Kornimate/medical-research-clean huggingface dataset:
prevalence of hyperprolactinemia in systemic scleroderma

Conditions: Sclerosis, Systemic; Scleroderma; Hyperprolactinemia

Summary: systemic sclerosis is an autoimmune and inflammatory disease characterized primarily by fibrosis and vascular involvement. we know that the immune system is disrupted in systemic sclerosis, but there are probably other mechanisms to explain the disease, including deregulation of certain proteins such as prolactin


Eligibility criteria:
inclusion criteria: scleroderma patients: * man or woman over 18 years old * with systemic sclerosis meeting acr-eular 2013 criteria * having given his no opposition * being social insured healthy subjects: * man or woman over 18 years old * donation of blood to the efs * matched on age (+/- 5 years) and sex * having given his no opposition exclusion criteria: * man or woman under 18 years old * pregnant or breastfeeding women * receiving medical treatment inducing dysfunction of the hypothalamic pituitary axis * refusing or unable to give no objection

Keywords: systemic sclerosis scleroderma prolactin
ketamine efficacy for acute severe bronchospasm in icu: macanudo trial

Conditions: Critical Illness; Asthma; Bronchospasm

Summary: despite few scientific evidence that could support the use of ketamine in adult patients undergoing acute bronchospasm requiring mechanical ventilation (mv), ketamine is largely employed in this setting. the aim of this study is therefore assess more definitively the real benefit of using ketamine in patients with severe bronchospasm, requiring icu stay and need for mv in order to establish or refute the use of this drug as "standard therapy" in these cases.


Eligibility criteria:
inclusion criteria: * patients with acute exacerbation of copd or status asthmaticus, undergoing controlled mechanical ventilation * acute bronchospasm, defined as airway resistance value (rsr max) greater than 12, use of inhaled therapy with bronchodilators and systemic corticosteroids * patients requiring the use of continuous intravenous sedation for optimization of ventilation exclusion criteria: * contraindication or history of previous adverse events with the use of the studied drugs * other diagnostic potential rsr increase of not causing bronchospasm (bronchial obstruction, acute respiratory distress syndrome adult, pulmonary fibrosis)
low dose dexamethasone for distal radius fractures

Conditions: Post Operative Pain; Distal Radius Fracture

Summary: the addition of the steroid dexamethasone to a single injection of local anesthetic has been shown to significantly prolong the duration of peripheral nerve blockade compared to local anesthetic alone. this allows for improved post-operative pain scores and reduces opioid use in the early post-operative period. however, the use of a steroid adjuvant in regional nerve blocks is generally not considered standard of care, and there is considerable variation among anesthesiologists regarding preferred formulations and the role of adjuvants in regional anesthesia. a recent study from our institution demonstrated the effectiveness of dexamethasone directly mixed with local anesthetic at multiple doses compared to placebo for upper extremity surgery. with this prospective randomized controlled blinded trial, we hope to definitively establish which method of adjuvant dexamethasone administration is superior in extending the effects of a brachial plexus nerve block.


Eligibility criteria:
inclusion criteria: * patients over the age of 18 undergoing open reduction and internal fixation of a distal radius fracture less than 3 weeks from injury with a volar plate technique * american society of anesthesiologists (asa) levels 1 through 3 at time of surgery * opioid naïve patients exclusion criteria: * history of drug/opioid/alcohol abuse * polytrauma patients * history of inflammatory disorder, infection, dementia, psychiatric/neurological disorder, relevant drug/local anesthesia allergy, relevant chronic upper extremity pain (rsd, fibromyalgia, neuralgia, etc) * excessive bmi * pregnancy
acute exercise on neurocognitive function among adults with/without generic risk of ad

Conditions: Alzheimer Disease 2 Due to Apoe4 Isoform

Summary: this study explores the acute exercise effect on neurocognitive function and also its potential moderators in an exercise setting and apolipoprotein e (apoe) genetic risk.

acute exercise has emerged as a modifier to multiple aspects of cognitive function; however, its effect on populations with different risks of alzheimer's disease (ad) and the role of exercise variance and apoe genotype within the effect reminds underestimated. the current study aimed to examine the acute exercise effect on neurocognitive function from behavioral and neuroelectric perspectives among cognitively normal late-middle-aged adults. additionally, we determined whether variations in exercise intensity and duration and the presence of the apoe ɛ4 allele modulated the effect.

Eligibility criteria:
inclusion criteria: 1. adults aged between 50 and 70 years old 2. normal or corrected-to-normal vision based on the minimal 20/20 standard 3. cognitively normal as mini-mental state examination scores (mmse) \> 26 exclusion criteria: 1. neurological or psychiatric disorders 2. cardiovascular disease 3. risk of cardiovascular fitness assessment based on the physical activity readiness questionnaire (par-q) 4. red-green color blindness.

