Kornimate/medical-research-clean huggingface dataset:
role of skin cleansing and prophylactic antibiotic in preventing infectious morbidity after cesarean section delivery

Conditions: Postpartum Infectious Morbidity in Cesarean Section Delivery

Summary: this study aims to determine the effectiveness of skin cleansing and prophylactic antibiotics given to women undergoing a cesarean section for reducing the incidence of postpartum infectious morbidity and to assess potential maternal adverse effects and any impact on the infant.


Eligibility criteria:
inclusion criteria: 1. women undergoing cesarean delivery, both elective and non-elective. 2. rupture of membranes and labor contractions will be allowed. exclusion criteria: 1. unknown outcome from the patient. 2. refusing to participate in the study from the admission conse 3. allergy to antibiotics. 4. any visible infection.
sp tlf versus ho:yag laser

Conditions: Urinary Calculi

Summary: the investigators aim to compare the performance of the super pulse thulium fiber laser (sp tfl) with that of the standard holmium: yttrium-aluminium-garnet (ho:yag) laser. the investigators hypothesize that the electronically-modulated laser diodes, of the tfl offers the most comprehensive and flexible range of laser parameters among laser lithotripters leading to more efficient (4 times more) and effective stone dusting resulting in production of finer dust particles obviating the need for postoperative ureteric stenting which remains a major source of patient discomfort.


Eligibility criteria:
inclusion criteria: * patient is scheduled to undergo mini-pcnl and/or rirs surgery at the university of rochester medical center for the management of upper urinary tract calculi (i.e. kidney and proximal ureter) * stones located in the kidney and proximal ureter * stones measuring 10-30mm * ability to give informed consent * any racial or ethnic origin * age 18 years and older exclusion criteria: * active kidney infection * patients with prior stenting * pregnant patients * patients with solitary kidney * patients with ureteral tumor or stricture * inability to give informed consent * not age 18 and older
patient time and in-hospital delay of surgery association with complicated appendicitis

Conditions: Acute Appendicitis

Summary: this is a retrospective observational study with its main aim of evaluating possible factors associated with complicated appendicitis. current literature supports time from symptom onset until registration as the main and maybe only determinant of the outcome if patients are operated on within 24 hours. we wish to evaluate whether this is true in all patients, or there are subgroups in which time from registration to operation is associated with complicated appendicitis.

the data to be analyzed is that of patients operated on acutely for suspected appendicitis within 10 years in one medical center. patients undergoing interval or incidental appendectomies will not be included. the endpoint to be evaluated is complicated appendicitis (gangrenous, abscess, perforated). the independent variables will include mainly sex, age, patient time (time from symptom onset to registration), hospital time (time from registration to operation), and missed diagnosis.

Eligibility criteria:
inclusion criteria: * male and female patients of all ages who underwent appendectomy of acute appendicitis in a single medical center between december 1, 2006, and december 31, 2016 exclusion criteria: * interval appendectomy, * incidental appendectomy, * appendectomy after failed antibiotic treatment for either acute appendicitis or peri-appendicular abscess * patients with a non-inflamed appendix * those in whom symptom onset before hospitalization was not noted.

Keywords: appendicitis ruptured appendicitis appendectomy timing of surgery
dimebon (pf-01913539)-digoxin drug-drug interaction study in healthy subjects

Conditions: Alzheimer Disease; Huntington Disease

Summary: this study has been designed to confirm, in healthy subjects, the lack of a clinically important pharmacokinetic interaction between dimebon, at the proposed maximum commercial dose of 20 mg tid (administered every 8 hours), and digoxin (lanoxin®) 0.125 mg qd, a sensitive p-gp substrate recommended by fda.


