Kornimate/medical-research-clean huggingface dataset:
the effect of precede-proceed model based simulation experience in needlestick and sharps injuries among nurses

Conditions: Needlestick Injuries

Summary: healthcare workers are exposed to many important risks that will negatively affect their health in their working environment. among these risks, the most important threat is needlestick injuries. needlestick injuries in healthcare workers with work-related injuries among studies, and the prevalence of injury remains high. in a study conducted by gheshlagh et al. (2018), the prevalence of needlestick injuries in health workers was found to be 42.5%. it has been shown in studies conducted that the most common decision needlestick injuries among health workers are in nurses. in preventing injuries, preventing, and controlling negative behaviors related to the safe use of needlestick tools is among the most important strategies. in addition, the use of evidence obtained from interventional studies to prevent needlestick injuries in protection programs also plays an important role in prevention. the importance of frequent and regular education about the subject has been mentioned especially in the studies conducted to prevent injuries. the world health organization (who) has published gold standards in the education of nurses and has recommended the use of electronic learning and simulation methods in the programs of nursing schools for learning and teaching according to these standards. it is important to use evidence-based practices to increase quality and competence by creating realistic clinical environments in nursing education. in this context, it is possible to use simulation-based experiences for educational purposes without exposure to infection control and employee safety in the clinical field. in a study conducted by nakamura et al. (2019), it was found that a simulation-based training program was effective in infection control. due to the limited number of studies aimed at protecting the health of healthcare workers and controlling infection, more simulation-based studies are needed in this area. in addition, conducting model-based studies in developing behavior in health workers will also increase success. one of these models, the precede-process model, is an important guide for users in assessing the social, epidemiological, behavioral, and environmental spheres of society for planning and evaluating programs. in summary, the aim of the study is to evaluate the effect of the precede-process model-based simulation training program on preventing needlestick injuries in nurses who are the occupational group most exposed to injury.


Eligibility criteria:
inclusion criteria: * 0-1 years of experience in the profession, * nurses who volunteered to participate in the study, exclusion criteria: * nurses who graduated from acıbadem mehmet ali aydınlar university * nurses who have worked in the profession for more than one year

Keywords: needlestick injuries healthcare workers simulation precede-process model model based learning
impact of dmso concentrations on hematopoietic recovery after autologous hsc transplantation.

Conditions: Multiple Myeloma; Lymphomas; Leukemias

Summary: the main aim of the study was to evaluate the clinical impact of different dmso concentrations in cryopreservation mixture (5%, 7.5%, 10%) on reconstitution of hematopoiesis after autologous hematopoietic stem cell transplantation.

the procedure of autologous hematopoietic stem cell (hsc) transplantation requires cryopreservation of hscs. addition of dmso (dimethyl sulfoxide) is necessary to secure the viability of such cells, but this cryoprotectant is potentially toxic to stem cell recipient. the concentrations of dmso in cryopreservation mixture vary strongly between protocols in different transplant centers. usually, the hscs are stored in mixtures containing 10% dmso, but there is no sufficient evidence that this concentration of dmso is indeed optimal. the main aim of the study is to evaluate the clinical impact of reduction of dmso concentration in cryopreservation mixture on engraftment after autologous hematopoietic stem cell transplantation. 150 consecutive patients will be randomly assigned to one of three study arms (50 patients each). hscs obtained by leukapheresis will be cryopreserved in three concentrations of dmso: 5%, 7.5%, 10%, respectively. evaluation of the mixtures will be carried out by monitoring reconstitution of hematopoiesis and the frequency the side effects in patients. the most important aspect of our evaluation will be the speed of neutrophil recovery after transplantation (defined by the first day, when absolute neutrophil count in peripheral blood will be higher than 0.5 g/l). the investigators will also evaluate the toxicity of cell suspension by monitoring the frequency of infusion-related adverse events (like nausea or vomiting) during infusion and 24 hours after transplantation.

Eligibility criteria:
inclusion criteria: * patients with hematological malignancies or solid tumors, refered for autologous hsc transplantation * written informed consent

Keywords: dmso cryopreservation autologous transplantation hematopoietic stem cells hematological malignancies
bioequivalence study of bazedoxifene/conjugated estrogen tablets in postmenopausal women

Conditions: Menopause

Summary: the primary objective is to evaluate the bioequivalence between bazedoxifene/conjugated estrogens tablets produced using the current manufacturing process to bazedoxifene/conjugated estrogens tablets produced using a new manufacturing process


Eligibility criteria:
inclusion criteria * healthy, postmenopausal women aged 35 to 70 years and weighing at least 50 kg (approx. 110 lbs). * at least 6 months of spontaneous amenorrhea (with follicle-stimulating hormone levels of 39 miu/ml or greater). * nonsmoker or smoker of fewer than 10 cigarettes per day, with ability to abstain for 5 days. exclusion criteria * women with amenorrhea starting after 54 years of age. * a history or active presence of clinically important medical diseases. * use of oral estrogen-, progestin, androgen-, or serm-containing drug products within 30 days before receiving study drug.
measurements of facial dimensions in infants and toddlers 0-4 years of age

Conditions: Infant Development

Summary: anthropometric data of infants' face will be obtained using special 3d scanners and software.

a digital camera will be used to take a 3d picture the face of each infant. off line measurements of landmarks on the face will be marked and dimensions will be calculated using a special analysis software.

