Kornimate/medical-research-clean huggingface dataset:
clinical research on the treatment model of ambulatory surgery for colorectal cancer

Conditions: Colorectal Carcinoma; Day Surgery

Summary: to investigate the postoperative complication incidence and long-term efficacy between ambulatory surgery for colorectal cancer and traditional laparoscopic colorectal surgery in patients with colorectal tumor who are generally in good health and have sufficient organ functions。


Eligibility criteria:
inclusion criteria: 1. patients voluntarily joined this study and signed an informed consent form； 2. age: 18-75 years old； 3. the patient should have a good general condition and no serious internal medicine comorbidities (asa classification of the american anesthesiology association is grade i\~iii)； 4. complete colonoscopy and colonoscopy biopsy, and the pathology is confirmed to be adenocarcinoma/high-level intraepithelial neoplasia； 5. enhanced ct or mri examination before surgery, indicating that the tumor diameter is ≤5.0 cm； 6. preoperative staging: ct1-3nanym0; 7. strictly follow the colorectal day surgery plan, and micro-laparoscopic radical colorectal cancer treatment can be adopted； 8. there are no contraindications for abdominal wall nerve block anesthesia or non-opiate analgesic drugs; 9. does not require conventional anticoagulant therapy or antiplatelet therapy； 10. relatives or co-residents should be able to provide 24 hours of full escort within at least 72 hours after the operation, the place of residence is not more than a 30-minute drive from the hospital, and they can understand and follow the phased treatment plan of diet, analgesic drugs, etc. after the operation. exclusion criteria: 1. elderly patients with multiple basic diseases； 2. moderate to severe anemia； 3. severe hypoproteinemia； 4. diabetes that is not well controlled； 5. contraindications to laparoscopic surgery； 6. cases of emergency surgery due to acute intestinal obstruction, perforation or bleeding； 7. patients with distant metastases； 8. patients who are unwilling to sign informed consent or follow-up according to the research plan； 9. people with a history of psychotropic drug abuse and unable to quit or have mental disorders； 10. patients who live alone or in psychosocial isolation, patients who cannot understand the postoperative nursing process； 11. after the operation, the place of residence is far away from the treated hospital or patients with insufficient medical resources and inconvenient transportation； 12. according to the judgment of the researcher, there are concomitant diseases that seriously endanger the safety of the patient or affect the completion of the patient\&#39;s research.

Keywords: colorectal cancer day surgery laparoscope
clozapine-augmentation with ziprasidone or risperidone, a randomized, prospective trial

Conditions: Schizophrenia, Schizoaffective Disorder

Summary: we aim to compare the augmentation of clozapine with ziprasidone or risperidone in a randomized, prospective manner.

partial response of schizophrenic psychoses to a monotherapy with clozapine is a frequent problem of clinical psychiatry. current problems are treatment resistant positive and/or negative symptoms, as well as side effects. therefore, different strategies of augmentations have been applied. based on successful experiences in case reports and results of other work groups, we aim to compare the augmentation of clozapine with ziprasidone or risperidone in a randomized, prospective manner.

Eligibility criteria:
inclusion criteria: * treatment resistant schizophrenic or schizoaffective disorder under therapy with clozapine, * age between 18 and 70, * informed consent exclusion criteria: * no informed consent, * intolerance with respect to ziprasidone or risperidone, * contraindications with respect to these substances, * gravidity or missing anticonceptive safety * substance dependance (excluded nicotin)

Keywords: schizophrenia, schizoaffective disorder, treatment resistancy clozapine, ziprasidone risperidone combination
suvorexant for opioid/stimulant co-use

Conditions: Opioid Use Disorder; Stimulant Use Disorder

Summary: this study will evaluate whether suvorexant 20mg reduces drug use and craving, and improves sleep and stress among persons with co-occurring opioid use disorder and stimulant use disorder.

