Kornimate/medical-research-clean huggingface dataset:
epiduroscopic laser discectomy procedures

Conditions: Disc, Herniated

Summary: epiduroscopy or spinal endoscopy is the imaging of the epidural space using a percutaneous and minimally invasive fiberoptic imaging device. the definitive diagnosis and treatment of chronic pain is increasingly prevalent with epiduroscopy. recently, as a result of these studies it has been reported that laser therapy with epiduroscopy applied discectomy during multiple lesions. investigators aimed to retrospectively investigate the efficacy of epiduroscopic discectomy procedures performed at the algology clinic.

in this study, epiduroscopic discectomy procedures performed between january 2012 and july 2016 at the algology clinic of the department of anesthesiology and reanimation, sakarya university training and research hospital, were examined retrospectively. after approval was received from the sakarya university faculty of medicine's ethics committee, patient information was obtained from the karmed (kardelen software, turkey) hospital information system. files were scanned from the hospital archive. the age, gender, weight, lumbar disc herniation level, preoperative and postoperative surgical history, amount of physiological saline used during the procedure and duration of the procedure, whether a lumbar epidural steroid (les) was used during the procedure, the amount of epiduroscopic laser use during the procedure, and complications after the procedure were examined. the oswestry disability index (odi) and visual analogue scale (vas) scores were recorded preoperatively, as well as after 2 weeks and 2, 6, and 12 months postoperatively from the patient files. the 2007 number cruncher statistical system (ncss, kaysville, utah, usa) program was used for statistical analysis. the student t-test and mann-whitney u test were used for descriptive statistical methods (mean, standard deviation, median, frequency, ratio, minimum, maximum) in two groups, as well as the normal distribution of quantitative data. the kruskal-wallis test and mann-whitney u test were used in the comparison of three groups with no normal distribution. the pearson chi-square test was used to evaluate qualitative data, and spearman's correlation analysis was used to evaluate intervariable relationships. the friedman and wilcoxon signed ranks tests were used in the evaluation of three or more follow-up parameters without normal distribution. diagnostic screening tests (sensitivity, specificity) and receiver operating characteristic (roc) analysis were used to determine the cutoff value for age. significance was evaluated at the level of p \< (0.01).

Eligibility criteria:
inclusion criteria: 1. patients with low back and / or leg pain for at least 3 months or more 2. patients who do not benefit from conservative treatment 3. in patients who underwent lumbar mri examinations and had axial sheaths with a herniation of 3 mm or more exclusion criteria: 1. patients with bleeding diathesis in preoperative laboratory tests 2. patients with any local or systemic infection

Keywords: epiduroscopy discectomy holmium yag laser lumbar disc herniation minimally invasive treatment
genetic etiology in premature ovarian insufficiency

Conditions: Primary Ovarian Insufficiency; Genetic Predisposition to Disease

Summary: premature ovarian insufficiency (poi), first described by albright in 1942, is defined as an increase in follicle stimulating hormone (fsh), an insufficiency of the ovarian function leading to an early menopause (\<40 years of age).today, only 35% of poi's etiology can be explained. causes enlightening poi may be enumerated as follows, according to their frequency: genetic mutations, autoimmune defects and abnormalities detected on the x chromosome.the purpose of the study is to determine the frequency of the genetic abnormalities and polymorphisms described above in the poi turkish population


Eligibility criteria:
inclusion criteria: * clinical diagnosed premature ovarian failure patients * 20-40 years old female patients exclusion criteria: * surgical surgical menopause * female patients who can't meet the age range criteria

Keywords: premature ovarian insufficiency (poi)
acute pain memory among former burned: exploration of fmri.

