Kornimate/medical-research-clean huggingface dataset:
hand exercises in psoriatic arthritis

Conditions: Psoriatic Arthritis; Hand Rheumatism

Summary: this study is a randomized controlled study examining the effects of 8-week hand home exercises on grip strength, functionality, disease activity and quality of life in patients with psa. individuals participating in the study will be randomly divided into 2 groups. individuals in the intervention group will perform home exercises consisting of stretching, mobility and strengthening, 4 days a week for 8 weeks, and the patients' compliance with the exercise will be monitored by phone call once a week. individuals in the control group are on the waiting list and the same home exercise program will be taught to the patients at the end of the study.

psoriatic arthritis (psa) is a chronic inflammatory musculoskeletal disease that is in the spondyloarthritis group and is frequently accompanied by peripheral arthritis, dactylitis, enthesitis, spondylitis and accompanied by psoriasis. although hand effects in patients with psa are known, there is no exercise study performed only on the hand and no study examining the effect of this study on the grip strength and functionality of the hand. this study is a randomized controlled study examining the effects of 8-week hand home exercises on grip strength, functionality, disease activity and quality of life in patients with psa. 34 individuals with psa who meet the inclusion criteria will be included in the study. individuals participating in the study will be randomly divided into 2 groups. individuals in the intervention group will perform 30-45 minutes of home exercises consisting of stretching, mobility and strengthening, 4 days a week for 8 weeks, and the patients' compliance with the exercise will be monitored by phone call once a week. individuals in the control group are on the waiting list and the same home exercise program will be taught to the patients at the end of the study. evaluations will be made twice, at the beginning and at the end of the 8-week program. in the evaluation, the demographic form, psoriatic arthritis disease activity score (dapsa), grip strength, nine-hole peg test, duruöz hand index, michigan hand outcome questionnaire (mhq) functional hand index, psoriatic arthritis quality of life questionnaire (psaqol) will be applied. this study will be one of the first studies to show the effects of hand exercises on psa disease activity, grip strength, functionality and quality of life.

Eligibility criteria:
inclusion criteria: * being diagnosed with psa by a physician according to caspar criteria * being 18 years or older * involvement in hand joints (pain, swelling, tenderness) * being on stable drug treatment for the last 6 months * having sufficient cooperation to participate in the study * volunteering to participate in the study exclusion criteria: * having difficulty cooperating at work * having additional orthopedic and/or neurological disease that will affect hand functions

Keywords: psoriatic arthritis hand exercises grip strength functionality disease activity quality of life
localizing the epileptogenic zone with high resolution electroencephalography

Conditions: Partial Epilepsy

Summary: multicenter prospective study comparing the diagnosis value of high-resolution eeg and depth-eeg to localize the epileptogenic zone in drug resistant partial epilepsies.


Eligibility criteria:
inclusion criteria: * medically intractable patial epilepsy confirmed by video-eeg recordings of epileptic seizures. * depth eeg (stereo-eeg) required to delineate the epileptogenic zone and define the surgical procedure. * full informed consent of the patient (or of his/ her legal representative) * 15 year or older patient exclusion criteria: * contraindication to cortectomy * contraindication to depth-eeg * indication of epilepsy surgery without depth-eeg monitoring * high grade glioma, arterio-veinous malformations * pregnancy * history of severe cardio-vascular event (coronaropathy, stroke)

Keywords: diagnosis partial epilepsy
effects of cold atmospheric plasma (cap) on peritoneal tumor tissue

Conditions: Cold Atmospheric Plasma (CAP); J-Plasma; Peritoneal Tumor

Summary: there are to date no studies available that have examined the effects of cap on tumor tissue in patients. the aim of this study is to investigate these effects in patients undergoing surgery for peritoneal metastases. tumor nodules will be treated with different durations and intensities of cap before being surgically removed. the resected nodules will be analyzed for tumor vitality.


