Kornimate/medical-research-clean huggingface dataset:
aflibercept intravitreal injection for myopic choroidal neovascularization

Conditions: Choroidal Retinal Neovascularization

Summary: the purpose of this study is to evaluate the clinical results of anti-vegf intra-vitreal injections (ivt) in cnv secondary

twenty consecutive patients (30 eyes) with subfoveal pm-cnv, 9 of whom had been unsuccessfully treated with visudyne pdt, were treated with ivt of 0.5mg ranibizumab. etdrs best corrected visual acuity, macular thickness on oct scans, and angiographic features were recorded and evaluated. the aspect of oct scans passing across the pm-cnv was also analyzed. ivts were repeated only in case of persistent angiographic leakage and if oct scans showed retinal thickening or edema and serous retinal detachment. the follow-up period was at least 6 months

Eligibility criteria:
inclusion criteria: * myopic and cnvm exclusion criteria: * patients with poor compliance * patients with uncontrolled diabetes and hypertension or any other medical condition that increase the risk of complications like recent history of stroke or myocardial infraction (\< one year). (physician clearance was obtained for all patients). * age related macular degeneration with juxtafoveal and subfoveal cnvm: recurrent cnvm following pdt and ttt with ivta. patient who could not afford pdt, macugen or lucentis which is fda approved. * patients who had undergone major surgery 28 days before, were excluded from the study and it was also suspended prior to elective surgery. * refractory macular oedema due to vein occlusion, pseudophakia, clinically significant macular oedema (csme) etc. that affects vision and does not respond adequately to usual treatment methods. * proliferative diabetic retinopathy, non-resolving vitreous haemorrhage with pdr. * idiopathic cnvm, inflammatory cnvm and other conditions associated with cnvm.

Keywords: aflibercept myopia complications neovascularization oct
effect of laser application in pain management following the use of orthodontic elastomeric separators

Conditions: Orthodontic Treatment

Summary: the aim of this study is to evaluate the effect of low level laser therapy (lllt) on pain management in people commencing orthodontic treatment. the study design is a randomized controlled trial. participants' pain will be dealt with by laser irradiation in one side of the jaw randomly, and the other side will be treated by a placebo procedure. pain assessment will be measured using visual analog scales (vas). the hypothesis of this study is that laser irradiation decreases the amount of pain following the insertion of orthodontic separators.

here we have two groups: the first group will undergo one dose of irradiation which is going to be applied on one side of the mouth whereas the opposing side will serve as a control side (placebo). the second group will undergo two doses of irradiation which is going to be applied on one side of the mouth whereas the opposing side will serve as a control side (placebo).

Eligibility criteria:
inclusion criteria: * participants should have healthy periodontal structures, healthy teeth. * presence of first molar in both side of the jaw. exclusion criteria: * systemic diseases * chronic pain or neurological pain

Keywords: low level laser therapy elastomeric separator placebo visual analog scale laser irradiation
comparison of kinesio-taping and rigid-taping on vertical jump in individuals with pes planus

Conditions: Pes Planus

Summary: the effects of kinesio-taping and rigid-taping on vertical jump performance have been investigated; however, results remain unclear.

the effect of kinesio-taping and rigid-taping on controlling foot pronation remains unclear due to contradicted results. moreover, to our knowledge, there is not any study to elucidate the effect of rigid-taping on vertical jump performance. therefore, the investigators hypothesised that rigid-taping would be more effective on vertical jump performance because of its direct mechanical correction in pes planus, and the study was aimed to compare the effects of kinesio-taping and rt on vertical jump performance in sedentary adults with pes planus.

