Kornimate/medical-research-clean huggingface dataset:
online information on myofascial pain syndrome

Conditions: Myofascial Pain Syndrome, Diffuse

Summary: the investigators aim in this study is to evaluate myofascial pain syndrome (mps) related websites in terms of the quality and the readability of the information. also, to identify the typologies of websites that provide high-quality information about mps.

introduction the reliability of information on the internet, which people use as an easy and practical solution about diseases, is very important for public health. the ivestigatior aim in this study to evaluate the quality and readability of websites related to myofascial pain syndrome. methods on april 4, 2020, web sites were searched on the google search engine by using the term "myofascial pain syndrome". the typologies, quality and readability parameters of the sites were analyzed. websites were divided into eight categories according to typology. in order to evaluate the quality, it is checked whether there is jama scoring system and honcode certificate. flesch-kincaid grade and the simple measure of gobbledygook was used to evaluate readability.

Eligibility criteria:
inclusion criteria: • the url of the first 200 sites exclusion criteria: * the sites in languages other than english * the sites with video and audio recording but without reading text * the sites with access problems or requesting registration * subscription and the sites that do not provide information about myofascial pain syndrome

Keywords: muscle pain online information
alogliptin/pioglitazone (liovel) combination tablets survey on long-term use in patients with type 2 diabetes mellitus

Conditions: Type 2 Diabetes Mellitus

Summary: the purpose of this survey is to examine the safety and efficacy of long-term use of alogliptin/pioglitazone(liovel) combination tablets in patients with type 2 diabetes mellitus determined as warranting combination therapy with alogliptin benzoate and pioglitazone hydrochloride

this is a special drug use surveillance on long-term use of alogliptin/pioglitazone combination tablets. this study is designed to investigate the safety and efficacy of long-term use of alogliptin/pioglitazone combination tablet in patients with type 2 diabetes mellitus in the routine clinical setting. participants will be patients with type 2 diabetes mellitus. the planned sample size is 3000. the usual adult dosage is 1 tablet (containing alogliptin/pioglitazone at either 25 mg/15 mg or 25 mg/30 mg) taken orally once daily before or after breakfast.

Eligibility criteria:
inclusion criteria: * patients with type 2 diabetes mellitus exclusion criteria: * patients meeting any of the following criteria will be excluded: 1. patients with current cardiac failure or a past history of cardiac failure 2. patients with severe ketosis, diabetic coma or precoma, or type 1 diabetes mellitus 3. patients with serious hepatic dysfunction 4. patients with serious renal dysfunction 5. patients with severe infection, pre- or post-operative patients, or patients with serious traumatic injury 6. patients with a history of hypersensitivity to any ingredients of alogliptin/pioglitazone 7. pregnant or possibly pregnant women

Keywords: drug therapy
a community-based screening program to identify participants at high risk for amyloid pathology

Conditions: Alzheimer's Disease

Summary: the primary purpose of this study is to identify participants with or without symptoms of alzheimer's disease (ad) that are at high risk for brain amyloid pathology using blood-based biomarkers.


Eligibility criteria:
inclusion criteria: 1. male or female, age 50 to 80 years inclusive, at the time of informed consent - those 50 to 64 years of age must have 1 of the following risk factors confirmed prior to blood sample collection: * first degree relative with dementia onset before age 75, * known before screening to have at least 1 apolipoprotein e4 (apoe4) allele, or * known before screening to have elevated brain amyloid according to previous positron emission tomography (pet), cerebrospinal fluid (csf), or blood testing 2. provide written informed consent 3. willing and able to comply with all aspects of the protocol 4. willing to be referred to a clinical site if the assessment results meet the criteria exclusion criteria: 1. known uncontrolled medical conditions (example, cardiac, respiratory, gastrointestinal, psychiatric, renal disease, malignant neoplasm) 2. participation in an interventional clinical trial study at the time of consent

Keywords: alzheimers disease blood-based biomarkers community-based screening
pharmacogenetic study for topiramate-induced cognitive dysfunction

Conditions: Cognitive Dysfunction

Summary: topiramate (tpm) is an antiepileptic drug with a unique mode of action that is often useful in patients refractory to other drugs. however its use is restricted by the high incidence of cognitive adverse drug reactions (adrs) that are associated with tpm exposure. tpm has been shown to cause particular cognitive adrs, characterized by verbal fluency, attention, working memory and language deficits, at a much higher rate than other antiepileptic drugs. there do not appear to be obvious differences between patients that do or do not experience cognitive adrs when on tpm (e.g. age, sex, concomitant medications, diagnosis), which suggests a genetic contributor.


