Kornimate/medical-research-clean huggingface dataset:
interaction of caffeine and hydration on voice

Conditions: Voice Disorders

Summary: the purpose of the study, effects of interaction of caffeine and hydration on voice performance, is to gather information about the effects of caffeine and hydration upon voice performance. the research question involves whether systemic hydration may reduce degradation on voice performance caused by caffeine ingestion. it is hypothesized that the hydration conditions will result in a less degraded vocal performance as compared with the nonhydration condition.the investigation involves abstention from any caffeine ingestion for 24 hours - from 8pm the day before testing to 8am the morning of testing. in addition, preparation for participation involves abstaining from ingesting any foods and liquids for 12 hours - from 8pm to 8am of the following morning. each test will take about 10 minutes.

the objective of this investigation is to explore the interaction of water and caffeine on voice performance through (a) acoustic measures of voice, and (b) aerodynamic measurements (minimum lung pressure required to initiate phonation. the acoustic and aerodynamic measurements were selected for this study in an effort to demonstrate the effects of four levels of hydration and caffeine status on voice quality: 1) caffeine and water1 (i.e.., experimental group 1 - ingestion of 200 mg of caffeine in conjunction with 500 ml of water), 2) caffeine and water2 (i.e., experimental group 2 - ingestion of 200 mg of caffeine in conjunction with 1.0 liter of water), 3)caffeine only (i.e., experimental group 3: ingestion of 200 mg of caffeine and no water), and 4) control (i.e. no ingestion of caffeine or water). the research question involves whether systemic hydration may reduce degradation on voice performance caused by caffeine ingestion. it is hypothesized that the hydration conditions will result in a less degraded vocal performance as compared with the nonhydration condition. additionally, it is hypothesized that ingestion of 1.0 liter of water will have a greater effect on voice performance than ingestion of 500 ml of water. an additional objective of this study is to increase scientific knowledge of voice functioning by providing further data about the effect of the interaction of water and caffeine on voice performance. the results of this project may be a valuable addition to the scientific literature in vocology, and may also contribute to prevention plans for minimizing vocal disturbances. therefore, vocational programs may include vocal prevention directions based on this study. in addition, knowledge about prevention of voice disorders may be included in the academic curriculum of students enrolled in training programs for professions involving substantial voice use.

Eligibility criteria:
inclusion criteria: * healthy individuals, ranging from 18 to 35 years of age. exclusion criteria: * history of voice disorders, history of coronary disease, history of high blood pressure.

Keywords: voice aerodynamics acoustics
impact of intracoronary versus intravenous epinephrine administration during cardiac arrest .

Conditions: Cardiopulmonary Arrest; Epinephrine Causing Adverse Effects in Therapeutic Use

Summary: in hospital cardiac arrest (ihca) is a major challenge imposed on almost all health care systems worldwide. despite significant progress in cardiopulmonary resuscitation in the past few years, outcomes remain relatively poor with an approximate 49 % survival rate. epinephrine administration remains a cornerstone in the treatment of cardiac arrest. however, the preferred route of administration remains a matter of debate within the medical community . various routes of administration, including intravenous, intramuscular, intraosseous and endotracheal routes have been studied. initially, american guidelines for the treatment of cardiac arrest recommended injection of 0.5 mg of epinephrine directly into the right ventricle through the parasternal approach, aiming to achieve higher peak intracardiac concentrations and a more central effect, however the intravenous route remained preferable due to its feasibility and safety . to our knowledge, intra-coronary epinephrine administration for intraprocedural cardiac arrest has not been evaluated or compared with other routes of administration.


Eligibility criteria:
inclusion criteria: * aged above 18 years old * diagnosed with non-st elevation myocardial infarction (nstemi) or st elevation myocardial infarction (stemi) * received dual antiplatelet therapy (acetylsalicylic acid and ticagrelor), or triple therapy (oral anticoagulant, acetylsalicylic acid and clopidogrel) * event of cardiac arrest during percutaneous intervention exclusion criteria: * cardiac arrest documented prior to being transported to cardiac catheterization laboratory. * patients who suffered cardiac arrest for less than 60 seconds were excluded from the study. * received mechanical circulatory support such as intra-aortic balloon pump, temporary percutaneous ventricular assist devices, or extracorporeal membrane oxygenation (ecmo) during hospitalization. * presenting with any cardiac rhythm on admission other than sinus rhythm or atrial fibrillation/flutter * signs of infection or a history of hepatic, oncologic or allergy to contrast media and end stage renal failure * patients who underwent primary fibrinolysis. * furthermore, patients who received atropine, amiodarone, lidocaine, or any other antiarrhythmic prior to cpr * who received targeted temperature management post cpr .
laparoscopic pyelolithotomy versus percutaneous nephrolothotomy for management of >3cm renal pelvis stone

Conditions: Renal Pelvis Stone >3cm

Summary: to compare the outcome of laparoscopic pyelolithotomy with percutaneous nephrolithotomy in patients with \>3cm renal pelvis stone.


