Kornimate/medical-research-clean huggingface dataset:
patient-centered mobile health intervention to improve self-care in patients with chronic heart failure

Conditions: Heart Failure

Summary: approximately 6.5 million people have heart failure (hf) in the united states, and 960,000 new cases are reported each year. hf is one of the most common hospital diagnosis among older adults. about 40% of patients are readmitted within 1-year following their first admission for hf and hospitalization accounts for approximately 80% of the costs of hf management. this pilot study aims to assess the feasibility, acceptability, and preliminary efficacy of a patient-centered mobile health (mhealth) technology intervention in older adults with chronic heart failure.

this is a single site, two-arm, pilot randomized controlled trial that aims to examine the feasibility, acceptability and preliminary efficacy of a mobile phone-based intervention compared to usual care in older adult patients with hf (≥50 years). forty (n=40) patients from the university of illinois hospital \& health sciences system will be enrolled in the study, randomly assigned to the intervention or usual care group, and followed for 60 days. patients in the intervention group will receive the heart failure health storylines mobile app developed by self care catalysts in collaboration with the heart failure society of america, three connected health devices from fitbit and nokia that interface with the mobile app, and tailored text-messages targeting health beliefs, self-care efficacy, and knowledge about hf. the control group will receive standard care which involves patient education and outpatient follow up with physical and laboratory examinations as needed. the primary study outcome is change in self-care and quality of life. secondary outcomes include hospital re-admissions and emergency room visits.

Eligibility criteria:
inclusion criteria: * inpatients or outpatients with a diagnosis of hf as defined by the international classification of diseases (icd-10) codes * stage c, nyha i, ii or iii * ≥ 40 years of age * own a smartphone with text-messaging and internet plan * ability to speak and read english * live within 30 miles from ui health exclusion criteria: * on an active waiting list for implanted ventricular assist device or heart transplant * advanced renal disease (dialysis or creatinine \>4.0mg/dl) * end-stage hf (hospice candidate) * active cancer * individuals who are not their own primary caregiver * discharge to a setting other than home * patients with baseline montreal cognitive assessment (moca) score of \< 22

Keywords: heart failure mhealth smartphone wearable electronic devices text messaging self-management self-care
ly293111 in treating patients with advanced solid tumors

Conditions: Unspecified Adult Solid Tumor, Protocol Specific

Summary: rationale: drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. purpose: phase i trial to study the effectiveness of ly293111 in treating patients who have advanced solid tumors.

objectives: i. determine the maximum tolerated dose of ly293111 in patients with advanced solid tumors. ii. determine the safety profile and pharmacokinetics of this regimen in these patients. iii. determine the antitumor activity of this regimen in these patients. outline: this is a dose escalation study. patients receive oral ly293111 twice daily. treatment continues for a maximum of 6 months in the absence of disease progression or unacceptable toxicity. cohorts of 3-6 patients receive escalating doses of ly293111 until the maximum tolerated dose (mtd) is determined. the mtd is defined as the dose preceding that at which 2 of 3 or 6 patients experience dose limiting toxicity. additional patients are treated at the mtd. patients are followed at 30 days. projected accrual: approximately 24 patients will be accrued for this study.

Eligibility criteria:
disease characteristics: histologically or cytologically confirmed advanced and/or metastatic solid tumor for which no curative therapy exists no hematologic malignancies measurable or evaluable disease no known cns metastases patient characteristics: age: 18 and over performance status: ecog 0-2 life expectancy: at least 12 weeks hematopoietic: absolute neutrophil count at least 1,500/mm3 platelet count at least 100,000/mm3 hepatic: bilirubin no greater than 1.5 times upper limit of normal (uln) alt and ast no greater than 2.0 times uln renal: creatinine no greater than 1.5 times uln other: not pregnant or nursing negative pregnancy test fertile patients must use effective contraception during and for 3 months after study no concurrent systemic disorder that would preclude study no active infection prior concurrent therapy: biologic therapy: at least 4 weeks since prior biologic therapy and recovered no concurrent immunotherapy chemotherapy: no more than 3 prior chemotherapy regimens for metastatic disease at least 4 weeks since prior chemotherapy (6 weeks for mitomycin and nitrosoureas) and recovered no other concurrent chemotherapy endocrine therapy: at least 4 weeks since prior anticancer hormonal therapy and recovered no concurrent anticancer hormonal therapy radiotherapy: at least 4 weeks since prior radiotherapy and recovered no concurrent radiotherapy surgery: not specified other: at least 4 weeks since prior investigational therapy no other concurrent experimental medications

