Kornimate/medical-research-clean huggingface dataset:
foam tape allergy a sticky situation

Conditions: Medical Adhesive Allergy; Dermatologic Conditions; Dermatologic Lesions

Summary: foam tape is commonly used in the emergency department as a dressing over chest tubes owing to its occlusive and compressible properties. there is a paucity of data regarding the incidence of significant cutaneous reactions to this material. the investigators conducted a prospective trial to evaluate the incidence of dermatitis following application of foam tape to the upper arm of a cohort of healthy volunteers.

this was a prospective, interventional trial. the investigators enrolled a cohort of consenting, healthy physicians, nurses, and ancillary staff at a teaching facility who did not have known hypersensitivity to foam tape. study investigators applied a 2x2 inch piece of 3m micro-foam adhesive to the medial aspect of each subject's upper arm. the contralateral arm served as a reference for comparison. the adhesive remained in place for 48 hours and the study authors assessed patients utilizing the previously validated cutaneous irritancy scoring system (ciss). categorical variables analyzed by chi-square, continuous variables with t-tests.

Eligibility criteria:
inclusion criteria: * age 18 - 70 * no reported history of dermatologic conditions * no active dermatologic lesions * able to provide written consent to participation in the study. * resident and/or ancillary staff exclusion criteria: * hospitalized patients * adults unable to consent. * prisoners * adults with anaphylaxis to medical adhesives

Keywords: dermatology contact dermatitis
early or late cord clamping in the depressed neonate

Conditions: Neonatal Disorder; Asphyxia Neonatorum

Summary: this study evaluates the hypothesis that delayed compared to early umbilical cord clamping will improve neonatal transition in terms of circulation and breathing during resuscitation.

at the time of birth, the infant is still attached to the placenta via the umbilical cord. the infant is usually separated from the placenta by clamping the cord with two clamps. early cord clamping has been generally advised to be carried out in the first 30 seconds after birth, regardless of whether the cord pulsation has ceased. however, arguments against early cord clamping include the reduction in the amount of placental transfusion and any associated benefits of extra blood volume, as delayed clamping allows time for a transfer of the fetal blood in the placenta to the infant at the time of birth. the study will evaluate the effect of early versus delayed cord clamping in a low-income setting in children that do not spontaneously start to breathe. the randomized controlled trial will be carried out at paropakar maternity and women's hospital (pmwh) in kathmandu. the trial will fill several important gaps in relation to early and delayed cord clamping and results.

Eligibility criteria:
inclusion criteria: * newborn in need of resuscitation measures (no or irregular breathing despite thorough drying and additional stimulation within one minute after birth) * gestational age ≥ 33 weeks exclusion criteria: monochorionic twins (from an ultrasound scan) or clinical evidence of twin-twin transfusion syndrome, triplets or higher order multiple pregnancy, and fetuses with known congenital malformation

Keywords: resuscitation cord clamping
observational, bivariate analysis of clinical big data in patients with cervical cancer

Conditions: Progression-free Survival Was Defined From Date of Surgery to Disease Progression Post-surgery or Death or Last Follow-up; Overall Survival Was Defined as Time From Surgery to Death From Any Cause or Last Follow-up

Summary: this is a large non-interventional observational bidirectional study planned to collect clinically relevant data and prognostic follow-up information of patients with cervical cancer who were seen at our center from 2010.01.01 to the end of this study.

this study is a large-scale observational, bi-directional analytical study, which collects clinical data from patients with cervical cancer who have received treatment in the department of gynecologic oncology of the first hospital affiliated to the university of science and technology of china (anhui provincial hospital), including age, weight, bmi, menopausal status, history of the current disease, past history, specialized examinations, results of tests, results of genetic testing, pathology-related data, and information related to surgery, etc. the diagnosis, subsequent treatment, and follow-up of the subjects follow the routine clinical procedures of the clinical center. the diagnosis and subsequent treatment and follow-up of the subjects followed the routine clinical procedures of the clinical center, and the follow-up data of the enrolled patients were collected every six months: imaging, tumor markers, recurrence and treatment. and clinical big data analysis. therefore, patients who meet the enrollment criteria can be included, and the sample size is based on the actual number of cases included.

Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years; 2. patients with a clear pathological diagnosis of cervical cancer; 3. all patients included in this study were diagnosed after 1 january 2010 4. diagnosis or treatment of cervical cancer at the centres covered by this study; 5. exemption from informed consent or signing of an informed consent form. exclusion criteria: 1. loss of contact during the follow-up period for no apparent reason; 2. discharged from the hospital for follow-up treatment at an outside institution with unknown treatment status; 3. the investigator considers the patient unsuitable for participation in this study; 4. cases where the clinical diagnosis is in doubt or unclear.
investigation of grip strength, pain and anxiety levels in dentists

Conditions: Grip; Muscle Disorder; Pain, Chronic; Anxiety

Summary: the aim of the study is to evaluate the relationship between professional experience and grip strength, pain threshold and anxiety level in dentists. as a result of the results obtained, we aim to contribute an original study to the literature and to increase awareness by informing the dentists participating in the study.

our hypotheses: h1: professional experience has an effect on hand grip strength in dentists. h2: professional experience has an effect on finger grip strength in dentists. h2: professional experience has an effect on pain in dentists. h3: professional experience has an effect on anxiety level in dentists. the unique value of our study is that it is the first study to examine the relationship between dentists' professional experience and grip strength, pain, and anxiety. when we look at the literature, we have not found any studies examining the effect of dentists' professional experience on grip strength and pain. in the study, grip strength, pain threshold, and forearm grip strength will be evaluated. grip strength will be assessed with a jamar hand dynamometer, pinch grip with a baseline brand pinchmeter, pain threshold with a dolorometer, and forearm grip strength with a handheld dynamometer. anxiety will be assessed with the beck anxiety questionnaire.

Eligibility criteria:
inclusion criteria: * graduating from the faculty of dentistry * having 1 year or more professional experience exclusion criteria; * having received physical therapy from any area in the last 6 months or currently receiving physical therapy, * having a congenital musculoskeletal deformity, * having a neurological or rheumatic disease, * having undergone surgery due to a musculoskeletal disorder.

Keywords: pain pain thereshold
characterizing disease biology, treatment and toxicity in older adults with hepatocellular carcinoma

Conditions: Carcinoma, Hepatocellular

Summary: this is an observational, prospective cohort study that will recruit a diverse sample of 84 participants with newly diagnosed with unresectable, advanced hepatocellular carcinoma (hcc) at the ut health cancer center in san antonio. this study uses geriatric assessment tools with participants 65 years and older and collects adverse events and exploratory markers of aging for all participants.

the results from this study will allow us to identify unique disease characteristics of older participants and to study treatment patterns that may be barriers to treatment and risk factors for increased morbidity. characteristics of comprehensive geriatric assessment will be obtained prior to standard interventional treatment for participants that are 65 years or older. observations will be made of treatment toxicities and cellular senescence with treatment outcomes. findings from this study will result in the development of r01 intervention studies that develop and validate a treatment algorithm based on these associations to provide older adults with a personalized treatment plan.

Eligibility criteria:
inclusion criteria: * histologically or radiographically (ct or mri) confirmed newly diagnosed hepatocellular carcinoma. * age 18 years and older. * patients with advanced, unresectable hcc as determined by the treating physician. exclusion criteria: * patients with resectable hcc who are still candidates for locoregional therapy * patients receiving prior systemic or locoregional therapy
goal-directed fluid therapy on complications after pancreaticoduodenectomy

Conditions: Pancreaticoduodenectomy; Stroke Volume Variation

Summary: optimal fluid balance is critical to minimize anastomotic edema in patients undergoing pancreaticoduodenectomy. this study examined the effects of decreased fluid administration on rates of postoperative pancreatic leak and delayed gastric emptying.

retrospective study of 10564 patients undergoing pancreaticoduodenectomy at a single institution from january, 2015 through july, 2016. stroke volume variation (svv) was tracked and titrated during the procedure. all patients were seen preoperatively in the department clinic setting, and indications for pancreaticoduodenectomy were for pancreatic adenocarcinoma, neuroendocrine tumors, chronic pancreatitis, non-adeno malignancy, and other benign. benign and malignant disease. patients were excluded if they had any of the following during surgery: venous resection and reconstructive involving the portal venous system; estimated blood loss exceeding two liters; high dose steroid administration; use of irreversible electroporation for margin enhancement; lack of svv equipment or inconsistent svv recordings; use of the robotic surgical system. primary outcomes measures were recorded for each patient were: pancreatic leak and delayed gastric emptying. pancreatic leak was defined according to the international study group for pancreatic fistulas: "an external fistula with a drain output of any measurable volume after postoperative day three with an amylase level greater than three times the upper limit of the normal serum value." delayed gastric emptying was defined clinically as persistent postoperative emesis requiring nasogastric tube placement, prokinetic agents, or hospital readmission for endoscopic gastrostomy placement. a comparative analysis of postoperative complications was performed between patients with a median svv \ 12. the investigators chose an svv value of greater than 12 to represent a "dry" state because previous studies have shown that this value represents decreased fluid administration.

