Kornimate/medical-research-clean huggingface dataset:
organophosphate pesticides and human reproductive health

Conditions: Fecundability; Spermatazoa Disorders; Menstruation Disorders; Endocrine Dysfunction

Summary: this prospective cohort study assesses the effects of exposure to organophosphate (op) pesticides on adverse reproductive outcomes in both male and female agricultural workers in china. we will enroll women and their spouses, who are attempting to become pregnant, and observe reproductive endpoints including (1) semen parameters (concentration, total count, motility, progression and morphology), (2) menstrual disorders (oligomenorrhea, amenorrhea, polymenorrhea, intermenstrual bleeding, prolonged menstrual bleeding, dysmenorrhea, and irregular menstruation); (3) alterations in hormone patterns including reduced estrogen excretion (ree), anovulation, abnormal luteal phase (alp), and abnormal follicular phase (afp) in women and abnormalities of lh, fsh, tsh, shbg, inhibin-b and testosterone in men; (4) fecundability; and (5) pregnancy outcomes including spontaneous abortion, preterm delivery, low birth weight, and intrauterine growth retardation.


Eligibility criteria:
inclusion criteria: * it must be the first marriage for both the woman and her husband and they must currently live in the study area; * the female's age must range from 20 to 34 years; * the couple has no plan to leave the study area in which they live for the next two years. exclusion criteria: * those who are currently pregnant; * those who have tried unsuccessfully to get pregnant for at least 1 year; * those who are current or former smokers; * those who plan to move in the coming year.
effectiveness of rifaximin on preventing postoperative recurrence in crohn's disease

Conditions: Crohn Disease

Summary: some studies have shown that rifaximin is effective in the management of crohn's disease. meanwhile, its adverse effect is tolerable. but no study has been conducted to assess its effect on preventing postoperative recurrence. thus, we conduct a randomised controlled study to assess the effect of rifaximin on preventing postoperative endoscopic recurrence in crohn's disease. the primary endpoint is the rate of endoscopic recurrence at 6 months.


Eligibility criteria:
inclusion criteria: 1. consecutive patients with crohn's disease undergoing intestinal resection of all macroscopic diseased bowel, with an endoscopically accessible ileocolic anastomosis; 2. enrolled patients without risk factor for the development of postoperative recurrence including penetrating disease behaviour, prior bowel resection, and active smoking. exclusion criteria: 1. severe comorbidities; 2. with a stoma; 3. with malignancy; 4. pregnancy; 5. with contraindication of using rifaximin.
study of metabolic, transcriptomic and proteomic characteristics in relapsed glioblastoma

Conditions: Relapsed Cancer; Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype

Summary: glioblastomas are the most frequent and aggressive malignant tumors of the cns in adults, with almost systematic relapse despite treatment with surgery followed by radio-chemotherapy (stupp protocol). the aim of this study is to better characterize transcriptomic, proteomic and metabolic changes in relapsed glioblastoma compared to the initial tumor, in order to identify new prognostic markers and potential new therapeutic targets.

glioblastomas are the most frequent and aggressive malignant central nervous system (cns) tumors in adults, with a median survival of only 14 months. current treatment is based on surgery followed by radiochemotherapy (stupp protocol), unchanged since 2005. clinical trials evaluating immune checkpoint inhibitors and targeted therapies have largely failed to demonstrate efficacy in these tumors. in order to better understand the oncogenesis of glioblastoma and identify potential new therapeutic targets, the study of the characteristics of relapsed tumors compared with the initial tumor seems relevant. the aim of this retrospective study is to investigate the transcriptomic, proteomic and metabolic characteristics of relapsed glioblastomas reoperated at the university hospital of bordeaux, france, between 2005 and 2023, for which tumor material is available. these analyses will be correlated with relapse-free and overall survival of the patients.