Eligibility criteria:
inclusion criteria: * healthy male and/or female subjects between the ages of 18 and 55 years, inclusive (healthy is defined as no clinically relevant abnormalities identified by a detailed medical history, full physical examination, including blood pressure and pulse rate measurement, 12-lead ecg and clinical laboratory tests). * body mass index (bmi) of 17.5 to 30.5 kg/m2; and a total body weight \>50 kg (110 lbs). exclusion criteria: * a known history of hypersensitivity or previous intolerance to dimebon or digoxin. * evidence or history of clinically significant hematological, renal, endocrine,pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or allergic disease (including drug allergies, but excluding untreated, asymptomatic,seasonal allergies at time of dosing) disease or clinical findings at screening. * pregnant or nursing women; women of childbearing potential (wocbp) who are unwilling or unable to use an acceptable method of contraception as outlined in the protocol from at least 14 days prior to the first dose of study medication.

Keywords: digoxin dimebon drug-drug interaction study
twice daily titration study of bifeprunox in subjects with schizophrenia

Conditions: Schizophrenia; Schizoaffective Disorder

Summary: this study is to assess the safety and tolerability of a five-day titration schedule (using twice daily dosing for the first three days) to achieve the highest proposed dose of 40 mg daily. the study duration is two months.


Eligibility criteria:
inclusion criteria: * subjects who have current diagnosis of schizophrenia or schizoaffective disorder * body weight of 100-250 lbs * male or females * 18-55 years of age exclusion criteria: * subjects who are acutely psychotic * subjects with current axis i primary psychiatric diagnosis other than schizophrenia, at significant risk of suicide

Keywords: titration study schizophrenia bid dosing pharmacokinetic
two dose schedules of panitumumab in subjects with advanced solid tumors

Conditions: Tumors; Oncology; Solid Tumors

Summary: the purpose of this study is to evaluate the safety and pharmacokinetics of two dose schedules of panitumumab in subjects with advanced solid tumors.


Eligibility criteria:
inclusion criteria: * pathologic diagnosis of advanced solid tumors that are refractory to at least 1 standard therapy or for which no standard therapy is available and have not received more than 3 prior treatment regimens (not inclusive of hormonal therapies for breast and prostate cancer subjects) for the advanced solid tumor (tumor must be diagnosed by standard criteria for the specific tumor type) * measurable disease or evaluable (non-measurable) disease per recist guidelines (all sites of disease must be evaluated within 28 days before enrollment) * eastern cooperative oncology group (ecog) performance status of 0 or 1 * life expectancy of \> 3 months as documented by the investigator * if history of other primary cancer, subject will be eligible only if she or he has: * non-melanomatous skin cancer, not requiring treatment * curatively treated cervical carcinoma in situ * other primary solid tumor curatively treated with no known active disease present for the last 5 years and no treatment administered for the last 3 years * man or woman 18 years of age or older * paraffin-embedded tumor tissue (from primary or metastatic tumor tissue) available for immunohistochemistry studies of egfr expression (biopsy or archived tissue are acceptable). the immunohistochemical egfr staining and evaluation must be conducted at the designated central laboratory using the dakocytomation egfr pharmdxtm kit. local laboratory egfr expression is not permitted for the purpose of eligibility in this study * hematologic function, as follows: * absolute neutrophil count (anc) \> 1.5 x 109/l * platelet count \> 100 x 109/l * hemoglobin \> 8 g/dl * renal function, as follows: o creatinine \< 2.0 mg/dl * hepatic function, as follows: * aspartate aminotransferase (ast) \< 3 x uln (if liver metastases ≤ 5 x uln) * alanine aminotransferase (alt) \< 3 x uln (if liver metastases ≤ 5 x uln) * bilirubin \< 2 x uln * competent to comprehend, sign, and date an iec/irb-approved informed consent form

Keywords: targeted therapy solid tumors abx-egf, panitumumab egfr immunex, abgenix, amgen monoclonal antibody
effectiveness of internet-based self-help cognitive behavioural therapy in reducing insomnia among adult population

Conditions: Insomnia

Summary: this experimental study aims to develop an internet-based self-help cognitive behavioural therapy for insomnia that reduces insomnia symptoms and its associated adverse outcomes among people with sub-threshold insomnia symptoms. in particular, this study compares the efficacy of internet-delivered self-help cbt-i with the wait-list control group, in treating insomnia in a non-clinical population. the online cbt-i course will consist of an introductory module, followed by 6 weekly modules. each module will consist of the main treatment component presented in written or video format, quiz, and homework. materials will be presented in an interactive manner to facilitate engagement.

