Kornimate/medical-research-clean huggingface dataset:
bleeding frequency under anticoagulant treatment in pulmonary hypertension

Conditions: Pulmonary Arterial Hypertension

Summary: pulmonary hypertension (pht) patients often receive long term oral anticoagulants. if the indication is strong, in the secondary chronic thrombo-embolism pulmonary hypertension (cte-pht) prevention, the frequent prescription (50 to 90% of patients) contrasts with their low level of proof in the pht. last but not least, anticoagulants are known to be the principal cause of iatrogenic hospitalization (major bleeding). in this study, patients are all followed during one year, to determine the annual frequency of major bleedings (according to the international society on thrombosis and haemostasis (isth) international definition). each event notified is validated by an independent committee for clinical events.

pulmonary hypertension (pht) patients often receive long term oral anticoagulants. if the indication is strong, in the secondary chronic thrombo-embolism pulmonary hypertension (cte-pht) prevention, the frequent prescription (50 to 90% of patients) contrasts with their low level of proof in the pht. last but not least, anticoagulants are known to be the principal cause of iatrogenic hospitalization (bleeding). the only one study scaling the tolerance of anticoagulants for this population found major hemorrhagic levels discording with the clinical practice : really high for connectives associated to pulmonary arterial hypertension (paht), and lower in "simple" pulmonary embolism in cte-pht. these discoveries could belong to methodological failures of this study: a retrospective, monocentric one, without adjudication of events by an independent committee. furthermore, there were no information about the existence of a validated indication for anticoagulant treatments. patients are all followed during one year, to determine the annual frequency of major bleedings (according to the international society on thrombosis and haemostasis (isth) international definition). each event notified is validated by an independent committee for clinical events.

Eligibility criteria:
inclusion criteria: * patient insured or entitled to a social security scheme; * patient with confirmed pulmonary hypertension; * pulmonary hypertension among the following etiological diagnosis: idiopathic pah, pah associated with appetite suppressants, pah associated with connective, or chronic thrombo-embolism pulmonary hypertension; * patients receiving oral anticoagulants. exclusion criteria: * impossible following; * bleeding at baseline; * life expectancy of less than 3 months; * pulmonary hypertension in group 2, group 3 (in the absence of associated pulmonary embolism) and group 5 (in the absence of associated pulmonary embolism).

Keywords: pulmonary arterial hypertension oral anticoagulants major bleedings
the effect of tps on cognitive functions in older adults with mci

Conditions: Mild Cognitive Impairment

Summary: the goal of this randomized controlled trial is to learn if transcranial pulse stimulation (tps) can improve cognitive functions in older adults with mild cognitive impairment (mci). the study will also assess the safety of tps. the main questions it aims to answer is: does tps improve cognitive functions such as global cognition, attention, memory, and executive function? researchers will compare tps to a sham control to evaluate the efficacy and safety of tps in improving cognitive functions in older adults with mci. participants will: be randomly assigned to receive either tps or a sham intervention undergo 6 sessions of tps or sham intervention over a 2-week period visit the clinic for cognitive assessments at 4 different time points (baseline, immediately post-intervention, 1-month follow-up, and 3-month follow-up) complete questionnaires and undergo standardized neurocognitive tests, and/or mri scans, and/or eeg assessments the study aims to provide insights into the potential therapeutic role of tps in enhancing cognitive functions among older adults with mild cognitive impairment.


Eligibility criteria:
eligibility criteria inclusion criteria: community-dwelling older adults aged 55 and above diagnosed with mild cognitive impairment (mci), classified based on: subjective reporting of memory deficits a score of 19-24 on the hong kong version of the montreal cognitive assessment (hk-moca) a score greater than 2 standard deviations on the lawton instrumental activities of daily living (iadl) scale a score of 1 point or less on the ad8 questionnaire right-handedness ability to cooperate with assessment and intervention, without significant communicative impairments absence of depression or anxiety, scoring less than 8 on both the hamilton depression scale (ham-d) and the hamilton anxiety rating scale (ham-a) exclusion criteria: current or history of dementia or other psychiatric diseases score greater than or equal to 5 on the hachinski ischemic scale (his) for identifying possible vascular-related causes current or history of alcohol or drug abuse on medication within the last 2 weeks that may affect cognitive functions report having any present neurological or psychiatric condition besides mci report having hemophilia, other blood clotting disorders, or medication that may cause these conditions
investigation of wearing compliance of spectacles for myopia control

