Kornimate/medical-research-clean huggingface dataset:
voice therapy for teachers with voice problems

Conditions: Phonotrauma

Summary: the study compares two different forms of voice therapy, lessac-madsen resonant voice therapy and casper-based confidential flow therapy. the target population are teachers because they have the highest risk for developing voice problems. for this study the investigators are primarily interested in seeing if lessac-madsen resonant voice therapy (lmrvt) and casper-based confidential flow therapy (cbcft) are equally effective at improving vocal functioning in teachers with phonotrauma, as assessed by the voice handicap index (vhi).


Eligibility criteria:
inclusion criteria: * full or part time teacher including college professor, daycare and preschool * 21 years of age and older * complaints of voice problems declared to be lasting continuously for one month or more * any structural or functional change to the larynx that appears related to phonation,including bilateral or unilateral lesions (assuming normal overlying epithelium based on clinical examination), non-specific edema, or erythema that appear by clinical history related to phonation, or primary muscle tension dysphonia or other condition related to phonation without lesions * no concurrent ear, nose and/or throat diagnoses, e.g. acute allergies, except for chronic allergies, sinusitis, and laryngopharyngeal reflux disease (lpr) * no vocal fold hemorrhage * no known degenerative medical conditions (e.g., degenerative neuromuscular disease, malignant process undergoing treatment or with less than 5 years remission, uncontrolled systemic disease (e.g., auto immune disease, or hormonal condition) * normal hearing to 30 db at 1000hz - 3000hz in the better ear * the participant is able to start therapy within 6 weeks of the initial evaluation and can be scheduled for 8 sessions (two per visit) in a 6-week time period * agreement by the participant to provide information regarding days missed from work during the previous year and the year following treatment exclusion criteria: * known degenerative medical condition * concurrent ear-nose-throat diagnosis, e.g., acute allergies (but chronic allergies, sinusitis, and laryngopharyngeal reflux disease (lpr) are not exclusion criteria) and vocal fold hemorrhage * degenerative medical conditions that would exclude a participant from participation include, but are not limited to: degenerative neuromuscular disease, malignant process undergoing treatment or with less than 5 years remission, uncontrolled systemic disease (e.g. auto immune disease), or hormonal condition.

Keywords: voice problems voice disorders
a clinical study of cht101 in cd70-positive relapsed or refractory hematological malignancies

Conditions: Peripheral T-cell Lymphoma; Cutaneous T-cell Lymphoma (CTCL); NHL (Non-Hodgkin Lymphoma)

Summary: evaluate the safety, pharmacokinetics and efficacy of cht101 in subjects with relapsed or refractory t or b cell hematological malignancies

3 planned dose cohorts will be evaluated during dose escalation phase. the dose expansion will be initiated after src (safety review committee) reviewing available safety, pk and preliminary efficacy data.

Eligibility criteria:
inclusion criteria (abbreviated): 1. willing and able to provide written informed consent. 2. aged 18 to 70 years, male or female. 3. confirmed cd70 positive in tumor tissue by immunohistochemistry (ihc). 4. only the following subtypes of hematological malignancies with measurable disease will be enrolled: 1. peripheral t cell lymphoma (including peripheral t cell lymphoma nos, angioimmunoblastic t cell lymphoma, anaplastic large cell lymphoma, etc.) who have failed ≥1 line of systemic therapy. 2. cutaneous t cell lymphoma (including mycosis fungoides (mf) or sézary syndrome (ss) \[stage ≥iib with disease involving two or more compartments or single-compartment disease with large-cell transformation\]) who have failed ≥2 lines of systemic therapies. 3. aggressive b cell lymphoma who are refractory or relapsed post ≥2 lines of systemic therapies which contain anti-cd20 antibody and anthracyclines. 4. indolent b cell lymphoma who are refractory or relapsed post ≥2 lines of systemic therapies which contain anti-cd20 antibody. 5. chronic lymphocytic leukemia (cll) who are refractory or relapsed post ≥2 lines of systemic therapies which contain btk inhibitor and bcl-2 inhibitor. 5. eastern cooperative oncology group (ecog) performance status of 0-1. 6. estimated life expectancy ≥12 weeks. 7. female patients of childbearing potential and male patients must agree to use a highly effective method of contraception from signing icf through 2 years after last cht101 infusion. exclusion criteria (abbreviated): 1. history or presence of cns metastasis, or clinically relevant cns pathology such as seizure, stroke, severe brain injury, etc. 2. history of solid organ transplantation. 3. prior treatment with cd70-targeting agents. 4. prior treatment with car-t or other cellular/gene therapies. 5. ongoing bacterial, viral or fungal infection requiring systemic anti-infectives. 6. active autoimmune disease requiring immunosuppression.
iop elevation study

