Kornimate/medical-research-clean huggingface dataset:
development of three dimensional preoperative planning system for the osteosynthesis of distal humerus fractures

Conditions: Distal Humerus Fracture

Summary: to reproduce anatomical reduction and appropriate implant placement/choices during osteosynthesis for elbow fractures, a 3d preoperative planning system was developed. to assess the utility of 3d digital preoperative planning for the osteosynthesis of distal humerus fractures, the reproducibility of implant reduction shapes and placements in patients with distal humerus fractures will be evaluated.

3d preoperative planning will be applied for four distal humerus fracture cases . the preoperative planning will be performed in order to determine the reduction, placement and choices of implants. after the operation, the accuracy of the reduction and implants choices and placements will be verified. the reductions will be evaluated with an angle between the diaphysis axis and a line connecting the medial epicondyle with the lateral epicondyle and an angle between the diaphysis axis and the articular surface in the coronal plane and distance between the anterior diaphysis and the anterior articular surface in the sagittal plane for the 3d images of distal humerus. the reproducibility will be evaluated by the differences of the parameters between pre- and post-operative images.

Eligibility criteria:
inclusion criteria: * distal humerus fracture patients exclusion criteria: * patients with a previous history of traumatic injuries to the elbow
sleep loss and glucose metabolism in people with family history of type 2 diabetes.

Conditions: Sleep; Sleep Deprivation; Insulin Resistance; Type 2 Diabetes

Summary: the use of sugar and starch-like foods for energy (carbohydrate metabolism) changes when people sleep. however, it is still not known if differences in the amount of nighttime sleep have an effect on the carbohydrate metabolism of people who have a relative with type 2 diabetes (parent, sibling, or grandparent). this study is being done to test the hypothesis that the carbohydrate metabolism of people who have a history of type 2 diabetes in their family will be different after they have slept short hours for 10 days in comparison to when they have slept longer hours for 10 days.

study participants will complete two 10-day inpatient stays in the sleep laboratory of the university of chicago clinical resource center scheduled at least 4 weeks apart. bedtime duration will be set at 5 hours per night during one of these stays and 8.5 hours per night during the other. no daytime naps will be allowed. study participants will be served regular daily meals including breakfast, lunch, dinner, and a bedtime snack. on weekdays all participants will engage in simulated "office work" while in the sleep laboratory. during the rest of the time participants will maintain their usual indoor and outdoor activities as much as possible within the limits of the university of chicago campus. during the last two days of each inpatient stay in the laboratory, participants will undergo two different tests. the first test will determine how much insulin does their body produce in response to an intravenous glucose infusion lasting several hours. the second test will determine how effective is the action of the sugar-processing hormone, insulin, in their body when it is infused intravenously together with glucose over a period of several hours.

Eligibility criteria:
inclusion criteria: * regular sleep habits * bmi 20 to 27 kg/m2 * at least one parent, sibling or grandparent with type 2 diabetes * no regular exercise habits exclusion criteria: * active smoker * night or shift work * have highly variable sleep habits * have a hormonal disorder * have a sleep disorder * have an active medical problem * women only: use of birth control pills * women only: irregular menstrual periods or pregnancy * use of medications/compounds that can disrupt sleep

Keywords: short sleep duration glucose clamp technique insulin secretion insulin action lipid turnover free fatty acids
a non-interventional study evaluating clinical utility and implications on improved patient management of serum neurofilament as a prognostic marker for disease activity in patients with relapsing multiple sclerosis

