Kornimate/medical-research-clean huggingface dataset:
hearing aid impact on chronic tinnitus patients evaluated by resting state pet.

Conditions: Chronic Tinnitus

Summary: using resting state positron emission tomography (pet), our goal was to analyze the metabolic and functional neural changes that occur after 6 months of effective hearing aid (ha) use. besides, we correlate those changes with behavioral results. patients with chronic tinnitus and untreated sensorineural hearing loss were tested pre-ha fitting, and at 6 months post-ha fitting.

subjects are selected as they are enrolled in the tinnitus research group between january 2014 and september 2018. the study was approved by the local medical ethics committee for research at the medical school of university of são paulo - protocol number 611.174 in april, 2014. all the procedures were performed after medical evaluation and a complete tinnitus evaluation protocol, which included somatosensory assessment, self-related questionnaires for tinnitus and hearing: tinnitus handicap inventory (thi), hearing handicap inventory for adults (hhia), and , for anxiety and depression symptoms: generalized anxiety depression scale (gad-7) and patient health questionnaire (phq-9), and for neck pain (neck disability index, ndi). the subjects of this study were also blood tested for pregnancy and diabetes, which may interfere on fluorodeoxyglucose (fdg)-positron emission tomography pet acquisition. all subjects underwent hearing and tinnitus evaluation, counseling and hearing aid fitting. to prescribe and verify acoustic response, we used the ha fitting protocol recommended by the national acoustics laboratories (nal), named nal nl-2 (nl-non linear) fdg-pet measurements were obtained at baseline (prior to ha fitting) and after 6 months of ha use. regarding fdg-pet images, a within-subject analysis was performed by comparing pre-treatment and post-treatment group using paired-t-tests.

Eligibility criteria:
inclusion criteria:: 1. chronic perception of tinnitus for more than 6 months; 2. thi score greater than 38; 3. bilateral and symmetric hearing loss not exceeding 70 decibels (db) hearing threshold; 4. no previous experience with ha. - exclusion criteria: 1. unilateral, mixed or conductive hearing loss; 2. pulsatile or myoclonic tinnitus;; 3. anxiety and depression detected by gad-7 and phq-9; 4. significant visual, motor or cognitive deficits; 5. pregnant women and diabetic patients 6. history of drug abuse -

Keywords: hearing loss tinnitus neuroimaging hearing aids positron emission tomography - pet
hormone therapy immediately after histological diagnosis of breast cancer

Conditions: Hormone Dependent Neoplasms; Breast Cancer Female

Summary: breast cancer is a public health issue worldwide. the time from diagnosis to treatment initiation varies from country to country and regionally within a country. early diagnosis and prompt treatment initiation are key factors in patient survival rates. currently there is a rising trend, with a high percentage of patients with "luminal" like breast cancer only undergoing adjuvant endocrine therapy. authors argue that tumor biology alterations after introducing very early endocrine therapy might have a prognostic and therapeutic impact and should be studied.

selected patients of female gender, above 50 y.o, and after a biopsy of luminal-like breast cancer will go under aromatase inhibitor, from the diagnosis day till the surgical therapy to be decided (if so).in this study are going to be included patients that refuse surgical treatment, remaining this way in an "active surveillance". this last group is going to be randomised in order to recieve hormontherapy plus placebo vs hormontherapy plus acetolisalicilic acid. in this way, authors want to investigate if: 1. st this approach influences the tumor biology 2. nd this approach influences tumor pathologic response and progression free survival. 3. rd it is a valid approach and in which grade, for patients that refuse surgical treatment

Eligibility criteria:
inclusion criteria: menopausal woman of equal or above 50 y.o. with breast biopsy of luminal like breast carcinoma exclusion criteria: * informed consent * \<50 y.o. * pre-menopausal state

Keywords: aromatase inhibitors luminal breast cancer neoadjuvant hormone therapy
the role of cerebral hemodynamics in moyamoya disease

Conditions: Moyamoya; Stroke

Summary: the purpose of this study is to determine if people with moyamoya disease who have insufficient blood flow are at a higher risk for stroke.

