testing the addition of the drug relugolix to the usual radiation therapy for advanced-stage prostate cancer, the nrg promethean study

Conditions: Oligometastatic Prostate Carcinoma; Prostate Adenocarcinoma; Prostate Ductal Adenocarcinoma; Prostate Intraductal Carcinoma; Stage IVB Prostate Cancer AJCC v8

Summary: this phase ii trial compares the usual treatment of radiation therapy alone to using the study drug, relugolix, plus the usual radiation therapy in patients with castration-sensitive prostate cancer that has spread to limited other parts of the body (oligometastatic). relugolix is in a class of medications called gonadotropin-releasing hormone (gnrh) receptor antagonists. it works by decreasing the amount of testosterone (a male hormone) produced by the body. it may stop the growth of cancer cells that need testosterone to grow. radiation therapy uses high-energy x rays or protons to kill tumor cells. the addition of relugolix to the radiation may reduce the chance of oligometastatic prostate cancer spreading further.

primary objective: i. compare conventional radiological progression-free survival (rpfs) for positron emission tomography (pet)-detected, biochemically recurrent, oligometastatic, castration-sensitive prostate cancer patients treated with stereotactic ablative body radiation therapy (sabr) plus placebo versus (vs.) sabr plus relugolix. secondary objectives: i. compare conventional or pet-based radiological progression-free survival (prpfs) between treatment arms. ii. compare patient-reported sexual and hormonal quality of life as assessed by corresponding expanded prostate cancer index composite short form (epic-26) domains between treatment arms. iii. compare other measures of quality of life obtained from the european quality of life five dimension five level scale questionnaire (eq5d-5l), european organization for research and treatment of cancer (eortc) quality of life questionnaire core 30 (qlq-30), patient reported outcomes measurement information system (promis) fatigue instruments between the two treatment arms. iv. compare time to salvage therapy and time to castration-resistance between treatment arms. v. compare local progression (sabr-targeted lesion), biochemical progression, distant metastases, prostate cancer-specific mortality, metastasis-free survival, and overall survival between treatment arms. vi. determine adverse events rates and compare rates between the two treatment arms. exploratory objective: i. evaluate genomic and peripheral tissue and blood markers of treatment response. outline: patients are randomized to 1 of 2 arms. arm i: patients receive placebo orally (po) once daily (qd) on days 1-180 and undergo sabr for 1-3 weeks in the absence of disease progression or unacceptable toxicity. arm ii: patients receive relugolix po qd on days 1-180 and undergo sabr for 1-3 weeks in the absence of disease progression or unacceptable toxicity. patients may also undergo bone scan, computed tomography (ct), magnetic resonance imaging (mri), prostate-specific membrane antigen (psma) positron emission tomography (pet)/ct or pet/mri, and/or fluciclovine f18 pet/ct or pet/mri at time of disease progression. patients may optionally undergo urine and blood sample collection throughout the trial. after completion of study treatment, patients are followed up at 9 and 12 months, subsequently every 6 months to month 60, and then annually thereafter or at the time of progression.

