Kornimate/medical-research-clean huggingface dataset:
effect of transcutaneous electrical nerve stimulation versus capsicum plaster on emesis gravidarum

Conditions: Emesis Pregnancy

Summary: this study will be conducted to determine the difference between the effect of transcutaneous electrical nerve stimulation and capsicum plaster on emesis gravidarum.

almost 50-90% of pregnant women experience nausea vomiting in the first trimester. nausea vomiting occurs in 60% -80% primigravida and 40% -60% in multigravida.it is revealed that 50% of affected women have a significant reduction of their work efficiency. transcutaneous acupoint electrical stimulation (taes) at the nei-guan p6 acupoint may be a useful alternative to antiemetic drugs. it is effective in the treatment of both motion sickness and pregnancy induced nausea and vomiting , as well as emesis associated with chemotherapy. capsicum plaster is an alternative to acupuncture. it is applied to the acupuncture points and has been reported to be an effective method for preventing postoperative nausea and vomiting (ponv), postoperative sore throat, and postoperative pain.

Eligibility criteria:
inclusion criteria: * pregnant women complaining of emesis gravidarum * their ages will be ranged from 20 to 35 years old. * their body mass index will not exceed 35 kg/ m2. * their gestational age will be less than 20 weeks. * all women having mild to moderate nausea and/or vomiting * all women having singleton pregnancy exclusion criteria: women will be excluded from the study if they have: * previous carpal tunnel syndrome. * skin abnormalities * acute viral disease * hyperemesis gravidarum. * previous history of nausea or vomiting before pregnancy.
breakfast and energy expenditure in young women

Conditions: Obesity

Summary: the purpose of this research is to determine if body composition influence the effect of breakfast composition on postprandial (post-meal) hunger, metabolic and energy expenditure response in normal weight, overweight, and obese young women.


Eligibility criteria:
inclusion criteria: * bmi over 18.5 * no medication exclusion criteria: * food allergies * habitual breakfast skipping (\> 5 times per week) * picky eater * dietary restrictions
smart-phone safety behavior fading intervention for appearance concerns (open arsb study)

Conditions: Body Dysmorphic Disorder; Social Anxiety Disorder; Eating Disorders

Summary: the current study aims to explore the efficacy of a text message based safety behavior fading intervention compared to a relaxing video intervention for appearance concerns.

description: appearance-related safety behavior fading intervention procedures will follow methodology previously used in the cougle lab. the safety behavior fading intervention is designed to target a decrease or elimination of appearance-related safety behaviors. individuals randomly assigned to the safety behavior fading condition will receive instructions to decrease or eliminate their endorsed appearance-related safety behaviors. in addition, they will receive daily reminders via text message to decrease these behaviors, along with a safety behavior monitoring checklist in which the participant indicates the extent to which they decreased and/or eliminated each safety behavior over the previous day. the daily reminder will include the following language: "hi! this is a friendly reminder to avoid using your checklist behaviors. please tap the link below to access today's checklist: \[link to checklist\]." text messages will be delivered using eztexting a text messaging platform used for research and marketing. note that no identifying information will be included in this platform. each participants phone number will be accompanied with a anonymized id code. individuals randomly assigned to the relaxing video condition will receive a total of 4 videos over the course of a month (1 video per week, 15 minutes each) wherein participants will be invited to close their eyes and focus their attention on the present moment while listening to relaxing piano music and songbirds.