Eligibility criteria:
inclusion criteria: * healthy infants, 0-4 years of age exclusion criteria: * facial anomalies

Keywords: infants morphometry face 3d
effect of fermented ginseng (ginst) on sperm motility

Conditions: Asthenozoospermia

Summary: this randomized, double-blind, placebo-controlled study aimed to evaluate the effect of ginseng(ginst) supplementation for 12 weeks on sperm motility.

this multicenter, randomized, double-blind, placebo-controlled clinical trial was aimed to evaluate of sperm motility improvement effect of fermented ginseng(ginst). experimental arm and control arm were randomly assigned among the volunteers who met the inclusion criteria: men between the ages of 18 and 60 who had sperm motility of less than 32%. to experimental arm, capsules including 160mg of fermented ginseng(ginst) ingredients will be provided for 12 weeks. to control arm, capsules of the same shape and weight as ginst capsules will be provided. these capsules are made of a cellulose component. primary outcome is sperm motility. secondary outcome are \ , \ , and \ measured at baseline and end of the trial.

Eligibility criteria:
inclusion criteria: * male between 18 and 60 years old * men who have agreed to participate in this trial before the start of the study and who have written an informed consent exclusion criteria: * those who are diagnosed and treated for hypertension (systolic blood pressure\> 140mmhg and diastolic blood pressure\> 90mmhg) * patients with a history of chemotherapy for malignant tumors * patients with a history of taking testosterone or antiandrogens within 1 month * bmi\> 30 or bmi \<18 * those who have the following results in the blood test: ast(aspartate aminotransferase ), alt(alanine transaminase) \> 2 times the upper limit of reference range; serum creatinine\> 2.0 mg / dl * those who ingested drugs (eg, folic acid, l-carn, hcg(human chorionic gonadotropin ), fsh(follicle-stimulating hormone), clomiphene, etc.) that have an effect on sperm motility within 2 weeks before the screening day. * persons who have received antipsychotic medication within 2 months before the screening test * those who have history of alcoholism or substance abuse
home-based circuit training for people with intermittent claudication

Conditions: Peripheral Artery Disease; Intermittent Claudication

Summary: the purpose of the study is to assess the feasibility of undertaking a randomised controlled trial investigating the effectiveness of a 12-week home-based exercise programme for people with intermittent claudication.

30 participants with pad will be randomised to one of two groups: either exercise or usual care. the 12 week exercise intervention will consist of a home-based circuit programme, including both resistance exercises and walking. this will be combined with promoting free-living walking throughout the rest of the week. exercise will be regulated via the use of a wearable activity monitor. biweekly phone calls will address compliance with the intervention. the primary outcomes are feasibility and acceptability, which will be determined after 12 weeks via recruitment and attrition rates, protocol adherence and with participant interviews. secondary outcomes include changes in pain-free and maximal walking distances with both a graded treadmill test and six-minute walk test, hand grip strength, physical activity behaviour (measured with an accelerometer), quality of life (measured with the sf-36, vascuqol and e5-5d-5l questionnaires) after 12 and 24 weeks. investigators will also assess changes in markers of inflammation, vascular remodeling, mitochondrial biogenesis and oxidative stress at 12 and 24 weeks. other outcomes include changes in time spent resting during a six-minute walk test and time to pain cessation following a graded treadmill test at 12 and 24 weeks.

Eligibility criteria:
inclusion criteria: * ankle/brachial index (abpi) \< 0.9 at rest or a drop of 20mmhg after exercise testing * ability to walk independently * english speaking * able to follow instructions * ≥ 18 years of age exclusion criteria: * unable to provide informed consent * walking impairment for a reason that is not pad * critical limb ischaemia * asymptomatic pad * active cancer treatment * severe mental or physical limitations precluding participation safely in the home environment

Keywords: home-based exercise circuit training walking
ramosetron versus ondansetron for radiotherapy induced nausea and vomiting

Conditions: Radiotherapy Induced Nausea and Vomiting

Summary: the purpose of this study is: 1. to compare prophylactic effect of ondansetron versus ramosetron on radiotherapy induced nausea and vomiting in the treatment of gastrointestinal cancer. 2. to verify an improvement of 20% in complete response rate in term of radiotherapy induced nausea and vomiting (from 60% with ondansetron to 80% with ramosetron).


