Kornimate/medical-research-clean huggingface dataset:
effects of malnutrition on colon cancer patients with abdominal surgery

Conditions: Malnutrition; Colon Cancer

Summary: the prevalence of malnutrition in patients with colorectal cancer is recorded. we want to find out, if a malnourished patient has more complications after the elective surgery.

all patients attending elective colorectal surgery are screened for malnutrition in advance. their length of stay in the hospital and the complications are recorded.

Eligibility criteria:
inclusion criteria: * colorectal carcinoma * elective surgery * informed consent exclusion criteria: * survival \< 4 weeks

Keywords: malnutrition colon cancer colon surgery outcome complication rate
a study to determine the difference in low contact stress (lcs) duofix versus low lcs porocoat knee systems

Conditions: Osteoarthritis

Summary: the primary objective of this investigation is to test the hypothesis that the duofix tibial component results in a reduction of immediate postoperative pain compared to the lcs porocoat version.

the secondary objectives of this investigation are to evaluate the clinical and patient outcomes, biological fixation and survivorship associated with the lcs duofix and porocoat knee system over 10 years.

Eligibility criteria:
inclusion criteria: * male or female subjects. * subjects who are able to give voluntary, written informed consent to participate in this investigation and from whom consent has been obtained. * subjects who, in the opinion of the investigator, are able to understand this investigation, co-operate with the investigational procedures and are willing to return to the hospital for all the required post-operative follow-ups. * subjects who present with idiopathic osteoarthritis, rheumatoid arthritis, post traumatic arthritis or any other pathology that in the opinion of the clinical investigator requires a primary total knee arthroplasty and who are considered suitable for treatment with a cementless mobile bearing knee system (lcs complete). * subjects who in the opinion of the clinical investigator are considered to be suitable for treatment with both the investigational devices, according to the indications specified in the package insert leaflet. exclusion criteria: * subjects who, in the opinion of the investigator, have an existing condition that would compromise their participation and follow-up in this study. * subjects with a known history of poor compliance to medical treatment. * women who are pregnant. * subjects who are known drug or alcohol abusers or with psychological disorders that could affect follow-up care or treatment outcomes. * subjects involved in medical-legal claims. * subjects who have participated in a clinical study with an investigational product in the last month. * subjects who are currently involved in any injury litigation claims. * revision of an existing knee implant.

Keywords: arthroplasty, replacement, knee, lcs duofix, porocoat
myofascial trigger points of the levator scapulae muscle

Conditions: Myofascial Pain Syndrome

Summary: chronic neck pain (cnp) is considered one of the most common musculoskeletal disorders worldwide and myofascial pain syndrome (mps) is the most prevalent musculoskeletal disorder in the majority of the population. however, normal tissue contractility changes and the different types of myofascial trigger points (mtrps) measured by tensiomography have not yet been studied. for this reason, the aim of our study is to determine the differences in pressure pain threshold (ppt), tensiomyography and sonoelastography between the palpation zone of control points with respect to active and latent mtrps in the levator scapulae muscles of subjects with cnp. a single-blind descriptive cross-sectional study is conducted with a convenience sample of 60 points (20 active, 20 latent and 20 control points) on both sides of the subject in the levator scapulae muscles of individuals diagnosed with cnp. the order of outcome measurements for each point was ppt, manual tension index sonoelastography and tensiomyography separated by 15 minutes. objective contractile parameters were: contraction time (tc), mean relaxation time (tr), maximum radial displacement (dm), holding time (ts) and delay time (td).


Eligibility criteria:
inclusion criteria: * bilateral presence of at least one active trigger point. * one control point and one latent trigger point in the levator scapulae muscles. * subjects aged between 18 and 65 years. * subjects diagnosed with chronic neck pain for more than 6 weeks. * signed informed consent to be able to participate in the study. exclusion criteria: * previous treatment for chronic neck pain (within one year) or medical history with a diagnosis of neuropathy. * rheumatoid arthritis. * myopathy. * cognitive impairment or mental disability. * skin disorders. * pregnancy. * activity level of a high-level athlete. * medical conditions (fractures, structural deformities and neoplasms). * surgical interventions in the cervical-dorsal region or upper extremities.

