Kornimate/medical-research-clean huggingface dataset:
the potential therapeutic effects of psychedelic, n, n-dimethyltryptamine (dmt), on alcohol use disorder (aud)

Conditions: Alcohol Use Disorder (AUD); Alcohol-Related Disorders; Alcohol Use

Summary: this proposed study is a double-blind, randomized, placebo-controlled, parallel-group, laboratory study to determine the effects of dmt, plus psychotherapy, on alcohol use disorder.

this study is a placebo-controlled, randomized, double blind, clinical trial to investigate the safety, tolerability and efficacy of the psychedelic dimethyltryptamine (dmt), in addition to a short course of psychotherapy, on alcohol use disorder (aud). the investigators hypothesize that relative to control (0.2 mg/kg/min + dimethyltryptamine 0.01mg/kg/min infusion plus psychotherapy), a single psychedelic dose of dmt (plus psychotherapy) in individuals with aud will 1) be safe and 2) well-tolerated, and 3) reduce alcohol consumption measured in the laboratory the day after, and over the following 8 weeks.

Eligibility criteria:
inclusion criteria: * diagnostic and statistical manual of mental disorders-5th edition (dsm-5) diagnosis of alcohol use disorder * medically healthy * ability to provide consent exclusion criteria: * unstable medical conditions
barriers to physical activity in familial mediterranean fever

Conditions: Familial Mediterranean Fever (FMF )

Summary: this project is a 2209-a tübi̇tak project. it has been developed to identify the barriers to physical activity among patients diagnosed with familial mediterranean fever (fmf). the project aims to determine the problems encountered by fmf patients when engaging in physical activity and the reasons behind these issues, using various assessment methods to identify the reasons for avoiding physical activity.

this project is a 2209-a tübi̇tak project. it has been developed to identify the barriers to physical activity among patients diagnosed with familial mediterranean fever (fmf) referred to the department of internal medicine, rheumatology division, at istanbul university-cerrahpaşa, cerrahpaşa medical faculty, as well as the faculty of health sciences, department of physiotherapy and rehabilitation. the project aims to determine the problems encountered by fmf patients when engaging in physical activity and the reasons behind these issues, using various assessment methods to identify the reasons for avoiding physical activity. patients diagnosed with fmf will be evaluated based on pain (mcgill melzack pain questionnaire), quality of life (fmf quality of life measure), fatigue status (fatigue severity scale), kinesiophobia (tampa scale for kinesiophobia), grip strength (digital hydraulic hand dynamometer), and aerobic capacity (spirometer). assessments will be conducted twice a week for three months, with each session lasting 30 minutes, utilizing the digital hydraulic hand dynamometer and spirometer under the supervision of researchers.

Eligibility criteria:
inclusion criteria: * diagnosis of familial mediterranean fever (fmf) * ability to respond to the questionnaires * capability to engage in physical activity exclusion criteria: * any form of disability (visual, auditory, mental, physical) * illiteracy in turkish * presence of comorbidities that may hinder assessment

Keywords: exercise physical activity
a comparison of early outcome of surgical management of proximal humerus fracture in adults during covid-19 pandemic- a prospective cohort study

Conditions: Proximal Humerus Surgery in Covid Recovered Patients

Summary: the goal of this observational study is to learn the outcome of proximal humerus fracture surgery in patients who had it delayed due to covid infection and compare it with normal patients with same fracture and treatment. the main question it aims to answer is: • do the patients with proximal humerus fracture undergoing delayed fixation secondary to covid infection have the same outcome as that of the normal patients? the outcome of patients of both group will be assessed objectively via the standard neer"s shoulder score and compared using independent variable t test.


