Kornimate/medical-research-clean huggingface dataset:
a novel balance program to improve balance in people with parkinson's disease

Conditions: Rehabilitation Exercise; Physical Therapy

Summary: the purpose of this exploratory single-blinded randomized control trial is to explore the effects of a lateral stepping program integrated into an existing community-based group exercise program for people with pd. the researchers hypothesize that participation in a lateral stepping program a minimum of 2 times/week for 8 weeks, in addition to rsb class participation, will decrease fall risk factors, increase balance confidence, and decrease fear of falling in participants in the experimental group compared to the control group. the researchers also hypothesize that the integration of this program into an existing community-based rsb program will be deemed feasible as shown by the number of sessions attended by each participant and their satisfaction


Eligibility criteria:
inclusion criteria: 1. a diagnosis of idiopathic pd stages i, ii, or iii of the hoehn and yahr scale 2. 50-85 years inclusive 3. subjects must be enrolled in rsb at ny tech and attend at least 1 day per week for a minimum of 4 weeks prior to the first baseline assessment 4. english speaking. 5. stable pd medication regime. exclusion criteria: 1. any cardiovascular or other medical condition that would affect participation 2. any hip and/or knee surgery or other injury that would prevent full participation in the intervention 3. neurological conditions other than pd 4. montreal cognitive assessment of ≤21 5. pain that interferes with testing 13 6. current participation in other strengthening, stretching or balance programs other than rock steady boxing at ny tech 7. inability to understand and fully participate in this study
screening for sacral agenesis in offspring of mothers with diabetes in pregnancy

Conditions: Infant of Diabetic Mother; Sacral Agenesis

Summary: babies born to mothers with pregestational diabetes will be screened with parental consent for sacral agenesis

parent/s of babies born to mothers with pregestational diabetes who have normal clinical examination and have no radiographs showing a normal sacrum will be approached for a spinal us

Eligibility criteria:
inclusion criteria: * infants born to mothers with pregestational diabetes * normal spinal examination exclusion criteria: * infants born to mothers with pregestational diabetes * abnormal spinal examination such as a sacral dimple * radiograph with abnormal sacrum * spanish speaking parents
pharmacokinetic study of genasense in subjects with normal renal function, mildly impaired renal function, and moderately impaired renal function

Conditions: Normal Renal Function; Mildly Impaired Renal Function; Moderately Impaired Renal Function

Summary: to characterize the pharmacokinetics of g3139 in subjects with normal, mildly impaired, and moderately impaired renal function who receive genasense 3 mg/kg/day by continuous intravenous infusion for 2 days (48 hours).


Eligibility criteria:
key inclusion criteria: * age \> 18 years * adequate organ function as determined \< 7 days prior to starting study medication (except for renal function, as specified per protocol) * creatinine clearance \> 80 ml/min based on the cockcroft-gault formula for subjects in group 1; or 50 to less than or equal to 80 ml/min based on the cockcroft-gault formula and confirmed based on measured creatinine clearance for subjects in group 2; or 30 to 49 ml/min based on the cockcroft-gault formula and confirmed based on measured creatinine clearance for subjects in group 3 key exclusion criteria: * significant medical disease * prior organ allograft * coexisting condition that would require the subject to continue therapy during the treatment (infusion) phase of the study with a drug known to alter renal function

Keywords: renal function adult genasense oblimersen g3139 genta pharmacokinetics
buzzy system compared to topical anaesthesia during infiltration injection in children.

Conditions: Local Anaesthesia

Summary: aim of the study is to test the effect of buzzy system (vibrating device) compared to topical anaesthesia on pain reduction during injection of infiltration anaesthesia in children.


