Kornimate/medical-research-clean huggingface dataset:
guaraná for radiation related fatigue in breast cancer patients

Conditions: Fatigue

Summary: we hypothesize that guaraná, a native plant from the amazon, might improve radiation-induced fatigue in breast cancer patients undergoing treatment. in order to assess this, we randomized patients to either guaraná extract or to placebo, switching the assigned treatment mid-term through the radiation.

the aim of this study is evaluate the favourable effects of guaraná in memory and cognition in humans after approval by our institutional review board, we included consenting patients with a histological diagnosis of early stage breast cancer for whom adjuvant radiation therapy was indicated. we excluded patients with a previous history of radiation therapy, anemia or clinical depression. we also excluded patients who were unable to grant informed consent or those who had medical contraindindications for the use of guaraná (because of its psycho stimulant effect) such as uncontrolled hypertension, previous history of cardiac arrhythmia and insomnia. the radiation therapy for patients who underwent mastectomy consisted of 28 fractions of 180cgy. this study had a double-blind randomized design with crossover between experimental arms. after getting informed consent, we randomized patients at the beginning of radiation treatments (phase i) to either 75 mg of guaraná extract daily (group a) or to placebo (group b). randomization was centralized by the pharmacist. halfway through the radiation treatments (phase ii), we switched patients from placebo to guaraná and vice versa. the protocol ended at the last session of radiation treatments (phase iii). in each of these three phases a new assessment of fatigue and depressive symptoms was undertaken, ie: immediately before the first radiation treatment (phase i); at switching (phase ii) and right before the start of the last radiation treatment (phase iii). at these three assessment points, patients had to complete the chalder fatigue scale,4 the md anderson brief fatigue inventory (available at http://www.mdanderson.org/topics/fatigue/) available in portuguese, and the beck inventory depression scale ii also validated in portuguese. we conducted the statistical analysis of the data with the numerical control software solution (www.ncss.com). we employed the repeated measures analysis of variance (anova) test to compare tests scores within the same patient group and the anova test to compare test's scores between the two groups (at similar phases of the study).

Eligibility criteria:
inclusion criteria: * histological diagnosis of early stage breast cancer * 18 years old or older exclusion criteria: * prior breast radiation * anemia * clinical depression * unable to sign informed consent
screening latent tuberculosis infection and observing preventive therapy in kidney transplantation

Conditions: Kidney Transplantation

Summary: study the prevalence of ltbi in patients who are waiting renal transplant and monitor the incidence of active tb

study the prevalence of ltbi in patients who are waiting renal transplant and monitor the incidence of active tb

Eligibility criteria:
inclusion criteria: 1. age between 20-65 and match one of below 2. waiting renal transplant or status post renal transplant 3. receiving long term dialysis exclusion criteria: 1. not agree to be enrolled 2. suspected active tb 3. hiv patients 4. viral hepatitis 5. using immunosuppressants within 3 months before enrollment 6. receiving lymphokine therapy 7. hemoglobin \< 8 g/dl 8. serum bilirubin \> 2.5 mg/dl 9. ast or alt \> 2 times of upper normal limit 10. lactation or pregnancy

Keywords: renal latent tuberculosis
forward and backward walking exercise on physical and cognitive functions

Conditions: Healthy Volunteers

Summary: to investigate the acute effects of forward and backward walking exercise on physical functions such as static and dynamic balance and cognitive functions such as attention, concentration, memory, processing speed, visual structuring skills, calculation and orientation.

this study is planned to investigate the acute effects of forward and backward walking on physical functions such as static and dynamic balance and cognitive functions such as attention, concentration, memory, processing speed, visual structuring skills, calculation and orientation. 50 healthy individuals were randomly divided into three groups for the study. the groups were divided into backward walking exercise group (gye) (n=17), forward walking exercise group (fwe) (n=16) and control group (cg)(n=17). before treatment for all three groups; sociodemographic and clinical data with the sociodemographic information form, physical activity levels with the international physical activity survey short form, pain severity with the visual analog scale (vas), fatigue levels with the borg scale, the person's selective attention capacity and skills, processing speed and general executive processing abilities. stroop test with tbag form to evaluate executive functions such as working memory, complex attention, planning and set shifting, with trail making test, evaluation of dynamic balance, neuromuscular control and movement asymmetries with y-balance test, static balance, postural stability evaluation on one leg it was evaluated with the standing test. the gye group completed a 25-minute backward walking exercise session, the fwe group completed a 25-minute forward walking exercise session, and the control group completed a 30-minute sitting rest between evaluation tests. after the exercises, there were significant differences in parameters such as attention, processing speed, concentration and maintenance of attention, working memory, planning, static and dynamic balance, and in the comparison between groups, significant differences were found in static balance and postural control (p\<0.05). it was observed that individuals in the backward walking group showed better improvements in some parameters after walking. however, these results need to be supported by future studies.