Keywords: aerobic exercise apoe genotype event-related potential executive function exercise prescription
assessing the effect of neglected tropical diseases on plasmodium falciparum transmission in an area of co-endemicity

Conditions: Malaria Transmission

Summary: assessing the effect of neglected tropical diseases on plasmodium falciparum transmission in an area of co endemicity.

the project is divided in three different work packages that cover the life cycle of p. falciparum : 1. in work package 1 (wp1) the investigators will assess whether s. haematobium infection increases the human reservoir of p. falciparum by increasing the carriage rate and incidence of p. falciparum gametocytaemia as well as by increasing the proportion and incidence of subject with sub-microscopic p. falciparum infection. the investigators will also determine whether this increase in gametocyte carriage is a consequence of an impairment of the immune response of helminth infected subjects to p. falciparum. 2. in work package 2 (wp2) the investigators will determine whether the transmission of the sexual forms of p. falciparum from the human host to mosquito is increased in s. haematobium infected subjects compared to uninfected controls. moreover the investigators will study whether the immunological changes induced in s. haematobium infected subjects lead to a decrease of the transmission reducing activity of igg specific to pfs48/45 and pfs230 (both capable of blocking/impairing further development of p. falciparum in the mosquito gut). 3. finally in work package 3 (wp3) the investigators will assess whether s. haematobium infection affects the transmission of p. falciparum from the mosquito to the human host. this effect will be determined indirectly by assessing whether s. haematobium infected subjects are more attractive to mosquitoes.

Eligibility criteria:
inclusion criteria: * subjects aged from 6 to 30 years * without severe or moderate disease * agreement to be enrolled in the study (written informed consent or consent by the legal representative and assent) * living in the study area for at least 1 year exclusion criteria: * anaemia with haemoglobin less than 8g/dl * know sickle cell disease * macroscopic haematuria * any other know severe disease

Keywords: schistosoma haematobium plasmodium falciparum transmission
the performance-perceptual test as a counseling tool

Conditions: Hearing Impairment

Summary: the purpose of the study is to determine whether a new test of ability to understand speech in noise and an associated counseling program can improve hearing aid satisfaction. participants complete routine hearing tests, some hearing-related questionnaires and the new speech test. one group of participants receives the new form of counseling, the second group does not. hearing aid satisfaction following 10 weeks hearing aid use is compared across the groups.

hearing aid dissatisfaction continues to be disappointingly high, even though hearing aid technology has improved dramatically over the last 10 years or so. unfortunately, the results of most commonly used self-report measures cannot be directly compared with the results from performance measures since the modes of testing are very different. thus, it is hard for clinicians to reconcile data from individuals reporting more handicap or less hearing aid satisfaction than would be expected from their performance. in this study, the investigators use a test known as the performance-perceptual test (ppt) to determine whether simple counseling based upon discussion of ppt results can be used to better align perceived and measured ability to understand speech-in-noise; and, more importantly, whether such counseling can decrease reported handicap and improve hearing aid satisfaction. hearing aid users complete the ppt for aided and unaided listening, along with standardized questionnaires measuring reported auditory disability, handicap and hearing aid satisfaction. following this, subjects are randomly assigned to one of two groups. subjects in group 1 receive counseling from the experimenter in the form of an explanation and discussion of their ppt results. subjects in group 2 also participate in a discussion with the experimenter, but it does not include an explanation of the ppt. two weeks after enrollment in the study subjects complete a second set of questionnaires. ten weeks after study enrollment subjects return to the laboratory to rerun the test battery. the impact of the counseling upon ppt values, reported handicap and hearing aid satisfaction and benefit will be compared across the two groups.

Eligibility criteria:
inclusion criteria: * mild-to-moderate symmetrical sensorineural hearing loss * current users of binaural hearing aids exclusion criteria: * conductive hearing impairment or other otological pathology * a score less than age-based norms on the mini mental state examination * asymmetrical hearing loss * no prior use of hearing aids

Keywords: audiologic rehabilitation counseling
hepatitis inequalities study

Conditions: Chronic Hepatitis B; HEPATITIS C VIRUS CHRONIC INFECTION

Summary: health inequality in liver diseases including age, gender, ethnicity and socioeconomic status has been increasingly recognised and potentially hinder hepatitis elimination. health inequality has significant impact to evaluate the impact diagnostic and treatment uptake rates of chronic viral hepatitis on risk of hepatocellular carcinoma (hcc), hepatic event and liver-related death in patients with chronic hepatitis b and/or c. to overcome the limitation of small prospective cohort study of limited recruitment period, retrieving information from the clinical data analysis and reporting system (cdars) from hospital authority (ha) will be one of the best way to answer these questions.


