Kornimate/medical-research-clean huggingface dataset:
effect of mets* on cognitive performance and physical activity (metabolic syndrome)

Conditions: Metabolic Syndrome

Summary: metabolic syndrome (mets) increases the risk of developing diabetes and cardiovascular disease risk factors that are linked with each other, which is a metabolic dysfunction, which contains a combination of multiple. it is known that mets plays a role in the development of many diseases such as cardiovascular diseases, stroke, cancer, alzheimer's. studies have revealed that neuroinflammation, oxidative stress, abnormal lipid metabolism and impaired vascularization, which play a role in the pathogenesis of mets, affect the structure of the brain and cognition. atherosclerosis of the carotid artery, increased brain atrophy and white matter damage are potential explanatory mechanisms that lead to an impact on cognitive skills in patients with mets. in addition, the existence of mets components such as obesity, diabetes, hypertension alone also negatively affects cognitive functions, and the level of cognitive influence also increases as the number of components an individual has increases. the literature reports that learning, executive functions, processing speed, attention/working memory and global cognitive functions are affected in individuals with mets, but no consensus has been reached on this issue. some studies say that mets causes a significant decrease in cognitive functions, while some studies indicate that this difference is not significant. the aim of our study is to proof the relationship between mets and cognitive functions with metabolic syndrome components. h1:there is a relationship between the mets and cognitive functions.

voluntary participants who have been diagnosed with mets and agreed to voluntary health subjects will be included in the study. signed voluntary consent will be obtained from participants. participants will be divided into two groups. there will be individuals diagnosed with mets in the intervention group and healthy individuals who do not have any problems in the control group.

Eligibility criteria:
inclusion criteria: * being between the ages of 18-50 * having been educated for at least 5 years and know how to read and write * having been diagnosed with mets by meeting 3 of the ncep-atp iii criteria (for participants in the mets group) * to have a biochemistry test performed within the last 6 months (for the healthy group) * not having any mets components (for the healthy group) exclusion criteria: * having any neurological, psychiatric and psychological diseases that may affect cognitive status * taking antipsychiatric medication * the presence of any visual-auditory intellectual disability * having undergone bariatric surgery

Keywords: cognitive function physical performance adults chronic disease
the purpose of this study is to investigate safety and tolerability of tropifexor.

Conditions: Liver Disease

Summary: the purpose of this study is to determine whether dosing tropifexor is safe and tolerable.

this was a randomized, subject and investigator blinded, multicenter, parallel-arm study to assess the safety and tolerability of tropifexor dosed in the evening as compared to dosing in the morning in subjects with non-alcoholic steatohepatitis (nash). subjects whose eligibility was confirmed were randomized with stratification by domicile status at day 1 of the treatment period into tropifexor (200 μg) am dose group (hereafter referred to as am dose group) or tropifexor (200 μg) pm dose group (hereafter referred to as pm dose group) in a 1:1 ratio. subjects in the am dose group took tropifexor in the morning and placebo in the evening while subjects in the pm dose group took placebo in the morning and tropifexor in the evening for 4 weeks in a blinded manner.

Eligibility criteria:
inclusion criteria: -presence of liver disease exclusion criteria: * use of other investigational drugs at the time of enrollment, or within 5 half-lives of enrollment, or within 30 days, whichever is longer; or longer if required by local regulations. * subjects taking the following medicines unless on a stable dose (within 25% of baseline dose) for at least 3 months before randomization: type 1 diabetes and uncontrolled type 2 diabetes defined as glycated hemoglobin (hbalc) ≥ 9.5% at screening -calculated estimated glomerular filtration rate (egfr) ≤ 60 ml/min/1.73m2 (using the modification of diet in renal disease (mdrd) formula) subjects with contraindications to magnetic resonance imaging (mri) imaging.

