Kornimate/medical-research-clean huggingface dataset:
efficacy of prontosan solution on chronic ulcers

Conditions: Pressure Ulcer; Chronic Wound Care; Wound Cleansing

Summary: the purpose of this study is to evaluate the efficacy of prontosan® wound irrigation solution compared with standard isotonic solution on infammation reduction and wound bed cleansing of chronic pressure or vascular leg ulcers.


Eligibility criteria:
inclusion criteria: * male and females aged at least 18 with pressure ulcer stage 2-3 npuap (national pressure ulcer advisory panel 1989)or subcutaneous vascular ulcer with inflammation and/or biofilm and/or slough * braden index at baseline\>=10 * ulcer area\<80 cm2 * ability to give an informed consent exclusion criteria: * braden index at baseline\<10 * current therapy with corticosteroids or immunosuppressor or radiotherapy * sensitivity to any of the components of prontosan® solution * diabetic foot ulcer * current use of local antiseptics on the wound bed * previous recruitment of another ulcer in the trial
radiotherapy and anti-pd-1 in low-risk es-enktcl

Conditions: Early-stage; Extranodal NK-T-Cell Lymphoma, Nasal and Nasal-Type

Summary: the current study is a phase ii multi-center single arm trial to evaluate the efficacy and safety of adding anti-pd-1 antibody in an inductive and concurrent way to radiotherapy in early-stage low-risk extranodal nk/t cell lymphoma, nasal type


Eligibility criteria:
inclusion criteria: * biopsy proved extranodal nk/t cell lymphoma * no previous anti-cancer treatment * measurable lesion on baseline pet/ct and mri * stage i * normal serum ldh level * primary tumor invasion (pti) absence * ecog ps 0-1 * sufficient organ functions exclusion criteria: * other mature t- or nk- lymphoma * hemophagocytic lymphohistiocytosis * primary cns lymphoma or cns-involved lymphoma * history of malignancy except for cutaneous basal-/squamous- cell carcinoma or cervical carcinoma in situ 3 years prior to study treatment

Keywords: nk/t-cell lymphoma, nasal and nasal-type radiotherapy anti-pd-1 antibody
renal denervation by allegro system in patients with resistant hypertension

Conditions: Renal Denervation; Resistant Hypertension; Standard Medication

Summary: the purpose of allegro-htn trial is to evaluate the safety and effectiveness of renal denervation in subjects with resistant hypertension by using allegro renal denervation system


Eligibility criteria:
inclusion criteria: * age 18 - 65 years at time of randomization * stable medication regimen including 3 or more antihypertensive medications of different classes, including a diuretic (with no changes for a minimum of 4 weeks prior to screening) and no expected changes for at least 6 months * 1) office sbp and/or dbp ≥160/100 mm hg ( ≥ 150/95 mmhg for type ii diabetic patients) , 2) abpm 24 hour average sbp and/or dbp ≥140 and/or 90 mmhg * main renal arteries with ≥4 mm diameter or with ≥20 mm treatable length (by visual estimation) * egfr≥45 ml/min/1.73 m2 * written informed consent exclusion criteria: * type 1 diabetes mellitus * secondary hypertension * has an implantable cardioverter defibrillator (icd) or pacemaker * myocardial infarction, unstable angina pectoris, syncope, or a cerebrovascular accident within 6 months of the screening period * intravascular thrombosis or unstable atherosclerotic plaques * has hemodynamically significant valvular heart disease * pregnant, nursing, or planning to be pregnant * any serious medical condition that may adversely affect the safety of the participant or the study * currently enrolled in another investigational drug or device trial angiographic exclusion criteria: * renal artery stenosis (≥50%) or renal artery aneurysm in either renal artery * history of prior renal artery intervention including balloon angioplasty or stenting * multiple renal arteries where the main renal artery is estimated to supply \<75% of the kidney * main renal arteries with \<4 mm diameter or with \<20 mm treatable length (by visual estimation) * renal artery abnormalities
safety, pharmacokinetics (pk), and efficacy of buprenorphine transdermal system (btds) in children

Conditions: Pain

Summary: the purpose of this study is to characterize the safety, pk, and efficacy of btds in patients of ages 7 to 16 years.

a study of safety, pk, and efficacy of btds in patients of ages 7 to 16 years, inclusive, who require continuous opioid analgesia for moderate to severe pain.

