Kornimate/medical-research-clean huggingface dataset:
assessing fitting guides in alcon multifocal contact lenses

Conditions: Presbyopia; Refractive Errors

Summary: the purpose of this study is to compare an alternative fitting guide to a current fitting guide for optimizing contact lens parameters and determining contact lens prescription.


Eligibility criteria:
inclusion criteria: * sign informed consent; * normal eyes; * current full-time soft contact lens wearer needing presbyopia correction; * willing to wear lenses for a minimum of five days per week, six hours per day, and attend all study visits; * other protocol-defined inclusion criteria may apply. exclusion criteria: * use of systemic or ocular medications for which contact lens wear could be contraindicated as determined by the investigator; * eye conditions (past or present) as specified in the protocol; * currently wearing alcon multifocal (mf) contact lenses; * only one eye with functional vision; * contact lens wear in one eye only; * use of mechanical eyelid therapy or eyelid scrubs within 14 days before visit 1 and not willing to discontinue during the study; * other protocol-defined exclusion criteria may apply.

Keywords: contact lenses presbyopia multifocal
surgical treatment of periimplantitis in patients with risk factors

Conditions: Peri-Implantitis; Type 2 Diabetes Mellitus; Smoking, Cigarette; Periodontal Diseases

Summary: this study evaluates clinical and radiographic parameters among riks factor groups in patients with periimplantitis. this study will also treat and evaluate the patients response before and after surgical treatment.

periimplantitis (pi) is an inflammatory process that results in tissue attachment bone loss around the implant. periodontal disease, smoke habit and type 2diabetes mellitus have been recognized as potential risk factor indicators that might lead to complications establishment and progression around dental implants. pi treatment predictability has been shown limited and influenced by factors not totally clarified. the aim of this study is to evaluate the reparative response after pi surgical treatment at clinical and radiographic levelsin risk factors patients: type 2 diabetes mellitus, smokers and chronic periodontal disease.

Eligibility criteria:
inclusion criteria: implants diagnosed with peri-implantitis with boné defects; probing depth ≥ 4mm; positive bleeding on probing and suppuration score; radiographic bone loss ≥ 3mm; generalized chronic periodontitis (armitage, 1999); heavy smokers (\> 10 cigarets per day); type 2 diabetes mellitus tipo 2 (ada, 2005) with hba1c between 6.5% and 7.5% exclusion criteria: complete edentulism; mucosal disease; alcohol abuse; systemic disease except type 2 diabetes mellitus, that might interfere in periimplantitis progression; medication intake: anticoagulants, antineoplasics, contraceptives, bisphosphonates and antidepressives; medication intake in the last 6 months: antibiotics; medication intake in the last 3 months: antiinflammatories; aggressive periodontitis and anaphylactic shock history; periodontal treatment in the last 6 months before the baseline; periodontal pockets \> 7mm; light smokers (\< 10 cigarets/day); implant mobility.

Keywords: peri-implantitis inflammation therapy
study of lactulose in children with chronic liver disease

Conditions: Minimal Hepatic Encephalopathy

Summary: pediatric patients with chronic liver disease may have minimal hepatic encephalopathy(mhe)which can cause changes in behavior,intelligence and neurological function.by utilizing cognitive and developmental testing we will determine if patients have mhe. if so, we will trial 3 months of blinded placebo or lactulose treatment followed by a washout period with no treatment. at this time patients are re-tested and then begin another three month period switching to the opposite treatment of first 3 months.final cognitive/developmental testing will determine if lactulose treatment has any effect on mhe.

in addition ,serum ammonia levels will be obtained at beginning of study,post-washout and at end of study to evaluate lactulose effect on serum ammonia.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of mhe as result of cognitive, developmental testing, pediatric pt. with cirrhosis as evidenced by imaging/biopsy exclusion criteria: * patients with neurological,psychiatric or unstable medical conditions which may contribute to impaired cognitive function. * patients with known hearing or vision difficulties. * those patients who do not speak english will be excluded.

