Kornimate/medical-research-clean huggingface dataset:
safety and effectiveness of ihat in iron deficient pre-menopausal woman

Conditions: Iron-deficiency

Summary: this is a double blind, randomised, placebo-controlled trial to evaluate orally-dosed ihat (iron hydroxide adipate tartrate) at 2 different doses compared to placebo for increasing serum ferritin levels in iron-deficient but otherwise healthy premenopausal women over 12 weeks.


Eligibility criteria:
inclusion criteria: * generally healthy iron deficient pre-menopausal women * iron deficiency defined as serum ferritin \< 30 ug/l (1) * generally healthy defined as c-reactive protein \< 3 mg/l (1) * subjects adhering to a vegetarian or vegan diet are allowed * agree not to give blood donations during the study * able to provide informed consent * agree not to participate in another clinical trial while enrolled in this trial * agree not to change current diet and/or exercise frequency or intensity exclusion criteria: * anaemia (as determined from the haematocrit and haemoglobin measures) (2) * previously told they have an iron absorption problem * subjects regularly taking iron specific supplements during or 2 months prior to study commencement (the use of other mineral/vitamin/herbal preparations is allowed but should be recorded) (3) * any uncontrolled serious illness (4) * receiving/prescribed coumadin (warfarin), heparin, dalteparin, enoxaparin or other anticoagulation therapy * active smokers, nicotine use, alcohol(5) or drug (prescription or illegal substances) abuse * chronic gastrointestinal disorders * pregnant/lactating women or women trying to conceive * diagnosed depression or mental disorder that is uncontrolled * eating disorders * bmi \> 35 kg/m2 * allergic to any of the ingredients in active or placebo formula * any condition which in the opinion of the investigator makes the participant unsuitable for inclusion * participants who have participated in any other clinical trial during the past 1 month footnotes 1. a blood test is required prior to enrolment into the study to receive trial product. participants will be required to attend a local pathology collection centre and have serum ferritin and crp within the required limits to be considered enrolled in the study and be provided with trial product. 2. anyone considered to be anaemic will be excluded and directed to their gp. in women, anaemia is defined as any of the following: haemoglobin \< 115 g/l, haematocrit \< 35%. 3. potential participants that are taking supplements that would result in their exclusion must wait an 8-week washout period prior to commencing the study. 4. an uncontrolled illness is any illness that is currently not being treated with a stable dose of medication or is fluctuating in severity. a serious illness is a condition that carries a risk of mortality, negatively impacts quality of life and daily function and/or is burdensome in symptoms and/or treatments. 5. chronic past and/or current alcohol use (\>14 alcohol drinks/week).
x-ray dose reduction study for endovascular interventional radiology

Conditions: Cardiovascular Disease

Summary: clarityiq is a novel x-ray imaging technology, that combines advanced real-time image noise reduction algorithms, with state-of-the-art hardware to reduce patient entrance dose significantly. this is realized by anatomy-specific optimization of the full acquisition chain (grid switch, beam filtering, pulse width, spot size, detector and image processing engine) for every clinical task individually. furthermore, smaller focal spot sizes, shorter pulses and the introduction of automatic real-time motion compensation in subtraction imaging are used, which are known to positively influence image quality . the final effect on the clinical image quality in peripheral angiography is investigated in this study.

x-ray dose and image quality are related by laws of physics. low dose and high image quality cannot be achieved at the same time. however, image processing algorithms can help an x-ray system to acquire images with lower dose without influencing image quality or achieving higher image quality with equal dose. the primary aim of this study is to verify if the diagnostic image quality is equal or better when using a significant reduction in x-ray dose for endovascular digital subtraction angiography in combination with a novel imaging technology compared to using normal dose with conventional image technology.

