Kornimate/medical-research-clean huggingface dataset:
personal patient profile - prostate (p3p) ii: effectiveness-implementation trial in diverse health care networks

Conditions: Prostate Cancer

Summary: the purpose of this study is to determine whether using the p3p website can increase decisional preparation and satisfaction, and decrease decisional conflict, in men deciding how to manage early stage prostate cancer.


Eligibility criteria:
inclusion criteria: * biopsy-proven diagnosis of prostate cancer, t1 or t2 of any risk level * biopsy done at enrolling site * upcoming appointment with consulting specialist at enrolling study site * able to read, write, understand english exclusion criteria: * two or more post-biopsy specialist consults * begun treatment (or active surveillance)

Keywords: prostate cancer decision
physiotherapy in post covid-19 syndrome patients

Conditions: Post-COVID-19 Syndrome

Summary: patients who have undergone covid-19 infection often have long-term sequelae. one of the most prevalent sequelae is pain. the main objective of this research is to investigate the efficacy of a cognitive behavioral principles-based treatment program in fear avoidance beliefs, disability, pain catastrophizing and pain interference.


Eligibility criteria:
inclusion criteria: * patients of both sexes. * agreed to participate. * post covid-19 patients meeting the who definition for this disease. exclusion criteria: * neurological or orthopaedic pathologies that limited voluntary movement. * cognitive impairment that prevented them from understanding and answering the questionnaires. * patients suffering from a reinfection with sars-cov-2. * patients who had been hospitalized due to covid-19 infection. * patients who had pre-existing chronic pain according to the current iasp definition.
effect of audio book applıcatıon on patıents blood pressure, pulse rate and anxıety levels before total knee replacement surgery

Conditions: Stress

Summary: before the tdp surgery, the anxiety levels of the patients in the experimental group will be measured by listening to an audio book.

before total knee prosthesis surgery, patients will have their blood pressure, pulse and anxiety levels measured before the surgery. patients in the experimental group will listen to an audiobook for 20 minutes. the selected book will be played via wireless headphones. the researcher will check the battery level of the headphones and charge it when necessary. in this way, the headphones will be ready for the next patient. a smartphone with spotify mobile application installed, which the researcher is a member of, will be used for the audiobook application. the connection between the headphones and the audiobook will be provided via bluetooth. the patient will be present from the moment they start listening to the audiobook section, and if they experience any hearing problems or if there is an attempt to stop listening, immediate intervention will be made. necessary interventions will be made for patients who experience interruptions during listening to listen again. after each application, the headphones will be cleaned with an antiseptic solution containing chlorhexidine 2%. the patient will be asked to rest for 10 minutes after the audiobook application. at the end of 10 minutes, the patient will be filled with an aökö and the patient's blood pressure and pulse will be measured and recorded. when measuring patients' blood pressure, the same blood pressure monitor with calibrated cuff, manometer, and stethoscope will be used, and when measuring pulse, the saturation device data will be used and recorded.

Eligibility criteria:
inclusion criteria: * must be between 40-80 years of age, * patients must be conscious and able to communicate, * individuals who volunteer to participate in the study, * no hearing problems, * individuals who will undergo tka surgery, * can understand turkish, * patients must have elective (planned) surgery (must have been hospitalized at least 2 hours before surgery). exclusion criteria: * refusing to participate in the study, * any communication barrier, * cancellation of tka surgery for any reason.

Keywords: anxiety blood pressure before surgery total knee prosthesis audio book
early tips in real life for patient admitted to intensive care unit

