Kornimate/medical-research-clean huggingface dataset:
genetic and neural predictors of adolescent depression

Conditions: Major Depressive Disorder

Summary: this study aims to examine the relationship between mood and brain activity in adolescent girls in order to better understand the genetic and neural predictors of adolescent depression. the participants in this study will be healthy female adolescents aged 12-14 and their mothers. they will participate for a total of six months. adolescent participants will have three study sessions at mclean hospital, and during two of them, their mothers will also have assessments. adolescent assessments will include interviews, questionnaires, computer tasks, and collection of a saliva sample for genetic analyses. their second study visit will include an fmri scan. parent assessments will include an interview, questionnaires, and a computer task.


Eligibility criteria:
adult cohort a. mdd mothers cohort inclusion criteria: * current or past major depressive disorder * english as first language or english fluency * biological daughter who meets inclusion/exclusion criteria for high risk female adolescent b. healthy control mothers cohort inclusion criteria: * no history of psychopathology * english as first language or english fluency * biological daughter who meets inclusion/exclusion criteria for healthy female adolescent adolescent cohort general inclusion criteria for adolescent cohorts: * female * ages 12-14 * english as first language or english fluency * right handed general exclusion criteria for adolescent cohorts: * past or present diagnosis of major depressive disorder * past or present diagnosis of any anxiety disorder * past or present diagnosis of bipolar disorder * past or present diagnosis of adhd * presence of medical or neurological illness (head injury, loss of consciousness greater than 5 minutes, seizure) * current use of psychotropic medication * presence of any contraindication for mri: * cardiac pacemakers * metal clips on blood vessels (also called stents) * artificial heart valve, artificial arms, hands, legs, etc. * brain stimulator devices * implanted drug pumps * ear or eye implants * known metal fragments in eyes * exposure to metal filings or shrapnel (sheet metal workers, welders, and others) * other metallic surgical hardware in vital area * certain tattoos with metallic ink * certain iuds containing metal * certain transdermal (skin) patches such as: * nicoderm (nicotine for tobacco dependence) * transderm scop (scopolamine for motion sickness) * ortho evra (birth control) * positive urine pregnancy test c. high risk female adolescent additional inclusion criterion: • biological daughter of participant in the mdd mothers cohort d. healthy female adolescent additional inclusion criterion: • biological daughter of participant in the healthy control mothers cohort

Keywords: major depressive disorder mdd depression adolescent
multislice spiral computed tomography and cardiomyopathy

Conditions: Cardiomyopathies

Summary: conventional coronary angiography is the recommended procedure in detection of coronary stenosis in patients with idiopathic cardiomyopathy. the aim of this prospective study is to assess diagnostic accuracy of multislice spiral computed tomography coronary angiography in patients with idiopathic cardiomyopathy in sinus rhythm, compared to conventional coronary angiography.

the principal aim of this study is to assess the diagnostic accuracy (sensitivity, specificity, predictive values) of multislice spiral computed tomography (msct) coronary angiography among patients having idiopathic hypokinetic dilated cardiomyopathy in sinus rhythm, compared to conventional coronary angiography. the secondary aims are to assess the performance of msct in coronary sinus anatomy assessment, and in quantitative measurement of left ventricular anatomical criteria (telediastolic diameter, septal and posterior wall thickness, and ejection fraction) compared to echocardiography. lastly, renal tolerance of msct will be studied. this prospective monocentric study will include 120 patients scheduled to undergo coronary angiography for etiologic diagnosis of idiopathic cardiomyopathy (defined by a left ventricle echographic ejection fraction ≤ 40 %, without anamnestic or electrocardiographic arguments in favour of coronary artery disease) in sinus rhythm. msct will be performed within 3 months after conventional coronary angiography, with blinded analysis.

Eligibility criteria:
inclusion criteria: * patients scheduled to undergo coronary angiography, * etiologic diagnosis of idiopathic cardiomyopathy (defined by a left ventricle echographic ejection fraction ≤ 40 %, without anamnestic or electrocardiographic arguments in favour of coronary artery disease), * in sinus rhythm, * informed written consent. exclusion criteria: * allergy to iodine, * history of coronary artery bypass graft, * history of percutaneous coronary angioplasty, * history of myocardial infarction, * known coronary artery disease, * q waves on the ecg, * unstable haemodynamic status, * urgent revascularisation or urgent valvular surgery, * heart rate \> 80 bpm (before msct), * pregnancy, * enrollment in another study. * severe renal or respiratory insufficiency.

