Kornimate/medical-research-clean huggingface dataset:
acute health effects of short-term use of e-cigarettes on pulmonary and cardiovascular system

Conditions: E-cigarette

Summary: the goal of our study was to assess acute, short term respiratory (airflow, feno, o2 saturation, exhaled air temperature) and cardiovascular (heart rate, blood pressure) responses to smoking an e-cigarette in exclusive e-smokers and dual users and to compare these effects with responses to smoking a tobacco-cigarette in exclusive tobacco smokers.


Eligibility criteria:
inclusion criteria: - smoking status (cigarette or e-cigarette smoking) exclusion criteria: * occurrence of any chronic diseases, * history of lung conditions (eg.: asthma or bronchial hyperactivity in childhood), * presence of any allergic diseases, * medication intake within the last 2 weeks, * acute illnesses or infections in the last 2 weeks, * influenza vaccination in the last 2 weeks, * or current pregnancy or lactation.

Keywords: e-cigarette health effects cigarette smoking exhaled nitric oxide pulmonary function tests
ergonomic risk assessment for musculoskeletal disorders in office workers turkish version, validity and reliability study

Conditions: Healthy

Summary: today, there is a relationship between the increase in the use of electronic devices such as smartphones or tablets and musculoskeletal disorders. different usage styles of various electronic devices such as laptops, smartphones and tablets affect the risk factors that may be related to musculoskeletal disorders in office workers. in addition to the use of electronic devices, the posture of the office worker's head, waist and hands while sitting are among the risk factors. parameters such as the features of the chair he is sitting on, the height and distance of the table affect the person's posture. evaluation of these factors is important in preventing musculoskeletal disorders. the ergonomic risk assessment for musculoskeletal disorders in office workers was developed by kluay-on et al. in 2022 and its validity and reliability were established. the aim of our study is to culturally adapt the ergonomic risk assessment for musculoskeletal disorders in office workers into turkish and to examine its validity and reliability.


Eligibility criteria:
inclusion criteria: * being an employee of tokat gaziosmanpaşa university * being an office worker exclusion criteria: * not being an office worker
comorbid insomnia and sleep apnea

Conditions: Obstructive Sleep Apnea; Insomnia

Summary: insomnia and osa coexist in clinical populations, but the prevalence of comorbid insomnia among osa patients in the community and risk factors remain poorly known. little is known about the impact of sleep apnea and insomnia on the quality of life and quality of sleep compared to the presence of one of the sleep disorders alone. our hypothesis is that the co-existence of osa and insomnia is high in our community. we also hypothesized that the co-existence of osa and insomnia promotes greater impairment of quality of life and quality of sleep when compared to the presence of osa or insomnia alone. patients referred to polysomnography will be submitted to 6 questionnaires to assess daytime sleepiness (epworth), insomnia severity index (isi), anxiety and depression assessment (beck's anxiety and depression inventory), quality of life assessment(whoqol- bref) and sleep quality assessment (pittsburgh questionnaire) and they will also be submitted to a polysomnography type iii. it will be calculated the frequency of insomnia, osa and the comorbidity between insomnia and osa in the sample. it will be analysed correlations between the insomnia severity index, apnea and hypopnea index, epworth sleepiness scale, quality of life scale (whoqol-bref), anxiety and depression scale (beck's anxiety and depression inventory) and pittsburgh sleep quality scale. insomnia severity index scores, epworth sleepiness scale, quality of life scale (whoqol-bref), anxiety and depression scale (beck anxiety and depression inventory) and pittsburgh sleep quality scale will be compared according to the presence and absence of osa and the presence and absence of insomnia and the presence of the comorbidity insomnia and osa.


Eligibility criteria:
inclusion criteria: -individuals who will participate in the task force for the diagnosis of sleep apnea promoted by the state department of health in an agreement signed with the heart institute exclusion criteria: * individuals under 18 years old
follow-up of the epitope study to evaluate long-term efficacy and safety of dbv712 in young children

Conditions: Peanut Allergy

Summary: open-label, follow-up study for subjects who completed the epitope study.


Eligibility criteria:
inclusion criteria: * completion of the epitope study exclusion criteria: * generalized dermatologic disease (for example, active atopic dermatitis, uncontrolled generalized active eczema, ichthyosis vulgaris) extending widely on the skin and especially on the back or arms with no intact zones to apply the viaskin patches. * diagnosis of asthma that evolved to severe, unstable or uncontrolled asthma

Keywords: epit epicutaneous immunotherapy viaskin
bimanual robotic exoskeletal platform for the treatment of the upper limb in patients with stroke. a feasibility study

Conditions: Stroke

Summary: the purpose of the study is to test the technical functionality, safety, and feasibility of a bimanual robotic exoskeletal platform and associated serious games in order to offer information on technological and functional advances that will be included in the device's finalization. in addition, a secondary goal will be to assess the therapeutic effects of a rehabilitation therapy based on the bimanual configuration, comparing it to a unimanual treatment delivered on the same platform (using the specific configuration).


