Kornimate/medical-research-clean huggingface dataset:
screening for latent tuberculosis infection (ltbi) in us army recruits

Conditions: Latent Tuberculosis Infection

Summary: the overall objective of this study is to assess the feasibility and potential impact of using a targeted testing approach and 2 interferon-gamma release assays (igra) to screen for latent tuberculosis (tb) infection (ltbi) among military recruits. the current policy of universal application of the mantoux tuberculin skin test (tst) to screen for ltbi may result in many tst reactions among recruits who are at low risk for ltbi. the central hypothesis is that targeted testing by use of the questionnaire will reduce unnecessary testing of low-risk recruits without affecting the identification of higher-risk recruits. the secondary hypothesis is that many discordant results between the tst and igra may be explained by cross-reactivity to non-tuberculous mycobacteria (ntm) with the tst.


Eligibility criteria:
inclusion criteria: * any recruit, age 18 years or older, undergoing routine entry-level medical processing at fort jackson exclusion criteria: * if they have history of severe reactions to tst (e.g., blistering, scar, or symptoms of immediate hypersensitivity) * if they are unwilling to provide written consent for the study * if they are unwilling to provide health insurance portability and accountability act (hipaa) authorization

Keywords: tb tuberculosis diagnosis tb screening
endovenous radiofrequency versus laser ablation for the treatment of great saphenous vein reflux

Conditions: Varicose Veins

Summary: our aim is to compare early outcomes following evl 1320 nm and segmental rf in a randomized study.

endovenous radiofrequency versus laser ablation for the treatment of great saphenous vein reflux

Eligibility criteria:
inclusion criteria: * patients between the ages of 18 and 60 years with incompetent gsvs documented on duplex ultrasound (us; b-mode and color doppler imaging) were eligible exclusion criteria: * exclusion criteria consisted of: * current deep vein thrombosis (dvt) * thrombus in the vein of interest * previous gsv treatment * pregnancy * known malignancy * significant arterial disease (ankle : brachial pressure index below 0•8) * use of anticoagulant medication.
n-3 enriched nutrition therapy and postoperative cognitive dysfunction after cardiac surgery

Conditions: Delirium, Dementia, Amnestic, Cognitive Disorders; Postoperative Cognitive Dysfunction

Summary: background: delirium and long-term cognitive dysfunction (cd) are important complications of major surgery and intensive care treatment. delirium is associated with increased mortality and cd has an important impact on mortality, independency, social interactions, and quality of life. delirium is an important risk factor for the development of long-term cd. particularly, patients aged 65 or older undergoing cardiac surgery are at a high risk of developing these problems. there are data suggesting that inflammation plays a key role in the development of delirium and possibly cd. it has been shown that n-3 fatty acids modulate the immune response of patients and have beneficial effects in abdominal surgery. working hypothesis: 1. administration of n-3 enriched nutrition therapy including will modulate the inflammatory response and improve cognitive function after cardiac surgery. specific aims: this project will test the impact of perioperative enteral n-3 fatty acids prosure, abbott nutrition) in elderly patients undergoing elective cardiac surgery. primary endpoint is cd one week postoperatively. methods: the investigators will investigate 400 patients aged 65 or older undergoing elective cardiac surgery. half of these patients will receive supplementary of n-3 fatty acids to modulate the inflammatory response; the other half will receive an isocaloric nutritional supplement without n-3 fatty acids (ensure plus, abbott nutrition). otherwise the treatment of the patients will not be influenced by this study. cognitive function will be assessed preoperatively, 7 days and three months postoperatively. c-reactive protein, il-6, il-8, il-10, s-100b, and neuron specific enolase will be monitored as markers of systemic inflammation and delirium.


