Kornimate/medical-research-clean huggingface dataset:
management of stoma in patients younger than 3 months old

Conditions: Stoma Colostomy; Stoma Ileostomy; Neonatal Disease

Summary: indications for jejunostomy, ileostomy or colostomy vary in the neonatal population. the most common etiologies are congenital anomalies, such as anorectal malformations, intestinal atresia or hirschsprung's disease, but also acquired conditions, such as enterocolitis or intestinal perforation. the aim of these stomas is to divert stool in the event of intestinal obstruction or risk of fecal contamination. depending on the indication and the type of stoma used, the post-operative follow-up, such as resumption of intestinal transit and feeding, secondary closure of the stoma or not, and the duration and cost of hospitalization differ. the aim of this study is to compare these differences in order to extract an optimal management strategy, in the light of what is reported in the international scientific literature.

the investigators gathered the data of patients born between january 2009 and december 2023, who had an ostomy made during the first three months of their life. the investigators then analyzed the patients outcomes ( postoperative complications, length of stay, cost of hospitalization) depending on the etiology of their primary disease.

Eligibility criteria:
inclusion criteria: * patients who had a stoma during the first 3 months of life, from january 2009 to december 2023 exclusion criteria: * patients who had a stoma after the first 3 months of life, from january 2009 to december 2023 * patients without a stoma

Keywords: ostomy neonate outcomes costs
kinesiophobia in chronic neck pain

Conditions: Neck Pain; Kinesiophobia

Summary: in this study, the effect of kinesiophobia on pain, disability, and quality of life in individuals with chronic neck pain will be evaluated. neck pain is a common musculoskeletal disorder that can become chronic in some individuals. kinesiophobia may lead to a reduction in physical activity due to fear of movement and re-injury, thereby increasing pain and disability. in this cross-sectional study, 57 participants will be assessed using the visual analog scale (vas), tampa scale for kinesiophobia (tsk), neck disability index (ndi), and the sf-36 quality of life scale. participants will be selected from individuals aged 18-59 who have experienced neck pain for at least 3 months, and those with a history of neurological disorders, spinal surgery, or pain treatment in the last 3 months will be excluded. this research aims to determine the effects of kinesiophobia on chronic neck pain, thereby contributing to the development of more effective treatment strategies. written informed consent will be obtained from all participants.


Eligibility criteria:
inclusion criteria: * adults aged 18 to 59 * patients of both genders experiencing neck pain for at least 3 months exclusion criteria: * patients with neurological deficits * patients with any neurological disorder * patients with a history of spinal fractures, spinal tumors, or spinal infections * patients with a history of spinal surgery * patients with any congenital spinal anomaly * patients with vestibular disorders * patients taking antidepressant and antihypertensive medications * patients unwilling to participate in the study * patients who have received any pain treatment in the last 3 months * patients who have engaged in any strenuous physical activity within the 24 hours prior to the assessment

Keywords: chronic pain kinesiophobia disability quality of life
rate of blood pressure control among hypertensive patients with hemodialysis in sohag university hospital

Conditions: Hemodialysis; Hypertension

Summary: the goal of this cross-sectional study is to detect hypertensive patients with hemodialysis in sohag university hospital and controlled patients and noncontrolled patients. the main questions it aims to answer are: 1. what is the pattern of blood pressure control among patients receiving hemodialysis? 2. what are factors associated with successful blood pressure control? 3. what is the level of patient knowledge and awareness regarding blood pressure management? 4. what are the challenges and barriers faced by patients in achieving optimal blood pressure control? participants blood pressure calculated by taking the average of three consecutive days measurement.

1. survey type: cross-sectional study. 2. target population: patients undergoing hemodialysis. 3. sample size: the target sample size are all hypertensive patients in sohag university hospital dialysis unit 4. survey method: person to person interview in dialysis units will be used for data collection. blood pressure calculated by taking the average of three consecutive days * 1st day (dialysis day): - blood pressure will be measured (pre dialysis, inter dialysis, post dialysis). * 2nd day (inter dialytic day): - blood pressure will be measured two times (am, pm). * 3rd day (dialysis day): - blood pressure will be measured (pre dialysis, inter dialysis, post dialysis).

Eligibility criteria:
inclusion criteria: - participants must be * 18 years or older. * currently receiving hemodialysis. * hypertensive patients. exclusion criteria: * patients under 18 years old. * patients stopped hemodialysis. * patients with esrd not receiving hemodialysis.

Keywords: hypertension hemodialysis
brazil nut consumed on the metabolic profile, oxidative stress and nutritive microcirculatory patterns

Conditions: Obesity

Summary: the purpose this research is to check if brazil nuts consumed improvement the metabolic profile, state redox and endothelial function in obese adolescents.

the purpose this research is to check if brazil nuts consumed improvement the metabolic profile (lipid profile, glucose, insulin), state redox (about glutathione peroxidase, isoprostane and ldl-ox) and endothelial function (by videocapillaroscopy) in obese adolescents (12-18 years).

