Kornimate/medical-research-clean huggingface dataset:
cgrp's cluster headache inducing abilities in cluster headache patients

Conditions: Cluster Headache

Summary: it has previously been shown that nitroglycerine induces cluster headache attacks in episodic cluster headache patients (ech patients) in bouts but not in remission phase. furthermore, plasma concentrations of calcitonin gene-related peptide (cgrp) have been shown to be significantly higher during, but not before and after, an attack. the attack appears around 20-40 min after nitroglycerine infusion with vasodilatation. during this latency period preceding the attack, no increase in cgrp plasma concentrations is seen. cgrp induces migraine attacks in 65% of migraine patients, and cgrp antagonists as well as monoclonal antibodies against cgrp are effective in migraine treatment. based on the above the investigators hypothesize the following: 1. provoking ech patients in bout with cgrp triggers cluster headache attacks 2. provoking ech patients in remission with cgrp does not trigger cluster headache attacks 3. provoking chronic cluster headache patients with cgrp triggers cluster headache attacks more often than in ech patients.


Eligibility criteria:
inclusion criteria: * fulfillment of ihs criteria for cluster headache either chronic or episodic * patients in bouts 1-32 attacks per week * patients in remission minimum of 1 month remission time * fertile women must use safe contraception exclusion criteria: * all other primary types of headache * headache 8 hours or less before study day begins * pregnant or lactating women * any history or clinical sigs of hyper/hypotension, heart disease, mental disorder, substance abuse, or other illness deemed relevant by the medical doctor assessing the patient
effects of scalp nerve block with ropivacaine on postoperative recovery quality

Conditions: Meningioma

Summary: patients undergoing elective meningeoma resection surgery will be randomly assigned to one of the following two groups. after anesthesia induction but before skull-pin insertion, one group will receive scalp nerve blocks with 0.5% ropivacaine, whereas the other group will receive scalp nerve blocks with 0.9% saline. the patients' postoperative recovery quality, which is evaluated by kps score, peri-operative inflammatory responses, and post-operative pain degree will be evaluated and compared between the two groups.

patients undergoing elective meningeoma resection surgery will be randomly assigned to one of the following two groups. after anesthesia induction but before skull-pin insertion, one group will receive scalp nerve blocks with 0.5% ropivacaine, whereas the other group will receive scalp nerve blocks with 0.9% saline. the patients' kps scores at 3d after surgery and at discharge, serum levels of tnf-α、il-6，il-1β at 24h after surgery, satisfaction score after recovery, and vas scores at 1, 2, 3 days post-surgery will be evaluated and compared between the two groups.

Eligibility criteria:
inclusion criteria: 1. 18-75 years old; 2. bmi 18-28 kg/m2; 3. asa physical status 1-2; 4. clinical diagnosis of primary meningeoma and will have elective meningeoma resection surgery; 5. with an estimated surgery time of less than 4h; 6. the incision will be conducted at the frontal, top or the temperal skull. exclusion criteria: 1. a history of previous brain surgery; 2. severe systemic disease (heart, lung, kidney, or immune system); 3. nerval or mental disorders; 4. a history of addiction to opioids; 5. allergic to ropivacaine; 6. infection at block site or severe systemic infection; 7. refuse to attend the trial.
apricot-3: antithrombotics in the prevention of reocclusion in coronary thrombolysis -3

