Kornimate/medical-research-clean huggingface dataset:
intraoperative assessment of pulsatile aneurysm wall motion during endovascular aneurysm repair

Conditions: Abdominal Aortic Aneurysm; Endovascular Abdominal Aortic Aneurysm Repair; Ultrasound

Summary: endovascular abdominal aortic aneurysm repair (evar) aims to reduce the risk of aneurysm (aaa) rupture by reducing the blood pressure transmitted to the wall of the aneurysm. aneurysms that remain pressurized despite evar may continue to grow, therefore requiring additional surgical interventions. the purpose of this study is to infer the reduction of pressure transmitted to the aneurysm wall by using intraoperative ultrasound ('m-mode') to assess the pulsatility of the aneurysm wall. the hypothesis is that intraoperative reduction in aneurysm wall pulsatility after evar will correlate with improved aneurysm sac size reduction.

endovascular abdominal aortic aneurysm repair (evar) aims to reduce the risk of aneurysm (aaa) rupture by reducing the blood pressure transmitted to the wall of the aneurysm. unfortunately, this procedure is not always successful, and patients need to return to the operating room for further procedures because the aneurysm wall remains pressurized and the aneurysm continues to grow. currently, there is no standard non-invasive way of measuring aneurysm pressure. the purpose of this study is to infer the reduction of pressure transmitted to the aneurysm wall by using intraoperative ultrasound ('m-mode') to assess the pulsatility of the aneurysm wall. the hypothesis is that intraoperative reduction in aneurysm wall pulsatility after evar will correlate with improved aneurysm sac size reduction. this is clinically relevant because physiologic intraoperative feedback of aneurysm pressure may potentially influence surgical decision making in the future, reducing unnecessary re-interventions. this will also improve our understanding of the intraoperative physiologic response to evar. our primary research question is in patients receiving elective endovascular repair of abdominal aortic aneurysms (evar), does the change in intraoperative ultrasound estimated aneurysm wall pressure during evar correlate with aneurysm sac size reduction 1 year after surgery? secondary objectives are to assess correlation between intraoperative ultrasound estimated aneurysm wall pressure and endovascular leaks and aneurysm-related re-interventions. a prospective, observational, assessor-blinded and surgeon-blinded study will be conducted at the toh civic campus in ottawa, on in order to satisfy the objectives of the study.

Eligibility criteria:
inclusion criteria: * elective endovascular aneurysm repair (evar) surgery * infrarenal abdominal aortic aneurysm * age greater than 18 years old exclusion criteria: * prior abdominal aortic aneurysm procedures * inability to visualize aneurysm on ultrasound * inability to provide consent * irregular arrhythmias

Keywords: abdominal aortic aneurysm endovascular abdominal aortic aneurysm repair ultrasound m-mode evar
related studies of imaging features and prognosis between pancreatic neuroendocrine tumors and pancreatic cancer

Conditions: Neuroendocrine Tumor of Pancreas; Carcinoma, Pancreatic; CT

Summary: 1. imaging findings (including ct and mri images) of both well-differentiated g3 pnet and poorly differentiated pnet were studied; 2. the ct imaging findings of g3 stage pnet and pancreatic cancer were compared to establish a logistic regression diagnostic model, and the survival analysis of the two was compared. 3. cox regression was used to study the risk factors for survival prognosis of well-differentiated and poorly differentiated pnet based on ct image features

