Kornimate/medical-research-clean huggingface dataset:
family-clinician collaboration to improve neglect and rehabilitation outcome after stroke

Conditions: Stroke; Spatial Neglect

Summary: spatial neglect may occur in patients who have had a stroke. people with spatial neglect often pay much more attention to one side of the body while ignoring the other side, even though they have no difficulty seeing. the purpose of this study is to evaluate the impact on stroke recovery, including spatial neglect, of the family-clinician collaboration program, where a family member of a stroke survivor actively interacts with clinical staff members providing inpatient rehabilitation services to the stroke survivor.

spatial neglect (sn) frequently occurs in patients who have had a stroke. the problems caused by sn result in patients failing to attend to the space contralateral to the side of the stroke. this failure to attend to half of the patient's field may result in problems with perception, memory, action planning and navigation. these deficits hurt both the patients and their caregivers, and make it difficult for them to resume daily activities as they were before the stroke. more than half of the patients who had sn at admission still had it when discharged from an inpatient rehabilitation facility. this study examines a new behavioral treatment, where the clinician and the caregiver work together to provide better treatment. the family members will engage in frequent meetings with clinicians, set goals, learn about sn and coping strategies and have the patient to perform easy, safe treatment exercises. the study will compare this family-clinician collaboration with the inpatient treatment control. this study will compare the groups in measures of spatial neglect and independence in the patients and measures of caretaker burden and mental health in family members. participants will also report on their overall opinions of the new treatment condition.

Eligibility criteria:
inclusion criteria: * unilateral right brain stroke * functionally independent before stroke * presence of spatial neglect (moderate to severe, will be confirmed during the screening session) * ability to follow instructions and understand verbal or written english * currently living with a family member who will be enrolled into the study as well exclusion criteria: * history of progressive neurological disorder * history of a significant psychiatric disorder * living outside of 50-mile radius of kessler foundation (west orange, nj)
optimization of the core number and location for targeted prostate biopsy

Conditions: Prostate Cancer

Summary: this study aims to investigate the effect of core number and location optimization for targeted prostate biopsy on pathological accuracy.

this is a single-center prospective study. the investigators perform mri/us image fusion targeted saturation biopsy on prostate lesions with pi-rads score 4, to investigate the effect of core number and location optimization for targeted prostate biopsy on pathological accuracy.

Eligibility criteria:
inclusion criteria: 1. men more than 18 years old with clinical suspicion of prostate cancer; 2. serum psa ≤ 20 ng/ml within the previous 3 months; 3. no evidence of psa increase by noncancerous factors, such as catheterization, bladder stones, or urinary tract infection including bacterial prostatitis; 4. mpmri pi-rads v2.1 score ≥4, diameter of ≤2.5 cm； 5. able to provide written informed consent. exclusion criteria: 1. prior prostate biopsy or prostate surgery; 2. prior treatment for prostate cancer; 3. contraindication to mri (e.g. claustrophobia, pacemaker); 4. contraindication to prostate biopsy; 5. men in whom artifact would reduce the quality of the mri.
study evaluating the analgesic efficacy of capsaicin 8% patches in chronic coccygodynia.

Conditions: Coccyx Disorder; Neuropathic Pain; Coccygodynia

Summary: the primary objective is to demonstrate the analgesic effect at day 60 of 8% capsaicin patch (qutenza) for the treatment of patients with coccygodyinia.

this trial is a french, multicenter, randomized, controlled, bouble-blind and prospective study. patients enrolled will be clinically followed for 5 months. the treatment duration per subject is 1 hour (1time).

