Kornimate/medical-research-clean huggingface dataset:
hyaluronic acid treatment of the post-extraction tooth socket healing in subjects with diabetes mellitus type 2

Conditions: Diabetes Mellitus, Type 2; Delayed Wound Healing; Tooth Extraction Status Nos

Summary: the aim of the present split-mouth study was to investigate the effect of hyaluronic acid (ha) in improving the post-extraction tooth socket healing in subjects with diabetes mellitus type 2. the null hypothesis was that ha can significantly improve the post extractive healing of diabetic patients compared with no treatment. 36 patients with diabetes mellitus type 2 requiring bilateral extraction of the homologous, not included, teeth were enrolled. after the extractions carried out in the same appointment, following the split-mouth design of the study, one site was randomly assigned to the test (t) group, while the other one was assigned to the control group (c). t group included: post-operative application of hyaluronic acid gels 3 times per day c group included: no treatment. patients were then followed after 3, 7,14 and 21 days and the healing of each socket was evaluated and compared between the 2 groups.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years old * diabetic type 2 patients with glycaemia levels under control but with a positive history for diabetes complications (e.g., nephropathy, neuropathy, retinopathy, cardiopathy, peripheral vascular disease) * agreement to be enrolled in the study * availability to come at the control visit exclusion criteria: * presence of platelet dysfunction * presence of thrombocytopenia * corticosteroid treatment * smokers * refusal to participate in the study * assumption of drugs possibly interacting with the wound healing * extractions requiring the elevation of a flap
dxr stent(previous cilotax) implantation registry

Conditions: Coronary Artery Diseases

Summary: registry of cilotax stent(dual drug eluting stent) implantation for cad patients


Eligibility criteria:
inclusion criteria: * patients with significant coronary artery disease and receiving cilotax (dual drug eluting stent) * the patient or guardian agrees to the study protocol and the schedule of clinical follow-up, and provides informed, written consent, as approved by the appropriate institutional review board/ethics committee of the respective clinical site exclusion criteria: * patients with a mixture of other dess * terminal illness with life expectancy \<1 year * patients presented with cardiogenic shock
interferon-alpha lozenges for prevention of relapse in hepatitis c

Conditions: Hepatitis C, Chronic

Summary: the purpose of this study is to determine whether lozenges of interferon-alpha that are dissolved in the mouth can prevent relapse in patients with hepatitis c virus infection who had a complete virologic response after receiving a combination of injected interferon-alpha and oral ribavirin.


Eligibility criteria:
inclusion criteria: * hcv genotype 1b * will be completing pegylated ifn-alpha and ribavirin therapy within 4 weeks * serum hcv rna negative within 4 weeks of study entry exclusion criteria: * child-pugh score of b or c * decompensated liver function * history of malignancy within past 5 years * other causes of liver disease besides hcv infection * uncontrolled diabetes or hypertension * unwilling to use two forms of birth control during study treatment

Keywords: prevention of relapse hcv genotype 1b recurrence
emdr in spider phobia: work mechanisms and treatment outcome

Conditions: Spider Phobia

Summary: the goal of this study is to increase the efficiency of exposure in virtual reality (vr). based on the emdr research the investigators would like to show that the implementation of eye movements during the vr exposure results in a faster physiological relaxation response among probands with spider phobia, which has a positive effect on the subjective and behavioral efficacy of the vr exposure.

the vr paradigm consists of one room with a spider in it. the proband is supposed to look at it for a few minutes. this exposure is repeated several times. in the experimental group a ball appears during the exposure, that moves horizontally across the room. the probands are supposed to follow this movement with their eyes. eda, ekg and respiration are being recorded. furthermore the subjective and behavioral spider phobia is measured before, during and after the exposure to determine occurring changes.