Eligibility criteria:
inclusion criteria: * age \> 18 years * surgery for both primary and recurrent glioblastoma between 2005 and 2023 at the chu de bordeaux exclusion criteria: * systemic therapy received for non-glioblastoma tumor

Keywords: recurrent glioblastoma prognostic metabolism proteomic transcriptomic microbiota
a lifestyle intervention for breast cancer survivors

Conditions: Breast Cancer

Summary: 1. the purpose of the study is to test the effectiveness of a new mail-based intervention for breast cancer survivors compared with standard lifestyle management and no-treatment. 2. this intervention addresses both lifestyle factors such as dietary and physical activities and psychological issues specific to breast cancer survivors to improve healthy behaviors.

participants will be assigned randomly to one of three groups: 1) newly developed mail-based intervention (targeting the teachable moment intervention; ttmi), 2) standard lifestyle intervention (slm), and 3) usual care. both ttmi and slm focus on health behaviors, however ttmi additionally addresses psychosocial issues specific to breast cancer survivors. all participants will complete questionnaires at the time they start the study, the end of the 4 months, and 3 months later for a follow-up. if participants are assigned to any of the intervention group, they will receive materials every other week for 4 months. if participants are assigned to the usual care group, they will receive the same materials as the standard lifestyle intervention et the end of the 7 months.

Eligibility criteria:
inclusion criteria: * first diagnosed with breast cancer in the past 1.5 years * stage 0\~2 breast cancer * no prior adjuvant treatment for another cancer * can read and write english * are not participating in other health behavior research right now exclusion criteria: * apparent serious mental disturbance * male breast cancer survivors

Keywords: breast cancer survivors lifestyle intervention health behaviors
dahanca 24: prognostic value of 18f-faza in head and neck squamous cell carcinoma (hnscc)

Conditions: Cancer of the Head and Neck

Summary: solid tumours contain varying degrees of hypoxia. studies show hypoxia to be associated with poor local control and survival, as hypoxia is a cause of resistance to radio- and chemotherapy and the development of a more aggressive tumour. previous attempts to measure hypoxia have been biased because the techniques have been invasive, not repeatable or difficult to apply on a routine basis. there is great interest in trying to measure hypoxia in tumours as this could lead to individualized hypoxia-modifying therapy and prediction of treatment response. additionally the investigators' knowledge of change in hypoxia over time is limited, but of great interest as individualised treatment, such as intensity-modulated radiation therapy (imrt) is emerging. 18f-faza, appears promising. it is a nitroimidazole, which gets trapped in hypoxic cells and can be detected by a positron emission therapy (pet) scan. compared to other nitroimidazoles, 18f-faza has superior biokinetics and thereby is believed to provide a faster and clearer image of hypoxia. the investigators' hypothesis is that 18f-faza can be used as a prognostic marker in hnscc.


Eligibility criteria:
inclusion criteria: * histological proven squamous cell carcinoma of the pharynx, larynx, oropharynx and hypopharynx * curative intent and no prior treatment * age \>= 18 years * stage t1-4 n0-n3 m0. * informed consent according to local guidelines and national law * the patient is able (psychological, sociological, geographical and physical) to carry through the treatment and follow-up * fertile women must use contraceptive devices (iud or oral contraceptives) exclusion criteria: * no serious concurrent medical disease * no metastasis * no prior disease that can affect the treatment, evaluation or outcome of current disease * no pregnant or breastfeeding woman
mk0524b bioequivalence study (0524b-070)

Conditions: Dyslipidemia

Summary: this study will evaluate: 1. the bioequivalence of simvastatin and simvastatin acid following dose of simvastatin (zocor™) given together with one tablet of mk0524a or as a component of the triple combination tablet mk0524b. 2. the bioequivalence of laropiprant and er niacin when administered as the triple combination tablet mk0524b or as the double combination tablet mk0524a given together with simvastatin.


