Kornimate/medical-research-clean huggingface dataset:
ivus guided pci in patients with chronic kidney disease

Conditions: Coronary Artery Disease

Summary: the incidence of contrast-induced nephropathy (cin) is high (\> 25%) in patients with severe chronic renal disease (ckd) who undergo a percutaneous coronary procedure. the development of cin is a factor of poor prognosis and is associated with the occurrence of irreversible ckd, the need for dialysis, increased length of stay and hospital costs as well as the risk of death. there is no specific treatment for n-pci, so its prevention is essential. although many studies have been conducted to identify, compare and implement different pharmacological strategies for the prevention of cin before percutaneous coronary procedurse, few per-procedural strategies have been studied to prevent this risk. intracoronary ultrasound (ivus) is an essential tool, used routinely to guide percutaneous coronary procedures thanks to ultrasound, it does not require the injection of iodine contrast. the main objective is to show that an ivus-guided "zero-contrast" coronary angioplasty strategy in patients with severe renal impairment decreases the incidence of cin within 72 hours of procedure.

the incidence of contrast-induced nephropathy (cin) is high (\> 25%) in patients with severe chronic renal disease (ckd) who undergo a percutaneous coronary procedure. the development of cin is a factor of poor prognosis and is associated with the occurrence of irreversible ckd, the need for dialysis, increased length of stay and hospital costs as well as the risk of death. there is no specific treatment for n-pci, so its prevention is essential. although many studies have been conducted to identify, compare and implement different pharmacological strategies for the prevention of cin before percutaneous coronary procedurse, few per-procedural strategies have been studied to prevent this risk. intracoronary ultrasound (ivus) is an essential tool, used routinely to guide percutaneous coronary procedures thanks to ultrasound, it does not require the injection of iodine contrast. the main objective is to show that an ivus-guided "zero-contrast" coronary angioplasty strategy in patients with severe renal impairment decreases the incidence of cin within 72 hours of procedure.

Eligibility criteria:
inclusion criteria: * patients over 18 years old * indication for pci * chronic kidney disease with creatinine clearance ≤ 30 ml/min/1.73m² * feasibility of ivus determined by 2 trained interventional cardiologist * affiliated to social security exclusion criteria: * iodine contrast injection in the previous 72 hours * known allergy to iodine contrast * permanent dialysis * chronic total occlusion * hemodynamic instability * legal protection * pregnant of breastfeeding patients * patients on "ame"

Keywords: coronary artery disease chronic kidney disease contrast induced nephropathy ivus
effects of infant massage on acceptance, commitment and conscience of influence of parents with down syndrome babies

Conditions: Parent-Child Relations

Summary: this study aims to analyze whether the course of infant massage serves as a tool to improve acceptance, commitment and awareness of influence of parents of babies with down syndrome. these variables will be measure before and after the course of infant massage in the experimental group, investigators will make measurements with the same rate in the control group, but they will receive the course after the measurements.

in the present study, investigators propose to study the effects of infant massage in the levels of acceptance, commitment and awareness of influence of parents of babies with down syndrome. the measuring instrument of acceptance, commitment and awareness of parental influence will be the "this is my baby interview". two groups of intervention will be analysed, the experimental, in which parents have participated and applied the knowledge learned in the course of infant massage, and control, which does not receive the infant massage course during the study. parents and babies of both groups have been evaluated twice, at the beginning of the intervention (pretest) and at the end after five weeks (postest). the study population consists of father or mother of 32 infants with down syndrome between 4 and 8 months old.

Eligibility criteria:
inclusion criteria: * parents with babies with down syndrome between 4 and 8 months old. exclusion criteria: * parents with babies without down syndrome.