Keywords: physiotherapies techniques sonoelastography; muscle tension neck pain
evaluation of changes of venous return after spinal and epidural analgesia and anesthesia by ultrasound guided vena cava diameter measurement

Conditions: Pregnancy Related; Hypotension, Orthostatic

Summary: the investigators propose this study to test the hypotheses that inferior vena cava (ivc) diameter can predict hypotension after labor analgesia (epidural, combined spinal-epidural) and neuraxial anesthesia for cesarean section (epidural, combined spinal-epidural and spinal block) in full-term pregnant patients.

after approval by the institutional review board and patient consent, term pregnant patients (\>37 week gestation) admitted to the obstetric service of augusta university medical center, who require administration of neuraxial analgesia for labor or regional anesthesia for cesarean section, will be included in the study. the consent will be obtained by the attending, resident or medical student in which the investigators will explain to the patient the procedure, benefit, risk, cost and, confidentiality. the investigators plan to get the consent immediately after the patient arrived at the unit to avoid any interference with the delivery process. if the patient needs to go to an emergency cesarean section. this patient is not going to be included in the study. demographic variables (age, bmi, gravity, parity and gestation weeks) and hemodynamic variables (map and hr) will be recorded. all patients will be lying in supine position, breathing spontaneously. the ultrasound examination will be performed before commencement of the neuraxial procedure and will be repeated two minutes after administration of the neuraxial anesthetic. ultrasound measurements will be made with a sonosite edge (sonosite inc. usa) machine and a c60x curved linear phased array transducer (sonosite inc.) set to abdominal mode. all measurements will be made by two attending anesthesiologists (erp and ar) who have experience in transthoracic echocardiography, and a resident who receives the basic instruction to measure ivc diameter. the medical student will be present during the procedure and will ensure that the study echocardiographic views are taken. the ivc will be visualized using a paramedian long-axis view via a subcostal approach according to guidelines of the american society of echocardiography. a two-dimensional image of the ivc will be obtained and pulsed wave doppler will be used to differentiate from the aorta. variations in ivc diameters will be assessed with m-mode applied 2 cm. distal to the right atrium. to ensure consistent measurements, each operator will take three images. the best quality images are chosen. maximum and minimum ivc diameters during a single respiratory cycle will be measured.

Eligibility criteria:
inclusion criteria: 1. pregnant patients \>37 weeks of gestation 2. indication for neuraxial labor analgesia or regional anesthesia for cesarean section 3. age older than 18 years 4. pregnancy without diagnosed comorbidities exclusion criteria: 1. unwillingness to participate in the study 2. diagnosis of hypertensive disorders of pregnancy 3. diagnosis of cardiopulmonary disease 4. allergy to us gel
evaluation of ave5026 as compared to enoxaparin for the prevention of thromboembolism in patients undergoing total hip replacement surgery

Conditions: Venous Thromboembolism

Summary: the primary objective was to compare the efficacy of once daily \[q.d.\] subcutaneous \[s.c.\] injections of semuloparin sodium (ave5026) with q.d. s.c. injections of enoxaparin for the prevention of venous thromboembolic events \[vte\] in patients undergoing elective total hip replacement surgery. the secondary objectives were to evaluate the safety of ave5026 in patients undergoing elective total hip replacement surgery, and to document ave5026 exposure in this population.

randomization had to take place just prior the first study drug injection (randomization ratio 1:1). the total duration of observation per participant was 35-42 days from surgery broken down as follows: * 7 to 10-day double-blind treatment period; * 28 to 35-day follow-up period. mandatory bilateral venography of the lower limbs had to be performed 7 to 11 days after surgery.

Eligibility criteria:
inclusion criteria: * elective total hip replacement surgery or a revision of at least one component of a prosthesis implanted ≥ 6 months prior to study entry. exclusion criteria: * any major orthopedic surgery in the 3 months prior to study start; * deep vein thrombosis or pulmonary embolism within the last 12 months or known post-phlebitic syndrome; * high risk of bleeding; * known allergy to heparin or enoxaparin; * any contra-indications to the performance of venography; * end stage renal disease or patient on dialysis. the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.

Keywords: vte prevention total hip replacement heparin low-molecular-weight
effectiveness and cost-effectiveness evaluations of ai-assisted diagnostic software (verisee) for ophthalmic disease screening

Conditions: Age-Related Macular Degeneration (AMD); Diabetic Retinopathy (DR); Glaucoma

Summary: this study aims to evaluate the effectiveness of an artificial intelligence (ai)-assisted screening system in ophthalmic diagnosis. using ai-based fundus photography, the system will assist physicians in diagnosing three common eye diseases: age-related macular degeneration, diabetic retinopathy (dr), and glaucoma. the ai system will analyze fundus images from participants and rapidly generate detection results for ophthalmologists' reference in making final diagnoses and clinical decisions. the study will assess the clinical benefits of the ai-assisted diagnostic system, providing scientific evidence to enhance the efficiency of ophthalmic disease diagnosis and treatment.

