Kornimate/medical-research-clean huggingface dataset:
rct of blt implants used for immediate vs early placement, restored with ceramic crowns on titanium bonding bases.

Conditions: Tooth Loss; Dental Implant, Single-tooth

Summary: the purpose of this study is to assess the outcome of a new bone level tapered implant when inserted either following an immediate placement protocol or an early placement approach and restored with single crowns out of two different ceramic materials adhesively cemented on a titanium bonding base.


Eligibility criteria:
inclusion criteria: subjects must require extraction and replacement of a tooth in the maxillary or mandibular anterior or premolar region with an implant reconstruction. * ≥22 years of age * patient in a good general health * adequate bone quality and quantity for one-stage implant placement * patient with physical status ps1 and ps2 (according to physical status classification system of the american society of anesthesiologists; attachment 5) * adequate bone height of at least 1mm longer than the length of the study implant * capable of providing written informed consent. * obtained informed consent from the patient and committed to the study and the required follow-up visits. exclusion criteria: * patients with a high lip line / smile line * thin mucosal biotype * anatomically not sufficient bone volume or height at implant site to achieve primary stability of the implant * pronounced esthetic expectations * lack of keratinized mucosa at implant site (\< 2mm oral and buccal) * women of childbearing potential with a positive urine pregnancy test * patients with inadequate oral hygiene or persistent intraoral infection * smokers exceeding 10 cigarettes / day, or equivalent; patients chewing tobacco * severe bruxism or clenching habits * presence a systemic disease or allergy (e.g. conditions requiring chronic routine prophylactic use of antibiotics or prolonged use of steroids, history of rheumatic heart disease, bacterial endocarditis, cardiac vascular anomalies, prosthetic joint replacements, etc.) * presence or history of receiving intravenous or subcutaneous antiresorptive agents, such as bisphosphonates * presence of mucosal diseases (e.g. erosive lichen planus) in the localized area around the study implant * patients with history of renal failure, bleeding disorders, metabolic bone disorder, uncontrolled endocrine disorders, hiv infection, leucocyte dysfunction and deficiencies, neoplastic disease requiring the use of radiation or chemotherapy, etc. * patients with alcohol or drug abuse * participation in any other clinical trial (drug or device) less that 30 days before implant insertion

Keywords: immediate implant placement delayed implant placement all-ceramic crown monolithic restoration titanium base
endodontic treatment of necrotic primary teeth with guedes pinto paste: a randomized clinical trial

Conditions: Endodontic Treatment of Primary Teeth

Summary: the maintenance of primary teeth until their exfoliation has been one of the main purposes of pediatric dentistry, are they representing the fundamental basis for proper occlusion of the permanent dentition. often, injuries or extensive dental caries reach the pulp of deciduous teeth making maintenance on these dependent endodontic treatment arc. thus, this study was to conduct a randomized clinical trial with longitudinal follow-up of two years, double blind, to compare the degree of success of endodontic treatment in primary among the most used folder, guedes pinto paste, and one calcium hydroxide and iodoform paste to control, vitapex.

after approval by the ethics committee of the patients faculty of dentistry, university of são paulo that having root canal filling of primary teeth will be invited to participate in the study. a clinical examination and prior radiographic diagnosis and also a quality of life questionnaire regarding oral health (- ecohis early childhood oral health impact scale) will be-held. the patient will be randomized to one of two groups and will be held endodontics by a blind handler. the patient will be accompanied with periods of one week, six months, 12 months and 24 months by a blinded evaluator. at the last visit of the review ecohis questionnaire will be reapplied to those responsible. the outcome will be the success or failure of endodontic treatments evaluated through permanent tooth in the arch on clinical and radiographic conditions of normality. the longevity of the treatments will be evaluated by estimating survival rates by kaplan-meier. the differences between the survival rates according to the type of proposed endodontic treatment will be analyzed using the log-rank test with a minimum significance level of 5%.

