Kornimate/medical-research-clean huggingface dataset:
evolution of management strategies of heart failure patients with implantable defibrillators

Conditions: Heart Failure; Sudden Cardiac Death; Implantable Defibrillator

Summary: the evolvo study is designed to compare the remote defibrillator management to the current standard of care, to assess its ability to treat and triage patients more effectively.

heart failure patients with implantable defibrillators (icd) perform frequent clinic visits for routine device monitoring. moreover, in case of clinical events, such as icd shocks or alert notifications for changes in cardiac status or safety issues, they often visit the emergency department or the clinic for an unscheduled visit. these planned and unplanned visits create a great burden on healthcare providers. internet-based remote device interrogation systems, allowing physician's remote access to patients' data, are being proposed for reducing routine and interim visits and for earlier detection and notification of alert conditions.

Eligibility criteria:
inclusion criteria: * patient with left ventricular systolic dysfunction, left ventricular ejection fraction ≤35%, as documented at the moment of icd implant; * patient implanted with a wireless-transmission-enabled medtronic icd or crt-d; * patient must be able and willing to replace regularly-scheduled in-office routine follow-ups with remote follow-ups; * patient must be able to attend all required follow-up visits at the study center. exclusion criteria: * patient is less than 18 years of age; * patient is unwilling or unable to sign an informed consent; * patient life expectancy is less than 12 months; * patient is participating in another clinical study that may have an impact on the study endpoints.

Keywords: heart failure implantable defibrillator remote monitoring
physiotherapy in emergency department: a service analysis from a french hospital

Conditions: Fall Patients; Pain; Sprains; Respiratory Insufficiency; Vertigo; Illness Behavior

Summary: the skills of physiotherapists have been employed to enhance access to optimal care in emergency departments (ed). no study has yet been conducted on the practices in france. the primary objective of this study was to describe the french practices of physiotherapy within an ed, and to secondary examine the effect on patient discharge.

a retrospective observational study was conducted on patients who received a referral for physiotherapy in the ed (e-pt) of the universitarian hospital of nantes during a six-month observation period in 2022. a total of 461 medical records were extracted, including patient characteristics and the main chief complaint at the time of admission. details on the delivery of e-pt were collected, as well as the end status at the exit of the ed. descriptive statistics were performed to analyse the data. a propensity score analysis examined the association between the patients' status at the exit of the ed and e-pt.

Eligibility criteria:
inclusion criteria: * admission in the emergency departement * aged over 18 * refferal for physiotherapy within the emergency department exclusion criteria: * death * no admission within the emergency department (only administrative purposes)

Keywords: physical therapy patient pathway patient care management
cluster-randomized controlled trial of mindfulness-based cognitive therapy effects on anxiety and stress

Conditions: Anxiety; Stress

Summary: to understand the potential effectiveness of a 4 week mindfulness-based cognitive therapy intervention delivered using a smartphone application for reducing anxiety and stress within college students.

the objective of this project is to understand the potential effectiveness of a 4 week mindfulness-based cognitive therapy intervention delivered using a smartphone application for reducing anxiety and stress within college students. although in-person mindfulness-based cognitive therapy approaches have been found effective for reducing anxiety and stress; given the pervasiveness of anxiety and stress in this population, there is a need to provide alternative and accessible interventions to improve students' mental health. one such approach may be by leveraging existing tools such sanvello - a free mindfulness-based cognitive therapy smartphone application - which could more easily be deployed across a broader population. accordingly, using a cluster-randomized controlled design, this intervention will assess the extent to which 4-weeks of using the sanvello application was effective for reducing anxiety and stress within college students.

Eligibility criteria:
inclusion criteria: * enrolled in course exclusion criteria: * complete inattendance in course during the pretest and study period. * opted out of data being available for research use

Keywords: mindfulness-based cognitive therapy
transitional care model for patients with stroke

Conditions: Stroke

Summary: patients with stroke benefitted from superior improvements in physical function, particularly when performing activities of daily living, fewer visits to the emergency room, less depression symptoms, and improved health-related quality of life thanks to transitional model care. despite widespread implementation of transitional care for stroke patients, intervention effectiveness remains inconclusive, and another concern with transitional care for patients is the scarcity of effects on specific findings.

