Kornimate/medical-research-clean huggingface dataset:
lower uterine segment thickness and term pain,previous cesarean section

Conditions: Cesarean Section; Dehiscence; Cesarean Section Complications

Summary: the purpose of the researchers; the aim of this study is to evaluate the consistency of niche dimensions measured by ultrasonography with visual measurement of the surgeon during the operation of the patient when presenting with pain in her current pregnancy. if patients who have had previous cesarean section present to the emergency department with pain or nst pain, a panic occurs immediately for operation. purpose of researchers; the aim of this study is to investigate whether a really fine determination of the thickness of the old incision line is associated with full-thickness rupture or incomplete rupture, which appears to be an operation, and if a relationship is found, there is a limit for this thickness.


Eligibility criteria:
inclusion criteria: * patients with a previous cesarean section * those in term gestational week (37-42 weeks) * those who apply to the emergency with pain exclusion criteria: * birden fazla sezaryen geçirilmiş öyküsü olan hastalar * önceden geçirilmiş uterin cerrahisi olan hastalar * miad olmayan gebeler * plesantal yerleşim patolojısı olan gebeler
surveillance for early liver injuries caused by runzao zhiyang capsule.

Conditions: Drug-Induced Liver Injury

Summary: this is a prospective registry study to surveil early liver injuries caused by runzao zhiyang capsule (rzzy capsule) through a non-intervention observational way. and attempt to establish a predictive model to screen susceptibilities to rzzy capsule.

the primary objectives of this study include: (i) the detection of patients with serum liver biochemistry abnormalities less than 8 weeks after intake of rzzy capsule; (ii) the record of overall individuals with demographics, underlying diseases, physical status, medication information, clinical laboratory index, and so on; (iii) the specimen collection of surveiled individuals. (iv) the attempt to establish a predictive model to screen susceptibilities to rzzy capsule.

Eligibility criteria:
inclusion criteria: 1. individuals in accordance with indications for rzzy capsule, including skin pruritus, acne vulgaris and constipation; 2. the age range of 18 to 70 years； 3. individuals taking rzzy capsule over 2 weeks; 4. abnormalities of serum biochemistry achieving one of the criteria as follows: (i) alanine aminotransaminase (alt) or aspartate transaminase (ast) ≥2 folds of upper limit of normal (uln); (ii) total bilirubin (tbil) ≥ 2 uln; (iii) alkaline phosphatase (alp) ≥ 2 uln; 5. individuals can provide informed consent form. exclusion criteria: 1. individuals without indications for rzzy capsule; 2. unconformity with the rzzy capsule drug label; 3. individual taking rzzy capsule less than 2 weeks; 4. individuals taking other hepatotoxic drugs combined with rzzy capsule, simultaneously; 5. unconformity with the diagnostic standard for herb-induced liver injury (the guideline for diagnosis and treatment of herb-induced liver injury, rpgip-2016cn003）.

Keywords: drug-induced liver injury
transcatheter intravascular ultrasound energy delivery for renal denervation (achieve)

Conditions: Resistant Hypertension

Summary: the achieve study is a single-arm, open-label, prospective, post-market follow-up study to include up to one hundred (100) eligible patients as defined within the clinical investigational plan, with a twelve month follow-up period. the achieve study was originally designed in accordance with the 2007 esh esc guidelines for resistant hypertension.


