Kornimate/medical-research-clean huggingface dataset:
recurrent inguinal hernia treatment - lichtenstein versus laparoscopic totally extraperitoneal preperitoneal hernioplasty

Conditions: Recurrent Inguinal Hernia

Summary: the study aims at detecting possible differences between an open (lichtenstein) and a video-assisted (tep) technique in treating recurrent inguinal hernia. the differences monitored are further recurrence and chronic pain as well as primary complications.


Eligibility criteria:
inclusion criteria: * recurrent inguinal hernia * willing to participate exclusion criteria: * unwilling to participate * bilateral hernia * preference towards either treatment arm
hepatocellular carcinoma liver organoids

Conditions: Hepatocellular Carcinoma

Summary: the goal of this interventional study is to create hepatocellular carcinoma organoids from liver bioptic samples of individuals with hepatocellular carcinoma. the main questions it aims to answer are: * the feasibility of hepatocellular carcinoma organoids integrated with host gut microbiota and peripheral blood mononuclear cells * the molecular pattern of the organoid tumor microenvironment * the in vitro therapeutic response of hepatocellular carcinoma organoids


Eligibility criteria:
inclusion criteria: * ability to express informed consent * patients ≥ 18 years of age * radiological diagnosis of hepatocellular carcinoma (hcc) exclusion criteria: * patients \<18 years of age * contraindications for liver biopsy: ascites, platelet count \ 1.7 * active viral infection * refusal to give informed consent for the study
diabetic care self-management mobile health application among diabetes mellitus clients in malaysia

Conditions: Diabetes Mellitus, Type 2

Summary: the main purpose of this study is to explore the effect of diabetic care self-management mobile health application in behavioral modification i.e foot care behaviour and dietary behaviour among diabetic clients in malaysia. diabetic care self-management mobile health application is a mobile health (mhealth) application program aiming for primary care in health prevention and promotion activity. the program is developed by the researcher through the literature review conducted. the program is evaluated through a randomized controlled trial study design.


Eligibility criteria:
inclusion criteria: * past readings of a1c more than 6.5% (ministry of health malaysia, 2015). * has at least stage 1 or above for the risk of foot ulcer development. the risk will be identified through diabetic foot screening. the screening will be carried out by using inlow's 60 second diabetic foot screen. * age of 18 to 65 years old. since the study is using mobile health applications, technology literate is an important factor to see the effect of mhealth on behaviour modification process. if the patient is more than 65 years old, the patient might have some difficulties in using mobile health intervention. meanwhile, for the patient less than 18 years old, guardian permission is required prior to study enrolment. * have no history of diabetic foot ulcers. * able to independently perform self-care. * able to use a mobile application program. * own an android phone. * no vision or hearing problem may interfere with the process of data collection and intervention carried out. * able to communicate in either english or bahasa malaysia (a native and official language of the country) exclusion criteria: * the patient that did not come for the follow-up care at week 5. for instance, the patient may have other matters on the day of follow-up up which required their urgent attention and not able to come for the follow-up, or is stay outside of the area during the day of follow up. * have difficulty in performing foot care during in the middle of the intervention period. for example, the client may get sick due to hypoglycemic or hyperglycemic attack which stopped them from being able to perform the foot care behaviour. * the patient is diagnosed with any cognitive and perceptual decline function
kuvan therapy in phenylketonuria (pku): the effect of blood phenylalanine concentration on kuvan response

Conditions: Phenylketonuria

Summary: the investigators will investigate the effect of blood phenylalanine on kuvan responsiveness in the same patients with pku when their blood phenylalanine concentrations are altered by diet. lowering blood phenylalanine concentrations in kuvan non-responsive patients with pku will increase the frequency of kuvan responsiveness.