Eligibility criteria:
inclusion criteria: * adults with \>3cm renal pelvis stone exclusion criteria: * history of previous surgery on the target kidney * active uti * coagulopathy
gut-associated lymphocyte trafficking

Conditions: HIV-1 Infection

Summary: the gut immune barrier is not fully restored in hiv-1-infected subjects despite they were receiving antiretroviral treatment. this leaky gut leads to microbial translocation from the gut lumen into the bloodstream that fuels deleterious systemic inflammation. the chemotaxis axes that allow t lymphocytes to migrate from the blood to the gut mucosa in order to reconstitute the mucosal immune barrier seems altered in treated hiv-1-infected subjects.this study aims at better understanding the mechanisms involved in this lack of mucosal immune restoration.

pathophysiological study in human subjects, comparative, national, multicentric and prospective. peripheral blood and intestinal biopsies will be collected.

Eligibility criteria:
inclusion criteria are: for hiv-1-infected subjects group : * age at least 18-year old * hiv-1 infection * receiving continuous cart for ≥ 12 months, started during the chronic phase * plasma viral load ≤50 copies/ml for ≥ 6 months (one blip ≤200 copies/ml authorized) * blood cd4+ t cells count ≥ 350 cells/mm3 * indication for upper and/or lower digestive endoscopy * patient enrolled in or a beneficiary of a social security programme (state medical aid or ame is not a social security programme) * written informed consent. for uninfected control group : * age at least 18-year old * indication for upper and/or lower digestive endoscopy * patient enrolled in or a beneficiary of a social security programme (state medical aid or ame is not a social security programme) * written informed consent exclusion criteria are: for hiv-1-infected subject group : * hiv-2 infection * inflammatory bowel diseases (crohn's disease, ulcerative colitis) ; coeliac disease * platelets count \<50 g/l or abnormal hemostasis tests * decompensated cirrhosis * past or current lymphoma * involvement in an hiv-1 immunotherapeutic vaccine study * pregnant or breastfeeding women * subjects participating in a study excluding participating in another study * vulnerability, such as an age under 18, tutorship, trusteeship, or subjects deprived of liberty by a legal or administrative decision. for uninfected control group : * hiv-1 and 2 infection * inflammatory bowel diseases (crohn's disease, ulcerative colitis) ; coeliac disease * platelets count \<50 g/l or abnormal hemostasis tests * decompensated cirrhosis * past or current lymphoma * pregnant or breastfeeding women * subjects participating in a study excluding participating in another study * vulnerability, such as an age under 18, tutorship, trusteeship, or subjects deprived of liberty by a legal or administrative decision
performance of spectral ct-scan in patients with metastatic colorectal cancer: a prospective multicentre study

Conditions: Colo-rectal Cancer

Summary: spectral ct is a rapidly expanding imaging modality that allows a reduction in iodine dose and irradiation compared to conventional scanning. it uses the difference in attenuation of the material according to the two different energy levels of the incident x-ray beams. the dual-energy scanner has a wide range of clinical applications, particularly in abdominal imaging.

first of all, the virtual creation of mono-energy images between 40 and 140 kev has shown subjective and objective improvement of tumor detection of hypovascular lesions using low energies (40kev). it has been shown to be of interest in vascular and cardiac imaging, and to reduce artefacts in bone imaging. however, its performance in oncology analysis has been little studied. the selection of patients for peritoneal and hepatic carcinosis surgery is fundamental, as surgery allows a prolongation of survival, but are associated with a non-negligible morbi-mortality rate. spectral ct provides improved detection of peritoneal carcinosis and liver metastases of colorectal cancer compared to conventional ct acquisition.