Eligibility criteria:
inclusion criteria: * resistant hypertension, as defined in the 2007 esh-esc guidelines * 18 years of age or older * negative pregnancy test for female patients of childbearing potential * willing and able to comply with follow-up requirements * signed informed consent exclusion criteria: * secondary hypertension * main renal arteries length \< 20 mm * main renal arteries diameter \< 4 mm * renal artery stenosis * iliac/femoral artery stenosis precluding insertion of the catheter * untreated allergy to contrast media * currently participating in the study of an investigational drug or device * moderate to severe renal insufficiency

Keywords: hypertension blood pressure renal denervation
what are we missing? diagnosing uterine adenomyosis using ultrasound elastography

Conditions: Uterine Bleeding; Uterine Fibroids; Adenomyosis

Summary: to improve the clinical care of women with pelvic pain and abnormal uterine bleeding due to benign uterine conditions including leiomyomas (uterine fibroids) and adenomyosis by evaluating the accuracy of radiology diagnostic exams (mri(magnetic resonance imaging), ultrasound and ultrasound with elastography).

currently benign conditions of the uterus are frequently underdiagnosed or misdiagnosed. this project will help determine which diagnostic radiology exams are most helpful to the clinician in providing accurate diagnosis. in addition, this study will evaluate which exam (mri vs. ultrasound) patients prefer over another exam.

Eligibility criteria:
inclusion criteria: 1. 18 years of age or older 2. pelvic pain and/or abnormal uterine bleeding. (this is specific for arm. 1 of this study) 3. if you have had or are scheduled to have both a pelvic mri (magnetic resonance imaging) and a pelvic ultrasound with 6 months of the time of enrollment. (this is specific to arm 2 of this study). - exclusion criteria: 1. if you are post-menopausal(have not had a period in at least one year's time). 2. if you have been diagnosed with gynecological malignancy such as uterine, endometrial, cervical or ovarian cancer. 3. if you are unable or unwilling to sign the informed consents 4. if you are unable to undergo the research study exams -
safety of skin cleansing with chlorhexidine in preterm low birth weight infants

Conditions: Neonatal Sepsis; Low Birth Weight

Summary: the purpose of this study is to examine if single skin cleansing with 0.25% chlorhexidine affects skin condition, temperature, and bacterial colonization in stable preterm (28-36 weeks gestational age) low birth weight (1001-2000 g) infants admitted in a health facility.

infections are the leading cause of death in neonates admitted to hospital - studies from developing countries suggest that about 25-71% of deaths occurring in neonatal intensive care units are secondary to infections.such high infection-related mortality mandates an urgent implementation of simple and effective measures to prevent the occurrence of infections in these units. the majority of neonatal infections occur in the first two weeks of life, when the epidermal barrier is immature and functionally compromised. topical application of antiseptics until the skin matures could theoretically prevent skin colonization and reduce the incidence of systemic infections in neonates. chlorhexidine, a broad-spectrum antiseptic used frequently for umbilical cord care in neonates, is now being evaluated for topical application to the skin. hospital-based studies, involving predominantly term infants, have shown reductions in skin flora8 and a reduction in the incidence of sepsis following topical chlorhexidine application. in a community-based study in nepal, a single skin cleansing with 0.25% chlorhexidine resulted in reduction in mortality among low birth weight infants; though the mechanism of the impact could not be determined, it was presumably due to increased susceptibility to transcutaneous sepsis in the low birth weight group. since the risk of infection in neonates is inversely related to their gestation, it is essential to evaluate the effect and the mechanism of such intervention in preterm neonates. these infants are, however, more prone to develop skin reactions following use of topical antiseptics. preterm infants are also more prone to develop hypothermia following bathing/cleansing with antiseptic solution(s). since few studies have evaluated the effects of topical application of chlorhexidine in preterm infants admitted in a health care facility, we conducted the present study to examine if single skin cleansing with 0.25% chlorhexidine immediately after birth affects skin condition, temperature, and colonization in hospitalized preterm low birth weight infants.

