Kornimate/medical-research-clean huggingface dataset:
minneapolis children's blood pressure study

Conditions: Cardiovascular Diseases; Heart Diseases; Hypertension; Obesity

Summary: to examine environmental and familial correlates of childhood blood pressure in order to predict elevated blood pressure in young adulthood. also, to investigate the phenomena of tracking of blood pressure and obesity from childhood to young adulthood.

background: hypertension has been clearly identified as a major risk factor for coronary heart disease and stroke. hypertension screening and intervention programs for children are based on the concept that high normal blood pressure may be the childhood antecedent of adult hypertension or that blood pressure 'tracks' through childhood, adolescence, and adulthood. blood pressure tracking has been well established for adults and young adults but results from various studies in children are controversial. at a symposium on high blood pressure in the young in 1979, it was concluded that there was insufficient information to recommend specific interventions for prepubertal children with blood pressure levels in the upper percentiles of the blood pressure distribution. studies of longer duration with large population sizes and repeated blood pressure measurements over time were required to determine if blood pressure levels at these young ages were predictive of adult hypertension. design narrative: in the spring of 1978 a total of 10,423 children, ages 6-8 were screened. a subsample was invited to join the study of blood pressure measurement. the sample was selected as follows: all children in the top five percent of the initial systolic blood pressure distribution; all children in the bottom five percent of the initial systolic blood pressure distribution; a random sample of one in two of the remaining black children; a random sample of one in nine of the remaining white children; and all the remaining children of other races. included were families of about 200 native american children. of 2,641 selected children, 878 refused leaving a sample of 1,753. baseline data on age, race, sex, triceps skinfold thickness, dietary history, urinary sodium and potassium excretion, physiological measures, life event changes, medical history, demographic data and body size measurements of children and their parents were collected at the first home interview conducted between 1978 and 1979. the children were followed twice per year in 1978 to 1980 and 1982 to 1985 for blood pressure and body size. annual measurements were made of blood pressure, height, weight, skinfold thickness, and body girths. screenings continued through early 1991 when the cohort was 19-21 years of age. several substudies were conducted including the relationship of red blood cell cation transport to essential hypertension, type a behavior assessments, and familial aggregation of coronary-prone behavior. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria
a study to evaluate the safety and effectiveness of the left atrial appendage closure therapy using bsj003w

Conditions: Atrial Fibrillation Non-Rheumatic

Summary: the purpose of this study is to confirm the safety and effectiveness of the bsj003w in japanese patients with non-valvular atrial fibrillation at increased risk of thromboembolism in japanese clinical environment


Eligibility criteria:
inclusion criteria: 1. the subject is japanese, over 20 years old and provides written informed consent to participate in the trial 2. the subject has documented paroxysmal, persistent or permanent non-valvular atrial fibrillation 3. the subject has a calculated cha2ds2-vasc score of 2 or greater and is recommended for long-term oral anti-coagulation therapy 4. the subject is deemed by their physicians to be suitable for anticoagulant therapy and have an appropriate rationale to seek a non-pharmacologic alternative to warfarin 5. the subject is eligible to come off warfarin therapy if the laa (left atrial appendage) is sealed (i.e. the subject has no other conditions that would require warfarin therapy). exclusion criteria: 1. the subject has a prior stroke (ischemic or hemorrhagic) or transient ischemic attack within the 90 days prior to consent 2. the subject has had a myocardial infarction either non-st elevation or st elevation myocardial infarction within 90 days prior to consent with or without intervention 3. the subject had or is planning to have any cardiac (e.g. cardioversion, coronary angiogram, percutaneous coronary intervention, cardiac ablation, etc.) or non-cardiac invasive or surgical procedure (e.g. cataract surgery, endoscopy, etc.) within 30 days prior or 45 days after the bsj003w implant 4. the subject has a history of atrial septal repair or has an atrial septal defect/persistent foramen ovale device 5. the subject has an implanted mechanical valve prosthesis in any position 6. the subject currently new york heart association class iv congestive heart failure 7. the subject is contraindicated to aspirin 8. the subject is contraindicated or seriously allergic to thienopyridine 9. the subject is of childbearing potential and is, or plans to become pregnant during the time of the study 10. the subject is not able and willing to return for required follow-up visits and examinations 11. subjects who are currently enrolled in another investigational study (of which primary endpoint follow-up have not been completed yet). 12. the subject has other reason not to be eligible for this study per investigators' discretion.
glycemic evaluation of novel staple foods