Eligibility criteria:
inclusion criteria include: * male and female patients, 7 to 16 years of age, inclusive, with malignant and/or nonmalignant moderate to severe pain requiring or anticipated to require continuous, around-the-clock, opioid treatment for at least 2 weeks (based on the investigator's judgment); * patients must have written informed consent provided by the parent or legal guardian and assent provided by the patient, when appropriate; * patients on incoming opioids must be taking ≤ 80 mg/day morphine or equivalent if aged 12 to 16 years or ≤ 40 mg/day morphine or equivalent if aged 7 to 11 years prior to the screening visit; * patients and patient's parent/caregiver must be compliant with the protocol, ie, must be able to perform study assessments and understand and complete the age-appropriate scale to rate pain intensity. patients must not have a cognitive developmental delay or any other condition that would preclude them from completing the age-appropriate pain scale. exclusion criteria include: * patients who are allergic to buprenorphine or have a history of allergies to other opioids (this criterion does not include patients who have experienced common opioid side effects \[eg, nausea, constipation\]) or who have allergies or other contraindications to transdermal delivery systems or patch adhesives; * patients with a dermatological disorder, including burn and skin graft sites, at any relevant patch application site that would preclude proper placement and/or rotation of btds patches; * patients with evidence of impaired renal function; * patients with hepatic impairment; * patients with history of seizures; * patients with intracranial pressure; * patients who have a history of sleep apnea within the past year; * patients who require mechanical ventilation during study treatment period, are cyanotic, or who have unstable respiratory disease; * patients with clinically significant structural heart disease or a pacemaker; * patients with clinically unstable cardiac disease; * patients who receive or anticipate to receive investigational medication/therapy during study drug treatment period. other protocol-specific inclusion/exclusion criteria may apply.

Keywords: pain opioid analgesia moderate to severe pain
treatment of neck pain with transcranial direct current stimulation

Conditions: Cervical Syndrome

Summary: this study aim to investigate the effects of transcranial direct current stimulation for improving pressure pain thresholds (ppts), range of motion,neck disability index, the multidimensional health related quality of life (sf-12) and the multidimensional health related quality of life and pain in patients with mechanical neck pain (np).

fifty-four participants with np will randomly allocated to either an transcranial direct current stimulation (ten sessions) or transcutaneous electric nerve stimulation (tens) (ten sessions) during two weeks. . visual analogue scale (vas), neck disability index ( ndi), range of motion and (crom), questionnaire sf-12 and ppts in sub-occipital and upper trapezius muscles were measured at baseline, at the end of treatment and at 1 month follow-up. t-tests and a repeated-measures multivariate analysis of variance (rm-manova) were used for vas, crom and ppts, respectively.

Eligibility criteria:
inclusion criteria: * patients of both sexes, * aged between 18 and 60 years, in an * active state of pain and diagnosed with a month of evolution. exclusion criteria: - patients who are pregnant, have pacemaker and those surgically operated cervical spine - patients who have been treated with transcranial direct current stimulation a month earlier.