Eligibility criteria:
inclusion criteria: 1. children classified as cooperative or potentially cooperative according to wright's classification of child behaviour with rating 3 (positive) or 4 (definitely positive) according to frankl behaviour rating scale. 2. children aged 5-8 years old. 3. patients who need maxillary buccal infiltration anesthesia. exclusion criteria: 1. children with any neurological or psychological disorders. 2. children with known allergy to topical or local anesthetic agents. 3. parental refusal for participation. 4. children with previous history of local anesthesia injection.
efficacy and safety study of tildrakizumab in the treatment of nail psoriasis

Conditions: Chronic Plaque Psoriasis; Moderate to Severe Nail Psoriasis

Summary: phase 3b study to assess the efficacy and safety of tildrakizumab in the treatment of moderate to severe nail psoriasis


Eligibility criteria:
inclusion criteria: subjects are eligible to be included in the study only if all of the following criteria apply: 1. subjects with a chronic moderate to severe plaque-type psoriasis for at least 6 months (as determined by subject interview and confirmation of diagnosis through physical examination by investigator). 2. subjects must have moderate to severe nail psoriasis at screening and baseline, defined by: * mnapsi score of ≥20. * visenpso ≥3 3. subjects must have moderate to severe plaque psoriasis at screening and baseline, defined by: * s-pga score of at least 3. * body surface area (bsa) involvement of ≥10%. * pasi ≥12 4. subjects must be considered candidates for systemic therapy, meaning psoriasis inadequately controlled by topical treatments (corticosteroids), and/or phototherapy, and/or previous systemic therapy. exclusion criteria: subjects are excluded from the study if any of the following criteria apply: 1. subjects who have predominantly non-plaque forms of psoriasis, specifically erythrodermic psoriasis, predominantly pustular psoriasis, medication-induced, or medication-exacerbated psoriasis, or new-onset guttate psoriasis. 2. subjects with ongoing inflammatory skin diseases other than psoriasis or any other disease affecting the fingernails, which may potentially confound the evaluation of study treatment. 3. subjects with fungal nail infection should be excluded from the study. subjects in whom the investigator suspects a fungal nail infection in addition to nail psoriasis should have scrapings sent for direct microscopy and fungal culture. if fungal culture or direct microscopy of nail scrapings turns out to be positive for fungal infection, the subject should be excluded from the study. at the discretion of the investigator, periodic acid-schiff (pas) staining for nail clippings could also be considered to rule of fungal infection of the nails. direct microscopy or fungal culture are not required if fungal infection is diagnosed in pas staining. 4. subjects with any previous use of tildrakizumab or other il-23/th-17 pathway inhibitors, including p40, p19 and il-17 antagonists for psoriasis. 5. subjects with known history of allergy or hypersensitivity to any of the inactive ingredients of the tildrakizumab or placebo formulations.
the hasselt appendicitis immunology and environmental cohort study

Conditions: Appendicitis

Summary: the hasselt appendicitis immunology and environmental study (happiest) aims at characterizing factors that influence the development and severity of acute appendicitis. in a cohort of 300 patients and 300 controls, environmental factors as well as genetic make-up of the innate immune system, focusing mainly on pattern recognition, will be analyzed in order to gain insight in their relative importance in the pathology of appendicitis. furthermore, populations of micro-organisms present in the gut of patients will be characterized, and the interaction between relevant micro-organisms and the innate immune system will be analyzed.


Eligibility criteria:
inclusion criteria: * acute appendicitis * appendectomy within 7 days after onset of symptoms * signed informed consent exclusion criteria: * appendectomy 7 days or more after onset of symptoms * participation in any clinical investigational drug study within 4 weeks of screening * severe, life-threatening disease with a life expectancy of less than 2 months.
nursing prehabilitation intervention supported with technology for vascular surgery in people with type 2 diabetes