Conditions: Diabete Type 2; Diabetes Mellitus

Summary: in this study, the combined effects of functional foods (i.e. anthocyanin fortified bread, microfluidic co-flow noodles, 5ibreplus™-fortified white rice) is investigated in an ad-libitum diet and their contributions to diabetes management.

research has confirmed that a food's glycemic effect cannot be accurately predicted from the type and amount of carbohydrates it contains, as the rate at which the carbohydrates is digested and released into the bloodstream is influenced by many factors such as the food's physical form, its fat, protein and fibre content, and the chemical structure of its carbohydrates. for these reasons, it is possible to produce food from the same group with different effects on blood glucose. consumption of low gi food has shown to improve glycemic control, lipid profile and reduce systemic inflammation. with bread, noodles and rice being the staple food for many singaporeans, functional staple food alternatives offer a lower gi alternative without greatly affecting the population's dietary preference. preliminary studies for each functional staple food alternative (for bread, noodles, and rice) had reflected improved glycaemic responses compared to their staple counterparts.

Eligibility criteria:
inclusion criteria: * chinese ethnicity * english-speaking * age between 21 - 70 years old inclusive. * confirmed type 2 diabetes with hba1c level of less than 10% * not on prandial insulin therapy * subjects with stable medical problems not limited to hypertension and hyperlipidemia exclusion criteria: * current smoker or use of tobacco products within the 3 months * vegetarian or other dietary restrictions that would not allow the subject to consume the test meal. * persons with electronic medical implants (e.g. pacemaker). * persons with known or ongoing psychiatric disorders or drug abuse within 3 years. * women who are pregnant or lactating. * persons with an average weekly alcohol intake that exceeds 21 units per week (males) and 14 units per week (females). 1 unit is equivalent to: * 12 oz or 360 ml of beer; * 5 oz or 150 ml of wine; * 1.5 oz or 45 ml of distilled spirits. * persons with active infection(s) requiring systemic, antiviral or antimicrobial therapy that will not be completed prior to the first study visit * persons who have undergone treatment with any investigational drug or biological agent within one (1) month of screening or plans to enroll in another study involving investigational drugs/biological agents during the duration of this study. * persons with significant change in weight (+/- 5%) during the past month. * persons with a known allergy to rice bran, dietary fiber, alginate and other study components (anthocyanins, soy protein).
depth of sedation and its impact on cerebrovascular reactivity in acute respiratory distress syndrome: a pilot analysis

Conditions: ARDS, Human

Summary: investigation of the feasibility of monitoring processed transcutaneous electroencephalography (eeg), a method of interpreting brain activity, and near-infrared spectroscopy (nirs), a method of determining levels of tissue oxygenation (sto2) in the brain, for patients with acute respiratory distress syndrome (ards) in the icu.

the aim of this study is to determine the feasibility of using masimo sedline processed eeg monitoring and masimo o3 nirs to monitor optimal depth of sedation for patients with ards in the icu. to achieve this, non-invasive devices will be applied to the participant to measure processed eeg signal and sto2. cerebrovascular reactivity will be determined using the following two values: 1. sedopt: the optimal depth of sedation that minimizes correlation between sto2 and processed eeg monitoring. 2. mapopt: the optimal blood pressure that minimizes correlation between sto2 and map. demographic information (age, sex, height, weight), past medical history, etiology of ards, disease severity, routine bloodwork, and dose of sedation will also be documented.

