Kornimate/medical-research-clean huggingface dataset:
the predictplusprevent study

Conditions: Depression; Anxiety Disorders

Summary: objective: to design, develop, and evaluate a personalized intervention for the universal prevention of depression and anxiety in the general population based on risk algorithms, icts, and decision support systems (dss). methods: a double-blind, parallel-group, randomized controlled trial with a twelve-month follow-up. the entire process of recruitment, random allocation, intervention, and follow-up will be conducted through the 'predictplusprevent' platform and its associated apps. following a media campaign, at least 9,000 spanish participants aged 18 to 55 years without depression and/or anxiety at baseline will be randomly assigned to the intervention or active control group "predictplusprevent". the "predictplusprevent" intervention will be self-guided and implemented through participants' smartphones via an app; it will have a biopsychosocial and multi-component approach (8 modules: physical exercise, improving sleep, expanding relationships, problem-solving, improving communication, assertiveness, decision-making, and managing thoughts). the "predictplusprevent" intervention is based on validated risk algorithms for depression and anxiety and a dss that will help participants develop their own personalized depression prevention plans, which they will implement themselves while the platform monitors and provides feedback. the active control "predictplusprevent" will include information from the risk algorithms and 24 self-help booklets. the primary outcome will be the incidence of new cases of depression and/or anxiety assessed using the prime-md questionnaire, and secondary outcomes will include reductions in depression (phq-9) and anxiety symptoms (gad-7), probability of depression and anxiety risk (predictd and predicta algorithms), and physical and mental quality of life (sf-12).


Eligibility criteria:
inclusion criteria: * age between 18 and 55 years. * participants must have a smartphone for their own use in the next year. exclusion criteria: * not signing the informed consent. * having depression and/or anxiety at baseline according to the prime-md questionnaire. * living outside of spain. * having a severe mental disorder (psychosis, bipolar disorder, addictions, etc.), a terminal illness or cognitive impairment (dementia). * difficulties in understanding spanish.

Keywords: depression anxiety disorders prevention m-health app randomized controlled trial
the association of protein-energy adequacy with mortality in critically ill patients with acute kidney injury.

Conditions: Critical Illness; Acute Kidney Injury

Summary: this is a prospective observational single-center study in which the association of protein-energy adequacy and 28-days of mortality among critically ill patients with acute kidney injury, aki will be investigated. the association of protein-energy adequacy with a length of icu and hospital stay, total ventilator, and inotropic drug days among critically ill patients with aki also will be investigated.

patients with acute kidney injury, aki are probably more exposed to the risk of malnutrition especially if they undergo renal replacement therapy, rrt. optimization of nutrients especially energy and protein can ensure a better health outcome for critically ill patients with aki. moreover, there is no research on the association of protein- energy adequacy with mortality among critically ill patients with aki in malaysia. so, the main purpose of this study is to investigate the relationship of protein-energy adequacy with mortality among critically ill patients with aki subjects will be recruited upon admission in icu after fulfilling the inclusion and exclusion criteria. they will be follow up from day 1 until day 14 or until icu discharge. data including demographic, clinical, laboratory, and nutritional status will be recorded. on day 28, the outcome data including mortality, length of icu stay, and length of ventilator day will be recorded.

Eligibility criteria:
inclusion criteria: 1. patients who are 18 years old and older 2. patients who are admitted to the participating icu. 3. patients who are mechanically ventilated. exclusion criteria: 1. patients who are less than 18 years old 2. end-stage renal disease patients 3. patients undergo kidney transplantation within 3 months before icu admission 4. pregnant patients 5. the patient is moribund with expected death within 24 hour or whom survival to 28 days is unlikely due to uncontrollable comorbidity (cardiac, pulmonary or hepatic end-stage disease; hepatorenal syndrome; poorly controlled cancer; severe post-anoxic encephalopathy and others) 6. prior treatment with rrt within 30 days 7. anticipated alive icu discharge within 24 hours 8. readmission to the icu during the same hospitalization episode.