Conditions: Myopia

Summary: the goal of this observational study is to compare the wearing patterns of spectacles prescribed for myopia control in juvenile wearers.

this unmasked, multi-center, observational study will evaluate the wearing patterns of established (use of ≥3 months) juvenile spectacles wearers. wearing pattern will be measured via the use of temperature sensors fitted to the sides of the participant's spectacles. data from the final week of the 1-month study will be used for analysis to minimize 'unusual' wear patterns which may occur early in the study.

Eligibility criteria:
inclusion criteria: 1. they are aged between six and 15 years old. 2. their parent or guardian understands the rights of the subject and are willing to sign a statement of informed consent. 3. they understand the study at a level appropriate for their age and are willing to sign a statement of assent. 4. they and their parents or guardians are willing and able to follow the protocol. 5. they currently use spectacle lenses for myopia control and have done so for at least three months. 6. they agree not to participate in other clinical research for the duration of this study. exclusion criteria: 1. they have an unusual ophthalmic history, which in the opinion of the site investigator or principal investigator might impact on the successful conduct of the study. 2. they are amblyopic.
nanofat on wound healing and scar formation

Conditions: Scars; Delayed Wound Healing; Hypertrophic Scar; Post Inflammatory Hyperpigmentation; Donor Site Complication

Summary: this study will evaluate the effectiveness and safety of intradermal injection of nanofat on wound healing and scar formation.

in this monocentric, randomized, controlled, double-blinded prospective interventional study, twenty patients will be included. each patient will be his/her own control. patients undergoing diepflap breast reconstruction will be included in this study. during the surgery, the abdominal incision will be divided in two equal sides with the umbilicus as midline reference. the sides will be randomized in a treatment side and control side. the treatment side will receive intradermal nanofat injections after the subcutaneous and right before the intradermal sutures. the patient and investigators will be blinded for the treatment protocol. the effects on wound healing, adverse events, scar formation and pigmentation will be evaluated up to one year after the surgery.

Eligibility criteria:
inclusion criteria: - scheduled for diep-flap breast reconstruction surgery at our department exclusion criteria: * smokers * use of cortisone or other immunsuppressants * diabetes mellitus type 1 or 2 * age * connective tissue disease

Keywords: adipose derived stem cells stromal vascular fraction wound healing scar formation donor site morbidity nanofat
poem- peroral endoscopic myotomy for esophageal motility disorders

Conditions: Achalasia

Summary: poem has recently described as an alternative treatment for achalasia in humans. in this procedure the esophageal sphincter is incised through a submucosal tunnel in the esophagus. in this study we aim to perform poem on achalasia patients.


Eligibility criteria:
inclusion criteria: * patients with achalasia whom are candidates for heller myotomy exclusion criteria: * perforation of les during dilatation * pregnant women * mentally ill patients
heat and acupuncture randomised controlled trial to manage osteoarthritis of the knee

