Kornimate/medical-research-clean huggingface dataset:
screening for covid-19 and monitoring of serological responses to sars-cov-2 in healthcare workers

Conditions: SARS-CoV-2

Summary: the main objectives of this study are 1) to establish the prevalence of sars-cov-2 in asymptomatic healthcare workers (hcws) in an early phase of community spread as well as 2) to monitor the future spread of the disease by assessing serological responses to sars-cov-2 in symptomatic and asymptomatic hcws over time and 3) to improve the assessment of the immune response and its protective effect as well as the assessment of infectivity of affected hcws and 4) to evaluate the value and significance of antibody formation and serological antibody tests and 5) to be able to evaluate possible future preventive and / or therapeutic approaches against sars-cov-2, e.g. to assess vaccination effects

this study aims to collect information on staff working at the greifswald university hospital. over a 5 year period, a maximum of 12 study visits per participant are planned. at each visit, nasal/throat swabs (for pcr testing) and/or blood samples (to assess immunological responses, e.g. for sars-cov-2 antibody testing) will be collected. this will help to gain a better understanding of viral load and immunological responses, e.g. antibody development and their effects over time. at study visit 2 - 12, participants will also be asked to fill in a questionnaire (asking for sars-cov-2 risk factors, perceived risk, impact of the pandemic on their quality of life, their interest in getting a sars-cov-2 vaccine/their sars-cov-2 vaccination status and vaccination side effects). the remaining blood samples will be stored in a repository for future research. the study is part of a modular sars-cov-2-research programme of the university medicine greifswald.

Eligibility criteria:
inclusion criteria: 1. \>= 18 years of age 2. willing and able to complete a written consent form 3. willing to have blood samples stored for future research 4. healthcare worker employed at greifswald university hospital exclusion criteria: 1. \< 18 years of age 2. decline to participate

Keywords: serology antibody formation epidemiology immunity
study: effects of strawberries on blood pressure

Conditions: Pre-hypertension

Summary: the specific aim of the study is to determine whether a freeze dried powder provided by the california strawberries commission, can reduce blood pressure in patients with pre-hypertension. the powder is prepared by the california strawberry commission (csc).

primarily, we would like to find out whether freeze dried strawberry powder lowers blood pressure. in addition we would like to know if the strawberry alters the subject's blood cholesterol and the ability of the subject's blood vessels to relax.

Eligibility criteria:
inclusion criteria: * pre-hypertensive men and women (jnc 7 \[the seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure\] criteria) between the ages of 25 and 65 years who have no clinical evidence/history of cardiovascular, respiratory, renal, gastrointestinal or hepatic disease. exclusion criteria: * subjects who: 1. are taking over the counter anti-oxidant supplements, 2. are taking prescription medications that may interfere with study procedures or endpoints, 3. have unusual dietary habits (eg., pica), 4. are actively losing weight or trying to lose weight, 5. are addicted to drugs or alcohol, 6. present with significant psychiatric or neurological disturbances, 7. have known allergies to strawberry, will be excluded from participating in this study. 8. patients known to have glaucoma 9. pregnant and/or lactating females

Keywords: blood pressure strawberry fruit phenolics ldl oxidation flow mediated dilation (fmd)
safe pregnancy by infectious disease control

Conditions: Pregnancy; Malaria

Summary: malaria and sexually transmitted infections (stis) are common in pregnant women in africa and are important preventable causes of poor birth outcomes and maternal and infant mortality. this study investigated baseline characteristics of the population including: rates of stis including hiv, prevalence of malaria and tuberculosis (tb) and resistance to common antimalarial drugs.

a cross-sectional observational study was conducted with 2008 pregnant women attending either binza or kingasani maternity clinics in kinshasa, drc to determine baseline rates of stis, tb and malaria. data was collected for sample size calculation in a larger sti/malaria and tb randomized controlled trial.