Eligibility criteria:
inclusion criteria: pubertal girls obese (bmi \> 30 kg/m) - exclusion criteria: consumption of nuts loss weight before the research chronic disease (hypertension) -

Keywords: obese brazil nuts oxidative stress microcirculatory metabolic profile
development of an aid to melanoma detection using artificial intelligence algorithms based on images from the vectra 3d system.

Conditions: Naevi

Summary: the background to this research is that frequent medical screening of the general population for melanoma is not feasible. the real challenge of this project is to develop an automatic process for detecting any potential melanoma. to this end, the project aims to design an algorithm to build a novel diagnostic aid that makes use of the similarity and disparity of pigmented lesions in the same patient. to achieve this, we need to obtain and structure a large database of images grouping all pigmented lesions per patient according to their similarities as perceived by dermatologists.


Eligibility criteria:
inclusion criteria: * male or female aged 18 and over * patient with more than 15 nevi (moles) of various phototypes (i to iii) * patient who has received information about the study and has not expressed any opposition * patient who is a beneficiary or entitled person under a social security scheme exclusion criteria: * patients with phototype v * patients with chronic inflammatory skin diseases * claustrophobic patients * patients who are bedridden or handicapped * patients who are excluded from another research protocol at the time of collection of the non-objection. * patients covered by articles l1121-5 to 1121-8 of the french public health code (minors, adults under guardianship or trusteeship, patients deprived of their liberty, pregnant or breast-feeding women), * any other reason which, in the investigator's opinion, could interfere with the evaluation of the research objectives.
the development of upper extremity rehabilitation program using virtual reality for the stroke patients

Conditions: Upper Extremity Dysfunction After the Stroke

Summary: using the upper extremity rehabilitation program developed by virtual reality would help the recovery upper extremity function in patients with stroke.

this randomized, double-blind, controlled trial included 24 patients with ischemic stroke. the intervention group received 30 min of conventional occupational therapy (ot) and 30 min of the mobile upper extremity rehabilitation program using a smartphone and a tablet pc (mou-rehab). the controls (n = 12) received conventional ot alone for 1 h per day. rehabilitation consisted of 10 sessions of therapy, 5 days per week, for 2 weeks. the outcome measures (fugl-meyer assessment of the upper extremity \[fma-ue\], brunnstr¨om stage \[b-stage\] for the arm and the hand, manual muscle testing \[mmt\], modified barthel index \[mbi\], euroqol-5 dimension \[eq-5d\], and beck depression inventory \[bdi\]) were assessed at the beginning and end of treatment, and at 1 month. user satisfaction was evaluated by a qestionnaire.

Eligibility criteria:
inclusion criteria: * ischemic or hemorrhagic stroke confirmed by brain imaging study * upper extremity dysfunction * possible to use a simple device exclusion criteria: * delirium, confusion or other evidence related to the consciousness * uncontrolled medical or surgical disease * unable to command to the order due to severe cognitive impairment * visual impairment * unable to sit
the six-minute stepper test as an outcome measure of exercise tolerance during pulmonary rehabilitation in with chronic obstructive pulmonary disease (copd) patients(stepper)?

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the aim of this study is to show if the six-minute stepper test (st6) is a sensible marker of exercise tolerance evolution during a pulmonary rehabilitation program in people with all stages of severity of chronic obstructive pulmonary disease (copd).

currently, the reference test in assessing functional capacity in copd patients during pulmonary rehabilitation is the six-minute walking test (6mwt). however, the realization of the 6mwt requires a 30m-long corridor, according to the american thoracic society guidelines. lack of sufficient space can prevent the realization of 6mwt, especially for private practitioner pulmonologists, and also in hospitals. the six-minute stepper test (st6) which can be performed in a normal room, should be an interesting alternative.

Eligibility criteria:
inclusion criteria: * patient with copd wtih all stages of severity * hospitalized in the pulmonary rehabilitation unit in the hospital of morlaix, with a 3 weeks pulmonary rehabilitation course exclusion criteria: * pneumonectomy, lobectomy less than 6 months * orthopedic problem * balance disorder * weight \> 110kg

Keywords: copd st6: the six minute stepper test conventional respiratory rehabilitation pulmonary rehabilitation
efficacy, pharmacokinetics and safety of org 25969 in subjects with normal or impaired renal function (19.4.304)(p05948)(completed)

Conditions: Anesthesia, General

Summary: the purpose of this study is to compare the efficacy and pharmacokinetics of org 25969 in subjects with normal or impaired renal function and to evaluate the safety of org 25969 in subjects with impaired renal function.


