Kornimate/medical-research-clean huggingface dataset:
7 tesla mri neuroimaging in testicular cancer patients with hypogonadism and on androgen replacement therapy

Conditions: Hypogonadism; Malignant Testicular Germ Cell Tumor

Summary: this study evaluates 7 tesla (t) magnetic resonance imaging (mri) in observing changes in the brain (neuroimaging) in testicular cancer patients who have decreased testosterone (hypogonadism) and are on testosterone (androgen) replacement therapy. symptoms of hypogonadism can include fatigue, weakness, loss of libido, depression, poor concentration and erectile dysfunction. some patients experience mental changes after diagnosis and treatment. there is some evidence that hypogonadism produces structural changes in the brain. the 7t mri uses radio waves and a very powerful magnet linked to a computer to create detailed pictures of areas inside the body. this study may help researchers learn if 7t mri can produce better images to assess the changes in the brain structure of testicular patients with hypogonadism and on androgen replacement therapy (art).

primary objective: i. to assess longitudinal structural changes in brain architecture using mri in hypogonadal men with testis cancer being treated with androgen replacement therapy. outline: this is an observational study. patients undergo 7t mri over 1-2 hours at baseline and at 12 months after baseline. patients also undergo a proctored cognitive assessment over approximately 1 hour prior to each mri. additionally, patients undergo blood sample collection at screening and at 12 months after baseline mri.

Eligibility criteria:
inclusion criteria: * males age \>= 18 years * diagnosed with germ cell tumor of the testis (seminoma or non-seminoma) and treated with radical orchiectomy * diagnosed with hypogonadism and started androgen replacement therapy 6 months prior (+/- 2 weeks) * ability to understand and the willingness to sign a written informed consent * ability to undergo imaging procedure without any form of sedation exclusion criteria: * history of any neuropsychiatric disease * history of narcotic use or psychiatric medications * history of art prior to current art regimen * standard contraindications for mri: * prior work as a machinist or metal worker, or history of metal being removed from the eyes * cardiac pacemaker or internal pacing wires * non-mri compatible vena cava filter, vascular aneurysm clip, heart valve, spinal or ventricular shunt, optic implant, neuro-stimulator unit, ocular implant, or intrauterine device, or * claustrophobia, or uncontrollable motion disorder * current active second malignancy
lacto-fermented sauerkraut in the treatment of irritable bowel syndrome

Conditions: Irritable Bowel Syndrome

Summary: the aim of the present study is to assess the efficacy of traditionally fermented sauerkraut in the treatment of irritable bowel syndrome.

irritable bowel syndrome (ibs) is a chronic gastrointestinal (gi) disorder that affects around 11% of the population globally. several factors have been implicated in the pathogenesis of ibs, including psychological stress, gastrointestinal motility, and diet . more recently, it has become clear that the gastrointestinal microbiota may play a critical role in the pathophysiology of this functional gi condition. several studies have shown that an altered gut microbiota profile is present in at least some subgroups of ibs patients. this may, in part, explain why a proportion of ibs patients have elevated levels of inflammatory mediators in systemic circulation. gut microbiome manipulation, for example through the use of probiotic and prebiotic supplements, has shown some promise in the treatment of ibs. however, the research in this area is still in its infancy, and it remains unclear what type of intervention that is the preferred choice in cases of ibs. several studies have investigated how the use of probiotic supplements containing bifidobacteria and lactobacilli affect the clinical outcome of patients with ibs. however, to date, no studies have assessed whether fermented vegetables, a "natural" source of probiotic bacteria such as lactobacillus plantarum, are useful in the treatment of ibs.