this between-subjects, double-blinded, randomized controlled pilot study will recruit patients who are receiving methadone or buprenorphine treatment for oud and are using cocaine. participants will be randomly assigned to receive up to 30-days of suvorexant (suvo) or placebo. they will visit the clinic regularly to provide urine drug screens and complete questionnaires and will wear a device that can measure their sleep parameters. we expect that relative to persons who receive placebo, individuals who receive suvo will 1) be less likely to screen positive for cocaine and/or opioids on urine drug screens, 2) will report lower drug craving, 3) will have longer total sleep time, 4) will report fewer insomnia symptoms, and 5) will report overall lower stress than persons who receive placebo. we also expect that patients will not have side effects from suvo. these preliminary data will inform whether this fda-approved medication may help patients stop co-using opioids and stimulants, which can be scaled up to reduce public health consequences related to co-use.

Eligibility criteria:
inclusion criteria: 1. ages 18-65, 2. meet criteria for stimulant use disorder, based on the diagnostic and statistical manual of mental disorders, fifth edition, text revision (dsm-5-tr) 3. currently receiving methadone or buprenorphine treatment for oud and considered to be stable on current dose for at least 30 days 4. willingness to engage with study protocol 5. use of birth control (as appropriate) exclusion criteria: 1. psychiatric or medical conditions that are judged by the investigators to interfere with participation or that are contraindicated for use with suvo 2. pregnant or breastfeeding 3. current use of benzodiazepines, tranquilizers, or other schedule iv sleep medications 4. moderate or severe substance use disorder other than opioid or stimulant use disorder 5. suvo consumption in the last 30 days 6. use of medications that are contraindicated with the study 7. past 30-day suicidal behavior 8. use of continuous positive airway pressure (cpap) device for sleep apnea

Keywords: orexin receptor antagonist suvorexant cocaine opioid opiate heroin fentanyl nonmedical opioid use methadone buprenorphine suboxone polysubstance use co-use substance-related disorders narcotic-related disorders chemically-induced disorders sleep stress opioid-related disorders stimulant-related disorders cocaine use disorder
hydration and outcome in older patients

Conditions: Dehydration

Summary: dehydration is recognised as a major issue in healthcare. recovery after illness, extended length of stay, pressure sores and slow tissue recovery can all be impacted by dehydration. one of the biggest problems for many people with regard to getting a drink is easy, independent access - if they can't reach the jug/cup without a struggle then they often will go thirsty and potentially become dehydrated. the purpose of this study is to investigate the impact of dehydration on outcome in patients 65 years and over. furthermore we aim to assess the impact of providing easy, 24 hour, independently accessible fluids on reducing dehydration as well as improving patient experience. we hypothesise that patients who are dehydration will take longer to recover from illness and stay in hospital for longer periods.


Eligibility criteria:
inclusion criteria: 1. - all patients of 65 years and over that are admitted acutely to medical wards 2. - ward staff who have been working in the clinical area for the duration of the trial (the hydrant part of the study). exclusion criteria: 1. - patients who are moribund 2. - patients who are doubly incontinent 3. - patients on the end of life pathway 4. - patients with terminal illness with a known life expectancy less than 3 months

Keywords: hydration elderly patients age 65 years and over admitted acutely to medical admissions ward
real-world evaluation of the impact of baseline metastases on clinical outcomes among braf positive metastatic melanoma patients

Conditions: BRAF Positive Metastatic Melanoma

Summary: this was a retrospective real-world evidence cohort study.


