Kornimate/medical-research-clean huggingface dataset:
a study of cs1001 in combination with donafenib in subjects with advanced solid tumors

Conditions: Advanced Solid Tumor

Summary: this study will evaluate the safety, tolerability, pharmacokinetics and treatment effect of cs1001 in combination with donafenib in patients with advanced solid tumors.

this trail uses an open, multi-center study design, contains two parts: a dose escalation part and a dose expansion part.

Eligibility criteria:
inclusion criteria: * fully understand this study and voluntarily sign icf; * 18 to 75 years old (including 18 and 75 years old), male or female; * subjects with advanced solid tumors, including: phase i study: subjects with advanced solid tumors confirmed by histology or cytology that are not suitable for surgical resection, or have failed or tolerated standard treatment, or have no standard treatment. including but not limited to cholangiocarcinoma , head and neck squamous cell carcinoma (hnscc) and endometrial cancer. exclusion criteria: * any history of active autoimmune diseases or autoimmune diseases; patients with vitiligo or asthma that has been completely relieved in childhood, and patients who do not need any intervention after adulthood can be included; * participants with any condition that impairs their ability to take oral medication, such as lack of physical integrity of the upper gastrointestinal tract or malabsorption syndrome. * patients with uncontrolled pleural effusion, pericardial effusion, or ascites requiring repeated drainage and need to retain a catheter; * human immunodeficiency virus (hiv) antibody positive; * patients who are simultaneously infected with hepatitis b virus and hepatitis c virus; * lactating women. if they are willing to stop breastfeeding, they can also be included in this study.
adjuvant ovarian suppression plus aromatase inhibitor or tamoxifen in young women

Conditions: Breast Cancer

Summary: the objective of this study is to compare the curative effects in patients under the age of 35 with hormone receptor positive breast cancer and high recurrent risk factors including large tumor or metastatic lymph nodes randomized to ovarian function suppression (ofs) plus aromatase inhibitors or ofs plus tamoxifen as adjuvant endocrine therapy, and explore the differences of curative effects between different subtypes to provide direct evidence for treatments of young breast cancer patients.


Eligibility criteria:
inclusion criteria: 1. signed informed consent; 2. eastern cooperative oncology group (ecog) performance status ≤ 2; 3. patients pathologically diagnosed with hormone receptor positive invasive breast cancer: immunohistochemistry er positive (≥1%); 4. premenopausal patients with age ≤35 years (at least menstruate once for prior 3 months, assess menstruation situation before chemotherapy if have); 5. no distant metastasis; 6. clinical stage (tnm) meets at least one of the conditions as follow: t≥2cm or at least one region of regional lymph node metastasis (including micrometastases); 7. patients must have undergone a surgery and (neo)adjuvant chemotherapy, targeted therapy, radiotherapy (if necessary) according to chinese anti-cancer association guidelines and specifications version 2015 for diagnosis and treatment of breast cancer; 8. indexes of hematology and biochemistry conform to following standards: hgb≥10g/dl, wbc≥4,000/mm3, plt≥100,000/mm3, got, gpt, alp≤2xuln, tbil, dbil, ccr≤1.5xuln. exclusion criteria: 1. pregnant or lactating women or women of childbearing potential reject contraceptive measures; 2. history of organ transplantation (including autologous bone marrow transplantation and peripheral stem cell transplantation); 3. concurrent malignancies or history of non-breast malignancies within the 5 years prior to study entry, except for curatively treated basal cell and squamous cell carcinomas of the skin, carcinoma in situ of the cervix; peripheral nervous system disorders caused by diseases or history of obvious mental and central nervous system disorders; 4. prior use of neo-adjuvant chemotherapy after a definite diagnosis; 5. nervous system disorders caused by diseases or obvious mental disorder, which would affect patients right to consent and compliance, or make patients in critical condition; 6. serious hepatopathy (e.g., cirrhosis, etc.), nephropathy, respiratory illness, digestive illness or poorly controlled diabetes; 7. cardiac illness with obvious abnormal ekg or clinical symptoms, namely congestive heart failure, coronary atherosclerotic heart disease with obvious symptoms, arrhythmia difficult to control by drugs, or history of myocardial infarction within the 12 months prior to study entry or class iii/iv of cardiac function; 8. concurrent treatment in another investigational trial; 9. sensitivity or contraindication to any of the study medications.

