Kornimate/medical-research-clean huggingface dataset:
morphometric examination of the larynx

Conditions: Laryngeal Dimensions in Males and Females

Summary: objective: to measure laryngeal dimensions in a sample of turkish cadavers including males and females of various ages and heights. patients and methods: morphological measurement was performed on 102 laryngeal specimens. laryngeal cartilages were collected from human cadavers. all dimensions of the cartilages were measured using a thread and vernier calipers. age, sex, and height were recorded. results for men and women were compared.


Eligibility criteria:
inclusion criteria:human cadavers - exclusion criteria: -

Keywords: larynx, measurement, cadaver, turkish population
bakircay university cigli training and research hospital

Conditions: Bladder Cancer

Summary: the aim of the study is to investigate the oncological outcomes of obturator nerve blockade in patients with lateral wall localized non-muscle invasive bladder cancer

patient divided into two group.first group includes patients underwent tur-bt under only spinal anesthesia and second group includes patients underwent tur-bt under spinal anesthesia combined with ultrasound guided obturator nerve blockade.

Eligibility criteria:
inclusion criteria: * patients with lateral wall localized non muscle invasive bladder cancer exclusion criteria: * history of previous tur-bt * diagnosis of non-urothelial carcinoma * coagulopathy * history of allergic reaction to the local anesthtetic agent * presence of muscle-invasive bladder cancer * history of chemotherapy or radiotherapy before tur-bt * precence of variant histopathology * using bipolar energy for the resection of bladder tumor * presence of concomittant upper urothelial tract urothelial carcinoma * patients with the neuromusculer disease * pregnancy * history of medication effecting immune system

Keywords: obturator nerve blockade bladder cancer non-muscle invasive bladder cancer adductor contraction bladder perforation
translational cancer observational protocol

Conditions: Upper Urinary Tract Urothelial Carcinoma

Summary: observational study on relapse occurrence and on the quality of life in patients who underwent nephroureterectomy surgery

monocentric prospective and retrospective observational study on the quality of life and on the pathological status in patients who underwent nephroureterectomy surgery. oncological, psychological, sexual and quality of life-related data will be collected within a specifically created database that will allow us an easy and secure data extraction for the statistical analysis required by the clinical trial in terms of oncological relapse, clinical progression and improve the assistance and therapeutic strategy for each patient. retrospective data for patients who underwent surgery between 1987 and today will be available in the form of clinical report stored in the hospital archives.

Eligibility criteria:
inclusion criteria: * 18 years or older * upper tract urothelial cancer diagnosis * indication to cancer removal through nephroureterectomy surgery * ability to read and sign the informed consent exclusion criteria: * age \< 18 years * absence of upper tract urothelial cancer * inability to read and sign the informed consent

Keywords: upper urinary tract urothelial carcinoma nephroureterectomy surgery relapse quality of life diagnosis and treatment strategies
papillomavirus load in rheumatic inflammatory diseases

Conditions: Spondyloarthritis; Rhumatoid Arthisis

Summary: rheumatoid arthritis (ra) and spondyloarthritis (spa) are the two most common chronic inflammatory rheumatism, with a prevalence in the french population of 0.3% and 0.4%, according to the criteria european league against rheumatism / american college of rheumatology (eular / acr) 2010 and assessemnt of spondyloarthritis international society (asas) 2009 respectively. in patients whose pathology is resistant to first-line treatment, such as methotrexate for rheumatoid arthritis and peripheral spondyloarthritis, or non-steroidal anti-inflammatory drugs for axial spondyloarthritis, the treatment is based on biotherapies, such as anti-inflammatory drugs. -tnf, to obtain effective control of the disease and prevent joint damage. human papillomavirus (hpv) infection, the leading risk factor for cervical carcinoma, is the most common sexually transmitted infection (sti) with a particularly high prevalence among young women. in addition, anti-tnf, used in the treatment of ra and spa, and anti-il6 receptor, used in that of ra, could have opposite effects on hpv-dependent oncogenesis. thus, patients with ra or spa may have a higher risk than the general population of progression to cervical cytological abnormalities. evaluation of the chronic carriage of hpv would then be a useful tool in the management of these patients.