Keywords: encephalopathy pediatric liver disease pediatric cirrhosis serum ammonia levels
survey of mobilisation and breathing exercises after thoracic and abdominal surgery

Conditions: Abdominal Cancer; Heart Diseases

Summary: background thoracic or abdominal surgeries are followed by a shorter or longer period of immobilization and after major surgery there is a higher risk of developing cardiorespiratory complications. to prevent these complications, the patient is encouraged to change position and exercise in bed, get out of bed as early and as much as possible after the operation and to breathe with or without aids. there is no general definition of early mobilization and may start within a few hours to a few days after surgery. there is currently a lack of knowledge nationally and internationally about when the mobilization starts and what it contains. many patients also receive breathing training in connection with the surgery. there is currently no consensus on which method is preferable for which groups of patients. there are similarities and differences in practice in the world regarding postoperative breathing training. there are studies that have mapped practice after primarily thoracic surgery but also abdominal surgery. however, there are no studies that have mapped when the prescribed breathing training starts after different types of operations. the purpose of the study is to map when mobilization and breathing training starts after abdominal and thoracic surgery and what is then performed method the study will be carried out as a quality follow-up with mapping of practice. patients ≥ 18 years of age who are undergoing a planned or acute open, keyhole or robot-assisted surgery, who are extubated and who breathe spontaneously will be included. exclusion criteria are completed plastic, trauma, orthopedic or transplant surgery. the material will be recruited from swedish university hospitals and county hospitals for 20 days of surgery (monday through thursday) for five consecutive weeks. clinical benefit the study will mean that clinical practice is presented which, with regard to mobilization, is the first study ever that will present when this takes place and what is done and, with regard to breathing training, the first that shows when this training is initiated.


Eligibility criteria:
inclusion criteria: * ≥ 18 years of age * undergoing a planned or acute open, laparoscopic or robot-assisted surgeon in the thorax or abdomen * who are extubated within 24 h of surgery * breathe spontaneously within 24 h of surgery exclusion criteria: * reconstructive-, trauma-, transplantation- or orthopedic surgery.

Keywords: immobilization abdominal surgery thoracic surgery breathing training
68ga-fapi pet/ct in patients with various fibrotic disease

Conditions: Fibrosis; Positron-Emission Tomography

Summary: to evaluate the potential value of 68ga-fapi-04 positron emission tomography/ computed tomography (pet/ct) for the diagnosis and prognosis in fibrotic disease

subjects with fibrotic disease underwent 68ga-fapi-04 pet/ct scanning. fibrosis lesion uptake was quantified by the maximum standard uptake value (suvmax). subjects also received the conventional clinical assessment for liver fibrosis, such as magnetic resonance imaging(mri) , biopsy and blood biochemical indexes (bbi) testing. the sensitivity, specificity, positive predictive value (ppv), negative predictive value (npv) and accuracy of 68ga-fapi-04 pet/ct, mri and bbi were calculated and compared to evaluate the diagnostic efficacy.

Eligibility criteria:
inclusion criteria: * adult patients (aged 18 years or order) * patients with suspected or new diagnosed fibrotic disease (supporting evidence may include , bbi, mri, ct and pathology report) * patients who had scheduled 68ga-fapi-04 pet/ct scan * patients who were able to provide informed consent (signed by participant, parent or legal representative) and assent according to the guidelines of the clinical research ethics committee exclusion criteria: * patients with pregnancy * the inability or unwillingness of the research participant, parent or legal representative to provide written informed consent
liver cancer disparities in american indian and alaska native persons

Conditions: Hepatocellular Carcinoma; Cirrhosis, Liver; Hepatitis B

Summary: we are performing a pilot and feasibility randomized controlled trial (rct) of hcc screening by us + afp every 6 months (n=100), the current standard-of-care, versus amri + afp every 6 months (n=100) for 12 months (i.e. at time 0, 6 and 12 months) among ai/an patients with cirrhosis or hbv.

we are performing a pilot and feasibility randomized controlled trial (rct) of hcc screening by us + afp every 6 months (n=100), the current standard-of-care, versus amri + afp every 6 months (n=100) for 12 months (i.e. at time 0, 6 and 12 months) among ai/an patients with cirrhosis or hbv. we will compare the amri vs. the us arm with respect to the following outcomes: 1. compliance/feasibility of conducting all three screening tests (0, 6 and 12 months) - primary outcome 2. proportion of screening tests conducted that employed the appropriate screening protocol and used appropriate documentation of findings with the li-rads system - primary outcome 3. proportion diagnosed with hcc and stage at diagnosis - secondary outcome