Eligibility criteria:
inclusion criteria: * the structured clinical interview for dsm-iv (scid, first et al., 2002; applied german translation: strukturiertes klinisches interview für dsm-iv, achse i, skid i, wittchen et al., 1997), in order to get a reliable diagnosis of spider phobia exclusion criteria: * pregnancy * current psychopharmacological medication * current involvement in psychiatric- or psychotherapeutic treatment * cardiovascular or neurological diseases * color blindness * hearing disorders
fructosamine as a predictor of surgical outcomes in total joint arthroplasty a prospective multi-center study

Conditions: Infection

Summary: a prospective multicenter study including all patients undergoing elective total hip (tha) or knee (tka) arthroplasty (primary and revision). patients will be screened for glycemic control using hba1c levels, fructosamine levels, and blood glucose levels. blood samples will be obtained at the preadmission testing (pat) within 30 days of surgery. on postoperative day 1 (pod-1), morning glucose levels will be obtained for all patients as well. patients will be followed up for 90 days postop. study aims 1. to examine the association between serum fructosamine levels and the risk for adverse outcomes (mainly pji) following tja among patients with and without diabetes. 2. to compare the utility of fructosamine levels to hba1c in predicting adverse outcomes. 3. to determine the "best" threshold of fructosamine to determine adverse outcomes.


Eligibility criteria:
inclusion criteria: all patients undergoing elective total hip (tha) or knee (tka) arthroplasty (primary and revision) exclusion criteria: none
comparison of different neural blockade techniques in postoperative analgesia after total hip arthroplasty

Conditions: Pain, Postoperative

Summary: to compare the different analgesic protocols for patients receiving total hip arthroplasty(tha). patients will divided into 3 groups, which are 1. fascia iliaca compartment block with iv-pca(patient controlled analgesia), 2. femoral nerve and lateral femoral cutaneous nerve block with iv-pca, 3. iv-pca only.

90 patients will be enrolled and randomized to the 3 different groups. 1. inclusion criteria: patient undergoing tha: 20-75 years old, asa i-iii, general anesthesia with intubation, fentanyl iv pca. 2. exclusion criteria alcohol/substance abuse rheumatoid arthritis severe coagulation disorder(plt\ 1.5) peripheral neuropathy allergy to opioids or local anesthetics bmi\>35 3. the outcome followers are blinded to the intervention provided. 4. outcome parameters: 1. opioid consumption of iv pca in first 24 hrs. 2. nsaid consumption 3. nrs of pain, the timings of follow-up should be: pre-block, 30 mins post-block, 60 mins post-block, 2 hours post-block, 24hours post-block 4. sensory block in fn, obturator nerve and lfcn 5. first request of supplemental iv analgesia

Eligibility criteria:
inclusion criteria: * asa i-iii, general anesthesia with intubation. * fentanyl iv pca exclusion criteria: * alcohol/substance abuse * rheumatoid arthritis * severe coagulation disorder(plt\ 1.5) * peripheral neuropathy * allergy to opioids or local anesthetics * bmi\>35
sub-hertz analysis of viscoelasticity of limbs in patients with lymphedema

Conditions: Lymphedema

Summary: researchers are trying to validate the use of ultrasound sub-hertz analysis of viscoelastisty (save) method to monitor tissue-fluid dynamics and stage disease severity in patients diagnosed with lymphedema.


Eligibility criteria:
inclusion criteria: * adult (18+ years of age) * ability to provide written consent * has been diagnosed with lymphedema exclusion criteria: * under the age of 18 years old * inability to provide written consent * previous lymphovenous bypass or lymph node transfer surgery
lipids and neurological complications in liver transplantation

Conditions: Neurological Complications

Summary: to study the impact of pretreatment of living donor liver transplantation recipients with smof lipid on the incidence and severity of post-transplantation neurological complications in patients receiving tacrolimus based immunosuppression protocol

all patients included in the study will receive the same immuno-suppression protocol based on tacrolimus and mycophenolate mofetil after the induction immuno-suppression during the intra-operative period. patients will have a full history taking and full neurological examination 48 hours prior to the designated operative date as a basal record. the control group will not receive any lipid infusions at all the treatment group will receive the study emulsion (smof lipid 20% - fresenius kabi) starting 48 hours before the planned surgery day and will continue to receive it for 5 post-operative days by intravenous infusion. during the post-operative period. patients will be assessed daily by full neurological examination as will as patient complaints (symptoms) related to neurological status for diagnosis of any neurological conditions (complications) that might arise during the study period. data will be analysed compared to the basal value in each group and between both control and intervention groups using the appropriate statistical tests.

