Kornimate/medical-research-clean huggingface dataset:
impact of disease activity and nutrition treat on postoperative recurrence and complications after bowel resection for crohn's disease

Conditions: Crohn's Disease

Summary: the study was aimed to determine whether perioperative nutrition treat and(or)the perioperative disease activity were associated with postoperative recurrence and complications after bowel resection for crohn's disease.

the investigators want to assess the impact of possible risk factors on intestinal resection and postoperative recurrence in crohn's disease (cd) and to evaluate the disease course. in our clinical treatments, the investigators found that perioperative cdai and nutrition treatment may have same impact on postoperative recurrence and complication in crohn's disease. the investigators design this study to test it. the study prepare to collect the clinical data of patients who need bowel resection for cd to analyzed. the investigators divide those patients into two groups (n,i group). they accept intestinal nutrition with the respective aim that get the inflammatory index (erythrocyte sedimentation rate (esr), c-reactive protein (crp), crohns disease activity index (cdai)) norm or nutritional index norm before they accept surgery. postoperative recurrence and complications in patients will be recorded and compared.

Eligibility criteria:
inclusion criteria: patients had a crp level of more than 8mg/l patients had a preoperative weight loss \>5% over the past 6 months and had a serum albumin of less than 35g/l at the enrollment

Keywords: crohn's disease nutrition bowel resection postoperative recurrence complication active disease
rehabilitation exercise and education of airway clearance technique in ntm-pd: a prospective cohort study

Conditions: Nontuberculous Mycobacterial Pulmonary Disease

Summary: * the goal of this observational study is to evaluate the effects of pulmonary rehabilitation and airway clearance education in adults with nontuberculous mycobacterial pulmonary disease (ntm-pd). the main questions it aims to answer are: * does pulmonary rehabilitation and airway clearance training improve lung function, symptom relief, and quality of life in patients with ntm-pd? * does this non-pharmacological intervention contribute to better sputum culture conversion rates? * participants will: * undergo pulmonary rehabilitation and airway clearance training over an 8-week period (biweekly sessions). * receive evaluations at baseline, during the intervention, and follow-up assessments at 2 months, 6 months, and final study visit. * undergo tests including pulmonary function tests (pft), symptom assessments, bacteriologic evaluations, radiographic imaging (ct/x-ray), and quality of life surveys (eq-5d-5l, cat score). * this study aims to provide clinical evidence supporting the role of non-pharmacological treatments in the management of ntm-pd, potentially informing future treatment guidelines and improving patient outcomes.


Eligibility criteria:
inclusion criteria: * age 20 years or older at the time of enrollment. * diagnosis of nontuberculous mycobacterial pulmonary disease (ntm-pd) according to the 2020 american thoracic society (ats) guidelines. * identification of clinically significant ntm species, including: mycobacterium avium / mycobacterium intracellulare / mycobacterium abscessus / mycobacterium massiliense / mycobacterium kansasii / * able to undergo pulmonary rehabilitation and airway clearance training as part of the study protocol. * willing to provide written informed consent to participate in the study. exclusion criteria: * currently pregnant or actively breastfeeding. * unable to participate in pulmonary rehabilitation due to severe mobility impairment or neuromuscular disorders. * history of massive hemoptysis or other medical conditions where airway clearance techniques may be contraindicated.
single superior ilm/erm flap for the ftmh.

Conditions: Ophthalmopathy

Summary: in this study, the investigators will make the only upper flap either from the internal limiting membrane or from the epiretinal membrane to cover the full thickness macular hole.

after the investigators completed the clinical trial nct05269563, which was a double flap technique; that consists of two flaps from the internal limiting membrane and the epiretinal membrane. the inferior flap was implanted inside the hole, but the upper flap was utilized to cover the hole. the results were encouraging. therefore, in this study, the investigators will make the only upper flap to cover the full thickness macular hole, to compare both visual and anatomical outcomes with the double flapped technique (nct05269563) results. therefore the double flap will be our control.

Eligibility criteria:
inclusion criteria: * full thickness macular hole exclusion criteria: * lamellar and pseudo holes

Keywords: full thickness macular hole epiretinal membrane internal limiting membrane flap
platform for medical information extraction from incomplete data

Conditions: Liver Cancer

Summary: in order to perform research smoothly, the process of information extraction is required for translating data in clinical text into available format for analysis and statistic. in medical research, the problem of missing data occurs frequently. it is important to develop the method with better imputation performance in the stability and accuracy. the purposes of this project are to provide the data integration and extraction methods for handling the structured and unstructured data sources in more efficient ways, to provide the validation scheme for facilitating the data reviewing of extracted results produced by information extraction modules, to increase the quality of clinical data by comparing the data from different data sources and correcting data errors and inconsistent, to handle the clinical data with the properties of time series and incompleteness, to increase accuracy of data analysis and increase quality of health care by improving the completeness and correctness of clinical data, to provide flexibility of methods in the platform. in the project, the disease topic is focused on the liver cancer patients' clinical data and we hope the methods in the projects can be extended to handle other diseases by replacing these knowledge models in the future.

