Kornimate/medical-research-clean huggingface dataset:
the safety and efficacy of peri-procedure blood pressure management of revascularization

Conditions: Cerebral Revascularization; Ischemic Cerebrovascular Disease

Summary: objective: referring the relation between cea(carotid endarterectomy) postoperative blood flow monitoring and blood pressure, and combining patient demographics and preoperative risk factors to establish an applicable individual blood pressure controlling model. by comparing with routine antihypertensive strategies through prospective randomized controlled trials , to provide the best perioperative blood pressure control standards and strategies for each patient ,thus better ensuring the safety and efficacy of cea .


Eligibility criteria:
inclusion criteria: * symptomatic patient with carotid artery stenosis\>=50% or asymptomatic patient with carotid artery stenosis\>=70%, according to dsa or cta; * without massive cerebral infarction(infarction area \>1/2 territory of middle cerebral artery) confirmed by ct or mri; * informed consent acquired. exclusion criteria: * lesion beyond range limit of procedure (higher than c2); * target vascular complete occlusion or ipsilateral intracranial artery severe stenosis or complete occlusion cannot be revascularized via cea procedure * nonatherosclerotic carotid stenosis, such as vasculitis, dissection, congenital vascular malformation; * history of instable angina pectoris, myocardial infarction or congestive heart failure within 6 months unable to accept systematic anesthesia; * history of severe injury, surgery or radiotherapy on neck; * with comorbid hemorrhagic cerebral disease such as intracranial aneurysm or vascular malformation; * with comorbid blood system disease causing refractory coagulation dysfunction or rejection to blood or blood products perfusion; * with other comorbidity, expected life \< 2 years; * severe diabetes mellitus difficult to control, blood sugar \>300mg/dl; * pregnancy or peri-natal period; * intolerance to systematic anesthesia or surgery after adequate preparation. * intolerance to peri-procedural drug possible to administrated; * not cooperating or rejecting to informed consent;
contributions of a paramedical approach in the prevention and treatment of side effects associated with radical prostatectomy

Conditions: Prostatic Neoplasms

Summary: the paramedic urology team at martinique university hospital has developed a "personalized rehabilitation oncosexology program for patients undergoing radical prostatectomy (rp) for localized prostate cancer". the aim of this project is to assess the effectiveness of this program by comparing the sexual quality of life 1 year after surgery between patients participating and those who do not.

80% of patients undergoing radical prostatectomy report urinary incontinence and erectile dysfunction \[johanssen et al. 2011. scandinavian prostate cancer group study\]. in the west indies, the incidence of prostate cancer is one of the highest in the world (world-standardized incidence in martinique is 164.5 versus 88.8 per 100,000 person-years in metropolitan france). over 2007-2014 an average 530 new cases of prostate cancer were diagnosed each year in martinique, representing 55% of all male cancers \[regional estimates report public health france, january 2018\]. the prostate is a symbol of male vulnerability \[french association of urology-global market research and public opinion specialist, 2006\]. for other authors, virility is above all a cultural representation, and the "crisis of virility", a recomposition of male identity. surgery on a sexual organ can alter body image and masculinity. according to colson et al., patients treated for prostate cancer and their partners clearly place sex in first place in the importance of quality of life domains.

Eligibility criteria:
inclusion criteria: * men diagnosed with localized prostate cancer and consulting in the urology department of mangot vulcin site of the martinique university hospital * patients newly diagnosed for prostate cancer and who will benefit from radical prostatectomy (regardless the technique : laparotomy, laparoscopy or robot-assisted micro-invasive surgery) * fluent in french or creole * patients who give consent * patients affiliated to social security exclusion criteria: * patients diagnosed with another tumor * person under legal protection

Keywords: prostatic neoplasms oncosexology paramedics sexual rehabilitation
role of paclitaxel in stricture urethra

Conditions: Stricture Urethra

Summary: stricture urethra is a common disease and has various causing factors. the most common performed procedure is direct visual internal urethrotomy (dviu), but unfortunately has a high recurrence rates. multiple trial were performed to improve the outcomes of dviu. various intralesional injections were used. in this trial we will evaluate intralesional paclitaxel injection following dviu.


Eligibility criteria:
inclusion criteria: * anterior urethral stricture * short strictures (less than 2 cm) * international prostate symptom score less than 11 and maximum flow rate \< 15 ml per second. * no previous treatment for stricture disease exclusion criteria: * recurrent cases * prior pelvic radiation * associated other pathology or unresolved confounding etiologies (e.g. bladder neck contracture, neurogenic bladder, benign prostatic hyperplasia) were excluded.

Keywords: dviu, stricture, paclitaxel
oeis outcome data registry

Conditions: Peripheral Arterial Disease

Summary: this registry is created under the sponsorship of the outpatient endovascular and interventional society (oeis) to monitor the clinical course and treatment outcomes of patients undergoing office-based endovascular procedures.


