Kornimate/medical-research-clean huggingface dataset:
postoperative effects of preoperative anxiety

Conditions: Anxiety; Pain, Postoperative

Summary: introduction patients who will have obesity surgery have about %48 psychiatric illnesses like anxiety disorder. studies which analyze the relationship between preoperative anxiety level and postoperative pain had reported conflicting results. the aim of this study is to search the relationship between preoperative anxiety level and postoperative pain and analgesic consumption in patients who had laparoscopic sleeve gastrectomy surgery. material and methods our prospective double-blind study is planned to require 86 female patients aged between 18-65 years old, american society of anesthesiologists (asa) i-ii and body mass index (bmi) ≥40 kg/m\^2. patients having a psychiatric or neurologic disease, brain damage, using psychiatric medications (antidepressants, anxiolytics) and chronic alcohol, known allergy to medications used in the study protocol, inability to provide informed consent will be excluded. patients will be wanted to fill the spielberger's state-trait anxiety inventory the night before the surgery. the analgesic consumption of the patients will be recorded by evaluating the pain with visual analog scale (vas) and sedation status with ramsay's sedation scale in the 1st, 4th, 12th and 24th hour of postoperative period. expectations and scientific contributions more satisfying postoperative analgesia may be provided in this group of patients by determining correlation between preoperative anxiety level and postoperative pain and analgesic consumption in patients who had laparoscopic sleeve gastrectomy. morbidity rate related with pain may be decreased and patient satisfaction may be increased.


Eligibility criteria:
inclusion criteria: * female patients aged between 18-65 years old * asa i-ii * bmi ≥35 kg/m\^2 exclusion criteria: * having a psychiatric or neurologic disease * brain damage * using psychiatric medications (antidepressants, anxiolytics) and chronic alcohol * known allergy to medications used in the study protocol

Keywords: preoperative anxiety level postoperative pain laparoscopic sleeve gastrectomy
biomarker identification in orthopaedic & oral maxillofacial surgery subjects to identify risks of bisphosphonate use

Conditions: Osteoporosis, With or Without Treatment; Bisphosphonate Treatment; Atypical Femur Fracture; Bisphosphonate Related Osteonecrosis of the Jaws (BRONJ); Healthy Volunteers

Summary: bisphosphonates are drugs that prevent bone loss by blocking the activity of cells that normally resorb bone. the most common examples of these drugs are boniva and fosamax. these drugs are available for oral or intravenous dosing and are prescribed at daily, weekly, biweekly, or monthly intervals. among the many thousands of individuals who currently take these medications, certain individuals experience "atypical" femur fractures preceded by prodromal pain, changes in cortical thickening of bone, or bisphosphonate related osteonecrosis of the jaws (bronj). osteonecrosis of the jaws is defined as exposed bone of the jaws for 8 weeks or more and requires surgical treatment. this study will attempt to identify genomic and rna biomarkers that may play a role in differential metabolism of bisphosphonates or indicate tendency toward the severe adverse events associated with these drugs.

collected specimens were subjected to affymetrix dmet™ plus solution analysis. manuscript is in preparation.

Eligibility criteria:
inclusion criteria: * any adult (male or female) age 18 or over meeting any of the following criteria: * all participants must be able to provide informed consent for themselves. * history of bp treatment with or without bronj and/or femur fracture (typical or atypical) * no history of bp treatment with or without bronj and/or femur fracture (typical or atypical) exclusion criteria: * children age 17 or younger * adults who cannot or do not make medical decisions for themselves * persons known to be under the jurisdiction of the department of corrections * individuals who are pregnant.

Keywords: aclasta actonel alendronate alendronate/cholecalciferol aredia atelvia boniva didronel etidronate fosamax fosamax plus d ibandronate pamidronate reclast risedronate skelid tiludronate zoledronic acid zometa bisphosphonate atypical femur fracture (aff) osteoporosis bisphosphonate related osteonecrosis of the jaw (bronj)
study in unsettled infants experiencing feeding intolerance

Conditions: Feeding Disorder

Summary: multinational, multicenter, clinical trial. to evaluate the effect of an experimental formula on gi symptoms and associated behaviors in unsettled infants with parent-reported feeding intolerance

the purpose of the present study is therefore to evaluate the effect of an experimental formula in an unsettled formula-fed infant population whose parents are considering switching formulas due to perceived feeding intolerance.

