Kornimate/medical-research-clean huggingface dataset:
modulating movement intention via cortical stimulation

Conditions: Seizures; Seizure Disorder; Psychogenic Movement Disorder

Summary: the purpose of this protocol is to learn about movement intention and volition. to improve such knowledge, investigators will conduct sub-studies using multiple non-invasive methodologies. these results could provide preliminary data for subsequent studies evaluating local and global efficacy of plasticity-inducing treatments for pmd symptoms.

this study will: * explore effects of tms and tdcs on movement intention. * discern the neural activity underlying modulation of movement intention with neuroimaging recording. * identify brain stimulation's effect in patients with psychogenic tremor and non-epileptic seizures. * technical development of new experimental paradigms and data analysis methods. * data collection for hypotheses development.

Eligibility criteria:
inclusion criteria: (healthy controls) * fluent in english (patients with pmd or pnes): * diagnosis of pmd/pnes confirmed by a neurologist with expertise in movement disorders. * per the treating neurologist, subject is unlikely to require treatment and/or dosage changes for 3-6 months following screening exclusion criteria: * any history of a significant neurological disorder, which may interfere with the interpretation of study data, as determined by the pi * chronic or progressive medical condition * any history of traumatic brain injury or significant head trauma * currently meets criteria for substance abuse or dependence * history of any psychotic disorder or other psychiatric condition which may interfere with data interpretation * pregnancy * metal or devices in the head, including neurostimulators or metal foreign bodies * any other implanted metal device, including pacemaker, spinal cord stimulator, vns. * any other ferromagnetic substance in the body that may increase study risk (including dental prosthetics, etc.). * taking tricyclic antidepressant or antiepileptic medications or cns active drugs under "strong potential hazard" list in rossi et al., 2009 * current diagnosis of any inflammatory or autoimmune disorder within last 6 months pmd and pnes patients * any history of traumatic brain injury or significant head trauma * diagnosis of organic seizure disorder, including febrile seizures and tonic-clonic seizures; * neurological disorder other than pmd and pnes including stroke, fainting spells or syncope of unknown cause(s); * major or unstable medical illness, especially any current diagnosis of inflammatory or autoimmune disorders within last 6 months * metal or devices in the head, including neurostimulators or metal foreign bodies * taking tricyclic antidepressant medications or cns active drugs under "strong potential hazard" list in rossi et al., 2009; * diagnosis of dementia, or montreal cognitive assessment (moca) ≤24; * recurrent visual hallucinations, within the past 6 months; * history of significant uncontrollable movements of the head; * any clinically significant abnormality on vital signs

Keywords: electroencephalography magnetoencephalography transcranial magnetic stimulation
back pain - linking phenotype to pain mechanism and outcome.

Conditions: Low Back Pain

Summary: to investigate whether different clinical, psychophysical and neurophysiological phenotypes can be identified among low back pain patients

low back pain patients will fill in a detailed questionnaire (incl. pain drawing) about their pain. some of them will undergo a standardized quantitative sensory testing protocol and an fmri procedure.

Eligibility criteria:
inclusion criteria: -primary complaint: low back pain clinically not attributable to red flags exclusion criteria: * any major medical or psychiatric condition that affects pain sensitivity * contraindications to mri

Keywords: low back pain, phenotype
mygenemydiet trial for weight management

Conditions: Overweight and Obesity

Summary: the study aims to determine if genotype-based nutrition and lifestyle advice is effective for the management of overweight and obesity among filipino adults compared to the usual standard of care.

the primary objective of the study is to determine if providing a nutrition and lifestyle advice with genetic information can promote the attainment of 5-10% weight loss, and improvements on body mass index, waist circumference, and body fat percentage among filipino adults with overweight and obesity. additionally, changes in dietary intake, eating behaviour, physical activity level, biochemical parameters (hba1c and blood lipid profile), motivation for weight loss, and knowledge and perceptions on nutrigenomics and genetic testing will also be assessed.

