Kornimate/medical-research-clean huggingface dataset:
health outcomes of nasopharyngeal carcinoma patients three years after treatment by the ai-assisted home enteral nutrition management

Conditions: Cancer, Carcinoma; Artificial Intelligence (AI); Nutrition

Summary: you have completed the current stage of cancer treatment, after which you need to check regularly and pay attention to nutrition. so we started this study to see if ai could help with nutrition management. main options: option 1: use ai to assist nutrition management; option 2: contact the nutritionist team of the hospital for nutrition management according to your own situation. option 3: do not adopt the first two management methods. special statement: please choose; cancer screening data is used for statistical analysis, but does not reveal any personal privacy.


Eligibility criteria:
inclusion criteria: * malignant tumor patient exclusion criteria: * no
virtual reality exercise program for people with type 2 diabetes

Conditions: Exercise Therapy

Summary: the purpose of this study is to examine the effectiveness of a virtual reality (vr) based rehabilitation protocol for improvement of blood glucose control and exercise compliance of patients. subjects aged 55-85 diagnosed with type 2 diabetes will be recruited. a written consent will be obtained from subjects. subjects recruited will be randomly divided into one of the two groups. the vr group will receive an exercise program conducted in elderly centre or a control group will receive home exercise program. the 12-week exercise program will be conducted three times per week and each session will last for one hour. assessment that takes about one hour to complete will be carried out at baseline, mid-way (6th week) and after the 12-week exercise training. assessment items include physical, psychosocial and cognitive function. also, blood test on hba1c will be carried out at baseline and at the end of the 12-week training. during this course of research, subjects are strongly advised to stay with their present lifestyle and medication.


Eligibility criteria:
inclusion criteria: * individuals aged between 55 and 80 years with a confirmed diagnosis of type 2 diabetes mellitus (t2dm) and an hba1c of ≥ 6.5% and ≤ 11%. exclusion criteria: * individuals will be excluded if they have a history of any of the following conditions: cardiac arrest, complex dysrhythmias at rest, complicated myocardial infarction or revascularization procedure, presence of congestive failure, presence of angina, signs or symptoms of post-event myocardial ischemia, renal impairment or proteinuria, hepatic impairment, severe gout or hyperuricemia or uncontrolled hypertension, a fall within the last year, musculoskeletal impairment such as inability to walk independently (after stroke or serious arthritis), neurocognitive disorder, or other diseases that limit their ability to engage in physical activities will be excluded. individuals enrolled in other physical training programs will also be excluded to ensure any true effect of the proposed intervention can be captured.

Keywords: exercise, diabetes, cognitive function, virtual reality
venovenous co2 removal (vvco2r) in patients with copd and acute respiratory failure

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: the purpose of this study to determine the safety and effectiveness of a mechanical device to remove carbon dioxide from the blood of patients with chronic obstructive pulmonary disease (copd)when they are hospitalized in the intensive care unit for exacerbation of their condition.

this is a pilot study to examine the efficacy and safety of an extracorporeal circuit to remove carbon dioxide (co2) from the blood in patients with an acute exacerbation of copd resulting in acute or acute on chronic respiratory failure. the extracorporeal circuit consists of venovenous configuration through a percutaneously inserted 18 f double lumen catheter placed in a central vein. centrifugal pump and heparin bonded circuit are used and patient is heparinized to maintain an activated clotting time (act) \> 180. circuit blood flow and gas sweep speed will be adjusted to maximize co2 removal and minimize ventilator settings and patient's work of breathing. patients will remain on the extracorporeal circuit for a maximum of four days as tolerated. plasma hemoglobin will be monitored daily.

Eligibility criteria:
inclusion criteria: 1. acute respiratory failure on invasive mechanical ventilation or 2. acute respiratory failure and an advanced directive foregoing invasive mechanical ventilation 3. established diagnosis of copd 4. age group: 18 years or greater exclusion criteria: 1. significant vasopressor support 2. systolic bp \< 100 torr systolic despite vasopressor support 3. class iii or class iv congestive heart failure 4. left ventricular ejection fraction \< 30% by previous echocardiogram 5. recent (6 month) history of myocardial infarction 6. coronary artery disease with unstable angina 7. recent (6 month) history of venous embolism 8. uncontrolled coagulopathy (international normalized ratio (inr) \> 5 or activated partial thromboplastin time (aptt) \> 80s) despite corrective therapy 9. history of heparin-induced thrombocytopenia or other adverse event following the administration of heparin (heparin group only) 10. pregnancy 11. severe chronic liver disease 12. severe anemia (hgb \< 9 gm/dl) 13. any contraindication to systemic anticoagulation with heparin, including recent central nervous system injury or hemorrhage, retinal hemorrhage or other recent hemorrhage from sites which cannot be controlled 14. technically unable to access vessels (obesity, limb deformity, previous surgery at the site, infection, etc.) 15. evidence of increased intracranial pressure or history of an intracranial hemorrhage within the past 3 months
persistent platelet reactivity in acute coronary syndrome