moyamoya disease is a rare medical disorder that affects the blood vessels (pipes that transport blood) in the brain. in moyamoya disease, the large blood vessels in the middle of the brain close down over time. the cause of this disorder is unknown. in order to compensate for this narrowing, the body grows new small blood vessels around the blockage. these small branches grow larger (and may be more numerous) to give the disorder its name. "moyamoya" is the japanese term for "puff of smoke" and is used to describe the hazy appearance of these small blood vessels on an angiogram. treatment for moyamoya is difficult because so little is known about the disease. some people never have a stroke while others may have several. it is likely that the strokes are due to insufficient blood flow to the brain. there are surgical procedures that may improve blood flow to the brain, however, these procedures may cause complications and may not always improve the blood flow. the main purpose of this study is to determine if people with moyamoya disease who have insufficient blood flow are at a higher risk for stroke. in this study researchers will learn more about the risks and potential benefits of surgical treatment. this information will help decide if there are people at higher risk for stroke who might benefit from surgery or if there are those at a lower risk who might not benefit. in this study, participants will undergo baseline clinical and laboratory evaluation. measurements of blood flow to the brain and oxygen use will be obtained using by positron emission tomography (pet). participants will be followed for up to 5 years. pet studies will be conducted one and three years after enrollment to determine if blood flow improves over time. participants treated with surgery (at the discretion of their treating physicians) will also be followed for perioperative complications, improvement in blood flow, and long term risk of stroke.

Eligibility criteria:
inclusion criteria: * adult \> 18 years of age * capable of informed consent * clinical: both asymptomatic and symptomatic patients will be included. * anatomic: unilateral or bilateral imaging findings consistent with moyamoya collaterals (suzuki stages 3 and 4) on digital subtraction, computed tomographic, or magnetic resonance angiography (after suzuki and kodama, 1983) exclusion criteria: * any other disease that might be responsible for the vasculopathy, including atherosclerosis, neurofibromatosis, meningitis, sickle cell disease, skull base radiation therapy. * pregnancy: all women of child-bearing potential will be tested for pregnancy on the day of the enrollment and throughout the course of the study. * surgery: prior open or endovascular revascularization procedures, unless there have been ischemic symptoms since surgery and angiographic evidence that the procedure was not successful

Keywords: moyamoya stroke
safety and efficacy of xoma 052 in subjects with type 2 diabetes mellitus on stable metformin monotherapy

Conditions: Type 2 Diabetes Mellitus

Summary: the study hypothesis is that xoma 052 improves glycemic control in subjects with type 2 diabetes. study x052078 is designed to establish efficacious dose(s) for future studies based on improvement in hba1c.


Eligibility criteria:
inclusion criteria: * diagnosed with t2d (disease duration ≥ 6 months) * hba1c ≥ 6.8% and ≤ 10.0% * have been on a stable regimen of metformin monotherapy for at least 12 weeks prior to day 0 * willingness to maintain stable diet and exercise regime throughout the study * willingness to maintain current doses/regimens of vitamins and dietary supplements through the end of the study exclusion criteria: * uncontrolled hypertension * history of malignancy within 5 years * history of allergic or anaphylactic reactions to humanized or murine monoclonal antibodies * advanced stage heart failure (new york heart association \[nyha\] class 3 or 4) * clinically significant uncontrolled arrhythmias * history of tuberculosis * active leg, foot, or decubitus ulcer * any significant inflammatory, rheumatologic, or systemic autoimmune disease * history of chronic infections * history or any symptoms of a demyelinating disease * major surgery within 3 months * female subjects who are pregnant, planning to become pregnant other protocol-defined inclusion/exclusion criteria may apply

Keywords: diabetes type 2 mellitus
preserve-zenith® iliac branch system clinical study

Conditions: Aorto-iliac Aneurysms; Iliac Aneurysms

Summary: the preserve-zenith® iliac branch system clinical study is a clinical trial to study the safety and effectiveness of the zenith® branch endovascular graft-iliac bifurcation in combination with the zenith® connection endovascular stent/connectsx™ covered stent in the treatment of aorto-iliac and iliac aneurysms.


Eligibility criteria:
inclusion criteria: * an aortoiliac or iliac aneurysm of appropriate size * unsuitable distal sealing site for a traditional zenith® iliac leg graft within the common iliac artery exclusion criteria: * less than 18 years of age * inability or refusal to give informed consent * disease considerations that would compromise patient safety or study outcomes * unsuitable arterial anatomy

Keywords: zenith aortoiliac aneurysm iliac aneurysm branch connections endovascular graft graft-iliac bifurcation aneurysm vascular diseases cardiovascular diseases
the effect of post-discharge educatıon provıded vıa tele-nursıng to elderly patıents

Conditions: Tele-Nursing

Summary: purpose: the aim of this study is to evaluate the effect of post-discharge training given via tele-nursing to elderly patients operated for hip fracture on the quality of life and functional independence levels of the patients.

materials and methods: this randomized controlled, pretest-posttest, single-center experimental study was conducted in a hospital between august 2022 and april 2023, with 30 patients in the intervention group and 30 patients in the control group. nursing intervention was administered to the intervention group by three educational online video calls (1st, 2nd and 3rd weeks after discharge), three educational voice phone calls (4th, 5th and 6th weeks after discharge) and it consists of a training booklet with educational content. no intervention was applied to the control group. research data; it was collected using the patient introduction form, sf-36, fim. informed consent was obtained from the patients and caregivers with the permission of the ethics committee and the institution. data analysis was done using chi-square, independent t-test and dependent t-test.

