Kornimate/medical-research-clean huggingface dataset:
the diagnosis and prognosis of nonpalpable breast cancer detected by the us vs mammography: a clinical noninferiority trial.

Conditions: Breast Cancer

Summary: to evaluate and compare the sensitivity, specificity, auc, pathology results of core needle biopsy and surgical pathology results coincidence rate, tumor staging, and dfs (disease-free survival) of us-detected nonpalpable breast cancer vs mammography-detected nonpalpable breast cancer.


Eligibility criteria:
inclusion criteria: 1. women aged 18 years and over with full capacity for civil conduct; 2. breast imaging examination (including mammography and breast ultrasound) found that patients with bi-rads 4 or nonpalpable lesion need to have breast biopsy (refer to the classification of bi-rads, which is consistent with the indications for biopsy), including some patients with bi-rads 3 nonpalpable breast lesions who are willing to have biopsy; 3. voluntarily participate in and sign the informed consent form, and be willing to accept the inspection designated by this test; 4. the results of blood examination, coagulation examination, preoperative infection examination, and 12 lead ecg examination within 2 weeks before biopsy met the biopsy requirements; 5. it conforms to the biopsy standard (refer to the image-guided breast histology biopsy guide in the breast cancer diagnosis and treatment guide and specification of china anti cancer association (2019 version)). exclusion criteria: 1. women are participating in another clinical trial of drug or medical device; 2. women with neuropsychiatric disorders; 3. women with severe systemic diseases and serious bleeding diseases that can not cooperate with the examination, or the researchers think it is not suitable to participate in this clinical trial; 4. other subjects not suitable for x-ray examination
formative phase of reducing hazardous alcohol use & hiv viral load

Conditions: Alcohol Drinking; Alcohol Use Norms; Alcohol Use Among ART Clients

Summary: this study is the formative phase of a larger study; once this phase is completed, enrollment into the randomized controlled trial (rct phase) will begin. the primary objective of the formative phase is to gain a better understanding of the context in which drinking alcohol among art client in vietnam occurs, in order to culturally tailor the intervention to be tested in the rct phase. formative phase activities will consist of up to 40 in-depth interviews with hazardous drinkers who are either: a) art clients in one of the art clinics in thai nguyen, or b) who are people who inject drugs (pwid) that are not recruited from the art clinics (whom we will refer to as general population pwid).


Eligibility criteria:
inclusion criteria: * being 18-49 years of age; * having an audit score ≥ 8 (hazardous alcohol use); * being a current art client at one of the thai nguyen art clinics or a general population pwid; * being capable of providing voluntary informed consent. exclusion criteria: * being unable to participate in study activities due to psychological disturbance, cognitive impairment or threatening behavior; * currently participating in other hiv, drug use or alcohol studies.
clinical efficacy of ginkgo biloba extract in the treatment of alzheimer's disease

Conditions: Alzheimer's

Summary: this project explores ginkgo biloba ester dispersible tablets influence on cognitive function in patients with mild-to-moderate elderly, to observe the effects of different intervention time on cognitive function, for alzheimer's patients in drug rehabilitation treatment provides an effective solution.

the assessment of cognitive scales included minimum mental state examination(mmse), alzheimer's disease assessment scale-cognition(adas-cog), neuropsychiatric inventory(npi), quality of life of life in alzheimer's disease(qol-adl), activities of daily living(adl), geriatric depression scale(gds).biochemical test included cholesterol, triglycerides, and low density lipoprotein.

