Kornimate/medical-research-clean huggingface dataset:
effectiveness of dual task exercise training in children with cerebral palsy

Conditions: Cerebral Palsy

Summary: cerebral palsy (cp) is the most common neurological disorder in children and one of the major causes of motor disability. cp causes changes in postural and sensory integration, balance, coordination disorders and muscle weakness due to problems in muscle tone. an effective rehabilitation program is of great importance in solving many problems that can be associated with decreased balance control. researchers have stated that rehabilitation programs with repetitive special tasks are effective. the aim of the study was to compare the effects of conventional physiotherapy and dual task exercise training in addition to conventional physiotherapy on balance, mobility, physical performance and quality of life in children with cerebral palsy.


Eligibility criteria:
inclusion criteria: * hemiplegic, monoplegic, unilaterally affected or diplegic children aged 5-12 years with cerebral palsy * gross motor function classification (gmfcs) level 1 (walks without restrictions) or 2 (walks with restrictions) * understand simple commands * signing the consent form exclusion criteria: * children and their families who do not want to be involved in the study * children with vision and hearing problems * hildren with secondary orthopedic problems and children with walking aids * circumstances that would prevent carrying out assessments and exercise training or communicating
trial of an augmented mobilization strategy with plerixafor (mozobil®) in a population at risk for poor stem cell mobilization

Conditions: Multiple Myeloma; Lymphoma

Summary: poor mobilization of hematopoietic progenitors needed to support autologous transplantation is a serious clinical problem. we are investigating the role of plerixafor administered in an at risk population to augment successful stem cell collection. objectives to determine if plerixafor when administered on the day prior to planned autologous collection on first mobilization attempt in those with a peripheral blood cd34 ≤ 10x106/l will: * increase the number of patients successfully collected in one day * increase the number of patients successfully mobilized on first collection attempt * is cost neutral within a canadian setting


Eligibility criteria:
inclusion criteria: 1. participants must be 18 years of age or older 2. patients must be able to provide written consent 3. participants must have a diagnosis of lymphoma or multiple myeloma and be undergoing autologous stem cell mobilization for the purposes of asct 4. females of child bearing age will be asked to use an approved form of contraception exclusion criteria: 1. patients who are pregnant or breastfeeding 2. patients whose creatinine ≥ 250 μm 3. serum ast, alt or total bilirubin \>5x upper limit of normal 4. acute infection

Keywords: myeloma multiple myeloma or lymphoma patients undergoing mobilization for the purpose of autologous stem cell collection
lateral stair walking training after chronic stroke

Conditions: Chronic Stroke Patients

Summary: the experimental group received 15 minutes of lateral stair walking exercise and 30 minutes of traditional physiotherapy (strengthening exercise, balance training and gait training) each time. the measures were done by one experience physical therapist (not involve in the intervention) before receiving the intervention and at weeks four, eight, and twelve. it took 45 minutes for each subject to complete all measures each time.

for lateral stair walking training, the dynamic stair trainer features four steps. the height can be adjusted from 0 to 16.5 centimeters, the stair was 0.74 m in width, with each step being 16 cm deep and 10 cm long. the experimental group received different heights of lateral stair walking training according to the patients' ability. the patients went up the stairs with the affected leg up first and they went down stairs with the sound leg leading first. for safety, the subjects held a handrail during the lateral stair walking exercise. the control group received traditional physiotherapy (strengthening exercise, balance training and gait training) for 30 minutes. both the experimental group and control group received the intervention once a week for 12 weeks. all the interventions were done by the same physical therapist.

Eligibility criteria:
inclusion criteria: * subjects who were diagnosed with stroke within 6 months to 6 years by a neurologist or physiatrists, * computerized tomography scan or magnetic resonance imaging scan showed unilateral brain damage, * no obvious cognitive impairment, * no serious bone and joint problems * could follow the instructions and steps of the experiment * walked 15 meters independently. exclusion criteria: * cognitively impaired, * visually impairedor * unable to receive training due to other diseases (lung, heart, gastrointestinal tract, bone and muscle, nervous system etc.)

