Kornimate/medical-research-clean huggingface dataset:
hospitalized children and adolescent patients with type 1 diabetes during the covid-19 pandemic in egypt

Conditions: Type 1 Diabetes; Covid19

Summary: although reports showed that children with well controlled diabetes do not appear to have increased risk of infection with sars-cov-2, however data are scarce regarding the extent to which clinical and demographic data of patient could modify the outcome and severity of the disease. additionally, the link between covid-19 and diabetes remains controversial.

data from poorly controlled patients with type 1 diabetes remains controversial regarding whether diabetes itself could increases the susceptibility of infection with sars-cov-2 and subsequently impacts the outcomes in these patients , or the sars-cov-2 subsequently affects the risk of type 1 diabetes and increase in the prevalence of severe dka. poorly controlled diabetes and chronic hyperglycemia creates a state of low grade chronic inflammation, which may explain the underlying mechanism of increased susceptibility to infection and infer the outcome in patients with diabetes . poorly controlled diabetes has been linked to multiple derangements of immune system including inhibition of lymphocyte proliferation in response to different stimuli, as well as impaired monocyte/macrophage function together with increased synthesis of pro-inflammatory cytokines and adhesion molecules that mediate tissue inflammation . few data links the association between development of diabetic ketoacidosis in patients with covid-19, where the infection could trigger higher stressful conditions, with the release of stress hormones leading to increased blood glucose levels and abnormal glucose variability . the extent to which clinical and demographic data of patients with type 1 diabetes modifies the outcome and severity of the disease seems entirely unclear and is the question of several researches. • study tools: all patients admitted to pediatrics hospital, ain shams university in the period between may to august 2020 will be subjected to: 1- detailed history 2. thorough clinical examination: to assess the inclusion and exclusion criteria. a thorough clinical review to assess organ involvements and clinical and laboratory characteristics as well as the outcome measures in the studied cohort. 3. data collection: demographic and data will be extracted from patients inpatient files and reports

Eligibility criteria:
inclusion criteria: * all patients with type 1 diabetes admitted to pediatrics hospital, ain shams university in the period between may to july 2020. * age: less than 18 years old. exclusion criteria: • children with other forms of diabetes, including: type 2, monogenic forms and secondary diabetes

Keywords: type 1 diabetes covid 19 diabetic ketoacidosis
evaluation of a psychoeducational intervention for people with suicidal behaviour in the penitentiary environment. n'viu project

Conditions: Suicide

Summary: objective. the main objective is to determine the effectiveness of a psychoeducational program conducted by rehabilitation professionals to reduce the number of suicidal behaviors in prisons. methodology. the design of the study will be a multicenter, randomized, two-group clinical trial with blind evaluation of response variables, one year follow-up. the study population will be a male and female prison population of a total of two catalan prisons. as a dependent or outcome variable, the total number of suicidal behaviors recorded for 12 months after the intervention will be determined. as independent variables, socio-demographic, clinical and prison situation variables will be collected. the suicidal ideation will be measured with the columbia-suicide severity rating scale (c-ssrs). the anxiety and depression with hamilton scale for assessing anxiety (hdrs) and the hamilton scale for assessing severity of depressive symptoms (ham-d). the euroqol-5d health questionnaire (eq-5d) to measure quality of life. and a satisfaction survey of psychoeducational group intervention. participants who meet the inclusion criteria will be divided into two groups, an intervention group that will conduct group sessions with a frequency of two per week and duration of 90 minutes for a total of 13 sessions, and a control group that will receive information on suicide counseling. discussion. mortality from suicide is higher in the prison population than in the general population. this project aims to evaluate the effect of a psychoeducational intervention on reducing the number of suicidal behaviors in prison, in order to evaluate their implementation at the level of the entire prison network.


Eligibility criteria:
inclusion criteria: -people who have attempted suicide or a risk of suicide moderate to high. exclusion criteria: * people with a mental disorder in a state of acute exacerbation * intellectual disability * cognitive impairment
effectiveness of tai chi on cardiac autonomic function and symptomatology in women with fibromyalgia: a randomized controlled trial