Eligibility criteria:
inclusion criteria: * preterm infants of 28 to 36 weeks' gestation * birth weights between 1001 and 2000 g exclusion criteria: * infants with one minute apgar score \< 4 * hemodynamic instability * congenital malformations * generalized skin disorder and * infants who need respiratory support (continuous positive airway pressure and/or intermittent mandatory ventilation) in the first 2-3 hours of life

Keywords: chlorhexidine preterm newborn skin condition temperature skin flora
understanding the impact of physical activity calorie equivalent (pace) labelling in secondary schools

Conditions: Eating Behaviour of Discretionary Foods

Summary: the aim is to undertake a cluster randomised controlled trial to assess the effectiveness of pace food labelling in reducing young people's purchasing of discretionary foods in secondary school canteens. physical activity calorie equivalent (pace) food labelling aims to show the number of minutes or miles/kilometres of physical activity equivalent to the calories contained in food/drinks.

physical activity calorie equivalent (pace) food labelling aims to show the number of minutes or miles/kilometres of physical activity equivalent to the calories contained in food/drinks. evidence suggests that pace food labelling may influence food/drink choice. most research in this area however have tested pace food labels with adults and/or have tested hypothetical food choice scenarios. studies in real world contexts with young people are needed to see if pace food labels could help them make healthier food choices. the aim is to assess the effectiveness of pace food labelling in reducing young people's purchasing of discretionary foods in secondary school canteens. a cluster randomised controlled trial with a nested qualitative study will be conducted. secondary schools will be randomised to either display pace labelling near discretionary foods or continue with their usual practice. the intervention period will be up to 6 weeks. anonymised purchase data will be collected throughout the study period. qualitative interviews will be conducted with students in the intervention schools to explore their views of the pace labels such as perceived influence of the pace labelling on their food selection.

Eligibility criteria:
secondary schools: inclusion criteria: * secondary schools that admit young people aged between 10 to 19 years. * sell at least one type of cake and/or at least one type of sweet biscuit for at least 2 days per week up to a 6 week period (or equivalent), and have sold the same cake(s)/biscuit(s) before the study (for a minimum of 4 weeks). * able to provide to the researcher with anonymised purchase data for study periods. data to include number of units sold and dates sold of the chosen food item(s). * a pace label could feasibly be placed near to the study elected food item(s) in a school canteen used by students. * not participating in any other school trials or initiatives. exclusion criteria: * secondary schools not meeting the inclusion criteria. * secondary schools that admit young people below the age of 10 years or above the age of 19 years.
a study to assess adverse events of fosigotifator (abbv-cls-7262) in adults with major depressive disorder

Conditions: Major Depressive Disorder (MDD)

Summary: major depressive disorder (mdd; depression) is a mood disorder that causes a continued feeling of sadness and loss of interest. it is a common and serious illness that can cause both emotional and physical symptoms such as feelings of sadness, irritability, not being able to focus on activities, tiredness, changes in eating habits, and aches and pains. the main goal of the study is to evaluate how safe and effective fosigotifator is in treating mdd. fosigotifator (abbv-cls-7262) is a new treatment being developed for adult patients with depression. this study is double-blinded, which means that neither the patients nor the study doctors know who is given fosigotifator and who is given placebo. participants will be randomly assigned to one of the two groups to receive fosigatofator or placebo. there is 1 in 2 chance that participants will receive placebo. approximately 106 adult participants with mdd will be enrolled in approximately 15 sites across the world. participants will receive oral fosigotifator or matching placebo. duration of the study is approximately 144 days. there may be higher treatment burden for participants in this trial compared to their standard of care. participants will attend regular weekly visits during the study at a hospital or clinic. the effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.


Eligibility criteria:
inclusion criteria: * body mass index of 18 to 33 kg/m2 at the time of consent. * meet the diagnostic and statistical manual of mental disorders (dsm-5-tr) criteria for mdd based on the structured clinical interview for dsm-5. * current major depressive episode of at least 6 weeks to less than 24 months in duration at screening (visit 1 ). * meets the following disease activity criteria mentioned in the protocol. * requires antidepressant therapy (adt) per the investigator's opinion or, if currently taking adt, must be able to safely discontinue adt at least 7 days prior to the first dose of study drug at baseline (visit 2). exclusion criteria: - primary psychiatric illness other than mdd.