Conditions: Multiple Sclerosis

Summary: this is a prospective, multicenter, observational, non-interventional study (nis) in patients with multiple sclerosis (ms) and routinely assessed serum neurofilament light (snfl) values in germany

prospective, primary data will be collected from patients with snfl outcomes in the context of switching to ofatumumab or continuing their current therapy. data collection will cover a maximum period of 24 months. the observational period will not be dictated by the protocol. baseline and follow-up visits will take place at a frequency defined as per investigator´s discretion following clinical routine. the diagnostic or monitoring procedures are only those ordinarily applied to therapeutic strategy and routine clinical care. during the observation phase of the study, data will be collected according to standard of care as recommended by kknms (competence network multiple sclerosis in germany). eligible participants for the study are patients who have received treatment with category 1 dmts and those who have included snfl into their treatment decision-making process. these patients have the option to either continue their current dmt or switch to ofatumumab. according to local treatment guidelines, dmt category 1 include dimethylfumarate/diroximelfumarate, glatirameroids, interferon beta and teriflunomide. the decision to switch to ofatumumab or to continue the current dmt category 1 therapy must be made by the treating physician independently of the decision to enroll the patient in the study.

Eligibility criteria:
inclusion criteria: participants eligible for inclusion in this study must meet all the following criteria: 1. written informed consent must be obtained before participation in the study. 2. rms patients aged 18 or older. 3. treated in label with eu-approved dmts for ms category 1 according to current guidelines (hemmer et al 2023) for at least the last 3 months. 4. presence of a snfl test result from a commercially available test not older than 3 months. exclusion criteria: participants meeting any of the following criteria are not eligible for inclusion in this study: 1. patients being treated outside of the approved label of the respective dmt. 2. simultaneous participation in any interventional study or simultaneous participation in another novartis-sponsored non-interventional study with ofatumumab.

Keywords: multiple sclerosis ms ofatumumab nis germany
surgical management of posterior tibial plateau fractures

Conditions: Tibial Fractures

Summary: this protocol concerns an academic, multicentric, and prospective clinical trial. in this study the investigators will evaluate the recently approved wave-plate (7s medical) for open reduction and internal fixation and buttressing of the posterior proximal tibial column via a posteromedial reversed l-shaped approach. the reversed l-shaped approach has been shown as a safe technique with adequate visualisation of the posterior tibial surface. the investigators will thoroughly evaluate all important clinical, radiological and functional variables. the functional outcome will be reported in patient reported outcome measures by means of the validated knee injury and osteoarthritis outcome score (koos).


Eligibility criteria:
inclusion criteria: * tibial plateau fracture with involvement of posterior proximal tibial plateau (according to revised three-column classification), requiring osteosynthesis exclusion criteria: * absent contact information * living abroad and cannot participate in the follow-up visits * non-functional leg prior to treatment/injury * pathological fractures * bilateral fractures

Keywords: classification questionnaires open reduction internal fixation
radial artery function following trans-radial cardiac catheterisation

Conditions: Atherosclerosis

Summary: the investigators will study radial artery injury and endothelial function following trans-radial cardiac catheterisation. radial artery injury will be quantified pre- and post- angiography using optical coherence tomography. the participants will also have radial endothelial function assessed using flow-mediated dilatation at baseline, 24 hours, one week, one month and three months post- angiography. blood will be taken pre and 24 hours post angiography for characterisation of endothelial progenitor cell numbers and function. the hypothesis is that trans-radial catheterisation will cause a reduction in flow-mediated dilatation which peaks at 24 hours and recovers at three months. the investigators hope to correlate the rate of this recovery with peri-procedural progenitor cell numbers.


Eligibility criteria:
inclusion criteria: * stable outpatient population aged between 18-85 attending for trans-radial cardiac catheterisation exclusion criteria: * recent myocardial infarction (\<3 months) * severe aortic stenosis * chronic renal failure (egfr\<30) * inability to give informed consent
correlation of disease management and quality of life in patients with chronic heart failure and their family caregivers

Conditions: Chronic Heart Failure

Summary: this study intends to investigate the current status of disease management and quality of life of patients with chronic heart failure and their family caregivers, explore the relationship between the two sides of disease management and quality of life, help nurses identify the influencing factors of quality of life of patients with chronic heart failure and their family caregivers, and carry out family-centered care in the future. this study intends to investigate the current status of disease management and quality of life of patients with chronic heart failure and their family caregivers, explore the relationship between disease management and quality of life of both sides, and help nurses identify the influencing factors affecting the quality of life of patients with chronic heart failure and their family caregivers, so as to carry out family-centered care in the future. to provide theoretical basis for improving the quality of life of both parties.


