Kornimate/medical-research-clean huggingface dataset:
surgery plus intraoperative peritoneal hyperthermic chemotherapy (iphc) to treat peritoneal carcinomatosis

Conditions: Stomach Neoplasms; Colorectal Neoplasms; Neoplasm Metastasis; Mesothelioma

Summary: objectives: * determine response and survival of patients with peritoneal carcinomatosis treated with cytoreductive surgery plus intraoperative peritoneal hyperthermic chemotherapy with cisplatin and mitomycin * assess the quality of life of patients treated with this regimen. outline: patients are randomized into iphc group and control group. in the former group, the patients undergo cytoreductive surgery plus intraoperative hyperthermic peritoneal perfusion with cisplatin and mitomycin over 60 minutes. patients in the control group just underwent routine cytoreductive surgery. all patients in both groups receive the standard conventional chemotherapy after surgery. quality of life is assessed at study initiation, at 1, 3, 6 months. patients are followed at 4 weeks, every 3 months for 1 year, and then every 6 months for up to 3 years.

disease characteristics: * histologically confirmed peritoneal carcinomatosis with the following histologies: * primary peritoneal mesothelioma * adenocarcinoma of gastrointestinal tract origin * confined to peritoneal cavity * tumor mass could be debulked to less than 2.5 cm in diameter per tumor deposit * must not have failed prior intraperitoneal platinum therapy * treatment failure is defined as radiographic evidence of disease progression on 2 consecutive ct scans within 3 months after therapy patient characteristics: age: - 20 to 70 years old performance status: - kps\>50 life expectancy: - more than 8 weeks hematopoietic: * wbc at least 3,500/mm\^3 * platelet count at least 80,000/mm\^3 hepatic: * bilirubin no greater than 2 times upper limit of normal (uln) * ast and alt no greater than 2 times uln * liver enzymes no greater than 2 times uln renal: - creatinine no greater than 1.5 mg/dl cardiovascular: * no significant irreversible cardiac ischemia * no significant changes in ecg recording pulmonary: * fev_1 at least 1.2 liters * maximum voluntary ventilation at least 50% expected other: * not pregnant or nursing * negative pregnancy test * no concurrent medical problems that would preclude surgery

Eligibility criteria:
inclusion criteria: * gastric cancer or colorectal cancer with peritoneal carcinomatosis * gastric cancer or colorectal cancer with malignant ascites * karnofsky performance scale(kps)\>50 exclusion criteria: * age less than 20 years old, or beyond 70 years old * any lung metastasis, liver metastasis, or prominent retroperitoneal lymph node metastasis * bilirubin greater than 3 times upper limit of normal (uln) * ast and alt greater than 5 times uln * liver enzymes greater than 3 times uln

Keywords: peritoneal carcinomatosis cisplatin mitomycin gastric cancer colorectal cancer
registry to assess long-term outcome in hiv subjects who participated in phase 2 and 3 clinical trials involving vicriviroc (study p04999)

Conditions: HIV Infections

Summary: nonrandomized, prospective, observational, multi-site registry to assess long-term safety, clinical outcome, deaths, and evolution of viral tropism in hiv subjects who completed or discontinued participation in phase 2 or 3 clinical trials involving vicriviroc. subjects will be followed for up to 5 years.

a non-probability sampling method will be used. subjects will be requested to enroll in the registry after having completed or discontinued participation in a phase 2 or 3 study involving vicriviroc.

Eligibility criteria:
inclusion criteria: * subjects must have participated in a phase 2 or 3 study involving vicriviroc, and must have received, but are no longer receiving study medication. exclusion criteria: * unwillingness to participate in the registry or give informed consent.

Keywords: treatment experienced
use of neuromuscular blocking agents and neuromuscular monitoring in 7 danish teaching hospitals

Conditions: Neuromuscular Blockade

Summary: aim: to explore * the frequency of use of objective neuromuscular monitoring for assessment of depth of neuromuscular blockade in general anaesthesia * the incidence of residual neuromuscular blockade, and * the timing of reversal of the neuromuscular blockade at the end of anaesthesia. we will collect data from 7 danish anaesthesia departments, using data from the anaesthesia information management system (aims).