Eligibility criteria:
inclusion criteria: rome iii criteria (criteria fulfilled for the last 6 months with symptom onset at least 3 months prior to diagnosis): recurrent abdominal pain or discomfort at least 3 days/month in the last 3 months associated with two or more of the following: 1. improvement with defecation 2. onset associated with a change in frequency of stool 3. onset associated with a change in form (appearance) of stool exclusion criteria: * psychiatric disorder * metabolic disease * chronic infection * organic gastrointestinal disorder * pregnancy * breastfeeding

Keywords: irritable bowel syndrome the human microbiome microbiota gut microbiota probiotics sauerkraut
dexmedetomidine in pediatric cardiac surgery

Conditions: Acute Kidney Injury

Summary: dexmedetomidine is a selective α-2 receptor agonist with a sedative and cardiopulmonary profile that makes it an attractive anesthetic for pediatric patients with congenital heart disease (chd). the aim of this study was to investigate the renal protective effect of dexmedetomidine in the perioperative setting in children with heart disease. total 144 pediatric patients allocated dexmedetomidine (dex) and did not receive the drug (nodex) group. the primary objective of this study was to assess the relationship between the use of intraoperative dexmedetomidine and the incidence of acute kidney injury in pediatric patients undergoing cardiopulmonary bypass. the secondary objective was to determine whether there was an association between dexmedetomidine use and duration of mechanical ventilation or cardiovascular icu stay.


Eligibility criteria:
inclusion criteria: * patients undergoing congenital cardiac surgery exclusion criteria: * history of allergy or anaphylaxis to study drug * preexisting renal dysfunction (preoperative creatinine \>1.5mg/dl) * diabetes * liver profile abnormality
air pollution and copd exacerbation

Conditions: Pollution; Exposure; Chronic Obstructive Pulmonary Disease

Summary: there is an excess of hospitalization rates for acute exacerbation of copd in picardy compared to the national data. a first study realized in picardy has shown a link between air quality and copd. nevertheless, the particles type is unknown and according to it, impact on copd could be different. the investigator goal is to find a correlation between acute exacerbation of copd consultation rate and daily ultra thin particles in haut de france. the investigators will correlate the particles composition with daily acute exacerbation of copd rate. all copd patients with a diagnosis of acute exacerbation in emergency room in university hospital of amiens-picardie and lille, and clinique de l'europe between 01/01/2020 and 31/12/2020 will be included. for each patient, home and work address will be collected. the duration of 1 year was chosen to take into account seasonal variations. in parallel, a daily report of the rate of ozone, particles (pm2.5 and pm10), dioxide nitrogen but also odours and pollens will be done by atmo haut de france.


Eligibility criteria:
inclusion criteria: * copd patients with a diagnosis of acute exacerbation of copd in the emergency room of amiens and lille centers * adults * patients able to express consent * signed written informed consent form * covered by national health insurance exclusion criteria: * patients non covered by national health insurance * patients not able to express consent * minors

Keywords: pollution chronic obstructive pulmonary disease ultrathin particles
evaluation the operative procedure among patients that suffer from tear of the distal tendon of the biceps

Conditions: Biceps Tendon Rupture

Summary: background: rupture of the distal tendon in biceps muscle is a rare injury. the state of the art treatment is surgical procedure. objective: evaluation of the surgical procedure among patients that suffered from methods: the investigators will review files from 2003-2010 of patients that gone through the operation. the investigators will record pre-operation and post-operation process including complications and rehabilitation. the investigators will invite them to the clinic for exams, clinical questionnaires.


Eligibility criteria:
inclusion criteria: 1.see population description exclusion criteria: 1. unwillingness to come to the clinic visit.
comparison of pelvimetric measurements between mri and low-dose stereoradiography (eos® imaging system)

Conditions: Breech Fetal Presentation

Summary: the main objective of this study is to compare pelvimetric measurements performed by magnetic resonance imaging (mri) and by the eos imaging system.

during pregnancy, after failure of external manual version (emv) in case of breech fetal presentation, a radiological pelvimetry is performed to evaluate the measurements of the pelvis and decide on the appropriate mode of delivery. several imaging modalities are used, including pelvic computed tomography (ct),and magnetic resonance imaging (mri) of the pelvis. ct scan has the disadvantage of maternal irradiation and mri has the disadvantage of an inaccurate morphological analysis.the eos® system is an imaging tool used in radiopediatric to allow precise morphological analysis of bone masses with minimal irradiation. the quality of the morphological analysis and measurements provided by the eos® imaging system is the reason for proposing this study comparing the pelvimetric measurements obtained by mri and by the eos® imaging system.

