Kornimate/medical-research-clean huggingface dataset:
preventing catheter-associated urinary tract infections with a virtual simulation game

Conditions: Catheter-Associated Urinary Tract Infection; Nurse's Role

Summary: objective: the purpose of this study was to investigate the effectiveness of a virtual simulation game in improving nursing students' knowledge and abilities in preventing catheter-associated urinary tract infection (cauti). method: the study was designed as a parallel-group, randomized controlled trial. a pre-test on knowledge and abilities will be administered to all students participating in the study. following the pre-test evaluation, a training session on "cauti prevention" will be held. the present training approach (lecture method) in the curriculum will be employed in this session. following the training, the students in the sample group will be randomly divided into the experimental group (students using virtual simulation game application) and the control group (students learning with the existing education method) based on their general weighted grade averages using the stratified randomized approach. the experimental group will play the virtual simulation game for seven days. knowledge and competence assessments (post-test) of the control and experimental groups will be conducted seven days following the training. the virtual simulation game application will be evaluated by the students in the experimental group after the post-test evaluations. the students' positive, negative, and constructive feedback on the virtual simulation game will be solicited during the assessment. in addition, these students will score in a 5-point likert type to evaluate the statements about the virtual simulation game. hypothesis: h0-1: there is no difference in knowledge about preventing cauti between students using the virtual simulation game method and students in the control group. h1-1: there is a difference in knowledge about preventing cauti between students using the virtual simulation game method and students in the control group. h0-2: there is no difference in cauti prevention skills between students using the virtual simulation game method and students in the control group. h1-2: there is a difference in cauti prevention skills between students using the virtual simulation game method and students in the control group.


Eligibility criteria:
inclusion criteria: * to be enrolled in nursing profession courses practice-ii for the first time * to agree to participate in the study * to have internet access and smartphone or computer exclusion criteria: * not filling in the data collection forms of the research at any stage * answering the data collection forms of the research incomplete * not having received the first or last skill assessments * not attending the training on preventing cauti * not playing/completing the virtual simulation game

Keywords: virtual simulation game catheter-associated urinary tract infection nursing education nursing students
distance healing in wound healing

Conditions: Breast Reconstruction Surgery

Summary: this trial examines the impact of patients' knowledge of an experienced distant healer's efforts to heal them on measures of wound healing, psychosocial functioning, and physiological symptoms after plastic surgery.


Eligibility criteria:
inclusion criteria: * women undergoing major plastic surgery (\> 2 hours in length) * health status is excellent with no systemic disease, no limitation on activity, no danger of death or disease of one body system, well-controlled underlying disease exclusion criteria: * remove history of breast or other cancers * history of radiation therapy to the abdomen or any radiation within the past three months * non-english speaking * unable or unwilling to fill out questionnaires * current smoker * morbid obesity * circulatory inadequacies (i.e., diabetes, hypovolemia) * nutritional deficits as evidenced by neutropenia (wbc \<2500/ml) or hypoalbuminemia (albumin \<3.3mmg/dl) / chart review

Keywords: breast reconstruction surgery prayer distance healing wound healing
relationship between dopamine genetics, food reinforcement, energy intake and obesity

Conditions: Obesity

Summary: the purpose of the study is to determine whether the presentation of various foods produces an increase or decrease in responses on a motivational computer task. in addition, the study determines if energy intake or motivation to obtain food is related to the dopamine receptor genotype.

one of the most important research areas in obesity is developing a better understanding of individual differences in factors that influence excess energy intake and positive energy balance. one key to understanding these individual differences is determining what factors underlie the motivation to eat. we have demonstrated in a series of studies that obese adults and children are more motivated to work for palatable, favorite foods than leaner peers and that those high in food reinforcement consume more food in an ad libitum eating task than those who do not find food as reinforcing. dopamine (da) is one of the major neurotransmitters involved in establishing the reinforcing value of food, and low levels of dopamine activity and a reduction in the number of da receptors is associated with obesity. the general aim of the proposed research is to build upon this research to examine relationships between food reinforcement, obesity, and polymorphisms of genes within the dopaminergic system.

Eligibility criteria:
inclusion criteria: * non-smokers * 18-50 years of age * no known eating disorder * moderate liking for study foods * no current diagnosis of psychiatric disorder (e.g., anxiety or depression) * not on medications that would interfere with appetite (e.g., methylphenidate) or dopaminergic activity * non-diabetics exclusion criteria: * smoker * pregnant women * current diagnosis of a psychiatric or eating disorder * dietary restrictions that would interfere with participation * on medications that could interfere with appetite or olfactory responsiveness or use of antidepressants or any medication or dietary supplement that could affect appetite or dopaminergic activity * excessive use of alcohol (\>21 drinks/week), alcoholism,current addiction to opiates, cocaine or stimulants

Keywords: food reinforcement energy intake obesity dopamine
a randomized, placebo controlled study to determine the efficacy and speed of a nasal spray in allergen induced seasonal allergic rhinitis

Conditions: Seasonal Allergic Rhinitis

Summary: finding out how fast azelastine nasal spray works in subjects with hay fever.


