effect of intradialytic continuous versus interval aerobic exercises on functional capacity in patients with chronic renal failure.

Conditions: Chronic Kidney Diseases

Summary: chronic kidney disease has emerged as one of the leading causes of mortality worldwide, and it is one of a small number of non-communicable diseases that have shown an increase in associated deaths over the past 2 decades. the high number of affected individuals and the significant adverse impact of chronic kidney disease should prompt enhanced efforts for better prevention and treatment. chronic kidney disease is a serious medical problem, as it is associated with high risks of complications which lead to poor quality of life and physical capacity.

sixty-seven patients undergoing haemodialysis randomly be allocated into three groups, (a, b \& c). group a (low- to moderate-continuous intensity cycling exercises, group b (moderate- to high-interval intensity cycling exercises), the exercises performed two sessions per week for two months and group (c)twenty three patients received the hemodialysis sessions only. group a (low- to moderate-continuous intensity cycling exercises: twenty three patients performed aerobic exercise during dialysis using pedal machine at low- to moderate continuous intensity rating from 11 to 13 on the borg scale for 15-30 minutes. warming up and cool down (approximately 10 minutes) in form of free active exercise of the lower extremities. group b (moderate- to high-interval intensity cycling exercises), twenty one patients performed aerobic exercise during dialysis using pedal machine at moderate-to-high interval intensity rating from 12 to 15 on the borg scale for 15-30 minutes. warming up and cool down (approximately 10 minutes) in form of free active exercise of the lower extremities. inclusion criteria: 1. sixty seven patients of both sexes 2. age will range from 35-55 years old. 3. bmi will be from 25-34.5 kg/m2. 4. all patients with stage 5 of crf. 5. all patients are stable on dialysis for at least six months before the study. 6. stable medical and clinical hemodynamic state. exclusion criteria: 1. patients with hearing impairment or mental disorder. 2. patients with unstable angina, uncontrolled cardiac arrhythmia, decompensated heart failure, persistent systolic blood pressure (bp) greater than 200 mmhg, persistent diastolic bp greater than 120 mmhg, acute pericarditis or myocarditis. 3. patients with auto-immune diseases. 4. chronic inflammatory orthopedic disorders and rheumatoid arthritis. 5. patients with history of neuromuscular disease (muscular dystrophy, myasthenia gravis, myopathy, multiple sclerosis and peripheral neuropathy). 6. patients with chronic obstructive lung disease, restrictive lung disease or chronic chest infection. 7. patients with bmi \> 35kg/m2.

Eligibility criteria:
inclusion criteria: 1. sixty-seven patients of both sexes 2. age will range from 35-55 years old. 3. bmi will be from 25-34.5 kg/m2. 4. all patients with stage 5 of crf. 5. all patients are stable on dialysis for at least six months before the study. 6. stable medical and clinical hemodynamic state. exclusion criteria: * 1. patients with hearing impairment or mental disorder. 2. patients with unstable angina, uncontrolled cardiac arrhythmia, decompensated heart failure, persistent systolic blood pressure (bp) greater than 200 mmhg, persistent diastolic bp greater than 120 mmhg, acute pericarditis or myocarditis. 3. patients with auto-immune diseases. 4. chronic inflammatory orthopedic disorders and rheumatoid arthritis. 5. patients with history of neuromuscular disease (muscular dystrophy, myasthenia gravis, myopathy, multiple sclerosis and peripheral neuropathy). 6. patients with chronic obstructive lung disease, restrictive lung disease or chronic chest infection. 7. patients with bmi \> 35kg/m2.

Keywords: intradialytic cycling exercise, function capacity, hemodialysis, quality of life.