Kornimate/medical-research-clean huggingface dataset:
brexpiprazole (opc 34712) trial in the treatment of adults with major depressive disorder and irritability

Conditions: Major Depressive Disorder and Irritability

Summary: the purpose of this study is to explore the effects of fixed-dosed brexpiprazole adjunctive treatment in subjects with major depressive disorder with irritability


Eligibility criteria:
* inclusion criteria: * are 18 to 55 years of age, inclusive, at the time of informed consent with a diagnosis of a single or recurrent, nonpsychotic episode of mdd as defined by the diagnostic and statistical manual of mental disorders, fourth edition, text revision (dsm-iv-tr™) and confirmed by the mini international neuropsychiatric interview (m.i.n.i.) and an adequate clinical psychiatric evaluation * have received a single, trial-approved ssri or snri at an adequate dose for ≥ 6 weeks prior to screening * have a treatment history of inadequate adt response to at least one adt (but not \> 3) for the current episode. the current major depressive episode must be ≥ 6 weeks in duration. (an inadequate adt response is defined as \< 50% reduction in depressive symptom severity, as measured by subject self-report on the mgh-atrq.) * to be eligible for this trial * have a madrs total score of 20 or more at screening and the phase a baseline, and have a madrs total score of 18 or more at the phase b baseline * have no more than 20% improvement in madrs total score at phase b baseline compared to phase a baseline * have a score of 6 or more on the ksq based on the well being and reversal distress anger-hostility subscales at screening, phase a baseline, and phase b baseline * have anger attacks as documented by the aaq at screening, phase a baseline, and phase b baseline * are right-handed (defined according to the edinburgh handedness inventory) and have normal hearing and normal/corrected-to-normal vision * are willing to discontinue all prohibited psychotropic medications to meet protocol-required washouts prior to and during the trial period * eligibility confirmed through a telephone safer interview with the subject and an independent expert centralized rater * exclusion criteria: * have a current need for involuntary commitment or have been hospitalized within 4 weeks of screening for the current major depressive episode * have a current dsm-iv-tr axis i diagnosis of any of the following: delirium, dementia, amnestic, or other cognitive disorders; schizophrenia, schizoaffective disorder, or other psychotic disorders; bipolar i disorder, bipolar ii disorder, or bipolar disorder not otherwise specified; eating disorders (including anorexia nervosa or bulimia); obsessive compulsive disorder; panic disorder; or post-traumatic stress disorder * have any of the following current axis ii dsm-iv-tr diagnoses: borderline, antisocial, paranoid, schizoid, schizotypal or histrionic personality disorders, or mental retardation * experiencing hallucinations, delusions, or any psychotic symptomatology in the current major depressive episode

Keywords: major depressive disorder mental disorders, nonpsychotic episode, antipsychotic mood disorder, psychotic disorder
analysis of protein expression in serum of koa subjects

Conditions: Knee Osteoarthritis

Summary: in the previous study "using omics technology to explore the mechanism of acupuncture treatment of different acupoints of knee osteoarthritis: a randomized controlled trial (cmuh109-rec3-113)", we found that acupuncture for knee osteoarthritis(koa) significantly reduces inflammation, apoptosis, and metabolism-related serum protein profiles. however, due to the lack of serum protein data from the control group, it is impossible to establish standard values for comparison. to analyze the protein expression in the serum of koa control group subjects, we also measured the spectral energy values of the radial artery pulse wave obtained from the pulse sphygmograph and the meridian energy values obtained from ryodoraku. the results obtained can be compared with previous studies, thus this experiment was designed.


Eligibility criteria:
inclusion criteria: * adults over 50 years old without knee pain exclusion criteria: 1. clinical diagnosis of knee osteoarthritis 2. taking anti-inflammatory and analgesic drugs in the past month 3. taking blood-lipid-lowering drugs or health foods in the past month 4. received any acupuncture treatment in the past 3 weeks
a study of robot-assisted bronchoscopy in chinese participants with lung lesions

Conditions: Lung Neoplasms

Summary: robot-assisted bronchoscopy biopsy procedure will be conducted for all eligible subjects under general anesthesia status by trained investigators in hospital.