Eligibility criteria:
inclusion criteria: * patients will be eligible if they have any of these viral markers (hbeag / hbsag / hbv dna / hcv rna) and/or any of the following diagnosis codes (icd-9 070-070.9; 348.3, 349.82, 456, 456.2, 456.8, 567.2, 567.8, 570, 571.2, 571.5, 571.6, 572.2, 572.3, 572.4, 789.5) checked or coded in any public hospitals or clinics from 1 january 2000 to 31 march 2024. exclusion criteria: * patients with missing age, gender, ethnicity and socioeconomic status * (subgroup analysis for ethnicity and socioeconomic status) patients with missing ethnicity and socioeconomic status * serious medical illnesses or malignancy with life expectancy \&lt;1 year
optical frequency domain imaging for non-melanoma skin cancers

Conditions: Non-Melanoma Skin Cancer (NMSC)

Summary: the purpose of this research study is to find out if a non-invasive imaging device called optical frequency domain imaging (ofdi) can help doctors to see the tissue and blood vessels that are related to non-melanoma skin cancers. ofdi was designed to see microscopic details of your skin without needing to use any invasive techniques such as surgery or biopsy.

non-melanoma skin cancer (nmsc) is the most common cancer in the united states, with more than 750,000 diagnosed patients treated every year. its prevalence and incidence have significantly increased over the past two decades and it has been estimated that 20% of all americans will develop this type of cancer during their lifetime (neville et al., 2007). biopsy and surgical resection of nmsc can result in tissue mutilation and scaring. therefore, there is a need for new imaging technologies that can be used to non-invasively guide biopsy and surgery. optical frequency domain imaging (ofdi) is a second-generation imaging implementation of optical coherence tomography (oct) developed at the wellman center. ofdi provides high-resolution three-dimensional imaging in tissue. it uses an interferometric depth-sectioning technique and employs a near-infrared light source. through analysis of phase information in the recorded signal. ofdi can detect blood vessels within tissues and tumors. importantly, ofdi-based vascular imaging can be performed without the need for exogenous contrast agents, making it relatively easy to deploy in clinical settings.

Eligibility criteria:
inclusion criteria: 1. male or female subjects with fitzpatrick skin type i-vi 2. subjects with ages between 18 and 80 years of age 3. presence of at least one nmsc lesion exclusion criteria: 1. subjects with active localized or systemic infections 2. subjects participating in potentially confounding clinical studies of investigational therapies, either drug or device. 3. subjects taking any topical/systemic chemotherapy or immunosuppressants 4. subjects who are pregnant and/or breastfeeding 5. subjects with tape adhesive allergies

Keywords: skin cancer optical imaging optical coherence tomography optical frequency domain imaging
comparison of manual therapy and auricular vagus nerve stimulation in chronic low back pain

Conditions: Low Back Pain; Pain

Summary: especially in the elderly population, low back pain is a major health problem, causing great human costs, negatively affecting the quality of life and limiting the daily activities of individuals


Eligibility criteria:
inclusion criteria patients aged 20-65 years with nonspecific chronic low back pain will be included in the study. exclusion criteria * cognitive impairment * severe osteoprosis * neurological deficit * being pregnant * operations on the lumbar region

Keywords: pain low back pain
glucose and fructose stimulated brain activity in obese subjects

Conditions: Exploratory Behavior

Summary: the objective is to investigate neuro-anatomical correlates of the regulation of energy intake by means of functional mri. administration of glucose as well as fructose is followed by functional brain mri, and findings are correlated with serum glucagon-like peptide 1 (glp-1) levels as an endogenous satiety signal in obese humans.


Eligibility criteria:
inclusion criteria: * right-handed healthy males, no drugs, non-smoking exclusion criteria: * drug abuse, smoker, left-handed, claustrophobia
young pectus excavatum patients and genetic defects

Conditions: Genetic Disease; Pectus Excavatum; Children, Adult

Summary: in most pectus excavatum (pe) patients an underlying genetic defect is not found with molecular analysis, as a direct genetic link with pe has yet to be found and because potential underlying genetic disorders are quite rare. only one-fifth of all pe cases are identified in the first decade of life and thus of congenital origin making younger pe patients a unique patient group. therefore, the research question is; is early-onset pectus excavatum (pe) more likely to be part of a genetic defect than pe which became apparent during puberty or adolescence?

