Kornimate/medical-research-clean huggingface dataset:
treatment of a single patient with crd-tmh-001

Conditions: Duchenne Muscular Dystrophy

Summary: the study is a single patient study intended to understand the effects of a gene-editing therapeutic to treat a rare mutation of duchenne muscular dystrophy.

the objective of the study is to assess the safety and preliminary efficacy of crd-tmh-001 after intravenous administration for a period of 1 year with long-term follow-up out to 15 years.

Eligibility criteria:
inclusion criteria: * completion of informed consent * confirmation of genetic mutation * confirmation of absence of elevated aav9 nabs exclusion criteria: - any significant medical issue(s) (past or current) that would, in the opinion of the principal investigator (pi), prevent this patient from being dosed.

Keywords: duchenne muscular dystrophy crispr gene-editing
the effects of omega-3 status and supplementation on tendon structure in competitive athletes

Conditions: Tendon Injuries; Inflammation

Summary: the study will examine the association between omega-3 status and the effects of omega-3 supplementation on changes in tendon structure and recovery from tendon injuries and inflammatory markers in competitive athletes. half of the participants will receive omega-3 in combination with vitamin e, while the other half will receive a placebo and vitamin e.

sports injuries are common among athletes, while injury prevention received much clinical attention, there is no consensus among clinicians and researchers as to which injury-causing factors are dominant. it has been suggested that increased training load may be the leading cause of sports injuries, since tendons are sensitive to changes in load, making them vulnerable to injury. inflammation is one of the reversible risk factors to sports injuries, and there are numerous methods which are used to treat inflammation. it has been recently suggested that inflammation reactions are affected by omega-3 status and that omega-3 deficiency may increase the risk of sports and tendon injuries. the omega-3 fatty acid may act as a regulator of membrane structure and function, intracellular signaling pathways, transcription factor activity, and gene expression and reducing inflammation. due to these functions, omega-3 may influence exercise-induced injuries/inflammation in athletes, thus, may influence their health and allowing training.

Eligibility criteria:
inclusion criteria: part one: * training for at least 5 hours per week. * no complaints about lower extremities pains during the last 12 months. part two: * training for at least 5 hours per week. * diagnosed with patellar and achilles tendinitis. exclusion criteria: * underwent lower extremities surgeries. * allergic to fish products. * athletes who use anti-inflammatory drugs and/or omega-3 supplements. * pregnant and/or nursing mothers.

Keywords: omega-3 athletes sports injuries inflammatory markers isokinetic muscle force
effect of co-morbidities on the development of oral feeding ability in pre-term infants

Conditions: Feeding; Difficult, Newborn; Pre-Term

Summary: the aim of this study is to investigate the effect of co-morbidities on the timing of the achievement of full oral feeding in a cohort of pre-term infants and to evaluate their mode of feeding and feeding status at the time of hospital discharge.

it is widely acknowledged that pre-term infants frequently experience difficulties in attaining independent oral feeding, thus delaying the achievement of an adequate nutritional status and hospital discharge which - according to the american academy of pediatrics- requires the ability to feed exclusively by mouth(1-2) the development of oral feeding ability in pre-term infants is therefore a primary concern for neonatologists. because of the immaturity of their body functions and the occurrence of co-morbidities, pre-term infants generally require a period of enteral feeding before they acquire the coordinated sucking ability that allows sufficient milk intake for growth(3) furthermore, infant sucking skills differ between bottle- and breastfeeding (4), and pre-term infants have been reported to show a weaker and less coordinated suck (5). few studies have investigated the timing and effect of co-morbidities on the achievement of independent oral skills. jadcherla et al. (6) reported that infants born with a gestational age of \< 28 weeks showed a significant delay in attaining the transition to oral feeding, but it has also been found that the occurrence of morbidities negatively correlates with postmenstrual age at the time of achieving oral feeding skills (6),(7-8).

Eligibility criteria:
inclusion criteria: 1. a randomised sample of all newborns whose gestational age of \< 37 weeks . 2. infants who will be admitted to the nicu of assiut university children hospital between 1 may and 31 october 2021. exclusion criteria: 1. known congenital and/or chromosomal diseases. 2. death during hospitalisation, or transfer to another institution.
women surviving ovarian cancer

Conditions: Epithelial Ovarian Cancer; Quality of Life; Survivorship

Summary: the purpose of this study is to help us learn more about how women who have had or now have ovarian cancer are doing 5 years or more from their diagnosis. we want to learn about general quality of life, long-term side effects of treatment, sexual function, thinking, memory, and psychological effects (such as anxiety and depression). we will also look at how these women are being followed for ovarian cancer. we hope this study will help us better understand how women surviving ovarian cancer are doing.


