Kornimate/medical-research-clean huggingface dataset:
the evaluation of manual therapy for the prevention of radiation-induced fibrosis in patients with head and neck cancer

Conditions: Radiation-Induced Fibrosis in Patients With Head and Neck Cancer

Summary: the subjects in this study are the patients with head and neck cancer after completion of the radiotherapy. radiation-induced fibrosis is inevitable and there is no effective treatment to prevent it. therefore, there are two parts in this study : the first part is a pilot study. there will be 10 subjects included and manual therapy and rehabilitation will be arranged for 6 months. the manual therapy would be once a week at most, and the rehabilitation would be twice a week at most. the second part is a randomized controlled study. 60 patients would be randomized divided into two groups. the group 1 is manual therapy(once a week at most) and rehabilitation(twice a week at most), and the group 2 is rehabilitation only(twice a week at most). patients would be evaluated at baseline, 3rd, 6th, and 12th month. the evaluation is including the degree of superficial soft tissue fibrosis, numerical rating scale of pain, range of motion(neck), range of motion(shoulder), width of mouth opening, eortc qlq c30, eortc qlq h\&n 35, and functional oral intake scale. besides, swallowing video fluoroscopy would be done at baseline, 6th, and 12th month. when the subject completes the evaluation in the 12th month, the study is ended. because the radiation-induced fibrosis is progressed with time, we will follow up the condition of subjects at the next year and the following third year.


Eligibility criteria:
inclusion criteria : 1. age \> 20 years 2. head and neck cancer 3. after completion of radiation therapy for 4 to 6 weeks 4. be willing to accept manual therapy and long-term follow up exclusion criteria : 1. recurrence, metastatic cancer, or concurrent second cancer 2. with post-radiation dermatitis at neck or shoulder 3. current pregnancy or lactation 4. life expectancy of \< 12 months.

Keywords: head and neck cancer post-radiation fibrosis manual therapy rehabilitation
continuous pectoral nerve block in breast cancer surgery

Conditions: Nerve Blocks; Breast Surgery; Postoperative Pain

Summary: the purpose of the study is to evaluate the effect of continuous pectoral nerve block on postoperative analgesia consumption in breast cancer surgery.

pectoral nerve block has been developed as an alternative to thoracic paravertebral and/or thoracic epidural blocks in recent years. it is frequently applied for postoperative analgesia in breast cancer surgery.

Eligibility criteria:
inclusion criteria: * american society of anesthesiology (asa) i-ii * 18-65 years * body mass index (bmi) ≤40 kg/m2 * elective breast cancer surgery exclusion criteria: * asa ≥4 * under 18 years of age or over 65 years of age * declining to give written informed consent * history of allergy to the local anesthetics * contraendications of peripheral block or local anesthetic infiltration (local infection, coagulopathy, etc) * history of breast surgery * treatment due to psychiatric disorder * history of treatment for chronic pain * history of nerve blocks in order to treat postoperative pain

Keywords: pectoral nerve block (pecs block) breast cancer postoperative pain numeric rating scale score (nrs score)
comparing the effects of exercise on the structure and function of fat tissue

Conditions: Adiposity

Summary: assess differences in structure and biological function of abdominal subcutaneous adipose tissue samples collected from adults who exercise regularly vs. a well-matched cohort of non-exercisers.


Eligibility criteria:
inclusion criteria: * age: 18-40 years old * body mass index: 23-35 kg/m2 * women must have regularly occurring menses and must be premenopausal exclusion criteria: * evidence/history of cardiovascular or metabolic disease * medications known to affect lipid or glucose metabolism, or inflammation * weight instability ≥ ± 6 pounds in the last 6 months * tobacco or e-cigarette users * women must not be pregnant or actively lactating * blood pressure \> 140/90 mmhg
continuous negative external pressure for the treatment of primary snoring

Conditions: Snoring

Summary: the aim of this pilot study is to gain information on the ability of a continuous negative external pressure collar to safely reduce snoring in primary snorers, and if so to determine whether the reduction in snoring has benefits for both the snorer and the bed partner. this clinical trial will involve both the snorer and his or her bed partner, both of whom must qualify and provide informed consent for participation.


