Kornimate/medical-research-clean huggingface dataset:
epidemiologic study of hepatocellular carcinoma in the us

Conditions: Hepatocellular Carcinoma

Summary: the purpose of this study is: * to investigate the risk factors of hcc among americans with focus on lifestyle factors and energy balance. * to identify single nucleotide polymorphisms (snps) and haplotypes that are associated with hcc risk through a genome-wide search. * to assess if genetic susceptibility differs by hepatitis virus infection or lifestyle factors, and to explore if there are interplays or effect modifications between genetic factors and viral infection or lifestyle factors.


Eligibility criteria:
inclusion criteria for hcc cases: * a diagnosis of primary liver cancer (excluding secondary tumors) * a diagnosis of hepatocellular carcinoma if histology is available (excluding those diagnosed in intrahepatic bile duct, bile canals, biliary passages, canaliculi, gall duct and gallbladder) * a diagnosis of hepatocellular carcinoma with or without microscopic evaluation (including those diagnosed with clinical evidence, lab tests and direct visualization or radiographic and other imaging evidence) * a histology of primary hepatocellular carcinoma when the patients had a prior diagnosis of other forms of cancer (excluding those who had no histological diagnosis of hepatocellular carcinoma while having a prior history of other cancer; * age at diagnosis between 35 and 84 years * living in connecticut, new jersey, new york, or hawaii for at least a year as regular residents. exclusion criteria for hcc cases: * uncertain diagnoses or classification of malignancy, such as unknown origin * a diagnosis of primary tumors in other organs, not in the liver * unable to communicate well enough in english or spanish * having medical conditions, such as mental disorders, that prevent the subject from providing reasonably comprehensible information or from being able to give informed consent. * diagnosed at age \ 84 years * temporary residents of new jersey, connecticut, new york, or hawaii inclusion criteria for control subjects: * age between 35 and 84 years * living in new jersey or connecticut for at least a year as regular residents * able to communicate well in english or spanish * having no medical conditions, such as mental disorders, that prevent them from providing adequately comprehensible information * potential subjects with a previous history of cancer are eligible. exclusion criteria for control subjects: * age \ 84 years * temporary residents of new jersey or connecticut * unable to speak english or spanish * cannot provide adequately comprehensible information

Keywords: hepatocellular carcinoma
assessment of the concentrations of besifloxacin, moxifloxacin, or gatifloxacin in the aqueous humor of subjects

Conditions: Cataract Extraction

Summary: this study is being conducted to assess the concentration of besifloxacin, moxifloxacin, or gatifloxacin in aqueous humor samples collected following topical instillation of the associated formulation in subjects undergoing cataract surgery.


Eligibility criteria:
inclusion criteria: * subjects who are a candidate for a routine, uncomplicated, primary cataract extraction. * subjects who, in the investigator's opinion, have potential for postoperative best corrected snellen visual acuity of at least 20/200 in the study eye. exclusion criteria: * subjects who have a known sensitivity, contraindication, or allergy to the study medication(s) or their components. * subjects who had any corneal refractive surgery in the study eye. * subjects who have a history or presence of chronic generalized systemic disease that the investigator feels might increase the risk to the subject or confound the result of the study. * subjects who had ocular surgery in the study eye, including laser procedures, within the past 6 months. * subjects who have taken any topical ocular medication in the study eye, other than those required by the protocol and permitted for surgery, during the 24 hours prior to the study medication being instilled. * subjects who use any antibiotics (e.g., systemic or topical) within the 7 days prior to the surgery date. * subjects who are monocular.