Eligibility criteria:
inclusion criteria: 1. meet the diagnostic criteria of chinese guidelines for the diagnosis and treatment of heart failure 2. the duration of chronic heart failure was ≥3 months; 3. have certain reading, comprehension and expression ability, and can complete the questionnaire independently or with the guidance of the researcher; 4. informed and agreed to participate in the investigation exclusion criteria: * in the acute stage of the disease, such as acute heart failure attack or complicated with severe pulmonary infection, liver and kidney function damage, etc.
treatment of adhd with atomoxetine in children & adolescents with adhd & comorbid dyslexia

Conditions: Attention Deficit Hyperactivity Disorder; Dyslexia

Summary: this study will evaluate the effect of atomoxetine in treating attention-deficit/hyperactivity disorder (adhd) symptoms in children and adolescents with adhd and comorbid reading disability (dyslexia)


Eligibility criteria:
inclusion criteria: * patients must meet diagnostic and statistical manual of mental disorders fourth edition (dsm-iv) criteria for attention-deficit/hyperactivity disorder (adhd) * patients must achieve a score of 80 or more on the full scale intelligence quotient * child or adolescent patients must be 10 to 16 years old * must be able to communicate in english * must be able to swallow capsules * be reliable to keep appointments for clinic visits and all related tests exclusion criteria: * patients who weigh less than 25 kg or greater than 70 kg * patients with a history of alcohol or drug abuse on a repeated basis within the past 3 months * patients with documented history of autism, asperger's syndrome or pervasive developmental disorder * females who are pregnant or breastfeeding * patients with a history of severe allergy to more than one class of medications * patients with documented history of bipolar i or bipolar ii disorder, or psychosis
the effect of pomegranate juice on oxidative stress in hemodialysis patients

Conditions: End Stage Renal Disease; Hemodialysis

Summary: pomegranate juice (pj) consumption by hemodialysis patients will reduce the oxidative stress and the incidence of infections, cardiovascular events and mortality.

the mortality rate in patients with end stage renal failure is substantially higher than in the general population, and deaths are mainly attributable to cardiovascular diseases and infections. there is accumulating evidence that supports the role for oxidative stress in damaging the immune system and in the pathogenesis of cardiovascular diseases in hemodialysis patients, therefore antioxidative treatment, which will reduce oxidative stress, may be beneficial. pomegranate juice contains antioxidants such as soluble polyphenols, tannins and anthocyanins and was shown to have anti-inflammatory, anti- bacterial and anti-atherosclerotic properties in mice and humans. however,the effects of pomegranate juice on oxidative stress, infections and cardiovascular events in hemodialysis patients are still not documented. this is a randomized preventive intervention trial on hemodialysis patients from one dialysis centre in israel. the patients will be enrolled and randomized to receive pomegranate juice or placebo. patients will be followed for one year. the objective of this study is to investigate the effects of pomegranate juice (pj) consumption by hemodialysis patients on the changes in oxidative stress and the incidence of infections, cardiovascular events and mortality.

Eligibility criteria:
inclusion criteria: * end stage renal disease, stable chronic hemodialysis \> 3 months * informed consent. * man and women over 18 years. exclusion criteria: * hemodialysis \< 3 months * participation in other clinical trial * not eligible according to physician decision

Keywords: hemodialysis nephrology pomegranate juice israel
epidemiology of resistant microbial strains among different groups of people (healthy, infected and exposed to animals)

Conditions: ESBL Producing E.Coli; ESBL Producing K.Pneumoniae; Multidrug Resistant P.Aeruginosa; Carbapenem Resistant P.Aeruginosa; Methicillin Resistant Staphylococcus Aureus (MRSA); Vancomycin (Glycopeptide) Resistant Enterococcus (VRE)

Summary: this study investigates carriage rate and risk factors for acquiring multiresistant bacteria (esbl producing e.coli and k.pneumoniae, carbapenem-resistant and multidrug resistant p.aeruginosa, mrsa and vre) in hospitalised patients and healthy volunteers.