Eligibility criteria:
inclusion criteria: * capable and willing to give informed consent * acceptable candidate for an elective, non-emergency bronchoscopic procedure * lung lesions suspected of malignancy, between 8-50 millimeters (mm) in diameter size identified on thin slice (0.9-1.25 mm) computed tomography (ct) scan within 14 days, requiring bronchoscopic biopsy for diagnosis * no more than 1 lung lesion will be targeted for robot-assisted bronchoscopy biopsy exclusion criteria: pre-operative * participants with pure ground-glass opacity lesions on pre-procedure chest ct * participants with the target lesion having endobronchial involvement seen on chest ct * medical contraindications to bronchoscopy and/or anesthesia as assessed by the investigator (such as severe cardiac arrhythmias, severe hypertension, severe cardiopulmonary dysfunction, myocardial infarction, unstable angina pectoris et cetera \[etc\]) precluding safe bronchoscopic procedure
clinical comparative analysis of bretschneider and st. thomas cardioplegia solution in case of mitral valve repair via anterolateral right thoracotomy

Conditions: Mitral Valve Reconstruction

Summary: mitral valve reconstruction via minimal invasive antero- lateral thoracotomy is done in cardioplegia with a cardioplegic solution, either htk-bretschneider (custidiol®) (a crystalloid intracellular solution) or st. thomas (a crystalloid extracellular solution). this study investigates htk-bretschneider versus st. thomas cardioplegic solution regarding peri- and postoperative outcome, especially for cardiac biomarkers.


Eligibility criteria:
inclusion criteria: * mitral valve reconstruction via minimal invasive antero- lateral thoracotomy done in cardioplegia with a cardioplegic solution, either htk-bretschneider (custidiol®) (a crystalloid intracellular solution) or st. thomas (a crystalloid extracellular solution). exclusion criteria: * mitral valve reconstruction via minimal invasive antero- lateral thoracotomy done in cardioplegia with cardioplegic solutions other than htk-bretschneider (custidiol®) (a crystalloid intracellular solution) or st. thomas (a crystalloid extracellular solution).

Keywords: mitral valve insufficiency cardioplegia cardioplegia solution htk-bretschneider (custidiol®) solution st. thomas solution cardiac biomarker
clinical trial comparing tissue adhesive vs. absorbable suture vs. non-absorbable suture

Conditions: Cyst of Face, Neck or Shoulder; Pilomatrixoma of Face, Neck or Shoulder

Summary: standard suture is superior to both tissue adhesive (2-octyl cyanoacrylate) and absorbable sutures with respect to cosmetic outcome of, complication rate of and parental satisfaction with the closure of low tension facial, neck and shoulder, wounds in children and adolescents


Eligibility criteria:
inclusion criteria: * age less than or equal to 18 * pre-operative diagnosis of cyst or pilomatrixoma of neck, face or shoulder * outpatient scheduled for outpatient or day surgery at children's hospital san diego exclusion criteria: * known hypersensitivity to cyanoacrylate or formaldehyde * lesions with any evidence of active infection or gangrene * lesions on or across mucocutaneous surfaces * lesions in which skin may be regularly exposed to body fluids * lesions located in areas of dense natural hair (ie scalp) * patients with peripheral vascular disease, insulin dependent diabetes mellitis or blood clotting disorders * patients with known immunodeficiencies * inability to return for follow-up
lx102 in patients with neovascular age-related macular degeneration (namd)

Conditions: Neovascular Age-Related Macular Degeneration

Summary: the goal of this study is to evaluate the safety and efficacy of lx102 gene therapy for namd.

this study will enroll subjects aged ≥ 50 years old to receive a single unilateral subretinal injection of lx102 to evaluate its safety and efficacy.

Eligibility criteria:
inclusion criteria: 1. willing to sign the informed consent, and willing to attend follow-up visits. 2. age ≥ 50 3. diagnosis of active cnv secondary to neovascular amd 4. bcva etdrs letters between 5 and 63 5. subjects must have received a minimum of 2 injections within 6 months prior to screening 6. demonstrated a meaningful response to anti-vegf therapy exclusion criteria: 1. cnv or macular edema in the study eye secondary to diseases other than namd 2. retinal detachment, uveitis, uncontrolled glaucoma in the study eye, or any condition preventing visual acuity improvement 3. acute coronary syndrome, myocardial infarction or coronary artery revascularization, cva, tia in the last 6 months 4. uncontrolled hypertension defined as average sbp ≥160 mmhg or an average dbp ≥100 mmhg 5. uncontrolled diabetes defined as hba1c \>7.5%

Keywords: age-related macular degeneration amd neovascular amd neovascular age-related macular degeneration
transplant optimization using functional imaging (trofi)

Conditions: Bronchiolitis Obliterans; Lung Transplant Rejection

Summary: the objective of this study is to detect bronchiolitis obliterans syndrome (bos) in an early stage using the outcome parameters generated by functional respiratory imaging (fri). robust and automated segmentation algorithms will be developed for these parameters, focusing on quantitative computed tomography (ct) image analyses to provide the physician a more sensitive diagnostics tool. the evolution of bos over time will be monitored using nmon-rigid image registration methods.