Eligibility criteria:
inclusion criteria: * patients older than 18 years of age undergoing digital subtraction angiography for diagnosis or treatment of iliac artery disease. exclusion criteria: * patients not willing or unable to give consent to participate * patients already involved in a clinical trial * patients under the age of 18 * pregnant or breastfeeding women * patients with kidney disease (egfr \< 60)

Keywords: x-rays endovascular angiography image processing
feasibility study: conservative treatment in cervical cancer

Conditions: Stage IB1 Cervical Cancer

Summary: currently conservative treatment for patients of childbearing affected by cervical cancer is reserved for women with figo stage ia2 - ib1 with tumor size less than 2 cm . the trachelectomy and the cone biopsy with pelvic lymphadenectomy are the choice for these patients wishing to preserve their reproductive function. in this context , recently literature show the results about the use of neo-adjuvant chemotherapy about the reduction of tumor volume and therefore the magnitude of the subsequent surgical treatment (including patients with tumors larger than 2 cm ). so it becomes crucial a prospective analysis on the possibility to include in this type of treatment patients with stage ib1 and iia1 with tumor size greater than 2 cm ( up to 4 cm ) . the current study , in fact , would like to do a prospective evaluation on the advantages of neo-adjuvant chemotherapy in the possibility of broadening the inclusion criteria to conservative treatment in women , suffering from cervical cancer, stage ib1 and iia1 ( with tumor volume between 2 and 4 cm) and wishing to preserve their reproductive function.

the investigators would like to be conservative in young patients affected by early stage cervical cancer.

Eligibility criteria:
inclusion criteria: * squamous cervical cancer or adenocarcinoma in figo stage ib1-iia, tumor volume between \> 2 and ≤ 4 cm (instrumental evaluation). * informed consensus * childbearing * fertility (through us and ormonal withdrawal pre - e post neoadjuvant chemotherapy * asa (american society of anesthesiologist) class \< 2 exclusion criteria: * ongoing pregnancy

Keywords: cervical cancer neoadjuvant chemotherapy adverse effects
clinical study of intratumoral injection of car-t cells in the treatment of advanced liver tumors

Conditions: Hepatocellular Carcinoma , Cholangiocarcinoma

Summary: objective to study the safety and preliminary efficacy of intratumoral injection of car-t cells in the treatment of advanced liver tumors.


Eligibility criteria:
inclusion criteria: * gpc3 expression was positive by histological examination; * 18-69 years old; * the patients with advanced liver tumor who can not be operated and the effect of chemotherapy is poor; * the patients who received traditional palliative therapy had an expected survival period of more than 4 months; * organ status allows clinical application.a. creatinine \ 55%; c. heme \> 9g / dl, bilirubin \< 2.0mg/dl; * no bleeding and coagulation disorders were found; * there was no allergy to contrast medium; * contraception: contraceptive measures were taken during clinical application and within 3 months after the last cells transfusion; * there is no other contraindication for lymphocyte collection; * sign informed consent. exclusion criteria: * pregnant or lactating women; * patients need systemic steroids therapy; * at present, the treatment conditions are as follows : a. within 30 days before the collection of peripheral blood mononuclear cells,patiens were in other anti-tumor clinical observation period; b. patients have not recovered from the acute side effects of previous treatment; * patients received radiotherapy within 4 weeks after enrollment; * patients received other cell modification therapy in the early stage; * in the screening stage, patients with lymphocyte transfection rate less than 5%, or t cell culture can not expand (\< 5 times) patients; * uncontrolled symptoms or other diseases include, but are not limited to, infection, congestive heart failure, unstable angina pectoris, arrhythmia, psychosis, or limiting the social environment that meets the requirements, or the researchers believe that they may bring unpredictable risks; * patients with severe acute allergic reactions; * patients who participated in other clinical trials; * researchers believe that patients are not suitable to participate.
efficacy and safety of chemotherapy combined with car-t cells in newly diagnosed adult patients with ph- b-all

Conditions: Philadelphia Chromosome Negative ALL; Acute Lymphoblastic Leukemia, Adult

Summary: in recent years, immunotherapy (eg. blinatumomab, inotuzumab ozogamicin, car-t cells) has demonstrated a high safety and efficacy profile in relapsed/refractory (r/r）b-all. the available data suggest that the advancement of immunotherapy from relapsed/refractory (r/r) field to the frontline setting may be an important approach to increase the depth of remission, which ultimately translates into a survival benefit. in this study, the investigators propose a treatment regimen using car-t cell therapy as a consolidation method for ph- b-all patients achieving complete remission (cr) with chemotherapy, aiming to reduce the total cycles of chemotherapy and related toxicities, shorten length of hospitalization, and ultimately improve patients' survival and quality of life.

the car-t cells were murine-derived second-generation cd19 car-t with a co-stimulation domain of 4-1bb, and the infusion dose was 1×10\^6/kg car+ cells in a single infusion.

