Kornimate/medical-research-clean huggingface dataset:
feasibility study on the characterization of the immune profile of young patients after treatment for breast cancer

Conditions: Breast Cancer

Summary: this study aim to determine kinetic of post treatment recovery/variation of a panel of innate and adaptative immune system cells and molecules. the results should allow to determine the optimal post treatment immunomonitoring timing and panel to be used for future studies.

there is a complexe interaction between tumor cells ans host immunity. immunity system (is) is clearly involved in cancer developement control, and it is suggested that it could participate to the response to anti cancer treatment. there is however no validated immunomonitoring strategy to allow a reliable patient's immune status along time, and particularly after treatment.there are scarce existing information on immunologic reconstitution profile recovery after treatment. this study aim to perform immunomonitoring in young patients with cancer to describe kinetic of recovery/variation of a panel of innate and adaptative immune system cells and molecules, selected by their potential relevance according to literature. the concerned population are young women (˂40 yo) with breast cancer. there will be 2 patients cohorts a or "end of treatment" : patients recruited at the end of treatment (study cohort) b or "diagnosis" : patients recruited at diagnosis (reference values) this study should contribute to give sufficient data to determine the pertinent timing and cells/molecules panel to evaluate immunity profiling after treatment. these results could be used for further studies.

Eligibility criteria:
inclusion criteria: * women with breast cancer at initial diagnosis or at the end of treatment * chemotherapy planned or performed in the treatment plan * patient not opposed to participate to the present study * affiliated to a french social security scheme. exclusion criteria: * metastatic breast cancer * pregnant or breastfeeding woman * treatment with monoclonal antibodies or immunotherapy * immunosuppressive therapy * thymus irradiation * chronic infection in progress * inborn or acquired disease (other than breast cancer) impacting the immune system (saa, lupus...) * subject under guardianship or deprived of liberty

Keywords: immunity recovery post treatment
is it really necessary to insert a nephrostomy tube or double j stent in percutaneous nephrolithotomy?

Conditions: Kidney Calculi; Postoperative Pain

Summary: in this study, investigators aimed to compare the postoperative pain status and comfort situations depending on instruments used in the percutaneous nephrolithotomy operation

a total of 90 patients aged 18 and over will undergo percutaneous nephrolithotomy (pnl) for kidney stones of 2 cm or more between 01/08/2023 and 01/02/2024 will be included in the study. preoperative demographic data of the patients, body mass index (bmi), stone size and stone location, hemogram, biochemistry, coagulation parameters, urine analysis, and urine culture test results will be recorded. radiological evaluation will be obtained according to computerized tomography (ct) data. while patients aged 18 years and above with kidney stones larger than 2 cm were included in the study, patients under 18 years of age, patients with anatomical anomalies (horseshoe kidney, ectopic kidney, ureteropelvic junction stenosis, ureteral stenosis), patients with uncorrectable bleeding diathesis, bilateral kidney stones will not be included in the study. patients who do not have major complications (serious bleeding, renal pelvis perforation) after the pnl procedure and residual stones cannot be detected according to the scopic image obtained will be randomized and divided into three groups. patients in the first group will not be fitted with a double j (jj) stent and/or nephrostomy (completely tubeless), patients in the second group will only be fitted with a jj stent, and patients in the third group will only be fitted with a 14 french malecot nephrostomy. the patients' pain scores, analgesic use, hemoglobin values, operation success, complications, and additional procedure requirements in the postoperative period will be compared.