Keywords: down syndrome acceptance commitment concience of influence
repair versus non-repair of the aortic arch in type a aortic dissection

Conditions: Aortic Dissection; Aortic Arch; Aortic Dissection Rupture; Aortic Dilatation

Summary: acute stanford type a aortic dissection (taad) is a life-threatening clinical status requiring surgery that is usually performed as a salvage procedure.we planned a multicenter study to evaluate the balance between the patient's condition and those therapeutic strategies that may limit the risk of late adverse events in patients who will be underwent surgery for appropriate management of taad

substantial evidence has suggested a decrease of early mortality during the last years, however recently the nordic consortium for acute type a aortic dissection registry recorded 18% of 30-day mortality after surgery for ataad. similarly, the prospective german registry for acute aortic dissection type a confirmed this data reporting a 30-day mortality of 16.9%. again, results from recent analysis of the society of thoracic surgeon database that report 7353 procedures from 2014 and 2017 for acute taad revealed a 30-day mortality of 17%. understanding the balance between the patient's conditions which may not allow extensive procedure and those treatment strategies which may limit the risk of late adverse events in patients who remain alive long after the surgery is essential for an appropriate management of ataad. the best treatment option in patients with ataad is dictated by the balance between patient conditions that may not allow for extensive procedures and those more conservative treatment strategies that limit the risk of late adverse events in patients who remain alive long after surgery. surgery. however, previous evidence from large series of patients do not provide information on the long-term durability of these procedures. here investigators planned a multicenter study to evaluate the contemporary early outcomes and duration of different surgical strategies for 15-year acute ataad in a large study population.

Eligibility criteria:
inclusion criteria: * patients aged \> 18 years * taad or intramural hematoma involving the ascending aorta * symptoms started within 7 days from surgery * primary surgical repair of acute taad * any other major cardiac surgical procedure concomitant with surgery for taad. exclusion criteria: * patients aged \< 18 years * onset of symptoms \> 7 days from surgery * prior procedure for taad * concomitant endocarditis; * taad secondary to blunt or penetrating chest trauma.

Keywords: type a aortic dissection (taaad) root-sparing replacement ascending aorta replacement partial arch repair total arch replacement (tarp) frozen elephant trunk (fet) hemiarch procedures
duodenal levodopa infusion, quality of life and autonomic nervous system in parkinson's disease

Conditions: Parkinson's Disease

Summary: the aim of the study is to assess the effect of continuous levodopa infusion on autonomic nervous system in patients with parkinson's disease (pd), blood pressure regulation and sweating. the investigators' hypothesis is that levodopa infusion may alleviate hyperhidrosis and orthostatic hypotension.

parkinson's disease (pd) is one of the most common neurodegenerative disorders with increasing prevalence because of aging population. the main symptoms include rigidity, hypokinesia, tremor and impaired balance, but the disease also causes autonomic dysfunction. motor fluctuations are common treatment related problems in pd, around 50-70% of patients treated with levodopa finally develop motor fluctuations. continuous duodenal levodopa infusion has been effective in the treatment of motor dysfunction in advanced pd. however, little is known of its effects on autonomic nervous system.

Eligibility criteria:
inclusion criteria: * diagnosis of idiopathic parkinson's disease: diagnosis made at least five years earlier * positive response to levodopa * motor fluctuations that cannot be adequately controlled with oral medication * no signs or symptoms of cerebellar dysfunction or vascular parkinsonism exclusion criteria: * severe cognitive symptoms * glaucoma * severe arrythmias * severe asthma or copd * heart, liver or kidney failure * no significant vascular lesions in brain mri imaging.