Conditions: Myocardial Infarction

Summary: reocclusion of the infarct artery is observed in about 30% of patients within three months after successful thrombolysis for acute myocardial infarction (mi). reocclusion is associated with an increased risk of death, reinfarction and the need for revascularization. even in the absence of clinical reinfarction, reocclusion results in impaired left ventricular (lv) recovery, leaving patients at increased risk of developing heart failure in the long-term. prevention of reocclusion is therefore warranted. in previous trials, severity of the infarct related stenosis was the only independent predictor of reocclusion. with a lack of clinical predictors of reocclusion, many cardiologists therefore empirically favor routine revascularization after successful thrombolysis. the apricot-3 will be the first randomized trial in the current era of improved angioplasty techniques to study the question of whether a routine invasive strategy after successful thrombolysis can reduce the incidence of reocclusion and subsequently improve clinical outcome and lv-function. after successful thrombolysis, patients will be randomized to either a routine invasive strategy or an ischemia-guided strategy. the investigators expect to demonstrate a lower reocclusion rate at the 6-month follow-up angiography (primary endpoint) and fewer associated events (death, reinfarction, revascularization, admissions for heart failure) in the routine invasive arm. in search of non-invasive parameters predictive of reocclusion, laboratory analysis of several coagulation and inflammatory markers will be performed. finally, pooled analysis of all 3 apricot trials will focus on the identification of clinical predictors of reocclusion that can easily be obtained by history and physical examination.

randomized controlled study of elective percutaneous coronary intervention (pci) of an open culprit lesion after fibrinolysis for st-elevation myocardial infarction (stemi)

Eligibility criteria:
inclusion criteria: * timi-3 in infarct-related artery with a stentable lesion with 72 hours of thrombolysis for st-elevation myocardial infarction exclusion criteria: * use of oral anticoagulants. * known intolerance to aspirin or clopidogrel. * bypass graft as infarct-related artery. * previously dilated infarct related artery. * significant left main stenosis. * unidentifiable culprit stenosis.

Keywords: open infarct-related artery within 72 hours of thrombolysis
the effectiveness of 3 orthodontic fixed retention schemes on post-treatment stability and gingival recession

Conditions: Relapse; Orthodontic Retention

Summary: there is high possibility of relapse of the lower anterior teeth after orthodontic treatment. relapse is related with the initial orthodontic anomaly, pathology of surrounding tissues, patient's age and sex and compliance and the retention protocol applied. the options for the later are various. permanent fixed retainers are considered of the most common ones and vastly vary based of composition. there are fixed retainers distinguished for their composition (ss, β-niti, fiber-reinforced composite retainers) or for their shape and dimensions (round or rectangular shape and single-strand or multi-strand respectively), and/or for the teeth they are placed on (canine and canine or canine to canine). fixed retainers may require patient's cooperation , nevertheless debond failure rate varies between 0.1-53%. the aim of this prospective randomized clinical study is to compare failure incidents and retention effect on lower anterior teeth after orthodontic finish between three different types of fixed retainers. there will be 3 arms studied in this research: a) single strand 0.016x0.022'' β-ti canine to canine, b) 0.028'' ss canine to canine and c) 0.027'' multi-strand twistflex canine to canine. variables such as repeatability of failures, and undesired tooth movements will be measured. measurements will be repeated every 3 months after patient's recruitment in this study, for one year period (12 months in total). intraoral scans will be collected during baseline (fixed retainer insertion) and after 12 months.


Eligibility criteria:
inclusion criteria: * patients treated with fixed orthodontic appliances (roth 0.018'' slot at their final finishing stage) * patients with fixed orthodontic appliances at least between their lower first premolars * no lower anterior teeth crowding (total irregularity index score = 0) * patients with no need of removable retention appliances on their lower teeth exclusion criteria: * active caries on adjacent or lingual surfaces of lower anterior teeth * active periodontitis * supragingival calculus * gum bleeding during bonding of fixed retainer * gingival pocket depth greater than 3mm * syndromes or other anomalies of the craniofacial complex or other mental illness * missing or impacted teeth or other dental anomalies * congenital anomalies/syndromes * allergies regarding the alloys of fixed retainers * need for chemoprevention before data collection of periodontal indexes * diabetes * smoking * usage of antibiotics * pregnancy * participation in other clinical trials
specific or non-specific manipulation for patients with back pain

Conditions: Low Back Pain

Summary: we aim to evaluate the long-term effects of 10 sessions of spinal manipulative therapy applied in a vertebral region-specific or region nonspecific level immediately after treatment and 3 and 6 months after randomization.

