Kornimate/medical-research-clean huggingface dataset:
the optimal timing of the initiation of esophagogastroduodenoscopy after oral lidocaine spray

Conditions: Blood Pressure; Tachycardia

Summary: esophagogastroduodenoscopy (egd) is the main examination in the upper gastrointestinal field. aspiration pneumonia may happen if choking occurs during the egd insertion, and the exam quality and efficacy may be affected if gag reflex occurs. the endoscopist may terminate the exam to avoid complications if the patient could not obey the orders. to reach the high quality of egd examination and to avoid possible complications, the patient's comfort and compliance during the egd examination are important. sedation using propofol can improve the patient's comfort and compliance. however, in patients unsuitable for systemic anesthesia, local lidocaine spray at pharynx is performed instead. until now, there is no standardization of the waiting time between lidocaine spray and the initiation of egd. this study aimed to investigate the optimal timing of the initiation of esophagogastroduodenoscopy after lidocaine spray.

this study compares the 1-minute waiting time and 3-minute waiting time between the lidocaine spray and the egd initiation. during the topical anesthesia stage, investigators give local spray with 6 puff on pharynx at the 0 minute in both groups. after the waiting time, egd is inserted. the baseline heart rate and blood pressure were recorded before egd and during the egd passing through pharynx respectively. after the whole procedure, enrolled patients will fill in the egd quality questionnaire. through this study, investigators can figure out whether 1 minute or 3 minutes may be the optimal waiting time after lidocaine spray.

Eligibility criteria:
inclusion criteria: * eligible participants included patients aged ≥ 20 years who scheduled egd from opd for dyspepsia, peptic ulcer disease, gerd, subepithelial lesion evaluation, and diarrhea exclusion criteria: * gi bleeding * endoscopic submucosal dissection due to prolonged scheduled procedure time * patients from emergency department or ward
early changes among flex, lasik and fs-lasik

Conditions: Myopia; Astigmatism

Summary: to evaluate the short-term changes in ocular surface measures and tear inflammatory mediators after lenticule extraction (flex), laser in situ keratomileusis (lasik) and femtosecond laser-assisted laser in situ keratomileusis (fs-lasik) procedures.

laser in situ keratomileusis (lasik) with a microkeratome has been accepted wildly in the past 20 years. gradually, laser in situ keratomileusis with a femtosecond laser-created flap (fs-lasik)has been a popular ophthalmic procedure for the correction of refractive error. this first all-in-one fs-laser system was designed to perform the refractive lenticule extraction (relex) procedures, femtosecond lenticule extraction (flex).they have the same feature: corneal flap. ocular surface disruption during corneal refractive surgery is commonly considered to be closely related to the development of dry eye. multiple etiologies contribute to this ocular surface disruption, including the flap creation and stromal ablation involved in previous refractive surgery techniques. corneal nerve damage has been considered the main cause of dry eye, due to disrupted afferent sensory nerves, reduced blink reflex, and increased tear evaporation leading to tear film instability. in addition, postoperative inflammatory mediator fluctuations are also a key factor related to ocular surface damage. extensive research has described the effects of cytokines, chemokines and growth factors in modulating corneal wound healing, cell migration, and apoptosis on the ocular surface after refractive surgery. this prospective clinical study is going to analyze the short-term changes in ocular surface measures and tear inflammatory mediators after flex, lasik and fs-lasik procedures.

Eligibility criteria:
inclusion criteria: * minimum age of 18 years(range from 18 year to 31 years); corneal thickness 500 μm with calculated residual stromal bed after treatment greater than 300 μm; preoperative spherical equivalent refraction between * 2.00 diopter (d) and -6.50 d; preoperative cylindrical equivalent refraction between -0.25 d and -1.50 d; preoperative corneal curvature from 42.0 d to 46.0 d with a regular topographic pattern, verified with an atlas topographer; monocular best corrected visual acuity of 20/20 or better and stable refractive error (less than 0.5 d change) for 24 months before surgery exclusion criteria: * systemic disease that contraindicated the surgery (such as diabetes, glaucoma and systemic collagen vascular disease); corneal abnormality or disease; a history of tear supplement usage or contact lens wear during the past year