Eligibility criteria:
inclusion criteria: * overweight or obese filipino adults who signify a willingness to participate in the study * with bmi equal to 25.0 but not more than 40 kg/m2 * apparently healthy (fasting blood glucose, lipid profile, and blood pressure within the normal range to pre-disease state) * normal thyroid hormone levels in the blood * normal blood cortisol level * carriers of at least one of the risk alleles of fto rs9939609, ucp1 rs1800592, and tcf7l2 rs7903146 exclusion criteria: * elevated levels of fasting blood glucose, blood lipids, and blood pressure * elevated levels of thyroid hormones, and cortisol level * self-reported/history of heart disease * participation in a weight loss program or adherence to restrictive /therapeutic diet in the past 3 month * self-reported of recent weight changes greater or less than 3.0 kg * planned or recent bariatric surgery * consumption of weight-altering medications and/or nutritional supplements that promote weight gain/loss in the past 6 months * clinical diagnosis of any mental disorder and current use of any mental health medications * pregnant, nursing, or with self-declared intention to become pregnant * any health condition that may put the participant at risk * current and anticipated enrolment in another research study during the course of the trial

Keywords: overweight obesity nutritional genomics nutrigenomics dna-based nutrition advice genotype-based nutrition advice
survey on practice and comparison with best evidence in surgical site infection prevention in colorectal surgery

Conditions: Colorectal Surgery; Surgical Site Infection

Summary: web-based survey to colorectal surgeons assessing knowledge, beliefs and practices regarding the use of preventative measures for ssi.

a web-based survey (surveymonkey©; https://es.surveymonkey.com/r/fbvr59c) to the members of the colorectal chapter of the spanish association of surgeons (aec) and the spanish association of coloproctology (aecp). a link to the web page containing the survey is disseminated via email, newsletter and twitter. a board from the surgical infection section did a review of evidence and previous guidelines to be used in the evaluation of the results. the most recent clinical practice guidelines have been analysed. furthermore, an extensive review of specific measures for colorectal surgery has been published and used for evaluation. according to the review, the preventive measures analysed in the survey have been distributed into two groups: high or low level of evidence. the survey aim to assess knowledge, beliefs, and practices of attending colorectal surgeons on preventative measures including mechanical bowel preparation (mbp), oral antibiotic prophylaxis and the use of drains. furthermore, the questions address the level of accordance between their beliefs and the protocols or the usual practice of their units. the agreement rate between the beliefs and usual practice of all respondents will be calculated on a scale from 0 to 100. for discussion, the responses on the implementation of major surgical site infection (ssi) prevention measures will be compared with the recommendations of the expert group. other questions are related to the types of complications that surgeons believe are prevented by the use of oral antibiotic prophylaxis or mbp, reasons for not using either of them, type of oral and systemic antibiotics and cathartics used, and strategies already in place or that should be implemented to reduce ssi rates at respondents' hospitals. the results will be expressed in percentages on the total answers obtained. responses will be entered into a computerized database that will be analysed using the spss program (v.10.0, chicago, il, usa). the results will be analysed using the chi-square test with statistical significance defined as p \<0.05.

Eligibility criteria:
inclusion criteria: * colorectal surgeons members of the colorectal chapter of the spanish association of surgeons (aec) and the spanish association of coloproctology (aecp) exclusion criteria: * none

Keywords: surgical site infection prevention survey colorectal surgery guidelines
wound healing in primary tka

Conditions: Total Knee Replacement; Wound Complication

Summary: wound complications after total knee arthroplasty (tka) can arise from many patient-specific factors, such as vascular or immune-related medical conditions, obesity, and smoking, among others. the development of early wound complications can lead to increased length of hospital stay and more serious complications, including deep infection and major subsequent surgery. however, there are modifiable variables that could affect the risk of getting wound complications, such as the closure technique. this study aims to analyze the difference in rates of wound complications using two different closure techniques in primary tka.