although the internet self-help crt-i program have shown promising effect on dealing with insomnia symptoms, the effectiveness of internet self-help cbt-i in adults with sub-clinical insomnia symptoms in hong kong is under-studied. therefore, the present study aimed to compare the efficacy of internet-delivered self-help cbt-i with the wait-list control group, in treating insomnia in a non-clinical population. we hypothesized that (1) participants who received cbt-i treatment would have improved insomnia symptoms after the intervention as compared with the wait-list controls; (2) participants from cbt-i would have better sleep hygiene, and less dysfunctional beliefs about sleep and pre-sleep arousal after the intervention as compared with the wait-list controls; (3) participants from cbt-i would have improved mental health, daytime functioning, quality of life, and general well-being after treatment, as compared with the wait-list controls. the online cbt-i course will consist of an introductory module, followed by 6 weekly modules, incorporating the key cbt-i components, including sleep hygiene education, stimulus control, sleep restriction, relaxation training, and cognitive therapy. each module will consist of the main treatment component presented in written or video format, quiz, and homework. materials will be presented in an interactive manner to facilitate engagement.

Eligibility criteria:
inclusion criteria: * hong kong residents * age ≥18 years * insomnia severity index score \> 7 and \< 22 * being able to read chinese * have a computer, tablet and/or smartphone device with internet access * have a regular email address * willing to give informed consent and comply with the trial protocol exclusion criteria: * receiving psychological treatment at least once per month * currently taking prescribed psychiatric drugs such as antidepressants, tranquilizers, and sleeping pills regularly * carrying a diagnosis of psychosis or schizophrenia * participating in any other academic studies or clinical trials related to insomnia * having current suicidal plans or acts or having had suicidal plans or acts within the past 12 months * shift workers

Keywords: cognitive behavioural therapy
safety, pharmacokinetics and pharmacodynamics of dsp-8658 in patients with type 2 diabetes mellitus and healthy adults

Conditions: Type 2 Diabetes Mellitus

Summary: the purpose of this study is to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of multiple ascending doses of dsp-8658 in patients with type 2 diabetes mellitus and healthy adults.


Eligibility criteria:
inclusion criteria: diabetic subjects * age ≥ 18 and ≤ 65 years * body mass index ≤45 * drug naive type 2 diabetes or type 2 diabetes previously treated with an oral antidiabetic drug inclusion criteria: healthy subjects * age ≥ 18 and ≤ 65 years * body mass index ≥ 18 and ≤ 29 * good health as determined by medical history, ecg, clinical chemistry, hematology, urinalysis, virology, and a physical examination. exclusion criteria: diabetic subjects * have a current or expected requirement for any antidiabetic or lipid-lowering drug exclusion criteria: healthy subjects * have, or have had a history of clinically significant neurological, urological, gastrointestinal, renal, hepatic, cardiovascular, psychological, pulmonary, metabolic, endocrine, hematological, or other major disorders including cancer

Keywords: diabetes
hi-chart:feasibility of high-dose accelerated conformal radiotherapy

Conditions: Non-Small-Cell Lung Carcinoma

Summary: in this study we try to increase the radiation dose, while reducing or keeping the radiation schedule below 4 weeks. the study hypothesis is that it is feasible to administer hyperfractionated accelerated radiotherapy to patients with inoperable or locally advanced non small cell lung cancer.

