Kornimate/medical-research-clean huggingface dataset:
botox versus oxybutynin as first line treatment for the poorly compliant pediatric neurogenic bladder

Conditions: Neurogenic Bladder

Summary: the purpose of this study is to investigate the use of botulinum toxin a as primary therapy for children with neurogenic bladder due to spina bifida and compare results with standard oral oxybutynin therapy. this study hopes to demonstrate that botulinum toxin a can maintain or improve bladder storage function without side effects associated with oxybutynin use.


Eligibility criteria:
inclusion criteria: * diagnosis of spina bifida and neurogenic bladder * performing clean intermittent catheterization (cic) * taking 0.3-0.4 mg/kg/day of oxybutynin for a poorly compliant bladder * has not had previous bladder surgery * has had a urodynamic or videourodynamic study done within the last 6 months * upper motor neuron (umn) type bladder demonstrated on last urodynamic study * urodynamic study (uds) showing either detrusor leak point pressure \>40cm h2o; 30cm below capacity \<60% of total bladder capacity, 20 cm capacity \<70% of bladder capacity * able and willing to complete cic diaries and quality of life questionnaires * consent and assent given to participate in trial exclusion criteria: * history of lung disease, recurrent aspiration or severe neurological impairment which may increase risk of botox toxicity or anesthesia * positive urine culture * known allergy to botox

Keywords: pediatric
swiss national registry of grown up congenital heart disease patients

Conditions: Congenital Heart Disease; Congenital Heart Defect

Summary: due to successes in the last decades in pediatric heart surgery and cardiology, 90-95% of the children with congenital heart disease reach adult age.this results in an increasing number of adults or "grown-ups" with congenital heart disease (achd or guch patients) that require special health care organization and training programmes. long term complications of these guch patients and optimum treatment strategies are still poorly known. the aim of this registry is to collect quantitative and qualitative data regarding guch patients treated in specialised centres in switzerland.

the swiss guch registry will capture epidemiologic data, diagnosis, type of earlier treatment / intervention and cardiac complications. following each visit, the cardiac complications will be captured as well as the mortality. every guch patient coming for a visit in one of the specialized organisation participating to the registry will be asked to participate. after signing the informed consent form, the patient data will be coded and captured in a web-based data base (secutrial®). pooling the data from the different centres will enable a nation wide register to be established. more robust data on the size and composition of the guch population will be obtained. also long term prognosis of specific patient group will be derived.

Eligibility criteria:
inclusion criteria: adult (above 18 years of age) with congenital heart disease, treated in one of the swiss centre with specialized organisation for guch patients. signed informed consent. patients with trisomy 21: the parents or legal guardian will have to give the consent. exclusion criteria: none

Keywords: adult registry grown-up congenital heart disease
validation of questionnaire and assessment of patient satisfaction for budesonide/formoterol fix combination dry powder inhalers (dpi) in chronic obstructive pulmonary disease (copd)

Conditions: Chronic Obstructive Pulmonary Disease (COPD)

Summary: the aim of this study is to describe patient preferences on budesonide/formoterol fix dose combination for the treatment of their copd, and to find those factors more strongly associated to a better attitude to medication.

validation of questionnaire and assessment of patient satisfaction for budesonide/formoterol fix combination dpi in copd

Eligibility criteria:
inclusion criteria: * provision of subject informed consent and to be an outpatient * clinical diagnosis of copd according to icd-10 classification, females and males, aged ≥ 40 years * to be prescribed a fixed dose combination of inhaled budesonide/formoterol fix combination at least 3 months before the study start exclusion criteria: * pregnancy for women * use of inhaled medication via a metered dose inhaler (pmdi) * currently participating in randomized clinical trials and being included in this study once

Keywords: copd, patient satisfaction, fix combination, nis turkey, turbuhaler, fsi-10
brain aging project--kansas university

Conditions: Alzheimer's Disease

Summary: the purpose of this study is to determine the effects of exercise and cardiorespiratory fitness on age-related brain changes.

the mission of the ku brain aging project is to promote healthy brain aging. how the brain changes with age is not well-characterized and even less is known about the factors influencing the rate of brain aging. thus, we are using mri scans to examine the structure of the brain in relation to important lifestyle factors. this will allow us to better understand the processes influencing the brain as it ages. in turn, this will help identify specific ways to promote healthy brain aging and, perhaps, prevent the onset of alzheimer's disease. participants complete 4 visits over several months. the first visit entails a clinical evaluation and memory testing involving the use of paper and pencil testing. the second visit is an mri brain scan which lasts approximately one hour. the third visit involves drawing blood for laboratory testing and blood banking for future lab studies, lasting roughly 4 hours. the glucose tolerance test is administered. the fourth and final visit is an assessment of the participant's metabolism and exercise testing. this visit lasts approximately two hours.