Eligibility criteria:
inclusion criteria: * all patients with a diagnosis of phenylketonuria * patients who are over the age of 4 years, * patients with a fasting blood phenylalanine ≥600µmol/l exclusion criteria: * female patients who are pregnant or attempting to become pregnant * children under four years of age * concurrent disease of condition that would interfere with study participation or safety such as history of neurological compromise or major medical, psychiatric or learning disorder unrelated to pku * any condition that, in the view of the investigators, places subject at high risk of poor treatment compliance or of not completing the study * use of l-dopa, methotrexate, or other drugs that may inhibit folate metabolism

Keywords: pku kuvan bh4 tetrahydrobiopterin
genitourinary symptoms with levonorgestrel releasing intrauterine systems

Conditions: Lower Urinary Tract Symptoms

Summary: the main purpose of the study was to evaluate the efficacy of levonorgestrel releasing intrauterine devices (lnr-iud) on genitourinary symptoms in patients with abnormal uterine bleeding. the patients were asked urogenital distress inventory (udi) (which includes; irritative symptoms, stress symptoms, obstructive discomfort) and incontinence impact questionnaire (iiq) (which includes; physical activity, travel, social/relationships, emotional health)questionnaires in the day of application lnr-iud and six months later this procedure. statistical analyse will be performed to evaluate the changes in this time period.


Eligibility criteria:
inclusion criteria: * women using levonorgestrel releasing intrauterine device for the treatment of menorrhagia or adenomyosis exclusion criteria: * none
percutaneous electrolysis and vacuum myofascial therapy devicetrial.

Conditions: Epicondylitis

Summary: the concept of epicondylitis refers to the manifestation of pain in the area of insertion of the epicondile muscles, and that it is accompanied by limitation functional. a tendinopathy is characterized as a process of degeneration, with fibroblast proliferation and disorganization of the fibers of collagen. this tendon pathology especially affects the epicondyle extensors and especially the first and second radial and short extensor carpal.

experimental group will be treated therapeutic percutaneous electrolysis and vacuum myofascial therapy device once week for four weeks associated with eccentric exercises devices at home and the control group will be included 10 sessions of ultrasound pulsatil therapy (us) and massage associated with eccentric exercises devices at home.

Eligibility criteria:
inclusion criteria: * patients of both sexes, aged between 18 and 60 years, in an active state of pain and with a diagnosis of one month of evolution. exclusion criteria: * patients who are pregnant, have pacemakers and those surgically operated patients who have been treated with electrolysis and vacuum myofascial therapy device a month earlier

Keywords: tendinopathy electrolysis exercise dry needing massage cupping vacuum negative pressure
the epidemiology, management and comorbidities in alopecia areata in czech republic

Conditions: Alopecia Areata; Alopecia Totalis; Alopecia Universalis; Alopecia Areata (& Ophiasis); Alopecia Barbae; Alopecia Diffuse; Autoimmune Diseases; Autoimmune Hyperthyroidism; Autoimmune Hypothyroidism; Diabetes Mellitus, Type 1; Ulcerative Colitis; Inflammatory Bowel Diseases; Crohn Disease; Rheumatoid Arthritis; Down Syndrome; Atopic Dermatitis; Atopic Asthma; Atopic Rhinitis; Vitiligo; Psoriasis; Ankylosing Spondylitis; Multiple Sclerosis; Lupus Erythematosus; COVID-19 Pandemic; Vaccine Reaction; Infections; Anemia, Pernicious

Summary: the study series consists of three studies with the aim to assess the incidence, prevalence, risk factors, comorbidities and management of patients with alopecia areata in czech republic based on the patients and registry of a dermatology clinic of a metropolitan hospital.

the first study will aim to identify the incidence and prevalence of alopecia areata in the dermatology clinic of a metropolitan teaching hospital between 1/1/2011 and 31/12/2020 the second study will assess (1) the epidemiology of autoimmune and atopic diseases in patients with alopecia areata, (2) the presence of possible risk factors responsible for the onset/relapse/exacerbation of alopecia areata, (3) the levels of vitamin d and various autoantibodies,particularly thyroid autoantibodies and (4) the variety, duration, efficacy and safety profile of treatment modalities used in our hospital for the management of alopecia areata from 15/10/2021 to 14/10/2022. the third study will monitor the monthly oscillations of vitamin d and thyroid-autoantibodies of patients with new-onset/relasping or exacerbating alopecia areata for six months, between 15/10/2021-14/10/2022 in order to observe if changes in levels of vitamin d and thyroid-antiantibodies are associated with severity and prognosis (worsening or improvement) of alopecia areata