Eligibility criteria:
inclusion criteria: * being 65 years or older * being hospitalized and operated on with a diagnosis of hip fracture as a result of a simple fall/falling from one's own level/osteoporotic fracture * being literate * not having a visual/hearing disability that would hinder communication. * not having a mental disorder (according to the statements of the patients) * having a primary caregiver aged 18 and over who will cooperate throughout the research, * having any of the available technical equipment that allows online calls (phone, tablet, computer, etc.). exclusion criteria: * • having previously broken a hip and been operated on * being bedridden or using walking aids before the current fracture

Keywords: functional independence hip fracture, post-discharge education, telenursing, quality of life.
end-tidal co2 (etco2) and ph in the correct naso-gastric tube placement

Conditions: Gastric Feeding Tube; Blood Gas Monitoring, Transcutaneous; pH

Summary: the laying of a naso-gastric tube is an extremely common event in intensive medicine; although standard naso-gastric tube laying is performed at the patient's bedside, this procedure is not without risk. through the use of methods already used in the clinical field, of daily use, we want to identify the threshold value between tracheal and esophageal etco2 (group a) and the threshold value between gastric and esophageal ph (group b).

numerous methodologies have been evaluated to recognize the correct positioning of ngt at the gastric level, including different clinical techniques (such as gastric auscultation, aspiration of the ngt), ultrasound techniques, etc. actually, the diagnostic gold standard is the thoraco-abdominal anterior-posterior radiography, which is considered the only non-invasive method capable to confirm the correct pose of the ngt at intra-diaphragmatic level. this method, however, even if it is non-invasive, requires the use of ionizing radiation (4 micro-sievert (usv) for radiography) which could be repeated multiple time for the same patient; ngt may need to be repositioned several times during the same hospital stay, increasing patient exposure to ionizing radiation and, potentially, also the health workers exposure. the aim is to identify into the group a the threshold value between tracheal and esophageal etco2 and into the group b the theshold value between gastric and esophageal ph. phase a: etco2 measurement will be collected 1. after intubation, when the tube is inserted into the endotracheal tube, before proceeding with the aspiration of secretions and 2. once the ngt has been inserted, by a probe located at the end of the tube. phase b: ph measurement will be collected at the end of the procedure, once the ngt is inserted, at 1.a distance of 25 cm from the mouth (oesophageal site) and at 2. a distance of 40 cm (gastric site), aspirating the gastric contents and measuring on specific litmus paper.

Eligibility criteria:
inclusion criteria: * adult patients (\> 18 years) * patients male and female * patients intubated by oro- or naso-tracheal way * post-induction curarized patients * fasting patients (from at least 6 hours) exclusion criteria: * patient refusal * patients with known bleeding diathesis / ongoing bleeding * patients at risk of bleeding (defined as thrombocytes \ 2.5, activated partial thromboplastin time (aptt) \> 70 sec) * patients with traumatic brain injury / polytrauma * patients with esophagus-tracheal fistulas or malformations of the ear, nose, and throat (ent) sphere * patients with current or previous radiotherapy of the ent sphere * patients unable to give their informed consent due to language barriers * women who are pregnant

Keywords: naso-gastric tube, etco2, ph
the neuroprotective effect of remote ischemic conditioning in aneurysm coiling therapy

Conditions: Aneurysm

Summary: the overall incidence of dwi positive for thromboembolic events following endovascular treatment of intracranial aneurysms is proximately 50%. whether remote ischemic conditioning was safe and effective to reduce ischemic brain lesions on dwi after endovascular treatment of intracranial aneurysms is still unclear. the investigators' hypothesis is that remote ischemic conditioning is a safe and effective strategy to reduce new ischemic lesions in intracranial aneurysms patients undergoing endovascular treatment.


Eligibility criteria:
inclusion criteria: * age 18 years or older * unruptured brain aneurysm deemed suitable for neuroendovascular repair * normal baseline brain mri * female subjects of childbearing potential have a negative pregnancy test. * signed informed consent prior to entering study exclusion criteria: * dissecting or mycotic brain aneurysm. * planned endovascular vessel sacrifice as the primary modality for aneurysm treatment * severe, sustained hypertension (sbp \> 185 mmhg or dbp \> 110 mmhg) * contraindication for remote ischemic conditioning: severe soft tissue injury, fracture, or peripheral vascular disease in the upper limbs * pre-morbid modified rankin scale score of greater than 1 * patients with a pre-existing neurological or psychiatric disease that would confound the neurological or functional evaluations * patients who are unable to have an mri scan for any reason. * currently participating or previously participated in any investigational drug or device study within 6 months
remote digital care effects in adolescents with type 1 diabetes