Keywords: msct idiopathic cardiomyopathy sinus rhythm
multicenter epidemiologic study of severe community acquired pneumonia in china

Conditions: Community-acquired Pneumonia

Summary: this study is aimed to understand the clinical characteristics, etiology and resistance phenotype of major pathogens of scap in china through multicenter and prospective investigation. thus to provide epidemiological basis for improving the scap diagnosis and treatment protocol suitable for china.

during the study period, all patients who are diagnosed with scap and meet the inclusion criteria in the participating unit should be enrolled in the study . at the end of the trial, each participating unit should complete at least 20 qualified cases, and all participating units should have a total of more than 300 qualified cases. 1. learn about the etiology of scap in china. 2. grasp the resistance phenotype and molecular epidemiology of major pathogens of scap in china. 3. know the important clinical characteristics of scap in china, including age, basic diseases, length of hospital stay, length of stay in icu, duration of mechanical ventilation, clinical manifestations, imaging findings, complications, mortality, etc. 4. analyze and clarify the clinical risk factors of affecting scap mortality. 5. understand the current situation of antibiotic treatment of scap in china.

Eligibility criteria:
inclusion criteria: * age \>18 yeas; * diagnosis of cap according to the diagnosis and treatment of community-acquired pneumonia in adults: 2016 clinical practice guidelines by the chinese thoracic society, chinese medical association. exclusion criteria: * bronchiectasis; * active tuberculosis; * aspiration pneumonia or obstructive pneumonia; * hospitalized in 2 weeks; * hospitalized or ventilated ≥5 days; * severe immunosuppression patients; * irregular follow-up and lost follow-up; * withdraw from the study for any reason.

Keywords: community acquired pneumonia epidemiology multicenter study
left atrial strain and supraventricular arrhythmia burden in cardiac light chain amyloidosis following chemotherapy

Conditions: Supraventricular Arrhythmia; Left Atrial Abnormality; Amyloid Cardiomyopathy; Congestive Heart Failure

Summary: the purpose of this study to assess the longitudinal changes in left atrial strain and supraventricular arrhythmia burden after chemotherapeutic strategies in cardiac light chain amyloidosis.

light chain (al) amyloidosis is a disease characterized by localized or systemic accumulation of amyloid fibrils in tissues caused by abnormal folding of light chain immunoglobulins and affecting organ functions. due to the accumulation of abnormal folding immunoglobulins in the cardiac conduction system, arrhythmia susceptibility has been reported to increase significantly. atrioventricular blocks and supraventricular arrhythmia are mainly detected among the most common arrhythmia. while these developing supraventricular arrhythmias and atrioventricular blocks in non-amyloidosis diseases result in increased mortality and morbidity, there is insufficient data on cardiac al amyloidosis treated with chemotherapy. for this reason, this study was planned, and the purpose of this study is to assess the longitudinal changes in left atrial strain and supraventricular arrhythmia burden after chemotherapeutic strategies in cardiac light chain amyloidosis. after being informed about the study, it is planned to recruit and follow up al-amyloidosis patients with cardiac involvement who are currently receiving/planned chemotherapy followed by hematology or who are planned for bone marrow transplantation within one year after obtaining written consent from the patients.