importance: in most pectus excavatum (pe) patients an underlying genetic defect is not found with molecular analysis, as a direct genetic link with pe has yet to be found and because potential underlying genetic disorders are quite rare. only one-fifth of all pe cases are identified in the first decade of life and thus of congenital origin making younger pe patients a unique patient group. objective: the investigators hypothesize that early-onset pe is more likely to be part of a genetic defect than pe which became apparent during puberty or adolescence. design: cohort study setting: single center participants: all pediatric pe patients aged younger than 11 years upon first visit of the outpatient clinic of the department of pediatric surgery at the sophia children's hospital - erasmus medical center between 2014 and 2020 were identified and informed consent was obtained for inclusion. two clinical geneticists performed the anamnesis and physical examination. molecular analysis was performed based on the differential diagnosis. all young pe patients which have been referred for genetic counseling already, were analyzed retrospectively. main outcome: incidence of genetic defects

Eligibility criteria:
inclusion criteria: * patients with pectus excavatum aged younger than 11 years upon first visit of our outpatient clinic exclusion criteria: * none

Keywords: pectus excavatum children gene syndrome
reliability of 6-minutes walking test in hip fracture patients

Conditions: Hip Fracture

Summary: the purpose of this study is to examine the relative (icc) and absolute intertester reliability of the 6-minutes walking test in hip fracture patients (n=50) in an outpatient facility. the data collection is conducted by two physiotherapists, who are blinded to each other. the physiotherapists are randomized so they each are doing an equal number of baseline tests.


Eligibility criteria:
inclusion criteria: * 60 years or above * hip fracture patients with a intra - or extra capsular hip fracture * testing within 3 - 5 weeks postsurgery in an outpatient facility * no weightbearing restrictions on the fractured limb * normal cognitive level (mini mental state examination(mmse) - score ≥20 points) * participants should not experiencing hip related pain more or less than moderate according to verbal ranking scale when resting * to have the ability to write and understand danish language exclusion criteria: - mmse score ≤19 points

Keywords: hip fracture 6-minutes walking test reliability
cd276 car-t for patients with advanced cd276+ solid tumors

Conditions: CAR; Solid Tumor

Summary: this study is a clinical study of cd276 car-t in the treatment of patients with advanced solid tumors. the purpose is to evaluate the safety and effectiveness of targeting cd276 auto-chimeric antigen receptor t cells in the treatment of cd276-positive advanced solid tumors.


Eligibility criteria:
inclusion criteria: * age 3-70 * expected survival time ≥ 12weeks * ecog 0-2 * at least second-line or above chemotherapy failed * according to the evaluation criteria for the efficacy of solid tumors (recist 1.1), at least one measurable lesion (non-nodular lesion with longest diameter ≥10mm, or nodular lesion with short diameter ≥15mm) * liver and kidney function, heart and lung function meet the following requirements: 1. creatinine is within the normal range; 2. left ventricular ejection fraction ≥ 45%; 3. baseline blood oxygen saturation\>91%; 4. total bilirubin≤1.5×uln; alt and ast≤2.5×uln * understand the trial and have signed the informed consent exclusion criteria: * those who have graft-versus-host disease (gvhd) or need to use immunosuppressive agents * hepatitis b surface antigen (hbsag) or hepatitis b core antibody (hbcab) positive and peripheral blood hbv dna titer test is not within the normal reference range; hepatitis c virus (hcv) antibody positive and peripheral blood hcv rna positive; human immunodeficiency virus (hiv) antibody positive; cmv dna test positive; syphilis test positive * severe heart disease * systemic diseases judged by the investigator to be unstable: including but not limited to severe liver, kidney or metabolic diseases that require medication * within 7 days before screening, there are active infections or uncontrollable infections that require systemic treatment (except for mild urogenital infections and upper respiratory tract infections) * women who are pregnant or breastfeeding, and female subjects who plan to become pregnant within 1 year after cell reinfusion, or male subjects whose partners plan to become pregnant within 1 year after cell reinfusion * those who have received car-t therapy or other genetically modified cell therapy before screening * subjects who are receiving systemic steroid therapy at the time of screening and the investigator determines that they need long-term systemic steroid therapy during the treatment period (except for inhaled or topical use) * participated in other clinical studies within 3 months before screening * central nervous system metastases are known to occur and for suspected central nervous system metastases, head mri examination is required to rule out * patients with partial or complete intestinal obstruction and complete biliary obstruction that cannot be relieved by active treatment * with more than a moderate amount of ascites, or after conservative medical treatment (such as diuresis, sodium restriction, excluding ascites drainage) for 2 weeks, the ascites still shows a progressive increase * according to the researcher's judgment, it does not meet the situation of cell preparation * situations that other researchers think are not suitable for inclusion