Eligibility criteria:
inclusion criteria: * patient is 18 years of age or older; * patient is identified as having undergone a percutaneous transluminal vascular intervention or attempted intervention, in an ambulatory (outpatient) facility, for the treatment of peripheral vascular disease within native arteries or bypass grafts, from the infrarenal aorta distally to the feet. exclusion criteria: * patient treated for a non-eligible condition or procedure * diagnostic procedures without intervention or attempted interventions * serious mental illness that might preclude subject's ability to comply with follow up * life expectancy of less than 6 months
at-home auditory training clinical trial

Conditions: Presbycusis; Aging; Hearing Loss

Summary: the purpose of this study is to investigate the effectiveness of an auditory training program used at home with the subject's own hearing aids.

the most common communication complaint of older adults with impaired hearing is that they can hear speech, but can't understand it. this is especially true where there are competing sounds in the background. previous experiments performed under laboratory settings using a novel word-based auditory-training regimen have demonstrated substantial improvements in open-set recognition of words and sentences in noise. the current proposed study will investigate the effectiveness of the training regimen when used in a patient's home setting with their own hearing aids. all testing for the screening, baseline speech testing, training system orientation, and the outcomes portions of this project will be conducted in the audiology research laboratory (arl) of the speech and hearing center located at 200 south jordan avenue. the use of the training program will be done at the subject's home. subjects will first come to the arl for either one session for a hearing aid follow-up and instruction in the use of the training system (session 1) or for one session for an initial screening to determine eligibility (screening) followed then by session 1. subjects will then take home a training system that includes a tablet computer that has the training program loaded onto it, a portable loudspeaker, and some accessories. there will be three groups of subjects: (1) hearing aid alone--no training (passive control); (2) hearing aid plus auditory training (training); and (3) hearing aid plus audio book use (active control). total enrollment will be 45 subjects. those subjects in the training group and active control group will complete a 6-week training period and return to the lab for outcome measures after 6 weeks of training for the primary and secondary outcome measures. the hearing aid alone group will return for the same outcome measures as the training and active control groups, but will have no intervention between these follow-up sessions.

Eligibility criteria:
inclusion criteria: * •55-79 yrs of age * native english speaker * having corrected vision sufficient to read 18pt font on a computer screen * wearing binaural hearing aids that were fitted within the past 3 years that are the only hearing aids the subject has ever worn exclusion criteria: * the hearing aids worn by the subject will be evaluated on the subject's ears and must be functioning as required for this study; otherwise, the subject will be excluded from participation until the hearing aids have been adjusted appropriately * asymmetrical hearing loss * presence of dementia, parkinson's disease, or other neurological disorder

Keywords: presbycusis aging hearing aids hearing training
single-arm study to evaluate the efficacy and safety of valoctocogene roxaparvovec in hemophilia a patients (bmn 270-301)

Conditions: Hemophilia A

Summary: this phase iii clinical study will assess the impact of bmn 270 (compared to fviii prophylaxis) on the number of bleeding episodes irrespective of exogenous fviii replacement treatment in the efficacy evaluation period (eep) (from week 5 post-bmn 270 infusion (study day 33) or the end of fviii prophylaxis plus the washout period (3 days for products of standard half-life or plasma-derived and 5 days for products of extended half-life), whichever is later, to last visit by the data cut-off for the 2-year analysis, hereafter referred to as "post fviii prophylaxis to last visit"). the study will also assess the impact of bmn 270 (compared to fviii prophylaxis) on: the number of bleeding episodes requiring exogenous fviii treatment in "post fviii prophylaxis to last visit", fviii activity as measured by chromogenic sustrate assay at week 104 following intravenous infusion of bmn 270, usage of exogenous fviii replacement therapy in "post fviii prophylaxis to last visit", health-related quality of life patient-reported outcomes at week 104 following intravenous infusion of bmn 270. the study will also evaluate the safety of the bmn 270.