Eligibility criteria:
inclusion criteria: * ajcc 1-3 staged gastrointestinal cancer patient * patient undergoing radiotherapy as treatment * age 20 yr and higher * ecog 0-2 exclusion criteria: * age \< 20 * ecog 3-4 * patient experiencing nausea or vomiting prior to accrual * patient under antiemetic medication * patient under steroid medication (topical or inhalant steroid application are exceptional) * patient under opioid medication
effectiveness of video-based rehabilitation program on pain, functionality and quality of life in the treatment of rotator cuff tears

Conditions: Rotator Cuff Tear; Pain, Shoulder

Summary: the aim of this study was to investigate the efficacy of the video-based rehabilitation program on pain, functionality and quality of life in the conservative treatment of partial tears of the rotator cuff whether it was as successful as the physiotherapist-supervised rehabilitation program.

in our study a common exercise program, which can be used in conservative treatment of a partial rotator cuff tear, is applied with two different methods; a video-based rehabilitation program and physiotherapist-supervised rehabilitation program. video-based rehabilitation program was developed to investigate whether this program is effective on pain, functionality and quality of life and as successful as a physiotherapist-supervised rehabilitation program.

Eligibility criteria:
inclusion criteria: * forty years of age or older patients that had been diagnosed for a partial rotator cuff tear that was unrelated to trauma by a specialist orthopedist with mri and physical examination and no other shoulder problems on the diagnosed shoulder were included into this study. exclusion criteria: * patients that had been diagnosed for a full-thickness or massive rotator cuff tear, operated previously, had frozen shoulder or glenohumeral instability * younger than 40-year-old, and athletic patients with acute tear symptom were excluded from this study.

Keywords: rotator cuff physiotherapy video-based rehabilitation exercise
treatment of sacroiliac dysfunction with si-lok® sacroiliac joint fixation si-si-lok

Conditions: Joint Dysfunction

Summary: the objective of this study is to gather clinical data on si-lok® for the treatment of sacroiliac joint dysfunction. the purpose of this prospective study is to evaluate clinical and radiographic outcomes, intra-operative parameters, patient satisfaction and work status following a procedure using si-lok® for treatment of sacroiliac joint dysfunction with a minimum of three screws.

clinical research forms will be completed at all pre-op, intra-op and post-op visits by either the surgeon, clinical coordinator or patient. forms completed by patients will be checked, initialed and dated by the site coordinator. data collected will be presented as mean +/- standard deviation. statistical significance will be evaluated at the p \< 0.05 significance level.

Eligibility criteria:
inclusion criteria: * a maximum age of 70 years * diagnosis of sij dysfunction * ability to provide informed consent for study participation and to return for all follow-up visits exclusion criteria: * previous documentation of osteopenia or osteomalacia * history of metabolic bone disease (e.g. diabetes requiring daily insulin) * diagnosis of a condition or requires postoperative medication(s), which may interfere with bony/soft tissue healing * presence of a disease entity or condition which totally precludes possibility of bony fusion (e.g. metastatic cancer, hiv, long term use of steroids, etc.) * history of substance abuse (drugs or alcohol) * condition that would preclude completing patient self assessment questionnaires * mentally incompetent or prisoner * currently a participant in another study

Keywords: sacro-iliac joint
a clinical trial to study the feasibility and acceptability of an app to support pediatric resuscitation

Conditions: Pediatric Emergency Medicine; Resuscitation; Pediatrics; Emergency Medical Services; Arrest Cardio Respiratory

Summary: the goal of this clinicial trial is to test the acceptability and feasibility of linear cognitive aid intervention to support ems teams in responding to pediatric emergencies. we are testing the hypothesis that cognitive aids with linear logic will be feasible to use and acceptable to ems teams in urban and rural areas. researchers will compare technical performance, teamwork, and self-assessed cognitive load of participants to see the difference between performing resuscitations using their current standard with existing cognitive aids and using our linear cognitive aid. participants' teams will: * perform in situ high-fidelity simulation of two critical children's resuscitation scenarios * be randomized to 1) perform both resuscitations with their current standard with existing cognitive aids or 2) perform both resuscitations using our linear cognitive aid.


Eligibility criteria:
inclusion criteria: * active public, private, volunteer, hospital-based, or third-party ems providers * speaks and understands english * age 18 and over exclusion criteria: - not clinically active

Keywords: pediatric emergency medical services rural-urban health disparities child mortality adverse safety events (ases) prehospital pediatric care cognitive aid randomized controlled trial (rct) emergency resuscitation out of hospital cardiac arrest
soothe versus refresh

Conditions: Dry Eye Syndromes

Summary: to determine the ocular efficacy and safety of soothe and refresh tears.


