Kornimate/medical-research-clean huggingface dataset:
alendronate to prevent loss of bronchoprotection in asthma

Conditions: Asthma

Summary: beta-2-agonists are effective in reducing airway narrowing in asthma and protecting against stimuli that produce bronchoconstriction. the combination of long-acting beta agonists (laba) and inhaled corticosteroids (ics) has become the most commonly used asthma controller medication class in the united states, but unfortunately, even when labas are added to ics and used regularly, 58-81% of patients with asthma fail to achieve total control. regular use of beta-agonists, both short and long-acting, reduces the ability of these agents to protect against the airway narrowing that occurs in asthma in response to bronchoconstrictor stimuli. we refer to this reduced effect as loss of bronchoprotection. in this proof of concept trial we aim to determine if alendronate, which diminishes beta-2 adrenergic receptor internalization, can reduce the loss of bronchoprotection that occurs with regular use of labas, even when used in combination with ics.


Eligibility criteria:
inclusion criteria: * clinical history consistent with moderate asthma for \>1 year * asthma is controlled with ics, with an fp dose ≤ 1000mcg/day and \>100mcg/day (or equivalent) * able to perform reproducible spirometry according to ats criteria * baseline fev1 ≥ 50% of predicted and ≥1l. * if fev1 \<80%, a minimum 12% increase in fev1 post-bronchodilator or a mch pc20 ≤ 8 mg/ml * if fev1 ≥80%, a mch pc20 ≤ 8 mg/ml * salmeterol protected mch ≤ 16 mg/ml exclusion criteria: * uncontrolled asthma, as suggested by an act score \ 500mcg or equivalent) * non-ics controller medication or laba use within 4 weeks of study entry. * contraindications to use of bisphosphonates: history of intolerance to bisphosphonates, history of esophageal ulcers, history of hematemesis, uncontrolled gastro-esophageal reflux disease, inability to stay erect for 30 minutes after oral drug, history of osteonecrosis of the jaw, dental extraction or root canal in prior 8 weeks, or anticipated during the study * calculated gfr of less than 35 ml/min * history of smoking (cigarettes, cigars, pipes, marijuana or any other substances) within the past 1 year, or \> 10 pack-years total if ≥ 18 years of age * systemic corticosteroid treatment for any condition within 4 weeks of enrollment at visit 1, history of significant asthma exacerbation requiring systemic corticosteroids within 4 weeks of visit 1 or more than five courses of systemic corticosteroids in the past year, history of a life-threatening asthma exacerbation requiring intubation, mechanical ventilation, or resulting in a hypoxic seizure within the last 2 years * history of a respiratory tract infection within 4 weeks of visit 1 * receiving hyposensitization therapy other than an established maintenance regimen defined as a continuous regimen for ≥ 3 months prior to enrollment
evaluation of skeletal muscle function using ultrasonic elastography

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the goal of observational study is to evaluation of skeletal muscle function in patients with chronic obstructive pulmonary disease before and after lung rehabilitation training using ultrasonic elastography in chronic obstructive pulmonary disease. the main question it aims to answer are:evaluation of skeletal muscle function in patients with chronic obstructive pulmonary disease before and after lung rehabilitation training using ultrasonic elastography. participants will undergo pulmonary rehabilitation.


Eligibility criteria:
inclusion criteria: * the age is between 40-80 years old * patients with chronic obstructive pulmonary disease who meet the diagnostic criteria of gold guideline(2019) * there was no acute exacerbation in the past 12 weeks exclusion criteria: * hypoxemia (oxygen partial pressure is less than 60mmhg or oxygen saturation is less than 88% at rest), or patients who need continuous oxygen inhalation, or patients with any contraindication to exercise test (refer to the american thoracic association/american association of thoracic physicians exercise test guidelines) * oral glucocorticoids * receive long-term oxygen therapy prescription * have participated in supervised exercise programs in the past 12 months * history of other lung diseases, including pneumoconiosis, bronchiectasis, tuberculosis, primary pulmonary hypertension, pulmonary embolism, interstitial lung disease * diseases that restrict the active exercise ability of participants or involve skeletal, neuromuscular, cardiovascular or metabolic disorders of muscle activity, such as tumors, diabetes, muscle weakness, etc
non contrast mri in lower extremity

