antineoplaston therapy in treating patients with low-grade non-hodgkin's lymphoma

Conditions: Low-Grade Lymphoma

Summary: current therapies for low-grade non-hodgkin's lymphoma provide limited benefit to the patient. the anti-cancer properties of antineoplaston therapy suggest that it may prove beneficial in the treatment of low-grade non-hodgkin's lymphoma. purpose: this study is being performed to determine the effects (good and bad) that antineoplaston therapy has on patients with low-grade non-hodgkin's lymphoma.

low-grade non-hodgkin's lymphoma patients receive gradually escalating doses of intravenous antineoplaston therapy (atengenal + astugenal) until the maximum tolerated dose is reached. treatment continues up to 12 months in the absence of disease progression or unacceptable toxicity. objectives: * to determine the efficacy of antineoplaston therapy in patients with low-grade non-hodgkin's lymphoma, as measured by an objective response to therapy (complete response, partial response or stable disease). * to determine the safety and tolerance of antineoplaston therapy in patients with low-grade non-hodgkin's lymphoma. * to determine objective response, tumor size is measured utilizing physical examination, radiologic studies, and bone marrow biopsies as necessary, performed every 8 weeks for the first two years, every 3 months for the third and fourth years, every 6 months for the 5th and sixth years, and annually thereafter.

Eligibility criteria:
disease characteristics: * histologically proven stage ii, iii, or iv low grade non-hodgkin's lymphoma that is unlikely to respond to existing therapy or for which no established therapy exists note: a new classification scheme for adult non-hodgkin's lymphoma has been adopted by pdq. the terminology of "indolent" or "aggressive" lymphoma will replace the former terminology of "low", "intermediate", or "high" grade lymphoma. however, this protocol uses the former terminology. patient characteristics: age: * 18 and over performance status: * karnofsky 60-100% life expectancy: * at least 2 months hematopoietic: * wbc greater than 2,000/mm\^3 * platelet count greater than 20,000/mm\^3 hepatic: * bilirubin normal renal: * creatinine normal * no history of renal conditions that contraindicate high dosages of sodium cardiovascular: * no hypertension * no history of congestive heart failure * no history of other cardiovascular conditions that contraindicate high dosages of sodium other: * not pregnant or nursing * fertile patients must use effective contraception during and for 4 weeks after study * no serious active infections prior concurrent therapy: biologic therapy: * at least 4 weeks since immunotherapy and recovered * no concurrent immunomodulating agents (e.g., interferon, interleukin-2) chemotherapy: * at least 4 weeks since prior chemotherapy (6 weeks for nitrosoureas) and recovered endocrine therapy: * at least 4 weeks since prior corticosteroids * no concurrent corticosteroids radiotherapy: * at least 8 weeks since prior radiotherapy and recovered surgery: * not specified other: * no prior antineoplaston therapy * no other concurrent antineoplastic agents * no concurrent antibiotics, antifungals, or antivirals

Keywords: low-grade non-hodgkin's lymphoma