Conditions: Esophageal Varicose Veins

Summary: acute esophageal variceal bleeding (aevb) is a serious complication of cirrhosis, with high morbidity and mortality. the latest european recommendations(1) recommend the early implementation, within 72 hours following esophageal variceal bleeding, of a transhepatic porto-systemic shunt set up by transjugular route (tips) called "early tips" in patients at high risk of recurrence, i.e. child c\<14 or child b with active bleeding at the time of endoscopy. the implementation of early tips appears to improve survival without transplantation in these patients, although the benefit among child b patients without active bleeding has yet to be demonstrated. renal failure is a determining factor in the prognosis of the cirrhotic patient. for patients with refractory ascites, or type 2 hepato-renal syndrome (i.e. chronic renal failure related to portal hypertension), the use of tips is recommended. although a few studies with low levels of evidence have reported a benefit in the placement of tips in hepato-renal syndrome type 1 (i.e. acute renal failure related to portal hypertension), the european recommendations do not recommend the use of tips in this context due to lack of studies on the subject. some studies have shown an improvement in renal function after performing tips in refractory ascites. to date, no studies have evaluated the impact of the implementation of early-tips on renal function in intensive care patients. the investigators would like to evaluate the impact on survival without liver transplantation on d28 of the implementation of early-tips in cirrhotic patients with aevb requiring icu hospitalization, compared to standard treatment (medical and endoscopic).

using electronic patient data monitoring systems, the investigators reviewed all patients with a diagnosis of cirrhosis admitted to icus at the nantes university hospital, and departmental hospital of vendée from january 1, 2012, to december 31, 2018. for enrolled patients, general clinical characteristics were collected. patients were categorized into two groups according to the type of treatment performed: early tips or standard treatment.

Eligibility criteria:
inclusion criteria: adult patients (age \>18 years) with cirrhosis admitted in intensive care unit cirrhosis child b or child c with acute esophageal variceal bleeding confirmed by endoscopy. exclusion criteria: patients under guardianship patients with a decision to limit care at the admission patients with already a tips. patients with a invasive multifocal hepatocellular carcinoma pregnancy
skin prick test for the diagnosis of food allergy- a comparison of different commercial extracts and raw food

Conditions: Food Allergy

Summary: immediate food allergy is , sometimes , a life threatening situation . diagnosis is done by skin prick test with commercial extracts. nevertheless, some of the extracts are not optimal and reproduce false negative results (no allergy) in patients with history highly suggestive of allergic reaction. the aim of this study is to compare the reproducibility of different commercial extracts and raw food in patients with convincing history of acute allergic symptoms related to food .


Eligibility criteria:
inclusion criteria: * suspected immediate allergic reaction to food exclusion criteria:none

Keywords: skin test raw food commercial extract
plant-based diets and risk of cancer in the adventist health study-2

Conditions: Cancer, Breast; Cancer, Colorectal; Cancer, Prostate

Summary: the adventist health study-2 is a long-term study, exploring the links between lifestyle, diet, and disease outcomes among seventh-day adventists. more than 96,000 church members from the u.s. and canada are participating in the current study, ahs-2, conducted by researchers at the loma linda university school of public health.

the adventist health study-2 (ahs-2) is a large national cohort of 96,000 seventh-day adventists in the u.s. and canada. the study is searching for associations between diet and risk of common and medium frequency cancers (breast, prostate, colorectal, lung, uterus, pancreas, melanoma of skin). this cohort is unusual in that about half are vegetarian, many eat soy at asian levels, and many have very low or absent dairy intake while others eat normal amounts of dairy. thus observations on these people, many of whom have contrasting dietary habits, may provide insights about diet and cancer, so supporting dietary changes that could be readily adopted by many.

Eligibility criteria:
inclusion criteria: * member of a seventh-day adventist church \>30 years of age ability to read english live in the us or canada exclusion criteria: * less than 30 years of age * church members who did not complete the baseline questionnaire. * incarcerated or institutionalized people * non-english speakers

Keywords: seventh-day adventists vegetarian mortality cancer dietary pattern soy consumption dairy consumption plant-based
small volume fluid challenge as a predictor of fluid responsiveness in patients with circulatory failure