according to the latest who classification of neuroendocrine neoplasms (net) in 2019, pancreatic neuroendocrine neoplasms (pnet) are divided into well-differentiated and poorly differentiated pnets.the former is divided into g1, g2, and well differentiated g3.there are few studies on the survival outcomes of these two differentiated pnet types.the g3 imaging manifestations of the two types of differentiation have not been studied yet, and g3 pnet is often clinically misdiagnosed as pancreatic cancer, so it is necessary to differentiate the imaging manifestations and survival time of the two types. a total of 71 patients with pnet in our hospital from january 2012 to january 2019 and 58 patients with pancreatic cancer from february 2014 to august 2015 were retrospectively collected. complete survival time data of all patients after telephone follow-up were obtained.since g3 pnet is very rare, the investigators enrolled 9 patients with g3 pnet in the first affiliated hospital of zhejiang university school of medicine and 7 patients with g3 pnet in the affiliated hospital of air force military medical university from january 2013 to october 2018. ct images of pnet and pancreatic cancer were analyzed independently by two radiologists specializing in abdominal diagnosis, in which g3 lesions were evaluated simultaneously on mri images and the others were evaluated only on ct images.records clinical data and imaging characteristics: gender, age, tumor markers, tumor shape, size, tumor characteristics, edge, the expansion of the shrinking, pancreas, pancreatic pancreatitis, enhancement scan, arterial phase and portal phase lesions and the ratio of pancreatic parenchyma around, liver metastasis, peripheral vascular invasion, lymph node metastasis.

Eligibility criteria:
inclusion criteria: 1. diagnosis by pathology and detailed pathological information 2. enhanced ct examination or biopsy were performed within 2 months before surgery 3. there was no preoperative radiotherapy or chemotherapy exclusion criteria: 1. no ki-67 index 2. ct value cannot be measured by roi because of pancreatic atrophy and other reasons 3. no enhanced images or missing images
self-administered intralesional injections for acne

Conditions: Acne Vulgaris

Summary: the goal of this clinical trial is to test the safety of intralesional injections of triamcinolone self-administered into acne lesions via an injection assistance device. the main question\[s\] it aims to answer are: * is use of the injection assistance device safe? * is delivery of triamcinolone to acne lesions via the injection assistance device efficacious? participants will self-inject low dose triamcinolone into acne lesions and track lesion response via photos and survey for 14 days following injection.

this is an open-label, prospective, single-arm study. approximately 150 subjects will be enrolled at approximately 3 study sites. all subjects will receive standard-of-care intralesional injection with triamcinolone using an injection assistance device (i.e., for self-administered intralesional injections) at visit 1 (day 1). subjects will then submit photos via secure photographic app for asynchronous follow up on day 2 (24-hours post-injection), day 3 (48-hours post-injection), day 4 (72-hours post-injection), day 7, and day 14. efficacy assessments (target lesion assessments) will be conducted remotely by the investigator at time of each photo submission. subjects will conduct lesion pain assessments and satisfaction assessments at the time of each remote check-in. participants will be invited to also have additional photography captured by the study team at the study site or at a location as per participants' convenience.

Eligibility criteria:
inclusion criteria: 1. outpatient, male or female of any race, 18 years of age or older. female subjects of childbearing potential must have a negative upt at baseline. 2. diagnosed with facial acne vulgaris. 3. at least one (1) identifiable inflammatory lesion that, in the opinion of the investigator, is clinically indicated for standard-of-care intralesional injection(s) of triamcinolone. 4. owner of smartphone with capacity for front-facing photography and app download from apple app store or google play. 5. able to follow study instructions and likely to comply with virtual follow-up requirements. 6. in good general health as determined by medical history at the time of screening (investigator discretion). 7. sign the irb-approved icf (including hipaa authorization) prior to any study-related procedures being performed. exclusion criteria: 1. female subjects who are pregnant or breast-feeding. 2. known hypersensitivity or previous allergic reaction to any constituent of triamcinolone injection. 3. active cutaneous viral infection in any treatment area at baseline. 4. have concomitant skin disease or infection (other than acne) or presence of skin comorbidities in the areas of skin where study device will be used. 5. history of poor cooperation or unreliability (investigator discretion). 6. subjects who are investigational site staff members or family members of such employees. 7. exposure to any other investigational device within 30 days prior to visit 1.
study for evaluating the real use of inhaled aztreonam lysine in patients with cystic fibrosis

Conditions: Cystic Fibrosis

Summary: the aim of this observational trial is to evaluate the pulmonary function in cystic fibrosis patients that have been treated with inhaled aztreonam lysine comparing the previous 12 months before the treatment and the forward 12 months after initiating the treatment.