Eligibility criteria:
inclusion criteria: * patients older than 18 years old that will undergo primary tka with a midline approach exclusion criteria: * previous knee arthroplasty surgeries or midline scars * tka secondary to oncologic or traumatic etiologies * bmi ≥ 40 * uncontrolled diabetes (measured by a hgb a1c above 8) * reported allergy to skin adhesive * immunodeficiencies * bleeding disorders * anticoagulation other than asa
diaphragmatic doming vs breathing exercises on ventilatory function & core endurance in chronic neck pain

Conditions: Neck Pain

Summary: the purpose of the study is to investigate if there is any difference between effect of diaphragmatic doming versus breathing exercises on ventilatory function and core endurance in patients with chronic neck pain

patients with chronic neck pain will be participated in this comparative study. they will be divided into 2 groups: group (a) will be consisted of 30 patients who will receive conventional physiotherapy treatment for chronic neck pain plus breathing exercise (diaphragmatic and pursed lip breathing) (three sessions per week for 6 weeks) group (b) will be consisted of 30 patients who will receive conventional physiotherapy treatment for chronic neck pain plus doming of the diaphragm (three sessions per week for 6 weeks) pulmonary functions and neck endurance will be assessed for all patients in both groups before the first session and after the last session

Eligibility criteria:
inclusion criteria: * patient has chronic neck pain (for more than 3 months) * their age ranged from 20 to 30 years old * their body mass index ranged from (18.5 -29.9) kg/m2 * poor results on the cranio-cervical flexion (ccf) test using a pressure biofeedback instrument. exclusion criteria: * history of respiratory disease and clinical signs of a severe cardiac event. * severe psychiatric or cognitive impairment * tumor and spinal fractures * spinal cord compression that required urgent surgery * current or past smokers * obese (bmi \>30) or underweight (bmi ˂18.5)

Keywords: chronic neck pain
vitamin c as an adjunct in periodontal treatment in type 2 diabetes mellitus patients

Conditions: Diabetes Mellitus Type 2 With Hyperglycemia; Periodontitis

Summary: periodontitis patients with uncontrolled type 2 diabetes mellitus will receive non-surgical periodontal treatment and then be supplemented with daily 500 mg vitamin c (test group) or placebo (control group) for 2 months. clinical parameters will be retrieved at baseline, at the end of week 4 and at the end of week 8.


Eligibility criteria:
inclusion criteria: * uncontrolled type 2 diabetes mellitus * periodontitis exclusion criteria: * complications from diabetes mellitus, e.g., renal insufficiency * receive insulin * diseases that interfere with wound healing, e.g., hiv * receive one of the followings: tetracycline, acetaminophen, nsaid, warfarin, aluminum-containing antacids, barbiturates, phenobarbital, pentobarbital, secobarbital, hormone replacement therapy, chemotherapeutic drug, protease inhibitor * receive other vitamins or antibiotics within 6 months * smoking * pregnancy

Keywords: uncontrolled type 2 diabetes mellitus periodontitis non surgical periodontal treatment vitamin c
immunonutrition and quality of life of cancer patients undergoing oncological treatment

Conditions: Gastrointestinal Cancer

Summary: the purpose of this study is to compare the health-related quality of life following dietary supplementation with an immunonutrition formulation vs an isocaloric/isoprotein control diet supplement in patients suffering from upper digestive tract neoplasia undergoing oncological treatment.


Eligibility criteria:
inclusion criteria: * histologically proven gi cancer. * age ≥ 18 years. * life expectancy more than 3 months. * female patients of child-bearing potential must be willing to employ effective contraception during the study period. * female patients of child-bearing potential must have a negative serum beta human chorionic gonadotrophin (βhcg) test at visit 0. * the patient is able to communicate effectively with study personnel and is considered reliable, willing, and cooperative in terms of compliance with the protocol requirements. * the patient voluntarily gives written informed consent to participate in the study. exclusion criteria: * severe concomitant clinical conditions other than the previously untreated digestive tract cancer that jeopardise the protocol follow-up. * the patient is pregnant or is a lactating woman. * currently participating or having participated in another interventional clinical trial related to nutritional support during the 30 days prior to the beginning of the study product intake, except if this other interventional trial is testing new drug or surgical intervention. (note: participation in a prior or concurrent clinical trial not related to nutritional support does not exclude the patient from participation.) * other malignancies in the last 5 years (except for successfully treated in situ basocellular skin and in situ cervical uterine tumours). * patients with more than 20% weight loss over a 6 months period.