Eligibility criteria:
inclusion criteria: * adults with a diagnosis of dry eyes * schirmer's with anesthesia grade between 1-7 mm inclusive after five (5) minutes in at least one eye * a corneal staining grade of greater than or equal to 2 (scale 0-4) in the same qualifying eye as the schirmer's test exclusion criteria: * contact lens use during the active treatment periods of the trial * history of sjogren's syndrome * temporary punctal occlusion that is still effective * the current or anticipated use during the study of punctual plugs * current treatment with restasis
migraine and endothelial dysfunction

Conditions: Migraine With Aura

Summary: recently, there is evidence that endothelial activation and dysfunction are associated with migraine, especially in female migraineurs with aura. our objectives were to determine whether novel endothelial function markers are altered in female migraineurs with aura compared to age-matched controls.

our objectives were to determine whether novel endothelial function methods and novel markers of endothelial activation are associated with migraine in female migraineurs with aura. migraine is an independent risk factor for stroke, especially in young women with aura symptoms. endothelial dysfunction is a risk factor for cardiovascular diseases. recent studies suggest that there is a link between migraine with aura and endothelial activation, dysfunction and impaired vascular reactivity. in this case-control study the investigators examine several novel biomarkers of endothelial function such as endothelial progenitor cells and endothelial microparticles as well as novel methods such as reactive hyperemic peripheral arterial tonometry in female migraineurs with aura and age-matched controls.

Eligibility criteria:
inclusion criteria: * migraine with aura * age \< 50 * female gender exclusion criteria: * severe infectious disease * cardiovascular disease (stroke, coronary heart disease, myocardial infarction) * vasculitis * peripheral artery disease * diabetes mellitus * pregnancy * drug abuse * medication: statin, anticoagulation, aspirin, clopidogrel * intake of triptans \<24h

Keywords: migraine with aura
drug-eluting stents vs. drug-coated balloon for preventing recurrent in-stent restenosis

Conditions: Coronary Restenosis

Summary: the purpose of this study is to establish the safety and effectiveness of paclitaxel eluting balloon (sequent please) compared to coronary stenting with the everolimus-eluting balloon expandable stent (xience prime or xience xpedition or xience alpine) in the treatment of drug eluting stent restenosis.


Eligibility criteria:
inclusion criteria: * the patient must be more than or equal to 20 years of age * restenosis after drug-eluting stents (\>50% by visual estimate) * any lesion length including focal in stent restenosis or diffuse in stent restenosis * the patient or guardian agrees to the study protocol and the schedule of clinical and angiographic follow-up, and provides informed, written consent, as approved by the appropriate institutional review board/ethical committee of the respective clinical site. exclusion criteria: * the patient has a known hypersensitivity or contraindication to any of the following medications: * heparin * aspirin * both clopidogrel and ticlopidine * sirolimus eluting stent * stainless steel and/or * contrast media (patients with documented sensitivity to contrast which can be effectively pre-medicated with steroids and diphenhydramine \[e.g. rash\] may be enrolled. patients with true anaphylaxis to prior contrast media, however, should not be enrolled) * systemic (intravenous) everolimus use within 12 months. * female of childbearing potential, unless a recent pregnancy test is negative, who possibly plan to become pregnant any time after enrollment into this study * non-cardiac co-morbid conditions are present with life expectancy \<1 year or that may result in protocol non-compliance (per site investigator's medical judgment) * patients who are actively participating in another drug or device investigational study, which have not completed the primary endpoint follow-up period

Keywords: drug-eluting stent drug-coated balloon recurrent in-stent restenosis
feasibility, safety and effectivity of an exercise intervention for newly diagnosed multiple myeloma patients during induction therapy

Conditions: Multiple Myeloma Bone Lesions

Summary: physical exercise is an important supportive therapy for cancer patients, which improves quality of life and can effectively counteract the side effects of drug therapy. there is very little experience whether physical activity can also be performed safely by patients with malignant diseases that affect bone stability. this applies in particular to patients with multiple myeloma, a disease characterized by a monoclonal proliferation of plasma cells in the bone marrow and often accompanied by severe bony destruction. aim of this exploratory randomized controlled trial is to evaluate feasibility, safety and effectivity of an orthopaedic-guided exercise intervention during induction therapy in newly diagnosed multiple myeloma patients.


Eligibility criteria:
inclusion criteria: * newly diagnosed multiple myeloma * survival prognosis \> 6 months * ecog status ≤ 3 * age ≥18 years * patients who state that they want to carry out the training program at least 2 x/week and participate in the planned follow-up visits * ability to give informed consent * written consent to participate in the study * sufficient knowledge of written and spoken german exclusion criteria: * physical or mental limitation that would prevent participation in the training program or the planned follow-up visits. * carrying out a regular, intensive training program (min. 1h, 2x/week)

Keywords: orthopaedic evaluation of bone stability multiple myeloma physical exercise osteolysis