Kornimate/medical-research-clean huggingface dataset:
effect of intermittent hepatic inflow occlusion during donor hepatectomy in living donor liver transplantation

Conditions: End Stage Liver Disease; Living Donor

Summary: intermittent hepatic inflow occlusion (ihio), also called pringle maneuver, is a safe and effective procedure for major hepatectomy in patients with liver disease. in addition, ischemic preconditioning with ihio has been reported to have protective effects in patients undergoing liver resection. the role of ihio, however, has not been fully elucidated in donors and recipients during living donor liver transplantation.

intermittent hepatic inflow occlusion (ihio) by clamping of the portal triad, also called pringle maneuver, is a safe and effective procedure in major hepatectomy in patients with liver disease. ihio minimizes blood loss and operation time during liver resection. in addition, ischemic preconditioning with ihio has been reported to have protective effects in patients undergoing liver resection. in the setting of living donor liver transplantation (ldlt), one of the most important concerns is liver donor safety. several studies have shown the safety of ihio in donors for liver transplantation (lt). however, the effect of preconditioning with ihio during donor hepatectomy on ldlt recipients remains unclear. several small series have assessed the effects on recipients of ischemic preconditioning during whole liver transplantation from deceased donors. the role of ihio, however, has not been fully elucidated in liver donors and recipients during ldlt. in this randomized, prospective study, we'll evaluate the efficacy of ihio in the recipients and donors.

Eligibility criteria:
inclusion criteria: * donors and recipient of ldlt, saged ≥18 years, who will undergo ldlt with donors undergoing right hemihepatectomy and recipients receiving right hemiliver grafts * informed consent agreement exclusion criteria: * if the recipients has fulminant hepatic failure * if the graft to recipient body weight ratio (grwr) is \<0.9 * if a frozen biopsy of the donor liver taken prior to donor hemihepatectomy shows \>30% macrovesicular steatosis * if liver transplantation is abo incompatible * if recipients has received previous organ transplants * if recipients has received or were scheduled to receive multi-organ transplants
tep versus open repair of sportsman's hernia

Conditions: Chronic Pain; Bone Marrow Oedema

Summary: sportsman's hernia causes chronic groin pain in physically active adults. open hernia repair without mesh or laparoscopic technique with mesh have been advocated in the treatment of sportsman's hernia. the aim of this randomized study is to compare the effectiveness of open technique to laparoscopic technique for the treatment of sportsman´s hernia. the hypothesis is that laparoscopic technique is less painfull than open surgery for repair of sportsman's hernia.

sportsman's hernia is defined as a weakness or disruption of the posterior wall of the inguinal canal. open hernia repair with or without mesh or laparoscopic techniques with mesh have been advocated in the treatment of sportsman's hernia and associated athletic pubalgia. the results of the operative treatment from single centers are reported to be good to excellent in between 70 - 90% of patients with the most promising results reported using an open minimal repair (omr) technique. there are no randomized trials comparing open versus laparoscopic techniques regarding time for recovery and relief of pain. the aim of this randomized study is to compare the effectiveness of omr technique in local or spinal anesthesia to endoscopic total extraperitoneal (tep) technique in general anesthesia for the treatment of sportsman´s hernia/athletic pubalgia. the primary endpoint is patient being free from intractable groin pain during sports activity or daily work four weeks after surgery.

Eligibility criteria:
inclusion criteria: * males/females professional or non-professional athletes * age 18-50 years * unilateral or bilateral groin pain lasting \> 6 weeks * physical examination and mri indicating sportsman's hernia * pain above inguinal ligament in the deep inguinal ring * grade i-ii edema at pubic symphysis on mri scan is allowed exclusion criteria: * patients not willing to participate * inguinal or femoral hernia * mri reveals other major pathology * former surgery to the actual groin * allergy to polypropylene or other contra-indication to surgery

Keywords: sports hernia sportsman's hernia chronic groin pain open minimal repair totally extraperitoneal endoscopic technique
ioxaglate versus iodixanol for the prevention of contrast-induced nephropathy in high-risk patients (idpc trial)

Conditions: Acute Kidney Failure

Summary: contrast media-induced nephropathy following diagnostic and therapeutic cardiac catheterization.

contrast-induced acute kidney injury represents a serious complication of procedures requiring administration of iodinated contrast media and is associated with the need for dialysis, prolonged hospitalization, increased costs, and mortality. contrast-induced nephropathy is defined as an increase of 25% in serum creatinine before the procedure. iodixanol, a nonionic, dimeric, iso-osmolar contrast medium may be less nephrotoxic than low-osmolar contrast media in high-risk patients. the purpose of this study is to compare iodixanol versus ioxaglate in high risk patients between 48 and 96 hours after procedures that use contrast.