Eligibility criteria:
inclusion criteria: * primary teeth with pulp diagnosis and need endodontic treatment * patients whose guardians consent to their participation in the survey * fistula or abscess * bone rarefaction or visual diagnosis * teeth in the remaining tooth structure and location of the injury rehabilitation permit * do not have internal or external resorption involving more than one third of the root length * have no bone loss in lateral root and disruption crypt and the presence of at least half of root exclusion criteria: * health problems systemic * congenital facial deformities * facial tumors * syndromes

Keywords: endodontics deciduous teeth iodoform pastes treatment refusal
food safety educational training program to improve food safety knowledge and behaviors in cancer patients receiving treatment

Conditions: Hematopoietic and Lymphatic System Neoplasm; Malignant Solid Neoplasm

Summary: this clinical trial evaluates the impact of a food safety educational training program on food safety knowledge and behaviors in cancer patients receiving treatment. cancer treatments, such as chemotherapy, can put patients at risk for foodborne infections and despite this risk, it has been reported that patients do not receive any food safety counseling until they are already experiencing low white blood cell counts. a food safety educational training program may help cancer patients make better choices of low-risk foods and prepare foods safely.

primary objective: i. evaluate the efficacy of a food safety education intervention for cancer patients. outline: patients attend a food safety educational training program over 50 minutes on study. after completion of study intervention, patients are followed up at 5 weeks.

Eligibility criteria:
inclusion criteria: * participants must be at least 18 years of age * able to fluently read and converse in english (though it does not have to be their first language) * all participants must be diagnosed with cancer, any stage, and be receiving some form of treatment at the aforementioned facilities * informed consent must be obtained from each patient prior to participation in any aspect of the study exclusion criteria: * patients who do not meet these criteria or are not willing or are unable to give informed consent, will be excluded from this study * patients with prescribed dietary limitations or currently on neutropenic diet unrelated to this study will not be included
effects of replacing starchy vegetables and refined grains with beef on cardio-metabolic disease risk factors (s53)

Conditions: Diet Modification

Summary: the purpose of this study is to assess the effects of replacing starchy vegetables and refined grains with beef in a vegetarian diet on cardio-metabolic disease risk factors in adults in a cross-over, randomized controlled feeding trial.

the purpose of this study is to assess the effects of replacing starchy vegetables and refined grains with beef in a vegetarian diet on cardio-metabolic disease risk factors in adults in a cross-over, randomized controlled feeding trial. the hypothesis is that isocalorically replacing predominantly starchy vegetables and refined grains with 6 oz. of beef/day will enhance improvements in cardiometabolic disease risk factors, particularly atherosclerotic-promoting lipids and lipoproteins. it is also hypothesized that participant satisfaction and acceptance of a healthy eating pattern with 6 oz. of beef per day will be higher compared to without beef.

Eligibility criteria:
inclusion criteria: * male or female * 30-69 years old * bmi 25-37 kg/m2 * total cholesterol \<260 mg/dl * low-density lipoprotein cholesterol \<190 mg/dl * glucose \<110 mg/dl * systolic/diastolic blood pressure \< 140/90 * body weight stable for 3 months prior (±3 kg) * stable physical activity regimen 3 months prior * medication use stable for 6 months prior * non-smoking * not drinking more than 2 alcoholic drinks per day * non-diabetic * not lactose-intolerant * not acutely ill * non-pregnant and not lactating. * participants must be willing and able to consume the prescribed diets (lacto-ovo vegetarian and omnivorous). exclusion criteria: * \ 69 years old * bmi \ 37 kg/m2 * fasting serum total cholesterol \> 260 mg/dl * low-density lipoprotein cholesterol \>189 mg/dl * glucose \>110 mg/dl * systolic/diastolic blood pressure \> 140/90 * body weight stable for \<3 months prior (±3 kg) * stable physical activity regimen \< 3 months prior * medication use unstable for 6 months prior and using medications * smoking * drinking more than 2 alcoholic drinks per day * diabetic * have renal failure * have liver failure * have cardiovascular events (myocardial infarction or stroke) during the 6 months prior to the study * pregnant or lactating

Keywords: beef cardio-metabolic disease
a multicenter, randomized, double-blind, placebo-controlled efficacy study comparing 4 weeks of treatment with esomeprazole 20 mg qd and 40 mg qd to placebo qd in patients with heartburn and sleep disturbances associated with gastroesophageal reflux disease (gerd)

Conditions: Gastroesophageal Reflux Disease (GERD)

Summary: this study includes patients with sleep disturbances associated with gastroesophageal reflux disease (gerd) and has 3 treatment arms. patients will receive only one of the following treatment arms: esomeprazole 20 mg once daily, esomeprazole 40 mg once daily, matching placebo once daily. the relief to the sleep disturbances will be assessed.