Eligibility criteria:
inclusion criteria: * subject is in good health * subject is a nonsmoker * subject is willing to follow the study guidelines exclusion criteria: * subject has or has a history of any illness that might confound the results of the study or make participation in the study unsafe for the subject
zenith(r) low profile aaa endovascular graft clinical study

Conditions: Abdominal Aortic Aneurysms; Iliac Aneurysms; Aorto-iliac Aneurysms

Summary: the zenith® low profile aaa endovascular graft clinical study is a clinical trial approved by us fda to study the safety and effectiveness of the zenith® low profile aaa endovascular graft to treat abdominal aortic, aorto-iliac, and iliac aneurysms.


Eligibility criteria:
inclusion criteria: * abdominal aortic, aortoiliac, and iliac aneurysms of appropriate size * vessels suitable for endovascular access and aneurysm repair exclusion criteria: * less than 18 years of age * inability or refusal to give informed consent * disease considerations that would compromise patient safety or study outcomes * unsuitable arterial anatomy

Keywords: low profile abdominal aortic aneurysms endovascular
a clinical research of car t cells targeting cea positive cancer

Conditions: Lung Cancer; Colorectal Cancer; Gastric Cancer; Breast Cancer; Pancreatic Cancer

Summary: the main purpose of this research is to verify the safety of cea targeted chimeric antigen receptor t cells and to determine the proper dosage of car t cells infused.

chimeric antigen receptor (car)-modified t cells have demonstrated great successes in treating even late stage cluster of differentiation antigen 19 (cd19) positive b cell malignancies. but it has not yet been fully explored in solid tumors. the carcino-embryonic antigen(cea) is widely expressed in cancers like gastric cancer, lung cancer, pancreatic cancer, breast cancer and colorectal cancer. to confirm if car t cells still function in solid tumors, we have developed anti-cea car-modified t cells. preclinical studies have demonstrated effective killing of cea target cells. in this study, the cea cars, will be evaluated in cea positive gastric cancer, lung cancer, pancreatic cancer, breast cancer and colorectal cancer patients. the primary goal is to confirm its adverse effects including cytokine storm response and any other adverse effects. in addition, tumor targeting and disease status after treatment will also be evaluated.

Eligibility criteria:
inclusion criteria: 1. relapsed or refractory cea positive lung cancer, pancreatic cancer, gastric cancer, breast cancer and colorectal cancer. 2. kps\>60. 3. life expectancy\>3 months. 4. gender unlimited, age from 18 years to 80 years. 5. disease progresses but reserves reaction to recent treatments. 6. patients who have failed at least one line of a standard treatment. 7. no serious mental disorder. 8. patients must have adequate cardiac function(no cardiac disease, lvef≥40% ), adequate pulmonary function as indicated by room air oxygen saturation of \>94%, and adequate renal function(cr≤133umol/l). 9. no other serious diseases(autoimmune disease, immunodeficiency etc.). 10. no other tumors. 11. patients volunteer to participate in the research. exclusion criteria: 1. kps\<50. 2. patients are allergic to cytokines. 3. mods. 4. uncontrolled active infection. 5. acute or chronic gvhd. 6. treated with t cell inhibitor. 7. pregnancy and nursing females. 8. hiv affected. 9. other situations we think improper for the research.

Keywords: cea car t
hemodynamic optimization during major urological surgery

Conditions: Hemodynamic Instability

Summary: in this prospective observational study investigators aim to seek for any possible correlation between the venous to arterial carbon dioxide difference (pco2 gap) at the end of surgery and the percentage of time spent above a predefined threshold of stroke volume (sv) andn mean arterial pressure (map).

during major urological surgery (i.e. cistectomy) investigators will use a minimally invasive hemodynamic monitoring system (flotrac - vigileo, edwards ) to guide fluid therapy and vasopressors administration. more specifically stroke volume target will be defined as the maximum sv after a series of fluid boluses, with a 10% tolerance. map was considered adequate if above 65 mmhg. after the induction of anesthesia, then each hour during surgery until the end of surgical procedure investigators will assess the time of adherence to the hemodynamic protocol (in terms of both sv and map) and the correspondent pco2 gap. investigators expect to find an inverse proportionality between the two parameters explored.

