Kornimate/medical-research-clean huggingface dataset:
sub-occipital mit with and without hr agonist contraction of hamstrings in neck pain patients with hamstring tightness

Conditions: Neck Pain Patients With Hamstring Tightness

Summary: hamstrings and sub occipital muscles are part of the superficial back line of the myofascial chain which connects the neck to the lower extremity and the soft tissue in the cervical spine links the dura and sub occipital muscle fascia. increased tension in one or other part of this myofascial chain disturbs the whole superficial back line and compromises the flexibility. the objective of this study is to determine the effects of sub-occipital muscle inhibition technique (mit) with and without hold relax (hr) agonist contraction of hamstrings on pain, disability and craniovertebral angle in neck pain patients with hamstring tightness. this study will be a randomized controlled trial and will be conducted in physiotherapy center of al-mahmood welfare foundation sahiwal. this study will be completed in time duration of 10 months after the approval of synopsis and consecutive sampling technique will be used. a sample size of 34 will be randomly assigned into two groups. group a will be given sub occipital muscle inhibition treatment while group b will be given sub occipital muscle inhibition and hold relax agonist contraction of hamstring. each group will be given three sessions per week. data will be collected from all participants before first session of treatment and after 6th session of treatment by using numeric pain rating scale (nprs), neck disability index (ndi), cervical range of motion (crom), craniovertebral angle (cva) and active knee extension (ake) test measurement.


Eligibility criteria:
inclusion criteria: age 25-40 years both genders ( male and female) neck pain on nprs ≥5 ndi score ≥14 ( moderate disability) active knee extension lag ≥30 and considered as tight hamstrings exclusion criteria: acute low back or neck pain history of lumbar and cervical herniated disc and spinal stenosis history of cervical spine surgery and trauma history of vascular disease in head and neck progressive neurological deficit or inflammatory condition ( such as peripheral neuropath, rheumatoid arthritis) history of abdominal or pelvic surgery in last 6 months

Keywords: hamstring muscles neck pain muscle tightness pnf stretching range of motion
decision making support for parents and caregivers

Conditions: Neonatal Critical Illness; Pediatric Critical Illness

Summary: the purpose of this study is to test the feasibility and acceptability of a tool to support decision making for parents of critically ill infants.

in this single-arm mixed methods prospective feasibility study, we will enroll infants, parents, and clinicians. the intervention is a paper-based decision guide that contains a values clarification exercise and question prompt list.

Eligibility criteria:
study participants will include english-speaking parents of critically ill infants and children admitted to duke university hospital. infant inclusion criteria will include 1. age \< 1 year, 2. admission to a critical care unit, and 3. an anticipated serious health care decision all parents of eligible infants will be considered for inclusion. parent exclusion criteria will include 1) age \< 18 years, 2) hearing or speech impairment, and 3) non-english speakers. all clinicians of eligible infants will be considered for inclusion.
a survey to evaluate the rate of abnormal glucose tolerance among hong kong chinese subjects with coronary heart disease

Conditions: Coronary Heart Disease; Diabetes Mellitus

Summary: hypothesis: there is a high prevalence rate of diabetes, including asymptomatic undiagnosed glucose intolerance, among subjects with coronary heart disease in hong kong. a cross-sectional survey is planned to study the rate of undiagnosed diabetes and glucose intolerance among the chinese patients with coronary heart disease in hong kong. the survey results will be important for us to plan the logistics to investigate and manage the potential glucose abnormality of our heart disease patient.

diabetes is becoming an epidemic in hong kong, affecting over 10% of population and causing a major burden to the health care system. over 30-40% of patients admitted to the medical wards of the hospital authority hospitals have diabetes as a contributory factor. it was estimated that thirty to fifty percent of patients with stroke, heart failure or acute myocardial infarction have diabetes as a key causative factor. however, the exact prevalence rate of diabetes, including asymptomatic undiagnosed glucose intolerance, among subjects with coronary heart disease is still unknown in hong kong. many heart disease patients with undiagnosed diabetes remained being untreated on their abnormal glycemic status, which will further aggravate the heart disease and impair the prognosis. the investigators plan to conduct a cross-sectional survey to study the rate of undiagnosed diabetes and glucose intolerance among the chinese patients with coronary heart disease in hong kong. the survey results will be important for us to plan the logistics to investigate and manage the potential glucose abnormality of our heart disease patient.

