Kornimate/medical-research-clean huggingface dataset:
fecal microbiota transplantation for pancreatitis

Conditions: Acute Pancreatitis; Intestinal Bacteria Flora Disturbance; Intestinal Dysfunction; Fecal Microbiota Transplantation

Summary: the intestinal microbiota plays a pivotal role in the maintenance of intestinal homeostasis and protecting the gut against pathogens by competing for nutrients, creating the intestinal biological barrier and modulating the host immune system.after the onset of acute pancreatitis,the intestinal hypoperfusion and the release of inflammatory mediators result in intestinal barrier dysfunction and intestinal bacteria dysbiosis.this leads to bacterial and endotoxin translocation, which may cause infectious complications which are major causes of death in sap patients.recently,fmt was shown its efficacy in the treatment of gastrointestinal(gi) diseases and non-gi disorders associated with intestinal flora disturbance by re-establishing the damaged intestinal bacteria homeostasis.however,the mechanism by which fmt results in cure of diseases has been poorly understood.this study aims to investigate the therapeutic potential of fmt for sap patients with intestinal barrier dysfunction.

investigators aims to restore the intestinal bacteria homeostasis through fmt by retention enema with fresh bacteria,thus stabilizing intestinal barrier dysfunction,minimizing bacterial translocation and preventing infectious complications.the investigators will further examine the effect of fmt on inflammatory markers，the predictors of intestinal barrier injury and the incidence of infectious complications.

Eligibility criteria:
inclusion criteria: 1. diagnosis of acute pancreatitis from the first affiliated hospital of nanchang university according to the classification of acute pancreatitis-2012: revision of the atlanta classification and definitions by international consensus 2. onset of pancreatitis within \<=2 weeks 3. complicated with gastrointestinal failure. gastrointestinal failure was defined if the patients were complicated with obvious abdominal distention, abdominal rumbling sound weakening or disappearance, no self-defecation as well as intra-abdominal hypertension. exclusion criteria: 1. sap complicated by gastrointestinal bleeding or intestinal fistula 2. pregnancy and lactation women 3. not signed the informed consent 4. diabetes and autoimmune diseases 5. multiple organ failure. organ failure was defined as a score of 2 or more using the modified marshall scoring system including respiratory failure, renal failure and circulatory.

Keywords: severe acute pancreatitis fecal microbiota transplantation intestinal barrier dysfunction intestinal flora
mast cells and its proteases in copd

Conditions: COPD Exacerbation

Summary: mast cells proteases such as chymase and tryptase will be studied in the tissue of small and large airways in copd patients


Eligibility criteria:
inclusion criteria: - copd patients exclusion criteria: other lung diseases, tumors, pregnancy -

Keywords: mast cell tryptase chymase copd
study for safety and efficiency of therapeutic angiogenesis for patients with limb ischemia by transplantation of human cord blood mononuclear cell

Conditions: Ischemia

Summary: the purpose of this study is to analyze the safety and efficiency of therapeutic angiogenesis for patients with limb ischemia by transplantation of human cord blood mononuclear cells.


Eligibility criteria:
inclusion criteria:patients with ischemic symptoms such as claudication, rest pain or nonhealing ischemic wound * without evidence of improvement in response to conventional medical therapy * not candidates for surgical intervention or radiologic intervention exclusion criteria: * malignant disease * more than 60 years old * other significant medical conditions, including diabetes mellitus, hypertension, hyperlipidemia, etc.

Keywords: safety and efficiency of angiogenesis for patients with limb ischemia by transplantation of human cord blood mononuclear cells
transcranial direct current stimulation therapy for major depression

Conditions: Major Depressive Disorder

Summary: depression is a prevalent and debilitating disorder. the most common treatments are antidepressant medications and talking therapies. however, for many individuals, these are not their treatment of choice. furthermore, even following a full course of treatment with an antidepressant or talking therapy, over one third of patients continue to be unwell. the novel brain stimulation treatment, transcranial direct current stimulation (tdcs), is a potential first-line treatment for major depression. the present research question is whether tdcs can be provided as a home-based treatment for major depression for adults with major depression.

the novel brain stimulation treatment, transcranial direct current stimulation (tdcs), is a potential first-line treatment for major depression. tdcs generates a small electric current which modulates how easy it is for active brain cells to discharge. the device is a neoprene cap worn over the head, and in the cap there are two electrodes, which are small metal discs, where the current comes from. tdcs does not directly stimulate brain cells to cause a seizure like electroconvulsive therapy (ect) and it does not induce brain cells to discharge like transcranial magnetic stimulation (tms). clinical studies have shown that tdcs treatment could help to improve the symptoms of depression. the main side effects have been redness, skin irritation or sensations (itching, tingling or burning) under the electrodes. less commonly reported side effects include headache or tiredness. tdcs is a portable and safe treatment. the studies to date have mostly looked at tdcs treatment which has been provided in a research setting. this is a problem because the treatment requires daily sessions for several weeks which could limit whether individuals would be able to go every day. as tdcs is a portable and safe treatment, it could be provided in the community. the study research question is whether tdcs could be provided as a home-based treatment for major depression. the study will include adults with major depression.