Eligibility criteria:
inclusion criteria: * women with invasive epithelial ovarian cancer who are disease-free and 5 to 10 years from diagnosis (for cohort a) and have never experienced a recurrence of epithelial ovarian cancer * women with epithelial ovarian cancer who have had one or more relapses, but are clinically currently disease-free, 5- to 10 years from diagnosis (for cohort b) * women with current evidence of epithelial ovarian cancer who are alive with disease 5 to 10 years from diagnosis (for cohort c) * fluency in english * written informed consent exclusion criteria: * inability to read, communicate in english * ovarian cancer of low malignant potential (borderline tumors)

Keywords: epithelial ovarian cancer quality of life survivorship
potential benefits of laser treatment on skin blood flow and sweating in burn survivors

Conditions: Burn Injury

Summary: the purpose of this study is to examine effects of laser therapy on blood flow and sweating responses in burn-injured skin.

this is a longitudinal study in which the effects of laser therapy on cutaneous vascular responses and sweating of the treated areas are assessed. specifically, burn survivors who will undergo standard of care laser therapy to treat burn-related scars will perform whole-body heating and local heating procedures prior to the initiation of laser therapy, at an intermediate point during the laser therapy regimen, and upon conclusion of the laser therapy regimen. for this pilot investigation a placebo will not be incorporated. primary outcome variables will be skin blood flow and sweating responses from skin treated with laser therapy and adjacent untreated/uninjured skin.

Eligibility criteria:
inclusion criteria: * 18-65 years old * experience a severe burn injury that warrant laser therapy. * free of any significant underlying medical problems based upon a detailed medical history and physical exam exclusion criteria: * known heart disease * other chronic medical conditions requiring regular medical therapy including cancer, diabetes, uncontrolled hypertension, and uncontrolled hypercholesterolemia. * abnormality detected on routine screening suggestive of cardiac ischemia or previously undetected cardiac disease or resting left bundle branch block on screening electrocardiogram. * subject with a body mass index \>35 kg/m2 * pregnant or planning to become pregnant within the subsequent 6 months.

Keywords: laser treatment laser therapy skin blood flow sweating
development of treatments aiming at improvement of function in patients with chronic widespread pain

Conditions: Fibromyalgia

Summary: the study aims to evaluate the effects of adding supervised exercise in supplement to an educational self-management program, and to determine which subgroups would gain effects of the treatment.

164 patients with fibromyalgia and chronic widespread pain were randomized to an exercise-education group or to education-only group. the study period was 20 week. the primary outcome measures comprised the six-minute walk test and the fibromyalgia impact questionnaire. several other self-administered instruments were included.

Eligibility criteria:
inclusion criteria: * women with fibromyalgia or chronic widespread pain, aged from 18 to 60 years. exclusion criteria: * other somatic or psychiatric disorders, inability to understand swedish, allergy to chlorine, ongoing treatments or plans to start other treatments during the study period

Keywords: fibromyalgia chronic pain physical exercise activity education
metanx® p.l.u.s. program (progress through learning, understanding & support)

Conditions: Diabetic Peripheral Neuropathy

Summary: this study will be an observational study in which patients who have been prescribed metanx® are invited to participate in surveys regarding their experiences with metanx®. the purpose of this study is to increase the understanding of the role of metanx® in managing diabetic neuropathy, provide patients with personalized education and support, and contribute to the overall understanding of the needs and concerns of patients being treated for diabetic neuropathy.

surveys used to conduct this study will be administered via telephone or online by infomedics, inc., a company with a system for developing such patient-physician feedback programs. participating physicians will ask their patients to participate in the program after metanx® has been prescribed and provide them with a brochure containing an introduction to the program and instructions on how to enroll. patients self-enroll, take a brief survey before starting their metanx® prescription, and then two brief follow-up surveys at 6 weeks and 12 weeks. as patients complete surveys within the study, their physician will receive individualized feedback reports outlining their patient's treatment experience and progress. patients will also receive a copy of their own reports, to help encourage them to continue taking metanx® as directed. patients will also receive educational materials about managing their diabetic neuropathy.

Eligibility criteria:
inclusion criteria: * new metanx® start * diagnosis of diabetic peripheral neuropathy who have been prescribed metanx® to help metabolic management of endothelial dysfunction. exclusion criteria: * patients who do not meet ada criteria for dpn diagnosis. * if participant indicates that he or she did not get a prescription for metanx®, he/she will not be able to complete the survey(s). * for follow-up surveys, if the participant indicates that he/she has not been taking metanx®, he/she will not be able to complete the survey(s).