Conditions: Osteoarthritis, Knee

Summary: knee osteoarthritis (koa) is one of the largest and fast-growing causes of pain, impaired mobility, and poor quality of life in the elderly worldwide. despite a significant increase in traditional chinese medicine (tcm) utilisation, in particular acupuncture, as first or second-line treatment among local koa patients, there exists a lack of high-quality evidence on its efficacy and local practice guidelines for tcm use in koa tailored to our specific population demographic. harmoknee trial aims to address these gaps by evaluating the short and medium-term clinical and cost-effectiveness of tcm acupuncture with far-infrared heat therapy in addition to standard care, compared to standard care alone. through a robust process and economic evaluation, the investigators aim to inform evidence-based practice for koa patients in singapore to facilitate the large-scale implementation of a comprehensive and holistic model of care which harmonises elements from western medicine and tcm. the investigators hypothesize that acupuncture with heat therapy as an adjunct to standard care is clinically more effective than standard care alone. this will be a multi-centre pragmatic, parallel-arm, single-blinded, effectiveness-implementation hybrid randomised control trial. koa patients will be randomised to either the control arm (standard care only) or intervention arm (biweekly sessions of acupuncture with heat therapy over 6 weeks, in addition to standard care). a mixed-method approach through an embedded process evaluation will facilitate large scale implementation. an economic evaluation will be performed to evaluate financial sustainability


Eligibility criteria:
inclusion criteria: 1. 45 to 99 years old 2. independent community mobilizers with or without walking aids 3. conversant in english or chinese 4. nice clinical criteria for oa knee exclusion criteria: 1. alternative diagnosis to koa e.g., referred pain from the spine or hip 2. other forms of arthritis eg., inflammatory, post-traumatic 3. inability to comply with study protocol e.g., cognitive impairment 4. previous knee arthroplasty 5. wheelchair-bound patients 6. medical conditions that will medically interfere with study involvement e.g., decompensated heart failure, stroke, end-stage renal failure 7. allergies to metal (needles)
techcare: mobile-assessment and therapy for psychosis: an intervention for clients within the early intervention service

Conditions: Feasibility Studies

Summary: the aim of the project is to conduct a feasibility study of the mobile phone application "techcare" for individuals with psychosis in the north west of england.

this feasibility study will follow the nihr guidance on feasibility study design (nihr, 2014) and will consist of both qualitative and quantitative components. the study will run across three strands as follows 1) qualitative work \& systematic review 2) test run and intervention refinement 3) feasibility trial.

Eligibility criteria:
inclusion criteria: * each client must be accepted into the psychosis group of the lancashire early intervention service. * ages 18 - 35 years * medication stable for previous two months * clients must be currently stable-the lancashire early intervention team uses a traffic light system to indicate current symptomatology and risks of each client. for this study we will use only clients with a green light, signifying that they are currently stable. * a score of 3 or more on positive symptoms on the panss * minimum score of 1 on the calgary depression scale. exclusion criteria: * drug induced psychosis * an acquired brain injury or learning disability * clients who are undergoing assessment, not formally diagnosed and accepted into the service. * lacking capacity for informed consent. * ultra high risk of developing psychosis group (i.e. prodromal, not first episode)
survival outcomes in metastatic prostate cancer in the brazilian population - analysis of individual characteristics and treatment modalities in different national health institutions.

Conditions: Prostatic Neoplasms, Castration-Resistant

Summary: survival outcomes in metastatic prostate cancer in the population brazilian - analysis of individual characteristics and modalities of treatment in different national health institutions


Eligibility criteria:
inclusion criteria: * diagnosis of castration-resistant metastatic prostate cancer diagnosed in the period between january 2014 and december 2017. exclusion criteria: * diagnosis of localized or locally advanced or metastatic disease sensitive to castration; * patients with medical records filled with incomplete data that make it impossible to evaluate the treatment received.

Keywords: prostatic neoplasms
targeting inflammation in acute coronary syndrome using colchicine

Conditions: Acute Coronary Syndrome

Summary: the purpose of this study is to evaluate the effect of colchicine on high sensitivity c-reactive protein (hs-crp), a blood marker to measure inflammation, in patients with acute coronary syndromes.