Conditions: Magnetic Resonance Imaging; Neuronal Activity

Summary: pain is complex phenomenon misunderstood in spite of medical progress and neurosciences. that's why the relief of chronic pain is only partial for a lot of infection as arthrosis, chronic back pain, headaches or neuropathic pain. certain situations bring to relive pain sensation. investigators were interested to former burned. they wonder about somatic memory and unconscious of acute.

it is a comparative and monocentric study. there are two groups. on the one hand, there is the former burned and, on the other hand, healthy volunteers. while they thought to painful memory or not, functional magnetic resonance imaging (fmri) will be performed. then, investigators compare two functional magnetic resonance imaging (fmri). main objective of this study is link up between brain activity by functional magnetic resonance imaging (fmri) and acute pain memory.

Eligibility criteria:
inclusion criteria: for control group: * affiliated or entitled to a social security * have signed consent before their participation in the study * adult women and men french and is right handed * vision and hearing normal or corrected for former burned: * affiliated or entitled to a social security * have signed consent before their participation in the study * adult women and men french and is right handed * vision and hearing normal or corrected * localized burn at the hand or feet onset between 12 and 24 years * not sequelae painful at the inclusion * scope and depth of the burn according to classifications cim 10 exclusion criteria: for control group: * any contraindications to pass an fmri test * neuropathic pains and psychiatric disorders * medical history of head injuries * burn presence for former burned: * any contraindications to pass an fmri test * neuropathic pains and psychiatric disorders * medical history of head injuries

Keywords: pain brain responses neuroimaging fmri burn memory
the turkish version of the smartphone impact scale

Conditions: Addiction Psychological; Healthy; Addiction

Summary: smartphone impact scale (sis) was originally developed in english to determine the cognitive, affective, social, and behavioral impacts of smartphones in everyday life. the purpose of this study was to translate and cross-culturally adapt the sis instrument into turkish and investigate its psychometric properties.

smartphone impact scale (sis) was originally developed in english to determine the cognitive, affective, social, and behavioral impacts of smartphones in everyday life. the purpose of this study was to translate and cross-culturally adapt the sis instrument into turkish and investigate its psychometric properties. two hundred healthy young adults will include. for cross-cultural adaptation, two bi-lingual translators used the back-translation procedure. within a 5-to-7-day period after the first assessment, the participants completed the turkish version of sis (sis-t) to evaluate test-retest reliability. cronbach's alpha (α) was used to assess internal consistency. the correlations with the turkish version of the smartphone addiction scale (sas-t) and turkish version of the nottingham health profile (nhp-t) will determine to check the validity.

Eligibility criteria:
inclusion criteria: * aged between 18 and 35 years * having a smartphone that was connected to the internet for at least 6 months * being a volunteer to participate exclusion criteria: * having cognitive impairment * having disabilities in understanding, speaking and reading turkish

Keywords: smartphone technological addiction smartphone psychosocial impact smartphone use
dual antiplatelet therapy tailored on the extent of platelet inhibition

Conditions: Unstable Angina; NSTEMI

Summary: the purpose of this study is to evaluate the efficacy (reduction of major ischemic events at 6 and 12 months of follow-up) of a tailored clopidogrel therapy in patients with ua/nstemi undergoing pci with stent implantation and wiht a documented residual platelet reactivity assessed by a point of care system (verifynow p2y12).

several studies documented the presence of a high variability in the individual response to antiplatelet therapies in terms of extent of platelet function inhibition. this laboratory finding is the so-called aspirin or clopidogrel resistance which we prefer to define residual platelet reactivity (rpr) on antiplatelet therapy. a growing body of evidence is demonstrating the clinical relevance of this laboratory parameter, i.e. patients with rpr are at higher risk of a subsequent adverse cardiovascular event. in particular, it has been demonstrated that rpr measured by light transmittance aggregometry induced by adp or by the point of care assay verifynow p2y12 identifies patients which, after coronary revascularization with stent implantation, at higher risk of a potentially catastrophic event such as stent thrombosis. no randomized trials are available in the literature on the efficacy and safety of an antiplatelet therapy tailored on the extent of platelet function inhibition.