Eligibility criteria:
inclusion criteria: 1. full term infants, singleton, healthy at birth 2. infants of parent(s)/lar who have previously made the decision to exclusively formula feed their infant. 3. infants exclusively consuming a standard formula for a minimum of 3 consecutive days prior to enrolment. 4. infant's parent(s)/lar are of legal age of consent and are willing and able to fulfil the requirements of the study protocol. exclusion criteria: 1. infants who are consuming any amount of supplemental human milk 2. infants who are consuming weaning foods or beverages other than infant formula 3. infants with known cow's milk allergy or family history of siblings with documented cow's milk protein intolerance/allergy 4. infants who have a medical condition or history that could cause or contribute to feeding intolerance 5. infants who received any other investigational intervention or who have participated in another clinical trial prior to enrolment
the efficacy and safety of topical vitamin d drop on meibomian gland function in patients with meibomian gland dysfunction

Conditions: Meibomian Gland Dysfunction

Summary: in this randomized clinical trial, patients with meibomian gland dysfunction aged 50 year and more will be enrolled. the meibomian gland dysfunction diagnosis will confirmed by a cornea specialist. the enrolled patients will be randomly allocated to the treatment and placebo group. the patients in treatment group will receive topical vitamin d every 6 hours daily (25 microgram/cc or 1000 iu). the control group will receive the same-shape packed drop without vitamin d. the patients in both group will receive the conventional treatment including hot compress and shampoo scrub. the primary outcome is the change in ocular surface disease index and 5-item dry eye questionnaire score assessed before the topical treatment and every one-months until 3 months. the secondary outcome measures are tear breakup time, schirmer test, corneal fluorescein staining, meibomian gland expressibility. the grader and the patients will blind to the study group.


Eligibility criteria:
inclusion criteria: * patients aged more than 50 years old and suffering from dry eye caused by meibomian gland dysfunction. exclusion criteria: * patients with vitamin d deficiency * patients taking vitamin d systemic supplementation * patient with prior ocular surgeries within previous 6 months. * patient with other causes of dry eye, such as aqueous tear deficiency or ocular surface disease
therapist adherence to cognitive-behavioral therapy

Conditions: Depression; Anxiety Disorders

Summary: an observational web-based survey on therapist adherence to evidence-based cognitive-behavioral therapy (cbt) in the perspective of their patients with depression or anxiety disorders in psychiatric outpatient care in stockholm, sweden. following completion of cbt, participants respond to questions including their age, gender, education, whether they have improved, whether they considered treatment helpful, and an instrument measuring therapist adherence to cbt procedures (e.g., setting agenda, follow up on home assignments) and cbt techniques (e.g., exposure, cognitive restructuring). the purpose of the study is to contribute to quality assurance of cbt in stockholm health care services.


Eligibility criteria:
inclusion criteria: * a primary diagnosis of major depressive disorder, social anxiety disorder, panic disorder, agoraphobia, generalized anxiety disorder, obsessive-compulsive disorder, post-traumatic stress disorder, or illness anxiety disorder * 18 years of age or older * just completed individual cognitive-behavioral therapy in psychiatric outpatient care in stockholm, sweden exclusion criteria: * none
negative pressure wound therapy -prevena in prevention of infections after total knee arthroplasty (tka)

Conditions: Total Knee Replacement

Summary: this trial is a prospective, single center, unblinded, randomized, controlled study to assess the safety and efficacy of negative pressure wound therapy in preventing infections after tka surgery . the study will enroll 316 patients that will undergo tka. patients will be randomized to the treatment group and undergo the study intervention - (npwt) the intervention will take place at the end of the surgery. the patients that are randomized to the control group will receive standard treatment. both groups will be assessed at two weeks and six weeks. period.


Eligibility criteria:
inclusion criteria: * ages: 18 to 80 * males- not involved in active military duty. * females-non child bearing potential, or females of child-bearing potential who have a negative pregnancy test (hcg urine) within 72 hours of informed consent. exclusion criteria: * active systemic or local infection. * history of malignancy, radiotherapy, or chemotherapy for malignancy (except bcc of the skin) * active autoimmune disease. * any past or present immunosuppressive treatment. * current treatment with chemotherapeutic agents * history of metabolic bone disease (primary or secondary). * chronic renal insufficiency (defined by 50% increase of normal levels).
the effects of ozone therapy on wound healing

Conditions: Wound Heal

Summary: the aim of present study was to evaluate effects of ozone therapy on wound healing after gingivectomy and gingivoplasty operations as a model of secondary wound healing.. twenty three systemically healthy individuals participated in this study. ozone was applied immediately after surgery, at 1st day and 3rd day after gingivectomy surgery. in the photographs of the wounds, the difference in color were evaluated and measurements were performed at the baseline, 3rd, 7th, 14th days after surgery.