Eligibility criteria:
inclusion criteria: * all patients with a diagnosis of acute coronary syndrome who are \> 18 years old and who do not have any contraindication to colchicine. exclusion criteria: * contraindication to colchicine including any of the following: * hypersensitivity to colchicine * severe renal, hepatic or gastrointestinal disorder * blood dyscrasias (myelodysplasia cytopenias etc) * concurrent use of moderate-strong cyp3a4 inhibitors (a complete list is appended in the full protocol) * known severe liver disease and/or elevated transaminases \> 1.5x the upper limit of normal * estimated gfr \< 50 ml/min * pregnant or lactating women or women not protected by a reliable contraception method * current treatment with colchicine at enrollment * active infection or systemic inflammation eg active rheumatoid arthritis
mri-based 3d hip labrum and cartilage morphology in patients with hip deformities compared to asymptomatic volunteers

Conditions: Hip Disease

Summary: in this study, the investigators seek to describe the normal 3d hip joint morphology in asymptomatic volunteers and compare it to various hip joint deformities. asymptomatic volunteers will be asked to undergo a non-contrast mri of the hip at 3 tesla, utilizing a high-resolution morphologic 3d sequence (3d t2 dess) that enables the segmentation of labrum and cartilage. 3d morphological parameters of the asymptomatic group will subsequently be compared with the 3d morphological parameters of patients with hip deformities, which were collected as part of a previous retrospective study.

hip deformities can cause hip pain and early onset osteoarthritis in young individuals. correcting these deformities typically involves planning with x-rays and mri images, which offer a limited view of the hip joint's 3d structure. a comprehensive 3d analysis of hip structures, including cartilage, and labrum, would enhance diagnosis and surgery planning. however, 3d hip morphology hasn't been adequately described for distinguishing deformities. the aim of this study is to describe normal 3d hip joint morphology in healthy participants and compare it to various hip joint deformities (dysplasia, acetabular protrusion, retroversion, deep hip, and cam deformity). asymptomatic volunteers will undergo a non-contrast mri of the hip at 3 tesla using high-resolution morphologic 3d sequence (3d t2 dess), which allows segmentation of labrum and cartilage. the 3d morphological parameters of the asymptomatic group will then be compared with those of patients with hip deformities, data sourced from a retrospective study that included 100 patients from the outpatient clinic. these patients underwent direct mr arthrography at 3 tesla in accordance with the institutional routine protocol at the department of diagnostic, interventional, and pediatric radiology at inselspital.

Eligibility criteria:
inclusion criteria: * age \> 18 years. * signed an informed consent form. * history free of significant hip pain, with no history of juvenile hip disease, traumatic injuries, inflammatory conditions, or tumors affecting the hip. * normal clinical examination of the hip. exclusion criteria: individuals who are not considered suitable for mri (magnetic resonance imaging) for the following reasons: * potential pregnancy * presence of metal fragments in the eye or elsewhere in the body * presence of implants and metallic foreign bodies, such as a pacemaker, heart valve, cerebrospinal fluid shunt, insulin pump, nerve stimulator, or cochlear implant * claustrophobia

Keywords: hip dysplasia acetabular protrusion deep hip acetabular retroversion
translocator protein pet/ct in various tspo-related disease

Conditions: Neuroinflammation; Stroke; Neurodegenerative Diseases

Summary: to evaluate the potential usefulness of 18f-dpa714/fdpa positron emission tomography/computed tomography (pet/ct) for the diagnosis of primary and metastatic lesions in various tspo-related disease patients.

subjects with various tau-related disease patients underwent 18f-dpa714/fdpa pet/ct either for an initial assessment or for recurrence detection. lesions uptake was quantified by the maximum standard uptake value (suvmax). the sensitivity, specificity, positive predictive value (ppv), negative predictive value (npv) and accuracy of 18f-dpa714/fdpa pet/ct were calculated.

Eligibility criteria:
inclusion criteria: - (i) adult patients (aged 18 years or order); (ii) patients with suspected or new diagnosed or previously treated malignant tumors (supporting evidence may include mri, ct, tumor markers and pathology report); (iii) patients who had scheduled tspo pet/ct scan; (iv) patients who were able to provide informed consent (signed by participant, parent or legal representative) and assent according to the guidelines of the clinical research ethics committee. exclusion criteria: - (i) patients with non-malignant lesions; (ii) patients with pregnancy; (iii) the inability or unwillingness of the research participant, parent or legal representative to provide written informed consent.