Eligibility criteria:
inclusion criteria: * adult (\>17 years old) patients with epilepsy or patients with migraine treated by topiramate exclusion criteria: * allergy to topiramate * abnormal liver or renal function

Keywords: pharmacogenetic study topirmate induced
the effect of open wedge high tibial osteotomy on the posterior tibial slope in skeletally mature patient

Conditions: Genu Varum

Summary: high tibial osteotomy has been established as an efficient surgical intervention for young patients with uni-compartmental osteoarthritis of the knee. the principle of this surgery involves the realignment of the lower extremity to shift the load distribution from the medial compartment into the lateral compartment, thus leading to a decrease in symptoms related to medial compartment knee osteoarthritis however, medial opening wedge high tibial osteotomy is also known to affect the posterior tibial slope angle , and it is reported that posterior tibial slope angle increases after medial opening wedge high tibial osteotomy .

high tibial osteotomy has been established as an efficient surgical intervention for young patients with uni-compartmental osteoarthritis of the knee. medial opening wedge high tibial osteotomy is a well established surgery for patients with medial compartment knee osteoarthritis its most notable advantages include the precision of intraoperative angular correction, absence of the risk of peroneal nerve palsy in fibular osteotomy, absence of leg shortening, and preservation of bone stock. the principle of this surgery involves the realignment of the lower extremity to shift the load distribution from the medial compartment into the lateral compartment, thus leading to a decrease in symptoms related to medial compartment knee osteoarthritis however, medial opening wedge high tibial osteotomy is also known to affect the posterior tibial slope angle , and it is reported that posterior tibial slope angle increases after medial opening wedge high tibial osteotomy . satisfactory outcomes after surgery require optimal realignment both in the sagittal and coronal planes; in fact, poor realignment could lead to unsatisfactory clinical outcomes. an unintentional increase in posterior tibial slope angle after medial opening wedge high tibial osteotomy may influence knee kinematics and stability in the sagittal plane, which could lead to anterior translation of the tibial plateau, anterior shift of the tibiofemoral contact area, and subsequent redistribution of pressure into the posterior tibial plateau (particularly in knees with injured anterior cruciate ligaments). these conditions could result in articular cartilage degradation and further knee disability

Eligibility criteria:
inclusion criteria * age: 20 : 65 years * genuvarus deformity * 70° of range of motion * medial uni-compartmental osteoarthritis. exclusion criteria * posterior instability (relating to the posterior cruciate ligament) * body mass index under 30 * sever genuvarus \> 20 degree
comparison of ultrasound-guided needle aspiration and open incision and drainage for cutaneous abscesses

Conditions: Abscess

Summary: the investigators propose to conduct a, two armed, randomized, controlled pilot study to assess the clinical effects of a) open incision, drainage with daily packing changes, compared to b) ultrasound guided needle aspiration, in drainage of uncomplicated cutaneous abscesses below the skin surface of adult emergency department patients using concealed allocation in evaluating patient satisfaction.


