Kornimate/medical-research-clean huggingface dataset:
the effect of dry heat and dry cold application on blood sampling in children

Conditions: School Age Children; Blood; Procedural Pain; Procedural Anxiety; Fear

Summary: the study was conducted as a parallel group randomized controlled in order to determine the effects of dry heat and dry cold application before blood collection in school-aged children (7-12 years old) on pain, anxiety and fear levels. participants were randomly assigned to experiment 1-dry hot application group, experiment 2-dry cold application group and control group. in experiment 1-dry heat application group, a dry heat of 42°c was applied to the determined area with an electrical heating pad for 5 minutes before blood sample was taken. in experiment 2-dry cold application group, dry cold was applied to the area determined with a gel pad for 3 minutes before blood sample was taken. in the control group, blood sampling was performed according to the clinical routine, and no heat or cold application was made.

prior to blood sampling, parents and children were initially informed about the study in experiment 1-dry heat, experiment 2-dry cold, and control groups, and their written and verbal consents were obtained. after obtaining consent, information about the child and family was collected by the researcher with the "child-family introductory information form" before the procedure. after the family and the child were introduced to the measurement tools (wong baker faces pain scale, child fair anxiety scale and medical procedures fear inventory) to be scored, it was explained to the child that his mother or father would be with him during the procedure, and he was taken to the intervention room. before the blood sample collection, the child's fear and anxiety were evaluated using child fear anxiety scale. in experiment 1-dry heat application group, the electrical heating pad with temperature regulation was heated by the researcher and set to 42°c. after making sure that there were no contraindications (deterioration of skin integrity, etc.) in the application of the electrical heating pad device, a dry heat of 42°c was applied to the determined area with an electrical heating pad for 5 minutes. in experiment 2-dry cold application group, dry cold was applied to the determined area with a gel pad for 3 minutes after the researcher made sure that there were no contraindications (deterioration of skin integrity, etc.) in the application of the gel pad. in the control group, blood sampling was performed according to the clinical routine, and no heat or cold application was made.

Eligibility criteria:
inclusion criteria: * 7-12 years old * absence of physical and mental illness * absence of auditory, visual and verbal speech disability * parents' willingness to participate in the research, and signing the volunteer form exclusion criteria: * those who do not meet the inclusion criteria * those who do not volunteer to participate

Keywords: blood sampling children dry heat dry cold pediatric nurse
pregabalin peripheral neuropathic pain study

Conditions: Diabetic Neuropathies; Neuralgia

Summary: to evaluate the efficacy of pregabalin, using a flexible, optimized dose schedule with dose adjustment based on daily pain rating scale (dprs), compared to placebo in subjects with peripheral neuropathic pain.


Eligibility criteria:
inclusion criteria: * diagnosis of peripheral neuropathic pain syndrome, including diabetic peripheral neuropathy (dpn), postherpetic neuralgia (phn), or post-traumatic neuropathic pain (including post-surgical), confirmed by a qualified pain specialist. * subjects must have completed at least 4 daily pain diaries during the 7 days prior to visit 2 and have an average pain score of ≥4 over the 7 days prior to visit 2 (randomization). exclusion criteria: * neurologic disorders unrelated to dpn, phn, or post-traumatic neuropathic pain (including post-surgical), that may confuse or confound the assessment of neuropathic pain. * presence of any severe pain associated with conditions other than dpn, phn, or post-traumatic neuropathic pain (including post-surgical) that may confound the assessment or self evaluation of the pain due to dpn, phn, or post-traumatic neuropathic pain (including post-surgical). * creatinine clearance \< 30 ml/min (estimated from serum creatinine, body weight, age, and sex using the cockcroft and gault equation in appendix e). maximum dose for subjects with creatinine clearance of 30 to 60 ml/min is 300 mg/day
fmt in the treatment of ibs

Conditions: Irritable Bowel Syndrome

Summary: 52 adult ibs patients were recruited. 50% were given a fecal microbiota transplantation in colonoscopy and 50% were given an fmt made of their own feces as placebo. follow up time was 1 year after fmt.

52 adult ibs patients of any subgroup(ibs-d, ibs-c or ibs-m), were recruited and given an fmt in colonoscopy. neither the patient nor the care taking personnel did know in which group the patients belonged to. the patients were screened with fecal samples for 16rna sequencing and they were repeatedly done ibs-sss questionnaire and questionnaires for quality of life and psychical condition. follow up time was 1 year after the colonoscopy.