because of the increasing adoption of electronic medical record (emr) systems, the data access of emr is more and more convenient. however, there still have difficulties in analyzing all the clinical data directly due to a large number of records using the narrative format. in order to perform research smoothly, the process of information extraction is required for translating data in clinical text into available format for analysis and statistic. in medical research, the problem of missing data occurs frequently. it is important to develop the method with better imputation performance in the stability and accuracy. the purposes of this project are to provide the data integration and extraction methods for handling the structured and unstructured data sources in more efficient ways, to provide the validation scheme for facilitating the data reviewing of extracted results produced by information extraction modules, to increase the quality of clinical data by comparing the data from different data sources and correcting data errors and inconsistent, to handle the clinical data with the properties of time series and incompleteness, to increase accuracy of data analysis and increase quality of health care by improving the completeness and correctness of clinical data, to provide flexibility of methods in the platform. in the project, the disease topic is focused on the liver cancer patients' clinical data and we hope the methods in the projects can be extended to handle other diseases by replacing these knowledge models in the future.

Eligibility criteria:
patients with liver cancer

Keywords: clinical narrative report time series data missing value
developing accessible mhealth programs for depression management in bolivia

Conditions: Depression

Summary: the purpose of the study is to evaluate the feasibility and potential impact of an automated phone system in monitoring and improving self-care and health outcomes among patients with depression in bolivia.

all patients will receive a weekly 10-15 minute automated phone call to their cell phone for disease assessment and self-care support for up to 12 weeks. during enrollment, the research team will explain how to use the automated phone system. during patients' automated calls, they will be asked questions about their self-care relevant to their diagnosis, symptoms of depression, and medication adherence (if patients are prescribed an anti-depressant). based on the patient's self-report, they will receive targeted suggestions for how to improve their self-management. at the end of each automated call, patients will hear the phone number of their clinic, which they can call for a health problem or to disenroll from the program. at the time of recruitment, if possible, an initial automated call will be sent to the patient's phone so that they can learn what to expect and have the chance to ask questions of the research associate who will be present. in the event that the patient reports a health or self-care problem during their call (i.e., the patient reports rarely or never taking their medication), a report will automatically be generated and sent by email to the research team plus the patient's designated clinician so that follow-up can take place. the secure email address will be verified with each clinician, and be password protected. the intervention will last up to 12 weeks, after which the patient will have a follow-up meeting with the research team and will complete a survey about the program. all follow-ups will take place either in person or over the phone.

Eligibility criteria:
inclusion criteria: * 21-80 years of age * phq-8 score of 10 or higher exclusion criteria: * have diagnoses indicating a six-month life expectancy * prior inpatient psychiatric treatment * patients with probable bipolar disorder or cognitive impairment as indicated on validated screeners

Keywords: depression mhealth interactive voice response bolivia mental health
dienogest for treatment of adenomyotic uteri

Conditions: Adenomyosis

Summary: adenomyosis is a common disease in women aged 40-50 years. it associates with dysmenorrhea and menorrhagia. hysterectomy was considered the main treatment that could definitively cure this disease. other treatment options are increasingly offered, including hormonal suppression with gonadotropin-releasing hormone agonists or danazol and endometrial ablation. however, deep adenomyosis responds weakly to the above treatment options, which are commonly not considered for long-term management because of the associated side effects. dienogest is a progestin medication which is used in birth control pills and in the treatment of endometriosis and adenomyosis. low-dose combined oral contraceptive (coc) pills have been widely used as the primary treatment for menorrhagia. cocs can also be used to induce endometrial atrophy and to decrease endometrial prostaglandin production, which can consequently improve menorrhagia and dysmenorrhea that are associated with adenomyosis


Eligibility criteria:
inclusion criteria: * women aged 20-40 years * women with ultrasonographic evidence of adenomyosis * woman complains of vaginal bleeding or pelvic pain related to adenomyosis exclusion criteria: * women with a history of malignancy or histological evidence of endometrial hyperplasia * any adnexal abnormality on ultrasound * undiagnosed vaginal * contraindication to receive vissane or gynera .
optimizing adherence and glycemia in youth with new insulin-dependent diabetes mellitus (iddm)

Conditions: Type 1 Diabetes Mellitus

Summary: this 2-year randomized, controlled trial examined the impact of a clinic-based, family teamwork intervention on glycemic control in youth with recently diagnosed type 1 diabetes.