Keywords: bioavailability
spect fibroblast activation protein imaging in patients with cardiac disease

Conditions: Myocardial Fibrosis

Summary: this observational study aims to learn about the preliminary exploration of 99mtc-fapi imaging in heart diseases and its potential application. participant involves patients with myocarditis, pulmonary hypertension, arrhythmia, myocardial infarction, dilated cardiomyopathy, and cardiac tumors, health conditions may also studied as control. the main questions it aims to answer are 1, radionuclide 99mtc labeled fibroblast-activated protein inhibitors (99mtc-fapi) imaging in the use of cardiac diseases and its limitations. 2, the performance in subjects with different control of hypertension to evaluate myocardial injury and fibrosis for providing a molecular biological basis for the study of diseases and mechanisms. participants will undergo 99mtc-fapi imaging by single-photon emission computed tomography (spect) and record their cardiac disease characterization and treatment.


Eligibility criteria:
inclusion criteria: * clinical diagnosis or suspected of cardiac injury * must be able to receive pet/ct scan exclusion criteria: * pregnant women * severe claustrophobia
effect of mops during orthodontic movement in periodontitis patients

Conditions: Stage IV Periodontitis; Orthodontic Tooth Movement

Summary: micro-osteoperforations (mops) cause cortical bone injuries and consequently increase the expression of inflammatory mediators, allowing for increased bone and periodontal ligament remodeling associated with orthodontic movement. it remains unclear the effect of orthodontic intrusion combined with mops application on teeth with reduced periodontium. the general objective will be to determine the efficacy of mops during orthodontic tooth movement (otm) in terms of periodontal and orthodontic outcomes in stage iv periodontitis patients, case type 2 with pathological tooth migration (ptm), characterized the presence of at least one flared tooth of the upper-anterior sextant with an intrabony defect (intrabony component \<5mm)

this is a comparative 2-arm parallel single-blinded randomized controlled clinical trial, with allocation ratio of 1:1, aimed to test an intervention (the use of mops) on cal changes 12 months after placing orthodontic appliances. the control intervention will be the same treatment without the bone traumatic intervention. sample: patients with stage iv periodontitis case type 2 characterized with ptm characterized the presence of at least one flared tooth of the upper-anterior sextant with an intrabony defect (intrabony component \<5mm) attending the post-graduate program of periodontology and the post-graduate program of orthodontics of the faculty of dentistry at the complutense university of madrid (ucm).

Eligibility criteria:
inclusion criteria: patients will be included if agreeing to undertake combined periodontal and orthodontic therapy following the clinical practice guideline of stage iv periodontitis patients, and fulfilling the following criteria: * adult patients older than 18-year-old; * systemically healthy (see exclusion criteria); * diagnosed as stage iv (papapanou et al., 2018) case-type 2 (herrera et al. 2022) periodontitis; * the presence of at least one flared tooth of the upper-anterior sextant with an intrabony defect (intrabonny component \<5mm) (experimental teeth); * in need of orthodontic therapy. exclusion criteria: * systemic diseases (diabetes mellitus, obesity, cardiovascular diseases); * any medication that could affect the level of inflammation, (such as chronic antibiotics, phenytoin, cyclosporin, anti-inflammatory drugs, systemic corticosteroids, or calcium channel blockers); * pregnant or lactating woman; * inability to respond questions or to attend follow-up visits; * extreme skeletal malocclusions requiring orthognathic surgery; * patients smoking more than 10 cigarettes/day; and * the presence of pd greater or equal to 5mm with bop after step 3 of periodontal therapy

Keywords: stage iv periodontitis orthodontic tooth movement micro-osteoperforations
evaluation of the effectiveness of a regional trauma care system for the treatment of patients with severe trauma

Conditions: Trauma

Summary: severe trauma imposes a heavy burden to society and family because of its high mortality and disability rate. based on the implementation plan of "one region", "two links", and "three teams", the trauma medicine center of peking university people's hospital has constructed regional trauma care system that is suitable for china's national conditions. the primary objective of this trial is to evaluate the effectiveness of the regional trauma care system on the treatment of patients with severe trauma in china.this study is a prospective, multicenter, stepped-wedge cluster-randomized controlled clinical trial.

