Kornimate/medical-research-clean huggingface dataset:
rightwhey - responders in gut health markers using fermented whey

Conditions: Health, Subjective; Healthy; Microbial Colonization

Summary: this 8-week intervention will investigate the effect of daily consumption of a fermented whey concentrate on the short-chain fatty acid profile of faeces in healthy individuals. this study will help us understand if consumption of fermented foods rich in lactic acid have a beneficial effect on gut health.

the 8-week dietary supplementation trial will investigate the action of exogenous lactic acid consumption on the activity (using short-chain fatty acid) and composition of the gut microbiota. participants will be stratified according to their baseline faecal butyrate levels. therefore volunteers will be asked to provide two faecal samples one week apart. based on the average absolute level of butyrate in the faecal samples, volunteers will be stratified into either low, moderate or high baseline butyrate levels (detailed in table 1 below). the levels for faecal butyrate for each group are set based on a meta-analysis of 9 human studies of healthy volunteers carried out at the rowett institute (n=116; labouyer et al, 2016, unpublished). thresholds were derived from the boundaries of tertiles. therefore, the moderate butyrate producers represent the middle 33% (see table). each stratification arm will have a minimum of 17 study volunteers bringing the total to n=51. this has been set to ensure the completion of at least 45 volunteers. to optimise equal gender distribution amongst all study arms a minimum of 5 females and 5 males will be recruited for each arm. stratification butyrate range low ≤13 mm moderate butyrate 13 - 20mm high butyrate ≥20mm primary and secondary outcomes will be analysed between the low and high butyrate producing groups as well as the overall group effect on everyone.

Eligibility criteria:
inclusion criteria: * i. men and women aged 18-68 years; bmi ranging from 18-35 kg/m2; measured at the screening visit exclusion criteria: * i. smokers * ii. subjects with: diagnosis of diabetes, pregnant, hypertension, renal, hepatic, haematological disease, coronary heart disease or any gastrointestinal disorder * ii. unsuitable veins for blood sampling; * iii. inability to speak, read and understand english. * iv. use of antibiotics within the last 3 months will automatically exclude volunteers. * v. vegans. fermented whey concentrate, (fwc), is derived from milk (animal product) which excludes potential participants adhering to a vegan diet. * vi. allergy to any of the following: cow milk, lactose, casein, whey, sucralose, acesulfame k, citric acid, potassium benzoate, fruit flavourings.

Keywords: fermented whey microbiota gut health butyrate
the effect of platelet rich plasma on non-scarring alopecia

Conditions: Androgenetic Alopecia; Alopecia

Summary: the purpose of this study is to evaluate the clinical efficacy of platelet rich plasma (prp) injections for non-scaring alopecia in women. a randomized, placebo-controlled clinical trial will be performed where patients with non-scarring alopecia will either receive injections of their own prp or injections of normal saline (placebo). patients in the treatment group (group a) will have a small amount of their own blood drawn and have their prp injected into their scalp four times. the injections will be given at weeks zero, four, eight, and twenty four. the placebo group (group b) will be given the same schedule but will receive sham injections only and will not have any blood drawn. both groups will have clinical data collected at all visits, including a screening visit before enrollment and a final assessment visit at week 40, for a total of 6 study visits per patient. data collection will include representative photographs of the scalp and measurements of hair thickness. the results from the two groups will then be compared. in summary, all study participants will have a screening visit before enrollment, four study visits for sub-dermal scalp injections, and one final assessment visit at week 40.