Eligibility criteria:
inclusion criteria: * patients \> 18 years of age * patient requiring pelvimetry (breech fetus) * gestation \> 36 sa (weeks of amenorrhea) * patients with bmi \< 35 * affiliated to social security or similarly regime * patients who gave their consent to participate in the study (patient having agreed to perform both examinations: mri and eos system) exclusion criteria: * patient with a contraindication to mri (claustrophobia, pace-maker, intracorporeal metallic element) * patient with a contraindication to performing eos® (person not standing alone) * patient who are in exlusion period of another interventiionnal study * person deprived of freedom by judicial or administrative decision; person hospitalized for psychitric care; person under legal protection measure.

Keywords: breech fetal presentation mri eos imaging system pelvimetric measurements
prophylactic ncpap following bowel surgery (bio-reb file 11-27)

Conditions: Postoperative Pulmonary Atelectasis; Surgery

Summary: the purpose of this study is to determine whether prophylactic nasal continuous positive airway pressure (ncpap) in the post-anaesthesia care unit (pacu) improves post-operative pulmonary function following elective bowel surgery. the investigators hypothesize that one hour of ncpap in the pacu will result in a higher partial pressure of arterial oxygen (pao2) when compared to the standard treatment of low flow oxygen applied by face mask.

post-operative pulmonary complications, such as hypoxemia, pneumonia and respiratory failure, occur in 5-10% of patients following abdominal surgery. these post-operative pulmonary complications result in increased morbidity, mortality, icu admission, length of hospital stay and resource use. cpap has shown to be an effective treatment for hypoxemia following abdominal surgery. it decreases atelectasis formation the risk of pneumonia. application of ncpap to treat hypoxemic respiratory failure following thoraco-abdominal surgery has shown to decrease endotracheal intubation. nasal cpap has shown to be effective prophylaxis following elective cardiac and thoraco-abdominal aortic surgery. it reduces the incidence of hypoxemia, pneumonia, re-intubation and re-admission to the icu. it has also shown to decrease the length of hospital stay. the use of ncpap immediately post-operatively in the pacu following abdominal surgery has not been evaluated. nasal cpap is better tolerated than full face mask cpap. it allows for effective clearance of respiratory secretions, improved communication and decreases claustrophobic sensation. the pacu is a transition period from general anaesthesia into the post-operative recovery phase. during this time, residual anaesthetic causes decreased level of consciousness and sub-optimal respiratory effort. reversal agent for neuromuscular blockade has often not reached its peak effect. inadequate pain control may further decrease respiratory effort. this transition period may be when maximal atelectasis of alveolar lung units occurs. this time period may be optimal for the application of ncpap for prophylaxis against hypoxemia. it may improve post-operative pulmonary function which could decrease post-operative morbidity, mortality, length of hospital stay and resource use.

Eligibility criteria:
inclusion criteria: * patients scheduled to undergo elective laparotomy for bowel surgery exclusion criteria: * age \< 18 years * postoperative admission to the intensive care unit * a history of allergy/intolerance to ametop

Keywords: continuous positive airway pressure postoperative complications respiratory insufficiency colorectal surgery
reinvent: a brain and muscle computer interface for stroke

Conditions: Stroke

Summary: stroke is a leading cause of adult disability in the united states. high doses of repeated task-specific practice have shown promising results in restoring upper limb function in chronic stroke (\>6 months after onset). however, it is currently challenging to provide such doses in standard clinical practice. at-home telerehabilitation services supervised by a clinician are a potential solution to provide higher-dose interventions. however, telerehabilitation systems developed for repeated task-specific practice typically require a minimum level of active movement. therefore, severely impaired people necessitate alternative therapeutic approaches. measurement and feedback of electrical muscle activity via electromyography (emg) have been previously implemented in the presence of minimal or no volitional movement to improve motor performance in people with stroke. specifically, muscle neurofeedback training to reduce unintended co-contractions of the impaired hand may be a targeted intervention to improve motor control in severely impaired populations. in this study, we examine the effects of a low-cost, portable, and modular emg biofeedback system (tele-reinvent) for supervised and unsupervised upper limb telerehabilitation after stroke during a 6-week home-based training program that reinforces activity of the wrist extensor muscles while avoiding coactivation of flexor muscles via computer games.