Eligibility criteria:
inclusion criteria: at least one of the following criteria * aged more than 70 years-old * chronic renal failure * diabetes mellitus * congestive heart failure - left ventricular ejection fraction \< 0.50 * shock or intra-aortic ballon pump use * urgency or emergency procedures exclusion criteria: * patients in dialysis * allergy to iodine * patient refusal to informed consent

Keywords: nephropathy catheterization contrast media ioxaglate iodixanol high risk prevention
a standard music program compared to an optimized music program

Conditions: Hearing Loss

Summary: the trial will test whether a standard music program that is an offset to the general program provides the same benefit as a music program that is individually customized for each test participant. the trial seeks to investigate the benefit received by musicians that regularly play an instrument and belong to an organized music group or orchestra instead of people that listen to music.

the initial goal of hearing aids is to amplify speech and facilitate speech understanding especially in noise. besides speech difficulty, people with hearing loss also report a reduced enjoyment of music. the hearing aid settings used for amplifying speech often have adverse effects on music. for this study, the sponsor will carry out testing with participants with hearing loss to compare dedicated music programs. the current study will compare the standard music program available in the software to one that is fine-tuned for each subject. the hearing aids that will be used for the study are certified by the european conformity and have been on the market for almost one year. the goal is to determine whether musicians will perceive a difference and prefer a fine-tuned music program over the default music program in real-life situations.

Eligibility criteria:
inclusion criteria: * all classifications of hearing loss (sensorineural, conductive, mixed) * if conductive or mixed, approval for amplification by a physician is needed * all shapes of hearing loss (flat, sloping, reverse slope, notch) * severity ranging from mild to profound * german or french speaking * play a musical instrument * ability and willingness to sign the consent form exclusion criteria: * normal hearing * contraindications for amplification * active ear disease * don't play an instrument * inability to follow the study procedures due to language problems, psychological disorders, dementia, or other cognitive problems * unable to attend study appointments due to reduced mobility * reduced ability to describe auditory impressions and usage of hearing aids * uncooperative so that it is ot possible to record a valid audiogram * severely reduced dexterity * central hearing disorders * sponsor employees * family members of employees of the sponsor
use of fenofibrate for primary biliary cirrhosis

Conditions: Primary Biliary Cirrhosis

Summary: this is a pilot study to evaluate the safety and efficacy of fenofibrate on patients with primary biliary cirrhosis who have an incomplete response to ursodeoxycholic acid.

this is a multicenter open label pilot study to evaluate the efficacy of fenofibrate in 20 patients with pbc treated for 1 year. a randomized design would not be feasible at this stage of the research. two sites are enrolling patients: university of florida, gainesville, and mayo clinic rochester, with the first as the coordinating site. the total number of patients to start treatment will not exceed 20. our endpoints are 1) surrogate markers of disease activity -serum alkaline phosphatase and immunoglobulin m; 2) a well validated prognostic index -mayo risk score and 3) the niddk quality of life questionnaire.

Eligibility criteria:
inclusion criteria: * established diagnosis of pbc by serological (positive antimitochondrial antibodies) and/or histological evidence (diagnostic liver biopsy) * previous treatment with udca 13-15 mg/kg/day for at least 1 year * persistent elevation of serum alkaline phosphatase ≥ 2 times the upper limit of normal on two separate measurements * female patients of childbearing age should have a pregnancy test done within -days of the beginning of this trial, and should agree to be on adequate contraception throughout the study period * signed informed consent after careful review of the information and study details by one of the investigators exclusion criteria * hypersensitivity to fenofibrate * prisoners and institutionalized subjects * pregnant or nursing women * anticipated need for liver transplantation in one year (estimated one year survival \< 80%) as determined by the mayo risk score. the mayo risk score takes into account the patient's age, serum bilirubin, albumin and prothrombin time, as well as presence or absence of peripheral edema. * recipients of liver transplantation * recurrent variceal hemorrhage, uncontrolled encephalopathy or refractory ascites * co-existing liver diseases, such as primary sclerosing cholangitis, acute or chronic hepatitis, alcoholic liver disease, choledocholithiasis, autoimmune hepatitis, cholangiocarcinoma * acute or chronic renal failure * known history of cholecystitis with intact gallbladder * current use of statins, as the concomitant use of fibrates and statins would increase the risk of toxicity

Keywords: pbc primary biliary cirrhosis fenofibrate triglide
wb-ems and individualized nutritional support in gynecological cancer patients

Conditions: Gynecologic Cancer; Cachexia

Summary: this study evaluates the effects of a 12-week whole-body electromyostimulation (wb-ems) training combined with individualized nutritional support on body composition, muscle strength and function, quality of life, fatigue and inflammatory status on patients with gynecological cancer undergoing palliative anti-cancer treatment. furthermore, this study assesses the effect of this combined therapeutic approach within a 3 to 4-week pre-operative study intervention on the period of hospitalization in gynecological patients undergoing curative anti-cancer treatment.


