Kornimate/medical-research-clean huggingface dataset:
investigation of the efficacy of internal and external perturbation exercises on functional parameters in stroke rehabilitation

Conditions: Stroke

Summary: stroke is a serious medical condition that causes the death of brain cells as a result of blockage of a blood vessel that feeds the brain (ischemic stroke) or bleeding in or around the brain (hemorrhagic stroke). people who have had a stroke have a higher risk of falling than people who have not had a stroke at the same age. lack of balance control not only increases the risk of falling, but also leads to fear of falling and reduces the integration of people with stroke into society. the central nervous system uses two main postural strategies to maintain and restore balance when perturbed. these; are anticipatory and compensatory postural adjustments. anticipatory postural adjustments control the position of the body's center of mass by activating the trunk and leg muscles prior to a forthcoming body perturbation, thus minimizing the risk of loosing equilibrium. compensatory postural adjustment are initiated by sensory feedback signals and serve as a mechanism of restoration of the position of the center of mass after a perturbation has already occurred. in this study, the investigators aimed to determine which one is more effective, unlike previous studies that showed that internal and external perturbation exercises were effective when applied together. for this purpose, the researchers the planned to investigate and compare the effects on balance, performance, activity and participation in individuals to whom only internal perturbations were applied and only external perturbations were applied. the participants will be divided into 2 groups, as group a and group b, with 10 participants in each group, in a randomized controlled manner. treatment protocol: conventional treatment was applied to participants included in both groups for 4 weeks, 5 days a week, 40-minute sessions. in addition to conventional treatment, 30 minutes of perturbation-based balance training was given to the participant in the study. participants in group a received internal perturbation training, and participants in group b received external perturbation training.


Eligibility criteria:
inclusion criteria: * unilateral stroke history * adults with chronic stroke (\>6 months poststroke) * ability to stand for at least 30 seconds without support exclusion criteria: * those with parkinson's disease, amputation, severe osteoporosis * those with uncontrolled diabetes, hypertension * in addition to stroke, the presence of any problem that may adversely affect balance * areas below 24 in the mini mental state test
palliative care needs among elderly people at emergency department

Conditions: Palliative Medicine; Palliative Care; Elderly Person

Summary: aim: to assess what proportion of all patients over the age of 75 who seek care at the emergency department have palliative care needs and whether these are documented in the patient's medical record. data collection and analysis: patients over 75 years of age who seek care in an emergency department and are classified as triage 2-4 during initial triage are assessed by a researcher. patients with dementia or other cognitive dysfunction will be excluded. two types of data collection are included 1) swedish palliative care guide (s-pcg) documents that the researcher fills in together with the patient, 2) data from the patient's medical record, this data is collected according to a special assessment template. data from the medical record will be collected after the patient left the emergency department. data collection is ongoing until 300 patients have been included in the study. data will be analyzed using descriptive statistics. implications: the percentage of previously undetected/documented palliative care needs in emergency departments is relevant for prioritizing general palliative care within e.g. housing for the elderly and primary care s-pcg can be relevant to increase the level of knowledge at these care facilities. if it turns out that many patients have palliative care needs that are not met in the emergency department, health care structures need to ensure that these patients receive help at the right level of care. this would likely mean that the number of emergency visits and hospital admissions (with suffering and reduced quality of life as a result) can be reduced.


Eligibility criteria:
inclusion criteria: * classified as triage 2-4 exclusion criteria: * dementia or other cognitive dysfunction * not being able to communicate in swedish.

Keywords: elderly palliative care needs emergency department swedish palliative care guide
pilot study comparing taliderm™ dressing versus standard of care for open incision and drainage of wounds

Conditions: Wounds

Summary: to evaluate wound healing with the use of taliderm™ dressing and compare it to wet to dry dressing in the treatment of open wounds after incision and drainage.


