Kornimate/medical-research-clean huggingface dataset:
spasticity multidisciplinary management : qol and physical activity measurement with connected health devices (peps)

Conditions: Spastic Foot

Summary: peps is a 18 months prospective bicentric study on 30 patients with spastic foot. the main objective is to evaluate the mean daily gait perimeter modifications mesured by connected watch, 6 months after spastic equinus foot surgery versus before this surgery. investigator will lend a connected watch during the first consultation, and the patient will use it during 10 days in order to collect his mean daily gait perimeter. a lot of other tests will be realised in order to caracterize the clinical picture of each patient. after patients will be operated and all caracteristics of the surgery will be collected. finally, at 6 months appointment, investigator will do the same analysis than first appointment in order to comparate the data for functional prognosis.

the study is proposed to eligible patients after a pluridisciplinar specialised appointment in the neurosurgery ward, realised by a neurosurgeon, an orthopedist and a prm physician. after spastic equinus foot diagnosis needed surgery et after patient's consent to the surgery, investigator will proposed to patient to participate at our study. before surgery, demographic datas, spasticity clinical datas, clinical examination (ashworth and penn scale), past treatments are collected. other investigations are realised : fim, nfac, rivermead mobility index, lower extremity functional scale, sf36, eq5d. gait perimeter are collected by the connected watch, and also with a 10 meters test, the gait perimeter on flat and level ground which is unencumbered by any obstacles, gaitrite evaluation. patient will conserved the connected watch during all the study duration. peroperative datas are collected for each pateints with 3 times. first, before surgery, investigator collect joint range of motion under general anesthesia but without curarization. second, during surgery, the surgical technique is described, with which nerves and which muscles are treated. finally, after surgery, investigator will de novo collect joint ranges with the same clinical conditions. at 6 months appointment, routine datas are collected (surgical complications, clinical examination) and also the notified investifations (fim, nfac ...), clinical investigations (gaitrite, connected watch datas ...)

Eligibility criteria:
inclusion criteria: * over 18 years old * walking patient * spastic foot surgery indication * consent form ok * patient with ios or android mobile phone exclusion criteria: * previous spastic surgery * psychiatric disease * pregnancy

Keywords: spasticity spastic foot podometer neurosurgery
accuracy evaluation of earlysense with modified sensor (smaller shape sensor with ble) at home setting monitoring a subject while partner in bed

Conditions: Sleep Disorder

Summary: accuracy evaluation of earlysense device, a smaller shape sensor with ble connection to processing unit (hub)) for use while two people are in bed ("home use" scenario) the earlysense device is intended for continuous contact-free monitoring of heart rate and respiration rate at home, or in professional healthcare settings. the system is intended for remote monitoring of patients by healthcare professionals and is indicated mainly for elderly population monitoring. the modified version of this product which is the subject of this validation study allows monitoring of subjects when there is a second person in the same bed ("home scenario" environment). the objective of this study is to evaluate the accuracy of the device in determining respiration rate (br./min) and heart rate (bpm) at home environment, while two people are in the same double bed. the study aims to demonstrate that partner presence doesn't affect the monitoring accuracy of the subject that is being measured. the continuous monitoring will last for duration of 90 minutes for each subject, unless the participant requests termination of the experiment or as per the physician's instructions. subjects admitted to the study will be monitored using both capnography and ecg- as reference devices. the earlysense revised sensor will be placed under one of the two-mattress types incorporated into the study. both mattresses are typical double bed mattresses of 160 x 200 cm with two different internal structure composition. the sensor will be placed directly below the subject's thorax area on one of the mattress sides. the signals collected by the sensor will be communicated via ble to the processing unit (hub). following connecting the subject to the reference devices, both the subject and the partner will be instructed on the actions they should perform through the stages of the experiment. the subject will lie on the mattress side where the earlysense sensor is located, while the partner will be instructed to enter the other side of the mattress. at this time, the experiment will start, and the clock will start running.