Keywords: protein energy adequacy mortality
validity and reliability of indonesian translated ages and stages questionnaires - third edition (asq-3) as a screening tool for developmental delay in 1-12 months old children

Conditions: Developmental Delay; Child Development; Child Development Disorder; Global Developmental Delay; Infant Development; Motor Delay; Speech Delay; Communication Disorders; Development Delay

Summary: this study aimed to provide the validity and reliability of the indonesian asq-3 questionnaires as a screening tool for developmentally delayed children aged less than one year old. this study was divided into 2 phases. the first phase (april-june 2018) included the transcultural adaptation of the asq-3 questionnaires for 2 to 12 months age groups from english to indonesian. the second phase (july- september 2018) included a cross-sectional study of indonesian asq-3 questionnaires for parents/caregivers of children aged 1-12 months, with 35 children in each age group by cluster sampling methods, in 2 district areas in east jakarta.


Eligibility criteria:
inclusion criteria: * parents with children aged 1-12 months * parents who finished at least elementary school exclusion criteria: * parents with communication difficulties * parents who could not speak indonesian language

Keywords: developmental delay developmental screening indonesian asq-3 questionnaire validity reliability
a study of vacyless® versus valtrex® in patients with herpes zoster

Conditions: Herpes Zoster

Summary: the purpose of this study is to compare the safety and efficacy of vacyless® and valtrex® in patients with acute herpes zoster.

primary endpoint: - lesion assessment - rash severity, in terms of rash counts secondary endpoints: * pain assessment * clinical global impression * safety information of valacyclovir

Eligibility criteria:
inclusion criteria: * men and women between 20 to 80 years of age. * patients with a clinical diagnosis of hz as evidenced by a unilateral dermatomal rash. * patients with zoster-related rash (rash severity is greater than or equal to mild). * patients are able to be enrolled into the study 72 hours from appearance of rash (for example, lesions or vesicles). * patients provided written informed consent. * patients who are able to complete all study visits per protocol. * men and premenopausal women must agree to practice a barrier method of birth control or the use of a spermicide for one month after the last dose of study drug (oral contraceptives are not permitted). subject should be withdrew from the study if contraceptions are faild. exclusion criteria: * women who are pregnant or lactating. * patients with multidermatomal or disseminated hz (greater than 20 lesions beyond the dermatomes adjacent to the primarily involved dermatome). * patients with hz ophthalmicus, defined as cutaneous lesions in the dermatome associated with the ophthalmic division of the trigeminal nerve * patients with history of impaired renal function, (e.g., calculated creatinine clearance less than 50 ml/min/1.73 m2) * patients are taking narcotic analgesic routinely for a chronic pain condition * patients are taking tricyclic antidepressants * patients who received systemic antivirals with activity against vzv within the past 30 days, or a topical antiviral to treat their current hz * patients with immunosuppressive or immunodeficient condition resulting from: disease (e.g., hiv) corticosteroid use (except intermittent or topical/inhaled beclomethasone dipropionate or equivalent \< 800 mcg/day), or other immunosuppressive/cytotoxic therapy (cancer chemotherapy or organ transplantation ) * patients with any other condition (e.g., extensive psoriasis, chronic pain syndrome, cognitive impairment) that, in the opinion of the site investigator, might interfere with the evaluations required by the study * patients who are not ambulatory (bed-ridden or homebound); hospitalized patients may be enrolled if they are ambulatory and able to complete the study requirements * patients with history of allergy to valacyclovir hydrochloride and acetaminophen * patients are unlikely to adhere to protocol follow-up
stem cell isolation from femoral heads post total hip arthroplasty

Conditions: Obesity and Type 2 Diabetes

Summary: femoral heads will be collected at university hospital (london, on, canada) from individuals with type-2 diabetes, obesity, and no t2d/no obesity controls. the femoral head will be taken to the robarts research institute (london, on, canada) for lineage-restricted progenitor cell expansion and analyses. there the femoral heads will be used to isolate three stem cell types - multipotent stromal cells, endothelial colony forming cells, and hematopoietic progenitor cells. the yield and cell surface markers expressed on these cells will be measured using flow cytometry. these cell types will then undergo further analyses of the secretome, tubule forming assays, vascular regenerative cell exhaustion assays, and will be transplanted into immune deficient mice with with femoral artery ligation. these experiments are to assess the differences in function and expression of these cell types between individuals with type-2 diabetes and/or obesity and/or healthy controls.