Keywords: lateral stair walking range of motion muscle strength
clinical evaluation of a non-invasive hypoglycemia detector in a glycogen storage disease population

Conditions: Glycogen Storage Disease

Summary: glycogen storage disease (gsd) patients frequently experience periods of hypoglycemia, putting them at risk for several complications, such as hepatomegaly, adenomas, and cirrhosis. as of now, glycogen storage disease patients are limited to using finger stick glucose meters to monitor their glycemia at home. diabetes sentry, a non-invasive hypoglycemia detector designed like a watch, has been available for diabetic patients to non-invasively alert for hypoglycemia, but has never been tested in a gsd population. the investigators propose to test the accuracy of the diabetes sentry on patients with gsd types 0, i, iii, vi, and ix, by measuring their metabolic markers every two hours, as well as whenever the device alerts for hypoglycemia. if accurate, it could be a useful tool for gsd patients in managing hypoglycemia, both clinically and at home.

as a participant the following will take place: the diabetes sentry device, which is non-invasive and is worn on the wrist will be used while an inpatient at the university of florida health \& shands hospital. participants will be monitored for the duration of the observational period on the unit, an expected average will be 24 hours. the device is designed to alarm during periods of perspiration and drops in body temperature. when this occurs, a blood draw will be taken to test for glucose, lactate, and ketone values at those times if there is not an already scheduled clinical care blood draw for normal clinical care.

Eligibility criteria:
inclusion criteria: * patients diagnosed and clinically treated at the university of florida with any of the glycogen storage diseases i, iii, vi, ix, 0 will be asked to participate in this study. exclusion criteria: * patients not clinically treated at the university of florida.
application of large volume acute normovolemic hemodilution in cardiac valve surgery

Conditions: Cardiac Valve Surgery

Summary: the application of acute normovolemic hemodilution in cardiac surgery can effectively reduce perioperative blood transfusion, reduce postoperative complications and mortality, and is a low-cost, operable and effective blood protection measure.for the application of acute normovolemic hemodilution in heart surgery, we still face an urgent problem: to what extent can acute normovolemic hemodilution achieve better "blood saving effect", that is, whether a large number of acute normovolemic hemodilution can reduce perioperative blood transfusion to a greater extent.


Eligibility criteria:
inclusion criteria: 1. audlt patients ( ≥ 18 years old); 2. elective valve surgery under cardiopulmonary bypass; 3. preoperative hemoglobin (hb) ≥ 12g/dl; (4) transfusion risk understanding scoring tool (trust) ≥ 2 (possibility of blood transfusion ≥40%). exclusion criteria: （1）low body weight (male: \ 70%;severe aortic stenosis (area \ 70% or with symptoms);（7） kidney failure (blood creatinine level \>442 mmol/l) or dialysis treatment;（8） serum albumin level (alb) is less than 25 g/l.（9） international standardized ratio (inr) \>1.5 or platelet count \<100 103/mm3;（10）inherited/acquired coagulation function defect;（11）preoperative preparation platelet;（12） contagious or infectious diseases;（13） patient or family members refused to participate in research;（14）refused to infusion of autologous blood or allogeneic blood products
fatty liver disease in nordic countries

Conditions: Non-Alcoholic Fatty Liver Disease

Summary: a prospective cohort study, which aims to systematically evaluate biomarkers and potential targets in nafld and nash.