Keywords: parkinson's disease autonomic nervous system levodopa infusion
conservative versus liberal red cell transfusion in myocardial infarction trial: the crit pilot

Conditions: Myocardial Infarction; Anemia

Summary: the purpose of this trial is to determine whether a conservative or a liberal blood transfusion strategy is better for patients with a heart attack and a low blood count.

the current standard of care for patients with heart attacks is to transfuse red blood cells when the hematocrit (red blood cell count) drops below 30 percent. however, there is little scientific basis for this current standard, and recent research has demonstrated that it is safe to allow the hematocrit (red blood cell count) to drop significantly lower in severely ill medical patients and in patients with heart disease undergoing major surgery. the investigators therefore propose this pilot trial to begin to determine whether or not it is safe to apply a more conservative blood transfusion strategy to patients with heart attacks. in this study, patients who are within 72 hours of the onset of a heart attack and who are anemic (have a low red blood cell count) will be randomly assigned to one of two transfusion strategies while they are in the hospital: a liberal strategy of transfusing blood when the hematocrit falls below 30 percent (the current standard) or a conservative strategy of transfusing blood only when the hematocrit falls below 24 percent. it will then be determined which group fares better over the next 30 days. the plan is to enroll 92 patients in this pilot trial in order to allow the researchers to plan for a much larger, definitive trial of this important question. it is anticipated that the conservative transfusion strategy will be similar to the standard (liberal) strategy in terms of patient outcomes.

Eligibility criteria:
inclusion criteria: all of the following must be present: * acute myocardial infarction with presentation within 72 hours of randomization (acute myocardial infarction is defined as ischemic-type chest discomfort lasting at least 30 minutes associated with creatinine kinase mb (ckmb) or troponin \>upper limit of normal \[uln\]) * admission to ccu * hematocrit .30 or less * written, informed consent exclusion criteria: * inability or unwillingness to receive red cell transfusions * active bleeding (overt blood loss accompanied by a decrease in hematocrit of at least 5% in the preceding 12 hours) * receipt of red cell transfusion within 7 days of randomization * prior severe transfusion reaction * pregnancy * imminent death * decision to provide limited care * age \<21 * participation in another clinical trial in which blood transfusion is a requirement or a component of a primary or secondary endpoint * previous participation in the crit pilot

Keywords: myocardial infarction anemia erythrocyte transfusion
oxigen: oxford imagery generation: investigating the effects of an internet based computer program in depression

Conditions: Depression

Summary: this research study is designed to investigate the effects of an online computer program, called oxigen (oxford imagery generation), on thinking style and mood in depression. the oxigen program will be delivered online over four weeks and with follow-up at one, three and six months. this will inform potential future development of this computerized task into an online intervention to modify negative thinking styles in depression.


Eligibility criteria:
inclusion criteria: * willing and able to give consent to the study * male or female, aged between 18 and 65 years * current major depressive episode (assessed by semi-structured clinical interview) * access to internet in order to complete the online program * able to travel to research centre for assessment appointments * fluent in written and spoken english exclusion criteria: * meets criteria for current psychotic disorder * history of mania or hypomania as assessed by semi-structured clinical interview, or has elsewhere received a diagnosis of bipolar disorder * antidepressant medication begun or changed in dosage during last month * meets criteria for current substance abuse disorder * involved in other current treatment trials * currently receiving psychological therapy

Keywords: depression cognitive bias internet
prediction of fetal lung maturity

Conditions: Fetal Distress

Summary: diabetes is the most common medical complication of pregnancy in the united states four to five percent of pregnancies are complicated by diabetes. pregestational diabetes (diabetes diagnosed before pregnancy, type 1 or type 2 diabetes mellitus) comprises approximately 13 percent of all diabetes in pregnancy, while gestational diabetes ( diabetes with onset or first recognition in pregnancy) comprises the remaining 87 percent . the prevalence of pregestational diabetes has been increasing due to the increasing prevalence of type 2 diabetes in women of reproductive age . the mainstay of the medical management of pregestational diabetes involves frequent monitoring of blood glucose levels with adjustment of diet and insulin therapy to achieve normoglycemia. normoglycemia is important because maintenance of maternal blood glucose concentration at or near normoglycemic levels decreases the likelihood of adverse pregnancy outcomes, such as miscarriage , congenital anomalies , macrosomia and fetal death.


