Kornimate/medical-research-clean huggingface dataset:
letrozole or combined metformin clomiphene citrate (cc) for women with cc resistant polycystic ovary syndrome

Conditions: Polycystic Ovary Syndrome

Summary: the purpose of this study is to compare and determine the efficacy of letrozole administration to that of combined metformin and clomiphene in infertile women with polycystic ovary syndrome (pcos) not responding to treatment with clomiphene alone.

withdrawal bleeding was achieved using 10 mg of dydrogesterone tablets for 10 days before stimulation. in the letrozole group, 2.5 mg of letrozole oral tablets (femara; novartis pharma services, switzerland) daily from day 3 of the menses for 5 days, whereas all patients in the combined metformin-cc group) received metformin hcl \[cidophage®; chemical industries development(cid), cairo, egypt\], 500 mg three times daily for 6-8 weeks. then after the end of this period, they received 150 mg cc (clomid®; global napi pharmaceuticals, cairo, egypt) for 5 days starting from day 3 of menstruation. patients continued treatment for three successive cycles using the same protocol. metformin was stopped only when pregnancy was documented.

Eligibility criteria:
inclusion criteria: * cc resistant pcos exclusion criteria: * congenital adrenal hyperplasia * cushing syndrome * androgen secreting tumors

Keywords: polycystic ovary syndrome clomiphene resistance letrozole
soy as an innovative dietary component in abdominal obesity management amongst peri- and early menopausal women

Conditions: Central Obesity

Summary: this is a pilot study examining the effect of dietary supplements that contain soy products. the purpose of this study to find out if soy supplementation can help to reduce the storage of a certain kind of fat on the body, visceral fat. visceral fat is fat found deep in the abdomen; it has the potential to increase the risk of certain health problems.

obesity is a leading risk factor for many chronic diseases in the usa. abdominal fat, specifically visceral fat is metabolically active and can be detrimental to health. abdominal obesity is especially high in postmenopausal women (prevalence rates 50- 70%) in whom estrogen deficiency may lead to accumulation of excess visceral fat. although estrogen replacement therapy is effective in preventing visceral fat accumulation, its adverse effects warrant a search for a safer phytochemical that exerts estrogenic properties. soy, containing isoflavones (estrogen-like compounds), is a promising dietary component in reducing abdominal obesity in menopausal women. the favorable effects of isoflavones were already demonstrated in animal studies.the effects of soy compounds as a dietary component in preventing and reducing abdominal obesity and its associated metabolic abnormalities will be examined among menopausal women. we will use quantitative magnetic resonance spectroscopy/imaging (qmrs/i) to determine dose and effects of soy supplementation for preventing and treating abdominal adiposity. the results from this study will shed light on the application of soy as a novel dietary approach in preventing and managing abdominal obesity among peri- and early menopausal women.

Eligibility criteria:
inclusion criteria: 1. between the ages of 45 and 60 2. experiencing irregular menses along with one or more other symptoms of menopause including: vaginal dryness, difficulty sleeping, hot flashes, mood changes, increased abdominal/belly fat, or with cessation of menstrual cycle for no more than three years 3. having a bmi greater than 25 4. waist circumference greater than 88 cm 5. having the ability to understand study procedures and to comply with them for the entire length of the study. exclusion criteria: 1. have ever been diagnosed with cancer 2. have tumors in the reproductive system 3. allergies to soy or milk protein 4. have known metabolic disorders that may affect body weight and body composition (e.g., hypercortisolism and hypothyroidism, non-alcoholic fatty liver disease) 5. are receiving hormone replacement therapy or estrogen-like remedy 6. are taking medications (e.g., thyroid, cortisol/cortisone, ephedra, thermogenics, etc) within 30 days prior to the start of the study. 7. are emotional or uncontrolled eaters as measured by a brief screening tool three-factor eating questionnaire (tfeq), i.e., 3 "yes" to the three emotional eating questions or 2 "yes" to the 2 uncontrolled eating questions.

Keywords: obesity prevention soy supplementation
vaginal douching and painting in women who underwent total abdominal hysterectomy

Conditions: Febrile Morbidity

Summary: comparison of the effectiveness of povidone-iodine douching and painting for reducing febrile morbidity after total abdominal hysterectomy

total abdominal hysterectomy (tah) is the most common gynecologic operation worldwide. the two most common complications after tah are febrile and infectious morbidities, incidence varying between 5 and 50 percent. after performing tah, vaginal canal must be breached and closed to be blind-pouch stump. routing vaginal douching at the night before and on the morning of the surgical date, and intra-operative painting are routinely practiced. however, no good quality of evidence base supports the effectiveness of vaginal douching and painting in preventing febrile and infectious morbidities after tah.