femoral heads will be extracted by dr. lanting (department of surgery - division of orthopaedics) at university hospital, they will then be transferred to robarts research institute where they will undergo cell isolation and analyses. multipotent stromal cells, endothelial colony forming cells, and hematopoietic progenitor cells will be extracted from the bone marrow of the femoral heads. these cells will be used to characterize the difference in regenerative progenitor cell number and potential dysfunction in individuals with type 2 diabetes and/or obesity compared to controls. analysis will include growth kinetics, flow cytometry, bio luminescent imaging and laser doppler perfusion imaging using a fal mouse model.

Eligibility criteria:
inclusion criteria: * must be 18+ years of age exclusion criteria: * diagnosis of bone cancers * diagnosis of rheumatoid arthritis * diagnosis of hematopoietic conditions * diagnosis of avascular necrosis of the hip * does not fall within bmi requirements for experimental groups * cannot read and/or speak in english

Keywords: stem cell diabetes obesity regeneration
efficacy of higher cutting rate in microincision vitrectomy for proliferative diabetic retinopathy

Conditions: Proliferative Diabetic Retinopathy

Summary: the medical records of 393 eyes of 326 patients with severe proliferative diabetic retinopathy were reviewed. higher cutting rate instruments (5000 cut per minute) were used in 174 eyes and conventional instruments in 219 eyes (2500 cut per minute). the visual outcome and incidences of intraoperative and postoperative complications were compared.


Eligibility criteria:
inclusion criteria: * the inclusion criteria were patients who had persistent vitreous hemorrhage, fibrovascular proliferation affecting the macula, or tractional rd and who had a follow-up for more than 6 months. exclusion criteria: * the eyes with follow-up less than 6 months

Keywords: diabetic retinopathy
seroprevalence of bordetella pertussis antibodies and anti-pertussis antibody response after a single dose of tdap in pregnant thai women

Conditions: Pertussis; Pregnancy Related

Summary: this study evaluated the seroprevalence of bordetella pertussis antibodies and anti-pertussis antibody response after a single dose of reduced-antigen, combined diphtheria, tetanus, and acellular pertussis vaccine (tdap) in pregnant thai women. all seronegative participants received tdap, while seropositive participants were equally randomized into 2 groups. half of seropositive participants received tdap and the other half received tetanus-diphtheria (td) as standard protocol.

the primary objective of this study was to determine the seroprevalence of anti-pertussis toxin antibodies (anti-pt igg) among pregnant thai women. the secondary objectives were to evaluate antibody response after tdap vaccination between seronegative and seropositive participants and to compare the different antibody titers at delivery among seropositive participants who received tdap to those who received tetanus-diphtheria vaccine (td). the sample size calculation was based on the primary objective. randomized clinical trial was performed for the latter secondary objective.

Eligibility criteria:
inclusion criteria: * thai pregnant women age at least 18 years * no known underlying disease * singleton pregnancy without maternal or fetal complications * gestational age not more than 20 weeks at the time of recruitment * desired for delivery at siriraj hospital exclusion criteria: * pregnant women who have any contraindication to tdap vaccine including 1. history of serious allergic reaction to any components of tdap vaccine 2. history of seizure or coma after receiving tdap vaccine in childhood 3. having an underlying disease involving central nervous system (e.g., epilepsy, guillain-barré syndrome) * history of serious reactions after receiving tdap vaccine (e.g., severe pain, severe swelling at the injection site) * recently had tdap vaccine injection * denied for tdap vaccine injection
quitline use in surgical patients

