Kornimate/medical-research-clean huggingface dataset:
game-based pediatric diabetes education

Conditions: Diabetes Mellitus, Type 1; Behavior, Health

Summary: the goal of this study is to evaluate the impact of a mobile app video game called digital vaccine for type 1 diabetes (dvx-t1d)™, proposed as a low-risk, non-invasive, digital therapeutic candidate for behavior change in children 6 to 12 years of age with type 1 diabetes (t1d). the investigators hypothesize that adoption of dvx-t1d™ by t1d patients will positively influence healthy dietary and physical activity behaviors by providing nutrition and lifestyle education through a playful, artificial intelligence (ai)-based, cartoon-style medium of mobile gaming, and result in improvements in their t1d control. the investigators propose to conduct a longitudinal randomized controlled trial (rct) over a 3-month period with a study population of 80 t1d participants (40 each in two arms of the trial) of 6-12 years old. the investigators will quantify the impact of the mobile game app plus standard care vs. standard care (with no exposure to the app) on t1d control (assessed by glycosylated hemoglobin or hba1c measured during clinic visits and continuous glucose monitoring (cgm) parameters measured at home), physical activity levels and food choices of children (measured using food logs and surveys). game telemetry, food logs, clinical, anthropometric, demographic, and survey data will be collected to obtain adequately powered, theory-driven evidence of the value of game-based approaches delivered via mobile apps.

youth with t1d who comply with inclusion criteria and provide consent will be randomized to either the treatment arm (will be given a tablet with the game) or the control arm (no tablet will be given, no exposure to the game). participants in both arms will continue receiving standard of care treatment. participants will be asked to maintain food and activity logs and answer questionnaires about lifestyle. participants will be evaluated at baseline and at 3 months with interim contact in between. devices will be downloaded to collect app usage data (game telemetry). exposure time will be tracked by the application. survey to elicit barriers and challenges encountered during the study will also be conducted.

Eligibility criteria:
for youth: * be between the age of 6 to 12 years. * have been diagnosed with type 1 diabetes for at least 1 year. * be currently taking insulin through multiple daily injections or an insulin pump. * check blood sugar with a meter at least 4 times per day or use a continuous glucose monitor. * be willing to comply with all study visits and procedures. for parent: * biological or adopted parent with custody and medical decision making of the patients * living with identified patients * over 18 years old * resident of allegheny county exclusion criteria: -children with type 2 diabetes, cystic fibrosis related diabetes, or secondary diabetes.

Keywords: app game children pediatrics
comparison of stroke volume variation-guided normovolemic and restrictive fluid management during craniotomy: a randomized controlled trial

Conditions: Supratentorial Neoplasms; Brain Tumor, Primary; Craniotomy

Summary: fluid management during neurosurgery presents a special clinical agenda. volume overload can have detrimental effects on intracranial pressure by increasing either cerebral blood volume or hydrostatically driven cerebral edema formation. on the other hand, an overt restrictive fluid strategy may risk hemodynamic instability. recently, dynamic fluid responsiveness parameters such as stroke volume variation (svv) have been shown as a more precise parameters for fluid management including in neurosurgical patients. the threshold of svv is reported about 10-15%. in this study, the investigators aim to using two svv threshold to conduct intraoperative fluid therapy for craniotomy. randomization will be generated by computer sampling. one of the two groups of patients will be managed with fluid bolus to keep intraoperative svv \<10% presenting the "normovolemia" group. the other group of patients will be kept intraoperative svv \<18% which is slightly above previously reported svv threshold upper limit. the second group thus presents the "restrictive" group. clinical outcomes, laboratory analysis including s100-b for neuronal damage and neutrophil gelatinase-associated lipocalin (ngal) for acute kidney injury, will be compared.


