Kornimate/medical-research-clean huggingface dataset:
multisensory augmentation for post-stroke standing balance

Conditions: Stroke

Summary: many individuals who experience a stroke have problems with their balance. in part, these balance problems may be due to sensory issues. this study will test whether sensory augmentation has the potential to improve post-stroke balance. sensory augmentation is a method by which non-invasive vibration is used to enhance the sensory information available to users, which may make it easier to feel where they are and prevent losses of balance.

the objective of this study is to design a novel multisensory augmentation approach to improve the control of standing balance in people with chronic stroke. with sensory augmentation, artificial feedback provides the nervous system with information about the dynamic state of the body, which can be used to prevent losses of balance. this clinical trial will investigate whether multisensory augmentation produces sustained balance improvements when applied as a training device. these potential improvements will be assessed by comparing the results of clinical and biomechanical assessments before and after a 10-week balance training program, in which half of the participants will be randomly assigned sensory augmentation.

Eligibility criteria:
inclusion criteria: * experience of a stroke at least 6 months prior to participation * berg balance scale score less than 52 * ability to stand independently for at least 1 minute without wearing an afo or other brace that would preclude delivery of stimulation to the ankle or foot sole * provision of informed consent exclusion criteria: * resting blood pressure higher than 220/110 mm hg * history of unstable cardiac arrhythmias, hypertrophic cardiomyopathy, severe aortic stenosis, angina or dyspnea at rest or during activities of daily living * pre-existing neurological disorders or dementia * severe visual impairment * history of dvt or pulmonary embolism within 6 months * uncontrolled diabetes with recent weight loss, diabetic coma, or frequent insulin reactions

Keywords: stroke
validation of a multi-gene test for lung cancer risk

Conditions: Lung Cancer

Summary: the purpose of this study is to determine the validity of a multi-gene lung cancer risk test (lcrt). in the process, the investigators will establish a bank of nbec samples and corresponding blood samples from individuals demographically at increased risk for lung cancer.

because more than 160,000 individuals die of lung cancer/year in the united states alone, it is important to use the best possible methods to determine whether increased surveillance of individuals at highest risk for lung cancer will result in reduced lung cancer mortality. the lung cancer risk test (lcrt) proposed for evaluation promises to accurately identify the 10-15% of the population that is most susceptible to lung cancer based on genetic predisposition. more than 90 million individuals in the united states alone are demographically at high risk for lung cancer and potential candidates for increased surveillance.

Eligibility criteria:
inclusion criteria: * 20 or more pack year smoking history * clinical need for diagnostic bronchoscopy or consent to study driven bronchoscopy exclusion criteria: * lung cancer within 3 months after the date of enrollment

Keywords: lung cancer
electrical stimulation for the treatment of chronic post-stroke shoulder pain using the smartpatch system

Conditions: Post-stroke Shoulder Pain; Hemiplegic Shoulder Pain

Summary: the purpose of this study is to determine if electrical stimulation (small levels of electricity) reduces post-stroke shoulder pain. this study involves a device called the smartpatch system. the smartpatch system delivers mild electrical stimulation to the muscles in the shoulder. the smartpatch system includes a small wire (called a "lead") that is placed through the skin into the muscle of the shoulder. it also includes a device worn on the body that delivers stimulation (called the smartpatch stimulator).


Eligibility criteria:
key inclusion criteria: * at least 21 years of age * post-stroke shoulder pain * at least 6 months after stroke that caused shoulder pain key exclusion criteria: * use of habit-forming (narcotic) medications * bleeding disorder * history of recurrent skin infections * parkinson's disease, spinal cord injury, traumatic brain injury, multiple sclerosis, or complex regional pain syndrome * heart arrhythmia or artificial heart valves * uncontrolled seizures * implanted electronic device * pregnant

Keywords: electrical stimulation neurostimulation neuromodulation post-stroke shoulder pain hemiplegic shoulder pain
diacutaneous fibrolysis on carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome

Summary: diacutaneous fibrolysis is a manual method of treatment, addressed to mechanical pain of the neuromusculoskeletal system. in the clinical practice a favorable effect is observed in patients with carpal tunnel syndrome, but there is no published studies evaluating the results os this technique. the objective of this trial is to evaluate if diacutaneous fibrolysis is more effective in symptoms, function, grip, mechanosensitivity and neural conduction velocity compared to a placebo. for this purpose the investigators conduct a randomized controlled trial double-blind (patient and examiner). the investigators included patients diagnosed of carpal tunnel syndrome (low to moderate intensity) with a neurophysiological test. patients included are randomized into 2 groups one receive diacutaneous fibrolysis and the other placebo. both groups receive 5 treatment sessions. the variables are measured at the beginning and end of treatment. and also some variables are measured before and after each session. patients who participated in placebo group, when the intervention finish the investigators will be given the opportunity to receive the actual technique