Eligibility criteria:
inclusion criteria: * patients with peritoneal metastases undergoing surgery (crs, debulking), irrespective of the origin. potential cancer types include ovarian cancer, colorectal cancer, and malignant peritoneal mesothelioma * written informed consent * age ≥ 18 years.
safety and efficacy study of axid use in infants suffering from gastroesophageal reflux disease (gerd)

Conditions: Gastroesophageal Reflux Disease; GERD; Heartburn

Summary: the objective of this study is to evaluate the efficacy, acceptability, and safety of axid oral solution versus placebo in the treatment of gastroesophageal reflux disease (gerd) in infants age 30 days up to 1 year.


Eligibility criteria:
inclusion criteria: * male or female outpatients age 30 days up to 1 year at visit 1. * subjects must have a documented medical diagnosis of gastroesophageal reflux disease (gerd), confirmed by either endoscopy or ph monitoring, or by evaluation of baseline symptoms. * subjects must be greater than the 3rd percentile of weight and height for their age. * parents/guardians are competent and willing to provide consent and sign and date the institutional review board (irb) approved consent form. * parents/guardians are willing to adhere to study requirements, including applying the conservative gerd management methods. * conservative gerd management methods have failed to adequately control gerd symptoms by visit 2. * parent/guardian and infant live in the same household. * qualifying caregiver questionnaire score at visits 1 \& 2. exclusion criteria: * any known esophageal disease or disorder, other than reflux esophagitis. * any active gastroduodenal ulceration, or clinical or endoscopic evidence of active gastrointestinal bleeding. * any prior esophageal or gastric surgery. * concurrent serious systemic disorders, including chronic respiratory disease, chronic neurologic disease, chronic renal disease, chronic liver disease. * subjects with clinically significant abnormal laboratory findings at screening. * premature infants \< 37 weeks gestation at birth. * infants with prior neonatal intensive care unit admission for any reason. * hematemesis or apparent life-threatening events (alte). * concurrent treatment with any chronic medication except by permission of the study sponsor. * treatment with a histamine 2 receptor antagonist (h2ra), antacid, sucralfate, prostaglandin, or motility agent within 3 days before visit 1; treatment with a proton pump inhibitor within 7 days before visit 1. * requirement or likely requirement for a medical procedure or surgery during the study. * known hypersensitivity to an h2ra including nizatidine. * receipt of any investigational agent within the previous 30 days before randomization. * poor medical or psychiatric risks for therapy with an investigational drug, in the opinion of the investigator. * any condition in parent/guardian associated with poor subject compliance e.g., substance abuse); inability of parent/guardian to return for scheduled visits with their child.

Keywords: gastroesophageal reflux disease gerd heartburn
effects of personalized music listening in advanced alzheimer's

Conditions: Alzheimer Disease, Late Onset; Cognitive Impairment

Summary: recent functional imaging studies have facilitated a better understanding of the neuroplasticity mechanisms underlying the strong and multifaceted effects of music on brain development. for this reason, music is considered a significant factor in improving recall and mood in individuals with dementia. a review investigating the cognitive and behavioral effects of music listening in alzheimer's disease (ad) reported that personalized (individualized) music listening yielded the best outcomes. this study aims to examine the effects of personalized music activities on functional and cognitive status in individuals with advanced-stage ad.


Eligibility criteria:
inclusion criteria: * aged 65 and over * patients diagnosed with advanced-stage alzheimer's type dementia according to the diagnostic criteria of the american psychiatric association's diagnostic and statistical manual of mental disorders (dsm-v) exclusion criteria: * patients with hearing impairments that could interfere with music listening * individuals who have received music education and are able to play an instrument * patients with a history of heart disease, hypertension, or diabetes will be excluded from the study.
radical surgery for advanced gastric- or gej-cancer with oligometastatic dissmination to the liver

Conditions: Survival

Summary: offering treatment with potential to cure for participants with no such offer in today's standard treatment options, by offering metastatectomia and standard treatment with intention to cure i.e., neoadjuvant chemotherapy and gastrectomy for participants with gastric- og gastroeusofageal junction cancer. including 20 participants from all 4 centres in denmark able to perform the surgical procedures in question. endpoints: 2-year overall survival.