Eligibility criteria:
inclusion criteria: * supratentorial brain tumor receiving elective craniotomy * bmi between 18.5-27.0 kg.m-2 exclusion criteria: * cardiac dysfunction, such as coronary artery diseases; atrial fibrillation; * nyha class ii * renal dysfunction, egfr\< 60 ml.min-1.1.73m-2 * pulmonary cormorbidity, such as copd

Keywords: fluid therapy neurosurgery
point-of-delivery prenatal test results through mhealth to improve birth outcome

Conditions: HIV; Sickle Cell Disease; Hepatitis B

Summary: the investigators propose to adopt sustainable community networks (in this case churches) to implement an integrated community-based screening that incorporates mobile health technology (mhealth) to make prenatal test results available at the point-of-delivery to guide medical management.

the investigators will develop and test the feasibility, acceptability, and usability of a mobile health platform that captures results for hiv, hepatitis b virus (hbv) and sickle cell genotype obtained from participants during the healthy beginning initiative (hbi) program; store data in a secure, web-based database; encrypt data on a "smart card" which is given to participants, and make these data available at the point-of-delivery using a cell-phone application to read the "smart card". data on the web-based database can also be accessed directly using the cell phone application. evidence exists that when clinician have maternal records available at the point of delivery, they are more likely to initiate antiretroviral prophylaxis for hiv-exposed infants, administer the first dose of hepatitis b vaccine with 24 hours for infants born to women who have positive hepatitis b surface antigen and screen infants born to mothers with sickle cell trait to allow early identification and initiation of penicillin prophylaxis for infants who have sickle cell disease.

Eligibility criteria:
inclusion criteria: * pregnant women; 18 years or older enrolled in the healthy beginning initiative * one of the three conditions - hiv, hepatitis b, and sickle cell trait/disease exclusion criteria: * those who do not accept to have their information uploaded on the secure database

Keywords: mobile health technology
plaque burden and ischemia in minoca

Conditions: MINOCA

Summary: the goal of this clinical trial is to assess coronary artery plaque burden, perivascular inflammation and extent of myocardial ischemia in patients presenting with acute myocardial infarction and non-obstructive coronary artery disease. the main question it aims to answer are: * identify coronary artery anatomy, plaque burden, composition and high-risk plaque features by ct coronary angiography in minoca * assess presence, extent and severity of myocardial ischemia in minoca participants will examined by ct coronary angiography and stress \[12n\] nh3 pet-mr.


Eligibility criteria:
inclusion criteria: * acute chest pain * elevated troponin * non-obstructive coronary arteries by coronary angiography exclusion criteria: * obstructive coronary artery disease * contraindications against ct coronary angiography or stress \[12n\] nh3 pet-mr * not able to give informed consent
paritaprevir/r - ombitasvir, ± dasabuvir, ± ribavirin in patients with chronic hepatitis c - an observational study in austria (real)

Conditions: Chronic Hepatitis C

Summary: the study seeks to provide evidence of the effectiveness and obtain patient reported outcome (pro) and work productivity data of the interferon-free abbvie regimen (ombitasvir/paritaprevir/ritonavir +/- dasabuvir) +/- ribavirin (rbv) in chronic hepatitis c virus (hcv) infected participants in austria.


Eligibility criteria:
inclusion criteria: treatment-naïve or -experienced adult male or female patients with confirmed chronic hepatitis c, genotype (gt)1 or gt4, receiving combination therapy with the interferon-free abbvie regimen ± ribavirin (rbv) according to standard of care and in line with the current local label if rbv is co-administered with the abbvie regimen, it has been prescribed in line with the current local label (with special attention to contraception requirements and contraindication during pregnancy) patients must voluntarily sign and date a patient authorization to use and disclose his/her anonymized health data prior to inclusion into the study patient must not be participating or intending to participate in a concurrent interventional therapeutic trial exclusion criteria: none

Keywords: paritaprevir dasabuvir ombitasvir chronic hepatitis c hcv
comprehensive assessment in a longitudinal study on young men who have sex with men attracting to chemsex

Conditions: ChemSex Users for YMSM; ChemSex Users

Summary: the study is a two-phase observational study that assess multiple aspects of study and young men who have sex with men (ymsm). phase i of the study will be a cross-sectional descriptive study using a mixed methods data collection (focusing on qualitative data collection) to acquire information necessary for developing a more extensive study on the same matter. phase ii of the study will be a prospective cohort study using a quantitative data collection. findings from phase i will guide the development of phase ii which consist of a larger number of ymsm, important baseline and follow-up questionnaires and comorbidities assessments, sexually transmitted infections testing, and integration to care. this protocol exclusively addresses the phase i of the study. once the phase i findings are finalized, the principal investigator will submit the phase ii to the irb of the faculty of medicine, chulalongkorn university.