Keywords: tropifexor fxr agonist
en-mass retraction by kilbon versus cat appliances

Conditions: Maxillary Prognathism

Summary: en-mass retraction by lingual retractor versus clear alighner therapy

comparative effectiveness of lingual retractor versus clear aligner appliances in adult patients with maxillary dentoalveolar protrusion treated by upper first premolars extraction and enmass retraction of maxillary anterior teeth segment using palatal orthodontic miniscrews :a randomized clinical trial

Eligibility criteria:
inclusion criteria: * adult patients with maxillary dentoalveolar protrusion with mild crowding exclusion criteria: * - adult patients with maxillary dentoalveolar protrusion with moderate to severe crowding
intrapleural urokinase for retained hemothorax

Conditions: Retained Hemothorax

Summary: intrapleural thrombolytic treatment with urokinase for retained hemothorax is effective and safe. however, previous study was limited in prospective observation study without control group.

we will recruit 32 patients in this study. the patients with retained hemothorax will be randomly divided into the urokinase group and the placebo group. in the urokinase group, urokinase 100,000 iu in 100 ml nacl will be injected into the intrapleural space. we will record the daily drainage amount and evaluate the therapeutic effect by the chest x-ray. the therapeutic effect, safety, hospital stay, and medical cost between the two groups will be compared. this study will be done in four medical centers in northern taiwan.

Eligibility criteria:
inclusion criteria: 1. retained hemothorax: it is defined as chest x-ray revealing obvious blood clot in pleural cavity after tube thoracostomy drainage for 3 days. the chest tubes are in good location and have no obstruction. the physician thinks the blood clot is difficult to drain. 2. age: full 18 year-old exclusion criteria: 1. pregnancy 2. active bleeding 3. coagulopathy, e.g. congenital or acquired coagulation abnormality, platelet count less than 100,000 /μl, international normalized ratio (inr) more than 1.5, or partial thromboplastin time, ptt, more than 50 seconds after treatment. 4. cerebrovascular accident within 30 days 5. history of intracranial tumor or vascular abnormality 6. have received thoracic surgery 7. have received pleurodesis 8. wish to receive thoracoscopic surgery for hematoma evacuation directly 9. allergy to urokinase 10. sepsis 11. shock 12. people who are less than 18 years of age, prisoners, aborigines.

Keywords: non-surgical rate
efficacy of a web-based sexual violence risk reduction program for female college students

Conditions: Sexual Violence

Summary: this study evaluates the efficacy of a web-based program for female college freshmen ("realconsent") in reducing their risk of sexual violence victimization. half the participants will receive realconsent-f and half will receive an attention-placebo control ("stress and mood management").

sexual assault of college women is a serious and complex public health problem: one in five college women report being sexually assaulted. the purpose of this study is to conduct a randomized controlled trial study with 750 female college students from three universities to test the efficacy of realconsent, a sexual violence risk reduction program for college women, compared to an attention-placebo control. realconsent is a multi-media 3-hour program based on social cognitive theory and alcohol myopia theory. the primary outcome will be self-reported sexual violence victimization and the secondary outcomes will be alcohol and dating protective- and risk-related behaviors and resistance strategies. the investigators expect that women in the treatment group will report less sexual violence victimization than women in the control group. expected outcomes are demonstrated feasibility and efficacy of a technologically novel risk reduction program for female college students.

Eligibility criteria:
inclusion criteria: * female, aged 18-20 years, full-time freshmen, matriculated at georgia state university, emory university, or university of georgia, and single (i.e., not in a committed dating relationship). exclusion criteria: * other education levels, married, and/or graduate status
manual therapy effectiveness in comparison with electric nerve stimulation (tens) in patients with neck pain

Conditions: Neck Pain

Summary: this study investigated effectiveness of manual therapy (mt) with electric nerve stimulation (tens) to reduce pain intensity in patients with mechanical neck disorder (mnd). a randomized multi-centered controlled clinical trial was performed in 12 primary care physiotherapy units in madrid region.

the purpose of tis study is to evaluate the effectiveness of manual therapy (mt) with electric nerve stimulation (tens) to reduce pain intensity in patients with mechanical neck disorder (mnd). design: randomized multi-centered controlled clinical trial. location: 12 primary care physiotherapy units in madrid region. ninety patients were included with diagnoses of subacute or chronic mnd without neurological damage, 47 patients received mt and 43 tens. the primary outcome was pain intensity measured in millimeters using the visual analogue scale. also disability, quality of life, adverse effects and sociodemographic and prognosis variables were measured. three evaluations were performed (before, when the procedure finished and six months after). seventy one patients (79%) completed the follow-up measurement at six months. in more than half of the treated patients the procedure had a clinically relevant "short term" result after having ended the intervention, when either mt or tens was used. the success rate decreased to one third of the patients 6 months after the intervention. no differences can be found in the reduction of pain, in the decrease of disability nor in the quality of life between both therapies. both analyzed physiotherapy techniques produce a short term pain reduction that is clinically relevant.