Eligibility criteria:
inclusion criteria: * history of seasonal allergic rhinitis to ragweed pollen for last 2 consecutive seasons; * positive response to skin prick test to ragweed allergen at screening; * be willing to participate in the trial. exclusion criteria: * history of hypersensitivity to azelastine; * females who are pregnant or lactating; * relative chronic sinusitis or nasal structural abnormalities causing greater than 50% obstruction; * asthma that requires other than occasional use of inhaled short-acting beta-2 antagonist; * known non-responsiveness to antihistamines; * alcoholism or drug abuse within 2 yrs. of screening; * current or regular use within 6 months of any type of tobacco product; * evidence of any clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic or malignancies within the last 5 years; * history of a positive test to hiv, tb, hepatitis b or c.

Keywords: seasonal allergic rhinitis ragweed pollen allergy
effect of calcitriol on neutrophil to lymphocytes ratio and high sensitivity c-reactive protein covid-19 patients

Conditions: COVID-19

Summary: this research is a study that compares the administration of calcitriol with the outcomes of covid-19 patients

this research was an observational analytic cohort retrospective study in which the subjects were moderate degree covid-19 inpatients in sebelas maret university hospital divided into two groups. the control group received standard therapy, while the treatment group received calcitriol 2x400 iu per day.

Eligibility criteria:
inclusion criteria: * covid-19 patients, hospitalized patients, and patients aged 18-60 years exclusion criteria: * pregnancy

Keywords: calcitriol, hscrp
prospective multicenter randomized and controlled study evaluating the benefit of early pulmonary vein isolation compared to usual treatment in patients aged over 75 years and presenting with atrial fibrillation

Conditions: Atrial Fibrillation

Summary: therapeutic management of atrial fibrillation (af) is based either on heart rate control or on rhythm control, a strategy which aims to maintain a normal heart rhythm. the benefit in terms of morbidity and mortality of a normal heart rhythm would, however, be largely offset by the frequent side effects of antiarrhythmic drugs which could even lead to an increase in mortality compared to rate control. this increase has particularly been suggested in people aged over 75. since the emergence of catheter pulmonary vein isolation (pvi), an effective alternative to antiarrhythmic drugs has become available. this technique makes it possible to isolate the foci triggering af under local or general anesthesia with greater effectiveness than medications and very low risks. records in the elderly do not seem to show a reduction in effectiveness or an increase in complications. however, in the absence of a dedicated randomized study, its use is strongly limited in the elderly where rate control (52% of people over 65 years old) and the use of antiarrhythmic drugs are largely favored due to the simplicity of implementation and the low cost of medications. however, an early rhythm control strategy seems to reduce cardiovascular events in relatively old individuals (average age 70 years). the use of pvi in first line could make it possible to further improve these results. the objective of the investigator is therefore to carry out the first randomized comparative study proposing to evaluate the impact of early pvi compared to usual treatment in patients aged 75 and over with af.


Eligibility criteria:
inclusion criteria: * man or woman aged 75 and over. * paroxysmal af or early recurrent or persistent paroxysmal af first diagnosed less than 12 months ago. * patient who consented to participate in the study. * patient affiliated to a social security system. exclusion criteria: * indication of cardiac pacing or defibrillation at baseline. * history of valve replacement, atrial occlusion or exclusion. * history of af ablation. * contraindication to anticoagulation or an invasive procedure. * significant heart disease (structural with alteration of lvef \<35%, congenital heart disease, hypertrophic heart disease with wall of more than 15 mm, revascularized coronary syndrome less than 3 months old). * stroke less than 6 months old. * uncontrolled dysthyroidism. * chronic renal failure (ckd - egfr \<30 µmol/l). * patient under curatorship, guardianship, safeguard of justice. * life expectancy less than 24 months. * participation in another therapeutic trial likely to impact the study evaluation criteria. * severe cognitive impairment noted in history. * lack of understanding of the study.

Keywords: atrial fibrillation pulmonary vein isolation elderly conventional management frailty
social determinants of migrant health factors impacting prostate cancer care and survivorship among sub-saharan african and caribbean immigrant men

Conditions: Prostate Carcinoma

Summary: this study is being done to understand what social factors affect health decisions for those who have immigrated from another country by examining how the immigration from sub-sahara africa affects the experiences of participants regarding health-seeking behaviors, care, and treatment of prostate cancer. it also examines similarities and differences among participants based on their region of origin in africa.

primary objective: i. to employ the social determinant of migrant health framework (international organization for migration, n.d.) to examine the impact of immigration on the health-seeking behaviors of ssai including informed-decision making, psychosocial effects and coping mechanisms. (phase i) ii. to examine sdomh factors among ssai and ci men, including their migration experience and health behaviors. (phase ii) outline: this is an observational study. aim i: participants complete a survey and participate in an interview in person, over the phone, or via zoom on study. aim ii: participants complete an interview in person, over the phone, or via zoom on study.