Eligibility criteria:
inclusion criteria: * age above 18 years * sleeping with a partner in bed * willing to sign the consent form exclusion criteria: * subjects with arrhythmia will be excluded from the study
social cognitive development in young children with autism

Conditions: Autism Spectrum Disorder

Summary: through the development of a novel treatment targeting core autism spectrum disorder (asd) social deficits and studying the efficacy of this intervention, the investigators hope to provide a means for children with asd to more effectively and efficiently process social information and enable them to more successfully engage in social interactions. children between the ages of 24 and 36 months and their families may join.


Eligibility criteria:
inclusion criteria: * participants must be 24 to 42 months old * children must meet criteria for asd or autism on the ados (lord et al., 2000) plus receive a clinical judgment of pdd-nos or autism by the study team * score ≥ 16 months on the visual receptive subtest and ≥ 9 months on the receptive language subtest on the mullen scales of early learning and/or the vineland adaptive behavior scales at the time of eligibility testing. * the parent (or other primary caregiver, such as grandparent) in the pe condition must agree to attend the training sessions each week for the 5-month period. * the parent must agree to bring their child in for testing at all testing points (pre-testing, post-testing, follow-up testing). * parents must be between the ages of 18 and 65 years old * it is not required that english be their primary language, but they must be fluent in english (or if the child is nonverbal he/she must hear english most of the time at home) exclusion criteria: * \ 42 weeks gestational age * \<2500 grams birth weight, severe birth trauma * head or serious bodily injury sustained before or during the study * illicit drug or excessive alcohol exposure (defined in our telephone screening interview) * major hearing or visual impairment * non-febrile seizures * any known genetic syndrome * mitochondrial disorders * severe birth defects * no foster children may participate * the child must not be adopted * the child must not be participating in another intervention study simultaneously or be simultaneously enrolled in the card clinic's achievements, early achievements, tips, jump start, or play with me programs. * unable to provide baseline data on the eye tracking measure at time of pretesting (e.g., tracker unable to read eye movements) * has a sibling participating in this study

Keywords: autism spectrum disorder language social toddlers
cuff pressure regulation apparatus for tracheal intubation in children

Conditions: Cuff Overinflation; Cuff Underinflation

Summary: despite the expert recommendation about rigorous monitoring of tracheal cuff pressure using a continuous or intermittent technique, cuff underinflation and overinflation are common increasing the risk of microinhalation and tracheal ischemia. all these complications are associated with high morbidity and mortality in icu.

in this study, the investigators will compare the duration of the period of under-inflation and over-inflation between electronic (vbm©) and pneumatic (nosten©) devices (continuous monitoring of tracheal cuff pressure), in critically intubated children. this study aims to determine the effectiveness of the electronic device in the continuous monitoring of tracheal cuff pressure.

Eligibility criteria:
inclusion criteria: * infants and children more than 2 days after birth at term and less than 5 years of age * patient intubated in the picu with a cuffed endotracheal tube * predicted duration of mechanical ventilation \> or = 24-hours * signed informed consent exclusion criteria: * intubated with an uncuffed endotracheal tube * children admitted to the picu with a previous tracheostomy * preterm children or infants less than 2 days post-term * patient under block neuromuscular treatment * patient enrolled in another trial that might influence this study results

Keywords: tracheal cuff pressure pediatric critical care
postural control among children with and without dyslexia

Conditions: Child Development Disorder

Summary: as chinese-speaking children with dyslexia typically have different cerebellar sign behavior from non-chinese-speaking counterparts, this study compared the effect of visual occlusion on the static balance between dyslexic and non-dyslexic children using the chinese language.


