Kornimate/medical-research-clean huggingface dataset:
effects of pressure release of myofascial trigger points on mechanical neck pain.

Conditions: Myofascial Pain Syndrome of Neck; Trigger Point Pain, Myofascial; Myofacial Pain

Summary: the study aims to compare the effectiveness of myofascial trigger point treatment using pressure release versus a control group in patients with mechanical neck pain, randomly assigned. in both groups a protocol of therapeutic exercise and postural correction will be carried out

with the present investigation it is wondered whether the choice of manual therapy techniques, specifically the pressure release of myofascial trigger points in the upper trapezius and sternocleidomastoid muscles, provide significant benefits in combination with therapeutic exercise and postural hygiene (treatment group), as opposed to the unique application of therapeutic exercise and postural hygiene (control group), thus constituting a treatment of choice in patients with mechanical neck pain. a treatment protocol of one session per week will be carried out, and a follow-up two weeks after the end of the treatment protocol. if, as postulated, pressure release is more effective than the treatment received by the control group, the choice of this type of technique for myofascial pain syndrome would benefit a high percentage of people who often come asking for treatment in pain treatment centers. pressure release provides a painless manual stimulus, thus effectively resolving the symptomatology of myofascial trigger points without the need for invasive treatments or medication, which may have more contraindications.

Eligibility criteria:
inclusion criteria: * subjects between 18 and 55 years of age in order to avoid degenerative phenomena. * have suffered from neck pain at least once in the last month. * active or latent myofascial trigger points in the upper trapezius and sternocleidomastoid muscles. exclusion criteria: * patients with recent trauma (last 6 months) to the upper quadrant or spine. * patients with pathologies involving malignant neoplasms. * surgery on the trunk or upper limb in the last six months. * patients undergoing pharmacological or physiotherapy treatment at the time of the test. * pregnancy. * no myofascial trigger points in the upper trapezius or sternocleidomastoid muscles. * refusal to sign the consent form for the study or not being able to do so.

Keywords: upper trapezius sternocleidomastoid manual therapy trigger points myofascial pain syndrome therapeutic exercise
assessing better bottles for babies

Conditions: Pediatric Obesity; Weight Gain Trajectory; Infant Obesity

Summary: this study will use a 2 x 2 factorial design to test impact of two intervention strategies (bottle size and bottle opacity) on infant weight gain.

infants who gain weight rapidly have over 4 times higher odds of developing obesity as a child or adult; infants who are predominantly bottle-fed are at higher risk for excessive infancy weight gain and childhood obesity, yet there are not effective interventions to reduce excessive weight gain among infants who are bottle-fed. the investigators' preliminary work suggest that two novel intervention strategies are feasible and may reduce excessive infancy weight gain: reducing bottle size; and increasing bottle opacity. the investigators aim to test the independent and joint efficacy of these two intervention components among exclusively bottle-fed infants in a randomized, full factorial clinical trial. the investigators' primary objective is to measure the change in conditional weight gain z-score (cwgz) from birth to four months by study group. 4 groups are composed of two conditions: smaller bottles and opaque bottles, independently and in combination, via a 2x2 factorial trial design.

Eligibility criteria:
inclusion criteria: * child is 3 days old to 1 month old * greater than 37 weeks gestational age at birth * birth weight greater than 3% for sex-specific who growth standard * caregiver must plan to use local clinic as infant's primary medical home for first 6 months of life * caregiver must speak english or spanish as primary preferred language * caregiver age 18 years or older * caregiver must agree to use intervention bottles assigned during randomization and agree to stop using their existing bottles during the study period exclusion criteria: * multiple gestation * significant congenital anomaly or acquired or inherited condition directly affecting feeding, physiology, metabolism, or growth * feeding with soy-based, hydrolyzed, lactose-reduced, or elemental formula * weight loss greater than 95% for population reference in the first two weeks of life
diagnostic and prognostic blood markers in non specific low back pain

Conditions: Low Back Pain

Summary: • to compare the diagnostic and prognostic blood markers in acute and chronic nonspecific low back pain with healthy controls

* to compare the diagnostic and prognostic blood markers in acute and chronic nonspecific low back pain with healthy controls * to predict the diagnostic and prognostic blood markers on sleep, depression and anxiety in acute and chronic non specific low back pain. * to compare the effect of physical activity with blood markers in acute and chronic non specific low back pain.