non-small cell lung cancer is still the most common cancer and the main cause of cancer death. treatment of choice for these patients is often radiotherapy, which results in an overall 5-year survival rate between 5 and 10%. the addition of chemotherapy improves survival by a few percentages and is therefore considered standard treatment for patients with stage iii disease. however, several factors have been identified that have an impact on the local control but also on survival. 1. there is a dose-effect relationship. a higher dose results in a better survival rate. however, higher radiation doses are currently not delivered with conventional radiation due to the tolerance of normal tissue. 2. the time factor plays an important role in radiotherapy. prolonging the overall treatment time decreases the outcome of radiotherapy. radiobiological modelling of data shows that the overall treatmetn time (ott) should be kept below 4 weeks. results from studies support this conclusion. so, probably the best results will be achieved when a very high radiation dose can be delivered within 4 weeks, without severally damaging normal tissue. in order to achieve this goal, an hyperfractionated accelerated treatment regimen together with a technically very advanced radiation technique to avoid as much normal tissue as possible, will be used in this study.

Eligibility criteria:
inclusion criteria: histological or cytological diagnosis of non-small cell lung cancer stage i-iii disease, except supra-clavicular lymph nodes availability for participating in the detailed follow-up of the protocol able to tolerate a radiation course according to the protocol guidelines in case of previous chemotherapy, radiotherapy can start after a minimum of 3 weeks after the last ct course good performance status: karnofsky\>=70%, who performance status 0-2 adequate lung functions allowing the radiation according to the guidelines protocol no severe recent cardiac disease absence of any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule; conditions should be discussed with the patient before registration in the trial - exclusion criteria: patients who have a peripherally located lower lobe tumor and contralateral upper mediastinal nodes malignant pleural or pericardial effusion concurrent chemotherapy programs history of a prior malignancy excluding non melanoma skin cancer or in-situ cancer history of prior chest irradiation recent myocardial infraction uncontrolled infectious disease distant metastases (stage iv) -

Keywords: radiotherapy radiation dose lung cancer
fascial closure technique after gynecologic laparoscopic surgery and postoperative pain

Conditions: Pain, Postoperative

Summary: our study aims to determine postoperative pain outcomes when comparing port site \> 10 mm fascial closure with traditional direct closure versus use of laparoscopic fascial closure device in patients undergoing minimally invasive gynecologic surgery via laparoscopic or robotic techniques. pain outcomes will be measured using the visual analog scale.


Eligibility criteria:
inclusion criteria: * patients aged 18 or older. * any patient undergoing laparoscopic gynecologic surgery with one left upper quadrant port site \> 10 mm via either robotic or traditional laparoscopic techniques for any indication including abnormal bleeding, pelvic pain, gynecologic cancer, uterine fibroids, etc. procedures performed will include but not be limited to hysterectomy, bilateral or unilateral salpingoophorectomy, ovarian cystectomy, and pelvic floor support procedures. * patients willing and able to give informed consent. * patients capable and willing to return for follow up and complete pain diaries. exclusion criteria: * patients unable to return for follow up. * patients undergoing laparoscopic surgery that requires conversion to laparotomy. * patients undergoing laparoscopic surgery that does not require a port site \>10 mm.
effect of emst systemic inflammation and oxidative stress in patients with moderate osas

Conditions: Obstructive Sleep Apnea; Oxidative Stress; Respiratory Muscle Training

Summary: it was aimed to investigate the effect of expiratory muscle strength training (emst) applied at different intensities on systemic inflammation and oxidative stress in patients with moderate obstructive sleep apnea syndrome (osas). in the study, 32 male patients diagnosed with moderate osas will be included in the study. participants will then be divided into 2 groups by block randomization. in the three-blind planned study; the first group will receive high-intensity %60 maximum expiratory pressure (mep) emst training, and the second group will be given low-intensity 30% of mep, emst training for 12 weeks. disease-related symptoms, disease severity apnea-hypopnea index (ahi), oxidative stress index (osi) and systemic inflammation level, exercise capacity, respiratory muscle strength, sleep quality, daytime sleepiness, and fatigue severity will be evaluated before and after the study.

primary outcome measures are; disease severity, oxidative stress index and systemic inflammation. secondary outcome measurements are; disease-related symptoms, exercise capacity, respiratory muscle strength, sleep quality, daytime sleepiness, and severity of fatigue.