Eligibility criteria:
inclusion criteria: * \>18 years old at the pre-inclusion visit * presenting with chronic coccygodynia: pain in the coccygeal region, increased by sitting and or when rising from a sitting position and pain over the last ten days of intensity greater than or equal to four on the eleven-point numerical scale (from zero to ten) and having been present for more than 3 months. * failure of previous treatments: nsaids, pressure-relieving cushions and/or infiltration or having a contraindication to these treatments, or not wishing to receive these treatments * have never been treated with an 8% capsaicin patch for this indication * with at least one clinical sign suggestive of neuropathic pain (burning, painful cold, numbness, tingling, electric discharge, allodynia of the gluteal groove, allodynia to pressure on the coccyx) * proficiency in reading and writing the french language * be affiliated to the social security system * have signed an informed consent form * women must meet one of the following criteria at the time of inclusion: * be using adequate contraceptive measures, and have a negative pregnancy test (specify if urine or blood test) prior to receiving the first dose of trial medication; * or be post-menopausal (aged over 50 with amenorrhoea for at least 12 months after stopping all exogenous hormonal treatments) * or (if under 50) have been in amenorrhoea for at least 12 months after stopping all exogenous hormone treatments and with luteinising hormone (lh) and follicle stimulating hormone (fsh) levels corresponding to post-menopausal levels. * or have undergone irreversible surgical sterilisation by hysterectomy, bilateral oophorectomy or bilateral salpingectomy (this operation must be documented). exclusion criteria: * coccygodynia accompanied by a dermatological lesion in the intergluteal cleft (psoriasis, pilodinial cyste, wound) * patients with other major pain disorders likely to interfere with pain assessment * hypersensitivity to capsaicin or to one of the excipients * adults under legal protection (guardianship, curatorship, legal protection) * pregnant or breast-feeding women * patients who have undergone total coccygectomy
change of retinally-induced aniseikonia in patients with epiretinal membrane after vitrectomy

Conditions: Epiretinal Membranectomy

Summary: epiretinal membrane is common disease, affecting 5\~10 % incidence over 60 years old population. it reduce visual acuity, cause metamorphopsia. in the past, vitrectomy and epiretinal membranectomy was indicated in patients with visual acuity less than 20/40, but nowadays with technical improvement and surgical instrument renovation, it seems to have been changed the surgical indication. therefore, we plan to evaluate the changes of binocular visual acuity, aniseikonia in patients with epiretinal membrane.


Eligibility criteria:
inclusion criteria: * idiopathic epiretinal membrane who had impaired vision or metamorphopsia, want to undergo vitrectomy * age more than 20 years and less than 90 years old exclusion criteria: * secondary epiretinal membrane due to retinal surgery, * impaired visual acuity less than 20/40 in the normal eye(snellen chart) due to severe cataract * glaucoma patients * complication during vitrectomy (ex. retinal tear, silicone oil injection, ...) * other retinal disease except epiretinal membrane * other ocular surgery history within 3 months * intellectual problems or illiterate whom could not obtained informed consent

Keywords: epiretinal membrane, stereopsis, aniseikonia
development and testing of a new generation of diabetic footwear

Conditions: Diabetes Complications; Diabetic Neuropathies

Summary: this particular trial is looking to compare the effectiveness of two types of foot bed/ sole materials used within diabetic footwear.

diabsmart as a project aims to generate, transfer and exchange the clinical, academic and production knowledge between the partners to create a new generation of diabetic footwear through a newly developed patient assessment system. the transfer of knowledge between various sectors ensures that the need of patients is considered and transferred effectively to product development using a scientific approach. the objectives include:(1) the design and development of an integrated system of diabetic foot assessment (2) to validate the newly developed system using experimental methods (3) to develop a suitable material to meet the mechanical and clinical requirements (4) to evaluate the mechanical and clinical effectiveness of material choice in reducing the potential risk of foot complications. the numerical, experimental and mathematical analyses system will integrate all aspects of diabetic footwear including; clinical and biomechanical assessment, material choice and aesthetic design. proposed interdisciplinary, inter-sectorial approach is unique and brings together the expertise from research institutions, industry and clinics. this project while enhancing the knowledge base in diabetic assessment; will have a clear impact on new product development leading to both clinical and economic benefits. the products include a new generation of integrated smart /multi material midsoles and/or orthoses for diabetic footwear. properties of the materials will be optimised with a view to minimise/ redistribute the pressure and hence the stress on the soft tissue in the critical plantar areas of the foot. whilst significantly affecting the course of the disease, the products will aim to reduce the risk of limb loss in patients with diabetes, the most frequent cause of non-traumatic lower-limb amputations.

