Kornimate/medical-research-clean huggingface dataset:
near infrared spectroscopy (nirs) in severe sepsis

Conditions: Critical Illness; Severe Sepsis

Summary: the purpose of this study is to evaluate the usefulness of an optimization of muscle perfusion and oxygenation, as assessed by the nirs technique, in critically ill patients with sepsis.

the systemic inflammatory response to sepsis may cause impaired tissue oxygenation that can persist despite the restoration of a normal hemodynamic profile and systemic oxygen transport. therefore, the assessment of tissue oxygenation and perfusion is recommended in patients with severe sepsis. the inspectra tissue spectrometer relies on continuous wave near infrared (nir) technology to estimate non invasively local tissue hemoglobin oxygen saturation in tissue (% sto2). this technology had been tested in a variety of systems: standard theoretical models of light transport, isolated blood, isolated blood-perfused animal organs and healthy human volunteers with induced limb ischemia. in critical-care medicine, nirs has also been used to evaluate muscle oxygenation in trauma resuscitation and in lower extremity and abdominal compartment syndrome. however, nirs has been rarely utilised to measure tissue blood flow and oxygen uptake in critically ill patients.

Eligibility criteria:
inclusion criteria: * two of four criteria for the systemic inflammatory response syndrome; and one of the following: * systolic blood pressure =\< 90 mm hg; or * a blood lactate concentration =\> 4 mmol/l; or * skin marbling; or * impaired consciousness; or * urine output \< 30 ml/h. exclusion criteria: * age \< 18 years * pregnancy * do-not-resuscitate status * advanced directives restricting implementation of the protocol * obesity (body mass index \[bmi\] \> 30) * anasarca

Keywords: near infrared spectroscopy tissue oxygenation organ dysfunction mortality
screening for excessive gambling behaviors on the internet

Conditions: Gambling, Pathological

Summary: the internet medium is particularly vector for gambling problems. since the opening of the online gambling sector in france, no screening for excessive gambling behaviours is provided for by the law, although it is known that preventive actions are more effective if they are implemented early in the gambler's career. the investigators propose to develop a model for screening excessive gambling practices based on the gambling behaviours observed on french gambling websites, coupled to a clinical validation. the objective is to lead to early preventive measures directed towards the more vulnerable gamblers and adapted for each type of gambling. this study will therefore contribute to setting up an innovative measure of prevention, to inform and protect gamblers as early as possible.


Eligibility criteria:
inclusion criteria: * users of french online gambling websites * users with active accounts * users that have placed at least one bet during the last 12 months exclusion criteria: * minor

Keywords: gambling disorder screening model online gambling clinical validation
an extension study of krn23 in adults with x-linked hypophosphatemia

Conditions: X-linked Hypophosphatemia

Summary: the primary purpose of this study is to assess the safety and efficacy of repeated subcutaneous (sc) injections of krn23 in adult subjects with x-linked hypophosphatemia (xlh).


Eligibility criteria:
inclusion criteria: 1. satisfactory completion of kkp's sponsored krn23-int-001 clinical trial 2. egfr ≥ 60 ml/min 3. corrected ca \< 10.8 mg/dl 4. for female of child-bearing potential, a negative serum pregnancy test 5. a willingness to utilize adequate contraception and not become pregnant \[or to have their partner(s) become pregnant\] during the study 6. additional inclusion criteria apply exclusion criteria: 1. subject experienced a safety-related event in the krn23-int-001 study 2. pregnant or lactating female subject or pregnant or female planning to become pregnant during the study 3. receipt of a live (attenuated) vaccine (except for influenza vaccines) during the course of the krn23-int-001 study and/or of this study 4. condition which could present a concern for either the subject's safety or difficulty with data interpretation 5. additional exclusion criteria apply

Keywords: xlh
assessment of the potential interactions between cocaine and gbr 12909 - 1

Conditions: Cocaine-Related Disorders

Summary: the purpose of this study is to assess the potential interactions between iv cocaine and gbr 12909.

this is a single dose with escalation, double-blind, placebo-controlled inpatient study in which 24 cocaine experienced volunteers that meet protocol eligibility criteria during a 30 day screen period will be randomized into three dose groups.

