Kornimate/medical-research-clean huggingface dataset:
rct mesenchymal stem cells versus hyaluronic acid in oa knee):

Conditions: Osteoarthritis, Knee

Summary: the purpose of this study is to evaluate the therapeutic effect of adult autologous mesenchymal stem cells (abbreviated as mscs) in patients with osteoarthritic knee and compare to intra articular injection of synvisc-one.

study participants: this study will involve patients affected by osteoarthritis who comply with the inclusion and exclusion criteria. 30 patients, between the age of 18 and \<65, will be enrolled in the study and randomized into three groups to receive either an injection of mscs, hyaluronic acid (ha) or no injection. type of study: this is a randomized control study. treatment method: each patient will randomly be assigned to one of the following treatment groups: group a) mesenchymal stem cells (mscs) group b) hyaluronic acid (ha) group c) no injection treatment: group a) autologous mesenchymal stem cells treatment (mscs) the mscs treatment group patients will receive an intra-articular injection of a mesenchymal stem cell (mscs) suspension in the affected knee. the treatment will be carried out after the patient has received a blood test and clinically evaluated at t0. t0: beginning of the study, blood test and bone marrow aspiration. t30: intra-articular injection of mscs t44: adverse events follow up 2 weeks after intra-articular injection (by phone) group b) hyaluronic acid (ha) the patient will be given a single intra-articular injection of hyaluronic acid sodium salt, synvisc-one (trb chemedica ltd.) the hyaluronic acid will be purchased for the patient from the manufacturer or from the pharmacy of the hospital. the intra-articular injection will be carried out after the patient has received a clinical evaluation at t0. t0: beginning of the study t30: intra-articular injection of synvisc-one (ha) t44: adverse events follow up 2 weeks after intra-articular injection (by phone)

Eligibility criteria:
inclusion criteria: * male and female subjects aged between 18 and \< 65 * radiological evidence of osteoarthritis with kellgren and lawrence grade 2 and 3 * patients on a pain level equal to or higher than 5 on a vas scale of 10 exclusion criteria: * previous cases of alcoholism or drug abuse * pregnancy and breast-feeding * serious pathologies such as carcinoma or autoimmune disease * hypersensitivity toward hyaluorinc acid * undergoing steroid-based systemic therapy or interrupted since less than 1 month * significant hematologic diseases * mechanical instability, ligamentous laxity/deficiency or gross deformity
adapting the hope social media intervention to reduce prescription drug abuse

Conditions: Non-Cancer Chronic Pain

Summary: the harnessing online peer education (hope) intervention combines social media with a psychology-based interventions to change behavior. this intervention is being applied to reduce prescription drug abuse among patients with chronic pain.


Eligibility criteria:
inclusion criteria: * (a) ucla health system patient, * (b) ≥ 18 years of age, * (c) on chronic opioid therapy (\> 3 and \< 12 months) for chronic non-cancer pain as reported by their physician who referred them. exclusion criteria: ° does not satisfy inclusion criteria
get going after concussion 2.0

Conditions: Commotio Cerebri; Mild Traumatic Brain Injury

Summary: the study tests the promising results of a previous study (gain 1.0) in a larger rct (gain 2.0) which takes place in the municipalities of central denmark region where citizens live their daily lives and whose health- and social care systems support citizens who experience persisting pcs.

concussion, the mildest form of traumatic brain injury, is an important public health concern. recent studies estimate that persistent post-concussion symptoms (pcs) are present in almost half of the affected citizens at one year post-injury. prospective studies have demonstrated that these citizens are at risk of developing long-lasting symptoms which are associated with high societal burden due to long-term impact on labour market attachment and increased use of health care and social benefits. in denmark, there has in recent years been an increasing awareness on societal impact and personal consequences of pcs. accordingly, clinicians as well as social workers and therapists in the municipalities point to the gab in knowledge concerning pcs and advocate urgently for evidence-based treatment for these citizens. recently, the research group behind this application developed a novel early intervention - "get going after concussion" (gain 1.0) - for citizens who experience persistent pcs three to six months post-concussion. the intervention was tested in a randomized controlled trial (rct) with promising results. however, it was delivered in a single hospital setting in which these citizens are normally not cared for. in this study the intention is to test the results of gain 1.0 in a larger rct (gain 2.0) which takes place in the municipalities of central denmark region where citizens live their daily lives and whose health- and social care systems support citizens who experience persisting pcs.