Eligibility criteria:
inclusion criteria: * diagnosed with diabetes by who criteria * lack of sensation to 10 g monofilament or vpt \>25 v * ability to walk independently for 10 m * no ambulatory status * no severe foot deformity like charcot foot * willingness to be assigned to randomisation of footwear * at least one palpable pedal pulse on each foot exclusion criteria: * previous ulceration or current trophic ulcers * active foot infection * alzheimer and dementia and impaired cognitive function * gross abnormality or foot deformity requiring footbed customisation * chronic kidney disease * hammer toes * previous foot surgeries
study of catheter-related infections using antibiotic-coated versus conventional catheters in children

Conditions: Infection Prevention

Summary: the primary purpose of the study is to determine if a therapeutic difference exists between central venous catheters impregnated with minocycline and rifampin and conventional catheters not impregnated with antibiotics when used in children at high risk for bloodstream infections (cabsi) after cardiac surgery.

the standard central venous catheter (cvc) is now commonly used for infants, children, and adults. the antibiotic-coated cvc is a newer cvc gaining popularity for use in adults. the food and drug administration (fda) and the center for disease control (cdc) support use of the antibiotic-coated cvc for adult patients. but the fda and cdc have not yet endorsed use of the antibiotic-coated cvc for infants and children due to lack of research on this cvc in infants and children.

Eligibility criteria:
inclusion criteria: * age \< 18 years * cardiovascular surgery patient with a case complexity warranting cvc placement longer than 3 days * study devices of appropriate size for patient use without modification * informed consent obtained prior to patient entering the operating room exclusion criteria: * age ≥ 18 years * drug allergy to minocycline, other tetracyclines, or rifampin * ventricular assist device (vad) therapy * extracorporeal membrane oxygenation (ecmo) therapy * patients undergoing cardiac transplant * any active infection or being treated for bacteremia at the time of randomization
effects of mechanical versus manual traction in the management of low back pain.

Conditions: Low Back Pain; Low Back Pain, Mechanical; Disc Degeneration; Disc Prolapse; Disc Prolapse With Radiculopathy; Lumbar Radiculopathy

Summary: this study compared the effects of mechanical and manual traction on pain, disability and lumbar spinal curvature in patients with discogenic low back pain


Eligibility criteria:
inclusion criteria: * patients with discogenic low back pain, * patients of both genders * age ranges from 20 to 60 years * nprs \> 5 exclusion criteria: * patients with non-mechanical back pain * patients with known metabolic diseases, * osteoporotic patients, * recent history of spinal trauma or surgery, * lumbar myelopathy, * cauda equine syndrome.
a new modified suture bridge technique

Conditions: Rotator Cuff Tears

Summary: we aimed to introduce a new modified suture bridge technique and report the clinical outcomes and radiological assessments of modified suture bridge technique for medium rotator cuff tears.

purpose: we aimed to introduce a new modified suture bridge technique and report the clinical outcomes and radiological assessments of modified suture bridge technique for medium rotator cuff tears. methods: we prospectively followed 50 consecutive patients with medium rotator cuff tears treated with the modified suture bridge (msb) or traditional suture bridge technique (tsb) from december 2018 and december 2019. on the basis of preoperative findings and mri performance, 26 patients underwent msb repair whereas 24 underwent tsb repair. range of shoulder motion, visual analog scale score (vas score), university of california-los angeles score (ucla score), constant-murley shoulder score (constant score), american shoulder and elbow surgeons score (ases score) were assessed. magnetic resonance imaging were performed preoperatively and at 12 months postoperatively.

Eligibility criteria:
inclusion criteria: * (1) full-thickness medium tears (1-3cm) of primary supraspinatus (ssp) tendon was identified on preoperative mri and intraoperative arthroscopy, (2) undesirable conservative treatment for 3 months, (3)completed follow-up of 12 months postoperatively and patients who adhered to the rehabilitation plan. exclusion criteria: * (1) previous shoulder surgery, (2) other pathological changes that would need to be addressed at the time of arthroscopic surgery, such as rotator cuff tear involving the subscapular (ssc) tendon，biceps tendon injury, (3) failure to follow our postoperative rehabilitation protocol and patients without regular follow-up.