Eligibility criteria:
inclusion criteria: patients presenting to the civic campus emergency department of the ottawa hospital with an abscess less than 5 cm diameter, as judged by the attending emergency physician (measurement with tape measure for diameter) between the hours of 7 am and 10 pm will be approached for possible enrollment. ultrasound will be used to assess the appropriate exclusion criteria. exclusion criteria: * patients under the age of 18 years, * patients with a glasgow coma scale score of \<15 (i.e. not completely alert and oriented), * patients suspected of having necrotising fascitis, * patients with hemodynamic instability (defined as sbp \ 110), * patients admitted to hospital, * patients who are neither french nor english speaking, * patients who are not available for telephone follow-up (i.e. homeless). * ultrasound image demonstrates that the abscess is not compressible (generally indicates that the contents of the cyst includes solids, which would not be amenable to aspiration) * ultrasound demonstrates that there is no abscess to manage, * patients with perianal abscesses who have either crohn's disease or ulcerative colitis or known perirectal fistula, * patients with recurrent abscesses in the same location or abscesses present for more than 2 weeks * patients with complex abscesses including deep tissue, sensitive body part involvement which includes: ears, eyes, lacrimal, orbital, submandibular, mouth, peritonsillar, and bartholin's gland. * patients with renal impairment, diabetes, immunocompromised (as these patients are at risk of becoming more ill if an abscess were able to grow).

Keywords: skin abscess needle aspiration incision and drainage
safety and pharmacokinetics study of pf-04287881 in healthy adults

Conditions: Respiratory Tract Infections

Summary: the purpose of this study is to determine the safety, tolerability and pharmacokinetics of pf-04287881 after a single oral dose in healthy adult volunteers.


Eligibility criteria:
inclusion criteria: * volunteers willing and able to be confined to the clinical research unit and comply with study schedule. * women of non-childbearing potential only. * japanese subjects muct have 4 japanese grandparents who were born in japan. exclusion criteria: * previous antibiotic use within 14 days prior to dosing. * use of antibiotics during hospitalization within 90 days prior to dosing. * history of sensitivity to macrolides or ketolides. * presence of clinically significant eye conditions (other than corrective lenses).

Keywords: safety tolerability pharmacokinetics pk first in human fih
treatment of olecranon fractures in the elderly

Conditions: Olecranon Fracture

Summary: operative treatment, with tension band wiring or plate fixation, will be compared with non-operative treatment of displaced olecranon fractures (mayo classification 2a and 2b) in patients 75 years or older.

displaced olecranon fractures disrupt the extensor mechanism of the elbow and operative treatment is therefore usually recommended. tension band wiring (tbw) and plate fixation (pf) are the most common surgical treatment options. both methods are associated with high complication and reoperation rates, especially in elderly patients. only one randomized controlled trial has compared operative and non-operative treatment of olecranon fractures in the elderly, but the study was stopped prematurely due to high complication rates in the group treated operatively and remained underpowered for important outcome measures.a few small patient series with non-operatively treated fractures also exist and suggest that it may be a valid alternative to operative treatment

Eligibility criteria:
inclusion criteria: * displaced olecranon fracture (mayo 2a and 2b). exclusion criteria: * associated fractures in the coronoid process, radial head or distal humerus. * open fracture, gustilo-andersen 2 or 3 * severe cardiopulmonary disease or other medical condition which contraindicates surgery. * previous injury to or other condition in the elbow with serious functional impairment

Keywords: elderly patients surgery non-operative treatment functional outcome
reduced occupational sitting in type 2 diabetes using mhealth (mobile health)

Conditions: Diabetes Mellitus, Type 2

Summary: type 2 diabetes mellitus (t2dm) patients are suboptimal treated due to low uptake of physical activity. recent research shows promising beneficial health effects from reducing sitting time by regular short bouts of light-intensity physical activity. these findings open up for a new focus in t2dm treatment but conclusive evidence is missing as studies have been short-term trials, mainly conducted in laboratory environments. recent research suggest that reduced sitting and increased physical activity can be supported at a low cost by mhealth (mobile health) technology such as activity tracker armbands that warns of prolonged sitting and sms text messages that reminds of activity breaks. the overarching purpose of the project is to evaluate the effects of an intervention aimed to reduce occupational sitting in t2dm using mhealth (mobile health). it is hypothesized that the intervention will lead to (1) activity changes - reduced sitting time and/or increased number of steps (primary outcome measures) and (2) health effects - lower fatigue, improved health-related quality of life, reduced cardiometabolic risk, less sick leave, less medication, less musculoskeletal problems (secondary outcome measures)