Eligibility criteria:
inclusion criteria: 1. de novo and primary ph/bcr-abl1 negative acute lymphoblastic leukemia diagnosed by the bone marrow cytomorphology, immunophenotyping, cytogenetics and molecular biology according to who classification 2. male or female patients aged 18 years or older 3. cd19 expression on blasts 4. expected survival time greater than 3 months 5. adequate end organ function as defined by: total bilirubin ≤ 1.5 x upper limit of normal（uln）; serum alanine aminotransferase (alt) and serum aspartate aminotransferase (ast) ≤ 2.5 x uln or ≤5 x uln if leukemic involvement of the liver is present; creatinine ≤ 1.5 x uln; serum amylase and lipase ≤ 1.5 x uln; alkaline phosphatase ≤ 2.5 x uln unless considered tumor related; normal electrolytes: potassium ≥ lln; magnesium ≥ lln; phosphorus ≥ lln; cardiac color doppler ultrasound ejection fraction ≥ 45% 6. subject has provided written informed consent prior to any screening procedure exclusion criteria: 1. burkitt lymphoma/leukemia 2. acute leukemia of ambiguous lineage 3. clinical manifestations of active cns or extramedullary involvement with all 4. female patients who are pregnant or breast feeding 5. uncontrolled active serious infections that could, in the investigator's opinion, potentially interfere with the completion of treatment 6. known hiv seropositivity 7. clinically significant ventricular arrhythmias, unexplained syncope (not vasovagal) or sinus block, history of chronic bradycardia with a high degree of atrioventricular (av) conduction block (unless a permanent pacemaker is implanted) 8. any serious psychiatric illness that could, in the investigator's opinion, potentially interfere with the completion of treatment 9. other conditions assessed by the investigators to be inappropriate for this study

Keywords: philadelphia chromosome negative precursor b-cell acute lymphoblastic leukaemia car-t cell venetoclax newly diagnosed
chocking first aid management program for health care support workers.

Conditions: Choking

Summary: to determine the effect of chocking first aid awareness program on knowledge, attitude and practice of health care support workers. despite the importance of first aid skills, there may be gaps in the knowledge of healthcare support workers regarding choking management. a well-designed program can address these gaps, ensuring that workers are aware of the latest guidelines and techniques for managing choking incidents. knowledge and attitudes alone are not sufficient; practical skills are crucial. the program aims to translate theoretical knowledge and positive attitudes into effective practice. training can enhance the workers\&#39; ability to perform first aid procedures correctly and confidently.

it is very important for every person in the community to know about first aid training to save lives and improve the overall quality of community health. health care professionals and trainees are expected to know about it, as they frequently face life threatening situations in their daily practice.

Eligibility criteria:
inclusion criteria: * physical therapist * pharmacists * lab technicians * minimum 1 year of practice exclusion criteria: * unwilling * any upper-limb msk problem * recent certification on emergency management

Keywords: knowledge attitude practice chocking first aid
effect of smoking on the expression of gelatinases in chronic periodontitis

Conditions: Periodontitis; Smoking

Summary: this study comparatively evaluate the expressions of mmp-2 and mmp-9 in smoker vs non-smoker chronic periodontitis patients as well as periodontally healthy subjects. the hypothesis of this study was that smoking may interfere with periodontal disease by effecting mmp-2 and mmp-9 expressions.

smokers have greater risk for developing periodontal disease and smoking is highly correlated with greater marginal bone loss. matrix metalloproteinases (mmp) play a major role in periodontal tissue destruction. mmp-2 and mmp-9, called gelatinases, are one of the major mmps that plays important roles in periodontitis. to date, several studies showed the increased levels of gelatinases in periodontal disease and only a limited number of study investigated the effect of smoking on gelatinases. however, no previous study has directly investigated the possible relationship between smoking and gingival tissue gelatinases expressions (mmp-2 and mmp-9) in chronic periodontitis (cp) patients relative to periodontally healthy subjects. therefore this study is conducted to comparatively evaluate the expressions of mmp-2 and mmp-9 in smoker vs non-smoker chronic periodontitis patients as well as periodontally healthy subjects. the of this study hypothesis was that smoking may interfere with periodontal disease by effecting mmp-2 and mmp-9 expressions.

