Kornimate/medical-research-clean huggingface dataset:
vaccine therapy in treating patients with non-small cell lung cancer (nsclc) stages iiib/iv

Conditions: Non-small-cell Lung Cancer (NSCLC) Stage IIIb/IV

Summary: the purpose of this study is to determine whether the recombinant human egf-rp64k/montanide isa 51 vaccine is safe, immunogenic and effective in the treatment of stage iiib/iv non-small-cell lung cancer (nsclc).


Eligibility criteria:
inclusion criteria: * patients who have signed the informed consent form. * patients who are eighteen years of age or over with histologically or cytologically confirmed nsclc in advanced stages iiib or iv, not amenable to any attempt of curative chemo-radiotherapy and/or surgery. * patients with measurable lesions, defined as those measurable at least in one dimension (refered to higher diameter) and with a diameter equal or higher 20 mm using conventional techniques (pet, ct scan, mri, rx) or equal or higher 10 mm using ct scan. * patients who have finished their last cycle of chemotherapy and/or radiotherapy not less than 4 weeks prior to randomization and not more than 8 weeks. * female patients of reproductive potential must have negative pregnancy tests. those female volunteers admitted to the study must be using a reliable means of contraception such as tubal ligation, oral contraceptive or iud. * ecog status 0 to 2. * patients with normal organ and bone marrow function, as defined by the parameters in accordance to that provided by the normal lab reference range. * patients with no evidence of objective disease progression, 1 month after finishing first line chemotherapy as per recist. exclusion criteria: * patients who are candidates for combined modality treatment. * patients who are receiving immunosuppressive therapy including corticosteroids. * patients who have received immunotherapy within the previous 3 months. * patients who have participated in a clinical study within the previous 30 days. * patients who may be allergic to any component of the vaccine. * medical reasons considered by the investigators as disqualification from the study such as significant uncontrolled co-morbid disease or potential non-compliance with the protocol. * patients bearing brain metastasis from the primary lung tumor. * patients bearing a second primary tumor. * patients showing progressive disease after finishing first line chemotherapy.

Keywords: lung cancer nsclc egf cancer vaccine immunotherapy
differential regulation of mirna and protein in human plasma extracellular vesicles by different types of exercise.

Conditions: Diabetes; Exercise; Lifestyle Intervention

Summary: aims/hypothesis: both continuous aerobic training (cat) and high intensity interval training (hiit) are recommended to promote health and prevent diseases. exercise-induced circulating extracellular vesicles (ex-evs) have been suggested to play essential roles in mediating organ crosstalk, but corresponding molecular mechanisms remain largely unexplored. we aimed to assess and compare the systemic effects of cat and hiit via multi-omics integration analysis of ex-evs. methods: five healthy male volunteers were assigned to hiit (20 minutes of cycling with periods of 2 minutes at 80-95% hrmax separated by 2 minutes of active recovery) and cat (20 minutes of cycling at 60-80% of hrmax), with a 7-day interval between sessions. plasma evs were collected at rest or immediately after each training section, prior to proteomics and mirna profile analysis.

before the formal experiment, the volunteers were undergoing a thorough physical examination and proper training to ensure that they were able to complete the experiment. the participants refrained from exercise 24 hours prior to the test to ensure the integrity and accuracy of the results. all volunteers had a standardized breakfast, and all tests started at 9:00 a.m. the volunteers successively completed both hiit and cat under the supervision of a professional coach, and the interval between each type of exercise was 7 days. each training session was initiated with a brief 2-minute standardized warm-up, followed by 20 minutes of cycling consisting of periods of 2 minutes at 80-95% maximal heart rate (hrmax) separated by 2 minutes of active recovery for the hiit group or 20 minutes of cycling at 60-80% of hrmax for the cat group. a real-time heart rate monitoring system was continuously used during each training session. the participants were instructed to continue their regular physical activities and eating habits throughout the intervention period. blood samples were collected at rest or immediately after each training session for further analysis.