Eligibility criteria:
inclusion criteria: * isolated traumatic proximal humerus fracture (neer's grading 3 and 4) * above 18 years of age * consenting for the study exclusion criteria: * open fractures: gustilo grade ii and iii * neurovascular compromise. * neuromuscular disorders. * injury severity score \>16 * humerus fracture with extension to shaft
comparing subsartorial saphenous nerve blocks with and without dexamethasone for anterior cruciate ligament reconstruction

Conditions: Anterior Cruciate Ligament Reconstruction; Regional Anesthesia, Saphenous Nerve Block

Summary: for patients undergoing anterior cruciate ligament reconstruction surgery, the postoperative period can be a painful experience without adequate pain management. hence the investigators propose a randomized controlled clinical study, investigating prolonged saphenous nerve blocks. patients will be randomized to receive saphenous nerve blocks with or without dexamethasone, a corticosteroid used to prolong analgesia. depending on the randomized treatment assignment, patients may receive one of the following: 1. 13 ml of 0.5% bupivacaine, a local anesthetic (no dexamethasone); 2. 13 ml of 0.5% bupivacaine mixed with 1 mg of dexamethasone; 3. 13 ml of 0.5% bupivacaine mixed with 4 mg of dexamethasone. patients will be followed postoperatively. following admission to the recovery room, data collectors will ask patients to rate their pain on a scale of 0-10 until discharge. data collectors will also record patient satisfaction, pain medication use and any side effects experienced (i.e. nausea and vomiting). patients will then be contacted on postoperative days 1, 2 and 14 and asked questions about their general well-being.


Eligibility criteria:
inclusion criteria: * patients undergoing ambulatory surgery for anterior cruciate ligament (acl) reconstruction with a patella tendon autograft. * asa i-iii \[american society of anesthesiologists (asa) physical status classification system\] * bmi \< 35 * smokers included * ages 16-65 exclusion criteria: * patients on steroids or requiring stress dose steroids * bmi \> 35 * patient refusal * allergy to study medications, * nrs scores \> 3 with frequent opioid use (including tramadol) prior to surgery-daily for greater than 3 weeks * lower extremity neurological dysfunction * diabetic (niddm, insulin-dependent and/or oral hypoglycemic dependent) * not in included age range (under 16 or over 65 years of age) * contraindications to the use of dexamethasone * non-english speaking patients. we will be using the short form 8 health survey, as well as the or-sds questionnaire (these are in english; any translations would have to be separately validated).

Keywords: dexamethasone glucocorticoids physiological effects of drugs therapeutic uses anterior cruciate ligament reconstruction regional anesthesia, nerve block ultrasonic imaging post-operative complications: muscle weakness, pain, nausea and vomiting dexamethasone (as local anesthetic additive)
recurrence rate after endoscopic resection of , laterally spreading tumor granular type (lst-g) of the colon and rectum: endoscopic mucosal resection vs. endoscopic submucosal dissection

Conditions: Colorectal Cancer

Summary: colorectal cancer is one of the leading causes of cancer-related mortality worldwide. early-stage non-polypoid neoplastic lesions, particularly laterally spreading tumors - granular type (lst-g) larger than 20mm, require effective endoscopic removal to prevent malignant progression. the two primary techniques for resecting these lesions are endoscopic mucosal resection (emr) and endoscopic submucosal dissection (esd). emr is a widely used, minimally invasive technique that involves resecting the lesion with a diathermic snare after submucosal injection. while effective and safe, emr often necessitates piecemeal resection, increasing the risk of local recurrence. in contrast, esd, developed in asia, allows for en bloc resection regardless of lesion size, ensuring more accurate histopathological assessment and lower recurrence rates. however, esd requires greater technical expertise, has longer procedural times, and carries a higher risk of complications. in western clinical practice, emr remains the standard treatment, whereas esd is selectively performed in high-expertise centers. given the lack of randomized controlled trials comparing emr and esd in western populations, this study aims to provide robust clinical evidence to guide treatment decisions. the primary objective of this study is to compare the recurrence/residual adenomatous tissue rate at 6 and 12 months between emr and esd in patients with lst-g lesions of the colon and rectum


Eligibility criteria:
inclusion criteria: * age ≥ 18 years. * diagnosis of laterally spreading tumor - granular type (lst-g) ≥ 20 mm in the colon or rectum with an indication for endoscopic resection. * life expectancy \> 10 years. * ability to understand and sign the informed consent form, demonstrating comprehension of the study and willingness to participate. exclusion criteria: * diagnosis of laterally spreading tumor - non-granular type (lst-ng). * presence of depressed areas within the lesion. * lesions located on a scar or anastomosis site. * lesions classified as kudo vi or vn pattern. * history of chronic inflammatory bowel disease (e.g., ulcerative colitis, crohn's disease). * diagnosis of hereditary polyposis syndromes (e.g., familial adenomatous polyposis, lynch syndrome).