the investigators selected patients diagnosed with carpal tunnel syndrome with electroneurogram, if they meet the inclusion criteria are offered to take part in this study. when the patient agree to participate and signed informed consent, the investigators collected dependent variables considered (symptoms, mechanosensitivity, functional capacity with upper limb, tractor speed of neural conduction ...) and the patient is assigned to an intervention group: real or placebo. each patient receives treatment 5 sessions trascurriendo intersessional 2- 5 days. after 5 sessions the investigators remeasured the same variables. in addition, a month later they remeasured again symptoms and functional capacity with upper limb. finally, they were shown the technique they have received. if the patient has received the technical placebo he/she is given the opportunity to receive 5 sessions of the actual technique.

Eligibility criteria:
inclusion criteria: * diagnosed medically with neurophysiological test of carpal tunnel syndrome (low and moderate intensity) exclusion criteria: * severe carpal tunnel syndrome * previous surgery on the hand * hormonal factors: diabetes, thyroids pathologies, pregnant * cervical disfunctions * ulcerations or skins disorders

Keywords: carpal tunnel syndrome physiotherapy manual therapy
postoperative delirium: brain vulnerability and recovery

Conditions: Delirium; Postoperative Complications

Summary: in this study, we propose to use eeg and a brain imaging technique known as diffuse optical tomography (dot) to study when people are in delirium and when they recovery. we plan to also compare brain function of patients who recovered from delirium to patients who did not have delirium using dot and fmri. we will also continually monitor the participant's emr to help coordinate timing of study procedures, as well as to collect information pertaining to their surgery, recovery progress, and indicators of mental status including delirium.

postoperative delirium - a mental state of confusion, inattention, and impaired thought - is a potentially life-threatening condition. as many as half of patients that have heart and non heart-related surgery will experience postoperative delirium. patients diagnosed with postoperative delirium have poorer outcomes and longer hospitalizations. unfortunately, it is an under-diagnosed condition with a variable delay in when it appears. additionally, there are no objective tools or tests that can be before or after surgery to anticipate and identify those patients who are at risk. electroencephalography \[eeg\] and functional magnetic resonance imaging \[fmri\] have helped us understand the changes in the brain during delirium. these suggest that a weakening in correlated activity within a group of brain regions, known as the default mode network (dmn), may be related to delirium.

Eligibility criteria:
common inclusion criteria: 1. age ≥ 60 2. surgery requiring cardiopulmonary bypass (cpb) for coronary artery bypass grafting, septal myectomy and/or heart valve repair/replacement 3. english speaking. common exclusion criteria: 1. implanted pacemaker 2. automatic internal cardiac defibrillator or other implant for which non-contrast magnetic resonance imaging (mri) is contraindicated 3. concomitant aortic or cerebrovascular procedure 4. inability to lay flat or still for mri 5. legal blindness or severe deafness 6. seizure history 7. known focal brain lesion larger than 3 cm. delirium case arm: 1. delirious as diagnosed by the confusion assessment method (cam)/ confusion assessment method for the intensive care unit (cam-icu) at some point during postoperative day 1-5. postoperative control arm: 1. not delirious as diagnosed by the cam/cam-icu on postoperative day 1-5.
effects of vitamin d supplementation in muscle strength and balance training

Conditions: Osteoporosis, Osteopenia; Osteoporosis, Postmenopausal

Summary: introduction: in brazil, a person who is sixty years old or more is considered elderly. the incidence of osteoporosis and osteopenia has been increasing, as have fractures resulting from falls. vitamin d deficiency can cause muscular atrophy in type ii fibers (fast contraction and strength), which can increase the risk of falls. the aging process produces reduction in the ability of postural control system to maintain postural balance, which may increase postural instability and consequently increase the elderly risk to falls. objective: to evaluate if vitamin d supplementation associated with regular exercise in vulnerable older women improves muscle strength and postural balance in 12 weeks. methods: this will be a randomized prospective clinical trial, double blind, placebo-controlled intervention. will be part of the study 40 elderly women vulnerable, who meet the inclusion criteria and that will be coming from the community through calls made by radio and social network. the volunteer will undergoing to blood test, body composition and bone mineral density, mini mental state examination, geriatric depressive scale, falls efficacy scale, whoqol-old and whoqol-bref instruments, functional capacity tests (minibest, time up and go, chair rising test, six-minute walk test), muscular strength assessment (isokinetic dynamometry, handgrip and 1rm test) and postural balance (accsway force platform for static postural balance and neurocom's balance master for dynamic postural balance) before and after 12 weeks of intervention with vitamin d supplementation and resistance and postural balance exercise. the intervention that will be perform during the 12 weeks with a progressive resistance training program.