Eligibility criteria:
inclusion criteria: * ≥18 years old * patients who give the informed consent * patients with cardiac primary light chain amyloidosis or due to multiple myeloma who are newly diagnosed, currently receiving chemotherapeutic treatment, or are scheduled for bone marrow transplantation exclusion criteria: * a history of myocardial infarction, coronary artery disease, percutaneous coronary intervention and revascularization * \< 18 years old * a history of severe aortic and mitral valve disease * patients who do not give the informed consent * a history of severe hypertension (sbp\>180 mmhg or dbp ≥110 mmhg or the need to use three or more antihypertensive agents) * stable coronary artery patients with ischemia data in stress tests (exertion test, myocardial perfusion scintigraphy) * presence of non-amyloidosis, systemic, inflammatory or autoimmune disease * patients whose cardiac imaging is not interpretable * patients whose ecg is not interpretable

Keywords: left atrial strain supraventricular arrhythmia heart failure cardiac amyloidosis amyloid cardiomyopathy arrhythmia strain imaging
comparison of the therapeutic effects of vr and hysteroscope + laparoscope in the treatment of cesarean scar diverticula

Conditions: Cesarean Scar Diverticula

Summary: cesarean scar diverticula (csd) is a novel recognized cause of postmenstrual abnormal uterine bleeding in women. no clinical guidelines have been issued for the management of csd. currently, several limited surgical management procedures for csd have been reported, such as hysteroscopic combined with laparoscopic excision (abbreviated as hysteroscope + laparoscope) and vaginal repair of csd (abbreviated as vr). however, which management can achieve better clinical effects remains unknown. therefore, this prospective study is designed to compare the therapeutic effects between vr and hysteroscope + laparoscope in the treatment of csd.


Eligibility criteria:
inclusion criteria: 1. patients are younger than 40. 2. clearly diagnosed with csd. 3. experiencing clinical features of abnormal uterine bleeding, prolonged menstrual flow (the duration of menstruation is more than 7 days). 4. the thickness of the remaining muscular layer of csd was less than 3 mm. 5. the women are at least 20 years old with singleton pregnancies and had undergone a cesarean delivery after at least 37 weeks of gestation. 6. the medicine conservative treatment is invalid. 7. refusing or use birth control pills contraindications. 8. no serious medical problems (important viscera function in the normal range). 9. no uterine fibroids, endometriosis, adenomyosis, and patients with ovarian cysts. 10. no gynaecology or other malignant tumors. 11. sign the informed consent. exclusion criteria: 1. over the age of 40; 2. indefinite diagnosis. 3. the absence of clinical manifestations of csd. 4. the presence of menstrual irregularities before cesarean delivery. 5. coagulation disorders. 6. malignant tumors. 7. with severe medical problems (severe liver disease, kidney disease, respiratory diseases, heart disease or uncontrolled diabetes, epilepsy, etc., dysfunction of important organs). 8. known chronic inflammatory diseases, any other uterine diseases (such as uterine fibroids, endometriosis and adenomyosis), uterine surgery except cesarean section. 9. use of intrauterine devices. 10. unwilling to comply with the research plan.

Keywords: cesarean scar diverticula
differential effects of a diet supplementation with plant sterol esters on human monocytes

Conditions: Hyperlipidemia

Summary: the purpose of this study is to evaluate the effects of a diet supplementation with plant sterol esters on serum lipids, plant sterol concentrations and monocyte subpopulations.

this study investigates effects of a diet supplementation with plant sterol esters on serum lipids, plant sterol concentrations and monocyte subpopulations.

Eligibility criteria:
inclusion criteria: * healthy individuals without known cardiovascular diseases exclusion criteria: * drugs that interfere with cholesterol metabolism * other use of dietary supplements * vegetarianism

Keywords: hyperlipidemia plant sterols monocytes
effectiveness of high protein diets in promoting weight loss in overweight and obese subjects.

Conditions: Overweight

Summary: several studies have reported greater weight loss when following high meat-protein diets but limited studies have studied high plant-based protein diets. thus we aim to investigate the effect of high protein diets in weight management and also to investigate the superior protein source in achieving this effect. in addition, we aim to develop dietary intervention strategies that are realistic and sustainable.

participants will be randomised to either high-protein diets (30% of energy) from animal or plant sources or standard protein diet (15% of energy) weight loss diet for 3 months.