Eligibility criteria:
inclusion criteria: * diagnosis of major depressive disorder based on dsm-5 criteria * minimum score of 16 on hamilton rating scale for depression (ham-d) exclusion criteria: * history of treatment-resistant depression * comorbid psychiatric disorder * significant risk of suicide or self harm * any contraindications to tdcs, including implanted electronic medical devices
clinical and molecular characterization of cerebral proliferative vasculopathy

Conditions: Proliferative Vasculopathy

Summary: as principal objective, the study aims to: 1. describe the spectrum and evaluate the frequency of angiodysplasia of the nevrax; 2. establish the physiopathological basis of fowler's syndrome; 3. identify flvcr2 partners and the signaling pathways involved; 4. test new candidate genes: gpr124 and possible partners of flvcr2. as second objective, the study aims to: * perform phenotype / genotype correlation if necessary; * and propose a prenatal diagnosis in families with identified mutations.


Eligibility criteria:
inclusion criteria: * angiodysplasia restricted to central nervous system with or without glomerular vasculopathy. * informed consent signed. exclusion criteria: * vascular malformations not confined to the nevrax. * no signature of consent.

Keywords: fowler syndrome
the effects of sufentanil vs. remifentanil in total intravenous anesthesia with remimazolam on postoperative pain

Conditions: Stomach Neoplasms

Summary: in this study, the investigators evaluate the effect of total intravenous anesthesia using sufentanil-remimazolam and remifentanil-remimazolam on postoperative pain in patients undergoing laparoscopic gastrectomy.


Eligibility criteria:
inclusion criteria: 1. 20years or older 2. scheduled for laparoscopic-assisted gastrectomy 3. american society of anesthesiologists(asa) physical status i and iii exclusion criteria: 1. emergency operation 2. patients with a history of severe hypersensitivity reaction to dextran 40 3. patients who cannot use patient controlled analgesia(pca) 4. patients with morbid obesity \[body mass index (bmi) \>35 kg/m2\] 5. patients with history of uncontrolled hypertension (diastolic bp \>110mmhg) or dm 6. patients with history of heart failure (unstable angina, congestive heart failure) 7. patients with history of liver failure, renal failure, allergic to medicine 8. patients with history of cerebrovascular disease (cerebral hemorrhage, cerebral ischemia) 9. patients with history of uncontrolled psychiatric disease (ptsd, anxiety, depression) 10. patients with obstructive sleep apnea 11. patients who cannot read the consent form (examples: illiterate, foreigner) 12. patients who withdraw the consent
mechanisms of hypertension in women with polycystic ovary syndrome

Conditions: Polycystic Ovary Syndrome; Hypertension

Summary: women with androgen excess polycystic ovary syndrome (ae-pcos) leads to hypertension.

our scientific premise is that in ae-pcos women, the androgen-dominant hormonal milieu causes bp increases via sympathetic activation, vasoconstriction and renal sympathetic nervous system activation. moreover, this androgen-dominant milieu increases bp via activation of the renin-angiotensin system.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of polycystic ovary syndrome * able to inject study drug * able to swallow pills controls: -diagnosis of insulin resistance exclusion criteria: * any woman that does not fit the inclusion criteria * males
usability study of ontrack tools