Eligibility criteria:
inclusion criteria: * woman between 18 and 65 years old * patient with rheumatoid arthritis as defined in 2010 acr/eular criteria or with spondyloarthritis as defined in 2009 asas criteria * patient able to understand the objectives of the study and give documented informed consent * patient affiliated to a social security scheme exclusion criteria: * pregnant or breastfeeding patient * patient with a history of cervical cancer * patient under juridical protection * patient unable to provide informed consent due to linguistic or psychic impairment

Keywords: hpv infection spondyloarthritis rhumatoid arthritis cervical smear cervical cancer screening
cns prophylaxis in diffuse large b-cell lymphoma

Conditions: Diffuse Large B-cell Lymphoma

Summary: comparison of cumulative incidence of cns relapses in patients with diffuse large b-cell lymphoma with intermediate or high risk of cns relapse treated with cns prophylaxis: either with 2 doses of intravenous methotrexate 3g/m2 i.v.(arm a) or 6 doses of intrathecal methotrexate 12mg (arm b) and in patients with low risk of cns relapse without cns prophylaxis (arm c).

patients with diffuse large b-cell lymphoma are evaluated for risk factors of cns relapse during initial staging (age \> 60years, lactate dehydrogenase (ldh) \> reference range, clinical stage iii/iv, performance status according to eastern cooperative oncology group (ecog) \>1, kidney and/or adrenal gland involvement, involvement \> 1 extranodal organ) including evaluation of cerebrospinal fluid. all patients with systemic dlbcl without cns involvement are treated with systemic chemotherapy: either 6 cycles of r chop (rituximab, cyclophosphamide, doxorubicin, vincristine, prednison) +2xr (rituximab) or 6 cycles of da epoch r (dose adjusted etoposide, prednison, vincristin, cyclophosphamide, doxorubicin) +2xr (rituximab). patients with ≥ 2 risk factors for cns relapse or with occult meningeal involvement will be randomized in 1:1 ratio either into arm a with 2 cycles of prophylactic methotrexate 3g/m2 i.v., or into arm b with prophylactic 6x intrathecal methotrexate 12mg (1x intrathecal methotrexate in each cycle of systemic chemotherapy). patients with 0-1 risk factor will be allocated into arm c without cns prophylaxis. patients will be observed for cns relapse during the follow-up of 1year after the end of the first-line treatment.

Eligibility criteria:
inclusion criteria: * histologically confirmed dlbcl * age 18-72 years * signed informed consent with the study * first-line treatment 6 cycles of r chop +2x r or 6 cycles of da epoch r+ 2xr exclusion criteria: * dlbcl and concomitant initial cns involvement * pmbl (primary mediastinal b-cell lymphoma) * treatment with another chemotherapy than r chop or da epoch r * hiv positive, or active hepatitis b or c * other concomitant serious disease (based on the decision of the physician-investigator) * non-compliance of a patient * any contraindication for application of anthracycline based chemotherapy or high dose methotrexate * pregnancy or breast-feeding

Keywords: lymphoma, b cell central nervous system relapse methotrexate intrathecal chemotherapy
descriptive study of trampoline accidents in the pediatric emergency department of rennes

Conditions: Trauma; Emergencies; Child, Only

Summary: the aim of this study is to compare trauma related to others sport to trauma due to trampoline in pediatric emergencies of rennes.

trampoline accidents are increasing since a few years. in rennes hospital, pediatric emergencies are experiencing a subjective increase in admissions for trampoline trauma with increasingly early ages and severe trauma. the aim of this study is to compare trauma related to others sport to trauma due to trampoline in pediatric emergencies of rennes. in parallel, retrospective data analysis will be performed on the same data during the year 2008, to compare with a period before the explosion of trampoline sales.

Eligibility criteria:
inclusion criteria: * child from 2 to 16 years old * childs admitted in emergencies unit for a trauma * parents not opposed in their child's participation to the study exclusion criteria: * child under 2 years old (before learning to walk) * single wounds and head injuries not related to sports activities (fall from a bed or from its height, simple wound with sharp objects)

Keywords: trampoline
online primary care physician (pcp) training in screening, brief intervention, referral, and treatment

Conditions: Medical Education

Summary: this project seeks to develop a comprehensive, computer-based education program for primary care physicians that will improve their skills in structured substance abuse screening, brief interventions, and referral and treatment (sbirt). the investigators will develop two online education programs based on virtual patient (vp) technology. one program will include five typical, interactive, problem-solving vps and the second will include five identical vps except that two vps will have been "worked" by substance abuse experts and presented as case studies. the remaining three vps will be "unworked" (typical vps). the investigators hypothesize that both education programs will significantly improve educational outcomes, compared to no training, as measured by a validated survey tool. a secondary hypothesis is that physicians using the "worked" (guided learning) program will achieve similar educational results as those using the typical vp approach, but will require less training time.


