Kornimate/medical-research-clean huggingface dataset:
effect of cognitive-behavioral strategies on nurses caring for children with autism spectrum disorder

Conditions: Nurses Behaviors

Summary: the purpose of this study is to determine if a structured training program in cognitive-behavioral strategies can improve: self-efficacy: the belief in one's ability to succeed in specific tasks or situations. sense of coherence: a perception of life as comprehensible, manageable, and meaningful. psychological ownership: a sense of possession or attachment to one's job or role. these outcomes are critical for nurses working with children with asd, as their role involves unique emotional and professional challenges. the study will use a rigorous scientific approach to assess the effectiveness of the intervention.


Eligibility criteria:
registered nurses who provide direct care to children with asd in settings such as hospitals, clinics, or specialized care centers. inclusion criteria: * at least 6 months of experience caring for children with asd. * currently employed in a direct caregiving role for these children. exclusion criteria: * nurses with prior formal training in cognitive-behavioral therapy. * nurses planning to leave their position during the study period.
relationship of interstitial cystitis to vulvodynia

Conditions: Interstitial Cystitis

Summary: this study is important in urologic nursing since many patients have interstitial cystitis (ic), a condition of frequency, urgency and pain affecting more than 1 million women in the united states. the vulva may actually be the site of some of the reported pain in women with ic, not the urethra or bladder. ic and vulvodynia can impact one's sexual functioning and diminish one's quality of life. the purpose of this two-part study is to identify and clinically confirm the presence of vulvodynia in women diagnosed with interstitial cystitis (ic).


Eligibility criteria:
inclusion criteria: * females who are 18 years of age and older. * diagnosis of interstitial cystitis

Keywords: pelvic pain vulvar pain
pilot study of pentoxifylline for hepatopulmonary syndrome

Conditions: Hepatopulmonary Syndrome

Summary: the hepatopulmonary syndrome (hps) results from intrapulmonary microvascular dilatation that impairs arterial oxygenation in the setting of cirrhosis or portal hypertension. as many as 10-20% of cirrhotics being evaluated for orthotopic liver transplantation (olt) have advanced hps and mortality is greater in those with hps than in those without hps. currently, olt is the only effective treatment, although post-operative mortality in hps is increased relative to cirrhotic patients without hps, with a one-year survival of between 68-80 %. therefore, an effective medical therapy for advanced hps could improve both pre-operative and post-operative mortality. recent work in experimental models of hps has revealed that both nitric oxide synthase-derived nitric oxide and heme oxygenase-derived carbon monoxide cause intrapulmonary vasodilatation. these alterations appear to be driven in part by tnf-α modulation of pulmonary blood flow and intravascular monocyte accumulation. pentoxifylline is a nonspecific phosphodiesterase inhibitor with inhibitory effects on tnf-α and has recently been shown to be beneficial in patients with severe alcoholic hepatitis where tnf-α overproduction contributes to liver injury. in experimental hps, pentoxifylline administration also decreases the severity of oxygenation abnormalities. however, pentoxifylline therapy has been associated with dose limiting side effects in patients with liver disease and the tolerability of pentoxifylline in cirrhotic patients with advanced hps is unknown. therefore, this open label single arm clinical trial was designed to evaluate the efficacy and tolerability of 8 weeks of pentoxifylline in cirrhotic patients with advanced hps being considered for olt.


Eligibility criteria:
inclusion criteria: * patient undergoing liver transplantation evaluation for cirrhosis * hps (positive contrast echocardiography, hypoxemia, no other cause) * pao2 \< 65mmhg * ability and willingness to give informed consent exclusion criteria: * patients under the age of 19 * active bacterial infections * known malignancy * intrinsic cardiopulmonary disease * known intolerance to pentoxifylline

Keywords: hypoxemia liver transplantation evaluation cirrhosis
non-invasive screening for fetal aneuploidy: a new maternal plasma marker

Conditions: Down Syndrome (Trisomy 21); Edwards Syndrome (Trisomy 18); Patau Syndrome (Trisomy 13); Turner Syndrome

Summary: validate that circulating cell free fetal nucleic acid can be used to identify a direct marker for fetal aneuploidy, particularly fetal down syndrome (ds), that is better than surrogate markers.