Eligibility criteria:
inclusion criteria: * 1.normal iq(\>85, wisc-iii) * 2.children with dyslexia assessed by standard tools, performed by psychological-teachers of special education exclusion criteria: * 1.attention deficit hyperactivity disorder(adhd) * 2.neurological or psychiatric abnormalities * 3.developmental coordination disorder(dcd)

Keywords: child with dyslexia, postural sway visual perception
depression agency-based collaboration

Conditions: Major Depression; Anxiety Disorder

Summary: seniors who receive supportive services face a variety of psychosocial vulnerabilities that put them at risk for depression. one group with very high risk is older adults receiving aging services through medicaid waiver programs. this 3-year research uses a randomized controlled clinical trial to assess the effectiveness of brief behavioral therapies (problem solving therapy \[pst\] and brief behavioral therapy for insomnia \[bbti\]) to prevent depression in seniors receiving aging services.

the research will determine (i) if a course of problem solving therapy (pst) and brief behavioral therapy for insomnia (bbti), with boosters, reduces incidence of major depressive episodes over 12 months relative to usual care, and (ii) the extent to which behavioral therapies achieve these effects through enhancement of protective factors, such as greater self-efficacy, better targeting of services to address needs, and greater control over home environments. periodic blood draws will be used to assess biosignatures of depression. guiding our investigations of pharmacogenetics, inflammation, and proteomics are synergistic interactions among the serotonergic system, the hpa axis, systemic inflammation, growth factors such as brain derived neuro-trophic factor (bdnf), psychosocial stressors, and vascular co-morbidity. genetic variation in vasopressin receptors, potentially involved in both cardiovascular risk and social attachment, is also associated with recurrence of depression. similarly, genetic variation in inflammation may influence antidepressant response and medical co-morbidity.

Eligibility criteria:
inclusion criteria: * age =\> 60 years * modified mini mental state (3ms) examination =\>80 * receiving aging services or difficulty with 1+ adl/iadl * phq-9 score \> 0 and \ 0) exclusion criteria: * major depressive episode or anxiety disorder within 12 mo * ever diagnosed with bipolar disorder or schizophrenia * drug or alcohol use disorder within the past 12 months * currently taking antidepressants * currently taking antianxiety med \>4x/week for past 4 weeks

Keywords: depression anxiety geriatric mental health
the role of cycling-cognitive dual-task training in early parkinson's disease

Conditions: Safety and Effectiveness

Summary: the purpose of the study will investigate the safety and effectiveness with eight-week cycling-cognitive dual-task training for early parkinson's disease.

background: parkinson's disease is a neurodegenerative disorder of the basal ganglia in which the production of dopamine is reduced, leading to the motor and non-motor impairment and the loss of automaticity. recently, the results across studies have indicated that motor-cognitive dual-task deficits in individuals with neurologic disorders appear to be amenable to training. improvement of dual-task ability in individuals with neurologic disorders holds potential for improving gait, balance, and cognition. the most recent european guideline provides a more graded view, stating that in hoehn and yahr stages 2 and 3 dual-task training may be safe and effective. an overview of current ongoing randomized controlled trials focusing on dual-task rehabilitation, gait training or treadmill training was the major motor-task. however, cycling augmented by cognitive training has not been evaluated. in addition, antioxidant capacity is unclear for parkinson's disease patients with long-term, regular cycling training. study purpose: the purpose of the study will investigate the safety and effectiveness with eight-week cycling-cognitive dual-task training for early parkinson's disease. the antioxidant capacity will be assessed as well. methods: parkinson's disease patients will be assigned to cycling training, cycling-cognitive dual task training, and following 8 weeks. all of the subjects will complete 3 assessments at pre-training, post-4 weeks, and post-8 weeks. the outcome measures are clinical severity and disability, performance of gait-cognitive and cycling-cognitive, cognitive-task performance, peripheral-blood oxidative stress, adverse events, etc. significance: in this study, evidence-based practice as the foundation, and perspective to design a safe and effective cycling-cognitive dual-task training for early parkinson's disease. it can be verified in the clinical application of these experiments feasibility (practice-based evidence).