Conditions: Acute Coronary Syndrome

Summary: study of persistent platelet reactivity during acute coronary syndrome. patients are included at admission to the hospital. platelet aggregation is evaluated by platelet function testing after blood sampling during hospitalization. no changes in treatment is planned.

blood samples are performed on day 2 and 4 and collected with usual blood samples and analyzed by the laboratory. maximal aggregation intensity and velocity are measured by light transmission aggregometry induced by arachidonic acid (aa) or adenosine diphosphate (adp). platelet function analyzer will be also used. no changes in treatment in response to the results is planned.

Eligibility criteria:
inclusion criteria: * acute coronary syndrome with elevation in troponin exclusion criteria: * anticoagulant treatment

Keywords: acute coronary syndrome persistent platelet reactivity
study to evaluate the safety and tolerability of abl501, and to determine the maximum tolerated dose (mtd) and recommended phase 2 dose (rp2d) of abl501 in subjects with any progressive, locally advanced (unresectable) or metastatic solid tumors

Conditions: Advanced Solid Tumor

Summary: this is a first-in-human (fih) phase 1 open-label, multicenter, multiple-dose, dose-escalation and dose-expansion study of abl501 to evaluate the safety, tolerability, mtd and/or rp2d, pk, immunogenicity, preliminary anti-tumor activity, and the pd effect of abl501 in subjects with any progressive locally advanced (unresectable) or metastatic solid tumors. this study included 2 parts; a dose-escalation part and a dose expansion part.

this is consisted with dose-escalation and dose-expansion study of abl501 to evaluate the safety, tolerability, mtd and/or rp2d, pk, immunogenicity, anti-tumor activity, and the pd effect of abl501 in subjects with any progressive locally advanced (unresectable) or metastatic solid tumors.

Eligibility criteria:
inclusion criteria: * histologically and/or cytologically confirmed any progressive, locally advanced (unresectable), or metastatic solid tumors that have relapsed or are refractory following the last line of treatment and for which prior standard therapy has been ineffective, standard therapy does not exist, or is not considered appropriate. * subjects with adverse events(aes) excluding alopecia or grade 2 toxicities that are deemed stable or irreversible (e.g., peripheral neuropathy) from prior therapy that have improved to grade 1 or the baseline grade more than 14 days prior to the first administration of study drug. * subject with adequate hematologic, hepatic, and renal functions confirmed based on the screening laboratory test within 7 days prior to the first administration of abl501 exclusion criteria: * subjects has received prior anticancer monoclonal antibody treatment or investigational therapy within 28 days prior to the first administration of abl501 or who has recovered (i.e., =\<grade 1 or at baseline grade) from aes due to previously administered agent more than 14 days prior to abl501 administration. * subject has had prior chemotherapy or radiation therapy within 2 weeks or targeted small molecule therapy within 5 half-lives prior to the first administration of study drug or has not recovered (i.e., =\<grade 1 or at baseline grade) from aes due to previously administered agent more than 14 days prior to abl501 administration * subject discontinued from prior immunomodulatory therapy due to any intolerable immune-related ae(s) (iraes) requiring systemic steroid treatment.

Keywords: lag-3 pd-l1 immune oncology solid tumor bispecific antibody
epidemiology and risk factors for injuries in beach tennis players

Conditions: Sport Injury

Summary: beach tennis, a fast-growing sport since its creation in italy in the 1970s, has rapidly gained in popularity, particularly in la réunion sisland since 2000. however, despite its development, studies on beach tennis-specific injuries are rare, based on cross-sectional studies and therefore limited by temporal or memory bias. the need for prospective research is crucial if we are to gain a better understanding of the epidemiology of injuries and improve prevention and medical management. the aim will be to determine the risk of injury among beach tennis players within a one-year national prospective cohort.


Eligibility criteria:
inclusion criteria: * player declaring that they train regularly in beach tennis (at least once a week) * at least 18 years old at the time of inclusion * male or female * able to read and understand french * whether or not registered within a club * not opposed to the research exclusion criteria: * protected adults (guardianship or curatorship) or those under court protection

Keywords: beach tennis injuries national prospective cohort
investigation to determine safety of taperloc stems with bioguard coating when used in cementless total hip arthroplasty

Conditions: Osteoarthritis of Hip

Summary: prospective clinical investigation to determine the safety of taperloc stems with bioguard coating and exceed abt taperfit acetabular cups with bioguard coating when used in cementless total hip arthroplasty

bioguard safety study: prospective clinical investigation to determine the safety of taperloc stems with bioguard coating and exceed abt taperfit acetabular cups with bioguard coating when used in cementless total hip arthroplasty

