Kornimate/medical-research-clean huggingface dataset:
stepped care in the treatment of trichotillomania

Conditions: Trichotillomania

Summary: trichotillomania (ttm), repetitive pulling out of one's own hair to the extent that noticeable hair loss occurs, is a distressing condition interfering substantially with functioning and quality of life. the longterm objective of this research is to determine whether psychological treatment of ttm could be disseminated more effectively by using a stepped care model in which less intensive interventions are tried first, with more intensive interventions used only if initial treatment proves insufficient. this project is a pilot study of the first two steps in a stepped care model of treatment. after baseline assessment, 50 participants with ttm will be randomly assigned to (a) immediate condition, in which they are offered 10-week self-help treatment via an interactive website (step 1) or (b) wait list/delayed start condition, a 10-week wait list prior to being offered step 1. in each condition, at the end of step 1, participants will be offered 8 weeks of in-person habit reversal training provided by psychology graduate students (step 2). ttm symptoms will be measured from baseline through a follow-up 3 months after the end of step 2, as will depression, anxiety, quality of life, functional impairment , treatment utilization, and treatment satisfaction. the specific aims of the study are: 1. to gather preliminary data on the efficacy of web-based self-help, compared to wait list control; 2. to characterize the acceptability of stepped care to patients with ttm by assessing the proportion of enrolled participants who proceed from step 1 to step 2 treatment; 3. to evaluate the convergent validity of four decision rules for concluding that a patient with ttm has benefited sufficiently from a treatment step: (a) no longer meeting ttm diagnostic criteria; (b) showing a 25% or greater reduction in total scores on self-report and clinician-rated ttm symptoms; (c) achieving complete abstinence from hair-pulling; and (d) clinically significant response on both self-report and clinician-rated ttm symptom measures 4. to evaluate the concurrent and predictive validity of criteria for sufficient benefit from a treatment step by relating them to treatment satisfaction, treatment utilization, and scores on a measure of functional impairment from ttm.


Eligibility criteria:
inclusion criteria: * 18 years or older * regular internet access * if taking medications for trichotillomania, on stable dose for at least 4 weeks * have trichotillomania (dsm iv criteria except that increasing and decreasing tension with pulling not required) exclusion criteria: * current suicidality * current major depression * current psychosis * current severe anxiety * current substance abuse * current psychotherapy focused on trichotillomania

Keywords: trichotillomania self-help web-based habit reversal behavior therapy
a study of two types of absorbable surgical sutures in the suturing of thyroid surgery incision

Conditions: Sutures

Summary: the primary objective of this study is to evaluate the efficacy and safety of two types of absorbable surgical sutures -- stratafix spiral pds knotless plus tissue control device and stratafix spiral monocryl plus knotless tissue control device (hereinafter referred to as spiral pds plus and spiral monocryl plus) used in thyroid surgery to suture surgical incision.

this study adopts a multicenter, prospective, randomized controlled design. the study population are subjects who undergo thyroid surgery. before the surgery, subjects are randomized in 1:1:1 ratio to the investigational group 1 (using spiral pds plus), investigational group 2 (using spiral monocryl plus) and control group. see the table below for the specific suture levels, materials and techniques of each group. a blinded central imaging evaluation will be performed on the healing condition of surgical incision on day 5-7 post-surgery. the subjects will be blinded to the type of suture used for wound closure.