Eligibility criteria:
inclusion criteria: 18-65 years of age body mass index (bmi) values between 18-28 kg/m2 more than 3 h of physical activity per week acknowledgment of informed consent. - exclusion criteria: smokers body weight change \&gt;5 kg in 6 months unsuitable for physical training (heart disease, respiratory disorders or any conditions that could be aggravated by exercise) currently taking medication or having a history of medication such as steroids, beta-blockers or anticoagulants.
individual and work-related risk factors for musculoskeletal pain: a cross-sectional study among turkish office workers

Conditions: Musculoskeletal Pain; Disability Physical

Summary: most studies investigating the risk factors related with musculoskeletal pain have been conducted in european countries and north america, and because of the difference in health, economic, and social systems, their results are not generalizable to countries such as turkey. therefore, the aim of the present study is to investigate the individual and work-related risk factors linked to musculoskeletal pain among turkish office workers.

a total of 150 participants, who are office workers in turkey, are included in the present study. data collection will be carried out using the online survey. the online survey link will be shared via social media accounts and via mail. the questionnaire created through google forms will be delivered to the participants via the link. the link will be active in the data collection process. before the participants start the questionnaire, they will be asked whether they were willing to participate. the socio-demographic characteristics (age, gender, body mass index) and health status (presence of chronic disease, drugs used and history of injury) will be questioned. in addition, the information about the sector, working hours, time spent at work and out of work, additional working hours, break times at the workplace will be collected. the standardized scandinavian musculoskeletal questionnaire will be used to assess musculoskeletal complaints. participants with musculoskeletal pain will be referred to the assessment questionnaire appropriate for the localization of the region where they feel the most pain. participants with neck pain will be evaluated with the neck disability scale. arm-shoulder-hand disability survey-short form will be used for participants with wrist, shoulder or arm pain. oswestry disability index will be used to determine the degree of disability in individuals with low back pain.

Eligibility criteria:
inclusion criteria: * the participants included in this study will be aged between 18 and 55 years, men or women, an office worker and able to understand and read turkish as a language. exclusion criteria: * participants excluded from the study if they have any musculoskeletal disease, a spine curvature disorders such as scoliosis, kyphosis, kyphoscoliosis, undergone surgery affecting the musculoskeletal system within the last 1 month, or been pregnant for women.
extracorporeal shockwave therapy for diabetic foot wounds

Conditions: Diabetic Foot; Wound

Summary: diabetic wounds post digital amputation have poor healing in 30-45% of cases, resulting in 75% of patients undergoing a further amputation within the year, despite best wound management. extracorporeal shockwave therapy is a promising safe and non invasive treatment that has been shown to improve healing in chronic ulcers and burns by promoting healing and decreasing risk of infection. the study will recruit patients on a hospital ward and outpatient departments who have a diabetic foot wound. participants will be informed about the study, given an patient information sheet and invited to give informed consent. consenting participants will undergo shockwave therapy three times in the seven days after their operation, in addition to standard wound care. wound measurements, blood perfusion, tissue integrity, quality of life and pain scores will be recorded at baseline, after the third treatment, 4 weeks, 8 weeks and 12 weeks after recruitment to the study. the study aims to recruit 25 patients.


Eligibility criteria:
inclusion criteria: * diagnosis of diabetes mellitus * open wound of the foot * abpi \>0.8 * age greater than 18 years old * able and willing to give written informed consent * be able to adhere to protocol and attend all follow up appointments exclusion criteria: * pregnancy or breast-feeding * current malignancy * allergy to materials used in the treatment * palliative * unable or unwilling to give consent * anticoagulation

Keywords: diabetic foot wound
phase 2 study of vx-950, pegasys® with and without copegus® in hepatitis c

Conditions: Chronic Hepatitis C

Summary: compare the effectiveness of telaprevir (vx-950) in combination with pegylated interferon alfa 2a (peg-ifn-alfa-2a) with and without ribavirin (rbv) in reducing plasma hepatitis c virus (hcv) ribonucleic acid (rna) levels


Eligibility criteria:
inclusion criteria: * hepatitis c virus genotype 1 with detectable plasma hepatitis c virus rna * have been infected with hepatitis c virus for greater than (\>) 6 months * seronegative for hepatitis b surface antigen and human immunodeficiency virus 1 and 2 * must agree to use 2 methods of contraception, including 1 barrier method, during and for 24 weeks after the completion of the study (unless the subject is a female of documented non-child-bearing potential) * female subjects must have a negative pregnancy test at all visits before the first dose. exclusion criteria: * received any approved or investigational drug or drug regimen for the treatment of hepatitis c. * any medical contraindications to peg-ifn-alfa-2a or ribavirin therapy * any other cause of significant liver disease in addition to hepatitis c; this may include but is not limited to, hepatitis b, drug or alcohol-related cirrhosis, autoimmune hepatitis, hemochromatosis, wilson's disease, nonalcoholic steatohepatitis or primary biliary cirrhosis. * diagnosed or suspected hepatocellular carcinoma. * histologic evidence of hepatic cirrhosis (including compensated cirrhosis) based on a liver biopsy taken within 2 years before study start. * alcohol/drug abuse or excessive use in the last 12 months. * participation in any investigational drug study within 90 days before drug administration or participation in more than 2 drug studies in the last 12 months (exclusive of the current study).
telephone care as a substitute for routine psychiatric medication