Eligibility criteria:
inclusion criteria: * moderate to severe upper extremity hemiparesis and residual hand function (e.g., less than 20 degrees of active wrist or finger extension and enough muscle activity to measure with electromyography). exclusion criteria: * taking anti-spasticity medication * significant vision loss (corrected vision is acceptable) * receptive aphasia * hand contractures * secondary neurological disease
quality of life and symptoms in patients with newly diagnosed myelodysplastic syndromes

Conditions: Adult; Myelodysplastic Syndromes

Summary: rationale: gathering information about quality of life, fatigue, and other symptoms from patients with myelodysplastic syndromes may help doctors learn more about the disease and may help plan treatment. purpose: this clinical trial is studying quality of life and symptoms in patients with newly diagnosed myelodysplastic syndromes.

this study will ultimately aim at providing the scientific community with additional patient-reported health status data to support and further facilitate the clinical decision-making process. this project has thus a number of goals. the main objective of the protocol is to improve our understanding of the possible added prognostic value of patients' judgment on their own health status and its potential clinical implications. this would aim at providing clinicians with an easy and brief to administer patient-reported health status scale or tool to be used to make more informed treatment decisions. in addition, along with other recent evidence (also looking at the prognostic value of patients' health status judgment in mds patients), the data of this research could possibly serve to devise a patient-based prognostic index to be used in this higher risk population.

Eligibility criteria:
inclusion criteria * patients with newly diagnosed myelodysplastic syndrome (mds) according to who classification with any known ipss risk score category. the initial diagnosis of mds is acceptable within 3 months before date of registration. * having a full baseline qol evaluation completed (i.e. eortc qlq-c30; eq5d; facit-fatigue and control preference scale). * adult patients (≥ 18 years old). * written informed consent provided. exclusion criteria * patients who have received prior treatment other than platelets or rbc transfusions, iron chelation, antibiotic/virostatic drugs, vitamins; * patients with therapy related mds. * having any kind of psychiatric disorder or major cognitive dysfunction. * not able to read and understand local language.

Keywords: adult de novo myelodysplastic syndromes quality of life patient reported outcomes
corrective calcaneal kinesiology tape in adolescents with pronated foot

Conditions: Physical Disability; Physical Therapy Modalities

Summary: the aim of this study is to find the effect of a program of corrective kinesiotaping on pain intensity, foot function, and the sonographic picture of plantar fascia in adolescents with pronated feet.this study hypothesizes that there will be a statistically significant effect of a program of application of the corrective technique of kinesiotaping on plantar heel pain, foot function, and the sonographic picture of plantar fascia in a sample of egyptian adolescents suffering from pronated feet.

this study will be conducted to find the effect of a program of corrective kinesiotaping on pain intensity, foot function, and the sonographic picture of the plantar fascia in adolescents with pronated feet. thirty adolescents suffering from plantar heel pain associated with pronated feet will be included in this study. they will be distributed randomly into 2 groups: group a will receive corrective kinesiotaping (50-75% stretch) for 6 weeks, 2 times per week with 1 day of rest; group b will receive a home program of intrinsic foot strengthening and stretching exercises. data will be collected pre- and post-intervention for all groups by using the visual analog scale (vas), the first two subscales of the foot function index (ffi), and a sonographic picture of the foot for each adolescent. participants will be recruited from outpatient clinics and schools.