Eligibility criteria:
inclusion criteria: 1. the subject is ≥18, and \<70 years old 2. planned open thyroid surgery, adopting an anterior cervical curved incision (kocher's incision); 3. subject who volunteers to participate in this study, follows the study requirements and follow-up visit and signs the written informed consent form voluntarily; 4. subject who agrees to not schedule any elective surgical operation except the study surgery before the study is completed; 5. the investigator considers the subject's expected postoperative survival time is not less than 3 months. exclusion criteria: 1. female subjects who are pregnant or lactation at screening; 2. preoperative clinical staging shows stage iv thyroid cancer, or cervical lymph nodes dissection is planned; 3. suspected or confirmed anaplastic thyroid cancer; 4. peripheral vascular disease affecting blood supply of the neck; 5. active infectious collagenosis (e.g. scleroderma), or any other disease that would interfere with wound healing; 6. fasting plasma glucose ≥7.7 mmol/l; 7. history of coagulation diseases; 8. current oral or intravenous antibiotic therapy for existing disease or infection; 9. history of immunosuppressant use (e.g. steroids) within the last 6 months; 10. chemotherapy or radiotherapy within the last 6 months, or planned chemotherapy or radiotherapy during the study; 11. personal or family history of keloid formation or hyperplasia; 12. current participation in any other drug (within 30 days or within 5 half-lives of the investigational drug) or device clinical study; 13. history of any thyroid surgery, except thyroid fine-needle aspiration biopsy; 14. planned use of skin adhesive at the incision site; 15. the subject is not suitable for participating in this study for any other reasons, as judged by the investigator.
magnetic resonance spectroscopy (mrs) validation study in individuals with nonalcoholic fatty liver disease (nafld)

Conditions: Liver Diseases

Summary: the purpose of this study is to see how effective the investigators' optimized magnetic resonance spectroscopy (mrs) sequence in quantifying hepatic triglyceride content (htgc) to enhance mrs as a diagnostic tool in non-alcohol fatty liver disease (nafld).

one way to gauge mrs as an effective diagnostic tool is by looking at the reproducibility of the liver fat measurements on subjects by calculating the coefficient of variation (cv). this study assesses the modified mrs sequence, using both breath holds and free breathing. the htgc levels are measured twice in the same individuals on two independent events separated by 10 minutes. subjects are then given a high fat, high carbohydrate meal of pizza hut pizza, pepsi, and oreo cookies. two hours after eating the meal, the subjects return to the scanner and repeat all mrs scans.

Eligibility criteria:
inclusion criteria: * obese exclusion criteria: * diabetes * pregnant

Keywords: obese mrs hepatic triglyceride content mr spectroscopy
single port vs standard tep for primary inguinal hernia repair

Conditions: Primary Unilateral Inguinal Hernia

Summary: this study is carried out to determine if laparoscopic inguinal tep repair of the hernia using a mesh carried out with only 1 port (hole) results in the reduction of post- operative pain and use of painkillers, shorter hospital stay and lesser complications than that carried out using conventional 3 ports.

100 patients undergoing laparoscopic tep ( total extraperitoneal repair) inguinal hernia repair under general anaesthesia will be randomized into 2 groups by the closed envelope method. in case of difficulty in single port tep inguinal hernia repair, the procedure will be converted to conventional 3 port repair for patient safety. 2 groups of participants: group a will undergo laparoscopic tep inguinal hernia repair with 3 ports (10 mm , and 2 ports of 5 mm ). group b will undergo laparoscopic tep inguinal hernia repair with a single port (12 to 15 mm transumbilical). patient will be informed at consenting that 3 wound plasters will be applied to their abdomen regardless of whether they are in the single port or 3- ports group so that they would not know which group they have been randomized to. the blind will only be lifted after pain score and area of pain has been recorded before discharge.

Eligibility criteria:
inclusion criteria: age: 21- 80 yrs * informed consent * diagnosis of hernia * asa i and ii * bmi\<25. exclusion criteria: bleeding disorders * age below 21 * strangulated hernia * bmi \> 30 * incarcerated and obstructed hernia * recurrent hernia * bilateral hernia * previous lscs * previous lower abdominal surgery

Keywords: inguinal hernia primary laparoscopic surgery single port surgery
multimodal approach of electrotherapy versus nerve flossing technique in patient with carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome

Summary: carpal tunnel syndrome (cts) is the most common and median nerve neuropathy at the wrist, caused by compression of the median nerve at the level of the carpal tunnel (ct) delimitated by the carpal bones and the transverse carpal ligament(tcl) which is the intermediate part of the flexor retinaculum (fr). the cts remains a challenge for health care providers due to its high prevalence and economic consequences, it is projected that in every 5 patients, 1 complains of symptoms of pain, numbness and a tingling sensation in the hands, cts is estimated to occur in 3.8% of the general population with an incidence rate of 276:100000 per year and happens more frequently in women than in men so a prevalence rate of 9.2% in women and 6% in men

the cts is a common clinical problem caused by the entrapment of the median nerve at the wrist, it is an important mononeuropathy that causes of hand pain, neurologic symptoms, and functional limitation of the hand, it is the most common nerve compression disorder of the upper extremity ,it accounting for 90% of all neuropathies, it is estimated that cts affects approximately is between 3.7% and 5.8% of the general population with a prevalence rate up to 9.2% in women and 6% in men , cts is 10 times more frequent in women than men , the peak age range of cts is between 40 to 60 years ,it is mostly seen in women ages between 30 to 50 years due to the housework they do, however, it occurs in all age groups

Eligibility criteria:
inclusion criteria: fifty one female patients have unilateral with mild to moderate cts in dominant hand diagnosed and reffered by physician. age will be ranged from 30-45years (atya et al.,2020) patients with mild to moderate cts will particiepate into the current study according to the classification of aaem exclusion criteria: patients with diabetes mellities ( type i or type ii), patients with hypertension patients with hypothyroidism patients with rheumatological disease patients with renal disease

Keywords: carpal tunnel syndrome
validation of stimulated ∆fgf19 for diagnosing bile acid diarrhoea

Conditions: Bile Acid Malabsorption

Summary: this study aims to validate a possible diagnostic test for bile acid diarrhoea prospectively compared to the sehcat scintigraphy. fasting participants are given a standard meal and 1,250 mg chenodeoxycholic acid. the investigators measure fasting fgf19, bile acids species including 7-alpha-cho and serial blood samples after the stimulation.


Eligibility criteria:
inclusion criteria: - consecutive patients referred for sehcat exclusion criteria: * treatment with sequestrants within one week before the sehcat. * treatment with any constipants/laxatives one day before the sehcat, with the exception of opioids, if the dosis has been stable in the prior 2 weeks. * pregnancy, screening by pregnancy test before inclusion. * breastfeeding women. * small bowel resection, including right sided hemicolectomy. * any ongoing treatment for inflammatory bowel disease with systemic steroids (i.e. budesonide or prednisone) or treatment in the prior 4 weeks. * allergies to constituents of xenbilox: (chenodeoxycholic acid, cornflour, magnesium stearate, highly dispersed silica, gelatine, sodium dodecylsulphate, titanium dioxide (e171), quinolone yellow (e104), erythrosine (e127) * chronic or acute cholecystitis. * liver cirrhosis, * obstructed bile flow causing jaundice or elevated p-bilirubin (\> 1,5 unl). * known disability in gall bladder contractility. * bile duct atresia. * frequent gallstone attacks (\>2/month).
lanreotide in polycystic kidney disease study

Conditions: Autosomal Dominant Polycystic Kidney Disease (ADPKD

Summary: lips study (lanreotide in polycystic kidney disease study) is a prospective randomized double blind placebo controlled study. the main objective is to prove that lanreotide, a somatostatin analog, is able to reduce the glomerular filtration rate decline over 3 years by at least 30%. cardiovascular outcomes, blood pressure, quality of life and safety are among the secondary outcomes. the study, which will include 180 adpkd patients, is scheduled to start in early 2014. an equal number of patients with chronic kidney disease stage 2 (90 patients with gfr 89 to 60 ml/mn/1.73 m2) and chronic kidney disease stage 3 (90 patients with gfr 59 to 30 ml/mn/1.73 m2) will be included. the primary endpoint (gfr decline) will be assessed by repeated measures, in the overall population as well as in the two gfr stratus.