Conditions: Tobacco Dependence

Summary: elective surgery represents a teachable moment to deliver tobacco interventions. the overall goal of this proposal is to increase the utilization of the quitplansm helpline by surgical patients who smoke. two specific aims will be pursued using a multidisciplinary research team. in the first aim, we will develop a practice-based intervention to promote quitplansm helpline utilization by surgical patients (specific aim 1a) using a combination of key informant interviews (approximately 30 subjects), and focus groups (approximately 25 subjects) then develop methods to educate providers in its implementation (specific aim 1b) and test their effectiveness in approximately 20 providers. in the second aim, we will perform a randomized clinical trial of this intervention in 300 patients scheduled for elective surgery, with the primary outcome being utilization of the quitplansm helpline (specific aim 2). subjects will be randomized to receive either the intervention developed in specific aim 1, or a brief control intervention.


Eligibility criteria:
inclusion criteria: * patients ≥ 18 yrs. scheduled for elective surgery at mayo clinic rochester. * current smoking before the scheduling of surgery, defined as \> 100 cigarettes lifetime consumption and self-reports of smoking either every day or some days. patients who are in the midst of a quit attempt initiated since learning about surgery are eligible. exclusion criteria: * patient is not available for telephone follow-up

Keywords: surgical patients cigarette smoking postoperative complications telephone counseling quitlines
an implementation and biobehavioral study of temporomandibular joint and muscle disorder (tmjmd)

Conditions: Temporomandibular Joint and Muscle Disorder

Summary: with the great economic costs and traditionally poor outcomes among chronic temporomandibular joint and muscle disorder (tmjmd) patients, it has become important to treat patients in the acute state, in order to prevent these more chronic disability problems. this has been the goal of two past funded grant projects. results of the initial project isolated risk factors that successfully predicted the development of chronicity with a 91% accuracy rate. a statistical algorithm was developed which was used in the second project to screen out "high-risk" patients. these patients were then randomly assigned an early intervention or non-intervention group. one-year follow-up evaluations documented the treatment efficacy and cost effectiveness of early intervention. these results have major implications for effective early intervention and significant health care cost savings for this prevalent pain and disability problem. for the present proposed project, we plan to implement this treatment program in order to evaluate its effectiveness in more community-based dental practices. this is in response to nih's request for the implementation of evidence-based treatment approaches, developed in controlled clinical settings, to the "real world" of diverse practices in the community. acute tmjmd patients will be recruited from two community-based clinics. based upon our "risk" screening algorithm, high-risk patients will be randomly assigned to one of two groups (n=225/group): an early biobehavioral intervention or an attention-control group. it is hypothesized that the attention control "high-risk" patients will display more chronic tmjmd problems, relative to the "high-risk" early intervention patients, at one- and two-year follow-ups. a number of biopsychosocial measures will be evaluated, including chewing performance, the rdc/tmd, self-reported pain and stress, etc. such a multi-level, multi-systems approach has not been applied to better understand the biopsychosocial underpinnings of tmjmd. results from this component of the project will greatly aid in stimulating future research leading to the better understanding of tmjmd, as well as better tailoring of prescribed treatment regimens.


Eligibility criteria:
inclusion criteria: * subject must be an adult aged 18 or older. * subject's first acute jaw pain/discomfort episode must have first developed within the last 6 months exclusion criteria: * younger than 18 years of age * tmd pain/discomfort of greater than 6 months' duration

Keywords: tmjmd acute pain rdc/tmd community treatment clinics rct evidence-based outcomes short- and long-term follow-up biopsychosocial assessment and treatment ability to read and write english 6 months' or less duration of tmd no other pain-related conditions
prevalence of internet addiction among adolescent

Conditions: Internet Addiction

Summary: internet is now a tool available 24 hours a day, at a lower cost and accessible almost anywhere. internet addiction could be defined as the inability to control one's internet use and the continuation of this behavior despite the occurrence of negative consequences. adolescence is a time of vulnerability to addiction, due to social and neurobiological factors.

the aim of the study is to evaluate prevalence of internet addiction among adolescent attending high school

Eligibility criteria:
inclusion criteria: * adolescent attending high school * agreeing to participate in the study exclusion criteria: * none

Keywords: adolescent internet addiction prevalence
knowledge, attitude and practices of flemish midwifes regarding spontaneous abortion

Conditions: Spontaneous Abortion

Summary: kap-study in flemish midwives with intramural employment

the study will be conducted using a self designed questionnaire administered in midwives who are employed within a flemish hospital in one of the following departments: maternity, maternal intensive care, (intensive) neonatology, reproductive medicine, gynaecology, delivery and prenatal care. the questionnaire assesses the knowledge, attitude and practices of the midwives regarding spontaneous abortion.