Eligibility criteria:
inclusion criteria: * eligible for cementless primary total hip arthroplasty according to the surgical technique brochure (appendix 10): "the taperloc porous primary hip and exceed abt taperfit prostheses are marketed for non-cemented use in skeletally mature patients undergoing primary hip replacement surgery of non inflammatory degenerative joint disease." * under 80 and over 40 years of age * a pre-operative level of pain and function the same as for conventional joint replacement. * a likelihood of obtaining relief of pain and improved function * full skeletal maturity * ability to follow instructions * good general health for age * willing to return for follow-up evaluations exclusion criteria: * patients aged over 80 and under 40 years * known allergy to any antibiotics * active infection * revision arthroplasty * marked bone loss which could preclude or compromise adequate fixation of the device * uncooperative subjects * parkinson's disease * vascular insufficiency of the affected limb, which could compromise bony ingrowth/implant fixation, i.e., diabetes. * severe instability or deformity of the ligaments and/or surrounding soft tissue which may preclude stability of the device * pregnancy * bmi \> 40 * use of immunosuppressive drugs * women of child bearing potential
rotational atherectomy prior to taxus stent

Conditions: Complex Calcified Coronary Lesions

Summary: the primary purpose of this study is to evaluate the long term effects of the polymer-based slow-release paclitaxel-eluting stent (taxus; boston scientific), with or without prior rotablation, in an angiographically well defined group of patients with complex calcified coronary lesions.

calcification is an essential part of all atherosclerotic plaques. its extent increases with the progression of atherosclerotic disease. heavily calcified lesions form a particular threat to des; both damage to the polymer coating during vigorous advancement and inadequate diffusion of the drug to the subintima through extensive calcium arcs could contribute to the ineffectiveness of des when implanted into such lesions, or may lead to primary stent delivery or expansion failure. rotational atherectomy can effectively ablate calcified plaques. in the des era, data concerning rotational atherectomy are scarce. des implantation following rotablation seems a rational combination, but is only poorly supported by controlled studies. in the present study, we are using the polymer-based slow-release paclitaxel-eluting stent (taxus; boston scientific), with or without prior rotablation, in an angiographically well defined group of patients with complex calcified coronary lesions. this prospective, randomized, controlled study aims at evaluating the long term effects of both strategies in this complex cohort of patients.

Eligibility criteria:
inclusion criteria: * angiographically proven coronary artery disease * angina ii-iv° following the canadian cardiovascular society classification criteria and/or reproducible ischemia in the target area by ecg or scintigraphy * the patient signing an informed written consent from the following angiographic criteria, lesions must fulfil all first degree criteria and at least one second-degree criterion to be eligible for inclusion. first degree criteria * de-novo lesion in a native coronary artery * target reference vessel diameter between 2.5 and 4.0 mm by visual estimation * luminal diameter reduction of 70-99% by visual estimation * moderate to severe calcification of the target lesion (clearly defined) second degree criteria * ostial location * bifurcational lesions * long lesions (≥ 15mm) exclusion criteria: * myocardial infarction within 4 weeks * left ventricular ejection fraction \< 30% * limited long term prognosis due to other conditions angiographic exclusion criteria: * unprotected left main lesions * coronary artery bypass graft stenoses * in-stent restenoses * chronic total occlusions * target vessel thrombus * target vessel dissection
cognitive training to promote brain health: implementation and engagement

Conditions: Aging; Mild Cognitive Impairment

Summary: cognition encompasses memory, attention, language and other brain capacities that are necessary for good quality of life and independence. age-related cognitive decline starts at the third decade of life and in some cases can start to impact daily functioning in the late forties. dementia is the most devastating consequence associated with age-related cognitive decline. recent studies indicate that improving cognition by means of intensive computerized brain training can mitigate some aspects of agerelated cognitive decline, and may even have a role in preventing or delaying dementia onset. critically, the capacity of a given individual to improve their cognitive performance after training is fundamentally related to engagement with the exercises. currently, little is known about how to apply intensive computerized cognitive training effectively in the health system, ensuring engagement and best progress. this project aims to tackle this challenge by developing, applying and testing personalized approaches to implement cognitive training in daily life of older adults that were recently evaluated at memory clinics and their care partners. the community readiness approach will be implemented using semi-structured interviews, conducted with subjects that may be interested in cognitive training, key informant, and key stakeholders. using this information, the investigators will design an individualized training program and follow up its application in a feasibility trial. twenty participants, recently evaluated at different memory clinics in ireland, will be recruited, interviewed and invited to engage, over the ensuing 2 to 3 months, in computerized cognitive training. subjects will be assessed after completion of the intervention for training adherence and individual gains on the computerized exercises. in order to gain insight about regional specificities of the approach the investigators will perform a parallel project using the same methodology in brazil. this project is expected to inform the future implementation of cognitive training in public health policies for older adults.