Eligibility criteria:
inclusion criteria: * autosomal dominant polycystic kidney disease (clinical, familial, imaging grounds) * measured gfr : 30 to 89 ml/mn/1.73m2 * age \> 18 * affiliated with health insurance * written informed consent exclusion criteria: * iohexol /iodine allergy * diabetes mellitus * other associated nephropathy suspected * evolutive or recent malignant disease ( in the previous 5 years) * cholelithiasis * uncontrolled hypertension (bp\>160/100 mmhg) * cardiac failure of grade iii or iv according to the nyha (new york heart association) classification * liver failure * psychiatric illness * pregnancy, lactation, lack of contraception * use of somatostatin analogs during the last 6 months

Keywords: autosomal dominant polycystic kidney disease, glomerular filtration rate, somatostatin, lanreotide
benefits of amantadine in patients with coma state

Conditions: Coma; Prolonged; Amantadine

Summary: the study was a single center observational-prospective study and approved by local ethics committee. patients in coma state due to traumatic brain injury, cardiac arrest or ischemic stroke who are older than 18 years of age were included in the study. patients who received amantadine 200mg/day for fourteen days according to icu protocols decided by primary physician formed the amantadine group, and the rest of the subjects were included in the control group. all patients were evaluated for glasgow coma score, jfk coma recovery scale and disability rating scale once a week for three months.


Eligibility criteria:
inclusion criteria: * ≥18 years, ≤ 65 years * gcs score ≤ 8 * coma state due to ischemic stroke, brain hemorhage, anoxic brain damage exclusion criteria: * \ 65 years * patients admitted to the critical care without diagnosis of coma state * patients admitted to critical care with coma state that are not duo to ischemic stroke, brain hemorhage, anoxic brain damage * metastatic malignant neoplazm * congenital or acquired brain function problem (cerebral palsy, autism etc) * patients with amantadine allergy * progressive degenerative diseases (alzheimer, parkinson diseases etc)

Keywords: coma disability amantadine
correlation among standing-sitting sagittal spinal alignment, paravertebral muscle and postoperative clinical outcomes in patients with adult degenerative scoliosis

Conditions: Degenerative Scoliosis

Summary: this is a prospective single-center study. patients with adult degenerative scoliosis are prospectively enrolled and followed. all patients will take standard standing and sitting posteroanterior and lateral whole spine x-ray and lumbar mri examination before and after surgery. functional evaluation and radiographs were assessed preoperatively and postoperatively.this study will focus on the correlation among standing-sitting sagittal spinal alignment, paravertebral muscle and postoperative clinical outcomes in patients with adult degenerative scoliosis.

the sagittal alignment of the spine, or sagittal balance, describe the ideal and normal sagittal spinal curvature distribution. with the deepening of the research on spinal morphology, function and pathology, more and more researchers pay attention to the role of sagittal alignment in the diagnosis and treatment of spinal deformity diseases. some studies have shown that the restoration of patients with appropriate sagittal alignment can significantly improve their quality of life. besides, paravertebral muscle can also influence the retaining of sagittal alignment. however, how to define the ideal sagittal alignment is still controversial for different patients with adult degenerative scoliosis(ads) . it was proved that the differences in sagittal parameters of the standing and sitting positions positions were influenced by age, gender and pelvic incidence(pi). in addition, patients with high pi are more prone to sagittal decompensation after long segment fixation (fixation of three or more segments) .therefore, we speculate that the sagittal curvature of patients with large pi changes greatly from standing position to sitting position. so after long segment fixation, the spine in the state of standing position is more difficult to adapt to the changes of curvature and stress in sitting position, which is the possible reason that patients with high pi are more prone to sagittal decompensation. at present, how to design the proper corrective goals for patients according to both sagittal alignment and paravertebral muscle needs further research. thus, this study is aim to explore these three points about ads patients: the characteristics of the sagittal spinal alignment changes from standing to sitting ; the adaption of the spine curvature in the standing and sitting position after long segment fixation surgery and the relationship among standing-sitting sagittal spinal alignment, paravertebral muscle and postoperative clinical outcomes.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of adult degenerative scoliosis * cobb angle ≥10° exclusion criteria: * neuromuscular diseases * arthritis * tumor * a previous history of lumbar fusion surgery

Keywords: sitting standing sagittal alignment degenerative scoliosis paravertebral muscle
histological confirmation of clinical clearance of actinic keratoses following treatment with ingenol mebutate gel, 0.05%

Conditions: Actinic Keratosis

Summary: the main purpose of this trial is to demonstrate the predictive value of the clinical diagnosis of clearance of actinic keratoses after treatment with ingenol mebutate using histopathological examination as the standard.