Eligibility criteria:
inclusion criteria: * all patients visiting our clinic with a dermatologic condition between 1/1/2011-31/12/2020 * for the second study, only patients with histologic/dermatoscopic diagnosis of new-onset/relapsing/peristent-untreated alopecia areata, presenting to our clinic between 15/10/2021-14/10/2022 are included. exclusion criteria: * for the second study patients with other alopecias, patients denying data sharing despite signing the informed concent and presenting outside the study period are excluded. * for the third study, patients with other types of alopecia, as well as those who signed the informed consent but refused to share their data or undergo blood tests at our hospital, and those who did not visit our outpatient department at least once a month for the required duration, were excluded.
marginal bone loss in single implant restaurations with different methods

Conditions: Bone Loss

Summary: the investigator is going to measure the marginal bone loss in single implant restaurations with three different methods: direct overcast, milled cad/cam direct to implant restauration and milled cad/cam implant restauration using an transepithelial pilar

the investigator has chosen a statistically significant sample (compared with other similar studies) to analize the bone marginal loss in different types of restauration with single dental implants

Eligibility criteria:
inclusion criteria: * patients with single implants restaurations treated in leon university exclusion criteria: * pregnant * mayor heath issues * patients who do not agree to participate
lap-assisted vs. us-guided visualization of tap blocks

Conditions: Pain, Postoperative

Summary: peripheral nerve blocks have been effective in decreasing post-operative pain as well as the use of narcotics for numerous years. typically, these blocks are placed by anesthesiologist via ultrasound. in more recent years, surgeons have been placing nerve blocks laparoscopically. since there are few studies that looks compare the two techniques we aim to perform a randomized control trial to demonstrate if a laparoscopic placed nerve block is as efficient and accurate as an ultrasound placed block.

ultrasound-guided peripheral nerve blocks like the transversus abdominis plane (tap) block are useful for post-operative pain control and reducing opioid analgesics.(1-3) a recent meta-analysis of tap blocks in adults demonstrated a reduction in post-operative opioid requirements, and improved pain scores.(2) within the pediatric population, numerous other studies have confirmed the benefit of tap blocks and their ability to lower pain scores, reduce opioid use and opioid-related side effects post-operatively.(4) while there have been many prospective randomized trials for ultrasound-guided tap blocks (5-7), there has been limited evaluation of surgically-placed tap blocks (8). there has been no published data evaluating or comparing surgically placed tap blocks in pediatric patients undergoing laparoscopic procedures. placed tap blocks in pediatrics have not been examined in patients undergoing laparoscopic procedures.(4) our pilot study was designed as a proof of concept, to demonstrate that ultrasound images could be used to verify the distribution of local anesthetic after a laparoscopically-assisted tap block. the aim of this study is to continue using ultrasound to verify the location of laparoscopic-assisted tap blocks, and compare the post-operative outcomes (pain scores, opioid use, etc.) to those who receive ultrasound-guided tap blocks. we plan to do this in a prospective, randomized and semi-blinded fashion. we hypothesize that (1) we will be able to accurately describe the location of the tap block placed by both methods in more than 90% of cases; (2) laparoscopic-assisted tap blocks will be as effective as ultrasound-guided tap blocks in terms of managing/reducing post-operative pain scores and reducing the amount and frequency of postoperative opioid analgesia.