Eligibility criteria:
inclusion criteria: patients who received general anaesthesia with neuromuscular blockade in one of the 7 hospitals providing data for the study in the last 18 months up until the time of data collection

Keywords: residual nerve blockade neuromuscular monitoring residual curarization neuromuscular blocking agents
tfl vs moses holmium laser in the en-bloc resection of bladder tumors

Conditions: Urolithiasis of Bladder

Summary: the goal of this randomized clinical trial is to determine if there is difference in pathological and clinical outcomes between moses and tfl in the transurethral laser enucleation of bladder tumors. the main question it aims to answer is: is there a difference in pathological and clinical outcomes between moses holmium and thulium fiber laser (tfl) in the transurethral laser enucleation of bladder tumors? participants will randomized to either tfl of moses arm for their bladder resection procedure.

an estimated 12,500 canadians are diagnosed with bladder cancer each year. diagnosis and treatment involve transurethral (through the urethra) resection of tumor or tissue called the turbt procedure. this procedure yields excellent results and minimal morbidity and mortality but has a high recurrence rate, difficulties in the pathologic interpretation of the specimen (due to cautery effect), and procedure-related complications (excessive bleeding, bladder perforation, bowel injury, and inadvertent extensive injury to urethra) that may delay treatments such as chemotherapy which would further impact oncologic outcomes. with the advancement of technology, new methods of transurethral tumor removal have emerged, such as the use of laser energy. using laser energy, the tumour is resected in one piece, whereas the turbt approach requires breaking the tumor into pieces. this allows for better pathology analysis that can determine treatment pathways for the patient, as well as reduces the risk of complications. the standard lasers used have been the moses holmium laser and the thulium fiber laser (tfl).

Eligibility criteria:
inclusion criteria: 1. over 18 years of age at the time of enrollment. 2. patients presented with visual criteria suggesting bladder tumor by outpatient cystoscopy will be legible for inclusion. exclusion criteria: 1. tumors deemed not eligible for laser resection as determined by the urologist e.g. obvious muscle-invasive or metastatic at presentation 2. synchronous either urethral tumors or upper urinary tract tumor 3. history of carcinoma in situ 4. contracted bladder
the effects of pulmonary hypertension web-based health care program on symptom management, social support, activity tolerance, and quality of life in patients with pulmonary hypertension.

Conditions: Web-based Health Care Program

Summary: pulmonary arterial hypertension (pah) is a chronic disease characterized by an elevation in pulmonary artery pressures and pulmonary vascular resistance. the condition most often is rarely detected, and patients frequently suffer symptoms for several years before being appropriately diagnosed. patients with ph suffer from several symptoms, such as exertional dyspnea, fatigue, weakness, chest pain, fainting...et al. pulmonary hypertension is an incurable and progressive disease with complex symptoms and treatments. patients must learn to deal with their unpredictable future and manage the complex treatments associated with severe adverse effects and need significant changes in lifestyle. therefore, it is important to assist patients to develop the ability of symptom management.


Eligibility criteria:
inclusion criteria: 1. at least 20 years old, diagnosed by clinical specialists as patients with pulmonary hypertension (group1 and group 4) 2. clear consciousness, able to communicate in mandarin and taiwanese, with normal hearing 3. those who have internet or mobile internet at home 4. adults without mental illness 5. no alcohol or drug abusers. exclusion criteria: 1. critical disease
lidocaine infusions for rib fractures

Conditions: Rib Fracture Multiple; Trauma Chest; Pain, Acute

Summary: patients with traumatic rib fractures not receiving regional anesthesia through a epidural or nerve block catheter will be recruited for the study. once enrolled, they will be randomized to receive either intravenous lidocaine or intravenous saline for control of pain related to their rib fractures. in addition, they will receive other pain medications, such as acetaminophen, gabapentin, and opioid pain medications. our primary outcome is a decrease in their opioid medication requirements.


