Kornimate/medical-research-clean huggingface dataset:
alternative care in patients with auto-immune diseases

Conditions: Auto-Immune Diseases

Summary: patients followed in internal medicine bring together favorable conditions for the use of alternative medicines. while some are recognized for their benefits, some can, on the contrary, harm the patient. it is therefore proposed to make a complete descriptive inventory of these practices, through an anonymized questionnaire. the main objective is the evaluation of the proportion of the use of alternative medicines in patients with in the department of internal medicine a

patients followed in internal medicine department bring together favorable conditions for the use of alternative medicines. while some are recognized for their benefits, some can, on the contrary, harm the patient. it is therefore proposed to make a complete descriptive inventory of these practices, through an anonymized questionnaire. the main objective is the evaluation of the proportion of the use of alternative medicines in patients with autoimmune diseases in the department of internal medicine . at all times alternative medicine has existed. internal medicine deals with rare autoimmune diseases, of which there is not always a cure. even when the treatment is optimal, there are often subjective complaints.patients followed in internal medicine therefore have favorable conditions for the use of alternative medicines. while some are recognized for their benefits, some can, on the contrary, harm the patient. it is therefore proposed to make a complete descriptive inventory of these practices, through an anonymized questionnaire. this information will make it possible to target the patient's needs, and to be able to offer alternative medicines that are better focused, without calling into question their conventional treatment

Eligibility criteria:
inclusion criteria: * patient with systemic lupus erythematosus (ara and/or slicc criteria) or with primary sjögren's syndrome (revised americano european criteria) or with systemic scleroderma (acr/eular 2012 criteria) * patient with signed consent exclusion criteria: * patients deprived of their liberty * minors and adults subject to legal protection measures * patients subject to a justice safeguard measure * patient unable to understand or adhere to the protocol
post marketing clinical evaluation assessing the visual performance of hanita lenses "intensity sl" intraocular lens

Conditions: Cataract

Summary: this clinical study will assess the safety and performance of intensity sl iol, 1 year post operation. the study will also evaluate the patient satisfaction of the implanted patients.

study design: this study is an ambispective, single arm single center, open label study. study objectives: the aim of this study is to evaluate performance of hanita lenses intensity sl iol. the primary aim of this study is to evaluate the binocular defocus curve and visual acuity for far, intermediate and near distance after intensity sl iol implantation. the second aim of this study is to evaluate the patient satisfaction 12 to 24 months post-operation. study population: men and women who had implantation on both eyes using hanita lenses seelens sl iol, for 12 to 24 months post operation. enrollment: the study will encompass a total of 60 eligible subjects implanted bilaterally (120 eyes) in total who will complete the protocol follow-up schedule. duration of subject participation: duration of subject participation is at most one month completion of active enrolment is anticipated to last approximately 6 months. the primary aim will be finally evaluated when the last study subject has been recruited. visits \& procedures patients participating in the trial will attend a total of one visit (1 year follow up visit). subjects will be selected from the physician's usual subjects' practice. all subjects meeting the inclusion criteria and having signed the informed consent form will be evaluated by the investigator according to the study protocol. 1 year follow up visit: pre-operation visit: performed to check inclusion criteria, and to sign the informed consent.

Eligibility criteria:
inclusion criteria: * implanted bilaterally using hanita intensity sl iol * 12 to 24 months post implantation * signed informed consent exclusion criteria: • patients with any other pre-implantation and post implantation eye disease or condition that might affect the safety and efficacy evaluation.

Keywords: cataract iol hanita lenses
effect of opioid-free anesthesia on postoperative nausea and vomiting in patients undergoing video-assisted thoracoscopic surgery

Conditions: Postoperative Nausea and Vomiting; Opioid Use; Thoracic Diseases

Summary: this study aimed to verify whether an opioid-free anesthesia (ofa) could effectively reduce the incidence of ponv after thoracoscopic-assisted surgery compared with standard general anesthesia (oa) regimens.

postoperative nausea and vomiting (ponv) is one of the most common complications after general anesthesia, which significantly reduces postoperative comfort and satisfaction of patients perioperatively. meta-analysis showed that opioid-free anesthesia (ofa) significantly reduced the risk of postoperative ponv events in patients undergoing gynecology, breast, and abdominal surgery compared with standard general anesthesia (oa). the main hypothesis of the study is that an ofa could reduce the incidence of ponv in patients after thoracoscopic-assisted surgery than oa.