Eligibility criteria:
inclusion criteria: * a history of heartburn or acid regurgitation for 3 months or longer or any history of erosive esophagitis. * nightime heartburn averaging at least 2 or 3 times per week and a history of sleep disturbances associated with gerd for 1 month or more. * nightime heartburn graded as moderate or severe on 3 of the last 7 days of the run-in period and sleep disturbances associated with gerd as documented in the run-in diary card on at least 3 of the last 7 days of the run-in period.. exclusion criteria: * any condition other than gerd that is either the primary cause of, or a significant contributor to the patients sleep disturbance. * shift workers who work between 12am (midnight) and 6am. * sleep medication, antihistamine, benzodiazepine, or anti-anxiety medication use that has not been stable for at least 3 months or is not expected to remain stable during the patients participation in the study. * other diseases / conditions as listed in the protocol.

Keywords: gastroesophageal reflux disease gerd esomeprazole heartburn nexium
the effect of a carbohydrate drink on cognitive function and exercise performance

Conditions: Fatigue

Summary: this study will investigate the effects of hydrothermally modified starch (superstarch) in adults. superstarch, originally developed as a drink for children with glycogen storage disease, is a slow digestible carbohydrate, maintaining blood sugar levels over extended periods. therefore, it could be beneficial to exercise and mental performance, and could possibly have fat loss effects by increasing feelings of fullness. in this study, measures will be taken in 25 men to assess mental function, appetite, and metabolism to determine the processes involved in possible fat loss.


Eligibility criteria:
inclusion criteria: * healthy, 18 to 35 year old man or woman. exclusion criteria: * smoker * pregnancy * taking part in other research. * followed a weight loss diet in the previous 6 months. * history of gastrointestinal, endocrine, cardiovascular disease or diabetes. * neurological or psychiatric condition that may cause cognitive dysfunction.
closed-loop functional spinal cord stimulation in patients with spinal cord injury

Conditions: Spinal Cord Injuries

Summary: the purpose of this experiment is to evaluate the efficacy of closed-loop functional spinal cord stimulation on walking rehabilitation in patients after spinal cord injury

the whole course will last around 12 months, during which there will be: pre-implant evaluations and standard rehabilitation (6-10 weeks), stimulator implantation and stimulation optimization (4-8 weeks), rehabilitation training with stimulation (6 months). at the end of the protocol, the study aims to make the patients walk better and faster.

Eligibility criteria:
inclusion criteria: * age 18\~70 * spinal cord injury staging(ais) a,b,c or d * level of lesion is t10 and above * distance between lesion and conus \>60mm * injured time \> 3 months * capable of participating rehabilitation program * agree to comply with all conditions of the study and to attend all required study training and visits exclusion criteria: * with obvious psychiatric disorder that cannot complete relevant questionaires * cognitive impairment * severe autonomic reflex disorder * severe muscle atrophy and joint contracture * cannot participate in spinal cord stimulation surgery or follow-up visits * life expectancy less than 12 months * abnormal blood or other physiological examinations that cannot conduct surgery, such as blood coagulation disorder or kidney/liver abnormalities * uncontrollable hypertension, heart diseases, respiratory diseases or took related medicine in last 3 months * unsuitable candidates in pi's perspective

Keywords: spinal cord stimulation closed-loop
sensitivity of antibiotics for urinary tract infections patients attending family physicians

Conditions: Urinary Tract Infections (UTIs)

Summary: this study is aiming to evaluate the sensitivity of uropathogens isolated in patients with community acquired uti with enoxacin in comparison to other antimicrobials. while secondary objective is to study the spectrum of uropathogens responsible for community acquired uti in local population

mid stream , clean catch urine specimens of patients with uncomplicated community acquired uti sent to microbiology labs by treating consultants from filter clinics for evaluation of pathogens will be utilized for sensitivity analysis. only the first positive urine culture obtained per sample will be included in the analysis to eliminate any possibility of recurrence and nosocomial infection. the polymicrobial cultures and cultures with multidrug-resistant uropathogens will not be included in the analysis. cultures with common contaminants, including coagulase-negative staphylococci and hemolytic streptococci, and cultures with candida growth will be excluded. . data points to be collected will be date of collection, computer generated lab #, age, gender,list of cultured organisms, sensitivity of organisms with antibiotics.