Eligibility criteria:
inclusion criteria: * patients age 0-18 years who are undergoing laparoscopic surgery at lucille packard children's hospital * clinical indication for abdominal peripheral nerve block exclusion criteria: * conversion to open procedure * allergy to local anesthetic * multiple procedures planned with \>1 surgical specialty

Keywords: transversus abdominus plane nerve block tap block laparoscopic vs. ultrasound post-op pain
analyzes of hemorrhagic obstetric patients whose were used fibrinogen

Conditions: Hemorrhage

Summary: the files of hemorrhagic obstetric patients undergoing surgery and followed in the intensive care unit and using fibrinogen and blood products were included in the study between january 2015- september 2018 at the anesthesiology and reanimation clinic of sbu kanuni sultan süleyman training and research hospital. patients under 18 years of age were excluded from the study. in this study, ages, operation types, number of blood and products, the amount of fibrinogen, the results of the hemogram and bleeding parameters, the levels of fibrinogen, the duration of hospital stay and the intensive care unit were recorded.

bleeding is an important event that threatens the patient's life. too much blood and blood products can be used in massive bleeding. however, unwanted allergic reactions may occur in blood and blood product transfusions. fibrinogen is the first coagulation factor in coagulopathy. some studies have shown that when the fibrinogen level falls to \<150-200 mg / dl, the bleeding increases dramatically.

Eligibility criteria:
inclusion criteria: * obstetric patients, underwent surgery and followed in icu * used fibrinogen and blood products * over 18 years age exclusion criteria: * under 18 years age * obstetric patients, underwent surgery but not used fibrinogen and blood products

Keywords: hemorrhagic obstetric fibrinogen
study of de-114 ophthalmic solution in patients with allergic conjunctivitis

Conditions: Allergic Conjunctivitis

Summary: the purpose of the study is to demonstrate safety and efficacy of de-114 ophthalmic solution compared to its placebo and olopatadine hydrochloride 0.1% ophthalmic solution in patients with allergic conjunctivitis.


Eligibility criteria:
inclusion criteria: * provided signed, written informed consent. * has a positive result from an allergen-specific ige antibody test. * if a subject is a female of childbearing potential, she must utilize reliable contraceptive throughout the study, and must have a negative urine pregnancy test prior to enrollment into this study. exclusion criteria: * females who are pregnant, nursing or planning a pregnancy, or females of childbearing potential who are not using a reliable method of contraception. * presence of any abnormality or significant illness that could be expected to interfere with the study.
mafld-simplified definition as an optimized risk stratification tool for predicting metabolic outcomes

Conditions: Metabolic Associated Fatty Liver Disease

Summary: recently, a consensus was proposed by an international expert panel for the terminology changed from nafld to metabolic associated fatty liver disease (mafld). the comprehensive criteria shift to a "positive" diagnosis. it helps to increase patient awareness and understanding of fatty liver (fl), for who has high-risk metabolic dysfunction. however, a more simplified and easily applicable definition is needed. it will have an impact on clinical practice, especially in developing countries.

nonalcoholic fatty liver disease (nafld) is the most common cause of chronic liver diseases. it affects nearly 25% of the global population. recently, a consensus was proposed by an international expert panel for the terminology changed from nafld to metabolic associated fatty liver disease (mafld). the comprehensive criteria shift to a "positive" diagnosis. it helps to increase patient awareness and understanding of fatty liver (fl), for who has high-risk metabolic dysfunction. however, a more simplified and easily applicable definition is needed. it will have an impact on clinical practice, especially in developing countries. it may provide a better understanding of mafld, and optimize strategies for prevention of extrahepatic complications in clinical practice.

