Kornimate/medical-research-clean huggingface dataset:
a clinical study of cd19/bcma car-t cells in the treatment of refractory poems syndrome, amyloidosis, autoimmune hemolytic anemia, and vasculitis

Conditions: POEMS Syndrome; Amyloidosis; Autoimmune Hemolytic Anemia; Vasculitis

Summary: a clinical study on the safety and effectiveness of cd19/bcma chimeric antigen receptor t cells in the treatment of refractory poems syndrome, amyloidosis, autoimmune hemolytic anemia, and vasculitis

poems syndrome, amyloidosis, autoimmune hemolytic anemia, vasculitis and other diseases may only show local pathological damage or systemic lesions. if they are not diagnosed and treated in time or poorly controlled, they will progress as the course of the disease progresses. risk of disability or even death.

Eligibility criteria:
inclusion criteria: * 1. diagnosed with poems syndrome, amyloidosis, autoimmune hemolytic anemia, vasculitis, and the curative effect of conventional hormones, radiotherapy and chemotherapy, protease inhibitors is not good and (or) no effective treatment means. 2. after glucocorticoids, cyclophosphamide or methotrexate treatments there are still relapsed and refractory diseases, or clearly show intolerance/toxicity to these drugs. 3. estimated survival time\> 12 weeks; 4. patients had a negative urine pregnancy test before the start of administration and agreed to take effective contraceptive measures during the test period until the last follow-up; 5. patients or their legal guardians volunteer to participate in the study and sign the informed consent. exclusion criteria: * subjects with any of the following exclusion criteria were not eligible for this trial: 1. history of craniocerebral trauma, conscious disturbance, epilepsy,cerebrovascular ischemia, and cerebrovascular, hemorrhagic diseases; 2. electrocardiogram shows prolonged qt interval, severe heart diseases such as severe arrhythm ia in the past; 3. pregnant (or lactating) women; 4. patients with severe active infections (excluding simple urinary tract infection and bacterial pharyngitis); 5. active infection of hepatitis b virus or hepatitis c virus; 6. systemic steroids have used in the 4 weeks before participating in the treatment (except recently or currently using inhaled steroids); 7. those who have used any gene therapy products before. 8. the proiferation rate is less than 5 times response to cd3/cd28 co-stimulation signal; 9. serum creatinine \> 2.5mg/dl or alt / ast \> 3 times uln or bilirubin \> 2.0mg/dl; 10. those who suffer from other uncontrolled diseases are not suitable to join the study; 11. hiv infection; 12. any situation that the researchers believe may increase the risk of patients or interfere with the test results.

Keywords: cd19 car-t bcma car-t poems syndrome amyloidosis autoimmune hemolytic anemia vasculitis
fus-tb vs cog-tb in small lesions of prostate cancer

Conditions: Prostate Cancer

Summary: to compare the positive detection rates of cog-tb vs fus-tb for prostate cancer with pi-rads 4 small lesions.

prostate cancer (pca) is the most frequent malignancy in male urogenital system. according to the world health organization's 2020 globocan statistics, there are approximately 1.4 million new cases and 375,000 deaths worldwide. pca is the second most common tumor in male patients after lung cancer and ranks fifth among cancer causes of death. currently, prostate specific antigen ( psa ), digital rectal examination (dre), multi-parametric magnetic resonance imaging (mpmri), prostate specific membrane antigen positron emission tomography/computed tomography (psma pet/ct) and other detection methods have played an important role in the diagnosis of pca, but the gold standard for confirming pca is the histopathological examination of prostate biopsy. performing mpmri before biopsy can help detect and locate prostate cancer with isup grade ≥2. studies have shown that the prostate imaging reporting and data system (pi-rads) may help improve the detection of clinically significant cancers. biopsy should be considered when pi-rads score 4 or 5. this clinical study intends to use the mpmri-trus image fusion ultrasound system to assist in guiding fus-tb, comparing to cog-tb to evaluate the application value of mpmr-trus image fusion in the detection of pca in prostate biopsy.