artificial intelligence (ai) has shown significant potential in medical imaging analysis and disease diagnosis, particularly in ophthalmology. substantial advancements have been made in utilizing ai for diagnosing common ophthalmic diseases, enhancing early detection and improving patient outcomes. early diagnosis of age-related macular degeneration (amd), diabetic retinopathy (dr), and glaucoma (glc) is crucial for effective treatment and disease management. however, current clinical diagnoses rely heavily on ophthalmologists, leading to challenges such as low patient attendance rates and unequal distribution of diagnostic resources. to address these issues, this study adopts a before-and-after trial design to assess the impact of the verisee ai-assisted diagnostic system. the study involves both prospective data collection from screenings and retrospective analysis of past patient data. verisee amd, verisee dr, and verisee glc are ai-powered medical software tools designed to screen for amd, dr, and glc, respectively. these systems employ advanced ai algorithms to analyze color fundus photography images, assess disease conditions, and evaluate image quality. by integrating this software into clinical workflows, physicians receive instant diagnostic support, improving efficiency and accessibility in ophthalmic disease screening.

Eligibility criteria:
inclusion criteria: * verisee amd is used in non-retinal subspecialty ophthalmology clinics for adults aged 50 and above. * verisee dr is used in non-retinal subspecialty clinics for diabetic patients aged 20 and above. * verisee glc is used in non-glaucoma subspecialty ophthalmology clinics for adults aged 20 and above with myopia less than 1000 degrees. exclusion criteria: * the patient does not agree to participate in the trial or is unable to provide informed consent.

Keywords: artificial intelligence imaging analysis disease diagnosis macular degeneration diabetic retinopathy glaucoma
bioenergetics and metabolomics in cystic fibrosis

Conditions: Cystic Fibrosis

Summary: with better medical care, patients with cystic fibrosis (cf), a life-threatening disease, are enjoying longer lives. as the cf life expectancy increases, conditions such as cf-related diabetes (cfrd) become more prevalent. nutrition plays a major role in maintaining optimal health in cystic fibrosis (cf). this project is designed to investigate nutrition-related factors, such as diet and body composition, on outcomes in patients with cf. the data generated from this study will be used to inform future nutrition intervention studies in adults with cf and cfrd.

research methods include blood draws for plasma markers of oxidative stress and metabolomics (the measurement of thousands of small chemicals in the blood), magnetic resonance imaging (mri, to assess energy capacity and thigh fat), dual energy x-ray absorptiometry (dexa, to assess total and regional body fat and muscle), and indirect calorimetry (to assess resting energy expenditure and whole body fat oxidation). clinically-relevant data, such as lung function, cf genotype, and diabetes status will be obtained from the electronic medical record and the cf registry.

Eligibility criteria:
cystic fibrosis inclusion criteria: * have confirmed cf diagnosis with at least one class i to iii cftr mutations * age ≥ 18 yrs * on a clinically-stable medical regimen for 3 wks * no intravenous or oral antibiotics for at least 3 wks prior to study visit exclusion criteria: * current pregnancy * unwilling or unable to discontinue enteral tube feeds for one night before the study visit, if applicable * most recent fev1% \<40% * drug (recreational or prescription) or alcohol abuse * pacemaker or any electronic implantable device * unable to give informed consent healthy volunteers inclusion criteria: * 18-50 yrs of age * ambulatory status * absence of hospitalization in the previous year except for accidents exclusion criteria: * current pregnancy * current active malignant neoplasm or history of malignancy (other than localized basal cell cancer of the skin) during the previous 5 years * current respiratory disease including asthma, chronic obstructive pulmonary disorder, or emphysema * current chronic autoimmune or pro-inflammatory disease * history of tuberculosis, hiv, or other chronic infection * previous diagnosis of type 1 or type 2 diabetes with active treatment with insulin or other glucose lowering medication * advanced (≥ stage 3) renal disease * body mass index (bmi) ≥ 30 kg/m2 * acute illness (such as a viral infection) within the past 2 weeks * current use of any prescription medications that would indicate presence of an acute or chronic medical condition that may influence study results * drug (recreational or prescription) or alcohol abuse * weight instability (± 10% body weight within the last 6 months) or current participation in weight loss or weight gain program * inability to provide informed consent.
pulmonary rehabilitation after pregnancy in covid-19 infection: a case report

Conditions: COVID-19 Pneumonia; Pulmonary Rehabilitation; Pregnancy

Summary: the 33-month pregnant patient was followed in the gynecology service with the complaint of shortness of breath after receiving the covid positive diagnosis and was transferred to the intensive care unit due to acute respiratory failure. she was intubated in the intensive care unit and the baby was taken by cesarean section. pulmonary rehabilitation steps to be applied to the patient with long-term intensive care hospitalization will be examined.