Eligibility criteria:
inclusion criteria: * adult patient admitted to the icu * ards confirmed according to the berlin definition * invasive mechanical ventilation * deep sedation and/or neuromuscular blockade required for ards treatment at the discretion of the treating medical team * application of monitoring devices feasible exclusion criteria: * more than 24 hours elapsed since icu admission * death is deemed imminent and inevitable during the next 24 hours * known allergy to a textile component of the device * consent declined from patient or authorized third party * the treating clinician believes that participation in the study would not be in the best interest of the patient

Keywords: near-infrared spectroscopy depth of sedation intensive care unit electroencephalography acute respiratory distress syndrome
comparison of textbook outcomes between laparoscopic and open total gastrectomy for gastric cancer

Conditions: Gastrectomy; Gastric Cancer

Summary: gastric cancer patients underwent total gastrectomy with curative intent between in a single center were included in this retrospective study. patients divided to two groups as open and laparoscopic groups and compared in terms of demographic data, tumor characteristics, operative data and textbook outcome

gastric cancer patients underwent total gastrectomy with curative intent between july 2018 and january 2024 in a single center were included in this retrospective observational study. enrolled patients divided to two groups as open total gastrectomy (open group) and laparoscopic total gastrectomy (lap group). data of patients obtained via the hospital software system. demographic data, body mass index(bmi), charlson comorbidity index (cci) score and baseline characteristics, operative and postoperative results, tumor characteristics and textbook outcome results were investigated. postoperative complications were pancreatic fistula, pleural effusion, pneumonia, anastomotic leak, intraabdominal abscess, surgical site infection, postoperative ileus. all patients were already curative surgery patients and underwent total gastrectomy and d2 lymphadenectomy. apart from this, the list of criteria for a patient who had a textbook outcome was as follows: no intraoperative complication, achievement of tumor-negative margins, including ≥15 harvested lymph nodes in resected specimen, no severe postoperative complication(clavien-dindo score≥3, (cd)), no reintervention, no readmission to intensive care unit after once coming to the surgical ward, no prolonged hospital stay (≤21 days), no postoperative mortality (30 days) and no readmission after discharge from the hospital

Eligibility criteria:
inclusion criteria: * gastric cancer patients underwent total gastrectomy with curative intent exclusion criteria: * emergency surgery, * recurrent disease * metastatic disease, * conversion to open surgery, * robotic gastrectomy.

Keywords: total gastrectomy textbook outcome open gastrectomy minimally invasive surgery
study of the pathogenesis of olfactory disorders in covid-19

Conditions: Coronavirus Infection; Severe Acute Respiratory Syndrome; Sars-CoV2

Summary: this study is a case-control study to characterize the molecular and cellular anomalies of the olfactory epithelium of covid-19 patients with isolated anosmia, by comparison with the olfactory epithelium of non-infected subjects.

olfactory and taste dysfunctions are common and early onset in covid-19, especially in pauci symptomatic patients, and may be the main clinical manifestations of the infection. olfactory dysfunction could result from infection of the olfactory system by sars-cov-2 or from inflammation induced by the virus. while the recent development of covid-19 pulmonary lesion research has revealed a viral, inflammatory and vascular origin, factors that cause olfactory disorders in covid-19 are just beginning. acute anosmia observed in some patients with covid-19 could result from: * the direct infection of olfactory sensory neurons or neural stem cells of the olfactory mucosa, * an underlying inflammation of the olfactory mucosa, leading to possible neurodegeneration of olfactory sensory neurons, and neural stem cells of the olfactory mucosa, by analogy with the respiratory viruses responsible for chronic rhinosinusitis. it is therefore necessary to conduct a virological, cellular, immunological and inflammatory study of the olfactory epithelium from covid-19 patients with isolated anosmia to identify the origin of these olfactory disorders. this study is a case-control study to characterize the molecular and cellular anomalies of the olfactory epithelium of covid-19 patients with isolated anosmia, by comparison with the olfactory epithelium of non-infected subjects. following measures will be performed at inclusion : * taste and olfactory function evaluation by a self-questionnaire taste and smell survey (tts) and a visual analogue scale (vas) * nasal swab sampling for collection of epithelium cells and olfactory mucus.