Eligibility criteria:
inclusion criteria: * non-alcoholic fatty liver disease and * healthy volunteers exclusion criteria: * other liver diseases than non-alcoholic fatty liver disease * lack of informed consent
radiological analysis on patients with achondroplasia disorder

Conditions: Achondroplasia

Summary: achondroplasia is a genetic disorder characterized by disproportionate short stature. it affects about 1 in 2500 live births in the world. the cause of achondroplasia was identified to be a gain-of-function mutations in the fibroblast growth receptor 3 (fgfr3). in these children compression of the spinal cord at the foramen magnum stenosis can occur in early childhood which, can lead to central sleep apnea. it can lead to morbidity and mortality. a surgical intervention may be indicated in patients who present a foramen magnum stenosis. however, surgical indications are still under discussion. the objective of this retrospective study is to analyse the degree of stenosis and its clinical tolerance/evolution from radiological data monitored at the hospital femme mère enfant.


Eligibility criteria:
inclusion criteria: * boys and girls. * aged from 0 to 18 years old. * subjects with an achondroplasia diagnosis. * patients or parents/ legal guardian must provide non opposition prior to participation in the study. exclusion criteria: - patients or patient's parents or legal guardian whose have an objection for using their data.

Keywords: achondroplasia cranio-vertebral abnormalities
dynamic plantar microvascular skin response to compressive loads in at-risk diabetic and healthy control: a pilot study

Conditions: Foot Ulcer, Diabetic

Summary: the purpose of this pilot study is to compare the dynamic response of microcirculation in the skin on the bottom of the big toe after applying controlled plantar stress in 25 diabetic subjects with a history of foot ulcer and 25 age-matched healthy controls to better understand the role of local hypoxia in neuropathic foot ulceration in subjects with diabetes. the investigators hypothesize that if they apply a gait simulating load to the plantar foot and measure microvascular function, diabetic individuals will demonstrate an increased delay in reestablishing microvascular flow compared to healthy individuals.


Eligibility criteria:
inclusion criteria: * between ages 40 and 75 * history of diabetic neuropathic plantar ulcer (test subjects) * no history of diabetes (control subjects) * no peripheral sensory neuropathy (control subjects) exclusion criteria: * amputation or surgery on right great toe

Keywords: laser doppler anemometry dynamic testing of tissue mechanical property diabetic foot complications ulcer genesis
a clinical trial of pgdm1400 and pgt121 and vrc07-523ls monoclonal antibodies in hiv-infected and hiv-uninfected adults

Conditions: HIV Infections

Summary: this is a phase 1 study to evaluate the safety, tolerability, pharmacokinetics and anti-viral efficacy of the pgdm1400 and pgt121 and vrc07-523ls mabs for hiv prevention and therapy.

this is a phase 1 study to evaluate the safety, tolerability, pharmacokinetics and anti-viral efficacy of the pgdm1400, pgt121 and vrc07-523ls mabs for hiv prevention and therapy. pgdm1400, pgt121 and vrc07-523ls mabs are recombinant human igg1 monoclonal antibodies that target v1v2 (pgdm1400), a v3 glycan-dependent epitope (pgt121) and the cd4 binding site (vrc07-523ls) epitope region of the hiv envelope protein. pgt121, pgdm1400 and vrc07-523ls mab were chosen for this study because of their potency, their ability to neutralize a wide array of cross-clade hiv viruses in a complementary pattern and their proven antiviral activity in animal studies e.g., their capacity to robustly prevent and treat simian-human immunodeficiency virus (shiv) in rhesus monkeys.

Eligibility criteria:
groups 1 and 2 inclusion criteria: * hiv-uninfected males or females age 18-50 years old * willing to maintain low risk behavior for hiv infection groups 1 and 2 exclusion criteria: • confirmed hiv-infection, pregnancy or lactation, significant acute or chronic disease and clinically significant laboratory abnormalities group 3 inclusion criteria: * hiv-infected males or females age 18-65 years old * not on antiretroviral therapy with hiv-1 rna plasma level between 1,000 and 100,000 copies/ml, cd4 cell count ≥ 300 cells/ul group 3 exclusion criteria: • significant acute or chronic medical condition other than hiv infection, and clinically significant laboratory abnormalities
comparison of different ventilation mode during one-lung ventilation

