Kornimate/medical-research-clean huggingface dataset:
neuromodulation in lateral elbow pain

Conditions: Lateral Epicondylitis

Summary: lateral epicondylitis (le), also known as tennis elbow, refers to a painful condition at or around the lateral epicondyle of the humerus and common extensor tendon (cet) that is aggravated by dorsiflexion and/or supination of the wrist against resistance. lateral epicondylitis is one of the most common injuries of the elbow, affecting 1-3% of the population. therefore, determining an effective intervention that helps manage the condition and lessens the financial burden is important. passive physical modalities, including electrotherapy and orthotic devices, are common treatments for the management of elbow pain. passive physical modalities are physical treatments involving a device that does not require active participation by the patient. in a systematic review, 2017, dion et al examined the effectiveness of passive physical modalities for the treatment of soft tissue injuries of the elbow, but little evidence exists to support or refute their use. clinically, an invasive technique has appeared, known as ultrasound-guided percutaneous neuromodulation (pnm). this minimally invasive intervention consists in the applicacion of a percutaneous electrical stimulation (pes) through an acupuncture needle-like electrode that is placed in close proximity to the nerve or motor point of the muscle with ultrasound guidance. at the clinical level, the pes is always used with the therapeutic aim of relieving chronic pain and neuropathic pain. similarly, in sports, pes is used with the aim of improving muscular activity. therefore, according to the characteristics and the therapeutic benefits of this technique, further research is needed to discover multiple clinical indications. the aim of this pilot study was to examine the effects of a percutaneous neuromodulation intervention in patients with unilateral refractory lateral epicondylitis. findings from this study may provide further evidence for the relevance of neural tissues in determining the elbow pain and may indicate effects of us-guided nmp technique on the rehabilitation and/or prevention of in patients with unilateral refractory le.


Eligibility criteria:
inclusion criteria: * presence of pain in the elbow region at least for three months * flares with activity * tenderness at or within 2cm of the lateral humeral epicondyle on resisted extension of the wrist and/or the third finger. exclusion criteria: * participants who had constant or radicular pain * any previous surgery or acute trauma in the upper extremity. * elbow deformity * bilateral symptoms * clinical or electrophysiological findings referable to peripheral nerve (ulnar and median) disease and

Keywords: percutaneous neuromodulation, radial nerve, pain
native-rise (risk identification for suicide and enhanced care)

Conditions: Suicide Prevention

Summary: the goal of this research is to test a systems-level suicide prevention strategy, native-rise (risk identification for suicide and enhanced care), that combines predictive analytics and brief contact interventions (bcis) to reduce suicide in health systems serving native americans (nas). this project aims to prove the effectiveness and scalability of native-rise within three indian health service (ihs) health care clinics (whiteriver, chinle and shiprock) already implementing suicide prevention programs and serving the white mountain apache tribe (wmat) and navajo nation (nn).


Eligibility criteria:
inclusion criteria: * adults aged 18-75 * visit at least one of the three participating ihs clinics * identified as at risk of suicide by either an existing method or the new native-rise risk model algorithm exclusion criteria: * none
multi-center 2-week clinical evaluation of three silicone hydrogel contact lenses

Conditions: Myopia

Summary: the purpose of this study is to compare the clinical performance of three silicone hydrogel contact lenses over a 2 week period.


Eligibility criteria:
inclusion criteria: * be no less than 18 and no more than 39 years of age. * sign written informed consent and investigator to record this on case report form. * be willing and able to adhere to the instructions set out in the protocol. * be an existing successful daily wear soft contact lens wearer. for the purposes of this study this means wearing lenses for at least 6 hours per day, 5 days per week for the last month. * no extended wear in the last 3 months. * subjective refraction must result in a vertex corrected spherical contact lens prescription between -1.00 and -6.00 diopters. * have refractive astigmatism less than or equal to 1.00 diopters (d) in both eyes. * achieve visual acuity of 6/9 (20/30) or better in each eye. * require a visual correction in both eyes (no monovision allowed). * have normal eyes with no evidence of abnormality or disease. for the purposes of this study a normal eye is defined as one having: no amblyopia, no evidence of lid abnormality or infection (including blepharitis/meibomitis), no conjunctival abnormality or infection, no clinically significant slit lamp findings (i.e. stromal edema, vascularization, infiltrates or abnormal opacities), no other active ocular disease. exclusion criteria: * requires concurrent ocular medication. * clinically significant corneal stromal haze, corneal vascularization, tarsal abnormalities, bulbar hyperemia, limbal hyperemia, or any other abnormality of the cornea that would contraindicate contact lens wear. * clinically significant corneal staining * requires presbyopic correction (i.e. not using any presbyopic correction and measured add power of less than +1.00 diopters). * has had refractive surgery. * has had eye injury/surgery within 8 weeks immediately prior to enrollment for this study. * abnormal lacrimal secretions. * pre-existing ocular irritation that would preclude contact lens fitting. * keratoconus or other corneal irregularity. * hard, hybrid or rigid gas permeable lens wear in the previous 8 weeks. * any systemic illness which would contraindicate lens wear or the medical treatment of which would affect vision or successful lens wear. * diabetic. * infectious disease (e.g., hepatitis, tuberculosis) or an immunosuppressive disease \[e.g., human immunodeficiency virus (hiv)\]. * history of chronic eye disease (e.g. glaucoma or age related macular degeneration). * pregnancy, lactating or planning a pregnancy at the time of enrollment. * participation in any concurrent clinical trial or in last 30 days
costal cartilage donor-site pain: does abdominal muscle infiltration analgesia work?