Keywords: breast cancer ovarian function suppression (ofs) aromatase inhibitors（ais） tamoxifen（tam）
shared decision making for antipsychotic medications

Conditions: Schizophrenia; Schizoaffective Disorder; Schizophreniform Disorders; Delusional Disorder; Other Specified Schizophrenia Spectrum and Other Psychotic Disorder

Summary: this study aims to provide an evidence-based shared decision making intervention for antipsychotic medications, the antipsychotic medication decision aid (apm-da), for individuals experiencing early psychosis and provide, for the first time, an understanding of the shared decision making mechanism of action.

the investigators will conduct a cluster rct of the apm-da intervention at 6 ontrackny clinics, with 3 clinics implementing apm-da as part of their psychiatric visits and 3 randomized to serve as control offering treatment as usual (tau). the planned sample size is 120 ontrackny clients with first episode psychosis (fep). this real-world pilot cluster rct will assess the feasibility of the apm-da intervention in fep care, providing the first evidence for the effectiveness of the apm-da compared with tau and understanding of the sdm intervention's mechanism of action.

Eligibility criteria:
inclusion criteria: * ages 18 to 30 who have experienced nonaffective psychosis with a diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, delusional disorder, other specified/unspecified schizophrenia spectrum and other psychotic disorders (icd-10-cm diagnosis code f20.x) * current/past experiences with antipsychotic medications (apm; e.g., currently taking any antipsychotic medication, stopped taking, or considering stopping). * receive fep treatment in one of ontrackny clinics/sites randomized to intervention or treatment as usual (tau) - willing to participate in research interviews after each apm visit during the study period (3 months) exclusion criteria: * unable to provide informed consent * no experience with apm * not fluent (speaking, reading, writing) in english

Keywords: shared decision making psychosis schizophrenia antipsychotic medication intervention decision aid coordinated specialty care (csc) randomized controlled trial (rct)
a study to describe the safety and effectiveness of venetoclax in acute myeloid leukemia (aml) patients (revive study)

Conditions: Acute Myeloid Leukemia

Summary: this study will describe the safety and effectiveness of venetoclax in aml patients in routine clinical practice in israel. the decision to treat with venetoclax is made by the physician prior to any decision regarding participation in this study.


Eligibility criteria:
inclusion criteria: * participant diagnosed with acute myeloid leukemia (aml) and is eligible to receive venetoclax per israel ministry of health. * participant who will be treated with venetoclax and the decision to treat with venetoclax is made by the physician prior to any decision regarding participation in this study. exclusion criteria: - participant participating in an interventional trial within 30 days prior to starting venetoclax treatment.

Keywords: acute myeloid leukemia, venetoclax
efficacy of structured insulin order

Conditions: Type 2 Diabetes Mellitus

Summary: the purpose of this study is to determine whether an electronic order template for basal-bolus insulin will improve mean blood glucose in hospitalized general medical patients with poorly controlled type 2 diabetes.

the study randomly assigned internal medicine residents to use an electronic insulin order template plus basal-bolus ordering education versus education only. for all patients with uncontrolled type 2 diabetes treated by these physicians, mean blood glucose, rate of hypoglycemia, and rate of sliding scale insulin use were measured.

Eligibility criteria:
inclusion criteria: * blood glucose less than 60 mg/dl or greater than 180 mg/dl during hospital stay exclusion criteria: * diagnosis of type 1 diabetes

Keywords: type 2 diabetes mellitus basal-bolus insulin insulin ordering
systems analysis and improvement to optimize pmtct