a stroke may be a profound and life-changing occurrence for both the survivors and those who care for them, mandating participation in the adaptation and reinvention of a new post-stroke lifestyle that is sometimes unpredictable and temperamental. the sudden onset of a stroke and its accompanying treatment in an acute hospital setting can be distressing for both patients and caregivers. admission after stroke may have a profound impact as patients and their caregiver start to understand the effects of the occurrence, which is scary, puzzling, and stressful. nonetheless, adjusting to situations or life after a stroke might be made easier by implementing relevant and timely strategies throughout hospitalization, discharge, and the post-discharge period. both populations, stroke patients and caregivers, may have unmet needs once the patients are discharged at home, such as communication, recovery plan and process, medicine, emotional needs, and stroke information, as well as social involvement. to address unmet needs after discharge from the hospital to a variety of settings, such transitional care is recommended to tackle the adverse outcomes.one of the widely used transitional care models is tcm, which was developed at the university of pennsylvania under the direction of a nurse and was then made available to patients who were elderly at risk of poor outcomes and suffering from chronic illnesses including stroke patients. incorporated into the model, tcm were developed to meet the needs that arose during hospitalization and to provide continuity of care for patients, including those with stroke, who were unable to receive it after their acute illness treatment

Eligibility criteria:
inclusion criteria: * being at least 18 years old, being admitted in neurology department for at least 24 to 48 hours, * not having cognitive impairment as measured by the montreal cognitive assessment (score ≥ 23), * being able to communicate in indonesia, having the ability to provide informed consent, * being willing to participate in this study during hospitalization and 8 weeks after hospital discharge exclusion criteria: * have potentially biased information, such as being unable to provide informed consent due to cognitive impairment, * having major speech and language problems or aphasia that prevent them from participating in the study, * having serious psychiatric disorders or other with terminal disease requiring active treatment, and * being discharged to a nursing home or welfare institution.
the management of perforated acute appendicitis in adult and pediatric populations

Conditions: Perforated Appendicitis

Summary: patients admitted at marshall health - cabell huntington hospital with the diagnosis of acute perforated appendicitis or appendicular abscess larger than 3cm will be admitted and treated with percutaneous drainage and the iv antibiotics for 3 days. if the patient becomes afebrile and has a normal wbc, the patient will stay in the hospital for a single day with oral antibiotics and then will be discharged to continue oral antibiotics for seven more days. if the patient is febrile or has elevated wbc either after the 3 days of iv antibiotics or the single day of oral antibiotics, the patient will complete a course of iv antibiotics for a total of seven days. if still febrile, the patient will undergo further assessment. a follow up will be conducted \~10 days after discharge from the hospital to determine if the patient is still symptomatic or asymptomatic. asymptomatic patients will be followed up every month for 3 months, while symptomatic patients will be treated as needed. after 12 weeks, subjects will be randomized to interval appendectomy vs observation. follow-ups will occur every 3 months for 12 months, when the study will be concluded.


Eligibility criteria:
inclusion criteria: * men and women of all ages. * clinical and radiological diagnosis by contrast ct scan of acute perforated appendicitis. * formal consent for the present study must be signed by the patient or his/her parents * patients with initial presentation of a phlegmon (abscess in evolution) exclusion criteria: * patients with non-perforated appendicitis * presentation with initially non-perforated appendicitis but found perforation at surgery * patient with septic shock * patients who had previous appendectomy * current treatment of malignancy * immunocompromised patients * positive pregnancy test * no consent for the study

Keywords: perforated appendicitis pediatric appendicitis appendectomy appendiceal abscess antibiotic therapy
lapatinib in chemotherapy-naive or metastatic breast cancer

Conditions: Neoplasms, Breast

Summary: this phase ii study will evaluate and compare the efficacy and tolerability of two dose schedules (1500 mg qd and 500 mg bid) of oral lapatinib as treatment for patients with advanced or metastatic breast cancer.


Eligibility criteria:
inclusion criteria: * histologically confirmed invasive breast cancer with incurable stage iiib, iiic with t4 lesion or stage iv disease at primary diagnosis or at relapse after curative intent surgery. * eastern cooperative oncology group (ecog) performance status 0 or 1. * documented amplification of erbb2 by fluorescence in situ hybridization (fish) * measurable disease by response evaluation criteria in solid tumors (recist) * adequate renal, hepatic and cardiac function exclusion criteria: * prior chemotherapy, immunotherapy, biologic therapy or anti-erbb1/erbb2 therapy other than adjuvant therapy. \[prior neo-adjuvant or adjuvant therapy (including trastuzumab) will be allowed provided it was stopped at least 12 months before study entry. * patients with active brain metastases * patients with bilateral breast cancer, bone metastases as the only disease site or metastases to more than 30% of the hepatic parenchyma.