Keywords: unspecified adult solid tumor, protocol specific
timing of endoscopy for acute variceal bleeding in patients with cirrhosis

Conditions: Cirrhosis, Liver; Portal Hypertension; Varice Bleed

Summary: cirrhotic patients with avb across 34 university medical centers in 30 cities in china from february 2013 to may 2020 who underwent endoscopy within 24 hours were included in this study. patients were divided into an urgent endoscopy group (endoscopy \<6h after admission) and an early endoscopy group (endoscopy 6-24h after admission). outcomes included the incidence of 5-day rebleeding, in-hospital mortality, need for intensive care unit (icu) and the length of hospital stay after the endoscopy management. multivariable analysis was performed to identify risk factors for rebleeding. a propensity score matching (psm) analysis was performed to achieve a balance at baseline between the urgent and early groups.


Eligibility criteria:
inclusion criteria: * established diagnosis of cirrhosis (based on liver biopsy or the combination of clinical, biochemical, and imaging findings) * witnessed or reported evidence of gastrointestinal haemorrhage (hematemesis, melenemesis, or hematochezia) * esophageal or gastric varices confirmed endoscopically as the source of bleeding exclusion criteria: * severe dysfunction of a major extrahepatic organ (e.g., heart failure, pulmonary disease, and terminal malignancy except hepatocellular carcinoma) * history of endoscopic therapy for varices (ligation or sclerotherapy) within three months * incomplete or missing data
different preoxygenation methods in cesarean section

Conditions: Hypoxia; Hyperoxia

Summary: the study aimed to evaluate different preoxygenation methods (tidal volume for 3 minutes and 4 deep breaths) in pregnant women with oxygen reserve index (ori). after the routine monitoring of healthy asa ii pregnant patients between the ages of 18-45, different preoxygenation methods will be applied, and the oxygen status of the patients will be compared with ori monitoring.


Eligibility criteria:
inclusion criteria: * the average operation time is 30 minutes-1.5 hours. * asa ii risk class * all pregnant women with a gestational week \>36 exclusion criteria: * preeclampsia * eclampsia * fetal distress * morbid obesity * a history of malignant hyperthermia * opioid sensitivity * alcohol or drug addiction * congestive heart failure * chronic obstructive pulmonary disease * coronary artery disease * anemia, liver and kidney disease * hypovolemia, hypotension, sepsis * those who are allergic to the drugs used in the study and who are suspected of difficult intubation

Keywords: oxygen reserve index preoxygenation general anesthesia cesarean section
neuromuscular electrical stimulation in chronic heart failure patient

Conditions: Chronic Heart Failure

Summary: the purpose of the study is investigate the effects of nmes in regulation of serum il-6 and il-15 in chronic heart failure patients who received standard inpatient cardiac rehabilitation protocol

majority of chronic heart failure patients became intolerance of physical training that could limit activity. recent studies reported that neuromuscular electrical stimulation (nmes) application could increase muscle mass, oxidative enzyme, endothelial function, vo2 peak and quality of life in chronic heart failure patient. it was hypothesized that neuromuscular electrical stimulation (nmes) assisted muscle contraction in chronic heart failure patients will increase the activity of myokine (interleukin-6 and interleukin-15), that in turn will promote exercise tolerance in this patient. the aim of this study was to investigate the effects of nmes in regulation of serum il-6 and il-15 in chronic heart failure patients who received standard inpatient cardiac rehabilitation protocol. thirty chronic heart failure patients in cardiology ward that fulfilled inclusion criteria were randomized in two groups; the control group (standard inpatient cardiac rehabilitation protocol) and the intervention group (standard inpatient cardiac rehabilitation protocol and nmes). the intervention was done every day for seven days. measurement of serum il-6 and il-15 were done before and after study, and analyzed by sandwich immunoassay with monoclonal antibody.