Eligibility criteria:
inclusion criteria: * male and female individuals between the ages of 18-35, * individuals without any chronic disease exclusion criteria: * those with lower extremity injuries in the last 1 year, * those with a history of lower extremity surgery and visual or vestibular disorders, * those with other foot deformities accompanying pes planus,
psychometric characterization of patients with cardiac arrhythmias

Conditions: Cardiac Arrhythmia; Anxiety; Personality; Psychological Stress; Depression

Summary: to investigate the influence of different psychological parameters (e.g. depression, anxiety, personality traits, resilience, tolerance of uncertainty or heart beat perception) on treatment outcome and quality of life in patients with cardiac arrythmias.

this longitudinal observational study examines patients with cardiac arrhythmia (such as atrial fibrillation or atrial flutter) who are undergoing a conventional standard therapy in the department of cardiology of the charité - universitätsmedizin berlin, campus benjamin franklin. to examine the impact of psychological symptoms such as anxiety, depression, resilience and risk factors (e.g. neuroticism) on cardiac treatment outcomes, patients are evaluated with a standardized psychological assessment including established questionnaires. the baseline observation is performed before the standard treatment of the arrhythmia (e.g. pharmacological treatment or electrophysiological methods). follow-up observations are made 3 and 6 month after the cardiological intervention.

Eligibility criteria:
inclusion criteria: * age of majority (min. 18 years old) * no severe cognitive dysfunction * diagnosed cardiac arrhythmias * reason of admission is the treatment of cardiac arrhythmia exclusion criteria: * medium to severe cognitive dysfunction * doubt on capacity to give consent

Keywords: cardiac arrhythmia, personality, psychological symptoms
effects of core stability exercises and cognitive tasks on chronic non-specific back pain

Conditions: Chronic Non-specific Low Back Pain

Summary: this randomized control trial study aims to compare the effect of core stability exercises and cognitive tasks with general exercises and cognitive tasks on pain, disability, and postural control strategies of chronic non-specific low back pain patients. the main questions are: 1. are core stability exercises and cognitive tasks more effective than general exercises and cognitive tasks in reducing the pain of chronic non-specific low back pain patients? 2. are core stability exercises and cognitive tasks more effective than general exercises and cognitive tasks in reducing the disability of chronic non-specific low back pain patients? 3. are core stability exercises and cognitive tasks more effective than general exercises and cognitive tasks in improving postural stability parameters of chronic non-specific low back pain patients? 4. are core stability exercises and cognitive tasks more effective than general exercises and cognitive tasks in improving stabilogram diffusion analysis parameters of chronic non-specific low back pain patients? this study is designed to apply two exercise protocols on two groups of 17 people with non-specific back pain. group a will receive core stability exercises along with cognitive tasks, and group b will receive general exercises along with cognitive tasks.

patients will be aged between 18-50 years. all patients meeting the inclusion criteria will receive 16 training sessions (thrice a week). the primary outcome measure will be pain and disability. secondary outcome measures will be postural control strategies (including postural control stability and stabilogram diffusion analysis), quality of life, fear of movement, and fear-avoidance beliefs that will be assessed before and after training sessions and at 3-month follow-up; only primary outcomes will be evaluated in each group.

Eligibility criteria:
inclusion criteria: * orthopedist-confirmed diagnosis of chronic nonspecific low back pain that has lasted at least three months since its onset. * pain score of 3 or more on a visual analog scale. * pain during quiet standing. * cognitive level above 24 based on mini-mental state examination (mmse). exclusion criteria: * radicular pain and any neurological signs. * uncorrected vision impairment. * hearing problems. * vestibular dysfunctions. * cognitive deficit. * previous spinal surgery. * severe deformity or injury to the lower extremities.

Keywords: low back pain disability postural control core stability exercise cognitive task
intensive care nurses' training package on the safety culture of geriatric patients

Conditions: Safety

Summary: this study aims to determine the effect of intensive care nurses' training package on the safety culture of critically ill geriatric patients. study hypothesis: intensive care nurses who receive the proposed training package exhibit higher scores on critically ill geriatric patients' safety culture awareness than those who do not receive it.

the researchers will prepare the proposed nurses' training package program. the program will be planned to be carried out in 10 sessions that will be classified into; sessions regarding knowledge about the age-related changes affecting elderly patients that should be considered while caring for them and how to care for and maintain the safety of the critically ill geriatric patients. the researchers will prepare an illustrative powerpoint presentation of each study program's session.