Eligibility criteria:
inclusion criteria: * to be between the ages of 18-25, * to be able to communicate verbally and in written turkish, * not complaining of pain in any part of the body during physical activity, * performing a normal walking pattern without compensatory movements. exclusion criteria: * participants participating in a routine exercise program * history of upper or lower extremity pathology or injury in the last 6 months * diagnosed neurological disease * diagnosed cognitive impairment * having a diagnosed orthopedic disease * using a walking aid * inadequate cardiovascular fitness * dyspnea on exertion * contraindication to walking * receiving medical treatment that causes imbalance.

Keywords: backward walking aerobic exercise cognitive functions
natural course of homocysteine after uneventful total joint arthroplasty

Conditions: Joint Prosthesis; Complications, Infection or Inflammation

Summary: the goal of this observational study is to asses the natural course of blood homocysteine levels in patients who underwent primary total joint arthroplasty surgery. the main question\[s\] it aims to answer are: * i̇s homocysteine a good marker for determining periprosthetic joint infection ? * i̇s homocysteine more sensitive marker for periprosthetic joint infections ?


Eligibility criteria:
inclusion criteria: * people who have undergone total knee arthroplasty operation * people who have undergone total hip arthroplasty operation exclusion criteria: * people who have undergone total knee arthroplasty operation and developed a periprosthetic joint infection * people who have undergone total hip arthroplasty operation and developed a periprosthetic joint infection

Keywords: periprosthetic joint infection diagnosis natural course total joint arthroplasty.
auditing of poor visual outcomes after un-eventual cataract surgery

Conditions: Cataract

Summary: globally, cataract is the major cause of blindness accounting for 51% of total blindness and there are regional variations in it. today, cataract surgery is a highly successful and cost-effective procedure, which enhances both the vision and quality of life of patients. visual acuity alone should not be used as a criterion for planning cataract surgery, since visual acuity and function do not necessarily correlate. therefore, there is a need to review our criteria for management. based on recent studies, at least 90% of the patients undergoing cataract surgery obtain a postoperative visual acuity of 6/12 or better in the absence of coexisting ocular pathology. a number of previous studies have looked at the effect of risk factors on visual outcomes following cataract surgery. risk factors commonly associated with worse visual outcomes include: age-related macular degeneration, diabetic retinopathy, corneal opacity/pathology, older age, female sex, previous vitrectomy, previous retinal detachment surgery, alpha-blockers, complex surgery, intraoperative complications and refractive surprise.


Eligibility criteria:
inclusion criteria: * patients with any type of cataract. exclusion criteria: * patients with diabetic retinopathy. * patients with previous ocular surgeries or pathologies. * patients with pre-operative visual acuity (no perception of light)
natural history study of serious medical events in pws

Conditions: Prader-Willi Syndrome

Summary: path for pws is a study to help researchers better understand serious medical events in pws over a 4-year period, as well as evaluate how pws-related behaviors change over time. the data from this study is intended to inform the development and clinical trial design of potential new treatments.

every 6 months, participants or their caregivers will be asked to update online surveys about medical problems and serious medical events, as well as provide information about conditions and behaviors often associated with pws such as hyperphagia. because this is an observational study, no study drug will be provided and no visits to a doctor or clinic are required.

Eligibility criteria:
inclusion criteria: participants must meet all of the following criteria: * confirmed diagnosis of pws * at least 5 years of age * live in the united states, canada, australia, or new zealand * must be enrolled or willing to enroll in the global pws registry (https://pwsregistry.org) participants or their caregiver must also meet all of the following criteria: * have access to the internet to complete online surveys at least every 6 months * agree to receive reminders to complete online surveys * allow the staff to ask questions about survey responses if more information is needed and to enter data into the surveys exclusion criteria: participants or their caregiver meeting any of the following criteria will be excluded: * is not able to read and understand english

Keywords: observational non-interventional prader-willi syndrome pws
assessing qbtest utility in adhd: a randomised controlled trial

Conditions: Attention Deficit Hyperactivity Disorder (ADHD)