Keywords: endoscopic mucosal resection (emr) endoscopic submucosal dissection (esd) laterally spreading tumors (lst)
repeatability in measurements of two ssoct and one olcr biometer

Conditions: Cataract Senile

Summary: achieving high accuracy and precision in ocular biometry has become primordial for cataract surgery, due to the shift of cataract surgery from a rehabilitation procedure to a refractive one. aim of this study is to determine the repeatability of ocular biometric parameters obtained using three biometry devices, two ss-oct biometers and an olcr device.

accurate and repeatable biometric measurements are essential in providing an optimal refractive outcome. ss-oct biometry uses a tunable wavelength laser source to scan the eye, this technology showing its superiority through better signal-to-noise ratio, the wavelength light source being projected into the eye, one at a time; thus improving tissue penetration. this a prospective observational study that would include patients which attended pre-surgical examination. a written informed consent will be obtained from each patient. only one eye from each patient will be included in the study. all patients included in the study will undergo biometric measurements in a random fashion with the three devices (iolmaster 700, lenstar ls 700 and anterion heildelberg). each patient will be measured three times with each device and between the measurements they will be asked to blink or keep their eyes closed for tear film recovery and to avoid fatigue. scans that pass the quality requirement of each device will be taken for analysis.

Eligibility criteria:
inclusion criteria: * 40 years old or above * age-related cataract exclusion criteria: * patients with dense cataract or corneal pathology that would significantly influence biometric measurements * nystagmus or pathologies that would affect patient fixation * pregnancy- for women in reproductive age a pregnancy test will be performed.

Keywords: ss-oct olcr biometry
adjuvant post-tamoxifen exemestane trial

Conditions: Breast Cancer

Summary: the atena phase iii randomized parallel-group multicenter trial is designed to compare 5 years of adjuvant exemestane versus 5 years of observation in postmenopausal women with operable breast cancer who have received 5-7 years of adjuvant tamoxifen. the primary endpoint for the core protocol is disease-free survival (dfs). exemestane treatment is planned for 5 years unless disease relapse or excessive toxicity is documented, the patient refuses further treatment or any new anti-cancer therapy is initiated.

* patients must have completed at least 5 years and not more than 7 years of continued treatment with tamoxifen (20 mg/day), while tamoxifen could have been discontinued up to 6 months prior to study entry. * a substudy (atena lipid substudy)is designed to evaluate changes in the patients' serum lipid profile during study treatment.

Eligibility criteria:
inclusion criteria: * postmenopausal women only * histologically confirmed stage i-iiia primary adenocarcinoma of the breast * estrogen and/or progesterone receptors positive or unknown * patients should have undergone surgery with a curative intent * patients must have completed at least 5 years and not more than 7 years of continued treatment with tamoxifen (20 mg/day), while tamoxifen could have been discontinued up to 6 months prior to study entry * absence of any evidence of local or distant metastatic disease was required prior to randomization exclusion criteria: * dcis, bilateral breast cancer, evidence of metastasis, er and pgr negative

Keywords: breast cancer aromatase inhibitors exemestane tamoxifen lipids
strict need to void after same-day discharge, non-urogynecologic, minimally invasive hysterectomy

Conditions: Urinary Retention Postoperative

Summary: patients who are undergoing non-urogynecologic, minimally invasive (laparoscopic, robotic) hysterectomy who are discharged the day of surgery will be randomized to a strict need to void versus no need to void prior to discharge. to determine if a strict versus liberal voiding trial following the aforementioned surgery in same day discharge patients increases rates of post-operative urinary retention, urinary tract infection (uti), or re-presentation and if there is a difference in post-anesthesia care unit (pacu) time and costs.