Eligibility criteria:
inclusion criteria: * all pregnant diabetic women * 37 weeks gestational age . exclusion criteria: * women before 37 and after 39 weeks gestational age * pregnancies with known fetal anomalies that may potentially affect the lung maturity . * multiple pregnancies. * women received steroids for lung maturation after ultrasound image acquisition and before delivery . * women with premature rupture of membranes (prom) * pregnancies complicated by medical disorders other than diabetes mellitus . * failure to obtain an informed consent .
two cycles of pad combination by ahct in mm

Conditions: Multiple Myeloma

Summary: based the proven efficacy and the ability to induce rapid response of various combinations of bortezomib including pad combination in refractory and newly diagnosed patients with multiple myeloma, the investigators intend to investigate the efficacy of 2 cycles of pad combination (ps-341/bortezomib, adriamycin, and dexamethasone) and to examine the feasibility of harvesting g-csf mobilized pbsc and performing early ahct after 2 cycles of pad.

1.pad combination chemotherapy * bortezomib 1.3 mg/m2 will be given by intravenous bolus injection on days 1, 4, 8, 11 of each cycle. oral or intravenous dexamethasone 40 mg will be administered on days 1-4 and 8-11 with doxorubicin 9 mg/m2 by intravenous bolus on days 1-4 of each cycle. the cycle will be repeated every 3 weeks. a total of 2 cycles is planed before ahct. * for mobilization, g-csf 10ug/kg/d alone will be given by subcutaneous injection from day 12 of the second pad cycle until completion of harvesting. melphalan 100 mg/m2/day will be administered on day -3 and day -2 for high-dose chemotherapy. -maintenance :thalidomide 100 - 200 mg/d for 2 years

Eligibility criteria:
inclusion criteria: * patients with newly diagnosed symptomatic mm (see appendix i) * patients should be eligible for ahct. * patients should have measurable serum or urine paraprotein. * the performance status of the patients should be 70 or over by karnofsky performance scale * adequate hepatic and renal function: serum bilirubin \< 1.5 x the upper limit of normal (uln), serum alanine aminotransferase (alt)/aspartate aminotransaminase (ast) values \< 2.5 x uln, serum creatinine \< 1.5 x uln * adequate cardiac function: ejection fraction \> 40% by echocardiogram or radionuclide heart scan exclusion criteria: * prior chemotherapy for myeloma except 4 days of dexamethasone up to 40 mg per day or localized radiotherapy or plasmapheresis for the treatment of clinically significant hyperviscosity syndrome * have a peripheral neuropathy of grade 2 or more within 14 days of enrollment. * significant infection

Keywords: mm
gefitinib versus pemetrexed for previously treated nsclc patients

Conditions: Previous Treated Metastatic Non-small Cell Lung Cancer

Summary: to compare the efficacy of gefitinib versus pemetrexed as second-line chemotherapy for patients with previous treated non-small cell lung cancer


Eligibility criteria:
inclusion criteria: * cells pathologically diagnosed as histological or radical surgery or radiation therapy is not possible stage iiib and stage iv non-small-cell lung cancer patients * second line * ecog 0～2 * patients with normal liver function and renal function exclusion criteria: * patients with severe acute infection requiring antibiotic therapy * patients who have received treatment in other areas of cancer within 5 years * during pregnancy and lactation patients

Keywords: pemetrexed gefitinib iressa alimta
temperature control in central fever in the neuro-icu

Conditions: Fever; Brain Hemorrhage

Summary: there are few treatments for central fever (fever that is due to the central nervous system, as opposed to an infectious source). we hypothesize that an externally applied cooling blanket will reduce temperature in neurologically ill patients with central fever.