Eligibility criteria:
inclusion criteria: * overweight or obese * age 18 and above * both males and females * live in illawarra area of australia exclusion criteria: * regular medication * smoker * food allergies * presence of disease which may alter metabolic rate

Keywords: calorimetry overweight weight loss appetite
sulforadex in healthy human males mad

Conditions: Prostate Cancer

Summary: to determine the safety and tolerability of multiple doses of sulforadex® in healthy male volunteers over 7 days with qd or bid dosing

this study will be conducted in a randomised, double-blind, placebo-controlled design with multiple ascending doses of sulforadex® administered qd \[once daily\] or bid \[twice daily\]) to healthy male subjects between 18 to 45 years of age.

Eligibility criteria:
inclusion criteria: 1. subject is a healthy male of any race aged 18 to 45 years, inclusive, at screening. 2. subject has a bmi of 18 - 25 kg/m2 inclusive at screening. 3. subjects must agree to use acceptable methods of contraception, 4. subjects should not donate sperm from the time of the first administration of treatment or study medication until 3 months following administration of the last treatment or dose of study medication. 5. subjects must be capable of understanding and complying with the requirements of the protocol and must have signed the icf prior to undergoing any study-related procedures. exclusion criteria: 1. all subjects must refrain from eating brassica vegetables or using brassica containing supplements for at least 7 days prior to the drug administration. brassica vegetables include cabbage, cauliflower, horseradish, landcress, ethiopian mustard, kale, collard greens, chinese broccoli, brussels sprouts, kohlrabi broccoli, broccoli flower, broccoli romanesco, wild broccoli, bok choy, komatsuna, mizuna, rapini, flowering cabbage, chinese cabbage, napa cabbage, turnip root, rutabaga, canola/rape seed, siberian kale, wrapped heart mustard cabbage, mustard seed (brown, black, white), tatsoi, rocket (arugula), garden cress, water cress, radish, daikon and wasabi. 2. subject has a clinically significant disease or any condition or disease that might affect drug absorption, distribution or excretion. 3. any clinically significant abnormal laboratory, vital signs or other safety findings as determined by medical history, physical examination or other evaluations conducted at screening or on admission. 4. ecg abnormalities in the standard 12-lead ecg (at screening) which in the opinion of the investigator is clinically relevant or will interfere with the ecg analysis. 5. history or current evidence of any clinically relevant cardiovascular, pulmonary, hepatic, renal, gastrointestinal, haematological, endocrinological, metabolic, neurological, psychiatric, or other disease. 6. positive results in any of the serology tests for hepatitis b surface antigen (hbsag), anti hepatitis core antibody (anti hbc ig g \[and anti hbc igm if igg is positive\], hepatitis c virus antibodies (anti hcv), and human immunodeficiency virus hiv 1 and 2 antibodies (anti hiv 1/2). 7. confirmed positive results from urine drug screen (amphetamines, benzodiazepines, cocaine, cannabinoids, opiates, barbiturates, tricyclic antidepressants and methadone) or from the alcohol breath test at screening and on admission (day -1). 8. history or clinical evidence of alcohol or drug abuse. 9. mentally handicapped.
immune/inflammatory biomarkers in postpartum depression

Conditions: Depression, Postpartum

Summary: this will be a very straightforward study assessing changes of immune/inflammatory peripheral biomarkers before/after delivery with postpartum mood and the psychopathological features of postpartum depression (ppd), and with mri measures of functional and structural brain integrity. multimodal assessment of peripheral cytokines, pbmc gene expression, facs immunophenotyping, and ido activation, will be validated with (a) clinical data about the presentation of ppd, (b) self- and observer ratings of psychopatology, (c) results coming from neuropsychological assessment of cognitive functions, and (d) multimodal brain imaging outcomes (wm integrity, functional connectivity, gm volumes). it is expected that worsening or stabilization of mood, and the diagnosis of ppd, will be paralleled by worsening or stabilization of these measures, thus providing new markers to estimate the susceptibility to the disorder, to identify targets for treatment, and to predict and monitor treatment efficacy.