Eligibility criteria:
inclusion criteria: * inpatients planning elective thoracoscopic lobectomy or wedge resection under general anesthesia exclusion criteria: * asa classification \> 4 * bmi\>35kg/m2 * unable to communicate before surgery * received radiation therapy, chemotherapy, opioids or hormonal drugs within 14 days before surgery * anticipated intolerance to the anesthesia protocol of this study * expect prolonged mechanical ventilation after surgery * decline
paper vs. internet

Conditions: Idiopathic Scoliosis; Adolescent

Summary: research has shown that questionnaires completed on the internet have the potential to provide more complete and honest data with fewer errors in a more efficient manner than questionnaires completed using the paper and pencil format. despite the numerous advantages of internet-administered questionnaires, it is important to make sure that the internet questionnaires will yield comparable results to the well-established paper and pencil versions. no one has studied internet administration of scoliosis specific questionnaires in adolescents with scoliosis. the investigators will test whether the internet administration of scoliosis questionnaires is as reliable as the traditional paper and pencil version. the investigators predict that the internet-administered questionnaire will provide the same reliability as the paper-administered questionnaires.


Eligibility criteria:
inclusion criteria: * aged 10-18 * male or female * diagnosis of adolescent or juvenile idiopathic scoliosis * home access to computer and internet * capable or oral and written communication in english exclusion criteria: * unable to communicate in english

Keywords: scoliosis adolescents questionnaire reliability
the effect of tele-nursing based motivational interviewing in individuals with type 2 diabetes:rct

Conditions: Type2 Diabetes; Self Efficacy; Self Management; Tele-nursing; Motivational Interview; LDL - Low Density Lipoprotein Receptor Disorder; High Density Lipoprotein Deficiency; Cholesterol; Lipidosis

Summary: this study carried out to examine the effect of tele-nursing based motivational interviewing on diabetes self-efficacy, diabetes self-management and metabolic control parameters (body mass index, waist circumference, hba1c%,fasting blood glucose, ldl cholesterol, hdl cholesterol, total cholesterol, triglyceride) in individuals with type 2 diabetes.

the first researcher of the article who applied motivational interviewing techniques has a "motivational interviewing techniques training" certificate. a motivational interview (mi) program based on the telenursing approach was prepared by the researchers based on the literature for the individuals in the experimental group. in this study, the mi procedure includes eight sessions in total, with four sessions of motivational interviews by phone in the first month of the intervention and four sessions of motivational interviews by phone in the next two months for each individual. pre-tests were collected in the first month. afterwards, mi intervention was applied for three months. this intervention was applied to the experimental group in addition to the routine care provided by the hospital. mi application took an average of 45-60 minutes via phone call.

Eligibility criteria:
inclusion criteria: 1) being over 18 years old, 2) receiving insulin or insulin + oral therapy, 3) diagnosis of type 2 diabetes at least one year ago, 4) having a bmi of 25 and above, 5) hba1c value of 7 and above, 6) access to phone, 7) voluntarily agreeing to participate in the study. exclusion criteria: 1) have a physical disability.
comparative effects of laser and extracorpeal shock wave in patients with achilles tendinopathy.

Conditions: Achilles Tendinopathy

Summary: achilles tendinopathy is a prevalent condition characterized by pain, swelling, and impaired function of the achilles tendon, commonly affecting athletes and active individuals. the disorder arises from a failed healing response, leading to degenerative changes in the tendon without significant inflammation. it is categorized into insertional (at the calcaneus-achilles junction) and non-insertional (2-6 cm proximal to the insertion) types. intrinsic risk factors include biomechanical abnormalities and systemic conditions like diabetes and hypertension, while extrinsic factors involve excessive mechanical load and training errors. effective management of achilles tendinopathy is crucial for preventing long-term disability and ensuring the continuation of physical activities.

this study is a randomized clinical trial aimed at comparing the effectiveness of laser therapy and extracorporeal shock wave therapy on pain, range of motion, and function in patients with achilles tendinopathy. the trial will be conducted at hameed latif hospital, lahore, punjab, over a duration of nine months. a total of 44 participants, aged 18-40, diagnosed with achilles tendinopathy and meeting specific inclusion criteria, will be randomly allocated into two groups using a lottery method. group a will receive laser therapy, and group b will undergo extracorporeal shock wave. baseline and post-treatment measurements will be taken using the visual analogue scale , foot and ankle outcome score , and goniometric measurements for range of motion. the data will be analyzed using spss software to evaluate the effectiveness of each treatment modality. for group a, laser therapy will be administered using the laser therapy unit, a class 3b laser with an 810-nm, 100-milliwatt infrared probe. the treatment will be applied to six standardized points around the achilles tendon for 30 seconds each, providing a total dose of 18 joule per session. group b will receive extracorporeal shock wave with each session involving 1500-3000 pulses at a frequency of 1-4 hertz. treatments will be conducted once a week for three weeks, with a one-week break between sessions. both therapies aim to reduce pain and improve function by enhancing the healing processes of the damaged tendon.