Eligibility criteria:
inclusion criteria: • pancreatic adenocarcinoma, neuroendocrine tumors, chronic pancreatitis, non-adeno malignancy, and other benign lesion exclusion criteria: * venous resection and reconstructive involving the portal venous system * estimated blood loss exceeding two liters * high dose steroid administration * use of irreversible electroporation for margin enhancement * lack of svv equipment or inconsistent svv recordings * use of the robotic surgical system

Keywords: fluid therapy gastric emptying pancreatic leak pancreaticoduodenectomy stroke volume variation
expanded access to elotuzumab (empliciti) for multiple myeloma

Conditions: Multiple Myeloma

Summary: at bms, we work with physicians/investigators to make investigational products available to patients with life-threatening diseases that have exhausted other treatment options and where there is a reasonable expectation of benefit over risk. when contacted by a treating physician, bms will consider requests for providing early patient access to elotuzumab in patients with multiple myeloma who are residents of belgium, thailand, turkey, argentina, and colombia.

choosing to participate in an early patient access program is an important personal decision. talk with your doctor and family members or friends about deciding to participate in an early patient access program. to learn more about early patient access programs, your doctor may contact bms using the information provided below.

Eligibility criteria:
specific eligibility criteria must be met for access outside of a clinical trial. these inclusion criteria include: * the illness must be serious or life threatening * there are no other viable options (including approved products or active clinical trials) * there is sufficient evidence that the potential benefit to the patient would likely outweigh the potential risks based on what is known at the time * other defined inclusion/exclusion criteria could be applicable.
evaluation of slit2 in systemic lupus erythematosus and systemic sclerosis patients

Conditions: Systemic Lupus Erythematosus

Summary: 1.assessment of slit2 level in sle patients and its correlation with disease activity. 2-assessment of slit2 level in ssc patients and its correlation with disease activity

systemic lupus erythematosus (sle) is the most serologically and clinically diverse autoimmune disease. immune dysregulation leads to excess production of autoantibodies and immune complexes. excess complement activation, and insidious tissue inflammation in patients with sle. sle is characterized by multisystem involvement commonly affecting the skin, renal, and musculoskeletal systems . lupus nephritis is an important cause of both acute kidney injury and chronic kidney disease that can result in end-stage renal disease. its pathogenic mechanisms are characterized by aberrant activation of both innate and adaptive immune responses, dysregulation of inflammatory signaling pathways, and increased cytokines production . systemic sclerosis (ssc) is an autoimmune disease with characteristic vascular damage and fibrosis of the skin and internal organs. diagnosis of ssc is mainly based on the clinical course and features in addition to laboratory findings including autoantibody profiles . slit2, as a member of the slit family, is secreted glycoprotein. slit2 functions by binding to its transmembrane receptor robo. robo has four isoforms (robo14). slit2-robo regulates cell functions, such as regulating leukocytes in chemotaxis and promoting endothelial cell migration and tube formation. slit2 might promote the pathogenesis of ln by affecting various cell dysfunction in addition to leukocyte infiltration. in ssc, vascular involvement is a primary event characterized by vascular tone dysfunction and microcirculatory abnormalities. many classes of guidance molecules, such as members of the secreted glycoproteins slits and their roundabout (robo) receptors, play critical roles in angiogenesis. among these, robo1 and robo4 are expressed in endothelial cells. .

Eligibility criteria:
inclusion criteria: 1. adult sle patients who fulfilled the 2019 eular/acr classification criteria for systemic lupus erythematosus . 2. adult ssc patients who fulfilled the 2013 eular / acr for ssc exclusion criteria: * individuals with other autoimmune diseases

Keywords: systemic sclerosis
effect of remote ischemic conditioning in heart attack patients

Conditions: ST-segment Elevation Myocardial Infarction (STEMI)

Summary: new treatments are required to improve health outcomes in patients with ischemic heart disease. this is especially so in developing countries such as mauritius in which optimal therapy for acute myocardial infarction may not be widely available. for example for patients presenting with a heart attack (caused by a blockage in one of the heart blood vessels) the treatment of choice would be to remove the blockage by primary percutaneous coronary intervention (pci) using an angioplasty balloon and put a stent (a spring-like structure) to keep the artery opened. however, pci is not widely available in mauritius and heart attack patients are given clot-busting therapy to remove the blockage, but this is not as effective as pci. therefore, in this research study we investigate a new cheap treatment that may help protect the heart against damage during a heart attack, called remote ischemic conditioning (ric), in which a blood pressure cuff is placed on the upper arm and inflated for 5 minute and deflated for 5 minutes a cycle which is repeated 4 times in total in patients presenting with a heart attack. by temporarily depriving oxygen and nutrients to the arm with the blood pressure cuff a protective signal can be relayed to the heart to reduce the amount of damage occurring during the heart attack and thereby prevent the onset of heart failure. study hypothesis: remote ischaemic conditioning will reduce the amount of damage occurring to the heart muscle during a heart attack..