Conditions: Research With Clinical Staff in Stroke Rehabilitation

Summary: aims: assess the usability of ontrack tools, a clinician facing interface to manage stroke survivors using the ontrack rehabilitation system. background: arm disability is a common problem after stroke that can lead to loss of independence, it affects \~450,000 people in the uk. repetitive activity is critical for recovery but research shows people can struggle with intensity and keeping track of progress. the ontrack system being developed at imperial college london is a potential solution to this problem. intervention: the ontrack system consists of two software applications, ontrack app - used by patients, and ontrack tools - used by clinicians. ontrack tools pulls data generated by the ontrack app and enables the monitoring of clients' arm activity, and management of goals and educational content. the software is used to inform selfmanagement coaching by helping therapists understand more about how and when patients use their affected arm between treatment sessions. design and methods: this study will assess the usability of the ontrack tools component of the system. the study will recruit stroke therapists from imperial college healthcare nhs trust to provide feedback on the experience and usability of ontrack tools' graphical user interface (gui). the study will be divided into three progressive cycles of testing, feedback and iteration. each cycle will see participants individually completing specific tasks related to system navigation and the management of patients under simulation. participants will complete outcome measures and take part in focus groups. researchers will analyse and use the feedback to improve the gui ready for the next testing cycle. patient and public involvement: the project team includes a ppie group of stroke survivors who oversee the project and help us with public facing documentation. they are members of the research team and are reimbursed for their time and travel, according to involve guidance. dissemination: results of the study will be written-up for technical reporting and publication. participants will be provided with a summary of results at the end of the study. the study team will be providing general updates on the progress of the study via their social media channels (e.g. twitter @ontrackrehab @imperialighi @helixcentre).


Eligibility criteria:
inclusion criteria: * adult (18 years old or over) occupational therapists and physiotherapists (band 4 to band 8) working in the stroke wards at icht. exclusion criteria: * no exclusion criteria has been defined.

Keywords: stroke, rehabilitation, neurology, digital health
parental perceptions and acceptance of silver diamine fluoride in italy

Conditions: Perceptions; Acceptability; SDF

Summary: parental perceptions on staining due to silver diamine fluoride (sdf) could affect its implementation in pediatric dentistry. this study represents the second part of a wider project focused on sdf aesthetic acceptability among italian parents.

the aim of this survey was to assess the parental acceptance of silver diamine fluoride (sdf) staining in italy, and to examine wether the level of acceptability depends on location, child's behavior, or demographic background. a cross-sectional study was undertaken, involving 234 italian parents whose children were attending two university dental clinics. using a validated italian version of the questionnaire 'parental perceptions of silver diamine fluoride dental color changes', researchers administered a series of closed-ended likert-type questions to parents. the questionnaire included sets of colored photographs showing both anterior and posterior teeth before and after sdf treatment. respondents were requested to provide their assessments based on the presented visual stimuli.

Eligibility criteria:
inclusion criteria: * italian-speaking parents * parents of healthy children or children with mild systemic disease. american society of anesthesiologists (asa) status 1-2 * parents of children under the age of 12 years * parents of children with previous caries experience in primary teeth * parents who consented to participate exclusion criteria: * no italian-speaking parents * parents of children with asa status ≥ 3 * parents of children over the age of 12 years * parents of children without previous caries experience in primary teeth * parents who no consented to participate

Keywords: silver diamine fluoride parental perceptions and acceptance
prognostic value of a multidimensional assessment for survival in elderly patients with ckd 4b/5

Conditions: Chronic Kidney Disease Stage 5; Chronic Kidney Disease Stage 4B

Summary: the aim of this study is to determine a multidimensional signature (integrating frailty and patient-reported outcomes measures (proms) at entry into stage 4b/5 ckd) to improve prediction of renal death (dialysis, transplantation, conservative management, death).

in 2019, 4,263 patients starting dialysis in france were aged 75 years or older. this elderly population, often with comorbidities, poses a number of challenges for nephrologists, both in terms of initiation and modalities of dialysis and access to transplantation. dialysis may offer little benefit in terms of survival, often at the cost of a significant impact on quality of life and number of hospitalisations. there is a current trend to offer conservative treatment as an alternative to dialysis. however, there are no objective criteria to guide this decision and the uremic syndrome may distort certain clinical perceptions. the aim of this study is to determine whether an assessment that incorporates multiple dimensions, including those of frailty, can help the clinician determine the best course of treatment for the patient.

Eligibility criteria:
inclusion criteria: * patients with ckd stage 4b or 5 (first consultation with gfr \< 20 ml/min /1.73 m2 in ckd-epi 2009). * fluency in french * membership of a french social security scheme * non-opposition from the subject to participate in the study exclusion criteria: * subjects with limited legal capacity. * subjects still in the exclusion period of another study, or according to the national registry of clinical trial participants. * subjects with no social security coverage. * subjects judged by the investigator to be unlikely to comply with study procedures * subjects unable to understand the reasons for the study; psychiatric disorders judged by the investigator to be incompatible with inclusion in the study.