Eligibility criteria:
inclusion criteria: * aged 20 years and above. * provide direct care for critically ill geriatric patients. * work for at least 1 month in the unit. exclusion criteria: • not involved in patient care.

Keywords: geriatric patients critically ill
an evaluation of the safety and clinical utility of handheld ecg technology in psychiatry

Conditions: Cardiovascular Diseases; Dementia; Mental Health Disorder

Summary: acetylcholinesterase inhibitors and antipsychotics are drugs commonly prescribed in psychiatry, the former for dementia and the latter for acute and chronic psychotic illness. both can cause cardiac arrhythmia therefore 12 lead ecg's are recommended before prescribing. the test is often difficult to obtain however, leading to either patients being inconvenienced or drugs prescribed without the test. there are two parts of this study, but both examine the utility of single lead ecg monitoring, one in the memory clinic and the other in inpatient psychiatry wards. the aim to to evaluate the safety and efficacy of the handheld ecg versus the 12 lead and 6 lead ecg, and whether the handheld ecg can be used to screen for ecg abnormalities that would generally lead to a caution or contra-indication for acetylcholinesterase inhibitors and anti-psychotic medication. patients will either be recruited from the outpatient memory clinic or in patient psychiatry wards. following informed consent baseline demographic data will be collected, and patients will undergo a 12 lead and 6 lead ecg as well as a rhythm strip using the handheld device. data from this point will be annonymised for future analysis. the psychiatrists ecg report will also be recorded, and a subset of patients will undergo an echocardiogram (to see what proportion of patients with psychiatric disorders have structural heart disease.)


Eligibility criteria:
inclusion criteria: any patient attending the memory clinic any patient admitted to the acute psychiatric ward requiring antipsychotic medication exclusion criteria: patients who lack capacity and do not have a personal consultee to provide assent
comparative study of the efficacy of hyaluronic acid, dry needling and combined treatment in patellar osteoarthritis

Conditions: Osteoarthritis

Summary: randomized clinical trial in patients with knee osteoarthritis. sixty patients will be evaluated, divided in three groups (20 in each). one group a will be treated by dry needling in the vast internal, other group b will be treated with a standardized treatment protocol (electrotherapy and manual therapy), and group c will be treated with hialuronic acid. the investigators want to observe which technique is the most effective in osteoarthritis.


Eligibility criteria:
inclusion criteria: * patients with knee pain and diagnosed of osteoarthritis knee and confirm rnm * more 18 years. * less 55 years exclusion criteria: * more 55 years. * less 18 years. * mental dysfunction * those who have any type of complication that can cause myofascial or neuropathic pain in the lower limb, such as lumbo-sacral radiculopathy, neuropraxia, neurothymesis, axonotmesis, or meralgia paraesthetica; who have any condition generally considered to be a factor in perpetuating trps, such as fibromyalgia, hypothyroidism, or iron deficiency; and patients who may have a fear of needles (belonephobia) will be excluded. patients with lower limb dysmetries of 0.50 cm or more were also excluded from this study.
osteogenic action of a biphasic bioceramic with statin in a third molar extraction model

Conditions: Bone Loss; Regenerative Inflammation

Summary: the clinical study aims to assess the osteogenic effects of galibone+ in bone regeneration post-extraction of impacted mandibular third molars.

with a focus on both clinical and radiological outcomes, the study seeks to compare the efficacy of galibone+ against a standard material (bio-oss) through a double-blind, randomized split-mouth trial involving 30 patients. variables including pain, inflammation, and post-surgical complications will be monitored during the initial seven-day follow-up, while bone volume reduction and mineral density will be evaluated radiographically over a six-month period. the study's findings promise to shed light on the potential of galibone+ as a promising adjunct in enhancing bone regeneration following dental extractions, thereby advancing oral surgical practices and patient outcomes.