Eligibility criteria:
inclusion criteria: * diagnosis of ibs based on rome iii criteria * having received traditional treatment for at least 1 month * availability of consecutive fecal samples over one year. * compliance to attend ileocolonoscopy and fmt procedure. * 18-75 years exclusion criteria: * unable to provide informed consent * antibiotic therapy in past 3 months * inflammatory bowel disease (ibd)
exploratory study on the role of somatic modulation in hyperacusis

Conditions: Hyperacusis

Summary: this study focuses on patients with a primary complaint of hyperacusis. hyperacusis has been defined as 'abnormally reduced tolerance to sound' and is commonly associated with tinnitus. the effects of somatic modulation upon tinnitus have been studied, but not so for hyperacusis.. the effect of 9 somatic modulations (i.e. 3 jaw modulations and 6 cervical spine modulations) and 1 control movement (i.e. without any somatic modulation effect) in random order on the sound tolerance of a 1 kilohertz (khz) broadband noise sound and the tinnitus experience will be investigated. more specifically, the perceived loudness and intrusiveness of this sound and the tinnitus sound will be evaluated before somatic modulation and during the somatic modulation.


Eligibility criteria:
inclusion criteria: * primary complaint of hyperacusis exclusion criteria: * primary complaint of tinnitus

Keywords: hyperacusis somatic modulation
imaging study to investigate the safety and diagnostic performance of rhpsma 7.3 (18f) in newly diagnosed prostate cancer.

Conditions: Prostate Cancer

Summary: a prospective, phase 3, multi center, single-arm, imaging study investigating the safety and diagnostic performance of radio-hybrid prostate specific membrane antigen (rhpsma) 7.3 (18f) positron emission tomography (pet) ligand in men with newly diagnosed prostate cancer.

main objective is to assess the sensitivity and specificity of rhpsma-7.3 (18f) positron emission tomography (pet) in detecting n1 disease (as determined by the central blinded image evaluation \[bie\]) on a patient level compared to the histopathology of pelvic lymphatic tissue removed during radical prostatectomy (rp) and pelvic lymph node dissection (plnd). at least one positive pelvic ln on pet (n1) and one positive lymph node (ln) as determined by histopathology (pn1) on the same side of the pelvis (left or right) will be deemed a true positive (tp) at the patient level.

Eligibility criteria:
inclusion criteria: 1. patient is male and aged \>18 years old. 2. histologically confirmed adenocarcinoma of the prostate. 3. patients electing to undergo radical prostatectomy (rp) with pelvic lymph node dissection (plnd). exclusion criteria: 1. patients who are planned to have an x-ray contrast agent or other pet radiotracer \<24 hours prior to the pet scan. 2. patients currently receiving, or with a prior history of, androgen deprivation therapy (adt).

Keywords: primary prostate cancer diagnostic prostate specific membrane antigen (psma) positron emission tomography (pet) scan
torsion of the tibial tuberosity, a new factor of patellar instability?

Conditions: Patellar Instability; Patellar Dislocation

Summary: patellar instability (recurrent patellar dislocation) can occur at any age. it is most often seen in young subjects, especially among adolescents. it is commonly accompanied by anatomical factors. a new factor not described in bibliographic sources and characterized by an external torsion of the tibial tuberosity is frequently found in patients with patellar instability thanks to mris. this does not seem to be the case when there is no patellar pathology. a statistical study is needed to assess this rotary anomaly. validate the predictive benefits when measuring the torsion of tibial tuberosity in cases with recurrent patellar dislocation.

patellar instability (recurrent patellar dislocation) can occur at any age. it is most often seen in young subjects, especially among adolescents. it is commonly accompanied by anatomical factors known to be driving: dysplasia of the trochlea, patella alta, lateralisation of the tibial tuberosity, patellar torsion and misalignment, tearing of the medial patello femoral ligament... the assessment of these factors is essential to evaluate the instability and guide the procedures of the surgical treatment. mris have become an important test for the analysis and measurement of these factors. a new factor not described in bibliographic sources and characterized by an external torsion of the tibial tuberosity is frequently found in patients with patellar instability thanks to mris. this does not seem to be the case when there is no patellar pathology. a statistical study is needed to assess this rotary anomaly. it will be necessary to take it into account in the future regarding indications and techniques for tibial tuberosity osteotomies, often used to correct patellar instability.

Eligibility criteria:
inclusion criteria: * men or women * subjects who have not expressed opposition to the use of the data for research purposes clinical criteria: * unstable group: * medical history with 2 patellar dislocations or more, * with or without requiring surgical treatment after an mri control group: men or women over 18 years old * subjects who have not expressed opposition to the use of the data for research purposes * control group: * patients showing meniscal injury on mri who may or may not have been treated (meniscectomy or stitches) exclusion criteria: * unstable group: * mri performed on one knee operated for patellar instability * associated tearing of the ligament (acl, pcl) * control group: * patients with a medical history of patellar pathology * patients with associated ligament injury (acl, pcl)

Keywords: torsion of tibial tuberosity recurrent patellar dislocation mri measurements patellar instability patellar dislocation tibial tubercle position tibial tubercle torsion
immunohistochemical expression of epithelial cell adhesion molecule (epcam) in epithelial ovarian carcinoma