Conditions: type1diabetes

Summary: pilot study to evaluate effects of an experimental additional remote digital care (teleduc-diab) to adolescents with poorly controlled type 1 diabetes using digital monitoring platform and educative app

the use of digital technologies for the support and monitoring of diabetes have gradually become essential in recent years. the scientific literature reveals contrasting effects of digital and mobile technologies, both on adolescents with t1d (type 1 diabetes) and on their relatives. while the majority of studies have focused on connected devices for continuous blood glucose measurement, the specific effects of other tools, such as those of mobile patient therapeutic education applications or medical telemonitoring, are to this day still poorly documented or even unknown. the study aim to describe the evolution of the glycemic control of adolescents with poorly controled type 1 diabetes during6 months individual teleduc-diab remote digital care in addition to their conventional follow-up. the medical-educational care (teleduc-diab) consist of: * a personalized intensified remote care with a healthcare professional * mydiabby platform: remote monitoring device integrating a data collection platform and systematized monitoring by alarms * the kidia application = a patient therapeutic education mobile application: developed by the enfance, adolescence et diabète association, is a mobile application that patients can personalize (avatar,...) and help them understand and empower to deal with their diabetes. this project offers original and innovative complementary monitoring: remotely, adapted to the specific needs of adolescents and aimed at improving glycemic control by developing self-efficacy and autonomy in adolescents in the management of diabetes.

Eligibility criteria:
inclusion criteria: * adolescent aged ≥12 and \<18, with primary type 1 diabetes detected for at least 12 months, treated with multi-injection insulin or insulin pump * glycated hemoglobin greater than or equal to 8% for more than 3 months * use a continuous interstitial glucose recording system (cgm) * have at least one parent/guardian with a significant caregiver role in the management of the adolescent's diabetes (as determined by the investigator) participating in the study * have digital media compatible with the digital applications of the teleduc- diab (mobile phone and computer) exclusion criteria: • other pathologies associated with diabetes which, according to the investigator, could interfere with glycemic control or the management of adolescent diabetes (examples: secondary diabetes, cystic fibrosis, down syndrome; transplants, corticosteroid therapy, etc.)

Keywords: glucose control patient therapeutic education mobile application remote digital care adolescents teenagers
food as medicine study

Conditions: Nutrition Disorders

Summary: the purpose of this study is to demonstrate proof of concept that registered dietitian nutritionists (rdns) can implement a food as medicine program that utilizes a grocery e-commerce platform in a food retail setting, and the process of measuring the outcomes is feasible.

the academy of nutrition and dietetics data science center (dsc) will implement the proposed prospective feasibility study. the study aims to measure change in nutrition problems, eating patterns, food purchasing patterns and health outcomes of participants who have agreed to receive a 6-month rdn-led food as medicine intervention program in the food retail setting. the intervention will be provided to all study participants and change will be evaluated in participants by comparing data at baseline and endline. the food as medicine intervention program will consist of: * personalized nutrition counseling (delivered in-person or telehealth, depending on preferences of the participant) by hy-vee rdns. * personalized meal plans (based on program participants' individual anthropometrics, disease state, health goals, culture, food allergies / intolerances and eating preferences). the meal plans will be generated by the nutrition technology software, nutristyle. * personalized shopping lists generated by a nutrition technology software (nutristyle) and utilized for in-store grocery shopping, online grocery pick-up or online grocery delivery.

Eligibility criteria:
inclusion criteria: 1. 18+ years old 2. household/participant willing to utilize the shopping list provided 3. no new medical diagnoses or medications (unrelated to the study intervention) within the last 3 months and no anticipated changes during the intervention period. (the participant may have a new medical diagnosis for which they are seeking mnt.) 4. nebraska or iowa resident 5. minimum of one new self-reported diagnosis or an existing diagnosis that participant has not sought mnt for previously: overweight/obesity, hypertension, cardiovascular disease, pre-diabetes, type 2 diabetes 6. first visit with the rdn for the current medical diagnosis (may have received mnt for other conditions previously) 7. access to hy-vee aisles online and nutristyle, through the computer or mobile app 8. willing to use hy-vee's aisles online e-commerce platform and nutristyle 9. willing to meet with a hy-vee rdn regularly in person or via telehealth (and talk on the phone with the hy-vee rdn monthly) throughout the study intervention (6 months) 10. current hy-vee fuel saver card holder, or willing to obtain a fuel saver card 11. provide verbal and written communication and written informed consent in english exclusion criteria: 1. prescribed or taking over-the-counter weight loss medication at enrollment 2. prescribed corticosteroids or other drug known to interfere with glucose metabolism 3. scheduled for bariatric weight loss surgery during 6-month study intervention period 4. pregnant/lactating 5. currently working with another nutrition care professional

Keywords: dietitian feasibility e-commerce