Conditions: Venous Insufficiency of Leg; Venous Leg Ulcer; Venous Occlusion; Contrast Media Reaction

Summary: we collected retrospectively the non contrast mri in chia yi memorial hospital for different venous disease of lower extremity morphology and flow ananlysis were done.

retrospective, analysis of the venous figure by trance mri no drug/contrast median usage no radiation toxicity the range from the pelvic to the toe

Eligibility criteria:
inclusion criteria: * possible venous disease no contraindication for mri exclusion criteria: * could not tolerate mri packemaker

Keywords: mri, cvs contrast reflux ablation
pupillometry for pain assessment in critically ill patients

Conditions: Acute Pain

Summary: this study was part of a quality improvement project at the department of anesthesiology and intensive care medicine, charité - universitaetsmedizin berlin. being in pain is reported to be one of the most important stressors in critically ill patients and worsens outcome. the evaluation of pain using validated scores in patients who are able to self-report significantly improves the quality of analgesic therapy and health related outcomes in intensive care patients. however, behavioral pain score that are used in sedated or delirious patients, often underestimate the severity of pain. the primary aim of this study is to investigate if measurement of the pupillary light reflex amplitude correlates with the results of pain assessment using validated pain scores in critically ill patients.


Eligibility criteria:
inclusion criteria: * critically ill patients * aged 18 years or older * patients with an expected intensive care unit length of stay of of at least 48 hours. exclusion criteria: * not german speaking * traumatic brain injury * stroke * increased intracranial pressure * ocular disease or surgery.
high flow nasal cannula in comparison with nasal continuous positive airway pressure in the management of respiratory distress syndrome

Conditions: Respiratory Distress Syndrome

Summary: to compare the primary outcome, failure of extubation defined by the need for re-intubation and mechanical ventilation within 5 days of initial extubation and secondary outcomes, morbidities and mortality after using of heated humidity high flow nasal cannula (hhhfnc) and nasal continuous positive airway pressure (ncpap) in the immediate post-extubation period for preterm infants between 24 and 28 weeks gestation with respiratory distress syndrome.

inclusion criteria were: 1) preterm neonates with gestational age of 24 to 28 completed weeks. 2) in the case of twins, both neonates were included in the same treatment arm. 3) success to wean with 24 hours to extubate. 4) parental written informed consent for participation in the study obtained on admission into the hospital or prior to delivery. exclusion criteria were: 1) evidence of severe birth asphyxia. 2) known genetic or chromosomal disorders. 3) infants delivered to mothers with ruptured membranes of more than three weeks duration. 4) potentially life-threatening conditions unrelated to prematurity. 5) participation in another clinical trial of any placebo, drug, biological, or device conducted under the provisions of a protocol. randomization a computer-generated block-randomization sequence with random block sizes was used. infants who were part of multiple births underwent individual randomization. clinicians opened consecutively numbered, sealed, brown envelopes immediately before extubation to determine the study-group assignment.

Eligibility criteria:
inclusion criteria: 1. preterm neonates with gestational age of 24 to 28 completed weeks. 2. in the case of twins, both neonates were included in the same treatment arm. 3. success to wean with 24 hours to extubate. 4. parental written informed consent for participation in the study obtained on admission into the hospital or prior to delivery. exclusion criteria: 1. evidence of severe birth asphyxia. 2. known genetic or chromosomal disorders. 3. infants delivered to mothers with ruptured membranes of more than three weeks duration. 4. potentially life-threatening conditions unrelated to prematurity. 5. participation in another clinical trial of any placebo, drug, biological, or device conducted under the provisions of a protocol.