Eligibility criteria:
inclusion criteria: * patients scheduled for major urological surgery * asa 1-2-3 exclusion criteria: * pregnancy * obesity with a bmi \> 35 * controindications to central venous catheter positioning * end-stage renal disease

Keywords: stroke volume goal directed therapy major urological surgery mean arterial pressure
virtual reality animation and ice massage on the hoku point

Conditions: Labor Pain

Summary: the goal of this study was to compare the effects of ice massage and virtual reality animation on labor pain, duration, and satisfaction with delivery. the main questions aims to answer are: h1 there are differences between ice massage group and/or virtual reality animation groups and the control group in women's' labor pain. h2 there are differences between ice massage group and/or virtual reality animation groups and the control group in women's' labor duration. h3 there are differences between ice massage group and/or virtual reality animation groups and the control group in women's' satisfaction. this randomized controlled trial (n = 94) includes three arms. two intervention groups (ice massage (img); virtual reality animation (vra)) and one control group, (cg). personal information form, and visual analog scale (vas) and birth satisfaction scale will used to collect data. frequency and percentage calculations, mann whitney u, kruskal wallis test, chi-square test, tukey's honestly significant difference test, and will used for data analysis.


Eligibility criteria:
inclusion criteria: * term primiparous and singleton pregnancies, * longitudinal and vertex position of the fetus, * body mass index (bmi) below 30, * cervical dilatation of 0-3 cm, * who agreed to participate in the study exclusion criteria: * applying pharmacological intervention during labor, * having a risky pregnancy, * want to withdraw from the study, * having ice allergy, * being visually impaired.

Keywords: birth pain, satisfaction ice massage virtual reality
a study of cm336 in patients with relapsed or refractory multiple myeloma

Conditions: Multiple Myeloma

Summary: this is a multi-center, open-label, phase 1/2 study in china to evaluate the safety, tolerability, efficacy, pharmacokinetics, pharmacodynamics and immunogenicity of cm336 in patients with relapsed or refractory multiple myeloma. this study consists of a dose escalation part (phase 1) and a dose extension part (phase 2 ). the safety and tolerability of cm336 will be evaluated in phase 1 study, as well as the maximum tolerated dose (mtd) and the recommended dose level for phase 2 study will be determined. the efficacy of cm336 will be evaluated in phase 2 study.


Eligibility criteria:
inclusion criteria: * eastern cooperative oncology group performance status (ecog) of 0-2. * patients with relapsed or refractory mm who have failed or are intolerant to all therapies with known clinical benefit; patients must have received at least 2 prior anti-myeloma therapies which must contain at least one proteasome inhibitor (pi), one immunomodulatory drug (imid), and one anti-cd38 monoclonal antibody (if available). exclusion criteria: * patients who had received bcma-targeted therapy. * patients who had received car-t therapy. * patients who had received anti-tumor therapy within 3 weeks or 5 half-lives (whichever is shorter) prior to the first dose of cm336.
white light vs narrow band imagingin the diagnosis of right sided colonic polyps in asymptomatic subjects undergoing screening colonoscopy

Conditions: Adenoma Colon

Summary: a randomized controlled crossover study to determine if narrow band imaging or white light endoscopy is superior in detecting right colonic polyps in average risk subjects undergoing screening colonoscopy

