Kornimate/medical-research-clean huggingface dataset:
combined electromagnetic field and a plantar resistance exercise with venous leg ulcer

Conditions: Venous Leg Ulcer

Summary: the purpose of this study will investigate the effects of combined electromagnetic field and a plantar resistance exercise therapy versus electromagnetic field on healing of venous leg ulcer .


Eligibility criteria:
inclusion criteria: patients with venous leg ulcer exclusion criteria: patients who have one or more of the following conditions: * peripheral vascular disease (pvd), (abpi\<0.8). * venous leg ulcers with cellulitis or infection symptoms, as well as venous leg ulcers with necrotic tissue or slough or had more than one ulcer. * other types of ulcers, such as rheumatoid vasculitis, diabetic foot, and malignant ulceration; corticosteroids use ; patients with dementia or who were disoriented; * undertaken another physical therapy modality for ulcer healing.
lithium, cord blood cells and the combination in the treatment of acute & sub-acute spinal cord injury

Conditions: Spinal Cord Injury

Summary: the trial is to investigate the safety and efficacy of oral lithium, intraspinal umbilical cord blood mononuclear cell transplant, and the combination in the treatment of acute and subacute spinal cord injury


Eligibility criteria:
inclusion criteria: * either gender and 18-65 years old; * acute or subacute traumatic spinal cord injury (defined as sci resulting from an exteneral non-penetrating cause that occurred within 4 weeks); * neurological status of asia a; * neurological level between c5-t11; * mri shows injury site is within 3 vertebral level and necrotic focus, if exist, is less than 1/3 of the spinal cord diameter; * professional judgment determinate that subjects need a spinal decompression surgery; * subjects able to complete neurological examination; * subjects have voluntarily signed and dated an informed consent form. exclusion criteria: * penetration sci such as gun-shoot, knife-cutting or sci caused by non-traumatic conditions; * spinal cord lesion exceeds three segments or necrotic focus with diameter larger than 1/3 of the spinal cord; * severe complications; * significant medical diseases or infection; * pregnant or lactating woman, or female of childbearing potential and who is unwilling to use an effective contraceptive method while enrolled in the study; * unavailability of suitable umbilical cord blood cells; * contraindication of lithium carbonate and/or spinal decompression surgery * subject is currently participating in another study or has been taking any investigational drug within the last 4 weeks prior to screening; * investigator suggests that the subject would not be suitable to participate this study

Keywords: spinal cord injury umbilical cord blood cell cell transplant lithium carbonate
protocol for self-compassion intervention for teens with diabetes type 1 and their caregivers

Conditions: Diabetes type1

Summary: the goal of this study is to examine the feasibility and potential effectiveness of a short (4 sessions) self-compassion intervention for adolescents with t1d and their caregivers on psychological, metabolic, and behavioral outcomes.

type 1 diabetes (td1) has a significant impact on individuals dealing with this chronic metabolic condition, their families and the whole society. a particularly vulnerable group of individuals with td1 are adolescents. the investigators created a short (4 sessions) self-compassion intervention for adolescents with t1d and their caregivers. both feasibility and potential clinical effectiveness will be assessed using a single-case, multiple baseline experimental design where psychological, behavioral, and metabolic outcomes will be evaluated at baseline, post intervention, and 3- and 6-months follow ups. moreover, ecological momentary assessment will be performed daily.

Eligibility criteria:
inclusion criteria for the caregivers: * have taken care of the management of the patient with diabetes for at least one year since the day of recruitment * they have access to a personal mobile phone. inclusion criteria for the patients/teens: * aged 11-15 years old * diagnosed with t1d more than 12 months ago at the time of recruitment * they have access to a personal mobile phone. general exclusion criteria: * non-spanish native speakers * presenting developmental or attention deficit disorders (e.g., autism spectrum disorder, adhd) * being diagnosed with a serious mental disorder requiring ongoing treatment (e.g., psychosis) or receiving a pharmacological intervention (e.g., depression, anxiety). exclusion criteria for teens: * untreated hypothyroidism * recently (in previous 48 hours of the recruiting process) diagnosed with (a) diabetic ketoacidosis (dka) or (b) severe hypoglycaemia.
evaluating use of topical imipramine and amitriptyline in reducing ultraviolet b light-induced redness in patients with rosacea

Conditions: Rosacea

Summary: rosacea is a common skin condition associated with easy blushing and red face; many patients with rosacea react to sunlight with increased redness. the purpose of this study is to determine if the use of a topical medication will help reduce sunlight induced redness and irritation in patients with rosacea.