Keywords: cpap hhhfnc rds elbw
comparing two different approaches in robotic-assisted renal surgery

Conditions: Renal Tumor

Summary: the purpose of this study is to determine if the novel tr approach is superior to the standard rp approach. the anticipated study outcome is a time saving of at least 30% from first skin incision to detection of the renal artery compared to the conventional rp approach, and also a better workspace perception by the operating surgeon.

the trans abdominal approach (ta) for total and partial nephrectomy (pn) has been widely adopted due to the easy trocar placement and the good working space. the retroperitoneal approach (rp) has gained popularity because the renal artery is often found fast and the operation remains in an anatomically separated space, making it preferable, especially for patients who underwent abdominal surgery in the past. however, both approaches face difficulties. trocar placement for rp can be challenging, and the working space often is limited, while ta is impaired in cases of dorsal tumors and dissection of the renal artery can be challenging due to the anatomic localization dorsally to the renal vein. up until now, no direct systematically and prospective comparison of these two approaches was performed. the overall objective of this trial is to assess if the novel tr approach is superior to the conventional rp approach in performing robotic assisted (partial) nephrectomy. to date, no systematic, prospective, randomised study has been conducted on this topic and described in the literature.

Eligibility criteria:
inclusion criteria: * age 18 years or older * patient with a renal tumor or non-functionally kidney that is a candidate for robotic assisted surgery (ras) nephrectomy or partial nephrectomy (pn) * informed consent as documented by signature (appendix informed consent form) exclusion criteria: * renal vein tumor thrombus * pregnancy or suspected pregnancy

Keywords: robotic surgery renal tumor
chronic widespread pain

Conditions: Chronic Pain

Summary: cognitive-behavioral treatments have proven effective in helping people with chronic pain. however, due to the limited availability of trained clinicians, many young people with chronic pain problems do not benefit from them. in order to overcome the shortage of clinicians researchers have begun to develop treatment programs that could be self-administered by smartphones. although this is a step in the right direction, it is equally true that it also encloses a problematic issue. namely, a large number of experienced clinicians would still be needed to oversee the functioning of these programs, and it does not seem likely that they will be available within a short time, at least in certain countries. the objectives of this project are (1) to develop a web platform (ipains) to assist the clinician in the process of (a) creating and (b) administering cognitive-behavioral treatments for the management of chronic pain in adolescents and young adults, and (2) study the efficacy of a self-administered cognitive-behavioral treatment for young people with fibromyalgia or chronic widespread pain, developed and administered through ipains.

ipains, will be a computer assisted device made to help create cognitive-behavioral treatment programs (and manage them) that can assist novice or expert professionals in the management of chronic pain in youths (experts who otherwise would not have the resources to develop and manage treatments via smartphones). therefore, it will help in the process of knowledge translation in this understudied and undertreated problem (of chronic pain in youths). this platform (which includes an editor and administrator of treatments) will be evaluated in a sequential phased approach, consisting of 5 independent studies: (1) development of the tool and its contents (ie, digital objects of treatment), and (2) the web environment that allows creating and editing clinical treatments, (3) usability testing of ipains by a group of novice clinicians, and (4) experts clinicians to refine the prototype, and (5) a pilot study to determine the feasibility and effectiveness of the tool, that is, implementing a cognitive-behavioral self-administered treatment -through ipains- with patients with fibromyalgia or chronic widespread pain (fibroline).

Eligibility criteria:
inclusion criteria: * diagnosis of fibromyalgia or chronic widespread pain * capable of understanding, reading and writing in spanish exclusion criteria: * physical disabilities that interfered in the use of a smartphone * severe cognitive impairments

Keywords: chronic pain mobile health adolescents young adults fibromyalgia chronic widespread pain
effectiveness, safety and clinical outcomes of paritaprevir/ombitasvir/r+dasabuvir 8 weeks

Conditions: Hepatitis C Infection

Summary: the aim of the study is to evaluate in clinical practice the efficacy and safety of ombitasvir/paritaprevir/ ritonavir and dasabuvir administered for 8 weeks in treatment-naïve participants with genotype 1b hepatitis c virus (hcv).

hcv chronic infection affects 200 million people worldwide. hcv antiviral treatment has evolved rapidly since 2011. the introduction of direct-acting antivirals (daas) achieve great effectiveness with minimum saes and short treatment duration. however, studies evaluating efficacy and safety of ombitasvir/paritaprevir/ ritonavir and dasabuvir during 8 weeks are limited in real clinical practice. the aim of the study is to evaluate in clinical practice the efficacy and safety of ombitasvir/paritaprevir/ ritonavir and dasabuvir administered for 8 weeks in treatment-naïve participants with genotype 1b hepatitis c virus (hcv).