Keywords: quality of life cancer immunonutrition
melatonin for prevention of post stroke delirium

Conditions: Post Stroke Delirium

Summary: post stroke delirium is prevalent in 10-30% of all stroke patients. we aimed to investigate wether melatonin 2mg may prevent post stroke delirium.


Eligibility criteria:
inclusion criteria: * all patients with stroke, tia or ich admitted to our stroke unit or intemdiate care unit * stroke / ich /tia onset \<= 48h exclusion criteria: * rass \<=4 * severe dementia, psychosis or depression

Keywords: melatonin
individually tailored training prescriptions in cancer patients: the top study

Conditions: Cancer

Summary: the top study is a two-stage study on individually tailored endurance and resistance training prescriptions for breast and prostate cancer patients after the end of primary therapy in order to optimize training effects.

the top study is a two-stage study on individually tailored endurance and resistance training prescriptions for breast and prostate cancer patients after the end of primary therapy in order to optimize training effects. the top study part i aims at identifying the most appropriate way of individual intensity prescription. in a descriptive cross sectional study, 20 breast and 20 prostate cancer patients perform singe endurance and resistance training sessions prescribed by means of different methods of intensity prescription. the most appropriate method of intensity prescription is identified through considering predictability/homogeneity of physiological responses as well as perceived exertion and enjoyment. the top study part ii aims at investigating the most effective training method in terms of enhancing physical fitness for both endurance and strength training. the design is an exploratory four-arm 12-week randomized controlled training intervention trial in 60 breast and 60 prostate cancer patients. in two endurance arms, vigorous continuous training is compared to a polarized program consisting of moderate training and aerobic high intensity interval training (hiit). similarly, in two resistance training arms, standard machine based hypertrophy training is compared to training following a daily undulating periodization design.

Eligibility criteria:
inclusion criteria: * diagnosed with early stage breast cancer (m0) or prostate cancer (m0 or m1 with psa evidence of stable disease) * 6 to 52 weeks after the end of primary therapy * ≥18 to 75 years of age * no regular endurance or resistance training (≥ one session per week) since diagnosis or within the last 6 months * sufficient german language skills * willing/ able to train at the provided exercise facilities twice per week and to take part in the scheduled testing * signed informed consent. exclusion criteria: * diagnosed with additional other cancer * brain or bone metastases in m1 prostate cancer patients * heart failure \>nyha iii, unstable angina pectoris or severe arrhythmia * uncontrolled hypertension * reduced standing or walking ability * any other comorbidities that preclude participation in exercise testing or training.

Keywords: breast cancer prostate cancer exercise prescription high intensity interval training daily undulating periodization training aerobic training resistance training physical fitness exercise
a study of mek162 and amg 479 in patients with selected solid tumors

Conditions: Metastatic Pancreatic Adenocarcinoma; BRAF Mutated Melanoma

Summary: this is a multi-center, open-label, phase ib/ii study. first, the aim of the phase ib part is to estimate the mtd(s) and/or to identify the recommended phase ii dose(s) (rp2d) for the combination of mek162 and amg 479 (ganitumab), followed by the phase ii part to assess the clinical efficacy and to further assess the safety of the combination in selected patient populations. the dose escalation part of the study will be guided by a bayesian logistic regression model (blrm). at least 18 patients are expected to be enrolled in the dose escalation part. following mtd/ rp2d declaration, patients will be enrolled in three phase ii arms to assess efficacy of the combination as well as to better understand the safety, tolerability, pk, antibody concentrations and pd of the combination at mtd/rp2d. phase ii arm 1 will consist of approximately 25 patients with kras-mutant colorectal adenocarcinoma. phase ii arm 2 will consist of approximately 20 patients with metastatic pancreatic adenocarcinoma. phase ii arm 3 will consist of approximately 28 patients with mutant brafv600 melanoma. patients will be treated until progression of disease, unacceptable toxicity develops, or withdrawal of informed consent, whichever occurs first. all patients will be followed up - at minimum patients must complete the safety follow-up assessments 30 days after the last dose of the study treatment.