Eligibility criteria:
inclusion criteria: * women 18+ undergoing minimally invasive benign, non-urogynecologic hysterectomy * english speaking exclusion criteria: * at the surgeons discretion based on amount of bladder dissection the patient can be removed from the study at the conclusion of surgery * any patient with a history of prior urologic procedures * patients with any baseline known urinary disease * any bladder injury at the time of surgery * any combined cases with other surgical services * patients undergoing surgery for prolapse or incontinence symptoms * patients who are ultimately not discharged the same day and remain in house overnight

Keywords: minimally invasive hysterectomy urinary retention some day discharge
electroacupuncture for patients with chronic urinary retention secondary to lower motor neuron lesion

Conditions: Chronic Urinary Retention

Summary: chronic urinary retention (cur) is defined as a non-painful bladder which remains palpable or percussible after the patient has passed urine by international continence society. postvoid residual urine volume ≥300 ml seems to be widely accepted. cur may be caused by a variety of diseases and events including injury of sacral plexus, cauda equina and sacral spinal cord, pelvic floor nerve lesion after pelvic surgery and peripheral neuropathy due to diabetes, etc.. aforementioned injuries generally affect lower motor neuron causing detrusor underactivity, acontractile detrusor or detrusor areflexia. the prevalence varies by different causes of lower motor neuron lesion. the symptoms of patients are voiding difficulty, bladder distention, bladder without sensation and overflow incontinence. a multi-center randomized sham-controlled trial will be conducted. the aim of this study is to assess the efficacy and safety of electroacupuncture for urinary function of patients with cur caused by lower motor neuron lesion.


Eligibility criteria:
inclusion criteria: * have chronic urinary retention caused by lower motor neuron damage. * age 18 to 75 years. * have chronic urinary retention caused by injury of sacral plexus, cauda equina and sacral spinal cord, pelvic floor nerve lesion after pelvic surgery and peripheral neuropathy due to diabetes. * have postvoid residual urine volume 300 ml or more and sensation of bladder. * bladder contractile index is more than 100 or more. * duration of disease is more than 3 months. * intermittent clean catheterization or indwelling catheterization. * sign informed consent and participate in the study voluntarily. * exclusion criteria: * have urinary retention due to bladder outlet obstruction (bladder neck contracture, urethral stricture, prostate cancer, prostatic hyperplasia, etc.) * have urinary system tumors or stones. * have detrusor underactivity due to other non-lower motor neurogenic disease. * have bowel and urinary disorder due to lesions or injuries of thoracic spinal cord, cervical spinal cord and brain. * after suprapubic cystostomy. * have heart, liver, kidney, mental disorders or coagulation disorders. * have been implanted a cardiac pacemaker, sacral nerve stimulation electrode, pudendal nerve stimulation electrode, or bladder stimulation electrode. * during pregnancy or in lactation.

Keywords: chronic urinary retention electroacupuncture urinary function randomized controlled trial
mobile technology and motivational interviewing in type 2 diabetes patients

Conditions: Type 2 Diabetes Mellitus; Gaming; Motivational Interviewing; Self-Management; Quality of Life; Mobile Technology

Summary: type 2 diabetes patients were divided into experimental and control groups. patients in the control group received regular nursing care, while those in the experimental group received mi, which is empowered by game-based mobile technology. pre-test, post-test and follow-up test self-management, quality of life and satisfaction levels scores were determined.

a randomized controlled and experimental study design was used to conduct this research on 64 patients with type 2 dm. purpose of this study was to explore how motivational interviewing powered by game-based mobile technology affected self-management, quality of life, and satisfaction in type 2 diabetes patients.