Conditions: Ovarian Carcinoma

Summary: cancer stem cells (cscs) can undergo self-renewal and differentiation. epcam is a 40-kda type i transmembrane glycoprotein composed of a large extracellular domain, one transmembrane region, and a small intracellular domain of 26 amino acids. recent insights revealed that it is involved in promoting cancer cell proliferation, migration, and invasiveness. it is used as a diagnostic and prognostic marker. epcam has also recently been identified as a marker for cscs.

ovarian carcinoma is one of most frequent cancer in women worldwide. epithelial ovarian carcinoma is a group of neoplasms with different histologic pictures. serous carcinoma is the most common type. cancer stem cells (cscs) can undergo self-renewal and differentiation. epcam is a 40-kda type i transmembrane glycoprotein composed of a large extracellular domain, one transmembrane region, and a small intracellular domain of 26 amino acids. it is abundantly expressed by the majority of human epithelial carcinomas, including colorectal, breast, lung, prostate, ovarian, and endometrial cancers. it is overexpressed in various neoplasms. recent insights revealed that it is involved in promoting cancer cell proliferation, migration, and invasiveness. it is used as a diagnostic and prognostic marker. epcam has also recently been identified as a marker for cscs.

Eligibility criteria:
inclusion criteria: * patients with epithelial ovarian carcinoma and underwent surgery exclusion criteria: * - cases received pre-operative chemotherapy or radiotherapy. * cases with insufficient clinical data.

Keywords: ovarian carcinoma cscs epcam
neutrophil gelatinase-associated lipocalin: biomarker of acute kidney injury after cardiac surgery

Conditions: Early Acute Kidney Injury

Summary: the following objectives were used for comparison: 1)primary objective: evaluate the urinary excretion of ngal as a marker of early development of acute kidney injury in patients undergoing cardiac surgery.

all patients aged greater than 18 years undergoing elective cardiac surgery for coronary artery bypass grafting and / or valve replacement, in need of cardiopulmonary bypass and with the prospect of minimum hospital length stay of 48 hours in icu, will be candidates for participation in this study. criteria for exclusion patients with ira before hospitalization in the icu; patients with estimated glomerular filtration (mdrd formula simplified) less than 30 ml / min; patients transplanted kidney; patients with chronic renal failure on dialysis; patients anuric the admission in the icu; refusal to participate in the study. definition of ira: ira will be defined according to the new proposal of akin (acute kidney injury network) (awaiting publication): abrupt elevation (48 hours) of serum creatinine in value greater than or equal to 0.3 mg / dl or an increase of 50% compared to baseline or reduction of urinary volume to 0.5 ml / kg / h for more than 6 hours (annex 1). laboratory investigations samples of urine will be collected before surgery, after 2, 4, 6, 12, 24, 48, 72 and 96 hours after the end of the cec for determination of creatinine and urinary ngal (normalization of ngal for excretion urinary creatinine). the serum creatinine is measured before surgery and daily during the first 4 days after surgery for the diagnosis of ira. if the time of cec exceed 2 hours, the first sample of urine after the end of the cec will be considered as "sample 2 hours". quantification of ngal samples of urine will be centrifuged (5 min at 2000 rpm) and frozen at -20 ° c for later determination of ngal by method of elisa (kit commercial antybodyshop, denmark).

Eligibility criteria:
inclusion criteria: * patients aged greater than 18 years undergoing elective cardiac surgery for coronary artery bypass grafting and/or valve replacement * in need of cardiopulmonary bypass and with the prospect of minimum hospital length stay of 48 hours in icu exclusion criteria: * patients with ira before hospitalization in the icu * patients with estimated glomerular filtration (mdrd formula simplified) less than 30 ml/min * patients transplanted kidney * patients with chronic renal failure on dialysis * patients anuric the admission in the icu * refusal to participate in the study. definition of ira: ira will be defined according to the new proposal of akin (acute kidney injury network) (awaiting publication): abrupt elevation (48 hours) of serum creatinine in value greater than or equal to 0.3 mg / dl or an increase of 50% compared to baseline or reduction of urinary volume to 0.5 ml / kg / h for more than 6 hours

Keywords: acute kidney injury ngal cardiac surgery
the effect of education given to patients with atrial fibrillation on anxiety levels

Conditions: Atrial Fibrillation (AF); Atrial Fibrillation New Onset

Summary: this study aims to evaluate the effect of a structured training program on state anxiety levels in patients diagnosed with atrial fibrillation (af). af is a chronic heart rhythm disorder that negatively affects patients' quality of life with both physical and psychological symptoms. lack of information and uncertainty in af patients cause increased anxiety levels, making compliance with treatment difficult. this study aims to determine whether an educational intervention for af patients can reduce their anxiety levels and increase their awareness of the disease. this is a randomized controlled trial. a two-session individual training program containing detailed information about af will be applied to the training group and no training will be given to the control group. data will be collected through a personal information form and the situationality anxiety inventory (stai). hypotheses of the research h0: training regarding atrial fibrillation has no effect on the anxiety level of patients. h1: education regarding atrial fibrillation reduces the anxiety level of patients.