Eligibility criteria:
inclusion criteria: * seeking treatment for appearance concerns exclusion criteria: * currently receiving treatment (therapy, counseling, etc.) for anxiety, depression, eating disorder, or body image/appearance concerns * if applicable, unstable psychiatric medication usage any time over the past 4 weeks

Keywords: appearance concerns safety behavior
to evaluate efficacy of ursodeoxycholic acid (udca) for the prevention of gallstone formation after gasterectomy

Conditions: Gastric Cancer

Summary: of those patients who participated in pegasus-d fas clinical trial, patient must sign the informed consent form in order to participate in this extension study. the medical records of the patients will be reviewed throughout the study.

of those patients who participated in pegasus-d fas clinical trial, patient must sign the informed consent form in order to participate in this extension study. * collection of retrospective cohort data 1)the medical records from the subject's gastrectomy surgery date to visit1 will be collected through a questionnaire and by reviewing the medical records of the patient. * collection of prospective cohort data 1. based on visit 1, if the subjects whose date of gastrectomy surgery date is more than 3 years(36 months) and less than 5 years(60 months), the subject should visit the institution at the time of 5 years(60 months, visit2) after gastrectomy surgery to evaluate data requested at visit2. 2. the medical records will be accessed and collected from the subject's gastrectomy surgery date up to 5 years(60 months)

Eligibility criteria:
inclusion criteria: among the pegasus-d full analysis set (fas) subjects, those who agree to participate in this clinical trial or those who can collect retrospective cohort data after waiving consent according to the consent waiver criteria exclusion criteria: a person who, at the discretion of the investigator, is deemed difficult to participate in this clinical trial.
media diversion in improving quality of life in patients with recurrent gynecologic cancers receiving chemotherapy

Conditions: Female Reproductive Cancer

Summary: this randomized clinical trial studies media diversion in improving quality of life in patients with recurrent gynecologic cancers receiving chemotherapy. media diversion may improve mood and quality of life in patients having cancer treatment.

primary objectives: i. to analyze the impact of a media-based intervention on patient mood during the receipt of chemotherapy for recurrent gynecologic cancers. outline: are randomized to 1 of 2 arms. arm i: participants are provided headphones and a tablet and choose among a selection of humorous movies. upon the third course of chemotherapy, participants are provided a selection of non-humorous movies. arm ii: participants are provided headphones and a tablet and choose among a selection of non-humorous movies. upon the third course of chemotherapy, participants are provided a selection of humorous movies.

Eligibility criteria:
inclusion criteria: * subjects with pathologically-proven gynecologic malignancies * subjects who have previously completed primary treatment for a gynecologic malignancy * patients receiving chemotherapy for a recurrent gynecologic cancer at the university of wisconsin-madison carbone cancer center (uwccc) * patients must be english speaking * patients must have the ability to use audio media and read and understand written english exclusion criteria: * patients unable to use audio or video media due to auditory or ocular dysfunction * patients unable to read written english * patients who are prisoners or incarcerated
i-scan with magnification for the detection of gastric intestinal metaplasia

Conditions: Gastric Intestinal Metaplasia

Summary: the purpose of this study is to assess whether i-scan with magnification can reduce the biopsy number needed per patient for the detection of gastric intestinal metaplasia without the loss of corresponding diagnostic yield.

gastric intestinal metaplasia is regarded as an important premalignant lesion for intestinal type gastric cancer. currently, the histological assessment of gastric intestinal metaplasia still relies on the biopsies took from five sites that the updated sydney system recommended. however, the updated sydney system biopsy protocol needs more biopsy number and procedure time, for it is unable to satisfy the diagnosis of gastric intestinal metaplasia. i-scan is a novel image-enhanced endoscopy system based on the post processing of reflected light without optical filters. targeted biopsy protocol based on i-scan with magnification will be possible for the diagnosis of gastric intestinal metaplasia. this study aims to compare the diagnostic yield of gastric intestinal metaplasia from i-scan with magnification targeted biopsies and a standard biopsy protocol and assess whether i-scan with magnification can reduce the biopsy number needed per patient for the detection of gastric intestinal metaplasia without the loss of corresponding diagnostic yield.

