Kornimate/medical-research-clean huggingface dataset:
hypersensitivity pneumonitis of domestic origin

Conditions: Sensitisation; Mold or Dust Allergy; Respiratory Disease

Summary: exposure to molds in dwellings is a public health problem. diagnosis of hypersensitivity pneumonitis due to mold exposure at home (domestic hp) are increasing. to perform the serodiagnosis of domestic hp a cohort constitued of proven cases and exposed healthy controls are needed. the home hp study aimed at obtaining a cohort of proven cases and exposed controls in order to be able to improve the serodiagnosis of domestic hp.

hypersensitivy pneumonitis (hp) are chronic respiratory diseases due to frequent exposure to high quantities of allergens (molds, bacteria, mycobacteria, avian proteins). in case of domestic hp, patients are exposed at home to molds due to flooding or poor ventilation. the diagnosis of domestic hp includes detection of igg towards molds. a prior study in 2005 allowed the determination of frequent allergenic molds isolated in homes in bourgogne franche comte (study on 110 dwellings). however, no real cohort of proven cases versus controls is available. so, we are lacking validated thresholds. the home hp study is a prospective study that will include several centers of pneumology on france territory. the fungal contamination of dwellings occupied by patients suffering of interstitial disease (dip), including suspicion of domestic hp, will be analyzed. the most frequently isolated molds will be then produced as antigens and will be tested in order to assess the sensitization of the included patients. the data of imagery, balf cytology will allow to determine if patients are diagnosed with domestic hp or not. we will then obtain 2 groups of patients 1-proven domestic hp and 2-non domestic hp . comparing the number of immunization arcs between the 2 groups will then be possible to validate appropriate thresholds for the serodiagnosis of domestic hp. domestic hp are rare diseases, so a high number of inclusions will be needed to obatin in 2 years about 25-30 proven cases. the home hp study is important to improve the serodiagnosis of domestic hp.

Eligibility criteria:
inclusion criteria: * exposure to mold at home * given consent * suspicion of doemstic hp * clinical signs of interstial pneumopathy exclusion criteria: * immunocompromised patients * prior diagnosis of another hp form (avian, farm, bath tub etc..) * exposure to avian proteins

Keywords: hypersensitivity pneumonitis molds dwellings thresholds
intravenous iron in patients with heart failure and reduced ejection fraction (hfref) plus iron deficiency

Conditions: Heart Failure, Systolic; Iron Deficiency

Summary: effects of ferric carboxymaltose single hd (1000 mg) infusion upon fgf23 in patients with isolated hfref compared to patients with hfref+ckd (all pts with iron deficiency). this study aims at identification of the optimal target population for a follow-up ("main") study.

iron deficiency is highly prevalent in patients with hfref and intravenous high-dose (hd) iron application has significantly improved clinically meaningful endpoints in such patients. the best evidence is existent for ferric carboxymaltose. intravenous hd iron may influence phosphate metabolism via increases in levels of intact fgf23 and hence induce prolonged hypophosphatemia. such increases in fgf23 may particularly occur depending on the type of iron carrier. fgf23 is a significant risk factor for mortality and morbidity in patients with hfref and other cardiac populations at risk and may directly cause left ventricular hypertrophy and dysfunction. hence, the application of i.v. hd iron may have potentially beneficial effects on cardiac function but harmful effects via fgf23-induction and hypophosphatemia at the same time. however, fgf23 metabolism has not yet been evaluated in hfref patients following i.v. hd iron. fgf23 is elevated in patients with chronic kidney disease. patients with hfref + ckd = chronic cardio-renal syndrome are at particular risk regarding elevated morbidity and mortality. the effects of intravenous hd iron upon phosphate and fgf23 metabolism in patients with hfref + ckd is unknown and effects in this setting may be different compared to effects in patients without pre-existing fgf23 stimulation.

Eligibility criteria:
inclusion criteria: * written informed consent. * age \> 18 yrs * symptomatic hfref (lv ejection fraction \< 45%) with optimal medical therapy (omt) for at least 2 months * iron deficiency as indicated by by ferritin \<100 ng/ml or ferritin 100-299 ng/ml when transferrin saturation (tsat) \<20% and hb value \< 13mg/dl (women) and \<14 mg/dl (men) * group a: stable ckd for at least 2 months, defined by estimated glomerular filtration rate (egfr) (ckd-epi formula) as 15-60 ml/min/1,73 m3 (ckd iii, iv, v-non d) * group b: patients with stable egfr \> 60 ml/min/1,73 m3 exclusion criteria: * known hypersensitivity to ferric carboxymaltose or any constituents of the formulation, * plasma phosphate \< 2.5 mg/dl at screening, * renal replacement therapy/transplantation, * pregnancy or lactation * iron substitution therapy or erythropoetin (epo) therapy within 6 weeks before * participation in another clinical trial with an experimental drug * expectation of missing compliance * alcohol or drug abuse * the subject is mentally or legally incapacitated * patients who are in a relationship of dependence or in a working relationship to the sponsor, the investigator or his representative

