Kornimate/medical-research-clean huggingface dataset:
prediction of patient deterioration using machine learning

Conditions: Infection; Heart Failure; Chronic Obstructive Pulmonary Disease; Asthma; Gout Flare; Chronic Kidney Diseases; Hypertensive Urgency; Atrial Fibrillation Rapid; Anticoagulants; Increased

Summary: this is a retrospective observational study drawing on data from the brigham and women's home hospital database. sociodemographic and clinic data from a training cohort were used to train a machine learning algorithm to predict patient deterioration throughout a patient's admission. this algorithm was then validated in a validation cohort.


Eligibility criteria:
inclusion criteria: cared for in the brigham and women's home hospital study exclusion criteria: incomplete continuous monitoring data
immunotherapy with depigmented and polymerized allergen extract of olea europaea (gpit)

Conditions: Allergy; Rhinoconjunctivitis

Summary: the objective of this trial is to evaluate the clinical effectiveness of the administration of a depigmented and polymerized allergen extract of olea europaea in the rhinitis or allergic rhinoconjunctivitis

immunotherapy is a specific treatment for allergic diseases. unlike conventional pharmacological treatment, immunotherapy is the only treatment that could modify the natural course of allergic disease. this is a prospective double-blind placebo controlled study with two arms of treatment: placebo and active.

Eligibility criteria:
inclusion criteria: * positive suggestive clinical history of allergic seasonal rhinitis or rhinoconjunctivitis * patients of both gender \> 18 years old * positive prick test results using non modified olea europaea allergen extract (wheal size \> 3mm2) * specific ige to olea europaea * written informed consent exclusion criteria: * use of immunotherapy during the last four years. * any contraindication for the use of immunotherapy in accordance with european allergy and clinical immunology immunotherapy subcommittee criteria: * treatment with ß-blockers * coexistence of immunopathological diseases (e.g. of the liver, kidney, the nervous system, thyroid gland, rheumatic diseases) in which autoimmune mechanisms play a role * patients suffering from immune deficiencies * patients with serious psychiatric / psychological disturbances * in addition, the following was considered as exclusion criteria: * pregnant or/ in lactation patients * patients aspirin intolerance

Keywords: immunotherapy allergoid depigmented polymerized allergen-extract rhinoconjunctivitis
evaluation of the safety and efficacy of memantine as adjunctive treatment in schizophrenia patients

Conditions: Schizophrenia

Summary: standard antipsychotic drug regimens do not fully address the impact of cognitive symptoms associated with schizophrenia. the nmda receptor has been connected to the pathophysiology of schizophrenia. memantine is an uncompetitive nmda receptor antagonist. it is hypothesized that adjunctive therapy with memantine will reduce nmda receptor hyperactivity, improving signal to noise ratio and thereby improving cognitive symptoms.


Eligibility criteria:
inclusion criteria: * dsm-iv diagnosed schizophrenia or schizoaffective disorder who are on a stable antipsychotic regimen with brief psychiatric rating scale (bprs) total score greater than or equal to 26 and greater than or equal to 4 on at least one item exclusion criteria: * secondary diagnosis of bipolar i disorder * suicidal history * organic brain disease * dementia * history of substance abuse

Keywords: memantine adjunctive therapy schizophrenia
prospective multicenter registry of gender, diversity and inclusion (gedi) of women with acute coronary syndrome

Conditions: Acute Coronary Syndrome; Gender; Genetic Predisposition

Summary: create a multicenter prospective registry that collects information from women affected by acute coronary syndrome (acs). this registry aims to understand the diversity in the presentation of women with acs. it proposes to conduct a thorough characterization of the women involved in the study through genetic, biochemical, and molecular analysis.this approach aims to identify any differences in the characteristics of women with acs and to identify disease subtypes that may influence treatment options and clinical outcomes.

create a multicenter prospective registry that collects information from women affected by acute coronary syndrome (acs) from a wide range of cultural and ethnic backgrounds distributed across various italian regions. this registry aims to understand the diversity in the presentation of women with acs in italy, providing valuable data for a better understanding of the disease. additionally, it proposes to conduct a thorough characterization of the women involved in the study through genetic, biochemical, and molecular analysis. this analysis will be stratified by age and the etiology of coronary artery disease, distinguishing between obstructive and non-obstructive coronary artery disease. specific aims of this proposal are: 1. to create a multicenter prospective registry including women with acs from a variety of cultural and ethnical backgrounds in different italian regions 2. to deeply characterize women with acs through clinical, imaging, genetic, biochemical, and molecular phenotyping stratifying for age, etiology (obstructive vs non-obstructive cad) and diversity. 3. to assess socioeconomic status, health literacy and awareness of risk factors among enrolled patients.