Eligibility criteria:
inclusion criteria: * children with unilateral or bilateral plantar fasciitis. * pronated foot or foot on weightbearing in the navicular drops test. * pain and tenderness to palpation at the medial tubercle of the calcaneus for a minimum of 6 weeks and maximum of 6 months exclusion criteria: * corticosteroid injection of the heel within the past 3 months. * posterior heel pain. * systemic inflammatory conditions. * diabetes. * surgery of the foot. * neuromuscular conditions e.g. cp. * individuals with bmi \> 25. * individuals engaged in regular athletic activities

Keywords: kinesiology tape , plantar fasciitis
efficacy and safety dose titration study of botulinum toxin type a to treat spasticity in the leg and arm

Conditions: Spasticity of the Upper and Lower Limb Due to Cerebral Causes

Summary: the purpose of this study is to determine whether injections with increasing doses (up to 800 units) of botulinum toxin type a into muscles of the leg and/or arm are safe and effective in treating patients with spasticity on one body side due to cerebral causes.

a dose-titration approach will be used over three injection cycles, with a flexible observation period after injections of 12-16 weeks and a total duration of up to 48 weeks. cycle 1 and 2: upper and/or lower limb to be treated; cycle 3: upper and lower limb to be treated.

Eligibility criteria:
inclusion criteria: * upper and lower limb spasticity of the same body side due to cerebral causes * time since event leading to spasticity in the target body side greater than 12 weeks * need for 800 units botulinum toxin type a exclusion criteria: * body weight below 50kg * fixed contractures of the target joint * generalized disorders of muscle activity like myasthenia gravis that preclude use of botulinum toxin type a * infection at the injection site
avoiding postinduction hypotension: the clinical zero-hypotension proof-of-concept study

Conditions: Hypotension; Anesthesia; Hypotension on Induction

Summary: in this clinical proof-of-concept study, the aim is to investigate the efficacy of a hypotension avoidance strategy to prevent post-induction hypotension. specifically, it will be investigate how much postinduction hypotension occurs when using a hypotension avoidance strategy - combining continuous intraarterial blood pressure monitoring, careful administration of anesthetic drugs, and continuous administration of norepinephrine to treat hypotension - in high-risk patients having elective non-cardiac surgery.

hypotension is common in patients having non-cardiac surgery with general anesthesia and is associated with organ injury. about one third of hypotension occurs "postinduction" - i.e., after the induction of general anesthesia but before surgical incision. unmodifiable risk factors for postinduction hypotension include age, male sex, and a high american society of anesthesiologists physical status. however, postinduction hypotension is mainly driven by modifiable factors - specifically, anesthetic drugs that cause vasodilation. vasodilation can be effectively treated with vasopressors, e.g. norepinephrine. it is reasonable to assume that postinduction hypotension is largely avoidable by careful anesthetic and hemodynamic monitoring and management during anesthetic induction. a hypotension avoidance strategy could include continuous intraarterial blood pressure monitoring, careful administration of anesthetic drugs, and continuous administration of norepinephrine to treat hypotension. however, it remains unknown to which extent a hypotension avoidance strategy actually can avoid postinduction hypotension. before testing the effectiveness of hypotension avoidance strategies in large-scale randomized trials it is important to investigate their efficacy. in this clinical proof-of-concept study, the aim is to investigate the efficacy of a hypotension avoidance strategy to prevent post-induction hypotension. specifically, it will be investigate how much postinduction hypotension occurs when using a hypotension avoidance strategy - combining continuous intraarterial blood pressure monitoring, careful administration of anesthetic drugs, and continuous administration of norepinephrine to treat hypotension - in high-risk patients having elective non-cardiac surgery.

Eligibility criteria:
inclusion criteria: * american society of anesthesiologists physical status classification iii or higher, and in whom intraarterial blood pressure monitoring is planned for clinical indication exclusion criteria: * emergency surgery * transplant surgery * history of organ transplant * sepsis * pregnancy * contraindications for the use of propofol * rapid sequence induction

Keywords: hypotension low blood pressure anesthesia induction surgery