Kornimate/medical-research-clean huggingface dataset:
a clinical study using medi-551 in adult participants with relapsed or refractory advanced b-cell malignancies

Conditions: B-cell Malignancies; Cancer

Summary: the purpose of this study is to determine the maximum tolerated dose of this drug (medi-551) in participants with advanced b-cell malignancies. expansion to occur at maximum tolerated dose (mtd), or if not reached, at optimal biologic dose (obd).

to determine the mtd or obd of medi-551 in participants with relapsed or refractory advanced b-cell malignancies.

Eligibility criteria:
inclusion criteria: * histologically confirmed cll, dlbcl, fl, or mm; * karnofsky performance status \>= 70; * life expectancy of \>= 12 weeks; * prior radiation therapy provided exposure does not exceed an area of 25% of marrow space * adequate hematological function * adequate organ function exclusion criteria: * any available standard line of therapy known to be life-prolonging or life-saving; * no concurrent therapy or therapy within six weeks of first dose of medi-551 for treatment of cancer * previous therapy directed against cd19 * vaccination (other than experimental cancer vaccine therapy) within 28 days prior to receiving the first dose of medi-551; * history of other invasive malignancy within 5 years except for cervical carcinoma in situ (cis), non-melanomatous carcinoma of the skin or ductal carcinoma in situ (dcis) of the breast that have been surgically cured; * active infection requiring treatment * autologous stem cell transplantation within 4 months prior to study entry; * allogeneic stem cell transplantation or any other organ transplant; * ongoing \>= grade 2 toxicities from previous cancer therapies unless specifically allowed in the inclusion/exclusion criteria. * use of immunosuppressive medication other than steroids within 28 days before the first dose of medi-551; * use of immunosuppressive medication other than steroids within 28 days before the first dose of medi-551 (inhaled and topical corticosteroids are permitted); * documented current central nervous system involvement by leukemia or lymphoma; * pregnancy or lactation; * clinically significant abnormality on ecg.

Keywords: cancer
regional network for acute myocardial infarction

Conditions: Coronary Heart Disease; Acute Myocardial Infarction; STEMI - ST Elevation Myocardial Infarction

Summary: incidence of st-segment elevation myocardial infarction (stemi) is rising and the existing emergency medical aid system for stemi was not enough for timely perfusion treatment. no existing research with high-quality data focuses on the characteristic of stemi incidence and regional network construction. aiming of guangdong gami(regional network for acute myocardial infarction) project is to establish effective collaborative regional network system for stemi patients treatment.

the project of guangdong gami(regional network for acute myocardial infarction) is being conducted during 2015-2019 in eight districts with diverse economic development across southern china (integrated care model was conducted in four regions, which mainly included community public education, non primary-pci capable centre and referral system improvement, and inhospital green-channal optimization for primary-pci capable centre. other four centers were underwent usual care of acute myocardial infacrtion public and medical health service). all the st-segment elevation myocardial infarction (stemi) patients admitted in the hospital within 30 days from the symptom onset were enrolled. the key data of the timeline of stemi onset and treatment were precisely recorded. other details of stemi treatment in hospitals such as laboratory data and medication were also collected. during the research period, actions of both optimizing the regional stemi patients transfer and treatment to shorten the medical delay, as well as educating the public to improve their awareness of early treatment of stemi were taken meanwhile. in addition, laboratory data, medication, and follow-up information were recorded in a database for further analysis regarding the stemi patient treatment.

Eligibility criteria:
inclusion criteria: all adult patients who suspected diagnosis with stemi. exclusion criteria: 1. patients refused to undergo coronary angiography; 2. patients were confirmed as non-stemi by coronary angiography or the course of stemi over 1 month; 3. patients occurred onset stemi during hospitalization in hospitals

Keywords: acute myocardial infarction stemi regional network
neurobiological basis of response to vayarin in adults with adhd: an fmri study of brain activation pre and post treatment

Conditions: ADHD

Summary: the objective of this research is to use functional magnetic resonance imaging (fmri) with a neuropsychological task to test the prefrontal mechanism of action of the medical food vayarin.

the investigators prior research suggests that effective non-stimulant treatments for adhd act through key prefrontal regions that subserve inhibitory and executive functions, although different medications may achieve these effects via distinct mechanisms. the objective of this research is to use functional magnetic resonance imaging (fmri) with a face go/no-go task to test the prefrontal mechanism of action of the medical food vayarin. participants are not treated at the icahn school of medicine, but instead will be recruited from trials of vayarin that are enrolling and treating participants at new york university and the medical research network.