Eligibility criteria:
inclusion criteria: * male or female patient ≥ 18 years old * written informed consent obtained * patient who had undergone a lung transplant a year ago or more * female patient of childbearing potential who confirm that a contraception method was used at least 14 days before screening visit and will continue to use a contraception method during the study * the patient must be able to perform the lung monitoring at home * patients diagnosed with bos 0, bos 0-p or bos 1 exclusion criteria: * pregnant or lactating female * known history of or active airways or anastomotic complications requiring intervention such as stenting or dilation

Keywords: hrct high resolution computed tomography scans functional respiratory imaging fri computed tomography ct bronchiolitis obliterans syndrome bos lung transplant
an internet-delivered intervention for coping with adhd in adulthood

Conditions: ADHD

Summary: the primary aim of this study is to examine the efficacy of a self-guided internet-delivered intervention for coping with adhd. the secondary aim is to investigate the effects of individual adaptation of the intervention on adherence, satisfaction and clinical outcomes.

adhd in adulthood, with an estimated prevalence of 2 - 3 %, is associated with challenges in daily life functioning. the availability of evidence-based psychological interventions for adults with adhd is poor. interventions delivered over the internet might help to increase the availability of effective psychological interventions for this group. the primary aim of this study is to examine the efficacy of a self-guided internet-delivered intervention for coping with adhd. the secondary aim is to investigate the effects of individual adaptation of the intervention on adherence, satisfaction and clinical outcomes. a minimum of 118 participants with a self-reported adhd diagnosis will be included in the study. in phase 1 we will conduct a randomized controlled trial with two arms, 1) self-guided internet-delivered intervention for coping with adhd (n=59), 2) self-guided online psychoeducation (control group, n= 59), with a 3 month follow-up. after 3 months the second phase of the study starts. in this phase (ii) the control group participants will receive an adaptive version of the internet-delivered intervention. this includes adaptation of the order of the modules to the individual participant needs, with the use of rule-based and machine-learning based adaptation. clinical outcomes in both phases are inattention, hyperactivity, quality of life and stress. uptake, usage, adherence and satisfaction will be explored. repeated measurers are at baseline, weekly during the intervention period, post-intervention and 3 months follow-up.

Eligibility criteria:
inclusion criteria: 1. adults with a self-reported diagnosis of adhd (date, venue and diagnosing physician) 2. access to and ability to use a computer, smartphone and the internet. 3. current problems with organizing daily activity and 17 points of more on at least one of the asrs subscales 4. participant are by investigators considered able to follow through the training protocol and take part in measures taken during the study time frame 5. speaks, writes and reads norwegian exclusion criteria: 6. current self-reported diagnosis of severe psychiatric illness such as borderline or antisocial personality disorder, bipolar disorder, ongoing substance abuse, and/or suicidal ideation assessed with item 9 on the madrs 7. participants who are taking prescribed adhd medication have to be stable on the medication at least four weeks before the study and during the study.

Keywords: adhd rct internet-delivered intervention self-help coping
vitamin d and prostate cancer: a clinical study enrolling subjects undergoing prostatectomy

Conditions: Prostate Cancer

Summary: the study population will be 80 adult men who have been diagnosed with prostate cancer who are scheduled to have their prostate surgically removed at either the medical university of south carolina (musc) or the ralph h. johnson vamc, both located in charleston, sc. the men will be randomized into two groups: one group will take vitamin d3 supplementation and the other will take a placebo. blood levels of vitamin d3 will be obtained at the beginning of the study and again after two months, just prior to the surgical procedure (prostatectomy). prostate tissue will be obtained from the surgical procedure and studied for the effect of vitamin d on the prostate cancer cells.

this study will enroll 80 (40 per study arm) subjects (\>18 years of age), recently diagnosed with prostate cancer (histologically documented adenocarcinoma of the prostate), who are scheduled to undergo prostatectomy. eligible subjects will be recruited in the urology clinic at musc or ralph h. johnson vamc. all subjects will be refered to the study by their urologist. at the baseline visit, consent will be obtained before any study procedures are initiated. a blood sample will be obtained for 25(oh)d3 analysis. subjects will be randomized to either the intervention group (vitamin d3 4000 iu daily) or the placebo group and take the study medication for approximately two months before their scheduled prostatectomy. the final study visit is the day of surgery. a blood sample for 25(oh)d3 analysis will be obtained. prostate tissue will be collected from the pathologist for (a) genomics (rna sequencing) analysis; (b) proteomics (proteins, glycons and lipids) analysis and (c) vitamin d receptor (vdr) by immunohistochemistry.