Conditions: Fibromyalgia

Summary: fibromyalgia (fm) is an idiopathic disease affecting approximately 3% of the world population, primarily diagnosed in middle-aged women. although fm is mainly characterized by chronic pain and fatigue, reduced muscular strength and flexibility are common symptoms associated with the presentation of the disorder. interestingly, the etiology and underlying mechanism of fm are not completely understood, but previous findings suggest that autonomic dysfunction may explain some of the fm symptoms. compared to age-matched healthy individuals, patients with fm have an attenuated autonomic function which is associated with a reduction in vagal tone and increase in sympathetic activity. therefore, autonomic function is a worthwhile target intervention in individuals with fm. although traditional exercise ( both aerobic and resistance) has been shown to effectively improve hrv parameters and fm symptoms, most fm patients display a decline in adherence to traditional exercise and continue to experience considerable pain and fatigue years after the original diagnosis ultimately requiring medication to control their symptoms.thus, new approaches are needed to improve autonomic function and clinical symptoms in patients with fm, which will ultimately improve their physical and emotional functioning leading to a better quality of life. tai chi (tc) is a form of ancient chinese martial art which integrates slow movements, controlled breathing and mental concentration. tc training is safe for special populations and has previously shown to decrease pain, fatigue as well as other fm related symptoms.however, the potential role of tc training on autonomic function is largely unexplored. the investigators hypothesis is that 12 weeks of tc training would improve our primary outcome of autonomic function through improvements in sympathovagal balance, and the secondary outcomes measures of fm symptoms (pain, fatigue and sleep quality), strength and flexibility.

the purpose of this study is to examine the effects of 12 weeks of tc training on on cardiac autonomic function, fm symptoms (pain, fatigue and sleep quality), strength and flexibility. the specific aim of the study is: - to evaluate the effects of 12 weeks of tc training on autonomic function arterial function by assessing heart rate variability

Eligibility criteria:
inclusion criteria: * fibromyalgia * sedentary exclusion criteria: * known pulmonary, cardiovascular, renal, adrenal, pituitary, severe psychiatric or thyroid diseases. * use of hormone replacement therapy during the 6 months prior to the study. * any medication changes in the previous 12 months. * current participation in psychological or physical therapy * history of steady exercise or received exercise training in the last year
phase i study of pn401, fluorouracil, leucovorin and cpt-11 in patients with solid tumors

Conditions: Solid Tumors

Summary: cpt-11 and 5fluorouracil (5fu) combined with leucovorin has become the standard of care for colorectal cancer. pn401 permits treatment with higher than normal doses of 5fu, which could increase its therapeutic potential. it is hypothesized that adding pn401 to the cpt-11, 5fu, leucovorin regimen will reduce toxicity and will allow higher doses of 5fu to be well tolerated and therefore potentially increase effectiveness.


Eligibility criteria:
inclusion criteria * must be at least 18 years of age; * life expectancy: at least 3 months; * performance status: ecog of 0 or 1; * histologic or cytologic proof of a solid tumor cancer that is not amenable to curative surgical resection; * evaluable or measurable disease documented within 4 weeks of the start of treatment; * prior chemotherapy or radiotherapy is allowed if 4 weeks or more have elapsed prior to starting treatment and patients have recovered from toxicities of prior treatment; * adequate organ function: hematopoietic: anc = 1500/ul or more, platelets = 100,000/ul or more, hemoglobin = 9.5 g/dl or more, transfusion prior to evaluation is allowed; hepatic: bilirubin = 2.0 mg/dl or less and sgpt(alt) and sgot(ast) \< 3 x upper limit of normal (\< 5 x upper limit of normal if liver metastases present) renal: serum creatinine \< 2.0 mg/dl; * patient has the initiative, geographic proximity, and means to be compliant with the protocol; * fertile patients (male or female) must agree to use effective contraception; * must be able to swallow and retain tablets. exclusion criteria * major surgery within the four weeks preceding the start of treatment; * serious medical or psychiatric illness that would prevent self-determined informed consent; * intensive chemotherapy treatment; * infection or antibiotics at the time of screening; * uncontrolled cardiovascular, pulmonary, renal, neurologic, psychiatric, or hepatic dysfunction; * pregnant or nursing; * pre-existing diarrhea or uncontrolled clinically significant illness other than cancer (i.e. ulcerative colitis, malabsorption syndrome); * brain metastases that have not been stable for more than 3 months; * known dihydropyrimidine dehydrogenase (dpd) deficiency.

Keywords: colorectal cancer gastric cancer breast cancer
the effect of cold spray applied before local anaesthesia

Conditions: Pain; Anxiety; Coronary Artery Disease

Summary: coronary angiography is a reliable and valid method used in the diagnosis of coronary artery disease (cad). coronary angiography is defined as the process of obtaining cineangiographic images by administering radio-opaque material to the coronary vessels via arterial route. coronary angiography is frequently performed from brachial, radial and femoral arteries. the aim of coronary angiography is to determine the presence, localisation and extent of cardiovascular lesions. invasive interventions cause anxiety and pain in the patient, increase the level of anxiety and cause a number of negative effects such as increased use of sedative drugs, development of post-procedure complications, prolongation of the recovery process and hospitalisation time. it is stated that there is a positive relationship between reducing the anxiety of the patients and meeting the needs of the patients.


