Kornimate/medical-research-clean huggingface dataset:
computer-delivered psychosocial intervention for adolescent substance use disorders

Conditions: Substance-Related Disorders; Alcohol-Related Disorders; Marijuana Abuse

Summary: the purpose of this study is to develop and evaluate the acceptability and preliminary efficacy of a web-based, skills training program for adolescents with substance use disorders.

substance use among youth remains a major public health problem. about half of all 12th graders have tried an illicit drug and over 72% of this same age group have used alcohol. rates of abuse of prescription opioids among youth are estimated to have increased about 542% in the past decade. although effective substance abuse treatment programs for youth exist, they are currently of limited reach. only 1 in 10 adolescents who need substance abuse treatment receive any care. an interactive, computer-delivered psychosocial (skills-training) intervention has the potential to address these challenges, as it allows for complex interventions to be delivered at a low cost, without increasing demands on staff time or training needs. it may also be highly acceptable to youth and enable widespread dissemination of science-based treatment in a manner that ensures fidelity. in this project, we plan to develop and evaluate the acceptability and preliminary efficacy of a web-based, skills training program for adolescents with substance use disorders. the content of this program will be based in a model of psychosocial substance abuse treatment for youth that has been shown to be effective in prior scientific research. it will be provided via an interactive, delivery system that employs informational technologies that are effective in promoting relevant knowledge and skills. adolescents in substance abuse treatment will help shape the development of this program. to our knowledge, the planned program will be the first interactive program to provide comprehensive, psychosocial substance abuse treatment to adolescents via computer-based technology. this research will contribute new information relevant to increasing the delivery of science-based psychosocial treatment to adolescents with substance use disorders in a manner that is cost-effective and which may promote the adoption of effective treatment.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of non-nicotine alcohol or drug use disorder * english speaking * parental consent to participate for adolescents under the age of 18. exclusion criteria: * clinical diagnosis of psychiatric disorders that require intensive level of services, such as active psychosis, active mania or active suicidality * plan to move out of the area within the next 3 months * insufficient ability to understand and provide informed consent/assent to participate * lack sufficient ability to use english to participate in the consent/assent process, the interventions or assessments

Keywords: substance abuse treatment adolescents substance-related disorders alcohol-related disorders marijuana abuse
vaginal estrogen for the treatment of faecal incontinence in women

Conditions: Fecal Incontinence

Summary: this study will address the following questions: * does the use of oestrogen inserted vaginally with an applicator, help with the symptoms of faecal (bowel) incontinence in women who are past the age of menopause? * do women find it easy to use? * is the treatment safe for the womb lining? * is there any systemic absorption of the treatment?

faecal incontinence affects about 5% of women, the most common cause is often cited by women as obstetric trauma. however in clinical practice many women report that their symptoms of faecal incontinence begin around the same time as menopause. a community survey examining the prevalence of faecal incontinence in menopausal women is in progress. if a correlation is found between the onset of menopause and the development of faecal incontinence, further investigation of effective treatment will be indicated. the investigators want to investigate whether vaginally administered oestradiol can alleviate or improve symptoms in women who have faecal incontinence after the menopause. this is a pilot study.

Eligibility criteria:
inclusion criteria: * post menopausal women with faecal incontinence exclusion criteria: * no hormone replacement therapy (hrt) for at least 8 weeks prior to screening * diabetes mellitus * neurological disorder * terminal illness * current treatment for breast cancer * unable to give informed consent

Keywords: oestradiol, faecal incontinence, post menopausal post menopausal women with faecal incontinence
comparison of self-adhering mesh and conventional mesh in inguinal hernia repair.