Eligibility criteria:
inclusion criteria: * subject is female * subject is pregnant * subject is high risk aneuploid patient undergoing genetic counseling, unltrasound screening, amniocentesis and/or cvs procedure * subject is willing to provide blood specimen exclusion criteria: * subject is not pregnant * subject is not willing to provide blood specimen * subject is not haveing aneuploid screening

Keywords: down syndrome
effects of functional motor control on pain, flexibility, lower extremity function with itbs

Conditions: Iliotibial Band Syndrome; Pain; Flexibility

Summary: the study is randomized and single-blinded. ethical approval is taken from ethical committee of riphah international university, lahore. participants who meet the inclusion criteria will be enrolled and allocated in group a \& b through sealed envelope method by non-probability convenient random sampling technique. subjects in group a will receive functional motor control exercises. group b will receive conventional exercises.

the objective of this study is to determine the effects of functional motor control exercises on pain, flexibility and lower limb functional. it will be randomized controlled trial (rct) research design at pakistan sports board through non probability convenience sampling technique on 72 runners' athletes which will be allocated using random sampling through computerized generated number into group a and group b, 36 athletes will be in each group. group a (interventional) will be given conventional training with functional motor exercise and group b (control) will be given conventional training. there will be 3 sessions in a week for 6 weeks. the baseline scoring will be on 1st day, follow up will be taken at 6th week. assessment will be made by numeric pain rating scale, lower extremity functional scale (lefs), single leg mini squat, y balance. data will be analyzed during spss software version 26. after assessing normality of data by shapiro-wilk test, it will be decided either parametric or non-parametric test will be used within a group or between two group

Eligibility criteria:
inclusion criteria: * male and female athlete within 19-40 years, * running a minimum average of 15 running kilometers, * runners with one sided iliotibial band syndrome for at least 3 months were included, * pain along it band at either gerdy's tubercle or the lateral femoral epicondyle during running, * positive stiffness with ober's test, and * reporting pain during noble's compression test. exclusion criteria: * individuals with a history of previous knee trauma of past 6 months, * individuals with a history of previous knee surgery of past 6 months, * other knee abnormalities including patellofemoral joint pain, * popliteus tendinitis, * lateral meniscal injury, * degenerative joint disease, and * lateral collateral ligament sprain to the affected side.

Keywords: motor control function excercise lower extermity function iliotibial band syndrome
effect of nursing care on prevention of dry eye

Conditions: Dry Eye Syndromes

Summary: clinical trial for prevention, randomized controlled, parallel, double-blind, with three arms, which purpose is verify the nursing interventions (artificial tear gel and liquid artificial tears)effects to prevent dry eye in adult patients admitted in icu.

critically ill patients are at higher risk for dry eye and the mechanisms responsible for ocular lubrication and protection can be compromised. however, the literature diverges on which is the best clinical practice for treatment. thus, the general objective of this study was to evaluate the risk for developing dry eye in critically ill patients and the effectiveness of three types of interventions: eye gel and eyedrops (control group). the specific objectives were: verify the most effective intervention for the prevention of dry eye from the available literature and provided by: eye gel compared to the control group eyedrops who received eye care through randomized controlled clinical trial. patients and methods: this study is a randomized controlled trial to determine the best care for the prevention of dry eye from those available on the market (eye drops and eye gel), in the period from 14/01/2016 to 31/12/2019 . the expected result is: negative values in schirmer test and no corneal ulcers presence.

Eligibility criteria:
inclusion criteria: * be over 18 years; * did not present dry eye at the time of admission; * stay in the icu for at least 24 hours; * be in mechanical ventilation therapy; * glance less than 5 per minute; * comatose, sedated or glasgow less than or equal to 7; * consent to participate in research or have. exclusion criteria: * have not the responsabille authorization; * patients with severe eye disease or with history of adverse effects after use of any of the interventions proposed and not tolerate the treatment: artificial tear gel, artificial tear liquid and saline 0.9%.