Keywords: iron deficiency hfref fgf23 ferric carboxymaltose
diagnosis of atrial fibrillation in postoperative thoracic surgery using a smartwatch

Conditions: Postoperative Atrial Fibrillation; Thoracic Surgery; Smartwatches; Rhythm Monitoring; Cardiovascular Prognosis; Asymptomatic Atrial Fibrillation; Randomized Trial

Summary: postoperative atrial fibrillation (poaf) occurs in approximately 20% of patients following thoracic surgery. early diagnosis is essential to prevent complications such as heart failure, stroke, myocardial infarction, and increased mortality. smartwatches equipped with single-lead ecg capabilities and algorithms to detect asymptomatic atrial fibrillation (af) offer a potential solution. this study aims to evaluate the effectiveness of smartwatches in detecting poaf compared to standard care.


Eligibility criteria:
inclusion criteria: * adults (\>18 years old). * patients undergoing major thoracic surgery with one-lung ventilation within the past 48 hours. * scheduled pneumonectomy or lobectomy. * admission to a conventional surgical unit postoperatively. * ability to perform single-lead ecg using a smartwatch. * coverage under a social security system. * signed informed consent exclusion criteria: * history of atrial fibrillation. * requirement for telemetry for av block or tachyarrhythmias (\>140 bpm). * dependency on a pacemaker. * participation in another interventional clinical trial affecting poaf incidence. * mediastinal, pleural, or chest wall surgery. * reoperations or surgeries performed more than 48 hours prior. * pregnant women. * patients under guardians or similar legal protection.

Keywords: postoperative atrial fibrillation thoracic surgery smartwatches rhythm monitoring cardiovascular prognosis asymptomatic atrial fibrillation randomized trial
efficacy and safety of coblopasvir hydrochloride capsules combined with sofosbuvir tablets for the treatment of chronic hcv infection: a prospective, multi-center real-world study.

Conditions: Hepatitis C Infection

Summary: chronic hepatitis c is a long-lasting infectious disease caused by hepatitis c virus (hcv). according to statistics by the world health organization (who), the global hcv prevalence is estimated at 2.8%, equating to approximately 185 million. chronic hcv infection can lead to chronic inflammatory necrosis and fibrosis in the liver, and in some patients can develop into hepatic cirrhosis and even hepatocellular carcinoma (hcc), endangering the health and life of patients. the development of direct-acting antiviral agents (daas) since 2011 markedly improved antiviral efficacy and significantly shortened treatment cycle, making the drugs convenient for clinical use. small molecule daas exert target-specific effects on proteins involved in the hcv life cycle and have been included in the treatment guidelines by leading associations for the study of liver diseases worldwide. treatment regimen for hepatitis c - coblopasvir hydrochloride capsules combined with sofosbuvir tablets: coblopasvir hydrochloride capsule is an ns5a inhibitor that inhibits the replication and assembly of hcv, and sofosbuvir tablet is a ns5b polymerase inhibitor. the primary efficacy results (sustained virologic response 12 weeks post-treatment, svr12) were comparable between the phase ii and iii clinical studies: the overall svr12 in subjects was 97%. the svr12 after coblopasvir hydrochloride capsules combined with sofosbuvir tablets in genotype 3 infection with cirrhosis and genotype 3b infection with cirrhosis were superior to the results of sofosbuvir and velpatasvir tablets obtained in clinical studies in asia (83% vs. 72%; 67% vs. 50%). coblopasvir hydrochloride capsule and sofosbuvir tablet were approved for marketing by national medical products administration of china in feb. 2020 and mar. 2020, respectively. this study is designed to evaluate the safety and efficacy of coblopasvir hydrochloride capsules combined with sofosbuvir tablets in clinical practice after marketing.


Eligibility criteria:
inclusion criteria: 1. chronic hepatitis c infection 2. age 18 years and over 3. patients who treated with coblopasvir hydrochloride capsules/sofosbuvir tablets; exclusion criteria: 1. patients who are receiving other daas drugs at the same time; 2. subjects with poor compliance who are unable to complete treatment or follow-up.

Keywords: hepatitis c infection
electrical acupuncture and laser therapy for low back pain

Conditions: Chronic Low Back Pain

Summary: this is a treatment for low back pain using electrical stimulation and laser for 6 weeks.

the purpose of the study is to investigate the effects of electroacupuncture and laser therapy to treat chronic low back pain.