Eligibility criteria:
inclusion criteria: * age of patients 18-40. * diagnosed with chronic achillis tendinopathy and nprs rating more than 2. * both male and female. * patient must be diagnosed with achillis tendinopathy by single leg raise or thompson test. exclusion criteria: * contraindications to lllt to the area of the achilles tendon. * comorbid musculoskeletal or serious conditions that may have confounded treatment or anticipated recovery . * nonsteroidal anti-inflammatory drug use steroid injections or surgery for the condition; insertional tendinopathy or bursitis (retrocalcaneal or achilles; determined by clinical examination. * neurologic signs; and adverse neural tension affecting the sciatic or sural nerve.

Keywords: pain function range of motion
the reinforcing mechanisms of smoking in adult adhd

Conditions: ADHD

Summary: whereas the smoking prevalence rates in the general population are declining, rates among people diagnosed with attention-deficit hyperactivity disorder (adhd) continue to be elevated. smoking may be a form of self-medication in people with adhd, which has specific reinforcing mechanisms such as improvement of adhd core symptoms, enhancement of moods and arousal, or a combination of both. in addition, the reinforcing effects of smoking may be potentiated by stimulant medication. the study examined the reinforcing effects of ad libitum smoking with and without adhd medication in adult smokers with clinically diagnosed adhd. participants were adults with adhd. the effects of two day of adhd medication compared to two days on placebo for were studied on nicotine intake (i.e., cotinine levels). in addition, task performance on the continuous performance task and nicotine withdrawal symptoms were examined in response to adhd medication + smoking a cigarette versus adhd medication + abstinence versus placebo medication + smoking versus placebo medication + abstinence. the study identified the reinforcing mechanisms of smoking in interaction with adhd medication. the findings will contribute to a better understanding of nicotine addiction and facilitate the development of targeted smoking cessation and prevention programs for individuals with adhd and other people with deficiencies in impulse control and excessive risk taking.


Eligibility criteria:
inclusion criteria: * an age of 18 to 45 years * a history of adhd * current diagnosis of adhd according to clinical criteria * current treatment with stimulant medication * smoking of 10 cigarettes or more per day exclusion criteria: * treatment for any major medical illness such as cancer, heart disease, diabetes, skin diseases, current major depressive episode, and schizophrenia even if currently controlled by medication * current pregnancy, as measured by a pregnancy test (clear blue easy, unipath, bedford, uk), or planning to become pregnant within the next 6 months. these individuals will not be included because smoking may cause harm to the unborn fetus * nursing mothers * non-english speaking people, because the majority of measurements used in the study have not been validated in languages other than english

Keywords: smoking adhd stimulant medication
hypnotic intake and motor and cognitive performances at high altitude

Conditions: Physiology

Summary: this study aims to determine the effect of acute hypnotic intake (zolpidem) on sleep, cognitive and motor performances and on acute mountain sickness symptoms at high altitude. healthy subjects will be evaluated on 4 occasions (twice at sea level and twice at high altitude), after hypnotic or placebo intake. following an early wake-up (01:00), symptoms, cognitive and motor performances will be assessed to determine potential residual effects of zolpidem within such conditions.


Eligibility criteria:
inclusion criteria: * no sojourn above 2500 m during the past 2 months * coffee intake \< 3 cups per day * non-smoker exclusion criteria: * respiratory, cardiovascular, metabolic or neuromuscular diseases * psychiatric disorders * use of hypnotics within the past year * dependence syndrome (alcool, drugs, etc) * severe insomnia or somnolence
anti-e1e2 (d32.10 epitope-binding) antibodies status prior therapy favors direct-acting antiviral treatment efficacy

Conditions: Chronic Hepatitis c

Summary: the hypothesis was to check whether baseline anti-e1e2 antibodies could predict virological outcome in hepatitis c virus (hcv)-infected patients receiving direct-acting antiviral treatment

presence of anti-e1e2 antibodies was previously associated with spontaneous cure of hepatitis c virus (hcv). the hypothesis was to check whether baseline anti-e1e2 antibodies could predict virological outcome in hcv-infected patients receiving direct-acting antiviral treatment

Eligibility criteria:
inclusion criteria: * 18 years of age or older * hcv patients treated with direct-acting antiviral treatment * patients with a prior treatment blood sample * patients with sustained virological response or virological relapse exclusion criteria: * hiv or hepatitis b virus (hbv) coinfection
addition of naltrexone to methadone taper

Conditions: Heroin Dependence; Opioid-Related Disorders; Substance-Related Disorders

Summary: there is a continuing search for more effective opiate detoxification treatments. this study's purpose is to investigate the effects of adding very low doses of naltrexone to a methadone tapering treatment in opioid dependent individuals.