Eligibility criteria:
inclusion criteria: * participants must be of legal age. * participants must provide informed consent for participation in the study. * participants must require extraction of both impacted mandibular third molars. * both impacted molars must exhibit a similar level of complexity for extraction. * participants must have no history of infection in the impacted molars prior to extraction. * participants must not have any contraindications to undergoing oral surgical procedures (asa i/ii classification). exclusion criteria: * participants with severe mental disorders that may impair their ability to provide informed consent or follow study instructions. * participants currently receiving medications contraindicated for dental extractions. * participants under the age of legal consent. * participants who have undergone head and neck radiotherapy within the past 18 months.
effects of pha hemoperfusion plus hemodialysis on protein-bound uremic toxins

Conditions: End Stage Renal Disease on Dialysis

Summary: this single-center, prospective cohort study evaluates whether adding the pha130 hemoperfusion cartridge to conventional hemodialysis (hd) or hemodiafiltration (hdf) more effectively reduces protein-bound uremic toxins-specifically indoxyl sulfate (is) and p-cresyl sulfate (pcs)-in maintenance hd patients. adults on thrice-weekly, 4-hour hd for at least three months are randomized to one of three arms: hd/hdf alone; hd/hdf plus biweekly pha130 hemoperfusion; or hd/hdf plus biweekly ha130 hemoperfusion. after a four-week washout, toxin levels are measured at baseline and again at weeks 4, 12, and 24, with the primary endpoint being the reduction in is and pcs at week 24. secondary endpoints include single-session toxin removal, middle-molecule clearance (β₂-microglobulin, pth), patient-reported outcomes (itching, sleep, quality of life), and rates of hospitalization and mortality. safety is closely monitored through adverse event reporting and consistent anticoagulation dosing. findings will clarify the clinical value of pha130 hemoperfusion for improving toxin clearance and guiding optimal dialysis strategies.


Eligibility criteria:
inclusion criteria: 1. age ≥18 years, with no restriction on gender; 2. undergoing regular hemodialysis 3 times per week, 4 hours per session, and has received maintenance hemodialysis treatment for ≥3 months; 3. willing and able to receive treatment as per the protocol requirements, and has signed the informed consent form for subjects. exclusion criteria: 1. patients receiving combined hemodialysis (hd) and peritoneal dialysis (pd) treatment; 2. patients with known allergy to hemoperfusion device materials, contraindications, or intolerance to the device; 3. patients with acute severe infection, severe cardiopulmonary insufficiency, severe cerebrovascular disease, severe bleeding tendency, or active bleeding; 4. patients with malignant tumors in the active stage or undergoing treatment for malignant tumors; 5. patients with a platelet count \< 60 × 10⁹/l; 6. other conditions deemed unsuitable for enrollment in this study by the researchers.

Keywords: hemoadsorption hemodialysis
evaluating improvement strategies in addiction treatment

Conditions: Addiction

Summary: addiction treatment is often characterized by long delays between first contact and treatment as well as high no-show and drop out rates leading to unused capacity in apparently full agencies. patients do not get needed care and agency financial stability is threatened. the network for improvement of addiction treatment (niatx) began as a high-intensity improvement collaborative of 39 addiction treatment agencies distributed across 25 states. niatx substantially improved time to treatment and continuation in treatment by making improvements to organizational processes (such as first contact, intake and assessment, engagement, level of care transitions, paperwork, social support, outreach, and scheduling) in preliminary studies. while the results are very encouraging, they have, by intent, been obtained from a select group of agencies using a high-cost combination of services. a more practical diffusion model is needed to spread process improvements across the spectrum of treatment agencies. this study is a cluster-randomized trial to test the effectiveness and cost of less expensive combinations of the services that make up the niatx collaborative (interest circles, coach calls, coach visits and learning sessions).

this cluster-rct randomly assign 201 treatment agencies in 5 states to four experimental arms. the agencies were randomized to an intervention for 18 months with a 9 month sustainability period. the study aimed to: 1) determine whether a state-based strategy can (with niatx support) can lead mainstream treatment agencies to implement and sustain process changes that improve the study's primary outcomes: time to treatment, annual clinic admissions, and continuation in treatment; and 2) evaluate the effectiveness and cost of the services making up niatx. this study aims to create a practical model for improving efficiency and effectiveness of addiction treatment.