background: severe trauma imposes a heavy burden to society and family because of its high mortality and disability rate. based on the implementation plan of "one region", "two links", and "three teams", the trauma medicine center of peking university people's hospital has constructed regional trauma care system that is suitable for china's national conditions. the primary objective of this trial is to evaluate the effectiveness of the regional trauma care system on the treatment of patients with severe trauma in china. methods: this study is a prospective, multicenter, stepped-wedge cluster-randomized controlled clinical trial. twenty hospitals are selected based on specific eligibility criteria. after the baseline period, 5 randomization steps with 4 hospitals per step will be conducted. each hospital will gradually enter intervention period in the randomized order for the implementation of regional trauma care system. the initial 1-month is considered as the intervention transition period, during which hospitals are modified and healthcare workers are trained according to the requirements of the regional trauma care system. conclusion: this is the first study assessing the effectiveness of the regional trauma care system on the treatment of patients with severe trauma with the conduction a prospective study in china.

Eligibility criteria:
inclusion criteria: 1. age of 18-60 years old, with no restriction on gender; 2. severe trauma, including trauma patients with iss score ≥ 16; 3. time from trauma to admission \<24h. exclusion criteria: 1. patients who complicated with underlying diseases, such as malignant tumor and diabetes mellitus; 2. patients with important organ dysfunction before trauma; 3. the investigator considers not appropriate for enrollment. -
cftr modulators in pregnancy and postpartum

Conditions: Cystic Fibrosis

Summary: observational study on women with cystic fibrosis treated with cftr modulators during pregnancy and postpartum and their children. registration on maternal health parameters and effects of cftr-modulators in the newborn infant as well as effects of exposure through mother's own milk.


Eligibility criteria:
inclusion criteria: woman with cystic fibrosis who is pregnant and treated with kaftrio. newborn infant to the above mentioned woman exclusion criteria: none
isolated pancreatic loop with modified pancreaticojejunostomy

Conditions: Pancreaticoduodenectomy

Summary: the aim of the present study was to observe whether the modified pancreatico- jejunostomy (pj ) technique with an isolated pancreatic loop would effectively reduce the popf rate and overall morbidity after pd

postoperative pancreatic fistula (popf) is widely regarded as the most threatening complication following pancreaticoduodenectomy (pd). its clinical impact and sequelae have been previously described and shown to contribute to the development of other morbid complications and high rates of mortality. the aim of the present study was to observe whether the modified pancreatico- jejunostomy (pj ) technique with an isolated pancreatic loop would effectively reduce the popf rate and overall morbidity after pd. methods: we report our early experience using a modified pj technique with an isolated pancreatic loop after after pd in 201 patients between january 2010 and december 2020.

Eligibility criteria:
inclusion criteria: * age up to 30 * head of the pancreas tumor exclusion criteria: * body and tail pancreatic tumors

Keywords: pancreaticoduodenectomy pancreaticojejunostomy postoperative pancreatic fistula.
cardiopulmonary response to conical-pep breathing during exercise in older people.

Conditions: Aging

Summary: aim of this study is to compare cardiopulmonary response to conical-pep breathing during exercise in older people.

it is known that all most structures and physiological functions deteriorate with age, leading to decrease exercise performance, functional decline and gradual decrease of physical activity in aging. the most essential change of respiratory physiology are: dilatation of alveoli, enlargement of air space, decrease gas exchange surface area, loss of supporting tissue for distal airway (senile emphysema), decrees of chest wall compliance and decrease of respiratory muscle strength. these changes leading to decrease lung elastic recoil, increase residual volume and functional capacity, and increase work of breathing at rest. in addition, such changes affect respiratory function, especially dynamic hyperinflation (dh) development which could be one of the factors relate to dyspnea during exercise in aging positive expiratory pressure (pep) therapy for dh treatment during exercise was reported in several studies. it is possible that pep breathing may improve cardiopulmonary response to exercise in older people.