Eligibility criteria:
inclusion criteria: * must be male or female and at least 18 years of age. * female patients must be on non-childbearing potential or if of childbearing potential then negative serum and urine pregnancy test and using effective contraception * ability to provide informed consent * subjects must have 5-9 clinically typical, visible and discrete ak lesions within a contiguous 25cm2 treatment area on the trunk and extremities except the back of the hand * ak should be confirmed by histopathology of one of the ak's prior to inclusion exclusion criteria: * location of the selected treatment area within 5cm of an incompletely healed wound or within 10cm of a suspected basal cell carcinoma or squamous cell carcinoma * undergone cosmetic or therapeutic procedures * use of acid-containing therapeutic products within 2cm of the selected treatment area in the 2 weeks prior to visit 1 * use of topical creams/lotions, artificial tanners or topical steroids within 2cm of the selected treatment areas in the 2 weeks prior to visit 1. * treatment with immunomodulators, or interferon/interferon inducers or systemic medications that suppress the immune system within 4 weeks of visit 1 * treatment with 5-fu, imiquimod, diclofenac, ingenol mebutate of photodynamic therapy within 2cm of the treatment area in the 8 weeks prior to visit 1 * use of systemic retinoids * those who are currently participating in any other interventional clinical trial * females who are pregnant or are breastfeeding * those known or suspected of not being able to comply with the requirements of the protocol or provide consent

Keywords: actinic keratosis histopathology reflectance confocal microscopy local skin reaction
single dose of etomidate and adrenal cortex

Conditions: Adrenocortical Deficiency; Hemodynamic Instability

Summary: we aim to evaluate the effects of single dose of etomidate or use of steroid prior to etomidate during emergency intubation on hemodynamics and adrenal cortex.


Eligibility criteria:
inclusion criteria: * patients between 25-65 years old with american society of anesthesiology scores iii or iv that have applied to emergency department and receives an indication for intubation by the intensive care unit physicians will be included to the study exclusion criteria: * patients using steroid prior to the intubation and/or patients with chronical inflammatory diseases will be excluded from the study.
genomic & proteomic analysis of docetaxel & capecitabine as primary chemo for stage ii-iii breast cancer

Conditions: Breast Cancer

Summary: the primary objective of this study is to determine the efficacy \& toxicity of combined docetaxel \& capecitabine as primary chemo for subjects w/ stage ii-iii breast cancer.

the primary objective of this study is to determine the efficacy \& toxicity of combined docetaxel \& capecitabine as primary chemotherapy for subjects with stage ii-iii breast cancer.subjects will be randomized into one of two groups: docetaxel followed by four cycles of docetaxel \& capecitabine vs. capecitabine followed by four cycles of docetaxel and capecitabine.

Eligibility criteria:
inclusion criteria: * histologically confirmed adenocarcinoma of the breast w/ stage ii-iii disease w/ a primary tumor \>/=2cm or clinically palpable axillary lymph nodes. * pre-treatment core or incisional bx w/ adequate tissue for histology \& genomic/proteomic analysis. * primary tumor must be bi-dimensionally measurable by physical exam or dx breast imaging. measurements must be obtained w/in 3 wks prior to study entry. * adequate organ fxn:agc\>1500; hb\>/=9.0;plts\>/=100k; crt\ /=50; total bili\</=uln; lfts\<2.0 uln * ecog performance status 0-1 * neg. pregnancy test exclusion criteria: * pts may not have had definitive primary surgery. * metastatic breast cancer * any prior chemo or hormonal therapy for breast cancer * prior history of malignancy w/in the previous 5 yrs. * no active unresolved infection * no major surgery w/in 2wks of start of study

Keywords: breast cancer stage ii breast cancer stage iii breast cancer