Eligibility criteria:
inclusion criteria: * age \> 18. * presence of primary t1-t4n0-n3m1 adenocarcinoma of the stomach or gej and max. 30% liver involvement. * primary tumour resectable, based on imaging workup. * surgical operable patients with asa-score36 ≤ iii and who performance status37 0-1. * patients eligible for treatment with systemic chemotherapy by flot regimen. * informed consent is obtained. exclusion criteria: * patient with non-resectable cancer. * direct growth involving adjacent organs, i.e., pancreas, colon, blood vessels or bones. * other malignant disease diagnosed or treated up to 2 years prior to inclusion, except non-aggressive cancers such as non-melanoma sin cancer. * altered anatomy of the upper gastrointestinal tract due to previous surgery of the oesophagus, stomach, and duodenum. * bmi ≤ 18 * the patient is unable to understand and/or read the consent form. * other serious illness or acute infections. * pregnant or breastfeeding.
a longitudinal study of effect of copaxone in rrms over 24 months

Conditions: Multiple Sclerosis

Summary: to explore whether treatment with glatiramer acetate (ga) may decrease iron deposition in subcortical deep gm, as detected by swi-filtered phase imaging, in patients with rrms over 24 months and compared to a reference population of healthy controls.

this is a prospective, observational, single-blinded, longitudinal, 24-month mri study of the evolution of iron deposits, as evidenced by swi-filtered phase imaging, in rrms patients treated with ga and in healthy controls.

Eligibility criteria:
inclusion criteria: * ms patients diagnosed with clinically definite ms according to the mcdonald criteria (polman et al., 2005) * being on ga monotherapy (20mg/day sc) for at least 24 months prior to the 24-month mri scan * having baseline clinical mri scan that included swi-filtered phase imaging in a 12-month window from the start day of the of the ga (ms patients) * having baseline clinical mri scan that included swi-filtered phase imaging (healthy controls) * ms patients having a rr disease course (lublin and reingold, 1996) * age 18-65 (healthy controls will be matched to ms patients for age and sex) * signed informed consent at the 24-month follow-up * pass mri health screening * ms patients passing contrast screening * ms patients having normal kidney function (creatinine clearance \>59) * none of the exclusion criteria exclusion criteria: * patients who had a relapse within 30 days prior to mri baseline scan date * patients who received steroid treatment within 30 days prior to the mri baseline scan date * women who are pregnant, lactating or of childbearing age who do not consent to approved contraceptive use during the study * ms patients who used other imunomodulatory or immunosuppressant treatment other than ga during the follow-up (e.g., ifn-β, mitoxantrone, cyclophosphamide, cladribine, fludarabine, cyclosporine, total body, azathioprine, methotrexate, ivig, cellcept, natalizumab, etc.) * ms patients having abnormal kidney function (creatinine clearance \<59)

Keywords: multiple sclerosis mri copaxone healthy controls glatiramer acetate
the effect of extremely low frequency electromagnetic field device improving sleep and stress

Conditions: Stress; Sleep Quality; Fatigue; Extremely Low Frequency Electromagnetic Field Device; Schumann Resonance

Summary: the purpose of this study is to explore the effects of extremely low frequency electromagnetic waves on improving stress and sleep quality. experimental studies, pre- and post-test double-blind crossover tests are adopted. the selected subjects include: patients in the sleep center of the taipei medical university hospital and the department of nursing and bachelor of taipei medical university there are about 100 students in the post-nursing department. they are randomly assigned to groups a and b using a computer. the experiment period is two weeks. the two groups will take a pre-questionnaire test in the afternoon of the first day of the experiment and wear wearable bracelets. group a first after getting the device with low-frequency electromagnetic field, group b first got the device without low-frequency electromagnetic field. the appearance of the two is the same. the bracelet is worn from the afternoon of the first day to the afternoon of the fourth day, a total of three days, and the device is withdrawn at the end of the first stage the two groups exchanged, repeat the steps to complete the second stage, after the end of the post-test, the two groups plug in the device half an hour before going to bed every day, and put it on the bedside table about 20cm away from the head, and then turn off the device after getting up. the research tools are basic attribute questionnaires, sleep quality scales, sleep diaries, smart care vip bracelets, and eeg. among them, the wearable bracelet can monitor the stress index, fatigue index, calories burned, and walking steps. then spss 22.0 software is used for data file building and statistical analysis. the data is analyzed by descriptive statistics and inferential statistics. the expected result is that the experimental group and the control group have significant differences in reducing stress and improving sleep quality, which can relieve stress and improve sleep quality.