Eligibility criteria:
inclusion criteria: * elder age between 60 to 80 years old with normal spirometry exclusion criteria: * they are diagnose with cardiovascular disease and, i.e. valvular heart disease, coronary heart disease, congenital heart disease, myocardial heart disease, uncontrolled hypertension, hyperlipidemia; or, present abnormal sign of heart problems previous month, such as chest pain, arrhythmia, abnormal ecg. * they are impair balance from neuromuscular, musculoskeletal, or vestibular problem affecting cycling and walking.

Keywords: positive expiratory pressure cardiopulmonary responses exercise older people
research on the effect of noise cancelling headphones in reducing postoperative pain

Conditions: Noise Cancelling Headphones; Postoperative Pain

Summary: this randomized controlled trial selects patients undergoing gynecological laparoscopy under general anesthesia. by using noise reduction earphones during surgery, the patient's postoperative pain score and demand for opioids are observed, providing a basis and reference for the efficacy and safety of noise reduction earphones in gynecological endoscopic surgery.

every year, 200 million surgical procedures are performed worldwide, and 40-65% of patients experience moderate to severe pain after surgery failure to provide sufficient postoperative analgesia increases the risk of surgical complications and affects patients' early activity and recovery . opioids are still the main method of treatment, and their side effects include urinary retention, itching, nausea, vomiting, postoperative intestinal obstruction, dizziness and cognitive impairment . researchers pay more and more attention to non pharmacology and non-invasive analgesia methods, including music therapy, traditional chinese medicine acupuncture and moxibustion and watching educational videos . due to the introduction of various surgical tools, the noise pollution in the operating room has gradually intensified, affecting surgical patients and medical staff. previous studies have shown that general anesthesia does not hinder the brain's processing ability for sound and language; the patient's auditory cortex remains active , and even in anesthesia induced coma, the patient can still maintain the ability to understand auditory information. other recent studies have found that intraoperative exposure to positive auditory stimuli, including music, treatment suggestions and white noise, can reduce postoperative pain, environmental protection, and acupuncture and moxibustion can also have a similar positive impact . therefore, this randomized controlled trial selects patients undergoing gynecological laparoscopy under general anesthesia. by using noise reduction earphones during surgery, the patient's postoperative pain score and demand for opioids are observed, providing a basis and reference for the efficacy and safety of noise reduction earphones in gynecological endoscopic surgery.

Eligibility criteria:
inclusion criteria: asa grade i or ii, aged 18-55 years , female were selected for gynecological laparoscopy under elective general anesthesia. - exclusion criteria: history of serious illness requiring further care in the intensive care unit after surgery; abnormal hearing; postoperative mechanical ventilation or continued anesthesia or sedation is required; preoperative chronic pain or long-term use of painkillers; other factors that hinder patients from cooperating with the research plan -
randomized, controlled, single-blind exploratory study of the efficacy and safety of wrist and ankle acupuncture intervention on nausea, vomiting and pain after sleeve gastric surgery in women

Conditions: Laparoscopic Sleeve Gastrectomy; Postoperative Nausea and Vomiting

Summary: ponv is the most common clinical presentation after surgical procedures beyond pain. a retrospective study of our center found that the postoperative incidence of lsg was 77.4%. ponv can not only cause postoperative discomfort, but also cause serious complications such as disturbance water and electrolyte balance, wound splitting, incisional hernia, and even residual gastric leakage and aspiration pneumonia, resulting in prolonged hospital stay and increased medical costs. wrist and ankle acupuncture is a special kind of acupuncture therapy. through subcutaneous stimulation, the electrical signal is fed back along the nerve fiber into the cerebral cortex, without dialectical treatment, and only needs the appropriate symptoms and signs of the patient. although only in the wrist and ankle, it can solve a series of problems in the whole body, especially nausea, vomiting and pain symptoms.

patients scheduled for female sleeve gastric surgery were selected, and the trial was designed into the control group (n=33) and the intervention group (33). the intervention group was based on the control group, combined with the intervention of the wrist and ankle acupuncture, namely, the wrist and ankle acupuncture treatment was started 1 day before the surgery. take up and down 1,2 area as a needle point, use hua tuo brand sterile acupuncture needle (specification: 0.25mm 25mm), into the skin disinfection into the needle, keep 30 subcutaneous needle and skin, when the operator under the needle, patients without acid swelling, pain, close to the skin dermis, to about 1.5 inches, give tape fixed 24h, left under the skin, until postoperative 3 day.