Eligibility criteria:
inclusion criteria: * adult living donor liver transplant recipients of either sex exclusion criteria: * meld score \> 30 * retransplantation * budd chiari syndrome * diabetes more than 10 years

Keywords: smof neurological complications neurotoxicity liver transplantation lipid emulsions
the effect of obstructive sleep apnea and its treatment on decision making

Conditions: Obstructive Sleep Apnea

Summary: obstructive sleep apnea (osa) is an extremely common disease with inadequately explored neurocognitive consequences. the investigators will study osa patients before and after treatment to understand how osa changes decision making abilities, and whether treatment can reverse such cognitive changes. these results could provide deeper insight into how osa affects decision making either temporarily or permanently, and provide another rationale or motivation for treatment of osa in adults.

the investigators hypothesize that osa will lead to (h1) more reward-seeking and lower payoffs in the iowa gambling task, replicating previous findings; (h2) greater discounting of future rewards in financial choices; and (h3) these effects would dissipate when osa is successfully treated. in order to test these hypotheses, the investigators will perform cognitive tests (iowa gambling; intertemporal choice; other measures) in 100 patients about to undergo sleep testing. it is expected that of these 100 patients, some will have no sleep apnea; some will have sleep apnea and will be successfully treated; and that some will have sleep apnea but will not be successfully treated by the time of repeat testing. the investigators will repeat testing using the same instruments 2 months later. thus the investigators will be able to compare whether osa patients differ from control at baseline (t1), and whether osa patients' performance will improve after treatment at t2, compared to the control at t2.

Eligibility criteria:
inclusion criteria: subjects aged 18-75 referred to the ucsd sleep clinic for either home or in-laboratory testing will be considered for inclusion in the study. inclusion will not depend on gender, race or ethnicity, as per the following: 1. 100 participants will be enrolled at the ucsd sleep clinic at chancellor park. 2. ages 18-75 3. gender: men and woman 4. ethnic background: all 5. health status: to the ucsd sleep clinic for either home or in-laboratory testing exclusion criteria: 1. ongoing cpap treatment for osa 2. inability to use a tablet device (e.g. no reading glasses, or unfamiliar with devices). 3. severe cardiopulmonary disorder that requires treatment with supplemental oxygen therapy. 4. inability to speak english fluently, as some of the questionnaires/tests are only validated in english.
fresh carts for mom's to improve food security and glucose management

Conditions: Gestational Diabetes Mellitus in Pregnancy; Type 2 Diabetes Mellitus

Summary: this study will look at the benefit of decreasing food insecurity and improving glucose control among women who either report gestational diabetes (gdm) at 20-28-weeks or have type 2 diabetes (t2dm) with a confirmed pregnancy. participants will receive a grocery prescription with delivery through instacart at the start of the study or after 12 weeks or frozen medically tailored meals delivered from door dash. researchers will compare the grocery prescription program, mtm (medically tailored meals), relative to standard of care to see if the impact on these food as medicine programs can improve glucose control over 12-weeks as compared to standard of care.

women who have a diagnosis of gestational diabetes (gdm) or type 2 diabetes (t2dm) and who report food insecurity using the hunger vital signs screener will be recruited to participate in a comparative study across two urban communities. one arm will receive a grocery prescription program from instacart health to be spent on eligible healthy food items based on my diabetes plate. the other arm will receive 10 frozen medically tailored meals delivered to their door each week. the meals are based on diabetes guidelines and are culturally appropriate. meals are created by a local nonprofit food pantry, dare to care, in louisville, kentucky and delivered via a partnership with door dash - project dash. women will be recruited initially from a registered nurse who works at the clinic sites. the study team will then enroll participants after eligibility screening and conduct further onboarding into the food as medicine package based on locations.