Eligibility criteria:
inclusion criteria: group 1a: current chemsex users 1. men who have sex with men 2. aged 16-35 years 3. able to communicate in thai fluently 4. current chemsex users 5. provide informed consent inclusion criteria: group 1b: former chemsex users (discontinued ≥90 days) 1. men who have sex with men 2. aged 16-35 years 3. able to communicate in thai fluently 4. former chemsex users (discontinued ≥90 days) 5. provide informed consent exclusion criteria: no exclusion criteria for all groups of participants

Keywords: chemsex users
ursodeoxycholic acid in the treatment of intrahepatic cholestasis of pregnancy

Conditions: Intrahepatic Cholestasis; Pregnancy

Summary: the purpose of this study is to examine the efficacy and safety of ursodeoxycholic acid (udca) in the treatment of patients with intrahepatic cholestasis of pregnancy (icp). in the randomised (double-blind, placebo-controlled) study 20 pregnant women with icp received (random allocation of) either 450 mg/day udca or placebo for 14 days during the third trimester of pregnancy. the severity of pruritus was registered. itching scores and serum levels of alanine aminotransferase, total bile acids, estradiol, progesterone, prolactin, cholesterol, hdl-cholesterol, triglycerides, activated partial thromboplastin time (aptt), fibrinogen d-dimers (fidd) and platelet count were assessed before the treatment and weekly thereafter. data on pregnancy and delivery outcome was recorded and analysed.


Eligibility criteria:
inclusion criteria: * pregnant women with intrahepatic cholestasis of pregnancy

Keywords: ursodeoxycholic acid intrahepatic cholestasis pregnancy
genomic-based diagnosis, classification and targeted treatment of multiple myeloma

Conditions: Multiple Myeloma

Summary: multiple myeloma is an incurable bone marrow cancer characterized by an abnormal expansion of plasma cells that secretes monoclonal immunoglobulin. over the years, the molecular and genetic heterogeneity of the disease have been dissected. with the maturation of technologies, the time is ripe now to apply genomics to diagnose, classify, risk-stratify and prognosticate myeloma in the clinical setting and use this information to guide current treatment. the investigators hypothesize that the use of gene expression profiling as a single test will be more economical, efficient and accurate compared to the current standard panel of tests done at diagnosis. the investigators also hypothesize that the investigator can use predictive markers to identify prospectively patients who will respond to velcade and that with more effective trebasedonatment, ability to measure depth of response beyond conventional complete response become important since more patients are achieving conventionally determined complete response. using a cohort of patients treated on a standard treatment protocol based on velcade-based induction treatment followed by consolidation and maintenance treatment, the investigators will study specifically the feasibility and accuracy of gene expression diagnostics, the predictive power of the investigators predefined predictive markers and the clinical utility of minimal residual disease measurement in myeloma. the results of the investigators study will allow us to improve the diagnosis, and prognostication of mm patients 1. the investigators hypothesized that this will speed up diagnosis, provide comprehensive information for the classification and risk stratification of mm patients and can completely replace the current fish assay and may be cheaper. 2. the investigators hypothesized that traf3 deletion or mutation and myc activation will identify patients that will have a significantly better response to velcade. 3. modern treatment induced deeper response. more sensitive method of disease detection will allow us to know the fully extent of response to these treatment


Eligibility criteria:
inclusion criteria: * all patients fulfilling imwg diagnostic criteria for myeloma exclusion criteria: * unable to take consent
saccadic eye movements are impaired in glaucoma

Conditions: Glaucoma, Open-Angle

Summary: the purpose of this study is to determine whether rapid eye movements called saccades are impaired in glaucoma, a neurodegenerative disease of visual pathways.

eye movements that quickly scan a visual scene are critical to a number of daily activities including driving. it is not known whether rapid eye movement called saccades, are altered in glaucoma.