after the patient was admitted to the chest diseases service, pulmonary rehabilitation was started. the patient was evaluated before starting pulmonary rehabilitation. evaluation parameters; vital signs, shortness of breath, oxygen support, grip force and pinchmeter, fatigue, anxiety and depression, cognitive functions. the pulmonary rehabilitation program will be implemented every day during the hospitalization. the pulmonary rehabilitation program will consist of breathing exercises, strengthening training of upper and lower extremity, exercises in bed, mobilization and reducing oxygen support. the patient will be re-evaluated before discharge.pulmonary rehabilitation after discharge will continue 2-3 days a week.the patient will be re-evaluated at the 3rd, 6th, 9th and 12th months.

Eligibility criteria:
inclusion criteria: -pregnant and covid patient exclusion criteria:

Keywords: covid-19, pulmonary rehabilitation, pregnant
electrophysiological evaluation of motor dysfunction in liver cirrhotic patients

Conditions: Liver Cirrhoses; Peripheral Neuropathy

Summary: cross sectional observational study, aimed to assess the electrophysiological function of the motor units in liver cirrhotic patients.

liver cirrhosis is a global health problem which could be associated with several neurological manifestations. the associated peripheral neuropathy could be assessed by conventional nerve conduction studies. objective: the study aims at early detection of peripheral neuropathy among patients of liver cirrhosis by conventional nerve conduction studies and quantitative emg methods. in addition, the study aims at finding out correlation between peripheral neuropathy and severity of the liver cirrhosis. methods: this a cross-sectional study conducted on fifty-six liver cirrhotic patients, that had been recruited from the endemic medicine department/outpatient clinics and their age-gender matched sixty-one healthy controls. the recruited patients were clinically assessed .both conventional nerve conduction studies and quantitative emg techniques in the form of mune calculation, using modified spike -triggered technique and ipa ratio evaluation were performed for the allocated cirrhotic patients.

Eligibility criteria:
inclusion criteria: * both genders. * age interval range between 18 and 60 years (to avoid maturational changes and aging process on motor unit number). * liver cirrhotic patients( including compensated and decompensated patients); * presenting hematemesis/melena and/or ascites. * diagnosis of liver cirrhosis is confirmed by abdominal ultrasound exclusion criteria: * patients with identifiable cause of peripheral neuropathy (e.g. diabetic patients) . * patients who developed hepatocellular carcinoma (to avoid para-neoplastic syndrome e.g. peripheral neuropathy) * patients with other non-hepatic chronic illness such as: patients with renal disease (to avoid other causes of metabolic neuropathies).

Keywords: liver cirrhotic patients- motor dysfunction-fatigue.
sugammadex v.s. neostigmine/glycopyrrolate

Conditions: Head and Neck Neoplasms; Chronic Sinusitis; Chronic Otitis Media

Summary: the aim of study is to clarify the role of sugammadex in head and neck surgery patients with a prior history of urinary retention, benign prostatic hypertrophy, or a history of prostate cancer, to prevent postoperative urinary retention. the main question it aims to answer are: * anticholinergic agent interferes the postoperative urination * sugammadex does not interfere postoperative urination sugammadex can be recommended for these patients with high risk in postoperative urinary retention in the future.

investigators will evaluate the benefit of sugammadex in reducing postoperative urinary retention for these head and neck surgery patients with high-risk for dysuria. the definition of high-risk of dysuria is patient with a prior history of urinary retention, benign prostatic hypertrophy, or a history of prostate cancer. patients scheduled to undergo head and neck surgery within two hours of expected surgical time are enrolled. these patients are associated with high-risk of postoperative urinary retention, including prior history of urinary retention, benign prostatic hypertrophy, or a history of prostate cancer. they are randomly divided these patients into sugammadex group (s group) and neostigmine/glycopyrrolate group (group n), sugammadex or neostigmine/glycopyrrolate are used during recovery period of anesthesia, to compare the incidences of postoperative urinary retention, nausea/vomiting, bradycardia, hypotension, and dry mouth in these patients after head and neck surgery. sugammadex can be recommended for these high-risk patients in the future.

Eligibility criteria:
inclusion criteria: * head and neck surgery patients whose surgery is expected to take less than two hours * prior history of postoperative urinary retention * benign prostatic hypertrophy * history of prostate cancer exclusion criteria: * refusal or inability to provide informed consent * age younger than 18 years * american society of anesthesiologists class more than iii

Keywords: sugammadex anticholinergic drug postoperative urinary retention head and neck surgery neostigmine