Eligibility criteria:
inclusion criteria: * inpatients with soft tissue abscess that will result in an open surgical wounds greater than or equal to 4 cms in any dimension * wound will require serial dressing changes * greater than or equal to 18 years of age * ability to obtain informed consent exclusion criteria: * inability to obtain informed consent * pregnancy * prisoner

Keywords: soft tissue abscess requiring incision and drainage
skin incision adhesive in pediatrics

Conditions: Wounds

Summary: the purpose of this study is to evaluate the effectiveness of on-label use of surgiseal™ tissue adhesive, a cyanoacrylate-based surgical topical skin tissue adhesive in wound closure of the topical skin in children presenting in the emergency department (ed).

subjects had surgiseal™ applied to their topical skin incisions in the ed. subjects' wounds were evaluated for bleeding and closure of the incision/wound before patient discharge and 48 hours after the procedure. further follow up wound closure evaluations were conducted via telephone interview at 5-10 days and 14 days after the ed visit.

Eligibility criteria:
inclusion criteria: * between the ages of 5 and 18 years of age, inclusive * candidate for use of a topical surgical skin adhesive * informed consent by a parental guardian exclusion criteria: * a wound with evidence of active infection or gangrene or wounds of decubitus etiology * mucosal surfaces or across mucocutaneous junctions or skin that might be exposed to body fluids or dense natural hair * subjects with known hypersensitivity to cyanoacrylate or formaldehyde

Keywords: pediatric wounds
study of ono-4538 in gastric cancer

Conditions: Gastric Cancer

Summary: the purpose of study is to evaluate the efficacy and safety of ono-4538 with chemotherapy in unresectable advanced or recurrent gastric cancer (including esophagogastric junction cancer) not previously treated with the first-line therapy. part 1 is intended to evaluate the tolerability, safety, and efficacy of ono-4538 in combination with sox therapy (tegafur / gimeracil / oteracil potassium + oxaliplatin) or capeox therapy (capecitabine + oxaliplatin). in part 2, the investigator or the subinvestigator will choose a chemotherapy (sox or capeox therapy), taking into account the condition of each subject. part 2 is planned to evaluate the efficacy and safety of ono-4538 + chemotherapy in comparison with placebo + chemotherapy.


Eligibility criteria:
inclusion criteria: * patients with unresectable advanced or recurrent gastric cancer (including esophagogastric junction cancer) that has not been treated with the first-line therapy with systemic antitumor agents for advanced or recurrent gastric cancer (including esophagogastric junction cancer) * have measurable lesions as defined in recist guideline version 1.1 * ecog ps score 0 or 1 * have a life expectancy of at least 3 months exclusion criteria: * have multiple cancers * have a current or past history of severe hypersensitivity to any other antibody products * patients with any metastasis in the brain or meninx that is symptomatic or requires treatment * patients with active, known or suspected autoimmune disease
post infarction exercise effects on myocardial function assessed by 2d strain ultrasound

Conditions: Myocardial Infarction

Summary: the main goal of our project is to study and describe the effect of exercise training on systolic and diastolic myocardial function assessed by 2d ultrasound strain after myocardial infarction. our working hypothesis is that the intrinsic myocardial contractility and relaxation assessed by global longitudinal strain in phase ii (or 2d strain) during post-infarction exercise training will be improved compared to baseline values as well as compared to values in a no-training group. should this hypothesis prove true, it would help explain the improvements in functional capacity observed during the post-infarction period and after exercise training.


Eligibility criteria:
inclusion criteria: * the patient must have given his/her informed and signed consent * the patient must be insured or beneficiary of a health insurance plan * the patient is available for 4 months of follow-up * the patient had a first myocardial infarction episode (within the past 3 months) requiring medical treatment or revascularisation (e.g. balloon angioplasty) or aortocoronary bypass exclusion criteria: * the patient is simultaneously participating in (or has participated in the past 3 months) another interventional study * the patient is in an exclusion period determined by a previous study * the patient is under judicial protection or under guardianship * it is impossible to correctly inform the patient or the patient refuses to sign the consent * the patient is pregnant, parturient, or breastfeeding * contra indication for exercise training * valve prosthesis * severe valvular disease * pacemaker * heart transplant * non sinus rhythm
will adjusting the ph of lidocaine reduce the pain during injection of local anaesthetic?