Eligibility criteria:
inclusion criteria: * subjects eligible to enroll in the vayarin clinical study according to screening visit will be asked to participate in the fmri study. * must be willing and able to perform fmri scanning * must maintain compliance to their trials' protocols exclusion criteria: * pre-existing medical or psychological condition that precludes scanning (e.g., claustrophobia, morbid obesity) * implanted medical device (e.g., pacemaker) * metal in the body that cannot be removed (e.g., braces) * pregnancy * concomitant use of anti-hypertensives or any other medications affecting the blood oxygenation level-dependent (bold) signal

Keywords: medical food adhd vayarin fish oil
affect of multiple health education on medication persistence and clinical prognosis of ischemic stroke patients

Conditions: Ischemic Stroke; Medication Persistence

Summary: the study aimed to demonstrate the relationship between secondary prevention medication persistence and clinical prognosis of ischemic stroke patients at 3,6,12 months

the study is a prospective, multicenter, hospital-based study on secondary prevention for patients with ischemic cerebrovascular diseases between may 2014 and june 2015. physicians from 24 hospitals in beijing underwent a standard secondary prevention training of ischemic cerebrovascular diseases by professional training, instruction manuals, stratification management software. in order to improve the persistence of taking preventive secondary medicine, is patients from these 24 hospitals received healthy education through manuals and digital video disc about health education during hospitalization and acquired secondary preventive knowledge of ischemic cerebrovascular diseases through regular health education messages during 6 months after discharge. patients with is from other 6 hospitals were used as a control, and no such intervention was given to them. telephone follow-up was performed at 3 months, 6 months, and 1 year after the onset of cerebral infarction, during which the use of antiplatelet and statins drugs and recurrence of is were recorded. patients who took antiplatelet drugs or statins at three follow-ups were regarded as persistent antiplatelet drugs or statins taking within one year after the onset of the disease. the main prognostic indicator was the recurrence of is and persistence of antiplatelet and statins medication within 1 year, and the main purpose was to explore the impact of persistent statins and antiplatelet medication use on is recurrence.

Eligibility criteria:
inclusion criteria: 1. adult subjects (male or female ≥18 years); 2. acute ischemic stroke occured within 14 days of symptoms onset 3. patients signed informed consent 4. patients have a cell phone and have the ability to receive and view messages exclusion criteria: 1. non-cerebrovascular events or hemorrhagic stroke 2. patients have serious heart, liver, kidney dysfunction or coagulation disorders 3. patients have circumstances that may affect the follow-up such as disturbance of consciousness, severe depression or other mental disorders, aphasia 4. modified rankin scale score at discharge ≥3 5. those who are participating in other clinical trials 6. those who can not guarantee with the completion of 1 year follow-up after enrollment

Keywords: ischemic stroke medication persistence outcome
differentiating between brain hemorrhage and contrast

Conditions: Ischemic Stroke

Summary: the goal of this observational study is to use artificial intelligence to differentiate cerebral hemorrhage from contrast agent extravasation after mechanical revascularization in ischemic stroke. the main question it aims to answer is: whether artificial intelligence can help differentiate brain hemorrhage from contrast agent extravasation. patients with intracranial high-density lesions on ct scans within 24h after mechanical revascularization will be included. expected to enroll 500 patients. the type of high-density lesion is determined according to dual-energy ct images or follow-up images. patients will be divided into training group, validation and testing groups by stratified random sampling (6:2:2). after the images and the image labels are obtained, deep learning artificial intelligence will be used to learn the image characteristics and establish a diagnostic model, and the model performance and generalization ability will be evaluated.


Eligibility criteria:
inclusion criteria: (1) patients underwent non-enhanced head ct after mechanical vascularization; (2) initial post-operative non-enhanced head ct was performed within 24 h after mechanical vascularization; and (3) intracranial hyper-intensity, which was defined as an objectively higher density than the surrounding grey or white matter in the parenchyma or higher density than cerebrospinal fluid in ventricles and cisterns, could be seen on the initial non-enhanced head ct after mechanical vascularization. exclusion criteria: (1) the follow-up time of non-enhanced head ct after mechanical vascularization was less than 24 h; (2) artifacts (e.g. metal artifacts or motion artifacts) affected the hyper-intensity in ct images; and (3) patients underwent craniotomy after mechanical vascularization, which made it difficult to identify the area of hyper-intensity.

Keywords: hemorrhage contrast media extravasation artificial intelligence mechanical revascularisation
cardioprotection by sevoflurane preconditioning in noncardiac thoracic surgery

Conditions: High Sensitive Troponin T Release

Summary: it has been shown that the use of volatile anaesthetics, that are usually used to perform a general anesthesia, have cardioprotective properties. this has been shown in animal studies and in patients that underwent cardiac surgery. the aim of our study is to examine if sevoflurane, a volatile anaesthetic, has this properties in patients undergoing lung surgery.