Eligibility criteria:
inclusion criteria: * height between 150 and 190 cm; * weight not exceeding 130 kg; * ischemic injury; * first cortical and supra-tentorial event; * moderate motor deficit of the upper limb (score on the fugl-meyer assessment - upper extremity between 29 and 42); * time since stroke event between 1 and 6 months; * trunk control test score greater than or equal to 48; * healthy bone density and skeleton that does not suffer from unhealed fractures. exclusion criteria: * relevant medical comorbidities (severe neurological diseases, cardiovascular diseases, diabetes / unstabilized hypertension); * cognitive impairment that prevents understanding of the exercises administered; * unavailability to provide informed consent; * pregnant women; * severe spasticity (ashworth 4); * major muscle contractures; * excessive asymmetry in the length of the arms; * upper limb prostheses; * excessive joint limitations that make it difficult or painful to use the device; * use of pacemakers or implantation of active devices; * patients who already participate in another clinical study or who are already undergoing another similar robotic rehabilitation treatment.
assessment of frozen shoulder treatment using 432 hertz frequency music: a clinical trial

Conditions: Frozen Shoulder; 432 Hertz Frequency Music; Manual Therapy; Exercise

Summary: the goal of this clinical trial is to determine the effect of listening to music during the treatment of frozen shoulder on pain, normal range of motion, functional activity status and quality of life.upon recruitment, the subjects were randomly assigned to one of four treatment groups: group 1 received music + mobilization + exercise, group 2 received music + exercise, group 3 received mobilization + exercise, and group 4 received exercise only.

forty individuals diagnosed with frozen shoulder were randomly allocated into four distinct treatment groups. each participant received a total of eighteen treatment sessions, administered three days per week. pain levels, range of motion of the shoulder joint, functional status, general health condition, and quality of life were measured and recorded for each participant both before and after the treatment.

Eligibility criteria:
inclusion criteria: * idiopathic or primary adhesive capsulitis5,20,32, * a diagnosis of stage 2-3, * unilateral condition, * age between 30 to 65 years, * normal findings on radiographs within the previous 12 months, * no previous shoulder surgeries to the affected shoulder, * no previous manipulations under anesthesia of the affected shoulder, * passive joint movements limited to 50-75% of the normal range of motion of the joint, - and no hearing loss. exclusion criteria: * have shoulder girdle motor control deficits associated with neurological disorders.

Keywords: frozen shoulder 432 hertz frequency music manual therapy
study of the efficacy of preoperative cefuroxime prophylaxis to prevent surgical site infection in herniated disk surgery

Conditions: Surgical Wound Infection

Summary: the purpose of the study is to determine whether a single, pre-operative dose of cefuroxime is effective in preventing surgical site infection in patients undergoing surgery for herniated disk


Eligibility criteria:
inclusion criteria: * age older than 18 * spinal surgery for herniated disk exclusion criteria: * known or suspected hypersensitivity to cephalosporins * type i hypersensitivity to betalactamic antibiotics * severe renal function impairment * acquired immune deficiency syndrome (aids) or other conditions of severe immuno-suppression * antibiotic therapy for concomitant infection at the time of surgery * pregnancy * refusal to participate

Keywords: antibiotic prophylaxis bacterial infections / prevention & control surgical wound infection / prevention & control neurosurgery postoperative complications / prevention & control clinical trial [publication type]
effectiveness of quaker complete nutrition supplements for malnourished adults

Conditions: Malnutrition

Summary: intervention study in malnourished adults to assess whether a nutritional supplement given for 8 weeks in addition to the subject's usual diet improves body weight, body composition, biochemical and immune parameters.

criteria to be included in this study include: bmi (body mass index) under 19 free of cancer, hiv/aids, bulimia/anorexia and any malabsorption disorders description: we are studying whether adding nutritional shakes will help participants gain weight and improve their health and immunity. this study lasts about 8 weeks and has a total of 7 visits.