Conditions: HIV

Summary: despite significant increases in global health investment and the availability of low-cost, efficacious interventions designed to reduce mother to child hiv transmission in low and middle income countries with high hiv burden, the translation of these scientific advances into effective delivery strategies has been slow, uneven and incomplete. as a result, pediatric hiv infection remains largely uncontrolled. enhancing the implementation of pmtct interventions through contextually appropriate systems analysis and improvement approaches can potentially reduce drop-offs along the pmtct cascade, leading to dramatic improvements in infant and maternal outcomes. the goal of this proposal is to develop a model for systematic assessment and improvement of pmtct services in sub-saharan africa. in specific aim 1, we will identify health system factors and service delivery approaches associated with high and low performing pmtct services in côte d'ivoire, kenya and mozambique. in specific aim 2 we will adapt evaluate the feasibility and impact of a systems analysis tool and associated performance enhancement approach for pmtct services in côte d'ivoire, kenya and mozambique. this systems analysis tool and associated performance enhancement approach is currently being developed and piloted for pmtct services in mozambique. the results of this implementation research are expected to generate knowledge of global health significance, and by disseminating the study results and intervention tools through the broad pepfar network, can rapidly impact pmtct service delivery enhancements across the highest need countries.


Eligibility criteria:
inclusion criteria: * health facility with pmtct services in central mozambique, northern cote d'ivoire or western kenya * health facility with at least 20 hiv-infected women identified in antenatal care per year exclusion criteria: * health facility over 20 kilometers from a main transport corridor * health facility with an ongoing prospective study or systems analysis and improvement approach in place

Keywords: hiv pmtct
gastric pull up versus free flap reconstruction for laryngo-pharyngeal defects

Conditions: Head and Neck Neoplasms; Pharyngectomy; Reconstructive Surgical Procedures

Summary: this study will compare the gastric pull up (gpu) with the free flap \[(specifically, anterolateral thigh (alt) and radial forearm free flap (rfff)\] techniques used in the reconstruction of alimentary tracts in patients who require laryngectomy and circumferential pharyngectomy for carcinoma resection. these two interventions will be compared by block randomizing 20 patients based on history of failed chemoradiation to undergo either alt or rfff. the primary outcome will be the type and number of postoperative complications. the secondary outcomes will include swallowing function, speech, and quality of life measures along with cancer specific endpoints.


Eligibility criteria:
inclusion criteria: * willing to provide informed consent, attend follow-up visits and complete questionnaires * have an eastern cooperation oncology group (ecog) performance status of 0-2 * patients with carcinoma of thyroid, larynx, hypopharynx, or cervical esophagus requiring surgery as a primary treatment modality or after chemoradiation treatment failure * laryngectomy and circumferential pharyngectomy as recommended by the head and neck tumor board exclusion criteria: * serious medical co morbidities or other contraindications to surgery * metastatic disease * pregnant or lactating women * patients whose clinical circumstances are such that one surgical intervention would be recommended over the other: the cancer extends into the the thorax as seen on pre-operative ct scan. in these patients, the gpu reconstruction is preferred. * patients who have liver cirrhosis or multiple previous surgeries on the stomach would not be candidates for the gpu and thus will be excluded from the study
estimation of internal jugular vein central venous pressure (cvp) by ultrasound

Conditions: Internal Jugular Size Measured by Ultrasound; Central Venous Pressure

Summary: to study the validity and reliability of estimation of the central venous pressure by measurement of internal jugular vein size using 2-dimensional ultrasound.

objectives: 1. to study the validity and reliability of estimation of the central venous pressure by measurement of internal jugular vein size using 2-dimensional ultrasound. 2. to evaluate the correlation of internal jugular vein cross sectional area and central venous pressure. methods: 1. the study design is prospective observational study. 2. we will include all patients scheduled for cardiac surgery in siriraj hospital and record both internal jugular size using 2-dimensional ultrasound just before central venous catheter insertion. the central venous pressure will be recorded and the ultrasound picture will be measured. 3. the data will be analyzed.