Eligibility criteria:
inclusion criteria: * fitzpatrick skin type i - iiii * self-identified rosacea or no history of flushing/blushing for controls * able to provide medical history and list of medications -- control subjects will not be allowed to take medications that are known to be photosensitizers. exclusion criteria: * using imipramine, amitriptyline or any other tricyclic antidepressant (oral or topical) * using topical anti-inflammatory (within 1 week) or systemic agents (e.g. prednisone) * large tattoos in the designated testing areas * tanning bed use within last 3 months * photodynamic therapy or ucb treatments in past 3 months * female subjects: pregnant or nursing
evaluation of renalguard® system to reduce the incidence of contrast induced nephropathy in at-risk patients

Conditions: Contrast Induced Nephropathy

Summary: contrast-induced nephropathy (cin) can occur when patients with pre-existing kidney problems undergo procedures that use iodinated contrast media, such as cardiac catheterizations. renalguard therapy was developed to enable the patient to clear the contrast out of their kidney before it can do significant damage. this study aims to enroll patients with increased risk of developing cin who are scheduled for a cardiovascular catheterization. patients will be randomized to either renalguard therapy or standard therapy.


Eligibility criteria:
inclusion criteria: * male or non-pregnant female equal or greater than the age of 18 years old and is able to provide informed consent. * subject is scheduled to undergo an elective catheterization procedure * hemodynamically stable * at increased risk of developing cin * subject has agreed to all follow-up testing. exclusion criteria: * class 4 congestive heart failure (chf)or a documented left ventricular ejection fraction \< 30% * is anuric or has undergone renal replacement therapy within the past month, or has a known inability to have a foley catheter placed. * subject has been hospitalized or treated medically for any change in renal function over the past week (i.e. dialysis, etc.), or a significant change in renal function is noted at time of screening. * has documented severe aortic stenosis.(note: subjects who have undergone successful replacement or repair of their aortic valve are not excluded.) * currently has a known clinically significant electrolyte imbalance or clinically significant arrhythmias which compromise subject's hemodynamic state. * patient has severe anemia (hemoglobin \< 8.0 g/dl) at screening * has received contrast within 10 days of procedure or has a planned additional cardiac or renal or other major surgical procedure within the 7 day follow-up period. * has ruled in for a serious heart attack within 48 hours of the planned procedure * has documented respiratory insufficiency as evidenced by an oxygen saturation of \< 90% on room air assessed on day of procedure. * planned addition, discontinuation or dose adjustment of nephrotoxic drugs * subject has a known hypersensitivity to furosemide and/or the contrast agent being used. * subject is currently, plans, or has been enrolled in another clinical study involving use of an investigational drug or device within the prior 30 days. * subject is pregnant or breastfeeding. * subject is unable to provide informed consent.
methorivac - vaccinal pharmacoepidemiologic

Conditions: Infants Likely to Present Febrile Convulsions

Summary: this project is the pilot step necessary to develop a system of vaccination pharmacoepidemiology that associates a sophisticated analytical approach, appropriate for this challenge and case series analysis, with the use of linked medicoadministrative data for hospitalisations the reimbursement of healthcare costs. this linkage of medicoadministrative data is new in france. the example of the risk of hospitalisation for febrile convulsions in infants less than two years old following vaccination against diphtheria, tetanus and pertussis is given as the reference association. this choice is justified by the numerous publications over many years on the existence of this association (miller et al bmj 1981, farrington et al lancet 1995). in addition, as case series analyses have been carried out to assess this risk, the results can be compared directly (lancet 1995). the study to determine whether the analysis tools are suitable for the data will be tackled at the following levels: * validity of the selection of cases from administrative records alone using coding based on the international classification of diseases icd10 * validity of the risk assessment. this methodology feasibility project must make it possible to identify the different potential problems. this is a prerequisite necessary for the systematic implementation.


Eligibility criteria:
inclusion criteria: - for reimbursement data: all of the data concerning delivery (purchase of the vaccine at a pharmacy, prescription) and vaccination (consultation following the date of purchase) for infants younger than 2 years old, in the years 2007 and 2008. - for pmsi data: all of the hospitalisations in 2007 and 2008 for febrile convulsions in infants less than 3 years old in hospitals of the following departments: côte d'or, doubs and bas-rhin exclusion criteria: -
assessing the occupation burden in copd

Conditions: Lung Diseases, Obstructive; Chronic Obstructive Pulmonary Disease

Summary: to assess the population burden of occupational exposures in the prevalence and progression of chronic obstructive pulmonary disease (copd).