Conditions: Rectus Abdominis and External Oblique Muscle Infiltration Analgesia

Summary: donor-site pain is an adverse effect of autologous ear reconstruction. a well-planned pain management protocol is needed. the objective of this study was to introduce rectus abdominis and external oblique muscle infiltration analgesia (ram+eom-ia) in autologous ear reconstruction and to evaluate its efficacy and safety.

patients were included in two cohorts: intermittent ram+eom-ia combined with intravenous patient-controlled anesthesia (ipca) and ipca alone. the primary outcome was the numerical rating score (nrs) of pain recorded during 48 h postoperatively. secondary outcomes included the barthel index and rescue analgesic consumption. additionally, areas of sensory block were tested using a cold stimulus.

Eligibility criteria:
inclusion criteria: * all patients were microtia and underwent the first stage of autologous ear reconstruction by the same experienced surgeon in first affiliated hospital of fujian medical university. exclusion criteria: * patients were excluded if they over 18 years old; discontinued analgesic therapy; regularly used opioids, other analgesics, sedative medications, or corticosteroids; were unable to express pain scores due to comorbidities such as mental retardation; or had incomplete data.
enhancing community capacity to improve cancer care delivery

Conditions: End of Life; Cancer

Summary: undertreated patient symptoms and resulting acute care use require approaches that improve symptom-burden. previously a a lay health worker (lhw)-led symptom screening intervention was developed for patients with advanced cancer. this intervention will be expanded to all patients with cancer and the lhw will be trained to refer patients to palliative care and behavioral health. this intervention will evaluate the effect on symptom-burden, survival, healthcare use, and total costs.

from 11/1/2016 - 9/30/2018, all newly diagnosed medicare advantage enrollees with solid or hematologic malignancies were enrolled in the intervention. outcomes were compared outcomes to patients in the year prior (control arm). the primary outcome was change in symptoms using the edmonton symptom assessment scale (esas) and personal health questionnaire-9 (phq-9) at baseline, 6- and 12-months post-enrollment. secondary outcomes were between-group comparison of survival, 12-month healthcare use and costs.

Eligibility criteria:
inclusion criteria: * newly diagnosed with cancer * diagnosis of relapse or progressive disease (any cancer diagnosis) as identified by imaging or biopsy and confirmed by physician. * must be 18 years or older. * must have capacity to verbally consent exclusion criteria: -inability to consent to the study due to lack of capacity as documented by the referring physician.

Keywords: cancer end of life patient-centered
assessment of the cyberlink control system for use by the amyotrophic lateral sclerosis (als) patient

Conditions: Amyotrophic Lateral Sclerosis; Neurodegenerative Disease; Motor Neuron Disease

Summary: the goal of this project is to determine whether this device is a practical and realistic means for als patients to operate their computers with only the use of facial, brainwave, and eye movements. this study is intended to evaluate both the complexity of the system and the degree to which complications of als (such as severity of involuntary movements) may interfere with the use of cyberlink.


Eligibility criteria:
inclusion criteria: * those aged 18-75 diagnosed with probable or definite als. exclusion criteria: * those with decision impairment will not be considered.