Eligibility criteria:
inclusion criteria: * cirrhosis, any etiology, or chronic hbv infection * high risk of hcc * age 18-75 * competent to provide informed consent exclusion criteria: * prior diagnosis of hcc * current suspicion of hcc * prior receipt of any organ transplantation * participation in another hcc screening trial * ctp score \>=10 * meld-na score \>20 * gfr\<30 * poor life expectancy (\<5 years) * contraindication to mri * inability to complete study visits * currently pregnant
frozen embryo donation study

Conditions: Infertility

Summary: the purpose of this study is to improve patient understanding of and interest in donating frozen embryos resulting from in vitro fertilization (ivf) to others undergoing infertility treatment.

the first phase of this study involves the mailing of a survey to current boston ivf patients who have embryos frozen in storage. a survey will be sent to these individuals to assess their knowledge and understanding of frozen embryos and if they would be interested in embryo donation. the second phase of research will randomize these patients into two groups: control and intervention. the control groups will receive their standard of treatment regarding frozen embryos, which consists of receiving a yearly storage bill. the intervention group will receive a letter from their physician of record and a follow up phone call from a research assistant offering the opportunity to schedule a consult with a licensed social worker at boston ivf. the consult is meant to serve as a chance to discuss the difficult decision around embryo disposition. the consult for these patient will be free of charge, covered with funds from our grant. additional enhanced support services and educational services provided by embryologists, nurses and physicians in the frozen embryo donation service will be offered. these enhanced services will also be free of charge to subjects. the third phase of the study includes the mailing of a letter to a random sample of patients with embryos frozen in storage at boston ivf. this letter will be an invitation to contact boston ivf to schedule a consult with a licensed social worker to discuss embryo disposition options. the consult for these patient will be free of charge, covered with funds from our grant.

Eligibility criteria:
inclusion criteria: * patient at boston ivf with embryos frozen in storage

Keywords: in vitro fertilization (ivf) embryo donation
study to evaluate the safety and efficacy ofjaktinib hydrochloride tablets in severe alopecia areata

Conditions: Alopecia Areata

Summary: this was an open-label, multi-center, randomized phase ⅱ study. patients with severe alopecia areata were randomized to receive 50mg bid, 150mg qd or 200 mg qd of oral jaktinib hydrochloride tablets.


Eligibility criteria:
inclusion criteria: * 18 years age or older ,male or female； * alopecia areata diagnosed clinically； * patients with alopecia accounting for 50% or more of the total scalp area and stable for at least 6 months or more； * patients can complete treatment for at least six months； * requirements for pregnant or lactating female and male and female of childbearing age；female patients must be satisfied：menopause (defined as no menstruation for at least one year);or have been surgically sterilized；or have fertility, but must satisfy：pregnancy tests conducted within 7 days before randomization must be negative；and agree to use appropriate contraceptive methods throughout the trial period, including at least one barrier method；and no breastfeeding；male patients must agree to use appropriate contraceptive measures throughout the trial, including at least one barrier method； * patients are voluntarily enrolled in the study and can be treated and visited according to the requirements of the protocol after signing the informed consent form； exclusion criteria: * alopecia caused by syphilitic alopecia, thyroid disease, trichotilomania, head moss, connective tissue disease, infection, zinc deficiency and iron deficiency; * patients with acute diffuse alopecia areata (adtafs) * patients with active tuberculosis * the following diseases were combined within 6 months before randomization:thyroid diseases ，liver diseases, malnutrition, heart diseases, nervous system diseases, gastrointestinal disorders, tumors and psychiatric diseases * hiv positive, active hepatitis b virus positive (hbsag or hbeag positive) and hcv-rna positive at screening； * other patients with abnormal history or clinical manifestations that may affect participants participation in the study or may confuse the results of the study； * within two weeks before randomization，patients who received glucocorticoid topical therapy, anthracene ointment, minoxidil, sadbe/dpcp contact immunotherapy, photochemotherapy or cryotherapy； * before randomization，oral or injected any medicines to treat hair loss (including the glucocorticoids was detected in injection, systemic corticosteroids, antihistamines, stephania drugs, glycyrrhizin, glycine, methionine compound tablet, compound glycyrrhizin glucoside) and other liquorice extract, ring spore element, anti tnf antibody, ifn - gamma, il - 2 antibodies, for alopecia areata therapy of traditional chinese medicine and other jak inhibitor) and washout period less than seven half-life of patients; * participants in a clinical trial of any drug or medical device within 4 weeks prior to randomization.
effectivity and safety of pfo closure vs medicine in alleviating migraine