Eligibility criteria:
inclusion criteria: * age 65 years or older * healthy male or female * normal control volunteers and early alzheimer's disease patients * clinical dementia rating of 0, 0.5, or 1.0 * on stable doses of medications exclusion criteria: * unstable angina * schizophrenia * clinical signs of depression; major depression; mental health disorder; nervous system disorder * significant visual/auditory impairment * significant system illness; cancer * pacemaker/metal * thyroid problems * kidney dialysis * organ transplant * alcoholism * heart surgery * insulin

Keywords: cognitive decline dementia neuroimaging
psychosocial outcomes and transition readiness in uveitis

Conditions: Uveitis

Summary: it is widely acknowledged that the transition from paediatric to adult health services should be a multidimensional and multidisciplinary process that addresses the medical, psychosocial, and educational needs of adolescents and young adults (aya). despite this, there is currently a scarcity of research examining the relationships between psychosocial factors (e.g., anxiety, social support) and transition readiness in aya with uveitis. this study therefore aims to examine the relationships between psychosocial factors and transition readiness in pre-transfer adolescents and post-transfer young adults aged 10-25 years diagnosed with jia at a single centre. in total, 25 adolescents aged 10-16 years, together with a parent/guardian, will participate at sheffield children's hospital and 10 young adults aged 16-25 years will participate at sheffield teaching hospitals. participants completed a battery of self-report questionnaire measuring psychosocial factors (anxiety/depression, social support, family functioning, health-related quality of life) and transition readiness (transition knowledge and skills, self-efficacy). uveitis disease severity was also measured during clinic appointments. a subset of participants will also be asked to take part in a focus group. this study received full ethical approval, and all participants will give their written informed assent or consent before taking part.


Eligibility criteria:
inclusion criteria: * diagnosis of uveitis * uveitis managed by either sheffield children's nhs foundation trust or sheffield teaching hospitals nhs foundation trust * fluent in english exclusion criteria: * no diagnosis of uveitis * uveitis not managed by either sheffield children's nhs foundation trust or sheffield teaching hospitals nhs foundation trust * not fluent in english
zero to five automated oscillometric office blood pressure (aobp) measurement

Conditions: Hypertension; Cardiovascular Diseases

Summary: the hypertension canada clinical practice guidelines for blood pressure measurement using aobp recommend against any wait time prior to commencing the measurement. the recent aha guidelines however call for a 5-minute rest first. in uncontrolled hypertension, aobp is typically higher than the daytime readings from ambulatory blood pressure monitoring (abpm), but this is not the case for patients with controlled hypertension.

objective: does a 5 minute rest or no rest before measurement using aobp provide the most accurate reading in patients with controlled and uncontrolled hypertension, and in patients with white coat hypertension compared to daytime abpm? implications: through this study, we hope to: (i) advance the understanding of the role of aobp in measuring blood pressure. (ii) determine whether a 5-minute rest, or no rest at all is needed prior to aobp measurement. (iii) assess the relationship of aobp to daytime abpm for patient with controlled and uncontrolled hypertension and in patients with white coat hypertension.

Eligibility criteria:
inclusion criteria: * age 18 years or older * referred for abpm * written informed consent exclusion criteria: * unable to perform aobp or abpm for some reason
polypectomy in patients taking dual antiplatelet agents

Conditions: Colonic Polyps

Summary: current guidelines recommend discontinuation of antiplatelets (i.e clopidogrel) for 7 days in patients taking dat (dual antiplatelet therapy) before colonoscopy and polypectomy. the purpose of this study was to examine if a) discontinuation of these drugs reduces bleeding risks during polypectomy and if b) discontinuation of these drugs increases the occurence of thromboembolic events.

patients taking dual antiplatelets (dat) and who visited for colonoscopy were eligible for enrollment in this study. on enrollment, patients were randomized to two groups. one group continued dat and the other group discontinued antiplatelets (i.e. clopidogrel, ticagrelor, prasugrel) for 7 days before colonoscopy. if polyps (≤1 cm) were observed during colonoscopy, they were removed by cold snare polypectomy. the primary aim was to compared the delayed bleeding rates of the two groups.