Eligibility criteria:
inclusion criteria: patients aged 18 or older with 2+ rib fractures or \> 65 with 2+ rib fractures enrollment within 16 hours of admission inability to receive epidural placement or other catheter-based regional anesthesia (coagulopathy, anticoagulation, bacteremia or infection over epidural site, patient refusal, vertebral fracture, spinal cord injury, inability to cooperate with procedure, bmi \> 40) isolated rib fracture (no other major injury or anticipation for invasive procedure) exclusion criteria: inability to participate in traditional pain measures severe alcohol withdrawal chronic pain requiring opiates prior to admission gcs \< 13 or inability to report pain medical instability positive pressure ventilation, either via non-invasive mask or endotracheal tube hemodynamic instability or shock flail chest with clinical evidence of paradoxical rib motion contraindication to lidocaine history of or current bradycardia (hr \< 50) or heart block (mobitz ii or 3rd degree) new onset or uncontrolled seizures allergy to amide-type local anesthetic enrollment in other study that may affect the results of this study

Keywords: lidocaine infusion
knowledge, attitudes, and practices of operative vaginal birth among obstetric providers in egypt

Conditions: Birth Outcome, Adverse

Summary: the goal of this observational study is to evaluate the knowledge, attitudes, and practices of operative vaginal birth among obstetric providers in egypt. the main questions it aims to answer are: * what is the level of knowledge among obstetric providers regarding operative vaginal birth? * what are the attitudes and practices of obstetric providers towards operative vaginal birth? participants will: * complete a detailed questionnaire assessing their knowledge, attitudes, and practices related to operative vaginal birth. * provide demographic information to contextualize their responses.


Eligibility criteria:
inclusion criteria: * licensed obstetricians: only obstetricians who are currently licensed to practice in egypt. * active practice: obstetricians who are actively practicing in hospitals or clinics in egypt. * experience: obstetricians with a minimum of one year of experience in obstetrics and gynecology. * consent: willingness to participate and provide informed consent. * language: ability to understand and complete the questionnaire in english. exclusion criteria: * non-obstetricians: healthcare providers who are not obstetricians. * inactive practice: obstetricians who are not currently practicing in egypt. * insufficient experience: obstetricians with less than one year of experience in the field. * non-consent: individuals who do not provide informed consent to participate in the study. * language barrier: obstetricians who are unable to understand and complete the questionnaire in english.

Keywords: operative forceps vaginal birth birth injuries
nasal and pulmonary nitric oxide output in covid-19 infection

Conditions: COVID-19; SARS-CoV-2 Infection

Summary: a study of the relation of covid-19 infection and its severity to upper and lower airway nitric oxide, upper airway viral load and lung function.

materials and methods: prospective cohort of 40 covid-19, severe acute respiratory syndrome coronavirus 2 (sars-cov-2), positive patients from tampere university hospital region are recruited to the study. forty covid-19 negative patients with similar symptoms act as a control group. all subjects are screened for other respiratory viruses with reverse transcriptase polymerase chain reaction (rt-pcr)-multiplex tests. viral loads of sars-cov-2 from anterior nasal cavity, nasopharynx, throat and saliva are evaluated by rt-pcr cycle treshold (ct) value and antigen testing (rlu value). during the first visit news (national early warning score), recorded pulmonary auscultation (thinklabs one, thinklabs medical llc), impulse oscillometry (tremoflo, thorasys thoracic medical systems inc), feno (fractional exhaled nitric oxide) and fnno (fractional nasal nitric oxide) (niox vero®,circassia) are conducted. all aforementioned and a spirometry are measured again after 2 months. aims: to evaluate the relation of covid-19 infection and its severity to upper and lower airway nitric oxide, viral load and lung function. to compare the capability of rt-pcr in detecting sars-cov-2 rna from saliva, anterior nasal swab samples and oropharyngeal swap samples vs. the golden standard of nasopharyngeal swab samples. to compare the results of rt-pcr and antigen test in detecting sars-cov-2 from nasal and pharyngeal sample sites.