Eligibility criteria:
inclusion criteria: * women who undergoing total abdominal hysterectomy * woman who agrees to participate in this study exclusion criteria: * women with history of sea-food or iodine allergy * women who undergo emergency tah * women who have intestinal resection in this operation * women who have active pelvic inflammatory disease before operation * women who have fever before operation * women who received antibiotic within 1 weeks before operation * women who be immunocompromised host
effect of a warming mattress on perioperative hypothermia following cesarean delivery

Conditions: Postoperative Hypothermia

Summary: the primary aim of the current study will be to determine if the use of an underbody heating mattress during cesarean sections will decrease the incidence of postoperative hypothermia, defined as core temperature less than 36c, and if hypothermia occurs, time to normothermia. as part of the primary outcome the difference in the incidence of shivering, its severity, and need for treatment will be investigated. as a secondary goal other maternal perioperative outcomes will be studied i.e. estimated blood loss, change in hemoglobin level on the morning after surgery ie postop day 1, need for blood transfusion, rate of wound infections, length of hospital stay, maternal satisfaction, time to first breastfeeding, time to first 'skin to skin' contact. the relationship between maternal hypothermia and newborn outcomes of temperature and apgar scores will also be evaluated. active preoperative and intraoperative warming may prevents inadvertent perioperative hypothermia and may be beneficial for pregnant patients undergoing cesarean delivery. the underbody warming mattress may be a step towards finding a suitable form of warming that is comfortable for awake patients, does not interfere with skin to skin contact and maternal-fetal bonding.


Eligibility criteria:
inclusion criteria: * will be age \>18 years, * singleton pregnancy \>37 weeks, * neuraxial anesthesia, * healthy afebrile patients. exclusion criteria: * • will be age \>18 years, * singleton pregnancy \>37 weeks, * neuraxial anesthesia, * healthy afebrile patients.

Keywords: perioperative warming
efficacy of different anesthesia methods in transbronchial biopsy

Conditions: Anesthesia; Respiratory Diseases; Biopsy

Summary: this study investigates the efficacy of different anesthesia methods (general anesthesia with laryngeal mask airway and local nebulized anesthesia) for transbronchial biopsy using an electronic bronchoscope. the study retrospectively analyzed cases of transbronchial biopsy performed at the respiratory endoscopy center of sichuan provincial people's hospital from june 5, 2020, to june 5, 2024. data collected included age, gender, primary diagnosis, anesthesia method, biopsy method, operation time (excluding general anesthesia and laryngeal mask airway placement time), lesion location and size, pathological results, and follow-up status.

general anesthesia and local anesthesia are the primary anesthesia methods for interventional respiratory endoscopy. while general anesthesia offers greater comfort, it carries anesthesia-related risks. local anesthesia, on the other hand, provides a relatively low surgical risk and cost-effectiveness. however, there is limited research on whether its diagnostic value is inferior to that of general anesthesia.this study investigates the efficacy of the two anesthesia methods (general anesthesia with laryngeal mask airway and local nebulized anesthesia) for transbronchial biopsy. the study retrospectively analyzed cases of transbronchial biopsy performed at the respiratory endoscopy center of sichuan provincial people's hospital from june 5, 2020, to june 5, 2024. data collected included age, gender, primary diagnosis, anesthesia method, biopsy method(forcep/cryobiopsy), operation time (excluding general anesthesia and laryngeal mask airway placement time), lesion location and size, pathological results, and follow-up status(pneumothorax、hemorrhage).

Eligibility criteria:
inclusion criteria: * completed transbronchial biopsy；the platelets count and pt, aptt tests were normal, normal ecg, anesthesiologist evaluation was needed in general anesthesia group. exclusion criteria: * patients with contraindication of bronchoscopy (such as respiratory failure and acute cardio-cerebrovascular events), and women who were pregnant.

Keywords: anesthesia method bronchoscopic biopsy efficiency research
the effect of physiotherapy on cervicogenic somatic tinnitus

Conditions: Tinnitus

Summary: the purpose of this study is to determine whether physiotherapy is effective in the treatment of a group of tinnitus patients with neck complaints.