Conditions: Thoracic Surgery; One Lung Ventilation; Ventilator-Induced Lung Injury

Summary: it is controversial as to which ventilation mode is better in one-lung ventilation(olv), volume controlled ventilation(vcv) or pressure controlled ventilation(pcv). this study was designed to figure out if there was any difference between these two modes on oxygenation and postoperative complications under the condition of protective ventilation(pv).

this is a single center, single blinded prospective study on two different ventilation mode during one lung ventilation for patients under video assistant thoracoscopy(vats) lobectomy. after institutional approval and written informed consent were obtained, 60 patients with primary lung cancer under vats lobectomy in zhongshan hospital fudan university were enrolled and randomized into two groups:vcv group(group v) or pcv group(group p). inclusion criteria were age between 18-75 years , asa i-ii, lateral decubitus position with at least 1h olv and preoperative fev1\>50% predicted. preoperative exclusion criteria were previous lobectomy , copd , asthma, uncompensated cardiac disease or contraindications for epidural catheter. intraoperative exclusion criteria were spo2 under 90% after intratracheal suction, reconfirmation the position of double lumen tracheal tube(dlt) and recruitment maneuver of dependant lungs.

Eligibility criteria:
inclusion criteria: * asa i-ii, lateral decubitus position with at least 1h olv and preoperative fev1\>50% predicted exclusion criteria: * preoperative exclusion criteria were previous lobectomy , copd , asthma, uncompensated cardiac disease or contraindications for epidural catheter. intraoperative exclusion criteria were spo2 under 90% after intratracheal suction, reconfirmation the position of double lumen tracheal tube(dlt) and recruitment maneuver of dependant lungs
endovascular treatment for ais in chinese municipal and county hospitals： a "real world" study-eternity registry

Conditions: Endovascular Treatment

Summary: to investigate the endovascular treatment difference between chinese city and country hospital.

endovascular treatment for ais in chinese municipal and county hospitals： a "real world" study-eternity registry is an academic , independent, pragmatic , prospective , multicenter , observational registry study . patients with acute ischemic stroke caused by anterior circulation intracranial large vessel occlusion and receiving evt were included. patients were divided into primary stroke center (county hospital) and senior stroke center (city hospital) groups. acute ischemic stroke (ais) workflow, evt procedural details and clinical outcome were compared in two groups. the aim of the study was to explore the evt difference in chinese city and county hospital.

Eligibility criteria:
inclusion criteria: (1) age ≥18 years; (2) diagnosis of ais caused by imaging-confirmed intracranial lvo, including isolated cervical internal carotid artery or tandem occlusion, intracranial internal carotid artery, middle cerebral artery (m1/m2), anterior cerebral artery (a1/a2); (3) initiation of any type of evt, including mechanical thrombectomy, emergent angioplasty via balloon or/and stent; (4).onset-to-presentation time with 24 hours; (5).patients whose onset-to-presentation time surpass 6 hours should had ctp and fulfill with dawn\[6\] or defuse's\[7\] criteria. exclusion criteria: (1) without follow up outcome; (2) posterior circulation stroke;(3)no evidence of lvo on angiogram.

Keywords: endovascular treatment acute ischemic stroke
impact of sleep deprivation on anesthesiology residents' non-technical skills

Conditions: Sleep Deprivation

Summary: sleep deprivation is common in anaesthesiology residents. its effects on technical skills have been reported with controversial results. non-technical skills (team working, situation awareness, decision making and task management) contribute to safe and efficient task performance. they have a crucial role in anaesthetic practice, especially during crisis management. the investigators hypothesized that sleep deprivation was associated with a reduced mobilisation of non-technical skills in anaesthesiology residents.