although ozone therapy has often been tried in medical science and has become more popular due to its antimicrobial, biocompatibility and healing properties, the effects of ozone therapy on surgeries that heals with secondary intention were not studied. in the lights of these informations, the aim of present study was to evaluate effects of ozone therapy on wound healing after gingivectomy and gingivoplasty operations as a model of secondary wound healing. twenty three systemically healthy individuals participated in this study. all periodontal examinations were performed by one experienced examiner and non-surgical periodontal treatment of the patients were performed within two weeks after initial examination by the same clinician.gingivectomy and gingivoplasty operations were performed by another examiner who was unaware of the study protocol.after gingivectomy and gingivoplasty, right quadrants of the surgical areas were assigned to receive ozone therapy in all patients. ozone therapy was also performed by an experienced periodontist. as placebo application, left quadrants received regular air from the ozone generator.postoperative pain was assessed at 3rd, 7th, 14th days after surgery with a visual analog scale at baseline and 3rd, 7th, 14th days after surgery, surgical area was disclosed by a plaque disclosing solution to visualize the epithelization degree of the surgical areas. solution provided a clear vision to distinguish normal gingiva from the areas in which the gingival epithelium is absent, abraded or lacking sufficient keratinization. in order to evaluate epithelization degree of the wounds, standardized photographs were taken from each patient.in the photographs of the wounds, the difference in color were evaluated and darkly stained areas were considered as lack of enough epithelization. these measurements were performed at the baseline, 3rd, 7th, 14th days after surgery. the determinations were done by a calibrated examiner who was blind to test and control sites

Eligibility criteria:
inclusion criteria: * 18 to 35 years of age * systemically healthy * non-smokers * no medications taken for 6 months * no pregnancy and lactation * no contraindications for periodontal surgery * no gingivectomy or mucogingival surgical history in the lower incisor region. exclusion criteria: * \ 35 years of age * systemical disease * smoking and alcohol consumption * medications taken for 6 months * pregnancy and lactation * contraindications for periodontal surgery * gingivectomy or mucogingival surgical history in the lower incisor region.
surface electromyography in stratifying chronic low back pain.

Conditions: Low Back Pain

Summary: surface electromyography can be utilised to detect normal muscle electrical activity during maximum forward flexion termed flexion relaxation response (frr)

in this study, our primary objective is to assess frr and disability (odi) correlation protocol as an objective tool in stratifying chronic lbp. we also would like to evaluate the relationship between frr with pain intensity and lumbar range of motion as our secondary objective.

Eligibility criteria:
inclusion criteria: * participants aged between 20 - 70 years old * mechanical lbp \> 6 weeks (not acute lbp) * not received any specific exercise spinal manipulation or surgery to improve lbp within the last 3 months. exclusion criteria: * pregnancy * radicular lbp patients or specific-spinal pathology / "red-flags". * surgical intervention for the current lbp complaint (includes traumatic causes of lbp with surgical intervention) * cognitive or communication difficulty preventing active participation in exercises or communicating pain scores
understanding participation habits among plaque psoriasis patients

Conditions: Plaque Psoriasis

Summary: the study intends to investigate the personal experiences of plaque psoriasis patients who take part in a separate clinical study including a specific medication intervention. the major focus will be on closely following individuals' rates of trial completion and withdrawal. the data collected from this study will help improve future outcomes for all plaque psoriasis as well as those in under-represented demographic groups.


Eligibility criteria:
inclusion criteria: * patients diagnosed with plaque psoriasis * aged ≥ 18 years old and ability to provide written informed consent obtained prior to participation in the study and any related procedures being performed * subjects willing and able to comply with the protocol for the duration of the study including undergoing treatment and scheduled visits and examination. exclusion criteria: * refusal of consent * women of childbearing potential without a negative pregnancy test; or women who are lactating. * any serious and/or unstable pre-existing medical disorders

Keywords: plaque psoriasis
the effect of preoperative nlr level on epidural analgesia application in thoracotomy

Conditions: C23.550.767.700; C23.550.470

Summary: the aim of this study is to investigate the relationship of preoperative neutrophil/lymphocyte ratio (nlr) with postoperative pain and the effect of preoperative nlr level on timing of epidural analgesia in thoracotomy.

the study was conducted prospectively in 60 patients aged 18-75 years, asa i-iii, who underwent thoracotomy. the patients were divided into 2 groups as nlr level above 2 (group a) (n:32) and nlr level below 2 (group b) (n:28). each group was divided into subgroups with equal numbers of prempative analgesia group and control group. local anesthetic was administered to the preemptive analgesia group (group p) 20 minutes before the surgical incision through the epidural catheter, and to the control group (group k) 20 minutes before the patient was awakened from the epidural catheter. nrs levels and additional analgesia needs were recorded at 2, 4, 8, 12 and 24 hours postoperatively.