Conditions: PFO - Patent Foramen Ovale; Migraine

Summary: effectivity and safety of pfo closure vs medicine in alleviating migraine （spring）: a multicenter, random, case control study


Eligibility criteria:
inclusion criteria: 1. presence of pfo with right-to-left shunt, confirmed by transthoracic. 2. echocardiography (tte) or transesophageal echocardiography (tee) with a bubble study. 3. bubble study positive confirmed by transcranial doppler. 4. subject is diagnosed of migraine. 5. subject signs an informed consent form and is willing to participate in follow-up visits exclusion criteria: 1. subject is diagnosed of headache with clear etiology. 2. subject had cerebral hemorrhage, bleeding events in other organs within 3 months or was in high risk of bleeding. 3. brain ct/mr showed ischemic lesions. 4. subject is diagnosed of hepatic insufficiency: alt or ast\>3×uln at the screening visit. 5. subject is diagnosed of moderate to severe renal insufficiency: egfr\<30ml/min/1.73m2 at the screening visit. 6. subject has uncontrolled arrhythmia with clinical significance within 90 days. 7. subject is diagnosed of unstable angina, severe coronary atherosclerosis or myocardial infarction within 90 days. 8. subject is diagnosed of pulmonary artery embolism, peripheral artery embolism or deep vein thrombosis. 9. subject cannot follow the study procedure due to other acute or chronic diseases. 10. subject is pregnant or lactating. 11. subject is under other rct. 12. subject has a life expectancy \<1 year. 13. subject cannot follow the study procedure due to other reasons in the opinion of the investigators.
investigation of the use of a probiotic supplement in people with long covid

Conditions: Long COVID

Summary: this study is a double-blinded randomised trial to assess the efficacy of a probiotic supplement in alleviating symptoms in people with long covid.

240 participants with long covid will be randomly assigned to either a probiotic or placebo group in a 1:1 ratio for twelve weeks. participants will track symptoms using an app for three weeks before the study, and for the last three weeks of the treatment. participants will answer online questionnaires about their symptoms at 0, 4, 8, and 12 weeks. a subgroup of 60 participants will attend the laboratory for blood tests, cognitive function tests and gut microbiome analysis at 0 and 12 weeks. this group will also wear activity trackers for two weeks before the study, and for the final two weeks of the study.

Eligibility criteria:
inclusion criteria: long covid defined as national institute for health and care excellence (nice) criteria for long covid (persistent symptoms at least 12 weeks after a confirmed or suspected covid-19 infection). - exclusion criteria: significant co-morbidities - no pre-existing diagnosis of hypertension, diabetes, cerebrovascular, cardiovascular or peripheral vascular disease, coagulopathy or haematological disorder or current or recent cancer. -
complaints and presumptive diagnosis in a danish emergency department

Conditions: Symptoms on Admission; Presumptive Diagnosis on Admission; Final Diagnosis

Summary: acute patients in denmark are often admitted to emergency departments by their general practitioner with a presumptive diagnosis. the aim of this study is to evaluate the diagnostic value of the pre-admission presumptive diagnosis and to assess if the presumptive diagnosis could be replaced by a number of symptom-based groups.