Eligibility criteria:
inclusion criteria: * at least 60 admissions/year * provide outpatient and intensive outpatient levels of care (as defined by asam) * provide or use detox services provided by others * have tax-exempt or government status or rely on public funding (e.g., block grants, medicare, medicaid, local government, private philanthropy) for at least 50% of their budget * have adopted no more than two of the planned interventions exclusion criteria: * are current niatx members

Keywords: organizational change process improvement addiction treatment cost effectiveness study
a grapefruit feeding trial in healthy, overweight adults

Conditions: Weight Loss; Obesity; Cardiovascular Risk Factors

Summary: folklore has suggested that consuming grapefruit may promote weight control. sparse data exist to support this hypothesis, though there is some evidence of health promotional effects regarding blood pressure and lipid profiles. the aims of this randomized controlled trial are to determine the role of grapefruit in: 1. reducing weight 2. reducing blood pressure 3. reducing inflammation 4. improving the lipid profile. the investigators hypothesize that six weeks of daily consumption of grapefruit will reduce weight, blood pressure, and inflammation while improving the lipid profile in overweight, healthy adults.


Eligibility criteria:
inclusion criteria: * adults, men and premenopausal women * bmi: 25-45 kg/m2 * willing to maintain current exercise regimen (not to exceed 10 hours/week) * willing to follow a diet low in bioactive rich fruits and vegetables and with no citrus exclusion criteria: * history of chronic disease * metabolic disease * inflammatory disease * high cholesterol (\>225 mg/dl) * smoker * taking medications metabolized by the cytochrome p450 3a enzyme * history of alcohol or drug abuse

Keywords: grapefruit weight loss blood pressure lipids inflammation
virtual reality in rehabilitation of executive functions in children with attention deficit hyperactivity disorder.

Conditions: Attention Deficit Hyperactivity Disorder

Summary: attention deficit hyperactivity disorder (adhd) is caused by an abnormality in the development of the central nervous system. children with attention and executive function difficulties often need long-lasting rehabilitation and there is an increasing need for timely, cost-effective, and feasible rehabilitation interventions, where the training is targeted to support everyday life functional capacity. the use of virtual reality (vr) in the rehabilitation of children with attention and executive function deficits offers opportunities to practice skills required in everyday life in environments emulating real-life situations. the major aim of this research project is to develop a novel effective vr rehabilitation method for children with deficits in attention, activity control and executive functions by using the virtual environment that corresponds to the typical everyday life. in this randomized control study vr glasses are used to present the tasks, and the levels of difficulty are adjusted according to the child's progress. researchers expect that; 1) intensive training improves the attention regulation, activity control skills and executive functions of the children in the intervention group; 2) training of executive skills with motivating tasks in a virtual environment that is built to meet challenging everyday situations transfers to the child's everyday life, 3) the duration of the training effect does not depend on the success of the vr training itself, but on how well the child adopts new strategies that make everyday life easier and how the parent is able to support the child's positive behaviour in everyday life.


Eligibility criteria:
inclusion criteria: * diagnosis of adhd (icd-10 f90.0) and * methylphenidate medication and * age 8-12 years and * finnish as a native language exclusion criteria: * sensitivity to flashing light, * epilepsy (icd-10 g40), * mental retardation (icd-10 f70-f79), * pervasive developmental disorders (icd-10 f84), * inflammatory diseases of the central nervous system (icd-10 g00-g09), * severe cerebral palsy syndrome (icd-10 g80, gmfcs 4-5, macs 3-5), * traumatic brain injury ((icd-10 s06), * brain tumour, and * multiple pregnancy

Keywords: attention deficit hyperactivity disorder attention executive function virtual reality child