Eligibility criteria:
inclusion criteria: * women \>/= 18 years with acs (stemi, nstemi or unstable angina). exclusion criteria: * age \< 18 years and/or unwillingness to sign informed consent and/or unwillingness to make follow-up visits

Keywords: acs gedi genetic dna mrna proteomic metabolomic
evidence-based laboratory test order sets in primary care

Conditions: Diabetes Mellitus; Hypertension; Cardiovascular Diseases; Fatigue; Anemia; Liver Diseases; Medication Monitoring; Gout; Chronic Kidney Diseases; Lung Embolism; Acute Coronary Syndrome; Diarrhea; Thyroid Diseases; Sexually Transmitted Diseases; Rheumatoid Arthritis; Obesity; General Check-up

Summary: cluster randomised controlled trial to evaluate what the effect is of evidence-based order sets aimed at five indications on the appropriateness of laboratory test ordering in primary care.

cluster randomised controlled trial in belgian primary care practices. participants will be primary care physicians working in primary care practices affiliated to one of three collaborating laboratories in the leuven, ghent or antwerp regions. primary care practices will be allocated and randomized to either the intervention or control group. physicians in pcps randomized to the intervention will be offered order sets based on indication when using the cpoe for ordering laboratory tests. the effect of order sets will be analyzed for 17 common indications for ordering laboratory tests in belgian primary care: diabetes mellitus, hypertension, cardiovascular disease, general check-up, unexplained fatigue, anemia, liver pathology, medication monitoring, gout, chronic kidney disease, lung embolism, acute coronary syndrome, diarrhea, thyroid disease, sexually transmitted disease, rheumatoid arthritis and obesity.

Eligibility criteria:
inclusion criteria: * primary care practices will be considered eligible if all the physicians active in the practice agree to be involved in the study * all family physicians will be considered eligible if they: * collaborate with either mch, anacura or aml for their laboratory test orders * agree to use the online cpoe for their laboratory test orders * use a computerized ehr for patient care * agree to the terms in the informed consent exclusion criteria: * primary care practices where one or more physicians refuse to be enrolled will be excluded

Keywords: order sets decision support laboratory test primary care
68ga-nota-nfb: radiation dosimetry in healthy volunteers and applications in glioma patients or breast cancer patients

Conditions: Glioma; Breast Cancer

Summary: the purpose of this study is to assess the safety, biodistribution, dosimetric properties of the positron emission tomography (pet) radiopharmaceutical agent 68ga-nota-nfb. to preliminarily evaluate its application in glioma diagnosis. to assess the application of 68ga-nota-nfb pet/ct in the evaluation of the neoadjuvant chemotherapy in patients with breast cancer before and after the therapy.

6 healthy volunteers with whole-body pet/ct scans 0, 0.5, 1.0, 2.0, and 3.0 hours after tracer injection (mean dose, 4.93 ± 0.10 mci) will be performed. during the imaging period, 1 ml blood samples will be obtained specifically at 1, 3, 5, 10, 30,60, 90, 120, 150, and 180 minutes after the injection, for time-activity curve calculations. the estimated radiation doses will be calculated by using olinda/exm software. 8-10 patients with glioma will be enrolled for the clinical study of diagnosing glioma, they will be performed with both 68ga-nota-nfb pet/ct and18f-fdg pet/ct scans before surgery. the preoperative images are compared and correlated with the pathologically report. next, the expression of cxcr4 will be determined by immunohistochemical staining of the resected brain tumor tissues. 30 patients with breast cancer will be underwent 68ga-nota-nfb pet/ct and18f-fdg pet/ct scans before and after the neoadjuvant chemotherapy. suv of lesions before and after therapy will be contrasted.

Eligibility criteria:
inclusion criteria: * volunteers : healthy patients with glioma: diagnosed by mr and ready for surgery patients with breast: cancer appropritate of neoadjuvant chemotherapy. exclusion criteria: * patients with glioma: refuse or cannot endure surgery. patients with breast: refuse neoadjuvant chemotherapy.

Keywords: chemokine receptor galium dosimetry glioma
esophageal safety of high and very high power short duration pulmonary vein isolation: a randomized comparison of the 50w and 90w power settings

Conditions: Atrial Fibrillation (AF); Esophageal Perforation; Esophageal Perforation, Traumatic

Summary: pulmonary vein isolation (pvi) is the most effective means of maintaining sinus rhythm in atrial fibrillation (af), while a widely used approach to pvi is point-by-point radiofrequency (rf) catheter ablation. high power short duration (hpsd) and very high power short duration e.g., 90w and 4 sec) are increasingly popular technologies, featuring higher power and shorter application durations compared to previous methods. vhpsd offers similar efficacy to hpsd, while further reducing procedure times. atrioesophageal fistula (aef) is a rare but deadly complication of pvi, while endoscopically detected esophageal lesions are surrogate markers for the risk of aef. furthermore, thermal complications include vagal lesions leading to gastroparesis. while there is considerable data on the thermal safety of hpsd technology, most studies of vhpsd focus on efficacy and a direct comparison in terms of esophageal safety is lacking. in this randomized, single-center study, we aim to compare the thermal safety of vhpsd to hpsd. furthermore, we aimed to determine the anatomical and biophysical factors that predict thermal injury. patients undergoing their first pvi for af are randomized to either hpsd or vhpsd power setting. the primary endpoint of the study is the composite of esophageal mucosal lesion and gastroparesis, as assessed at the post-procedural endoscopy within 15 days after the pvi.