Eligibility criteria:
inclusion criteria: * severe chronic non-fluctuating subjective cervicogenic somatic tinnitus, which has been stable for at least three months, combined with neck complaints exclusion criteria: * objective tinnitus * subjective tinnitus with etiologies, such as hearing loss or meniere's disease, severe depression (\> 19 on the beck depression questionnaire) * progressive middle ear pathology * intracranial pathology * traumatic cervical spine injury * tumors * cervical spine surgery * any cervical spine condition in which physical therapy treatment is contra- indicated * received physical therapy treatment directed to the cervical spine in the past 2 months
adolescent digital mental health-kenya effectiveness

Conditions: Mental Disorder in Adolescence

Summary: this study seeks to respond to the growing burden of adolescent mental health disorders and urgent preventive service needs in kenya by studying the effectiveness of a digital health intervention- mobile health (mhealth) toolkit for screening \& empowering lives of youth (msely)-that has demonstrated feasibility from our prior pilot study. the investigators will build on this work and examine two versions of msely. the msely-a is designed for adolescents to self-evaluate and manage psychological wellbeing/mental health needs, as well as to gain resources and access and connect with adolescent peers. the msely-p is designed for parents to self-evaluate their adolescent's development and mental health, gain awareness about their adolescent's mental health status, and learn strategies and resources to support adolescents' mental health. both versions provide screening, tailored mental health literacy materials, and decision support for adolescents and/or their parents. this study will examine the effectiveness of these digital interventions using a randomized control trial with diverse community-based organizations in kenya. in addition, the investigators will study underlying mechanisms that contribute to intervention effectiveness, as well as to use the data for precision medicine analysis (using machine learning approach). findings will be used to improve digital-toolkit decision support functions and accuracy of mental health precision care.


Eligibility criteria:
adult parent and adolescent child will be enrolled in this study as a family. inclusion criteria: * parent is over 18 years of age * parent has as an adolescent child between 11-14 years of age who attend one of our partnering schools/community-based organizations (cbos). * parent is willing and able to provide consent for themselves and provide assent for their child * adolescent is between 11-14 years in age who attend one of our partnering schools/cbos. * one of adolescents adult parent (\>18 years old) is "interested in" participating in this study * adolescent is willing and able to provide child assent exclusion criteria: * parents (including biological and non-biological) who have no contact with adolescents for over 1 month
the eggs and activity in health aging pilot (even-p) trial in older persons

Conditions: Aging

Summary: two of the most effective lifestyle-based approaches to reduce the risk of adverse health events and enhance quality of life with aging are exercise and a healthy diet. currently, the canadian recommended dietary allowance (rda) for protein is 0.8 g/kg/day, however, several expert groups have advocated for a higher rda of protein (\~1.2 g/kg/day), along with more evenly distributed daily consumption, in older persons. eggs are considered a nutrient-rich protein source but have recently been scrutinized. this study will compare a high-protein, egg-containing diet and a high-protein, non-egg diet in healthy older persons.

this study will examine the impacts of an egg-containing diet and a non-egg diet in healthy older persons. briefly, participants (healthy persons, age 60-75 years old) will consume their normal diet or their normal diet plus 4 eggs completing a structured exercise program (designed to meet canada's physical activity guidelines) for a total of 12 weeks. participants will be randomly assigned to the egg or control (non-egg) group. before and after the 12-week intervention, participants' undergo assessments of diet-quality, muscle health, fitness, bone health, and vascular health.

Eligibility criteria:
exclusion criteria: 1. use assistive walking devices (e.g. cane or walker) 2. consume any analgesic (pain-relieving) or anti-inflammatory drug(s), prescription or non-prescription, chronically 3. a history of neuromuscular problems or muscle-wasting diseases 4. any acute chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin or non-insulin dependent diabetes or other metabolic disorders- all ascertained through medical screening questionnaires 5. chronic consumption of statins (particularly simvastatin/zocor and atorvastatin/lipitor) used to lower cholesterol 6. be on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription-strength acne medications) 7. have allergies or are not willing to consume eggs 8. consume a vegetarian diet 9. had significant weight gain or loss in the past 6 months 10. have injuries preventing the safe completion of the exercise

Keywords: muscle diet sarcopenia vascular health
a comparison of physical activity levels with and without feedback via fitbit® flex™ in hemodialysis patients

Conditions: End Stage Renal Disease

Summary: this is a pilot study intended to gather data in order to inform future studies about the role of feedback as an incentive for increasing levels of physical activity which could improve health in hemodialysis patients.