Keywords: frailty patient-related outcomes personalised care
evaluation of adjuvant use in selective trunk block

Conditions: Analgesia; Nerve Blocks; Postoperative Pain, Acute

Summary: "evaluation of the anesthetic and analgesic efficacy of dexamethasone in selective trunk blocks

the investigators hypothesize that the perineural application of dexamethasone as an adjuvant in selective trunk block for upper extremity surgeries will accelerate the onset time of anesthesia and analgesia, provide significant anesthetic and analgesic effects, and prolong the duration of anesthesia and analgesia. in recent years, the brachial plexus block, performed with various approaches, has been preferred over general anesthesia for upper extremity orthopedic surgeries due to its numerous advantages. it maintains the patient's consciousness and spontaneous respiration, reduces airway interventions, provides effective postoperative pain control, minimizes opioid-related side effects, limits surgery-related metabolic and endocrine changes, enables early discharge, and reduces treatment costs. selective trunk block offers rapid block onset and high success rates. the use of ultrasound in peripheral blocks has also reduced the risk of various complications (e.g., vascular injury). the selective trunk approach, as described by manoj kumar karmakar in 2020, involves blocking the upper, middle, and lower trunks at the c7 transverse process level, resulting in sensory/motor block in all ipsilateral upper extremity dermatomes except t2. this study aims to compare the anesthetic and analgesic efficacy of dexamethasone as an adjuvant to bupivacaine in the selective trunk block approach. dexamethasone is a widely used glucocorticoid with anti-inflammatory, anti-toxic, and other effects. it has strong lipophilic properties, is soluble in fat, increases ph, facilitates the penetration of local anesthetics into nerve sheaths, and extends the duration of local anesthetic effects, as supported by various studies. additionally, dexamethasone is commonly used in pain management for its neuromodulatory effects.

Eligibility criteria:
inclusion criteria: * patients undergoing upper extremity surgery with asa (american society of anesthesiologists) classification i-ii * aged 18-65 years, and with a body mass index (bmi) between 18-35 kg/m² were included in the study. exclusion criteria: * included asa iii-iv patients * those who refuse the block * pregnant and breastfeeding women * individuals with severe lung disease * contralateral diaphragm paralysis * nerve injury secondary to trauma * neuromuscular diseases, * peripheral neuropathy * bleeding diathesis * history of anticoagulant use * allergies to local anesthetics or dexamethasone * uncontrolled diabetes mellitus * morbid obesity with bmi \>35 kg/m² * severe cardiovascular, renal, or liver disease, and infections at the site where the nerve block is to be applied.

Keywords: postoperative pain postoperative analgesia selective trunks block
developing and testing a model to identify preventive vision loss among older patients in general practice

Conditions: Vision Impairment and Blindness; Glaucoma; Age-Related Macular Degeneration; Cataract; Diabetic Retinopathy

Summary: in this cohort study, the investigators will test vision screenings in danish general practice for patients over 70 years of age with minimum one chronic condition. the main outcome is detection of vision impairment and secondary outcome is detection of conditions needing ophthalmologic follow-up but not presenting vision impairment at present time.

introduction: the number of people living with visual impairment is increasing. visual impairment causes loss in quality of life and reduce self-care abilities. the burden of disease is heavy for people experiencing visual impairment and their relatives. the severity and progression of age-related eye diseases are dependent on the time of detection and treatment options, making timely access to healthcare critical in reducing visual impairment. general practice plays a key role in public health by managing preventive healthcare, diagnostics and treatment of chronic conditions. general practitioners (gps) coordinate services from other healthcare professionals. more involvement of the primary sector could potentially be valuable in detecting visual impairment. methods: investigators apply the medical research council framework for complex interventions to develop a primary care intervention with the gp as a key actor, aimed at identifying and coordinating care for patients with low vision. the development process will engage patients, relatives and relevant health professional stakeholders. the investigators will pilot test the feasibility of the intervention in a real-world general practice setting. the intervention model will be developed through a participatory approach using qualitative and creative methods such as graphical facilitation. the project aims to explore the potentials and limitations of general practice in relation to detection of preventable vision loss. ethics and dissemination: ethics approval is obtained from local authority and the study meets the requirements from the declaration of helsinki. dissemination is undertaken through research papers and to the broader public through podcasts and patient organisations.

Eligibility criteria:
inclusion criteria: * +70 years * one or more chronic diseases * are followed by gp du to chronic disease exclusion criteria: * dementia diagnosis * known eye-diseases or are currently followed by private ophtalmologist * not able to understand danish