Eligibility criteria:
inclusion criteria: * diagnoses of subacute or chronic mnd without neurological damage, according to the classification of the quebec task force on spinal disorders (spitzer 1987); * full physical and psychological capacity to follow the clinical trial's requirements; * consent to participate exclusion criteria: * signs of neurological damage according to the neurologic screening checklist (hoving et al. 2002), * pregnant women, * previous neck rachis surgery, * patients who received physical therapy or an alternative treatment of the neck or shoulder 6 months prior to the beginning of the study, * patients who intended to receive other treatments during the study * patients with important psychiatric disorders or other health problems that would contraindicate the techniques to be used (i.e. pacemaker). * patients with neck pain caused by an inflammatory, neurological or rheumatic disease, severe osteoporosis, fracture, luxation or vertebrobasilar insufficiency

Keywords: neck pain primary health care manual therapy tens
ocular parameters in patients with sleep apnea

Conditions: Sleep Apnea Syndrome, Obstructive; Drowsiness; Blinking; Concentration Ability Impaired; Pupil Diameter

Summary: the aim of this study is to assess the ocular parameters of drowsiness in patients with diagnosed obstructive sleep apnea syndrome through objective methods of ocular imaging and subjective evaluation methods (questionnaire)

this is a single-center prospective comparative observational study. one hundred patients with drowsiness that will be examined in the sleep clinic of alexandroupolis university hospital, aged between18-70 years old, with distance uncorrected visual acuity ≥ (duva): 5/10 will be recruited. they will be separated into two groups, one consisting of patients with diagnosed obstructive sleep apnea and one without this diagnosis, according to the epworth sleepiness scale - ess, which is a valid tool for quantifying daily sleepiness. a 10-minute video in a foreign language (not english or greek) with greek subtitles will be presented to them and a questionnaire will follow to assess the level of concentration during the video (the subtitles are crucial to understanding the video's plot). the video will be displayed in a 11.6" screen with resolution of 1920x1080 pixels, at 70 cm patient-to-screen distance. the patients' eyes will be recorded during the video with a raspberry pi camera module ir-cut v2 (5mp,1080p) with 2 ir led lights, connected to a raspberry pi 3 model v1.2, operating at the original resolution of 1080×1920, at 20 cm patient-to-camera distance and an algorithm will be developed to analyze the following parameters: 1. the complete and incomplete blinks defined by the "length of palpebral fissure-to-iris diameter" ratio, 3. length of palpebral fissure of both eyes.

Eligibility criteria:
inclusion criteria: * patients with obstructive sleep apnea and controls, aged 18-70 years old, with distance uncorrected visual acuity (duva) ≥ 5/10. exclusion criteria: * (duva) \<5/10, * intraocular pressure lowering medications * former corneal or fundus disease * neurological or psychiatric conditions * mental disability * difficulty reading

Keywords: reading time fixation saccadic movements eyelid margin distance
the role of pet/mri in the diagnosis and treatment of children and adolescents with inflammatory bowel diseases

Conditions: Inflammatory Bowel Diseases; Crohn Disease; Ulcerative Colitis

Summary: the purpose of this study is to test the utility of pet/mri in diagnosis and management of inflammatory bowel disease (ibd) in children and adolescents, hereby * to test if pet/mri scan is an accurate method to diagnose and differentiate crohn's disease and ulcerous colitis in children and adolescents suspected of ibd. * to evaluate whether pet/mri scan in children and adolescents with crohn's disease is an accurate method to diagnose relapses and to monitor the effect of biological treatment with monoclonal antibodies directed towards tumor necrosis factor-alpha.