to evaluate the long-term effects of 10 sessions of spinal manipulative therapy applied in a vertebral region-specific or region nonspecific level immediately after treatment and 3 and 6 months after randomization. 148 patients with chronic non-specific low back pain will be enrolled for this clinical trial. patients will undergo to a specific physical examination in order to determine the ideal lumbar spine level to be manipulated. the outcomes of interest are pain intensity, pain pressure threshold, global perceived effect and disability associated with back pain. after the first assessment patients will be randomly assigned to two groups that will receive 10 sessions of spinal manipulation over a period of four weeks, and may receive manipulation according to the findings on physical examination (specific manipulation) or may receive manipulation in the upper thoracic region, disregarding the physical examination findings (nonspecific manipulation).

Eligibility criteria:
inclusion criteria: - patients with low back pain duration from 3 to 24 months. exclusion criteria: * patients with a pain duration lower than 3 months and higher than 24 months. * patients with nerve root compromise or with serious spinal pathology, * pregnant patients, * previous back surgery * patients with any contra-indication to spinal manipulation.

Keywords: back pain spinal manipulation
multimedia education for frail patients

Conditions: Frailty

Summary: the goal of this clinical trial is to explore the impact of precision health care interventions on inpatients in acute medical institutions regarding their risk of falls, management, and prevention knowledge, as well as the incidence of falls among these patients. the main questions it aims to answer are: what is the effectiveness of precision health care interventions on inpatients' knowledge of fall risk in acute medical institutions? what is the effectiveness of precision health care interventions on inpatients' knowledge of fall management in acute medical institutions? what is the effectiveness of precision health care interventions on inpatients' knowledge of fall prevention in acute medical institutions?

frailty relates to the concept of physical deterioration associated with the aging process, which includes a weakening of the physiological and integrated physical strength of the body, its reserve and resistance to stressors, resulting in poor health, such as loss of physical and mental performance. frailty is an important health care topic in patients with geriatric syndromes. once the elderly enter the early stage of frailty, they are likely to fall repeatedly. studies have shown that frailty and premature aging are important predictors of falls in the elderly. therefore, professional medical staff should use frailty assessment indicators as early as possible to assess the possibility of frailty among the elderly in medical institutions or communities. at the same time, effective prevention strategies should be adopted to prevent reduce the incidence of falls due to frailty and improve the quality of life of patients and the elderly. therefore, assessment of possible falls and frailty risks is a priority in acute care settings.

Eligibility criteria:
inclusion criteria: 1. patients admitted to general acute wards and surgical patients 2. fall assessment score ≥ 3% of the high-risk group for falls exclusion criteria: 1. patients who were bedridden for a long time before admission 2. patients suffering from mental illness 3. the patient or primary caregiver cannot respond effectively

Keywords: fall frailty multimedia health education
effectiveness of an observational unit at st. olavs hospital

Conditions: Emergency Patients

Summary: the trial is designed to evaluate the effectiveness of a newly established observational unit at st. olavs hospital in terms of readmission rates, compared to the provision of care in normal/traditional units for defined diagnosis and medical problems.

observational units are thought to be more efficient than traditional ward units, but the evidence is scarce. the trial will in a randomized fashion evaluate the study hypothesis at an organizational level and not confined to specific diagnosis. the hypothesis to be tested is to confirm or reject the equal effectiveness of an observational unit compared to a traditional ward for organizing in-hospital care.there are established eligibility and exclusion criteria based on clinical experience. endpoint is length of stay and readmission within 30 days. in addition the study will give information on the use of diagnostic and treatment resources used and collect some basic demographic variables.