Eligibility criteria:
inclusion criteria: * unstable or nstemi exclusion criteria: previous bleeding events which have required blood transfusion * pt- inr \>1.5 * platelet count ≤ 100000/ mm3 * hb \< 10 g/dl * previous tia/stroke (ischemic or hemorrhagic or unknown) * body weight \< 60 kg * creatinine levels ≥ 4 mg/dl * cerebral neoplasia * recent major trauma/surgery/head injury (within 3 previous weeks) * gastrointestinal hemorrhage in the last month * aortic dissection * known haemorrhagic diathesis * oral anticoagulant therapy * pregnancy or 1 week after delivery * uncontrolled hypertension (systolic \>180 mmhg or diastolic \>110 mmhg) * severe liver disease * infective endocarditis * major psychiatric disorders * alcool or drug abuse * active peptic ulcer noncompressible arterial puncture within 14 days prolonged cardiopulmonary resuscitation

Keywords: clopidogrel therapy platelet function inhibition
combination chemotherapy in treating older women with metastatic breast cancer

Conditions: Breast Cancer

Summary: rationale: drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. combining more than one chemotherapy drug may kill more tumor cells. purpose: phase ii trial to study the effectiveness of combination chemotherapy in treating older women who have metastatic breast cancer.

objectives: * determine the survival without degradation of quality of life in elderly women with metastatic breast cancer treated with leucovorin calcium, fluorouracil, and mitoxantrone. * determine the efficacy of this regimen, in terms of response and survival without progression, in these patients. * determine the tolerance of these patients to this regimen. outline: this is a multicenter study. patients receive mitoxantrone iv and leucovorin calcium iv over 2 hours on day 1. patients then receive fluorouracil iv over 46 hours on days 1-2. treatment repeats every 21 days for a maximum of 8 courses in the absence of disease progression or unacceptable toxicity. quality of life is assessed at baseline, after 3 courses, and at treatment completion. patients are followed every 3 months. projected accrual: a total of 39 patients will be accrued for this study.

Eligibility criteria:
disease characteristics: * histologically confirmed metastatic adenocarcinoma of the breast * bidimensionally measurable or evaluable disease * at least one non-irradiated lesion that is at least 2 cm in the greater diameter or * serous drainage, cutaneous metastasis, osseous metastasis, etc. * no symptomatic cerebral metastasis * hormone receptor status: * not specified patient characteristics: age: * 75 to 90 sex: * female menopausal status: * postmenopausal performance status: * who 0-2 life expectancy: * at least 3 months hematopoietic: * platelet count at least 100,000/mm\^3 * absolute neutrophil count at least 1,500/mm\^3 hepatic: * alkaline phosphatase less than 3 times normal * bilirubin less than 1.5 times normal * transaminases less than 3 times normal * total protein greater than 60% * albumin greater than 30 g/l renal: * creatinine clearance greater than 60 ml/min cardiovascular: * lvef greater than 50% by echocardiogram or scintigraph * ecg normal * no uncontrolled angina * no myocardial infarction within past 6 months other: * no other medical illness or condition that would preclude study * no other prior malignancy except basal cell skin cancer or curatively treated carcinoma in situ of the cervix * no psychological, social, familial, or geographical reasons that would preclude study prior concurrent therapy: biologic therapy: * not specified chemotherapy: * prior adjuvant chemotherapy allowed * no prior adjuvant anthracyclines * no prior chemotherapy for metastatic disease endocrine therapy: * one or two prior regimens of hormonal therapy allowed for metastatic disease radiotherapy: * no prior radiotherapy for metastatic disease surgery: * not specified other: * no concurrent participation in another study

Keywords: stage iv breast cancer recurrent breast cancer
promise i early feasibility trial of the limflow stent graft system

Conditions: Critical Limb Ischemia; Chronic Limb-Threatening Ischemia

Summary: this pilot study will investigate the safety, effectiveness and feasibility of the limflow stent graft system for creating an av fistula in the below the knee (btk) vascular system using an endovascular, minimally invasive approach for the treatment of critical limb ischemia (cli) in subjects ineligible for conventional endovascular or surgical limb salvage procedures.