crohn's disease and ulcerous colitis constitute the primary inflammatory bowel diseases. crohn's disease can affect any part of the digestive tract, from mouth to anus, and inflammation can be present in all layers of the intestinal wall. ulcerous colitis is primarily located in the inner layer of the colonic bowel wall. in the pediatric population, current diagnostic strategies involve blood tests, fecal sampling (calprotectin), magnetic resonans (mri) scan and both upper and lower endoscopies. in this population endoscopy requires general anesthesia and involves the risk of bowel wall perforation. a known method of identifying inflammation is by positron emission tomography (pet). in this procedure a radioactively labelled sugar molecule is injected into the blood stream via a venous catheter. the inflammatory cells take op relatively more of the sugar, compared to normal cells, and the cells are visible on the scan. until now the anatomic localization of the inflammation has been poor but recently is has become possible to combine the mri scan with pet resulting in excellent localization, with minimal radiation exposure (corresponding to 1 year background radiation in denmark). to make diagnosis and identification of inflammation flares during treatment safer for children and adolescents we aim to investigate whether pet/mri is accurate in diagnosing ibd in children and adolescents and in diagnosing flares in children with crohn's disease.

Eligibility criteria:
inclusion criteria: * suspected of having ibd * planned to undergo standard evaluation or * known crohn's disease about to start anti-tnf therapy due to steroid dependency or disease relapse. exclusion criteria: * active or prior diagnosis of inflammatory disease other than ibd * active or prior diagnosis of cancer * type 1 diabetes * not able to lie still for the mri scan.

Keywords: positron emission tomography magnetic resonance imaging
compete cohort study

Conditions: PFO - Patent Foramen Ovale; Migraine

Summary: migraine attacks are episodic disorder that affects approximately 12% of the population, and studies have shown that 41-48% of migraineurs have a combination of patent foramen ovale (pfo). clinical observational studies have been linking pfo occlusion with the effectiveness in improving migraine symptoms and reducing the frequency of attacks. however, several rcts have shown negative primary results, making it unclear whether pfo occlusion is effective in treating migraine. our study is a multi-center cohort study aiming to find the correlation between pfo closure and migraine attacks.


Eligibility criteria:
inclusion criteria: 1. age 18-65 ； 2. diagnosed migraine by ichd-3 3. history of migraine longer than 1 year, and symptoms severely disturbing daily life. 4. tcd/tte/tee diagnosed patent foramen ovale with right to left shunt 5. willing to participant and agree to follow-ups 6. received at least three different types of migraine preventive drugs, the responder rate of previous therapy did not receive 50%. exclusion criteria: 1. migraine caused by other reason 2. had tia/stroke history 3. with contraindication or hypersensitive to anti-platelet or anticoagulation drugs. 4. with contraindication to pfo occlusion
coronary arteriogenetic heparinized exercise

Conditions: Refractory Angina; Chronic Stable Angina

Summary: this study evaluates the addition of heparin to a 2-week cycle of physical rehabilitation in the treatment of refractory angina. half of the patients will undergo heparin-primed physical rehabilitation, while the other half will undergo only physical rehabilitation.

our approach is based on the combination of pharmacological stimuli (with heparin) on top of a 2-week cycle of physical rehabilitation. the rationale for this chemical-physical cocktail stems from the fact that increase in shear stress (achieved with exercise), or heparin (when used alone) have no significant effect on coronary arteriogenesis. nevertheless, when the two stimuli are coupled coronary arteriogenesis is consistently present, and clinically significant. the basic principle of heparin treatment is to potentiates angiogenic growth factors, which are over expressed by increased shear stress at the site of pre-existing collateral vessels as a result of exercise or pacing. although the precise mechanisms by which heparin potentiates arteriogenesis remain to be completely elucidated, heparin administration combined with exercise has great potential in treating patients with effort angina who are not indicated for conventional revascularization therapy.