Eligibility criteria:
inclusion criteria: * emergency admitted patients only * all patients on the list (appendix 1) with a tentative length of stay \< 24 hours * predicted stay of less than 24 hours * willingness and able to sign a informed consent exclusion criteria: * emergency admitted patients with life threatening illnesses * patients with a tentative length of stay \> 24 hours based on the summary of medical and logistical considerations e.g. need of major - surgery, infections with prolonged infusions of antibiotics. * unwillingness to sign a informed consent * by discretion of the physician/surgeon * readmission of any reason in the study period (within 30 days)

Keywords: observational units length of stay (los) readmission
cardiomyopathy tissue bank in a cancer population

Conditions: Heart Disease

Summary: any time the words "you," "your," "i," or "me" appear, it is meant to apply to the potential participant. the goal of this laboratory research study is to collect and store blood and tissue from patients who have a diagnosis of heart disease and may be at a high risk for the development of heart failure. this blood may be used in the future to identify genes that may play a role in developing congestive heart failure (chf) from chemotherapy or other sources. this is an investigational study. all will be enrolled at md anderson.

you will have a one time blood draw of 2 teaspoons of blood for use in future research. this blood may be studied in the future to try to find possible genetic or biochemical markers that may be the cause of chf. your blood will be drawn either on an outpatient basis or during a routine visit to the hospital. if you already have a central line or an iv placed, the blood will be drawn at these sites to decrease the pain and discomfort of the blood draw. the information obtained in this study will not be put into your medical records.

Eligibility criteria:
inclusion criteria: * patients who are at high risk for developing cardiomyopathy or congestive heart failure. * patients two months of age and older. exclusion criteria: * those that are not willing to sign an informed consent.

Keywords: cardiomyopathy tissue bank heart disease heart failure congestive heart failure
impact of the oral microbiota on relapse in hnscc patients

Conditions: Head and Neck Cancer

Summary: to characterise the impact of microbiota in radiotherapy efficacy


Eligibility criteria:
inclusion criteria: * head and neck cancer exclusion criteria: -
impact of pre-procedure cognitive status on outcome at 3 months after transcatheter aortic valve implantation

Conditions: Aortic Stenosis

Summary: this study plans to investigate the relationship between cognitive status pre-procedure, and clinical outcomes at 3 months in patients undergoing transcatheter aortic valve implantation (tavi).

this study plans to investigate the relationship between cognitive status pre-procedure, as assessed using the montreal cognitive assessment (moca) administered on a tablet, and clinical outcomes at 3 months as assessed by the varc2 criteria, in patients undergoing transcatheter aortic valve implantation (tavi)

Eligibility criteria:
inclusion criteria: * aged 18 years or over * scheduled to undergo tavi * provide informed consent * able to understand french exclusion criteria: * subjects under legal guardianship or other legal protection * subjects with documented severe dementia * subjects with anticipated poor compliance * subjects unable to understand french sufficiently well to perform the moca test * pregnant women * subjects within the exclusion period of another study

Keywords: transcatheter aortic valve replacement aortic stenosis cognitive status
covid-19: immunological mechanisms in multisystem inflammatory syndrome in children

Conditions: Multisystem Inflammatory Syndrome in Children; COVID-19; SARS-CoV-2 Infection

Summary: this study seeks to explore immunological mechanisms in patients with multisystem inflammatory syndrome in children (mis-c) to improve the understanding of this pathogenesis of this disease. in a cohort of mis-c patients diagnosed during the wild type, alpha, delta and omicron waves, research samples will be analyzed for whole-blood rna expression, proteomics, inflammatory cytokines, cellular immune populations, autoantibodies, as well as host genetic markers.

background multisystem inflammatory syndrome in children (mis-c) is a rare severe complication to sars-cov-2 infection in children. thousands of children worldwide have been hospitalized with this new disease. yet, the immunological mechanisms are sparsely described. aim the project seeks to explore immunological mechanisms in patients with mis-c. method from a prospective nationwide cohort of patients with mis-c from denmark (may 2020-march 2022), research samples will be investigated for whole-blood rna expression, proteomics, inflammatory cytokines, metabolomics, cellular immune populations, autoantibodies, as well as host genetic markers allowing for detailed mapping this disease. samples from mis-c patients will be compared to patients with bacterial and viral disease, and other inflammatory diseases. time frame sample identification: february 1 2022 to april 1, 2022. sample analysis: april 1, 2022 to december 31, 2022 perspectives new molecular-based tools may lead to improved understanding of the pathogenesis of mis-c. this could form basis for development of novel diagnostic markers, identification of severe phenotype and therapeutic interventions.