Eligibility criteria:
inclusion criteria: 1. both male \& female patients 2. age group 18-60 years 3. diagnosed with nonspecific low back pain in acute/flared stage exclusion criteria: * any serious conditions like neurological conditions * any infection * tumor * spinal surgery * cognitive impairments * refusal to sign consent * patients taking any type of psychological management or rheumatologic disease would be excluded
[18f]flor (fc303) pet/ct imaging in patients with prostate cancer

Conditions: Metastatic Prostate Cancer

Summary: the study is an open label, single-arm study designed to evaluate the safety and diagnostic performance of \[18f\]flor (fc303) pet/ct imaging to determine the presence or absence of metastatic prostate cancer. .

this research is being done to determine whether the radioactive compound called \[18f\]flor (fc303) is safe and well-tolerated in patients with metastatic prostate cancer. participants in this study will have tests, exams and procedures that are for study purposes. participants will be in this study up to one month which will include up to three clinic visits. eligible patients diagnosed with metastatic prostate cancer will undergo a \[18f\]flor (fc303) pet-ct scan. this is the imaging procedure to assess where \[18f\]flor (fc303) has accumulated in the body.

Eligibility criteria:
inclusion criteria: * males ≥18 years of age. * subjects provide signed informed consent and confirm that they are able and willing to comply with all protocol requirements. * histologically confirmed adenocarcinoma of the prostate. * radiologic evidence of local recurrence or new or progressive metastatic disease demonstrated on anatomical imaging (ct, or mri), or whole-body bone scan within 4 weeks of day 1. * at least 2 weeks must have elapsed between last anti-cancer treatment administration and the imaging day. imaging day will be scheduled before initiation of new systemic therapy for recurrent and/or progressive metastatic disease * screening clinical laboratory values within normal limits or judged not clinically significant by the investigator. exclusion criteria: * subjects administered any radioisotope within five physical half-lives prior to study drug injection. * subjects with any medical condition or other circumstances that, in the opinion of the investigator, compromise obtaining reliable data, achieving study objectives, or completion.

Keywords: [18f]flor pet/ct prostate cancer j19145
physical exercise therapy vs relaxation in allogeneic stem cell transplantation (petra)

Conditions: Allogeneic Stem Cell Transplantation

Summary: the petra-study is a randomized, controlled trial and designed to examine the effects of an one-year physical exercise intervention on prognosis, side-effects and complications after allogeneic stem cell transplantation. the exercise intervention includes both, resistance and endurance training. patients assigned to the control group perform a relaxation program (progressive muscle relaxation - jacobsen) and have the same frequency of social contact.


Eligibility criteria:
inclusion criteria: * medical indication: allogeneic stem cell transplantation exclusion criteria: * orthopeadic limitations that hamper the exercise intervention * osseous degenerations that have an improved fracture risk

Keywords: allogeneic stem cell transplantation exercise survival fatigue quality of life cancer physical performance
the effects of body contouring: abdominoplasty and liposuction

Conditions: Subcutaneous Abdominal Fat; Abdominal Skin Elasticity; Rectus Muscle Diastasis; Unpleasant Body Contour

Summary: the data regarding the effects of aesthetic body contouring is insufficient. poor results may related to preoperative psychological distress. studies regarding eating disorder symptoms are lacking. therefore studies using standardized and validated are needed. we decided to prospectively study quality of life, psychological distress, and eating disorder symptoms in body contouring (abdominoplasty or liposuction) patient populations. used questionnaires are 15d quality of life, raitasalo's modification of the beck inventory, and the eating disorder inventory. we hypothesize that aesthetic body contouring plastic surgery has notable quality of life effects.


Eligibility criteria:
inclusion criteria: * patients requesting body contouring surgery exclusion criteria: * previous abdominal aesthetic surgery, simultaneous other aesthetic surgery at the same time
treatment effects from aerobic endurance training and maximal strength training in patients suffering from schizophrenia

Conditions: Schizophrenia; Cardiovascular Disease

Summary: this study investigates treatment effects from aerobic endurance training, maximal strength training and computer game on aerobic capacity, work efficiency and psychiatric symptoms in patients suffering from schizophrenia. the study is a controlled trial. the aim is to describe the population in respect to aerobic capacity and muscular strength. low aerobic capacity and muscular strength are important risk factors for cardiovascular disease (cvd). the study also aim to evaluate physical and psychiatric effects from physical training. effects from participation in physical training or computer game on symptoms, depression and quality of life will be investigated. data will be collected between october 2005 and august 2007.


