. in addition, limited research has examined if physical activity interventions impact the individual's amyloid/tau/ neurodegeneration (atn) alzheimer's disease biological state and whether physical activity may promote cognition through impacting sleep and ad pathology. this randomized controlled trial is designed to examine the immediate and sustaining efficacy of an mhealth-facilitated physical activity toward health (mpath) intervention on cognitive function and sleep in lioa. mpath is a personalized physical activity intervention that includes personalized physical activity plans and training sessions, exercise at home by following personalized exercise videos, and biweekly phone coaching over 24 weeks, supported by wearable devices-enabled mhealth strategies. mhealth strategies and exercise videos will be used to support participant's physical activity during 6-12months.

Eligibility criteria:
inclusion criteria: * self-reported difficulty of sleep * lack of physical activity/exercise * low household income * capacity for moderate intensity exercise exclusion criteria: * untreated sleep apnea * severe depression or anxiety * dementia * history of neurologic or psychiatric disorders, neurodevelopmental impairment, traumatic brain injury * current enrollment in another clinical trial

Keywords: physical activity memory sleep
allergology: information, data and knowledge organization

Conditions: Food Allergy; Peanut Allergy

Summary: digital technology is essential in the field of health, via connected objects, the medical internet or even telemedicine; and the info-communication practices (ways of getting information and communicating) of the actors go through digital devices. in addition, at present, the mass of activity documents to be managed in healthcare establishments and an abundant supply of documentary resources in health, available on the internet, lead to infobesity, information pollution, and work overload. these phenomena lead to an increase in the time spent searching for relevant information and even to the burnout of healthcare professionals. a contextualization of the information communication systems through which the practices of health professionals pass therefore seems necessary so that the tools for managing, extracting and organizing knowledge can support these actors in their work. in the field of allergies, there are many players, and the information that is useful to them is abundant and heterogeneous. this study is based on the hypothesis that a knowledge organization model, developed from existing practices, could make it possible to obtain satisfactory results when searching for information, and be integrated into the daily practices of actors by linking up with other already existing systems and tools.


Eligibility criteria:
inclusion criteria: * professionals from the allergy unit (doctors, interns, paramedics, study coordinators), in total around 20-30 people. * observations will be conducted during their team meetings and will not impact their workflow. * subjects publishing information on allergy on public web sites exclusion criteria: * professional not willing to participate to the research. * users publishing information on private web sites or forums.

Keywords: food allergy peanuts oral immunotherapy efficacy safety
single-use cystoscope system for direct visualization of the urethra and bladder

Conditions: Cystoscope; Bladder Cancer; Lower Urinary Tract Symptoms

Summary: in this study, the new ascope 4 cysto is used to see how well it visualizes the lower urinary tract, and if this new flexible cystoscope performs as well as other routinely used cystoscopes. this study will be done in patients who have been diagnosed with bladder lesions and who will undergo surgery via the urethra to remove these lesions. the surgery is done under general anesthesia. after being brought under anesthesia and before removal of the lesion(s), the new flexible cystoscope is tested. the cystoscope will be used to visualize the urethra and bladder. data will be collected on the number of the lesions that can be seen using the new cystoscope. during the planned surgery a resectoscope or rigid cystoscope will be used to confirm the number of lesions. the data will be used to show how well the cystoscope visualizes the lesions in comparison with routinely used cystoscopes. it will give information on how well the structures of the urinary tract and bladder can be viewed including any abnormalities that are present.data will also be collected on the handling of the cystoscope: how well the cystoscope moves into the lower urinary tract, and how well it can be navigated through the lower urinary tract.

clinical phase: pre-ce study design: a non-randomized confirmatory study on the visualization performance of the ambu® ascope™ 4 cysto and aview™ urologia in 42 fully evaluable, adults subjects aimed at identification of known pathological findings (papillary bladder or small resectable lesion) detected with ambu® ascope™ 4 cysto and aview™ urologia and subsequently during a repeat procedure using a reusable rigid scope or resectoscope at the time of planned transurethral resection of bladder tumours (turbt). population: adult subjects (≥ 18 years) in the or undergoing planned transurethral resection of bladder tumors turbt planned sample size: a total of 42 patients will result in a maximum (if the true proportion is 50 %) width of the two-sided 95 % confidence interval for the binary variable "confirmed" to be 15%. this width is considered to be useful in the interpretations of the results from this investigation. study duration: screening, procedure and follow-up will take 15 days maximum follow-up duration: follow-up immediately after procedure investigational device: ambu® ascope™ 4 cysto and aview™ urologia pre-ce, single use cystoscope.

Eligibility criteria:
inclusion criteria: * willing to sign the informed consent * adults (males and females), ≥18 years of age or older * able to undergo routine cystoscopy * patients diagnosed with papillary bladder or small resectable lesion where transurethral resection of the tumour/lesion is planned exclusion criteria: * history of prior bladder/urethral reconstructive surgery * presence of symptomatic urinary tract infection (uti) * known unpassable urethral stricture * unable to read and/or understand the study requirements * pregnant or lactating women
a study of the safety and effectiveness of liquid certolizumab pegol in the treatment of signs and symptoms of rheumatoid arthritis and in prevention of joint damage in patients with active rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: an open ended study in which patients who completed the preceding double-blind study nct00160602 are given certolizumab pegol and assessed for signs and symptoms of rheumatoid arthritis.


Eligibility criteria:
inclusion criteria: patients must have either failed to achieve an american college of rheumatology 20 % (acr20) response at weeks 12 and 14 in c87050 \[nct00160602\], or must have completed the entire week 24 assessment of c87050 \[nct00160602\] trial. exclusion criteria: * a diagnosis of any other inflammatory arthritis (e.g. psoriatic arthritis or ankylosing spondylitis) * a secondary, non-inflammatory type of arthritis (e.g. osteoarthritis or fibromyalgia) that in the investigator's opinion is symptomatic enough to interfere with evaluation of the effect of cdp870 on the patient's primary diagnosis of rheumatoid arthritis (ra) * any concomitant biological therapy * any experimental therapy, within or outside a clinical

Keywords: rheumatoid arthritis cdp870 certolizumab pegol cimzia