Keywords: lenticule extraction laser in situ keratomileusis femtosecond laser-assisted laser in situ keratomileusis tear inflammatory mediators
the latarjet-type procedure using the sem positioner: using a scan to assess consolidation

Conditions: Shoulder Dislocation

Summary: the main objective of this study is to evaluate, after surgery for chronic anterior shoulder instability using a latarjet technique with positioning of the bone block via an sem positioning tool, the value of the contribution of a shoulder scan at 3 months post surgery in the decision to return to activity early as conditioned by the quality of the bone block consolidation.

the secondary objectives of this study are to assess: a. the position of the block according to a shoulder scan at 3 months post-surgery b. functional scores (constant, walch-duplay) at 6 weeks, 3 and 6 months post surgery. c. complications: osteoarthritis, lysis of the block. d. pain. e. date of return to full activity. f. patient satisfaction concerning care (visual analog scale at 6 months post-surgery).

Eligibility criteria:
inclusion criteria: * the patient must have given his/her informed and signed consent * the patient must be insured or beneficiary of a health insurance plan * the patient was operated for chronic anterior shoulder instability (defined by a history of at least two true dislocations and an isis score\> 2) 6 weeks ago (+/- 5 days) exclusion criteria: * the patient is participating in another study * the patient is in an exclusion period determined by a previous study * the patient is under judicial protection, under tutorship or curatorship * the patient refuses to sign the consent * it is impossible to correctly inform the patient * the patient is pregnant, parturient, or breastfeeding
physical activity in relation to surgical procedures

Conditions: Colorectal Cancer; Surgery

Summary: this study will compare the outcome after surgery between a group of patients that receives instructions for prehabilitation training and one group that received standard treatment.

the aim of this study is to investigate whether a training program with intensified physical activity prior to and after a surgical procedure reduces the surgical-related postoperative recovery time, hospital stay, sick leave and complication rate. a secondary aim is to investigate the effect of a training program with pre- and post- operative pa on the rate of resumption of qol and normal physical function.

Eligibility criteria:
inclusion criteria: * diagnosed colorectal cancer and a planned surgical procedure exclusion criteria: * hipec surgery, not able to give informed consent or understand the intervention

Keywords: colorectal neoplasm physical activity
predictive variables of outcome in subjects with chronic rachialgia referred to different pathways of physiotherapy.

Conditions: Chronic Non-Specific Low Back Pain; Chronic Non-specific Neck Pain

Summary: the aim of this study is to investigate the predictive value of various biopsychosocial variables on the outcomes of subjects with chronic spinal pain undergoing public health rehabilitation pathways. secondly, the study aims to assess the reliability of certain questionnaires, classified as patient-reported outcome measures (proms), which are frequently used in the evaluation of spinal pain but whose metric properties have not yet been established. these objectives will be pursued through two comprehensive assessment sessions (before and after rehabilitation), a re-test session immediately before rehabilitation (to evaluate the reliability of the questionnaires in stable subjects), and two follow-up assessments at 3 and 6 months after discharge.


Eligibility criteria:
inclusion criteria: * age of majority; * medical diagnosis of nonspecific low back pain or nonspecific neck pain; * chronic symptoms, present for at least 6 months; * waiting for rehabilitation in a public health pathways * signature of informed consent to participate in the study and processing of personal data. exclusion criteria: * subjects with cognitive impairment
circulating epigenetics in pancreatic surgery

Conditions: Pancreatic Neoplasms

Summary: the overall objective of the study is to assess dna-methylation changes in circulating blood cells and cell free dna in plasma from patients undergoing the whipples procedure for pancreatic caner


Eligibility criteria:
inclusion criteria: * patients with pancreatic cancer scheduled for the whipples procedure exclusion criteria: * under 18 years of age * pregnancy * unable to provide informed consent.
the measurement of insulin resistance in peritoneal dialysis patients

Conditions: End Stage Renal Disease

Summary: the goal of this study is to examine the relevance of insulin resistance in peritoneal dialysis (pd) patients as well as the means to improve this metabolic derangement. we will do so through a prospective randomized study using icodextrin as an alternate dialysate solution to routine glucose-based dialysate. we hypothesize that (1) the glucose loading associated with pd leads to impairment in insulin sensitivity, (2) the degree of insulin resistance is dependent on the basal metabolic state (fasting versus stimulated), and (3) the replacement of conventional dialysate with glucose-sparing dialysate preparations will improve insulin resistance and associated metabolic disturbances in pd patients.