Eligibility criteria:
inclusion criteria: * 1) male who are between 18 to 80 years old; 2) meet any of the following criteria: 1. suspicious nodules of prostate under digital rectal examination(dre), with any psa value; 2. psa≥10μg/l; 3. 4μg/l≤psa\<10μg/l,f/t psa≤0.16; 3) suspicious lesions under mpmri, at least one lesion \<5mm, pi-rads 4; 4) good compliance; 5) must sign the informed consent form. exclusion criteria: * 1) diagnosed prostate cancer or acute prostatitis; 2) acute infection, or clinically significant urinary tract infection; 3) performed prostate puncture within 1 month; 4) cardiac insufficiency; 5) having high risk of bleeding or taking anticoagulants for a long time; 6) severe internal or external hemorrhoids, perianal or rectal lesions; 7) having severe osteoarticular diseases that can not be performed lithotomy; 8) hypertensive crisis; 9) patients who should not be anesthetized; 10) patients with mental illness or mental disorders and unable to understand the informed consent; 11) patients with electronic devices such as built-in artificial pacemaker, cochlear implants or nerve stimulators; 12) other surgical contraindications, or those considered unsuitable by the investigators.
pilates mat versus cervical stabilization exercises on balance in young adults with forward head posture

Conditions: Musculoskeletal Diseases

Summary: see if there will be no statistical significant difference between the effects of pilates mat versus cervical stabilization exercises on dynamic balance in young adults with forward head posture.

in modernized time, extended use of mobile phone and computers has increased anterior weight bearing of cervical spine leading to a variety of musculoskeletal disorders related to the neck by changing the biomechanical stress of cervical spine. additionally, forward head posture (fhp) alters the center of gravity (cog) of the body that lead to mechanical modifications related to postural control in the torso and every joint. the body attempts to adapt to these changes by altering its balance control mechanisms; these adaptations decrease balance ability while performing different activities and increase the risk of falling and musculoskeletal injury.

Eligibility criteria:
inclusion criteria: * subjects of both genders aged 18-25 years old with forward head posture will be included in this study. * subjects have forward head posture if the craniovertebral angle ≤ 50. * subjects complain non- specific neck pain for at least 3 months or at least two episodes of non-specific neck pain during the last three months. * normal body mass index (18- 24.9). exclusion criteria: * subjects with any spinal problems. * temporo-mandibular disease. * subjects with experience in pilates and who will not sedentary were excluded from the study. * previous surgery in the neck and shoulder regions * current participation in a structured exercises program * neurological symptoms of the upper extremities during screening tests (e.g., spurling test and upper limb tension tests) * red flags suggesting of cancer, infection, vascular insufficiency. * cervical radiculopathy or myelopathy

Keywords: balance craniovertebral angle
brain white matter injury in late preterm infants

Conditions: White Matter Injury

Summary: at 34 weeks, the brain weight of preterm infants is only 65% that of term infants, and the cortex volume is 53% that of term infants. damage at this stage of development will also change the trajectory of specific processes in the development of neurons and glial cells, resulting in neurological dysfunction in survivors.the incidence of cerebral palsy in late preterm infants is three times higher than in term infants, and about 25% lag behind term infants in learning, language and other neurodevelopment. at 34-37 weeks of gestation, oligodendrocytes are still late oligodendrocyte precursors and vascular development of the white matter area is immature, making the brain more prone to white matter injury (wmi).

1.1patients late preterm infants who were hospitalized in shengjing hospital from 1st january 2009 to 31st december 2022. risk factors prompting mri evaluation included: (1) premature rupture of fetal membrane, intrauterine distress or placental abruption before delivery; (2) asphyxia, resuscitation and rescue history, circulatory dysfunction and infection during or after delivery; and (3) early convulsions. 1.2 assessment of brain injury mri scans were analyzed by a radiologist and a newborn pediatrician who were unfamiliar with the clinical history. wmi diagnosis was carried out as described by reference, with some improvements. 1.3 collection of clinical data data, including delivery by cesarean section, gestational hypertension, diabetes mellitus, premature rupture of membranes and placental abruption, were collected for the mothers. gestational age, weight, gender, whether small for gestational age, apgar score, resuscitation history, circulatory disorders, early-onset sepsis, convulsions, and mri data were collected for the newborns. history of resuscitation and rescue refers to positive pressure ventilation, tracheal intubation, chest compression or epinephrine application during labor; circulatory disorders include at least two of the following indicators: prolonged capillary filling time, hypotension, oliguria, increased heart rate and increased liver. 1.4 instrumentation mri of the head was performed using an intera achieva 3.0t mri system (philips, best, netherlands). all infants were scanned by conventional mri and diffusion-weighted imaging (dwi). because of the retrospective study design, there are differences in imaging schemes, sequences and parameters measured.