Conditions: Needlestick Injuries

Summary: this study will investigate the influence of adjusting the ph of lidocaine on pain during subcutaneous injection. each participant will receive two injections on the abdomen with different ph. after each injection, the subject will be asked to evaluate the pain on a visual analog scale (0-100 mm). it is anticipated that the pain decreases with increasing ph. the aim of the study is to find a simple method for pain reduction that can be used in clinical practice.


Eligibility criteria:
inclusion criteria: fyll inn * age 18-65 years exclusion criteria: * kidney, heart or liver disease * eczema or psoriasis on injection site * neuropathy * regular use of painkillers * hypersensitivity of lidocaine * pregnancy * diabetes

Keywords: pain injections lidocaine healthy volunteers
a pilot study of recombinant human relaxin (rhrlx) in compensated congestive heart failure

Conditions: Heart Failure, Congestive

Summary: this trial is a single center, open-label, dose-finding study of recombinant human relaxin (rhrlx) given intravenously (iv) to patients with stable, compensated chf.

serial cohorts of patients with stable chf will be enrolled upon meeting eligibility criteria. dose escalation will be guided by hemodynamic response, safety and tolerability. the effects of rhrlx on hemodynamics will be assessed.

Eligibility criteria:
inclusion criteria: * male and female patients over the age of 18 * new york heart association (nyha) class ii-iii chf * left ventricular ejection fraction (lvef) of \< 35% exclusion criteria: * acute coronary syndrome * acute decompensated chf * hypotension * recent significant arrhythmia * recent stroke * significant renal or hepatic impairment * pregnancy or child-bearing potential

Keywords: congestive heart failure relaxin cardiac hemodynamics
vascular endothelial function and cardiac resynchronization response in patients with heart failure

Conditions: Heart Failure

Summary: the purpose of this research study is to determine the role of blood vessel endothelial function in heart failure and the effect of cardiac resynchronization therapy (crt) on heart and endothelial function.


Eligibility criteria:
inclusion criteria: * crt group: patients recommended for crt-p or crt-d for heart failure (hf) according to current american heart association (aha)/american college of cardiology (acc)/heart rhythm society (hrs) guidelines of left ventricle ejection fraction (lvef)\ 120 ms, new york heart association (nyha) class ii-iii). * control group: patients who undergo device (pacemaker or icd) implantation or a pack change for sinus node dysfunction or av blocks exclusion criteria: * patients who are unwilling or unable to return for follow up visits 3 months after device implantation.
strength testing after nitrate delivery (stand) in icu patients

Conditions: Respiratory Failure

Summary: it is well documented that intensive care unit (icu) patients have lower levels of skeletal muscle strength compared to non-icu patients upon hospital discharge, and this weakness affects the patient's ability to perform basic activities of daily living upon hospital discharge and for extended periods thereafter. recently, critically ill icu patients have been shown to have lower nitric oxide levels. these patients often suffer from a disturbed homeostasis with circulatory and metabolic abnormalities that may potentially contribute to their icu acquired weakness. given the recent research showing dietary nitrate supplementation can increase nitric oxide levels and improve exercise tolerance in healthy and diseased older individuals, our aim is to investigate the importance of nitrate supplementation in icu patients with focus on physical function and icu acquired muscle weakness.