Eligibility criteria:
inclusion criteria: * older than or equal to 15 years of age * pregnant * presenting for antenatal care at one of the two target maternities for the first time during the current pregnancy * willing to provide informed consent exclusion criteria: * refusal to participate in the hiv voluntary and counseling program at the maternity center or refusal to share hiv results with the study staff.

Keywords: infectious diseases democratic republic of congo malaria international maternal and child health women's health global network sexually transmitted infections (stis)
pilot study using a pet gamma probe to evaluate lymph nodes in endometrial cancer

Conditions: Endometrial Cancer

Summary: the surgical management of high-risk endometrial cancer often involves an extensive operation to remove lymph nodes as sites of possible cancer spread. 18f-fdg pet/ct imaging is increasingly being used to identify sites of cancer spread and recently groups have used an intra-operative gamma probe to better localize metastatic disease. in this pilot study, patients with newly diagnosed early stage, high-risk endometrial cancer undergoing primary surgery will have a pre-operative pet scan and intra-operative localization of metastatic lymph nodes with the use of a gamma probe. a complete lymphadenectomy will follow and ability to detect positive lymph nodes of both pet scan and the intra-operative probe will be calculated. this study addresses the feasibility of an fdg detection gamma probe in addition to a pre-operative pet/ct for lymphatic mapping in women with clinical early stage high risk endometrial cancer. the study will also evaluate the role of identifying metastatic lymph nodes intraoperatively that would otherwise be clinically negative.


Eligibility criteria:
inclusion criteria: * women with adenocarcinoma of the endometrium with one of the following subtypes: * serous * clear cell * carcinosarcoma (mmmt) * high grade endometrioid * clinical stage 1 or 2 * patients who have signed an approved informed consent. * patients who will undergo surgery that includes a hysterectomy and/or hysterectomy, bilateral salpingo-oophorectomy, bilateral pelvic and para-aortic lymph node exclusion criteria: * patients with previous retroperitoneal surgery * patients with previous history of pelvic/abdominal radiation * any patient treated with neoadjuvant chemotherapy and/or radiation

Keywords: early high risk
anxiety and distress levels in women with suspected endometrial cancer

Conditions: Endometrial Cancer; Cancer; Uterine Cancer; Anxiety; Stress; Psychological

Summary: patients attending the rapid access gynaecology clinic with a suspicion of endometrial cancer are understandably nervous. few studies have quantified anxiety and distress of patients in this group. this study surveys anxiety and stress levels of women attending clinic (by filling in an anonymous questionnaire). additionally, in women who need a tissue biopsy, women are asked to rate their pain scores.

aims: quantify the anxiety and stress levels of women attending the rapid access gynaecology clinic with a suspicion of cancer background: endometrial cancer is a tumour originating in the endometrium (womb lining); it is the most common gynaecological cancer in the united kingdom (uk). in 2012, there were almost 100,000 new cases diagnosed in europe. endometrial cancer classically presents with postmenopausal bleeding (bleeding after the menopause), or intermenstrual bleeding (bleeding in between periods). although routine management for these women does vary, in general a screening test is performed, typically a pelvic (internal) ultrasound to assess the endometrium (womb lining). in cases where the endometrial thickness is above the threshold for investigation -an endometrial biopsy (sampling cells from the womb lining) is indicated. whilst well tolerated, this can be quite painful. once the endometrial biopsy is performed, it is sent to the histologist for further examination. histological analysis may take several days and patients are either brought back to clinic for discussion of the results or are given a telephone appointment. the patient often will not know the result of the test for up to 2 weeks; thus causing a lot of unnecessary anxiety and distress. the study: patients attending the rapid access gynaecology clinic will be invited to participate in the study by filling in a short anonymous survey. additionally, patients undergoing a tissue biopsy sample will be asked to provide a pain score, followed by a brief interview to ascertain if they would undergo the procedure again if it was needed and how they tolerated the procedure. additionally, the time taken to perform the procedure will be recorded.