Eligibility criteria:
inclusion criteria: * diagnosis of melanoma (the international classification of diseases, 9th revision \[icd-9\] 172.x \& 10th revision \[icd-10\] c43 or d03x). * pathologic stage iv at initial diagnosis on or after 01 january 2011. * first-line treatment with io monotherapy or combination therapy (nivolumab, pembrolizumab, ipilimumab + nivolumab) or tt combination therapy (dabrafenib + trametinib, vemurafenib+cobimetinib, encorafenib+binimetinib) on or after 01 january 2014. * evidence of a braf test. * evidence of a braf-positive result prior to or up to 30 days after first-line (1l) therapy initiation. * at least 18 years of age at the time of initiation of 1l treatment. exclusion criteria: * documented receipt of a clinical trial treatment for cancer at any time on or after 01 january 2014. * diagnosis of a second primary cancer or secondary cancer following initiation of 1l metastatic melanoma (mm) treatment.
impact of a parenting program in liberia to improve parenting, education, and health outcomes for children in liberia

Conditions: Parenting Behavior; Pre-academic and Developmental Skills; Malaria Prevention

Summary: the aim of this study is to assess the impact of an intervention to improve parenting practices, pre-academic and developmental skills, and use of mosquito nets for children in kindergarten in liberia. a rigorous impact evaluation using a randomized, waitlist controlled design will be conducted to measure the impact of the intervention on three primary outcomes: positive parenting skills, children's cognitive and educational skills, and malaria knowledge and prevention behaviors.


Eligibility criteria:
inclusion criteria: * parents or primary caregivers (age 18 or above) of children ages 3-7 enrolled in kindergarten * resident in one of five study sites exclusion criteria: * severe cognitive disability of caregiver affecting ability to provide informed consent

Keywords: child parents parenting child development parent child relations malaria primary prevention punishment education
epidemiology of congenital cytomegalovirus in a high hiv prevalence setting, south africa

Conditions: Cytomegalovirus Congenital; Hearing Loss; Neurodevelopmental Disorders; Immunogenicity; Neonatal Death; Stillbirth

Summary: the aim of this project is to determine the epidemiology of congenital cytomegalovirus (cmv) infection and incidence of subsequent permanent neurological sequelae in a high hiv prevalent setting in soweto, johannesburg. a cross-sectional study will be conducted on mother-infant pairs, screening mothers for cmv infection and newborns for congenital cmv infection. maternal cmv prevalence will be determined by testing for cmv specific antibodies in blood. newborn congenital infection will be determined by polymerase chain reaction (pcr) tests on newborn saliva and urine within 3 weeks of birth. various risk factors associated with congenital cmv such as hiv exposure, and gestational age will be assessed. the association between maternal vaginal cmv shedding postnatally with congenital cmv infection will be explored by swabbing maternal vaginal fluid and conducting quantitative cmv pcr analysis. newborns confirmed with congenital cmv and a control group of uninfected newborns will form a cohort to be followed up until 12 months of age monitoring for various neurological sequelae such as hearing loss, neurodevelopmental impairment, ocular damage, cerebral damage and seizures. a comparison of vaccine immune responses between cases of congenital cmv and the cmv uninfected infants to the primary series of vaccines in the national expanded programme on immunisation will be compared. the contribution of cmv infection to neonatal death and stillbirths will be described by minimally invasive tissue sampling (mits) for cmv on babies that die during the neonatal period and stillbirths.


Eligibility criteria:
inclusion criteria: * mother's age ≥18y * residing in soweto and would be available for study follow-up * consents to enrol self and baby in study exclusion criteria: - mother not enrolled in v98_28obtp (nct02215226)
emergency surgery during covid compared to emergency surgery during pre-covid period

Conditions: Emergencies; Surgery; COVID-19

Summary: the aim of this study is to analyze the trend of hospitalizations and how emergency operations have qualitatively and quantitatively changed in our department of medical and surgical sciences of the foggia hospital from 2019 (pre-covid era) to date.


Eligibility criteria:
inclusion criteria: * patients underwent emergency surgery from march 2019 to may 2022 exclusion criteria: * patients underwent elective surgery
genetic analysis of prostate cancer to identify predictive markers of disease relapse or metastatic evolution

Conditions: Prostatic Neoplasms

Summary: developing a genetic study on localized or locally advanced prostate cancer. the aim of the study is to identify genomic alteration predictive of metastatic recurrence in the context of primary heterogeneity, by using the next generation sequencing (ngs) techniques. identifying such biomarkers may be useful to detect a higher relapse risk, and thus lower the mortality rate.