Eligibility criteria:
inclusion criteria: * lung surgery * asa (american society of anesthesiologists) physical status 1-3 exclusion criteria: * disposition for malignant hyperthermia * medication with ß-blocking drugs * use of clonidin

Keywords: volatile anesthetic cardioprotection lung surgery non cardiac surgery
comparison of clopidogrel and ticagrelor on microvascular dysfunction in st-segment elevation myocardial infarction

Conditions: Non-ST Segment Elevation Myocardial Infarction; ST Segment Elevation Myocardial Infarction

Summary: ticagrelor is a non-thienophyridine, direct p2y12 blocker that is more potent than clopidogrel and is associated with less interindividual variability. in the plato trial, it was found to be superior to clopidogrel with respect to cardiovascular outcomes and total mortality without increasing the risk of bleedings. more potent and reversible receptor bindings are possible explanation for the superior outcomes. beside the potent effect on inhibition of antiplatelet function, ticagrelor has previously been demonstrated to increase adenosine levels by inhibiting adenosine re-uptake in tissue level and can induce adenosine triphosphate (atp) release from human red cells, which both stimulate vasodilation of in red blood cells.


Eligibility criteria:
* inclusion criteria: * males and females * between the ages of 18 and 75 years * stemi patients treated with percutaneous coronary intervention * able to provide informed consent * exclusion criteria: * history of stroke or transient ischemic attack * platelet count \< 100 000/μl * known bleeding diathesis * hematocrit \ 52% * severe liver dysfunction * renal insufficiency (creatinine clearance \< 30ml/min) * pregnant females * cardiogenic shock or symptomatic hypotension or sitting sbp \< 95 mmhg
the role of biomarkers in the early detection of acute kidney injury induced by liver transplantation

Conditions: Acute Kidney Injury

Summary: renal dysfunction is a major risk factor for poorer outcome after liver transplantation. nevertheless, mechanisms of renal dysfunction in liver transplant recipients are not clearly understood. calcineurin inhibitors are generally perceived as the most important cause; however the liver transplant procedure itself represents a major surgical / hemodynamic / inflammatory trauma that - on its own - can cause renal dysfunction. creatinine and creatinine clearance are late markers of acute kidney injury and changes in these parameters occur only after substantial injury has already occurred. even a stable creatinine does not exclude structural kidney damage. a series of new markers of tissue injury have been identified and have the potential to identify acute kidney injury better and earlier than creatinine and creatinine clearance. the aim of this study is to determine whether and how liver transplantation affects these urinary and plasma biomarkers and to study whether the changes in these biomarkers may predict later changes in standard functional parameters (creatinine and creatinine clearance). for this purpose, the urinary and plasma biomarkers, together with creatinine, will be determined serially during the different phases of the liver transplant process and daily until day 5 after transplantation.


Eligibility criteria:
inclusion criteria: * older than 18 years exclusion criteria: * younger than 18 years old * combined organ transplants * dialysis dependent prior to liver transplantation

Keywords: liver transplantation acute kidney injury
site preservation after tooth extraction

Conditions: Osteogenesis Imperfecta; Total Absence of Permanent Teeth; Tooth Socket

Summary: this study is mainly targeted affected teeth which could not be retained, and patients are willing to undergo implant repair at the later stage. after teeth extraction, geistlich bio-oss ® particles or bio-oss ® collagen are immediately implanted in the teeth extraction socket and covered with bio-gide ® collagen membrane for site preservation.through postoperative follow-up, postoperative clinical and imaging objective indicators, combined with the subjective evaluation of surgeons and patients, and compared with conventional extraction treatment method, the study is aimed to evaluate the effectiveness of different site preservation of alveolar crest preservation, in order to reduce the alveolar bone width and height loss, effectively reduce alveolar bone absorption, or even achieve bone incrementation, thus to get the ideal site preservation effect, to improve the oral implant success rate, improve implant aesthetic score and patient satisfaction, provide more clinical standard reference of the clinical application of site preservation.