Eligibility criteria:
inclusion criteria: * medically stable and receiving stable pd for ≥ 3 months; * bmi ≤ 45; * most recent kt/v ≥1.7 or tccr ≥ 50l/week/1.73m2; * on glucose lactate-buffered pd solutions with consistent glucose exposure. exclusion criteria: * pregnancy or breast-feeding; * intolerance to the study protocols; * severe, unstable, active, or chronic inflammation disease (active infection, active connective tissue disorder, active cancer, hiv, liver disease); * chronic use of anti-inflammatory medication except low dose (\< 10mg/d) prednisone; * severe hypokalemia (k+ level \< 3.0 meq/l); * hypercalcemia (ca++ level \> 11.0 mg/dl); * have a glycogen storage disease; * intolerant to maltose or isomaltose; * allergic to cornstarch or icodextrin; * recent abdominal surgery in the past 30 days; * chronic obstructive lung disease (copd) or interstitial lung disease; * insulin-dependent diabetes mellitus (iddm).

Keywords: peritoneal dialysis insulin resistance
a retrospective review of the seasonality of pre-eclampsia

Conditions: Preeclampsia

Summary: this retrospective review will will attempt to determine whether our data show a significant difference in number of deliveries of women with pre-eclampsia compared to deliveries without pre-eclampsia during certain months of the year.

this study is a retrospective review of obstetrics charts of women who gave birth at osu medical center between january 01, 2005 and december 31, 2007. included will be patient charts of women \> 18 years old who were admitted to osumc for delivery (both cesarean and vaginal deliveries) between 1/1/05 and 12/31/07, with and without a diagnosis of pre-eclampsia. the data collected will be recorded in a spreadsheet by month/day of delivery, and whether pre-eclampsia was a diagnosis. also included will be total number of deliveries per month and total number of pre-eclampsia diagnoses per month. the rate of pre-eclampsia will be calculated. a contingency table with corresponding chi square test will be performed to determine whether there is a significant relationship of the diagnosis of pre-eclampsia with seasonality, defined primarily by month. certain data occurring during transition periods between seasons may be excluded from analyses.

Eligibility criteria:
inclusion criteria: * women who gave birth at osu medical center between january 01, 2005 and december 31, 2007 and were \> 18 years old who were admitted to osumc for delivery (both cesarean and vaginal deliveries) between 1/1/05 and 12/31/07, with and without a diagnosis of pre-eclampsia. exclusion criteria: * females under age 18

Keywords: preeclampsia
intraoperative peep setting during laparoscopic gynecologic surgery

Conditions: Positive-Pressure Respiration/Methods; Esophagus/Physiopathology; Pleura/Physiopathology; Gynecologic Surgical Procedures; Laparoscopy; Humans; Female

Summary: the creation of pneumoperitoneum during laparoscopic surgery can have significant effects on the respiratory system including decreased respiratory system compliance, decreased vital capacity and functional residual capacity and atelectasis formation. intraoperative mechanical ventilation, especially setting of positive end-expiratory pressure (peep) has an important role in respiratory management during laparoscopic surgery. the aim of this study is to determine whether setting of peep guided by measurement of pleural pressure would improve oxygenation and respiratory system compliance during laparoscopic surgery.

as minimally invasive procedure with numerous advantages compared with open surgery, laparoscopic surgery has been substantially performed worldwide. the creation of pneumoperitoneum during laparoscopic surgery, however, can have significant effects on the respiratory system including decreased respiratory system compliance, decreased vital capacity and functional residual capacity and atelectasis formation. these pathophysiologic changes may put patients at risk of postoperative pulmonary complications. therefore, intraoperative mechanical ventilation, especially setting of positive end-expiratory pressure (peep) has an important role in respiratory management during laparoscopic surgery. nevertheless, there is no consensus on the optimal peep level and the best method to set peep during laparoscopic surgery. in patients with acute respiratory distress syndrome, peep set according to pleural pressure measured by using esophageal balloon catheter significantly has beneficial effects in terms of oxygenation, compliance and possible mortality. the aim of this study is to determine whether setting of peep guided by measurement of pleural pressure would improve oxygenation and respiratory system compliance during laparoscopic surgery.