Conditions: Circulatory Failure

Summary: assessment of intravascular volume status is difficult in critically ill patients. evidence suggests that only 50% of hemodynamically unstable patients respond to a fluid challenge. moreover, if cardiopulmonary function cannot compensate for the increase in preload, fluid loading may compromise microvascular perfusion and oxygen delivery and cause or aggravate peripheral and pulmonary edema. inappropriate fluid expansion can increase morbidity and mortality thus making it important to accurately assess fluid responsiveness in critically ill patients. the volume responsiveness can be defined as a 15% increase in stroke volume (sv) or cardiac output (co) after a 500-ml infusion. this study tested whether echocardiographic parameters can predict fluid responsiveness in critically ill patients following a low volume 100-ml crystalloid solution infusion over 1 minute.

fifty-four adult patients with circulatory failure were recruited for the study. as a routine work in adult critical care unit at menoufia university hospital for patients with circulatory failure, a 100 ml bolus of normal saline solution was given to the patient over 1 minute through a central venous catheter or jugular cannula. for prediction of responders, echocardiographic parameters were recorded1 minute after bolus administration. the remaining 400 ml of normal saline solution was infused at a constant rate over 10 minutes, and echocardiographic parameters were recorded again. the mean echocardiographic measurements over three consecutive respiratory cycles were recorded along with heart rate hr, systolic, diastolic and mean arterial pressures, central venous pressure, and temperature also mechanical ventilation parameter (tidal volume, respiratory rate and peep) for each patient. patients with an increase in co after a 100 ml or total 500-ml infusion over 10 minutes (δco500) of 15% or more were classified as responders (rs) and those without an increase in co was classified as non-responders

Eligibility criteria:
inclusion criteria: * patients with acute circulatory failure * mechanically ventilated \& sedated.(tidal volume 6-8 ml/ kg, peep 5 mmhg, richmond agitation-sedation scale rass (r) score from zero to -3). * systemic inflammatory response syndrome * septic shock * controlled massive hemorrhage exclusion criteria: * age of less than 18 years * cardiomyopathy * pulmonary edema * morbid obesity * pregnancy * increased intracranial tension * valvular heart disease * myocardial ischemia or infarction before the study
study to evaluate the safety and antiviral activity of remdesivir (gs-5734™) in participants with severe coronavirus disease (covid-19)

Conditions: COVID-19

Summary: the primary objective of this study is to evaluate the efficacy of 2 remdesivir (rdv) regimens with respect to clinical status assessed by a 7-point ordinal scale on day 14.


Eligibility criteria:
key inclusion criteria: * willing and able to provide written informed consent, or with a legal representative who can provide informed consent, or enrolled under international conference on harmonization (ich) e6(r2) 4.8.15 emergency use provisions as deemed necessary by the investigator (age ≥ 18), or willing and able to provide assent (age ≥ 12 to \< 18, where locally and nationally approved) prior to performing study procedures * aged ≥ 18 years (at all sites), or aged ≥ 12 and \< 18 years of age weighing ≥ 40 kg (where permitted according to local law and approved nationally and by the relevant institutional review board (irb) or independent ethics committee (iec)) * severe acute respiratory syndrome coronavirus (sars-cov)-2 infection confirmed by polymerase chain reaction (pcr) test ≤ 4 days before randomization * currently hospitalized * peripheral capillary oxygen saturation (spo2) ≤ 94% or requiring supplemental oxygen at screening key exclusion criteria: * participation in any other clinical trial of an experimental treatment for covid-19 * concurrent treatment with other agents with actual or possible direct acting antiviral activity against sars-cov-2 is prohibited \< 24 hours prior to study drug dosing * evidence of multiorgan failure * mechanically ventilated \[including veno-venous (v-v) extracorporeal membrane oxygenation (ecmo)\] ≥ 5 days, or any duration of veno-arterial (v-a) ecmo. * alanine aminotransferase (alt) or aspartate aminotransferase (ast) \> 5 x upper limit of normal (uln) * creatinine clearance \< 50 ml/min using the cockcroft-gault formula for participants ≥ 18 years of age {cockcroft 1976} and schwartz formula for participants \< 18 years of age note: other protocol defined inclusion/exclusion criteria may apply.
4g/5g polymorphism of plasminogen activator inhibitor-1 gene and disseminated intravascular coagulation in severe sepsis and septic shock

Conditions: Severe Sepsis

Summary: data on 4g/5g polymorphism of plasminogen activator inhibitor-1 (pai-1) gene are limited in asian patients with sepsis. therefore, the investigators aim to prospectively investigate the incidence of 4g/5g polymorphism and its relationship with disseminated intravascluar coagulatin in patients with severe sepsis and septic shock.