Eligibility criteria:
inclusion criteria: 1. concussion caused by a head trauma according to the diagnostic criteria recommended by who. participants must be referred to the project within two to four months of injury. 2. age 18 to 60 years at the time of the trauma 3. a rpq score ≥20. 4. able to understand, speak and read danish. 5. living in central denmark region. exclusion criteria: 1. objective neurological findings and/or acute trauma ct scan indicating neurological disease or brain damage. 2. previous concussion leading to persistent pcs within the last two years. 3. severe misuse of alcohol, prescription drugs and/or illegal drugs. 4. psychiatric morbidity or severe neurological disease that impedes participation in the program, i.e. bipolar disorder, autism, psychotic disorder (life time), multiple sclerosis etc.
inspiratory muscle training in patients with stroke in subacute phase.

Conditions: Stroke Rehabilitation

Summary: assess the effect of inspiratory muscle training on lung function, muscle strength and trunk balance in survivors of stroke in the subacute phase of the disease

assess the effect of inspiratory muscle training on lung function, muscle strength and trunk balance in survivors of stroke in the subacute phase of the disease. the intervention will be done in a group of patients who will be treated in the rehabilitation service at the virgen de la arrixaca hospital. they will train using a threshold imt device or a powerbreathe device, to increase their inspiratory muscle strength in addition to a physical therapy treatment. the intervention will last eigtht weeks and the patients will be evaluated at the beginning and at the end of the intervention.

Eligibility criteria:
inclusion criteria: * sroke 6 months before of the beginning of the study * be able to understand simple commands * hemiparesis or hemiplegia * not have serious cardiopulmonary diseases(copd,asthma,bronchiectasis) exclusion criteria: * associated neurological pathology leading to muscle weakness * severe respiratory pathology, pulmonary embolism, presence of tracheostomy cannula, * intracranial hypertension * acute retinal datachment, recent eye surgery * impossibility of labial occlusion * unstable heart disease, unstable angina, aortic aneurysm * recent thoracic or abdominal surgery(6 months) * uncontrolled arterial hypertension

Keywords: stroke respiratory muscles lung stroke rehabilitation
long-term safety and efficacy of imidafenacin in patients with overactive bladder

Conditions: Overactive Bladder

Summary: the purpose of this study is to evaluate the long-term safety and efficacy of imidafenacin.


Eligibility criteria:
inclusion criteria: * men and woman equal or \> 20 years old * patients with urgency, urinary frequency and urgency incontinence exclusion criteria: * patients with genuine stress incontinence * patients suffering from complications such as bladder tumor, urinary tract stone and symptomatic urinary tract infection * patients suffering from complications contraindicating the use of antimuscarinic medication * patients with polyuria

Keywords: imidafenacin krp-197/ono-8025 overactive bladder antimuscarinic
a multicenter randomized trial comparing im nails and plate fixation in proximal tibial fractures

Conditions: Tibial Fractures

Summary: this study looks at two types of surgical treatments and hopes to answer the question: which is the best way to surgically treat a proximal tibia fracture? both procedures being studied are standard of care (used routinely) and use fda approved devices. all medical and surgical treatment will be the same for participants as non-participants.

the study is a multicenter randomized controlled trial in which individuals sustaining a fracture of the proximal metaphysis of the tibia will be operatively managed by one of two strategies. the first strategy involves fixation of the fracture with a reamed, interlocking intramedullary nail (nail group). the second treatment strategy involves open reduction and internal fixation of the fracture with a locking periarticular plate (plate group). the null hypothesis of the study is that there will be no difference in the two groups with respect to the primary and secondary outcome measures. to the degree possible, patients in the two groups will receive post-operative care according to the same standards and protocols.

Eligibility criteria:
inclusion criteria: * skeletally mature, * extra-articular fracture of the proximal tibia extending into the metaphyseal with or without intra-articular extension not requiring open reduction with complete anteroposterior (ap) and lateral radiographs, * major fracture line not closer than 4cm from the proximal tibial articular surface * fracture requiring operative treatment amenable to either im nail or plate * surgeon agreed to randomize patient * informed consent obtained * patient is english speaking exclusion criteria: * tibial shaft fractures not amenable to intramedullary nailing (i.e.fracture is less than 4 cm from joint surface), * fracture of the proximal tibia with intraarticular extension requiring open reduction, * known metabolic bone disease * separate displaced tibial tubercle fragment, * soft tissue injuries compromising treatment method with nail,plate or both. * fractures with vascular injury (gustillo type iiic injury) requiring repair, * compartment syndrome of the leg diagnosed preoperatively, * pathological fractures, * retained hardware or existing deformity in the affected limb that would complicate im nailing,plating or both, * symptomatic knee arthritis. * surgical delay greater than 3 weeks for closed fractures or 24 hours for open fractures, * immunocompromised, * unable to comply with postoperative rehabilitation protocols or instructions (i.e. head injured or mentally impaired), * current or impending incarceration, * unlikely to follow-up in surgeon's estimation.