Eligibility criteria:
inclusion criteria: * patients with age of equal or more than 18 years old undergoing laparoscopic gynecologic surgery with anticipated surgical duration of more than 2 hours exclusion criteria: * patients with asa physical status of equal or more than 3 * patients with significant cardiovascular or respiratory diseases * patients with significant pathological lesion in pharynx and esophagus that preclude placement of esophageal balloon catheter * patients with contraindications for peep titration such as increased intracranial pressure or unstable hemodynamic * patients with arrhythmias * patients who refuse to provide written informed consent * patients undergoing surgery with duration of less than 2 hours

Keywords: intraoperative mechanical ventilation positive-end expiratory pressure esophageal pressure transpulmonary pressure laparoscopic gynecologic surgery
prostatic artery embolization for the treatment of lower urinary tract symptoms in prostate cancer patients undergoing radiation therapy

Conditions: Prostate Cancer

Summary: the purpose of this study is to learn if the prostatic artery embolization procedure can reduce urinary tract symptoms in patients with enlarged prostates and prostate cancer.

primary objective 1. to evaluate the symptomatic improvement in lower urinary tract symptoms after prostatic artery embolization (pae) secondary objectives 1. to evaluate objective measures of improved urinary obstruction after pae: urine flow rate, prostate volume, and post-void residual 2. to measure effects of pae on prostate specific antigen (psa). 3. to evaluate if pae reduces the prostate volume and simplifies radiation therapy 4. to evaluate the safety of pae performed in this patient population

Eligibility criteria:
inclusion criteria: * age ≥ 40 years and ≤ 90 years old * prostate volume ≥ 40 ml and ≤ 300 ml * biopsy proven prostate cancer undergoing radiation therapy * diagnosis of moderate to severe lower urinary tract symptoms (luts) defined as at least one of the following: 1. ipss ≥ 12 or dependent on urinary catheterization, or 2. ipss quality of life (qol) assessment ≥ 3, and 3. qmax ≤ 12 ml/sec * ability to understand and willingness to sign the written consent exclusion criteria: * neurogenic bladder disorder due to multiple sclerosis, parkinson's disease, spinal cord injury, diabetes, etc., as demonstrated on urodynamic testing. * detrusor muscle failure, urethral stenosis, or urinary obstruction due to causes other than prostatic obstruction, as demonstrated on urodynamic testing * bladder diverticula greater than 5 cm or bladder stones greater than 2 cm * other active urogenital cancer * baseline serum creatinine greater than 2 mg/dl * evidence of tortuous or atherosclerotic blood vessels * coagulation disturbances not normalized by medical treatment * allergy to iodinated contrast agents not responsive to steroid premedication regimen

Keywords: prostatic artery embolization lower urinary tract symptoms
cbt to treat depression in renal patients

Conditions: Depression; End Stage Renal Disease

Summary: the purpose of this study is to determine whether cognitive behavioral therapy is effective in the treatment of depression in patients with end-stage renal disease in hemodialysis therapy

depression is a persistent problem among patients with end-stage renal disease and it does not tend to improve over time. the implementation of effective interventions to treat and prevent recurrence of depressive episodes is needed. the objectives of this study are: 1)the detection of major depression in hemodialysis patients; 2)to allocate patients with depression in two groups: structured program of treatment with cbt (group therapy)and control group (conventional psychotherapy at the dialysis unit); and 3)to verify whether after 3 months of cbt there was a remission of depressive symptoms and a improvement of the quality of life in the cbt group.