Eligibility criteria:
inclusion criteria: * patients above 6 years old that have been treated with aztreonam lysine (azli) at any time within 12 months before starting the treatment * diagnosis of cystic fibrosis confirmed * chronic infection by pseudomonas aeruginosa * patients can be treated with any inhaled antibiotic before or after azli treatment * patients have to have the following fev1 measures: 12 months before starting azli; at azli initiation; 12 months after starting azli * for lung transplant patiens, only data before the transplant will be collected. exclusion criteria: * non applicable
mindfulness training in adults with adhd

Conditions: ADHD

Summary: the primary aim of this study is to investigate clinical effectiveness of mindfulness training versus treatment as usual (tau) in adults with attention deficit hyperactivity disorder (adhd). the secondary aim is to assess whether mindfulness training is cost-effective compared to tau in adults with adhd from a societal perspective.

rationale attention deficit hyperactivity disorder (adhd) is a common neurodevelopmental disorder with a high persistence into adulthood. patients with adhd are primarily offered stimulant medication. however, not all patients are willing to take medication, some suffer from unacceptable side-effects and for many medication does not reduce their symptoms to the degree they would wish for. therefore, there is a strong need for effective psychosocial interventions that are both accessible to a large group of patients and have been shown to be cost-effective, such as mindfulness training. objective to examine the (cost)effectiveness of mindfulness versus treatment as usual (tau) in adults with attention deficit hyperactivity disorder (adhd). hypothesis mindfulness training will result in less adhd symptoms, a better executive functioning, a better quality of life, and lower health care and societal costs. study design randomised trial comparing mindfulness in addition to tau with tau alone. baseline, end of treatment, follow-up 1 (6 months after baseline) and follow-up 2 (9 months after baseline) assessments will be done by blinded assessors and self-report questionnaires. after 9 months, patients allocated to the tau condition will be offered mindfulness as well. study population n=120 adults with adhd according to the dsm-5 using a structured psychiatric interview, referred to radboudumc in nijmegen, reinier van arkel in 's hertogenbosch and dimence in deventer. intervention the investigators have developed a treatment protocol of mindfulness for adhd based on both the mindfulness-based cognitive therapy (mbct) (segal, williams \& teasdale, 2013) and the mindfulness training for adhd developed by zylowska (2012). standard intervention to be compared to treatment as usual, usually consisting of psychostimulants and psycho-education. cost-effectiveness analysis/ budget impact analysis annual health care and societal cost savings are expected to be €1,2 million and €15,4 million, respectively.

Eligibility criteria:
inclusion criteria: the investigators will include patients of 18 years and older who meet the following criteria: * a primary diagnosis of adhd, according to the criteria of diagnostic and statistical manual of mental disorders - 4th edition (dsm-iv-tr) based on a structured diagnostic interview for adhd, in adults (diva) * capable of filling out questionnaires in dutch exclusion criteria: * depressive disorder with psychotic symptoms or suicidality * active manic episode * borderline or antisocial personality disorder * substance dependence * autism spectrum disorder * tic disorder with vocal tics * learning difficulties or other cognitive impairments * former participation in a mbct or mbsr course

Keywords: mbct mindfulness adhd
ultrasound-guided supraclavicular brachial plexus block in elderly

Conditions: Arm Injuries; Anesthesia

Summary: the aim of this study is to determine the minimum effective volume of local anesthetic (50:50 mixture of 0.5% levobupivacaine and 2% lidocaine) required to produce an effective us-scb for surgical anesthesia in 50% of patients and to calculate the effective volume required to produce an effective us-scb in 95% of the patients (meav95) in elderly group (\>65 years) and in middle aged group (\<45years) of patients.

we believe that known data regarding the minimum anesthetic volume required for effective us-scb from middle age population can not be applicable to the elderly population since our preliminary data, presented at euroanesthesia meeting in amsterdam, 2011, and published in abstract form in the european journal of anaesthesiology, showed that involutional changes of brachial plexus in elderly, assessed by measuring the cross-sectional area (csa) of brachial plexus at the first rib, allowed a 35% reduction in local anesthetic volume for an effective us-scb for surgical anesthesia in elderly patients in comparison with the younger patients.