Keywords: neck pain physical therapy modalities manual therapy massage transcranial direct current stimulation transcutaneous electrical nerve stimulation
power training combined with interval treadmill training

Conditions: Cerebral Palsy; Central Nervous System Diseases; Brain Damage, Chronic

Summary: ambulatory children with cerebral palsy (cp) experience walking limitations which negatively influence their ability to physically participate in day to day life. the investigators propose that impaired muscle power generation is the key limiting factor affecting walking activity and participation. this proposal represents a combined approach where participants undergo resistance training for muscle power generation in combination with locomotor treadmill training that is based on typical pediatric walking and activity patterns rather than adult protocols, which are endurance or time-based. therefore, the primary objective of this randomized controlled trial is to determine the effect of lower extremity power training combined with interval treadmill training (pt³) on functional walking capacity and community-based activity and participation in children with cp. we hypothesize that remediating the most pronounced muscle performance impairment (i.e., muscle power) with power training combined with a task- specific approach to walking that is developmentally appropriate will have a significant effect on walking capacity and performance.

the primary purpose of this randomized controlled trial is to test the effect of power training combined with interval treadmill training (pt³) on walking capacity and performance in children with cp with walking limitations. to identify key muscular mechanisms associated with improved walking mobility, the effects of pt³ on muscle performance and architecture will be examined. the premise of the pt³ protocol is that a combined impairment and task-specific approach that is developmentally appropriate and targets muscle power deficits specifically, is necessary to drive changes in both clinic and community-based walking activity. in this randomized multi-site clinical trial, 48 ambulatory participants with cp will receive either pt³ or an equivalent dosage of traditional strength training combined with traditional treadmill training (comparison group) for 24 sessions, 3 times per week for 8 weeks. outcomes will be collected at baseline and immediately post-treatment. short and long-term retention effects will be assessed at 2 and 6 months post.

Eligibility criteria:
inclusion criteria: * diagnosis of bilateral spastic cerebral palsy (cp) * age 10 to 17 years inclusive * gmfcs levels i, ii, or iii exclusion criteria: * orthopedic or neurosurgery less than 12 months prior to enrollment * injection therapies (phenol, botulinum toxin) less than 3 months prior to enrollment * lacking greater than 25 degrees of knee extension

Keywords: muscle weakness muscle power resistance training treadmill training
ablation of supraventricular arrhythmias with as low as reasonably achievable x-ray exposure

Conditions: Tachycardia, Supraventricular

Summary: observational study is to demonstrate a clinically significant reduction of ionizing radiation exposure during transcatheter ablation of supraventricular tachycardias using the ensite precision mapping system in a real-world clinical setting without compromising efficacy and safety.


Eligibility criteria:
inclusion criteria: * male or female patients ≥ 18 years of age * patient indicated for supraventricular arrhythmias ablation according to the current guidelines * patient is willing to provide written informed consent. exclusion criteria: * patient is pregnant. * contraindications to ionizing radiation exposure * patient's life expectancy is less than 1 year * associated complex congenital heart disease * cardiac implantable electric devices * known pathological venous access to the heart

Keywords: supraventricular tachycardia radiation exposure
suicidal poisoning in emergency units

Conditions: Poisoning

Summary: poisoning is the deterioration of the body's functions by the ingestion of any substance being toxic to the body or by overdosing a nontoxic substance. poisoning cases may vary according to the geographical and seasonal characteristics of the region, sociocultural structure of the population, life index and the age groups. worldwide, intentional self-poisoning (isp) is the most common form of suicide attempt and the most common method that results in medical hospitalization.

questionnaire is prepared including the following items: demographic data: gender -age-marital status -occupation- socioeconomic state -special habit -history of psychiatric innless-history of chronic diseases-history of drug dependence -previous suicidal attempts-toxic substance used in suicide- time of poisoning, season and time of arrival . data regarding poisoned substance: dose, type of the substance used and rout of administration. presenting symptoms of intoxication and management complete clinical examination: general condition: conscious level and vital signs. local examination: chest, heart, abdomen, etc. investigation: (arterial blood gases - ecg -otherwise according to case presentation) prognosis: complete recovery, complications, death.

Eligibility criteria:
inclusion criteria: * suicidal poisoning cases exclusion criteria: * other causes of suicide
administration of ars-1 or albuterol in subjects with persistent asthma

Conditions: Asthma

Summary: ars-1 is being developed for patients as a needleless alternative route of epinephrine administration for the management of refractory asthma symptoms.