Eligibility criteria:
inclusion criteria: * patient's undergoing elective cardiac procedure with extracorporeal circulation * age 65 or older exclusion criteria: * no informed written consent * "redo" operation * deep hypothermic cardiac arrest * operation including carotid endarterectomy * known allergy to n-3 fatty acids * history of cerebrovascular disease * preoperative mini mental score \< 23 * long term neuroleptic medication
all ligaments left in knee arthroplasty trial

Conditions: Primary Osteoarthritis of Knee Nos

Summary: compare the clinical and patient reported outcomes of the vanguard xp knee system to the vanguard cr knee system in patients with antero-medial osteoarthritis of the knee with an intact anterior cruciate ligament.

the purpose of the proposed allikat study (all ligaments left in knee arthroplasty trial) is to evaluate the early outcome of a total knee replacement device that retains both cruciate (vanguard xp) by comparing it with a control group of patients implanted with an established single cruciate retaining device (vanguard cr). the study also aims to examine short and long term descriptive cohort outcome data. a small preference cohort group of 60 patients receiving the vanguard xp knee system will be recruited alongside the rct group. this data will be used to confirm the external validity of the rct group and to contribute to the safety data for the british orthopaedic association's beyond compliance programme. evaluation will include intra-operative and post-operative complications, longer term survivorship and patient reported outcome measures.

Eligibility criteria:
inclusion criteria: * primary osteoarthritis of the knee involving one or more compartments of the joint. * intact anterior and posterior cruciate ligaments. * intact collateral ligaments. * correctable coronal deformity. * no more than 15 degrees of fixed flexion deformity. exclusion criteria: * age under 18 years. * revision knee replacement surgery. * rheumatoid arthritis. * traumatic aetiology. * history or clinical signs of acl rupture. * previous arthroscopy related to acl injury or reconstruction. * correction of a flexion contracture that may require extensive resection of distal femur. * altered pain perception and / or neurologic affection (for example as a complication arising from diabetes). * unable to consent for themselves. * patients with language or cognitive issues that may prevent them completing the follow up requirements. * contraindications for the device: * cementless application of components. * bmi ≥40 kg/m2. * use of anterior stabilized bearings. * patients with severe pre-operative varus or valgus deformity ≥ 15 degrees. * correction or revision of previous joint replacement procedure on index knee. * infection. * sepsis.osteomyelitis. * osteoporosis (requiring treatment). * relative contraindications include: * unco-operative patient or patient with neurologic disorders who is incapable of following directions. * osteoporosis. * metabolic disorders which may impair bone formation. * osteomalacia. * distant foci of infections which may spread to the implant site. * rapid joint destruction, marked bone loss or bone resorption apparent on roentgenogram. * vascular insufficiency, muscular atrophy, neuromuscular disease. * incomplete or deficient soft tissue surrounding the knee, including the anterior cruciate ligament.

Keywords: arthroplasty knee bicruciate retaining vanguard xp vanguard cr surgery zimmer biomet joint replacement osteoarthritis
a study to determine the prevalence of inflammatory dry eye disease in patients prior to cataract removal

Conditions: Dry Eye Syndromes

Summary: this study will evaluate the prevalence of inflammatory dry eye disease in patients prior to cataract surgery. no treatment is administered in this study.


Eligibility criteria:
inclusion criteria: * scheduled to undergo cataract removal surgery exclusion criteria: * current use of eye drops or oral medications for allergic conjunctivitis * serious ocular injury, intraocular surgery, or refractive surgery within 6 months in the study eye * use of a contact lens within 4 weeks
ispinesib in patients with advanced or metastatic non-small cell lung cancer

Conditions: Non-Small-Cell Lung Cancer

Summary: this study was designed to determine how effective and safe ispinesib is in treating locally advanced or metastatic non-small cell lung cancer in patients who have received a platinum-based chemotherapy and whose disease continues to progress. treatment involves a 1-hr treatment given intravenously (iv), repeated once every 21 days. a patient may continue treatment as long as they are benefiting from the treatment. blood samples will be taken at specific times over 24 hr period to measure the amount of drug in your body at specific times after the drug is given. blood samples will also be taken for routine lab tests such as complete blood counts and clinical chemistries. physical exams will be performed before each treatment.