Eligibility criteria:
inclusion criteria: * female patients with gynecological cancer undergoing palliative or curative treatment * 18 years and older * ecog status \> 2 exclusion criteria: * simultaneous participation in other nutritional or exercise intervention trials or in the past 6 months * acute cardiovascular events * use of anabolic medications * epilepsy * severe neurological diseases * skin lesions in the area of electrodes * energy active metals in body * pregnancy * acute vein thrombosis * rheumatic diseases * pregnant and nursing women * psychiatric disorders with doubts about legal and cognitive capacity

Keywords: gynecologic cancer wb-ems whole-body electromyostimulation nutrition protein exercise cancer cachexia
echocardiographic manifestation in patient with covid-19 （early-myo covid-19）

Conditions: Covid19; Echocardiography

Summary: the cardiovascular effects of coronavirus disease 2019 (covid-19) are not yet fully known. we conducted a prospective and dynamic echocardiographic study to investigate the cardiac structural and functional changes in covid-19 patients in intensive care unit (icu).

the ongoing pandemic of coronavirus disease 2019 (covid-19) caused by the newly discovered severe acute respiratory syndrome coronavirus 2 (sar-cov-2) has become a global health crisis, resulting in 3,435,894 confirmed infections and 239,604 deaths worldwide by 4 may 2020 1. although acute respiratory syndrome is the main manifestation of the disease2, the understanding of the impact of the virus on other organs is of importance in terms of multiple organ dysfunction/failure that contributed to the increased mortality in patients with covid-19. with the increase of confirmed cases and the accumulation of clinical data, the cardiovascular manifestations caused by covid-19 has raised concern3. some studies have reported that a certain percentage of patients presented cardiac injury as indicated by elevated cardiac biomarkers such as high-sensitivity cardiac troponin-i (hs-ctni) and brain natriuretic peptide (bnp) 2,4,5. cardiac complications, including acute heart failure, cardiac rupture and even sudden cardiac arrest, has also been described in several case reports 6-8. however, autopsy studies failed to find the evidence of direct assaults by the virus in myocyte or apparent myocyte necrosis/apoptosis in the heart 9. typical pathological finding reported was mononuclear inflammatory infiltration in the myocardial interstitium but no substantial damage in cardiomyocytes in the heart 10,11. thus, a significant gap exists in our knowledge between the clinical investigation and postmortem findings. at present, the in vivo morphological and functional features of cardiac injury remain unknown. we therefore performed a prospective and dynamic echocardiography study to investigate the cardiac structural and functional changes in patients with covid-19 who were admitted to intensive care unit (icu), and to compare the cardiac characteristics between deceased and survived patients.

Eligibility criteria:
inclusion criteria: patients had been diagnosed of covid-19 according to the criteria established by the who interim guidance and admitted to icu because of severe or critical condition exclusion criteria: patients who were \< 18 years and whose entire stay in hospital lasted for \< 48 hours.

Keywords: covid-19 echocardiography cardiac structure cardiac function
study on the effectiveness of berlin dissexuality therapy as part of the model project in accordance with §65d sbg v

Conditions: Paedophilia; Hebephilia

Summary: the main goal of this clinical trial is to learn if psychotherapy works to reduce consumption of child abuse imagages.


Eligibility criteria:
inclusion criteria: * age at first presentation minimum 18 years * voluntary consent to participation on the part of the participant * at the time of inclusion, no contact with the justice system (ongoing investigation, ongoing criminal proceedings, ongoing prison sentence) due to sexually abusive behavior towards children * sexually conspicuous behavior and/or fantasies or impulses that indicate the presence of a pedophilic and/or hebephilic preference disorder. * an offer of treatment is made when a suspected diagnosis is confirmed or the diagnosis is confirmed * feared or recent use of abusive images * sufficient knowledge of german * voluntary participation in the study and checking the checkbox in the informed consent form before starting participation exclusion criteria: * age under 18 years * lack of consent on the part of the patient * exclusion of the presence of a pedophilic and/or hebephilic preference disorder * current legal status in the sense of an ongoing investigation or criminal proceedings due to sexually assaultive behavior towards children * severe comorbidities: unstable psychotic disorder, organic brain damage, reduced intellectual capacity (iq below 70), untreated drug or alcohol addiction or persistent harmful use * current risk of child sexual abuse and or child sexual abuse that occurred less than 15 years before the start of the study * an antiandrogenic medication or an opiate antagonist, during therapy start taking a serotonin reuptake inhibitor.