Eligibility criteria:
inclusion criteria: 1. males ≥ 18 years of age with hemophilia a and residual fviii levels ≤ 1 iu/dl as evidenced by medical history, at the time of signing the informed consent. 2. must have been on prophylactic fviii replacement therapy for at least 12 months prior to study entry. 3. treated/exposed to fviii concentrates or cryoprecipitate for a minimum of 150 exposure days (eds). 4. no previous documented history of a detectable fviii inhibitor, and results from a bethesda assay or bethesda assay with nijmegen modification of less than 0.6 bethesda units (bu) on 2 consecutive occasions at least one week apart within the past 12 months. exclusion criteria: 1. detectable pre-existing antibodies to the adeno-associated virus 5 (aav5) capsid. 2. any evidence of active infection or any immunosuppressive disorder, except for hiv infection 3. any evidence of active infection or any immunosuppressive disorder, including hiv infection (effective as of protocol amendment 3) 4. significant liver dysfunction. 5. prior liver biopsy showing significant fibrosis. 6. evidence of any bleeding disorder not related to hemophilia a. 7. platelet count of \< 100 x 10\^9/l. 8. creatinine ≥ 1.5 mg/dl. 9. liver cirrhosis of any etiology as assessed by liver ultrasound. 10. chronic or active hepatitis b. 11. active hepatitis c. 12. active malignancy, except non-melanoma skin cancer. 13. history of hepatic malignancy. 14. history of arterial or venous thromboembolic events. 15. known inherited or acquired thrombophilia, including conditions associated with increased thromboembolic risk, such as atrial fibrillation.

Keywords: gene therapy clotting disorders blood disorder blood coagulation disorders inherited blood coagulation disorders hematologic diseases coagulation protein disorders hemorrhagic disorders genetic diseases inborn factor viii coagulants
audio-visual relaxation technology for pediatric amplified musculoskeletal pain syndrome

Conditions: Amplified Musculoskeletal Pain Syndrome; Reflex Sympathetic Dystrophy; Complex Regional Pain Syndromes

Summary: a pilot randomized controlled trial to assess feasibility, acceptability and generate outcome domains for a future rct testing the efficacy of immersive virtual reality on pain intensity in pediatric amplified musculoskeletal pain syndrome.

adolescents with amplified musculoskeletal pain syndrome (amps) are invited to take part in this research project that studies two different audio-visual relaxation technologies in reducing amplified musculoskeletal pain. in addition, the investigators are interested in studying if they have an effect on some of the ways adolescents think about their pain and cope with it. both of these technologies provide the user with a similar natural environment designed to have a calming effect, along with guided relaxation and soothing music. the adolescents will be assigned to use one of these for a total duration of about 10 minutes. pain related outcomes including pain intensity, pain catastrophizing and self-efficacy to manage pain will be collected before and after the relaxation session.

Eligibility criteria:
inclusion criteria: 1. a diagnosis of amps, including crps, or localized or diffuse amplified pain syndrome as determined by the primary pediatric rheumatologist and coded in emr. 2. informed consent for caregivers and child assent for participants. exclusion criteria: 1. an underlying organic cause can explain the pain including inflammatory, infectious, traumatic or malignant etiologies as determined by the primary pediatric rheumatologist. 2. participant or caregiver report of any history of motion sickness, underlying epilepsy, severe headaches in the participant or other conditions where the use of visual exposures to stimuli is contraindicated. 3. inability to report a pain score and/or incapacity to give assent due to intellectual deficit. 4. blindness. 5. non-english-speaking subjects will be excluded due to the unavailability of the content of the vr application used in this study in languages other than english. 6. any other condition that the investigators think can compromise the integrity of the study or subject safety.
posaconazole as salvage therapy for aspergillus pulmonary infection.

Conditions: Clinical Infection

Summary: invasive aspergillus infection (iai) occasionally occurs in immunocompromised people. except administrating empirical anti-fungal agent, using objective parameters to support the tentative diagnosis of an iai in order to make the anti-fungal treatment more specifically is also important. at present, serum galactomannan (gm) test is the less-invasive, non-cultural, and time-saving examination for augmenting a diagnosis of aspergillosis. it was suggested by infectious disease society of america (idsa) 2008 as a screening and monitoring tool for aspergillosis , and the cut-off value was adjusted to 0.5 by usa fda . however, in clinical practice, gm seems not to have good predicted value even the sensitivity and specificity are declaimed more than 80% . other controversial issues include the reproducibility of gm5 and the effect of piperacillin-tazobactam or other antibiotics on the accuracy of gm baseline in this study, serum gms are examined in two conditions, one is collected for establishing a baseline and the other is collected after piperacillin-tazobactam administration. we hope to confirm the validity of gm baseline and the effect of piperacillin-tazobactam on gm value in taiwan.

we try to enroll patient who are followed in hematology department in tcvgh and are diagnosed as probable pulmonary aspergillus infection or proven pulmonary aspergillus infection. if they have poor response to current thought effective agent for pulmonary aspergillus (eg, amphotericin b, voriconazole, itraconazole) 2 weeks, then they can choose to receive posaconazole as salvage therapy in our study. however, our study wants to quantification of therapeutic response, so the enrolled patient should be agree to let us check serum galactomannan level at beginning and per 2 weeks. they also should be receive chest ct in the beginning and in the end of posaconazole treatment. the rule out timing is evaluated by clinical doctors (hematology department) per 2 weeks, if posaconazole has poor effect to their disease, the clinical doctors can decided to terminate posaconazole administration. another effective agent will be given when posaconazole fails.