Eligibility criteria:
inclusion criteria: * mri head examination with informed consent of guardian * age 34-36+6 weeks exclusion criteria: * other encephalopathies or congenital abnormality of brain development except white matter injury were excluded

Keywords: white matter injury;late preterm infants
a sugar-sweetened beverage reduction intervention for native american men

Conditions: Cardiovascular Disorder; Coronary Artery Disease; Diabetes Mellitus; Obesity-Related Malignant Neoplasm

Summary: this clinical trial develops and tests a culturally-appropriate educational program (indigenous sipin) for reducing sugar-sweetened beverage consumption in men affiliated with native american athletics communities. sugary drinks are drinks like pop, soda, and juice. increased sugar consumption may lead to an increased risk of chronic diseases, including obesity, diabetes, some types of obesity-related cancers, coronary heart disease, hypertension, and dental decay. a culturally sensitive program may help reduce sugar-sweetened beverage consumption in native american men

primary objective: i. conduct and analyze qualitative data from focus groups and key informant interviews with native american community members including native american leaders and community members to develop sugar sweetened beverage (ssb) intervention for native american men (sipsmarter lacrosse). outline: aim 1: participants complete interviews over 60 minutes and attend focus groups over 90 minutes in support of intervention adaptation and refinement. aim 2: participants receive the indigenous sipin intervention over 6 months, which includes in-person and/or virtual educational sessions weekly over 30 minutes for 12 weeks and text message communications twice a week (biw) for 12 weeks and then monthly thereafter up to month 6.

Eligibility criteria:
inclusion criteria: * at least 18 years or older * research conducted on tribal lands require tribal government approval. our project will not be occurring on tribal lands. the project will be working with native organizations off-territory * participants only must own a smart device in order to receive study text messages * at least 18 years or older * research conducted on tribal lands require tribal government approval. our project will not be occurring on tribal lands. the project will be working with native organizations off-territory * participants only must own a smart device in order to receive study text messages exclusion criteria: * research conducted on tribal lands require tribal government approval. since we do not currently have tribal government approval, our project will not be occurring on tribal lands
diafax i+ii-effects of inhalative anesthetics on left ventricular diastolic function

Conditions: Young Healthy Adults; Ventricular Dysfunction

Summary: anaesthetics may impair the diastolic function of the heart, but the importance of this finding for patients has not been sufficiently examined. specially the effects on diastolic function in patients with diastolic dysfunction has to be determined. the aim of this study is to examine the effect of isoflurane (only part i), sevoflurane and desflurane (part i+ii) on the diastolic left ventricular function by doppler echocardiography.

in part i, 60 healthy young subjects free from cardiovascular disease will be examined. in part ii, 50 patients with impaired diastolic but preserved systolic function, i.e., patients with arterial hypertension and ejection fraction \> 50%. doppler echocardiography will be performed at baseline before induction of anaesthesia, during anaesthesia in the spontaneously breathing patient, and in the mechanically ventilated patient.