removal of colorectal adenomas prevents occurrence of cancers. it is recognized that colonoscopy can miss colorectal adenomas and early cancers. proximal colon polyp detection rate is lower compared to distal colon detection rates. this may be partially due to the higher prevalence of flat polyps and sessile serrated adenomas (ssas) which are harder to visualize. there is a need to further improve performance of colonoscopy. a second evaluation of the right colon within the same procedure may yield an additional detection rate of 5-10%, however retro-flexion has not proven to be superior to a second forward viewing examination. the use of chromo-endoscopy has been shown to improve detection of flat adenomas. narrow band imaging was introduced in year 2006. it is similar to chromo-endoscopy in that it provides more mucosal details. this enables endoscopists to accurately describe the pit pattern of adenomas. nbi has been used as a substitute to chromo-endoscopy. in pooled analysis, nbi is comparable to chromo-endoscopy in their sensitivity and specificity in the diagnosis of malignant colorectal adenomas. unfortunately, the use of nbi has not been shown to conclusively improve rate of colorectal adenoma detection. two of 3 randomized trials that compared wle to nbi showed a higher adenoma detection rate with the use of nbi. in a study by rex et al., the rate was however similar with either modality. in a pooled analysis, nbi was only marginally better than wle. the effective use of nbi depends on the quality of bowel preparation and the experience of endoscopist. in the presence of fecal matters, nbi tends to be dark and detection of small adenomas becomes difficult. the prototype bright nbi coupled with high definition resolution is likely to overcome this drawback of original nbi.

Eligibility criteria:
inclusion criteria: * asymptomatic subjects undergoing screening colonoscopy * age \> 50. * average risk subjects defined as those without a personal history of inflammatory bowel disease, colon adenoma or cancer or family history of fap or familial non-polyposis syndrome or first degree relatives having diagnosed to have colo-rectal carcinoma, no colonoscopy in past 5 years and, ability to provide a written consent to trial participation exclusion criteria: * unable to consent
the coach project: combined online assistance for caregiver health

Conditions: Traumas, Brain; Alzheimer Disease; Dementia; Head Injury; Concussion, Brain; TBI

Summary: this study evaluates the effect of a physical exercise + caregiver skills training on feelings of burden, mood, and biological markers of inflammation in persons who provide care for veterans with a tbi or dementia. half of the caregivers will participate in a balance and flexibility + caregiver skills training program, while the other half will participate in a moderate/high intensity aerobic and resistance + caregiver skills training program.


Eligibility criteria:
inclusion criteria: 1. individuals aged 18 - 85 2. distress associated with being the primary caregiver of a person with tbi or dementia 3. endorsement of at least two of the following items: felt overwhelmed, felt like needed to cry, angry or frustrated, distant or cut of from family or friends, moderate to high levels of stress, felt their health had declined 4. provide at least one hour of care (supervision or direct assistance) per week over the past three months 5. approval by primary care provider to participate in physical exercise 6. be proficient in spoken and written english exclusion criteria: 1. current or lifetime history of any psychiatric disorder with psychotic features 2. prominent suicidal or homicidal ideation 3. current alcohol or substance abuse 4. diagnosis of probable or possible dementia 5. a short portable mental status score of ≥ 8 6. participation in another caregiver intervention within the past year 7. lack of regular access to the internet 8. planned transfer of care recipient to another caregiver or nursing home within 12 months; 8) current severe cardiac disease (e.g., uncontrolled atrial fibrillation, defined as mean 24 hour heart rate \>85 beats/min, or 24 hour maximal ventricular rate \>150 beats/min; uncontrolled ventricular arrhythmias, defined as recurrent ventricular tachycardia \>3 beats in succession, or 24 hour pvc count \>20%; active pericarditis or myocarditis; class iii/iv heart failure and / or ejection fraction \< 20%; thrombophlebitis; pulmonary disease with a drop in o2 sat with exercise to 90% without oxygen; embolism within past 6 months) 9. inability to participate in an exercise stress test 10. morbid obesity (bmi \> 39) 11. inability to read, verbalize understanding and voluntarily sign the informed consent. caregivers meeting any of these exclusion criteria will be excluded from all aspects of this project.

Keywords: caregiver caregiving tbi dementia alzheimer's disease physical exercise physical activity psychosocial caregiver skills training