Keywords: major depressive disorder (mdd) fosigotifator abbv-cls-7262
nutritional support on outcomes and cost-effectiveness for patients at risk

Conditions: Malnutrition

Summary: the impact of nutritional support for the patients at nutritional risk on clinical outcomes and cost-effectiveness.

although it was often to hear that malnutrition ratio in aisa hospitalized patient was 40%-70% , there was no evidence to elaborate the prevalence of nutritional risk and malnutrition on hospitalized patients of asia. also in usa no data for nutritional risk. in 2002, scientists group headed by kondrup from : european society for parenteral and enteral nutrition demonstrated that randomized controlled clinical trials showed patients may get benefit from nutrition support when they with nutrition risk. based on these evidences, a simpler method was established by european society for parenteral and enteral nutrition in year 2002 in munich \& it was demonstrated useful to evaluate the appropriate use of nutrition support at present time. this method was named as nutrition risk screening (nrs). investigators propose to survey the prevalence of malnutrition \& nutrition risk in large cities' large/middle size hospitalized patients in china, europe and usa use nrs tool. as well, we also aim to figure out the current nutrition support status in current large/middle size hospitals through this survey. investigators also propose to evaluate the cost-effectiveness of parenteral nutrition, enteral nutrition and non-nutritional support, and to examine the clinical outcomes of nutritional support in certain patients at nutritional risk identified by nrs-2002. for international cooperation, the partners are professor kondrup of europe and professor nolan from johns hopkins hospital,there are students from a cooperative project with johns hopkins hospital for doctor of philosophy students 2005-2011.

Eligibility criteria:
inclusion criteria: * patients be in hospital overnight * diagnoses according to the protocol of cohort study for cost effectiveness exclusion criteria: * patients admitting from emergency department * patients who undergone operation before second morning of hospitalization * patients who dose not give informed consents
comparative study of smile, icl, and wavelight plus alcon technologies in myopia correction

Conditions: Myopia

Summary: myopia is a prevalent refractive error with significant lifestyle impact. while traditional smile (small incision lenticule extraction) and icl (implantable collamer lens) surgeries are standard options, the advent of the wavelight plus alcon system presents a promising new technique. this trial aims to evaluate the safety, efficacy, and patient satisfaction across these methods.


Eligibility criteria:
inclusion criteria: * adults aged 18-40 years * spherical equivalent of -1.00 to -10.00 d * stable refraction for at least 12 months * informed consent provided exclusion criteria: * other ocular pathologies * previous refractive surgery * pregnancy or nursing * autoimmune or connective tissue disorders

Keywords: myopia small incision lenticule extraction implantable collamer lens wavelight plus alcon system vision
fto gene variants and diet in obesity

Conditions: Obesity; Diet Habit; Genetic Predisposition

Summary: studies have shown that the effect of fat mass and obesity-associated (fto) gene on obesity is modulated by lifestyle factors. hence, we aimed to determine whether two single nucleotide polymorphisms (snps) in the fto gene are associated with obesity and to assess whether these associations were modified by lifestyle factors. the study included 200 obese and 200 non-obese individuals from turkey. our study suggests that the effect of the snps on obesity traits is likely to be influenced by lifestyle factors in this turkish population.


Eligibility criteria:
inclusion criteria: 1. attending routine outpatient visits, 2. aged 24 to 50 years, 3. having a bmi ≥ 18.50 kg/m2

Keywords: obesity gene-diet interaction fto gene variant
artificial intelligence-based model for the prediction of occult lymph node metastasis and improvement of clinical decision-making in non-small cell lung cancer

Conditions: NSCLC (Non-small Cell Lung Cancer); Artificial Intelligence (AI); Lymphnode Metastasis

Summary: this nationwide, multicenter observational study aims to develop and validate a multimodal artificial intelligence (ai) model for detecting occult lymph node metastasis in early-stage non-small cell lung cancer (nsclc) patients. despite advances in lymph node staging, 12.9%-39.3% of occult nodal metastasis cases remain undetected preoperatively, affecting treatment decisions. this study will use deep learning to extract imaging features of occult metastasis and combine them with clinical data to build an ai model for risk prediction. this study will provide insights into the feasibility of ai-driven detection of occult metastasis, supporting clinical decision-making and potentially revealing underlying biological mechanisms of lymph node metastasis in nsclc.