Eligibility criteria:
inclusion criteria: * patients over the age of 20 years undergoing routine colonoscopy * patients who are taking dat (dual antiplatelet therapy) exclusion criteria: * patients not abiding to the study protocol * history of inflammatory bowel disease * severe comorbidities * american society of anesthesiology class iii or more * pregnancy

Keywords: colonoscopy
effect of glp-1 receptor agonism after sleeve gastrectomy

Conditions: Obesity

Summary: observational studies suggest that bariatric surgery is the most effective intervention for weight loss. comparative effectiveness of roux-en-y gastric bypass (rygb) and sleeve gastrectomy (sg) demonstrate that rygb is significantly superior to sg in terms of weight loss and glycemic control. both rygb and sg increase glp-1 concentrations which directly affect b-cell function. data has shown that the postprandial rise in glp-1 might affect feeding behavior after rygb and to a lesser extent sg, where the increase in glp-1 is less marked. in this study the investigators propose to randomize subjects undergoing sg to receive either placebo or liraglutide, a glp-1 receptor agonist, to compare weight loss and cv risk factors.

a total of 75, non diabetic adults, scheduled for bariatric surgery at mayo clinic rochester, will be enrolled. of these, 25 will be scheduled for roux-en-y gastric bypass surgery (rygb), while the remainder (50) will be scheduled for sleeve gastrectomy (sg). the study team will play no role in assignment of the surgical procedure. following surgery, at month 3, subjects undergoing sg will be randomized to either saxenda or placebo, subcutaneously once daily. subjects randomized to saxenda or placebo will take for the duration of the study (33 months). follow up study visits for all subjects will be timed to coincide with the standard clinical follow up visits at months 3, 6, 9, 12, 18, 24, 30 and 36.

Eligibility criteria:
inclusion criteria: 1. age 20-65 years of age 2. seen at mayo clinic nutrition clinic and have received authorization for bariatric surgery. 3. no active physical illness which will interfere with mobility or weight loss after bariatric surgery. 4. females who are sexually active and able to become pregnant must agree to use birth control for duration of study if randomized to saxenda/placebo. exclusion criteria: 1. prior use of glucose lowering medication in the 3 months prior to screening. 2. a fasting glucose ≥ 126mg/dl or an hba1c ≥ 6.5% will be taken as evidence of type 2 diabetes and therefore patients will be deemed ineligible for participation. 3. prior abdominal surgery other than cholecystectomy, appendectomy or hysterectomy. 4. pregnancy or active consideration of pregnancy during the period of study. subjects will be discontinued if they become pregnant during the study. 5. hypersensitivity to liraglutide or any product components. 6. personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2. 7. prior history of pancreatitis, cholelithiasis or cholecystitis. 8. concurrent use of insulin or any other glp-1 receptor agonist. 9. active, severe psychiatric disease

Keywords: weight loss bariatric surgery
the effect of laparoscopic splenectomy on liver reserve function for cirrhosis patients

Conditions: Cirrhosis, Liver; Splenectomy; Status

Summary: in this study, the investigators compared the improvement of liver reserve function related indicators in patients with liver cirrhosis after laparoscopic splenectomy. to determine whether surgical treatment can help enhance postoperative liver reserve function and improve patient prognosis.

the patients were enrolled according to the research criteria, and collected the general basic information of the patients. after the preoperative preparation was perfected, the same surgical team performed laparoscopic splenectomy, and the same nursing team performed the nursing after the operation. then, patients received a unified treatment plan after surgery, including medication, other treatments and follow-up. during the treatment, the liver reserve function related indicators of the patients were monitored before surgery, 3, 6, 12 and 24 months after surgery, including tbil, dbil, alb, alt, inr, pt, child-pugh, ascites, prealbumin, icg-k, icg-r 15 and icg-t/2.

Eligibility criteria:
inclusion criteria: * a clinical, radiological or histologic diagnosis of cirrhosis of any etiology * splenomegaly with secondary hypersplenism, platelet count \< 50\*10\^9/l * informed consent to participate in the study exclusion criteria: * hepatocellular carcinoma or any other malignancy, * child-pugh grade c * recent peptic ulcer disease * history of hemorrhagic stroke * pregnancy. * uncontrolled hypertension * bleeding portal hypertension * human immunodeficiency virus (hiv) infection

Keywords: cirrhosis splenectomy liver reserve function laparoscopy
teachers and parents as partners during middle school

Conditions: Behavior Problem

Summary: there are two aims of this study (a) to examine the effect of teachers and parents as partners on student, parent, and teacher outcomes in middle school and (b) identify barriers and facilitators to implementing teachers and parents as partners in middle school for students with behavior concerns.

teachers and parents as partners will occur in a series of stages comprised of approximately four structured meetings over approximately 8 weeks. a teachers and parents as partners consultant will meet together with a student's parent(s), teachers, other school personnel (as appropriate), and the student (as appropriate). the teachers and parents as partners team will collaboratively address behavior problem solving objectives. specific cbc objectives include: identifying strengths and specific behaviors of concern, specifying alternative prosocial behaviors, creating measurable behavior goals, co-constructing behavior intervention/support plans to address the target concerns, creating sustainable conditions to support plan implementation at home and school, and evaluating the plan to assess progress toward goals. treatment integrity in multiple dimensions (e.g., engagement, dosage, adherence) will be assessed at the two tiers of implementation (i.e., teachers and parents as partners procedural integrity and behavior support plan implementation) to determine the extent to which procedures are implemented as designed. during each structured meeting, teachers and parents as partners consultants will inquire with parents, teachers, other school personnel, and students about barriers and facilitators to implementation.