Eligibility criteria:
inclusion criteria: * 1. is a male or female subject between the ages of 12 and 65 years, inclusive. * 2. asthma that has been stable for at least four weeks prior to screening as defined by clinical history. * 3. reversible bronchoconstriction. * 4. has body weight more than 30 kilogram (kg) and body mass index between 18 and 34 kg/m², inclusive. * 5. has no medical history of hypertension and cardiovascular disease in the last 10 years. * 6. at screening, has stable vital signs. exclusion criteria: * 1. history of clinically significant gastrointestinal, renal, hepatic, neurologic, hematologic, endocrine, oncologic, pulmonary, immunologic, psychiatric, or cardiovascular disease or any other condition. * 2. patients receiving beta blocker. * 3. has any clinically significant medical condition or physical exam finding as deemed inappropriate by the investigator. * 4. has abnormal cardiovascular exam at screening including any prior history of myocardial infarction or clinically significant abnormal electrocardiogram. * 5. has mucosal inflammatory disorders. * 6. has had significant traumatic injury, major surgery or open biopsy within 30 days prior to study screening.
effect of mandibular complete dentures relining on occlusal force distribution

Conditions: Occlusion

Summary: evaluation of occlusal force distribution was carried out with the aid of t-scan device (tekscan inc., south boston, ma, usa) for mandibular complete dentures before and after relining with long term soft liner for controlled type 2 diabetic patients.

a crossover clinical study was carried out with previously constructed and used conventional complete dentures before relining with soft denture liners and then with the same dentures after relining with soft denture liners. the study sample included 50 males completely edentulous contributors, all patients were controlled type 2 diabetes during the study period. all selected patients had previously constructed and used conventional heat cured acrylic resin complete dentures for not less than two years with history of retention and stability problems of mandibular dentures. mandibular complete dentures had received the essential prosthetic adjustments aiming to achieve optimal retention, maximum stability and the necessary occlusal contacts. the first occlusal parameters were recorded before denture relining. relining of mandibular dentures was performed and patients were comfortably using their relined mandibular complete dentures for at least three months and the retention and stability of the conventional dentures were assessed before second recording of occlusal parameter. the evaluation of occlusal force distribution was carried out with the aid of t-scan device (tekscan inc., south boston, ma, usa). the first record was recorded before denture relining and the second record was three months after denture relining

Eligibility criteria:
inclusion criteria: * all patients were controlled type 2 diabetes * all patients were non-smokers * had an angle class i maxillo-mandibular relationship. * patients having moderately developed maxillary and mandibular alveolar ridges lined with firm mucoperiostea. exclusion criteria: * history of temporomandibular disorders, or neuromuscular disorders like; bruxism or severe clenching * presence of medical problems or severe chronic diseases * any intraoral soft or hard tissue pathology.

Keywords: complete dentures relining occlusal force t scan system
tavns improves the symptoms of patients with moderate to severe cp/cpps

Conditions: Chronic Prostatitis

Summary: this trial aims to evaluate the efficacy and safety of transcutaneous auricular vagus nerve stimulation (tavns) for moderate to severe chronic prostatitis/chronic pelvic pain syndrome (cp/cpps). this study is a prospective, randomized, controlled trial. a total of 68 patients with cp/cpps will be recruited. after baseline assessment, the patients will be randomized into tavns group (n = 34) and sham-tavns group (n = 34). the intervention of two group will last for 4 weeks with a 8-week follow-up period after the treatment. the national institutes of health chronic prostatitis symptom score index (nih-cpsi), international prostate symptom score scale (ipss), european quality of life-5 dimensions questionnaire (eq-5d), self-rating anxiety scale (sas) and self-rating depression scale (sds) will be assessed. the adverse events during the whole study will be recorded detailedly.