Keywords: amyotrophic lateral sclerosis cerebrospinal fluid neurodegenerative disease motor neuron disease autonomic nervous system neurodegenerative diseases movement disorders
can patients with atrial fibrillation safely discontinue anticoagulant therapy after cardiac surgery? (atlaac)

Conditions: Atrial Fibrillation; Left Atrial Appendage Absent; Anticoagulant Adverse Reaction

Summary: left atrial appendage (laa) closure has become a frequent addition to oral anticoagulation in patients with atrial fibrillation who undergo cardiac surgery. the procedure significantly reduces the risk of stroke and systemic embolism, which may render anticoagulation unnecessary or even harmful when considering the associated increased risk of bleeding. a clinical trial to address the need for anticoagulation after laa closure is needed. the atlaac trial will enroll 1220 patients with atrial fibrillation who have previously undergone surgical laa closure. patients will undergo a cardiac ct-scan to determine if laa closure was successful and patients with successful closure will be randomized to continue or discontinue anticoagulation. the trial will assess the risk of ischemic stroke, peripheral arterial embolism, and major bleeding during the randomized intervention


Eligibility criteria:
inclusion criteria: * age \> 18 years * previously undergone any type of cardiac surgical procedure including any type of surgical laa closure (use of any of the following techniques; amputation and suture closure, stapler closure, non-amputating suture closure or closure with an approved surgical occlusion device (e.g. atriclip)) according to the nationalpatient register (npr), the danish heart registry (dhr) or the western danish heart registry (wdhr) from january 1st 2010 til 3 months prior to inclusion in the project. * documented history of paroxysmal, persistent, or permanent atrial fibrillation or atrial flutter according to the electronic patient record * informed consent exclusion criteria: * not receiving oac (warfarin/doac) * patient specific conditions requiring oac (e.g.mechanical valve, previous pulmonary embolism) * renal impairment (estimated glomerular filtration rate \< 30) * allergy to contrast media * pregnancy or breastfeeding

Keywords: atrial fibrillation anticoagulant treatment surgical left atrial appendage closure surgical left atrial appendage occlusion
maternal and fetal outcomes in pregnant women with covid -19,a cross sectional study

Conditions: COVID-19 Pandemic

Summary: the spread of a new coronavirus (sars-cov-2) from wuhan, china, has been fast, and the world health organization (who) declared a pandemic on march 11th, 2020 .it has now spread worldwide and is one of the most severe public health threats.the clinical characteristics of covid-19 and the likelihood of transmission vertically or during delivery in pregnant women are still unknown.

in this cross sectional study,the following questions require immediate attention: whether covid-19 symptoms in pregnant women differ from symptoms in non-pregnant women; whether disease complications and mortality rates are higher in pregnant women than in non-pregnant women; and whether there is a risk of premature delivery, foetal mortality, or even vertical transmission of the disease. these questions must be answered in order to plan optimal obstetrical management for pregnant women with covid-19

Eligibility criteria:
inclusion criteria: * pregnant women of any gestational age with confirmed covid 19 diagnosis attended and admitted at inpatient ward for management and follow up from april 2020 to december 2021at kasr el ainy hospital,cairo university exclusion criteria: * there is no exclusion criteria
a dose ranging vehicle controlled study to determine the safety and efficacy of permethrin foam, 5% and permethrin foam, 4% for the treatment of scabies

Conditions: Scabies

Summary: to determine and compare the safety and efficacy of permethrin foam 4% and permethrin foam 5% with that of vehicle in subjects with scabies.

it is anticipated that a majority of subjects will require and receive a single treatment; however, those subjects not showing improvement at the follow-up visit 2 weeks after initial treatment will be treated a second time. those subjects originally assigned to vehicle for the first treatment will receive a "re-treatment" with one of the active doses.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of active scabies infection. * subject is in good general health with normal appearing skin in noninfested areas. * females must be post-menopausal, surgically sterile or use an effective method of birth control with a negative pregnancy test (10 years of age and older) at study start. exclusion criteria: * subject is pregnant, lactating, or is planning to become pregnant during the study. * subject has used any ectoparasiticide within the three weeks prior to study start. * subject has signs of systemic infection or is receiving systemic therapy for an infectious disease. * subject has severe cutaneous bacterial or fungal infections requiring therapy or heavily crusted lesions consistent with norwegian scabies. * subject is currently enrolled in an investigational drug or device study or has used an investigational drug or device within 30 days prior to study start. * subject whose close personal contacts will not comply with standard of care for fomite management.

Keywords: sarcoptes scabiei scabies ectoparasite parasite infestation renaissance
a study to assess the safety, tolerability and pharmacokinetics of metronidazole injection in healthy japanese subjects

Conditions: Infection

Summary: the purpose of this study is to assess the safety, tolerability and pharmacokinetics of metronidazole following single and multiple intravenous infusion in healthy japanese adult subjects.


Eligibility criteria:
inclusion criteria: * healthy japanese male and/or female subjects. exclusion criteria: * subject with evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or allergic disease (including drug allergies, but excluding untreated, asymptomatic, seasonal allergies at the time of dosing). * subject with history of regular alcohol consumption exceeding 7 drink/week for females or 14 drinks/week for males \[1 drink = 5 ounces (150 ml) of wine or 12 ounces (360 ml) of beer or 1.5 ounces (45 ml) of hard liquor\] within 6 months of screening.