Eligibility criteria:
inclusion criteria: schizophrenia, schizotypal and delusional disorders (f20-f29) according to the international statistical classification of diseases and related health problems, 10th revision (icd-10) prepared by the world health organization. patients must have stable antipsychotic medication for six weeks prior to participation. exclusion criteria: coronary artery disease, chronic obstructive pulmonary disease, not being able to perform physical treadmill testing and exercise, and less than 80% compliance to the training sessions. all subjects go through a physical health examination at inclusion.

Keywords: schizophrenia cardiovascular disease aerobic capacity mortality exercise
a study of the immune response to heplisav in healthy older adults

Conditions: Hepatitis B

Summary: this study will investigate the response of the immune system to a hepatitis b (hb) vaccine in healthy adults 50 to 70 years of age. this study is partially funded by the national institute of allergy and infectious diseases.

the purpose of this study is to examine how the immune system responds to vaccination with heplisav.

Eligibility criteria:
inclusion criteria: * 50 to 70 years of age, inclusive * in good health in the opinion of the principal investigator, based upon medical history and physical examination * serum negative for hbsag, anti-hbs, antibody to hepatitis b core antigen (anti-hbc), hepatitis c virus (hcv), and human immunodeficiency virus (hiv) * if female of childbearing potential, agree to consistently use a highly effective method of birth control from the screening visit through week 12/visit 10 exclusion criteria: * pregnant, breastfeeding, or planning a pregnancy * known history of an autoimmune disease * previously received any hepatitis b vaccine (approved or investigational) * body-mass index (bmi) \>30 kg/m2, diabetes mellitus (type 1 or 2), or other chronic medical condition that in the opinion of the principal investigator might interfere with the immune response to hepatitis b vaccination

Keywords: heplisav
reminiscence-based life review on copying with existential suffering among older cancer survivors

Conditions: Existential Suffering; Meaning of Life; Cognitive Function; Psychological Distress; Social Support

Summary: target issue: cognitive impairment in older cancer survivors is highly prevalent and the co-existing neuro-psychiatric symptoms, particularly depression, would further complicate the psychosocial consequence of existential suffering. however, no reminiscence-based interventions are specifically developed for older people with cancer have been developed and evaluated. target population: cancer survivors aged 65 years old and above with a mild cognitive impairment identified by the hk-moca 5-min protocol cognitive assessment. intervention: this research project aims to implement a brief reminiscence-based intervention that includes six reminiscence chatting sessions among older cancer survivors. the proposed reminiscence-based intervention has great potential to provide psychological and spiritual care as well as comfort to those who are weak, aged and are in need of assistance. study objectives: 1. to evaluate the effect of a reminiscence-based life review intervention on copying with existential suffering including meaning of life (primary outcome), cognitive function, psychological distress and social support (secondary outcomes) in older cancer survivors 2. to explore older cancer survivors' experience of the intervention regarding the impact of the intervention on their existential suffering study method: the investigator will recruit 116 voluntary elder patients from the outpatient oncology clinics of the queen mary hospital to participate in the study. they will be individually randomized at a 1:1 ratio to receive usual care or the brief reminiscence-based intervention at home. outcomes will be assessed at baseline (t0), post-intervention (t1), and 6-week follow-up (t2). a qualitative interview regarding the feedback on the intervention will be undertaken only in the intervention group.


Eligibility criteria:
inclusion criteria: * aged ≥ 65 years * diagnosed with stage i-iii non-metastatic cancer * completed primary treatment with curative intent (surgery, chemotherapy, and/or radiation therapy) 6 months to 5 years prior to baseline assessments with no recurrence or occurrence of additional cancers * identified as mild cognitive impairment by the hk-moca 5-min protocol cognitive assessment (≤ 7th age and education corrected percentile cutoff score) exclusion criteria: * inadequate written and verbal cantonese and/or english comprehension for study activities * diagnosed with dementia
understanding covid-19 testing knowledge and practices among 2-1-1 helpline callers

Conditions: Communication; Health Knowledge, Attitudes, Practice

Summary: the purpose of this study is to identify promising health education strategies and culturally appropriate messages for use by 2-1-1 practitioners to promote coronavirus disease of 2019 (covid) testing behaviors. previous study findings and evidence-based health communication and education tactics were integrated to create an interactive learning module that includes four narrative scenarios, illustrations, and accompanying questions and responses that inform the audience about covid testing guidelines. the study will test the effectiveness of the interactive learning module with 2-1-1 callers (n=300) in connecticut, north carolina, and nebraska. participants' contact information will be shared with us by 2-1-1 with the participants' given consent. the study team will send the potential participant via text message a link to a survey that includes a screen where they will provide informed consent. those who provide consent will be randomly assigned to receive one of two surveys. the inclusion of the interactive learning module is what varies across the surveys. an experimental group will receive the learning module with a study team-developed pre- and post-survey, and the control group will receive only the study team-developed pre- and post-survey. the post-survey contains questions regarding information covered in the interactive learning module. it is hypothesized that those who complete the interactive learning module in the experimental group will score better on the post-survey questions when compared to the control group. all participants, regardless of experimental or control condition, will receive an information sheet with the most up-to-date scientific guidelines for covid testing.