Eligibility criteria:
inclusion criteria: * bmi (body mass index) under 19 * adult exclusion criteria: * hiv/aids * cancer * malabsorption disorder

Keywords: malnutrition underweight low body weight bmi under 19 under nourished malnourished
impression & prosthesis quality made from different polyvinylsiloxane impression techniques

Conditions: Endodontically Treated Teeth; Missing Teeth; Discoloration, Tooth; Prosthesis Failure, Dental; Open Margin on Tooth Restoration

Summary: this randomized controlled trial is to clinically assess and compare impression quality of polyvinylsiloxane impression material using one step (experimental) and two step (control) impression techniques and its effect on marginal fit of prosthesis and proximal contact of prosthesis.

study participants will be randomly allocated to either of the two groups (experimental or control) through software-generated random numbers. indicated tooth will be prepared to receive a fixed prosthesis under local anesthesia as per standard guidelines. polyvinylsiloxane (pvs) impressions will be recorded in stock tray after moisture control, according to the assigned group. in experimental group, light body and putty pvs will be mixed simultaneously and placed in stock tray to record impressions in single stage. in control group, a putty pvs impression will be recorded first in stock tray and allowed to set. after setting of putty pvs, light-bodied pvs material will be applied to recorded impression surface and reseated in mouth to record final impression in second stage. all impressions will be disinfected according to the recommended guidelines. all impressions will then be assessed by a senior clinician using 3.5 x magnification loupe and graded according to the selected criteria. impressions will then be poured in dental stone and prosthesis will be manufactured in dental lab. participants will be recalled for prosthesis trial and fit assessment of prosthesis margins using a dental explorer instrument and visual evaluation. proximal contact of prosthesis will be graded according the criteria and assessed using dental floss. satisfactory prostheses will be cemented after final adjustments.

Eligibility criteria:
inclusion criteria: * indication of fixed-fixed partial denture or crown * good oral hygiene * sound abutment tooth (vital/non-vital) exclusion criteria: * failure to provide written consent to participation in study * long span bridges (greater than 3 units) * patients with bleeding disorders * cases indicated for resin-bonded prosthesis

Keywords: polyvinylsiloxane impression fixed prosthetics impression techniques single stage impression two step putty wash impression marginal fit prosthesis fit endodontically treated teeth
genomic predictors of decitabine response in patients with acute myeloid leukemia or myelodysplastic syndromes

Conditions: Leukemia, Myeloid, Acute; Myelodysplastic Syndromes

Summary: this clinical trial studies potential genetic markers which might be used to predict which patients with acute myeloid leukemia or myelodysplastic syndromes respond to decitabine. this study will contribute to the efforts to find effective and less toxic therapies to provide durable remissions in a significant proportion of elderly aml patients.


Eligibility criteria:
inclusion criteria: all of the following: * patient must have non-m3 aml or mds * an adverse risk karyotype defined by: * complex karyotype by cytogenetics, or * deletion of all or part of chromosome 5, 7, 12, or 17 defined by fish or cytogenetics, or * somatic tp53 mutation all of the following: 1. patient must have an ecog performance status ≤ 2. 2. patient must have \>10% disease burden measured by cytomorphology, flow cytometry, or cytogenetics. 3. patient must have peripheral white blood cell count \< 50,000/mcl. 4. patient must have adequate organ function, defined as: 1. total bilirubin \< 1.5 x uln 2. ast/alt \< 2.5 x uln 3. serum creatinine \< 2.0 x uln 5. patient must have undergone ≤ 2 cycles of prior hypomethylating agent (decitabine or azacitidine). 6. patient must be enrolled in hrpo# 201011766 ("tissue acquisition for analysis of genetic progression factors in hematologic diseases"). 7. patient must be \> 18 years of age. 8. patient must be able to understand and willing to sign an irb-approved written informed consent document. exclusion criteria: * patient must not be pregnant or nursing * patient must not have acute promyelocytic leukemia or t(15;17) observed by fish. * patient must not have known central nervous system (cns) leukemia * patient must not have a history of positive human immunodeficiency virus (hiv) serology * patient must not have a history of positive hepatitis c serology * patient must not have undergone prior allogeneic stem cell transplant * patient must not have any uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, ongoing or active graft-versus-host disease (gvhd), congestive heart failure of new york heart association (nyha) class 3 or 4, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situation that would limit compliance with study requirements * patient must not have had radiation therapy within 14 days of enrollment * patient must not have received any chemotherapy within 21 days of enrollment and any acute treatment-related toxicities must have returned to baseline. patients may be receiving hydrea at time of enrollment.
evaluating a preventive heart health programme for women at midlife

Conditions: Cardiovascular Disease; Menopause

Summary: this study examines the factors that limit or support the implementation of a pilot heart health program for perimenopausal women. the investigators evaluate the effectiveness of this program in raising awareness and promoting behavior change to maintain cardiovascular health.