Eligibility criteria:
inclusion criteria: * type 2 diabetes melltitus * 40-64 years * hba1c 48-100 mmol/mol * bmi ≥ 25 kg/m2 * working at least 75% of full-time in a mainly seated job. exclusion criteria: * pregnancy * regular vigorous intensity exercise * severe disease or for other reason unable to follow the study protocol
patient-derived stem cell models of anorexia nervosa

Conditions: Anorexia Nervosa

Summary: experimental and genetic data, as well as brain imaging, support a role of the hypothalamic arcuate nucleus neurons and their communication with surrounding microglia in anorectic conditions, but it has until recently not been possible to explore these cells at a molecular level in anorexia nervosa (an) patients. this attributed to the obvious lack of valid tissue and non-invasive imaging techniques of high enough resolution. stem cell models have evolved as a useful tool for the exploration of other neuropsychiatric disorders with a comparably high genetic contribution as an. the investigators will here use patient-derived induced pluripotent stem cells (ipscs) to profile arc neurons and peripheral blood mononuclear cell (pbmc) derived microglia in an, thus defining molecules to explore as drug targets.


Eligibility criteria:
inclusion criteria anorexia nervosa: * female * 18-45 years of age * an restrictive diagnosis as main diagnosis * more than 5 years duration exclusion criteria anorexia nervosa: - inclusion criteria healthy control: * female * 18-45 years of age * bmi 18,5 - 25 exclusion criteria healthy control: * own or family member with eating disorder diagnosis * own or family member with autism diagnosis
a study of zg19018 in patients with kras g12c mutant advanced solid tumors.

Conditions: KRAS G12C Mutant Advanced Solid Tumors

Summary: evaluate the safety and tolerability of zg19018 in patients with kras g12c mutant advanced solid tumors.


Eligibility criteria:
inclusion criteria: * subjects who fully understood this trial and voluntarily signed the informed consent form; * men or women ≥ 18 years old; * ecog performance status (ps) 0 or 1; * life expectancy \> 3 months. exclusion criteria: * received any treatment with inhibitors against kras g12c mutation at any time, e.g., amg 510, mrtx 849, etc.; * patients requiring medications that can potentially prolong qtc interval; * other conditions that the investigator considers to be unsuitable for participation in this study.
retrieval practice for word learning for deaf and hard of hearing children

Conditions: Hearing Loss; Language Impairment

Summary: this study is designed to advance the promising yet underutilized research on retrieval practice by evaluating the effectiveness and efficiency of two key retrieval practice features (feedback and spacing). the study uses four single case adapted alternating treatments studies, each with four 5- to 8-year-old children who are deaf and hard of hearing to evaluate the effects of feedback and spacing on the efficiency of word learning and retention.

the proposed research addresses a long-standing and important challenge of improving language skills of children who are deaf and hard of hearing, a historically under researched group. the study aims to leverage retrieval practice - an empirically validated intervention approach - for improving how efficiently children who are deaf and hard of hearing learn and retain new words. to advance the promising yet underutilized research on retrieval practice, the study completes the next logical step of evaluating the effectiveness and efficiency of two key retrieval practice features: feedback and spacing. feedback is predicted to result in more efficient learning because it focuses attention on unmastered material, prevents the illusion of success, and reduces repeated errors. spacing trials are predicted to result in more efficient learning than massed trials because they require more effort with fewer cues provided. the study will accomplish these aims through four single case adapted alternating treatments design studies with sixteen 5- to 8- year-old children who are deaf and hard of hearing. study innovations include the critical evaluation of retention and use of a multi-session intervention context. the knowledge gained will guide language intervention for children who are deaf and hard of hearing.

Eligibility criteria:
inclusion criteria: * at least minimal prelingual hearing loss * standard scores of at least 70 for receptive and expressive vocabulary skills * english is only spoken language exclusion criteria: * below average nonverbal cognition * uncorrected vision impairment * evidence of severe motor impairment
ziprasidone in the psychosis prodrome

Conditions: Psychosis Prodrome

Summary: this study aims to determine whether ziprasidone is superior to placebo over 24 weeks for patients with the psychosis prodrome.