Eligibility criteria:
inclusion criteria: * 8 to 17 years old * duration of type 1 diabetes between 2 months and 6 years * residence in new england or new york * at least 1 outpatient visit in the past year exclusion criteria: * major co-morbid psychiatric or medical illness in youth * diagnosis of an active major psychiatric disorder in either parent * diagnosis of a life-threatening medical illness in either parent

Keywords: type 1 diabetes glycemic control family conflict quality of life parental involvement
radiofrequency non-ablation in the treatment of women with urinary stress incontinence: study pilot

Conditions: Urinary Incontinence

Summary: pilot study, case series conducted in women with a clinical diagnosis of urinary incontinence and were treated with radiofrequency technique for capacitive transfer non ablative in external urethral meatus. all participants did an hour pad test. the participants made five sessions of radio frequency (rf) with an interval of seven days between them. the application of rf was performed by physical therapist trained in the technique of radio frequency through the tonederm® brand device with capacitive transfer method using non-ablative handle with electrode in the region of the external urethral meatro and coupling electrode placed on the participant's back. for application, the participants were in gynecological position. the session had an average duration of 20 minutes. the temperature was measured by an infrared thermometer when it reached 41graus radiofrequency was maintained for 2 minutes.


Eligibility criteria:
inclusion criteria: * the target audience was made up of women aged between 18 and 65 years with a diagnosis of stress urinary incontinence, referred for physical therapy and who had pad test positive criteria by international continence society exclusion criteria: * were excluded from the study participants with limited understanding, with neurological degenerative chronic diseases, sensory deficit in the genital region, users of pacemaker and intrauterine device of copper and pregnant women

Keywords: urinary incontinence woman radiofrequency
non-helium magnetoencephalography in pediatric brain tumors

Conditions: Pediatric Brain Tumor

Summary: this observational study aims to evaluate the effectiveness of magnetoencephalography (meg) in the preoperative assessment of pediatric brain tumors, particularly in determining the extent of resection, and compare it with computed tomography (ct) and magnetic resonance imaging (mri). the main questions this study aims to answer are: what is the consistency between meg and ct/mri in localizing pediatric brain tumors? what is the clinical efficacy of meg in determining the extent of resection of pediatric brain tumors preoperatively? participants will: undergo both meg and ct/mri examinations for preoperative assessment, and the extent of tumor resection will be determined by the comprehensive results of the above examinations. be followed up with meg and ct/mri at 1, 3, and 6 months after surgery, along with neurological and quality-of-life assessments.


Eligibility criteria:
inclusion criteria: * age range: 3-18 years old; * clinically diagnosed with brain tumor; * capable of cooperating with magnetoencephalography evaluation and recording. exclusion criteria: * patients with serious comorbidities or neurological or psychiatric disorders that affect magnetoencephalography examination. * patients using drugs that affect central nervous system function; * patients who are not suitable for surgical procedures; * patients with progressive neurological disorders.

Keywords: magnetoencephalography pediatric brain tumor
non-sedation versus sedation with a daily wake-up trial in critically ill patients receiving mechanical ventilation - effects on physical function

Conditions: Critically Ill; Muscular Atrophy

Summary: critically ill, ventilator-treated patients rapidly loose much of their muscle mass and strength. this can attribute to prolonged admission, prolonged mechanical ventilation, increased mortality and might have a negative impact on the physical function, degree of independence and quality of life. the pathophysiological background for the loss of muscle mass as well as possible effective treatment is still not well established. in the nonseda-trial we randomise critically ill patients to non-sedation or sedation with a daily wake-up trial during mechanical ventilation in the intensive care unit (icu). it has never been assessed whether non-sedation reduces the loss of muscle mass and strength. aim: to assess the effects of non-sedation versus sedation with a daily wake-up trial on physical function after discharge from icu. hypothesis: that non-sedation during ventilator-treatment will improve the physical function after icu-discharge, compared with standard treatment of sedation with a daily wake-up.