Eligibility criteria:
inclusion criteria: * asa class 1 - 3 for renally impaired patients, asa class 1-2 for control group * age at least 18 years * scheduled for general anesthesia without further need for muscle relaxation other than one single dose of 0.6 mg.kg-1 rocuronium * scheduled for surgical procedures in the supine position * written informed consent * creatinine clearance (clcr) \< 30 ml/min for renally impaired group, clcr = 80 ml/min for control group exclusion criteria: * known or suspected neuromuscular disorders impairing nmb * known or suspected (family) history of malignant hyperthermia * known or suspected allergy to narcotics, muscle relaxants or other medication used during general anesthesia * use of medication known to interfere with nmba based on the dose and the time of administration, such as antibiotics, anticonvulsants and mg2+ * pregnancy * childbearing potential without using any of the following methods of birth control: condom or diaphragm with spermicide, vasectomized partner ( \> 6 months), intrauterine device, abstinence * breast-feeding * prior participation in any trial with org 25969 * participation in another clinical trial, not pre-approved by nv organon, within 30 days of entering into trial 19.4.304, or for the uk only: participation in another clinical trial, within 30 days of entering into trial 19.4.304.
double-blind trial of miglitol in type 2 diabetic patients treated with biguanide

Conditions: Type 2 Diabetes Mellitus

Summary: the purpose of this study is to evaluate the clinical efficacy and safety of miglitol in patients with type2 diabetes mellitus treated with biguanide.


Eligibility criteria:
inclusion criteria: * type 2 diabetic patients treated with biguanide * criteria for postprandial plasma glucose and hba1c are met exclusion criteria: * type 1 diabetes * patients treated with other antidiabetic drugs or insulin

Keywords: alpa-glucosidase inhibitor,biguanide
severe acute respiratory syndrome coronavirus type 2 (sars-cov-2)-related multiple sclerosis (ms) vaccination study

Conditions: Multiple Sclerosis (MS)

Summary: the primary objective of this study is to document immunization status of ms participants after sars-cov-2-vaccinations and to evaluate possible effects of disease modifying therapy (dmts) on the immune status. the secondary objectives of the study are to document longevity of immunization status of ms participants after sars-cov-2-vaccinations and to evaluate possible effects of dmts on the immune status, to assess anti sars-cov-2 antibody titers regarding amount and persistence, to document immunization status of ms participants after repeated sars-cov-2-vaccinations and to evaluate possible effects of dmts on the immune status, to document vaccine types used in ms population in germany and to describe tolerability of sars-cov-2 vaccines according to participant's assessment.


Eligibility criteria:
key inclusion criteria: * diagnosis of ms according to mcdonald criteria (2018) * sars-cov-2 vaccination is planned (within the upcoming 90 days), underway (only one of two vaccinations received) or only recently completed (in the last 6 weeks) or sars-cov-2 vaccination has been completed \>6 weeks but an additional vaccination is planned within the upcoming 30 days key exclusion criteria: * participant cannot be regularly followed up for organizational or geographic reasons * participant is unwilling to get vaccinated against sars cov-2 virus note: other protocol defined inclusion/exclusion criteria may apply.

Keywords: sars-cov2 vaccination
outcomes of urological surgery during periods of social covid-19 containemnt: is it reasonable to limit access to surgical care for all?

Conditions: Surgery; Complication of Surgical Procedure; COVID

Summary: the french healthcare system has been strongly mobilized since the start of the covid-19 epidemic to take care of patients with covid-19. this should not overlook the fact that some treatments, surgeries and examinations of non-covid-19 patients must imperatively be maintained according to the assessment of their risk-benefit balance. in context, it appears that this is not always the case. in addition to the necessary social containment measures, there are general limitations on patient access to the operating theater, neglecting the individual interest of naive non-covid-19 patients. certain studies which report a higher and earlier risk of death of undetected and ultimately operated covid-19 patients has reinforced, as a precaution, the massive deprogramming of naive patients and the restrictive access of surgical care for all. we believe that this could lead to a risk of delayed treatments and renunciation of care for naive patients who should not be considered at risk a priori in the event of surgery. the individual clinical and local health context should be first considered for appropriate surgical decision-making. as such, the french department of health and human services (dgs) has given general guidelines regarding the maintenance of follow-up and care for non-covid-19 patients in this context of containment and major mobilization of health care professionals to care for people with covid. surgeries which could not be postponed because of the patient's status or if their postponement exposed to a significant risk of loss of chance, if needed in the light of the recommendations issued by learned societies, were concerned. in this sense, the investigator have selected the naive covid-19 patients from nice hospital who should benefit from elective or urgent urological surgeries, taking into account their individual risk and the territorial epidemic rate. their rate of icu stays following their surgery has been analysed and their surgical follow-up outcomes during the epidemic period evaluated, according to the anti-covid-19 measures established in nice hospital by comparing them to an earlier period without covid-19.