Eligibility criteria:
inclusion criteria: * patients managed by radical prostatectomy for prostate cancer between 2000 and 2016. * follow up \> 6 years * negative pre surgical extension assessment * prognostic grade groups (ogg) iii-iv-v * biochemical recurrence defined by 2 consecutive psa rises ≥ 0,2 ng/ml * metastasis positive imaging exclusion criteria: * neoadjuvant therapy * follow up \< 6 years * prognostic grade groups (pgg) i-ii * biochemical recurrence with metastasis negative imaging

Keywords: localized prostate cancer prostatectomy biomarkers metastatic recurrence genomic
effects of mindfulness meditation on rhinoplasty outcomes

Conditions: Nose Deformity

Summary: a key factor in determining success of facial plastic plastic surgery is overall patient satisfaction. while a number of patient-reported outcomes tools has been developed, there is still limited research in how physicians can improve patient satisfaction and post-operative outcomes. the goal of this study is to investigate the effect of a mindfulness meditation phone application on rhinoplasty outcomes. this study will also explore whether mindfulness meditation is a feasible adjunct to current pharmacological modalities of postoperative pain control as well as its potential impact on patient satisfaction. these questions will be answered using a randomized controlled trial.

the field of facial plastic surgery continues to grow as evidenced by the increasing number of services sought by both men and women each year. among these procedures, rhinoplasty remains one of the most popular surgeries, ranking in the top three most performed cosmetic surgical procedures according to the 2017 plastic surgery statistics report. a key factor in determining the success of rhinoplasty is overall patient satisfaction. although many patient-reported outcomes tools have been developed in this space, there is a paucity of research aimed at understanding how physicians can improve patient satisfaction in this patient population. moreover, strategies to address the psychologic and coping ability for patients undergoing facial plastic surgery have not been investigated. to better provide patient-centered care, physicians should seek to understand the psychosocial impact of perceived nasal deformity and identify patients who may benefit from additional support interventions to complement current rhinoplasty treatment plans. this is a prospective repeated measures study examining psychosocial status as measured by validated psychometric instruments. the intervention group will participate in mindfulness meditation using a phone application. assessment of social functioning and quality of life will be conducted using survey instruments.

Eligibility criteria:
inclusion criteria: * patients 18 years of age or older * patients who will undergo rhinoplasty * patients with access to a smart-phone exclusion criteria: * patients younger than 18 years of age * non-english speakers * patients without smart-phone access

Keywords: mindfulness meditation patient satisfaction rhinoplasty pain control quality of life
evaluation of visual outcomes in patients with complex corneas implanted with the ic-8 iol

Conditions: Cataract; Presbyopia; Irregular; Contour of Cornea

Summary: the purpose of this study is to evaluate visual outcomes in patients with complex corneas who have been previously implanted with the ic-8 iol after cataract removal.

this will be a prospective, non-randomized, single-arm, single-visit, single-center, clinical study in up to 40 patients previously contralaterally implanted with the ic-8 iol at one clinical site in singapore. the purpose of this study is to to evaluate visual outcomes in patients with complex corneas who have been previously implanted with the ic-8 iol after cataract removal. the co-primary study endpoints are monocular uncorrected distance, intermediate, near visual acuities.

