Kornimate/medical-research-clean huggingface dataset:
hpv self-sampling for underscreened latinas

Conditions: Uterine Cervical Neoplasm

Summary: the goal of this study is to learn if women of hispanic/latina ethnicity are willing to self-collect a cervico-vaginal sample for hpv testing. the main question the study will answer is: • does a brief educational intervention increase the feasibility and acceptability of hpv self-sampling among hispanic/latina women? the study team will compare whether including a brief educational intervention with a mailed hpv self-sampling kit is more acceptable than receiving a mailed hpv self-sampling kit alone. participants will be asked to complete surveys at study entry (baseline) and then randomized to receive only the hpv self-sampling kit, or the kit plus a small group education that meets with a bilingual health educator. participants will then be contacted about one-month later to complete a follow-up survey. the study team will also measure the number of participants in each group who self-collect a sample and mail it in for hpv testing.

the study team will recruit a sample of underscreened latinas (n=100) who will be randomly assigned to either the educational intervention (n=50) or a control condition (n=50). feasibility will be measured through study enrollment and intervention completion (defined as the proportion of women who self-collect a sample). acceptability of intervention materials and self-sampling procedures will be measured using self-report surveys at follow-up assessments.

Eligibility criteria:
inclusion criteria: * self-reported hispanic/latina ethnicity * assigned female sex at birth * age 30-65, consistent with guidelines for hpv dna testing for cervical cancer screening * speak and read english or spanish * computer or other device with internet connection * overdue for cervical cancer screening (e.g., no cytology-based screening within the past 3 years; no hrhpv testing either alone or in combination with cytology in the past 5 years). exclusion criteria: * prior diagnosis of cervical cancer or abnormality (e.g., dysplasia) * had a hysterectomy/removal of the cervix * compromised immune system (e.g., known hiv) * women who self-report that they are pregnant or are within three months after a pregnancy
the skin savvy study: a behavioral skin cancer prevention intervention

Conditions: Skin Cancer Prevention

Summary: the purpose of the proposed project is to investigate the efficacy and longevity of two novel approaches to changing skin protection behaviors: 1) uv-detect photos that reveal currently existing skin damage and 2) motivational interviewing (mi), a person-centered, yet directive counseling style used to enhance internal motivation to change health behaviors. the proposed investigations include a pilot study to refine the methodology; a small formal randomized controlled efficacy trial; and a dismantling study. these studies will also expand current knowledge and research in several major ways: 1) the use of uv-detect photos will enable highly salient and personalized feedback, 2) mi will be used in a previously untried health domain (skin cancer prevention), 3) objective skin color changes will be measured using state-of-the-art skin reflectance spectrophotometry, and 4) the proposed studies will test aspects of several major psychological theories (e.g., transtheoretical model, prototype/willingness model) to identify moderators/mediators of outcome.

teens and young adults are at high risk for overexposure to ultraviolet (uv) radiation, a leading factor in the development of skin cancer. the majority of these individuals continue to protect themselves minimally and tan intentionally, including significant increases in tanning booth use recently. such care-free behaviors exist despite widespread education/awareness about uv radiation and skin cancer. the purpose of the proposed project is to investigate the efficacy and longevity of two novel approaches to changing skin protection behaviors: 1) uv-detect photos that reveal currently existing skin damage and 2) motivational interviewing (mi), a person-centered, yet directive counseling style used to enhance internal motivation to change health behaviors. the proposed investigations include a pilot study to refine the methodology; a small formal randomized controlled efficacy trial; and a dismantling study. these studies will also expand current knowledge and research in several major ways: 1) the use of uv-detect photos will enable highly salient and personalized feedback, 2) mi will be used in a previously untried health domain (skin cancer prevention), 3) objective skin color changes will be measured using state-of-the-art skin reflectance spectrophotometry, and 4) the proposed studies will test aspects of several major psychological theories (e.g., transtheoretical model, prototype/willingness model) to identify moderators/mediators of outcome. therefore, the studies should provide useful information about process and outcome for skin cancer prevention researchers and clinicians.

Eligibility criteria:
inclusion criteria: * 18 or older exclusion criteria: * visual impairment
ultrasound guided costotransverse block for breast cancer surgery

Conditions: Postoperative Pain

Summary: costotransverse block is a novel regional anesthesia technique described a few months ago. it's use for breast surgery has been reported by only one case report in the literature. as the investigators have considered that costotransverse block can be efficacious for providing postoperative analgesia in the breast surgeries, the investigators have implemented the application of this blockade into practice at the clinic. the main purpose of this study is to evaluate the analgesic effect of ultrasound-guided unilateral costotransverse block in breast cancer surgery.