Eligibility criteria:
inclusion criteria: * two or more days with core temperature ≥ 100.4f * approval of the patient's primary attending physician * need for core temperature measurement independent of the study. * admission to the neuro-icu \[intensive care unit\] for an underlying condition exclusion criteria: * evidence for an infectious cause of fever, such as pneumonia, bacteremia, cns \[central nervous system\] infection or urinary tract infection. * expected death from any cause * known sensitivity to the device * history of pre-admission hypothalamic dysfunction or known temperature dysregulation * use of 2 or more vasopressor medications, since this may make a local skin reaction to the device more likely * hemodynamic instability

Keywords: subarachnoid hemorrhage intracerebral hemorrhage fever
assessment of the efficacy of scorpion antivenom therapy in a dose-response manner, in patients with scorpionism

Conditions: Centruroides Envenomation

Summary: the clinical study aims to compare the effectiveness of applying two different regimens of scorpion antivenom therapy. in the first regimen (control), the medication is administered to all patients, and depending on the severity of the condition, the dosage varies. in the experimental regimen, an identical dose of scorpion antivenom is administered to patients exhibiting signs and symptoms of scorpion sting intoxication, in addition to pain and other symptoms at the sting site. the primary response variable is the time taken for signs and symptoms to resolve, but differences in complications, adverse effects, venom and antivenom concentration in the blood, and the need for other therapeutic measures are also evaluated.


Eligibility criteria:
inclusion criteria: * individuals aged 18 or older presenting with a diagnosis of scorpionism to the emergency department. * treated solely with paracetamol, scorpion antivenom, saline solution, and local ice application. * any gender. * less than two hours elapsed since scorpion sting. * willing to participate in the study through written informed consent. exclusion criteria: * allergies or contraindications to any of the study medications. * uncertainty regarding scorpion sting. * previous treatment by another physician. * intramuscular administration of scorpion antivenom due to urgent clinical conditions. * decision not to provide informed consent. * any limitations hindering the proper understanding of study participation.

Keywords: centruroides antivenom scorpion antivenom scorpion envenomation
comparative study of two forms of topical dexchlorpheniramine maleate (cream versus gel) for insect bites

Conditions: Insect Bites

Summary: insect bite related symptoms (pruritus and papules) are caused by the release of histamine by mast cells in the skin. topical anti-histaminics can be used to promote relief of these symptoms. dexchlorpheniramine maleate 1% cream is a topical anti-histaminic formulation approved by anvisa in brazil for the relief of skin irritation and allergies, including the ones caused by insect bites. the aim of the present study is to demonstrate non-inferiority of a new pharmacological preparation of dexchlorpheniramine maleate (1% gel) with the standard preparation (1% cream) for the relief of insect bite related symptoms and to demonstrate the safety of both preparations.


Eligibility criteria:
inclusion criteria: * presence of papules resulting from insect bites within the last 72 hours; * presence of symmetric lesions to compare one side to the other; * compliance of the subject to the treatment protocol; * agreement with the terms of the informed consent by the participants or their legal guardians when younger than 18 years old. exclusion criteria: * pregnancy or risk of pregnancy; * lactation; * use of topical or systemic anti-inflammatory, anti-histaminics or immunosuppressive drugs within the last 48 hours prior to the study; * history of atopy or allergic diseases; * history of allergy of any component of the formulations; * other conditions considered by the investigator as reasonable for non-eligibility.

Keywords: insect bites dexchlorpheniramine gel cream
laser acupuncture for meniere disease

Conditions: Meniere Disease

Summary: objective: to evaluate the effect of laser acupuncture for the patients meniere disease. methods: we enrolled 324 patients at beijing tongren hospital. patients completed outcome measures at baseline, 3 months, 6 months, and 12 months. video head impulse test (vhit), the caloric test, tinnitus handicap inventory (thi), dizziness handicap inventory (dhi), pure tone audiometry (pta), and visual scale of ear stuffiness to evaluate the therapeutic effects. a difference of p \< 0.05 was considered statistically significant.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of meniere disease. exclusion criteria: 1. serious mental illness or social problems, and neurological disorders, and systemic diseases, such as malignant tumors, and other serious consumptive diseases. 2. planning for pregnancy, those in pregnancy, or those who were lactating.

Keywords: meniere disease rct laser acupuncture