Keywords: tibia fracture proximal tibia interlocking intramedullary nail locking periarticular plate open reduction internal fixation
effectiveness of telerehabilitation for work-related musculoskeletal disorders in cardiac sonographers

Conditions: Work Related Musculoskeletal Disorders

Summary: work-related musculoskeletal disorders(wrmds) are common among cardiac sonographers due to their nature of work. this study aims to find out the effectiveness of the telerehabilitation method in the management of wrmds among cardiac sonographers. 38 cardiac sonographers diagnosed with wrmds will be randomly allocated into experimental and control groups with an allocation ratio1:1. the experimental group will be receiving the telerehabilitation program along with an ergonomic awareness education program for 6 weeks, and the control group will receive an ergonomic awareness education alone. pain, quality of life and work satisfaction are the outcome measures which will be measured at the baseline and after 6 weeks of the program


Eligibility criteria:
inclusion criteria: * cardiac sonographers with work-related musculoskeletal pain. * cardiac sonographers practicing adult echocardiography predominantly working in public hospitals, private hospitals or/and private outpatient clinics in saudi arabia. exclusion criteria: * systematic diseases as reported by the participants such as diabetes miletus and fibromyalgia. * using cardiac medications or the pain killer as reported by the participants. * any biomechanical abnormalities based on the evaluation of a qualified physical therapist. * any other musculoskeletal disorders or injuries which is not related to wrmds. * any recent surgery which may affect the ability to participate in the exercise program. * any other contraindications to participate in the exercise program. * pregnancy in female participants.

Keywords: work related musculoskeletal disorders cardiac sonographers tele rehabilitation
body-mind-spirit intervention for women with early psychosis

Conditions: Psychosis

Summary: this is an open-labelled randomised controlled trial (rct) that aims to examine the effectiveness of exercise coaching approach in improving the physical activity engagement in patients with psychosis.

patients with psychosis will be recruited from the out-patient department (opd) of the kwai chung hospital (kch). the patient with informed consent will be randomly assigned to exercise coaching or psychoeducation group to prevent decline in cognitive and functional outcomes known to be common in this group. this comprises locally-tested evidence-based intervention strategies such as exercise and yoga intervention, combined with exercise coaching to consolidate the exercise habit. each of the intervention includes 28 sessions spanning for16-week.

Eligibility criteria:
inclusion criteria: * female * age from 18-64 * based on the fifth version of the diagnostic and statistical manual of mental disorders diagnosis to have schizophrenia and related psychotic disorders * have the ability to understand chinese * able to give informed consent * physically fit for participating in our study assessed by using the physical activity readiness questionnaire (par-q) exclusion criteria: * severe physical illness (myocardial infarction, hypertension, fracture, spinal problems in which exercise may be contraindicated), and seizure disorders. * comorbid substance dependence * unstable psychotic symptoms * any history of brain trauma or organic brain disease * known history of intellectual disability or special school attendance * other mental conditions that requires other treatment priorities, e.g., suicidal risk. * other medical conditions that severely limits participation, comprehension, or adherence to the treatment or assessment e.g., epilepsy, dementia, terminal medical illness.
intermittent parasite clearance (ipc) in schools: impact on malaria, anaemia and cognition

Conditions: Malaria; Anaemia

Summary: although the risk of malaria is greatest in early childhood, significant numbers of schoolchildren remain at risk from malaria infection, clinical illness and death. by the time they reach school, many children have already acquired some clinical immunity and the ability to limit parasite growth, and thus most infections are asymptomatic and will go undetected and untreated. asymptomatic parasitaemia contributes to anaemia, reducing concentration and learning in the classroom, and interventions aiming to reduce asymptomatic parasite carriage may bring education, as well as health, benefits. intermittent parasite clearance (ipc) delivered through schools is a simple intervention, which can be readily integrated into broader school health programmes, and may usefully supplement the community-distribution of insecticide-treated nets (itns) in countries with a policy of universal coverage of nets. this study seeks to establish whether intermittent parasite clearance undertaken once a year at the end of the malaria transmission season can reduce malaria parasite carriage and anaemia amongst school-going children already using insecticide-treated nets, and its consequent impact on school attendance and performance, in order to assess its suitability for inclusion as a standard intervention in school health programmes in areas of seasonal malaria transmission.


Eligibility criteria:
inclusion criteria: * enrolled in participating elementary schooled * provision of parental consent exclusion criteria: * lack of consent * chronic conditions which limit regular school attendance * clinical malaria on the day of scheduled treatment (as defined as febrile, with a positive result in a rapid diagnostic test for malaria).