Eligibility criteria:
inclusion criteria: * chronic hepatitis c (anti-hcv antibodies and detectable hcv-rna). * genotype 1b infection * treatment-naïve and non-cirrhotic exclusion criteria: * hcv genotype or subtype other than gt1b. * any current or past clinical evidence of cirrhosis.

Keywords: hepatitis c infection ombitasvir/paritaprevir/ritonavir+dasabuvir
evaluate efficacy and safety of saxagliptin in adult patients with type 2 diabetes inadequate glycemic control

Conditions: Type 2 Diabetes

Summary: saxagliptin is a new investigational medication being developed for treatment of type 2 diabetes. this study is designed to evaluate the efficacy and safety in adult patients with inadequate glycaemic control with diet and exercise.


Eligibility criteria:
inclusion criteria: * diagnosed with type 2 diabetes * patients should be drug naïve ie, not received medical treatment for diabetes, * hba1c ≥ 7.2% and ≤10.0% (at enrolment), hba1c ≥ 7.0% and ≤10.0% (at randomization) exclusion criteria: * insulin therapy within one year of enrolment (with the exception of insulin therapy during a hospitalization or use in gestational diabetes), * type 1 diabetes,history of ketoacidosis or hyperosmolar non-ketonic koma

Keywords: dpp-4 inhibitors hba1c incretins
using values to enhance inmates' response to substance use and hiv risk feedback

Conditions: Substance Use; HIV Risk Behavior

Summary: a key component of effective offender treatment is an initial assessment of risk factors followed by feedback to facilitate problem awareness and engagement in appropriate treatment and/or behavior change. feedback regarding areas of high risk, however, can be experienced as threatening. the investigators propose to develop, fine-tune, and pilot-test a computerized system for risk assessment and feedback, including evaluation of a brief pre-feedback prosocial values affirmation exercise (cohen \& sherman, 2014) aimed at decreasing defensiveness and increasing inmates' willingness to access and process risk-relevant information and to utilize post-release treatment resources, thereby reducing post-release substance misuse, hiv risk behavior, and criminal recidivism. participants will be 170 jail inmates nearing release into the community - 20 pilot participants and 150 study participants randomly assigned to one of three conditions: (1) values affirmation + personalized risk feedback; (2) personalized risk feedback only; (3) control. the baseline and risk assessment, values affirmation manipulation, and personalized risk feedback will be presented via touch-screen computers, requiring minimal training to administer. analyses will assess: 1. the feasibility of utilizing a computerized system to assess and share risk information with jail inmates, including a brief values affirmation exercise to reduce defensiveness; 2. the acceptability of this approach from the perspectives of jail staff and inmates themselves; 3. the impact of the intervention on observed proximal outcomes (mechanisms of action), such as time spent viewing feedback, electing to print a copy of informational and treatment resources, and consequent changes in perceptions of risk, treatability, etc.; 4. the impact of the intervention on key post-release outcomes including engagement in relevant treatment services, substance misuse, hiv risk behaviors, re-offense and re-arrest; 5. the links between proximal outcomes (moas) and key post-release outcomes; 6. potential moderators of treatment effectiveness.