Conditions: Major Depression; Posttraumatic Stress Disorders; Anxiety Disorders

Summary: the purpose of this study is to answer the following questions: (1) does substituting brief, scheduled, clinician-initiated telephone calls (telephone care) for routine psychiatric medication management visits reduce overall healthcare utilization? (2) is substituting brief, scheduled, clinician-initiated telephone calls (telephone care) for routine psychiatric medication management visits as effective as routine care?

telemedicine uses communications technologies to provide health care when distance separates participants. applied to general medical care practice, telemedicine is associated with improved continuity of care, cost-effectiveness, and improved service quality. to date, all evaluations of telepsychiatry have concentrated on video technology. the telephone is more readily available and less expensive communication technology that has not been evaluated as a method of health services delivery in the medication management of stable psychiatric outpatients. we will enroll 346 psychiatrically stable subjects, who carry a diagnosis of major depression, post-traumatic stress disorder (ptsd) or non-ptsd anxiety disorder. we will use a balanced randomization strategy to assign subjects to routine care or telephone care for a two-year period within each provider panel. patients randomized to receive routine care will be scheduled to see their psychiatric medication provider at the recommended interval. patients randomized to receive telephone care will be scheduled to see their provider at twice the recommended clinic visit interval, and two ten-minute telephone contacts will be scheduled at a specific time at standard 0.67 and 1.3 times the multiple of the recommended interval. at two years, we will use ten data sources to compare two primary outcomes (total vha health services utilization and mental health component scores from the sf-12-v) as well as vha costs, imputed non-vha costs, patient and provider satisfaction, medication compliance and diagnosis specific outcomes.

Eligibility criteria:
inclusion criteria: * patients will be eligible for this study if they carry a diagnosis of major depression, post-traumatic stress disorder (ptsd), or non-ptsd anxiety disorders. * they must be psychiatrically stable subjects with a global assessment of functioning scale score of \>50, no psychiatric hospitalizations in the previous six months, and no active substance abuse disorders. exclusion criteria: * psychiatric hospitalization within 6 months prior to study entry. * visit interval \>1 year. * lack of telephone access. * inability to use a telephone. * gaf\<50.

Keywords: telephone telemedicine psychopharmacology
dietary behaviour change intervention among older people with sarcopenic obesity

Conditions: Sarcopenic Obesity

Summary: the aim of this study is to evaluate the feasibility and preliminary effects of dietary behavior change intervention on the management of sarcopenic obesity (so) among older people in the community. the feasibility and preliminary effects of the intervention will be tested using a two-armed pilot randomized controlled trial among older people (n=60) with so in the community in nanjing, china. finally, 10 participants will be invited to join a semi-structured interview to explore their perceptions about the whole intervention process. it is hypothesized that the experimental group will have a greater improvement in the body composition, muscle strength and physical function compared to the control group after receiving the 15-week dietary behavior change intervention.

the pilot study is a single-blind, two-arm randomized controlled trial. a total of 60 subjects (60 years old or more) are planned to be recruited. the subjects will be randomly divided into 2 groups witht a ratio of 1:1. one is the experimental group and the other is the control group. the experimental group will receive 15 weeks of dietary intervention, including 6 face-to-face meetings and weekly telephone call. each meeting lasts for 1 hour. the participants in the experimental group are required to control of calorie intake (decrease energy intake by 12%) and increase protein intake (1.2-1.5 g/body weight kg/day), and take dietary diary. the control group will not receive any dietary interventions. they will only receive regular contacts with a similar frequency as the experimental group. the content of the conversations will not involve any topics related to so. after the intervention, 10-15 people from the experimental group will be randomly selected to receive semi-structured individual interview, which will last around 1 hour. the researcher plan to understand their feelings about participating in the study.