Eligibility criteria:
inclusion criteria: * patients undergoing breast canser surgery under general anesthesia asa i-ii exclusion criteria: * patients undergoing breast surgery under paravertebral block and others morbidly obesity asa iii - iv infection of the skin at the site of needle puncture area patients with known allergies to any of the study drugs coagulopathy recent use of analgesic/steroid drugs

Keywords: ultrasound guided block
imaging malignant glioma with 68ga-dotatoc pet/ct

Conditions: Glioma

Summary: the purpose of this study is to characterize tumour uptake of somatostatin analog 68ga-dotatoc in patients with either primary or recurrent malignant glioma. the investigators hypothesis is that some primary and recurrent malignant gliomas overexpress sst2 receptor which can be imaged with 68ga-dotatoc pet/ct. the investigators also hypothesize that tumor uptake of 68ga-dotatoc correlates with immunohistochemically determined sst2 receptor status of the tumor specimen.


Eligibility criteria:
inclusion criteria: * age: 18 to 70 years old * language spoken: finnish or swedish * performance status: karnofsky score 70 or better or who performance status 2 or better * supratentorial malignant glioma based on mri imaging * supratentorial recurrent glioma based on mri and/or \[11c\]methionine pet imaging * patients must be able to understand the meaning of the study and sign the appropriate ethical committee approved informed consent documents in the presence of the designated staff exclusion criteria: * any medical or psychiatric condition that compromises the subject´s ability to participate in the study * any other significant disease including liver or renal disease * pregnant or lactating women

Keywords: glioma 68ga-dotatoc pet/ct somatostatin receptor
using a patient navigator to address the social drivers of health in the management of pain

Conditions: Pain

Summary: the purpose of this study is to see if patients with chronic pain can improve how they manage their pain and daily function by working with a care manager and by learning pain coping skills from an online teaching tool.

this study will determine the effects of patient navigator-delivered care coordination to address the major social drivers of health on pain-related outcomes. all participants will have access to web-based cognitive behavior therapy (paintrainer) - a self-guided program that contains 8 modules, lasting 30-40 minutes each and can be completed in 8 to 12 weeks. each module teaches behavioral coping strategies for pain management and recommends practice exercises. some participants will also receive phone call visits with patient navigator to coordinate care.

Eligibility criteria:
inclusion criteria: * patients with daily pain for 3 months or longer * chronic daily musculoskeletal pain with pain, enjoyment, general activity (peg) survey score \>=4 * primary care provider must be an atrium provider * has at least one social driver of health: financial insecurity, work and income, housing, food insecurity, safety, health literacy and at least one of the above, lack of social support and at least one of the above exclusion criteria: * patients who have active cancer * cognitive impairment severe enough to preclude participation in a behavioral/lifestyle change program * live in a nursing home or inpatient treatment facility * unable to read and converse in english * those who are already connected to a patient navigator or nurse coordinator or social worker * planned elective surgery in the next 6 months

Keywords: daily pain musculoskeletal pain pain management
racing and crowded thoughts in mood disorders

Conditions: Bipolar Disorder

Summary: racing thoughts relate to subjective acceleration of thinking which has been essentially associated with manic episodes in bipolar disorder. qualitatively, the phenomenology of racing thoughts in major depression seems to differ from rumination and pure manic racing thoughts: thoughts of all kinds accumulate in the patient's head. recent qualitative evidence is consistent with the existence of these two kinds of "thought overactivity" related to mood disorders. in order to evaluate this and better understand the psychopathological and cognitive mechanisms that underlie thought overactivity in mood disorders, we have created a 34-item self-questionnaire - the racing and crowded thoughts questionnaire (rctq) and a number of neuropsychological tasks (time perception, cognitive flexibility). also, given the relationship between mood disorders and creativity, it is likely that thought overactivity is related to increased creativity. we aim at evaluating this relationship through the french version of the cognitive processes associated with creativity scale (cpac).


Eligibility criteria:
inclusion criteria: * bipolar disorder or depressive disorder * 18 -65 years old exclusion criteria: * neurological conditions or sequelae * substance abuse in the last 10 months * schizophrenia * adhd * borderline personality disorder * pregnant women- subjects under legal supervision
tailored cognitive-behavioral therapy for fibromyalgia patients at risk

Conditions: Fibromyalgia

Summary: the present study is a new approach of examining tailored cognitive-behavioral interventions for fibromyalgia patients at risk. for this purpose, fibromyalgia patients are screened with respect to cognitive-behavioral risk factors and these patients are offered tailored cognitive-behavioral treatment options. it is expected that this approach will result in increased magnitude and maintenance of effects.