Eligibility criteria:
inclusion criteria: * ages from 40-80 years. primary open angle glaucoma is defined by characteristic glaucomatous optic nerve head findings and the presence of corresponding visual field deficits in one or both eyes. all control subjects will be age-matched, with no ocular medical or surgical history, and a completely normal eye examination. age-matched controls will be recruited from local hospital personnel and accompanying relatives. exclusion criteria: * any patient with a history of other eye disease, neurological disease or neurodegenerative disorder, or history of incisional ocular surgery within the previous month will be excluded.
active video games to promote physical activity in children with cancer

Conditions: Cancer

Summary: the aim of this study is to evaluate the efficacy and feasibility of active video gaming with regard to the promotion of physical activity and motor learning in children with cancer. experienced fatigue, body mass index and the development of metabolic risk factors during treatment are also examined.


Eligibility criteria:
inclusion criteria: * cancer diagnose * treated with vincristine in turku university hospital or tampere university hospital exclusion criteria: * other diseases limiting functional ability * not able to communicate
evaluation of nocturnal enuresis and barriers to treatment among pediatric patients with sickle cell disease

Conditions: Sickle Cell Disease

Summary: pediatric patients with sickle cell disease are at greater risk for exhibiting nocturnal enuresis (bedwetting) compared to the general population. this increased risk has been attributed to a decreased ability to concentrate urine caused by sickling-induced nephropathy. the sociodemographic, psychosocial, and medical factors associated with nocturnal enuresis are not well defined. in addition, the impact of these behaviors on emotional and behavioral functioning, along with health-related quality of life are not clear. despite the availability of evidence-based interventions for nocturnal enuresis, very few families with a child with sickle cell disease have utilized these methods. the reasons for this underutilization of interventions are not clear.

primary objective: to examine differences between those who do and those who do not exhibit nocturnal enuresis in regard to health-related quality of life, emotional and behavioral functioning, family functioning, stressful life events, sociodemographic factors and medical factors. secondary objective: to identify barriers to intervention implementation for nocturnal enuresis. in this study, children and adolescents with sickle cell disease ages 6-18 years and their parents/guardians will each complete an interview with questionnaires assessing nocturnal enuresis, health-related quality of life, emotional and behavioral functioning, family functioning, and stressful life events. participants who report nocturnal enuresis will identify interventions they have used in the past, along with barriers to intervention implementation. the future goal will be to use this information to develop an effective intervention strategy for nocturnal enuresis specific to the needs of children and adolescents with sickle cell disease.

Eligibility criteria:
inclusion characteristics: * child characteristics: * st. jude children's research hospital (sjcrh) patient with a primary diagnosis of sickle cell disease (hbss, hbsc, hbsβ0thalassemia, hbsβ+thalassemia) * age 6.0-17.99 years at the time of enrollment * primary language is english * has the cognitive capacity to complete questionnaires * caregiver characteristics: * parent or guardian of sjcrh patient who meets above criteria * primary language is english * has the cognitive capacity to complete questionnaires exclusion criteria: * child characteristics: * experiencing current acute complications of sickle cell disease requiring hospitalization or an acute care visit (e.g., pain crises, acute chest syndrome, acute cerebrovascular events/stroke or active infection/fever). * caregiver characteristics: * has a child experiencing current acute complication of sickle cell disease, such as pain crisis, acute chest syndrome, stroke, or infection.