Conditions: Inguinal Hernia

Summary: inguinal hernia repair coincides with a high rate of postoperative pain, extending to over a year in 10-20% of patients. although this is of major concern, early postoperative pain also has an important impact on patients and their ability to regain normal work and activities. since inguinal hernia repair is the most frequently performed operation worldwide, a small reduction in loss of workdays can already have significant impact on financial issues. as for the origin of the pain, it might be the result of local inflammation caused by the mesh material, but also by nerve entrapment due to fixation techniques. the development of a new mesh which enables sutureless fixation, cousin biotech® adhesix™, may overcome pain related to fixation techniques used in the open hernia repair procedure according to lichtenstein. furthermore, the cousin biotech® adhesix™ mesh has already been in use in our institutions and surgeons familiarized themselves with the application. the investigators would like to conduct a multicentre randomised controlled clinical trial to compare the difference in early postoperative pain after unilateral primary inguinal hernia repair in males. the procedures will be performed in day surgery. early postoperative pain is defined as the pain during the first month, with a special interest in the first two weeks. in addition, the investigators want to measure the possible benefit in terms of time to return to work, daily activities, quality of life, operation length, complications and long term postoperative pain.


Eligibility criteria:
inclusion criteria: * male * primary, unilateral inguinal hernia * age ≥18 years * social status: professionally employed * asa-score i-iii * signed informed consent * elective surgery exclusion criteria: * female * bilateral and/or recurrent inguinal hernia * femoral or scrotal hernia * vasectomy * social status: unemployed * chronic use of pain medication * symptomatic acute hernia (i.e. bowel obstruction, incarceration, strangulation, peritonitis or perforation of bowel contents) * asa-score iv or above * incapacitated adult or no signed informed consent * patient is unable to speak dutch

Keywords: inguinal hernia postoperative pain surgical mesh
long-term follow-up of patients treated with miltenyi cell and gene therapies

Conditions: Melanoma Stage III; B-cell Non Hodgkin Lymphoma; Pediatric ALL; Childhood Non-Hodgkin Lymphoma; Acute Lymphatic Leukemia; Chronic Lymphatic Leukemia; Melanoma Stage IV

Summary: the goal of this long-term follow-up trial is to assess long-term safety and efficacy of miltenyi car t treatment.

the focus in this trial is on the occurrence of any late adverse reactions (ar), serious adverse events (sae), serious adverse reactions (sar) and adverse events of special interest (aesi), i.e. relapse or progression of the underlying disease, life-threatening infections, death due to any case, new and secondary malignancies, lymphocyte counts, detection of the transgene of the car t cells, detection of replication-competent lentivirus (rcl), developmental tracking in pediatric patients and furthermore, assessment of the primary status of disease progression and overall survival.

Eligibility criteria:
inclusion criteria: * patient underwent treatment with a miltenyi car t cell therapy in one of the parent trials at least 12 months prior to enrollment in long-term follow-up. * patient has provided informed consent prior to enrollment. exclusion criteria: * no exclusion criteria
the effects of cervical mobilization

Conditions: Stroke; Ischemic Stroke; Chronic Stroke

Summary: the aim of this study is to examine the effects of cervical mobilization on balance and gait parameters in stroke individuals. twenty-four stroke individuals aged 30-65 years, with a mini mental test score of 24 and above, and with a maximum score of 3 according to the modified rankin scale, were included in this study. individuals were randomly divided into 2 groups as study (bobath approach and cervical mobilization n=12) and control group (bobath approach n=12). demographic data, gait parameters, balance parameters and craniovertebral angle values of individuals were evaluated with clinical data evaluation form, spatio-temporal gait analysis (legsystm), portable computerized kinesthetic balance device (sportkat 550) and photometer, respectivelythe evaluations were performed 2 times before and after the treatment.

the aim of this study is to examine the effects of cervical mobilization on balance and gait parameters in stroke individuals. twenty-four stroke individuals aged 30-65 years, with a mini mental test score of 24 and above, and with a maximum score of 3 according to the modified rankin scale, were included in this study. individuals were randomly divided into 2 groups as study (bobath approach and cervical mobilization n=12) and control group (bobath approach n=12). demographic data, gait parameters, balance parameters and craniovertebral angle values of individuals were evaluated with clinical data evaluation form, spatio-temporal gait analysis (legsystm), portable computerized kinesthetic balance device (sportkat 550) and photometer, respectivelythe evaluations were performed 2 times before and after the treatment. in addition to the 1 hour bobath treatment, the study group received 15 minutes of cervical region joint and soft tissue mobilizations 3 times per week along 4 weeks. the control group was treated with bobath 3 days per week along 4 weeks and each session was 75 minutes.