Eligibility criteria:
inclusion criteria: * patients with idiopathic parkinson's disease (ipd) * an age between 45 to 70 years * asymmetrical onset of at least 2 of 3 cardinal sign * modified hoehn and yahr staging from 1 to 2.5 during off state * montreal cognitive assessment score of 26 or greater exclusion criteria: the patients were ineligible if they had * a neurological history other than parkinson's disease * ever undergone neurosurgery for parkinson's disease * had moderate to severe dyskinesia * been unstable with medical or psychiatric co-morbidities, orthopedic conditions restricting exercise * done more than 20 min of aerobic exercise over 3 sessions per week on their own
pericapsular nerve block versus propofol during hip fractures surgery

Conditions: Difference in Reduction in Visual Analogue Score at 30 Minutes

Summary: the study will compare the efficacy of pericapsular nerve group block (peng) versus low dose propofol for the achievement of painless sitting position before spinal anesthesia in patients undergoing repair of hip fractures.


Eligibility criteria:
inclusion criteria: * all patients in the age group ranging 40-70, both genders, belonging to physical status american society of anaesthesiologists (asa) i and ii exclusion criteria: * patients with old fractures (more than 7 days), polytrauma, bleeding disorders or coagulopathy, local site infection, difficulty expressing pain scores such as hearing disability, mentally challenged, dementia or psychiatric illness and who refused to take part
development and validation of a new paediatric inflammatory bowel disease nutrition risk score (pibd-nuts)

Conditions: Inflammatory Bowel Diseases (IBD); Crohns Disease; Ulcerative Colitis (UC)

Summary: children with inflammatory bowel disease (ibd) including both crohn's disease (cd) and ulcerative colitis (uc) can be at high risk of developing malnutrition due to the nature of their condition. it is also believed that some children with ibd, in need of nutritional care, are not identified quickly by their healthcare professionals. this may negatively affect their nutrition, disease progression and general well-being. hence, it has been proposed that nutritional screening tools or scores (nsts) should be used to promptly identify children needing further dietetic review and input. although there are a few nsts for generic use in sick children at hospital admission, nsts or scores to use for children with ibd are currently missing. in this study, we would like to test the performance of an existing tool that is routinely used for all sick children at hospital admission (the paediatric yorkhill malnutrition score or pyms)(5) and test whether pyms can detect children with ibd who are at risk of malnutrition. if pyms doesn't work well, we will develop a specific tool for children with ibd (the paediatric ibd nutrition score or pibd-nuts).


Eligibility criteria:
inclusion criteria: * pediatric patients with either crohn's disease or ulcerative colitis between the ages of (4-18 years) exclusion criteria: * pediatric patients with ibdu

Keywords: ulcerative colitis crohns disease
personalized vaccine for patients with recurrent malignant glioma

Conditions: Malignant Glioma; Recurrent Glioma

Summary: a single-arm, single-center, open-labeled study will be conducted with an aim to investigate the feasibility, safety, and efficacy of the personalized vaccine for patients with recurrent malignant glioma.


Eligibility criteria:
inclusion criteria: * age 18-70; * signed inform consent; * patients with recurrent malignant glioma; have received surgery, radiotherapy, chemotherapy; * patients' tumor tissue should have a high mutation load(\>10 tmb); be genetically unstable; at least have 10 neoantigens; * should be able to provide tumor tissue and peripheral blood for sequencing and flow cytometry analysis; * at least three months post last operation; one month after the completion of the last anti-drug therapy or radiotherapy; * have not received any immune therapy; * at least have one measurable lesion; * kps \>60; * estimated survival \> 3 months * patients should have adequate organ and bone marrow function; exclusion criteria: * female patient is breastfeeding or pregnant; * known history of allergy to peptides or other stimulating factors (i.e. gm-csf); * known history of graft-versus-host disease (gvhd); * participation in gene therapy; * other malignancy; * systemic disease: i.e., severe infection; hiv; * other conditions upon investigator's judgement;
effects on cellulite appearance

Conditions: Body Fat Disorder

Summary: evaluate the safety and feasibility effecting the appearance of cellulite on the thigh using coolsculpting.


