Kornimate/medical-research-clean huggingface dataset:
superficial cervical plexus block and quality of recovery after thyroidectomy

Conditions: Postoperative Pain

Summary: the goal of this clinical trial is to learn whether a superficial cervical plexus block improves quality of recovery after thyroid surgery. investigators will compare a superficial cervical plexus block with bupivacaine compared to an identical procedure performed saline placebo to see if there is a difference in quality of recovery on the first postoperative day. the main question to answer is: • does a superficial cervical plexus block with bupivacaine compared to placebo improve quality of recovery in patients having thyroid surgery. participants will: * fill out an initial preoperative survey * be randomized to receive a superficial cervical plexus block with bupivacaine or saline placebo while under anesthesia before the surgery starts * fill out a survey about recovery on the first day after surgery

thyroid surgery is associated with mild to moderate post-operative pain, with most patients requiring opioid pain medicine postoperatively. nerve blocks, such as the superficial cervical plexus block, are an important component of pain control plans. superficial cervical plexus blocks have been proven to decrease pain and reduce the need for opioid medications in thyroid surgery. however, previous studies were performed before it became common practice to administer a combination of acetaminophen, nonsteroidal anti-inflammatory drugs (nsaids), and steroids for thyroid surgery which also help with pain. whether the superficial cervical plexus block improves pain control and quality of recovery in this context is unknown. this study aims to determine whether the superficial cervical plexus block has an impact on quality of recovery as measured by a survey called the quality of recovery-40 (qor-40).

Eligibility criteria:
inclusion criteria: * aged 18 years or older * american society of anesthesiologists physical status classification i-iii * provision of signed and dated informed consent form * stated willingness to comply with all study procedures and availability for the duration of the study * scheduled for thyroid surgery * access to smartphone device or computer with internet connection and has an email address exclusion criteria: * non-english speaking * american society of anesthesiologists physical status classification \> iii * have an intolerance or contraindication to the medications involved in the study * undergoing repeat thyroid surgery * undergoing surgery with planned neck dissection * plan for admission post-operatively * positive pregnancy test on day of surgery (for participants with child-bearing potential) * refusal to participate

Keywords: superficial cervical plexus block quality of recovery postoperative pain thyroidectomy
family-based behavioral medical nutrition therapy education in children and adolescents with type 1 diabetes

Conditions: Type1diabetes

Summary: type 1 diabetes mellitus (t1dm) is a heterogeneous condition and is an absolute insulin deficiency resulting from autoimmune-mediated destruction of pancreatic β-cells (1). the incidence of t1dm has been increasing globally since the 1950s, particularly in children, with an average annual increase of 3-4% over the past three decades.despite the advances in medical treatment and technology, nutritional therapy continues to be the main component of diabetes treatment. medical nutrition further improves metabolic control outcomes when t1dm care is combined with other treatments.this study was conducted to examine the effect of family-based behavioral medical nutrition therapy training on nutritional status and metabolic control in children and adolescents with type 1 diabetes.

the research was carried out with children and adolescents aged 8-18 years who were followed up with the diagnosis of type 1 diabetes mellitus in gaziantep cengiz gökçek gynecology and pediatrics hospital. the sample of the study was consisted of 75 (male= 36, female= 39) children and adolescents in total, including intervention 1 group (n=25), intervention 2 (n=25) group and control (n=25) group determined by double-blind, stratified, random method. medical nutrition therapy and carbohydrate counting training were given to mothers and children in the intervention 1 group, and only to children and adolescents in the intervention 2 group. the control group did not receive medical nutrition therapy and carbohydrate counting training. at the beginning (0. month) and at the end (6. month) of the study, 3 consecutive day/24-hour food consumption records and anthropometric measurements of the individuals were assessed, bmi z-scores and height z-scores were calculated, mediterranean diet quality index scale (kidmed), diabetes eating problems survey-revised (deps-r), physical activity questionnaire for children and adolescents (paq-c and paq-a) were administered and healthy eating index 2015 (hei-2015) scores were calculated. routinely assessed blood findings of the individuals were checked at the beginning (0. month), 3rd month and 6th month of the study.

Eligibility criteria:
inclusion criteria: * 8-18 years old, * being diagnosed with t1dm for at least ≥1 year, maximum ≤5 years, * latest hba1c ≥6.5% - \<13.5%, * receiving intensive insulin therapy (at least 3 times a day bolus and 1 time basal insulin administration or using an insulin pump), * no communication problems * children and adolescents without any other disease accompanying diabetes were included in the study. exclusion criteria: * celiac, cystic fibrosis etc. with gastrointestinal diseases, * using any drug that may affect glucose metabolism, * switched from an insulin pen to an insulin pump in less than 6 months, * involved in any other intervention work in the last 6 months, * and individuals with communication problems were not included in the study.