Eligibility criteria:
inclusion criteria: * patients aged ≥ 18 years * patients with advanced solid tumors (crc, melanoma) with documented somatic kras or brafv600 mutations in tumor tissue. patients with metastatic pancreatic adenocarcinoma may be enrolled irrespectively of kras or brafv600 mutational status. * patients must have relapsed or progressed following standard therapy or patients for whom no standard anticancer therapy exists. * measurable disease as determined by recist v1.1. world health organization (who) performance status (ps) ≤ 2. * adequate organ function * negative serum pregnancy test exclusion criteria: * prior therapy with mek- or igf-1r- inhibitor * history or current evidence of central serous retinopathy (csr), retinal vein occlusion (rvo) or retinal degenerative disease * patients with known history of severe infusion reactions to monoclonal antibodies * patients with primary cns tumor or cns tumor involvement * history of thromboembolic event requiring full-dose anticoagulation therapy * clinically significant cardiac disease * history of another malignancy within 2 years * pregnant or nursing (lactating) women other protocol-defined inclusion/exclusion criteria may apply

Keywords: mek162 amg 479 ganitumab colorectal adenocarcinoma pancreatic adenocarcinoma melanoma kras braf
phase iii expansion trial for determining the safety and efficacy of recombinant human coagulation factor viii-fc fusion protein for injection in adolescent and adult patients with hemophilia a

Conditions: Hemophilia A

Summary: the primary objectives of the study are to further evaluate the efficacy and safety of recombinant human coagulation factor viii-fc fusion protein for injection (frsw107) in adolescent and adult patients with hemophilia a.


Eligibility criteria:
inclusion criteria: * patients who have completed trial of rh-107-001 (previously treated patients) previously received recombinant human coagulation factor viii-fc prophylactic. * the patient and/or guardian or his or her legal representative must be able to read, understand, and provide signed informed consent, and voluntarily signed the informed consent form. * the compliance of patients appeared quite well. * patient who is considered by the investigators suitable for ongoing to accept previously treated. exclusion criteria: * subjects who have not completed trial of rh-107-001or who have completed the phase iii clinical trial but not willing to continue receiving treatment. * subjects who did not participate in the phase iii clinical trial of rh-107-001.

Keywords: hemophilia a factor viii-fc fusion protein phase iii expansion trial efficacy and safety
safety and efficacy of integrative korean medicine treatment for elderly after traffic accident

Conditions: Musculoskeletal Diseases or Conditions; Traffic Accident; Elderly (People Aged 65 or More)

Summary: the purpose of this study was to analyze the medical records of elderly traffic accident patients hospitalized at 4 branches of jaseng korean medicine hospital to determine the status of elderly patients and the effectiveness and safety of korean medicine combination treatment.

this study was retrospective chart review study and was conducted in 4 branches of jaseng korean medicine hospital (gangnam, bucheon, daejeon, haeundae).

Eligibility criteria:
inclusion criteria: * patients aged 65 years or older at the time of first visit * patients who visited our hospital due to symptoms caused by a traffic accident and received integrated oriental medicine treatment at least once as an inpatient treatment exclusion criteria: * if only consultation was conducted at the hospital or only western medicine treatment was conducted * if only outpatient treatment was received without hospitalization * if other researcher judges that participation in the study is difficult

Keywords: pharmacopuncture herbal medicine elderly korean medicine complementary and alternative medicine acupuncture