Eligibility criteria:
inclusion criteria: * patients with a diagnosis of chronic renal disease (end stage) in hemodialysis for at least 3 months * diagnosis of major depression disorder (4 or more clinical criteria in mini and a bdi score of 10 or more) exclusion criteria: * patients in process of renal transplant with (living donor) * psychiatric comorbidity * cognitive impairment or mental retardation * current substance abuse * heart failure, angina pectoris, arrhythmias

Keywords: depression end stage renal disease quality of life cognitive behavioral therapy
a phase 1, dose finding study of cc-90002 in subjects with advanced solid and hematologic cancers

Conditions: Hematologic Neoplasms

Summary: cc-90002-st -001 is an open-label, phase 1, dose escalation clinical study in subjects with advanced, refractory solid and hematologic cancers.

cc-90002-st-001 is an open-label, phase 1, dose escalation, first in human (fih) clinical study of cc-90002, administered by intravenous (iv) infusion, in subjects with advanced, refractory solid and hematologic cancers. the study will be conducted in two parts. part a dose escalation phase will explore escalating dose cohorts of the study drug cc-90002. part b dose escalation will explore escalating doses of cc-90002 in combination with rituximab in subjects with cd20-positive nhl.

Eligibility criteria:
inclusion criteria: 1. men and women, 18 years or older, with advanced, relapsed or refractory solid tumors, multiple myeloma (mm) or non-hodgkin's lymphoma (nhl) in part a. in part b, relapsed and/or refractory cd20-positive nhl subjects only. 2. at least one site of measurable disease in subjects with solid tumors and nhl. 3. eastern cooperative oncology group performance status (ecog ps) of 0 or 1. 4. subjects must have adequate hematopoietic, liver, renal and coagulation function as assessed by specific laboratory criteria. 5. females and males must agree to contraceptive methods and avoid conceiving throughout the study, and for up to 8 weeks following the last dose of cc-90002. if participating in part b, females of child bearing potential should continue to use effective contraceptive methods for 12 months following treatment with rituximab exclusion criteria: 1. high grade lymphomas (burkitts or lymphoblastic), plasma cell leukemia. 2. high grade, rapidly proliferative solid tumors (eg, small cell lung cancer, germ cell tumors, neuroblastoma) with extensive tumor burden. 3. symptomatic central nervous system involvement. 4. impaired cardiac function or clinically significant cardiac disease. 5. prior red blood cell (rbc) transfusion \< 3 months prior to starting cc-90002 (part a only). 6. prior autologous stem cell transplant ≤ 3 months prior to starting cc-90002. 7. prior allogeneic stem cell transplant with either standard or reduced intensity conditioning ≤ 6 months prior to starting cc-90002. 8. prior systemic cancer-directed treatments or investigational modalities ≤ 5 half lives or 4 weeks prior to starting cc-90002, whichever is shorter. 9. major surgery ≤ 2 weeks prior to starting cc-90002. 10. pregnant or nursing females. 11. known hiv infection. 12. known chronic, active hepatitis b or c (hbv/hcv) infection. 13. ongoing treatment with chronic, therapeutic dosing of anti-coagulants. 14. history of autoimmune hemolytic anemia or autoimmune thrombocytopenia. 15. history of concurrent second cancers requiring active, ongoing systemic treatment. concurrent second cancers requiring active, ongoing systemic treatment.

Keywords: cc-90002 monoclonal antibody cd47 advanced solid cancers hematologic cancers
safety of cenobamate in japanese subjects with partial onset seizures

Conditions: Epilepsies, Partial

Summary: to evaluate the long-term safety and tolerability of cenobamate in japanese epilepsy patients with partial seizures


Eligibility criteria:
inclusion criteria: * subjects completed study ykp3089c035 by sk life science. exclusion criteria: * subjects that have previously discontinued for any reason from the core study (ykp3089c035). * any significant changes to the medical history of the subject that in the opinion of the investigator, could affect the safety of the subject.
services mapping among older adults with hip fracture

Conditions: Hip Fractures

Summary: hip fracture is a osteoporosis-related fracture with higher mortality, and is a major public health issue in china. the british orthopedic association and the british geriatric society have published the uk blue book, which summarizes current evidence and best practice in the hip fracture care and secondary prevention, but this kind of standardized practice in hip fracture care is not yet existed in china. the blue book standards will be used as the most contemporary evidence-based guidelines for management of hip fracture.this study is to prospectively examine the barriers and facilitators in the current management of hospital in china by comparing the blue book standards.


Eligibility criteria:
inclusion criteria: * adults aged 65 years old or over; * hip fracture with x-ray-confirmed femoral neck, trochanteric or sub-trochanteric fracture; * within 21 days of a hip fracture; * willingness to sign informed consent form; exclusion criteria: * patients with pathological fractures; * with terminal malignancies.