Eligibility criteria:
inclusion criteria: - patients with paroxysmal or persistent atrial fibrillation undergoing their first pulmonary vein isolation procedure exclusion criteria: * additional ablation performed outside pvi * contraindications to postoperative upper endoscopy

Keywords: pulmonary vein isolation pvi hpsd high power short duration esophageal injury
the safety and efficacy of universal car-t cells targeting bcma in the treatment of refractory nmosd

Conditions: Autoimmune Disease

Summary: this is an open label, multi-center，dose-escalation study in up to 18 participants with refractory nmosd. this study aims to evaluate the safety and efficacy of universal car-t cells targeting bcma in the treatment of refractory nmosd.

this is a multi-center, single-arm, open-label clinical study, and the sample size is set to 12-18 subjects. based on the "3 + 3" dose escalation design principle, subjects will be divided into 3 groups from low dose to high dose in sequence (group a; group b; group c).

Eligibility criteria:
inclusion criteria: * aged 18-65 years ; both genders eligible. * meets the criteria for refractory nmosd. * anticipated survival of ≥ 12 weeks as judged by the researcher. * agrees to use double barrier methods, condoms, oral or injectable contraceptives, or intrauterine devices during the study period and for one year after taking the study medication. * provides written informed consent. exclusion criteria: * history of solid organ transplantation. * malignant tumor within the last two years. * positive for hepatitis b surface antigen (hbsag) or hepatitis b core antibody (hbcab), with peripheral blood hepatitis b virus (hbv) dna detected as positive; positive for hepatitis c virus antibodies, with peripheral blood hepatitis c virus rna detected as positive; positive for human immunodeficiency virus (hiv) antibodies; positive for cytomegalovirus (cmv) dna; positive for syphilis. * primary immunodeficiency (congenital or acquired). * severe cardiac disease. * history of psychiatric disorders or history of psychotropic drug abuse, with no history of withdrawal. * allergic constitution or a history of severe allergies. * pregnant or breastfeeding women.

Keywords: universal bcma cart aqp4 antibody positive refractoryneuromyelitis optica spectrum disease
achievement of goal resting heart rate on b-blockers in patients with stable angina and hypertension

Conditions: Stable Angina; Hypertension

Summary: this is a multicenter survey of russian data on target heart rate achievement in patients with stable angina and arterial hypertension who are currently treated with beta-blockers for at least 2 months and with no dose change for a minimum of 4 weeks


Eligibility criteria:
inclusion criteria: * stable angina i-iii class by the canadian cardiovascular society classification and concomitant primary hypertension * subject is on beta-blockers treatment for at least 2 months prior to inclusion into survey, with no dose change for a minimum of 4 weeks exclusion criteria: * use of phenylalkylamine and benzothiazepine calcium channel blockers * hemodynamic significant mitral and aortic valve disease * acute myocardial infarction and unstable angina within 3 months before enrolment

Keywords: resting heart rate stable angina hypertension beta-blockers
cardiopulmonary exercise testing as an outcome predictor in coronary artery bypass surgery

Conditions: Coronary Artery Disease; Surgery--Complications

Summary: this is a prospective cohort study of patients undergoing coronary artery bypass graft surgery. prior to surgery, participants will undergo submaximal cardiopulmonary exercise testing on a treadmill. participants will be followed for one month after surgery to assess mortality and non fatal complications.

coronary artery bypass surgery (cabg) is a complex and expensive procedure with great potential for morbidity and mortality. preoperative evaluation is of paramount importance to optimize results. there is much evidence about the benefits of the cardiopulmonary exercise testing (cpet) in the evaluation of preoperative risk in non-cardiac surgeries. thus, it is important to evaluate the relationship between parameters obtained in the cpet and the outcomes after cardiac surgery, especially cabg. this is a prospective cohort study in which participants undergo submaximal cept on a treadmill prior to cabg. participants will be followed up for one month after surgery to assess mortality and non fatal complications. it is expected that poor cardiopulmonary fitness is related to worse outcomes in cabg, as already observed in other cardiac pathologies and in non-cardiac surgery.