Eligibility criteria:
inclusion criteria: * sufficient proficiency in spoken english to understand computer-assisted assessments and feedback * post-sentencing with a sentence (i.e., less than 12 months) likely to be served out at the jail (vs. a state or federal prison) and likely to be released into the community. the invitation to participate will be timed so treatment is delivered toward the end of incarceration (within one week of release) to minimize decay of effects, and to capitalize on the motivational value of the up-coming release. exclusion criteria: * those with detainers to other jurisdictions and to immigration and customs enforcement (ice)
examining effects of holistic school enrichment programs

Conditions: Mindful Movement Intervention (MMI)

Summary: the investigators propose to evaluate the efficacy of a mindful movement intervention (mmi) within the baltimore city public school (bcps) system. the goal is to help at-risk youth improve skills important to attentional, behavioral, motor, and emotional control through engagement of mindful movement practices. to assess the feasibility and efficacy of the program, standardized assessments will be conducted at three time points: the beginning of the school year at the start of the intervention (early september), at the mid-year point (late january), and prior to the end of the school year (early june). during these assessments, participants will be pulled out of their academic classes for brief sessions (1 hour) in which they will complete assessments of attentional, behavioral, motor, and emotional control. at these assessment points, parents and teachers will complete rating forms about the children including assessments of emotional, behavioral, and attention regulation. research participants will have the option to reinforce mindful movement practices using a family-based curriculum, participating in peer mentorship, and supporting the development of community educational materials.


Eligibility criteria:
inclusion criteria: 1. students must be between the ages 7 years, 0 months and 15 years, 11 months, 30 days. 2. students with a diagnosis of depression, anxiety, autism, oppositional defiant disorder, and post traumatic stress disorder can be included in the research study 3. students taking stimulant medications and all other psychoactive medications can be included in the research study. 4. students in general education classrooms with supports, aides, and/or pull-outs exclusion criteria: 1. diagnosis of... * intellectual disability * a neurological disorder (e.g., epilepsy, cerebral palsy, traumatic brain injury, tourette syndrome) * conduct disorder or a recorded history of symptoms consistent with conduct disorder * a documented hearing impairment ≥ 25 db loss in either ear * significant learning difficulties that require a special education plan. 2. students in foster care 3. students who are or may be pregnant

Keywords: mindfulness attention deficit hyperactivity disorder (adhd)
early intervention in infants with perinatal stroke

Conditions: Stroke

Summary: this current study proposes to analyze the feasibility and effects of the two most used therapies, constraint-induced movement therapy and hand-arm bimanual intensive training, in very young infants (less than one year) with perinatal stroke and with a high risk to develop hemiplegic cp.

perinatal stroke constitutes an acute presentation of encephalopathy; manifesting as seizure, altered mental status, and/or neurological deficit; between birth and the twenty-eight postnatal day for which a pattern of ischemic brain injury in an arterial distribution is evident by neuroimaging. following perinatal stroke, approximately 60% of children develop cerebral palsy (usually presenting as spastic hemiplegia), 30-60% experience epilepsy, 25% show language delay, and up to 22% manifest behavioral problems. the current most predictive tools for early diagnosis of cp are a combination of brain mri/cus and a general movements (gm) assessment in the fidgety period (9). asymmetry of fidgety gms around 12 weeks post term can be the first clinical signs of hemiplegia. there are currently two intensive therapy approaches aiming at improving upper limb performance in adults and children (average age 8 years) with established hemiplegic cp: constraint induced movement therapy (cimt) and hand-arm bimanual intensive training (habit). those current therapy approaches fundamentally comprise repeated practice of desired movements based on motor learning principles with the adult/ child as an active participant. both therapies, in adults and in children with established hemiplegic cp (average age 8 years) are effective and show similar improvements if the dosage of therapy is similar. in contrast, the feasibility and the effects of both therapy approaches at very young age (under age 1 year) is still unknown (22). exploring these options to treat even before asymmetric hand use has appeared is interesting and promising enough since recent animal studies have demonstrated that there is a critical period of motor system plasticity, and that activity-dependent reorganization of the motor-projection pattern to the hand occurs before about 1 year of age

Eligibility criteria:
inclusion criteria: * infants with a perinatal stroke confirmed on neonatal imaging and from who the parents speaks dutch and live in belgium, will be included in the study. only infants showing abnormal 'general movements' between 10 and 15 weeks will be eligible for the intervention part. exclusion criteria: * infants with severe genetic abnormalities or malformations, with severe visual impairments or with uncontrolled seizures will be excluded.

Keywords: early intervention, infant