Eligibility criteria:
inclusion criteria: * in accordance with the guidelines for surgical treatment of obesity and type 2 diabetes in china (2019 edition); * asa grades ii-iii; age: 18-65 years old; * denial of smoking history; * denied any history of motion sickness or ponv; * female patients proposed to undergo laparoscopic sleeve gastrectomy under elective general anesthesia; * voluntary attended and signed informed consent. exclusion criteria: * with known drug allergies related to this study; * severe heart, respiratory, renal or liver diseases, and coagulation disorders; * psychiatric or neurological disorders; * difficulties in communication; * premedication or premedical conditions limits target assessment, including use of antiemetics, opioids or corticosteroids (excluding anesthetic medication); * gastroesophageal reflux (gred), clinically assessed as severe gred or preoperative gastroscopy indicating grade b of oesophagitis or above; * patients undergoing combined cholecystectomy and gynecological surgery during the operation.
observational study of metalyse® in patients with acute myocardial infarction in russian federation

Conditions: Myocardial Infarction

Summary: primary: to support the regulatory approval process of metalyse® in russian federation. secondary: to assess the efficacy and safety of single bolus of metalyse® tnk-tissue plasminogen activator (tnk-tpa, tenecteplase ) in patients with acute myocardial infarction in usual routine treatment after market launch


Eligibility criteria:
inclusion criteria: * onset of symptoms of ami within 6 hours * on a twelve-lead electrocardiogram (ecg), st-segment elevation ≥ 0.1 millivolt (mv) in two or more limb leads, or \> 0.2 mv in two or more contiguous precordial leads indicative of ami, or left bundle-branch block * age ≥ 18 exclusion criteria: * significant bleeding disorder at present or within the past 6 months, known hemorrhagic diathesis * patients with current concomitant oral anticoagulant therapy with international normalised ratio (inr) \> 1.3 * any history of central nervous system damage (i.e. neoplasm, aneurysm, intracranial or spinal surgery) * severe uncontrolled arterial hypertension (hypertension defined as blood pressure 180/110 mm hg (systolic bp \> 180 mm hg and/or diastolic bp \> 100 mm hg) on one single reliable measurement during current admission prior to study enrolment * major surgery, biopsy of a parenchymal organ, or significant trauma within the past 2 months (this includes any trauma associated with the current ami), recent trauma to the head or cranium * prolonged or traumatic cardiopulmonary resuscitation (\> 2 minutes) within the past 2 weeks * severe hepatic dysfunction, including hepatic failure, cirrhosis, portal hypertension (esophageal varices) and active hepatitis * diabetic hemorrhagic retinopathy or other hemorrhagic ophthalmic conditions * active peptic ulceration * arterial aneurysm and known arterial/venous malformation * neoplasm with increased bleeding risk * acute pericarditis and/or subacute bacterial endocarditis * acute pancreatitis * hypersensitivity to the active substance tenecteplase and to any of the excipients * use of abciximab (reopro®) or other marketed gpiib/iiia antagonists within the preceding 12 hours * any minor head trauma and any other trauma occurring after onset of the current myocardial infarction * any known history of stroke or transient ischemic attack or dementia * pregnancy or lactation, parturition within the previous 30 days. women of childbearing potential must have a negative pregnancy test * any known active participation in another investigative drug study or device protocol in the past 30 days * previous enrollment in this study * inability to follow protocol and comply with follow-up requirements * any other condition that the investigator feels would place the patient at increased risk if the investigational therapy is initiated