Eligibility criteria:
inclusion criteria: * patients followed for colorectal cancer with synchronous or metachronous liver metastases and/or peritoneal carcinosis * patients with a curative surgical resection plan exclusion criteria: * patients with non-metastatic colorectal cancer * patients treated with chemotherapy without surgical plans * patients with colorectal cancer with extra-hepatic and extra-peritoneal metastases alone (e.g. lung, bone)

Keywords: colo-rectal cancer spectral ct scan liver metastases peritoneal carcinosis
long-term data collection from participants in adult aids clinical trials

Conditions: HIV Infections

Summary: the purpose of this study is to determine what combinations of anti-hiv drugs work best in patients treated over several years. the study will also assess the occurrence of side effects and opportunistic infections in patients with low viral loads compared to those with higher viral loads.

a compilation of outcomes of various antiretroviral therapies would be beneficial when evaluating which strategies are most effective in long-term treatment of hiv-1. using data from present and recently completed studies, this study will collect information on therapies and their control of hiv infection and maintenance of durable suppression of hiv-1 replication. no treatment is provided by this study, but patients will continue to receive highly active antiretroviral therapy (haart) from other studies in which they are coenrolled. blood and urine collection will occur at study entry and periodically throughout the study. women may undergo pelvic exams and pap smears. portions of blood samples will be stored to evaluate genotypic/phenotypic susceptibility testing. medical histories, physical exams, and questionnaires will be completed periodically.

Eligibility criteria:
inclusion criteria * hiv-1 infected * enrolled in an aids clinical trial group (actg) parent study and has enrolled in this study on or before the week 16 visit of the parent study, including the visit window of the parent study. more information on this criterion can be found in the protocol. * willing to provide consent for the release and use of clinical data from the parent study * life expectancy of at least 24 weeks * parent or guardian willing to provide informed consent, if applicable exclusion criteria * active alcohol or drug abuse that may interfere with the study

Keywords: treatment experienced treatment naive virus replication aids-related opportunistic infections hiv-1 risk factors incidence rna, viral anti-hiv agents viral load lipodystrophy nervous system cardiovascular system neurologic symptoms
safe limits in saturation (slim-study)

Conditions: Critical Illness; Hyperoxia; Hypoxia

Summary: a study consisting of a prospective and retrospective cohort in the icu, er and pulmonary department in a university hospital in amsterdam and a teaching hospital in alkmaar, the netherlands. the relationship between the oxygen saturation measured by pulse-oximetry and the arterial pao2 is investigated in order to investigate which transcutaneous saturation values are safe when administering oxygen in relation to hyperopia and hypoxia.

this study consists of two parts a prospective and a retrospective part. 1. prospective part: patients in the icu, the emergency room and the pulmonary function department of the vu university medical centre will be included. arterial blood gas analysis is a tool often used to determine pao2 in regular care. when an arterial blood gas analysis is performed for regular patient care, the corresponding spo2 is measured. information such as blood pressure, heart rate, amount of administered fluids and shock-related-parameters are obtained from the patient files. for the icu patients capillary refill, acra temperature and the mottling scores are examined. the peripheral flow index and temperature index is measured. when more arterial blood gas samples are drawn over time in one patient, multiple datasets can be included per patient, as long as the samples are drawn two hours apart. 2. retrospective part: patients with a (suspected) pulmonary disease who underwent pulmonary function tests with arterial bloodgas sampling in the vu medical center and medical centre alkmaar in the last 25 years. the pao2 and corresponding spo2 will be obtained from the test and parameters such as blood pressure, heart rate and administered oxygen will be retrieved from the databases with these test results.

Eligibility criteria:
inclusion criteria for all inclusions: * age: 18\> * requiring arterial bloodgas analysis exclusion criteria for all inclusions: * hyperbilirubinemia (\>20 μmol/l) * co-hb (\>1,5%) * methb (\>1,5%) * unreliable pulsatile spo2 curve additional inclusion criteria: - prospective, icu - vumc: on mechanical ventilation. arterial line in place. additional exclusion criteria: * prospective, icu - vumc: on extracorporeal membrane oxygenation. therapeutic hypothermia. * retrospective, pulmonary function departments: uncertainty whether spo2 was measured exactly during arterial bloodgas sampling.
therapy of essential hypertension with kinzal®/ kinzalplus®

Conditions: Hypertension

Summary: the efficacy and tolerability of an antihypertensive treatment with telmisartan is followed over 3-4 months


Eligibility criteria:
inclusion criteria: * hypertensive patients seen by the physician requiring antihypertensive treatment exclusion criteria: * according to the local drug information

Keywords: hypertension
pharmacokinetic study of tigecycline in adult subjects with primary biliary cirrhosis

Conditions: Liver Cirrhosis, Biliary

Summary: open label, single dose study of the pharmacokinetics of tigecycline in adult subjects with primary biliary cirrhosis (pbc)

pharmacokinetic study

Eligibility criteria:
inclusion criteria: * men and nonlactating and nonpregnant women greater than or equal to 18 years of age * subjects with biopsy proven primary biliary cirrhosis (pbc) disease in the asymptomatic or symptomatic phase of pbc. * otherwise healthy as determined by the investigator on the basis of medical history, physical examination, clinical laboratory test results (other than those associated with pbc), vital signs, and 12-lead electrocardiogram (ecg). exclusion criteria: * subjects with a recent increase in bilirubin, bilirubin \>15 mg/dl, presence of ascites, esophageal varices, or hepatic encephalopathy. * any major illness that in the investigator's judgment will substantially increase the risk associated with the subject's participation in the study * any malignancy including hepatocellular carcinoma.
internet-based educational program to promote self-management for teens with hemophilia