Eligibility criteria:
inclusion criteria: * patients with dyspeptic symptoms and aged 40 years or older * or patients with helicobacter pylori infection, or histologically verified gastric intestinal metaplasia or atrophic gastritis * or patients with family history of gastric cancer exclusion criteria: * presence of gastrectomy, acute gastrointestinal bleeding, or known gastric neoplasia * presence of conditions unsuitable for endoscopy procedure including coagulopathy, impaired cardiopulmonary function , pregnancy or breastfeeding * inability to provide informed consent
conventional endoscopic mucosal resection vs underwater resection for colorectal non-pedunculated colorectal lesions

Conditions: Adenoma; Colorectal Neoplasms

Summary: randomized, comparative and prospective study between conventional endoscopic mucosal resection for the removal of flat or sessile colorectal lesions without previous attempt to resection.

this prospective randomized trial was conducted in 2 academic services: instituto do câncer do estado de são paulo and centro de diagnóstico em gastroenterologia, both linked to the university of são paulo. the clinical study was performed in accordance to the declaration of helsinki.

Eligibility criteria:
inclusion criteria: * patients age \>18 years with sessile or flat colorectal lesions (measuring between 10 and 40mm), who consent to this study exclusion criteria: * patients who refuse to participate in the study. * patients with pedunculated, depressed or mixed lesions. * patients with lesions smaller than 10 mm or larger than 40 mm. * patients with lesions that are inflammatory, neuroendocrine or stromal at the pathology. * patients with lesions that were submitted to prior attempt to endoscopic resection.
a study to assess the safety, tolerability, effectiveness and absorption of exodif™ tablets in clostridium difficile-associated diarrhea

Conditions: Enterocolitis, Pseudomembranous; Diarrhea; Clostridium Difficile

Summary: approximately 65 patients will be entered into this study taking place in north america. the aim of this study is to evaluate the safety, efficacy and absorption of an investigational drug in patients with c. difficile-associated diarrhea (cdad). all study related care is provided including doctor visits, physical exams, laboratory tests and study medication. total length of participation is 6 weeks.


Eligibility criteria:
inclusion criteria: * the presence of cdad at the time of enrollment * negative serum pregnancy test (hcg) for women of childbearing potential. exclusion criteria: * any contraindication to oral / enteral therapy including fulminant c. difficile disease. * any acutely life-threatening medical conditions. * acute or chronic diarrhea of other cause.

Keywords: clostridium difficile disease infectious diarrhea c. difficile cdad clostridium difficile-associated diarrhea clostridium difficile diarrhea antibiotic-associated colitis clostridium enterocolitis antibiotic-associated diarrhea pseudomembranous colitis clostridium difficile
targeting processing speed deficits to improve social functioning and lower psychosis risk

Conditions: Psychosis; Prodromal Schizophrenia; Prodromal Symptoms

Summary: this 10 week intervention, specific cognitive remediation with surround (or scores), is designed to target processing speed, a cognitive domain related directly to social functioning, which in turn, represents a vulnerability factor for psychosis. this remotely-delivered intervention combining targeted cognitive training exercises and group support was developed to directly impact processing speed, and at the same time, boost motivation and engagement in adolescents at risk for schizophrenia and other psychotic disorders.

this study evaluates the effectiveness of a cognitive remediation (cr) program plus group coaching and support designed to improve processing speed and, in turn, social functioning and attenuated positive symptoms in individual considered clinical high risk for psychosis. the scores (specific cognitive remediation with support) intervention is a novel cognitive remediation program combined with group coaching, performance-based rewards, game-like tasks, and educational elements to increase engagement and retention. the study is funded by a r61/r33 award. in the r61 phase, all participants were asked to complete 40 hours of cognitive remediation or brain training (4 hours per week/10 weeks) with a mid-point assessment (at 5 weeks) to determine the training dose needed to impact processing speed as measured by the matrics cognitive consensus battery. the current r33 (phase 2) will look to replicate the results of the r61 and assess the specificity of the targeted intervention with the addition of a non-speeded cognitive training group..