Eligibility criteria:
inclusion criteria: * diagnosis of prostate cancer (by prostate biopsy) * scheduled to undergo a prostatectomy * ability to give his own consent to participate in the study exclusion criteria: * serum 25(oh)d level less than 8ng/ml or greater than 50 ng/ml * vitamin d3 supplementation greater than or equal to 1000 iu daily

Keywords: prostate cancer vitamin d
the effect of blood flow restriction training on lower limb motor function in stroke patients with hemiplegia

Conditions: Hemiplegia and/or Hemiparesis Following Stroke

Summary: flow restriction training combined with routine rehabilitation training can promote the recovery of lower limb muscle strength on the hemiplegic side of stroke patients, improve the lower limb motor function of patients, and further improve their daily life and walking ability. it provides a new treatment method for stroke patients with hemiplegia that leads to lower limb function loss and activity disorder, and the therapy also has the advantages of simple operation, high safety, good patient compliance and low cost, which is worthy of further clinical research and promotion.

in this work, stroke is a disease with a high incidence, high mortality and high disability rate, and it is becoming increasingly common in young individuals. more than 50% of these patients have long-term chronic motor dysfunction due to unilateral limb dysfunction, and abnormal limb movement patterns occur due to unilateral limb weakness, abnormal muscle tone and other symptoms, which can manifest as a typical "hemiplegic gait" on walking. motor dysfunction after stroke, including muscle strength, dystonia and abnormal gait, is the main dysfunction, which can cause cardiopulmonary function decline, thrombosis, muscle atrophy, etc., reducing the ability of daily living and quality of life of patients. routine rehabilitation training methods for stroke patients with dysfunction include muscle strength training techniques, neurodevelopmental treatment (ndt), motor relearning programs (mrps), constraint-induced movement therapy (cimt), neuromuscular electrical stimulation (nmes). but it cannot achieve a good rehabilitation treatment effect. therefore, we found through lower extremity motor function (le-fma), balance function (bbs), activities of daily living (mbi), patients' walking distance (6-mwt test) and the mmt assessment of muscle strength of iliopsoas, quadriceps, hamstrings and tibialis anterior muscles testing that combining blood flow restriction training on the basis of traditional rehabilitation is beneficial for patient muscle rehabilitation.

Eligibility criteria:
inclusion criteria: * the diagnosis of stroke meets the diagnostic criteria revised by the fourth national * conference on cerebrovascular diseases * confirmed by cranial ct and/or mri * first onset, hemiplegia of one limb, clear consciousness, stable vital signs, no serious complications such as heart, lung, kidney, etc., no serious cognitive or audio-visual impairment exclusion criteria: * uncontrolled hypertension * coronary artery disease * uncontrolled autonomic reflex abnormalities * severe spasms * history of fractures or fractures * deep vein thrombosis * cognitive impairment, inability to cooperate
validity and reliability of the turkish version of the neck dissection impairment index

Conditions: Quality of Life; Head and Neck Cancer

Summary: one of the long-term effects of neck dissection applied to patients with head and neck cancer is shoulder dysfunction, which directly affects the quality of life. patients complain of different degrees of shoulder joint problems following neck dissection . shoulder syndrome in these patients is characterized by a set of symptoms including shoulder pain, abduction limitation, and scapular winging.the aim of this study is to make the turkish neck validity, reliability and cultural adaptation of the "neck dissection impairment index".

in the literature, there are many questionnaires aimed at patients with head and neck cancer, developed both specifically and specifically for this patient group, evaluating the quality of life. regarding the shoulder problems experienced by these patients, there is only one item in the literature called "the university of michegan head and neck qol (umhnqol) questionnaire" that evaluates shoulder pain. apart from this, there is no other questionnaire in the literature that may adversely affect the quality of life to neck dissection and question both neck and shoulder problems together. the neck dissection impairment index evaluates the shoulder-related quality of life in a more comprehensive and more detailed manner according to the umhnqol questionnaire. the neck dissection impairment index evaluates the components of shoulder related quality of life in a wide range after neck dissection. because the type of age, weight, radiotherapy and neck dissection are the most important variables affecting quality of life, patients in the high-risk group (e.g. young individuals, patients who have received radiotherapy and modified radical neck dissection) evaluated with the neck dissection impairment questionnaire can benefit from an earlier and more intensive rehabilitation.

Eligibility criteria:
inclusion criteria: * voluntarily accepting to participate in the study * patients whose native language is turkish * patients or healthy individuals who have completed a minimum 11-month recovery period after selective or modified neck dissection exclusion criteria: * having a pathological condition in the neck or shoulder that is not related to the treatments associated with head and neck cancer * cancer recurrence at the time of the evaluations
mortality, morbidity and risk factors of liver retransplantation

Conditions: Liver Transplant; Complications; Liver Transplant Rejection; Liver Transplant Failure; Liver Diseases; Liver Cirrhosis; Liver Failure; Organ Transplant Failure or Rejection

Summary: this study aims to compare the short and long term outcomes of living donor and deceased donor liver retransplantation. bearing that in mind, the investigators will retrospectively analyze the files of patients whom underwent a liver retransplantation in memorial bahcelievler hospital organ transplantation center.


Eligibility criteria:
inclusion criteria: * having a liver retransplantation exclusion criteria: * n/a