the fibromyalgia syndrome is a chronic condition with widespread pain that poses a great challenge for patients, rheumatologists and society because of the lack of optimal treatment options. there is extensive evidence that, in comparison with patients with rheumatoid arthritis, fibromyalgia patients report higher levels of functional disability, pain, fatigue, and lower levels of quality of life. although effectiveness of pharmacological agents and other interventions is generally limited, most promising effects have been found for non-pharmacological treatments, particularly those with a primary focus on cognitive-behavioral treatment components. however, also these treatment outcomes are characterized by large individual variation. particularly patients with less impairments in daily life seem to benefit less from these treatments. in line with the international literature, previous findings of the research group suggest that effectiveness might be increased when tailored cognitive-behavioural treatments are solely offered to patients at risk. in the present project the effects of tailored interventions based on cognitive-behavioral factors for patients at risk are studied. in a randomized, controlled trial, fibromyalgia patients are screened for risk profiles. patients at risk will be assigned to tailored cognitive or behavioral treatment conditions, depending on their risk profile with respect to cognitive-behavioral factors. half of the patients are subsequently randomly assigned to a waiting list control condition. it is expected that this tailored treatment approach will increase magnitude and maintenance of treatment effects for pain, disability, fatigue and increased quality of life, which means an important step forward for patients, involved professionals and society.

Eligibility criteria:
inclusion criteria: * fibromyalgia according to the criteria of the american college of rheumatology (acr) exclusion criteria: * physical or psychological comorbidity that interferes with cognitive-behavioral treatment * participation in other clinical trials * other psychological treatments * pregnancy * illiteracy * difficulties with understanding dutch language

Keywords: fibromyalgia cognitive-behavioral therapy tailored treatment
safety of two trivalent influenza vaccines evaluated in children and adolescents 4 to 17 years of age

Conditions: Influenza; Fever

Summary: evaluate safety and tolerability of tiva or tivb vaccine in healthy children and adolescents 4 to 17 years of age.


Eligibility criteria:
inclusion criteria: - healthy subjects 4-17 years of age exclusion criteria: * subjects who are not healthy, * subjects who are pregnant or breast feeding, * subjects with a history of severe allergic reaction or allergic to any of the vaccine components.

Keywords: influenza children and adolescents trivalent vaccine cell culture embryonated chicken eggs
impact of the use of crp on the prescription of antibiotics in general practitioners

Conditions: Respiratory Infection; Respiratory Infections in Children

Summary: respiratory infections, including episodes of coughing with fever, are the main cause of outpatient antibiotic prescription, while a minority of them are linked to bacterial infections requiring antibiotic. these prescriptions are often performed by general practitioners. these unnecessary antibiotic contribute to increased bacterial resistance, side effects and unnecessary costs. campaigns for the correct prescription of antibiotics have had a real but partial or transient success. c-reactive protein micro-method (poct-crp) could help to differentiate between viral and bacterial infections and thus contribute to the proper use of antibiotics. the decrease in prescription of antibiotics is likely to have an even stronger positive impact in countries like france, where prescription is high. the objective of this study is to evaluate the use of poct-crp in the general practitioner's office in case of suspected respiratory infection.


Eligibility criteria:
inclusion criteria: * age ≥ 3 years * clinical suspicion of respiratory infection defined by the presence of at least one respiratory sign among, cough, dyspnea, chest pain and auscultatory abnormality and at least one general sign among fever, sweat, headache, myalgia, impairment of general condition * affiliated to a social health insurance * signed consent exclusion criteria: * duration of symptoms \< 24 hours * hospitalization or emergency assessment decision decided from the outset * signs of severity before the realization of poct-crp * patient previously included in the study for the same episode * antibiotic therapy within 7 days * chronic cough (more than 3 weeks)

Keywords: respiratory infections c-reactive protein antibiotic prescription
hypotensive effect of anaesthesia with tci

Conditions: Blood Pressure; Hypotension

Summary: hypotension will often complicate induction of anaesthesia. the investigators want to test the hypothesis that target controlled infusion, as opposed to velocity controlled infusion, leads to less degree of hypotension.

severe hypotension may be a serious complication to induction of anaesthesia. the patients preoperative clinical circulatory status will help define the risks of such a side-effect. a patient with a preexisting heart condition will be at increased risk for morbidity/mortality in relation to anaesthesia induction. total intravenous anaesthesia may be delivered by two different approaches. the old way where the drug (propofol and/or remifentanil) is delivered in a velocity (mg/kg x hour or microg/ kg x min) specified by the anaesthetist. hereafter called velocity controlled infusion (vci). at induction, to get effect of the drug, a high infusion rate is desired. a high infusion rate is associated with increased risks of hypotension if it is not adjusted in accordance with the current circulatory status of the patient. a failure to adjust may be futile for the patient. therefore, induction takes some time because infusion rate is set within a relatively safe range. after a few minutes, once airway control is achieved, the infusion rate must be adjusted down to avoid hypotension. there is a more modern way of adjusting the infusion rate, the so called target controlled infusion. with this approach, the pump delivering the drug will help the anaesthetist to select the appropriate infusion rate for any given situation. the anaesthetist selects a preferred concentration of the drug at the target, that is in the circulation. the pump then administrates the drug, first at high rate and then at lower rate, taking into account the patients age, weight and sex and the preferred target concentration. it is possible that this help from the machine is associated with less risk for hypotension at anaesthesia induction. if this is so it would have an impact on which of tci and vci that would be the best choice of anaesthesia. this would have special impact when giving anaesthesia to patients with a heart condition.