Eligibility criteria:
inclusion criteria: * diagnosis of gestational diabetes or type 2 diabetes * answer affirmative to one of two questions on the hunger vital signs * viable pregnancy * lives in a service area of instacart delivery * has a phone or computer which allows ordering food for delivery exclusion criteria: * does not speak english * does not have a phone, tablet, or computer to order groceries for instacart * plans to move within the next 3 months

Keywords: pregnancy food insecurity food as medicine
azathioprine or mycophenolate mofetil for bullous pemphigoid

Conditions: Bullous Pemphigoid

Summary: to investigate the safety and efficacy of oral methylprednisolone combined with azathioprine or mycophenolate mofetil for the treatment of bullous pemphigoid.

this multicenter randomized, non-blinded clinical trial compared two parallel groups of patients with bullous pemphigoid treated with oral methylprednisolone in combination with either azathioprine or mycophenolate mofetil. patients were randomly assigned, irrespective of severity of disease, to receive either 0.5 mg per kg body weight (bw) methylprednisolone (urbason®, aventis pharma, bad soden, germany) with 2 mg per kg bw azathioprine sodium (imurek®, glaxosmithkline, munich, germany) once daily or 0.5 mg per kg bw methylprednisolone once daily and 1,000 mg mycophenolate mofetil (cellcept® provided by hoffmann-la roche ag, grenzach-wyhlen, germany), given twice daily (2 g/d). the initial dose was maintained until blister formation ceased, crusts as well as erosions disappeared, and re-epithelialization of previous lesions started. the corticosteroid dose was then sequentially reduced by 10 mg every two weeks until a dose of 20 mg per day was reached followed by a reduction in 5 mg-steps every two weeks until 10 mg per day. afterwards, corticosteroid reduction was performed in 2.5 mg-steps every two weeks until zero. after discontinuation of corticosteroids azathioprine or mycophenolate mofetil doses were maintained at the initial dosage as monotherapy for an additional 4 weeks. subsequently, azathioprine was reduced by 0.5 mg per kg bw every four weeks to a dose of 100 mg per day. thereafter, azathioprine was tapered in 25 mg-steps every four weeks until discontinuation of treatment. mycophenolate mofetil was reduced in 500 mg/d-steps every four weeks to 1,000 mg per day. from then on the mycophenolate mofetil dosage was decreased in 250 mg-steps every four weeks until discontinuation of treatment.

Eligibility criteria:
inclusion criteria: * clinical lesions suggestive of bullous pemphigoid * subepidermal blistering upon histological analysis of skin biopsies * linear deposition of igg and c3 along the dermo-epidermal junction * deposition of autoantibodies at the blister roof upon split-skin analysis exclusion criteria: * treatment with oral or topical corticosteroids, and other immunosuppressive drugs during the previous four weeks

Keywords: bullous autoimmune disease bullous pemphigoid immunosuppressants corticosteroids mycophenolate mofetil
early childhood obesity prevention program

Conditions: Body Weight Changes

Summary: this study is proposed on behalf of the hartford childhood wellness alliance, a 107 member, 35 group organization whose goal is to improve the health of children in hartford, ct. in a randomized control trial, the primary aim of this study is to test the initial efficacy of a program of enhanced home visitation with neighborhood and community support to change maternal behaviors related to infant nutrition (sweetened beverage/juice consumption, breastfeeding and introduction of solids), parenting skills (establishing routines around sleep, reading cues for hunger, satiety, television time) and family wellness (improving the home food environment, enhancing physical activity). the investigators hypothesize that at 12 months of age, infants in the intervention arm will drink less sugar sweetened beverages/juices, will have ingested solids at an older age, will have been breastfed longer and more exclusively than infants in the control arm and will have less tv viewing, more established sleep routines and greater soothability (primary outcomes).

see manuscript: 125. cloutier mm, wiley j, wang z, grant a, gorin aa. the early childhood obesity prevention program (echo): an ecologically-based intervention delivered by home visitors for newborns and their mothers. bmc public health, 15:584 pmid 26073106, 2015.