Keywords: dry eye diseases of the eye and adnexa
ayurvedic treatment package in plaque psoriasis

Conditions: Psoriasis

Summary: psoriasis is a chronic, immune-mediated inflammatory skin disease that is associated with substantial impairment of physical and psychological quality of life. the conventional treatment protocols manages the condition but with remissions and relapses which create anxiety in patients. many of the patients withdraw from active social life as the disease attains chronicity. several studies are pointing towards a conjoint management strategy incorporating the traditional and alternate medical systems. in this regard, ayurveda is commonly used by psoriatic patients in india. considering this fact it is high time to conduct a study to scientifically evaluate the efficacy of ayurvedic treatment protocol in managing psoriasis as well as its potential to improve the quality of life.


Eligibility criteria:
inclusion criteria: * patients with psoriasis having age 18 years or more * patients with moderate-to-severe plaque psoriasis with a pasi score of 12 or higher * psoriasis diagnosed 6 months or more before study entry * those who are poorly controlled based on physicians assessment with topical treatments, phototherapy, systemic therapy, or a combination of these therapies. * participants who have given informed consent. exclusion criteria: * participants with other systemic illnesses * lactating and pregnant mothers. * alcohol dependence/narcotic dependence /steroid dependence * in the judgment of the investigator, unable or unwilling to follow the protocol and instructions
treatment for obesity and binge eating disorder

Conditions: Binge Eating Disorder; Obesity

Summary: this study is a test of cognitive behavioral therapy(cbt) and behavioral weight loss (bwl) treatments for obese patients with binge eating disorder (bed). the study involves a comparison of three treatment conditions: (1) cbt; (2) bwl, and (3) a sequential (two-part) treatment consisting of cbt followed by bwl.


Eligibility criteria:
inclusion criteria: * binge eating * overweight exclusion criteria: * pregnancy * current cardiac disease * serious neurologic illnesses

Keywords: binge eating disorder cognitive behavior therapy combination therapy obesity weight loss body weight clinical trial dietary restriction overeating weight control
relative energy deficiency in rowers

Conditions: Endothelial Dysfunction; Mood Disorders; Malnutrition, Calorie

Summary: this study aims to learn about relative energy deficiency in male and female rowers at the end of the direct sport preparation phase of the annual training cycle. the main questions: - how will energy intake influence leptin, cortisol levels, mood, gut discomfort, and permeability? the observational study involves male and female rowers from the polish rowing team. participants will perform 2000 meter ergometer test and 6000 ergometer test in annual training cycle. researchers will compare outcomes from both tests.


Eligibility criteria:
inclusion criteria: * membership in polish rowing team, * minimum five years of training, * total training time minimum of 240 minutes, * filling out a food diary, * finishing 2000-meter ergometer test. exclusion criteria: * probiotics within the last three months, * prebiotics within the last three months * antibiotic therapy within the last three months, * dietary regime, * gastrointestinal diseases.

Keywords: relative energy deficiency gut permeability rowers
a study to evaluate the use of nitazoxanide to treat cryptosporidiosis

Conditions: Cryptosporidiosis; HIV Infections

Summary: the purpose of this study is to see if nitazoxanide (ntz) can be used to treat aids patients suffering from cryptosporidiosis (diarrhea caused by the parasite cryptosporidium).

