Kornimate/medical-research-clean huggingface dataset:
f-18-av-45 uptake, spot sign presence and cerebral amyloid angiopathy (caa) in primary intracranial hemorrhage (ich)

Conditions: Cerebral Amyloid Angiopathy

Summary: florbetapir f 18 is an experimental radioactive drug that may allow doctors to image changes in the brain using a pet (positron emission tomography) scanner. the purpose of this study is to evaluate the imaging characteristics of, florbetapir f 18 (also known as 18f-av-45) in patients who have previously undergone bleeding in their brains. florbetapir f 18 binds to amyloid-ß peptide (aß) that accumulates in the brains of patients with bleeding. these accumulations are called amyloid plaques and when extensive are labeled cerebral amyloid angiopathy (caa). florbetapir f 18 sticks to the amyloid plaques in the brain and emits a low level of gamma rays which can be detected by a pet camera. mri detected microbleeds have been identified as markers of clinically silent hemorrhage from bleeding-prone vessels. another imaging marker of vessel damage and risk of bleeding is the spot sign (ss). finally, certain genetic signatures (apoe genotype) have been shown to be associated with aß deposition in the brain or predispose patients to higher risks of bleeding. this research study will explore the interactions of these factors and understand the physiology of intracerebral bleeding.


Eligibility criteria:
inclusion criteria: * prior intracranial hemorrhage at least 3 months prior * patients \>18 years exclusion criteria: 1. modified rankin score \>3. 2. clinically significant medical comorbidities which in the opinion of the investigator might pose a potential safety risk to the subject. 3. women of childbearing potential who are not surgically sterile, not refraining from sexual activity or not using reliable methods of contraception. 4. have a history of relevant severe drug allergy or hypersensitivity 5. patients who withdraw consent. age and gender-matched microbleed patients previously demonstrating mri microbleeds without prior macrobleeds will be recruited from stroke clinic

Keywords: amyloid cerebral amyloid angiopathy hemorrhages cerebral spot sign
efficacy of aquatic physiotherapy in the treatment of upper limb lymphedema in women with breast cancer.

Conditions: Breast Cancer Lymphedema

Summary: this study aims to evaluate the effectiveness of aquatic therapeutic exercise by providing a set of exercises in the reduction and / or control the volume of secondary lymphedema treatment of breast cancer in patients who are in the maintenance phase of conventional treatment. it is an experimental, randomized, unifactorial, and intersubjective study. the intervention group will be treated by guided underwater exercises while the control group will receive the same set of exercises out-of-water. the research will be based on comparing the difference on the volume of lymphedema obtained by the exercises provided aquatic environment and out-of-water exercises. the study population will be obtained from rehabilitation service bellvitge hospital. the goal is to evaluate the volume of lymphedema and the quality of life related to the health of patients will be evaluated before starting the treatment, at the end of the 20 sessions, when the treatment reaches 3 months and when patient is discharged.

a randomized controlled experimental study has been carried out where two work groups were compared, experimental n: 43 that carried out an exercise regimen designed in the aquatic environment and control n: 47 that carried out the same regimen of exercises in a physiotherapy room. both groups did 20 treatment sessions of 45 minutes duration with a frequency of 2 or 3 days per week. lymphedema changes, quality of life and adherence to treatment were evaluated. the evaluations were 3 days prior to the start of the program, at the end of the 20 sessions, and at 3 months.

Eligibility criteria:
inclusion criteria: * female gender. * age between 18 and 75 years. * diagnosis of lymphedema in the upper limb secondary to breast cancer treatment. * present mild lymphedema or moderate (types i and ii respectively according to the volumetric classification of the types of edema according to severity). exclusion criteria: * primary lymphedema or secondary to other surgery. * bilateral lymphedema. * presence of hydrophobia. * severe cardiovascular and respiratory diseases. * urinary and fecal incontinence.
blood loss quantification during major abdominal surgery

Conditions: Blood Loss, Surgical; Blood Loss, Postoperative; Postoperative Complications

Summary: blood loss quantification during surgery remains unreliable and inaccurate. the purpose of the study is compare several methods of blood loss quantification in real surgical settings and to analyze the effect of blood loss on postoperative complications.