Eligibility criteria:
inclusion criteria: * being between the ages of 18 and above. * not having used any anesthetic substance before the procedure. * not having undergone angiography before. * having no communication problems. exclusion criteria: * having previously undergone angiography. * having taken analgesics before angiography.

Keywords: pain, anxiety, cold spray, angiography
study to evaluate bone and gum dimension changes around dental implants placed in different positions in bone.

Conditions: Mouth, Edentulous

Summary: the purpose of this study is to test two standard of care techniques of placing dental implants, and to compare how people's bones and gums respond to two different depths at which implants are placed.

the purpose of this study is to test epicrestal and subcrestal placement of dental implants, and to compare how people's bones and gums respond to two different depths at which implants are placed.

Eligibility criteria:
inclusion criteria: 1. subjects must have read, understood and signed an informed consent form; 2. subjects must be 18 to 70 years of age; 3. subjects must be able and willing to follow study procedures and instructions; 4. subjects must have indication to receive two implants in a bilateral maxillary or mandibular edentulous areas (for at least 4 months post extraction) in areas of pre-molars (first or second) and molars (first or second); 5. sufficient width and height of bone to place at least 8mm length and any compatible in diameter ankylos implant; 6. sufficient vertical clearance to place a single tooth crown replacement; 7. no apical disorder/inflammation at the area of the implant site. exclusion criteria: 1. subjects participating in other clinical studies within 1 month prior to screening and/or involving therapeutic intervention (either medical or dental) that could affect bone or soft tissue healing; 2. female subjects who are pregnant or lactating, or who intend to become pregnant during the study period following entrance into the study; 3. subjects with parafunctional habits; 4. subjects who have failed to maintain good plaque control; 5. subjects with any systemic condition like uncontrolled diabetes mellitus, cancer, hiv, disorders that compromise wound healing, chronic high dose steroid therapy, bone metabolic diseases, radiation or other immuno-suppressive therapy which would preclude periodontal surgery; 6. absence of occlusal stability in centric occlusion; 7. subjects with the presence of acute infectious lesions in the areas intended for surgery; 8. history within the last 3 months of weekly or more frequent use of smokeless chewing tobacco, pipe or cigar smoking and cigarette smoking (greater than 10 cigarettes per day) 9. present alcohol or drug abuse; 10. angulation requirements of the restoration exceeding approximately 15 degrees; 11. systemic corticosteroids or any other medication that would compromise post-operative healing and/or osseointegration (e.g. calcium channel blocker, dilantin).
evaluation of the quantiferon-tb test.

Conditions: Tuberculosis

Summary: to compare the results of the investigational test to the currently approved quantiferon-tb gold in-tube test.

to compare the sensitivity of the cst001 assay to the quantiferon-tb gold assay in patients with bacteriologically confirmed and untreated tb disease.

Eligibility criteria:
inclusion criteria: * clinical symptoms consistent with a high probability of having tb disease * receiving, or are likely to receive, therapy for active tb * confirmed tuberculosis by either afb smear and culture testing, or nucleic acid amplification methods and culture testing. * between 18 and 70 years of age. exclusion criteria: * taken therapy for active tb or latent tb for more than 14 days * culture confirmation of m. tuberculosis not obtained

Keywords: tuberculosis tb
measuring changes in acute pain in the emergency department using patient reported scales

Conditions: Acute Pain

Summary: patient reported pain, stress, and anxiety measures have been found to be inter-related, but it is not known if they are all associated with receiving opiate medications. the objective of this study is to determine if patients' degree of reported pain, stress, or anxiety is associated with receiving opiate pain medications in the emergency department or at discharge. alert patients at least 18 years of age and who report pain greater than 3/10 are eligible to participate in the study. consenting patients complete visual analog scales describing their perceived pain, stress, and anxiety from enrollment until discharge. demographic data and administration of pain medication is also recorded. visual analog scale scores among patients who received an opioid pain medicine in the emergency department and at discharge will be compared to those who did not.