Eligibility criteria:
inclusion criteria: * adult patinents aged \> 18 years, patients satisfying the criteria by 2008 surviving sepsis campagin, patients who are determined as having a sepsis within 24 hours of icu stay exclusion criteria: * do-not-resuscitate, cardiopulmonary resuscitation, icu stay \< 1 day, refusal to participate in the study, hematologic malignancy or liver cirrhosis (child c), congenital abnormality in coagulation system, transfer from other icus or hospitals

Keywords: polymorphism, plasminogen activator inhibitor, disseminated intravascular coagulation,
abod2011 in patients with advanced solid tumors progressed after standard systemic therapy

Conditions: Patients With Advanced Solid Tumors

Summary: based on the activation and regulation of immune system by cytokines, mrna encoding cytokines has become one of the important directions of mrna tumor drug development. this product (abod2011) is a new generation mrna product for intratumoral injection. the primary objective of this study is to assess the safety and tolerability, of abod2011 in patients with advanced solid tumors that progressed after standard systemic therapy.


Eligibility criteria:
inclusion criteria: 1. 18 years and older. 2. understand and voluntarily sign the informed consent form (icf). 3. histopathologically confirmed recurrent or metastatic solid tumors. 4. failure of prior systemic standard of care, or intolerance to severe toxicity, or lack of standard of care. 5. presence of at least one measurable lesion as assessed by recist version 1.1. 6. at least one superficial or deep lesion for intratumoral administration and biopsy. 7. sufficient organ functions. 8. eastern cooperative oncology group (ecog) performance status ≤ 1. 9. weight \> 30 kg. 10. expected survival longer than 12 weeks. 11. evidence of menopause in female patients, or for women of childbearing potential: negative for urine or blood pregnancy. exclusion criteria: 1. any systemic anti-tumor therapy, within 28 days prior to the first dose. 2. radiotherapy within 14 days prior to first dose. 3. use of immunosuppressants. 4. major surgery within 28 days. 5. inadequately controlled diseases. 6. active autoimmune and inflammatory diseases. 7. clinically symptomatic central nervous system tumors or metastases. 8. toxicity of prior anti-tumor therapy is still nci-ctcae ≥ 2. 9. other malignancies within the previous 5 years with the exception of cured basal cell carcinoma of the skin, superficial bladder cancer, carcinoma in situ of the breast, and carcinoma in situ of the cervix. 10. active infections. 11. other conditions that may increase the risk associated with the study drug, or affect the study compliance, etc., which, in the opinion of the investigator, are not suitable for participation in the study.
taste acceptability of tomato-soy-arugula seed beverages in men with prostate cancer

Conditions: Prostate Carcinoma

Summary: this study is a sensory analysis of several different formulations of a novel tomato-soy-arugula seed beverage in men with prostate cancer. eating a diet rich in a variety of fruits and vegetables has been associated with decreased risk of a variety of diseases, including prostate cancer. mixed vegetable beverages may be useful in prostate cancer survivorship.

primary objectives: i. to evaluate the sensory acceptability of a novel tomato-soy-arugula seed beverage in men with prostate cancer. outline: patients receive 4 tomato-soy beverages and 3 labeled arugula seed powder portions. patients add 1 arugula seed powder portion to each of 3 tomato-soy beverages immediately prior to consumption and they consume 1 beverage without the powder. after each beverage tasting, patients complete a survey on the sensory acceptability of the sample.