Eligibility criteria:
inclusion criteria: * pathologically (histologically or cytologically) proven diagnosis of prostate adenocarcinoma at any anatomical location (for example, prostate, metastatic site), including intraductal or ductal carcinoma, at any time before registration * age \>= 18 years * eastern cooperative oncology group (ecog) performance status 0-2 within 180 days prior to registration * prior curative-intent treatment to the prostate, by either: * external beam and/or brachytherapy to: prostate alone, prostate and seminal vesicles, prostate and pelvic nodes, or radiation to all three sites * radical prostatectomy alone, radical prostatectomy plus postoperative radiotherapy to the prostate bed, or radical prostatectomy plus postoperative radiotherapy to the pelvic nodes. * note: patients who have received curative intent with radiation prior to prostatectomy are eligible and should be categorized as rt to intact prostate since that was the first curative intent * must meet study entry criteria based on the following diagnostic workup within 120 days prior to registration: * history and physical examination; * fluciclovine or psma pet scan; * pet must be combined with either ct or mri, but a diagnostic ct or mri reading/interpretation is not required * 1 - 5 oligometastatic lesions in bone and/or nodal/soft tissue (non-abutting nodes are counted separately) sites on fluciclovine or psma pet within 180 days prior to registration and includes at least one of the following: * bone - each metastasis is counted (for example, 2 distinct lesions in the right ilium count as 2 oligometastatic lesions) * extrapelvic nodal/ soft tissue - requires at least one extrapelvic inguinal or a nodal/soft tissue lesion superior to the iliac bifurcation (that is, american joint committee on cancer \[ajcc\] m1a version 8) * note: although a patient must have bone and/or extrapelvic disease to be eligible, when counting the number of oligometastatic lesions, each lymph node lesion, whether pelvic or extrapelvic, is counted (for example, 2 distinct lymph nodes in the right external iliac basin count as 2 oligometastatic lesions; one extrapelvic and one pelvic node count as 2 oligometastic lesions, etc) * serum total prostate-specific antigen (psa) =\< 10.0 ng/ml that also meets one of the following psa recurrence definitions: * if patient has received-radiation therapy to intact prostate, either * psa \> post-rt nadir psa + 2 ng/ml obtained within 180 days prior to registration, or * psa \> 0.2 ng/ml with at least two rises from post-treatment nadir with the most recent psa within 180 days prior to registration * if patient has received a radical prostatectomy with or without post-op rt, either * current psa \> 0.2 ng/ml, with a second confirmatory psa \> 0.2 ng/ml, with most recent psa obtained within 180 days prior to registration, or * two consecutive psa rises from post-operative nadir, with most recent psa obtained within 180 days prior to registration * must have \>= 3 psa values within the last two years since end of primary treatment or within the last 2 years prior to registration, whichever is less * note: psa doubling time must be calculated by entering all psa values since end of primary treatment or within the last 2 years prior to registration (whichever is less) into the psa doubling time calculator found at mdcalc.com * serum total testosterone \>= 100 ng/dl within 180 days prior to registration * note: prior androgen deprivation therapy (other than bilateral orchiectomy) is allowed if discontinued prior to registration and serum total testosterone is \>= 100 ng/dl * total bilirubin: =\ 1.5 x uln, subject is eligible if direct bilirubin is =\< 1.5 x uln) (within 180 days prior to registration) * aspartate aminotransferase (ast) (serum glutamic oxaloacetic transaminase \[sgot\]) and alanine aminotransferase (alt) (serum glutamic pyruvic transaminase \[sgpt\]): =\< 2.5 x institutional uln (within 180 days prior to registration) * for patients with evidence of chronic hepatitis b virus (hbv) infection, the hbv viral load must be undetectable on suppressive therapy, if indicated * note: known positive test for hepatitis b virus surface antigen (hbv sag) indicating acute or chronic infection would make the patient ineligible unless the viral load becomes undetectable on suppressive therapy. patients who are immune to hepatitis b (anti-hepatitis b surface antibody positive) are eligible (e.g. patients immunized against hepatitis b) * patients with a history of hepatitis c virus (hcv) infection must have been treated and cured. for patients with hcv infection who are currently on treatment, they are eligible if they have an undetectable hcv viral load * note: known positive test for hepatitis c virus ribonucleic acid (hcv rna) indicating acute or chronic infection would make the patient ineligible unless the viral load becomes undetectable on suppressive therapy * human immunodeficiency virus (hiv)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial * the patient must agree to use a highly effective contraception (even men with vasectomies) if he is having sex with a woman of childbearing potential or with a woman who is pregnant while on study drug and for 2 weeks following the last dose of study drug * the patient or a legally authorized representative must provide study-specific informed consent prior to study entry and, for patients treated in the united states (u.s.), authorization permitting release of personal health information exclusion criteria: * currently on androgen deprivation or anti-androgen therapy * spinal cord compression, or spinal intramedullary, brain, and/or visceral (for example liver, etc.) metastasis * note: spinal metastases (pet-detected) with epidural extension are eligible if there is \> 0.3 cm spatial separation between the gross tumor volume and spinal cord. lung metastases are eligible * biopsy-proven prostatic carcinoma with signet-ring, sarcomatoid, or neuroendocrine features (for example, small cell) * prior metastatic or non-metastatic, invasive malignancy (except non metastatic, non-melanomatous skin cancer) unless continuously disease free for \>= 3 years * prior chemotherapy for prostate cancer or bilateral orchiectomy * note: prior chemotherapy for a different cancer is allowed if continuously disease-free for \>= 3 years * prior high dose radiotherapy to a lesion (i.e. oligometastatic recurrence by pet) * note: lesions included in or near a previously irradiated planning target volume (ptv) are eligible as long as previous delivered dose is estimated to be less than an eqd2 of 50 gy * inability to treat all oligometastatic sites with radiotherapy in the judgement of the investigator * intrapelvic lymph nodes as only site of prostate cancer recurrence * inability to swallow whole, undivided, unchewed, and uncrushed pills * known gastrointestinal disorder affecting oral medication absorption * co-morbidity defined as follows: * patients with any comorbidities that would prohibit completion of protocol specified therapy * inflammatory bowel disease in patients in whom abdominopelvic radiotherapy is planned * history of congenital long qt syndrome * current severe or unstable angina * new york heart association functional classification iii/iv heart failure (note: patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the new york heart association functional classification)