Eligibility criteria:
inclusion criteria: 1. age \> 60 years; 2. osteoporosis or osteopenia (bone mineral density lower than -1.5 standard deviations of the t-score); 3. present hypovitaminosis d (\<30 nmol / l); 4. do not practice regular resistance exercise; 5. can not have an injury in lower limbs at least on the last three months,; 6. be able to perform independent gait without climbing for at least 100 meters; 7. be independent in your daily life activities; 8. do not present restrictions for the practice of resistance exercises, including having performed a recent exercise test (maximum 6 months); 9. do not use medications such as estrogen's, diuretics, to improve bone mass; 10. do not use dietary supplements with vitamin d; 11. do not present hyperparathyroidism, diabetes, uncontrolled hypertension, hyperprolactinemia, hypercalciuria, renal lithiasis or elevated serum calcium.

Keywords: supplementary feeding vitamin d muscle strength postural balance exercise aged
wenzhou dry age-related macular degeneration (amd) progression study

Conditions: Macular Pigment Optical Density

Summary: to evaluate the correlation between macular pigment optical density (mpod) levels and risk of progression in patients with age-related macular degeneration

age-related macular degeneration (amd) is the leading cause of blindness in the elderly.\[1\] the disease is categorized into early, intermediate, or advanced stages based on the severity of symptoms. the advanced stage, including ga and cnv, involves central region of the retina, which leads to a gradual or rapid loss of photoreceptors and central vision. the macular pigment (mp) consists of xanthophyll, which is formed from the yellow carotenoid lutein, zeaxanthin, and meso-zeaxanthin.these pigments play an important role in protecting the retina against oxidative stress through different mechanisms\[6\]. many studies have shown a various association of amd and mp.blue mountain eye study revealed low dietary intake of lutein and zeaxanthin is associated with a higher risk of amd. however, dry and wet subtypes of amd may have different etiologies and risk factors. little is known whether longitudinal study of macular pigment optical density (mpod) is related to amd progression. a comprehensive ophthalmologic examination including fundus photography,oct and mpod was performed at baseline, and semiannually thereafter for 3 years. fundus reflectance (visucam 500, reflectance of a single 460 nm wavelength) was used to measure the mpod levels. associated risk factors including body-mass index (bmi), smoking, diet, and cardiovascular diseases were documented. drusen characteristics (size, type, area), pigmentary abnormalities (increased pigment, depigmentation, geographic atrophy), and presence of abnormalities characteristic of neovascular amd were graded. for estimations of amd progression , a 9-step severity scale that combines a 6-step drusen area scale with a 5-step pigmentary abnormality scale is used. in this study, we are going to investigate a 3-year study of incidence and progression for amd and associated risk factors, in a population-based cohort of chinese aged 45 years and older living in the city of wenzhou.

Eligibility criteria:
inclusion criteria: * subject is diagnosed with either cnv, dry amd * 45 years of age or older * provides signed and dated informed consent exclusion criteria: * ocular condition in the study eye which may impact vision and confound study outcomes * presence of macular edema like retinal vascular diseases or diabetic retinopathy * active inflammation ofr infection in the study eye * high myopia（ ≥6d ）

Keywords: macular pigment optical density (mpod) age-related macular degeneration (amd) drusen chroidal neovascularization (cnv) lutein zeaxanthin
dog assisted therapy program for children with adhd

Conditions: Attention Deficit Disorder With Hyperactivity; Animal Assisted Therapy

Summary: the purpose of this study was to evaluate the efficacy of aat intervention in children with attention deficit hyperactivity disorder (adhd), in terms of improving functionality, adhd-associated symptoms, attention and working memory. participants were recruited from a community child and adolescent mental health service and a primary health care center. these objectives were accomplished through a multicenter, randomized clinical trial, open-label, two-arm study of aat for children with adhd.

the purpose of the present study was to evaluate the efficacy of animal assisted therapy (with therapy dogs) in in children with attention deficit hyperactivity disorder (adhd). the investigators conducted a multicenter, randomized, controlled, open-label, two-arm clinical trial. thirty-six children aged 7-12 diagnosed with adhd were randomized in two groups. experimental group: 14 animal assisted therapy (aat) psychoeducational sessions (once-a-week, 60 minutes) + treatment as usual and control group: treatment as usual. participants were recruited from a community child and adolescent mental health service and a primary health care center. the investigators evaluated changes on functionality, adhd-associated symptoms, attention and working memory at pre-treatment and post-treatment. assessment included intelligence test, adhd symptoms referred by parents and teacher's (conners rating scale), attention measures (conners continuous performance test (cpt-3) and children's functioning (children's global assessment scale (cgas)).