the promise i trial was a prospective, multi-center, single-arm, investigational feasibility study assessing the limflow system for the treatment of chronic- limb-threatening ischemia by creating an arterio-venous fistula in the below-the-knee vasculature. the study was run under an investigational device exemption (ide g160156, nct03124875). thirty-two subjects were enrolled under protocol revisions a, b, c, and d at seven sites in the united states between 5-july-2017 and 8-april-2019.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of critical limb ischemia with hemodynamic evidence of severely diminished arterial inflow of the index limb and rutherford classification 5 r 6 * reviewed and approved for eligibility by the investigator and the independent safety committee (isc) exclusion criteria: * concomitant hepatic or renal insufficiency, thrombophlebitis, deep venous thrombus, coagulation disorder * severe heart failure, recent mi or stroke * significant peripheral edema or infection that may preclude insertion of a prosthesis or significantly impair wound healing * known allergies or contraindications to anti platelet therapy or device materials * immunodeficiency disorder or immunosuppressant therapy * life expectancy \< 12 months

Keywords: transcatheter arterialization of deep veins percutaneous deep vein arterialization limflow system
adaptive cardiac resynchronization therapy optimization at rest and during exercise (adopt crt)

Conditions: Heart Failure

Summary: the adopt cardiac resynchronization therapy (crt) study is an acute, prospective, multi-center, non-randomized investigational study designed to compare indices of cardiac function at device settings optimized using the investigational adaptive crt (acrt) algorithm versus nominal programming. the comparison will be performed during rest, atrial pacing and sub-maximal exercise. adopt crt is a sub study of the adaptive crt study (ntc00980057) being conducted in europe.

adaptive crt is an implantable heart failure device feature that attempts to optimize crt without echocardiographic testing.

Eligibility criteria:
inclusion criteria: * subject is age 18 or greater * subject is willing to sign and date the study informed consent form * subject has been implanted with a clinically indicated crt-d device (medtronic vision 3d or protecta models) for at least 1 month but less than 7 months from the date of study enrollment exclusion criteria: * subject has a history of persistent or permanent af for which pharmacological therapy and/or cardioversion have been unsuccessful or have not been attempted. * subject has atrial or ventricular tachyarrhythmias or frequent atrial or ventricular ectopy at the time of enrollment. * subject's resting heart rate at the time of enrollment exceeds 90 bpm. * subject had crt system implanted for more than 7 months from the date of the study enrollment * subject has complete av block. * subject had previous mechanical valve surgeries. * subject has congenital heart disease. * subject has contraindication for an exercise test. * subject is unable to perform a sub-maximal exercise test. * it is not possible to acquire technically acceptable echocardiographic images. * subject has medical conditions that would limit study participation. * subject is pregnant (all women of child-bearing potential must undergo a pregnancy test within seven days prior to the study visit). * subject is enrolled in the adaptive crt study * subject is enrolled in concurrent studies which could confound the results of this study. * subject meets exclusion criteria required by local law
national survey on hypertension in cardiologic private practice

Conditions: Hypertension

Summary: to evaluate (with sufficient accuracy) the profile(demographic and clinical characteristics, health care management) of hypertensive patients seen in private cardiology consultation by holding account of type of exercise of the cardiologist (private exclusive or mixed hospital and private).


Eligibility criteria:
inclusion criteria: * male or female \> or = 18 years old * known hypertension * agree to take part in this study exclusion criteria: * none

Keywords: hypertension private cardiology consultation patients with hypertension
pharmacological, clinical and statistical assessment of a new tool available for pharmacodependence report evaluation

Conditions: Drug Abuse; Drug Dependence

Summary: in france, the afssaps is the body in charge of the evaluation of pharmacodependance. in order to fulfil its mission, the afssaps has created a network of 11 centres for evaluation and information on pharmacodependance (ceip), coordinated by the drugs and psychotropics unit. pharmacodependence notifications issued by professionals are collected by each centre which evaluates them. nantes' ceip created an original tool to harmonize case reporting and make it possible to homogeneously evaluate the seriousness of pharmacodependence cases as each ceip had his own way of analysing his cases. the aim of this study is to assess this tool.