Eligibility criteria:
inclusion criteria: * patients willing to performed site preservation with geistlich bio-oss ® particles + bio-gide ® collagen membrane after tooth extraction; * patients willing to performed site preservation with geistlich bio-oss ® collagen + bio-gide ® collagen membrane after tooth extraction; * patients willing to performed no site preservation after tooth extraction and only conventional healing. exclusion criteria: * patients unwilling to sign the informed consent form and the letter of authorization; * patients has a potential systematic diseases; * patients had previously been treated with radiation therapy; * patients can not re-visit on time.
evaluation of nasal non invasive ventilation in management of neonates with respiratory distress using lung ultrasound

Conditions: Preterm; Ventilator Lung; Newborn

Summary: this study aims to evaluate the effect of non-invasive ventilation (nippv) , (ncpap), and nasal high flow cannula (nhfc) as a primary mode of ventilation in preterm neonates \<37 gestational week with moderate to severe rd using lus as regard: i. primary outcomes: duration of non-invasive ventilation. ii. secondary outcomes: evaluation lus over the 1 st 7 days of life or weaning from ventilation. need for intubation and invasive ventilation. duration of respiratory support. need for surfactant. oxygen saturation index and oxygen index. broncho-pulmonary dysplasia; grade. duration of hospital stay


Eligibility criteria:
inclusion criteria: preterm \<37 wk. gestational age admitted to the nicu with spontaneous breathing and clinical manifestations of rd (tachypnea, nasal flaring, intercostal and subcostal retraction and or grunting). exclusion criteria: 1. obvious major congenital abnormalities. 2. any of the baby intubated for resuscitation or for other reasons. 3. neonates need invasive mechanical ventilation. 4. pulmonary hemorrhage. 5. severe cardiovascular instability. 6. cardiopulmonary arrest needing prolonged resuscitation. 7. birth asphyxia (one-minute apgar score ≤ 3). 8. major cardiac diseases (not including patent ductus arteriosus).

Keywords: preterm infants non-invasive ventilation
whole-slide image and ct radiomics based deep learning system for prognostication prediction in bladder cancer

Conditions: Bladder Cancer

Summary: bladder cancer (blca), with its diverse histopathological features and varying patient outcomes, poses significant challenges in diagnosis and prognosis. postoperative survival stratification based on radiomics feature and whole slide image feature may be useful for treatment decisions to improve prognosis. in this research, we aim to develop a deep learning-based prognostic-stratification system for automatic prediction of overall and cancer-specific survival in patients with blca.

bladder cancer can be difficult to diagnose and predict outcomes for, as the disease can vary greatly between patients. this research aims to develop a new system that uses artificial intelligence to analyze patient information, including images from surgery and scans. this system could then automatically predict a patient\&#39;s overall survival and how likely they are to survive specifically from bladder cancer. this information could be used by doctors to make better treatment decisions for each patient.

Eligibility criteria:
inclusion criteria: * patients with bladder cancer who had surgery like radical cystectomy or transurethral resection of bladder tumour (turbt) * contrast-ct scan less than two weeks before surgery * complete ct image data and clinical data * complete whole slide image data exclusion criteria: * patients with a postoperative diagnosis of non-urothelial carcinoma * poor quality of ct images * incomplete clinical and follow-up data

Keywords: deep learning radiomics histopathological tissue slides tomography
to study and compare the clinical course and development of organ failure in severe acute hepatitis without ascites, non-cirrhotic and cirrhotic patients with ascites [acute on chronic liver failure] and acute deterioration of previously decompensated cirrhosis.

Conditions: Cirrhosis

Summary: the study will be conducted on patients admitted to department of hepatology from march 2015 to december 2016 at ilbs, new delhi.all patients presenting to ilbs fulfilling the inclusion criteria will be included in the study and will be categorized and evaluated. the patient will followed over a period of 3 months.


Eligibility criteria:
inclusion criteria: * all consecutive patients presenting to hospital with bilirubin ≥5 and inr≥1.5 * cirrhosis with or without decompensation presenting with acute deterioration in less than 3 month exclusion criteria: * cirrhosis with chronic decompensation. * patient on anticoagulant * hepatocellular carcinoma * septic shock * post-liver transplant or resection
emotion and motivation in patients with psychosis

Conditions: Schizophrenia

Summary: anhedonia and avolition reflect emotional and motivational disorders, respectively. however, if these disorders play a major role in the symptomatology of schizophrenia, their mechanisms remain poorly understood, and existing treatments are inefficient on these symptoms. the literature suggests that the impairment does not concern emotion or motivation per se, but rather their influence on cognition. this project aims at using recent advances in the fundamental domain to better understand the cognitive and neuronal mechanisms of the patients' alterations, and especially how emotion and motivation influence cognition in schizophrenia.


Eligibility criteria:
inclusion criteria: * diagnostic and statistical manual of mental disorders criteria for schizophrenia exclusion criteria: * addiction problem * invalidating visual sensory problems * neurological history * for the healthy volunteers: psychiatric history

Keywords: emotion motivation cognition schizophrenia