Eligibility criteria:
inclusion criteria: * must understand study procedures and provide written informed consent * for additional inclusion criteria information, please contact study site for more information. exclusion criteria: * please contact study site for more information.
do taping and orthosis affect pain, gait, or functionality in mild knee osteoarthritis?

Conditions: Osteoarthritis, Knee

Summary: objective: the aim of this study was to compare the effects of elastic taping, rigid taping, and braces applied to women with mild knee osteoartritis(oa) on pain, gait, and knee functionality. methods: this randomised study included 21 female patients (mean age of 53.81±6.20 years) with bilateral grade 2 knee oa according to the kellgren \& lawrence classification. pain was evaluated with the visual analog scale, functionality was evaluated with the western ontario mcmaster osteoarthritis index, and the kinetic, kinematic, and spatiotemporal parameters were evaluated using a three-dimensional gait analysis system at baseline (no application) and immediately after the application of elastic taping, rigid taping, and orthoses. the dependent variables were measured after 45 minute the application of four different conditions neutral, elastic taping, rigid taping, and knee brace on each participant with 1-day intervals.

objective: the aim of this study was to compare the effects of elastic taping, rigid taping, and braces applied to women with mild knee oa on pain, gait, and knee functionality. methods: this randomised study included 21 female patients (mean age of 53.81±6.20 years) with bilateral grade 2 knee oa according to the kellgren \& lawrence classification. pain was evaluated with the visual analog scale, functionality was evaluated with the western ontario mcmaster osteoarthritis index, and the kinetic, kinematic, and spatiotemporal parameters were evaluated using a three-dimensional gait analysis system at baseline (no application) and immediately after the application of elastic taping, rigid taping, and orthoses. the dependent variables were measured after 45 minute the application of four different conditions neutral, elastic taping, rigid taping, and knee brace on each participant with 1-day intervals.

Eligibility criteria:
inclusion criteria: * bilateral knee oa according to the criteria of the american college of rheumatology * had radiographically phase 2 based on the criteria identified by kellgren \& lawrence -, had active knee pain * did not receive any knee treatment in the last year * could understand test and evaluations exclusion criteria: * experienced lower extremity trauma or underwent surgery * had phase 3-4 osteoarthritis * had any orthopedic or neurologic problem affecting walking * were allergic to taping * did not walk independently on their own

Keywords: knee osteoarthritis athletic tape brace kinesiotape gait
uv exposure assessed with wearable sensor and sun protection

Conditions: Sunburn, Erythema; Sun Protection

Summary: the goal is to prevent ultraviolet light (uv) overexposure by providing consumers with relevant, easy-to-access, specifically actionable information. this research proposal will develop a uv protection system consisting of an automated real-time counseling framework and a personal dosimeter that overcomes barriers to consumer adoption. these new, wearable sensors take the form of small (\< 1 cm), thin (\<0.1 mm), lightweight (\<0.1 g), battery-free "stickers" that are fundamentally differentiated from other wearable electronics in their modes of use, cost structures and accuracy.

the proposed work is to refine and validate a uv protection system based on a dosimeter "sticker." the key innovations of the system are automated personalized intervention messaging triggered by the exposure levels measured by a novel charge accumulation device applied to ultraminiaturized circuit forms. the research will validate the system's accuracy and acceptability to users, refine the device, and prove its robustness and efficacy in real world use cases. focus groups and structured interviews will develop sun protection strategies to be communicated by text messages to participants. successful completion of the research will yield a system to prevent excessive uv exposure and sunburn, thus reducing the incidence of skin cancer by equipping large numbers of general-population consumers and at-risk people to practice digitally-informed healthy sun behavior.