Eligibility criteria:
inclusion criteria: * naive patient for elective or emergency urological surgery exclusion criteria: * minor less than 18 year old
active and placebo controlled study to test the efficacy and safety of an aspirin-lidocaine lozenge in the symptomatic treatment of sore throat associated with a common cold

Conditions: Common Cold; Pharyngitis; Tonsillitis

Summary: the purpose of this study is to investigate the analgesic efficacy of a single dose of a fixed combination of 500 mg aspirin (acetylsalicylic acid) and 4 mg lidocaine in adult patients with sore throat associated with a common cold in comparison to a single treatment with 500 mg aspirin or 4 mg lidocaine alone as well a placebo (treatment without any active ingredient). the combination of aspirin and lidocaine in a single lozenge is expected to provide relief from sore throat pain by sequential action. a very fast inset of action will be achieved by the locally acting lidocaine and a long duration of action will be achieved by the systemically acting aspirin.


Eligibility criteria:
inclusion criteria: * males and females of at least 18 years of age * onset of common cold within the last 3 days (12 to 72 hours) * history of at least 4 symptoms associated with urti in the last 24 hours out of runny nose, stuffy nose, sneezing, wet cough, dry cough, sweating, earache, ear fullness, sinus pressure/pain, head heaviness, muscle aches and pains, feverish discomfort, chills, hoarseness, sore throat, scratchy throat and headache as documented in the history of urti * current sore throat confirmed by a score ≥ 6 on a 11-category vertical ordinal scale for sore throat pain * findings that confirmed the presence of tonsillopharyngitis exclusion criteria: * pregnancy (i.e. positive pregnancy test at baseline) * breastfeeding * history of hypersensitivity (allergic reaction) to asa or any other nsaid * history of hypersensitivity (allergic reaction) to lidocaine * history or acute state of peptic ulceration or gastrointestinal bleeding * history of bleeding tendency * history of asthma * clinical diagnosis of chickenpox or influenza * history or presence of severe liver or kidney disease * intake of short-acting analgesics (e.g. asa, paracetamol, ibuprofen, diclofenac) either as a single ingredient or as part of a combination cold product in the last 6 hours, or intake of long-acting analgesics (e.g. naproxen) in the last 12 hours, or intake of any other nsaid in the last 24 hours * use of any local or systemic short-acting cough and cold preparation (e.g. decongestant or antihistaminic drug) in the last 12 hours * use of any cough or sore throat lozenges/candies or any menthol-containing product (including mentholated tissues) in the last 6 hours * current intake or requirement of any prescription medication for the current treatment of acute respiratory tract illness * administration of anticoagulants in the last 7 days * inability to breathe through the nose or a history of chronic mouth breathing * presence of any severe concomitant disease or condition which, in the opinion of the investigator, is a reason for exclusion, e.g. serious cardiovascular diseases (in particular arrhythmias), treatment with antiarrhythmics or methotrexate

Keywords: sore throat
clinical evaluation of new computerized labor monitoring system

Conditions: Obstetrics; Labor

Summary: the study is an open label feasibility study. the purpose of the study is to evaluate the ease of use of the cervical itr in terms of duration of attachment and number of detachments.

every year, millions of babies are born worldwide. yet, despite great advances in medical technology, the method used to obtain the most critical parameter in labor management - cervix dilatation, remains a vaginal (manual) examination. this vaginal examination, intended to estimate the dilatation of the cervix and the progress of the baby's head, is inaccurate, non-continuous and involves the risk of infection to both fetus and mother. it is also uncomfortable to the mother. the consequences of infections or delayed treatment may range from simple complications to irreversible damage. early detection of abnormal patterns of labor progress could prevent complications and shorten the labor process and hospitalization, thereby saving both aggravation and cost. to truly manage the labor process, a labor management system is required. such a system is expected to provide the obstetrical staff with the flow of accurate, continuous, real-time information, such as cervix dilatation.

Eligibility criteria:
inclusion criteria: * laboring women referred to the maternity center in active labor (3cm dilatation and contractions). * gestational age 37-42 weeks. (ga) * single fetus * subjects who understood, agreed and signed the informed consent form exclusion criteria: * women with abnormal placentation (placenta previa) * women with coagulation abnormalities. * abnormal fetal presentation (breech presentation) * maternal history of hiv and/or blood transmitted hepatitis and/or active genital herpes. * preterm premature rupture of membranes. * need for immediate delivery (cord prolapsed or suspected placental abruption

Keywords: labor obstetric cervical dilatation