Eligibility criteria:
inclusion criteria: 1. minimum 22 years of age; 2. able to comprehend and have signed a statement of informed consent; 3. availability, willingness, ability and sufficient cognitive awareness to comply with examination procedures and study visit(s); 4. having complex corneas prior to cataract surgery; 5. previous cataract surgery and ic-8 iol implantation in the eye (implanted for 3 months or longer prior to study participation). exclusion criteria: 1. baseline visual acuity worse than 20/25 bcdva in either eye; 2. presence of ocular abnormalities or conditions other than corneal irregularities that could confound the study outcome(s), such as: 1. strabismus or amblyopia 2. retinal or macular abnormalities 3. recurrent and/or persistent ocular inflammation 4. known pathology that may affect visual acuity to a level worse than 20/25 bcdva 3. previous intraocular surgery, except cataract surgery, pterygium surgery, or corneal procedures (other than corneal-cross linking); 4. previous corneal cross-linking procedure with any corneal haze; 5. conditions requiring planned ocular surgical intervention, except nd:yag capsulotomy; 6. severe dry eye or other conditions (such as hormonal fluctuations) that could lead to unstable refraction and/or visual acuity measurements or eye discomfort even with ocular lubricants or dry eye medication; 7. patient is pregnant or nursing.
c reactive protein in home quarantined coronavirus disease 2019 (covid -19) patients.

Conditions: COVID -19

Summary: during the peak of the second covid -19 wave, the hospitals were over-crowded. many covid -19 positive patients had to stay at home and reach out to their family physicians for guidance. medical follow-up for these patients was a daunting challenge. as in - patient hospital facilities were not readily accessible due to over crowding, early objective tests to identify home quarantined patients prone to deterioration and timely medical intervention to avoid hospitalization were required. based on early assessment of inflammatory markers like crp and clinical signs like persistent high-grade fever, need-based early medical intervention was initiated in home quarantined covid -19 patients prior to the onset of hypoxia, in order to avoid complications and hospitalization

25 home quarantined covid -19 patients who contacted online for medical guidance underwent clinical and biochemical evaluation. radiological evaluation was done only if indicated. based on early objective biochemical tests like elevated crp and clinical signs like persistent high-grade fever on the third or fourth day after onset of symptoms, early medical treatment was initiated prior to onset of hypoxia. all the 25 patients recovered without any complications and did not require hospitalization.

Eligibility criteria:
inclusion criteria: 1. covid -19 positive patients under home quarantine 2. patients consulting online on the 3rd or 4th day after the onset of symptoms. 3. patients with oxygen saturation 94% and above. exclusion criteria: 1. patients consulting online on or after 5th day of onset of symptoms. 2. patients with oxygen saturation less than 94% during the initial presentation. 3. systemic disease known to increase crp levels.

Keywords: covid -19; home quarantine; c-reactive protein (crp); d-dimer, early intervention prior to onset of hypoxia
freestyle libre pro use in primary & secondary care

Conditions: Diabetes Mellitus

Summary: the purpose of this study is to evaluate the impact of varying amount of freestyle libre pro wear as measured by time in range.


Eligibility criteria:
inclusion criteria: * age at least 18 years. * type 2 diabetes treated with insulin therapy for at least 6 months prior to study enrolment. * hba1c between 58 and 108 mmol/mol (7.5 and 12.0%) inclusive. exclusion criteria: * age at least 18 years. * type 2 diabetes treated with insulin therapy for at least 6 months prior to study enrolment. * hba1c between 58 and 108 mmol/mol (7.5 and 12.0%) inclusive. * participant is currently prescribed animal insulin. * total daily dose of insulin (tdd) is \>1.75 iu/kg at entry to the study. * concomitant disease or condition that may compromise patient safety including and not limited to; cystic fibrosis, severe mental illness, a diagnosed or suspected eating disorder or any uncontrolled long term medical condition. * has a pacemaker or any other neurostimulators. * currently prescribed oral, intramuscular or intravenous steroid therapy for any acute or chronic condition or requires it during the study period. * currently receiving dialysis treatment or planning to receive dialysis during the study. * women who are pregnant, plan to become pregnant or become pregnant during the study. * participating in another study of a glucose monitoring device or drug that could affect glucose measurements or management. * currently using / has previously used a sensor based glucose monitoring system (including retrospective glucose monitoring system) within the last 6 months. * currently using continuous subcutaneous insulin infusion (csii). * known (or suspected) allergy to medical grade adhesives. * in the investigator's opinion the participant is unsuitable to participate due to any other cause/reason.

Keywords: diabetes mellitus sensing technology