Eligibility criteria:
inclusion criteria: * age \>18 years * presentation within 12 hours of onset of chest pain * ecg showing st-segment elevation of ≥0.1mv in two contiguous leads (≥0.2mv in leads v1-v3) exclusion criteria: -none -

Keywords: st-segment elevation myocardial infarction (stemi); thrombolysis, remote ischemic conditioning, myocardial infarct size, cardioprotection
assessing the effect of shatavari supplementation on bone and skeletal muscle health in healthy postmenopausal women

Conditions: Muscle Weakness; Osteoporosis, Postmenopausal

Summary: shatavari is a plant that grows in nepal, sri lanka, india and the himalayas and its root has long been used in ayurvedic medicine. its traditional uses include supporting women's health, particularly during breastfeeding and during the perimenopausal period. shatavari has been found to contain substances that have similar chemical properties to estrogen. a decrease in the amount of ovarian estrogen production causes the menopause and this reduction in circulating estrogen has widespread effects, including promoting a decrease in bone density. this increases the risk of bone fractures. having less oestrogen is also thought to contribute to a loss of muscle strength in postmenopausal women. as shatavari may act on the body's tissues in a similar way to estrogen, shatavari supplementation may represent one way of preventing postmenopausal bone and muscle loss. this study will investigate these questions. 24 healthy postmenopausal women aged 60 years or older will be recruited. the participants will be randomly assigned to consume shatavari (1000 mg per day, equivalent to 26,500 mg per day fresh weight shatavari) or placebo (1000 mg per day magnesium stearate) for 6 weeks. handgrip and knee extensor strength will be measured at baseline and at 6 weeks. vastus lateralis (vl) muscle biopsy samples will be obtained at baseline and at 6 weeks and analysed for markers of muscle function and protein turnover. plasma and serum samples will be collected via venepuncture and markers of bone turnover (p1np, β-ctx) will be measured at baseline and at 6 weeks. primary human osteoblasts (not obtained from these participants) will be stimulated with pooled sera from the placebo and shatavari supplementation conditions to assess markers of osteoblast (bone-building) activity.


Eligibility criteria:
inclusion criteria: * postmenopausal women (last menstrual period \> 12 months ago) * aged 60 years or older exclusion criteria: * bmi ≥ 30 * diagnosis (dexa t-score \< -2.5) and/or treatment for the prevention of osteoporosis, including treatmeat with bisphosphonates and non-bisphosphonates (including, but not limited to raloxifene, denosumab, teriparatide, calcitriol and estrogenic hormone replacement therapy). * currently taking estrogenic hormone replacement therapy or history of estrogenic hormone replacement therapy in the past 5 years via any route of administration apart from vaginal. * par-q+ screening indicates physical activity is unsuitable.
role of genetics in idiopathic pulmonary fibrosis (ipf)

Conditions: Idiopathic Pulmonary Fibrosis; Familial Pulmonary Fibrosis; Idiopathic Interstitial Pneumonia; Familial Interstitial Pneumonia

Summary: the purpose of this study is to investigate inherited genetic factors that play a role in the development of familial pulmonary fibrosis and to identify a group of genes that predispose individuals to develop pulmonary fibrosis. finding the genes that cause pulmonary fibrosis is the first step at developing better methods for early diagnosis and improved treatment for pulmonary fibrosis. the overall hypothesis is that inherited genetic factors predispose individuals to develop pulmonary fibrosis.

familial pulmonary fibrosis (fpf) is a sub-category of the idiopathic interstitial pneumonias (iips). iips are progressive lung conditions, with limited treatment options and unknown etiology. though the iips have been associated with both genetic risk factors and environmental exposures, the molecular mechanism underlying disease progression remain poorly understood. this investigation seeks to identify a group of genetic loci that play a role in the development of familial interstitial pneumonia (fip) or fpf, where 2 or more cases of iip are seen within a family.

Eligibility criteria:
inclusion criteria: * two or more family members with a clinical diagnosis of idiopathic pulmonary fibrosis (ipf) or idiopathic interstitial pneumonia (iip) * additional family members may be eligible to participate if two family members are suspected of or diagnosed as having idiopathic pulmonary fibrosis (ipf) or idiopathic interstitial pneumonia (iip) exclusion criteria: * individuals whose pulmonary fibrosis is due to a known cause rather than idiopathic * individuals whose pulmonary fibrosis is due to a broader genetic syndrome

Keywords: idiopathic pulmonary fibrosis familial pulmonary fibrosis idiopathic interstitial pneumonia familial interstitial pneumonia pulmonary fibrosis