the proposed study is an investigator initiated, double blind, placebo controlled experimental study designed to evaluate the effect of chronic no3- supplementation via beetroot juice ingestion on the skeletal muscle strength and physical function in icu patients. patients will be randomized to receive either nitrate rich or nitrate depleted beetroot juice once daily during their icu and hospital stay. physical function and skeletal muscle strength will be measured at icu (± 2 days) and hospital (± 2 days) discharge and 2 months (± 2 weeks) after enrollment. plasma levels of nitrate and nitrite will be measured 1, 3 and 5 days after randomization into the trial and at icu and hospital discharge. skeletal muscle ultrasound will be performed to examine the size and echogenicity of patient muscles. self-reported physical function will be measured using the functional performance inventory short form (fpi-sf). the fpi-sf provides an overall score of patient self-reported functional performance in the areas of household maintenance, movement, family and social activities, work, avocation and recreation

Eligibility criteria:
inclusion criteria: * age \> 55 years * mechanically ventilated via an endotracheal tube or mask who have begun spontaneous breathing trials or extubated within the previous 24 hours * lung injury as defined by a pao2 / fio2 \< 300 exclusion criteria: * inability to walk without assistance prior to acute icu illness (use of a cane or walkers not exclusions) * cognitive impairment prior to acute icu illness (non-verbal) * acute stroke * body mass index (bmi) \>50 * neuromuscular disease that could impair weaning (myasthenia gravis, als, guillain-barre) * hip fracture, unstable cervical spine or pathological fracture * mechanically ventilated \> 80 hours * current hospitalization or transferring hospital stay \> 7 days * dnr/dni on admission * cancer treatment within the last 6 months * moribund * participation in another research study * on nitroglycerine or nitrate preparations used with angina or phosphodiesterase type 5 inhibitors * body mass less than 60 kg

Keywords: icu respiratory failure weakness nitrate supplementation
mobility of vulnerable elders (move): translating knowledge to health care aides in long-term care facilities

Conditions: Mobility Limitation

Summary: almost 90 percent of residents living in long-term care facilities have some type of mobility limitation, which worsens quickly once they move into a long-term care facility. this means that they cannot easily walk or move around in their day-to-day lives and this can have serious consequences for their general health and well-being. researchers have shown that exercise can help the mobility of even the oldest of adults but elderly residents in long-term care facilities still commonly sit or lie in bed for long periods of time, in many cases for most of their waking hours. the purpose of this research is to study the effect of a simple physical activity on the mobility and quality of life of residents in long-term care facilities. researchers will introduce a sit-to-stand activity to health care aides which will become part of their daily routine with residents. the basic sit-to-stand movement is already a part of the daily activities that health care aides do with residents. specifically, health care aides will ask residents to repeat the sit-to-stand activity at mealtimes, when using the toilet, and on other occasions of daily activity. an important part of this research is to find out how well the activity preserves the ability of residents to stay mobile and also to examine how this will improve their quality of life in the home. the move study will demonstrate whether it is possible to delay the loss of mobility in long-term care residents by incorporating the sit-to-stand activity into the regular practice of health care aides.


Eligibility criteria:
inclusion criteria: * have a diagnosis of alzheimer disease, vascular dementia, or mixed dementia * are able to transfer independently or with the assistance of one person exclusion criteria: * have a diagnosis of fronto-temporal or lewy-body dementia * require the assistance of more than one person to transfer, or a transfer lift

Keywords: aging health services knowledge translation long-term care facilities mobility psychosocial and health behaviours
neuropathic pain in patients with cancer

Conditions: Neuropathic Pain

Summary: the purpose of this study is to collect beginning information on whether intravenous (iv) administration of krn5500 is safe and effective for treatment of neuropathic pain in patients with cancer.

neuropathic pain is a type of pain that results from nerve damage and is characterized by an abnormal hypersensitivity to harmless as well as harmful stimuli. this type of pain is extremely difficult to manage, fails to respond to standard analgesic medications or interventions, and often gets worse instead of better over time. current approved therapeutic agents often have intolerable side effects and limited efficacy. thus, there is an urgent need to develop safe and effective drugs to treat neuropathic pain. study dtcl100 will be conducted at multiple centers and will enroll patients that have advanced cancer and neuropathic pain that has not responded well to previous treatment. eighteen patients will be randomly assigned to receive up to 8 doses of active drug (krn5500) or placebo. a maximum of 8 doses will be administered weekly over a 10 week period. patients are encouraged to complete at least 4 treatment visits before a decision is made to complete the full 10 weeks of treatment and the 1 month followup period.