Eligibility criteria:
inclusion criteria: * pathologically confirmed non-small cell lung cancer; * clinical stage i (ajcc, 8th edition, 2017); * age≥18 years old; * kps score≥70; * patients who have undergone primary nsclc radical surgery or sbrt treatment; * complete systemic lesion imaging assessment before primary nsclc radical surgery or sbrt treatment (note: tumor size ≥ 3 cm or centrally located tumor requires pet/ct and/or invasive mediastinal staging); * patients willing to cooperate with the follow-up after primary nsclc radical surgery; * informed consent of the patient. exclusion criteria: * poor quality of computed tomography imaging; * baseline imaging shows pure ground-glass nodules (ggo); * uncontrolled epilepsy, central nervous system disease, or history of mental disorders, judged by the researcher to potentially interfere with the signing of the informed consent form or affect patient compliance.; * loss to follow-up.
pre- and post-operative exercise program in upper gastrointestinal cancers

Conditions: Exercise Intervention

Summary: esophageal and gastric cancers are a considerable health burden. in the past 10 years the 5-year survival for both cancers has doubled. this is due to a number of factors including advances in neo adjuvant and adjuvant chemotherapy and radiotherapy. however, physical fitness significantly declines as a result of neo adjuvant an adjuvant therapy. from studies in other cancers it is known that peri operative training improves physical fitness, yet there is little research into its effects in those with upper gastrointestinal cancers. the aim of this study is to assess the effect of a pre-and post operative training program on patients with upper gastrointestinal cancers on their physical fitness and consequently their optimism, quality of life and post operative morbidity.

the comparator in this study will be standard oncological care. there patients will receive the exact same care as the intervention group patients but will receive no exercise training program. the primary goal of this multi-centre randomised controlled trial are to investigate the effects of peri-operative exercise training programmes on physical fitness, measured with a 6 minute walk test, in patients undergoing a major curative upper-gi resection for either oesophageal or gastric cancer. the secondary aims will look at the effect of peri-operative exercise training on patients quality of life, optimism and well being, post operative morbidity, nutritional status and blood markers of inflammation.

Eligibility criteria:
inclusion criteria: * be 18 years of age or above; * have confirmed multi disciplinary team (mdt) evidence of adenocarcinoma or squamous cell cancer of the oesophagus, oesophago- gastric junction or stomach requiring neoadjuvant therapy and planned curative resection. * be referred by a multidisciplinary team meeting for neo adjuvant chemotherapy or neo adjuvant chemoradiotherapy prior to planned oesophagectomy or gastrectomy. * have measurement confirming (endoscopic or otherwise) that the tumour starts more than 5cm below cricopharyngeus; * be fit for pre-operative anaesthesia and surgery * be able to provide written informed consent. exclusion criteria: * inability to participate in the exercise program (unable to perform 6 minute walk test, unable to attend for assessment of parameters at any time point). * patients with high grade dysplasia (squamous cell or adenocarcinoma); * patients who have or develop metastatic disease at time of enrolment or during their neoadjuvant therapy; * patients being referred for primary surgery without requirement for neoadjuvant treatment; * patients with squamous cell cancer of the oesophagus who the mdt recommends or who individually elect to undergo definitive chemoradiotherapy; * evidence of previous/concomitant malignancy that would interfere with this treatment protocol; * pregnancy; * patients participating in other trials that would interfere with the implementation of this protocol at a particular site.

Keywords: oesophageal cancer gastric cancer physical fitness