Eligibility criteria:
inclusion criteria: * capable of breathing through nose, no need of supplemental oxygen, symptom onset within 10 days, positive sars-cov-2 test in fimlab and capable of performing all required tests exclusion criteria: * need of supplemental oxygen, pregnancy, lactation, incapability of performing the tests for any reason, use of organic nitrate medication
the effect of 10-week exercise training on children with asthma

Conditions: Asthma in Children

Summary: the goal of this research is to determine whether 10-weeks of exercise training can benefit asthmatic children and young adults with a history of exercise-induced bronchoconstriction (eib). the investigators will also study an exciting newly discovered aspect of gene expression regulation in the white blood cells known as epigenetics: a process that takes place when genomic changes happen as a result of exposure to the environment. this study is based on emerging exciting new data from this and other laboratories demonstrating that (a) white blood cells play an important role in bronchoconstriction in children, (b) gene and cytokine expression in circulating white blood cells are abnormal in asthma and (c) brief exercise may change genomic and inflammatory- profiles of these cells.physical activity is an essential component of growth and health in children, thus, this research will lead to improved clinical uses of exercise as preventive and adjunctive therapy in the current epidemic of childhood asthma


Eligibility criteria:
inclusion criteria: * good health * physical activity * no evidence of disease or disability * diagnosed with persistent asthma (asthma subjects) * bmi\<95 percentile exclusion criteria: * use of illegal drugs or alcohol * very high physical fitness * pregnancy * more than two asthma attack per week (asthma subjects)
malondialdehyde and nitrous oxide as salivary biomarkers for different oral lesions

Conditions: Oral Lichen Planus; Oral Cancer; Leukoplakia; Oral Keratoses

Summary: investigating the level of malondialdehyde (mda) \& nitric oxide (no) in saliva in oral premalignant and malignant lesions in order to determine their diagnostic value for the malignant and potentially malignant lesions.

being a detrimental disease, cancer development is a very complicated process that requires many sequential steps and depends on a various number of genetic alterations and factors(1). among these factors are the free radicals which are derived either from endogenous or exogenous sources (5). free radicals result in an oxidative stress of the affected cells generating a body imbalance between oxidants and antioxidants (6). in this regard, saliva has been currently used to assess this possible oxidative imbalance through various salivary biomarkers including nitric oxide (no) and malondialdehyde (mda). saliva could be used as a very interesting rich medium, known for its role in diagnosis, prognosis and treatment that has become more prominent in oral diseases (6). nitric oxide (no) is an intercellular messenger molecule having many important biological functions. the levels of nitric oxide in salivary secretions could be used to monitor the severity of many underlying disease processes. moreover, malondialdehyde (mda) has been the most frequently used biomarker of oxidative stress in many pathological conditions such as cancer. it resulted from reactive oxygen species lipid degradation and induced toxic stress in affected cells, making both biomarkers a point of focus in monitoring clinical progress of suspected lesions

Eligibility criteria:
inclusion criteria: * healthy individuals with one of the following oral lesions : * keratosis * oral lichen planus * oral squamous cell carcinoma * oral leukoplakia exclusion criteria: * subjects having systemic disorders * pregnant or lactating females; * subjects who suffered from any other mucosal lesions; * severe periodontal inflammation.

Keywords: malondialdehyde nitric oxide salivary biomarkers
effect of maraviroc on endothelial function in hiv-infected patients

Conditions: HIV Infection; Cardiovascular Disease; Inflammation; HIV Infections

Summary: the purpose of this study is to determine the potentially beneficial aspects of ccr5 inhibition on inflammation and endothelial function as measured by brachial artery reactivity in antiretroviral treated hiv patients with an undetectable viral load.