Eligibility criteria:
inclusion criteria: * patient scheduled for liver or pancreatic surgery * age of patient ≥ 18 years * signed informed consent provided exclusion criteria: * patient coagulation disorder (congenital or iatrogenic due to the chronic use of anticoagulants). * use of cell saver suctioning during operation * damage/clotting of blood samples
a multicenter prospective cohort study study of clag regimen in acute myeloid leukemia patients with first-induction failure

Conditions: AML

Summary: most of patients with acute myeloid leukemia achieved complete remission (cr) after primary induction chemotherapy, there were 20-30% patients without cr after first-induction. it was uncertain how to treat these patients. it was investigated in our study that these patients were re-induced with clag regimen. the cr ratio, overall survival (os) and relapsed-free survival (rfs) was statistically analysed in these patients.


Eligibility criteria:
inclusion criteria: * acute myeloid leukemia patients with first-induction failure exclusion criteria: * acute myeloid leukemia patients with serious infection and organ dysfunction.

Keywords: clag acute myeloid leukemia first-induction failure
tranexamic acid in traumatic brain injury

Conditions: Inflammatory Response

Summary: in this study, our aim is to investigate the role of tranexamic acid for modulating the inflammation in patients with traumatic brain injury (tbi).

this is double-blind trial, where group t will be received txa, where group c will be received saline placebo. in emergency room (er), trauma patients will be assessed and managed according to our local hospital protocol. after the initial resuscitation of patients. the selection was done according to the inclusion criteria. baseline investigations 1. c-reactive protein (crp), interleukin -6(il-6), c-reactive protein/albumin ratio (car), complete blood count (cbc) for neutrophil lymphocyte ratio (nlr), platelet lymphocyte ratio (plr). 2. prothrombin concentration (pc), prothrombin time (pt), activated partial thromboplastin time (aptt), and inr. group t, will be received txa (loading dose of 1gm of txa, followed by a 1gm of maintenance dose over 8 hours for 48 h). group c, will be received saline (loading dose of 1gm of saline 0.9%, followed by a 1gm of maintenance saline dose over 8 hours for 48 h) to monitor the post-interventional inflammatory response (cbc for nlr, plr), crp, il-6, c-reactive protein/albumin ratio (car), hemostasis (pc, pt, activated ptt, and international normalized ratio (inr)) and short-term outcome. conscious level will be assessed by glasgow come scale (gcs), delirium by richmond agitation-sedation scale (rass score) and hemodynamics will be continuously monitored. patients will be monitored and managed in intermediate or intensive care unit. adverse effects and complications will be recorded and managed.

Eligibility criteria:
inclusion criteria: * isolated traumatic brain injury patients (mild or moderate cases) * gcs \> 8 * non penetrating tbi in 8 hours onset * age ≥ 18 years exclusion criteria: * patient in cardiac arrest * patients with coagulopathies * renal failure patients * pregnancy * patient refusal to participate
the influence of oxytocin on socio-communicative sensitivity

Conditions: Oxytocin

Summary: oxytocin (ot) is a neuropeptide that acts as a neurotransmitter and neuromodulator in the brain. previous studies have shown that intranasal administration of ot improves social cognition and behavior (e.g. emotion recognition). in the current study, we want to gain more insight into the underlying mechanisms by which ot influences emotion recognition. more specifically, we will investigate whether intranasal administration of ot enhances the salience of social (compared to non-social) information and whether it increases the neural sensitivity for subtle socio-emotional cues, by recording scalp electroencephalography (eeg) during fast periodic visual stimulation (fpvs).