the scenario consisted in a rapid sequence induction for emergency general anaesthesia in case of acute peritonitis complicated by an anaphylactic shock secondary to the injection of succinylcholine. all scenarios were performed with the assistance of an anaesthetist nurse, facilitator of the scenario. in a second time, after patient stabilisation (defined as oxygen saturation by pulse oximetry (spo2) \> 95%, mean arterial pressure (pam) \> 65 mmhg and heart rate (hr) \< 100 bpm for at least 2 minutes) consecutive to an expected injection of 100 µg of epinephrine decided by the participant, a surgeon entered the operating room to create a dilemma regarding patient destination (continue surgery or intensive care unit admission)

Eligibility criteria:
inclusion criteria: * anesthesiology residents from paris academic hospitals exclusion criteria: * chronic sleep disorder

Keywords: anesthesiology non technical kills
a study of iguratimod in patients with active rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: this study is intended to evaluate the safety and efficacy of iguratimod in patients with active rheumatoid arthritis.

this is a multi-center, open, single arm study.

Eligibility criteria:
inclusion criteria: * subjects with a diagnosis of ra * subjects who have active ra at the time of screening * subjects who haven't used any antirheumatic drugs or have used antirheumatic drugs for more than 3 months at the time of screening * written informed consent exclusion criteria: * subjects with serious cardiovascular, renal, hematologic or endocrine diseases * pregnant or lactating women * alt\>1.5×uln, ast\>1.5×uln, cr\>135umol/l * wbc\<4×109/l，hgb\<85g/l，plt\<100×109/l * subjects with uncontrolled infection * patients with active gastrointestinal diseases (such as gastric ulcer, etc.) * allergic to any of the study drugs * history of alcoholism * subjects receiving live vaccines within 3 months prior to study entry * subjects participating in other clinical study within 3 months prior to study entry

Keywords: rheumatoid arthritis iguratimod
serum progesterone levels on the day of frozen embryo transfer (fet) and pregnancy outcomes

Conditions: Infertility; Infertility, Female; IVF

Summary: frozen embryo transfer (fet) cycles have become more common in recent years due to a push towards elective single embryo transfer (set). while it is known that progesterone supplementation during the luteal phase improves clinical pregnancy rates, there is a paucity of prospective data on the impact of serum progesterone levels on pregnancy outcomes in fet cycles. this multicentre prospective cohort study aims to investigate the association between serum progesterone levels on the day of fet and pregnancy outcomes, and to determine a serum progesterone cut-off value above which clinical pregnancy and live birth are more likely to occur. women undergoing art-fet cycles at care fertility clinics in the uk will be recruited and their serum progesterone measured on the day of frozen embryo transfer. follow-up data will be stored in electronic patient records and analysed to determine whether a low serum progesterone level on the day of fet adversely affects art outcomes.


Eligibility criteria:
inclusion criteria: * all women undergoing art with fet. exclusion criteria: * none. we aim to study the "every day" patient undergoing fet, and for this we intend to keep the population of the study as unselected as possible.
the impact of brief one-time education and coach encouragement on hydration status in child judo athletes

Conditions: Dehydration in Children; Dehydration

Summary: due to the lack of any comparative study related to effect of different hydration processes, this study aimed to compare the effectiveness of coach encouragement and hydration education in maintaining hydration status in child judo athletes

forty-seven athletes participated in a four-day training camp, during which hydration status was assessed before and after training sessions under three different conditions: no intervention (control), coach-guided fluid intake encouragement, and pre-training brief one-time hydration education. athletes were unaware of the intervention conditions assigned to each day, and the educational session was delivered without emphasizing its experimental nature. to minimize potential carryover effects, the sequence of interventions was fixed. hydration status was objectively monitored using urine specific gravity (usg) and urine color (uc) measurements.

Eligibility criteria:
inclusion criteria: * having at least three years of judo experience * having at least a green belt * being healthy enough to attend all training sessions during the camp. exclusion criteria: * having less than three years of judo experience * having orange belt or lower * not being healthy enough to attend all training sessions during the camp.

Keywords: hypohydration health athletic population combat sports