Eligibility criteria:
inclusion criteria: 1. must understand and voluntarily sign an informed consent form 2. must be female between the ages of 18 and 65 years at the time of consent 3. must be able to adhere to the study visit schedule and other protocol requirements 4. documented platelet count above 150,000 platelets per microliter within 6 months prior to enrollment exclusion criteria: 1. previous or current use in the last 1 year of finasteride, minoxidil topical or oral, or spironolactone 2. a diagnosis of non-androgenic alopecia (i.e: another diagnosis for the alopecia ) 3. no baseline ferritin, thyroid-stimulating hormone, platelet count, and a negative urine pregnancy test in any pre-menopausal female in past 12 months. 4. active skin disease (psoriasis or severe seborrheic dermatitis) of the scalp 5. scalp infection 6. severe active blood infection 7. cuts or abrasions on the scalp 8. history of surgical hair restoration 9. current or recent malignancy 10. history of systemic chemotherapy or radiation 11. history of thyroid dysfunction 12. history of autoimmune disorder (specifically graves disease, hashimoto thyroiditis, or systemic lupus erythematosus) 13. tendency to develop keloids 14. nonsteroidal anti-inflammatory or vitamin e discontinued in the last 7-14 days 15. platelet dysfunction syndrome 16. thrombocytopenia less than 150,000 17. diagnosis of hypofibrinogenemia 18. anticipated pregnancy or trying to become pregnant in the next 2 years
cognitive-behavioral therapy for weight-related bullying (online treatment)

Conditions: Bullying; Weight, Body; Trauma, Psychological

Summary: this study will perform a clinical trial with adolescents to pilot a new cognitive-behavioral treatment (cbt) for weight-related bullying testing (1) feasibility, (2) acceptability, and (3) initial efficacy. the treatment will be conducted via audio/video telehealth.

youth with obesity are more likely to be bullied than healthy-weight peers and weight-related bullying is the most common form of bullying. treating bullying during childhood could reduce immediate and long-term health consequences, but there are no established individual-level treatments for weight-related bullying despite recommendations that they could improve children's health. this study will develop and test a new treatment for adolescents (11-17 years old) who have experienced bullying due to weight. the treatment will address traumatic stress and potentially co-occurring or developing problems with unhealthy weight-control behaviors, disordered eating, and weight. the treatment will be conducted via audio/video telehealth to increase accessibility and is therefore available to anyone in the united states who meets eligibility criteria.

Eligibility criteria:
inclusion criteria: to be included, adolescents must: 1. be in the age range ≥11 years old and ≤17 years old; 2. report experiencing weight-related bullying 3. report current distress about weight-related bullying 4. be otherwise-healthy youth (i.e., no uncontrolled or serious medical conditions); 5. read, comprehend, and write english at a sufficient level to complete study-related materials; 6. located in the united states and available for participation in the study for 3 months. exclusion criteria: prospective participants will be excluded if the adolescent: 1. has a medical or psychiatric condition that would require hospitalization or intensive care (e.g., severe anorexia, neurological disorder, psychotic disorders, suicidality); 2. has uncontrolled medical condition(s) (e.g., uncontrolled diabetes or hypertension); 3. is pregnant or breastfeeding; 4. is taking medication(s) or participating in treatment(s) that could influence weight or appetite; 5. is engaged in concurrent treatments that focus on trauma-related stress; 6. began taking hormonal contraceptives less than 3 months prior; 7. has a developmental or cognitive disorder (e.g., autism spectrum disorder); 8. has avoidant/restrictive food intake disorder; or 9. is participating in another clinical research study.

Keywords: adolescent child cognitive behavioral therapy eating disorder obesity
coping compliance and adjustment in adolescents with cystic fibrosis

Conditions: Cystic Fibrosis

Summary: in this research, we will use established surveys to look at the relationship between various styles of coping with a disease, religious coping styles, treatment compliance, locus of control, broad measures of mental health and adjustment, and basic health data (e.g., pfts, recent hospitalizations or antibiotics within the past year, lung microbiology, cftr mutations, and co-morbid conditions such as diabetes, depression, and liver disease). while the research is correlational, it should suggest relationships (both positive and negative) between various coping styles and desired outcomes (compliance and well-being).