Eligibility criteria:
inclusion criteria: * a total of 80 subjects (35 females, 45 males, with an age range of 16-62 years) were included in this study from those patients seeking dental treatment at the baskent university school of dentistry between february 2010 and december 2012. exclusion criteria: * patients with systemic disease; * pregnant and/or lactating women; * patients taking any medications that may influence the study.

Keywords: chronic periodontitis smoking mmp-2 mmp-9
dexmedetomidine, magnesium sulphate and lidocaine for cough suppression after general anesthesia

Conditions: Cough

Summary: the aim of this prospective randomized controlled double-blinded study is to compare the efficacy of dexmedetomidine, mgso4 and lidocaine for cough suppression during general anesthetic emergence as regard number and severity.


Eligibility criteria:
inclusion criteria: * aged 21-60 years. * both genders. * body mass index \< 30 kg/ m2 * american society of anesthesiology (asa) physical status i-ii. * mallampati score class i or ii. * patients undergoing surgery under general anesthesia. exclusion criteria: * known allergy to study drugs. * history of psychiatric illness. * patients with major organ diseases. * pre-existing neurological deficits. * body mass index \>30 kg/m2. * active airway infection or history of tracheal and laryngeal surgery. * lower esophageal sphincter incompetence (and reflux). * increased intracranial and intraocular pressure. * use of cough-inducing medications * pregnant, and lactating women.
the effect of self-acupressure application on pain, fatigue and sleep quality in cancer patients receiving chemotherapy

Conditions: Cancer

Summary: the aim of this study is to examine the effect of self-acupressure application on pain, fatigue and sleep quality in cancer patients receiving chemotherapy.

self-acupressur application will improve pain, fatigue and sleep quality in cancer patients receiving chemotherapy.

Eligibility criteria:
inclusion criteria: * to have received at least one course of adjuvant chemotherapy before, * not having a psychiatric diagnosis, * being an early stage cancer patient * to be able to communicate adequately * not having psychiatric problems * volunteering to participate in research exclusion criteria: * none

Keywords: self-acupressur cancer patients pain fatigue sleep quality
endometrial injury and ivf-et outcome

Conditions: Infertility

Summary: implantation of the human embryo is the limiting factor in the success of invitro-fertilization and embryo transfer(ivf-et).we wanted to find out whether creating a local injury to the endometrium in the non-transfer cycle would improve the ivf-et outcome in the subsequent cycle.we believe that the injury created causes release of substances which help in implantation.

study design and subjects: this is a randomized control study designed to evaluate the effect of local injury to the endometrium in non-transfer cycle in patients with previous failed ivf. patients will be randomly allotted to control and intervention group the patients in the intervention group pipelle endometrial sampling 7-10th day and 24-26th day in the cycle prior to ivf transfer cycle. outcome measures: clinical pregnancy rate,implantation rate and ongoing pregnancy rate. sample size: 100 patients (50 in each group).

Eligibility criteria:
inclusion criteria: * previous failed in-vitro fertilization embryo transfer cycle * patients who are good responders and have good quality embryos in the previous attempts * age of patients upto 37yrs exclusion criteria: * those detected to have endometrial tuberculosis in the past, including those treated with antituberculosis treatment * those with intramural fibroid distorting the endometrial cavity/sub-mucous myoma * those with sonographically detected hydrosalpinx

Keywords: invitro-fertilization ,embryo transfer,endometrial injury
perfusion index in anesthesia

Conditions: Monitoring, Physiological

Summary: in patients under general anesthesia the investigators wish to investigate association and covariance between a peripheral perfusion index as obtained by radical 7 monitor (masimo, irvine, ca, usa) and more traditional hemodynamic parameters, ie. invasive blood pressure and sv as obtained by lidco rapid monitor (lidco ldt., london, uk)


Eligibility criteria:
inclusion criteria: * patients for elective and sub-acute surgical repair of para-oesophagal hernia. * willingness to participate exclusion criteria: * patient refusal

Keywords: perfusion index hemodynamics anesthesia stroke volume
cardiovascular variability, heart rate response, and electromyogram power associated with periodic leg movements.