Eligibility criteria:
key snorer inclusion criteria: * bmi \<35 * if a previously done polysomnogram (psg) is available, ahi\<5 * snoring identified by a previous psg and/or by the bed partner key bed partner inclusion criteria * must have regularly slept with the snorer over the previous month and must plan to sleep with the snorer for the duration of the trial * considers that the snorer's snoring is a problem * must discontinue use of any snore-masking equipment or ear plug for at least two weeks prior to the initial visit to the study site and agree to refrain from their use for the duration of the trial key snorer exclusion criteria: * sleep disturbance other than snoring * snoring due primarily to abnormality of the nasopharynx * use of snoring treatment during the month prior to the initial visit * neck anatomic or skin abnormalities * serious medical condition * excessive drug or alcohol intake key bed partner exclusion criteria: -known sleep disorder

Keywords: primary snoring bed partner home sleep testing
safety and tolerability study of bms-986177 in healthy subjects

Conditions: Thrombosis

Summary: the purpose of this study is to determine the safety, tolerability, and pharmacokinetics of bms-986177 in healthy subjects


Eligibility criteria:
for more information regarding bms clinical trial participation, please visit www.bmsstudyconnect.com inclusion criteria: * healthy subjects as determined by no clinically significant deviation from normal in medical history, physical examination, ecgs and clinical laboratory determinations * body mass index (bmi) of 18 to 30 kg/m2 inclusive. bmi = weight (kg)/ \[height (m)\]2 * females who are not of childbearing potential (i.e., who are post-menopausal or surgically sterile) and men ages 18 to 55, inclusive exclusion criteria: * evidence of organ dysfunction or any clinically significant deviation from normal in physical examination, vital signs, ecg or clinical laboratory determinations beyond what is consistent with the target population * any condition that could affect drug absorption * other protocol-defined exclusion criteria could apply
effect of three fibres on glycaemic and insulinaemic responses in healthy adult volunteers

Conditions: Healthy Volunteers

Summary: the purpose of this study is to determine whether dupont experimental dietary fibre products 1 and 2 are digested using glycaemic and insulinaemic response as markers.

dupont experimental dietary fibre products 1 and 2 glycaemic and insulinaemic response will be compared against that of polydextrose and dextrose when given to adult healthy volunteers.

Eligibility criteria:
inclusion criteria: * bmi between 18-27 kg/m2. * self-diagnosed as healthy at the time of recruitment, confirmed by medical questionnaire: no reported current or previous metabolic diseases or chronic gastrointestinal disorders. * no blood donations during the study. * reported intense sporting activities \< 10hr/w. * reported alcohol consumption ≤21 units/w (female volunteers) or ≤28 units/w (male volunteers). * feasibility to give blood sample as per study protocol. * informed consent signed exclusion criteria: * dislike, allergy or intolerance to test products. * fasting blood glucose levels \ 6.1. * volunteer has any health conditions that would prevent him/her from fulfilling the study requirements, put the subject at risk or would confound the interpretation of the study results as judged by the principal investigator. * volunteer with history of diabetes and high blood pressure. * having consumed anything apart from plain water in the twelve hours prior to the first test day. * volunteer and/or immediate family member is an employee of the investigational site directly affiliated with this study, the sponsor or the clinical research organization. * reported lactating (or lactating \< 6 weeks ago), pregnant (or pregnant \< 3 months ago) or wish to become pregnant during the study. * reported participation in another biomedical trial 1 month before the start of the study.

Keywords: glycemic index dietary fiber
long-term safety study of intramuscular injections of 750 mg and 1000 mg testosterone undecanoate in hypogonadal men

Conditions: Hypogonadism; Primary Hypogonadism; Secondary Hypogonadism

Summary: to evaluate the pharmacokinetics of tu 750 mg and tu 1000 mg via multiple measurements of serum total testosterone.