Eligibility criteria:
inclusion criteria: 1. patients aged 18 years 2. subjects admitted to hospital authority hospital as in-patients (ahnh) with the diagnosis of coronary heart disease (icd code 410-414) during the period 1 april 2007 to 31 march 2008. 3. subjects admitted to ahnh for the procedure percutaneous coronary intervention (pci) to manage coronary heart disease. exclusion criteria: 1. known type 1 diabetes defined as history of ketosis \[acute symptoms with heavy ketonuria (\>3+) or ketoacidosis\] or heavy ketonuria (3+) or continuous requirement of insulin treatment within one year of diagnosis and thereafter. 2. patients with terminal malignancy or other life-threatening diseases with less than 6-month expected survival 3. patients with a mental condition rendering the subject unable to understand the nature, scope, and possible consequences of the study
diagnostic and imaging indicators of immunocardiomyopathic patients

Conditions: Autoimmune Diseases

Summary: cardiac involvements in autoimmune diseases (ad) is common but underestimated and an early detection remains a clinical challenge for lacking of efficient imaging methods. the objective of the study was to investigate lv myocardial abnormalities in ad patients by multimodal cardiac imaging, including speckle-tracking echocardiology (ste), cardiac magnetic resonance imaging (cmri) and positron emission tomography (pet).


Eligibility criteria:
inclusion criteria: * patient is diagnosed with autoimmune diseases, including systemic lupus erythematosus (sle), vasculitis, dermatomyositis, sjogren's syndrome, scleroderma, rheumatoid arthritis and igg4 associated disease. * patient is capable of complying with study procedures exclusion criteria: * patient is pregnant or nursing * patient is complicated with congenital heart disease * patient had cardiac surgery before * patient is complicated with serious infections * patient is complicated with organ failure * patient is complicated with tumors * patient is diagnosed indefinitely * patient has been involved in other clinical trial
goal directed fluid therapy and postoperative ileus

Conditions: Postoperative Ileus

Summary: despite goal directed fluid therapy (gdft) has shown a reduction of hospitalization and overall complications in patients undergoing abdominal surgery, there is a need to address the effect of implementing gdft on the incidence of specific surgical complications and in a context of en enhanced recovery program (erp). specifically, studies investigating the impact of gdft on primary postoperative ileus (poi) in patients undergoing laparoscopic colorectal surgery and using an erp are missing. it is hypothesized that the incidence of primary poi will be reduced in patients receiving intraoperative gdft compared to patients receiving standard fluid therapy (sft) after elective laparoscopic colorectal surgeries with an erp program.

randomized controlled trial. study population: elective laparoscopic colorectal resections with an enhanced recovery program (erp) sample size: 128 patients (140 accounting for drops out) two arms: gdft: patients will receive gdft esophageal doppler guided; sft: patients will receive sft based on standard anesthesia formula and international guidelines to calculate fluid requirements. study hypothesis: the incidence of primary poi will be reduced in patients receiving intraoperative gdft compared to patients receiving sft after elective laparoscopic colorectal surgeries with an erp program. erp: all patients will receive the same perioperative care according to the enhanced recovery after surgery eras® program guidelines. intravenous fluid will be stopped the first day after surgery. patients will be allowed to have clear fluids the same day of surgery and diet, as tolerated, the first day after surgery.

Eligibility criteria:
inclusion criteria: * all patients undergoing elective laparoscopic colorectal resection with an enhanced recovery program exclusion criteria: 1. age \<18 yr 2. emergency surgery 3. patients who do not understand, read or communicate in either french or english 4. patients who had undergone esophageal or gastric surgery 5. esophageal pathology (esophageal varices or cancer) 6. patients with coarctation of the aorta or aortic stenosis 7. chronic atrial fibrillation 7. preoperative bowel obstruction 8. coagulopathies 9. chronic use of opioids
a study of the safety, pharmacokinetics, pharmacodynamics, and immunogenicity of anti-abeta (mabt5102a) in patients with alzheimer's disease

Conditions: Alzheimer's Disease

Summary: this is a phase i, multicenter, randomized, double-blind, placebo-controlled study that will be conducted in the united states and consists of a single ascending-dose stage followed by a multidose, parallel-treatment stage. this study will be conducted in approximately 50 adult patients between 50-85 years old who have mild to moderate alzheimer's disease.


Eligibility criteria:
inclusion criteria: * diagnosis of probable ad according to the nincds-adrda criteria * approved ad treatments (ache inhibitors+/-memantine) must be stable for ≥ 3 months prior to screening * other prescription medications must be stable for ≥ 1 month prior to screening exclusion criteria: * female patients with reproductive potential * history or presence of any clinically significant cns disease * history of treatment with any protein therapeutic targeting abeta

Keywords: ad alzheimer's alzheimers
afatinib genomic landscape

Conditions: Carcinoma, Non-Small-Cell Lung; Non-Small Cell Lung Cancer; Non-small Lung Cancer

Summary: the investigators propose to conduct a pilot feasibility study of single agent afatinib in patients with previously untreated metastatic egfr (epidermal growth factor receptor) mutant adenocarcinoma of the lung (nsclc = non-small cell lung cancer) with the sole purpose of characterizing the genomic landscape before afatinib and at the time of disease progression.