Eligibility criteria:
inclusion criteria: 1. male patients diagnosed with moderate osas by polysomnography in the sleep center of ahi evren thoracic and cardiovascular surgery training and research hospital, 2. those who are between 19-60 years old, 3. stable general health status, 4. volunteer to participate in the research, 5. not using nimv device, 5) patients who do not have a mental problem that will prevent cooperation will be included. exclusion criteria: 1. female gender, 2. having a previous stroke, 3. having an overlap syndrome, 4. having any neurological, psychological or cardiac disease, 5. uncontrolled hypertension and high blood glucose levels, 6. severe obstructive nasal disease, 7. history of previous oropharyngeal surgery 8. having a body mass index of 40 kg/m2 or more, 9. using drugs, alcohol, sedative and hypnotic drugs, 10. having a cognitive problem

Keywords: obstructive sleep apnea oxidative stress
dry needling and electromyographic changes in neck pain

Conditions: Neck Pain

Summary: there is evidence suggesting that patients with mechanical neck pain exhibit higher activity of the superficial neck flexor muscles during the execution of the cranio-cervical flexion test. in addition, some studies have reported the presence of active trigger points in the neck flexor and extensor muscles. since preliminary evidence suggests that trigger points can affect motor control behaviour, it is possible that management of these trigger points with dry needling could be effective for improving muscle activity during low-load activities, such as the cranio-cervical flexion test. therefore, the aim of this study will be to investigate the effects on electromyographical activity, pressure pain thresholds and cervical range of motion after the application of dry needling over active trps in the upper trapezius muscle in patients with mechanical neck pain.


Eligibility criteria:
inclusion criteria: generalized neck-shoulder pain with symptoms provoked by neck postures, neck movement, or palpation of the cervical musculature. exclusion criteria: * whiplash injury; * previous cervical or thoracic surgery; * cervical radiculopathy or myelopathy; * diagnosis of fibromyalgia syndrome; * having undergone physical therapy in the previous 6 months; * less than 18 or greater than 55 years of age * fear to needles

Keywords: neck pain trigger points dry needling cranio-cervical flexion test
manual therapy, exercise and traction for patients with cervical radiculopathy: a rct

Conditions: Cervical Radiculopathy

Summary: to date, optimal strategies for the management of patients with cervical radiculopathy (cr) remain elusive. the purpose of this study was to compare the effects of manual therapy, exercise, and cervical traction to manual therapy, exercise, and sham traction on pain, function and disability in patients with cr.


Eligibility criteria:
inclusion criteria: * 3 of 4 positive on cpr, 18-70yrs exclusion criteria: * history of previous cervical or thoracic spine surgery * bilateral upper extremity symptoms * signs or symptoms of umn disease * medical "red flags"(tumor, fracture, rheumatoid arthritis, osteoporosis, prolonged steroid use) * cervical spine injections (steroidal) in the past two weeks * current use of steroidal medication prescribed for their radiculopathy symptoms

Keywords: manual therapy, cervical traction, cervical radiculopathy
prospective cohort study of arthroscopic treatment of hip dysplasia

Conditions: Developmental Dysplasia of the Hip

Summary: on the basis of the database established in the previous stage, a cohort analysis was conducted on patients with bddh complicated by hip arthroscopy for minimally invasive treatment of glenoid and lip injury, according to which the indications of minimally invasive surgery for bddh patients were optimized and surgical measures were improved. achieve accurate and rapid repair, rehabilitation and functional recovery, serve national fitness, and treat people's injuries

based on the work of the previous research group, we prospective constructed a bidirectional cohort of patients with critical hip dysplasia, and summarized the influencing factors for the surgical prognosis of patients with bddh, so as to continuously optimize patient selection. on this basis, the cohort size was extended to analyze the difference in efficacy between arthroscopic glenolabial repair and glenolabial repair combined with soft tissue enhancement, and further improve the minimally invasive surgery to promote the efficacy of minimally invasive surgery in bddh patients

Eligibility criteria:
inclusion criteria: - diagnosis of borderline hip dysplasia with glenolabial injury. exclusion criteria: -