Eligibility criteria:
inclusion criteria: * being evaluated at a memory clinic in the last year, or be the care partner of a person evaluated at a memory clinic * adequate visual and auditory acuity to allow practice on the computerized training exercises * physical ability sufficient to allow performance of the computerized training exercises * provide signed and dated informed consent form. * willing to comply with all study procedures and be available for the duration of the study. exclusion criteria: * any medical condition that precludes performing the computerized training exercises * advanced dementia.
effect of doxepin and nortriptyline on irritable bowel syndrome

Conditions: Irritable Bowel Syndrome

Summary: the objective of this randomized triple blind controlled trial is to compare the effects of doxepin and nortriptyline on diarrhea predominant irritable bowel syndrome. in this stuy, 75 patients with ibs are randomly assigned to receive doxepin , nortriptyline or placebo, a tablet per day, orally, for two months. abdominal pain, mucus in the stool, incomplete evacuation, and bloating are measured and compared between groups at the baseline and one and two month after the intervention.


Eligibility criteria:
inclusion criteria: * presence of diarrhea predominant irritable bowel syndrome according to rome criteria exclusion criteria: * gastrointestinal bleeding * more than 5% weight loss in the last 6 months * presence of any finding in favor of organic disorders in the lab tests or organic disorder in colonoscopy of high risk patients
cerebello-thalamo-cortical coupling in essential tremor

Conditions: Essential Tremor

Summary: essential tremor (et) is a frequent and disabling disorder with progressive worsening of postural tremor of the upper limbs that impairs most of the manual activities of every day life (feeding, drinking, etc.). although the pathophysiology of essential tremor (et) is not fully elucidated, tremor is associated with abnormal activity within different brain regions, in particular the thalamus and the cerebellum. deep brain stimulation (dbs) of the ventral intermediate nucleus of the thalamus (vim-thal) reverses the symptoms of tremor but is an invasive procedure. transcranial stimulation of the cerebellum may represent a non-invasive therapeutic option for et patients. here, the investigators propose to test the efficacy of cerebellar stimulation in 15 et patients previously operated for dbs of the thalamus. to further understand how this treatment provokes tremor reduction, the investigators will analyse the brain neuronal activity in 13 others et patients candidate to thalamic dbs by using combined electrophysiological recordings of the thalamus (with the electrodes implanted), the cerebellum and the cortex with magnetoencephalography.


Eligibility criteria:
inclusion criteria: * age below 75 years * diagnosis of essential tremor according to the criteria of the tremor investigation group and the consensus statement of the movement disorder society group (ref) * health insurance * signed informed written consent exclusion criteria: * other neurological disorders * medications that interact with or influence brain excitability * significant brain lesions detected in mri
lego mri: decreasing the need for sedation, and improving patient anxiety.

Conditions: Stress; Anesthesia; Children, Only; Anxiety; MRI; Sedation

Summary: the objective of the lego®bricks mri project is to study a new play-based tool for use in children preparing to undergo mri and evaluate its ability to reduce the need for anesthesia. a randomized study design will be employed in the experimental "child life" (cl) group, in regard to which child life intervention patients will have. age matched controls will be found retrospectively, and will be patients of the same age, undergoing their first non-contrast brain mri with no child life intervention. patients in the cl group will be prepped by a certified child life specialist with the use of one of the following 2 tools, to be randomly selected: 1. lego bricks model mri (a model of the mri machine and adjacent control room made out of lego bricks) 2. mock mri tube (a six foot long pop-out play tunnel for children, with a diameter of around 17 inches to simulate the mri magnet bore)

diagnostic imaging is frequently utilized in modern medical practice, and various imaging modalities are routinely utilized in the care of pediatric patients. magnetic resonance imaging (mri) is an advanced imaging modality that is utilized to evaluate many conditions in pediatric patients. mri is frequently favored over other imaging modalities in pediatrics since it allows for high-quality cross sectional imaging without the use of potentially harmful ionizing radiation, to which children are more sensitive than adults. however, mri quality is highly dependent on patients' ability to hold still and follow instructions, which is often challenging in pediatric patients. young and uncooperative children often require anesthesia to successfully complete mri. anesthesia can often be avoided with the assistance of certified child life specialists, who use techniques to reduce patient anxiety and improve children's ability to follow instructions during mri. for example, children may visit the mri unit or a simulator prior to the examination to contextualize the procedure1-3. preparation, in the form of play, has been proven to reduce anxiety in children prior to scans and invasive medical procedures. children who are prepared for medical procedures experience less fear and anxiety and will have better long term adjustment to medical challenges (koller, 2008).

Eligibility criteria:
inclusion criteria: * between 4 and 10 years of age * undergoing first mri * mri brain without contrast exclusion criteria: * diagnosed serious illness/mental disability * have undergone prior mri