Eligibility criteria:
inclusion criteria: * samples from primary care clinics from patients who reports uti symptoms and in which uropathogens are isolated will be included. exclusion criteria: * samples from specialized, hospitalized or catheterized patients.

Keywords: uncomplicated uti enoxacin
plyometric training for elderly women

Conditions: Healthy

Summary: introduction: the physiological aging process induces several structural changes in the musculoskeletal system. these, in turn, result in functional changes that are reflected in the senescent dependency, determining the reduction in their quality of life. power training has been identified as ideal to mitigate the effects of aging. however, there are indications that an intervention based on the potentiation of the stretch-shortening cycle action is a better choice.

study hypotheses: the participants of the proposed intervention will increase their bone mineral density, muscle volume, functional capacity and will show some improvement in their gait, as well as in their quality of life. purposes: the main objective of this study was to propose a training model based in the potentiation of the stretch-shortening cycle action and assess its effects on selected parameters of musculoskeletal morphology, functional capacity and quality of life of elderly women.

Eligibility criteria:
inclusion criteria: * sedentary women, not using bone alteration medication physically able exclusion criteria: * attending less than 80% of the intervention sessions and not attending the final evaluation

Keywords: power training plyometric training functional capacity
identification of biomarkers of mastitis

Conditions: Breast Feeding; Mastitis; Mastitis Acute Female

Summary: breastfeeding is the optimal feeding for infants. who currently promotes breastfeeding and recommends it to be exclusive until the baby is 6 months old. breastfeeding has a positive impact on both the mother's and the infant's health and is directly associated with the decrease in diseases such as cancer, diabetes, cardiovascular disease, and inflammatory and infectious diseases. currently, in spain, only 39% of infants at 6 months are breastfed. the factors that influence the abandonment of breastfeeding are returning to work, the sensation of hypogalactia, problems to breastfeed, and breast complications, like mastitis, being the pain its main cause. recent studies have associated pain while breastfeeding with mammary gland inflammation (mastitis) caused by dysbiosis. in order to increase breastfeeding rates, it is necessary to find factors related to the progression of mastitis in breastfeeding women. in this context, the discovery of predictive biomarkers based on metabolic markers is key to act before or at the beginning of the progression of mastitis and thus reduce the rates of abandonment of breastfeeding due to pain. the present project aims to identify and validate metabolic biomarkers capable of predicting mastitis. for this purpose, a prospective observational case-control hypothesis-free study will be carried out in order to identify and validate biomarkers of mastitis in breastfeeding women. the study will be performed in two phases: the discovery of the possible biomarkers and the validation of the biomarkers. breast milk will be collected at the beginning of the study and when women present symptoms compatible with mastitis. the presence or not of mastitis will be confirmed with a milk culture. milk samples will be analyzed using non-targeted metabolomics approach. using multivariate statistical models, the potential metabolites capable of discriminating the presence of mastitis in maternal milk will be identified. later, these potential markers will be validated in independent samples.


Eligibility criteria:
inclusion criteria: * breastfeeding women with healthy full-term, singleton infants older than 1 months weeks and younger than 6 months. * provide written informed consent exclusion criteria: * immunocompromised suppressed women (i.e. hiv, following treatment with immunosuppressants or chemotherapy). * currently being treated for cancer * current infection being treated with antibiotics. * women who carry out a complete deferred breastfeeding. * women with babies presenting any syndrome, cleft lip or facial malformations. * currently tandem breastfeeding. * women who have had a premature delivery

Keywords: breastfeeding breast milk mastitis acute mastitis subacute mastitis biomarkers
does vitamin d improve glycemic control in type ii dm?