Keywords: metronidazole infusion
diabetes and gastric by- pass

Conditions: Type 2 Diabetes

Summary: the purpose of this study is to evaluate the mechanisms leading to rapid postoperative improvement in diabetes following gastric by-pass surgery for obesity.we will evaluate and compare the changes in glucose level, beta-cell function, and insulin resistance induced by a week of very low calorie liquid diet and those induced by a week of matched very -low calorie liquid diet occuring in the context of routine postoperative care following rygb.

volunteers planned to undergo rygb will be studied during two-9 days periods of identical and controlled diet and activity, separated by a 4-10-week washout period. study period #1: this first study period is 9 days/nights long and requires you to be closely supervised at our clinical and translational research center (ctrc). during this time you will receive the same diet and are expected to have the same activity level you will be prescribed in the immediate post-operative period. wash-out period: during this study period you are expected to return to your usual diet and exercise level. study period #2: this last study period is also 9 days/nights long, includes the exact same diet you have received during the first study period, and in addition you will undergo the planned gastric by-pass surgery. procedures during the research: mixed meal challenge test will be done four times during the entire study: days 1 and 9 for each study period. this test allows the investigators to evaluate how much insulin your body is producing and how well this insulin is processed. measurement of resting energy expenditure will be done four times during the entire study. this test tell us how much energy your body is burning up in a resting state.

Eligibility criteria:
inclusion criteria: * volunteers that are planned to undergo rygb(roux-en-y by pass) and have type 2 diabetes diagnosed within the prior 10 years. exclusion criteria: * abnormal renal function * significant anemia * difficult venous access * treatment with incretin mimetics or dpp iv inhibitors in the prior 3 months * recent change in use of any pharmacologic agent with potential effect on either beta-cell function or insulin resistance. * pregnancy * non -english speakers

Keywords: type 2 diabetes bariatric surgery obesity weight loss
the impact of musical engagement on medical resident well-being

Conditions: Burnout; Student Burnout; Physical Disability; Resident Doctor; Music Therapy; Music; Stress; Wellness, Psychological

Summary: it is common knowledge that music has a positive impact on human well-being. it is also well-known that medical residents are frequently stressed and burnt out. with these two thoughts in mind, the investigators want to explore how participating in a musical engagement program may positively impact medical resident well-being. the investigators hope to do this by hosting four informal musical engagement sessions with medical residents, which will involve playing instruments, improvising, and reading sheet music. to study the impact that this program has on participants, investigators will ask participants to complete a survey. the investigators hope to find that participants are positively impacted by participation in the study, in terms of factors like stress reduction and minimized burnout symptoms. hopefully, the study results may inform residency program curriculum designers in the future may incorporate music into wellness programming.


Eligibility criteria:
inclusion criteria: 1. participants will be residents in the family medicine program at mcmaster university, in any year of study 2. participants may be on any rotation in their program schedule and located at any site 3. participants may be of any gender identity, age, ethnicity, and sexual orientation 4. must identify as a "musician", whether casual, professional, or somewhere in between - however, they require enough musical training so that they may comfortably participate in the planned sight reading and improvisation within the study 5. participants must be able to supply their own physical instrument for sessions 6. must be aged 18 or over 7. must be english-speaking exclusion criteria: 1. potential participant may not be a resident of any other residency program, or be from a university other than mcmaster 2. if a participant is unable to participate in two or more musical sessions, they will not be included in this study 3. if a participant is unable to complete the qualitative and quantitative survey forms in their entirety, they will not be included in this study
a pilot study to evaluate the efficacy of ariva® silver wintergreen, a smoking aversive lozenge

Conditions: Tobacco Use Disorder; Smoking

Summary: this is a study to determine the safety and effectiveness of silver salt in ariva® silver wintergreen lozenge on discouraging smoking, by its imparting an unfavorable taste to the smoker when tobacco is smoked.

each subject will be given an ariva® silver wintergreen lozenge or a placebo wintergreen lozenge on a random basis. once the lozenge has dissolved in the mouth, subjects will smoke one of their own cigarettes, and will answer questions about the experience and their craving for a cigarette. after a washout period, each subject will repeat the steps with the second type of lozenge.

Eligibility criteria:
inclusion criteria: * healthy adult smoker * smoking for at least 5 years * smoking at least one (1) pack of cigarettes a day * interest in quitting smoking exclusion criteria: * known allergy to silver or silver salts * pregnant or breast-feeding * current drug or alcohol abuse, and/or history of drug or alcohol dependence within 3 months of study

Keywords: smoking smokeless aversion nicotine nicotine replacement