Keywords: pet/ct mri tspo
coronary revascularization in patients with dialysis in china

Conditions: Coronary Artery Disease; Dialysis; Intervention

Summary: china patients in end stage renal disease receiving maintenance dialysis have a high risk of cardiovascular disease (cvd), with a prevalence of 45.5% approximately, and coronary artery disease (cad) has been identified as the most common one. it remains unclear that what their treatment status is and whether this group of patients can benefit from revascularization in china. the investigators plan to recruit around 30 hospitals from 7 regions as study centers, which represent different levels of economic development in mainland china. the detailed information includes demographics, medical history, coronary angiogram, in-hospital treatment and procedures, short-term and long-term outcomes. the aim of the study is to provide the real world knowledge about current status of coronary revascularization and prognosis in patients with cad and dialysis.


Eligibility criteria:
inclusion criteria: * aged 18 or above and 85 or below. * receives peritoneal dialysis or hemodialysis more than 1-time weekly and for more than 3 months. * diagnosed with coronary artery disease, including stemi, nst-acd, stable coronary artery disease. exclusion criteria: * pregnancy or lactation. * can't be cooperative because of a mental illness or other reasons. * malignant tumor or severe hepatic disease. * life expectancy is less than 1 year.

Keywords: dialysis coronary artery disease revascularization optimal medical therapy prognosis
the burden of (neuro)cysticercosis among people living with hiv in rural tanzania

Conditions: Neurocysticercosis; HIV/AIDS

Summary: this study aims to compare the burden of neurocysticercosis among people living with hiv to people not infected with hiv.

people living with hiv and matched hiv negative controls will be tested serologically for cysticercosis, examined neurologically and will undergo ct scanning to determine the prevalence and presentation of ncc. furthermore, the immune system response in hiv patients with taenia solium neurocysticercosis will be assessed.

Eligibility criteria:
inclusion criteria: * patients who consent to participate in the study and testing. * patients of age 14 years and above * patient living inside the study catchment area * hiv-positive patients * patient suspected of taeniasis or cysticercosis/neurocysticercosis exclusion criteria: * patients with opportunistic infections. * study participants taking anthelminthic drugs pzq and alb or have received them within the previous 12 months. * pregnant women * patients that are seriously ill. * patients with epilepsy and other mental disorders that impair thoughts and emotions such as psychosis.
effects of proprioceptive activities on hand function in chronic stroke patients

Conditions: Stroke; Proprioceptive Disorders

Summary: to determine effects of proprioceptive activities on hand function in chronic stroke patients

stroke is causing the long term disability worldwide. the patient in the chronic phase of stroke may suffer from long term hand disability along with both motor and sensory dysfunction. that causes hindrance in performing the adls. as the hand is the important organ performing major functions of daily living .so the early restoration of the motor as well as sensory function is necessary. the motive of this study is to determine effects of proprioceptive activities on hand function in chronic stroke patients. total 40 chronic stroke patients will be included in the study. they will be randomly allocated in two groups by lottery method that fulfills the inclusion criteria of the study. in group a patients will be recruited and proprioceptive activities will be given to the affected hand for 3 days /week for 2 months. on the other hand in group b conventional therapy will be given for 3 days /week for 2 months. in sensory training graphesthesia and stereognosis will be checked by modified subtest of sensory integration praxis test and byl-cheney-boczai sensory discriminator test respectively. the motor task will be assessed by the wolf motor test. as a baseline treatment hot pack for 15 min will be given to both of the groups

Eligibility criteria:
inclusion criteria: * either right or left sided hemiplegic patients post stroke 6 months to 4 years * can partially open and close hand and able to elevate arm to at least 60 degrees and bend to 45-60 degree against gravity. exclusion criteria: * patient with tbi, neuromuscular degenerative diseases, diabetes, heart disease, fracture of hand ,.muscular skeletal injuries of hand or birth deformities of hand * patients having any known or diagnosed psychological condition or unable to follow the command for exercise.

Keywords: graphesthesia stereognosis stroke