Keywords: type 1 diabetes, nutrition education, metabolic control
impact of symbiotic administration on intestinal function of head and neck patients surgically treated

Conditions: Head and Neck Cancer; Synbiotics; Nutrition Therapy

Summary: the purpose of this study is to determine whether the symbiotic use in patients with head and neck cancer impact on intestinal function after surgical treatment.

the study will be conducted offering the patients symbiotic product twice a day for seven days after the surgical treatment. patients will be monitored for the number of stools, stools consistency, abdominal pain and gas overproduction.

Eligibility criteria:
inclusion criteria: * head and neck cancer with primary surgical treatment, enteral nutrition by enteral tube. exclusion criteria: * three months antibiotic use earlier the surgery, recently radiotherapy or quimiotherapy, inflammatory bowel disease.
efficacy of puressentiel protective nasal spray in allergic rhinitis

Conditions: Allergic Rhinitis Due to Grass Pollen; Allergic Inflammation

Summary: this study is a proof o concept aiming to determine the efficacy of puressentiel nasal protective spray (pnps) in patients with allergic rhinitis. cross over study, with a nasal provocative test (npt) in patients with allergic rhinitis sensitized to grass pollen. a day 0 (first npt) the following outcomes are recorded: allergic rhinitis control test (arct) and inspiratory nasal peak flow (inpf) before and 30 min after the npt. nasal lavage is performed 30 min after the npt and 3 cytokines (il4, il5 and il13 are measured by elisa. an other npt is performed at day 30 and the same outcomes measured. 30 min before npt 2 nasal sprays of pnps are administered in each nostril in a randomized manner and cross over, the patient being is own control. the primary outcomes ins the il4, il5 and il13 concentrations in the nasal lavage. arct and inpf are the secondary outcomes.


Eligibility criteria:
inclusion criteria: * patients with diagnostic of allergic rhinitis sensitized to grass pollen for more than one year with or without associated asthma exclusion criteria: * patients sensitized to a perrianual allergen * patients with viral infection 4 weeks before inclusion * patients with severe non controlled asthma * patients with chronic sinusitis * pregnancy or breast feeding * patients with hypersensitivity to essential oil (eucalyptus radie) * epileptic patient * patients treated with nasal corticosteroid or anti-histamine
a therapeutic equivalence study of two oxiconazole nitrate topical cream treatments for patients with tinea pedis

Conditions: Tinea Pedis

Summary: the objective of this study is to demonstrate that oxiconazole nitrate 1% topical cream is effective for the treatment of patients with moderate to severe tinea pedis.


Eligibility criteria:
inclusion criteria: 1. male or non-pregnant, non-lactating female, 12 years of age or older. 2. signed informed consent form, which meets all criteria of current fda regulations 3. if female and of child bearing potential, prepare to abstain from sexual intercourse or use a reliable method of contraception during the study {e.g., condom, iud, oral, transdermal, injected or implanted hormonal contraceptives)and (must have used the same product for at least 30 days prior to the study start and use the same product throughout the duration of the study), transdermal or implanted hormonal contraceptives} 4. a confirmed clinical diagnosis of tinea pedis with lesions localized to the interdigital spaces or predominantly interdigital, but may extend to other areas of the foot. (the non-interdigital lesions should not be hyperkeratotic i.e., characteristic of moccasin). 5. the presence of tinea pedis infection, confirm by the observation of segmented fungal hyphae during a microscopic koh wet mount examination. exclusion criteria: 1. females who are pregnant, or lactating or likely to become pregnant during the study. 2. any known hypersensitivity to oxiconazole nitrate or other antifungal agents. 3. patients with a past history of tinea pedis infections with a lack of response to antifungal therapy (i.e. recurrent tinea pedis, more than 3 infections in the past 12 months, which were unresponsive to previous antifungal therapy). 4. participation in a research study in the past 30 days prior to screening/randomization.

Keywords: tinea pedis
the effect of liposome vitamin c on the absorption and metabolism of the human body.

Conditions: Vitamin C Deficiency

Summary: to evaluate the difference between vitamin c in the form of oral liposomes and general vitamin c in a fixed period of time in plasma and urine.

we recruited 11 healthy subjects and adopted a cross-over test. the subjects need to take 3 tests during trail. after each test was completed, a washout period of 14 days was required before the next test start. the subjects were informed to consume one sachet vitamin c without liposome, liposomal process a vitamin c, or liposomal process b vitamin c (double nutri™) every test, and vitamin c concentration was measured at baseline (0 hours), 0.5, 1, 2, 3, 4, and 8 hours after taking test sample.