Eligibility criteria:
inclusion criteria: * taichung veterans general hospital hematology and oncology patients with pulmonary aspergillosis, the preliminary use of effective anti-aspergillus drugs (including amphotericin b, itraconazole, or voriconazole) 14 days later, the symptoms worsen or improve, or can not tolerate the side effects. * the default number of subjects 12. exclusion criteria: * children, minors, pregnant women, newborns, prisoners, mental illness, loss of adult decision-making capacity due to illness, the aboriginal ... and other vulnerable groups, and critically ill patients

Keywords: successful percentage
use of illustrated material in communication with the patient in the mechanical ventilator

Conditions: Anxiety; Comfort; Communication

Summary: this study was carried out to determine the effect of the use of communication material on the anxiety and comfort of the patient in communication with patients receiving mechanical ventilators.as a result, the use of communication material reduces anxiety and increases patient satisfaction and comfort level. in communicating with intubated patients receiving mechanical ventilator therapy, the use of illustrated communication material is recommended.

the use ofcommunication material in communication with patients receiving mechanical ventilator support increases patient satisfaction and reduces communication difficulties. however, there was no randomized controlled clinical study showing the effect of the use of these materials on patient care outcomes such as anxiety and comfort level.patients were randomly assigned to the control groups using illustrated communication material and intervention and routine communication methods. the research was carried out in three stages: preoperative, intensive care and one day after surgery. the primary outcomes of the study were pain, anxiety and comfort levels of the patients. secondary outcomes were the patients' satisfaction with hemodynamic parameters and communication method.

Eligibility criteria:
inclusion criteria: 1. having undergone cardiac surgery 2. being applied mechanical ventilator therapy 3. being 18 or over 4. to have scored minimum 2 to maximum 2 from richmond agitation sedation scale (rass) 5. agree to participate in the research. exclusion criteria: 1. not knowing turkish 2. having vision and hearing loss, 3. having a cognitive or psychological problem that prevents them from communicating. 4. having an intubation experience before 5. bleeding, etc. in the early postoperative period. industrial development such as undergoing revision surgery or needing additional sedation,

Keywords: patient mechanical ventilator communication material
pcori-cer-1306-03385 informed decisions about lung cancer screening

Conditions: Lung Cancer; Smoking Cessation; Tobacco Use Cessation

Summary: educational research study where goal is to test educational materials that help people make informed decisions about lung cancer screening.

this is the second phase of a larger project funded by the patient-centered outcomes research institute to help heavy smokers make informed decisions about lung cancer screening with low-dose computed tomography (ldct). the aim of this phase is to compare outcomes for promoting informed screening decisions about lung cancer screening in a randomized trial of patients who smoke recruited through state-based smoking cessation quitlines, where patients will be randomly assigned to the updated patient decision aid or to standard educational materials on lung cancer screening.

Eligibility criteria:
inclusion criteria: 1. men and women 55 to 77 years of age. 2. participants must speak english. 3. current smoker or quit smoking within the past 15 years. 4. at least a 30 pack-year smoking history. exclusion criteria: 1) history of lung cancer.

Keywords: lung cancer screening heavy smokers state-based smoking cessation quitlines patient decision aid low-dose computed tomography ldct standard educational information
ready. set. action! a theater-based obesity prevention program for children

Conditions: Obesity

Summary: the goal of ready, set, action! (rsa) is to test the feasibility of implementing a theater-based after-school program to promote healthy eating, physical activity, and positive body image with children in grades four through six.

the goal of ready, set, action! (rsa) is to test the feasibility of implementing a theater-based after-school program to promote healthy eating, physical activity, and positive body image with children in grades four through six. this study, funded by the national institutes of health (niddk), is a collaboration between the university of minnesota, division of epidemiology and community health, saint paul public schools, and illusion theater of minneapolis. four participating saint paul schools were randomly assigned to receive either a control or intervention after school program led by artists/educators from illusion theater. students in the intervention schools received a fourteen-session curriculum with eight booster sessions, in which they received the following messages: increase fruit, vegetable, and water consumption, decrease soda pop, increase physical activity, and decrease television. families received nutrition and activity information packets themed for each session. the messages were reinforced by theater education, dance, and music. a play structured around the aforementioned messages that included scene vignettes, choreographed dance, and professionally composed music was developed and rehearsed by the children. in december 2006 the children performed the play for their families at illusion theater in downtown minneapolis. they later performed for their peers at school and again for family and school administrators at the conclusion of the program.

Eligibility criteria:
inclusion criteria: * 4th-6th grade children at intervention and control schools * parent or guardian of participating children exclusion criteria: * other ages