Keywords: lapatinib advanced metastatic breast cancer gw572016 erbb2
community-based maintenance exercise program for copd

Conditions: Chronic Obstructive Pulmonary Disease

Summary: it is well established that individuals living with chronic obstructive pulmonary disease (copd) demonstrate significant improvements following a formal rehabilitation program. the problem lies in the fact that these functional improvements diminish over a 12 month period. this decline in function is associated with decreased participation, a decline in health status, and an increased need to access the healthcare system. the objective of this project is to evaluate the effectiveness of a post-rehabilitation community-based exercise program for individuals with copd and compare the outcomes with those achieved through standard care. individuals with copd who have completed a previous rehabilitation program will be enrolled in the study. study participants will be assigned randomly to either a year-long community exercise program or usual care. those assigned to the community program will exercise twice weekly at a local community centre supervised by trained fitness instructors. a case manager will facilitate the transition from the hospital rehabilitation program to the community centre. the case manager will also be available to participants and instructors for consult as needed. continuing to build on an established partnership with the city of toronto, the case manager will ensure fitness instructors receive specialized training in order to properly supervise and support the individuals with copd. participants assigned to usual care group will receive standard care by their family physician and respiratory specialist. functional status will be evaluated before the program begins and again at 6-months and 1-year. the outcome of each group will be compared to determine the effectiveness of the community exercise program. it is hypothesized that individuals who participate in the community exercise program will have better function and quality of life versus those individuals who receive standard care.


Eligibility criteria:
inclusion criteria: * individuals with moderate to severe copd based on international (gold) criteria * clinically stable * able to provide their own informed consent * able to secure independent transportation to the community site exclusion criteria: * individuals with associated medical conditions that limit their exercise tolerance (cardiovascular, musculo-skeletal, recent surgery, etc.) * individuals who report a history of significant cardiovascular disease (i.e. congestive cardiac failure, history of cardiac arrest, acute myocardial infarction within the preceding three months, symptomatic ischaemic cardiac disease, uncontrolled systemic hypertension) or report severe non-respiratory symptoms during exercise * individuals receiving mechanical ventilation * individuals who are unable to attend the community-based exercise program or follow-up assessment sessions

Keywords: copd, exercise, community
melatonin for fatigue and other symptoms in patients with advanced cancer

Conditions: Cancer; Fatigue

Summary: background: patients with advanced cancer often suffer from fatigue and other symptoms and problems such as insomnia, appetite loss and pain. problems that may have great consequences for their quality of life. several studies suggest that a supplement of the hormone melatonin (mlt) may have a beneficial effect on these symptoms/problems. this needs further investigation. aim: to investigate if a supplement of melatonin have an effect on a) fatigue (the primary outcome of the trial), b) the symptoms insomnia, appetite loss, depression and pain, and c) overall quality of life. methods and patients: the trial takes place in the department of palliative medicine, bispebjerg hospital, and 50 patients will participate. the participants have to be 18 years or above, have advanced cancer, and suffer from quite a bit or very much fatigue. the study consists of two parts. in part i it is investigated if melatonin has a better effect than placebo on the outcomes mentioned above. this part is a consecutive, prospective, double blinded, randomized (mlt vs. placebo), cross-over study where the patients serve as their own control. in part ii the effect of melatonin over time is investigated. part ii is a consecutive, prospective, open-label study. the outcomes are assessed with weekly questionnaires (mfi-20 and eortc qlq-c15pal) and a few daily diary questions. melatonin has been used in several studies, and the general conclusion is that it is a safe substance with few adverse drug reactions. perspectives: if melatonin has the potential to alleviate fatigue and other symptoms in patients with advanced cancer and enhance the quality of life of these patients, this will be of benefit to many future patients. trials such as this are important both nationally and internationally to develop an evidence-based palliative medicine.


Eligibility criteria:
inclusion criteria: * answered "quite a bit" or "very much" to the question "were you tired?" (from eortc qlq-c15-pal) * cancer in a palliative phase * written informed consent * age 18 years or above exclusion criteria: * not capable of understanding or judging information, or fill out a questionnaire * untreated anemia (hb \<= 6,0 mmol/l) * untreated hypocalcaemia * systolic blood pressure \< 100 * in treatment with coumadin * receiving unstable doses of methylphenidate, corticosteroids or sleeping medicine the past two weeks * tsh \ 5.50 mcl/ml * pregnant or breast feeding

Keywords: melatonin palliative care advanced cancer symptoms quality of life randomized controlled trial
a open study to evaluate the performance of dressing on subject with high risk of skin breakdown

Conditions: Critical Illness

Summary: the rational for the study is to add a thin self-adherent dressing on critically ill patients. evaluate if the dressing might protect the skin for further breakdown.participants will be followed for the duration of hospital stay, an expected average of 5 days.