Eligibility criteria:
inclusion criteria: * students will be eligible if they have scores in the "elevated" or "extremely elevated" risk categories on the parent and teacher version of the behavior assessment scale for children (basc) 3 behavioral and emotional screening system (bess). parents, and primary teachers and school staff associated with an eligible student will be included. exclusion criteria: * students who do not meet the inclusion criteria will be excluded from participation, which includes their parent(s), teachers, and other school personnel. students also may not be eligible if they have mental health concerns that may not be appropriate for teachers and parents as partners or a research project (e.g., some internalizing problems, students who pose an risk of harming themselves).
the psychosocial outcomes in caregivers of children with food allergy

Conditions: Food Allergy in Children; Caregiver Burnout; Psychosocial Problem; Family Research

Summary: the purpose of this study is to evaluate use of a mobile application (also commonly referred to as an app) designed to support caregivers of children with newly diagnosed food allergy. this study has 2 phases. in phase 1, the researchers obtained feedback regarding use of mobile apps from caregivers who have been managing their child's food allergy for one year or more. the researchers then used this feedback to build a mobile app for caregivers of children with newly diagnosed food allergy. in phase 2, the researchers will evaluate the mobile app during a 4-week evaluation period with a group of caregivers of children newly diagnosed with food allergy. the data obtained from this study will hopefully benefit caregivers of children with newly diagnosed food allergy.


Eligibility criteria:
inclusion criteria: * caregiver of child less than or equal to 18 years of age who are newly diagnosed (less than or equal to 90 days from diagnosis) with food allergy(ies). exclusion criteria: * caregiver with cognitive impairment/deficit and/or observed lack of understanding during the informed consent process
treatment of exercise-induced laryngomalacia in elite athletes

Conditions: Exercise-induced Laryngomalacia

Summary: treatment of exercise-induced laryngomalacia (an obstruction of larynx during physical activity) in elite athletes using two different treatments. the study is randomized with control groups.


Eligibility criteria:
inclusion criteria: * laryngoscopically verified eil, * elite athlete for a minimum of 1 year and continuing for a minimum 6 months after start of treatment exclusion criteria: * has to be able to run on treadmill

Keywords: eil
safety and performance assessment of the symbol range of medical devices in patients underlying total hip arthroplasty

Conditions: Degenerative Hip Joint Disease; Post-traumatic Osteoarthritis; Hip Arthritis; Femoral Neck Fractures; Avascular Necrosis of the Femoral Head; Failure of Prosthetic Joint Implant

Summary: the purpose of this post-market clinical follow up study is to assess the safety and effectiveness of the symbol range of medical devices. the study will evaluate the outcome of total hip arthroplasty using medical devices from symbol range over a period of 10 years.


Eligibility criteria:
inclusion criteria: * patient age \> 18 years at implantation. * patient who will undergo, during the study's period of inclusion, a total hip arthroplasty (primary or revision) with at least one symbol medical device (dedienne santé). * patient informed of his/her participation and willing to participate in the study. * patient able to read, write and understand french. exclusion criteria: * patient deprived of freedom, under guardianship/curatorship or placed under judicial protection * patient unable to follow study procedures. * patient who has already been included in the study for a total hip arthroplasty (primary or revision) with at least one symbol medical device.
a validation study to evaluate the performance of caption health lung guidance and interpretation

Conditions: Shortness of Breath

Summary: the purpose of this study is to assess the efficacy of caption lungai.

after being informed about the study, all patients giving written informed consent will undergo two 8-zone protocol lung ultrasound exams. one exam will be conducted by an expert lung ultrasound user without caption lungai and one exam conducted by a (non-expert) healthcare provider who is trained on caption lungai and will use caption lungai to capture images.

Eligibility criteria:
inclusion criteria: * patients over the age of 18 * patients presenting to the hospital or outpatient setting with shortness of breath and suspected b-lines. exclusion criteria: * patients in extremis/in whom a research lung ultrasound would not normally be performed due to other priorities

Keywords: lung ultrasound b-lines pocus by non-expert user