the present study is a double-blind, randomized, placebo-controlled, crossover clinical trial, in which (approximately 30) neurotypical male adults (18 to 30 years old) will participate. all participants will perform two sessions (ot and placebo), separated by two weeks. for the first session, the participants are randomly assigned to the placebo or the ot condition. syntocinon nasal spray will be used for intranasal administration. in each session, we will measure the neural salience/sensitivity for socio-emotional information, by recording eeg during fpvs. participants simply have to press a button when the fixation cross turns red, while watching rapidly alternating visual stimuli. starting 20 minutes after substance intake, four fpvs paradigms are administered in randomized order: 1. a frequency-tagging fpvs paradigm, to measure the salience of social versus non-social stimuli. 2. the oddball face detection paradigm, to assess the neural sensitivity to faces embedded in a series of objects. 3. the oddball identity discrimination task, to examine the ability to discriminate between faces with a different identity. 4. the oddball expression generalization task, to investigate the sensitivity for facial emotional expressions embedded within neutral faces with varying identities. after two fpvs paradigms, a four minutes resting state eeg measure will be performed. at the end of the session, emotion recognition will be measures with the palermo matching task (65 items). the primary aim is to investigate whether the performance on each of these paradigms/tasks differs between the ot and the placebo condition. furthermore, we want to explore whether the effect of ot is influenced by the participant's attachment style, social responsiveness, social phobia, or mood, which will be assessed via self-reported questionnaires.

Eligibility criteria:
inclusion criteria: * age between 18 and 30 years * male * right-handed * typically developing * normal or adjusted-to-normal vision (with glasses or lenses) exclusion criteria: * psychiatric disorder * neurological disorder (e.g. epilepsy, migraine) * color blindness * psychoactive medication

Keywords: oxytocin emotion recognition emotion processing social salience face processing electroencephalography (eeg)
graded ttce for post-embolization pavm monitoring

Conditions: Hereditary Hemorrhagic Telangiectasia (HHT)

Summary: current hht guidelines recommend ct scan to detect new or recurrent pavms after embolotherapy. recent studies using transthoracic contrast echocardiography (ttce) shunt grade for pavm screening suggest that graded ttce can accurately predict the size of pavms on chest ct and their amenability to embolization. this study's purpose is to evaluate whether ttce shunt grade can also accurately predict pavm size and amenability to treatment in patients who are post-embolization.

embolization is the standard of care for pulmonary arteriovenous malformations (pavms) in the hereditary hemorrhagic telangiectasia (hht) population. pavms are abnormal connections between the veins and arteries and result in right-to-left shunting of blood within the lungs. successful embolization results in pavm resolution and decreases the complications associated with right-to-left shunting. current guidelines recommend follow-up with interval chest ct scan to determine treatment success and detect new or recurrent pavms after embolization. this results in significant radiation exposure to the relatively young hht population. an alternative to chest ct is graded transthoracic contrast echocardiography (ttce), which measures the amount of right-to-left shunting within the lung and assigns a grade based on this amount. ttce has the advantage of being radiation free compared to chest ct. to date, graded ttce has only been studied as a screening tool for pavms. these studies have shown that graded ttce is highly sensitive in detecting pavms and is comparable to chest ct when screening for pavms. results indicate that ttce grade can accurately predict pavm size on chest ct and predict whether pavms are amenable to embolization. however, no studies have compared graded ttce and chest ct in patients who are post-embolization and it is therefore unknown whether graded ttce can be used in patients who have undergone pavm embolization. the current study seeks to correlate post-embolization ttce grade with chest ct findings to determine whether ttce can accurately predict pavm size and amenability to treatment in the post-embolization population.

Eligibility criteria:
inclusion criteria: * age range 18-89 years old * diagnosis of hereditary hemorrhagic telangiectasia by the curacao criteria * prior diagnosis of one or more pavms treated by embolotherapy * chest ct performed within the penn system for surveillance of pavms after \\ embolotherapy exclusion criteria: * known pavm recurrence on most recent chest ct with feeding artery size amenable to repeat embolotherapy * known history of intracardiac shunt * discovery of intracardiac shunt during transthoracic contrast echocardiography

Keywords: hereditary hemorrhagic telangiectasia (hht) pulmonary arteriovenous malformation (pavm) transthoracic contrast echocardiogram (ttce)
reducing health disparities in childhood obesity

Conditions: Obesity

Summary: in this study, we will address cost barriers to participating in summer programs and hypothesize this will lead to marked improvements in children's obesogenic behaviors and a reduction in excessive, unhealthy weight gain over summer.

for this study, we will rigorously test the impact of providing access to existing community-operated summer programs on weight status (i.e., bmi z-score) and obesogenic behaviors of 1st-3rd grade children from low-income households. using a pragmatic, type ii hybrid effectiveness-implementation randomized design, we will compare changes in weight status and obesogenic behaviors of children from low-income households randomized to one of two conditions: free summer programming or comparison/control.