Eligibility criteria:
inclusion criteria: * meet clinical high risk (chr) criteria on the structured interview for psychosis risk syndromes, defined by the presence of at least one attenuated positive symptom at a moderate to severe level * a score representing 0.5 sd below the mean on animal naming, trails a or bacs: symbol coding from the matrics consensus cognitive battery (mccb). exclusion criteria: * any dsm 5 schizophrenia-spectrum diagnosis * non-english speaking * past or current history of a clinically significant central nervous system disorder (e.g., seizure disorder) * estimated iq\<70 * significant head injury * significant substance abuse * significant visual or auditory impairment.

Keywords: clinical high risk (chr) processing speed social functioning social impairment social skills adolescents cognitive remediation
quantification and characterization of foot postoperative edema

Conditions: Surgery--Complications

Summary: in foot surgery, postoperative edema is a complication making the postoperative outcome quite uncertain as to the rehabilitation of the patient. the evolution of this edema is unknown ... the means of "mastering" this edema are empirical, with little study other than cryotherapy and restraint. this study aims to study postoperative edema in a cohort of patients undergoing forefoot surgery. the follow-up will be prospective with measurement of the volume of the foot using an optical technique, during the various follow-up consultations between day 8 and month 6 postoperative.


Eligibility criteria:
inclusion criteria: * major patient * patient operated on forefoot surgery * patient having given informed consent * for female patients of childbearing age, not to be pregnant or likely to be during the study, not to be breastfeeding exclusion criteria: * minor patient * patient deprived of his liberty or under guardianship * patient operated on for surgery of the forefoot other than hallux and lateral toes * patient unable to undergo protocol monitoring for psychological, social, family, geographic or linguistic reasons * patient with an underlying or concomitant pathology incompatible with inclusion in the trial, whether psychiatric or somatic * vulnerable people according to article l1121-6 of the csp
speech hero home therapy for aphasia

Conditions: Broca Aphasia

Summary: the investigators will run an at-home usability study of a newly developed speech therapy app called speech hero with 10 individuals with broca's aphasia in the chronic stage of stroke. the speech hero app allows users to perform rhythm-based speech exercises at home. for this study participants will be instructed to use speech hero for at least 10 hours over a 4-week period.


Eligibility criteria:
inclusion criteria: * diagnosis of broca's aphasia due to stroke, * \>6 months post stroke * sufficient motor function of the unaffected upper extremity to tap on a table while speaking exclusion criteria: * incidence of other neurological diseases (though individuals with apraxia will be included) * age \<85
mhealth + e-navigator stepped care on art adherence in latino msm

Conditions: ART Adherence

Summary: the goal of this study is to evaluate the efficacy of stepped care strategies to improve art adherence among adult latino msm with hiv using a sequential, multiple assignment, randomized trial (smart). the trial will compare a stepped care strategy of delivering txtxt ("treatment text") first and stepping up to remote patient navigation for non-responders vs. a stepped care strategy of delivering txtxt + e-navigation first and stepping up to ema-supported e-navigation for non-responders. both txtxt and the foundations of the e-navigation interventions are cdc evidence-based interventions (ebi). we propose to use a smart design which explicitly allows building, testing, and optimizing stepped care strategies without compromising rigor or randomization. we propose three specific aims: aim 1. compare the immediate (6-month) and sustained (9- and 12-month) efficacy of two static (non-stepped) treatment regimens (txtxt alone vs. txtxt + e-navigation) on art adherence and viral suppression among latino msm with hiv. hypothesis 1a. txtxt + e-navigation will be more efficacious than txtxt alone. aim 2. compare the immediate (6-month) and sustained (9- and 12-month) efficacy of two stepped care strategies (txtxt with added e-navigation for non-responders vs. txtxt + e-navigation with added ema support for non-responders) on art adherence and viral suppression among latino msm with hiv. hypothesis 2a: txtxt + e-navigation with added ema support for non-responders at the 3-month follow-up will be more efficacious than txtxt with added e-navigation for non-responders at the 3-month follow-up. aim 3. identify baseline and time-varying moderators on the association between stepped care strategy and art adherence and viral suppression among latino msm with hiv. hypotheses 3a-c: txtxt with added e-navigation for non-responders will be less efficacious than txtxt + e-navigation with added ema support for non-responders for individuals who are: (a) older at baseline, or report (b) substance use, or (c) symptoms of depression between baseline and the 3-month follow-up.