Eligibility criteria:
inclusion criteria: * patients aged 18 years and above * larger than 2 cm kidney stones exclusion criteria: * under 18 years of age * anatomical anomalies (horseshoe kidney, ectopic kidney, ureteropelvic junction stenosis, ureteral stenosis), * uncorrectable bleeding diathesis * bilateral kidney stones

Keywords: percutaneous nephrolithotomy nephrostomy tube double j stent
influence of lung ultrasonography on the prognosis and postoperative outcomes in cardiac surgical patients

Conditions: Ischemic Heart Disease; Aortic Stenosis, Severe; Aortic Insufficiency; Mitral Stenosis; Mitral Insufficiency; Mitral Stenosis with Insufficiency; Tricuspid Insufficiency; Ascending Aortic Aneurysm

Summary: the goal of this interventional is to assess advantages of the ultrasound examination of the lungs in the early postoperative period in cardiac surgical patients after heart surgeries requiring cardiopulmonary bypass. evaluation of pulmonary complications and outcomes during mid-term follow-up, as well as comparison of ultrasound examination and traditional roentgenologic methods (x-ray examination and ct of the chest) will be performed. the main question\[s\] it aims to answer are: * is ultrasound examination of the lungs a more specific and sensitive method in identification of early postoperative pulmonary complications after on-pump cardiac surgical procedures, in comparison with traditional x-ray methods. * does early identification of interstitial pulmonary edema (based on number of visualised b-lines in the early postoperative period), influences mid-term outcomes in this cohort of patients participants will undergo ultrasound examination of the lungs on postoperative day 1, 3, 5 and 7 after heart surgery. based on ultrasound findings and degree of interstitial pulmonary edema, medical (diuretics, anti-inflammatory, e.t.c) therapy will be modified. researchers will compare this group of patients with control group, in which ultrasound examination will be performed in the same time frames, but no changes in medical management based on ultrasound findings will be made to see if timely administered medical therapy, based on ultrasound findings, can significantly improve symptoms, hospital lengths of stay and outcomes of this patients.


Eligibility criteria:
inclusion criteria: * open heart surgery with cardiopulmonary bypass (cpb) between 15 december 2023 and 15 december 2024 * signed informed consent for participation in the study exclusion criteria: * reoperations on the open heart with cpb * surgical procedures on lungs and lung cancer in the anamnesis * chronic obstructive pulmonary disease, stage iii * chronic kidney disease, stages 4 and 5 * patients with low risk score profile by the society of thoracic surgeons

Keywords: ultrasound examination of the lungs b-lines coronary artery bypass grafting heart valve surgery cardiopulmonary bypass on-pump cardiac surgery
multi-media e-book for second-trimester termination due to fetal anomaly

Conditions: Termination of Pregnancy

Summary: the subjects of this study are married couples who received termination of pregnancy, the main purpose is to explore the effectiveness of the e-book education model. outcome indicators include anxiety, depression, and grief, as well as the satisfaction of the education.

1. study design: the study subjects were couples of obstetric inpatients who would receive termination of pregnancy. both groups were assessed by the obstetrician in the outpatient clinic who must be admitted to the hospital to terminate the pregnancy. after receiving consent, a pre-test is performed in the clinic. the pre-test included questionnaires (basic attribute, state-trait anxiety inventory (stai) - the state anxiety scale (s-anxiety), perinatal grief scale (pgs), beck depression inventory). after complete pre-teat, study nurse will provide the experimental group a qr code to enter the cloud system (hama star e-book network platform), enable the couples to read the content at home; the control group receives traditional oral instructions. when the experimental group entered the delivery room, the researcher used the hama star e-book network platform to play the content of the termination of pregnancy e-book education model, and discussed the content with them; the control group receives regular traditional education model, with booklet and oral instructions, the intervention is about 20-25 minutes. the experimental group is able to use e-books as needed during induction, hospitalization, and after discharge. two post-tests are conducted for follow-up. both groups write the first post-test questionnaire (state-trait anxiety inventory (stai) - the state anxiety scale (s-anxiety), perinatal grief scale (pgs), beck depression inventory) 60 minutes after education. then, complete the second post-test questionnaire at the next appointment a month after. 2. randomization process: this study used a two-group pre- and post-test mode in experimental design, and random allocation to assign subjects into experimental and control groups. participants were randomly allocated to the experimental or control group in a 1:1 ratio using the network randomization tool (www.randomizer.org/). 3. sample size calculation:g-power version 3.1 was used to calculate the required sample size for the study. set power 0.8, α = 0.05, based on the effectiveness (effect 0.30), the number of samples required for each group in this study is 32, because the tracking period is up to half a year, with a loss rate 50%, the two groups need a total of 96 participants.