Eligibility criteria:
inclusion criteria: * patients undergoing coronary artery bypass grafting surgery at the national institute of cardiology, ministry of health, rio de jnaeiro, brazil. exclusion criteria: * angina ccs iv, heart failure nyha iv, inability to walk on a treadmill, severe left main coronary artery lesion.
physiology of vestibular dysfunction and clinical implications

Conditions: Dysfunction of Vestibular System; Accidental Falls; Frailty

Summary: vestibular dysfunction is a known contributor to imbalance and fall risk, and may be a precursor to the frailty phenotype seen in the elderly population. a recent study found that vestibular dysfunction is common in the us population, and that the prevalence of this impairment increases steeply with age. however, it is unknown whether the aging process has global effects on the vestibular end-organ or whether specific structures, e.g. the semicircular canals or the otoliths, are selectively impaired. moreover, the clinical implications of specific deficits of the vestibular end-organ are unclear. as such, the aims of this proposed research are: 1) to evaluate whether the normative aging process is predominantly associated with dysfunction of the semicircular canals (as measured by caloric and angular vestibulo-ocular reflex testing) or of the otoliths (as measured by vestibular-evoked myogenic potential (vemp) testing); 2) to determine if there are any characteristic clinical features associated with the subtypes of vestibular dysfunction; and 3) to assess whether dysfunction of the semicircular canals or of the otoliths is associated with a higher risk of frailty and falls. the investigators plan to pursue these aims through a cross-sectional and prospective cohort study of a group of individuals age 70 and above. vestibular physiologic tests will be administered to all study participants, and test results will be correlated with baseline clinical symptoms and frailty status as well as prospective one-year fall risk. a greater understanding of vestibular physiologic deficits and clinical implications in older individuals can inform the development of rational vestibular rehabilitation strategies that may more effectively mitigate the frailty phenotype and reduce fall risk.


Eligibility criteria:
inclusion criteria: * participant's age is 70 years and over? * participant is willing and able to give informed consent? exclusion criteria: * participant has diabetes mellitus * participant has blindness, limited neck range of motion or cervical spine instability
the influence of hip replacement on lower extremity hemodynamics in crowe iv hip dysplasia patient

Conditions: Hip Dysplasia

Summary: explore the influence of hip replacement on lower extremity hemodynamics in crowe ⅳ hip dysplasia patient.

changes of limb length after total hip replacement is common, especially for crowe ⅳ hip dysplasia patient. such change potentially increases tension of vessel and influence lower extremity hemodynamics. till now, little is known in this area.

Eligibility criteria:
inclusion criteria: * unilateral crow iv hip dysplasia; * bilateral crow iv hip dysplasia without osteoarthritis on the other side exclusion criteria: * patients with serious medical disease; * patients with lower extremity vascular disease; 3. patients with severe mental illness.
mindfulness intervention using virtual reality in older adults with symptoms of anxiety and depression in ecuador

Conditions: Symptoms of Depression and Anxiety

Summary: the availability of affordable hardware and rapidly growing content that can be freely accessed in the public domain raises the possibility of vr being used across the world globally and, in a very broad range of settings, including low-income populations and middle-income countries. the goal of this study is implement a randomized control trial using a low-cost vr mindfulness intervention within older adults in quito, ecuador compared. the control group will only receive a check-in phone call.

we created a guided mindfulness intervention using low-cost vr (smartphones and destek v5 headsets) for older adults with anxiety in quito, ecuador. this project is a collaboration between the technology and aging lab at mclean hospital and the universidad san francisco de quito in ecuador. our goal is to recruit 90 older adults with anxiety from various outpatient settings in quito. they will be randomized to control or to the intervention group. the control group gets a phone call in which they are asked how they are doing during 10 weeks. those in the intervention group will receive 10 sessions of mindfulness using vr. we will use the free "sites in vr" app and select different nature scenes for each intervention. the intervention consists of a total of 10 sessions each lasting 30 minutes. in each session, we fit participants with the vr headset with a smartphone running the sites for vr app. the phone, placed in the viewing compartment of the headset, shows a nature scene of the participant's choosing. once participants have acclimated to the scene and understand how to look around the vr scene (by moving their heads in different directions), we will read a mindfulness script with a guided body scan and instructions to engage participants through experiencing the virtual reality nature scene with all senses. the ecuador team was trained by the mclean team on the specifications of the intervention, to review the protocol, and to resolve any problems encountered during the administration of the intervention. the mindfulness sessions will be recorded with video and audio for quality control and intervention supervision to ensure that there is consistency in how the intervention is implemented.

Eligibility criteria:
inclusion criteria: * normal cognitive functioning or mild cognitive impairment determined using the montreal cognitive assessment (moca), being able to give written consent, and being a spanish speaker. exclusion criteria were exclusion criteria: * moderate to severe cognitive impairment, blindness or severe vision problems, deafness or hearing problems, history of dizziness, and current psychosis or mania.