Conditions: Intraocular Pressure

Summary: the purpose of this study is to improve understanding of the pathophysiologic process that leads to the development of glaucamotous damage. the mechanism by which vision loss in glaucoma occurs is still unknown, but it is clear that increased intraocular pressure (iop) is a major risk factor. it is also thought that the lc is a site of primary damage during pathogenesis of the disease. this prospective study with determine the in-vivo mechanical response to iop modulation at the level of the onh and lc.

the present study will briefly increase the pressure in eyes of living subjects and examine the effect of elevated intraocular pressure on optic nerve topography and position during pressure elevation using optical coherence tomography imaging of the posterior eye. outcome measures will include measurements in microns based on these images quantifying the deformation of the lamina cribrosa.

Eligibility criteria:
inclusion criteria: healthy volunteers * no family history (first degree relative) of glaucoma. * no history of iop \>22 mmhg. * normal appearing optic discs and rnfl on dilated fundus examination. * normal swedish interactive thresholding algorithm (sita) standard perimetry tests as defined by glaucoma hemifield test (ght) within normal limits. glaucoma suspects * normal visual field as defined above. * either iop between 25 to 30 mmhg with central corneal thickness \< 550µm, or a difference ≥ 0.2 in cup to disc ratio between eyes. glaucoma * glaucomatous onh abnormality: rim thinning, notching, undermining (excavation) or diffuse or localized rnfl defects that are characteristic of glaucoma. * two consecutive abnormal sita standard perimetry tests with ght outside normal limits. exclusion criteria: * media opacity (e.g. lens, vitreous, cornea). * strabismus, nystagmus or a condition that would prevent fixation. * diabetes with evidence of retinopathy. * previous intraocular surgery or ocular trauma (with the exception of laser procedures and subjects that have undergone uneventful cataract surgery more than 6 months from enrollment date). * neurological and non-glaucomatous causes for visual field damage. * any intraocular non-glaucomatous ocular disorders.
epidural electrical stimulation for spinal cord injury patients and corticospinal motor circuit improvement

Conditions: Spinal Cord Injuries

Summary: the study aims to examine the plausible interventional mechanisms underlying the effects of epidural spinal cord stimulation.

the purpose of this study is for the treatment of spinal cord injury (sci) paralysis patients use the signal by electrophysiological analysis of epidural spinal cord stimulation (scs) settings that promote limbs activity so that sci patients can restore motor ability under multiple sensory stimuli and multimodal electrical stimulation rehabilitation. the investigators hope to establish an atresia nerve regulation strategy and observe that the original blocked neural circuits can improve nerve plasticity by scs. even can establish new connections through residual nerves and allow sci patients to rebuild neural circuits without scs to restore limbs mobility and improve quality of life.

Eligibility criteria:
inclusion criteria: * sci asia: a, b, c,d * between 20 and 70 year of age * \>1 year post sci * complete or incomplete spinal cord injury. * expected will undergo spinal cord stimulation surgery. * continued rehabilitation after surgery for spinal cord injury. * able to comply with procedures and follow up. * stable medical condition without cardiopulmonary disease or dysautonomia that would - contraindicate participation in lower extremity rehabilitation or testing activities exclusion criteria: * have significant cognitive impairment (mmse\<24). * had a mental illness within one year or been treated in the past. * have major depressive disorder. * active cancer diagnosis. * painful musculoskeletal dysfunction, unhealed fracture, contracture, pressure sore, or urinary tract infection that might interfere with stand or step training. * cardiovascular or musculoskeletal disease or injury that would prevent full participation in physical therapy intervention. * unable to read and/or comprehend the consent form. * have concerns about this trial and do not sign consent.
sleep hygiene measures for sleep bruxism in children