Eligibility criteria:
inclusion criteria: * being 18 years or older, * having a diagnosis of type 2 diabetes mellitus according to the ada diagnostic criteria, * being on oral antidiabetic and/or insulin therapy, * having a smart phone and knowing how to use it, * internet connection (to install mobile technology application), * not having participated in motivational interviewing (mg) training before, * not having vision and hearing problems, * not having a communication problem, * to be able to read, write and speak turkish, * volunteering to participate in the study and continue the study process. exclusion criteria: * having a diagnosis of type 1 and/or gestational diabetes mellitus, * having serious health problems that prevent participation in motivational interviewing, * using steroid therapy, * having complications that may develop in the long term due to diabetes and having advanced retinopathy, neuropathy, amputation history or active foot wound, * having mental confusion, having any psychiatric problems and/or using a psychiatric drug, * being unwilling to participate in the study and/or not wanting to continue the study process.

Keywords: type 2 diabetes self-management quality of life satisfaction nursing mobile technology gaming motivational interviewing
pharmacist assisted medication program enhancing the regulation of diabetes

Conditions: Diabetes Mellitus, Type 2

Summary: the purpose of this study is to demonstrate that pharmacists working collaboratively with physicians and other providers in an ambulatory care setting can improve glucose, blood pressure, and lipid control, as well as improve quality of life, adherence to screening and general preventative measures.

it is evident that a multi-disciplinary approach is key to the success in controlling the disease of diabetes and its complications. the value of pharmacists' involvement in disease state management in producing positive outcomes for patients has been well documented in the literature. there have been several studies that have shown that pharmacists' involvement in diabetes care improves glycemic control. there are also studies that look at pharmacists' management of glycemic control and adherence to the ada guidelines. many of these studies are retrospective, lack a randomized control group, had a small study sample, or were short term. we undertook a prospective, randomized study to demonstrate that pharmacists working collaboratively with physicians and other providers in an ambulatory care setting can improve glucose, blood pressure, and lipid control, as well as improve quality of life, adherence to screening and general preventative measures.

Eligibility criteria:
inclusion criteria: * patients over the age of 18 * a1c \> 8% within the 6 months prior to the data acquisition date * primary care physician at lahey clinic burlington site * diagnosis of t2 dm for minimum of 6 months exclusion criteria: * concurrently enrolled in any other pharmacist-run or diabetes study * receiving diabetes management by an outside provider * a medical condition that may adversely affect compliance with the treatment protocol

Keywords: diabetes mellitus, type 2 pharmaceutical care collaborative practice
conventional and ultrasonic implant site preparation

Conditions: Bone Atrophy, Alveolar

Summary: multi center study with randomized controlled trial design, split mouth

the present study has been designed as a multicenter prospective randomized controlled trial design. fifteen clinical centers will treat patients by inserting and immediately loading implants with two different surgical protocols. each patient will receive two identical implants: after randomization, the test site will be prepared by ultrasonic microvibrations and the control site using twist drills. both implants will be loaded with a provisional crown within 48 hours after surgery. for each inserted implant, collection of experimental parameters will be required up to 2 years after surgery.

Eligibility criteria:
inclusion criteria: indications for two implant-supported single crowns with immediate loading in the upper or lower arch (in the incisor, canine or premolar area), based on accurate diagnosis and treatment planning; 2) implants can be in the same or in different quadrants; 3) implant sites must be performed in similar bone quality (i.e. both maxillary or mandibular); 4) the bone crest must be healed (at least three months elapsed after tooth loss); 5) presence of a residual bone crest with an adequate volume to allow the insertion of a 3.8x11.5 mm implant without any kind of regenerative procedure; 6) age of the patient \>18 years; 7) patient willing and fully capable to comply with the study protocol; 8) written informed consent given; exclusion criteria: 1. acute myocardial infarction within the past 2 months; 2. uncontrolled coagulation disorders; 3. uncontrolled diabetes (hba1c \> 7.5%); 4. radiotherapy to the head/neck district within the past 24 months; 5. immunocompromised patient (hiv infection or chemotherapy within the past 5 years); 6. present or past treatment with intravenous bisphosphonates; 7. psychological or psychiatric problems; 8. alcohol or drugs abuse local exclusion criterion is the presence of uncontrolled or untreated periodontal disease (full mouth plaque score and full mouth bleeding score \> 25%)

Keywords: implant piezoelectric drills immediate loading