Keywords: metanx diabetes neuropathy folic acid folate l-methylfolate vitamin b6 pyridoxal 5'-phosphate vitamin b12 methylcobalamin dpn
identifying expression markers of cumulus cells to identify oocyte developmental potential through a maturation analysis

Conditions: Infertility

Summary: the aim of the study is to analyze the expression of genes and micrornas potentially involved in oocyte competence in follicles of different sizes (\<17mm and ≥17mm) at the time of oocyte pick-up.

in art, one of the major obstacles encountered in some patients is the wide variation in the follicular size at the oocyte pick-up day and consequently, the number of available mature oocytes and the number of competent embryos for implantation. the follicular size at the day of oocyte pick-up reflects the synchronicity of the individual follicular responsiveness to fsh. for successful preimplantation development of an embryo, the oocyte must contain all necessary maternal factors. two of these factors are specific mrna transcripts (gdf9, ptx3, has2, ptgs2, tnfaip6) and microrna (mir-224). for each cumulus oocyte complex, the evaluation of embryo development and morphokinetics will be correlated with the expression and implantation data to identify a quantitative biomarker to predict the embryo with the highest chance of implantation in patients. experimental design: 1. - collection of cumulus oocyte complex (coc) from patients 2. - separation of oocytes according to the size of the follicule they have been retrieved from (\<17mm; ≥17mm) 3. - isolation of mrna from both groups of cumulus cells 4. - expression studies, qrt-pcr (gdf9, ptx3, has2, ptgs2, tnfaip6) 5. - analysis of mir-224, a negative regulator of cumulus expansion via ptx3 6. - time-lapse culture \& evaluation of morphokinetics

Eligibility criteria:
inclusion criteria: * no more than 2 previous treatment cycles * no history of recurrent spontaneous abortions * age ≤ 39 years * bmi \< 30 kg / m2 * ≥ 8 cumulus-oocyte-complexes (coc) retrieved * human chorionic gonadotrophin (hcg) triggering exclusion criteria: * preimplantaion genetic diagnosis (pgd) or preimplantation genetics screening (pgs) indication * maximum number of 24 coc during pickup * failure to culture until day 5 * polycystic ovary syndrome * severe endometrial factor that can influence implantation * uterine malformation or congenital anomaly * severe male factor (azoospermia)
stimulus intensity in left ventricular leads

Conditions: Congestive Heart Failure

Summary: cardiac resynchronization therapy (crt) is a device implanted to improve the function of some people's hearts. crt involves the placement of 3 wires in the heart through a vein near the front of your left or right shoulder into three pumping chambers of the heart, the most important being the left lower chamber, left ventricle (lv).

the purpose of cardiac resynchronization therapy (crt) is to send small amounts of energy (called pacing) through the wires to both the left and right lower chambers of your heart at (or near) the same time. this helps the heart pump in a more coordinated way and send more blood to your body with each beat. how much energy is used for pacing is called the stimulus intensity. increasing the pacing stimulus intensity of the left ventricular wire can lead to an increase in the volume of heart muscle directly stimulated. this has previously been shown to produce beneficial effects on the heart function, like strength of contraction and increased volume of blood pumped. the purpose of this study is to determine if pacing the wires in the left ventricular chamber of the heart using higher stimulus intensity improves the strength of the heart's contraction.

Eligibility criteria:
inclusion criteria: * adults who fulfill approved criteria to receive a cardiac resynchronization device. exclusion criteria: -adults who are unable to give informed consent.

Keywords: cardiac resynchronization therapy congestive heart failure
active clearance technology (act) registry

Conditions: Retained Blood Syndrome

Summary: the purpose of this study is to evaluate the effectiveness of the pleuraflow® active clearance technology™ (act) system in the management of blood evacuation after cardiac surgery.


Eligibility criteria:
inclusion criteria: 1. male or female subjects 18 years of age or older who received a pleuraflow system following heart surgery. 2. patient undergoing cardiac surgery via sternotomy exclusion criteria: 1. robotic surgery 2. any access via thoracotomy 3. any condition deemed inappropriate for inclusion by the investigators. 4. intolerance to implantable silicone materials.
comparison of suturing and packing of drained abscesses

Conditions: Cutanoeus Abscesses

Summary: the standard treatment for skin abscesses in drainage followed by packing to prevent premature closure and reaccumulation of pus. studies from the 1950s and later conducted outside of the us suggest that when drained abscesses are drained and sutured closed they actually heal faster without complications. the current study compares the time to healing and scar formation when drained abscesses are packed or sutured.