Eligibility criteria:
inclusion criteria: individuals diagnosed with stroke beetwen 30-70 ages had hemiparetik lezion exclusion criteria: having previously diagnosed orthopedic diseases related to the spine * acute or chronic infections (including hiv) * serious pathologies (such as cancer, spondylolisthesis, rheumatoid arthritis or ankylosing spondylitis) * have a history of whiplash or cervical surgery * having diseases that cause balance weakness (spinal cord damage, cerebellar ataxia, parkinson's disease) * having another neurological disease * having a vision problem * receiving another treatment that will affect balance and walking * having a vision problem * receiving another treatment that will affect balance and walking

Keywords: cervical mobilization head posture gait parameters balance stroke
impact of local anesthesia on postbronchoscopy fever: a randomised controlled study

Conditions: Postoperative Complications

Summary: impact of local anesthesia on postbronchoscopy fever: a randomised controlled study

fiberoptic bronchoscopy (fob) is the essential procedures for diagnosis and treatment of respiratory diseases。 fever following fob has been frequently reported. fever is usually caused by patient discomfort and delay recovery from illness, or even worse. the reported frequency of this complication ranges from 1 to 20%. according to previous reports, postbronchoscopy fever is associated with advanced age, the presence of abnormal bronchoscopic findings,documented endobronchial obstruction, bronchoscopic intervention for malignancy, bal, bronchial brushing, endotoxin contamination during bronchoscopy, instillation of topical anesthetic through the bronchoscope, abnormal differential cell counts in the bal fluid (balf), bacterial growth in the balf culture,and the severity of bleeding. at present, guidelines recommend sedation and analgesia combined with airway surface anesthesia for fiberoptic bronchoscopy. laryngeal spray and cricothyroid anesthesia often used in clinical.cricothyroid local anesthesia has a good effect, but it is an invasive operation, this is risk factors for fever after bronchoscopy.therefore, to compare fever in the two kinds of airway anesthesia on bronchoscopy . so as to provide the local anesthesia method with little influence on the patient.

Eligibility criteria:
inclusion criteria: * asa i-iii exclusion criteria: * use of immunosuppressive agents or corticosteroids * body temperature 37.3°c during the 24 h prior to fob,intubation or mechanical ventilation * therapeutic bronchoscopy (foreign body removal, bronchial toilet, or stenting), discharge within 24 h of fob * surgical or diagnostic procedures within 24 h of fob.
pain outcomes of intra-operative iv tylenol and/or iv toradol for carpal tunnel and distal radius fracture surgeries

Conditions: Postoperative Pain; Carpal Tunnel Release; Distal Radius Fracture

Summary: the purpose of this study is to determine the efficacy of intra-operative administration of iv tylenol and/or iv toradol in minimizing post-operative pain for carpal tunnel patients and distal radius fracture patients.

the study population will include patients presenting for surgery with carpal tunnel syndrome as well as surgical treatment of distal radius fracture. patients will be treated intra-operatively with either iv tylenol, iv toradol, both, or neither. all patients will receive the standard post-operative prescriptions for pain management. daily pain surveys scoring pain from 0-10 will be distributed to the subjects to be filled out over the course of 10 days prior to first post-operative visit, usually 10-14 days later. number of pain pills used before the first post-operative visit will also be measured. we hypothesize that the effects of intra-operative administration of iv tylenol and/or iv toradol will have a significant effect on decreasing post-operative pain in the first 10 days following distal radius fracture surgeries, with a significant difference in pain described as at least a 2 points on a 0-10 pain scale. we also hypothesize that intra-operative administration of iv tylenol and/or iv toradol will not have such significant effect on decreasing post-operative pain for carpal tunnel release surgery. a secondary aim is to evaluate the post-operative opioid consumption of patients within these treatment groups. we hypothesize that opioid consumption will be decreased in the groups receiving iv tylenol and/or toradol for distal radius fracture surgery compared to the placebo group. we do not expect such a difference for the carpal tunnel release surgery group.