Eligibility criteria:
inclusion criteria: 1. all patients were diagnosed with dementia caused by ad in 2011, the latest diagnostic criteria for alzheimer's disease (nia-aa), according to the patient's clinical and cranial imaging findings 2. improved hachinski ischemic scale score \<4 3. all patients underwent head ct and / or mri examinations and laboratory tests to rule out other causes of dementia 4. mmse(high school≤24,primary school≤20;illiteracy≤17) 5. cdr 1-2 6. the subjects and nurses signed informed consent, and the nursing staff were able to take responsibility for the supervision of the participants 7. the subjects were stable 8. cooperate, willing to complete all parts of the research, and have the ability to complete the study alone or with the help of the nursing staff 9. to cooperate with the study, do not live alone, such as living alone should keep in touch with the nurse every day. exclusion criteria: 1. heart lung kidney disease, may interfere to evaluate the efficacy and safety of patients at risk or special disease,for example:congestive heart failure et al. 2. according to ninds-airen standard (roman gc et al 1993) is currently diagnosed as possible vascular dementia 3. improved hachinski ischemic scale score（mhis）≥4 4. diagnosis of severe depression, schizophrenia, and other major neurodegenerative disorders, according to the dsm-iv axis 5. neurological or other medical disorders that affect the function of the central nervous system,like moderate anemia,vitamin b12 or folic acid deficiency, et al. not with the cognitive function examination (including blindness, deafness, severe language disorders).

Keywords: ginkgo biloba dispersible tablets alzheimer's
glycemic response to three oral nutrition supplements in persons with type 2 diabetes mellitus

Conditions: Diabetes

Summary: this will be a randomized, cross-over design. subjects will be randomized to one of three interventions on three separate study days, 1 week apart.

following consent, subjects will be randomized to one of three arms. after an overnight fast an intravenous line will be placed for blood withdrawal. the subject will then consume the randomly assigned intervention. blood samples for glucose and insulin levels will be drawn at specified intervals after the product has been consumed.

Eligibility criteria:
inclusion criteria: * age 20-75 yrs * type 2 diabetes controlled with diet or diet and oral agent, with the exception of sulfonylureas such as glimepiride (amaryl), glipizide (glucotrol/glucotrol xl) and glyburide (diabeta, micronase, (glynase prestabs); meglitinides such as reaglinide (prandin) and nateglinide (starlix); and alphaglucosidase inhibitors such as acarbose (precose) and miglitol (glyset) * hemoglobin a1c less than 9.0% * fasting blood glucose less than 180 mg exclusion criteria: * abnormal thyroid function * creatinine \>2.0 mg/dl * potassium \<3.5 meq/l * gastrointestinal disease: ulcer, gastritis, diarrhea, gastroparesis, vomiting * currently unstable diabetes or under treatment for cancer, heart disease, renal disease * unable to give informed consent or follow instructions * current insulin therapy or insulin therapy within the past month * patients who are pregnant * allergies to milk, soy or any component of the test product * patient who in the investigators assessment cannot be expected to comply with treatment * currently participating or having participated in another clinical trial.
basket trial of idx-1197, a parp inhibitor, in patients with hrr mutated solid tumors (vastus)

Conditions: Solid Tumors; Homologous Recombination Repair Gene Mutation; Homologous Recombination Deficiency

Summary: this study is a phase 1b/2a basket trial to assess safety and efficacy of idx-1197 in patients with hrr mutation. there are two parts to this study: phase 1b, idx-1197 dose-selection study to determine rp2d and phase 2a, non-randomized parallel dose expansion study to confirm rp2d.


Eligibility criteria:
inclusion criteria: * histologically confirmed cancers that have hrr mutation and are failed to standard therapy or for which standard or curative therapy does not exist or is not considered appropriate by the investigator. * measurable disease according to recist, v1.1. * eastern cooperative oncology group (ecog) performance status (ps) of 0-2 * must have recovered from all side effects of their most recent systemic or local treatment (\&lt;ctcae grade 3) * life expectancy greater than 12weeks exclusion criteria: * prior treatment with parp inhibitors * symptomatic cns metastases * history of or known carcinomatous meningitis * concurrent administration of any anti-cancer therapies other than those administered in this study * pregnant or lactating women * refractory nausea and vomiting, malabsorption, total gastrectomy, external biliary shunt or significant bowel resection that would preclude adequate absorption. * uncontrolled medical illness (such as infection requiring treatment with intravenous antibiotics) * severe or unstable angina, myocardial infarction or ischemia requiring coronary artery bypass graft or stent within the previous 6 months, symptomatic congestive heart failure, arterial or venous thromboembolic events (e.g., pulmonary embolism, cerebrovascular accident including transient ischemic attacks), or clinically significant ventricular arrhythmias within 6 months prior to enrollment or new york heart association (nyha) class ii to iv heart disease. * immunocompromised patients, e.g., patients who are known to be serologically positive for human immunodeficiency virus (hiv) * known hypersensitivity to idx-1197 or any of the excipients of the product