Eligibility criteria:
inclusion criteria: * low back pain for over 6 weeks exclusion criteria: * individuals with cancer * tuberculosis * pacemakers * pregnancy * osteoporosis * heart disease * kidney failure * thyroid disorders * diabetes * chronic disease * neurological diseases * skin or bleeding disorders * currently taking drugs or medications * a health history questionnaire will be used to screen subjects
efficacy and safety of finlândia hair lotion association on androgenetic alopecia

Conditions: Androgenetic Alopecia

Summary: the purpose of this study is to evaluate the efficacy of finlândia hair lotion association in the treatment of androgenetic alopecia.


Eligibility criteria:
inclusion criteria: * ability to confirm voluntary participation and agree to all trial purposes by signing and dating the informed consent forms; * men aged 18 years or over and less than or equal to 60 years with a diagnosis of androgenetic alopecia grades iiiv to iv in the modified norwood-hamilton classification, who have been using minoxidil 5% for at least 3 months and willing to maintain the same style, approximate length and hair color throughout the test. exclusion criteria: * known hypersensitivity to the formula components used during the clinical trial; * history of alcohol and/or substance abuse within 2 years; * participants with other concomitant dermatological diseases on the scalp, except for mild seborrhoea dermatitis; * participants with a history of surgical treatment for hair loss or shaved scalp; * participants who used shampoo or topical solution containing ketoconazole, tar, selenium, threonine or steroids in the last 2 weeks; * participants who used 5α reductase inhibitors, such as finasteride and dutasteride, in the last 12 months; * participants using testosterone replacement therapy (trt) or using testosterone-containing gel; * participants who used micro-infusion of medications on the skin (mmp), microneedling or intradermotherapy on the scalp in the last 3 months; * participants who have undergone radiation treatment for the scalp or chemotherapy in the past year; * participants with diseases that can affect hair growth; * participants with a current medical history of cancer and / or cancer treatment in the last 5 years;

Keywords: androgenetic alopecia
use of virtual reality to reduce anxiety and pain during repair of perineal laceration and episiotomy

Conditions: Perineum; Injury; Episiotomy Wound; Anxiety

Summary: virtual reality will be used to decrease anxiety and pain during suturing of episiotomy and perineal lacerations

perineal lacerations and episiotomies are common after vaginal birth. surgical repair of these conditions can cause discomfort and anxiety for the post-partum woman. the purpose of this research is to determine if the use of virtual reality (vr) during repair of a perineal laceration or episiotomy can decrease the anxiety level of the woman. other parameters that will be measured will be vital signs, time of procedure, and pain level. 84 eligible healthy women after spontaneous or instrumental vaginal birth will be enrolled. allocation will be randomized by previous sealed envelopes. 42 in the vr group and 42 in the control group. the 42 women in the vr group will have the device placed band in use before the onset of the procedure. anxiety level will be measured post-procedure by (stai) state inventory anxiety trait. pain will be measure by vas. assuming a significant anxiety level of 60% in women undergoing repair of a perineal laceration of episiotomy, in order to demonstrate a reduction to 30% in women using vr with a power of 80% and alpha of 0.05, 42 women will be needed in each group.

Eligibility criteria:
inclusion criteria: * post-partum vaginal delivery, spontaneous or instrumental * episiotomy or 1st or 2nd degree perineal tear * informed consent exclusion criteria: * cesarean delivery * 3rd or 4th degree perineal tear * no informed consent
a pilot study to explore the role of gut flora in multiple sclerosis

Conditions: Multiple Sclerosis; MS

Summary: this study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding multiple sclerosis.

the goal of this research study is to better understand how the genetic information in subject's microbiome correlates to the information provided in surveys and in medical records regarding multiple sclerosis.

Eligibility criteria:
inclusion criteria: 1. signed informed consent, demonstrating that the patient understands the procedures required for the study and the purpose of the study 2. male or female patients of any age (interest is given to children to compare with mothers). diagnosis of multiple sclerosis. exclusion criteria: 1. refusal to sign informed consent form 2. history of bariatric surgery, total colectomy with ileorectal anastomosis or proctocolectomy. 3. postoperative stoma, ostomy, or ileoanal pouch 4. participation in any experimental drug protocol within the past 12 weeks 5. treatment with total parenteral nutrition 6. any clinically significant evidence of disease that could interfere with the subject's ability to enter the trial 7. inability to adequately communicate with the investigator or their respective designee and/or comply with the requirements of the entire study
efficacy and safety study of iloperidone virus risperidone to treat schizophrenia

Conditions: Schizophrenia; Iloperidone; Efficacy

Summary: the purpose of this study is to determine whether iloperidone is effective in the treatment of schizophrenia.


Eligibility criteria:
inclusion criteria: * men or women ages 18-65 years old. * dsm-iv diagnosis of schizophrenia. * panss≥70. * of the 7 panss positive symptom subscale, at least two score ≥ 4 points. * written informed consent. exclusion criteria: * pregnant or nursing (lactating) women, or women who plan on conceiving during the course of the study. * clinically significant disease of the heart,kidneys,liver,hematonosis or endocrine system.