Eligibility criteria:
inclusion criteria: * physician in primary care training program * faculty member in primary care training program exclusion criteria: * advanced medical training in substance abuse management

Keywords: online education medical education substance abuse training drug abuse training
trial of nivolumab vs therapy of investigator's choice in recurrent or metastatic head and neck carcinoma (checkmate 141)

Conditions: Squamous Cell Carcinoma of the Head and Neck

Summary: the purpose of this study is to find out whether nivolumab will significantly improve overall survival as compared to therapy of investigator's choice in patients with recurrent or metastatic head and neck carcinoma.


Eligibility criteria:
for more information regarding bms clinical trial participation, please visit www.bmsstudyconnect.com inclusion criteria: * men and women ≥ 18 years of age with an eastern cooperative oncology group (ecog) performance status ≤ 1 * histologically confirmed recurrent or metastatic scchn (oral cavity, pharynx, larynx), stage iii/iv and not amenable to local therapy with curative intent (surgery or radiation therapy with or without chemotherapy) * tumor progression or recurrence within 6 months of last dose of platinum therapy in the adjuvant (ie with radiation after surgery), primary (ie, with radiation), recurrent, or metastatic setting * measurable disease by computed tomography (ct) or magnetic resonance imaging (mri) per response evaluation criteria in solid tumors (recist 1.1) criteria exclusion criteria: * active brain metastases or leptomeningeal metastases are not allowed * histologically confirmed recurrent or metastatic carcinoma of the nasopharynx, squamous cell carcinoma of unknown primary, and salivary gland or non-squamous histologies (eg: mucosal melanoma) are not allowed * subjects with active, known or suspected autoimmune disease
omidria and dexycu, or omidria and dextenza compared to topical prednisolone acetate 1% following cataract surgery

Conditions: Cataract Surgery

Summary: this research will evaluate the efficacy of omidria and dexycu, omidria and dextenza, and omidria and prednisolone acetate 1% in the resolution of post-operative inflammation and pain following cataract surgery.

prospective, randomized trial where patients will be randomly assigned to 1 of 3 groups, each with a sample size of 25 (total n=75). group 1 will receive dexycu + omidria (omidria = ketorolac + phenylephrine), group 2 will receive dextenza + omidria, and group 3 will receive prednisolone acetate + omidria. each of the drug combinations used in each of the 3 groups is standard of care, fda approved, and will be used on label. 1:1:1, n=75 with 25 subjects assigned to each of the 3 groups.

Eligibility criteria:
inclusion criteria: * patients 18 years of age or older, undergoing routine, uncomplicated cataract surgery. exclusion criteria: * any history of corneal dystrophy, corneal surgery within 6 months of cataract surgery, previous intraocular surgery, any concomitant eye drop use besides artificial tears, previous ocular trauma, or a history of treated glaucoma. no additional procedures can be done at the time of cataract surgery (e.g., stent placement, endo-laser, etc.), but femto-second laser-assisted surgery is permitted.

Keywords: dextenza intracanalicular dexamethasone dexamethasone ophthalmic insert dexycu omidria
investigation of how pd 0332334 and metformin are eliminated from the body when they are administered at the same time

Conditions: Generalized Anxiety Disorder

Summary: 1. to estimate the effects of multiple doses of pd 0332334 on the elimination of a single dose of metformin from the body 2. to estimate the effects of multiple doses of metformin on the elimination of a single dose of pd 0332334 from the body 3. to evaluate the safety and tolerability when pd 0332334 and metformin are administered at the same time.

detailed description: additional study purpose details: to assess the pharmacokinetics of metformin and pd 0332334 with concurrent administration. on february 18th 2009, a decision to terminate further development for pd 0332334 was communicated to investigators in this study. the decision to terminate this study was not based on any safety concerns.