Eligibility criteria:
inclusion criteria: 1. at least 20 years old 2. consciousness clear and capable of complete the questionnaires 3. able to communicate in mandarin or taiwanese 4. agree to participate in the study and sign the consent exclusion criteria: 1. emergency admissions for induction. 2. non-medical reasons and pay own expenses to terminate the pregnancy 3. have psychiatric illness history or other disorders that affect cognitive function

Keywords: termination fetal anomaly gender grief nursing e-book
heat shock protein (hsp) 70 to quantify and characterize circulating tumor cells

Conditions: Melanoma Stage IV; Sarcoma; Squamous Cell Carcinoma; Pancreatic Cancer Stage IV; Prostate Cancer; Breast Cancer Stage IV

Summary: this study investigates the ability of heat shock protein hsp70 to isolate and quantify circulating tumor cells (ctcs) in patients with advanced or metastatic tumors. ctcs will be isolated from peripheral blood before antineoplastic treatment and again after three months. isolation using hsp70 will be compared with standard ctc isolation by epcam. additionally, imaging parameters of the primary tumor (if available) and metastases will be analysed and correlations between molecular alterations and imaging parameters will be assesed.


Eligibility criteria:
inclusion criteria: * metastatic malignant melanoma (stage iv) * metastatic or unresectable pancreatic adenocarcinoma (stage iii or iv) * metastatic breast cancer * metastatic sarcoma * metastatic squamous cell carcinoma of the cervix uteri, head and neck region, vulva, anus or penis * hormone-refractory prostate cancer exclusion criteria: * psychiatric disorders that impede adequate informed consent
extracorporeal co2 removal in hypercapnic patients

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: noninvasive ventilation represents the standard of care for patients with exacerbation of chronic obstructive pulmonary disease. however, niv fails in almost 30% of the most severe forms of acute hypercapnic respiratory failure and patients must undergo endotracheal intubation and invasive ventilation to restore adequate gas exchange. under these circumstances, patients may express a clear intention not to be intubated.the aim of this study is to retrospectively assess efficacy and safety of noninvasive ventilation- plus-extracorporeal co2 removal in patients who fail niv and refuse endotracheal intubation.

during a period of two years (from january 2013 to july 2015) 35 patients with acute hypercapnic respiratory failure due to exacerbation of chronic obstructive pulmonary disease, refused endotracheal intubation after failing niv and were treated with extracorporeal co2 removal plus niv as last resort therapy. the collected data of these patients will be retrospectively matched with data obtained from 35 historical controls who received conventional treatment with endotracheal intubation. the study will retrospectively compare intubation rate, acid base homeostasis, norepinephrine requirements (in the patients who due to clinical conditions were under norepinephrine before starting extracorporeal co2 removal ) and coagulation parameters.

Eligibility criteria:
inclusion criteria: * exacerbation of chronic obstructive pulmonary disease * failure of non invasive ventilation * expression of a clear intention not to be intubated exclusion criteria: * alterations in mental status which do not allow to express a clear intention not to be intubated * contraindications to anticoagulation
long covid-19 intervention using digital health & technology

Conditions: Long COVID; Distress Tolerance

Summary: the current study seeks to pilot test the iendure (enhancing distress tolerance to uplift motivation in recovery) intervention among 10 participants with long covid (coronavirus disease) symptoms. following informed consent procedures, participants will complete a brief baseline assessment of self-report measures. participants will then engage in the iendure intervention (described below) for 4 weeks. at the end of the intervention period, participants will complete another brief assessment of self-report measures and a qualitative interview about their experience with the program. participants will be compensated for completing the baseline and post-intervention assessments