Eligibility criteria:
inclusion criteria: * male with primary or secondary hypogonadism at least 18 years of age and for study part c2 weighs ≥143.3 lb (≥65 kg) * morning screening serum testosterone concentration \<300 ng/dl exclusion criteria: * american urological association (aua) symptom score ≥15 or significant prostatic symptoms * history of carcinoma, tumors or induration of the prostate or the male mammary gland including suspicion thereof * screening serum prostate-specific antigen (psa) level \>4 ng/ml or hyperplasia of the prostate (size \>75 cm3 as measured by transrectal ultrasonography) * past or present liver tumors or acute or chronic hepatic disease with impairment of liver function; liver function tests (alanine aminotransferase \[alt\], aspartate aminotransferase \[ast\]) exceeding 1.5 times upper limit of normal * history of deep vein thrombosis in the past 5 years or any history of cerebrovascular accident * severe acne * hypertension (systolic blood pressure \>160 mm hg and diastolic blood pressure \>95 mm hg) or coronary heart disease not stabilized by therapy as assessed by the investigator * insulin-dependent diabetes mellitus or uncontrolled non-insulin-dependent diabetes mellitus; patients with diabetes are excluded if screening glycated hemoglobin (hba1c) level is \>9% * use of any sex hormones within 28 days (for injectable testosterone preparations) or 7 days (for oral, gel, patch, etc, testosterone preparations) prior to screening visit and throughout the study (exclusive of administered study drug) * use of steroidal anabolic drugs or supplements (eg, dehydroepiandrosterone \[dhea\]) by any application method within the 28 days prior to first administration of study drug and throughout the study (exclusive of administrated study drug) * medication with substances which might interfere with testosterone metabolism within 28 days before the first administration of study drug * history of sleep apnea insulin-dependent diabetes mellitus * use of steroidal anabolic drugs or supplements by any application method within the 28-days prior to the first administration of the study drug and throughout the study (exclusive of the administered study drug)

Keywords: investigational testosterone testosterone undecanoate tu hypogonadism primary hypogonadism secondary hypogonadism
safety and efficacy of daclatasvir (bms-790052) plus standard of care (pegylated-interferon alpha and ribavirin)

Conditions: Hepatitis C Infection

Summary: the purpose of this study is to identify 1 or more doses of daclatasvir, which when used in combination with pegylated interferon alpha and ribavirin, are safe and demonstrate sufficient anti-hepatitis c virus activity.


Eligibility criteria:
key inclusion criteria: * patients chronically infected with hepatitis c virus (hcv) genotype 1 * hcv rna viral load of ≥10\*5\* iu/ml (100,000 iu/ml) at screening * treatment naive key exclusion criteria: * women of child-bearing potential * cirrhosis * coinfection with hiv or hepatitis b virus

Keywords: antivirals
da vinci sp robotic gastrectomy

Conditions: Gastric Cancer

Summary: laparoscopic surgery revolutionized the surgical treatment of gastric cancer saving large incsion and associated pain. robotic surgical system was introduced to enhance the minimally invasive surgery using articulating robotic arm. the da vinci sp system, which enables single-port surgery, can allow surgeon to provide radical gastrectomy with minimal scar and associated pain.

this study is a phase 1/2, single-arm surgical clinical trial. the primary endpoint is the safety of da vinci robotic gastrectomy. the secondary endpoint is operative time, bleeding, bowel recovery, and hospital stay. in the clinic, informed consent is received from patient who is scheduled to undergo radical gastrectomy. after the general anesthesia, low midline transverse incision is made at suprapubic area. after inserting sp port into the peritoneal cavity, additional port is inserted via right flank that would be used for assistant's energy device and suction devices. radical subtotal gastrectomy is perfromed using cardiere-forceps, monopolar scissors, and maryland forceps. reconstruction after gastrectomy is decided according to surgeon's preference. three days after gastrectomy, if the diet build up is complete and the patients has no evidence of complication, the patient is discharged from the hospital. four weeks after gastrectomy, the patient will be followed up at the clinic. major complication event within 30days after gastrectomy will be analyzed as primary endpoint as well as other secondary endpoints.