Eligibility criteria:
cohort study 1: inclusion criteria: 1. history of stage 0 to iib melanoma treated within the last five years, age 18-70 years old 2. have a smartphone 3. familiarity with use of mobile apps 4. have skin type 1-3 5. willing to wear the sensor and able to transmit data which requires wi-fi in the home 6. come to the chicago campus of the medical school exclusion criteria: - cohort study 2: young adults with sun sensitive skin inclusion criteria: 1. history of sun sensitive skin, skin type 1-3 2. have a smartphone and willing to use the uv guard application on the smartphone 3. reliable wireless internet connection to complete daily surveys 4. willing to wear the sensor for 28 days and transmit data and complete daily surveys 5. willing to receive sms text messages on their personal phone and potentially sync sensor to personal phone using bluetooth 6. if weather permits, person will spend at least one hour outdoors each day, with at least 30 minutes of that hour being consecutive between the hours of 8 am and 5 pm exclusion criteria: 1. unable to speak english 2. lacking a secure internet connection or very little experience with smartphones and mobile applications . 3. unable to walk inside and outside independently 4. unable to be outdoors for at least one hour each day (weather permitting) 5. unable to be outdoors for 30 consecutive minutes a day between 8 am and 5 pm.

Keywords: skin cancer sunburn, erythema uv exposure, sunburn wearable uv device
the serum metabolite based precogcolo dx test for advanced colorectal neoplasia screening

Conditions: Colorectal Adenoma

Summary: this study is to evaluate the diagnostic sensitivity of the serum metabolite based precogcolo dx test for advanced colorectal neoplasia screening, including advanced adenoma and colorectal cancer. there are two steps in this study. firstly, the diagnostic model is established based on tumor-specific and gut-microbiome related serum metabolites. secondly, the sensitivity, specificity and accuracy of the diagnostic model is evaluated in detecting advanced adenoma and colorectal cancer stages in an independent multi-centered cohort.

subjects aged \>45 at average risk for development of crc will be enrolled. subjects will complete the precogcolo dx test, followed by completion of a screening colonoscopy. . results from precogcolo dx test were compared to the results of an optical colonoscopic examination, and histopathological diagnosis of all significant lesions discovered during the colonoscopy, in order to determine the sensitivity for crc and advanced adenoma, respectively, as well as determining specificity of non-advanced neoplasia individuals. histopathological results from biopsied tissue or excised lesions were categorized based on the most clinically significant lesion present by a central pathologist.

Eligibility criteria:
inclusion criteria: 1. subject is ≥ 45 years of age at the time of enrollment. 2. subject presents for a screening colonoscopy. 3. subject has no symptoms or signs that require immediate, or near term, referral for diagnostic or therapeutic colonoscopy. 4. subject is able and willing to sign informed consent. exclusion criteria: 1. patients received tumor treatment prior to the drawn of blood sample, including surgical resection, neoadjuvant chemotherapy, neoadjuvant chemoradiotherapy and targeted therapy. 2. patients received antibiotics within 2 weeks. 3. patients with indications of emergency surgery, including bleeding, obstruction and perforation. 4. patients who are positive for human immunodeficiency virus (hiv). 5. patients with abnormal liver and kidney function. 6. patients with the history of inflammatory bowel disease. 7. patients who had history of other malignancies. 8. subject has a diagnosis or medical history of any of the following conditions: 1. familial adenomatous polyposis (also referred to as "fap", including attenuated fap and gardner's syndrome) 2. hereditary non-polyposis crc syndrome (also referred to as "hnpcc" or "lynch syndrome")

Keywords: colorectal adenomas; colorectal cancer
study of [18f]fapi-74 pet in patients with gastrointestinal cancers

Conditions: Gastrointestinal Cancers; Cholangiocarcinoma; Gastric Cancer; Colorectal Cancer; Pancreatic Ductal Adenocarcinoma; Hepatocellular Carcinoma

Summary: prospective, multi-center, open label, non-randomized clinical trial to assess efficacy of \[18f\]fapi-74 to detect fap expressing cells in patients diagnosed with gastrointestinal cancers, including hepatocellular carcinoma, cholangiocarcinoma, gastric, pancreatic and colorectal cancer. the \[18f\]fapi-74 pet scan will be acquired in patients with proven gi cancers after initial staging using institutional standard methods. the pet scan results will be compared to fap immunohistochemistry (as the primary objective) and histopathology (as the secondary objective) of the biopsied or resected tissues.