Eligibility criteria:
inclusion criteria: * all women presenting to rapid access gynaecology clinic with suspected gynaecological cancer exclusion criteria: * anyone lacking capacity. * \<18years old. * pregnant. * anyone unable to understand english (in absence of translator)

Keywords: endometrial cancer cancer uterine cancer anxiety stress psychological survey point-of-care
a study evaluating sta-9090 in patients with metastatic and/or unresectable gastrointestinal stromal tumor (gist)

Conditions: Gastrointestinal Stromal Tumor

Summary: the purpose of this study is to determine if sta-9090 is effective in the treatment of patients with metastatic and/or unresectable gist.

planned: * stage 1: 23 patients. if ≥4 patients had clinical benefit, an additional 32 patients were to be enrolled. up to 3 additional patients with platelet-derived growth factor receptor, alpha polypeptide (pdgfra) mutation were to be enrolled, regardless of the total study enrollment. * stage 2: 55 patients. progressing to this stage was dependent on stage 1 results. analyzed: * stage 1: 27 patients were enrolled and analyzed. the study was not expanded to stage 2 due to insufficient efficacy.

Eligibility criteria:
inclusion criteria: * must be at least 18 years of age at the time of study entry * must have histologically confirmed metastatic and/or unresectable gist * must have measurable disease on computed tomography or magnetic resonance imaging as defined by response evaluation criteria in solid tumors (recist) * must have documented failure (due to either progression or intolerance)of at least prior imatinib and sunitinib. previous administration of other known heat shock protein 90 (hsp90) inhibitors is permitted * eastern cooperative oncology group (ecog) performance status 0 or 1 * must have acceptable laboratory values as defined in the protocol exclusion criteria: * known central nervous system metastases * major surgery within 4 weeks prior to receiving sta-9090 * use of any investigational agents within 2 weeks or 6 half-lives of the agent, whichever is shorter prior to receiving sta-9090 * no treatment with chronic immunosuppressants * must have otherwise adequate health status as defined in the protocol * left ventricular ejection fraction (lvef) \< than or = 50% at baseline * baseline corrected qt interval (qtc) \> 470 msec * pregnant or lactating females

Keywords: g.i. stromal tumor gist
the healthcare evaluation of absolute risk testing study

Conditions: Cardiovascular Diseases

Summary: the aim of this study is to demonstrate the integration and use of cardiovascular disease (cvd) integrated risk tool (irt) in an environment as close to real-world as possible. this study will recruit participants of both biological sexes and any ancestry or background who require and are eligible for a cvd risk assessment as part of the nhs health check. those aged 45-64 years are most likely to benefit from cvd irt and will be included in the study, as they are more likely to be asymptomatic but also derive most benefit from preventative measures. the study will be conducted in gp surgeries as the cvd irt will have its greatest impact if incorporated into primary care practice for early identification of patients at highest risk. this study is a device performance evaluation.

the aim of this study is to demonstrate the integration and use of a cardiovascular disease (cvd) integrated risk tool (irt) in an environment as close to real-world as possible. in association with the routine healthchecks for cvd, the qrisk score will be integrated with the individuals polygenic risk score (from a blood sample) to produce the cvd irt score, this score estimates the risk of cvd in the following 10years. this study will recruit participants of both biological sexes and any ancestry or background who require and are eligible for a cvd risk assessment as part of the nhs health check. those aged 45-64 years are most likely to benefit from cvd irt and will be included in the study, as they are more likely to be asymptomatic but also derive most benefit from preventative measures. the study will be conducted in gp surgeries as the cvd irt will have its greatest impact if incorporated into primary care practice for early identification of patients at highest risk. this study is a device performance evaluation. 1000 participants are expected to be enrolled. of this, it is expected that 200 surveys will be completed and from those surveyed 20-30 interviewed. this would be considered an adequate determination of feasibility.