Eligibility criteria:
inclusion criteria: * patients scheduled for cardiac surgery * need central venous catheterization intraoperatively * elective surgery * age \> 18 exclusion criteria: * neck pathology * history of internal jugular or svc thrombosis * limited neck mobility * severe valvular lesion * decompensated heart failure

Keywords: internal jugular vein cross sectional area ultrasound central venous pressure
the relationship between left atrial pressure and cardiac function after atrioventricular node ablation

Conditions: Atrial Fibrillation

Summary: effects of left atrial pressure-guided ventricular rate changes on cardiac function after atrioventricular node ablation combined with left bundle branch pacing

effects of left atrial pressure-guided ventricular rate changes on cardiac function after atrioventricular node ablation combined with left bundle branch pacing. for patients with non-valvular atrial fibrillation who received atrioventricular node ablation combined with left bundle branch pacing in our hospital, a left atrial pressure catheter was used to monitor atrial pressure during the operation, and a lower average atrial pressure was obtained by adjusting the pacing frequency of the pacemaker. in a randomized controlled manner, the postoperative echocardiography, cardiothoracic ratio, cardiac function, etc. were compared between patients without atrial pressure monitoring and those who received atrial pressure adjustment, in order to clarify the effect of left atrial pressure-guided ventricular rate adjustment on atrioventricular node ablation combined with left bundle benefit of pacing patients.

Eligibility criteria:
inclusion criteria: 18-85 years old atrial fibrillation patients exclusion criteria: there is a history of pacemaker implantation; patients after coronary artery bypass grafting; severe coronary stenosis or occlusion cannot be treated with reperfusion;

Keywords: atrial fibrillation; atrioventricular node ablation; left bundle branch pacing
dapagliflozin versus dexamethasone role in pre-operative management of non- diabetic brain tumor patients

Conditions: Glioma; Dapagliflozin (Forxiga); Dexamethasone

Summary: the aim of the study is to compare between the role of dapagliflozin versus dexamethasone in pre-operative management of non-diabetic glioma patients on levetiracetam as anti-seizure drug.

* this is a randomized, parallel, and controlled study, which will be conducted on pre-operative non-diabetic glioma patients on levetiracetam as anti-seizure drug. \* this study will be conducted pending registration at clinicaltrials.gov. * all patients will give their written informed consents. * data of patients will be confidential. * any unexpected risk will be reported to patients and ethical committee on time. \* randomization will be carried out based on days on hospital admission.

Eligibility criteria:
inclusion criteria: * males \& females. * age: between 18 and 75 years old. * pre-operative non-diabetic glioma patients on levetiracetam. • diagnosis will be confirmed by: * the initial clinical examination. * magnetic resonance imaging of the brain (mri) with contrast. exclusion criteria: * age: \> 75 years old, and \<18 years old. * breast feeding female. • pregnant female. * egfr\< 30 ml/minute/1.73 m2. * patients with diabetes mellitus. * patients with diabetic ketoacidosis. * patients with urinary tract infection. * dehydrated patients till normalized. * lower limb amputation patients. * sglt2 inhibitors hypersensitivity. * severe hepatic patients (child-plug score class-c).
fixation of skin grafts in patients with burns: comparison between cyanoacrylate glue and skin staples

Conditions: Grafting, Skin; Burn

Summary: skin graft fixation is essential for the success of its survival. there are several common methods for skin graft fixation including sutures, skin staples and glue. the study objective is to compare between skin graft fixation with staples and glue in burn patients. the study is retrospective. it includes 44 patients that were hospitalized in the burn unit, rabin medical center, israel with 2nd and 3rd degree burns, total body surface area 1-50% during 1/2002-5/2003.all patients were operated for debridement and skin grafting. in 29 patients the skin graft was fixated with staples and in 15 with cyanoacrylate glue (histoacryl). the parameters that will be compared are skin graft take, hospitalization length and local infection.


Eligibility criteria:
inclusion criteria: * hospitalized patients with 2nd and 3rd degree burns who were operated for debridement and skin grafting * burn total body surface area 1-50% exclusion criteria: * burn total body surface area\> 50%

Keywords: skin graft fixation cyanoacrylate glue skin staples
neural correlates of driving and cannabis