Eligibility criteria:
inclusion criteria: * endotracheally intubated * expected time on ventilator \> 24 hours * age ≥ 18 years * informed consent exclusion criteria: * severe head trauma where therapeutic coma is indicated * therapeutic hypothermia where therapeutic coma is indicated * status epilepticus where therapeutic coma is indicated * patient has participated in the study before * patient is transferred from another icu with length of stay \> 48 hours * patient is comatose at admission * pao2/fio2 ≤ 9, if sedation is necessary for oxygenation

Keywords: non-sedation
application of ngs technique in precise diagnosis of infectious diseases

Conditions: Next Generation Sequencing; Infectious Disease

Summary: infectious disease leads to deaths that accounted for more than 25% of all causes of human mortality. but the traditional microbiological diagnostic methods such as specimen culture are sometimes time-consuming, and have limited sensitivity. and some bacteria, anaerobes and viruses may be difficult to cultivate and isolation. therefore, the accurate identification and rapid classification of pathogenic microorganisms is very important for the patient's precise diagnosis and timely treatment. small-scale studies on the diagnostic efficacy and prognosis of infection in the next generation have been shown to provide early diagnosis and targeted medication guidance for bloodstream infections and respiratory infections, but the larger-scale validation of next-generation sequencing technology in the diagnosis and treatment of infectious diseases in the human body is relatively rare. the purpose of this study is to provide rapid etiological diagnosis of patients by means of next-generation sequencing, to change the way of treatment of patients under the existing traditional pathogen detection by means of accurate description of pathogens and monitoring their dynamic changes, and to provide patients with more accurate treatment.


Eligibility criteria:
inclusion criteria: * patients are highly suspected of fever of unknown origin * patients are highly suspected of bloodstream infection * patients are highly suspected of respiratory infections * patients are highly suspected of central nervous system infection exclusion criteria: * patients diagnosed as non-infectious diseases such as cancer and autoimmune diseases;
electrical impedance tomography for optimization of positive end-expiratory pressure: acute respiratory distress syndrome

Conditions: Acute Respiratory Distress Syndrome; ARDS

Summary: doctors follow a standard ventilator management strategy when making adjustments to the breathing machine to optimize the amount of oxygen into the lungs. the purpose of this study is to assess whether the eit (electrical impedance tomography) device can be an additional useful tool for ventilator management and identifying the ideal positive end-expiratory pressure (peep).


Eligibility criteria:
inclusion criteria: * endotracheal ventilation for \< 1 week (168 hours) * presence of all of the following conditions for \ 5 cm water for \> 30 min. ii. bilateral opacities not fully explained by effusions, lobar/lung collapse, or nodules iii. respiratory failure not fully explained by cardiac failure or fluid overload -all criteria listed in (3) developed within 1 week of a known clinical insult or new or worsening respiratory symptoms exclusion criteria: * lack of informed consent * known pregnancy * extracorporeal membrane oxygenation (ecmo) use * severe chronic respiratory disease requiring home oxygen therapy or ventilation * calculated bmi of greater than 50

Keywords: electrical impedance tomography ventilator lung respiration
assessing the effectiveness of a preoperative high intensity interval training programme in older colorectal cancer patients

Conditions: Preoperative Care; Colorectal Neoplasms; Aged; Exercise

Summary: the primary aim of this study is to determine whether an improvement in aerobic fitness, as judged by an increase in vo2peak, can be achieved within 31 days via hit programme in a group of older, colorectal cancer patients.

12 high intensity interval training exercise sessions on a static cycle ergometer, over a period of 31 days. each session lasts 18 minutes. at the beginning and end of the study the following measures will be used to assess change in fitness, body composition and muscle metabolism. dxa scan, uss of thigh, vo2 peak cycling test, short performance battery tests, quality of life questionnaires and muscle biopsy.

Eligibility criteria:
inclusion criteria: * confirmed colorectal cancer * offered curative treatment by the royal derby hospital nhs foundation trust colorectal cancer multidisciplinary team * male and female * 18-88 years of age exclusion criteria: * uncontrolled hypertension (bp \> 160/100), * angina, * heart failure (class iii/iv), * cardiac arrthymias, * right to left cardiac shunt, * recent cardiac event, * previous stroke/tia, * aneurysm (large vessel or intracranial), * severe respiratory disease including pulmonary hypertension, * copd/asthma with an fev1 less than 1.5 l, * coagulation disorders, * scarring disorders. * current neoadjuvant chemo/radiotherapy * inability to complete the consent process involvement in invasive research study in previous 3 months.
development and implementation of evidence-based family-oriented support for young carers and their families in germany

Conditions: Chronic Illness

Summary: the purpose of this study is to develop and implement evidence-based and family-oriented support for young carers and their families in germany. hypothesis is that families' own support mechanisms, combined with externally provided support that is determined by the families' specific needs, will help to overcome their burden and enable families to live in the way they wish to despite chronic illness. this will lead to a measurable increase in hrqol of children concerned.


Eligibility criteria:
inclusion criteria: * children of mentally ill parents (chronic illness) * children of somatically ill parents (chronic illness) exclusion criteria: * children of drug addicted parents

Keywords: young carers family support children (up to the age of 18) of chronically ill parents