although many different techniques for opiate detoxification exist, the search continues for more effective approaches to reduce the duration and discomfort associated with opioid withdrawal. it has been shown that very low doses of naltrexone administered in the presence of opiates has analgesic and dependency reducing properties. the purpose of this study is to investigate the effects of very low doses of naltrexone administered during a methadone tapering schedule for opiate detoxification. in addition, this study will compare the effectiveness of two different dose regimens of naltrexone. participants in this double-blind study will be recruited among opioid dependent individuals already enrolled in a 6-day inpatient opioid detoxification program. participants will be already receiving standard treatment to control discomfort during a methadone tapering schedule. participants will be randomly assigned to one of three groups. two of the groups will be given naltrexone; group 1 will receive 0.125 mg each day, and group 2 will receive 0.250 mg each day. group 3 will receive a placebo. participants will be evaluated upon enrollment for opiate addiction severity. they will continue to be evaluated daily for signs of withdrawal and salivary cortisol. an additional evaluation and urine test will be completed 1 day following discharge. daily evaluations will take 15 minutes to complete. seven days following discharge, participants will be contacted for a 20-minute phone interview. during the phone interview, participants will schedule an appointment to provide a final urine specimen for the detection of drugs of abuse.

Eligibility criteria:
inclusion criteria: * current dsm-iv diagnosis of opiate dependence * reads and understands english exclusion criteria: * serious medical disorders (e.g., uncontrolled hypertension, acute or chronic active hepatitis, kidney failure, uncontrolled diabetes) * psychiatric conditions that require intensive services (e.g., depression with suicidal ideation, psychosis) * mental retardation or other disorder that might limit ability to give informed consent * pregnant

Keywords: opiate dependence
effectiveness of a neuromuscular exercise program and visual feedback in the management of body position for stroke survivors

Conditions: Brain Ischemia; Stroke, Ischemic

Summary: the aim of the biomedical research is to evaluate the changes of body position management during standing and walking for stroke patients, using innovative training methods during the rehabilitation.


Eligibility criteria:
inclusion criteria: * experienced an ischemic stroke for the first time; * middle-aged (44-59) and elderly (60-74) by who classification; * muscle strength of the lower extremities according to the oxford scale is 3-5 points; * do not have any neglect; * mini mental state examination \>12 points. exclusion criteria: * experienced an ischemic stroke not for the first time; * had hip or knee replacement surgery's, which may affect gait; * muscle strength of the lower extremities according to the oxford scale is 0-2 points; * have neglect; * mini mental state examination \<12 points.

Keywords: brain ischemia stroke balance gait physiotherapy physical therapy visual feedback
effects of creatine supplementation in breast cancer survivors

Conditions: Breast Cancer; Chemotherapy Effect; Muscle Weakness; Muscle Loss; Exercise

Summary: the purpose of this study is to test the hypothesis that creatine will accelerate adaptations associated with exercise in breast cancer survivors recently completing chemotherapy.

the primary objective of this study is to determine the effects of creatine supplementation in modulating strength and physical function in breast cancer survivors that have recently completed chemotherapy. the primary hypothesis for this objective is that creatine will lead to significantly greater gains in strength and physical function in breast cancer survivors compared to exercise alone. the secondary objective is to determine if supplemental creatine can increase intramuscular storage of creatine and alter energy storage. the hypothesis for this objective is that creatine supplementation will significantly increase intramuscular concentrations of creatine (cr), phosphocreatine (pcr) and adenosine triphosphate (atp) in the vastus lateralis (vl) compared to controls. the secondary hypothesis for this objective is that the creatine group will have significantly greater muscle cross-sectional area and significantly lower intramuscular fat compared to controls. the final objective for this study is to test the hypothesis that creatine supplementation will improve body composition in breast cancer survivors.

Eligibility criteria:
inclusion criteria: * age 18-75 years of age * recent (within 6 months) completion of chemotherapy * willing to attend 3 virtual exercise sessions per week * able to take oral medications * participant is willing and able to provide consent to participating in the study * serum creatinine ≤ 1.5 x uln or estimated glomerular filtration rate (egfr) ≥30 ml/min/1.73 m2 by chronic kidney disease epidemiology collaboration equation. exclusion criteria: * physical indications where performing exercise may be limited and/or contraindicated * poorly-controlled hypertension (blood pressure \> 160/95mmhg) * current tobacco use (within 6 months) * anabolic steroids use * pitting edema * currently undergoing chemotherapy * history of moderate-severe heart disease (new york heart classification greater than grade ii) or pulmonary disease (dyspnea on exertion upon climbing one flight of stairs or less; abnormal breath sounds on auscultation). * pregnant or plan to get pregnant during the study * recent (within one month) or anticipated treatment with corticosteroids (except for short term use during the time of chemotherapy), androgens, progestational agents, or other appetite stimulants * serum creatinine \> 1.5 x uln or estimated glomerular filtration rate (egfr) \< 30 ml/min/1.73 m2 by chronic kidney disease epidemiology collaboration equation. * currently taking creatine supplements

Keywords: special populations exercise oncology creatine supplementation magnetic resonance spectroscopy