Eligibility criteria:
inclusion criteria: * nonsmokers * male or female adults exclusion criteria: * current or history of significant medical illness * smokers * illicit drug use

Keywords: metformin, pd 0332334, organic cation transporter, oct2, pharmacokinetics
folcrom trial: foley catheter in rupture of membranes

Conditions: Premature Rupture of Membranes

Summary: multicenter randomized clinical trial comparing oxytocin versus oxytocin and foley catheter for induction in women who present with premature rupture of membranes who are not in labor.

this is a prospective, randomized, multi-center clinical trial to test the hypothesis that in women with term and near term premature rupture of membranes (prom), an intrauterine foley catheter plus oxytocin infusion will decrease the mean time from induction to delivery by 2.5 hours as compared to oxytocin alone.

Eligibility criteria:
inclusion criteria: 1. spontaneous rupture of membranes (rom) ≥1 hour prior to starting induction; rom defined as clinical history with the presence of 2 of the following 4: pooling, ferning, nitrazine, oligohydramnios. in the absence of clinical history, oligohydramnios and pooling must be present for rom to be diagnosed. oligohydramnios is defined as a total amniotic fluid index of \<5cm or a maximum vertical pocket \<2cm. 2. unfavorable cervix, defined as sterile digital exam ≤ 2cm dilated / 80% effaced 3. gestational age ≥ 34 weeks by best obstetric estimate 4. clinical management decision is vaginal delivery 5. singleton gestation 6. cephalic presentation 7. willing to participate and able to understand and sign the informed consent document before randomization 8. women of reproductive age exclusion criteria: 1. multiple gestations 2. lethal fetal anomalies, e.g., anencephaly, trisomy 13, trisomy 18 3. latex allergy 4. greater than 1 prior cesarean delivery 5. active labor - defined as contractions more frequent than every 5 minutes (or ≥ 12 contractions in 1 hour) associated with ≥ 1 cm cervical change. in the absence of ≥ 1 cm cervical change after 2 hours, patients with contractions can be included in the study. 6. suspicion of chorioamnionitis 7. any contraindications to vaginal delivery, including malpresentation, active herpes, complete placenta previa, greater than two prior cesarean deliveries, etc. 8. hiv positive status or aids 9. intrauterine fetal demise 10. suspected placental abruption, significant hemorrhage 11. nonreassuring fetal heart rate (fhr) pattern 12. participation in a competing trial

Keywords: foley catheter foley bulb oxytocin
study to evaluate the efficacy and safety of the combination of valturna and amlodipine or valturna and chlorthalidone versus valturna alone in patients with stage 2 hypertension and diabetes

Conditions: Hypertension; Stage 2 Hypertension; Diabetes

Summary: this was a study to assess the safety and efficacy of valturna and amlodipine or valturna and chlorthalidone when compared to valturna alone in patients with stage 2 hypertension and diabetes mellitus 2.


Eligibility criteria:
inclusion criteria: * patients with stage 2 hypertension within protocol limits at randomization * patients with type 2 diabetes mellitus with hga1c less than or equal to 9% * patients with newly diagnosed hypertension or patients who have not received antihypertensive therapy for at least 4 weeks prior to screening exclusion criteria: * patients taking 4 or more antihypertensive medications at screening visit * patients with uncontrolled bp (\> 140/90 mmhg) while taking 3 or more antihypertensives at their maximum approved doses * type 2 diabetes mellitus requiring insulin treatment * patients with hga1c \> 9% * patients with known gout * known history of cancer within the past 5 years * patients who are pregnant or nursing mothers * patients who have participated in an investigational clinical trial within the 30 days prior to screening. * other protocol-defined inclusion/exclusion criteria may apply

Keywords: high blood pressure diabetes
cassava intervention project

Conditions: Neurotoxicity Syndrome, Cassava; Neurotoxicity Syndrome, Cyanate; Neurotoxicity Syndrome, Cyanide; Neurotoxicity Syndrome, Thiocyanate

Summary: investigators will implement a novel cassava processing method (wetting method, wtm) that safely removes cyanogenic compounds from cassava flour prior to human consumption in a stratified village-cluster randomized non-inferiority trial so as to compare the effectiveness of a peer-led intervention (women training other women in the wtm) with that by community-health worker specialists.