Eligibility criteria:
inclusion criteria: -signed informed consent, able to understand, speak and write the national language exclusion criteria: * history of bipolar disorder, schizophrenia, schizoaffective disorder, psychosis nos; anorexia or bulimia nervosa; * taking following medications: antipsychotics, anticonvulsants, mood stabilizers, stimulants * active infection requiring antibiotics therapy; * immunosuppressed patient * other chronic diseases * signs of active infection requiring treatment * use of anti-inflammatory medication on a regular basis for a chronic inflammatory/autoimmune disorder. - - forbidden treatment: corticosteroids, nsad, immunosuppressant iv-ig based treatment * ongoing fever, infection treated by antibiotics or uncontrolled diabetes type i or ii; * existing cancer or history of cancer in the last 5 years (except skin epidermoid cancer or in-situ cervix cancer); * known hiv infection or clinically manifest acquired immune deficiency syndrome (aids), parkinson's or alzheimer's disease, or any other serious condition likely to interfere e with the conduct of the trial; * abuse of drugs or alcohol in the past 6 months * presence of chromosomal disorders
study on the value of non-invasive dual-pet information in subtype of metastatic breast cancer

Conditions: Breast Cancer

Summary: study on the value of non-invasive dual-pet(18f-fes pet and 68ga-her2-affibody pet) information in subtype of metastatic breast cancer

a phase ii, single-center study on the value of non-invasive dual-pet（18f-fes pet and 68ga-her2-affibody pet）information in subtype of metastatic breast cancer(mbc)

Eligibility criteria:
inclusion criteria: 1. subjects voluntarily joined the study, signed informed consent, and had good compliance. 2. female patients aged over 18 years (including cutoff value). 3. an eastern cooperative oncology group (ecog) performance status of 0 to 2. 4. recurrence or metastatic breast cancer confirmed by histopathology, or expect to be feasible metastasis puncture or surgery to confirm histopathological recurrence or metastatic breast cancer. exclusion criteria: 1. pregnancy or lactation. 2. alcohol allergy is not suitable for fes-pet/ c. 3. there are contraindications for patients who are expected to have metastasis puncture or surgery. 4. mental disorders or other conditions affecting patient compliance.
motor recovery with early imaging in stroke

Conditions: Stroke

Summary: this study will contribute to the field of stroke rehabilitation research by expanding the investigator's understanding of the neural mechanisms responsible for the development and expression of abnormal flexion synergy, a primary movement impairment due to stroke. the study will longitudinally evaluate motor tract morphology and motor impairment/function in an attempt to develop early neuroimaging-based predictors of the development of flexion synergy and its impact on reaching and hand recovery (6 month). the study will utilize quantitative motor testing (kinematics and kinetics) to measure motor impairment and reaching and hand function. both neuroimaging and quantitative motor testing will be conducted within 96 hours-, 2 weeks-, 3 months-, and 6 months-post stroke. the knowledge gained by this study will provide crucial structural and functional neuroimaging evidence that demonstrates the timeline of progressive ipsi- and contralesional motor pathway (including bulbospinal pathways) changes and the associated development of flexion synergy that grossly impacts reaching and hand function in individuals with moderate to severe stroke.


Eligibility criteria:
inclusion criteria: 1. stroke within the middle cerebral artery distribution based on brain mri done within 48 hours of admission 2. 18 to 85 years old 3. isolated motor deficits (hemiparesis) without significant aphasia, visual disturbances, or neglect based on the following scores on the nih stroke scale: 1a (level of consciousness) = 0- alert; keenly responsive. 1b (loc questions) = 0- asked month and age; answers both correctly. 1c (loc commands) = 0- asked to open/close eyes, grasp/release hand; performs both correctly. 2 (best gaze) = 0- horizontal eye movements; normal. 5 (motor arm) = 1, 2, 3, or 4- arm placed at 90 (sitting) or 45 (supine), drift, some effort, no effort against gravity, or no movement. 7 (limb ataxia) = 0- finger-nose-finger or heel-shin test; absent. 8 (sensory) = 0 or 1- pin prick; normal or mild-to-moderate sensory loss. 9 (best language) = 0 or 1- describe picture; no or mild-to-moderate aphasia. 11 (extinction and inattention) = 0 or 1- no abnormality or inattention to one modality. exclusion criteria: 1. premorbid disability or sensorimotor impairment 2. comorbidity medically contraindicating the administration of subsequent mri scanning and motor assessments 3. pain or hypersensitivity limiting motor assessment 4. limb edema limiting motor assessment