Eligibility criteria:
inclusion criteria: * confirmed diagnosis of gastrointestinal (gi) malignancy, including hepatocellular carcinoma, cholangiocarcinoma, gastric, pancreatic and colorectal cancer * available tissue sample obtained through biopsy or to be obtained through scheduled biopsy and/or surgical resection * no treatment received between tissue sample taken and \[18f\]fapi-74 pet * anatomic imaging (e.g., ct, mri) obtained within ≤ 28 days of consent * age ≥ 18 years * completed informed consent as determined per the irb of record exclusion criteria: * pregnant as determined by a pregnancy test as per institutional guidelines for individuals of child-bearing potential * declining to use effective contraceptive methods during the study (for individuals of child-producing potential) * need for emergent surgery that would be delayed by participation * bacterial, viral, or fungal infections requiring systemic therapy, that are expected to impact fap expression in the opinion of the sponsor or their designee * serious co-morbidities and serious nonmalignant disease (e.g., hydronephrosis, kidney failure, liver failure, systemic or local inflammatory or autoimmune diseases or other conditions) that in the opinion of the investigator, physician of record and/or sofie could compromise subject safety and/or protocol objectives * known diagnosis of an autoimmune disorder that is expected to impact fap expression in the opinion of the sponsor or their designee * patients receiving any other investigational agent within the past 28 days * breastfeeding. note: nursing parents are allowed if the potential participant commits to pumping breast milk and discarding it from injection to ≥ 24 hours from the time of the \[18f\]fapi-74 injection * known hypersensitivity to any excipients used in \[18f\]fapi-74: trace amounts of sodium acetate, sodium ascorbate, ascorbic acid, ethanol, acetonitrile or alcl. * renal or liver function impairment\* \*defined by liver impairments as ast\>3x the upper limit of normal, alt\>3x the upper limit of normal, or bilirubin\>1.5x the upper limit of normal. renal impairment as defined by a creatinine clearance of \>1.5x the upper limit of normal utilizing the cockcroft gault formula

Keywords: fibroblast activation protein fibroblast activation protein inhibitor fapi gastrointestinal cancer
rtms to enhance cognitive performance and promote resilience

Conditions: Cognition; Stress Reaction

Summary: the purpose of this study is to determine the most effective dose of brief, non-invasive brain stimulation (repetitive transcranial magnetic stimulation, rtms) for improving cognitive functions such as attention and memory as well as to improve the ability to recover from stressful situations (stress resilience).

repetitive transcranial magnetic stimulation (rtms) works by rapidly turning a focused magnetic field on-and-off repeatedly over your head, which passes directly through your hair, scalp, and skull and onto your brain, and can temporarily increase brain activity under the magnetic field. repetitive transcranial magnetic stimulation (rtms) is an fda approved treatment for depression, and is used commonly to treat people for their depression. the rtms treatment regime used in this study is different from the fda approved treatment because you will receive up to ten treatments per day over five days instead of the fda approved rtms treatment regime of 25 treatments over 25 days. this sort of accelerated or high dose protocol has been shown to be safe and effective in the treatment of depression. we are hoping to find out if this treatment can be used as a treatment for improving cognitive function and stress resilience.

Eligibility criteria:
inclusion criteria: 1. no history of mental or physical illness 2. no implanted metal in the body 3. college graduates (associates degree or higher) 4. negative urine pregnancy test, if female subject of childbearing potential 5. able to read and understand questionnaires and informed consent exclusion criteria: 1. any current psychiatric diagnosis or current clinical global impression ratings of psychiatric illness \> 1 2. current physical illness 3. history of cns disease, concussion, overnight hospitalization, tumors, seizures, meningitis, encephalitis, abnormal ct/mri of the brain 4. moderate to severe traumatic brain injury (tbi) 5. history of a continuing significant laboratory finding 6. frequent or severe headaches 7. any history of psychotropic medication prior to study enrollment 8. females of childbearing potential who are pregnant (by urine hcg), nursing, or who are not using a reliable form of birth control. 9. active participation or plan for enrollment in another evidence-based clinical trial affecting psychosocial function 10. repeated abuse or dependence upon drugs (excluding nicotine and caffeine) 11. implanted devices/ferrous metal of any kind

Keywords: cognition adult prefrontal cortex transcranial magnetic stimulation stress, psychological memory attention
fast track surgery with laparoscopic-assisted gastrectomy for advanced gastric cancer: a randomized controlled trial