Eligibility criteria:
inclusion criteria: * case report from one of the french ceip for drug and substance problematic use, abuse or dependence except alcohol and tobacco.

Keywords: drug and substance problematic use, abuse or dependence
conventional collagen crosslinking in young keratoconus

Conditions: Keratoconus

Summary: keratoconus is a chronic progressive non - inflammatory disorder characterised by progressive steepening and thinning of cornea and high myopic astigmatism, accounting for poor visual acuity in such individuals. keratoconus seems to be more advanced on presentation, in young patients. the investigators intend to evaluate the effectiveness of conventional collagen cross linking in young patients diagnosed with keratoconus.

keratoconus is progressive ectatic corneal disorder characterised by progressive corneal thinning, steep corneal curvatures and usually associated with high irregular myopic astigmatism. the major problems concerning keratoconus in young patients are; 1. rapid rates of progression in young keratoconic corneas as compared to adults. 2. poor biomechanical properties of young corneas. 3. poor quality of vision, which predisposes to a very poor quality of life. 4. high rates of complications and failure post keratoplasty in young patients. the investigators intend to evaluate the effectiveness of conventional collagen crosslinking in young patients with keratoconus with regards to keratometric indices and visual acuity.

Eligibility criteria:
inclusion criteria: * patients aged 18 years and below. * patients diagnosed to have keratoconus at presentation and willing for follow - up at regular intervals post treatment. exclusion criteria: * any disease causing abnormal topography other than keratoconus. * any ocular condition predisposing towards poor vision (retinal , lens problems)

Keywords: paediatric, keratoconus, collagen cross linking
ppar-combo with sulfonylurea

Conditions: Metabolics Diabetes Nos

Summary: a phase 3, randomized, double-blind, placebo controlled, multicenter trial to evaluate the safety and efficacy of bms-298585 in combination with glyburide therapy in subjects with type 2 diabetes mellitus who have inadequate glycemic control on sulfonylurea therapy alone.


Eligibility criteria:
inclusion criteria: * type 2 diabetes, hba1c \> 7.0% and \< 10.0%, mean serum triglyceride \< 600 mg/dl, body mass index \< 41 kg/m2, fasting c-peptide . 1.5 ng/ml. exclusion criteria: * history of mi (myocardial infarction), coronary angioplasty or bypass graft(s), valvular disease or repair, unstable angina pectoris, transient ischemic attack (tia), cerebrovascular attack, or cerebrovascular accident (cva) within 6 months, congestive heart failure (nyha class iii and iv, uncontrolled hypertension, history or renal disease, peripheral vascular disease (pvd), pulmonary disease, gastrointestinal disease, active liver disease or endocrine disease.
different arm positions during single leg squat

Conditions: Knee Injuries and Disorders

Summary: the aim of this study is to compare the effects of different arm positions on muscle activity during single leg squat.

the aim of our study is to examine the effect of different positions of the arms on lower extremity muscle activations during single leg squat (sls). this prospective cross sectional study included single leg squat test assessments in different arm positions: 1) arms free, 2) arms flexed 90 degrees, 3) hands on hip, 4) arms across the chest. inclusion criteria were being a young adult (20-30 years old), physical activity level of at least 4 on the tegner activity scale, and volunteering to participate in the study. those with a history of lower extremity injury in the last 1 year will be excluded from the study. our study will contribute to distinguishing sls variations for clinicians and researchers and choosing the appropriate sls for evaluation and treatment.

Eligibility criteria:
inclusion criteria: * being between the ages of 20-30 * physical activity level of at least 4 on the tegner activity scale, exclusion criteria: * history of lower extremity injury in the last 1 year * central or peripheral vestibular disorders

Keywords: healthy subject movement analysis muscle activity kneeling