Eligibility criteria:
inclusion criteria: * community-dwelling older people aged 60 years old or above; * handgrip strength \< 28 kg for men and \< 18 kg for women; * bmi ≥ 28% or waist circumference ≥ 85 cm in men and ≥ 80 cm in women; * be able to read and write without severe hearing and vision problems. exclusion criteria: * suffering from severe heart disease or metabolic disorders (e.g. renal diseases, diabetes) or autoimmune disease, cancer, or any other diseases/ conditions which may affect food intake and digestion or amputee; * cognitively impaired (e.g. dementia) may impede the delivery of the intervention; * under special diet restriction such as on diabetes disease diet, vegetarian, ketogenic diet, etc.; * using of medications that may influence eating behavior, digestion or metabolism (such as weight loss medication); * addicted to alcohol; * a metal device is implanted in the body; * be engaged in another trials.

Keywords: dietary behaviour change sarcopenic obesity community randomized controlled trial
the effect of special discharge training in the covid-19

Conditions: COVID-19 Pneumonia

Summary: this study aimed to evaluate the impact of specialized discharge education on the daily life activities and quality of life of geriatric patients hospitalized in covid-19 wards. the motivation behind this study stems from the vulnerability of elderly patients during the covid-19 pandemic and the necessity of tailored education to support their daily life activities and enhance their quality of life after discharge. the primary objective of this article is to determine the specific type of specialized discharge education that geriatric patients in covid-19 wards require to improve their ability to sustain daily life activities and enhance their quality of life. the central idea of this study is that providing specialized discharge education to geriatric patients in covid-19 wards can result in improvements in their daily life activities and quality of life. the main findings of the study demonstrate a significant enhancement in daily life activities and quality of life among patients who received specialized discharge education. these individuals exhibited increased independence in mobility, improved performance in daily life activities, and reported an overall improvement in their quality of life. these findings underscore the significance of specialized discharge education for geriatric patients hospitalized in covid-19 wards and highlight its positive impact on their health outcomes and quality of life.

purpose: this research aimed to determine the impact of specialized discharge training on the daily living activities and quality of life of geriatric patients admitted to the covid-19 ward. materials and methods: a quasi-experimental study was conducted on geriatric patients admitted to a training and research hospital's covid-19 ward between april 1 and july 1, 2022. a control group of 40 individuals and a study group of 40 individuals, both meeting the inclusion criteria, were established. research data were collected using the descriptive features form, katz index of independence in activities of daily living, and sf-12 quality of life scale.

Eligibility criteria:
inclusion criteria: * the inclusion criteria for the study were as follows; willingness to participate in the research, age 65 and over, hospitalized geriatric patients in the pandemic service, openness to communication and cooperation, sound mental health, absence of sensory impairments such as vision, hearing, and speech. exclusion criteria: * patients who do not meet the inclusion criteria

Keywords: covid-19 special discharge training geriatric daily life activities quality of life
mindfulness-based stress reduction in multiple sclerosis

Conditions: Multiple Sclerosis

Summary: this application concerns a proposed randomised controlled trial evaluating the use of mindfulness-based stress reduction (mbsr) in people with multiple sclerosis (ms) in secondary care. ms is an inherently stressful condition, and stress is thought to exacerbate ms. mental health problems are common in ms, can impair quality of life, and lead to higher rates of suicide. prior research has shown that cognitive behavioural therapy (cbt) can help mitigate stress and diminish disease activity in ms, but effects are short-lived and there is thus a need to explore whether other psychological approaches might be more beneficial in this regard. mbsr is another psychological stress reduction technique that is thought to operate differently to cbt, via cultivating a state of "meta-cognitive awareness" and has shown to be helpful when used in other long term conditions, such as chronic pain and anxiety, whilst mindfulness-based cognitive therapy (mbct - a derivative of mbsr) is effective in treating recurrent depression. all of these conditions are common in ms. however, mindfulness based interventions have not been well studied in ms. the investigators propose to carry out a feasibility study to assess how acceptable and accessible mbsr is as a stress reduction technique in people with ms. the investigators would seek up to 50 participants who would then be randomly assigned to receive mbsr or their usual care. the investigators would seek measurements of health and wellbeing before, immediately following, and 3 months following the mbsr intervention. this would include basic demographic information (age, gender, ethnicity), measures of mental health, and physical health, as well as qualitative semi-structured interviews with selected participants. after this we would offer mbsr to the control group.


Eligibility criteria:
inclusion criteria: * having at baseline a neurologist confirmed diagnosis of ms * can understand spoken and written english * score of less than or equal to 7 on the expanded disability status scale exclusion criteria: * potentially life threatening physical or mental health comorbidities or conditions expected to significantly limit participation and adherence * current receipt of another form of psychological intervention (non-pharmacological)