Conditions: Sleep Bruxism, Childhood

Summary: the aim of the study is to evaluate the efficacy of sleep hygiene measures for the possible improvement of sleep bruxism in children through a randomized controlled clinical study of children under 8 years of age with probable sleep bruxism. in randomization both groups will receive information about bruxism, and the test group will receive instructions of sleep hygiene, limited use of screens and a relaxation audio. the occurrence of sleep bruxism will be assessed through a diary to be completed by the child's responsible party. a randomized, stratified sample of approximately 16 children will be included in the study. one group will be composed of 8 children with probable sleep bruxism who will receive the sleep hygiene intervention, and another group of children who will only receive instructions on sleep bruxism, with causes and consequences. participants will be followed-up for 30 days. parents will respond to a questionnaire about socioeconomic, demographic (child's age and gender), as well as parafunctional habits such as nail biting, biting objects, pacifier sucking, finger / thumb sucking and bottle feeding, child's sleep characteristics, screen habits, parental smoking, problems breathing, parental profession and also on psychological issues. sleep habits will also be answered in this questionnaire, and parents will also answer the strengths and difficulties questionnaire. the children over 6 years old will respond a child stress scale and the child of stressing sources in child; children less than 6 years will have the questionnaire responded by parents. the children will undergo a clinical examination to assess dental wear, according to the bewe (basic erosive wear examination index). the study evaluations consist of baseline, 1, 7, 15 and 30 days.


Eligibility criteria:
inclusion criteria: * children with probable sleep bruxism exclusion criteria: * systemic diseases; * medical and/or behavioral conditions that requires special considerations regarding management/treatment of the child.
herpes zoster: risk factors, complications and special situations

Conditions: Herpes Zoster

Summary: this retrospective analysis is to investigate patients' history and clinical presentation in herpes zoster (hz), zoster-related complications, post-zoster neuralgia and herpes zoster management in order to improve the management of hz patients, to refine hz-vaccination strategies and elucidate cost factors of hz in in the setting of a university hospital in switzerland generally and in a dermatology department specifically.


Eligibility criteria:
inclusion criteria: * reports of patients with hz at university hospital basel between 2004-2018 exclusion criteria: * rejection to use patient data

Keywords: post-zoster neuralgia herpes zoster-related complications
sensitivity to intravenous nicotine: genetic moderators

Conditions: Nicotine Dependence

Summary: to determine if the mu opioid receptor gene (oprm1) a118g polymorphism moderates the subjective-rewarding effects of intravenous (iv) nicotine in male and female smokers. the subjective effects of nicotine will be measured with a drug effects questionnaire, including the ratings of "good effects" and "drug liking". we hypothesize that smokers with the ag/gg genotype for the oprm1 a118g will have attenuated subjective-rewarding effects from iv nicotine when compared to those with aa genotype.

increasing evidence suggest that mor contribute to nicotine's rewarding effect. further, the functional oprm1 a118g variant has been linked to rewarding effects of alcohol in alcohol users and to nicotine in female smokers. since no previous studies examined the influence of the a118g variation on pure nicotine responses, the next logical step is to evaluate how this genetic polymorphism affects nicotine's rewarding, cognitive, and physiological effects using iv nicotine administration in male and female smokers. in addition, the association of the g398a polymorphism of the chrna5 gene (rs16969968) with maximal response to nicotinic agonists justifies examination of this snp as a moderator of iv nicotine sensitivity in humans (bierut et al. 2008). this snp will be examined in an exploratory fashion since it is not feasible to fully stratify the study sample for multiple snps. the frequency of rs16969968 snp ranges from 35%-42% among those of european ancestry, making it feasible to examine this variation in our subject sample. currently this study is active and enrollment is continuing. currently there are 205 completers and on going.(june 2014)

Eligibility criteria:
inclusion criteria: * female and male smokers, aged 18 to 50 years; * history of smoking daily for the past 12 months, 10-25 cigarettes daily; * not seeking treatment at the time of the study for nicotine dependence; * have a ftnd score of at least 5 and co level \> 10ppm; * in good health as verified by medical history, screening examination, and screening laboratory tests; * for women, not pregnant as determined by pregnancy screening, nor breast feeding, and using acceptable birth control methods. exclusion criteria: * history of major medical illnesses that the physician investigator deems as contraindicated for the patient to be in the study; * regular use of psychotropic medication (antidepressants, antipsychotics, or anxiolytics) and recent psychiatric diagnosis and treatment for axis i disorders including major depression, bipolar affective disorder, schizophrenia or panic disorder; * abuse of alcohol or any other recreational or prescription drugs.

Keywords: smoking, nicotine, cigarettes
metoclopramide for gastric visualization in active upper gi bleeding

Conditions: Upper GI Bleeding

Summary: this study aim to evaluate the efficacy of metoclopramide for gastric visualization in patients with active ugib. this is a double-blinded, multicenter rct. patients with 'active' ugib (hematemesis or presence of fresh blood in the nasogastric tube) were enrolled. the eligible patients were randomly assigned in a concealed 1:1 allocation to received either intravenous metoclopramide or placebo before endoscopy. the primary outcome was 'adequate visualization' by objective endoscopic visualized scores(evs). secondary outcomes included mean difference in total evs and evs at each location , duration of egd, immediate hemostasis, need for a second look egd, units of blood transfusion, length of hospital stay and 30-day rebleeding rate.