background: chronic obstructive pulmonary disease is the only one of the top four or five leading causes of death in the u.s. with worsening epidemiological trends. cigarette smoking accounts for approximately 85 percent-90 percent of cases, but the other 10 percent-15 percent of the attributable risk still represents a substantial fraction of this disease that remains unexplained. recently, several studies, in various countries, have addressed whether certain occupational exposures (primarily those relating to dusts, vapors, gases, and/or fumes) are potential risk factors for copd. most of these studies have shown elevated odds ratios or relative risks, although not always to a statistically significant level. design narrative: a population sample of the continental united states of those aged 55-75, supplemented by an enriched sample in geographic "hot spots" identified by the national institute for occupational safety and health (niosh) through respiratory diseases mapping. structured telephone interviews assessed demographics, health status, smoking exposures, and occupational histories. high risk jobs were coded using a job matrix system independent of subject report of specific exposures. two hundred thirty-four of those with copd, with over-sampling of those with greater severity, were followed at 12-14 months to assess health status and health services utilization, as well as decrements in quality of life. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria
comparison of microwave ablation with cryoablation for breast tumor

Conditions: Breast Tumor; Microwave Ablation; Cryoablation

Summary: the investigators will perform this study to prospectively compare the clinical outcome after percutaneous microwave ablation(mwa) and cryoablation of benign and malignant breast lesion under ultrasound (us) guidance.

a total of more than 200 patients diagnosed with benign breast lesions and 50 patients with malignant breast lesions in two centers of china will be recruited in this study and underwent us-guided percutaneous mwa and cryoablation treatment. information for each patient includes demographics; longest diameters of tumors; tumor numbers; tumor pathological type; location of tumor according to whether adjacent to skin, pectoralis, areola and papilla. ablation variables including session, puncture, time, and power; complete ablation, complications; reduction in volume, palpability, pain and cosmetic satisfying outcomes,recurrence,survival will be compared and analyzed.

Eligibility criteria:
inclusion criteria: * (a) the breast tumor obtained the pathological diagnosis by using core-needle biopsy; (b) for the benign lesion, continually increasing during a half year followup,with the symptoms of local pain, discomfortable or compression considered probably relating to the mass of breast; the patient with evidently psychological pressure due to the occurrence of the bbl despite clearly benignancy on imaging; (c) for the malignant lesion, with the tumor size smaller than 2cm and without other metastasis. exclusion criteria: * (a) the patients who were pregnant or breast-feeding; (b) the patients with evidence of coagulopathy or acute or severe pulmonary insufficiency or heart dysfunction; (c) the patients during menstrual period; (d) the patients referring to other therapies including surgical excision and vacuum-assisted biopsy.
web based cardiac rehabilitation support in coronary artery patients

Conditions: Cardiac Rehabilitation; Healthy Lifestyle; Medication Adherence; Quality of Life; Coronary Artery Disease

Summary: this study was carried out as a randomized controlled experimental study to evaluate the effect of web-based cardiac rehabilitation support on the healthy lifestyle behaviors, medication adherence and quality of life in coronary heart patients.

hypothesis 1: h0: web-based cardiac rehabilitation support has no effect on increasing the healthy lifestyle behaviors of patients with coronary artery disease. h1: web-based cardiac rehabilitation support has an effect on increasing the healthy lifestyle behaviors of patients with coronary artery disease. hypothesis 2: h0: web-based cardiac rehabilitation support in patients with coronary artery disease has no effect on increasing the compliance of patients to drug therapy. h1: web-based cardiac rehabilitation support in patients with coronary artery disease has an effect on increasing the compliance of patients to drug therapy. hypothesis 3: h0: web-based cardiac rehabilitation support has no effect on improving the quality of life of patients with coronary artery disease. h1: web-based cardiac rehabilitation support has an effect on improving the quality of life of patients with coronary artery disease.

Eligibility criteria:
inclusion criteria: * patients with a diagnosis of coronary artery disease, adult patients, those for whom no surgical operation was planned, those who were clinically stable, those who were literate, those who could communicate verbally, use the internet, those who had a computer, tablet or smartphone, and those who agreed to participate in the study. exclusion criteria: * those who have a disease that is not suitable for the cr program, those who did not agree to participate in the study, those who did not log in after registering on the website, did not read the trainings and could not communicate with the patient during the study
vestibular evoked myogenic potentials in benign paroxysmal positional vertigo (vemp in bppv)