Eligibility criteria:
inclusion criteria: * must have received only one prior platinum-based chemotherapy regimen. * blood tests will be done to check if blood counts are adequate for taking part in the study. exclusion criteria: * received more than 1 chemotherapy regimen in the past or have less than adequate liver and kidney function. * females who are pregnant. * any unstable, pre-existing major medical condition or history of other cancers. * have received an investigational drug, chemotherapy, radiation treatment or surgery within 28 days prior to entering the study.

Keywords: platinum-refractory platinum-relapsed non-small cell lung cancer
reliability of secondary caries detection around composite restoration using light induced fluorescence

Conditions: Secondary Caries

Summary: a total of 29 volunteer patients will be assigned in this study. each patient should have one resin composite restoration. the restoration will be evaluated by two diagnostic methods (d), where d1 represents visual-tactile assessment method (modified usphs) and d2 represents light induced fluorescence intraoral camera

three operators, the researcher and the 2 supervisors, from the conservative dentistry department, faculty of dentistry, cairo university, will be the examiners in this study. each examiner will record the dental findings using both the visual- tactile assessment method and the fluorescent-aided identification method. the visual-tactile assessment method includes the use of mirror, probe under good illumination condition, while the fluorescent-aided identification method will be performed by light induced fluorescence intraoral camera

Eligibility criteria:
inclusion criteria: * patients should be over 18 years of age. patients should have an acceptable oral hygiene level. patients must have at least one posterior resin composite restoration exclusion criteria: patients with a compromised medical history. severe or active periodontal disease. heavy bruxism or a traumatic occlusion.
6degrees vr system for treatment of phantom limb pain

Conditions: Pain, Phantom

Summary: the treatment system consists of two light-weight mymove bands and virtual-reality gear. built-in software allows tracking of performance in real-time, with feedback to both the patient and treating personnel. mymove is a wearable device that allows patients with loss of upper-limb function to operate computers, cellular phones, and similar devices. the technology is non-invasive and does not involve risk to the patient. mymove+ is a physical medicine and rehabilitation software intended for use in upper extremity and full-body conventional rehabilitation by: 1. tracking motion and movement kinematics. 2. guiding patients in the performance of physical exercises according to the treating practitioner's guidelines. mymove+ software is not intended for use in diagnosis, treatment or decision-making, or as a stand-alone device.

a non-blinded controlled study of adults, ages 18-65, with unilateral, below-knee limb amputation. all subjects will be initially evaluated by a single group of licensed physical- and occupational therapists. following a structured introductory session, subjects will be assigned to mymove devices and vr gear for a total of 10 sessions over a period of 5 weeks (15-20 minutes per session).

Eligibility criteria:
inclusion criteria: * clearance by the treating physician. * unilateral below-knee amputation * history of phantom-limb pain with an intensity of 5-or-greater (vas scale) * pain is not responsive to conventional drugs or other standard treatment. * range of motion (knee) of 10-to-90 degrees. exclusion criteria: * bilateral amputation * history of phantom-limb pain with an intensity of 4-or-less (vas scale) * no prior attempt at therapy * declined by patient * pregnancy or other limitation related to special health-care groups.

Keywords: phantom limb pain vas telerehabilitation
a comparison of monosyn and monocryl sutures in surgical wounds

Conditions: Wounds

Summary: to better understand surgeon preference when using synthetic, absorbable, monofilament suture by comparing two similar appearing fda-approved sutures, monosyn (aesculap) and monocryl (ethicon).

