axillary block properties in diabetic patients

Conditions: Diabetes Mellitus; Nerve Block Duration; Pain, Postoperative

Summary: background and objectives: the investigators performed this study to explore whether the presence of diabetes mellitus (dm) would affect the outcomes of axillary brachial plexus blocks (abpbs) in patients undergoing elective forearm and/or hand surgery. the primary hypothesis was that the sensory block duration would be delayed in diabetic patients. methods: after obtaining ethics committee approval and written informed consent, 71 patients were enrolled to the study. diabetic patients were included in group dm and non-diabetics were included in group nodm. all received ultrasound-guided abpbs with the mixture of 10 ml lidocaine 2% and 20 ml bupivacaine 0.5%. our primary outcome was sensory block duration, and secondary outcomes were sensory and motor block onset times, motor block duration, time-to-first-pain (numeric rating scale (nrs) ≥4), postoperative nrs scores and rescue analgesic consumption (nrs) ≥4) through the postoperative first 2 days. all outcomes were assessed by a blinded investigators.

background and objectives: the impact of diabetes mellitus (dm) on the practice of peripheral nerve block anesthesia was mostly investigated in animal researches, and effects on human models are required to be clarified. the investigators performed this study to explore whether the presence of dm would affect the outcomes of axillary brachial plexus blocks (abpbs) in patients undergoing elective forearm and/or hand surgery. the primary hypothesis was that the sensory block duration would be delayed in diabetic patients. methods: after obtaining ethics committee approval and written informed consent, 71 patients with american society of anesthesiologists (asa) physical status i-iii and aged between 40 and 75 years were enrolled to the study. diabetic patients were included in group dm and non-diabetics were included in group nodm. all received ultrasound-guided abpbs with the mixture of 10 ml lidocaine 2% and 20 ml bupivacaine 0.5%. postoperatively, patients were administered paracetamol as rescue analgesics, if numeric rating scale (nrs) was ≥4. our primary outcome was sensory block duration, and secondary outcomes were sensory and motor block onset times, motor block duration, time-to-first-pain (numeric rating scale (nrs) ≥4), postoperative nrs scores, and rescue analgesic consumption (nrs) ≥4) through the postoperative first 2 days. all outcomes were assessed by a blinded investigators.

Eligibility criteria:
inclusion criteria: patients scheduled for elective forearm and/or hand surgery american society of anesthesiologists (asa) physical status i-iii no regional anesthesia contraindication exclusion criteria: type 1 dm type 2 dm patients with only 'diet-controlled' therapy difficulty with understanding the block and follow-up instructions significant neurologic disorders psychiatric or cognitive disorders history of substance abuse acute and/or chronic opioid use local anaesthetic hypersensitivity or allergy

Keywords: diabetes mellitus axillary brachial plexus block block duration time-to-first pain postoperative analgesia