Keywords: rotator cuff tear， modified suture bridge technique
investigation of factors affecting shoulder pain in stroke survivors

Conditions: Stroke

Summary: the aim of this study was to examine the factors affecting shoulder pain in stroke survivors and to determine how much the factors affect shoulder pain

the study included 62 stroke patients who got stage 3 or more from the brunnstrom upper limp stage. we assessed shoulder pain using the visual analog scale, evaluated muscle tone using the modified ashworth scale, identified myofascial trigger points by manual palpation, and measured range of motion using a universal goniometer. we employed the fugl-meyer upper extremity assessment to assess the functional status of the upper extremities. we also used the neer impingement, apprehension, acromioclavicular shear, and speed tests to evaluate the soft tissue condition.

Eligibility criteria:
inclusion criteria: * having received a diagnosis of hemiplegia following a cerebrovascular accident (cva) * having experienced a first-time stroke * having unilaterally affected, having stage 3 or above brunnstrom upper limb stage * not having any other neurological/orthopedic problems in addition to hemiplegia * not having any shoulder problems on the same side (affected side) before the stroke * not having any shoulder problems on the same side (affected side) before the stroke exclusion criteria: * having a history of shoulder injury (affected side) * neurological and orthopedic diseases other than stroke * prior stroke * bilateral involvement * non-cooperation

Keywords: functionality hemiplegic shoulder pain stroke muscle tone rehabilitation
microcirculation assessment in diabetes and metabolic syndrome

Conditions: Coronary Microvascular Dysfunction; Metabolic Syndrome; Diabetes

Summary: abnormal coronary microvascular vasodilation has been demonstrated in patients with diabetes and metabolic syndrome, but the role of insulin resistance in its pathogenesis is not clear. the aim of this study is to invasively assess coronary microcirculation and to investigate the relationship of insulin resistance with coronary microvascular dysfunction. a pressure temperature-sensor-tipped coronary wire will be advanced in coronary arteries without significant lumen reduction. thermodilution-derived coronary flow reserve (cfr) will be calculated as resting mean transit time (tmn) divided by hyperemic tmn (obtained with a 5-min i.v. infusion of adenosine 140 mg/kg/min). an index of microvascular resistance (imr) will be calculated as the distal coronary pressure at maximal hyperemia divided by the inverse of the hyperemic tmn. ffr will be calculated by the ratio of pd/pa at maximal hyperemia. insulin resistance (ir) will be assess by the homeostasis model assessment (homa) index and plasma il-6 and tnf-alpha levels will be measured in addition to routine blood examinations before the procedure.


Eligibility criteria:
inclusion criteria: * patients with stable angina or inducible myocardial ischemia * coronary arteries without high-grade epicardial stenoses (angiographic stenosis \ 0.75) exclusion criteria: * significant renal insufficiency (serum creatinine \> 1.5 mg/dl), a recent (\< 1 week) acute coronary syndrome, heart failure, severe valvular disease, or hypertrophic cardiomyopathy.
psychotherapy plus: combining cognitive behavioral therapy with tdcs

Conditions: Major Depression

Summary: the study will investigate whether cognitive behavioral psychotherapy (cbt) combined with prefrontal transcranial direct current stimulation (tdcs) is more efficacious with regard to symptom reduction in depressed patients than cbt combined with sham-tdcs or cbt alone.