Eligibility criteria:
inclusion criteria: * part i: 18- to 50-year-old patients undergoing surgical procedures under general anesthesia * part ii: 50-years-old patients or older with arterial hypertension under chronic antihypertensive medication subsequently undergoing surgical procedures under general anesthesia, ef \>50% exclusion criteria: * part i: any cardiac or pulmonary disease, any medication with cardiovascular effects or side effects, body mass index \> 30 kg/m2, esophageal reflux, emergency * part ii: history of myocardial infarction or coronary revascularization, severe lung disease, body mass index \> 30 kg/m2, esophageal reflux, emergency

Keywords: ventricular function diastolic function inhalative anaesthetics
tributyrin treatment in mild alzheimer disease: assessment of butyric acid effects via the gut-brain

Conditions: Alzheimer Disease (AD)

Summary: the goal of this clinical trial is to learn if tributyrin can help prevent or mitigate cognitive decline in individuals with mild alzheimer's disease (ad). the trial will also examine the safety and effects of tributyrin on inflammation and gut microbiota. the main questions it aims to answer are: does tributyrin improve cognitive function in patients with mild ad? does tributyrin reduce inflammation and oxidative stress? how does tributyrin affect gut microbiota and intestinal permeability? researchers will compare tributyrin to a placebo (a look-alike substance that contains no active ingredient) to evaluate its effectiveness. participants will: take tributyrin or a placebo every day for 12 weeks. undergo assessments of cognitive function, blood markers (such as bdnf and gfap), and gut health. the findings are expected to provide insight into the potential of tributyrin as a preventive intervention for alzheimer's disease.


Eligibility criteria:
inclusion criteria: * individuals diagnosed with mild ad within the past year (icd-10: f00.1). * voluntary consent to participate in the study in accordance with the declaration of helsinki. * not currently enrolled in any other clinical trial that could confound the results. exclusion criteria: * individuals with other potential causes of dementia, such as a history of severe traumatic brain injury, brain tumours, epilepsy, or central nervous system infections. * individuals involved in an intervention that interferes with the trial (immunosuppressive drugs, steroids, antibiotics, or received chemotherapy in the month prior to the start of the intervention). * individuals with gastrointestinal disorders.

Keywords: butyrate cognitive decline cytokines oxidative stress gut microbiome tributyrin alzheimer disease
evaluation of the long term efficacy of endovascular treatment of type 2 endoleaks

Conditions: Abdominal Aortic Aneurysm

Summary: endovascular treatment has become the first choice to repair abdominal aortic aneurym, but exposes patients to a risk of endoleaks. although treatment of type 1 and 3 endoleaks has proven to prevent aneurysms from rupture, controversies remain about type 2 endoleaks. the investigators described the different techniques of type 2 endovascular repair, and their efficacy at short and long term..


Eligibility criteria:
inclusion criteria: * all patients treated for type ii endoleaks by endovascular therapy exclusion criteria: * none
applied behavior analysis with technologies

Conditions: Autism; Autism Spectrum Disorder

Summary: applied behavior analysis (aba) is a therapeutic approach for autism that is based on the principles of behavioral theory, learning, and positive reinforcement. current research shows that early and intensive aba intervention is effective in reducing dysfunctional behaviors and promoting learning and enactment of socially appropriate behaviors. in this context, new approaches that attempt to integrate advanced technologies can play a key role. this experimental protocol aims to test whether the use of advanced technologies, such as tablets, as part of an intervention for a group of children with autism spectrum disorder (asd) is more effective than the traditional approach implemented in a control group of children with asd. the experimental protocol is aimed at enhancing cognitive skills, increasing new skills and acquiring functional/adaptive behaviors.


Eligibility criteria:
inclusion criteria: * children with diagnosis of autism exclusion criteria: * presence of other medical disorders

Keywords: autism autism spectrum disorder children applied behavior analysis aba
nerve growth factor in chronic pancreatitis

Conditions: Chronic Pancreatitis

Summary: this study is to understand the role of nerve growth factor(ngf) and other cytokines in the pancreatic fluid of patients with chronic pancreatitis. hypothesis: 1. pain does not correlate with changes in the pd morphology suggesting that pain in cp is not only a mechanical problem 2. pain in cp correlates better with the levels of ngf in the pancreatic juice. ngf is variably expressed in different morphological stages of cp and regulates the sensitivity of the peptidergic nociceptors and is upregulated in pancreatic inflammation.