Eligibility criteria:
inclusion criteria: * able and willing to provide written informed consent and to comply with the study protocol * either male or female (biological sex) * aged 45-64 years (inclusive) * any ancestry or background * eligible for nhs health check using qrisk®2 assessment exclusion criteria: * those excluded from nhs health checks; * currently prescribed and taking hmg-coa reductase inhibitors (lipid-lowering preventive treatments or statins) for any indication.
cervical cancer screening in hiv positive and negative women in cambodia

Conditions: Cervical Neoplasia; Cervical Cancer

Summary: the prevalence of cervical neoplasia in cambodia is not known. there are no screening programs in place. the investigators plan on introducing a screening program based on who criteria and utilizing visualization with acetic acid. patients who are positive will be offered same-day cryotherapy if indicated or will be referred for biopsy, leep and hysterectomy as indicated. the planned patient pool for this study is 1000 women, half of whom will be hiv positive (and thus have a presumed higher incidence of cervical neoplasia).


Eligibility criteria:
inclusion criteria: * female, age 30-49, able to give informed consent exclusion criteria: * pregnancy, gross cervical mass, prior cervical cancer, unable to give informed consent, prior complete hysterectomy, allergic to acetic acid

Keywords: cervical neoplasia cervical cancer' visual inspection acetic acid cryotherapy
the impact of sleep-disordered breathing on the incidence of postoperative acute kidney injury in patients undergoing valvular heart surgery

Conditions: Valvular Heart Disease

Summary: sleep-disordered breathing has a prevalence of 30\~80% in patients with heart diseases. various studies have revealed a correlation between the incidence and various diseases such as heart failure, hypertension, diabetes, and cerebral infarction. postoperative acute kidney injury after heart surgery is one of the major complications with incidence with 40\~50%, however, there has been no preventive method or treatment yet. recently, several studies have been published that have shown a correlation between sleep-disordered breathing and renal impairment. in general, sleep-disordered breathing can be regulated easily with continues positive expiratory pressure, which means that early diagnosis and treatment of sleep-disordered breathing might help to reduce the incidence of postoperative acute kidney injury and improve patients' prognosis. in this study, the investigators investigate the impact of sleep-disordered breathing (diagnosed by oxygen desaturation index ≥5) on the incidence of postoperative acute kidney injury in patients undergoing valvular heart surgery.


Eligibility criteria:
inclusion criteria: 1. adult patient aged more than 20 years 2. patients undergoing valvular heart surgery. exclusion criteria: 1. emergency 2. simultaneous surgery with coronary artery bypass graft 3. previous history of cerebrovascular accident 4. previous history of sleep disordered breathing (diagnosis \& treatment) 5. previous history of tracheostomy 6. previous history of surgical treatment of airway (ex: nasopharyngeal cancer) 7. preoperative oxygen supplement therapy 8. patients who have participated in other clinical studies that may affect prognosis 9. patients who cannot read and agree to informed consent (ex: foreigners, cognitive dysfunction)

Keywords: valvular heart surgery cardiopulmonary bypass
partial implant-supported rehabilitation using peek

Conditions: Prosthesis Survival

Summary: the goal of this observational study is to evaluate the outcome of a poly-ether-ether-ketone - used in partial implant-supported rehabilitations after one year of follow-up. the main question it aims to answer is: - what is the survival outcome of partial implant-supported prosthesis using poly-ether-ether-ketone? the participants already rehabilitated with dental implants will receive a definitive 3 unit prosthesis incorporating poly-ether-ehter-ketone.

following the previous study on the full-arch rehabilitation of edentulous jaws using hybrid prostheses with polyetheretherketone (peek) infrastructure and acrylic resin teeth supported by implants in immediate function inserted through the all-on-4 concept it is necessary to further extend the evaluation to the partial rehabilitation using 3 unit fixed prostheses supported by dental implants. to test this, the study design to be used will be a single-centre, prospective, observational cohort study to evaluate the short term outcome of fixed prosthetic implant-supported rehabilitations. the sample of this study consists in 10 patients consecutively treated. the cohort will be evaluated at 4 to 8 weeks, 6 months and 12 months after dental loading and annually thereafter as long as the patient is willing, regarding: prosthetic survival including repair and relining, implant survival, marginal bone resorption, incidence of mechanical complications \[loosening or fracture of prosthetic components), biological complications (peri-implant infection, suppuration, abscess, fistulae), patient tissue reaction, aesthetic examination including denture staining, colour stability and anatomic form; patients' in-mouth comfort and quality of life using the oral health impact profile ohip-14 questionnaire; and assessment of prosthetic preparation (technician satisfaction), laboratory preparation time, clinical operative time and costs.