Conditions: Type 2 Diabetes; Lifestyle; Prehabilitation; Vascular Surgery

Summary: type 2 diabetes mellitus (t2dm) is the most common chronic lifestyle-related disorder with a significant impact on quality and healthcare expenditures. insufficient glycemic control and low fitness level prior to a surgical intervention results in more postoperative complications which leads to a longer hospitalization, higher costs and mortality. a prehabilitation intervention in persons with t2dm prior to surgery should be aimed to improve glucose regulation and translate into better outcomes. however, the classic interventions such as combined lifestyle intervention are labor-intensive and require a high degree of organization and therefore are not used as standard care. the use of biofeedback can provide a solution to this. biofeedback with a continuous glucose sensor in combination with lifestyle monitoring by activity trackers and coaching prior to surgery is a promising but unexplored prehabilitation strategy. the nursing prehabilitation intervention supported with technology for vascular surgery in people with type 2 diabetes (vitaaal) intervention is a form of blended care. it focuses on improving vitality and glycemic control before surgery with the diameter application, using intermittently scanned glucose monitoring, nutrition habits and physical activity blended with coaching from a nurse practitioner (np) diabetes. because vitaaal is a novel intervention, the aim of this pilot study is to investigate its usability and feasibility. the pilot study consists of three phases. after the first phase, a specific prehabilitation module will be designed and programmed in the diameter app. this module will be based on the results and experiences in phase one. in phase two and three the patients will use the adjusted version of the diameter app that contains implemented findings of the previous phase.


Eligibility criteria:
inclusion criteria: * patients with t2dm who need a scheduled vascular surgery, consisting of aaa surgery endovascular or classical abdominal approach, aortic stenosis surgery or fontaine ii. * aged 18 years or older * being familiar with using an android smartphone (version 5.0 or higher); * participant can understand and weigh up information provided by researcher and can understand what the consequences of participation are. exclusion criteria: * need for acute vascular surgery * dependency on renal replacement therapy * known with (pre)proliferative diabetic retinopathy with or without macula oedema. * any general diseases or mental disorder rendering participation in the study impossible * drug abuse * insufficient mastery of the dutch language
effect of repetitive transcranial magnetic stimulation (rtms) over the brain on the neurotransmitter binding

Conditions: Stroke; Hemiplegia

Summary: the purpose of this study is to determine whether repetitive transcranial magnetic stimulation (rtms) over the brain can modulate the binding of neurotransmitter (gaba in this study) to its receptor using the special pet study.

repetitive transcranial magnetic stimulation (rtms) can modulate the excitability of cortex but exact mechanism is not well determined in human-beings. changes in some neurotransmitters' status in brain after rtms have been suggested as a possible mechanism, but role of gaba is not clear. twelve healthy people will be recruited. they will receive the rtms over the primary motor cortex of the dominant hand. individual subject will receive three sessions of rtms with wash-out period (more than 3 days) between the rtms sessions. three rtms sessions are high frequency (10hz), low frequency (1hz) and sham rtms. the order of rtms sessions will be randomly decided. after completing each rtms session, \[18f\]flumazenil-pet will be checked. the purpose of this study is to investigate 1)whether rtms over the primary motor cortex can modulate the \[18f\]flumazenil binding potential and 2)whether the modulation of \[18f\]flumazenil binding potential by rtms can be different according to the applied frequency of rtms.

Eligibility criteria:
inclusion criteria: * healthy people * 18-50 yrs old * right handedness * written informed consent exclusion criteria: * previous medical diseases such as seizure, stroke, diabetes, hypertension. * taking any drugs * smoker * pregnancy * contraindication of pet or mri * stroke or any tumor in mri * metals objects in the head or eyes * cardiac pacemaker or cochlear implant

Keywords: neuronal plasticity neurotransmitter agents receptors, neurotransmitter transcranial magnetic stimulation stroke gamma-aminobutyric acid
remimazolam for emergence delirium prevention in patients undergoing rhinoseptoplasty, fess or septoplasty

Conditions: Remimazolam; Emergence Delirium; Rhinoplasty

Summary: the aim of this research is to confirm the effectiveness of remimazolam in preventing delirium during recovery from anesthesia in adult patients who have undergone one of the rhinological surgeries (septoplasty, rhinoseptoplasty or functional endoscopic sinus surgery). patients aged 18-65, asa classification i-ii will be anesthetized with balanced anesthesia maintained with sevoflurane and will be randomized into two groups. the first group will receive remimazolam before anesthesia, while the second will receive normal saline solution. the main outcome of the study will be the presence/absence of delirium during anesthesia recovery, while the secondary outcome will be the postoperative pain level, the length of stay in the recovery room, the presence of unwanted events in the recovery room, and the presence of postoperative mood changes.