cardiovascular disease (cvd) is the leading cause of mortality among women. heart-related conditions are responsible for the death of one out of every three women. in singapore, cvd in women causes more morbidity and mortality than breast and cervical cancer. the burden will be exacerbated by singapore's aging population and the longer life expectancy of women compared to men. primary and secondary prevention strategies are implemented to reduce the overall impact of cvd on public health. women who have traditional risk factors are at a greater risk of experiencing heart attacks compared to men with comparable risk factors. additional risks specific to women include a history of pregnancy complications, breast cancer, and premature menopause. cvds in women are frequently overlooked in terms of diagnosis and treatment. menopause is a phase in a woman's life that brings about significant changes to both her reproductive organs and her physical and psychological well-being. management issues encompass a spectrum of concerns, including immediate symptoms like insomnia and palpitations, intermediate concerns related to bone health, and long-term considerations associated with the development of cardiovascular disease. the american heart association (aha) provides guidelines for multidisciplinary care aimed at preventing cardiovascular disease (cvd) in women. countries like canada have established specialized organizations to address this issue. collaborative clinics involving cardiologists, gynecologists, and women's heart centers are crucial, even for women who are generally healthy. the objective of this study is to examine the factors that limit or support the implementation of a preventive heart health program for perimenopausal women. additionally, the investigators aim to evaluate the effectiveness of our pilot women's health program in raising awareness and promoting behavior change to maintain cardiovascular health.

Eligibility criteria:
inclusion criteria: * women aged 45-65 years at risk for cardiovascular disease or with pre-existing cardiovascular disease. * english speaking exclusion criteria: * pregnant women * unable to provide informed consent * women out of the menopause transition phase of 45-65 years of age.

Keywords: preventive cardiology menopause implementation
baseline vitamin d deficiency and covid-19 disease severity

Conditions: Vitamin D Deficiency; Covid19

Summary: it is known that vitamin d has been found to decrease incidence of viral respiratory infections, as well as have effects on multiple cytokines involved in immunomodulation and the bradykinin/renin-angiotensin system. recently, data was released showing a correlation between baseline vitamin d deficiency status and increased risk of contracting covid-19. separate analysis shows that many of the deleterious effects of covid-19 may be due to the bradykinin/ras system, and that vitamin d is one plausible treatment option to modulate these effects. studies are currently ongoing to determine if vitamin d supplementation of those hospitalized with covid-19 has a beneficial effect on patient outcomes. healthcare resources have been strained during the pandemic in areas of heavy caseload. it is possible that those with concurrent vitamin d deficiency and covid positivity have an increased need for escalation of care. a small study has been conducted in this area, but was limited by small number of subjects.

abstract: it is known that vitamin d has been found to decrease incidence of viral respiratory infections, as well as have effects on multiple cytokines involved in immunomodulation and the bradykinin/renin-angiotensin system. recently, data was released showing a correlation between baseline vitamin d deficiency status and increased risk of contracting covid-19. separate analysis shows that many of the deleterious effects of covid-19 may be due to the bradykinin/ras system, and that vitamin d is one plausible treatment option to modulate these effects. studies are currently ongoing to determine if vitamin d supplementation of those hospitalized with covid-19 has a beneficial effect on patient outcomes. objective: to determine if those hospitalized with covid-19 with baseline vitamin d deficiency, have worse outcomes during their stay than those who are not vitamin d deficient at baseline. design, setting, and participants: this is a retrospective cohort study at an urban academic medical center which included patients with a 25-hydroxycholecalciferol level measured within one year before being tested for covid-19 and hospitalized from march 9th to september 7th, 2020. exposures: vitamin d deficiency was defined by the last measurement of 25-hydroxycholecalciferol less than 20 ng/ml before covid testing (within one year). main outcomes and measures: the primary outcomes investigated include length of stay, need for supplemental oxygen, icu admission, need for invasive life support (mechanical ventilation, vasopressors, dialysis), and discharge status (discharged alive vs. death).

Eligibility criteria:
inclusion criteria: * covid 19 + * vitamin d level exclusion criteria: * age \< 18 * no associated vitamin d level

Keywords: prognosis
investigation of pain and anxiety during electrodiagnostic examination using self-selected music

Conditions: Pain; Anxiety

Summary: the investigators hypothesized that self-selected music played during electrodiagnosis is effective in relieving the discomfort caused by the procedures.


Eligibility criteria:
inclusion criteria: investigators recruited volunteer patient participants from patients referred to the electrodiagnosis laboratory of department of physical medicine and rehabilitation in a medical center using convenient sampling. the inclusion criterion is: * adult patient with working diagnosis of possible neurological disorder and * is referred for both nerve conduction study and needle electromyography exclusion criteria: the exclusion criteria are: * conscious disturbances, * cognitive impairment, or * language dysfunction.