Eligibility criteria:
inclusion criteria: 1. adults between 20-60 years old, 2. no heart, liver, kidney, endocrine and major organic diseases exclusion criteria: 1. renal insufficiency and dialysis 2. cancer 3. underweight (bmi≦17) or obese (bmi≧27), 4. take chronic disease drugs, 5. blood pressure systolic blood pressure ≧130 mmhg or diastolic blood pressure ≧85 mmhg, 6. too high fasting blood glucose ≧ 100 mg/dl, 7. triglyceride ≧ 150 mg/dl,total cholesterol ≧ 200 mg/dl, 8. have a history of vitamin c allergy, 9. people with mental illness, 10. pregnant or breastfeeding women, 11. hematosis, 12. kidney stones, 13. long-term vitamin c supplements (at least 200 mg per day for more than one month)
fluorescence and glioma heterogeneity

Conditions: Malignant Gliomas

Summary: the investigators aim to study the heterogeneity of fluorescence within malignant gliomas by sampling tissues from these variable areas within the same tumor. these tissue samples will then be subjected to pathological and biological analysis to assess proteins related to ala metabolism and correlated with the fluorescence emitted as well as levels of protoporphyrin ix in the tissues.

malignant gliomas are the commonest malignant brain tumors but are extremely challenging to treat. neuro-oncology has seen little progress in its treatment despite extensive research. extent of resection remains a very important prognostic factor in these tumors. better the resection, better the outcomes. however resecting these tumors is not very easy primarily due to their infiltrative nature and difficulty in discerning tumor boundaries intraoperatively. fluorescence guided resection (fgr) has recently been shown to be a very important and useful adjunct in maximizing this goal. fgr involves administration of aminolevulinic acid (ala) to the patient prior to surgery. the ala is converted to protoporphyrin ix (ppix) in glioma cells. the ppix is a fluorophore and can be visualized intraoperatively using a suitably modified microscope. neurosurgeons can then resect the tumor radically guided by this fluorescence which is superior to the conventional microscopic resection. selective ppix accumulation in glioma cells is the key to the accuracy of this technique. the biological basis of selectivity of ppix accumulation within glioma cells is however poorly understood. various mechanisms could be involved starting from variable transport (related to blood-brain barrier properties), differential uptake (governed by active transport mechanisms) and differential metabolism within the cell. understanding these mechanisms can lead to refinements in this strategy, overcoming its present limitations and development of methods to extend its scope.

Eligibility criteria:
inclusion criteria: per-primum glioma * adults (18-65 years) * radiologically suspected malignant gliomas * variable contrast enhancement on mri (patchy and/or non-uniform) * eligible for surgical therapy (craniotomy not stereotactic biopsy ) * no contraindication for surgery exclusion criteria: * poor general condition (kps \< 70) * prior treatment (except biopsy) * compromised renal/hepatic function * immunocompromised status * known photosensitivity / allergy to 5-ala

Keywords: ala malignant gliomas
non-hormonal vaginal moisturizer in hormone-receptor positive postmenopausal cancer survivors experiencing estrogen deprivation symptoms on vulvovaginal health

Conditions: Breast Cancer; Endometrial Cancer

Summary: the purpose of this study is to see whether it is feasible to conduct a study to determine if the use of hyaluronic acid (hla) vaginal gel (hyalogyn®) improves vulvovaginal health. this study aims to look at whether or not hyalogyn® is effective in women with a history of hormone receptor positive cancer and experiencing vaginal and/or vulvar symptoms of estrogen deprivation following their breast and endometrial cancer treatment.


Eligibility criteria:
inclusion criteria: * history of breast cancer or endometrial cancer confirmed at mskcc or outside pathology report * breast cancer patients must be at least 3 months post-active treatment (including chemotherapy, radiation therapy, endocrine therapy, and/or maintenance therapy), but not greater than 5 years post-active treatment (exception: ais are required, and monoclonal antibodies are allowed) * breast cancer patients must be currently on adjuvant aromatase inhibitors * endometrial cancer patients must be at least 3 months post-active chemotherapy and/or maintenance therapy treatment but not greater than 5 years post-active chemotherapy and/or maintenance therapy treatment. they must be at least 4 weeks post-radiation therapy (ebrt or ivrt) but not greater than 5 years post-radiation therapy. * endometrial cancer patients must have underwent surgical treatment (total abdominal hysterectomy (\[tah\]/bso)) and radiation therapy (external beam radiation therapy \[ebrt\] or ivrt) * currently have no clinical evidence of disease * menopausal at study entry as described by: * surgical menopause (tah/bso), or * age ≥ 50 years and cessation of menstruation for at least 1 year, or * age \<50 years and cessation of menstruation for at least 1 year with estradiol level in post-menopausal range, or * rendered post-menopausal with the use of lhrh agonist * patients who are new visits to female sexual medicine program or patients are not consistently using any vulvovaginal health promotion strategies (e.g., pelvic floor exercises, dilator therapy, moisturizers) recommended by the female sexual medicine program reporting being bothered by vulvovaginal symptoms of estrogen deprivation (i.e., vulvovaginal dryness or discomfort \[pain with intercourse or examination\]) * without history of other cancers (excluding non-melanoma skin cancer) * women at least 18 years of age * able to read and speak english * able to participate in the informed consent process exclusion criteria: * inability to provide informed consent * vaginal bleeding of unknown etiology within 12 months of study entry * currently taking hormone replacement therapy \[local or systemic\] (patients must discontinue for 2 weeks in order to be eligible prior to study enrollment)