Conditions: Restless Legs Syndrome

Summary: periodic leg movements during sleep is associated with microarousals and a stimulation of the sympathetic nervous system. the knowledge of this autonomic activation may help understanding the increase of cardiac risk observed in elderly. the aim of the study is to evaluate the relationship between periodic leg movements severity, age, gender, electromyographic power and heart rate response associated with periodic leg movements. drug-free patients diagnosed with periodic leg movements were included. clinical data and 24-h polysomnography recordings were analyzed.


Eligibility criteria:
inclusion criteria: * restless legs syndrome patients * hospital routine for periodic leg movements diagnosis * plms index \> 0 exclusion criteria: * narcolepsy-cataplexy * sleep irregularities and sleep deprivation symptoms * lack of neurological or psychiatric diseases * upper airway resistance syndrome * obstructive sleep apnea * treatment, cerebral lesion, medical illness * medication or drinks affecting sleep and wake state

Keywords: restless legs syndrome periodic leg movements heart rate heart rate variability microarousals autonomic nervous system activity
peraf: af termination vs prespecified ablation

Conditions: Persistent Atrial Fibrillation

Summary: the design of this study is an intervention, randomized, controlled study and contains two randomized groups：（1）af-termination group；（2）prespecified-ablation group.


Eligibility criteria:
inclusion criteria: 1. aged between 18 and 80 years old; 2. patients undergoing a first-time ablation procedure for persaf, and in spontaneous af at the beginning of the procedure; 3. diagnosed as persistent af according to the latest clinical guidelines，with atrial fibrillation lasting for at least one month; 4. ineffective or intolerable to ≥1 anti-arrhythmia drug treatment; 5. patients must be able and willing to provide written informed consent to participate in this study; 6. patients must be willing and able to comply with all study follow- up requirements. exclusion criteria: 1. .uncontrolled congestive heart failure, ef \<35%; 2. . history of severe valve disease and/or prosthetic valve replacement; 3. . myocardial infarction or stroke within 6 months; 4. . severe congenital heart disease; 5. . left atrial diameter ≥60mm; 6. . contrast agent allergy; 7. . the use of anticoagulant drugs is contraindicated; 8. . severe lung disease; 9. . left atrial thrombus confirmed by preoperative esophageal ultrasound; 10. .contraindications for cardiac catheterization; 11. .prior left atrial ablation (surgical or catheter); 12. .have performed any cardiac surgery within 2 months; 13. .poor general health; 14. .life expectancy \< 12 months, including factors such as physical inability to tolerate ablation or unstable disease conditions.-
metacognitive intervention for individuals with severe mental disorders

Conditions: Schizophrenia

Summary: the overall aim of this study was to develop a meta-cognitive group intervention in order to apply it and to understand and distinguish the components that influence participation among people with schizophrenia

the overall aim of this study was to develop a meta cognitive group intervention in order to apply it and to understand and distinguish the components that influence participation among people with schizophrenia. the specific objectives were to: 1. improve participation by increasing the effectiveness of cognitive strategy use and teaching clients to independently review performance and to examine the strategy's effectiveness. 2. compare the use of cognitive strategies between participants with schizophrenia and their matched controls following the meta cognitive group intervention and to correlate the cognitive strategies use and participation following the meta cognitive group. 3. examine whether symptoms moderate the association between metacognitive outcomes and participation among people with schizophrenia following the meta cognitive group.

Eligibility criteria:
inclusion criteria: * confirmed diagnosis of schizophrenia by a licensed psychiatrist * fluency in hebrew * t-score of at least 65 on the behavior rating inventory of executive function-adult version exclusion criteria: * severe psychiatric hospitalization of over 24 hours during the month prior to the beginning of the study * used drugs or alcohol

Keywords: executive function meta-cognition schizophrenia meta-cognitive intervention