Eligibility criteria:
inclusion criteria: * patients scheduled for rhinoplasty, rhinoseptoplasty or fess * asa i or ii exclusion criteria: * pregnancy * patients treated with psychiatric medication (in the time of operation or 6 months prior to operation)

Keywords: remimazolam
in hospital 24 hour observation of syncope patients

Conditions: Syncope

Summary: syncope is very common and has a broad differential diagnosis. guidelines on syncope recommend to apply guideline based syncope algorithm (sa) to identify low- / intermediate risk syncope patients and recommend to discharge these patients. the time window when to discharge these patients is not defined in the guidelines. in current medical practice low- / intermediate risk syncope patients are either immediately discharged or discharged after 24-hour observation with telemetry (tm). there seems to be an equipoise for both treatment strategies in current medical practice for these low risk syncope patients. a randomized controlled trial to compare discharge after 24 hour observation including tm with immediate discharge has never been done on the cardiac emergency room (cer).

the diagnosis of syncope is a worldwide clinical dilemma. appropriate identification of low risk vs high risk will reduce inappropriate admission for 24-hour observation with tm. the dutch geriatrics society prioritized syncope management on its research agenda. this project is endorsed by the dutch societies of neurology, cardiology, geriatrics, and internal medicine and results in freely accessible tutorials on an educational website: www.syncopedia.org. a randomized clinical trial that includes guideline based sa as routine medical care in the setting of a cardiac emergency room, that compares discharge after 24-hour observation with tm (reference treatment strategy) and immediate discharge (investigational treatment strategy) for low- and intermediate syncope patients will provide new insights and improve syncope health care for these patients.

Eligibility criteria:
inclusion criteria: all patients that are assessed as low- and intermediate risk syncope, are eligible for inclusion in this trial. the initial syncope evaluation includes: 1. complete and thorough history taking of the syncope event and past medical history 2. physical examination including supine and standing bp measurement and 3. 12 lead ecg. exclusion criteria: a potential patient who meets any of the following criteria will be excluded from participation in this study: 1. those aged \<18 years 2. those in whom syncope / transient loss of consciousness co-exist with trauma or other serious condition identified in the cer (massive bleeding, pulmonary embolus) or any high-risk features upon assessment with guideline based sa 3. those with any other conditions then syncope / transient loss of consciousness for which admission is required (including social indication for admission, etc.) 4. contraindication for early discharge as the discretion of the responsible physician 5. those with a learning disability 6. those presenting with pre-syncope 7. those who are unwilling to provide informed consent (those will be asked to be enrolled for the syncope r.i.s.c-registry)
do emotions affect mechanical pain thresholds?

Conditions: Pain

Summary: the purpose of this study is to investigate if different emotional states could influence mechanical pain thresholds.

participants will be randomized into 4 different groups watching different short video-clips (2.20 min). the negative emotions group will watch an uncomfortable short video containing violence and blood, the positive emotions group will watch a video containing a stand-up comedy show, the neutral emotions group will watch a video with swedish nature, and the control group will just wait for 2.20 min, without any instructions about what to think about. pressure pain thresholds will be measured with an algometer before and after the video-clip interventions.

Eligibility criteria:
inclusion criteria: * above 18 years of age, fluent in swedish. exclusion criteria: * pain anywhere in body during the test session, known neurological disease.
adult spinal deformity surgery real-world functional activity

Conditions: Degenerative Thoracolumbar Deformity

Summary: the purpose of this study is to measure functional activity and stability in spinal deformity patients utilizing motion analysis testing and accelerometers.