the proposed project seeks methods to prevent and elucidate biomarkers of neurocognition and motor deficits associated with chronic dietary reliance on cyanogenic cassava, a staple food crop for more than 600 millions of people living in the tropics. aim 1 will implement a novel cassava processing method (wetting method, wtm) that safely removes cyanogenic compounds from cassava flour prior to human consumption in a stratified village-cluster randomized non-inferiority trial so as to compare the effectiveness of a peer-led intervention (women training other women in the wtm) with that by community-health worker specialists (2 intervention training arms). aim 2 will determine whether post-intervention reductions in cassava cyanogenic content and child u-scn are associated with changes in biomarkers of cassava neurotoxicity particularly 8,12-iso-ipf2α-vi isoprostane (oxidant marker), carbamoylated albumin fragments kvpqvstptlvevsr (residues 438-452) and ldelrdegkassak (residues 206-219), or homocitrulline (carbamoylating markers), and scores at the kabc-ii cognition and bot-2 motor testing.

Eligibility criteria:
inclusion criteria: * households with a konzo child and non-konzo sibling between 5 and 12 years * presence of a biological mother primarily responsible for the household food preparation and caring for the children * mother consenting to participate in this study exclusion criteria: * history of seizures * history of cerebral malaria * history of retroviral (hiv-htlv) infections

Keywords: cassava konzo cyanide cyanate thiocyanate carbamoylation isoprostanes oxidative damage
improvement of insulin resistance with traditional chinese treatment in patients with type 2 diabetes

Conditions: Type 2 Diabetes

Summary: the purpose of this study is to evaluate the efficacy of traditional chinese treatment(tct) on insulin sensitivity and other related factors in type 2 diabetes by using an double-blind, randomized, parallel control and prospective study this traditional compound chinese herb preparation is referred to this study, with three kinds of plants: 50 mg of coptis chinensis, 30 mg of astragalus mambranesceus and 120 mg of lonicera japonica, all of which are selected by the chinese academy of medical sciences among those traditionally considered effective and safe in the treatment of diabetes. patients enrolled were randomized into tct group and placebo group administrated with tct and placebo respectively. glucose disposal rate (gdr), fasting plasma glucose (fpg), postprandial plasma glucose (ppg), hba1c and other metabolic components were assessed at baseline and end point


Eligibility criteria:
inclusion criteria: 1. newly diagnosed type 2 diabetes poorly controlled by diet only for one month 2. obese with a bmi of 23-35 kg/m2 exclusion criteria: 1. those patients used any drugs for treatment of diabetes 2. patients with evidence of cardiac, hepatic, renal, other chronic diseases or acute diabetic complications including diabetic ketoacidosis or hyperosmolar hyperglycemic non-ketotic coma 3. women who were pregnant or planned pregnant.

Keywords: traditional chinese treatment
elbow hemiarthroplasty versus total elbow arthroplasty for irreparable distal humeral fractures

Conditions: Distal Humerus Fracture

Summary: distal humeral fractures can be difficult to treat, in particular when the joint surface is affected (intra-articular fractures). if rigid internal fixation with plates and screws can be obtained it is considered to be the treatment of choice. in elderly patients, poor bone quality (osteopenia) and fragmentation of the articular surface can make rigid internal fixation non-reliable or even impossible. total elbow arthroplasty has been shown to be of value in this type of situation. elbow hemiarthroplasty has been proposed as an alternative to total elbow arthroplasty. the theoretical advantages as opposed to total elbow arthroplasty are: no restriction in the weight allowed to be lifted, complications related to polyethylene wear debris are avoided as there is no polyethylene liner and there is no ulna component that can loosen. wear of the native ulna and instability are potential complications of elbow hemiarthroplasty. the aim of this multicenter study is to test the hypothesis that elbow hemiarthroplasty gives better elbow function than total elbow arthroplasty for irreparable distal humeral fractures.


Eligibility criteria:
inclusion criteria * intra-articular distal humeral fracture with two or more displaced joint surface fragments devoid of soft tissue attachment * osteopenia * fracture deemed unsuitable for internal fixation * low-energy trauma * closed fracture * independent living exclusion criteria * comorbidity that affects elbow rehabilitation considerably * severe pre-existing elbow disease * concurrent injury that affects elbow rehabilitation considerably * pathologic fracture * vascular injury * inability to participate in follow-up

Keywords: distal humerus fracture arthroplasty, replacement, elbow