* this is double-blinded, multicenter rct including six hospitals in thailand. * the participated endoscopists had work experience for endoscopy more than three years. * all endoscopists at six participating sites attended the pre-study meeting for standardization of the protocol and scoring system. * the primary outcome was 'adequate visualization' by objective endoscopic visualized scores(evs). ; to assess overall endoscopic visualization, we estimated the coverage of a blood clot on mucosa in four locations including 1) gastric fundus, 2) corpus, 3) antrum and 4) duodenal bulb, according to the reference endoscopic views in protocal. * all photos, including the reference endoscopic views, were taken and internally validated by another endoscopist who was blinded to the randomization allocation. * this study includes pre-specified subgroup analysis by location of bleeding including gastric subgroup analysis.

Eligibility criteria:
inclusion criteria: * all adult patients (aged ≥ 18years) * active ugib who arrived at emergency room (er) and had a schedule for egd within 12 hours after onset of bleeding ; active ugib was defined as having hematemesis or fresh blood by diagnostic gastric lavage at the er. exclusion criteria: * known allergy to metoclopramide * prior gastric or duodenal surgery * known case of esophageal, gastric or duodenal cancer; * advanced hiv infection (defined as who criteria13-15: cd4 \<200 cell/mm3 or who clinical stage 3 or 4) * pregnancy * gastric lavage was performed with solution \> 50 ml.

Keywords: active upper gi bleeding egd gastric visualization metoclopramide
early incidence of occupational asthma among bakers, pastry-makers and hairdressers

Conditions: Occupational Asthma

Summary: background: occupational exposures are thought to be responsible for 10-15% of new-onset asthma cases in adults, with disparities across sectors. because most of the data are derived from registries and cross-sectional studies, little is known about incidence of occupational asthma (oa) during the first years after inception of exposure. this study focuses on this early asthma onset period among young workers in the bakery, pastry making and hairdressing sectors in order to assess early incidence of oa in these "at risk" occupations according to exposure duration, and to identify risk factors of oa. methods: this study is a longitudinal retrospective study with a nested case-control to identify risk factors of oa. the assessment of incidence evolution is made by exploring a series of promotions (or retrospective cohorts) with increasing duration since at work. the study population is composed of subjects who graduated between 2001 and 2006 in sectors where they experience exposure to organic or inorganic allergenic or irritant compounds (with an objective of 150 subjects by year) and 250 young workers with no specific occupational exposure. this study is a descriptive, monocentric, longitudinal and retrospective study with cross-sectional measurements.


Eligibility criteria:
inclusion criteria: * for the exposed group: to be graduated between 2001 and 2006 from nine vocational schools in lorraine, north-eastern france * for the "non-exposed" group: to be graduated in 2001 in the sale or the food sectors (butcher, pork butcher, caterer, cook job,...) from the same vocational schools exclusion criteria: * asthma diagnosed before apprenticeship * for the "non-exposed" group: to have worked previously or later in a sector at risk with oa

Keywords: incidence young workers occupations at risk public health epidemiology polymorphisms gentic
evaluation of pain trajectories after surgery and their potential relationship with chronicity at 3 months

Conditions: Surgical Procedures, Operative; Pain; Chronic Pain

Summary: the effective management of acute postoperative pain remains a daily challenge despite the organizational efforts made and the techniques put in place. thirty percent of patients who undergo surgery suffer from chronic post-surgical pain, of which 5 to 10% are of severe intensity. many preoperative, intraoperative, and postoperative factors, related to the patient, the surgical procedure, or the anesthetic technique, have been incriminated as risk factors for chronic post-surgical pain. the severity of acute postoperative pain is recognized as one of the risk factors for the occurrence of chronic post-surgical pain on which we can hope to interact during the peri-operative period. in this cohort study, we wish to define the typologies of postoperative pain trajectories observed from day 0 to day 7 and to estimate the proportion of patients with an abnormal resolution of pain in a model of organization such as that of our institution, in classic hospitalization and in ambulatory care.


Eligibility criteria:
inclusion criteria: * the patient must be insured or beneficiary of a health insurance plan * the patient is available for 3 months of follow-up * the patient has undergone a planned surgical procedure in one of the participating departments * the patient is willing and able to respond to the study questionnaires exclusion criteria: * the patient is participating in another study * the patient is in an exclusion period determined by a previous study * the patient is under judicial protection, under tutorship or curatorship * it is impossible to correctly inform the patient * patient admitted to the icu and still intubated at day 1

Keywords: pain trajectory