Eligibility criteria:
1. latino or hispanic 2. self-report male gender assigned at birth and identify as gay, bisexual, or previous sex with a man 3. age 18 or older 4. diagnosed with hiv and prescribed art least 1 month prior to study screening and enrollment 5. suboptimal adherence defined as (1) laboratory evidence of at least one detectable viral load in the past 12 months (≥20 copies/ml), (2) electronic medical record of at least one \<90% 30-day adherence period in the past 12 months, or (3) self-reported \<90% past 30-day adherence. 6. cell phone ownership and sms use: participants must own a personal cell phone for the intervention.

Keywords: hiv/aids treatment text ecological momentary assessment antiretroviral therapy adherence medication adherence viral suppression hiv care strategies latino hispanic men who have sex with men msm smart design
quality of life measures in patients with retinal degeneration

Conditions: Retinal Degeneration

Summary: inherited retinal degeneration (ird) is a major cause of blindness and partial loss of vision cases in the uk and starts at an early age. the purpose of this observational study is to use the results of two questionnaires and a computerised test testing contrast sensitivity, to assess the impact of ird on quality of life. this study will involve collecting data from patients with ird, but also collecting data from normal controls.

ird presents a significant burden on the nhs as well as on the individual and families. irds are particularly difficult in a family situation due to guilt and other complex emotions related to inheritance patterns. poorer mental health has been reported in patients with retinitis pigmentosa, manifesting in a range of ways including stress, depression and anxiety, particularly as the disease progresses. this is most probably caused by the uncertainty of the disease process and the progressive nature of the degeneration. recent work has reported that quality of life significantly deteriorates with a drop in visual field diameter of 20 degrees or a drop in visual acuity lower then logmar 0.3 (equivalent to 6/12). contrast sensitivity is often used in conjunction with va to assess visual capabilities. it is a measure of the ability to see reduced contrast and has a major impact on utility of vision. relating contrast sensitivity function to quality of life will provide valuable information about whether this aspect of vision is a critical measure for patient health. this is especially important as novel treatments are being developed for the treatment of irds.

Eligibility criteria:
inclusion criteria: * participant is willing \& able to give informed consent for participation in the study. * male or female, aged 18 - 85. * a clinical or genetic diagnosis of retinal degeneration or normal age and sex-matched controls without known retinal disease. * able to participate in visual function testing. exclusion criteria: * the participant may not enter the study if any of the following apply: * 1) they have a pre-existing amblyopia or squint; * 2) they have any other retinal problems that may confound the measures assessed.

Keywords: retina retinal degeneration quality of life measures
prevail-ta: placement of aortic balloon expandable transcatheter valves trial (europe)

Conditions: Aortic Valve Stenosis

Summary: a single arm, prospective multicenter non-randomized confirmatory clinical trial evaluating the edwards sapien xt™ transcatheter heart valve (model 9300tfx; "study valve"), the next generation ascendra™ transapical delivery system, and crimper accessories.

purpose: the purpose of this trial is to evaluate the acute safety and effectiveness of the sapien xt™ study valve and next generation ascendra™ delivery components. follow-up intervals: subject data collection will include clinical information at baseline and during the index procedure. subjects will undergo clinical follow-up at discharge, 30 days, 6 month annually for 5 years.

Eligibility criteria:
inclusion: 1. euroscore of ≥ 15 % 2. severe senile degenerative aortic valve stenosis 3. symptomatic aortic valve stenosis 4. informed consent 5. compliance exclusion: 1. logistic euroscore \> 40 % 2. evidence of an acute myocardial infarction 3. congenital unicuspid or congenital bicuspid valve/ non-calcified 4. mixed aortic valve disease

Keywords: sapien xt valve valvular heart disease aortic stenosis heart valve therapy transapical transcatheter