Eligibility criteria:
inclusion criteria: * provision of written informed consent * braden total score ≤ 12 at enrolment * male or female, ≥ 18 at enrolment * no skin- breakdown * subject or family member is able to understand and comply with the requirements of the study, judged by the investigator exclusion criteria: * risk area dosen´t fit the dressing size * documented skin disease * kown allergy to any of the components in the dressing * previous enroled in present study * subject included in other ongoing clinical investigation
admission of the patient to the clinic after surgery

Conditions: Post Operative Pain; Post-Op Hemorrhage; Postoperative Hypothermia; Nurse's Role

Summary: aim:this research was designed as a randomized controlled study to examine the effect of the game-based virtual reality learning method on the patient's post-operative admission to the clinic on the learning outcomes of the students. desing: this study was designed as a randomized controlled study to examine the effect of the game-based virtual reality learning method on the patient's post-operative admission to the clinic on the learning outcomes of the students. metod: the universe of the research will be nursing students who have taken the surgical diseases nursing course at gazi university faculty of health sciences nursing department in the 2021-2022 academic year. as a result of the power analysis using the g-power 3.1.9.7 package program; the effect size was calculated as 0.40 (it was seen from the literature studies that the effect size of the change in the knowledge score of the two groups was large effect size), and the total number of 68 samples is sufficient with 90% power, 5% margin of error, 95% confidence level, 20% drop-out considering the rate of study, it was found sufficient to work with at least 82 people (experiment: 41, control: 41). for research data, "descriptive features form", "knowledge test form", "skill evaluation checklist", "student opinions form about game-based virtual reality game application", egameflow scale will be used.


Eligibility criteria:
inclusion criteria: * students who voluntarily participated in the study * students who have taken all the subjects of the surgical diseases nursing course * students with smartphones, tablets, computers * students with internet access exclusion criteria: * students who do not participate in the theoretical training * students who take the surgical diseases nursing course from below * students who do not want to continue the research * students who do not fill out the data collection forms at any stage * students who do not participate in the virtual reality-based game application * students who do not participate in any of the skills assessment * students who fill in the data collection forms incompletely

Keywords: post operative pain post operative hemorrhage nursing care
effects of intravenous laser irradiation of blood treatment with different colored lights on controlling recurrent stroke risk factors and neurological function in stroke patients

Conditions: Stroke

Summary: introduction and purpose: patients with stroke have over a decade of experience with vascular laser treatment. previous studies predominantly used low-energy vascular lasers with red light, specifically helium-neon lasers with a wavelength of 632.8nm. however, different colored lights are absorbed by cells in the body in varying proportions, leading to potentially different effects. therefore, there is an interest in understanding the impact of other colored lights on stroke patients. to understand the practical effects of low-energy laser treatment with different colored lights on improving neurological function and controlling recurrent stroke risk factors. methods: a randomized crossover trial will be conducted with a study population consisting of individuals aged 20 and above who have experienced their first stroke within the last 6 months. exclusion criteria include patients with skin conditions unsuitable for injection or light exposure, those with light allergies, pregnant individuals, those with abnormal blood clotting function, those with implanted pacemakers, and individuals unable to comply with the 5-month study plan. participants will undergo 10 sessions of infrared light and 10 sessions of blue light vascular laser treatment. blood tests and neurological assessments will be conducted before each treatment session (10 irradiations) and at the end of the two-month washout period between the two different colored lights. descriptive analysis and pair t-tests will be employed to compare baseline values between the two groups. subsequently, repeated measures anova will be used to analyze differences between the intervention group and the control group. the study will examine whether various influencing factors are associated with receiving vascular laser treatment with different colored lights.


Eligibility criteria:
inclusion criteria: 1. diagnosed as a first-time stroke patient. 2. onset of illness within 6 months of enrollment. 3. recruitment period from january to december of the year 113. 4. all participants or their legal representatives must sign the informed consent form. exclusion criteria: 1. skin diseases that make injection or photosensitivity unsuitable. 2. pregnancy and abnormal blood clotting function. 3. presence of a cardiac pacemaker. 4. inability to comply with the 5-month study plan.

Keywords: stroke intravenous laser irradiation of blood recurrent stroke risk factors