Eligibility criteria:
inclusion criteria: * patients with established cp and none of the exclusion criteria mention below. exclusion criteria: * failure to obtain consent. * any comorbid condition with expected survival \< 1 year. * patients with pacemaker, implanted metallic prosthesis or other contraindications to do mrcp. * patients \< 18 years of age at time of consent

Keywords: tio identify role of ngf in pain in cp identify biomarkers related to progression of cp
evaluation of use of plastic bags to prevent neonatal hypothermia-part i

Conditions: Hypothermia; Immature Newborn

Summary: the overall hypothesis is that plastic bags used in combination with who thermoregulation care will reduce the incidence of hypothermia in preterm/low birth weight and full term infants when compared to routine who thermoregulation care alone. part i is for preterm/low birth weight infant with or without plastic head cover used during resuscitation.

this study will compare the incidence of hypothermia during the first hour after birth in preterm/low birth weight infants randomized to receive who thermoregulation care and a plastic bag (without drying) covering the torso and lower extremities (control group) or who thermoregulation care and a plastic bag (without drying) covering the torso, upper and lower extremities, and a portion of their head (intervention group). the axillary temperature of each infant will be taken initially within 15 minutes of birth and later at 1 hour after birth as the infant is removed from the plastic bag. seizures, hyperthermia, room temperature, and death will be recorded throughout the hospitalization for all infants. with an estimated baseline hypothermia rate of 41% and a 21% absolute risk reduction (51% relative risk reduction), a sample size of 182 will be used to have a power of 80% and a confidence interval of 95%.

Eligibility criteria:
inclusion criteria: * estimated gestational age 29-36 6/7weeks or birth weight 1,400-2500g * delivery in the hospital exclusion criteria: * infant admitted to the nicu * birth weight less than 1,400g * abdominal wall defect or myelomeningocele * major congenital anomalies * blistering skin disorder

Keywords: hypothermia low birth weight newborn resuscitation plastic bag
use of dexamethasone in uterine artery embolization

Conditions: Uterine Myoma; Adenomyosis

Summary: the primary purpose of this study is to investigate the effects of dexamethasone on inflammatory reactions after uterine artery embolization. the secondary purpose of this study it to investigate the effects of dexamethasone on postembolization syndrome (severe pain, nasea and vomiting).


Eligibility criteria:
inclusion criteria: * uterine artery embolization due to multiple myoma or adenomyosis exclusion criteria: * diabetic mellitus * steroid administration * liver or kidney dysfuntion * high baseline crp or leukocytosis (\>11,000/μl ) * drug allergy
topical garlic concentrate for alopecia areata in children

Conditions: Alopecia Areata

Summary: management of pediatric alopecia is particularly challenging given the chronicity of the condition, limited therapeutic response and devastating psychological effects. there is a paucity of safe and effective therapies in this population. the investigators propose to conduct and open label, prospective cohort pilot study using topical garlic concentrate ( garlicrich) for treatment of children with alopecia areata. study medication will be applied topically on affected area of the skin daily for 6 months. follow up visits will occur monthly to access the efficacy and safety of the proposed treatment .

the investigators are planning to enroll in the study 20 participants at sickkids. it is an open label, prospective cohort pilot study. patients enrolled in the study will be followed at the hospital for sick children for 6 months. participants will come for the study visits every month (7 study visits). during each study visit two investigators will independently access patient's hair density and calculate the salt score (severity of alopecia tool score), using the participant's digital photographs. patients will be provided with the study medication for all duration of the study. the results of the treatment will be compared with the baseline data ( pictures/ scores/ hair density) to evaluate the efficacy and safety of garlic concentrate in children with patchy alopecia areata.

Eligibility criteria:
inclusion criteria: * children aged 4 years and older up to 18 years of age * patches of alopecia areata that affect less than 50% of the scalp. * alopecia of at least 1 year duration without evidence of regrowth * informed written consent exclusion criteria: * any children experiencing significant spontaneous regrowth of terminal hair at the baseline visit. * any children treated with a topical, (including shampoos with active ingredients like minoxidil or clobetasol), intralesional or systemic agent likely to cause regrowth in alopecia areata within the past month from the baseline visit and during study period. * children with history of hypersensitivity to garlic. * children with widespread alopecia areata as alopecia totalis, universalis, ophiasis or diffuse alopecia areata.

Keywords: alopecia areata garlic concentrate