overview: we anticipate that the data we collect will help us better understand some of the factors associated with improved coping, treatment compliance, and emotional adjustment, which, in turn, may suggest possible interventions to improve compliance, emotional adjustment, and general physical health. specific hypotheses include the following: 1. subjects who score high on measures of positive coping will have greater levels of treatment compliance and psychological well-being. 2. subjects who score high on measures of negative coping will have lower levels of treatment compliance and psychological well-being. 3. subjects who score high on measures of positive religious coping will have greater levels of treatment compliance and psychological well being. 4. subjects who score high on measures of negative religious coping will have lower levels of treatment compliance and psychological well-being. 5. subjects who score high on measures of internal locus of control will have higher levels of treatment compliance and psychological well-being compared to subjects who score low on measures of internal locus of control. 6. subjects who score high on measures of treatment compliance will have higher levels of physical health. 7. we do not anticipate a positive correlation between positive coping mechanisms and general physical health; however, subjects who score high on measures of negative coping may have lower levels of general physical health (e.g., lower pfts, increased rates and lengths of hospitalizations) probably due to third variables (e.g., if someone uses denial as a coping mechanism, it may lead to poor treatment compliance, which may lead to declines in physical health). 8. anecdotal evidence suggests that parental education may be positively correlated with treatment compliance, but this has not been evaluated. likewise, anecdotal evidence suggest that marital status may be correlated with treatment compliance (probably because of third variables, e.g., if, as much research suggests, divorce is related to lower ses and fewer social supports, these factors may in turn interfere with treatment compliance). two questions on the demographic sheet will allow us to explore whether or not this may be worth exploring further.

Eligibility criteria:
inclusion criteria: * cystic fibrosis age 13-19 yrs exclusion criteria: * acutely ill

Keywords: cystic fibrosis adolescents coping compliance adjustment
prognostic determinants in patients with diabetic foot ulcer.

Conditions: Diabetic Foot Ulcer

Summary: the worse prognosis observed in patients with diabetic foot ulcer (dfu) has not been fully understood. poor prognosis may be related to other conditions (inflammation, infectious disease, cancers) further to cardiovascular disease. the aim of the study is to conduct the first prospective, observational and multi-centre cohort of patients with dfu in france, in order to evaluate the 5-years mortality rate, its causes and relevant prognostic determinants.

diabetic foot ulcer (dfu) is one of the major complications frequently observed in patients with diabetes. dfu is the leading cause of non-traumatic lower-limb amputation (lla), and it is associated with cognitive decline, worsening quality of life and substantial economic impact on french healthcare system. dfu is also associated with excess risk of premature death with significant decrease in life expectancy despite major improvement in medical care during last decades. the hypothesis of the study is that this worse prognosis seen in dfu patients may not be fully explained by a high cardiovascular risk, but mainly linked to different causes, including inflammatory, infectious and malignant conditions. in addition, to conduct the first prospective, observational and multi-centre cohort of patients with dfu in france to evaluate the 5-years mortality rate, its causes and relevant prognostic determinants, the investigators will also assess all changes in health-related quality of life (hrqol), and the economic impact related to dfu (cost of illness study) for the french healthcare system, using snds claims databases. a 3-year inclusion period will start during 2020, and each participant will be followed for 5 years or until death.

Eligibility criteria:
inclusion criteria: adults with diabetes and dfu, defined as a foot skin ulceration or open lla wound, measuring at least 5 mm of diameter, located below the malleolus, and induced by diabetic complications. in the case of an amputation before inclusion, the amputation stump will be considered as the main wound and not the wound that led to the amputation. exclusion criteria: * acute or chronic lower-limb ischemia without open skin wound, * foot infection without open skin wound, * intercurrent disease prohibiting participation in an observational study, * pregnancy or breastfeeding * curatorship or guardianship * prisoners -- patient currently participating to more than one other clinical study (interventional or observational, 2 study maximum including pdf) or currently participating to another study interfering with standard care of diabetic foot

Keywords: diabetes mellitus lower-limb amputation wound health-related quality of life cost-of-illness
get fit for function

Conditions: Thoracic; Frailty

Summary: the purpose of this study will be to implement and evaluate a prehab program for pre-frail and frail adults who need to undergo thoracic surgery. the study team hypothesizes using an implementation framework will increase the reach, effectiveness, adoption, and implementation of the prehab program.