Eligibility criteria:
inclusion criteria: * must be over 18 years of age * must speak english proficiently * must own a text-enabled device * diagnosis (self-reported) of covid-19 * diagnosis (self-reported) of long-covid symptom(s) * must be able to provide written, informed consent exclusion criteria: * not fluent in english * limited mental capacity or inability to provide informed written consent
the caregiver pathway - an intervention to support caregivers of critically ill patients

Conditions: Caregiver Stress Syndrome

Summary: the aim of the project is to test the efficacy of a systematic intervention for individual follow-up of caregivers at the intensive care unit during a 12 month randomized controlled trial.

caregivers of patients admitted to an intensive care unit (icu) often experience the situation as traumatic and stressful. long term consequences such as fatigue, anxiety, depression and symptoms of post-traumatic stress are reported among 30-50 percent of the caregivers of critically ill patients. the need for supportive interventions is called for. the overall goal of this project is to improve the support for caregivers of intensive care patients. a systematic intervention for individual support of caregivers, the caregiver pathway intervention, has been developed with a multidisciplinary approach, based on existing evidence, through interviews with former caregivers, workshops with health care personnel and user input and testing. the intervention consist of mapping of caregivers' prioritized symptoms, needs and preferences with a digital assessment tool, followed by a meeting with a nurse to address these issues, a structured conversation at discharge, and an invitation to a follow-up conversation 4-6 weeks after discharge/patients death. the aim of the project is to test the efficacy of the caregiver pathway intervention among caregivers at the icu in a randomized controlled trial, using outcome measures such as symptoms of post-traumatic stress, anxiety/depression, cost-utility measures and health-related quality of life. the participants will be randomly assigned to the caregiver pathway intervention or the follow-up as usual group. both groups will receive outcome measures at baseline and at 3, 6 and 12 months.

Eligibility criteria:
inclusion criteria: * caregivers of patients admitted to the intensive care unit that is expected to receive invasive mechanical ventilation for at least 48 hours * between 18 and 70 years old * able to understand and speak norwegian exclusion criteria: • none

Keywords: caregivers post traumatic stress health related quality of life intensive care
pheochromocytoma and hemodynamic instability

Conditions: Pheochromocytoma; Hypertension; Surgery

Summary: the aims of our study were to define perioperative hi during laparoscopic adrenalectomy for pheochromocytoma, assess the incidence of perioperative hi, and identify predictive factors of perioperative hi in our group of patients.

the study was a retrospective observation of consecutive patients with histologically confirmed pheochromocytoma undergoing laparoscopic adrenalectomy between years 2003 and 2019.

Eligibility criteria:
inclusion criteria: * patients with histologically confirmed pheochromocytoma undergoing laparoscopic adrenalectomy exclusion criteria: * bilateral tumour * no histopathological result * neoplastic spread

Keywords: pheochromocytoma laparoscopy haemodynamics surgery
pews implementation in an lmic setting

Conditions: Oncology

Summary: the pews implementation study will be undertaken with the following objectives: 1. assess the effectiveness of implementation of pews and resuscitation training to identify patients at risk for clinical deterioration and to impact the frequency of clinical interventions made by treating providers on these patients. 2. assess the effectiveness of implementation of pews and resuscitation training to impact time sensitive clinical interventions made on patients at risk for clinical deterioration. 3. assess the impact of implementation of pews and resuscitation training on length of stay for patients admitted to the pediatric oncology ward.


Eligibility criteria:
inclusion criteria: * patients eligible for the study are defined as pediatric patients (between birth and 12 years of age) admitted and subsequently discharged from the pediatric oncology ward in beit jala, palestine and gaza city, palestine between march 2019 to june 2020 exclusion criteria: * patients will be excluded if they are not admitted to inpatient status. no oncology outpatients such as those in the infusion program will be included.
touch on one thumb, rsi on the other thumb: which surgery shows better results

Conditions: Osteoarthritis Thumb; Joint Diseases; Musculoskeletal Diseases or Conditions; Osteoarthritis; Arthrosis of First Carpometacarpal Joint