Summary: attention deficit/hyperactivity disorder (adhd)is one of the most common mental health disorders of childhood. children with adhd often have poor attention, are restless and hyperactive and show impulsive behaviour. it is important to detect adhd so young people can have access to appropriate clinical interventions. one of the most common ways adhd is assessed is through the clinician's opinion; however, this can vary between clinicians and is thought to be one reason why adhd may be mis-diagnosed. using a more objective computer tasks may help improve our understanding of adhd. one computer task is the qbtest. the test presents different symbols to the child, and the child has to respond by pressing a button only when a target symbol appears. the test measures the child's attention, impulsivity and movement whilst doing this task. although the test is thought to be a valid measure, more research needs to be conducted on this measure to see whether it helps clinicians decision making. to see whether this test helps clinicians make a diagnosis of adhd and helps with medication decisions, children and young people will be asked to complete the task as part of their initial assessment for adhd. half the participants and their clinician will have access to the qbtest result; the other half will not have access to the qbtest result until the end of the study. participant's parents, teachers and the clinician will also be asked to complete some questionnaires about the child's symptoms and behaviour. if the child is diagnosed with adhd and is given medication they will be asked to complete the task again on medication. the same set of questionnaires will be completed by the parents/teachers/clinicians. the entire sample will be followed up at 6 months and asked to complete the questionnaires.


Eligibility criteria:
inclusion criteria: * age 6-17 years (may turn 18 years during the study). * referred to camhs or community paediatrics for an adhd assessment * capable of providing written informed consent (over 16) * parental consent (under 16) exclusion criteria: * non-fluent english * suspected moderate or severe learning disability * previous or current diagnosis of adhd

Keywords: adhd qb test activity attention children clinical decision making
community-based partnership's efficacy in decreasing injury rates at night in dallas, tx

Conditions: Blood Alcohol Concentration; Drunk Driving

Summary: according to the centers for disease control and prevention (cdc), "88,000 people die every year due to alcohol-related issues including homicide, sexual assault, intimate partner violence, and suicide". in the city of dallas, violent crimes have decreased by roughly 4% in 2022 compared to 2021. dallas police department (dpd) implemented changes in may 2021 to combat violent crimes.

to address these issues, 24hour dallas, a community-based non-profit organization, has utilized public health approaches at the business and city level. their overarching goals are to reduce drunk driving, violence against women, human trafficking, and general violence or injuries related to alcohol use, all within the nighttime hours of 6pm and 6am through the application of their good neighbor initiative and copper star certification for businesses. both the good neighbor initiative and the copper star certification follow a model from safe night llc, an organization that was built on the premise of the arlington restaurant initiative in arlington, virginia.

Eligibility criteria:
inclusion criteria: * • chief complaint or diagnosis associated with a trauma mechanism of injury: assault (i.e., gunshot wounds, knife wounds, general assault, or sexual assault), mvc, motorcycle/all-terrain vehicle collision (mcc), or auto-ped/bicycle collision * injury occurred between 6pm-6am * injury occurred in city of dallas, tx exclusion criteria: * • injuries from mechanism other than assault, mvc, mcc, or auto-ped/bicycle * assault occurs outside of 6pm-6am window * assault occurred outside of dallas city limits
a pilot study to evaluate optical spectroscopy of pigmented skin lesions

Conditions: Skin Cancer

Summary: the incidence of malignant melanoma has increased dramatically in recent decades. in 1930, the lifetime risk of an individual in the united states developing melanoma was 1 in 1,500. this has been exponentially increasing over the years with the risk estimated to be 1 in 75 in 2000 . according to the american cancer society, approximately 59,580 new cases of melanoma will be diagnosed in the united states in 2005 and about 7,770 people are expected to die of the disease.

the researcher ucan use special imaging devices to obtain information about a typical mole and melanoma and use this information to determine the different between malignant and benign melanized lesions. the imaging devices are, modified two layer diffuse optical spectroscopy,multi-spectral imaging, and spatially modulated quantitative spectroscopy can use to measure atypical moles and melanoma and correlate the results of the biopsy tissue histology. the imaging devices can quantify melanin, oxy and deoxy hemoglobin concentration, water, lipid and reduced scattering coefficients and can compare results to histopathologic. atypical moles and melanoma have a different optical profile based on physiological parameters compared to benign nevus.

Eligibility criteria:
inclusion criteria: * 18 years or older. * have atypical mole/s and melanoma exclusion criteria: * age less than 18 years old. * have no atypical mole/s and melanoma

Keywords: moles melanoma
a phase ii study in patients with alopecia areata

Conditions: Alopecia Areata

Summary: this is a global phase 2 study to evaluate the safety and effectiveness of an investigational study drug (called shr0302) in adults with moderate to severe alopecia areata.

the study is placebo-controlled, meaning that some patients entering the study will not receive active study drug but will receive tablets with no active ingredients (a placebo). this is a dose-ranging study, investigating 3 different dosing regimens. it will be double-blinded, meaning that the sponsor, the study doctors, the staff, and the patients will not know whether a patient is on active study drug (or the dose) or placebo.