Keywords: paedophilia hebephilia child abuse images sexual offending
feasibility of adaptive radiation therapy for human-papilloma virus-positive oropharyngeal cancer patients on mridian linac

Conditions: Oropharynx Cancer

Summary: the purpose of this research is to determine whether it is feasible to treat patients with human papilloma virus positive (hpv-positive) oropharyngeal tumors on a specialized treatment machine (mridian linear accelerator \[linac\]), which utilizes magnetic resonance imaging (mri) for radiation planning and delivery.


Eligibility criteria:
inclusion criteria: * pathologically confirmed new diagnosis of hpv-positive opc \[i.e. base of tongue, tonsil, soft palate, vallecula, and posterior pharyngeal wall\] * american joint committee on cancer (ajcc) 8th edition stage i-iii planned for definitive chemoradiation. * members of all races and ethnic backgrounds * women of childbearing potential and men must agree to use adequate contraception prior to study entry and for duration of study participation. * must be able to understand and sign an institutional review board (irb)-approved written informed consent document. exclusion criteria: * prior surgery, chemotherapy, or radiation treatment for head and neck cancer * prior history of cancer other than non-melanomatous skin cancer * distant metastases (cm1) or (pm1) disease) * evidence of a compromised airway * medical contraindications to mris * unable to tolerate mris without sedation * pregnant patients * breastfeeding patients * eastern cooperative oncology group (ecog) performance status \>1
increasing knowledge on osteogenesis imperfecta by collecting epidemiological data

Conditions: Osteogenesis Imperfecta

Summary: interventional pilot study with the enrollment of patients affected by osteogenesis imperfecta

subjects diagnosed with osteogenesis imperfecta will be undergoing, after collection of informed consent, to a series of assessments using sensor imaging and gait-analysis and collection of specific parameters

Eligibility criteria:
inclusion criteria: * patients with osteogenesis imperfecta (clinical diagnosis) able to perform the gait-analysis movement data acquisition session, in the most complete instrumental configuration, i.e., with kinematics, dynamics and electromyography; it will naturally be evaluated which motor tasks are safely executable and which are not. * all patients of both sexes will be included * patients in the age range: 8-60 will be included exclusion criteria: * subjects who do not fit the inclusion criteria
clinical utility of electrical impedance spectroscopy

Conditions: Focus of Study: Patients With Suspicion of Melanoma

Summary: the purpose of this clinical study is to evaluate the clinical utility of the nevisense in normal clinical practice, i.e. the potential effect of implementing nevisense in clinical decision making (human vs human \& machine) based on nevisense measurement at time of biopsy decision.

this is a multi-center, prospective, blinded clinical study designed to evaluate clinical utility of nevisense in normal clinical practice, i.e. the potential effect of implementing nevisense in clinical decision making (human vs human \& machine) based on nevisense measurement after biopsy decision. the study enrollment will continue until minimum of 180 subjects are enrolled in the study. up to 3 us university/hospital investigational sites will participate in this study. biopsying clinician or the investigators from the clinical practices of physicians participating in the study will perform the patient and lesion assessment for biopsy as standard of care at the clinic. study subjects will be recruited from the clinical practices of physicians participating as investigators in this study. biopsying clinicians provide their assessment to whether s/he would have sent the lesion(s) for biopsy had s/he known the eis information beforehand . thereafter an evaluation of the suspicious lesion with the nevisense will be performed followed by a biopsy of the lesion. the biopsied lesion will be subjected to histological analysis.

Eligibility criteria:
inclusion criteria: * the lesion(s) meet criteria for nevisense evaluation. * lesions that present with unclear clinical presentation to allow for clinical diagnosis of benign or minimally dysplastic nevus (nevi) -thus, necessitating a biopsy. * lesions within nevisense indication for use: nevisense is indicated for use on cutaneous lesions with one or more clinical or historical characteristics of melanoma, when a dermatologist chooses to obtain additional information when considering biopsy. nevisense should not be used on clinically obvious melanoma. the nevisense result is one element of the overall clinical assessment. the output of nevisense should be used in combination with clinical and historical signs of melanoma to obtain additional information prior to a decision to biopsy. nevisense is indicated only for use on: * primary skin lesions with a diameter between 2 mm and 20 mm; * lesions that are accessible by the nevisense probe; * lesions where the skin is intact (i.e. non-ulcerated or non-bleeding lesions); * lesions that do not contain a scar or fibrosis consistent with previous trauma; * lesions not located in areas of psoriasis, eczema, acute sunburn or similar skin conditions; * lesions not in hair-covered areas; * lesions which do not contain foreign matter; * lesions not on special anatomic sites (i.e. not for use on acral skin, genitalia, eyes, mucosal areas). exclusion criteria: * subjects who fail to provide informed consent * study subjects with underlying medical disease which may alter ability to diagnose clinically or inhibit nevisense from collecting data