Eligibility criteria:
inclusion criteria: * phase i: * adult men originally from each of these geographic regions (east, west, central, and southern africa) and have been diagnosed with prostate cancer * able to provide written consent and conduct an interview * able to speak and understand english * phase ii: * caribbean immigrant men and ssai men diagnosed with cap within the last 10 years who identify as black and speak english * able to provide written consent and conduct an interview * able to speak and understand english exclusion criteria: * phase i: * patients below the ages of 18, and those not belonging to any of four regions * employees of mayo clinic will be excluded * non-english speakers will not be included * phase ii: * individuals below the age of 18 * those not diagnosed with prostate cancer and individuals not from the regions described above * employees of mayo clinic will be excluded * non-english speakers will not be included
a clinical risk score to predict bloody stool in neonates

Conditions: Bloody Stool; Necrotizing Enterocolitis

Summary: bloody stool is a main focus in non-neonatal intensive care unit ward, and it is one of the risk factors in neonates with subsequent necrotizing enterocolitis(nec) and usually lead to longed duration of hospitalization. nec is one of the most serious disease in the newborn infants, and two and more grades of nec might lead to surgery, even death. but, it is difficult to predict when the bloody stool comes and develop to two and more grades of nec.

nec is characterized by vomit, abdominal distention, hypoactive bowel sounds and bloody stools, even shock, disseminated intravascular coagulation(dic) and sepsis. x-ray is shown intestinal wall gas and/or portal vein pneumatosis and pneumoperitoneum. bloody stool in newborn infant is a urgent condition, and neonatologist usually need to predict whether or not two and more grades of nec it is. here, the investigators will develop a score system in one retrospective cohort to predict bloody stool, and the score system is validated in another prospective cohort.

Eligibility criteria:
inclusion criteria: * more than or equal to 35 weeks' gestational age(ga) * less than or equal to 28 days * non-neonatal intensive care unit ward exclusion criteria: * parents' rejection * main congenital malformation
oral ds107 in moderate to severe atopic dermatitis

Conditions: Atopic Dermatitis

Summary: this study will compare the safety and efficacy of oral ds107 (2 g) to placebo in patients with moderate to severe atopic dermatitis. oral ds107 (2 g) will be orally administered for 8 weeks, and will be compared against placebo. this study will enroll approximately 100 adult patients.

subjects will come to the clinic on 6 occasions: at screening, baseline, week 2, week 4, week 8 (end of treatment/early termination) and week 10 (follow-up). the primary efficacy variable will be the iga. secondary efficacy variables will include iga (investigator's global assessment), scorad (scoring atopic dermatitis) visual analog scale (vas), easi, bsa (body surface area), poem (patient orientated eczema measure), dlqi (dermatology life quality index).

Eligibility criteria:
inclusion criteria: * male or female subject aged 18 years and older. * moderate to severe atopic dermatitis. exclusion criteria: * clinically significant impairment of renal or hepatic function. * history of hypersensitivity to any substance in oral ds107 or placebo capsules. * treatment with any experimental drug within 30 days prior to day 0 visit (baseline). * excessive sun exposure, use of tanning booths or other ultraviolet (uv) light sources and/or is planning a trip to sunny climate.
icg-based fluorescence imaging in localization of prostate cancer and metastatic lymph nodes

Conditions: Prostate Cancer

Summary: this study aims to evaluate the feasibility of indocyanine green (icg)-based fluorescence imaging in the detection of prostate tumors and metastatic lymph nodes. by correlating the icg fluorescence patterns with pathologically confirmed tumor and nodal status, it would be possible to use fluorescence navigation system in helping prostate biopsy and lymph node dissection in the future.

the investigators will conduct an in vivo and in vitro pilot study in order to evaluate the diagnostic performance of fluorescence in the detection of prostate cancer and metastatic lymph nodes. all the patients included in this study will receive a radical prostatectomy after intravenous injection of 0.4 mg/kg of icg. icg will be administered immediately after the patient is anesthetized. the fluorescence analysis will be performed intraoperatively by laparoscopic imaging and after surgery by hand-held imaging. the prostate or lymph nodes specimen with or without fluorescence signal will be sent to the department of pathology for pathological analysis. the histopathological procedure will be performed without knowledge of fluorescence analysis.