Keywords: schizophrenia iloperidone risperidone efficacy safety
total intravenous anesthesia for rigid bronchoscopy using remimazolam

Conditions: Respiratory Disease; Tracheal Stenosis; Endobronchial Mass

Summary: rigid bronchoscopy usually requires deep general anesthesia, but the duration of the procedure is relatively short. remimazolam, a recently developed anesthetics, showed faster recovery from anesthesia and stable hemodynamics compared to propofol, the most popular anesthetics. however, few studies have investigated the usefulness of remimazolam for rigid bronchoscopy. therefore, the investigators compared the usefulness of propofol and remimazolam in total intravenous anesthesia for rigid bronchoscopy.

rigid bronchoscopy usually requires deep general anesthesia, but the duration of the procedure is relatively short. therefore, anesthesiologists need anesthetics that simultaneously provide hemodynamical stability and faster recovery from anesthesia. remimazolam showed faster recovery from anesthesia and stable hemodynamic profiles compared to propofol, the most popular anesthetics during general anesthesia. however, few studies have investigated the usefulness of remimazolam during rigid bronchoscopy. in this randomized controlled trial, the investigators want to compare the recovery duration from anesthesia after a rigid bronchoscopy procedure between patients undergoing intravenous anesthesia using remimazolam and propofol.

Eligibility criteria:
inclusion criteria: * adult patients who undergoing rigid bronchoscopy under general anesthesia in samsung medical center, seoul, south korea * american society of anesthesiologists physical status i, ii, iii exclusion criteria: 1. patients who are contraindicated in benzodiazepine (e,g., allergy to the drug or have a history of hypersensitivity reactions) 2. drug or alcohol addiction 3. neuromuscular disease or mental illness 4. metabolic disease 5. emergency surgery 6. body mass index \>30 kg/m2 or \<18.5 kg/m2 7. patient's refusal 8. patients in shock or coma 9. patients contraindicated to remimazolam such as acute narrow-angle glaucoma, sleep apnea, severe or acute respiratory failure, galactose intolerance, lactase deficiency, glucose-galactose malabsorption, severe hypersensitivity to dextran 40.

Keywords: remimazolam rigid bronchoscopy
acute effects of foam rolling and proprioceptive neuromuscular facilitation stretching

Conditions: Athletes

Summary: the hamstring muscle is one of the key elements in rehabilitation programs and sports activities that enable the restoration of optimal muscle length. decreased flexibility in the hamstring muscle may disrupt the biomechanics of the waist and pelvis, leading to low back pain or musculoskeletal disorders. this study aims to investigate the acute effects of foam rolling and proprioceptive neuromuscular facilitation stretching during warm-up on muscle flexibility, strength, and pain threshold in amateur athletes. according to our research, there is no study in this field in the literature. h1: there is a difference between the acute effects of foam rolling exercise and pnf stretching exercise on muscle flexibility during warm-up in amateur athletes. h2: there is a difference between the effects of foam rolling and pnf stretching exercises used as warm-up exercises on muscle strength. h3: foam rolling and pnf stretching exercises applied to the hamstring muscle as a warm-up exercise make a difference in the pain threshold of the lumbar region and hamstring muscle.

stretching techniques used in athletes are frequently and widely used due to many effects such as changing range of motion, comfortable movement maintenance, and removal. there is no consensus in the literature on which of the static, dynamic, and proprioceptive neuromuscular facilitation stretching techniques is most effective, as opposed to the types of stretching for flexibility. there is no clear benefit of different stretching techniques to muscle performance. accordingly, in the literature, it is seen that proprioceptive neuromuscular facilitation stretching techniques show a greater increase in joint range of motion compared to other stretching techniques. recently, the use of foam rolling has become widely used in sports applications due to similar effects seen in stretching and the hypothesized presence of a curative effect on muscle performance. there is not enough research on the extent of foam rolling during warm-up exercises to increase flexibility and muscle strength. the hamstring muscle is one of the key elements in harmonious programs and sports activities that ensure the restoration of optimal muscle length. the emergence of the output in the hamstring muscle may disrupt the biomechanics of the waist and pelvis, causing low back pain or musculoskeletal disorders. this study aims to investigate the acute effects of foam rolling and proprioceptive neuromuscular facilitation stretching on muscle input, strength, and pain intensity during nutrition in amateur athletes.

Eligibility criteria:
inclusion criteria: * being between the ages of 18-30 * being an amateur athlete exclusion criteria: * hypermobility * history of hamstring injury in the last 6 months * diagnosed orthopedic problems * surgery in the lower extremity or spine * back pain * presence of systemic or neurological disorders

Keywords: muscle stretching exercises pain threshold range of motion, articular muscle strength