Eligibility criteria:
inclusion criteria: * non complicated abscesses exclusion criteria: * fever, * immunocompromise, * cellulitis, * perianal and * pilonidal abscesses

Keywords: abscess, primary closure, secondary closure
preferred consent models for secondary uses of biospecimens among diverse women

Conditions: Biospecimen Donation

Summary: research with stored biospecimens can provide substantial societal benefits, including greater understanding of cancer etiology and discovery of new cancer therapies, but one critical social and ethical issue is the use of samples for research unplanned at the time of biospecimen collection. various models for consent (i.e., no consent, notice, opt-out, broad consent, study-specific consent) have been proposed for secondary research use of biospecimens, but empirical data on individuals' preferences for different consent models are limited, particularly from those with limited health literacy and from racial and ethnic minority groups. it is critically important to understand the consent preferences of diverse individuals, as participation of all population subgroups in biobanks is essential to reach translational cancer research goals. based on a social ecological conceptual framework, the investigators will examine preferences for consent models for secondary research uses of biospecimens among a racially and socioeconomically diverse sample of women 35 years of age and older. the investigators aim to compare experimentally the effect of consent model on intentions to donate biospecimens for future research use among a diverse sample of women. the investigators hypothesize that women will have stronger intentions to donate based on the broad model of consent and the study-specific model of consent compared with the notice model of consent. these findings from groups underrepresented in research will be critical since the participation of these groups in biobanks is essential to generating findings that will achieve translational research goals of eliminating cancer disparities.


Eligibility criteria:
inclusion criteria: * 35 years old or older * proficient in english * identifies as non-hispanic * identifies as african-american or black * identifies as caucasian or white * identifies as female exclusion criteria: * under 35 years old * not proficient in english * identifies as hispanic * identifies as a race other than african-american or black; or caucasian or white * identifies as more than one race * identifies as male

Keywords: biobanks informed consent health literacy
insulin therapy in type 2 diabetic patients: real-life study on effectiveness and satisfaction

Conditions: Diabete Type 2

Summary: diabetes mellitus is an endocrine disorder with heterogeneous etiologies, which is characterized by raised levels of glucose in a person's blood and disturbances of macromolecules such as carbohydrate, fat, and protein metabolism resulting from defects in insulin secretion, insulin action, or both. a lack of insulin, or the inability of cells to respond to it, leads to high levels of blood glucose (hyperglycemia), which is the clinical indicator of diabetes. type 1 dm is characterized by insulin deficiency and a tendency to develop diabetic ketoacidosis, whereas type 2 dm is characterized by variable degrees of insulin resistance, impaired insulin secretion, and excessive hepatic glucose produc tion. diabetes is one of the most rapidly increasing chronic diseases and an important public health problem all over the world. the global burden of diabetes is rising dramatically worldwide. type 2 diabetes is the most common type of diabetes, accounting for around 90% of all diabetes worldwide (idf). the prevalence of type 2 diabetes is high and rising across all regions. this rise is driven by increasing life expectancy, economic development, and increasing urbanization leading to more sedentary lifestyles and greater consumption of unhealthy foods linked with obesity. type 2 diabetes prevalence has increased in egypt during the past few years. egypt is one of the top ten nations with the greatest proportion of adults with diabetes, according to the international diabetes federation. in egypt, the prevalence of diabetes was projected to be 9.6 million, with type 2 diabetes making up the bulk of cases .


Eligibility criteria:
inclusion criteria: -patients with type 2 diabetes mellitus aged ≥18 years. * patients going on insulin therapy versus patients going on oral antidiabetic drugs. * patients included if they met the following criteria: * previous diagnosis of diabetes mellitus or on medical therapy of dm. * no prescription fills for a basal insulin containing product in the 1-year pre index date period; and no prescription fills for bolus insulin or mixed insulin products on index date or in the 1-year pre-index date periods. exclusion criteria: * patients had type 1 diabetes mellitus. * pregnant patients. * incapable of completing the study questionnaires. * were pregnant at any time during the pre-or post-index periods; or * were diagnosed with any other type of diabetes during the study period, including, gestational diabetes , secondary diabetes , or other abnormal glu-cose conditions . * patients who were con-comitantly participating in another trial or receiving insulin treatment for reasons other than t2dm.