Eligibility criteria:
inclusion criteria: * patient graded as american society of anesthesiologist (asa) physical status, i, ii or iii * patient subjected to thoracotomy operation exclusion criteria: patient having morbid obesity, * patient having renal failure, * patient having hepatic failure, * patient having neuropsychiatric disease, * patient allergy to the study drugs

Keywords: preemptive epidural analgesia, neutrophil/lymphocyte ratio, i̇nflammation
phase 3 efficacy and safety study of cd07805/47 topical gel in subjects with facial erythema associated with rosacea

Conditions: Rosacea

Summary: phase 3 efficacy and safety study of cd07805/47 topical gel in subjects with facial erythema associated with rosacea. the study hypothesis is that cd07805/47 gel, applied topically once daily is more efficacious than vehicle and provides an acceptable safety profile in the treatment of facial erythema associated with rosacea.


Eligibility criteria:
key inclusion criteria: 1. male or female who is at least 18 years of age or older. 2. a clinical diagnosis of facial rosacea. 3. a clinician erythema assessment (cea) score of greater than or equal to 3 at screening and at baseline/day 1 (prior to the study drug application). 4. a patient self assessment (psa) score of greater than or equal to 3 at screening and at baseline/day 1 (prior to the study drug application). key exclusion criteria: 1. particular forms of rosacea (rosacea conglobata, rosacea fulminans, isolated rhinophyma, isolated pustulosis of the chin) or other concomitant facial dermatoses that are similar to rosacea such as peri-oral dermatitis, demodicidosis, facial keratosis pilaris, seborrheic dermatitis, acute lupus erythematosus, or actinic telangiectasia. 2. presence of three (3) or more facial inflammatory lesions of rosacea. 3. current treatment with monoamine oxidase (mao) inhibitors, barbiturates, opiates, sedatives, systemic anesthetics, or alpha agonists. 4. less than 3 months stable dose treatment with tricyclic antidepressants, cardiac glycosides, beta blockers or other antihypertensive agents. 5. current diagnosis of raynaud's syndrome, thromboangiitis obliterans, orthostatic hypotension, severe cardiovascular disease, cerebral or coronary insufficiency, renal or hepatic impairment, scleroderma, sjögren's syndrome, or depression.

Keywords: rosacea
a study with peptide vaccination in treating patients with esophageal cancer

Conditions: Esophageal Cancer

Summary: the purpose of this study is to evaluate overall survival and immunological monitoring for peptide vaccination therapy using novel cancer testis antigens for locally advanced, recurrent, or metastatic esophageal squamous cell carcinoma (escc).

the phase i vaccination study using peptides derived from ttk, ly6k, and imp-3 for locally advanced, recurrent or metastatic esophageal squamous cell carcinoma (escc) who had failed for the standard therapy indicated that the vaccine treatment were well tolerated and feasible, and that antigen-specific t cell responses were strongly induced by the vaccination with some objective clinical responses. thus, we are currently initiating the randomized phase ii clinical vaccination study for the same cohort with escc to evaluate the survival benefit of the cancer vaccination.

Eligibility criteria:
inclusion criteria: disease characteristics * locally advanced, recurrent or metastatic esophageal squamous cell carcinoma who had failed for the standard therapy patients characteristics * ecog performance status 0-2 * age≧ 20≦ 80years * wbc≥ 2,000/mm³ platelet count ≥ 75,000/mm³ total bilirubin ≤ 2.0 x the institutional normal upper limits ast, alt, alp ≤ 2.5 x the institutional normal upper limits creatinine ≤ 1.5 x the institutional normal upper limits * no therapy 4 weeks prior to the initiation of the trial * able and willing to give valid written informed consent exclusion criteria: * pregnancy (women of childbearing potential: refusal or inability to use effective means of contraception) * breastfeeding * serious bleeding disorder * serious infections requiring antibiotics * concomitant treatment with steroids or immunosuppressing agent * decision of unsuitableness by principal investigator or physician-in-charge

Keywords: epitope peptide ctl esophageal cancer vaccination
multidisciplinary assesssment of structured report for cervical cancer staging

Conditions: Cervical Cancer

Summary: this study aims to validate a structured report for cervical cancer anchored to the figo staging system. a structured report is hypothesized to aid in uniformly applying figo staging, reducing staging discrepancies and improving patient care and outcomes. furthermore, we believe that the participation of the clinicians will improve the quality of the report to minimize the need for multidisciplinary team discussion


Eligibility criteria:
inclusion criteria: * age ≥18 years old; * overt biopsy-proven diagnosis of cervical cancer, at any stage; * signed written informed consent to personal data treatment for research purposes exclusion criteria: * age \<18 years old; * uncertain diagnosis of cervical cancer; * mri scan not according the standard acquisition protocol (esur guidelines); * patients candidate to non-standard treatments; * refusal to sign the written informed consent to personal data treatment for research purposes