Eligibility criteria:
inclusion criteria: * heart failure patients admitted to the hospital nyha ii-iii * no weakness of lower limbs * stable hemodynamic, already received standard treatment based on patient condition * able to follow instruction * lived at surabaya or sidoarjo * assigned the informed consent exclusion criteria: * knee osteoarthritis with knee pain that interfere the ambulation * phlebitis and active bleeding on lower limb * use vasoactive drug (such as dobutamin etc) * already receive nmes before at femoris area in last 6 weeks before admission * fracture of lower limb that interfere the ambulation * sensory deficit at lower limb * acute infection

Keywords: nmes il-6 il-15 chronic heart failure
study on the effectiveness of gastroscope operation quality control based on artificial intelligence technology

Conditions: Gastric Cancer

Summary: this study aims to construct a real-time quality monitoring system based on artificial intelligence technology.

gastroscopy plays an important role in the detection and diagnosis of upper gastrointestinal diseases. it is necessary for endoscopists to operate gastroscope according to the standardized process, in order to avoid missing early lesions. however, with the rapid increase in the number of endoscopies, the workload of endoscopists increases further. high workload reduces the quality of endoscopy, resulting in incomplete observation of anatomical parts that are easy to be missed in the process of gastroscopy. there are significant differences in the operation level of different endoscopists. therefore, carrying out artificial intelligence methods has good academic research and practical value for improving the quality of endoscopic diagnosis and treatment. artificial intelligence devices need to use a large number of endoscopic images, based on this, we intends to collect endoscopic image data from our hospitals for training and validation of the model.

Eligibility criteria:
inclusion criteria: 1. patiens aged 18 years or above undergoing gastroscopy； 2. be able to read, understand and sign informed consent； exclusion criteria: 1. patients with absolute contraindications to endoscopy examination; 2. pregnant women; 3. previous history of gastric surgery; 4. the researcher considers that the subject is not suitable for clinical trial.

Keywords: gastric cancer artificial intelligence endoscopy
effect of superior laryngeal nerve blocks on patient outcomes in laryngeal surgery

Conditions: Vocal Cord Disease; Vocal Cord Polyp; Vocal Cord Cyst

Summary: patients undergoing surgery on their vocal cord will either receive a numbing injection to their throat or a saline injection during surgery. symptoms such as how much coughing or pain patients have after surgery, as well as whether patient's voice gets better will be interrogated.


Eligibility criteria:
inclusion criteria: * patient is aged 18 years or older at time of consent * patient has suspected or confirmed benign vocal fold lesion * patient is planning to undergo direct laryngoscopy with excision of the vocal fold lesion * patient is english or spanish speaking * patient is not pregnant per self report * patient is not incarcerated exclusion criteria: * patient is not 18 years of age or older at consent date * patient does not speak english or spanish * patient is currently pregnant or plans to become pregnant prior to their study procedure * patient has a laryngeal malignancy or found to find a laryngeal malignancy on final pathology * patient will not be undergoing direct laryngoscopy with excision of lesion * patient is unable to provide consent or complete study activities * patient is incarcerated
6 minute walk test in cystic fibrosis

Conditions: Cystic Fibrosis

Summary: the purpose of this study is to determine whether the 6-minute walk test (6mwt) could be a prognostic factor for cystic fibrosis patients.

the 6-minute walk test is a simple exercise test, reproducing a daily physical activity. the utility of this test is described in several chronic lung diseases (chronic obstructive pulmonary disease, idiopathic pulmonary arterial hypertension). the distance performed during the 6mwt and / or desaturation during the 6mwt is a prognostic factor that contributes to the assessment of patients for lung transplantation indication. the 6mwt is practiced routinely in cystic fibrosis centers but its usefulness in this disease has not been shown. also the results of this test are not part of the decision-making criteria for lung transplantation. a single-center study performed in adults crcm at cochin hospital suggests the prognostic value of the 6mwt in patients with adult's cystic fibrosis. the principal objective of this study is to assess the prognostic of 6mwt as part of the cystic fibrosis. the primary endpoint will be to assess the survival without lung transplant during the follow up period of 3 years. in this context, this prognostic tool could be used to help to determine the best time to consider a lung transplant in cystic fibrosis patient.