Keywords: hyalogyn vaginal gel vaginal dryness 12-232
community-driven cervical cancer prevention in western kenya

Conditions: Human Papilloma Virus Infection; Carcinoma in Situ of Uterine Cervix

Summary: there are many challenges to implementation of cervical cancer prevention in resource-limited countries, despite evidence based screening and treatment strategies. the investigators hypothesize that self-collected hpv specimens offered in a community health campaign setting will


Eligibility criteria:
inclusion criteria: * female, ages 25-65 willing to sign informed consent lives in community where randomization arm is exclusion criteria: * prior hysterectomy

Keywords: cervical cancer screening human papillomavirus testing kenya implementation science
assessing current clinical concepts in dental practice

Conditions: Dental Implant

Summary: this purpose of this database is to collect, store and use appropriately derived data from routine patient care in a specialist dental practice. comprehensive observational data will be gathered, systematically organised and be continuously updated. this data will be used to evaluate treatment outcomes and identify areas for improvement. this will contribute to the existing evidence base to validate new and current clinical concepts in dentistry. patient consent will be sought for this, and all data extracted from patient notes will be stored and used anonymously. use of the oral health impact profile (ohip) -14 questionnaire pre and post treatment will be used to assess patient satisfaction with outcomes.

specialist dentistry uses a combination of techniques resulting from joint decisions between clinicians and patients, aimed at giving the patient what is perceived to be the best possible outcome. however, as new techniques and approaches develop, there is capacity for more evidence to justify one treatment option over another, both clinically and most importantly, from the patient perspective. the aim of this project is to set up a research database which will enable the collection and storage of appropriately derived data from routine patient care and from patient questionnaires (using ohip-14). this data will be used in cohort studies/case series reports/comparative studies with other practices. it is believed that this process will provide an effective way of evidencing predictable outcomes, assist in the development of improved clinical techniques, provide additional guidance and support for patients, and further clinical research in dental practice. in addition, implementation of studies to track patient satisfaction with clinical outcomes will provide advanced support in the decision making process. all adult patients treated at the campbell clinic will be approached for consent. this will be an ongoing process, to maximize sample size. treatment decisions will be continue to be made jointly by clinician and patient and will not be altered by participation in this study. patient consent will be sought, and all data will be anonymised for storage in the database.

Eligibility criteria:
inclusion criteria: 1. be a patient at the campbell clinic 2. be planning to undergo or have undergone specialist dental treatment, usually involved dental implants 3. be able to read and understand patient information sheet 4. have signed informed consent form exclusion criteria: 1. concern that patient has not understood patient information sheet (e.g. due to language /interpretation issues) 2. not willing to sign consent form 3. any medical condition/medication that might compromise implant success

Keywords: dental implants edentulous dental hygiene evidence-based dentistry
developing brain imaging analysis expertise for personalizing transcranial electric stimulation in anhedonia treatment of patients with bipolar depression

Conditions: Anhedonia

Summary: the purpose of this study is to investigate whether transcranial direct-current stimulation (tdcs) will engage reward-related brain circuitry, more specifically the uncinate fasciculus (uf) tract, which connects the orbitofrontal cortex (ofc) and nucleus accumbens (nacc) regions. also to evaluate whether the changes in the fractional anisotropy (fa) of the uf tract are associated with changes of clinical symptoms of anhedonia and finally to investigate the moderation role of simulated electric fields (efs) in an association between fa of the uf and symptoms of anhedonia.


Eligibility criteria:
inclusion criteria: * diagnosis of bipolar disorder and clinically significant anhedonia * mild symptoms of depression exclusion criteria: * substance abuse/dependence and any use of drugs (except alcohol or nicotine) in the previous month of the baseline assessment * participants with personality disorder that would interfere with study participation according to clinical judgment * previous neurological conditions (epilepsy, traumatic brain injury, stroke, etc) * any severe, life-threatening non-psychiatric medical condition * specific contraindications for tdcs (metallic plates in the head) * participants identified as acutely suicidal or severely agitated

Keywords: bipolar depression