Keywords: hrr 1197 venadaparib idx-1197
the effects of exercise on emotion regulation and cognitive control in ptsd

Conditions: Emotion Regulation; Cognitive Control; PTSD

Summary: the goal of this study is to investigate the effects of a single bout of aerobic exercise on neurophysiological indices of emotion regulation and cognitive control in individuals with clinically significant ptsd symptoms. in this proposed study, 50 adult females with clinically significant ptsd symptoms will be randomized into two groups: a 20-minute moderate-to-vigorous intensity aerobic exercise group, or a 20-minute silent sitting control group. prior to and following the exercise/sitting session, participants will complete a letter flanker task and an emotion regulation picture viewing task while their electrical brain activity is continuously recorded via electroencephalogram (eeg). utilizing a multimodal assessment approach, cognitive control will be measured using behavioral (i.e., accuracy, reaction time) and neurophysiology (i.e., error-related negativity; ern). emotion regulation will be measured using self-reported and neurophysiological indices of emotional reactivity (i.e., late positive potential; lpp).


Eligibility criteria:
inclusion criteria: * female adults who are currently experiencing clinically significant ptsd symptoms. participants will be screened via qualtrics using the posttraumatic stress disorder checklist for the dsm-5 (pcl-5; weathers et al., 2013). the pcl-5 is a 20-item self-administered questionnaire designed to screen for ptsd. the pcl-5 asks about the frequency of ptsd symptoms experienced in the past month using a 5-point likert scale. participants with a total score \> 30 on the pcl-5 will be eligible to participate. exclusion criteria: * using the physical activity readiness questionnaire (par-q; adams, 1999), participants will be excluded if they endorse any history of cardiovascular (e.g., coronary artery disease, heart failure, high blood pressure) or metabolic disease (e.g., diabetes), or any orthopedic limitations (e.g., osteoporosis) that may interfere with participating in aerobic exercise. * additionally, participants must not have a history of head trauma resulting in loss of consciousness for more than 5 min, epilepsy, or hearing, visual, or other physical or mental impairments that could interfere with the collection of quality neurocognitive data.

Keywords: emotion regulation cognitive control ptsd exercise
my diabetes care mobile: a usability study

Conditions: Diabetes Mellitus, Type 2

Summary: the purpose of this study is to conduct a prospective, longitudinal study on the my diabetes care mobile (mdc-m) intervention to assess usage patterns, user experience, and to uncover errors in functionality prior to a larger interventional trial.

up to 65 adult patients with type 2 diabetes mellitus will be enrolled and given access to my diabetes care mobile (mdc-m). my diabetes care mobile (mdc-m) is a multi-faceted patient portal intervention for mobile devices that is designed to help patients better understand their diabetes health data as well as promote and support self-management. mdc uses infographics to facilitate patients' understanding of their diabetes health data (e.g., hba1c, ldl), incorporates motivational strategies and access to an online patient support community, and provides literacy level-appropriate and tailored diabetes self-care information. patients will be invited by mail to be screened for enrollment in the study. interested patients will be able to complete an electronic consent form and enroll online via research electronic data capture (redcap™) version 5.0.8. study participants will complete questionnaires electronically via email using redcap™ at two time points: baseline (t0) and one-month follow-up (t1). participants will complete an baseline questionnaire (t0) including basic demographic questions, items about computer usage and internet access, and validated measures of health literacy and ehealth literacy. each participant will have access to the mdc-m for 1 month.