Eligibility criteria:
inclusion criteria: * patient with cystic fibrosis (bronchiectasis with presence of two mutations in the cftr gene and / or positive sweat test. * patients aged 18 year or older. * pre-bronchodilator fev1 fev1 ≤ 60% from theoretical value: this fev1 limits is proposed following the results from our published study (martin et al. 2013) showing that desaturation during 6mwt and a distance ≤ 475m performed, are almost exclusively found in patients with fev1 ≤ 60% . * stable health status ( \>15 days after the start of treatment of a respiratory exacerbation * no indications against the walking test: left uncontrolled heart failure severe aortic stenosis acute endocarditis syncope symptomatic severe arrhythmia stable angina myocardial infarction \ 200 mm hg and / or diastolic blood pressure \>120 mm hg)) exclusion criteria: * history of lung transplant * oxygen dependence (inability to achieve a 6-minute walk test in ambient air) * any indication against walk test * pregnant women, persons deprived of liberty, person under guardianship, person in emergency situation * person not affiliated to social security system * refusal to participate in the study

Keywords: cystic fibrosis adults 6-minute walk test
irritation potential of omeza collagen matrix using modified hript

Conditions: Erythema; Sensitisation

Summary: the primary objective of this study was to assess the sensitization potential of omeza collagen matrix compared to that of a negative control based on a modified human repeat insult patch test.


Eligibility criteria:
inclusion criteria: * good general health, as assessed by medical history and brief dermal skin examination of the application site (back); * was fully informed of the risks of entering the study and was willing to provide written consent to enter the study; * was willing to follow study rules, which included: no sun exposure (for example; no swimming, sunbathing, or tanning beds), avoided activities that would cause excessive sweating, abstained from use of lotions, creams, or oils on the back area; * was willing to not change current brand of personal care products such as soaps, body washes, laundry detergents, body sprays, body spritzes, etc. while participating on the study; * was willing and able to practice an acceptable measure of contraception (i.e. birth control medication for at least 3 months prior, condom with spermicide or birth control injections,) during the study, if female of childbearing potential. to be considered female of non-childbearing potential, subject must have had a hysterectomy, tubal ligation, or had been post-menopausal for at least 1 year. exclusion criteria: * clinically significant skin disease which contraindicated participation, including psoriasis, eczema, atopic dermatitis, and active cancer; * asthma that required medication; * insulin-dependent diabetes; * known immunological disorders such as hiv positive, aids and systemic lupus * erythematosus; * treatment for any type of cancer within the last six months; * routine use (as defined by using more than 3 days in a week) of any anti-inflammatory drug (e.g., aspirin, ibuprofen, corticosteroids; 81 mg aspirin is acceptable), immunosuppressive drugs, antihistamine medication (steroid nose drops and/or eye drops are acceptable) or over-the-counter pain medication that was ingested in quantities exceeding label instructions; * use of topical drugs at patch site; * pregnancy, lactation, or planning a pregnancy (confirmed by a urine pregnancy test administered to females of childbearing potential); * medical condition which, in the investigator's judgement, made the subject * ineligible or placed the subject at undue risk; * participation in any patch test for irritation or sensitization within the last four weeks; * dermatological aberrations in or around test sites which included sunburn, extremely deep tans, uneven skin tones, tattoos, scars, excessive hair, numerous freckles, or any other disfiguration of the test site; * confirmed allergy to adhesives, bandages, or ingredients in omezatm collagen matrix; * history of anaphylaxis to matrix ingredients (e.g. fish, palm oil, hemp oil, beeswax).
building financial wellness randomized controlled trial