Eligibility criteria:
inclusion criteria: * asa 1 - 3 elderly patients (\>65 years) scheduled for hand surgery * asa 1-3 middle aged patients (\<45 years) exclusion criteria: * cognitive impairment * coagulopathy * allergy to local anesthetics * infection at the puncture site, * body mass index \> 35 kg/m2

Keywords: ultrasound brachial block levobupivacaine minimum volume minimum volume of levobupivacaine 0,5%
endoscopic drainage of collections after pancreatic surgery

Conditions: Pancreatic Cancer

Summary: the pancreatic surgery causing some pancreatic collections. and in a number of case, this surgery can require a surgical resumption, a percutaneous drainage or an endoscopic drainage. the endoscopic care of the treatment of pancreatic collections post-surgery is not yet standardized. after failure of the medical treatment, the drainage of collections by echo-endoscopy was described. there are not much series on this specific subject. only 2 series contain more than 20 patients with 31 patients for the most important. the timing and the technical choice of the endoscopic treatment as well as the long-term follow-up are not clear. the purpose of this study is to estimate the success and the complications of the endoscopic drainage by echo-endoscopy according to the techniques of drainage and the timing of the endoscopic treatment. the not estimated long-term follow-up will be also considered.


Eligibility criteria:
inclusion criteria: * age \> 18 years * patient having a pancreatic surgery complicated with a post-operative collection drained endoscopically exclusion criteria: * contraindication surgery
pcrit and tpp for risk stratification in patients with sepsis

Conditions: Sepsis

Summary: the goal of this observational study is to learn about the roles of critical closing pressure and tissue perfusion pressure in monitoring hemodynamic status, evaluating organ damage, and predicting mortality risk in patients with sepsis. the main question it aims to answer is: • whether increases in critical closing pressure or tissue perfusion pressure are associated with a reduced risk of poor prognosis? within the 24 hours following the diagnosis of sepsis, patients will be categorized into four groups based on their 24-hour mean critical closing pressure (pcc) and tissue perfusion pressure (tpp) estimated from the hourly hemodynamic data within 24 hours. outcomes will then be compared across these different groups. the study has been approved by the medical ethics committee of peking union medical college hospital (k24c1937 and k25c0792).

to validate the reliability of mean pcc estimated in the primary analysis, we prospectively collected hemodynamic data over a 24-h period from adult icu patients with invasive arterial monitoring. two methods were employed to estimate the mean pcc for reliability validation. based on the results of preliminary experiment, the sample size calculation showed that at least 12 individuals were needed for reliability validation.

Eligibility criteria:
inclusion criteria: * age ≥18 years; * sepsis was diagnosed according to sepsis 3.0 criteria; * icu stay exceeding 24 hours after enrollment; * undergoing continuous monitoring of vital signs. exclusion criteria: * significant absence of blood pressure and heart rate data within 24 hours of enrollment; * pregnancy or breastfeeding; * brain death.

Keywords: sepsis critical closing pressure tissue perfusion pressure risk stratification
effect of skanlab regarding knee arthrosis

Conditions: Arthrosis

Summary: the purpose is to find out the effect of skanlab at knee arthrosis.

the patients diagnosed with knee arthrosis will be treated with skanlab twice a week for four weeks.