Eligibility criteria:
inclusion criteria: * under 20 years old,great mental health,bmi is between 18.5\~24(normal range). exclusion criteria: * cognitive disturbance, confusion, pregnancy, alcohol and caffeine addiction.

Keywords: extremely low frequency electromagnetic field device stress sleep quality fatigue hrv low energy emission therapy schumann resonance
the wats3d (wide area transepithelial sample biopsy with 3-dimensional computer-assisted analysis) u.s. registry

Conditions: Barrett Esophagus; Gastroesophageal Reflux; Esophageal Dysplasia; Esophageal Diseases

Summary: the purpose of this study is to create a registry (collect data and keep it in a research database) to learn more about two methods of taking small tissue samples from your esophagus (the esophagus is the tube that carries food and liquid from your mouth to your stomach.). the two methods of sampling are: 1) using forceps that take biopsies (small tissue samples) from your esophagus, and 2) using a brush that also takes biopsies from your esophagus. by recording the results of all of your biopsies over many years, it may be possible to find out if the brush biopsy, forceps biopsy, or both can predict which patients with heartburn develop barrett's esophagus, (an abnormality in the esophagus that may lead to cancer), and which patients with barrett's esophagus develop precancer and cancer. the data from your biopsies will be used to determine the best way to diagnose esophageal disease. you are being asked to participate in the study because you are receiving an upper endoscopy (a procedure where a tube with a light and camera are inserted in your mouth and down your throat) with forceps and brush biopsies of your esophagus as part of your standard clinical care, and you are between the ages of 18 and 80.


Eligibility criteria:
inclusion criteria: * english speaking * able to read, comprehend, and complete the consent form * aged 18 to 80, and, * meet one of the following: * patients with heartburn or regurgitation undergoing a screening egd, who undergo wats3d sampling and forceps biopsies for suspicion of be, or * patients with known be with or without dysplasia undergoing a surveillance egd with wats3d biopsies and forceps biopsies, or * patients who have undergone endoscopic eradication therapy(including, but not limited to endoscopic mucosal resection, endoscopic submucosal dissection, radiofrequency ablation and/orcryoablation/spray cryotherapy)who are undergoing surveillance egd following the establishment of complete eradication of intestinal metaplasia (ceim) with accompanying wats3d sampling and forceps biopsies. exclusion criteria: * patients meeting any of the following criteria will be excluded from this study: * patients who on their enrollment endoscopy have a visible highly suspicious lesion, such as a nodule or ulcer, (noted while undergoing endoscopy) that requires targeted biopsy will be excluded from the study.patients requiring a targeted biopsy on follow-up endoscopies will be allowed to remain in the study. * patients who do not undergo both biopsy forceps and wats3d biopsy of the esophagus on their initial evaluationfor routine care will be excluded from this study. subsequent endoscopicevaluation may include forceps biopsies alone, wats3d biopsies alone, or both forceps and wats3d biopsies.
delayed umbilical cord clamping versus cord milking in preterm neonate

Conditions: Premature Birth

Summary: this study is being done to evaluate if delaying cord clamping or milking the umbilical cord of the preterm infant has health benefits for the baby. timing of clamping of the cord varies among doctors, but there is information that shows that delaying clamping of the umbilical cord in premature infants may reduce the rate of the baby needing a blood transfusion, decrease the risk of infection and bleeding in the head.