Conditions: Diabetes Mellitus; Vitamin D Deficiency

Summary: vitamin d status has been negatively associated with the presence of type ii dm and glycemic control. however, a cause-effect relationship between vitamin d deficiency and glycemic control has not been established. the investigators plan to conduct a double blind, randomized, placebo controlled trial on the effect of vitamin d supplementation on glycemic control in type ii dm.


Eligibility criteria:
inclusion criteria: * type ii diabetics living in riyadh area who consume no more than one serving of milk/day * do not take vitamin supplement * habitually have less than 10 hour of sun exposure per week * don't suffer from granulomatous conditions, liver disease, or kidney disease * don't take anticonvulsants, barbiturates, or steroids. * stable glycemic control (not more than 0.5% difference between current ha1c and a ha1c obtained 2-4 months earlier) * current ha1c between 6.5 and 8%, and current total 25 oh vitamin d level between 10-30 nmol/l.
clinical assessment of the treatment with cardiac sympathetic blockade on chronic heart failure

Conditions: Heart Failure

Summary: the purpose of this study is to evaluate the effect of cardiac sympathetic blockade on mortality, re-hospitalization rate, symptoms, quality of life, exercise tolerance, cardiac structure, systolic function, electrical activities and concentration of b - type natriuretic peptide precursor in patients with chronic heart failure.


Eligibility criteria:
inclusion criteria: * 20-70 years old * more than 3 months of chronic heart failure history or clinical symptoms of heart failure last for more than 3 months (including acute episode of chronic heart failure), chronic heart failure diagnostic criteria refer to 2012esc guidelines for the diagnosis and treatment of acute and chronic heart failure * nyha functional class iii-iv, ejection fraction ≤45% * nt-probnp\>400ng/l exclusion criteria: * first episode of acute heart failure * unrepaired valvular heart disease accompanied with hemodynamic changes * hypertrophic cardiomyopathy, pericardial disease, congenital heart disease, severe pulmonary hypertension * second-degree type 2 or worse sinoatrial or atrioventricular block without pacemaker therapy * right heart failure caused by various diseases, respiratory failure or right heart failure induced by chronic obstructive pulmonary disease * overt renal decompensation: serum creatinine\>2.1mg/dl(186umol/l) * severe hepatic dysfunction, transaminase or alkaline phosphatase \> 3 times the upper limit of normal * cerebral vascular accident in three months( cerebral infarction, cerebral embolism, cerebral hemorrhage,etc) * life expectancy shorter than 6 months * patients with a previous or present history of tumour or precancerous lesions confirmed by pathological examination * spine deformity or skin infection at puncture site * participate in any clinical drug trials in the three months * the patients who do not sign the informed consent, unable or unwilling to comply with the requirements of the protocol or unsuitable for the study

Keywords: heart failure cardiac sympathetic nerve block sympathetic nervous system
lyon registry of stroke treated by thrombolysis or thrombectomy

Conditions: Ischemic Stroke

Summary: this observational study as an objective of characterizing the population of patients treated within the neurovascular unit of the pierre wertheimer hospital (hospices civils de lyon) in order to determine their phenotype (age, sex, risk factors, etc.) and its evolution over time. it also aims to assess the management of ischemic stroke (is) in the neurovascular unit of pierre wertheimer hospital. we will assess in particular the pre-hospital and hospital care times, the type of medical care (thrombolysis and / or thrombectomy) as well as the efficiency of this care (effective recanalization, outcome of patient, etc.).

all patient who has had an is with an indication of thrombolysis and / or thrombectomy, hospitalized in the neurovascular unit of pierre wertheimer hospital (hcl) since january 2013 and until december 2030 will be contacted for this study

Eligibility criteria:
inclusion criteria: * - patients over 18 years old, * hospitalization in the neurovascular unit of the pierre wertheimer neurological hospital (hospices civils de lyon), * ischemic stroke treated by thrombolysis and / or mechanical thrombectomy. exclusion criteria: * - opposition to this research.

Keywords: ischemic stroke revascularisation therapy registry