Eligibility criteria:
inclusion criteria: * structured interview for psychosis-risk syndromes criteria for clinical high risk for psychosis * clinically referred exclusion criteria: * prolonged corrected qt interval * history of syncope

Keywords: psychosis schizophrenia prodrome ziprasidone placebo
development of a blood test for marfan syndrome

Conditions: Marfan Syndrome; Marfan Related Disorders; Control Subjects

Summary: the objective of this study is to determine whether a simple blood test can be a useful clinical tool for monitoring aortic disease in marfan syndrome and marfan-related disorders.

the primary objective of this study is to determine whether increased quantitites of circulating microfibril fragments, measured with a simple blood test, are associated with aortic root size and increased growth of the aortic root in marfan syndrome and related disorders. the secondary objectives of this study are to: (1) determine a marfan "signature" profile of circulating microfibril fragments. (2) determine if high concentrations of fibrillin-1 fragments are associated with large aortic root diameters. (3) determine which fibrillin-1 fragments are good biomarkers for aortic root growth and size in marfan syndrome. (4) determine the relation between fibrillin-1, aortic root diameter, and medical and lifestyle factors reported on questionnaires.

Eligibility criteria:
inclusion criteria: * age 4-26 years of age for all participants * diagnosis of marfan syndrome, loeys-dietz syndrome, vascular ehlers-danlos syndrome, or familial thoracic aortic aneurysm and dissection for inclusion in marfan and marfan-related disorders groups * diagnosis of unaffected by marfan syndrome and marfan-related disorders for inclusion in control group * able and willing to sign informed consent/assent * signed hippa compliant research authorization exclusion criteria: * other known cardiovascular disorder for unaffected controls

Keywords: marfan syndrome blood test aortic root size marfan related disorders
gene mutation in samples from young patients with pleuropulmonary blastoma syndrome at risk for developing cancer

Conditions: Brain and Central Nervous System Tumors; Hereditary Wilms Tumor; Kidney Cancer; Liver Cancer; Neuroblastoma; Pleuropulmonary Blastoma; Sarcoma

Summary: rationale: the identification of gene mutations in young patients with pleuropulmonary blastoma syndrome may allow doctors to better understand the genetic processes involved in the development of some types of cancer, and may also help doctors identify patients who are at risk for cancer. purpose: this research study studies gene mutations in samples from young patients with pleuropulmonary blastoma syndrome at risk for developing cancer.

objectives: * to determine if dicer1 mutations contribute to tumor pathogenesis in cystic nephromas and cystic partially differentiated nephroblastomas outside of families with pleuropulmonary blastoma (ppb) syndrome. outline: archived dna samples are analyzed for dicer1 mutation by qpcr and directly sequenced using bigdye terminator chemistry. results are then compared against the single nucleotide polymorphism (snp) database.

Eligibility criteria:
disease characteristics: * diagnosis of pleuropulmonary blastoma syndrome * normal tissue samples, if available * parental and sibling dna samples, if available patient characteristics: * not specified prior concurrent therapy: * not specified

Keywords: embryonal childhood rhabdomyosarcoma cystic nephroma neuroblastoma childhood medulloblastoma childhood hepatoblastoma stromal predominant wilms tumor hereditary wilms tumor pleuropulmonary blastoma
sensory effects of rapidly-changing magnetic fields

Conditions: Sensory Disorders

Summary: this study is being conducted to improve magnetic resonance imaging (mri) scans by reducing the time required for imaging. experience has shown that unpleasant side-effects from magnetic pulses used in mri (for example, tingling or tapping sensations) can be reduced when the magnetic pulses are shortened. in this study, we will explore whether this effect holds true when very short magnetic pulses are applied.

see above

Eligibility criteria:
inclusion criteria: * adults over 18, capable of informed consent exclusion criteria: * history of arrhythmia. has implanted pacemaker or defibrillator, right wrist-to-sternum distance of less than 60 centimeters, visible tattoos of the right hand or wrist, or with any metallic objects that cannot be removed from the right hand or wrist. irregular or imperceptible pulse. heart rate less than 50 beats per minute or more than 100 per minute, resting respiratory rate greater than 25 per minute, diastolic blood pressure less than 50. solid meal ingested within 2 hours prior to the study.

Keywords: magnetic fields discomfort