Eligibility criteria:
inclusion criteria: * midwives who are employed within a flemish hospital in one of the following departments: maternity, maternal intensive care, (intensive) neonatology, reproductive medicine, gynaecology, delivery and prenatal care exclusion criteria: * all others

Keywords: miscarriage flanders spontaneous abortion kap midwives
is there a link between anatomical markers of surgical difficulty and incapacity to reverse stoma after low rectal cancer surgery?

Conditions: Rectal Surgery

Summary: anterior resection with total mesorectal excision (tme) is the standard procedure for mid and low rectal cancers . a colo-rectal anastomosis under peritoneal reflection is, most of the time, protected by a temporary loop stoma to decrease the risk and severity of anastomotic morbidity. this stoma, which is intended to be temporary, appears to be permanent in 6 to 32% of cases in the literature. the main risk factor being anastomotic leakage. two major risk factors for anastomotic leakage after colorectal surgery are " male sex " and " body mass index ", which are responsible of a higher anatomical difficulty (narrow pelvis and bulky mesorectal fat) therefore, the objective of this study is to look for a statistical link between permanent stoma and intraoperative difficulty represented by pelvic anatomical constraints.

anterior resection with total mesorectal excision (tme) is the standard procedure for mid and low rectal cancers . a colo-rectal anastomosis under peritoneal reflection is, most of the time, protected by a temporary loop stoma to decrease the risk and severity of anastomotic morbidity. this stoma, which is intended to be temporary, appears to be permanent in 6 to 32% of cases in the literature. the main risk factor being anastomotic leakage. two major risk factors for anastomotic leakage after colorectal surgery are " male sex " and " body mass index ", which are responsible of a higher anatomical difficulty (narrow pelvis and bulky mesorectal fat) studies focused on surgical difficulties usually evaluated criteria such as, total surgery duration, blood loss or surgeon's subjective evaluation. the investigators of this retrospective study hypothesize that when a stoma,primarily intended to be temporary, is not reversed after a long (2 years) post operative delay, it all comes to surgical difficulties and that these surgical difficulties are essentially represented by anatomical constraints. therefore, the objective of this study is to look for a statistical link between permanent stoma and intraoperative difficulty represented by pelvic anatomical constraints.

Eligibility criteria:
inclusion criteria: * adult patients who underwent a sphincter saving resection for low rectal cancer between january 2019 and december 2017. exclusion criteria: * minor patients. * patients who have undergone a cancer proctectomy with no restoration of continuity expected. * patients who did not have total mesorectal excision
intervention for caregivers of patients who have recently undergone hsct

Conditions: Caregiver Anxiety; Caregiver Distress; Caregiver Health Related QOL

Summary: the purpose of this study is to find out if providing support to caregivers of patients who have recently had a hsct is possible and helpful.

this study will test the feasibility, acceptability, usability, satisfaction and preliminary efficacy of a behavioral (psychoeducation) intervention. all participants will receive the standard post-hospital hsct information for patient follow-up care as provided by the patient's oncologist. in addition, the all participants will receive 4 individual sessions with an interventionist.

Eligibility criteria:
inclusion criteria: * an adult family or friend of a patient who has been discharged from the hospital in the past 1-2 weeks after receiving hsct * identifies himself/herself as the caregiver who will be responsible for the patient's care post-hsct * has english as their primary language exclusion criteria: -not meeting inclusion criteria

Keywords: hematopoietic stem cell transplantation