Eligibility criteria:
inclusion criteria: * have a prostate cancer diagnosis * not be allergic to tomato or tomato products * not be allergic to soy or soy related products * not be allergic to any cruciferous vegetables (e.g.: broccoli, cauliflower, kale, brussels sprouts, arugula/rocket, bok choy, etc.) * voluntarily agree to participate and read the informed consent documents

Keywords: tomato-soy-arugula
invasive measurement of axial plaque stress, the pilot study

Conditions: Coronary Artery Disease

Summary: in this study, the investigators sought to evaluate the feasibility of estimating external hemodynamic stress acting plaque with the use of invasively measured hemodynamic data from pressure wire pullback tracing. in addition, the investigators will also evaluate detailed plaque geometry and vulnerability using optical coherence tomography along with the hemodynamic stress.

it has been well known that mechanism of acute coronary syndrome is plaque rupture and occlusion of coronary artery by this plaque rupture. although current risk assessment for plaque rupture have mainly focused on evaluation of plaque vulnerability. however, according to the general mechanism of material failure, plaque rupture occurs whenever the external hemodynamic stress exceeds the durability of the plaque. recently, we evaluated the axial plaque stress, which is axial component of total traction acting on the plaque, and showed that the axial plaque stress possess significantly higher magnitude than previously known wall shear stress. however, the axial plaque stress in our previous research was measured with computational flow dynamics analysis using coronary artery model from coronary ct angiography. in this study, we sought to evaluate the feasibility of estimating external hemodynamic stress acting plaque with the use of invasively measured hemodynamic data from pressure wire pullback tracing. in addition, we will also evaluate detailed plaque geometry and vulnerability using optical coherence tomography along with the hemodynamic stress.

Eligibility criteria:
inclusion criteria: * 1. patients with angina pectoris who are scheduled to do invasive coronary angiography. * 2. patients who have moderate (40-70%) stenosis at proximal or mid-portion of major coronary arteries. * 3. pressure wire pullback tracing and optical coherence tomography ware successfully performed exclusion criteria: * 1. stenosis at distal coronary or small vessel. * 2. patients who don't have moderate (40-70%) stenosis at proximal or mid-portion of major coronary arteries. confirmed by invasive coronary angiography. * 3. inadequate quality of optical coherence tomography * 4. no data of fractional flow reserve or pressure wire pullback tracing or inadequate data of fractional flow reserve or pressure wire pullback tracing

Keywords: optical coherence tomography axial plaque stress wall shear stress vulnerability
evaluation of clinical and pathological characteristics and routine treatment of patients with prostate cancer

Conditions: Prostate Cancer

Summary: to evaluate clinical and pathological characteristics and treatment protocol and outcomes of patients with prostate cancer in 2 centers of asyut from 2013 to 2023

inclusion criteria : * male patient , age ≥ 40 yo * diagnosed as prostate cancer from ( 2013- 2023 ) proved by biopsy in south egypt cancer institute "seci" \& asyut clinical oncology department * newly diagnosed/ metastatic at presentation * ecog 0-4 • exclusion criteria: * having other types of malignancy.

Eligibility criteria:
inclusion criteria: * male patient , age ≥ 40 yo * diagnosed as prostate cancer from ( 2013- 2023 ) proved by biopsy * newly diagnosed/ metastatic at presentation * ecog 0-4 exclusion criteria: * having other types of malignancy.
yoga versus health education for the treatment of persistent fatigue in patients with post covid-19 syndrome

Conditions: Post-COVID-19 Syndrome; Fatigue Post Viral

Summary: evaluation of the short- and medium-term effect of a yoga intervention in addition to routine care compared to health education in addition to routine care on fatigue in patients with post covid syndrome.


Eligibility criteria:
inclusion criteria: * confirmed covid-19 diagnosis * follow-up symptoms of ≥ 12 weeks * persistent fatigue (scores ≥4 on the binomial chalder fatigue scale). * self-assessment that fatigue was a consequence of covid-19 disease * age 18-65 years exclusion criteria: * chronic medical conditions or regular use of medications associated with fatigue * indication of health cause of fatigue other than post-covid. * indication of other factors as the main cause of fatigue * physical limitations that do not allow participation in the yoga intervention * pregnancy, breastfeeding * concurrent participation in other clinical trials * current yoga practice

Keywords: fatigue covid