Conditions: Hemophilia A

Summary: in summary, there is a clear need to improve knowledge and self-management skills in adolescents with hemophilia. to date, there are no published accounts of self-management programs for this population. evidence from other chronic diseases that affects teens suggests that by developing an interactive internet-based program, the investigators can meet the educational needs of adolescents with hemophilia and improve their ability to manage their hemophilia. in the long-term, improved self-management should result in a smoother and more successful transition to adult care and improve patient outcomes.

the overall aim of this program of research is to develop and evaluate the "teens taking charge: managing hemophilia online" internet intervention that will help adolescents with hemophilia to better understand and manage their disease independently. this program is modeled after dr. stinson's similar successful internet self-management program developed for youth with arthritis. this program is being developed and evaluated using a sequential, phased approach. the first phase of this project has determined the self-management and transitional care needs of adolescents with hemophilia. currently, in phase 2a, we are developing the website with the content based on the findings from the phase 1 needs assessment. we propose the current study to conduct usability testing (phase 2b) to make sure it is easy to use and understand, and is efficient and satisfying to complete. subsequently, we will assess the feasibility of the program and the outcomes from the use of the site in a randomized controlled trial (rct) pilot study (phase 3). this will enable us to determine an appropriate sample size for the future mixed controlled trial. phases 2b and 3 are the focus of this proposal. phase 4 will be a multicentre randomized controlled trial to assess outcomes for teens that complete the intervention as compared to those of an attention control group. this randomized controlled trial controlled trial will include all interested pediatric hemophilia treatment centres across canada. we hypothesize that adolescents with hemophilia who complete the "teens taking charge: managing hemophilia online" internet intervention will demonstrate: increased hemophilia specific knowledge, increased self-efficacy, improved health-related quality of life (hrql) and decreased stress prior to transition to adult health care.

Eligibility criteria:
inclusion criteria: * age 13-18 * diagnosis of mild, moderate or severe hemophilia a or b * be able to speak and read english or french. * must have access to the internet at home exclusion criteria * cognitive impairments * haematologist feels that they have a significant medical or psychiatric condition that will impact their participation * don't have access to the internet.

Keywords: teens adolescents internet intervention hemophilia
nutritional intervention for the treatment of uncomplicated sam

Conditions: Child Nutrition Disorders

Summary: nutritional intervention with ready to use therapeutic food (plumpy nut. by unicef) and prebiotics supplimentation ( galactooligosaccarides). will be given to uncomplicated severe acute malnourished children of 06 months to 59 months of age in southern punjab pakistan.one group will be given ready to use therapeutic food and placebo the other group will be given prebiotics supplementation (galacto oligosaccharides) with rutf ( ready to use therapeutic foods).for 60 days primary out will be mid upper arm circumference \>11.5 centimetre

it will be a double blind randomised controlled trial in out therapeutic program centres of teaching hospital of dera ghazi khan pakistan children age of 06 months to 59 months of age from the community will be screened out at health centres . uncomplicated sam children will be enrolled for study before intervention there blood sample and stool sample will be sent to the labs for complete blood examination and complete stool examination. controlled groups will be given ready to use therapeutic food and placebo (starch) 4 grams per day for 60 days intervention group will be given ready to use therapeutic food and prebiotic ( galactoligosaccharides 4 gram per day for 60 days

Eligibility criteria:
inclusion criteria: * uncomplicated severely acute malnourished children exclusion criteria: * severely acute malnourished children with complication
alternative treatments of vitamin d deficiency

Conditions: Vitamin D Deficiency

Summary: the purpose of the study is to compare the efficiency of uvb and vitamin d supplementation in treatment of vitamin d deficiency.

patients with vitamin d deficiency were recruited and randomized into two groups, one exposed to uvb and the other receiving oral treatment with vitamin d supplementation.

Eligibility criteria:
inclusion criteria: * vitamin d deficiency (\< 25 nmol/l) * age 15 or above exclusion criteria: * travel south of 45 degrees latitude during the trial. * ongoing treatment with vitamin d supplementation. * intake of light sensitive medicine, such as tetracyclins. * skin light eruptions

Keywords: vitamin d uvb vitamin d supplementation