Conditions: Mental Disorder

Summary: this study tests a psychosocial intervention to improve financial literacy and behaviors among adults with mental illnesses.

this study is designed to test the effectiveness of a financial education curriculum, called building financial wellness (bfw), in promoting financial literacy and reducing economic strain among adults with a mental health condition. the design involves random assignment of adults who are receiving mental health services to the intervention plus services as usual, versus services as usual alone. assessments at baseline, two months post-baseline, and three months later collect data to test the null hypotheses of no difference between intervention and control conditions on outcome measures in the following domains using longitudinal mixed-effects random regression analyses: 1) financial well-being; 2) financial strain; 3) financial capability; 4) financial self-sufficiency; and 5) financial literacy.

Eligibility criteria:
inclusion criteria: * age 18+ * access to computer, tablet or smart phone and an internet connection suitable for using zoom * receiving services and/or supports for a diagnosed mental health disorder * ability to understand spoken english * interest in learning money management skills. exclusion criteria: * cognitive impairment preventing informed consent * unable to communicate in english

Keywords: financial wellness
risk prediction and therapy monitoring in patients with sars-cov-2 infection / covid 19

Conditions: SARS-CoV2; COVID

Summary: approximately 15% of patients with sars-cov-2 infection / covid-19 develop a severe clinical course. this leads to hospitalization and potentially life threatening complications such as pneumonia and respiratory failure. predictors for early detection and risk stratification are urgently needed. moreover, only scarce information is available for long-term follow-up and late complications associated with infection. we therefore aimed to find predictors for severe courses of the novel disease as well as to establish strategies for therapeutic monitoring and follow-up.


Eligibility criteria:
inclusion criteria: * sars-cov-2 infection / covid 19 exclusion criteria: * invasive ventilation * respiratory failure at admission
inhaled and intravenous milrinone in patients with severe pulmonary hypertension

Conditions: Pulmonary Hypertension Due to Left Heart Disease

Summary: the investigator compared difference between inhaled and intravenous milirinone in patiens with severe pulmonary hypertension undergoing cardiac surgery

milrinone is widely used in cardiac surgery as an inotrope and pulmonary vasodilator agent but , intravenous milrinone has been associated with systemic hypotension and increased requirement for vasoactive drugs the investigator compared difference between inhaled and intravenous milirinone in patiens with severe pulmonary hypertension undergoing cardiac surgery

Eligibility criteria:
inclusion criteria: * patients scheduled to undergo mitral valve surgery by cardiopulmonary bypass with estimated mean pulmonary artery pressure =\>55 estimated by using preoperative doppler echocardiography exclusion criteria: patients were excluded if they had surgery without cpb, preoperative hemodynamic instability (deﬁned as acute requirement for vasoactive support or mechanical device),patients with severe lv dysfunction (lv ejection fraction of less than 30% congenital heart disease, a contraindication to transesophageal echocardiography (tee), emergency surgery or re-do surgeries severe renal or hepatic disease , coagulopathy, and thromboembolic disease treated with anticoagulants
satiety response of white and brown rice compared to glucose control

Conditions: Food Selection

Summary: the investigators hypothesize that consumption of either white or brown rice will be more satiating than glucose control.

this study is an acute, randomized, repeated measures design with 20 subjects. subjects will consume 3 test breakfasts, white rice, brown rice, or glucose control, each containing 400 calories. treatments will be one week apart. after consumption of the controlled breakfast, subjects will complete visual analogue scales (vas) for satiety response. additionally, they will consume a pizza lunch and record food intake for the next 24 hours. breath gas samples will be collected to estimate fermentation of fiber in the large intestine. also, subjective data on gastrointestinal tolerance will be collected.

Eligibility criteria:
inclusion criteria: * healthy subjects exclusion criteria: * inability to consume rice for breakfast

Keywords: satiety obesity food intake