Keywords: nocturnal enuresis barriers to treatment
the impact of interscalene block on sleep disordered breathing

Conditions: Sleep Disordered Breathing; Obstructive Sleep Apnea

Summary: this is a randomized controlled trial evaluating the impact of interscalene block on worsening of upper airway collapse in sleep disordered breathing for patients undergoing ambulatory shoulder surgery.

sleep disordered breathing (sdb), closely associated with obesity, is a highly prevalent, serious, and often unrecognized breathing disorder resulting from repeated upper airway collapse, decreased oxygen levels, and a very high risk of life threatening complications at the time of surgery. current guidelines recommend using regional as opposed to general anesthesia in sdb patients to minimize risks and the use of strong narcotic medications. it is unclear whether interscalene block in use for analgesia (pain relief) may actually worsen the severity of sdb by invariably freezing the phrenic nerve, thereby temporarily paralyzing the diaphragm. this novel clinical trial will examine whether or not isb increases the rate of upper airway obstruction or collapse during sleep and other dangerous postoperative complications seen in patients with sdb following shoulder surgeries. the primary objective of the study is to evaluate the impact of isb on the oxygen desaturation index (sleep apnea severity) in untreated sdb patients undergoing ambulatory shoulder surgery compared to patients who do not receive isb. secondary objectives are: 1) to evaluate the impact of hemidiaphragmatic paresis on impairment in pulmonary function; 2) to evaluate the impact of impairment in pulmonary function on the oxygen desaturation index (odi); 3) to assess the incidence of important perioperative clinical outcomes such as hypoxemia, recurrent respiratory events, delayed discharge, and resource utilization in sdb patients undergoing ambulatory shoulder surgery compared to patients who do not receive isb; and 4) to assess important analgesia related outcomes such as: time to onset of pain, intraoperative and postoperative opioid consumption, hourly and daily vas pain scores, opioid related side effects, patient satisfaction with analgesia, and presence/absence of nerve block complications.

Eligibility criteria:
inclusion criteria: * adult patients ( \>18 to 80 years); * american society of anesthesiology (asa) physical status i-iv; * undergoing elective ambulatory shoulder surgery such as shoulder replacement, acromioplasty, rotator cuff repair, or bankart procedure under general anesthesia. exclusion criteria: * past history of head, neck or thoracic surgery (e.g., osa corrective surgery); * pregnancy or lactation; * phrenic nerve stimulators; * local anesthetic allergy; * previous diaphragmatic paralysis; * inability to communicate with health care providers or the research personnel, inability to perform breathing maneuvers such as spirometry, or inability to follow instructions.

Keywords: sleep apnea
assessment of colonic epithelial integrity with mucosal impedance

Conditions: Inflammatory Bowel Diseases

Summary: in this study, the investigators propose to use mucosal impedance (mi), a minimally invasive technology, to detect mucosal damage (i.e. barrier dysfunction) based on mucosal conductivity changes in the colonic epithelium.

the intestinal epithelium functions to separate luminal contents from the interstitium. increased intestinal permeability can represent compromise of the epithelium's integrity. prior research has demonstrated that defects in intestinal barrier function are associated with inflammatory bowel disease (ibd) and increased intestinal permeability can be important in the maintenance of remission in ibd patients. there is currently not a convenient way to measure colonic epithelial barrier function in real time which could provide clinically relevant information .

Eligibility criteria:
inclusion criteria: * men and women over the age of 18 with a diagnosis of ibd (ulcerative colitis or crohn's disease) * men and women undergoing screening colonoscopy (typical age would be 50 or greater but there are exceptions) exclusion criteria: * age less than 18 years old * patients unable to give informed consent * patients with history of colonic surgeries * patients with history of colonic motility disorder
validation of software-based fusion of ultrasound and mri images of the prostate

Conditions: Prostate Cancer

Summary: the investigators hypothesize software-based fusion/navigation will be accurate to within 3 mm of the reference standard of em fusion. the investigators aim to evaluate the accuracy of prostate us/mri software-based fusion/navigation technology.


Eligibility criteria:
inclusion criteria: * scheduled for ultrasound-guided gold seeds prostate fiducial placement prior to radiotherapy exclusion criteria: * egfr \< 45 ml/min/1.73m2 * recent (within 4 weeks) kidney or liver transplant * contraindication to prostate mri * patient with cardiac pacemaker

Keywords: radiology