patients receive oral nitazoxanide daily for 14 days, after which those with complete clinical and parasitologic response discontinue treatment. non-responders and partial responders may continue therapy for an additional 14 days at the discretion of the physician. non-responders who show signs of improvement or who have partial response after 28 days and those who relapse following complete response may continue therapy for an additional month, up to 60 days total. \[as per amendment 10/30/96: patients receive a daily treatment for 4 weeks, with subsequent dose escalation in the absence of drug-related toxicity. patients who exhibit complete response after 2 months may continue at a maintenance dose. patients enrolled after october 15, 1996 are randomized to 1 of 2 doses, with subsequent escalations made in the absence of toxicity. complete responders may continue therapy at a maintenance dose and duration determined by the investigator. non-responders after 6 months of therapy have treatment discontinued.\] \[as per amendment 8/5/97: all patients are evaluated at weeks 1, 2, 4, and monthly thereafter.\] \[as per amendment 8/17/99: new patients start therapy on a different dosage of nitazoxanide. those who do not respond after 4 weeks of therapy will escalate to a higher dosage. patients who show a complete response at 2 consecutive visits (2 weeks apart) discontinue nitazoxanide therapy and go to follow-up.\] \[as per amendment 2/3/00: the week 1 clinical evaluation is deleted from the study procedures.\]

Eligibility criteria:
inclusion criteria patients may be eligible for this study if they: * are 3 to 65 years old (need consent of parent or guardian if under 18). * have aids. * have a cd4 count less than or equal to 200 cells/mm3. (note: patients with a cd4 count greater than 200 cells/mm3 but who have had cryptosporidiosis for at least 4 weeks may be eligible for this study.) * test positive for the parasite cryptosporidium and have severe diarrhea (at least 4 bowel movements per day) for at least 2 weeks. * have received treatment for cryptosporidiosis but have become reinfected after treatment. * agree to practice abstinence or use effective methods of birth control (such as a condom) before and during the study. exclusion criteria patients will not be eligible for this study if they: * are pregnant. * are infected with certain other parasites. * have a history of certain intestinal diseases. * have received certain medications.

Keywords: cryptosporidiosis diarrhea acquired immunodeficiency syndrome nitazoxanide antiparasitic agents
oral testosterone for the treatment of hypogonadism in males

Conditions: Hypogonadism

Summary: low testosterone is a condition that occurs when the body is unable to produce sufficient quantities of testosterone. the medical name for low testosterone is hypogonadism. hypogonadism can be caused by many factors. symptoms include: decrease in libido, lack of energy and mood swings. the goal of testosterone replacement therapy is to return testosterone levels to the normal range and relieve symptoms.

the purpose of this study is to evaluate the pharmacokinetic (pk) parameters of testosterone after administration of tsx-002 (easy to swallow testosterone capsules) to hypogonadal men. this will be determined by blood sampling at specified times during the study. the study is also intended to evaluate the pk parameters of the testosterone metabolite, dihydrotestosterone (dht), as well as the safety and tolerability of tsx-002. the study consists of three (3) periods, for which tsx-002 will be taken orally at various doses. study duration is approximately 9 weeks.

Eligibility criteria:
inclusion criteria: * symptomatic hypogonadal male subjects (testosterone \> 100 and \<300 ng/dl, two separate 10 am samples one week apart), * 18-70 years old, * willing and able to provide informed consent and to participate in all 3 periods of the study. * bmi \< 35 kg/m2. exclusion criteria: * malabsorption conditions (e.g. history of cholecystectomy, inflammatory bowel disease, pancreatitis, celiac disease, sprue, dumping syndrome, bariatric surgery; short bowel syndrome, lactose intolerance); * alcoholics or substance abuse; * gastroparesis; ipss (international prostate symptom score) \> 19; psa (prostate-specific antigen)\> 4 ng/ml; * congestive heart failure, uncontrolled (nyhc \>1); * uncontrolled sleep apnea; * topical or injectable testosterone replacement therapy (any kind including dehydroepiandrosterone (dhea) and nutritional supplements) within past 4 weeks; * testopel excluded if within 2 years; * aveed excluded if within past 6 months; * hematocrit \> 50.