Eligibility criteria:
inclusion criteria: * biopsy confirmed adenocarcinoma of stomach scheduled to undergo radical gastrectomy * between 20-80 * asa score (american society of anesthesiology) class: i - iii * signed to informed consent after through explanation about the study exclusion criteria: * distant metastasis * emr/esd canddiate * complicated gastric cancer (obstruction or perforation) * active other primary tumor * vulerable subject (illiterate, pregnant)

Keywords: da vinci sp robotic surgery gastrectomy gastric cancer
the relationship between education status and care burden of mothers of individuals with cerebral palsy

Conditions: Cerebral Palsy

Summary: this study, examines how maternal education affects caregiving burdens for children with cerebral palsy. cerebral palsy requires long-term, intensive care, often leading to significant physical, emotional, and financial strain on caregivers. the study aims to assess whether higher maternal education is associated with lower care burdens, possibly due to increased access to resources or coping strategies, and whether lower educational levels result in greater challenges. a survey, combined with standardized measures such as the caregiver burden scale, will be used to quantify the caregiving burden. the results are expected to inform policies or interventions aimed at reducing caregiver strain.

this study titled "the relationship between the education status of mothers and the care burden of individuals with cerebral palsy" aims to explore how the education level of mothers influences their caregiving responsibilities and burdens while caring for individuals with cerebral palsy. cerebral palsy, a neurological disorder affecting movement and muscle tone, often requires lifelong caregiving, which can be physically, emotionally, and financially demanding. the study seeks to investigate whether mothers with higher levels of education experience lower care burdens due to greater access to resources, knowledge of coping strategies, or better healthcare utilization. conversely, the study will also examine if mothers with lower educational attainment face more significant challenges due to limited access to support systems or information. the research will involve a mixed-methods approach, including a survey to assess the education level of mothers and the care burden they experience. specific tools to measure care burden, such as the caregiver burden scale, will be employed. the findings aim to provide insights into the role of education in mitigating caregiving challenges and inform potential interventions or policies that could support caregivers in these situations.

Eligibility criteria:
inclusion criteria: * having a child who is receiving education in special education institutions * the child's diagnosis was made at least 6 months ago * the disabled individuals must be between the ages of 0-18 exclusion criteria: -

Keywords: cerebral palsy caregiver burden mother educational status
prevalence of asymptomatic thrombosis in multiple myeloma

Conditions: Thrombosis; Multiple Myeloma

Summary: malignant hemopathies, such as solid cancers, increase the risk of venous and arterial thromboembolic events. the incidence of symptomatic venous thromboembolic events is particularly high in myeloma, linked to the usual risk factors for venous thromboembolic disease, biological risk factors specific to myeloma, and especially to its treatments. the prevalence of asymptomatic venous thromboembolic events and arterial events are not known to date and remain important data for planning a possible randomized study to determine the most suitable thromboprophylaxis in these patients.


Eligibility criteria:
inclusion criteria: * patient major age ≥18 years * patients with symptomatic myeloma meeting the definition of the international myeloma working group, regardless of the therapeutic line, including patients in remission and untreated. * patient having given informed consent, signed. * patient benefiting from a social security scheme exclusion criteria: * patients with non-symptomatic myeloma (stage i) or gammapathy of unknown significance (mgus). * patient undergoing antithrombotic treatment for deep or superficial venous thrombosis and / or pulmonary embolism at the time of inclusion. * patients with occlusive arterial disease of the lower limbs known at the time of inclusion. * minors, protected adults and patients deprived of liberty or not affiliated to a social security scheme * pregnant woman * patient unable to express consent. * patient under guardianship or curatorship or patient deprived of public liberty
protocol to permit the acquisition of circulating tumor material in pancreatic diseases