Eligibility criteria:
inclusion criteria: 1st through 3rd grade students in the participating schools. exclusion criteria: the only exclusion criteria will be the diagnosis of an intellectual disability, such as: autism spectrum disorder down syndrome fragile x fetal alcohol and/or a physical disability, such as wheelchair use this decision was made because of the added resources required to evaluate these children, as well as the inability to sample enough of these children to adequately draw conclusions. no other exclusion criteria will be used.
effects of laryngeal tube ventilation on no flow time during out of hospital cardiac arrest

Conditions: Cardiac Arrest

Summary: international recommendations stress on the importance of no flow time reduction in cardiac arrest management. in fact, no flow time is an independent factor of morbidity and mortality. in france, cardiac arrests are treated by first responders (including emergency nurses) before the arrival of a mobile intensive care unit. those first responders use bag-valve-mask for ventilation and therefore practice conventional cpr (30 chest compression / 2 ventilation rhythm). laryngeal tube is a safe and efficient device in cardiac arrest ventilation. the purpose of our study is to compare the no flow time between two strategies of out of hospital cardiac arrest management by first responders: conventional cpr with bag-valve-mask ventilation vs. compression only cpr with laryngeal tube ventilation.

multicentric, prospective, controlled, randomized study with parallel groups in single blind. patients will be included in chronological periods to avoid selection biais (one month with the first medical device the next month with the other one). the determination of these periods will be centralized. the emergency vehicles will be supplied sufficiently with devices. this design has been chosen in order to answer to the emergency problem. patients will be included and ventilated by paramedical staff (first responders) before medical staff (mobile intensive care unit) intervention. complete detailed information will be given to the patient or to the family and consent asked. the comparison of no flow time between the two strategies in out of hospital cardiac arrest will be the following : a : ventilation by bag valve mask and interrupted chest compression b : ventilation by laryngeal tube and continuous chest compression

Eligibility criteria:
inclusion criteria: * preliminary treatment of cardiac arrest by fire fighters (basic life support) * more than 18 years * patient affiliated to the social security system or equivalent exclusion criteria: * certain death * patient deprived of freedom by judicial or administrative decision * patient under legal protection * pregnancy, parturient or breast feeding * facial trauma

Keywords: cardiac arrest no flow emergency nurse laryngeal tube
model driven diabetes care

Conditions: Diabetes Mellitus, Type 1

Summary: patients with diabetes mellitus type 1 using electronic self-help tools typically registers a large amount of data on their disease. the study intends to see if giving advanced feedback on these data can improve their blood glucose management.

all patients will be given access to a mobile phone with the diabetes diary known as the few touch application (fta) installed. they may use either their own compatible android handsets, or provided handsets. the study uses a delayed start design. participants are randomized into two groups, who get access to the module "diastat" after 4 and 12 weeks post-enrollment respectively. each group uses the fta with diastat for 8 weeks post-intervention (i.e. access to diastat). diastat is a module within fta that provides data-driven feedback to the patients using their own data. this module is based on the data recorded in a previous trial \[1\]. three submodules are part of diastat; periodicity detection and visualization, multiscale trend detection based on the c-sizer algorithm \[2\], and situation matching for insulin dosage \[3\]. 1. skrøvseth so et al, diabetes technol ther (2012) 2. skrøvseth so et al, plos one (2012) 3. skrøvseth so et al, accepted for advanced technologies and treatments for diabetes, paris, france, 2013.