Eligibility criteria:
inclusion criteria: * individuals who called 211 in connecticut, nebraska, or north carolina on behalf of themselves or their families * must be 18 or older * must have english language proficiency * must be willing to be contacted via text messages or email exclusion criteria: * n/a
effect of intracameral phenylephrine/ketorolac on intraoperative pain

Conditions: Pain Reduction

Summary: to compare the effect of intraoperative intracameral omidria (phenylephrine and ketorolac 1.0%/0.3%) verses 1% lidocaine on pain reduction during and after cataract surgery.


Eligibility criteria:
inclusion criteria: * individuals with a cataract in the surgical eye exclusion criteria: * patients that have previously exhibited sensitivities to acetylsalicylic acid, phenylacetic acid derivative, and other nonsteroidal anti-inflammatory drugs (nsaids) * those with a past medical history of asthma * those systemically using opioids or nonsteroidal anti-inflammatory drugs * those prescribed additional topical mydriatics, topical steroids, pilocarpine, or prostaglandins in the week preceding surgery * those with a history of alpha-1-adrenergic antagonist use * those with excisional, intraocular surgery in the planned surgical eye in the preceding year * those with a history of iris damage * those requiring iris expanding device or those with an acute or chronic uncontrolled eye condition, or those unable to effectively remember surgery or complete the post-operative assessment. * additionally, individuals less than 21 will be excluded.
effectiveness of one-minute versus two-minute cryoanalgesia in nuss surgery

Conditions: Pectus Excavatum; Funnel Chest

Summary: intercostal nerve cryoanalgesia has become a popular method for managing postoperative pain after nuss procedure, showing greater effectiveness compared to epidural anesthesia and patient-controlled analgesia. however, the optimal duration of cryoanalgesia remains unknown. most protocols use a two-minute cryoablation, although histological studies show similar changes with both one-minute and two-minute applications. this is a pilot, single-center, randomized, double-blind study comparing the effectiveness of one-minute versus two-minute cryoanalgesia in treating pain in patients undergoing correction of pectus excavatum using the nuss procedure. the aim of the project is to evaluate the validity of the research procedure and determine the sample size for the main study. preliminary data on postoperative pain intensity, opioid consumption, duration of surgery, length of hospital stay, and complications will be analyzed.


Eligibility criteria:
inclusion criteria: * pectus excavatum repair with mirpe * written consent for corrective surgery with intraoperative cryoanalgesia * written consent to participate in the study * age \>12 and \< 18 years exclusion criteria: * history of previous thoracic surgeries * reoperation for chest deformity * contraindication for cryoanalgesia * presence of other conditions that may affect the course of the procedures and the assessment of their effectiveness and safety

Keywords: cryoanalgesia pain management pectus excavatum funnel chest
bilateral monofocal versus monofocal-edof iol implantation: quality of vision comparison

Conditions: Cataract

Summary: the goal of this clinical trial is to compare visual quality after cataract surgery between two groups: bilateral monofocal intraocular lenses (iol) and monofocal and contralateral extended depth-of-focus (edof) iol implantation. the main question it aims to answer is: • does the combination of both monofocal and edof iols presents an advantage over bilateral monofocal iol implantation in the daily life of patients undergoing cataract surgery without the disadvantages of bilateral edof iol implantation? participants will: * be randomised in either bilateral monofocal group or monofocal and edof group * undergo visual acuity testing with and without correction at all distances * be asked to complete a quality of vision questionnaire * undergo non-invasive examinations to measure residual astigmatism, contrast sensitivity, straylight, optical aberrations, reading spead.


Eligibility criteria:
inclusion criteria: * patients aged between 50 and 90 years with bilateral cataract without concomitant exclusion criteria exclusion criteria: * prior refractive surgery * patients with corneal opacities, retinopathy, opticopathy, glaucoma, uveitis and amblyopia * patients with corneal astigmatism greater than 3 diopters (d) * patients with expected postoperative astigmatism higher than 0.50d * prior ocular surgery in the last six months * patients with prior unilateral cataract surgery