Eligibility criteria:
inclusion criteria: * diagnosed ad fatty liver by ultrasound exclusion criteria: * missing data on ultrasound, blood glucose, bmi and metabolic status.
behavioural and electrophysiological effects of rtms in functional neurological disorders

Conditions: Functional Neurological Disorder

Summary: the purpose of this study is to better understand functional neurological disorders (fnd) by measuring movement timing and brain activity in patients with fnd during deliberate movements and when expressing an 'intention' to move. this investigation will use non-invasive brain stimulation to investigate the role of the temporal-occipital-parietal junction in fnd.

this study seeks to improve our neurophysiological understanding of functional neurological disorders (fnd) by measuring movement timing and brain activity while individuals with fnd perform a simple pointing task. behavioural (timing of arm and finger movement) and electrophysiological (electroencephalography; eeg) measures will be collected both at rest and while participants perform a voluntary movement task designed to discriminate between brain events related to intention vs. overt action. furthermore, this study will investigate the ability of a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rtms) to alter brain activity in the temporal-occipital-parietal junction (tpj), a region known to be hypo-active in individuals with fnd. tasks and cortical recordings will be repeated following rtms to determine the effect of brain stimulation on behaviour and brain activity.

Eligibility criteria:
inclusion criteria: * confirmed diagnosis of functional neurological disorder with motor symptoms. exclusion criteria: * presence of another comorbid psychiatric disorder; * any contraindication for rtms (e.g., implanted metal devices; cardiac pacemaker or pacemaker wires; neurostimulators; implanted pumps, metal in the body \[rods, plates, screws, shrapnel, dentures, iud\] or metallic particles in the body, surgical clips in the head, previous neurosurgery, cochlear implants, prosthetic heart valves); * currently pregnant.
efficacy and safety of shenyankangfu tablets for primary glomerulonephritis

Conditions: Glomerulonephritis; Proteinuria

Summary: -evaluate the efficacy and safety of shenyankangfu tablets to control the proteinuria of patients with primary glomerulonephritis compare with losartan potassium.


Eligibility criteria:
inclusion * diagnosed with primary glomerulonephritis * aged from 18 to 70 years，male or female * blood pressure can be controlled ≤140/90mmhg * gfr≥45ml/min/1.73㎡ * 0.5g≤24 hours proteinuria≤3.0g * traditional chinese medicine syndrome conform qi-yin deficiency * obtain the agreement of patients or their guardians, and signed informed consent file exclusion criteria: * secondary nephropathy * take the glucocorticoid,immunosuppressants and tripterygium drug in the last 12 months * take other chinese patent medicine and decoction which can reduce proteinuria in the last 2 weeks * take renin-angiotensin system blockers in last 4 weeks * combined with severe primary disease of heart, brain, liver and hematopoietic system, or other serious diseases can affect patient's life * pregnant or lactating women * allergic predisposition or known to be allergic to the drug composition * blood presser \<90/60mmhg * with unilateral or bilateral renal artery stenosis * with mental disorders and poor compliance * be suspected or confirmed with alcohol, drug abuse history * be participating in another clinical study at the same period

Keywords: glomerulonephritis proteinuria shenyankangfu tablets losartan potassium efficacy safety
outcome of la versus ga for staged cea prior to cabg

Conditions: Carotid Artery Diseases; Coronary Artery Disease; Stroke

Summary: a retrospective analysis of all patients that underwent carotid endarterectomy (cea) for stenotic disease - diagnosed at pre-operative investigation - prior to cabg as staged operation within 6- months. the rate of postoperative stroke and complications was compared between cea performed under local anaesthetic (la) to those performed under general anaesthetic (ga).

the primary outcome was the rate of postoperative stroke in patients that had staged cea prior to cabg. this was defined as cea within a period of 4 weeks prior to cabg. we retrospectively looked at those patients that fulfilled the inclusion criteria and had cea performed either under la (group a) or under ga (group b). we measured the 30 days' postoperative stroke rate as the main outcome. we also looked at the rate of intraoperative stroke. additionally, we assessed the rate for developing nerve injuries and/or hematoma postoperatively. finally, we examined the risk for developing postoperative stroke in patients with bilateral significant carotid artery disease that underwent surgery in one side.

Eligibility criteria:
inclusion criteria: - all patients that had carotid endarterectomy performed in staged fashion within 6 months before a cabg operation. exclusion criteria: * patients diagnosed with symptomatic carotid disease