Eligibility criteria:
inclusion criteria: * confirmed diagnosis with diabetes mellitus type 1 for at least one year. * age over 18 years * has basic familiarity with mobile phones, and uses mobile phone on a daily basis. exclusion criteria: * severe complications due to their diabetes. * unable to understand or conform to the guidelines when presented with the phone's software.
hrqol in patients with solid tumors treated with hadrontherapy

Conditions: Head and Neck Cancer; Skull Base--Cancer; Brain Cancer

Summary: the quality of life of patients treated with hadrontherapy is still limited. two cohorts are established, they will be receiving specific standardized questionnaires to be evalutaed in their results.

since 2011, cnao has been treating patients suffering from solid tumors with particle therapy (both protons and carbon ions). hadrontherapy improves outcome of radioresistant tumors which normally do not benefit from conventional radiotherapy. the treated population is highly heterogenous in term of tumor site, histotype, treatment fields and doses however its common anatomical origin justifies a unified approach in evaluating a qol in this setting. qol of patients suffering from these tumors have been poorly investigated and there are still few studies on patient reported outcomes (pros) and qol following hadrontherapy. in this context, therefore, there is a need to generate data by designing distinct cohort studies, conceived within a single protocol, that will gather quality of life data by means of standardized questionnaires of patients along their oncological history. thanks to this protocol design, the investigator will be facilitated, in the future, in adding new cohorts pending a study protocol amendment and ethical approval.

Eligibility criteria:
cohort a ("survivors"): inclusion criteria * patients with at least a follow up of 5 years with head and neck, skull base and brain tumors and no evidence of progressive disease. * the patient is able to give consent exclusion criteria: * re-irradiation. * second tumor. * known cases of any psychiatric and neurological diseases leading to disability (eg, manic disorder, schizophrenia etc..), which could impair compilation of questionnaires or affect quality of life. cohort b: inclusion criteria: * histological and/or radiological diagnosis of head and neck tumors * patients candidate for curative intent hadrontherapy * patients ≥ 18 years of age * the patient is able to give consent exclusion criteria: * re-irradiation. * second tumor * known cases of any psychiatric and neurological diseases leading to disability (eg, manic disorder, schizophrenia etc..), which could impair compilation of questionnaires or affect quality of life * presence of diffused metastasis

Keywords: cancer free survisorship hadrontherapy quality of life
reference ranges for placental perfusion using magnetic resonance imaging (mri)placentimage

Conditions: Placental Insufficiency

Summary: to evaluate the feasibility of functional mri method developed in an animal model and to construct normal reference ranges for in vivo placental perfusion using functional mri. this will be based on imaging studies in patients undergoing termination of pregnancy (top) at 16 to 32 weeks' for fetal reason in a tertiary referral center.

objective: to evaluate the feasibility of functional mri method developed in an animal model and to construct normal reference ranges for in vivo placental perfusion using functional mri. this will be based on imaging studies in patients undergoing termination of pregnancy (top) at 16 to 32 weeks' for fetal reason in a tertiary referral center. method: all patients undergoing top at 16 to 32 weeks will be offered to participate in this study. 120 patients will be included. 15 per group of weeks of gestation: 16+0-17+6 sa, 18+0-19+6 sa, 20+0-21+6 sa, 22+0-23+6 sa, 24+0-25+6 sa, 26+0-27+6 sa, 28+0-29+6 sa, 30+0-31+6 wg. mri will be performed in the same hospital, during hospital stay, within 45 minutes. two mri sequences will be used to measure placental perfusion: * dynamic sequences using gd contrast agent. * " spin tagging ", which do not need any contrast agent. perfusion will be modelled using compartmental analysis. reference ranges will be build up by statistical modelling. gadolinium assays will be performed on amniotic fluid and placental tissue following top. duration of inclusion: 24 months. duration of patient participation: 45 minutes. expected results: * feasibility in routine practice. * reference ranges for placental perfusion. * comparison between the two measurements methods. adverse outcome measure: nausea, vomiting, lack of comfort and other adverse outcome.

Eligibility criteria:
inclusion criteria: * women \> 18 years, * undergoing top for fetal reason, * informed signed consent. exclusion criteria: * placental adhesion anomaly, * growth restriction, * contrast agent allergy, * absent consent, * contraindication of mri or gadolinium, * renal insufficiency, * placental abnormality at pathological examination.

Keywords: placenta perfusion mri spin tagging gadolinium placental insufficiency urinary tract, sexual organs and pregnancy conditions