Keywords: hypogonadism gonadal disorders endocrine system diseases testosterone testosterone enanthate testosterone undecanoate testosterone 17 beta-cypionate methyltestosterone androgens hormones hormones, hormone substitutes, hormone antagonists physiological effects of drugs pharmacologic actions therapeutic uses anabolic agents dihydrotestosterone
sensory mapping and thermal thresholds after thoracic surgery

Conditions: Lung Cancer

Summary: the study will investigate topography of sensory changes late after lung cancer surgery


Eligibility criteria:
inclusion criteria: * understand danish * age \> 18 years old * ptps exclusion criteria: * cognitive dysfunction * repeated thoracic surgery * nerve injury from other causes * drug or alcohol abuse

Keywords: persistent pain neuropathic pain thoracotomy chronic pain
assessment of the clinical condition and way of nutrition patients before and after sleeve gastrectomy

Conditions: Obesity

Summary: conservative treatment of patients with morbid obesity is inefficient, which is why surgical treatment is necessary. although bariatric treatment is associated with the occurrence of complications resulting from the procedure or from nutritional insufficiencies, it leads to significant body mass reduction and metabolic improvement of obese patients. the aim of the study was to determine the clinical condition of obese patients after laparoscopic sleeve gastrectomy ( lsg) in terms of nutritional status, metabolic disorders and way of nutrition. the study conduced 4 visits: preliminary visit (1 day before the surgery) and control visits (1, 3 and 6 months after the surgery). based on the inclusion and exclusion criteria the observational study was conducted among 30 participants (15 women and 15 men).


Eligibility criteria:
inclusion criteria * women and men aged 18-64 * bmi ≥ 40 kg/m2 or bmi ≥ 35 kg/m2 with comorbidities such as type ii diabetes (t2dm), hypertension, sleep apnea and other respiratory disorders, non-alcoholic fatty liver disease, osteoarthritis, lipid abnormalities, gastrointestinal disorders, or heart disease exclusion criteria: * pregnancy * gastrointestinal cancers * cardiorespiratory failure

Keywords: bariatric surgery nutrition body composition nutritional status obesity laparoscopic sleeve gastrectomy
lymphovenous bypass manage venous leg ulcers

Conditions: Venous Leg Ulcer; Lymphovenous Edema

Summary: leg ulcers are areas of epidermal discontinuity in lower limbs with causes of venous, arterial, diabetic, pressure, traumatic, allergic, or inflammation. chronic venous leg ulcers (vlus) are defined as leg ulcers persisting for 4 weeks or more, a.k.a c6 in ceap classification of chronic venous insufficiency (cvi) and account for up to 70% of all chronic leg ulcers exhibiting overall prevalence of up to 2% in the general population of western countries with significant morbidity and a negative socioeconomic impact. wound care, debridement, bed rest with leg elevation, and compression are basic approaches for chronic vlus. meanwhile, numerous medical and surgical interventions were developed to promote wound healing and to prevent recurrence by focusing on pathophysiology of chronic vlus. however, many strategies just have adjuvant effects or exert debatable benefits. the lymphatic system been considered important for removal of excessive fluid from the interstitial space, absorption of fat from the intestine and the immune system, actively involved in regulation of immune cell trafficking and inflammation. emerging lymphovenous bypass (lvb), a supermicrosurgical technique diverting lymphatic drainage into venous system in dealing with lymphedema, not only restores th1 and th2 imbalance, but decreases oxidative stress and increases antioxidant capacity in the serum of lymphedema patients. clinically, lvb could be an alternative treatment option for patients with lymphorrhea. based on these facts, the investigators hypothesis that lymphatic hypertension and lymph impregnation contributes chronic venous leg ulcer formation and propose a novel strategy, using lvb to treat patients with refractory/recurrent chronic vlus. the preliminary results revealed promising results and the investigators would go on clinical trials.


Eligibility criteria:
inclusion criteria: * age: 20\~80 years * gender: all * poor wound healing after standard wound management for 4 weeks * deep vein thrombosis (dvt) has been ruled out by duplex and computer tomography or dvt has been treated * wound care with nursing specialty * recognize and agree to join this trial exclusion criteria: * autoimmune status, such as systemic lupus erythematosus * heart, lung, kidney or liver failure patients * radiation related wound or cancer wound * those who cannot understand the trial * age less than 20 years or elder than 80 years * pregnancy * those who was risky to receive general anesthesia or surgery * allergy to patent blue v or gentian violet

Keywords: chronic venous insufficiency lymphovenous bypass