Eligibility criteria:
inclusion criteria: 1. stable antiretroviral therapy for at least 12 months 2. all plasma hiv rna levels within the past year must be below level of detection (\ 50 but \< 200 copies will be allowed. 3. screening plasma hiv rna levels \< 50 copies rna/ml 4. \>90% adherence to therapy within the preceding 30 days, as determined by self-report 5. females of childbearing potential must have a negative serum pregnancy test at screening and agree to use a double-barrier method of contraception throughout the study period. exclusion criteria: 1. ongoing or prior use of any integrase inhibitor or r5 inhibitor. 2. patients who plan to modify existing antiretroviral therapy in the next 24 weeks for any reason 3. serious illness requiring hospitalization or parental antibiotics within preceding 3 months 4. concurrent or recent exposure to any immunomodulatory drugs 5. advanced liver disease or active hepatitis b or c 6. patients with systolic blood pressure \<100/70 7. starting or stopping statin therapy during the trial

Keywords: treatment experienced ccr5 receptor maraviroc
resuscitation fluid choice and clinical outcomes

Conditions: Large Volume Resuscitation; Acute Kidney Injury; Hyperchloremic Metabolic Acidosis

Summary: this observational study evaluates the potential benefits, costs and clinical outcomes of albumin over saline and other non-saline fluids in patients receiving large volume resuscitation.

currently, recommended resuscitation paradigms involve a "crystalloid-first" approach. this approach reserves more potent and potentially more toxic colloids for patients that have already been exposed to large amounts of crystalloid and may have also experienced a delay in correcting their shock. this observational retrospective cohort study aims to identify predictors for large volume resuscitation (lvr) and model the potential benefits, costs and clinical outcomes of albumin over saline and other non-saline fluids in patients receiving large volume resuscitation. further analyses will assess the risk of acute kidney injury (aki) and hyperchloremic metabolic acidosis (hca) associated with resuscitation fluid choice and examine long term outcomes such as development of end stage renal disease and post-discharge mortality up to 1 year following hospital discharge in patients treated with various fluid types this study will utilize data in a large, heterogeneous cohort (n=\~65,800) of critically ill patients admitted to the icu over a 12 year period at the university of pittsburgh medical center. the study population will consist of patients who receive large volume resuscitation (defined as \> 60ml/kg in a single 24 hour period) separated into analysis groups based on fluids administered during the defined 24 hour large volume resuscitation window. patients presenting with aki or hca prior to large volume resuscitation will be excluded. aki and "severe" aki will be diagnosed based on kdigo criteria within 72 hours following lvr. metabolic acidosis will be based on arterial blood gas measurements with a base deficit \> 2 meq/l, with patients having chloride as the ion contributing to the majority of the acidosis being diagnosed with hyperchloremic metabolic acidosis. mortality at 30, 90, and 365-days from icu admission will be ascertained using the social security death master file. propensity score models will be used to determine the adjusted relationship between these clinical outcomes and type of fluid resuscitation employed.

Eligibility criteria:
inclusion criteria: * critically ill patient admitted to icu exclusion criteria: * history of chronic dialysis and/or renal transplant * baseline serum creatinine \>= 4 mg/dl * develop aki or ma prior to lvr * received or fluids during lvr

Keywords: albumin resuscitation
stellate block versus nimodipine infusion for traumatic brain injury

Conditions: Traumatic Brain Injury

Summary: the study is designed to perform an intervention for enhancement of cerebral blood flow in patients with traumatic brain injury showing vasospasm through transcranial doppler


Eligibility criteria:
inclusion criteria: * patients more than 18 ys old with isolated head trauma and traumatic brain injury exclusion criteria: * • hemodynamic instability (mean abp less than 70 mmhg) * history of severe systemic disease including cardiopulmonary failure or hepatorenal failure * allergy to local anesthetics * coagulation disorders * abnormal neck structures disturbing normal anatomy as neck tumors