Eligibility criteria:
inclusion criteria: covid-19 patients * age \> 18 years * subject consulting in the context of the covid-19 screening care for a suspected sars-cov-2 infection controls * age \> 18 years * subject consulting in the ear, nose and throat department with no biologically confirmed covid-19 or suspected covid-19 in the past 8 weeks, and no symptoms suggestive of covid-19 or another respiratory disease and therefore no recent anosmia or ageusia exclusion criteria (both covid-19 patients and controls): * refusal or contraindication to nasal swab * presence of nasal sinus pathology

Keywords: sars-cov-2 sense of smell disorders anosmia olfaction nasal neuroepithelium olfactory mucosa
self-administered lidocaine gel for pain-control during cervical preparation for dilation and evacuation

Conditions: Pain Management, Cervical Preparation

Summary: this study seeks to compare self-administered lidocaine gel for pain control during cervical preparation for dilation and evacuation (d\&e) to paracervical block.


Eligibility criteria:
inclusion criteria: * women 18 and older * intrauterine pregnancy ≥16 weeks gestation * english speaking competency * willing and able to sign consent forms * agree to comply with study procedures exclusion criteria: * women less than 18 years of age * iv conscious sedation * known allergy to study medication (lidocaine) * any women not meeting inclusion criteria above will be excluded from participation
assess intraoperative pain for restorative treatment of maxillary 1st permanent molars using artinibsa versus artpharma in children during infiltration technique

Conditions: Pain

Summary: the aim of this study is to assess intraoperative pain for restorative treatment of maxillary first permanent molars using artinibsa versus artpharma in children during infiltration technique.

local anesthesia is very important during dental procedure because it's a temporary loss of sensation which will lead to decrease the pain. local anesthesia started with discovery of cocaine in 1860. followed by developments of novocaine 1904 and lignocaine in 1942 by lofgren. it became the gold standard drug compared to other local anesthetic. later, several new drugs were discovered such as:bupivacaine, articaine, mepivicaine etc. articaine hydrochloride (hcl) was available in germany since 1976. it's the only amide local anesthesia containing ester group in its molecular structure leading to metabolizing of the drug by both plasma esterases and liver microsomal enzymes, the clinical efficacy and advantages of articaine is the duration of its anesthetic effect and its superior diffusion through the bony tissue.

Eligibility criteria:
inclusion criteria: * children aged 8-10 years old * mentally capable of communication * cooperative children need restorative treatment exclusion criteria: * medically compromised patient * primary teeth requiring pulpotomy or pulpectomy * parent or guardians who refuse participating in the study

Keywords: articaine infiltration technique restoration primary teeth intraoperative pain
a study of management of tarceva - induced rash in patients with non-small cell lung cancer.

Conditions: Non-Small Cell Lung Cancer

Summary: this 2 arm study will evaluate the management of tarceva-induced skin rash in patients with non-small cell lung cancer who have failed first-line chemotherapy for advanced disease. eligible patients will be randomized to receive a)doxycycline 100mg po daily or b)no preventative treatment; all patients will receive tarceva 150mg/kg po daily. the anticipated time on study treatment is until disease progression or intolerable toxicity, and the target sample size is 100-500 individuals.


Eligibility criteria:
inclusion criteria: * adult patients, 18-75 years of age; * confirmed non-small cell lung cancer; * failure after first line chemotherapy for advanced disease, and scheduled for second line therapy with tarceva. exclusion criteria: * rash of any etiology at study entry; * history of significant heart disease; * any other malignancies (other than adequately treated squamous cell skin cancer, or in situ cancer of the cervix); * history of allergic reactions to tetracyclines.
eus-guided laser ablation in pancreatic adenocarcinoma

Conditions: Pancreatic Adenocarcinoma; Pancreas Cancer

Summary: this study evaluates the possibility of performing local therapy for pdac using laser ablation of the tumor under ultrasonography (eus) guidance. safety of the procedure as well as post procedural quality of life will be also evaluated.