Conditions: Vertigo

Summary: benign paroxysmal positional vertigo (bppv) is the most frequent cause of vertigo of peripheral vestibular origin with life time incidence of 2.4%. bppv is characterized by bouts of acute whirling vertigo lasting less than one minute provoked by changes in head position in relation to the gravitational vector. the vertigo is accompanied by typical rotational or horizontal nystagmus that is often demonstrated by the dix-hallpike maneuver and less frequently by testing for positional nystagmus. bppv pathogenesis is currently explained by the fall of otoconia (calcium-carbonate crystals) or otoconial debris from the tectorial membrane of the otolithic organs into the dependant semicircular canals (canalithiasis) or adherence of such particles to the semicircular canal's cupula (cupulithiasis). under these circumstances, the semicircular canal which normally responds only to angular velocity and acceleration is stimulated by gravity. otoconial remnants as free floating particles inside the semicircular canal arms or attached to the cupula have been observed by few investigators. although the presence of such particles explains most characteristics of the positioning nystagmus described in bppv, it does not account for the dizziness and disequilibrium which are described by many patients even without changes in head position and the continuation of such symptoms after successful treatment of bppv as evidenced by the resolution of positional vertigo and nystagmus. the study hypothesis is that otolithic pathology is an important component in the pathogenesis of bppv explaining these symptoms, bppv recurrence, and the refractoriness of some bppv cases to the vastly employed particles repositioning treatments. in the present study the vestibular evoked myogenic potentials (vemp) testing would be employed to measure the function of one of the otolithic organs - the saccule. the study objectives are: 1. to investigate possible malfunction of the saccule in patients suffering from bppv. 2. to look for association between saccular pathology and bppv recurrence and between such pathology and bppv treatment failure. 3. to study possible relation between saccular pathology and continuation of dizziness and disequilibrium despite the resolution of positional vertigo.


Eligibility criteria:
inclusion criteria: * age 18-60 years * complaints of positional or positioning vertigo. * presence of typical nystagmus for posterior canal bppv in dix hallpike maneuver exclusion criteria: * patient younger than 18 or older than 60 years of age. * otoneurology bed-side examination reveals bilateral bppv. * audiometry and tympanometry show conductive hearing loss. * signs of retrocochlear lesion or central vestibular pathology in bed-side otoneurological examination or audiometry or eng/vng.

Keywords: benign paroxysmal positional vertigo vestibular evoked myogenic potentials sacculo-colic reflex
efficacy of tranexamic acid in preventing post operative blood loss in bone sarcoma patient

Conditions: Blood Loss, Surgical

Summary: investigator will see the efficacy of tranexamic acid in limb salvage surgery patients which will prevent blood loss and help in conservation of blood products.


Eligibility criteria:
inclusion criteria: * limb sarcoma of upper and lower limb * limb salvage exclusion criteria: * liver insufficiency * renal insufficiency * allergic to drug * history of thromboembolic condition * pregnancy * metastatic disease
efficacy of acupuncture and bee venom acupuncture on patients with idiopathic parkinson's disease

Conditions: Idiopathic Parkinson's Disease

Summary: the aim of this study is to evaluate the efficacy of acupuncture and bee venom acupuncture (bva) for idiopathic parkinson's disease (ipd) through a sham-controlled trial and investigate whether there is sustainability of treatments effects by follow-up assessments after the end of the treatment.

a total of 90 patients with idiopathic parkinson's disease (ipd) who have been on a stable dose of anti-parkinsonian medication for at least one month with two or more symptoms among tremor, rigidity, postural instability, and bradykinesia will be included in this study. participants will be randomly assigned to the study, the control, or the waiting group (2:2:1). initial assessment will be performed with the unified parkinson's disease rating scale (updrs) parts ii and iii, the parkinson's disease quality of life questionnaire (pdql), the beck depression inventory (bdi), and evaluation of the 20-m walking time and the steps to walk 20-m, as well as postural instability. acupuncture and bva treatments will then be performed on the study group, and sham acupuncture and normal saline injections will be performed on the control group twice a week for 12 weeks. the waiting group does not receive any added treatment during the 12 weeks. the initial assessment will be repeated after 12 weeks in all groups. in the study and the control groups, an additional assessment will be repeated after 16 and 20 weeks.

Eligibility criteria:
inclusion criteria: * patients with ipd who have been on a stable dose of anti-parkinsonian medication for at least one month. * hoehn \& yahr scale i-iv * more than one point in two or more items (tremor, rigidity, postural instability, and bradykinesia) in the updrs part iii, etc. exclusion criteria: * severe psychiatric or organic brain disorders other than pd, previous or current * secondary parkinsonism due to cerebrovascular disease, tumor, infection, etc. * atypical parkinsonian or parkinson plus syndrome

Keywords: parkinson's disease idiopathic parkinson's disease acupuncture bee venom acupuncture