Eligibility criteria:
inclusion criteria: * type 2 diabetes mellitus * currently taking at least one medication for diabetes * age 21 or over * able to speak and read in english * reliable access to a smartphone or tablet with internet access * active vumc patient web portal (known as my health at vanderbilt) account exclusion criteria: * residing in a long term care facility * medical condition that affects my memory or ability to think. * severe visual impairment * patients with unintelligible speech (e.g., dysarthria) * currently participating in another diabetes-related research study

Keywords: diabetes mellitus self-efficacy patient web portals
cerebral bases bodily representations

Conditions: Glial Tumors

Summary: bring elements of understanding to the study of brain organization bodily representations. the body is organized into multiple, distinct levels of representation. the body schema is an unconscious and dynamic representation of his body, updated constantly, resulting from the convergence of multiple sensory information, which articulates with the motor systems to participate in the genesis of the action. the self-image corresponds to a more abstract representation of the body, covering symbolic and imaginary aspects drawn from the emotional life of the individual. finally, the body of another person engages simultaneously shared and differential representational systems that allow understanding the actions of others while preserving the identity of the agent responsible for the action. these various bodies represented subtly interacting and participating in equilibrium, the self-awareness building as being curious, social and acting. brain organization bodily representations remains a fundamental question still poorly explored that is of major scientific interest because of its influence on identity and social construction, and the serious repercussions that are their problems, also for the individual and society. this project aims to deepen this hypothesis using a methodology combining functional imaging and awake surgery. the richness of this project lies in the innovative methods of investigation, and in the plurality of disciplines (neuropsychology, neurophysiology, neuroimaging and neurosurgery) and teams (clinical and research) grouped for wear. the subjects enrolled in this study are all candidates in patients with awakened provided surgery for therapeutic reasons, and volunteer to participate in this experiment. awake neurosurgery is for patients with glial tumors, but also brain metastases and intra-parenchymal cavernomas. a first experimental session will be held in pre-operative period. patients realize a functional magnetic resonance imaging (fmri) brain to define a precise functional mapping of cortical structures, including lateral occipital, involved in body representation. the second experimental session will be conducted in the neurosurgical intervention, practiced one to four weeks later. this dual approach that combines the functional stimulation of a cortical area (imaging) and functional inhibition (in surgery) allows you to make extremely robust scientific arguments about the causal relationships linking structure and function


Eligibility criteria:
inclusion criteria: * age greater than 18 years * candidate awake in a long surgery * carrying on an original tumor glial parietal or temporal * normal global cognitive efficiency score greater than or equal to 27 exclusion criteria: * patient ambidextrous or left * non glial tumor * tumor not involving the temporal or parietal lobes * consumption of non-drug substance * visual perceptual disorder and or space * global cognitive impairment
antipsychotic to treat psychosis syndrome

Conditions: Psychotic Disorders

Summary: this study assess the safety and effects of atypical antipsychotics in subjects with psychosis syndrome and psychosis risk syndrome.

the investigators investigated whether administration of atypical antipsychotics could alleviate prodromal symptoms and be well tolerated by subjects with psychosis syndrome and psychosis risk syndrome.

Eligibility criteria:
inclusion criteria: * were help-seeking young individuals in outpatients service * aged 16-30 years * fitted one of the following criteria: psychosis-risk syndromes (cops-sips) or psychotic syndrome (pops-sips) or dsm-iv diagnosis of schizophreniform disorder exclusion criteria: * a previous diagnosis of any psychotic disorder or bipolar disorders according to the diagnostic and statistical manual of mental disorders, fourth edition; * symptoms fully accounted for by an axis 1 disorder or sequelae of drug/alcohol use; * neurological disorders or organic disorders affecting the central nervous system, substance-related disorders or mental retardation as defined by the dsm-iv criteria; * history treatment of antipsychotic or antidepression, mood stabilizers or electroconvulsive therapy; * diagnosed as having a serious and unstable medical condition.