Eligibility criteria:
inclusion criteria: * 18 years or older * diagnosis of advanced or recurrent cancer * no options for curative chemotherapy, but palliative chemotherapy allowed under certain conditions * refractory neuropathic pain rated 4 or greater on 0-10 scale and failure to respond to 2 commonly used treatments * if taking opioids for pain, stable regimen over past week before enrolling * karnofsky performance status of 40 or more * females must be sterile or post-menopausal exclusion criteria: * radiation to site of neuropathic pain for past 4 weeks * major surgery within past 2 weeks * liver function and other key labs outside normal parameters * ecg showing significant abnormality * myocardial infarction (heart attack) within past 6 months * history of interstitial lung disease * history of severe allergic reaction to drugs containing polysorbate 80 * other investigational drug within 2 weeks or 5 half-lives (whichever is longer

Keywords: neuropathic pain cancer
risk analysis for cardiovascular autonomic neuropathy

Conditions: Cardiovascular Autonomic Neuropathy

Summary: this is a large-scale, community-based, cross-sectional study to evaluate environmental and genetic risk factors for cardiovascular autonomic neuropathy in general chinese population.

a large-scale, community-based, cross-sectional study was conducted to explore the extent to which risk factors associated with cardiovascular autonomic neuropathy (can) in general chinese population. a total of more than 2000 participants were recruited by using multiple stages sampling (first cluster sampling and then simply sampling). data involved in demographic information, clinical biomarkers such as glucose and lipids profiles, medical and therapy history were collected. every participants was complete dna extracted and genotyped. cardiovascular autonomic functions were measured by using short-term heart rate variability (hrv) to evaluate the outcome of can. univariate and multiple variables analysis have been performed to examine potential environmental and genetic risk factors of can. in addition, clinical risk model, simply screening model and non-linear system model such as artificial neural network was created, respectively.

Eligibility criteria:
inclusion criteria: * survey chinese participants with undiagnosed can * aged 30-90 years, were included in this study. exclusion criteria: * some subjects were excluded from the study to eliminate potential confounding factors that may have influenced their ca function. briefly, the exclusion criteria were as follows: 1. history or findings of arrhythmia and hyperthyroidism or hypothyroidism 2. pregnancy or lactation 3. serious hepatic or renal dysfunctions (gfr \< 30 ml/min/1.73m2). * of these subjects, complete baseline data were obtained for 2,092 (69.46%) of the participants.

Keywords: risk analysis general chinese population cardiovascular autonomic neuropathy
procalcitonin level and the high risk of mortality in 30 days in severe acute respiratory syndrome coronavirus 2 (sars-cov-2) patient , cases series.

Conditions: the Relationship Between Procalcitonin and 30-day Mortality in COVID Patients

Summary: background: procalcitonin (pct) is a biomarker that has been proposed as a helpful tool in inflammatory clinique cases specially patient with pulmonary bacterienne infection . materials and methods the investigatore had retrospectively reviewed the electronic records and lists of all 582 covid-19 patients admitted on the icu of hospital university mohammed vi , oujda. between 01 juin 2020 and 31juanary 2021 , and analyzed the relation of pct value and mortality at 30 days until we can defined a cut off procalcitonine to use as a marker of severity and high mortality .

our objective is to assess the relationship between procalcitonin and 30-day mortality in patients admitted to the resuscitation department of the mohammed vi university hospital center, oujda, morocco, infected by the sars cov 2 virus .

Eligibility criteria:
inclusion criteria: * clinical diagnosis of sars cov2 infection needed admission in icu . exclusion criteria: * patient under 15 ans

Keywords: covid procalcitonine mortality