brain stimulation techniques are widely seen as promising treatment alternatives for patients not responding to or tolerating psychotropic medication. in particular, transcranial direct current stimulation (tdcs) is of special interest due to its potential to be used by a large number of patients because of its comparably ease of usage and good tolerability. thus, a large number of studies investigating clinical effects of tdcs have been performed with statistically significant effects but that are of moderate clinical relevance. clinical studies have mainly focused on the prefrontal cortex (pfc) as the main stimulation target based on findings of numerous studies indicating the lateral pfc to be a key dysfunctional node within brain networks involved in the pathophysiology of depression. studies in clinical and healthy participants indicate that tdcs is capable of positively augmenting prefrontal functions that are relevant for a successful cognitive behavioral therapy. more specifically, it has been shown that tdcs is capable of improving reappraisal strategies as well as the use of cognitive control techniques . to date, previous studies have mainly addressed global antidepressant effects of tdcs and not effects on more circumscribed phenotypes mediated by top-down pfc processes such as impaired or biased emotional learning processes. all these trials have applied the stimulation to patients while being in a resting position. nonetheless, recent neuropsychological studies indicate that tdcs effects appear to be "activity dependent", meaning that the stimulation effects are greater when the brain region being stimulated is simultaneously engaged in a cognitive task. therefore, in the present study we will apply tdcs to patients with unipolar major depressive disorder during cognitive behavioral therapy (cbt), a well-established and highly effective psychotherapeutic treatment for depression.

Eligibility criteria:
inclusion criteria: - unipolar major depressive disorder exclusion criteria: * neurological diseases or relevant psychiatric diseases other than major depressive disorder * current medication other than ssri or mirtazapine * manic episodes (lifetime) * psychotic symptoms (lifetime) * treatment with psychotherapy within the past 2 years * treatment with electroconvulsive therapy (lifetime)

Keywords: tdcs cognitive behavioral therapy
breast density change predicting response to adjuvant aromatase inhibitor

Conditions: Invasive Breast Cancer; Estrogen Receptor Positive Breast Cancer

Summary: breast density change after short term use of aromatase inhibitor in postmenopausal er positive breast cancer would predict endocrine responsiveness

inclusion criteria er positive breast cancer postmenopause women older than 60yr s/p bilateral salphingo-oophorectomy no menstruation history within 1yr and fsh\>30miu/ml ipsilateral invasive breast cancer undergone curative resection no evidence of distant metastasis capable of breast mri

Eligibility criteria:
inclusion criteria: * er positive invasive breast cancer postmenopause women age 60yrs or older s/p bilateral salphingo-oophorectomy no history of menstruation and fsh\>30miu planned for aromatase inhibitor unilateral breast cancer curative resection no evidence of distant metastasis exclusion criteria: * bilateral breast cancer male breast cancer acceptable for breast mri pregnancy or lactation

Keywords: breast density change endocrine therapy response aromatase inhibitor
study of right ventricular performance in pah patients treated with rapid dose treprostinil (remodulin)

Conditions: Pulmonary Arterial Hypertension

Summary: patients with pulmonary arterial hypertension (pah) are at much higher risk of death if the rv (right ventricle) is weak. the purpose of this study is to get a better understanding of the factors that determine rv adaptation and how the rv compensates on therapy. the investigator is also interested in how remodulin (treprostinil) infused over a short period (approximately 48-72 hours) affects the patient's quality of life, medical care, and personal health behaviors. treprostinil, also known as remodulin, has been approved by the us food and drug administration for use in the treatment of pah. the investigator has been treating patients with remodulin by rapid infusion (over 48 hours) for over 6 years. the investigator would like to establish this practice as safe and effective for the benefit of other centers that treat pah.


Eligibility criteria:
inclusion criteria: * patients with clinically suspected world health organization (who) group i pah * patients with new york heart association/who functional class ii-iv * patients with mean pulmonary artery pressure \>25 mmhg, pulmonary capillary wedge pressure \ 3 wood units * age \>18 and \<80 * no evidence of active ischemic heart disease exclusion criteria: * left ventricular ejection fraction \<50% * patients with significant restrictive lung disease (fvc \<60% predicted) and/or significant obstructive lung disease (fev1 \<55% predicted) within 1 year of enrollment if pulmonary function testing is available * patients with significant, investigator-determined parenchymal lung disease on chest x-ray or ct of the chest * history of pulmonary embolism within the last three months or chronic pulmonary embolism * poorly interpretable grey scale echocardiographic images * contraindications to right heart catheterization * moderate-severe aortic and mitral valve abnormality * active or previous use of pulmonary vasoactive medication within the previous 12 weeks * renal failure with serum creatinine clearance \<30 ml/hr * high-probability ventilation-perfusion scan

Keywords: pulmonary arterial hypertension right ventricular performance treprostinil remodulin