Eligibility criteria:
inclusion criteria * female subjects \> 22 years of age and \< 65 years of age. * subject has clearly visible cellulite on the intended treatment area (thighs), which in the investigator's opinion, may benefit from the treatment. * subject has not had weight change exceeding 5% in the preceding month. * subject agrees to maintain her weight (i.e., within 5%) by not making any major changes in diet or exercise routine during the course of the study. * subject has read and signed a written informed consent form. exclusion criteria * subject has had a surgical procedure(s) in the area of intended treatment. * subject has had an invasive fat reduction procedure (e.g., liposuction, mesotherapy) in the area of intended treatment. * subject has had a non-invasive fat reduction, body contouring, cellulite reduction and/or skin tightening procedure in the area of intended treatment within the past 4 months. * presence of significant suntan in the thighs. * inability to avoid sun exposure in the thighs. * subject has a history of hernia in or adjacent to the areas to be treated. * subject needs to administer or has a known history of subcutaneous injections into the area of intended treatment (e.g., heparin, insulin) within the past month. * subject has a known history of cryoglobulinemia, cold urticaria, cold agglutinin disease, or paroxysmal cold hemoglobinuria. * subject has a known history of raynaud's disease, or any known condition with a response to cold exposure that limits blood flow to the skin. * subject has a history of bleeding disorder or is taking any medication that in the investigator's opinion may increase the subject's risk of bruising. * subject has known sensitivity or allergy to isopropyl alcohol and propylene glycol. * subject is taking or has taken diet pills or supplements within the past month. * subject has any dermatological conditions, such as moderate to excessive skin laxity, or scars in the location of the treatment sites, that may interfere with the treatment or evaluation (stretch marks is not an exclusion). * subject has an active implanted device such as a pacemaker, defibrillator, implants (e.g. buttock implants), or drug delivery system. * subject is pregnant or intending to become pregnant during the study period (in the next 9 months). * subject is lactating or has been lactating in the past 6 months. * subject is unable or unwilling to comply with the study requirements. * subject is currently enrolled in a clinical study of any other unapproved investigational drug or device. * any other condition or laboratory value that would, in the professional opinion of the investigator, potentially affect the subject's response or the integrity of the data or would pose an unacceptable risk to the subject.
the effect of hyaluronic acid on a prefabricated cad-cam bone blocks for ridge augmentation

Conditions: Atrophy of Edentulous Alveolar Ridge

Summary: each patient will receive 2 prefabricated cad-cam allogeneic bone blocks sterilized with gamma rays with different rehydration methods. side i: prefabricated cad-cam allogeneic bone block sterilized with gamma rays hydrated using hyaluronic acid \* side ii: prefabricated cad-cam allogeneic bone block sterilized with gamma rays hydrated using saline solution both blocks are fixed with osteosynthesis screws, covered with non resorbable membranes\*\* the membranes will be removed after 6 months, dental implants will be placed and core biopsy will be collected from the site of the implant placement for histologic evaluation

10 patients will be included in this study with bilateral atrophic posterior mandible for split mouth research . group i: prefabricated cad-cam allogeneic bone block sterilized with gamma rays hydrated using hyaluronic acid group ii: prefabricated cad-cam allogeneic bone block sterilized with gamma rays hydrated using saline solution under la mucoperiosteal flap will be elevated to expose the atrophic ridge then the prefabricated cad-cam allogenic block either mixed with hyaluronic acid (group i) or saline (group ii) will be fixed in its position with titanium miniscrews , the block was coated with a nonporous d-ptfe membrane then closure of flap with nylon second stage: 6 months later exposure of alveolar ridge core biopsy was taken for histological study then insertion of titanium implants. the aim of the study is to investigate the effect of hyaluronic acid on a prefabricated cad- cam bone blocks for ridge augmentation radiographically and histologically.

Eligibility criteria:
inclusion criteria: * patients between 40 to 65 years old. * posterior atrophic mandibular ridge indicated for horizontal and vertical ridge augmentation for dental implant placement. * good oral hygiene exclusion criteria: * systemic diseases that affect host healing responses. * heavy smoking. * poor oral hygiene. * traumatic occlusion, sever para-functional habits (ex. bruxism, clenching,)

Keywords: cad-cam bone blocks hyaluronic acid histomorphometric analysis