in prior studies that have analyzed physical activity in dialysis patients, three-dimensional accelerometers, physical performance tasks or self-reporting physical activity questionnaires have been used to measure levels of activity. this proposed study differs in that it will determine the effectiveness of providing "feedback" to dialysis patients using a fitness tracking bracelet. for the purpose of this study, the word 'feedback' is used to refer to the information provided to the subject that demonstrates the number of steps taken since the previous dialysis session as displayed by the fitbit® application. this 'feedback' will allow subjects to be more aware of their overall physical activity on a quantitative level. the study will seek to explore an association between feedback and physical activity. improved physical activity could improve indicators of subjects' health status such as blood pressure, inflammatory markers, and pre-albumin levels, which will also be monitored and recorded. while informing subjects quantitatively about their levels of physical activity could be a promising method to encourage them to be more active, it is unclear at this point if that strategy actually works. this is an important practical question though, because actually informing subjects on a regular basis about their activity level may pose substantial operative challenges and result in additional costs. the importance of encouraging subjects to be more physically active should not be underestimated. studying the physical activity of dialysis patients is important because it allows researchers to consider the long-term effects that may influence the subject's well-being. johansen et al. showed that there was a direct relationship between the inactivity of dialysis patients and susceptibility to hypertension, diabetes, cardiovascular disease and even mortality. additionally, the study demonstrated the importance of implementing programs to promote physical activity \[1\]. if feedback does indeed increase physical activity, then it will be substantially beneficial for this program to be implemented.

Eligibility criteria:
inclusion criteria: * receiving hemodialysis three times a week * on hemodialysis for more than 3 months * between the ages of 18 and 75 years * able to walk without assistance or assistive devices * able to read and understand the english language exclusion criteria: * patient already uses an activity tracker * unstable health: acute infections, congestive heart failure nyha class 4 and/or unstable angina * hospitalization within the past 3 months for non-access related reasons * known allergies to nickel * unable to physically grip the handheld dynamometer in order to complete the hand grip strength test * cognitive impairment

Keywords: exercise
comparison evaluation of blood glucose meter systems in a clinical setting

Conditions: Diabetes

Summary: the purpose of this study was to test the performance of an investigational bayer blood glucose (bg) meter and five additional blood glucose monitoring systems (bgmss). the goal was to obtain glucose samples from subjects with diabetes across the meter operating ranges. a capillary sample was collected from each subject at 3 different times during the visit to obtain natural capillary blood samples with a range of glucose concentrations. some blood samples were glycolyzed to lower the glucose concentration levels and glucose solution was added to other samples to raise glucose concentration levels. all meter bg results were compared with plasma results obtained with a reference laboratory glucose method (ysi glucose analyzer). all lancings and testing were performed by study staff.


Eligibility criteria:
inclusion criteria: * diagnosis of type 1 or type 2 diabetes mellitus * 18 years of age or older * willing to follow all study procedures exclusion criteria: * received an investigational drug or device within the last 30 days * current use or recent exposure to any prescription medication within 24 hours prior to screening that in the opinion of the investigator could have an influence on the subject's ability to participate in the study or on the performance on the test device * positive pregnancy test obtained at screening (test performed for females only, except if surgically sterile or three years past menopause) * hematocrit \ 55% * inadequate veins (in the opinion of the investigator or designated study staff) for venous blood withdrawal or intravenous catheter insertion * symptomatic coronary artery disease with a history of angina, or history of a myocardial infarction or coronary intervention (e.g. percutaneous transluminal coronary angioplasty \[ptca\], stent placement) or coronary artery bypass graft (cabg) within the past 6 months * cerebrovascular accident within the past 6 months * diagnosis of the following diabetic autonomic neuropathies: symptomatic orthostatic hypotension, heart rate anomalies, gastroparesis * being treated for malignancy, except basal cell or squamous cell skin cancers * major surgical operation within 30 days prior to screening * active alcohol abuse or substance abuse (as judged by the principal investigator) * severe mental illness, mental incapacity, unwillingness or language barriers precluding adequate understanding or cooperation (as judged by principal investigator) * other medical conditions that would pose safety concerns, interfere with study conduct or seriously compromise study integrity, as judged by principal investigator (reason for exclusion will be clearly documented by investigator or designee) * working for a competitive medical device company, or having an immediate family member or someone who is not a family member but is living within the household of someone who works for such a company