Eligibility criteria:
inclusion criteria: * histologically confirmed prostate cancer; * able to accept total prostatectomy; * patient has given its informed consent. exclusion criteria: * allergic to icg or iodine; * high-grade hepatic insufficiency * refuse attending the study

Keywords: icg prostate cancer
biorepository to support research in kidney diseases

Conditions: Acute Kidney Injury; Acute Interstitial Nephritis; Kidney Diseases

Summary: to support advances in the understanding of pathophysiology and therapies of kidney diseases by creating a biobank of kidney tissue, dna, plasma, and urine from patients with kidney diseases.

a biorepository of human samples to support research to advance understanding of human kidney diseases will be created. clinically, kidney diseases are detected by blood and urine laboratory tests. however, the underlying cause of kidney disease is often not clear on blood and urine tests. in such cases, a clinician may choose to perform a kidney biopsy to establish the diagnosis. patients who are scheduled to undergo a kidney biopsy will be invited to participate in this proposed study.

Eligibility criteria:
inclusion criteria: * patients scheduled to undergo a clinically indicated kidney biopsy * english or spanish speaking exclusion criteria: * under 18 years or age * known pregnancy * additional vulnerable individuals (incarcerated, institutionalized, or otherwise unable to participate in the study) * inability to provide informed consent

Keywords: kidney kidney disease acute kidney injury kidney biopsy kidney biorepository
safety and performance evaluation of multiplus dialysate during crrt

Conditions: Acute Kidney Injury

Summary: assessment of the performance of multiplus dialysate based on the serum creatinine removal 6 hours (360 min) after start of continuous veno-venous haemodialysis/ haemodiafiltration \[cvvhd(f)\]. multiplus is a phosphate-containing dialysis solution for the use in continuous renal replacement therapy (crrt) during acute kidney injury (aki).


Eligibility criteria:
inclusion criteria: * signed and dated informed consent form by investigator and by * a) the study patient: if patient is able to consent * b) the legal representative: if patient is unable to consent: * c) an independent consultant: in case of emergency * if c) either legal representative or study patient, whichever can be done sooner, should be informed by the investigator as soon as possible. if the informed consent has been obtained by the legal representative (b or emergency scenario) informed consent to continue the participation in the clinical investigation shall be obtained from the subject as soon as he or she is capable of giving informed consent (according to the mdr - article 68 - clinical investigations in emergency situations) * minimum age of 18 years * ability to understand the nature and requirements of the study (if patient is conscious) study specific: * body weight greater than 40 kg * acute kidney injury (aki) with clinical indication for cvvhd/cvvhdf * vascular access allowing blood flow of min 50ml/min * estimated life expectancy greater than 3 days exclusion criteria: * any conditions which could interfere with the patient's ability to comply with the study * in case of female patients: pregnancy (negative pregnancy test for women below 55 years) or lactation period * participation in an interventional clinical study during the preceding 30 days * previous participation in the same study * sars-cov 2 positive study specific * hyperphosphataemia (\>4.5 mg/dl) * hypersensitivity to heparin or known history of heparin induced thrombocytopenia (hit type ii) * uncontrolled bleeding and coagulation disorders * decision to limit therapeutic interventions * advanced malignancy (not including myeloma) * dementia (if definitely not an acute confusional state from uraemia or other acute illness) * advanced cirrhosis with encephalopathy in the absence of possible liver transplantation

Keywords: renal replacement therapy acute kidney injury haemodialysis haemodiafiltration
the effectiveness of diode laser 980-nm in iraqi face hemangioma: a randomized within patients trial

Conditions: Hemangioma

Summary: in an academic, government clinic, uni-center, randomized within patients trial study of the effects of 980-nm diode laser treatment included 15 cases of facial hemangiomas in patients with a history of discomfort due to lesions that were not suitable for removal using traditional methods. the study was carried out at the university of baghdad/institute of laser for postgraduate studies/laser medicine research clinics from 15 october 2018 to 15 april 2019. primary end-point is improvement of conditions at 6 months. secondary end-points are quality of life, disappear lesions and safety administration of diode laser. each patient received 12 sessions at two-week intervals. lesions were photographed before and after laser treatment and digital image histograms were generated as a graphical representation of the tonal distribution. following treatment, the lesions were less elevated, smoother in texture, and the color changed from dark red to light pink. there is a need to improve the treatment of face hemangiomas. results from this randomized within patient trial will serve as preliminary evidence of the future role of diode laser in hemangioma treatment and a basis for design and power estimations of future studies. based on the skin texture, color and elevation of the hemangioma as well as patient satisfaction, this type of laser is a safe and effective modality for the treatment of facial hemangioma in iraqi patients.


Eligibility criteria:
inclusion criteria: 1. comfortable. 2. superficial lesion. exclusion criteria: 1. advanced case. 2. deep lesion. 3. uncomfortable.

Keywords: hemangioma randomized within patient diode laser histogram