Conditions: Pancreatic Diseases

Summary: the purpose of this study is to collect blood samples to detect potential markers of pancreatic cancer in the blood and link these findings to medical and health information. information from this study may help to provide insight into the detection of pancreas cancer in the blood before it can be found by other methods or provide a method of monitoring the status of pancreatic cancer throughout a treatment course. another purpose of this study is to collect blood to create a biobank.


Eligibility criteria:
inclusion criteria: 1. the subject must be a patient at the hospital of the university of pennsylvania * the subject must be under evaluation and/or treatment for a pancreatic disease * the subject must be under evaluation and/or treatment for a non-pancreatic disease. for example, patients undergoing routine colonoscopy within the clinical practice will be asked to consent to provide control samples. 2. the subject must be able to provide informed consent or have an acceptable surrogate capable of giving consent on the subject's behalf 3. the subject must be 18 years of age or older exclusion criteria: 1. the subject or acceptable surrogate does not provide informed consent 2. subject is a prisoner 3. subject is under 18 years of age
continuous glucose monitoring for personal protective equipment evaluation

Conditions: Diabetes Mellitus (DM)

Summary: diabetes mellitus (dm) affects roughly 8% of pregnancies and is associated with significant perinatal and maternal morbidity. current obstetric practice is complicated by the emergence of the sars-cov-2 pandemic, resulting in morbidity and mortality secondary to complications of covid-19. care coordination among the teams caring for women admitted for antepartum, intrapartum, and postpartum care with suspected or confirmed covid-19 is required to conserve ppe and minimize staff exposure. the investigators propose a pilot proof of concept randomized study to evaluate the utility of dexcom-g6 continuous glucose monitors for assessment of glycemic control in pregnant and postpartum women with insulin-requiring diabetes mellitus during hospitalizations, as a proof of concept in the efforts to reduce the number of point of care glucose tests needed, reduce staff exposure, and conserve ppe use.


Eligibility criteria:
inclusion criteria: * women aged 18-50 years with a viable singleton or twin intrauterine pregnancy between 8 0/7 and 41 6/7 weeks gestation based on the best obstetric estimate by acog criteria * diagnosis of pre-gestational or gestational diabetes mellitus a2, admitted to the hospital for labor or other antepartum admissions (besides dka or glucoregulation) * able to understand the study, and having understood, provide written informed consent in english * infants who survive to hospital discharge who are born to women enrolled in the study exclusion criteria: * participation in another trial that may influence the primary outcome, without prior approval * higher order pregnancy * history of severe skin allergy to adhesive products or cgm * dka, admission for glucoregulation * covid-19 pui or confirmed positive
effect of extracorporeal shock wave in the treatment of knee osteoarthritis

Conditions: Knee Osteoarthritis; Cartilage Injury

Summary: in this study, the effectiveness of eswt in the treatment of knee oa was investigated from the perspective of cartilage injury，and to prove that shockwave could delay the early and middle stage oa progression by improving cartilage condition


Eligibility criteria:
inclusion criteria: * knee joint rom normal or near normal: flexion 110 ° or reach 0 ° or less * mr prompt exist cartilage damage, there is no lack of full-thickness cartilage * kellgren - lawrence (k - l) grade ii - iii grade * the international association of cartilage repair cartilage damage grading system (icrs) class i - iii * informed consent and sign relevant documents * follow doctor's instructions and follow up on time exclusion criteria: * metabolic arthritis * trauma of bone joint * inflammatory diseases * previous knee surgery history * history of knee cavity injection in the past 6 months * serious cardiovascular diseases, pulmonary diseases or other serious diseases affecting survival, etc

Keywords: extracorporeal shock wave therapy knee osteoarthritis cartilage injury