Conditions: Gastric Cancer

Summary: the purpose of this study is to to investigate the feasibility and safety of fast-track surgery when combined with laparoscopic-assisted gastrectomy for advanced gastric cancer patients.

methods: we designed a prospective randomized, controlled clinical trial then recruited 61 consecutive advanced gastric cancer patients. (trial registration number: jlufhc1722013) further divide into a fast-track surgery group (n=30) and a conventional surgery group (n=31). surgical technique in both groups is same laparoscopic-assisted gastrectomy with d2 lymphadenectomy. compare outcomes includes length of hospital stay, return to normal diet and postoperative complications.results: recovery parameters such as the length of time to return to normal diet; to the first defection; start of ambulation time ;the mean hospital stay will be all less in patients assigned to the fast track surgery protocol compared with those in the conventional care programme. conclusion: we will consider fast-track rehabilitation to be safe and feasible in advanced gastric cancer patients. moreover, it will result in decreased hospital stay.

Eligibility criteria:
inclusion criteria: * diagnosis of advanced gastric cancer, elective laparoscopic surgery and age under 75. exclusion criteria: * patients with early gastric cancer, received neoadjuvant chemotherapy, had pyloric obstruction or with distant metastasis were excluded from the study.

Keywords: fast-track surgery, laparoscopic gastrectomy
a clinical model for dialysis discontinuation in aki

Conditions: Acute Renal Failure; Acute Kidney Injury

Summary: a retrospective study evaluating aki patients in whom rrt was interrupted for at least 48 hours. patients who were still rrt-independent 7 days after initial rrt cessation were included in the "success" group, as opposed to the "failure" group. baseline characteristics and variables at the time of rrt interruption were collected. multivariable analysis was performed and a model was generated to evaluate the prediction of success.


Eligibility criteria:
inclusion criteria: * all patients receiving kidney replacement therapy due to aki from october 2020 to february 2022 were considered for inclusion in the study. patients who managed to remain at least 48 consecutive hours without receiving kidney replacement therapy prescription were included. exclusion criteria: * patients who had kidney replacement therapy interrupted exclusively due to haemodynamic instability, death or decision for palliative care were excluded.
a study of omega-3 as a treatment for major depression

Conditions: Major Depression; Dysthymia

Summary: the purpose of this study is to determine whether omega-3 polyunsaturated fatty acids are effective as a monotherapy for depression.

the study will be a 6 week, parallel-group, double-blind randomized controlled trial of the efficacy of omega-3 as a monotherapy for depression. people aged 21-65 who have major depression but are not currently on an antidepressant or planning to take an antidepressant in the next 14 weeks will be recruited. participants will be randomly allocated to receive omega-3 (fish oil) or placebo (paraffin oil) for 6 weeks. participants will be followed up weekly and will be asked to rate their mood daily for the 6 week study period. blood samples will be taken pre and post treatment to measure change in omega-3 levels. at the end of 6 weeks all participants will receive a further 8 weeks supply of omega-3.

Eligibility criteria:
inclusion criteria: * must meet dsm iv criteria for non-psychotic major depression lasting at least 6 weeks or dysthymia. * must be under the care of a mental health practitioner. * must be able to give informed consent. * must be able to attend the black dog institute. exclusion criteria: * unsuccessful treatment with more than 2 antidepressant medications (at therapeutically adequate doses and duration. * history of psychosis or mania/hypomania or personality disorder. * non-english speaking or otherwise unable to provide historical information. * having taken omega-3 dietary supplements in the last 3 months. * taking antidepressant medication for depression. * history of allergy to n-3 pufa supplements, finfish or shellfish. * pregnancy, breast feeding or planning to become pregnant during course of study. * post-natal depression. * current drug or alcohol abuse or dependence or history of abuse or dependence over the last 12 months. * unstable thyroid function * hepatic or renal impairment or other medical conditions that may interfere with the absorption and metabolism of omega-3 polyunsaturated fatty acids. * coagulopathy or anticoagulant treatment. * patients who, in the investigator's judgment pose a current serious suicidal or other safety risk, or patients who are not likely to be able to comply with the study protocol.

Keywords: mood disorder