approximately 70% of thoracic surgery patients are pre-frail or frail, characterized by reduced strength, endurance, and physiologic function. frailty is associated with poor perioperative outcomes, including increased complications, length of stay, post-discharge institutionalization, healthcare costs, and mortality. as a result, surgical and geriatric clinical societies now recommend including a frailty assessment in older adult pre-operative surgical evaluations. to mitigate the risks associated with frailty, prehabilitation (prehab) has been included as a component of the american college of surgeons "strong for surgery" quality initiative. evidence-based practices to optimize preoperative health have been shown to improve physical conditioning and return to autonomy, as well as, reduce length of stay, postoperative complications, and healthcare costs. older patients who need surgery view prehab favorably, particularly if it is home-based, recommended by a medical professional, and free. the primary objective will be to conduct a feasibility evaluation using the reach, effectiveness, adoption, implementation, and maintenance (re-aim) framework. the secondary objectives will be to measure functional status and clinical outcomes longitudinally in patients undergoing prehab. participants will receive the prehab program from 2-12 weeks prior to undergoing elective inpatient thoracic surgery. participants will complete surveys at 2-3 weeks, 2 months, 3-4 months, and 6 months after surgery.

Eligibility criteria:
inclusion criteria: * age ≥ 18, of any racial or ethnic origin * will be undergoing elective thoracic surgery lung resection using thoracic approach (thoracotomy, video-assisted thoracoscopic surgery (vats), robotic-assisted thoracic surgery (rats) * able to complete baseline evaluations at time of enrollment exclusion criteria: * unable to give informed consent * unable to read/speak english * age \<17
defects of keratinocytes function in dermatologic patients

Conditions: Hidradenitis Suppurativa

Summary: notch signaling in the skin exerts a pivotal role in the regulation of normal keratinocytes turnover by mediating the balance between proliferation, differentiation, apoptosis and autophagic flux progression. two skin diseases are characterized by the presence of gene variants that cause an impairment in notch signaling: hidradenitis suppurativa(hs) and dowling-degos disease(ddd). to date, both hs and ddd are orphan diseases still lacking of specific treatments. this project aims at improving the current knowledge on the pathogenesis of hs and ddd, by deepening the understandings on the role played by keratinocytes in these pathologies and also by determining why mutations found in the same pathway cause different diseases. this study aimed to obtain in vitro models, derived directly from patients (from hair follicles) and from keratinocytes (hacat) cell cultures, for the study of these skin pathologies and also for the testing of novel innovative therapies such as photobiomodulation therapy.


Eligibility criteria:
inclusion criteria: * diagnosis of hs exclusion criteria: * no informed consent

Keywords: hidradenitis suppurativa notch signaling
exercise in children attention deficit hyperactivity disorder

Conditions: ADHD; Exercise

Summary: attention deficit hyperactivity disorder (adhd) is a heterogeneous neurodevelopmental disorder characterized by carelessness, hyperactivity and impulsivity, in which genetic, social and physical factors play an important role. few studies have revealed the physical activity levels and importance of children with adhd, but there is no consensus on the components of the physical activity program such as intensity, frequency, and severity. the aim of the present study is to investigate the effect of combined exercise training on motor proficiency, physical fitness and cognitive status in children with adhd.

the aim of present study is to investigate the effect of combined exercise training on motor proficiency, physical fitness and cognitive status in children with adhd. children will be randomly divided into 3 groups, for 8 weeks the first group will undergo a combined exercise training under the supervision of a physiotherapist, while the second group will receive a home exercise program. children included in the third group will form the control group. the following assessments will be applied at the beginning and end of treatment. 1. revised conners parent rating scale short turkish form 2. powers and challenges survey 3. edinburgh hand preference survey 4. two-minute walking test 5. ten meter walking test 6. munich fitness test 7. bruininks-oseretsky motor proficiency test-2 8. muscle strength evaluation 9. dynamic occupational therapy cognitive assessment 10. open-ended questions