Eligibility criteria:
inclusion criteria: \* all patients scheduled for anaesthesia at östersunds hospital * asa class i-ii exclusion criteria: * on beforehand decision to start continous delivery of blood pressure increasing drug at induction. * any contraindication to total intravenous anaesthesia
nociception and bis level monitoring in covid-19 patients in the intensive care unit

Conditions: Nociceptive Pain

Summary: pain (nociception), stress and discomfort are difficult to detect in sedated and intubated patients during mechanical ventilation. in order to improve this several nociception level monitors (nol) were developed that objectively track nociception in sedated or anesthetized patients. earlier studies showed that for sedated and intubated patients in the operating room, using such monitors is beneficial in reducing stress hormones and post operative pain scores. in this study the investigators aim to observe whether the nol could be equally beneficial in managing nociception in sedated and intubated icu patients.

to date it remains challenging to adequately titrate analgesic medication in sedated and anesthetized patients. recently, nociception monitoring was introduced to guide analgesic treatment in sedated and anesthetized surgical patients. one such monitor is the nociception level (nol; medasense biometrics ltd., israel). the nol combines various measurements such as, skin conductance, heart rate, heart rate variability and photoplethysmograph amplitude, and translates these inputs into a single index ranging from 0 (no nociception) to 100 (maximal nociception). earlier studies have shown that during surgery, the nol-guided opioid treatment resulted in improved hemodynamics and reduced postoperative pain. in the covid-19 pandemic, patients admitted in the intensive care unit (icu), needed excessive amounts of sedatives, analgesics and muscle relaxants during mechanical ventilation. to determine its value in the icu, the investigators measured nol values in covid and non-covid icu patients in an earlier study. the aim of the investigators was to verify the assumption that covid-19 patients were overdosed on opioids. since the investigators indeed did observe lower nol values in covid-19 patients than in non-covid patients in an earlier study, the investigators expanded the study to determine whether sedatives were equally overdosed, by also measuring the bispectral index (bis). with this extra information the investigators also hope to determine whether it is feasible to use the nol in the icu.

Eligibility criteria:
inclusion criteria: * aged 18 years or older * mechanical ventilation for any reason * deemed suitable by the investigators exclusion criteria: * aged 17 years or younger * severe peripheral edema * veno-arterial (va) and veno-venous (vv) exctracorporeal membrane oxygenation (ecmo) * heart rate below 35 * abdominal position * not deemed suitable by the investigators
[68ga]ga dota-5g as a diagnostic imaging agent for metastatic/advanced invasive lobular breast cancer (lbc)

Conditions: Metastatic Lobular Breast Carcinoma

Summary: this is a prospective study using \[68ga\]ga dota-5g pet/ct imaging in patients diagnosed with metastatic/advanced invasive lobular breast cancer (lbc).

this is a phase i investigator-initiated study that will investigate \[68ga\]ga dota-5g in patients with metastatic/advanced invasive lbc. 30 patients diagnosed with lbc will be enrolled over a 24-month period. we hypothesize that a) \[68ga\]ga dota-5g will detect lesions in patients with invasive lbc, b) \[68ga\]ga dota-5g will be safe and well tolerated, and that c) \[68ga\]ga dota-5g pet/ct is more sensitive than 18f-fdg pet/ct at detecting lesions.

Eligibility criteria:
inclusion criteria: * (ability to understand and willingness to sign a written informed consent document. * men and women age ≥ 18 yrs * confirmed presence of metastatic/advanced invasive lobular breast cancer and measurable disease per recist (version 1.1) * available archival tumor tissue * eastern cooperative oncology group performance status ≤ 2 * hematologic parameters defined as: absolute neutrophil count (anc) ≥ 1000 cells/mm3,platelet count ≥ 100,000/mm3, hemoglobin ≥ 8 g/dl. * blood chemistry levels defined as: ast, alt, alkaline phosphatase ≤ 5 times upper limit of normal (uln), total bilirubin ≤ 2 times uln, creatinine clearance \>60 ml/min. * anticipated life expectancy ≥ 3 months * able to remain motionless for up to 30-60 minutes per scan. exclusion criteria: * pregnant and lactating women * prisoners * concurrent malignancy of a different histology that could confound imaging interpretation. * patients who cannot undergo pet/ct scanning because of weight limits(\>350lbs)