Eligibility criteria:
inclusion criteria: * patients with documented coronary artery disease not amenable of future treatment and belonging to "no-option" category with symptoms consistent with angina pectoris exclusion criteria: * patients with unstable angina, recent myocardial infarction, uncontrolled hypertension, hemodynamically valvular heart disease, bronchial asthma, and neurologic and/or orthopedic illnesses that limit exercise capacity . * patients receiving vitamin k antagonist. * patients actively involved in programmes of cardiac rehabilitation or exercise training.

Keywords: no-option patients
cryo global registry

Conditions: Atrial Fibrillation

Summary: cryo global registry a prospective, global, multi-center, observational post-market registry

the cryo global registry is a prospective, global, multi-center, observational post-market registry (pmr). the purpose of this study is to evaluate and describe clinical performance and safety data in a broad patient population treated with a commercially available arctic front™ family of cardiac cryoablation catheters (hereafter referred to as "arctic front™ cardiac cryoablation catheter system"). the cryoballoon ablation(cba) procedure will be performed according to routine hospital practice. the study is expected to have a 24 month enrollment period. the follow up period is intended to align with standard practice and subjects will be followed for a minimum of 12 months post-procedure.

Eligibility criteria:
inclusion criteria: * subject is ≥ 18 years of age or minimum age as required by local regulations * planned procedure using commercially available arctic front™ cardiac cryoablation catheter * willing to comply with study requirements and give informed consent (defined as legally effective, documented confirmation of a subject's voluntary agreement to participate in this clinical study) or authorization per institution and geographical requirements exclusion criteria: * subject is enrolled in a concurrent study that has not been approved for concurrent enrollment by the global study manager * subject with exclusion criteria required by local law
performance evaluation of capsule endoscopy in the diagnosis of gluten sensitive enteropathy (ma-23)

Conditions: Celiac Disease

Summary: the purpose of this study is to determine how well capsule endoscopy identifies changes in the small bowel mucosa of celiac disease patients.

gluten-sensitive enteropathy (gse), also known as celiac disease, is characterized by abnormal small intestinal mucosa arising as a consequence of an inappropriate inflammatory response to ingested gluten in susceptible individuals. these changes cause a loss of absorptive capacity which in turn leads to variable degrees of malabsorption. a person suffering from celiac may have symptoms ranging from mild iron deficiency anemia to severe diarrhea and weight loss. characteristically, removal of gluten from the diet is followed by resolution of the mucosal changes and the symptoms. celiac disease is suspected on the basis of clinical signs and symptoms, and is generally confirmed by serological testing and small bowel biopsy. patients with suspected celiac disease undergo upper gi endoscopy with mucosal biopsy of the duodenum, in order to detect the characteristic histological changes. although the main role for endoscopy in gse is to obtain tissue for histological examination, a variety of endoscopic changes have been described in these patients,such as nodularity of the mucosa and 'scalloping' or loss of the duodenal mucosal folds. the given® diagnostic system can visually investigate the small bowel, producing high-quality images of the mucosa, which might be able to detect villous atrophy and thus could be used in the assessment of patients with gse. whereas upper gi endoscopy is invasive, often requires sedation and may be uncomfortable, capsule endoscopy is less invasive, convenient to use and does not require sedation. capsule endoscopy could become an important tool for the non-invasive assessment of small bowel mucosa in gse.

Eligibility criteria:
inclusion criteria: * patient age is 18 years or older * patient agrees to sign the informed consent form * patient has positive celiac serology or negative celiac serology + iga deficiency and suffers from one or more of the following symptoms and/or abdominal biochemical values: 1. chronic diarrhea 2. weight loss 3. abdominal cramps 4. history of spontaneous abortion 5. iron deficiency anemia 6. osteoporosis 7. infertility 8. hypoalbuminaemia 9. low cholesterol 10. low prothrombin activity exclusion criteria: * patient is known or is suspected to suffer from intestinal obstruction. * patient has a cardiac pacemaker or other electro-medical device. * patient suffers from severe swallowing disorder or zenker's diverticulum * patient has any condition, which precludes compliance with study and/or device instructions. * female patient is pregnant * patient suffers from life threatening conditions * patient is currently participating in another clinical study.

Keywords: celiac disease capsule endoscopy small bowel disease