Eligibility criteria:
inclusion criteria: * having been diagnosed with adhd according to dsm-v (the diagnostic and statistical manual of mental disorders-v) diagnostic criteria, * being between the ages of 7-12, * right hand being dominant according to edinburgh hand preference questionnaire, * after the purpose of the study and the procedures to be explained, both the child and his family agree to participate in the study, * an appropriate drug treatment program has been organized by the psychiatrist, * the absence of a contraindicated condition to exercise in physical and medical examination. exclusion criteria: * a major psychiatric and / or neurodevelopmental problem accompanying, * a history of head injury or chronic neurological disease, * having additional medical diseases that require medication, * any changes made in the psychiatric drug treatment by the attending physician for the last 1 month, * have participated in a regular exercise program or sporting activity for the past 6 months.

Keywords: adhd exercise motor proficiency
evaluating different modalities for pleural adhesiolysis at assuit university hospital

Conditions: Pleural Effusion

Summary: interventional randomized clinical trial will be done at assuit university hospital ( chest department and caridothoracic surgery department ),and all patients presented with complex septate pleural effusion in whom the symptoms excepted to be relieved by pleural fluid drainage will be included in our study within the two next years.

the goal in the management of pleural effusion is to provide symptomatic relief by removing fluid from the pleural space and to allow the treatment of the underlying disease. despite the improvement in the management options of pleural effusion; intrapleural adhesions remain a significant problem in many patients with pleural disease. the presence of adhesions carry a poor prognostic factor in patients with exudative pleural effusions that it may render the drainage of pleural fluid difficulty inspite of tube being patent and correctly positioned. two options are currently available to deal with the problem of pleural adhesions, the first is chemical and the second is mechanical adhesiolysis . chemical adhesiolysis means lysis of the adhesive bands medically by instillation intrapleural chemical agents e.g. streptokinase, urokinase, tissue plasminogen activator, streptodornase, deoxyribonuclease (human recombinant \[hr\]dnaase), single-chain urokinase plasminogen activator and the uncommonly used mesna (2-mercaptoethane sulfonate na) . mechanical adhesiolysis means breaking up the adhesive bands and removing it by pulling and dissecting via medical thoracoscope, minimally invasive video assisted thoracoscopy (vats) or more invasive thoracotomy.

Eligibility criteria:
inclusion criteria: * patients with symptomatic pleural effusion in whom the symptoms excepted to be relieved by pleural fluid drainage. * presence of intrapleural adhesions as documented sonographically. * difficult thoracentesis. * failure of satisfactory pleural fluid drainage 24 hours following intercostal tube (ict) placement provided that the tube was properly positioned and not obstructed. * written consent, free and informed. exclusion criteria: patients have contraindications for any of our procedures will be excluded. * contraindications for streptokinase instillation i.e. (previous allergic reaction, bronchopleural fistula, trauma or surgery within 48 hrs, history of hemorrhagic stroke, coagulation defects and previous streptokinase thrombolysis). * patients who are unfit for general anaesthesia.
vibratory anesthesia in trigger finger injections

Conditions: Trigger Finger; Pain; Anesthesia, Local

Summary: this study aims to compare the effectiveness of the use of no topical anesthesia, topical coolant, and the use of vibration in the reduction of pain during trigger finger injections. this will be done by randomizing patients who are diagnosed with trigger finger, warrant and choose to continue with a steroid injection into each of the respective anesthetic (or lack thereof) methods described. after conducting this and gathering data on the subjects pain felt, we will compare the analgesia from each of the anesthetic methods.


Eligibility criteria:
inclusion criteria: * healthy adult * diagnosed with trigger finger * warrants a trigger finger injection exclusion criteria: * subjects with known decreased light touch sensation in the territory of the trigger finger injection. * not diagnosed with trigger finger or does not warrant a trigger finger injection per the typical treatment algorithm adopted by the attending physician.