Eligibility criteria:
inclusion criteria: * consistent with the diagnostic criteria of cp/cpps of eau or cau, the clinical manifestations were recurrent and persistent prostate pain accompanied by abnormal urination and psychiatric symptoms, without infection or other obvious pathological conditions. the pain symptoms were mainly manifested as pain in the surrounding tissues centered on the prostate, and pain, swelling or discomfort in the scrotum, testis, lower abdomen, perineum, lumbosacral area, and medial thigh. abnormal urination was characterized by frequent urination, urgent urination, urination pain, urethral burning, residual urination or white discharge from the urethra at the end of urination or defecation in the morning. the neuropsychiatric symptoms included dizziness and tinnitus, insomnia and dreams, anxiety and depression, and even impotence, premature ejaculation, and spermatorrhea. symptoms lasting more than 3 months in the last six months * 18 ≤ age ≤ 50 years old * nih-cpsi ≥15 (patients with moderate to severe cp/cpps) * signed informed consent and voluntarily participated in the trial exclusion criteria: * patients with other diseases that cause urinary symptoms were excluded: such as benign prostatic hyperplasia, testicular and epididymal and spermatic cord diseases, overactive bladder, neurogenic bladder, interstitial cystitis, glandular cystitis, sexually transmitted diseases, bladder tumors such as carcinoma in situ, prostate cancer, urinary male reproductive system tuberculosis, anorectal diseases, lumbar diseases, central and peripheral neuropathy, etc * patients with severe diseases of the heart, liver, kidney, hematopoietic system and poor nutritional status * patients with severe mental and emotional disorders, who were unable to cooperate with the study * patients who have been treated with cp/cpps regimen in the past 4 weeks
relationship between periodontal health status, body mass index and quality of diet in a sample of adult patients.

Conditions: Conditions Influencing Health Status

Summary: the study is a cross-sectional study investigating the relationship between periodontal health condition, body mass index and quality of diet on adult egyptian dental patients attending the oral diagnostic center at faculty of dentistry, cairo university. the faculty of dentistry, cairo university is an open public facility, a tertiary healthcare and a referral center

* dental patients will be recruited in a consecutive manner from the outpatient diagnostic center, faculty of dentistry, cairo university. * medical history will be taken, thorough oral examination will be done, and a full questionnaire will be filled for each patient. * before filling the questionnaire, the aim of the study will be explained to the patient and the patient's acceptance to participate in the survey will be received. * non-respondent patients or patients refusing to participate will be reported with the cause of their refusal. * the questionnaire will be filled through a face-to-face personal interview with the patient using simple, short, easily comprehended questions. * full questionnaire will be filled, then full mouth periodontal examination and charting will be done for each patient. * the interview questions will be prepared in english, translated into arabic and then reverse translated by a certified translator to ensure accuracy. * all the interviews will be done by the same investigator. * convetional clinical examination will be held on a dental unit using the light of the unit and a mirror. * periodontal health status will be evaluated by full mouth charting using unc 15 periodontal probe, including assessment of probing depth (pd), clinical attachment level (cal), bleeding on probing (bop), plaque index (pi), body mass index (bmi) and health eating index (hei). * the questionnaire which was applied in study will include the following: 1. questions including section for demographic information of age, gender, marital status, income, weight, length. 2. dietary habits were self-reported through completion of a short form of a validated food frequency questionnaire (ruiz-cabello et al., 2017).

Eligibility criteria:
inclusion criteria: 1. patients whose age is between 18-70 years old. 2. provide informed consent. 3. patient have at least 20 natural teeth. 4. patient had no received periodontal treatment within previous 4 months. exclusion criteria: 1. individuals with chronic systemic diseases such as cancer, osteoporosis, endocrine and hematological pathologies. 2. patients having problem in opening their mouth or undergoing inter-maxillary fixation where oral examination will not be possible. 3. pregnant women. 4. patients diagnosed with psychiatric problems or intoxicated with alcohol or drugs. 5. patients with orthodontic appliances. 6. patient had autoimmune condition. 7. all patients require prophylaxis at least those attending the diagnostic center.