the current proposal will include exome and transcriptome sequencing from blood collected at baseline along with tumor samples obtained prior to starting afatinib and at the time of disease progression (a total of two tissue samples and one blood sample per patient). the samples will be collected via consent to the irb (institutional review board) approved banking study "tissue and blood acquisition for genomic analysis and collection of health information from patients with thoracic malignancies, suspected thoracic malignancies, or mesothelioma". if carried out successfully, the proposed strategy very likely will lead to a larger and adequately powered study (perhaps using whole genome sequencing) to understand fully evolving molecular changes due to clonal selection under treatment pressure. the pace of progress in the field of sequencing technology currently underway is only likely to accelerate in the near future yielding richer and highly content-rich information. moreover, it is likely that genomic information from dna sequencing and transcriptome will be supplemented by analyses of translatomes and proteomes. successful completion of the proposed study would enable future studies to fully harness the potential of emerging technologies to develop novel approaches to treat and even ideally prevent resistance to egfr tkis (tyrosine-kinase inhibitor) and other molecularly targeted therapies. this could serve as a template for other cancer types as well. over time, this approach, broadly used, would create simultaneously, highly valuable annotated tumor specimens along with germ line dna for high-throughput genomic studies to identify novel targets and their impact on the course of disease. re-analyzing molecular changes in the tumor at the time of disease progression would likely be a new standard of care to guide salvage therapy.

Eligibility criteria:
inclusion criteria/exclusion criteria: * diagnosis of metastatic stage iiib/iv lung adenocarcinoma * presence of known sensitizing mutations in egfr tk domain (exon 19 deletion and l858r) * absence of known resistant mutations in the egfr tk domain (t790m) * consented to hrpo # 201305031 ("tissue and blood acquisition for genomic analysis and collection of health information from patients with thoracic malignancies, suspected thoracic malignancies, or mesothelioma") * no prior treatment for this malignancy * no prior localized therapy to the biopsy site * planned treatment with standard of care afatinib at 40 mg qd (daily) * not pregnant or breastfeeding * at least 18 years of age
influence of implant crown transmucosal contour design on soft and hard tissue clinical outcomes

Conditions: Gum Disease

Summary: this study will evaluate how the crown's shape under the gums will influence the gum tissue around dental implants.

this research is studying the transmucosal contour, or shape of crowns (white-colored tooth structure that sits above the gum) under the gums on dental implants. participants will be randomly selected for the dental implant crown to be designed with either a straight or concave transmucosal contour, and followed up on for 1 year after crown delivery.

Eligibility criteria:
inclusion criteria * be a current participant of hum00208140 main study * have a dental implant that is ready to be restored (placed at least 3 months ago and healing is adequate) exclusion criteria: • the dental implant crown was already delivered.
influence of a modified ramadan fasting on health and well-being in healthy muslims - a randomised controlled trial

Conditions: Healthy Volunteers

Summary: in this study the investigators will test the impact of a modified ramadan fasting regimen on health and well-being. the 2016 ramadan is around summer solstice in germany making it one of the most challenging fasting periods for participating muslims. the modified ramadan fasting consists of educational components around fasting, and advice for nutritional modifications in order to support health and well-being during ramadan, while the control group will continue to fast as usual. the investigators will measure not only body weight/fat but also include measures of psychological well-being, and spiritual practice, and serum markers for blood lipids, and blood sugar. with this trial the investigators aim to determine, whether such modifications around ramadan will be beneficial for health and well-being.

see above

Eligibility criteria:
inclusion criteria: * healthy muslims participating in ramadan fasting * no first time fasting exclusion criteria: * untreated or malign hypertension * eating disorder * psychological disorder (e.g. depression, schizophrenia, addiction) * co-morbid disease (e.g. diabetes, cancer, gout) * pregnancy * breastfeeding women * bmi under 20 or above 40 * recently on a diet

Keywords: ramadan fasting nutrition quality of life
transcutaneous tibial nerve stimulation for spinal cord injury neurogenic bladder

Conditions: Spinal Cord Injuries

Summary: the purpose of this study is to determine if electric stimulation to the leg, called transcutaneous tibial nerve stimulation (ttns), can improve bladder outcomes in acute spinal cord injury.

the purpose of this study is to see how well ttns works at preventing incontinence in people with paraplegia from sci that perform intermittent catheterization to empty their bladder. this study will compare the effectiveness of ttns at 2 doses, fixed-dose and variable-dose. it will also evaluate the frequency of use, 2 days weekly compared to 5 days weekly. based on our pilot trials, tibial nerve stimulation protocols use submotor current intensity with a duration of 200 µs and a frequency of 20hz. the experimental group will use a submotor "variable dose." the fixed-dose group will use submotor at current intensity at 1ma and designated as "fixed-dose." ttns will be used 5 days weekly, per our pilot trial. at 4-months post-sci, the subject will be instructed to switch to 2x daily if he or she was randomized into the variable dose group of 2 days weekly and thus continue to doing so for the remainder of study participation. because there is support in the literature for reduced doses of tibial nerve stimulation required for maintenance (1-3x weekly), the rct includes this frequency comparison arm. all subjects will continue for 1-year post-sci. additionally, we are collecting surveys to help identify characteristics of people (resilience and confidence) and adherence to medication and ttns use throughout the study.