Eligibility criteria:
inclusion criteria: * knee arthrosis in one or both legs exclusion criteria: * pacemaker * infusion pump * cancer * diabetes * pregnancy * blood clots * bacteriological inflammation * reduced sensitivity in the treatment area.
prosthesis loosening imaging with dual energy and tomosynthesis

Conditions: Hip Prosthesis Imaging

Summary: the purpose is to determine diagnostic performances of flat panel dual energy arthrography and arthro-tomosynthesis in identification of loosening of painful hip prosthesis, taking as reference the results of surgery performed 6 months after arthrography. secondary purposes are: * to describe the level of concordance of each technique with the indication for surgery * to study inter-technique concordance with kappa coefficient * to study the relationship between density differential between 2 acquisitions and grey level on subtraction, i.e. subtraction quality according to metal

hip arthroplasty has become one of the most performed orthopedic procedures. actual average lifetime of total hip prosthesis is approximately 15 years. some complications are inevitable. total hip prosthesis imaging, performed to search for a complication or wear, is difficult and depends on many techniques. subtracted arthrography is a good technique but its access is limited because it needs an angiography room. in this study patients undergo standard arthrography, dual energy arthrography, arthro-tomosynthesis and arthro-tomography.

Eligibility criteria:
inclusion criteria: * patients sent for arthro-tomography of painful prosthesis, without contraindications to arthrography or injection of contrast agent * aware and cooperative * signed informed consent * affiliation to social security exclusion criteria: * any contraindication to arthrography or injection of contrast agent * pregnant or possibly pregnant women * patient under guardianship * refusal or impossibility of informed consent
impact of sski pre-treatment on blood loss in thyroidectomy for graves disease

Conditions: Graves Disease; Hyperthyroidism

Summary: the purpose of this study is to determine whether a brief course of sski (saturated solution of potassium iodide) administered preoperatively provides any benefit in the surgical management of patients undergoing thyroidectomy as definitive management of their graves disease.

historically potassium iodide was given to patients for 1 week prior to thyroidectomy. this common practice was used to decrease thyroid function and prevent thyroid storm during the thyroidectomy. however, in modern practice, nearly all patients presenting for surgical management have been made euthyroid through the use of medications such as propylthiouracil. despite this potassium iodine continues to be administered with the presumption that it decreases the friability of the gland making surgery easier, with less blood loss. the outcomes to be measured in this surgery are operative time, operative complications and blood loss.

Eligibility criteria:
inclusion criteria: * adult patients with a clinical diagnosis of graves disease * patients who have selected surgical resection as treatment of their graves disease * prior use of anti thyroid medication so that patient is clinically and biochemically euthyroid exclusion criteria: * patients deemed unfit for surgery by operating surgeon or anesthesist * patients who are clinically hyperthyroid or have t3 or t4 levels 2x the upper limit of normal

Keywords: graves disease
a safety study of sgn-cd19a for leukemia and lymphoma

Conditions: Burkitt Lymphoma; Precursor B-cell Lymphoblastic Leukemia-Lymphoma

Summary: this is a phase 1, open-label, dose-escalation, multicenter study to evaluate the safety and tolerability of sgn-cd19a in adult and pediatric patients with relapsed or refractory b-lineage acute lymphoblastic leukemia (b-all), burkitt lymphoma or leukemia, or b-lineage lymphoblastic lymphoma (b-lbl).


Eligibility criteria:
inclusion criteria: * adult patients must be relapsed or refractory to at least 1 prior multi-agent systemic therapy. pediatric patients must be relapsed or refractory to at least 2 prior multi-agent systemic therapies. patients with acute lymphoblastic leukemia who are philadelphia chromosome-positive must have failed a second generation tyrosine kinase inhibitor. * eastern cooperative oncology group status of 2 or lower * pathologically confirmed diagnosis of b-lineage acute lymphoblastic leukemia, burkitt leukemia or lymphoma, or b-lineage lymphoblastic lymphoma * measurable disease exclusion criteria: * allogeneic stem cell transplant within 60 days, active acute or chronic graft-versus-host disease (gvhd), or receiving immunosuppressive therapy as treatment for gvhd

Keywords: burkitt lymphoma antibodies, monoclonal antibody-drug conjugate b-lineage acute lymphoblastic leukemia b-lineage lymphoblastic lymphoma burkitt leukemia monomethylauristatin f antigens, cd19 drug therapy