Eligibility criteria:
inclusion criteria: * all acute patients admitted to emergency department exclusion criteria: -
acupuncture for vulvodynia: a pre-pilot study

Conditions: Vulvodynia; Vulvar Vestibulitis; Dyspareunia; Pain

Summary: vulvodynia is a women's pain condition. women have pain in their vulva, the area in their genitals between the vagina and labia (lips of the vagina). they also have pain when they have sexual intercourse or insert anything in the vagina. sometimes they have so much pain, that they cannot have sex. this research is being done for two reasons. the first reason is to test a set of special needles called double-blinded acupuncture needles to give acupuncture treatments (one is a real needle and the other is a fake needle). the second reason is to develop a protocol (checklist) that will be used in this and future studies, and to identify and resolve any procedural problems. the protocol will be first tested by the principal investigator who is also an acupuncturist. the investigator will perform acupuncture using the protocol, if necessary change the protocol, and then teach a second acupuncturist using the modified protocol how to use the double-blinded acupuncture needles. the real needle called the penetrating needle penetrates the skin. the fake needle called the non-penetrating placebo touch needle does not penetrate the skin but it touches the skin so it feels like a needle is being inserted. it has a blunt tip. participants can't see which needle they are getting acupuncture with because the needles are housed in a double-blinded needle device which has two tubes (an inner and an outer) that neither the acupuncturists nor the participants can see through. if a fake acupuncture needle can be used in acupuncture research like a sugar pill is used for drug studies to see how well the real medicine works, the investigators can see how effective acupuncture is. the investigators will be testing these needles to treat participants with vulvodynia.


Eligibility criteria:
inclusion criteria: * women previously diagnosed with generalized vulvodynia * women previously diagnosed with localized vestibulodynia, exclusion criteria: * pregnancy * menopause * interstitial cystitis * irritable bowel syndrome * untreated vaginitis * cervicitis * pelvic inflammatory disease * any other pelvic pathology causing pain * concomitant physical therapy * concomitant biofeedback * concomitant massage * additional acupuncture
stress ventricular function in evaluating patients with pulmonary hypertension

Conditions: Dyspnea

Summary: this study investigated clinical parameters, laboratory data, imaging studies to evaluate patients with suspected pulmonary hypertension.

left and right ventricular ejection fraction (lv/rv ef) at rest and immediately after exercise treadmill test (ett) were measured by nuclear medicine study in consecutively symptomatic patients with suspected pulmonary hypertension, along with other clinical variables were correlated with right heart catheterization parameters.

Eligibility criteria:
inclusion criteria: * patients suspicious for pulmonary hypertension. exclusion criteria: * pregnant, lactating, cad history
flow diverter stent for endovascular treatment of unruptured saccular wide-necked intracranial aneurysms

Conditions: Intracranial Aneurysm

Summary: unruptured saccular intracranial aneurysms larger than 7 mm can be treated with endovascular occlusion using detachable coils, with or without expendable stent assistance. a new endovascular technique has recently been developed, using flow diverter stents without associated coils. clinical results already published are encouraging but have to be confirmed. furthermore, these medical devices are expensive in comparison to the coiling strategy. the purpose of this study is to compare the clinical efficacy, safety, and cost-effectiveness of endovascular coiling and endovascular flow diversion for unrupted saccular intracranial aneurysms.

main outcome measure: percentage of patients with an aneurysm with complete occlusion, defined as the absence of visible blood flow to the consideration of angiography performed 12 months post-endovascular intervention.

Eligibility criteria:
inclusion criteria: * patient's age ≥ 18 years old * unruptured saccular intracranial aneurysm diagnosed by angiography or ct angiography or mr angiography, located in the intra-dural area, with a neck diameter between 4 and 10 mm, with a sac diameter between 7 mm and 20 mm, with a ratio "dome/nek" greater than 1, and with a diameter of the parent artery between 2 and 5 mm. * no prior treatment of the aneurysm * agreement for participating in the study and informed consent signed by the patient * patient affiliated to a social security scheme exclusion criteria: * patient's age \< 18 years old * adult patient protected by law * contraindications to the endovascular procedure * contraindications to antiplatelet or anticoagulant treatment * prior treatment of the aneurysm * presence of an arteriovenous malformation * extradural location of the aneurysm * fusiform aneurysm * active bacterial infection (clinical signs) * intracranial hemorrhage from aneurysm in the previous month * pregnant or breastfeeding woman

Keywords: endovascular procedure; flow diverter stent