Keywords: malaria anaemia cognition intermittent preventive treatment children schools insecticide-treated nets
safety and efficacy of the ha-based dermal fillers hyaprof® soft and hyaprof® balance

Conditions: Dermal Filler

Summary: purpose of this study is the demonstration of safety and efficacy of the dermal fillers hyaprof® soft and hyaprof® balance for restoration of the facial volume and contour.

this is a prospective, multicenter, observational, open label, two-arm, crossover, pmcf clinical trial for demonstration of the safety and efficacy of the ha-based dermal fillers hyaprof® soft and hyaprof® balance for restoration of the facial volume and contour. besides safety aspects, evaluated immediately after the treatment, 4 weeks, 3 and 6 months after the treatment, the performance of the demal fillers are evaluated in the 3 and 6 months follow-up by using gais and wsrs.

Eligibility criteria:
inclusion criteria: * subjects intended for the treatment with hyaprof® soft and/or balance according to the instructions for use of the product * decision for the treatment with hyaprof® soft and/or balance was made before the subject was recruited for the clinical trial * subjects signed written informed consent * adult subjects at least 18 years old * all fitzpatrick skin types * area treated either with hyaprof® soft or hyaprof® balance - no combination of the products in one treated area exclusion criteria: * tendency to hypertrophic and keloid scarring * intolerance to gram-positive bacteria * prone to active inflammatory or infectious processes * suffering from acute or chronic skin diseases * undergoing anti-coagulant therapy * known allergy to hyaluronic acid * suffering from autoimmune diseases * multiple allergies * pregnancy or lactating women * subjects unlikely to cooperate in the clinical investigation or to comply with the treatment or with the clinical investigation visits

Keywords: volume replacement facial filler soft tissue filler hyaluronic acid
impact of non-pharmacological prevention measures on the incidence of delirium in adult intensive care units

Conditions: Delirium

Summary: the main objective is to evaluate the impact of the "bundle of actions" on the delirium's incidence in resuscitation patients during their stay in the service, compared to a conventional treatment. the investigators therefore hypothesize that a set of coordinated paramedical actions in the prevention of delirium would reduce its incidence by 15% compared to conventional care.

the "bundle of actions" is a coordinated and specific action plan, which has already been validated, focusing on the coordination of wake-up and respiration, the management of delirium, as well as the early mobility of the patient. innovation consists of simple, reproducible nursing care that reduces triggers of delirium; as well as the use of two new approaches in reanimation: conversational hypnosis and early and comprehensive re-empowerment of the patient in the management of his pain and well-being.

Eligibility criteria:
inclusion criteria: * informed consent signed by the trusted person and the patient upon waking * hospitalized in reanimation service (first hospitalization or transfer of another service) * 48 hours of sedation with intubation during hospitalization (all combinations of morphine, hypnotics, sedatives, anesthetics, narcoleptics) * francophone (able to understand all evaluations) criteria for the inclusion of 50 delirium positive patients drawn from the toulouse center (participating in the neuropsychological evaluation): in addition to those mentioned above: * absence of pre-existing cognitive impairment (patients whose relative has completed the iqcode questionnaire and whose score is \<3.4 points) * visual, auditory (authorized equipment) skills and adequate oral or written expression for the proper conduct of neuropsychological tests. exclusion criteria: * pregnant women * evolutive neurological disease leading to cognitive impairment (multiple sclerosis, parkinson's disease, alzheimer's disease), and / or focal neurological disease leading to cognitive impairment (head trauma, stroke, ...) * evolving psychiatric illness (including severe depression) * voluntary drug poisoning * patients who have already participated in the study

Keywords: delirium reanimation conversational hypnosis
quality of life in men undergoing robotic assisted laparoscopic radical prostatectomy versus radical retropubic prostatectomy

Conditions: Prostatic Neoplasms; Quality of Life

Summary: this study is prospective evaluation of quality of life in men undergoing robotic assisted laparoscopic radical prostatectomy versus radical retropubic prostatectomy.

preoperatively, enrolled patients will complete questionnaires called epic that will ask about urinary, sexual, bowel and hormonal function at 1, 3,6,9 and 12 months after surgery, pateints will complete the questionnaires again. all will be enrolled at samsung medical center

Eligibility criteria:
inclusion criteria: * pathologic diagnosis of prostate adenocarcinoma * clinical stage: ajcc (vi) stage t1-t2 n0m0 * primary treatment at samsung medical center for prostate cancer using: radical retropubic prostatectomy, robotic prostatectomy exclusion criteria: * clinical stage: t3, t4, nodal or distant metastasis * all kind of neoadjuvant, concurrent and adjuvant treatment * poor health forced a patient into dropout