Eligibility criteria:
inclusion criteria: * reported pain greater than or equal to 3 out of 10 exclusion criteria: * less than 18 years of age * decreased level of consciousness * inability to answer questions * prisoner

Keywords: pain pain measurement visual analog scale anxiety stress opioid emergency department demographics
multiple instrumentation for acl reconstruction regarding bacterial contamination

Conditions: Anterior Cruciate Ligament Injuries

Summary: to determine the effect of multiple instrumentation regarding bacterial contamination in transportal and transtibial techniques in acl reconstruction .a randomized controlled study

infection is a catastrophic and one of the most dreaded complications in orthopaedic surgery. several measures have been undertaken to reduce the risk of infection, one of which is the use of systemic prophylactic antibiotics. the purpose of this study is to determine the effect of multiple instrumentation regarding bacterial contamination in transportal and transtibial techniques in acl reconstruction . about eighty consecutive patients having surgical indication for acl-r will be included, the cases will be divided into two groups, 35 cases will undergo for the transtibial technique and the other 45 cases will undergo for the transportal technique. after preparation, swabs will be obtained from subcutaneous tissue at antromedial portal track in transportal technique (femoral tunnel drilling) and in transtibial technique before and after the instrumentation and femoral screw insertion, a control sample will be taken at antrolateral track in both techniques, then samples will be sended to the lab to be studied.

Eligibility criteria:
inclusion criteria: 1. isolated acl injury. 2. non deformed knee. exclusion criteria: 1. associated knee injury (eg. pcl). 2. deformed knee ( eg. genu varus , genu valgus more than 4 degree ) 3. patient with medical history of being immune compromized patient eg,dm
althera® versus nutramigen / cow's milk intolerance

Conditions: Allergy

Summary: the primary objective of this study is to demonstrate that althera® is equal or superior in efficacy than nutramigen®


Eligibility criteria:
inclusion criteria: * infants from few days of life until 6 months of age * birth weight : between 2.500g and 4.500g * full term: gestational age between 37 and 42 weeks * singleton birth * suspicion of a mild/moderate cow's milk proteins intolerance (cmpi) * having obtained the informed consent by the parents or the legal guardian exclusion criteria: * exclusive breastfeeding at time of enrolment * having been treated before enrolment with an extensively hydrolysed formula * disease impairing a normal gut transit (like pyloric stenosis) * intolerance to lactose (if already known) * receiving an antibiotic treatment at the time of enrolment * severe or chronic diarrhea * failure to thrive * neurologic diseases * receiving a medical treatment which could interfere with the protocol or after a surgical intervention * infants whose parents / caregivers who cannot be expected to comply with treatment * currently participating or having participated in another interventional clinical trial
early versus late initiation of feeding in premature growth restricted newborns with absent or reversed end diastolic flow on umbilical artery doppler (aredf)

Conditions: Prematurity of Fetus; Postnatal Growth Disorder

Summary: the purpose of the study is to compare early versus late initiation of enteral feeding in premature growth restricted babies below the gestational age of 35 weeks born to mothers with prenatal absent or reversal of end diastolic flow in the umbilical artery. normally the blood flow from the mother to the baby brings all the nutrients required for growth and the very vital oxygen required for survival. these deprived babies with poor blood flow adapt to the not so conducive uterine environment by certain adjustments in blood supply to internal organs. this permits the best possible blood flow to brain heart etc., which are the vital organs and whose adequate functioning is required for survival. as a consequence, the gut (intestines) gets poor blood supply and hence its appropriate functioning may be jeopardized. such 'premature growth restricted' babies are at increased risk of further growth faltering if not fed adequately as also to a condition called 'necrotising enterocolitis' if fed liberally like other healthy neonates, characterized by abdominal distension, blood in stools and inability to feed for longer durations thereby further affecting growth. in the past such babies (after birth) were not fed for days together which compromised their growth even further. it is not clear whether continuing to withhold feeds for prolonged duration will prevent nec but lead to growth faltering and initiating feeds early will potentiate nec with further compromised growth and increased morbidity. there are no randomized trials on feeding strategies in this group of neonates and hence the investigators planned to carry out this study on comparison of early versus delayed initiation of feeding in preterm sga infants with aredf.


Eligibility criteria:
inclusion criteria: 1. preterm neonates below 35 weeks gestation born at the study center(s) 2. small for gestational age (sga) ie weight \< 10th centile for gestation 3. absent or reverse end diastolic flow (aredf) in umbilical artery exclusion criteria: 1. babies with major congenital malformations. 2. babies with severe asphyxia as defined by apgar score \<4 at 5 min of life with cord/within one hour of life ph\< 7.0. 3. shock requiring pressor support at the time of randomization. 4. babies born with gastrointestinal surgical conditions precluding enteral feeding. 5. babies with abdominal distension, bilious or hemorrhagic aspirates or recurrent vomiting at the time of randomization. 6. refusal to obtain consent. 7. gestation below 26 weeks. 8. hydrops fetalis.

Keywords: preterm sga aredf early feeding late feeding feed intolerance necrotizing enterocolitis days to achieve full feeds defined as 150 ml/kg