Eligibility criteria:
i group hospitalised patients inclusion criteria * mdr bacteria (listed above) isolated from clinical specimen * hospitalisation to the tartu university hospital or north estonia medical centre or west tallinn central hospital or east-tallinn central hospital or the hospital of reconstructive surgery ii group healthy volunteers inclusion criteria * age \>6 months * have not received any antibacterial treatment in previous 3 months * have not been hospitalised in previous 3 months iii group dog owners inclusion criteria * age \>6 months * have not received any antibacterial treatment in previous 3 months * have not been hospitalised in previous 3 months * owning a dog iv group veterinarians inclusion criteria * have not received any antibacterial treatment in previous 3 months * have not been hospitalized in previous 3 months * working as a veterinarian v group pig farmers inclusion criteria * have not received any antibacterial treatment in previous 3 months * have not been hospitalized in previous 3 months * occupation as a pig farmer
contribution of contrast enhanced ultrasound in the diagnosis of adnexal torsion

Conditions: Adnexal Torsion

Summary: clinical diagnosis of adnexal torsion is difficult because the symptomatology is dominated by abrupt onset pelvic pain, an aspecific sign which does not allow a diagnosis of certainty to be made. to confirm the diagnosis, the reference examination is pelvic ultrasound with doppler flow analysis. however, its intake is low, its sensitivity varies from 46 to 73% depending on the studies. other imaging techniques have been considered, such as mri, with a sensitivity far superior to ultrasound, but its difficult accessibility, in particular in the context of an emergency, makes it unusable in clinical practice. the use of ultrasound with the injection of an ultrasound contrast agent, strict intravascular, seems to be an interesting technique to assess the perfusion parameters of the ovary and improve the diagnostic sensitivity of the adnexal torsion. its interest has already been demonstrated in the diagnosis of testicular torsion in animals but to date, no study has evaluated its contribution in adnexal torsion.

the primary objective is to evaluate the diagnostic performance of contrast enhanced ultrasound for the diagnosis of adnexal torsion in women with suspected adnexal torsion. the secondary objectives are: 1. to describe the perfusion parameters of the ovaries by contrast enhanced ultrasound 2. to compare performance diagnosis of contrast ultrasound and bidimensional doppler for the detection of adnexal torsion. 3. to describe the perfusion parameters of the ovarian as a function of the degree of adnexal torsion. 4. to compare perfusion parameters before and after ovarian detorsion 5. to describe perfusion parameters of the ovarian by using microvascular flow technique 6. to assess the contribution of qualitative contrast ultrasound for the diagnosis of adnexal torsion (without clinical context) 7. to assess inter-observer agreement on the qualitative analysis of ultrasound, without clinical context and then with clinical context.

Eligibility criteria:
inclusion criteria: * woman over 18 years old * woman affiliated to a social security * woman having received complete information on the organization of the research and having given her informed consent in written form. * planned surgical intervention for suspected adnexal torsion exclusion criteria: * patients under a measure of legal protection, * contraindication to contrast injection hypersensitivity to sulfur hexafluoride or any of the other ingredients, history of cardiac disease, respiratory distress syndrome, severe pulmonary hypertension..

Keywords: adnexal torsion ovarian contrast enhanced ultrasound
incisional hernia progression over time

Conditions: Hernia, Ventral

Summary: this is a prospective multicenter study of patients diagnosed with a medium to giant incisional hernia (transverse defect \>7 cm). patients referred to the surgical outpatient clinic are invited to participate in the study. as a standard, all patients who are examined for incisional hernia undergo ct scan according to a hernia protocol, before planning of surgical repair (baseline scan). after this ct scan, patients are seen in the out-patient clinic once again and either treated conservatively without surgery, or scheduled for elective surgical repair of the hernia. if surgery is planned, the patients participating in the study undergo an additional ct scan in hernia protocol, within two weeks prior to surgery (follow-up scan). if a conservative non-surgical approach is chosen, patients can still participate in the study and will undergo an additional ct scan after 28-32 weeks.

