collecting and storing tissue samples from patients with head and neck cancer

Conditions: Head and Neck Cancer

Summary: rationale: collecting and storing samples of tissue, blood, and saliva from patients with cancer to study in the laboratory may help the study of cancer in the future. purpose: this laboratory study is collecting and storing tissue samples from patients with head and neck cancer.

objectives: * establish a tissue/specimen bank of biologic specimens collected from patients with proven or suspected head and neck cancer. * establish a database to link materials acquisition and pathologic and clinical information on these patients. * correlate clinical-pathological findings on these patients with future scientific studies using the patient database. * test new hypotheses as they emerge. outline: this is a prospective, multicenter study. patients enrolled on active radiation therapy oncology group clinical trials undergo biopsy or surgical resection of head and neck tumors or premalignant lesions at participating institutions. tissue and other specimens collected at the time of biopsy or surgery are submitted to the head and neck cancer tissue/specimen bank which acts as a central repository for processing, storing, and preserving patient specimens for translational research. tissue samples include paraffin-embedded blocks or fresh or frozen samples of normal squamous mucosa, tumors, or premalignant lesions of the upper aerodigestive tract. other specimens for tissue banking include serum, plasma, and lymphocytes isolated from peripheral blood, as well as samples of patient saliva. cells obtained from tissue bank specimens may also be used to establish cell lines for future research. projected accrual: an unlimited number of specimens will be accrued for this study.

Eligibility criteria:
disease characteristics: * confirmed or suspected head and neck cancer * primary site recurrence allowed * potentially eligible for or participating in an active radiation therapy oncology group treatment clinical trial patient characteristics: * zubrod performance status 0-1 prior concurrent therapy: * see disease characteristics * concurrent radiotherapy, drug therapy, biopsy, or surgery allowed

Keywords: stage i squamous cell carcinoma of the hypopharynx stage ii squamous cell carcinoma of the hypopharynx stage iii squamous cell carcinoma of the hypopharynx stage iv squamous cell carcinoma of the hypopharynx stage i squamous cell carcinoma of the larynx stage ii squamous cell carcinoma of the larynx stage iii squamous cell carcinoma of the larynx stage iv squamous cell carcinoma of the larynx stage i verrucous carcinoma of the larynx stage ii verrucous carcinoma of the larynx stage iii verrucous carcinoma of the larynx stage iv verrucous carcinoma of the larynx stage i basal cell carcinoma of the lip stage ii basal cell carcinoma of the lip stage iii basal cell carcinoma of the lip stage iv basal cell carcinoma of the lip stage i mucoepidermoid carcinoma of the oral cavity stage ii mucoepidermoid carcinoma of the oral cavity stage iii mucoepidermoid carcinoma of the oral cavity stage iv mucoepidermoid carcinoma of the oral cavity stage i verrucous carcinoma of the oral cavity stage ii verrucous carcinoma of the oral cavity stage iii verrucous carcinoma of the oral cavity stage iv verrucous carcinoma of the oral cavity stage i adenoid cystic carcinoma of the oral cavity stage ii adenoid cystic carcinoma of the oral cavity stage iii adenoid cystic carcinoma of the oral cavity stage iv adenoid cystic carcinoma of the oral cavity stage i squamous cell carcinoma of the lip and oral cavity stage ii squamous cell carcinoma of the lip and oral cavity stage iii squamous cell carcinoma of the lip and oral cavity stage iv squamous cell carcinoma of the lip and oral cavity metastatic squamous neck cancer with occult primary stage i lymphoepithelioma of the nasopharynx stage ii lymphoepithelioma of the nasopharynx stage iii lymphoepithelioma of the nasopharynx stage iv lymphoepithelioma of the nasopharynx stage i squamous cell carcinoma of the nasopharynx stage ii squamous cell carcinoma of the nasopharynx stage iii squamous cell carcinoma of the nasopharynx stage iv squamous cell carcinoma of the nasopharynx stage i lymphoepithelioma of the oropharynx stage ii lymphoepithelioma of the oropharynx stage iii lymphoepithelioma of the oropharynx stage iv lymphoepithelioma of the oropharynx stage i squamous cell carcinoma of the oropharynx stage ii squamous cell carcinoma of the oropharynx stage iii squamous cell carcinoma of the oropharynx stage iv squamous cell carcinoma of the oropharynx stage i esthesioneuroblastoma of the paranasal sinus and nasal cavity stage ii esthesioneuroblastoma of the paranasal sinus and nasal cavity stage iii esthesioneuroblastoma of the paranasal sinus and nasal cavity stage iv esthesioneuroblastoma of the paranasal sinus and nasal cavity stage i inverted papilloma of the paranasal sinus and nasal cavity stage ii inverted papilloma of the paranasal sinus and nasal cavity stage iii inverted papilloma of the paranasal sinus and nasal cavity stage iv inverted papilloma of the paranasal sinus and nasal cavity stage i midline lethal granuloma of the paranasal sinus and nasal cavity stage ii midline lethal granuloma of the paranasal sinus and nasal cavity stage iii midline lethal granuloma of the paranasal sinus and nasal cavity stage iv midline lethal granuloma of the paranasal sinus and nasal cavity stage i squamous cell carcinoma of the paranasal sinus and nasal cavity stage ii squamous cell carcinoma of the paranasal sinus and nasal cavity stage iii squamous cell carcinoma of the paranasal sinus and nasal cavity stage iv squamous cell carcinoma of the paranasal sinus and nasal cavity stage i salivary gland cancer stage ii salivary gland cancer stage iii salivary gland cancer stage iv salivary gland cancer recurrent squamous cell carcinoma of the hypopharynx recurrent squamous cell carcinoma of the larynx recurrent squamous cell carcinoma of the lip and oral cavity recurrent squamous cell carcinoma of the nasopharynx recurrent squamous cell carcinoma of the oropharynx recurrent squamous cell carcinoma of the paranasal sinus and nasal cavity recurrent adenoid cystic carcinoma of the oral cavity recurrent basal cell carcinoma of the lip recurrent esthesioneuroblastoma of the paranasal sinus and nasal cavity recurrent inverted papilloma of the paranasal sinus and nasal cavity recurrent lymphoepithelioma of the nasopharynx recurrent lymphoepithelioma of the oropharynx recurrent midline lethal granuloma of the paranasal sinus and nasal cavity recurrent mucoepidermoid carcinoma of the oral cavity recurrent salivary gland cancer recurrent verrucous carcinoma of the larynx recurrent verrucous carcinoma of the oral cavity recurrent metastatic squamous neck cancer with occult primary