Eligibility criteria:
inclusion criteria: * age between 7 and 12 years old (included). * diagnosis of adhd confirmed at the child and adolescent mental health service. * intelligence quotient of 80 or higher. * delivery of the information sheet and signature of the informed consent. exclusion criteria: * if in the initial interview they declared having allergy or fear of dogs. * history of aggression towards animals. * co-morbidity with other disorders (conduct disorders, autism spectrum disorders, anxiety disorder or depression). * if the treatment regimen was modified during the intervention period.

Keywords: animal assisted therapy attention deficit disorder with hyperactivity children primary health care center psychotherapy psychiatry
effect of two methotrexate in sync with the first adalimumab to prevent the immunisation anti ada in spondyloarthritis

Conditions: Spondyloarthritis

Summary: preliminary report have demonstrated that methotrexate induces an anti bio-medicament tolerization whan administrated just before the first administration of the bio-medicament. once this tolerization is obtained it seems useless to continue the methotrexate because this treatment has no efficacity in cases of spondyloarthritis.

spondyloarthritis are treated in first intention by nsaids but in case of inefficacity biotherapies that inhib the tnf are used. adalimumab is the most used anti tnf in this indication. monoclonal antibody uses in therapy is immunogene, and there is a clear link between increase of anti drug antibody and in one hand decrease of drug serum concentration and in an other failure of the therapeutic response. with adalimumab there is an apparition of adab in 30%. there are reports suggesting that adding methotrexate to the therapy in a specific timeline allow to prevent the immunization. a previous study shows that association in long terms between methotrexate and adalimumab induce less immunized patients. the investigator's goal is to assess if two methotrexate subcutaneous injections at day 1 and 2 could prevent anti adalimumab antibodies formation.

Eligibility criteria:
inclusion criteria : * patients aged from 18 to 90 * patients suffering from axial spa, radiographic or non-radiographic according to asas criteria (peripheral involvement and/or inflammatory bowel diseases could be present). * indication for anti tnf treatment: resistance to at least 2 nsaids and no contraindication to adalimumab * no previous treatment with methotrexate in the last 3 months * stable dosage of steroids (less than 10mg/day of prednisone equivalent) and/or of nsaids for at least 10 days * contraception feminine or masculine * informed and written consent * social insurance exclusion criteria : * contraindication to methotrexate * previous treatment with adalimumab * steroids more than 10mg/day of prednisone equivalent * previous treatment with: * etanercept in the last month * infliximab, golimumab, certolizumab in the last 2 months (previous treatment hereafter these dates with anti-tnf except adalimumab or secukinumab are not a counterindication) * current immunosuppressive drugs except methotrexate * current and proven pregnancy * project of pregnancy in the next 3 months following inclusion * legal safeguards * inclusion in another interventional research project

Keywords: adalimumab anti-drug antibodies tolerization methotrexate spondyloarthritis
optical measurement of cerebral hemodynamics in children with acute arterial ischemic stroke

Conditions: Acute Arterial Ischemic Stroke

Summary: acute ischemic stroke affects roughly 1 in 50,000 children every year and is one of the top ten causes of death in children. currently, caregivers lay the affected child flat in hopes of increasing blood flow to the brain and reducing the volume of the brain which is damaged. however, there are currently no techniques to measure brain blood flow at the child's bedside and indicate if this treatment is effective. we will probe brain blood volume, oxygen saturation, and flow with red light to determine the efficacy of this intervention.

arterial ischemic stroke (ais) affects about 2 children per 100,000 per year and is one of the top 10 causes of mortality in children. after stroke, there is a disturbance in cerebral blood flow (cbf) autoregulation, and changes in head position may change cbf. currently, practice at the children's hospital of philadelphia (chop) is to keep the head of bed (hob) of a child with ais flat for 24 hours; however, there is no evidence that this practice is efficacious in children. furthermore, maintaining a child supine for 24 hours is uncomfortable for the child and is often unenforceable in younger children. this study will use a noninvasive optical technique to measure cbf as hob position is changed to assess the effectiveness of head of bed position in increasing cbf in children with acute arterial ischemic stroke. the primary objectives are to determine the difference in cbf at hob flat (0 degrees) and hob at +30 degrees in healthy children and in children with ais. the secondary objectives are to examine cbf in healthy children and in children with ais at other hob angles (0, +15, and +30 degrees) compared to the cbf at hob 0 degrees and to determine if the position that maximizes cbf varies over time from stroke onset.

Eligibility criteria:
inclusion criteria healthy control subjects 1. subjects age 2-18 years inclusive 2. no history of congenital or acquired brain injury 3. no history of developmental delay, mental retardation, genetic or metabolic syndrome affecting the brain inclusion criteria ais subjects 1. subjects age 2-18 years inclusive 2. 72 hours or less from stroke onset 3. mri or ct confirmation of ais exclusion criteria for all subjects 1. skull defect preventing application of probes 2. moyamoya disease 3. sickle cell anemia