this is a prospective multicenter study of patients diagnosed with a medium to giant incisional hernia (transverse defect \>7 cm). patients referred to the surgical outpatient clinic are invited to participate in the study. as a standard, all patients who are examined for incisional hernia undergo ct scan according to a hernia protocol, before planning of surgical repair (baseline scan). after this ct scan, patients are seen in the out-patient clinic once again and either treated conservatively without surgery, or scheduled for elective surgical repair of the hernia. if surgery is planned, the patients participating in the study undergo an additional ct scan in hernia protocol, within two weeks prior to surgery (follow-up scan). in case no baseline scan in hernia protocol exists, patients will undergo this scan immediately after inclusion in the study. furthermore, patients will be asked to fill out a questionnaire on physical activity (ipaq) and hernia-related quality of life (herqles) at the time of the baseline and follow-up scans. ipaq is a well-validated questionnaire, which assesses patients' physical activity within the last 7 days. the outcome is metabolic minutes per week, a numerical value which places the responder in one of three categories: low, moderate or high physical activity. herqles is a validated questionnaire assessing the hernia-related quality of life. this questionnaire has been translated into danish using a standardized protocol. the outcome is a numerical score of 0-100, with 100 being the highest hernia-related quality of life. currently, the time from planning of hernia repair to surgery is approximately 30 weeks. thus, the mean time between the two ct scans should be around 28-32 weeks. if a conservative non-surgical approach is chosen, patients can still participate in the study and will undergo an additional ct scan after 28-32 weeks.

Eligibility criteria:
inclusion criteria: * suspected incisional hernia with a horizontal fascial defect \> 7 cm exclusion criteria: * inability to read or speak danish
oral dexmedetomidine vs midazoam for premedication

Conditions: Premedication

Summary: the aim of this study was to compare the effect of 2 µg/kg of oral dexmedetomidine (dex) and 0.5 mg/kg dormicum as premedication among children undergoing dental procedures.

the study involved 52 children between 3-7 years of age, asa i , who underwent full-mouth dental rehabilitation. the dex group (n=26) received 2 µg/kg dex in apple juice, and the control group (n=26) received 0.5 mg/kg midazolam in apple juice. the patients' scores on the ramsey sedation scale (rss), parental separation anxiety scale, mask acceptance scale, post-anesthesia emergence delirium scale (paeds), and hemodynamic parameters were recorded. the data were analyzed using chi-square test, fisher's exact test, student t test, and analysis of variance in spss.

Eligibility criteria:
inclusion criteria: * the inclusion criteria is age between 3 to 7 years and american society og anesthesiology (asa) grade 1. exclusion criteria: * the exclusion criteria included congenital disease, dex, propofol allergy, asthma, mental retardation and those children parents refuse to participate study.

Keywords: premedication
the influence of anterior chamber fluid mediators on the success rate of trabeculectomy

Conditions: Glaucoma; Trabeculectomy; Wound Healing

Summary: the aim of the study is to investigate whether it is possible to predict the success of trabeculectomy in patients with glaucoma through the examination of mediators of wound healing in anterior chamber fluid. the success rate of trabeculectomy with mitomycin c in the literature is about 75%. this leads on the question why 25% of the patients received trabeculectomy are not sufficient treated and have not a long-term iop reduction. precisely this question is to be examined by the study.


Eligibility criteria:
inclusion criteria: * patients with glaucoma with a trabeculectomy required * 60 eyes of 60 patients, the ratio of female / male is not involved. * eye pressure under local therapy: 20mmhg and above (corrected with pachymetry table). * age of at least 18 years exclusion criteria: * all patients not included in the group of inclusion criteria. * less than 50yl anterior chamber fluid could be collected during the operation.

Keywords: glaucoma