physicians have used suture to close wounds for at least 4,000 years. archaeological records from ancient egypt show that egyptians used linen and animal sinew to close wounds. in ancient india, physicians used the pincers of beetles or ants to staple wounds shut. they then cut the insects' bodies off, leaving their jaws (staples) in place. other natural materials used to close wounds include flax, hair, grass, cotton, silk, pig bristles, and animal gut. the fundamental principles of wound closure have changed little over 4,000 years. successful closure of wound involves surgical techniques coupled with knowledge of the physical characteristics and handling of the suture and needle. the selection of proper suture material in closing any surgical defect is important in wound healing, minimizing infection, and achieving optimal cosmetic and functional results. a great deal of progress has been made since egyptian times with regard to suture materials and manufacturing processes. today, sutures are available with a wide variety of characteristics, configuration, manipulability, coefficient of friction, solubility, strength, and immunogenic properties. yet, sutures are currently rather crudely classified based on a numeric scale according to diameter and tensile strength; descending from 10 to 1, and then descending again from 1-0 to 12-0. this study aims to explore the factors that are important to a surgeon when choosing sutures via evaluating surgeon preference for two types of synthetic, absorbable, monofilament sutures: monosyn and monocryl. we hope to initiate a more nuanced exploration of how suture characteristics influence surgeon preference, beyond filament type and size, and how makers of suture may better report and represent these factors.

Eligibility criteria:
inclusion criteria: * specific eligibility requirements included surgical defects that are linear, without curvature, 3.0 cm in length or greater and extending into the subcutis or fascia. * all surgical defects were required to be closed primarily (that is without flaps or grafts) and had equal skin integrity on both halves of their surgical defects. * all subjects were capable of providing written informed consent. exclusion criteria: * unable to provide written informed consent

Keywords: surgical wounds sutures
febrile urinary tract infection randomized short treatment trial

Conditions: Urinary Tract Infection

Summary: the purpose of this study is to determine whether a 7-day duration of antibiotic treatment of febrile urinary tract infection (futi) is non inferior to 14-day standard duration of treatment in unselected population presenting at primary care or emergency department.

in the last decades hospitalization rates of patients with acute pyelonephritis (ap) or futi has decreased from almost 100% to 10-30%. the outpatient management of patients with futi has become popular as well as oral antimicrobial treatment regiments and shortening of treatment duration. however, as such approaches are only discovered in otherwise young health non-pregnant women, the best management of futi in the elderly, men and patients with co-morbidity remains elusive. bases on personal perception of the attending physician antibiotic treatment, duration varies approximately between 7-14 days. facing the aging of the general population, it is urgent to better define the optimal treatment for ap or futi in an unselected population and to identify those at risk for treatment failure or poor outcome to guide and optimize individual patient management and to prevent on the one hand unnecessary long treatment duration and hospital admission and on the other hand unsafe short duration or unsafe outpatient management. in this study the efficacy and safety of a 7-day antimicrobial regimen compared to a 14-day antimicrobial regimen will be evaluated in an unselected population presenting with futi at primary care or emergency department. in addition a clinical and/or biomarker based scoring system of disease severity will be derived to predict those at risk for treatment failure or poor outcome.

Eligibility criteria:
inclusion criteria: * competent patient aged 18 years or above * one or more symptom(s) suggestive of urinary tract infection (dysuria, frequency or urgency\*; perineal or suprapubic pain; costo-vertebral tenderness or flank pain) * fever (ear or rectal temp of 38.2 oc or higher, or axillary temp of 38 oc or higher), or history of feeling feverish with shivering or rigors in the past 24 hours * positive urine nitrate test and/or leucocyturia as depicted by positive leukocyte esterase test or microscopy exclusion criteria: * known allergy to fluoroquinolones * female patients who are pregnant or lactating * patients with known polycystic kidney disease * patients on permanent renal replacement therapy (hemodialysis or peritoneal dialysis) * patients with history of kidney transplantation * residence outside country of enrolment * inability to speak or read dutch * isolated causal uropathogen resistant to ciprofloxacin * renal abscess * chronic bacterial prostatitis * suspicion or evidence of any metastatic infectious foci

Keywords: urinary tract infection fever acute pyelonephritis treatment duration febrile urinary tract infection treatment duration
inflammatory markers in preeclampsia

Conditions: Preeclampsia

Summary: this is an investigation of inflammatory markers in women destined to develop preeclampsia.