Eligibility criteria:
inclusion criteria: * enrolled in the nurturing families network program * singleton birth \>34 weeks gestation * any race or ethnicity * echo neighborhood * mothers and their newborns exclusion criteria: * mothers or newborns with special health care needs * infant with major malformation * small for gestational age/low birth weight

Keywords: childhood obesity breastfeeding introduction of solids introduction of juice
proton therapy in reducing toxicity in anal cancer

Conditions: Anus Neoplasms

Summary: the purpose of this research study is to determine whether the amount of radiation given to the normal areas around the anal cancer can be reduced by using proton therapy while reducing the side effects that are seen with standard therapy.


Eligibility criteria:
inclusion criteria: * karnofsky performance status \>70% * histologically documented squamous or basaloid carcinoma of the anal canal * stage t2-4 disease with any n category exclusion criteria: • patients with a life expectancy of \< 3 months.

Keywords: anal cancer
effect of bioptron light on carpal tunnel syndrome(blcts)

Conditions: Carpal Tunnel Syndrome Pregnancy

Summary: the purpose of this study is to investigate the effect of bioptron light therapy on pregnancy related carpal tunnel syndrome

carpal tunnel syndrome (cts) is a symptomatic compression neuropathy of the median nerve at the level of the wrist, characterized by hand pain, numbness, and tingling in the distribution of the median nerve (thumb, index, middle finger, and the radial side of the ring finger) and a reduction in grip strength and hand function. the severity of symptoms can be clinically categorized into mild, moderate, and severe bioptron phototherapy acts as a "sterile" trigger on human in vitro isolated peripheral blood mononuclear cells (pbmcs), affecting their cytokine production and driving the immune response towards an anti-inflammatory/reparative profile and representing a non-pharmaceutical and non-invasive option for several clinical conditionsa randomized control study, the women will be randomly assigned into two groups, (31 women for each group) equal in number. group (a) will include 31 women will receive bioptron light combined with advice and patient education (10 minutes per session, 3 sessions per week, for 4 weeks). group (b) will be receiving advice only for same duration as group (a)

Eligibility criteria:
inclusion criteria: * pregnant females clinically daignosed with carpal tunnel syndrome at least 1 month * age will range from (25-35) years. * body mass index (bmi) will be (bmi ≤ 35 kg/m2) exclusion criteria: * history of neurologic disease * hand surgery * hand trauma, * diabetes mellitus * cervical spondylosis * osteoarthritis of cervical spine and wrist joint * chronic renal failure * heart failure * connective tissue disorders

Keywords: bioptron light therapy phototherapy carpal tunnel syndrome
frequent standardized oral care to improve health outcomes in premature infants in the neonatal intensive care unit

Conditions: Microbial Colonization; Ventilator Associated Pneumonia

Summary: premature very low birth weight (vlbw) infants are susceptible to complications related to infrequent and non-standardized oral care. although the benefits of frequent standardized oral care are known to reduce oral dybiosis (increased level of potentially pathogenic bacteria) and its associated complications in critically ill adults leading to established evidence-based guidelines, no such information exists for vlbw infants. the proposed study will prospectively follow 40 vlbw infants for 4 weeks following birth. infants will be randomized into 1 of 2 groups. standardized oral care will be performed every 3-4 hours (group 1) and every 12 hours (group 2). aim 1 will evaluate the feasibility of frequent standardized oral care, aim 2 will compare the oral microbiome between groups, and aim 3 will compare respiratory outcomes including the incidence of ventilator associated pneumonia, bronchopulmonary dysplasia and need for respiratory support between infants receiving standardized oral care every 3-4 hours and every 12 hours. issues related to recruitment, retention, randomization, acceptance by nursing staff, and treatment fidelity will be examined. saliva samples will be obtained weekly and analyzed using 16s sequencing, respiratory cultures will be obtained weekly on ventilated infants, and respiratory outcomes will be collected from the medical records.


Eligibility criteria:
inclusion criteria: * gestational age \< 32 weeks * birth weight \< 1500 grams * mother is english speaking * mother is \> 18 years of age. exclusion criteria: * congenital anomalies of the face, lungs, or gastrointestinal system * not expected to survive