Eligibility criteria:
inclusion criteria: * patients diagnosed with mis-c, according to the cdc criteria aged 0-17 years exclusion criteria: * patients from whom patient/parent/legal guardian signed consent is not received

Keywords: multisystem inflammatory syndrome in children
a study to assess adverse events and disease activity with cedirogant (abbv-157) in adult participants with moderate to severe psoriasis

Conditions: Psoriasis

Summary: psoriasis is a chronic disease characterized by marked inflammation and thickening of the skin that results in thick, scaly skin plaques. this study assessed how safe and effective cedirogant (abbv-157) was compared to placebo in adult participants with moderate to severe psoriasis. efficacy and safety-related measurements assessed disease activity in participants with plaque psoriasis. cedirogant (abbv-157) is an investigational drug being developed for the treatment of chronic plaque psoriasis. participants were put into 1 of 4 groups, called treatment arms and each group received a different treatment. there was a 1 in 4 chance that participants were assigned to placebo. participants received oral daily doses of cedirogant or placebo capsules for 16 weeks. there may have been a higher burden for participants in this study compared to usual standard of care. participants attended regular visits per routine clinical practice. the effect of the treatment was checked by medical assessments, checking for side effects, and questionnaires.


Eligibility criteria:
inclusion criteria: - participants with stable moderate to severe plaque psoriasis of at least 6 months duration and who are candidates for systemic therapy or phototherapy. exclusion criteria: * primary non-responders to previous anti-interleukin (il)-17 (e.g., secukinumab, ixekizumab, brodalumab), anti-il-23 (e.g., guselkumab, tildrakizumab, risankizumab), or anti-il-12/23 (e.g., ustekinumab) treatment for chronic plaque psoriasis. * diagnosis of erythrodermic psoriasis, generalized or localized pustular psoriasis, medication-induced or medication exacerbated psoriasis, or new onset guttate psoriasis or any other skin disease which may interfere with assessment of chronic plaque psoriasis.

Keywords: psoriasis plaque psoriasis cedirogant abbv-157
role of calcium and vitamin d in nutritional rickets and it's management

Conditions: Nutritional Rickets

Summary: rickets, a common nutritional disorder, is usually considered to be due to vitamin d deficiency. however, in the last few decades many studies have shown that in tropical countries, with abundance of sunshine, calcium deficiency may play a more important role in the causation of rickets. studies from adults in india have also shown that calcium intake of our population is much below the recommended allowance. the calcium deficiency gets compounded by the high level of phytates in the conventional vegetarian diet consumed by the majority of the population. there are few studies on children in india / other asian countries on assessment of dietary calcium intake. however, recent studies from many nations of the world have also shown a wide spread prevalence of vitamin d deficiency in adolescent and adult population. a study done at our own hospital has shown a high prevalence of vitamin d deficiency in lactating mothers and their infants. since both calcium and vitamin d deficiency are likely to be present in children, it is not clear what plays a more important role in the etiology of rickets in india or other asian countries. the present study is therefore planned with the following objectives: 1. to study the dietary calcium intake, sun exposure and serum vitamin d levels in children with and without rickets. 2. to compare the role of calcium carbonate, vitamin d and a combination of the two in the treatment of nutritional rickets.


Eligibility criteria:
inclusion criteria: * children aged 6 months to 5 years with rickets exclusion criteria: * non nutritional cause of rickets * taken vitamin d or calcium supplements in last 6 months * children presenting with convulsions

Keywords: nutritional rickets calcium vitamin d