Eligibility criteria:
inclusion criteria: * caucasian origin exclusion criteria: * previous diseases e.g. cardiovascular disease, diabetes, hypertension, inflammatory bowel disease, serious organ disease

Keywords: pre-eclampsia inflammatory markers serological biobank to assess whether the inflammatory markers could be useful in order to identify pregnant women at risk to develop preeclampsia
emergency classification according to fingertip circulation

Conditions: Dyspnea

Summary: dyspnea is one of the most common reasons for admission to the emergency department\[1\]. oxygen saturation has great importance in determining the triage status of patients admitted to the hospital with dyspnea and planning the emergency treatment \[2\]. peripheral perfusion index (pi), which shows tissue oxygenation is a noninvasive way of demonstrating tissue perfusion in critically ill patients. studies have shown that pi is an accurate, fast and reliable pulse oximetry-based indicator of tissue perfusion \[3-5\]. pi shows the perfusion status of the tissue in the applied area for an instant and a certain time interval. the pi value ranges from 0.02% (very weak) to 20% (strong) \[6\]. triage scales are used to distinguish emergency and non-emergency patients. the emergency triage system is used to quickly determine the care priorities of patients during admission to the emergency department\[7,8\]. it is important to make the triage classification for dyspnea in emergency services quickly and accurately to start the treatment protocols as early as. in this study, the investigators aimed to determine the relationship between perfusion index and the emergency triage classification in patients admitted to the emergency department with dyspnea.

purpose: to determine the effect of pi measurement on the emergency triage classification in patients with dyspnea. methods: adult patients who presented with dyspnea and whose perfusion index values were measured with masimo radical-7 device at the time of admission, at the first hour and the second hour of admission were included in the study. the pi and oxygen saturation measured by finger probes were compared and the superiority of their effects on the emergency triage classification was compared.

Eligibility criteria:
inclusion criteria: * adult patients over the age of 18 who presented with dyspnea * whose perfusion index values were measured at the time of first admission (arrival time), at the first hour and the second hour of admission were included in the study exclusion criteria: * patients who applied due to the mechanism of trauma, * patients with known vascular disease (buerger's disease, peripheral artery disease, etc.), -patients with covid-19 pcr positivity * whose perfusion index measurement could not be completed due to hospitalization or discharge were excluded from the study.

Keywords: dyspnea emergency perfusion index triage
investigation of drug-drug interaction of nintedanib and ketoconazole in healthy male volunteers

Conditions: Healthy

Summary: the objective of the current study is to investigate the relative bioavailability of a single dose of nintedanib low or high dose with and without coadministration of ketoconazole at steady state


Eligibility criteria:
inclusion criteria: 1. healthy male subjects exclusion criteria: 1. any relevant deviation from healthy conditions
evaluation of the efficacy of cesamet™ for the treatment of pain in patients with diabetic peripheral neuropathy

Conditions: Diabetic Neuropathies

Summary: this study was designed to evaluate the safety and efficacy of cesamet™ in controlling pain in subjects experiencing pain due to diabetic peripheral neuropathy.

the purpose of this study is to determine the safety and efficacy of cesamet™ in the symptomatic treatment of pain due to diabetic peripheral neuropathy. this is a phase iv, multi-center, open label outpatient clinical trial evaluating cesamet™ treatment for control of pain due diabetic peripheral neuropathy. the study has two phases: a pretreatment phase and a treatment phase.

Eligibility criteria:
inclusion criteria: * patients with diabetic peripheral neuropathic pain * chronic daily pain present for at least 2 months * on stable analgesic regimen for one month * baseline pain score greater than 40mm on a visual analog scale exclusion criteria: * hypersensitivity to compounds in study drug or similar drugs * pregnant or lactating females * drug or alcohol abuse * unstable medical condition