Eligibility criteria:
inclusion criteria: * diagnosis of degenerative thoracolumbar deformity * deformity correction surgery scheduled with either dr. elder or dr. fogelson, minimum 4-level fusion with fixation to the pelvis. exclusion criteria: ° unable to return to mayo clinic for follow-up evaluation
implementing evidence-based mental health practices in primary care

Conditions: Alcohol Consumption

Summary: this research study will examine the effectiveness of a brief, computerized motivational intervention plus treatment-as-usual to treatment-as-usual alone for treating alcohol misuse in veterans presenting to primary care. the investigators aim to recruit 162 veterans screening positive on the audit-c to participate in this study. participants will be randomly assigned to one of the two intervention conditions and be asked to complete a baseline assessment and two follow-up assessments conducted at three and six months post treatment. baseline assessments will be conducted in person by a trained research assistant, while all follow-up interviews will be conducted over the phone. the primary outcome for this clinical trial is the reduction in the number of heavy drinking days. several secondary outcomes will be collected including health status, depressive symptoms, consequences of drinking, pain symptoms, and distress tolerance. the findings from this study may have large scale implications for how alcohol misuse is treated in primary care. in addition, this study will provide evidence for the feasibility of using the computer as a method for delivering evidence-based mental health interventions in primary care.


Eligibility criteria:
inclusion criteria: * at least 18 years of age, * speak and read english, * u.s. veteran status, * screen positive on the audit-c exclusion criteria: * the presence of any cognitive difficulties that interfere with one's ability to consent to study participation

Keywords: alcohol consumption
clinical performance of nano fiber reinforced versus conventional nano hybrid composite in restoring premolars

Conditions: Clinical Performance

Summary: in patients that need composite restorations in a compound proximal carious lesions in premolars, will the clinical performance of nano fiber reinforced resin composite restorations have similar results compared to those restored with conventional nano hybrid resin composite over two years follow up period?

the study will be conducted in conservative dentistry department, faculty of dentistry, cairo university outpatient clinic. the operator in charge will be dr. the patients in this study will be selected according to different exclusion and inclusion criteria. teeth that meet the inclusion criteria will be selected (n=26) and divided into two groups (n=13). group (1): novaprotm fill universal composite (nanova columbia.mo. usa).group (2): tetric n-ceram nano-hybrid (ivoclarvivadent, schaan, liechtenstein). teeth will be cleaned to remove surface stains. compound proximal cavities will be prepared with rounded internal angles and with non beveled margins. the carious tissues will be removed using diamond burs of the suitable size at high speed under profuse water cooling system. after the cavity preparation and the appropriate shade of resin material selected, all restorations will be performed using a pre-curved metallic sectional matrix associated with a separating ring and a proper sized wooden wedge to establish the anatomical shape and proximal contacts of the teeth. all the restorative materials will be applied according to the manufacturer instructions (n=13) all participants will be instructed to follow oral hygiene measures (brush the teeth twice a day, floss once a day) to avoid plaque and bacterial accumulation which may negatively affect the performance. the restorations will be evaluated at baseline (after placement of restoration), after 6, 12, 18 \& 24 months, using modified united states public health service criteria (usphs) for the following characteristics: anatomic form (wear), marginal integrity, surface roughness, marginal discoloration, color match, recurrent caries, post-operative sensitivity. the resin composite restorations will be evaluated with the aid of a dental explorer and an intraoral mirror and visual inspection. the restorations will be scored as follows: alfa represents the ideal clinical situation, bravo will be clinically acceptable and charlie represents a clinically unacceptable situation.

Eligibility criteria:
inclusion criteria: * patient ages 18 to 55 years * male or female patients * patients with good oral hygiene * patients with good recall availability exclusion criteria: * patient who are allergic to products' ingredients used in the study * patients with poor oral hygiene * patients with history of bruxism and parafunctional habits * patients with high caries index or high plaque index. * pregnant or lactating women. * history of severe medical complications such as xerostomia