pancreatic adenocarcinoma (pdac) is projected to be the second cause of cancer death in western societies within a decade. management include chemotherapy and/or radiation therapy, while resectable disease is possible only in 15% of cases. despite these therapeutic approaches, the survival rate of unresectable pancreatic cancer remains disappointing. recently, there is a growing interest in the development of alternative therapeutic approaches, which can work in parallel with standard chemoradiation therapy. these methods include intra-lesion injection/instillation of antitumoral agents performed through a laparoscopic approach, or percutaneously or under endoscopic ultrasound (eus) guidance and tumor volume reduction procedures using ablative techniques. in this context laser ablation has been reported to be effective in inducing coagulative necrosis of the tumour in absence of major adverse events. however, the available studies on the matter are limited by small sample size, lack of extended follow up and informations about the possibility to ablate the entire tumour mass.

Eligibility criteria:
inclusion criteria: * histological diagnosis of pancreatic ductal adenocarcinoma * unresectable advanced, non-metastatic stage iii tumor * stable disease without regression or progression after 6 months of chemotherapeutic treatment * locally progressive disease after chemiotherapy, without evidence of metastases * age \>18 and \<80 years * willing to be followed up c/o the fondazione policlinico a. gemelli university hospital * signed informed consent exclusion criteria: * stage i, stage ii, stage iv disease * absolute contraindications to general anesthesia or deep sedation * absolute contraindications to perform digestive endoscopy * known bleeding disorder that cannot be sufficiently corrected with co-fact or fresh frozen plasma (ffp) * use of anticoagulants that cannot be discontinued * international normalized ratio (inr) \>1.5 or platelet count \<50.000 * pregnancy or lactation * unable to sigh informed consent
brain imaging of pain-related processing and structural properties in disc degenerative disease

Conditions: Degenerative Disc Disease

Summary: in this study, we apply brain mr imaging techniques at 3 tesla to assess pain-relevant processing in patients with disc degenerative disease (ddd) scheduled for back surgery and age- and gender-matched controls without back pain. data collection pre-surgery is performed over two days: on the first day, all participants undergo a battery of questionnaires relevant for individuals with chronic pain and pain sensitivity testing, including temporal summation and pressure pain thresholds. on the second day, participants undergo a mri protocol, which includes functional mri (fmri) and diffusion tensor imaging to assess microstructural properties and structural connectivity. during fmri, an experimental pressure pain paradigm is performed at the calf i.e. a location not connected to patients' chronic pain condition. instead, the experimental pain paradigm serves as a condition to test processing of noxious stimulation unrelated to patients' experienced chronic pain. the noxious input pressure is individually calibrated to 50 on a 0-100 vas scale to ensure that individual pain perceptions, despite different pressure intensities, are comparable across participants. the sensory stimulation will consist of a low standardized pressure intensity (150kpa). in an additional fmri paradigm, participants do not receive stimulation but are instructed to continuously rate fluctuating spontaneous ongoing back pain (ddd) or perceived unpleasantness (controls). this project aims at investigating measures of brain architecture, neural response connected with evoked pain, connectivity (structural and functional) and pain-relevant psychometrics and questionnaire data in disc degenerative disease patients scheduled for back surgery. specifically, mri is performed to test whether i) patients display differences in properties of the mesolimbic circuit compared to healthy individuals and ii) behavioural as well as clinical characteristics related to the acquired mri markers. this study is intended to serve as a baseline in a longitudinal project testing associations with between findings at baseline and following surgery (fusion/disc implants).


Eligibility criteria:
inclusion criteria:inclusion criteria: * 30-60 year * right-handed * ddd patients: radiologically verified ddd and ddd pain as their main pain complaint exclusion criteria: * previous spine surgery * significant pain problems due to other causes and/or other chronic pain syndromes * inflammatory rheumatic diseases * neurological/psychiatric disorders * severe cardiovascular disease * substance abuse * bmi\>40 * contraindication to mri