Eligibility criteria:
inclusion criteria: * male or female subjects between 18-65 years of age (both inclusive), at the time of informed consent; * must have moderate to severe alopecia areata. exclusion criteria: * other types of alopecia or other diseases that can cause hair loss * other scalp diseases that could interfere with assessment of hair loss/regrowth * any previous use of any janus kinase (jak) inhibitor
arthroscopic rotator cuff repair with uc-mscs for large to massive tears

Conditions: Rotator Cuff Disease

Summary: safety analysis of allogeneic umbilical cord-derived mesenchymal stem cells in patients undergoing rotator cuff repair for massive or large rotator cuff tears


Eligibility criteria:
inclusion criteria: * male or female 19 years of age and older * unilateral shoulder pain with a pain score of 4 or higher. * patients with a symptom duration of at least three months who have not responded to conventional treatments, including analgesics. * patients diagnosed with massive or extensive full-thickness rotator cuff tears confirmed by computed tomography arthrography or magnetic resonance imaging. exclusion criteria: * patients diagnosed with small or medium full-thickness rotator cuff tears among study participants with full-thickness rotator cuff tears. * patients who have received subacromial injection therapy in the affected shoulder within the past three months. * patients who have undergone rotator cuff surgery on the affected shoulder within the past six months. * patients exhibiting or suspected of having the following radiological findings: malignant tumors, severe glenohumeral osteoarthritis, or bony abnormalities causing subacromial space narrowing. * patients presenting with symptomatic cervical spine disorders. * patients experiencing bilateral shoulder pain. * patients diagnosed with multiple arthritis, infectious arthritis, rheumatoid arthritis, or fibromyalgia. * patients with neurological deficits. * pregnant or breastfeeding patients * patients unwilling to use effective contraception during the study period. * patients currently infected with hbv, hcv, or hiv, or those with a positive rpr test result. * patients with severe conditions that may affect the study, including cardiovascular diseases, renal diseases, hepatic diseases, endocrine disorders, or malignancies. * patients who are unable to comprehend the questionnaires used for study assessments, including the visual analog scale (vas), or those with communication difficulties due to psychiatric disorders. * any other cases deemed inappropriate for study participation by the investigator.
prospective, international, multicenter, observational study to evaluate the clinical performance and safety of a silicone-coated transparent postoperative dressing

Conditions: Wounds and Injuries; Skin Diseases

Summary: although, a huge number of acute wounds is treated successfully every year, health care professionals (hcps) are facing more and more problems when treating skin damages or surgical incisions: the number of patients with fragile and/or sensitive skin is highly increasing. such patients are having a skin integrity issue, meaning the skin is vulnerable to injury, often damaged, or unable to heal. the investigational medical devices (imds) of the planned clinical evaluation, leukomed® t skin sensitive and leukomed® t plus skin sensitive have been developed for treatment of acute wounds on patients with fragile or sensitive skin to provide a reliable but skin-friendly fixation and wound care option. the primary purpose of this clinical study is the evaluation of clinical performance to stay in place up to seven days and the safety of both dressings. further, data on wearing comfort, product handling, pain during removal and quality of life are considered as secondary outcomes. the products will be used as part of routine wound care within the scope of their intended purpose without any additional invasive or burdensome examination.


Eligibility criteria:
inclusion criteria: * men, women or diverse * ≥ 65 years of age * patient is mentally and physically able to participate in this study * signed informed consent to participate in this study * fragile skin condition * acute wound (surgical wound or laceration), indicated for treatment with the investigational products for a time period of 7 days exclusion criteria: * infection of the target wound * alcohol or drug addiction * known sensitivity or allergy to any component of the study product * patients who participate in any other clinical study investigating drugs or medical devices
comparison of erector spina plane block and lumbar plexus block in femoral fracture surgery

Conditions: Femur Fracture; Erector Spinae; Lumbar Plexus; Ultrasound Guide

Summary: the aim is to clinical trials compare the lumbar plexus block method with the erector spinae plan block method in terms of analgesic efficacy and possible complications. i̇n patients for femur fracture surgery. the main questions it aims to answer are: 1. is erector spinae plane block as effective as lumbar plexus block for postoperative analgesia in femur fractures? 2. is erector spinae plane block effective for reducing opioid consumption compared to lumbar plexus block?


Eligibility criteria:
inclusion criteria: * proximal femoral surgery * all patients who can respond to pain assessment questions exclusion criteria: * regional block contraindications, * severe cardiac and respiratory disease, * severe coagulopathy, * body mass index greater than 35