Eligibility criteria:
inclusion criteria: * carpal tunnel release surgery candidates, * distal radius fracture surgery candidates exclusion criteria: * under 18 years of age, * pregnant women, * prisoners

Keywords: carpal tunnel syndrome opioid analgesics postoperative pain iv tylenol iv toradol
work of breathing in premature infants at discharge

Conditions: Bronchopulmonary Dysplasia; Very Low Birth Weight Infant; Prematurity

Summary: the purpose of this study is to compare how premature infants who required oxygen for at least 28 days during their time in the nicu (neonatal intensive care unit) breathe at discharge compared to premature infants who did not require oxygen for at least 28 days during their time in the nicu.

work of breathing tests will be performed on premature infants who required oxygen for at least 28 days during their time in nicu. these same work of breathing tests will be performed in another group of premature infants who did not require oxygen for at least 28 days during their time in the nicu. the two groups will be compared.

Eligibility criteria:
inclusion criteria: * infants born at greater than 26 weeks gestation, weighing less than 1500 grams at birth. * infants with diagnosis of bpd and without diagnosis of bpd exclusion criteria: * infants with skeletal, neuromuscular, or abdominal surgical disorders that affect the accuracy of work of breathing measurements will be excluded.
dl-3-n-butylphthalide and cerebrolysin treatment in acute ischemic stroke

Conditions: Acute Cerebral Stroke Within 12 Hours for the First Time

Summary: the investigators conducted a randomized, double-blind, trial enrolled 60 patients within 12 hours of acute ischemic stroke (ais) in china. patients were randomly assigned to receive a 10-day infusion of dl-3-n-butylphthalide (nbp) or cerebrolysin, or placebo. national institutes of health stroke scale (nihss) and barthel index (bi) were used to evaluate the efficacy in the patients with ais at 11-day and 21-day after therapy. adverse events were also analyzed among the three groups.


Eligibility criteria:
inclusion criteria: * acute ischemic stroke within 12 hours for the first time before entry into the study * national institutes of health stroke scale (nihss) score between 6 and 25 exclusion criteria: * with lacunar infarction * with cerebral hemorrhagic infarction * with epilepsy or epileptic persons * with history of neurological diseases * with myocardial infarction, * with renal and hepatic abnormalities * with metabolic diseases * with contraindications to antiplatelet treatments

Keywords: acute ischemic stroke dl-3-n-butylphthalide cerebrolysin
long-term assessment of quality of life and effectiveness of onabotulinumtoxina injections in provoked vestibulodynia

Conditions: Vestibulodynia

Summary: the study aims to assess and compare the pain in women suffering from provoked vestibulodynia, before treatment with botulinum injections, 3 months after treatment and 18 months after treatment.


Eligibility criteria:
inclusion criteria: * vestibulodynia rated b2 according to 2003 international society for the study of vulvovaginal disease (issvd) classification * patients previously treated no later than18 months ago for provoked vestibulodynia with botulinum toxin injections, in the university hospital of besançon. exclusion criteria: * major psychologic disorders.

Keywords: quality of life botulinum toxin provoked vulvodynia
comparing portal vein assessment by intraoperative doppler and transesophageal echocardiography

Conditions: Chronic Liver Disease

Summary: liver transplantation is usually associated with hemodynamic instability. tee allows for a real time monitoring of cardiac structures and has become a standard of care for liver transplant patients. society of cardiovascular anaesthesia and american society of anaesthesiologists recommends use of tee in non-cardiac surgery patients with hemodynamic instability. also, society for advancement of transplant anaesthesia (sata) has suggested that tee usage in cases of liver transplant is safe, effective and improves outcomes. tee can also provide vital information relating to non-cardiac structures including liver, spleen, kidneys, portal vein, hepatic vein and other major vessels. as of now standard protocol is to do the transabdominal doppler for the assessment of portal vein after the liver graft implantation. hence, the aim of our study is to compare the transesophageal echocardiography and transabdominal doppler for assessing portal vein in living donor liver transplantation.

data from all patients who underwent live donor liver transplant surgery at institute of liver and biliary sciences, new delhi and in whom tee probe was inserted will be collected and analysed.