Eligibility criteria:
inclusion criteria: * newly diagnosed with af, * able to speak and understand turkish, * does not have a physical or psychological disorder that would cause communication problems, * patients between the ages of 18 and 65 who are oriented to place and time, -agreeing to participate in the study exclusion criteria: \* using any psychotropic medication (antidepressant, anxiolytic, antipsychotic)

Keywords: anxiety atrial fibrillation patient education
use of erythromycin in mustard-induced bronchiolitis

Conditions: Bronchiolitis Obliterans; Acute Obliterating Bronchiolitis

Summary: we looked for the effectiveness of low-dose long-term prescription of erythromycin in mustard-induced bronchiolitis obliterans


Eligibility criteria:
inclusion criteria: * documented chemical exposure * clinical, spirometric and radiological findings were compatible with bo on high resolution computed tomography (hrct) * non-responsiveness to high dose bronchodilator therapy exclusion criteria: * radiographic evidence of pneumonia, active tuberculosis, lung carcinoma, or an infection that necessitated the use of an antibiotic * history of cigarette smoking and occupational exposure to toxic agents of hypersensitivity to macrolides * history of treatment with a systemic antibiotic within 7 days before the start of the study * any investigational medicine within 4 weeks of the study * history of antibiotic injection within 6 weeks before the study * concomitant theophylline or carbamazepine, unless their serum concentrations were regularly monitored * patients who were in the exacerbation phase of their respiratory complications * need to use medications interact with macrolides such as digoxin, theophylline and carbamazepine * systemic antibiotics * systemic corticosteroids * admission to the hospital * abnormal kidney or liver function
transfer and ultrafiltration in peritoneal dialysis

Conditions: End-stage Renal Disease

Summary: the aim of this study is to demonstrate the efficiency of an adapted and "alternate" peritoneal dialysis scheme in terms of sodium extraction and purification compared to an adapted conventional peritoneal dialysis scheme.


Eligibility criteria:
inclusion criteria: * patients hospitalized in the nephrology department of the besançon university hospital * patients treated by continuous ambulatory peritoneal dialysis or ambulatory peritoneal dialysis for at least 6 months * absence of hospitalization caused by an infection in the month prior to inclusion * patients with a ratio (d / p) of the concentration of creatinine in the blood and dialysate between 0.5 and 0.8 on a checkup of less than 1 year. * no contraindication to the use of hypertonic bag * signature of informed consent for participation indicating that the subject has understood the purpose and procedures required by the study and agrees to participate in the study and comply with the requirements and limitations inherent in this study * affiliation to a french social security system or beneficiary exclusion criteria: * legal incapacity or limited legal capacity * patients unlikely to cooperate in the study and/or low cooperation anticipated by the investigator * patients without health insurance * pregnant women * patient being in the exclusion period from another study or planned by the "national register of volunteers" * hospitalization caused by an infection in the month prior to inclusion * patients with a peritoneal dialysis catheter dysfunction

Keywords: nephrology extra-renal purification peritoneal dialysis
the effect of modified sham feeding with orlistat in overweight and obese subjects

Conditions: Overweight

Summary: the purpose of this study is to determine if the drug orlistat (alli, xenical) decreases the taste for fat in humans.

one screening visit and testing visits 1 and 2: approximately 1-2 hours (fasting - you will have nothing to eat or drink (except water or medications) after midnight before the test visit.) if you qualify for the study, you will return to pennington biomedical research center for the test visit * you will be given a questionnaire to screen for allergies or cold symptoms. * women will answer a questionnaire based on their menstrual cycle. * before eating, you will be given instructions on how to use the study medication. you will swish about 2 teaspoons of a solution in your mouth for 30 seconds and then spit it out (like mouthwash). * just before eating, you will be given another brief questionnaire judging your appetite. * you will be given the test meal. you will be allowed to eat as much or as little as you like during a 20-minute eating period. * 30 minutes after starting your meal you will be given the brief questionnaire again to judge your appetite. * you will return in 1 month to complete test visit 2.

Eligibility criteria:
inclusion criteria: * are a healthy male or female, * are between 18 to 70 years of age, * have a body mass index between 25-35 kg/m2 exclusion criteria: * are a female who is pregnant or nursing, * are a restrained eater (determined using a questionnaire), * have any current illnesses such as an infection, * have any serious medical problems including kidney, liver, heart or lung disease, * use medications known to increase appetite, * are taking any medication that has not been on the same dose for at least 30 days, * dislike the test food.