Keywords: psychosis syndrome risk antipsychotic
a multidrug-resistant (mdr) and extensively drug- resistant (xdr) tuberculosis study in alsace

Conditions: Tuberculosis

Summary: the purpose of this study is to examine the epidemiology of tb mr in strasbourg and evaluate the second-line anti-tuberculosis treatments effectiveness, and the relevance and adequacy of the treatments with who recommendations. during years 2006-2016, all new cases of mdr tb or xdr tb diagnosed strasbourg university hospital will be included in the study (22 cases). data were collected from the center for tuberculosis control (clat) records, the patient's medical records.


Eligibility criteria:
inclusion criteria: * major patient (≥18 years old) * patient hospitalized at strasbourg university hospital from 2006 to 2016, with proven mdr or xdr tuberculosis exclusion criteria: - refusal of the patient to participate in the study

Keywords: tuberculosis multi-drug resistant tuberculosis observational retrospective study clinical epidemiology treatment outcome migrant precarity
facilitated tucking position during endotracheal suctioning

Conditions: Respiratory Distress Syndrome

Summary: aim of the present study the present study will aimed to determine the effect of facilitated tucking position during endotracheal suctioning on physiological criteria and behavioural responses of the preterm neonates. research hypotheses 1. preterm neonates who receive facilitated tucking position during endotracheal suctioning exhibit more stable physiological criteria than those who do not. 2. preterm neonates who receive facilitated tucking position during endotracheal suctioning exhibit more stable behavioral responses than those who do not.


Eligibility criteria:
inclusion criteria: * gestational age between 32 and 36 weeks, weight 1200 grams or greater. * postnatal age: two days after delivery to allow for resolution of analgesia or anesthesia received by their mothers during labor. * have endotracheal intubation. exclusion criteria: * preterm neonates who have congenital anomalies or neurological malformations, intracranial hemorrhage, seizures. * preterm neonates who received sedatives within four hours before the intervention * preterm neonates who exposed to any uncomfortable procedure for at least 30 minutes prior to the intervention.

Keywords: physiological measurement behavioral responses of the preterm neonates facilitated tucking position endotracheal suctioning
the role of emotional processing in improving the quality of life of breast cancer patients

Conditions: Breast Cancer Female; Depressive Symptoms; Fatigue; Pain; Emotions; Inflammation

Summary: the purpose of this study is to examine two mechanistic changes: emotion processing (awareness, expression and acceptance) and cholinergic anti-inflammatory processes (hrv and cytokine expression) through which an art therapy (at) intervention reduces depression, pain and fatigue.

the study is a randomized controlled study with careful controls. our study population is comprised of 240 bc patients in palliative and curative care (comprised of 50% jewish and 50% arab). this population will be randomized to receive a standard art therapy intervention or a comparison group. the at intervention is an 8-week group intervention comprised of 8 1.5 hour weekly sessions conducted by an experienced art therapist the comparison group will engage in the coloring of prefabricated shapes (mandalas) and will receive psychoeducation on topics related to coping with bc, identical to the topics of the at group. this design will allow the study to test the mechanism of at that is beyond the effects of time with a group, focus on a task and engagement with art materials.

Eligibility criteria:
inclusion criteria: * adult (\>18) females with initial or recurrent bc * intervention can begin 3 months after finishing chemotherapy and radiotherapy (rt) and one month after surgery, up until 18 months after treatment completion. * can complete assessments in arabic or hebrew * provides informed consent. exclusion criteria: * male * lifetime history of bipolar disorder, schizophrenia, schizoaffective disorder or with a pre- cancer diagnosis of fibromyalgia or chronic fatigue syndrome * active suicidal plan (will ensure immediate intervention); * dementia/other disorder that would preclude informed consent or comprehension of assessments * individuals taking anticholinergic medications, and post myocardial infarction (6 months before recruitment) or with a pacemaker, which would render the metric of hrv invalid. * flare-up in systemic autoimmune disease (such as arthritis, lupus or multiple sclerosis), thyroid dysfunction that requires increases in medication

Keywords: emotion processing art therapy breast cancer cholinergic anti-inflammatory pathway