Summary: the study aims to determine whether cmc i arthroplasty using a touch® implant results in higher patient satisfaction compared to rsi arthroplasty in the medium-term in patients with primary thumb osteoarthritis. additionally, the study compares the patients' clinical and self-reported outcomes between the touch® implant and the rsi arthroplasty. therefore, patients with a touch® implant in one thumb and an rsi arthroplasty in the other thumb will be recruited.

patients suffering from osteoarthritis in the first carpometacarpal joint (cmc i oa) are often surgically treated with a resection-suspension-interposition (rsi) arthroplasty. an alternative technique is an arthroplasty with a touch® implant. there is a growing body of evidence indicating that patients with a touch® prosthesis recover significantly faster and return to work more quickly than patients after an rsi arthroplasty. however, there have been no studies comparing the two operations in the same patient. by recruiting patients with a touch® implant in one thumb and an rsi arthroplasty in the other thumb, this study aims to investigate whether cmc i arthroplasty using a touch® implant leads to higher patient satisfaction compared to rsi arthroplasty in the medium-term. further patient-reported and clinical outcomes will be assessed to compare the two surgeries.

Eligibility criteria:
inclusion criteria: * informed consent signed by the patient. * patient is diagnosed with primary oa in both cmc i joints and was operated with a touch® prosthesis on one thumb and with an rsi arthroplasty on the other thumb. exclusion criteria: * patient with any type of revision surgery at the cmc i joint * patient underwent hand surgery within the last three months * legal incompetence

Keywords: touch® prothesis rsi resection-suspension-interposition arthroplasty thumb carpometacarpal joint dual mobility prosthesis
stratagraft® skin tissue in the promotion of autologous skin regeneration of complex skin defects due to thermal burns that contain intact dermal elements

Conditions: Burn, Thermal

Summary: about 70 participants will be enrolled. they will have complex skin defects because of burns caused by heat. the burns will: * be on 3-49% of the participant's total body surface area (tbsa) * require surgery for skin replacement * include intact dermal elements the burns are called deep, partial-thickness thermal burns because the skin was damaged by heat but still has some dermis that was not damaged. the dermis is the layer of skin under the outer layer (epidermis). it is the thickest layer of the skin that provides strength and flexibility to the skin. all patients will receive both treatments, but on different areas of their burns. their wounds will not be compared to other patients. one treatment area on their own body will be compared to the other one. this will help to find out if stratagraft is safe and effective for deep partial thickness burns. it will also see if stratagraft might help healing enough to use it instead of the patient's own healthy skin to repair the damage.


Eligibility criteria:
inclusion criteria subject-specific criteria: 1. men and women aged ≥ 18 years 2. written informed consent 3. sufficient healthy skin identified and reserved as a donor site in the event that the stratagraft treatment site requires autografting 4. clinical expectation that the study donor site will heal without grafting 5. complex skin defects of 3-49% tbsa * total burn may consist of more than one area treatment site-specific criteria: 6. thermal burn(s) with intact dermal elements for which excision and autografting are clinically indicated 7. total of both study treatment areas can be up to 2000 cm2 8. first excision and grafting of study treatment sites 9. thermal burn(s) on the torso, arms, or legs exclusion criteria subject-specific criteria: 1. pregnant women 2. prisoners 3. subjects receiving systemic immunosuppressive therapy 4. subjects with a known history of malignancy 5. preadmission insulin-dependent diabetic subjects 6. subjects with concurrent conditions that in the opinion of the investigator may compromise subject safety or study objectives 7. expected survival of less than three months 8. participation in the treatment group of an interventional study within 90 days prior to enrollment treatment site-specific criteria: 9. full-thickness burns 10. chronic wounds 11. the face, head, neck, hands, feet, buttocks, and area over joints 12. treatment sites immediately adjacent to unexcised eschar 13. clinical or laboratory determination of infection at the anticipated treatment sites

Keywords: trauma-related wound deep partial thickness skin wound