Eligibility criteria:
inclusion criteria: * singleton or multiples pregnancies in patients admitted for medically indicated delivery or in advanced spontaneous preterm labor with imminent delivery at 24 0/7 - 28 6/7 weeks gestation * women ages 18 and older exclusion criteria: * planned vaginal breech delivery * major fetal abnormalities (defined as those that are lethal or require prenatal or postnatal surgery) * fetal death in utero * red cell isoimmunization * patients who are incapable of informed consent (unconscious, severely ill, mentally handicapped), or are unwilling to undergo randomization * placenta previa or other known abnormal placentation (e.g. placenta accreta)

Keywords: delayed cord clamping umbilical cord preterm cord milking
cachexia in nsclc patients: diagnosis, characterization, prognosis, functional and skeletal muscle implications

Conditions: NSCLC Stage IV

Summary: lucax01 is a cohort study with patients with advanced nsclc in tobacco users. in this study, patients will be submitted to baseline physical tests, blood and biopsy sample collection, and the main objective is to study the functional and prognostic implications of cachexia and to validate skeletal muscle dysfunction markers.

non-small-cell lung cancer (nsclc) is currently the neoplasm leading in deaths worldwide and in brazil, it figures as the second most common cancer in terms of the number of deaths. patients are usually diagnosed in advanced stages and, consequently, more than 45% of all patients are diagnosed with cachexia. this syndrome is characterized by a loss of muscle mass with or without fat loss and it cannot be reversed by nutritional support. in the physiopathology of cachexia, generally are present exacerbated inflammation, severe loss of muscle contractile proteins, leading to fatigue and increased mortality. furthermore, patients with cachexia usually do present lower response rates to anticancer treatments and it is also associated with a worse overall prognosis. treatments directed to mitigate muscle loss in these patients are awaited. cohort studies do suggest a significant positive impact of physical fitness and prognosis in different chronic diseases; however, its impact in advanced nsclc patients is not clear. here our aim is to better understand the relationship between cachexia and physical fitness variables (muscle and cardiorespiratory function, body composition, and daily physical activity level) with prognosis and mortality in a group of nsclc patients, as well as to study the effect of chemotherapy on these variables. besides that, will be evaluated the skeletal muscle, treg lymphocytes, and inflammatory biomarkers and compare cachectic and non-cachectic patients. sixty nsclc patients will be accrued. will be assessed the maximum oxygen consumption, daily physical activity, muscle function, muscle morphology, anxiety, depression, performance status, and fatigue pre-treatment. blood and muscle biopsy samples will be collected. the prognostic impact of these physical fitness variables will be defined, as well as their predictive value in terms of response to anticancer treatments in advanced nsclc patients.

Eligibility criteria:
inclusion criteria: * advanced stage iva or ivb nsclc patients histologically diagnosis. * eastern cooperative oncology group performance status 0 - 2 * treatment-naive * current smokers or ex-smokers * normal renal, hepatic and hematological functions * able to perform the physical functional tests * able to read and sign the consent form exclusion criteria: * initiate treatment before initiate * diagnostic of tumor mutation ( epidermal growth factor receptor, anaplastic lymphoma kinase) obs: a smoker population with no known cancer will be used as controls (n=10)

Keywords: cachexia skeletal muscle atrophy physical functional performance prognosis
effects of motor imagery on trapeziometacarpal osteoarthritis in women during the postoperative immobilization period

Conditions: Osteoarthritis Thumb; Immobilization

Summary: the aim of this study is to verify whether after trapeziometacarpal osteoarthrosis surgery and during the period of immobilization immediately after it, applying motor imagery, improvements are achieved on pain, strength, edema and / or inflammation, function and the joint range, accelerating the recovery process.

motor imagery (im) consists of a complex cognitive operation by which an action is simulated without doing it physically. many studies support the usefulness of motor imaging in rehabilitation after manual surgery. an approach based on motor imagery may be useful in trapeziometacarpal osteoarthritis, and may be used to promote motor recovery after surgical treatment.

Eligibility criteria:
inclusion criteria: * the participants on the surgical waiting list of the hospital of león exclusion criteria: * other hand pathologies

Keywords: mental practice motor imagery trapeziometacarpal osteoarthritis