Eligibility criteria:
inclusion criteria: * 18-75 years old * traumatic or non-traumatic sci * admitted to inpatient rehabilitation within 6 weeks * t9 level of injury and above who are at greatest risk of morbid ngb * regionally located to allow follow-up * english or spanish speaking exclusion criteria: * history of genitourinary diagnoses (i.e. prostate hypertrophy, overactive bladder, cancer, etc.) * history of central nervous system disorder (i.e. prior sci, stroke, brain injury, parkinson's disease, ms, etc.) * history of peripheral neuropathy * pre-sci symptoms of peripheral neuropathy (numbness and/or tingling in feet, sharp/jabbing/burning pain in feet, sensitivity to touch, lack of coordination, muscle weakness, etc.) * pregnancy * known injury to the lumbosacral spinal cord or plexus, or pelvis with associated neuropathy * concern for tibial nerve pathway injury * absence of toe flexion or autonomic dysreflexia during electric stimulation test * potential for progressive sci including neurodegenerative sci, als, cancer myelopathy, multiple sclerosis, transverse myelitis

Keywords: electric stimulation sci spinal cord injury neurogenic bladder
point of care ultrasound (us) versus detailed radiology us for deep vein thrombosis (dvt)

Conditions: DEEP VEIN THROMBOSIS

Summary: we propose an observational study to assess the ability of intensivists to evaluate for deep vein thrombosis using 2 point compression ultrasonography.

deep vein thrombosis is a common problem in the intensive care unit and diagnosis is often delayed due to limited availability of a formal duplex ultrasound. physician performed 2 point compression ultrasonography has been shown to have reasonable accuracy when performed in the emergency department and outpatient setting, but has not been studied on patients in the intensive care unit. we propose an observational study to assess the ability of intensivists to evaluate for deep vein thrombosis using 2 point compression ultrasonography.

Eligibility criteria:
inclusion criteria: * male and female adults at least 18 years of age * duplex ultrasonography ordered by treating team * admission to the medical, cardiac, burn, or surgical intensive care units exclusion criteria: * patients less than 18 years of age * patients with a known current dvt * patients on whom the exam cannot be performed (above the knee amputation, severe cellulitis of groin or popliteal fossa, hip or knee fracture)

Keywords: venous thrombosis ultrasonography intensive care unit
physiotherapy in lumbar disc pathologies

Conditions: Lumbar Disc Disease; Lumbar Disc Herniation; Low Back Pain, Mechanical; Low Back Strain

Summary: the aim of this study is to compare the effectiveness of four physical therapy treatment approaches for lumbar region pathologies. eighty volunteers who have back pain will be included in the study. subjects will be randomly divided into four groups; group 1: soft tissue mobilisation techniques and stabilization exercises (n=20), group 2: kinesiotape and stabilization exercise (n=20), group 3: stabilization exercises (n=20), group 4: reflexology and stabilization exercises (n=20).

all patients will be measured with visual analog scale for pain level, goniometric measurement for range of motion, hamstring tension and sit and reach for flexibility, isokinetic evaluation for strength in 60degree/ sec, side plank position test for trunk stabilization. function will be measured with oswestry disability index. manual muscle testing for flexion, extension, lateral flexion of back, flexion, extension, abduction of hip, flexion, extension of knee and inversion, eversion of ankle will be assessed. group 1, 2 and 4 will be started to treatment twice a week for 4 weeks after first evaluation. group 3 will be had home exercise programme after first evaluation. groups will be assessed again at 4th and 8th weeks after treatment. multiway variant analysis will bee done within each group before the treatment and at follow-up. when differences observed, tukey test will be used to find out the group that caused the differences.

Eligibility criteria:
inclusion criteria: * the participants between the ages of 25 and 55 years, * having a minimum pain level (at activity) of 3 out of 10 on visual analog scale * having low back pain for at least 3 months with lumbar disc pathology (bulging or protrusion) diagnosed by clinical tests and magnetic resonance imaging. exclusion criteria: * sacroiliac and lumbar degenerative pathologies, * another pathology related to neurological deficits, * physiotherapy previously received for at least 12 months, * any surgery affecting the lumbar region.