Eligibility criteria:
inclusion criteria: * all patients who have undergone live donor liver transplant, age \> 18 years exclusion criteria: * required data is not available
evaluation of the use of multimedia to enhance patient and family understanding

Conditions: The Role of Multimedia on Retention and Comprehension of Key Concepts for Surgical Options in Newly Diagnosed Breast Cancer Patients.

Summary: this study will investigate the potential impact of arts-informed, technology-based patient education material, and specifically, the role of multimedia imagery on patient comprehension, perceived satisfaction, anxiety levels, and informed decision-making.

based on an inter-professional approach to support a new role in patient care, this research addresses both literacy and health literacy issues within the context of current challenges to healthcare delivery and associated fragmentation in continuity of care. patient education is a key component in the delivery of comprehensive care and it is the potential for on-line patient education that provides the basis for research.

Eligibility criteria:
inclusion criteria: the following inclusion criteria will be used: participants must be: 1. newly diagnosed breast cancer patients 2. a minimum age of 18 years or older 3. able to read and write in english and/or french 4. have a confirmed diagnosis of any of the following: 1. infiltrating ductal carcinoma 2. ductal carcinoma in situ (grade iii) 3. lobular carcinoma in situ (grade iii) 4. infiltrating lobular carcinoma 5. have access to, and the ability to use, a computer exclusion criteria: * the following criteria will be reasons for exclusion from the study: 1. the participant has a serious psychiatric or cognitive impairment that would prevent the patient from completing the study requirements. 2. the participant has a previous history of breast cancer

Keywords: partnered surgical decision-making impact of multimedia-based teaching patient education understanding and retention by patients
endoscopic etep versus open rives-stoppa

Conditions: Hernia, Ventral; Rectus Diastasis

Summary: observational cohort study (partially retrospective, partially prospective) comparing the endoscopic extended totally extraperitoneal prosthesis (etep) repair for midline abdominal hernias to open rives-stoppa repair (control).

see included study protocol. included patients will be registered to the european hernia society (ehs) registry.

Eligibility criteria:
inclusion criteria: group 1 (etep): * participants who underwent an etep procedure in the investigators' center * preoperative existence of one or more midline abdominal wall hernias * preoperative existence of rectus abdominis diastasis group 2 (rives-stoppa, control group): - participants who underwent an open rives-stoppa (midline repair with sublay mesh) in the investigators' center exclusion criteria: group 1 (etep): * preoperative absence of midline abdominal wall hernias * preoperative absence of rectus abdominis diastasis * intraoperative performance of transverse abdominis release (tar) * intraoperative inguinal hernia repair group 2 (rives-stoppa, control group): * intraoperative performance of transverse abdominis release (tar) * intraoperative performance of anterior component separation * intraoperative inguinal hernia repair

Keywords: etep retromuscular minimally invasive endoscopic hernia rectus diastasis rives-stoppa
comparison of acute effect of different manual techniques on muscle fascia stiffness

Conditions: Manual Lymphatic Drainage; Swedish Massage; Muscle Fascia Stiffness

Summary: there are studies investigating the effect of different massage methods on muscle fascia stiffness but the results do not support each other. in addition, there is no study to investigate the effect of mld on muscle fascia stiffness. the aim of this study is to determine the acute effect of mld and classical (swedish) massage (km) on muscle fascia stiffness after exercise.


Eligibility criteria:
inclusion criteria: * being health and woman * no systemic problem preventing exercise * having sufficient level of perception to perceive commands * bmi≤25 exclusion criteria: * having a history of injury and surgery through the quadriceps femoris muscle in the last three months * having a disease that will affect myofascial structure features * having a disease that will affect normal body temperature * chronic pain in quadriceps femoris muscle that has been going on for the last three months.

Keywords: mld, massage, fascia, stiffness