Conditions: Cannabis Use; Driving Impaired

Summary: driving is a set of complex tasks and requires use of multiple cognitive domains, including attention, planning, and memory. in laboratory studies, the main psychoactive component in cannabis, delta-9-tetrahydrocannabinol (thc), was shown to impair short-term memory, attention, reaction time, tracking, and coordination, resulting, for instance, in significantly more deviations from the lane and increased break latency. surveys and epidemiological studies suggest that cannabis consumption is associated with increased risks of collision. the current study aims to evaluate individual driving behavior and performance on various neurocognitive tests and their correlated neural networks while under the influence of cannabis and while sober. the investigators will use the stisim driving simulator, which is fully mri compatible, to study brain activation, while participants are performing various driving maneuvers. the goals of the study are: 1. identify driving performance and patterns in brain activation associated with cannabis exposure and compare them to brain patterns of the same participants while sober; 2. compare participant's performance on cognitive tasks while under the influence of cannabis and sober; 3. look for correlations between concentration of cannabinoids in the participants' blood and their driving performance and performance on cognitive tasks; 4. correlate demographic variables and personal history (e.g. tolerance to drug) with performance and brain activation while driving under the influence of cannabis.


Eligibility criteria:
inclusion criteria: * valid driver's license * have normal or corrected-to-normal vision * have had prior experience consuming cannabis * are currently not and have not been regular users in the past 5 years (regular use is defined as at least 1 time per week for at least 1 month) * prescribed medical cannabis exclusion criteria: * not fluent in english * do not meet mri screening criteria * use 50 mg/day of morphine equivalents * history of neurological, neurodegenerative or psychiatric diseases * any serious sensory or motor impairments * pregnant women or women trying to get pregnant, or breastfeeding * serious lung, liver, kidney, and heart problems, including angina, coronary artery disease, and arrhythmia, and peripheral vascular disease * personal or family history of mental disorders or alcohol or drug abuse or dependence

Keywords: mri cannabis driving
lifestyle intervention's impact on health care costs

Conditions: Diabetes Mellitus, Type 2; Obesity

Summary: the ican pilot project aims to evaluate the differences in economic, clinical and quality of life outcomes of a nutrition intervention involving lifestyle case management and medical nutrition therapy by a registered dietitian compared to usual medical care in obese persons with type 2 diabetes. the intervention is aimed at moderate weight loss (\> 5-10%), improvement in diet quality and an increase in physical activity.


Eligibility criteria:
inclusion criteria: * bmi \> 30 kg/m2, calculated from measured weight and height. * type 2 diabetics on medication for their diabetes. * age 20 -60 years of age. * have phone. * fluency in reading, writing and comprehension of english * have qualchoice as their primary health insurer. exclusion criteria: * depression, bdi score \> 20 * pregnancy

Keywords: health behavior lifestyle health care costs quality of life
effects of lidocaine spray for reducing pain during endometrial aspiration biopsy : a randomized controlled trial

Conditions: Uterine Bleeding

Summary: endometrial aspiration biopsy has been accepted as a diagnostic procedure of choice for women with abnormal uterine bleeding to examine endometrial pathology. the procedure has high accuracy comparing to conventional fractional curettage. however, it is associated with significant pain during the procedure. in general, there is no specific recommendation regarding the proper anesthesia used during the procedure. the aim of this study is to examine the effect of lidocaine spray for reducing pain during the endometrial aspiration procedure by comparing it with placebo and no intervention.


Eligibility criteria:
inclusion criteria: * women undergoing endometrial aspiration biopsy at maharaj nakorn chiang mai hospital exclusion criteria: * lidocaine allergy * pregnancy * previous uterine or cervical surgical procedures * neurological abnormalities * coagulopathy * infection of cervix, vagina, or pelvic cavity * taking any analgesic drugs within 4 hours before the procedure
asymptomatic flu project

Conditions: Influenza

Summary: although clinical presentation of influenza is often symptomatic, asymptomatic cases also occur. the knowledge of the incidence of asymptomatic influenza among healthcare workers is very important because of the risk of cross-transmission to hospitalized patients. the principal objective of the study is to estimate the incidence of symptomatic and asymptomatic influenza among healthcare workers in short-stay wards. the results of this study will lead to a better understanding of the burden of asymptomatic influenza among healthcare workers and might be used as an argument to increase influenza vaccine coverage among healthcare workers.


Eligibility criteria:
inclusion criteria: * volunteer health-care workers * working in the following wards: short-stay, inpatient (including icu) and emergency exclusion criteria: * presence of influenza symptoms at enrolment * programmed absence (maternity leave, vacation, etc.) * administrative agents

Keywords: influenza health care workers nosocomial asymptomatic france