Eligibility criteria:
inclusion criteria: * patients rehabilitated with dental implants and a 3 unit bridge where the molars are missing in one jaw, with at least both canines present; * subjects who, in the opinion of the investigator, are able to understand this clinical study, co-operate with the procedures and are willing to return to the clinic for all the required post-operative follow-ups; * subjects who are able to give voluntary, written informed consent to participate in this clinical study and from whom consent has been obtained. exclusion criteria: * female subjects who are pregnant; * subjects who are known drug or alcohol abusers or with psychological disorders that could affect follow-ups or treatment outcomes; * subjects who are currently enrolled in a clinical study; * subjects requiring or currently having ongoing orthodontic treatment.

Keywords: prosthesis dental implants peek
photodynamic therapy for the treatment of chronic rhinosinusitis

Conditions: Chronic Sinusitis

Summary: the purpose of this study is to determine whether the use of light and a topically applied photosensitizer can relieve symptoms and clinically improve patients with chronic rhinosinusitis.

this clinical trial will be a prospective, randomized, single-center study utilizing two treatment assignments and a control group. the study is expected to enroll a total of 48 subjects. the intent of the study is to evaluate a single versus double treatment of photodisinfection in men and women suffering from chronic persistent rhinosinusitis with and without nasal polyposis. each photodisinfection treatment group will be compared to a control group receiving saline irrigation.

Eligibility criteria:
inclusion criteria: * history of chronic rhinosinusitis with and without nasal polyposis * no antibiotics within 4 weeks * no oral steroid use within 4 weeks * no topical steroid use within 2 weeks * endoscopic sinus surgery greater than 6 months previously exclusion criteria: * acute respiratory infection within last 2 weeks * septal deviation restricting sinus access * known allergy to methylene blue * pregnant or breast feeding

Keywords: chronic rhinosinusitis sinusitis photodisinfection photodynamic therapy antimicrobial photodynamic therapy apdt pdt paranasal sinus diseases respiratory tract infections respiratory tract diseases
cervical ripening before endometrial biopsy in abnormal uterine bleeding using sublingual misoprostol

Conditions: Abnormal Uterine Bleeding Unrelated to Menstrual Cycle

Summary: abnormal uterine bleeding is common in thai women. fractional curettage is an diagnostic procedure of this condition. traditionally, fractional curettage is performed under local anesthesia such as paracervical nerve block or intravenous meperidine. cervical dilatation using "metal cervical dilator" is a common method prior to perform fractional curettage. however, complication from this procedure can be occurred frequently, for example, uterine perforation, false tract formation and laceration of cervix. misoprostol is a prostaglandin e1 analogue which is commonly used in obstetrics and gynecology. misoprostol transforms cervical component causing cervical ripening. this is very helpful for transcervical procedure because cervical dilatation is usually omitted. it can be prescribed in many route and sublingual route is the most effectiveness. moreover, who supports the use of misoprostol in obstetrics and gynecology practice. the hypothesis of this study is that "misoprostol 200 micrograms sublingually is effective for cervical ripening before performing fractional curettage in patients with abnormal uterine bleeding" double blind randomised controlled trial was performed using 26 patients in each group.


Eligibility criteria:
inclusion criteria: * thai women at the age over 35 years old * presenting with abnormal uterine bleeding and have a plan to perform fractional curettage exclusion criteria: * uterine anomalies * pregnancy * pelvic inflammatory disease * uncontrolled medical or psychological conditions * known cases of gynecological diseases such as gynecological malignancies, abnormal pap smear * prostaglandin allergy * contraindicate to prostaglandin: asthma, mitral valve stenosis, glaucoma, sickle cell anemia