Kornimate/medical-research-clean huggingface dataset:
bariatric and metabolic surgery in patients over 65 years of age

Conditions: Obesity; Diabetes Mellitus, Type 2; Hypertension

Summary: a retrospective multicenter study that will analyze the results of surgical treatment of obesity in patients over 65 years of age.


Eligibility criteria:
inclusion criteria: * 65 years of age and more * undergone bariatric surgery exclusion criteria: * lost to follow up

Keywords: bariatric surgery elderly patients obesity-related diseases
impact of urethral mobility on the success of sling operations

Conditions: Urinary Incontinence

Summary: main objective is to evaluate the relation between the increased urethral mobility and unsuccessful treatment after tvt and tot operations. 140 patients will be included in the research who are planned to have tvt and tot operations with sui and mui diagnoses.female patients of 25 to 70 years of age who are positive for stress test will be included. all patients will be questioned for parity, body mass index, menopausal state, medical history, and examined for pop-q stage, urodynamy, stress test, udi 6, iiq7 and with transperineal sonography preoperatively. "passive mobility angle" and "active mobility angle" will be measured. the relationship between passive mobility angle or active mobility angle and success of sling operations will be determined in this study.

transperineal sonography will be performed in a 300 cc filled bladder state, on a horizon which connects the lower margin of the pubic bone and the lower side of the urethral part of the bladder. first measurement will be done on litotomy position in resting state, second on 45 degrees reverse trandelenburg position in resting state and third one on 45 degrees reverse trandelenburg position in maximal valsalva straining state. the alteration between the angles measured at resting litotomy position and the resting reverse trandelenburg position is named as "passive mobility angle" (trigger gap) and the angle measured between the trigger gap and maximal valsalva state is named as "active mobility angle". furthermore, post voiding residues have also been measured by transperineal ultrasonography.

Eligibility criteria:
inclusion criteria: * 140 patients will be included in the research who are planned to have tvt and tot operations with sui and mui diagnoses between march 1, 2013 and january 1, 2015 in kanuni sultan suleyman medical research and educational hospital. exclusion criteria: * patients with level 3 or higher level of uterine descensus, previous urinary incontinence surgery, overactive bladder and who are unwilling for randomization will not been included.
fever observational study

Conditions: Fever

Summary: to inform the feasibility of conducting a study to test different temperature thresholds at which clinicians deliver interventions to reduce fever (i.e. antipyretic interventions) in critically ill children with fever due to infection.

fever (high temperature) is a normal bodily response to an infection, which has shown to have a beneficial effect in humans with chickenpox, malaria and rhinovirus infections. in children it has been recommended by the national institute for health and care excellence not to cool down the child using drugs or physical methods such as a cooling mat, with the sole aim to reducing the child's temperature. however, this recommendation is not aimed at the management of critically ill children, to which there is uncertainty around use of cooling interventions when considering the advantages of a fever in defending the body against viruses and bacteria during critical illness, and weighing that up with the possible negative physiological consequences of a high fever e.g. increased metabolic rate. observational studies show that the treatment of fever in critically ill children is inconsistent. there is a lack of robust data to guide antipyretic intervention, with clinicians usually starting fever management at around 37.5°c. evidence is emerging that fever may be beneficial in critically ill adults. due to the physiological differences between adults and children there is an important need to evaluate whether a different approach to fever management in critically ill children may also be beneficial. prior to conducting a large, expensive, randomised clinical trial (rct) to evaluate whether a higher temperature threshold in starting treatments to cool down the child would be beneficial, we are conducting three studies to know if it is possible for us to test key outcome measures as a result of testing different temperatures thresholds for antipyretic management. the fever observational study is one of these studies, with the aim of identifying: the potential population that would be eligible for the proposed definitive trial, current temperature threshold(s) for fever management, and to describe the characteristics of outcome measures with the intention of deciding on a main measure to see which treatment method was more successful.

Eligibility criteria:
inclusion criteria: unplanned picu admission referral requiring picu admission to a participating unit
efficacy and safety of quetiapine fumarate in the treatment of schizophrenic patients

Conditions: Schizophrenia

Summary: the primary objective of this study is to evaluate the efficacy of quetiapine fumarate extended-release (xr) used as mono-therapy, administered once daily, in the treatment of schizophrenic patient with acute episode.


Eligibility criteria:
inclusion criteria: * schizophrenia diagnosis * provision of written informed consent before initiation of any study exclusion criteria: * aids and hepatitis b * history of seizure disorder * hospitalisation for schizophrenic more than 1 month immediately before enter into study

Keywords: quetiapine fumarate (seroquel) extended-release (xr) qualified panss assessment
haic compared with tace in huge hepatocellular carcinoma

Conditions: Hepatocellular Carcinoma; Hepatic Chemotherapy; Liver Cancer

Summary: this study intends to compare the efficacy of transcatheter arterial chemical embolization (tace) with hepatic arterial infusion chemotherapy (haic) for patients with intermediate-advanced huge hepatocellular carcinoma.

transcatheter arterial chemoembolization (tace) and hepatic arterial infusion chemotherapy (haic) are effective and safe for hepatocellular carcinoma (hcc). for huge hcc (≥10 cm), the prognosis of this high tumor-burden subtype usually indicates poor outcome and big challenge. tace is difficult to completely embolize all tumor arteries, so patients have limited benefit from pure hepatic artery embolization. at the same time, excessive embolization will lead to massive tumor necrosis in a short time, and inflammatory necrosis factor will enter the blood, resulting in systemic inflammatory response. haic have showed good efficacy especially for advanced huge hcc (≥10 cm) complicated with portal vein tumor thrombus and arteriovenous fistula, and haic therapy can be performed with better and higher tumor control.

Eligibility criteria:
inclusion criteria: 1. clinical diagnosis of primary hcc. 2. age between 18 and 75 years; 3. the maximum tumor size ≥10 cm; 4. intermediate-advanced huge hcc, advanced hcc with pvtt type i-iii 5. limited metastases (≤5). 6. child-pugh class a or b; 7. eastern cooperative group performance status (ecog) score of 0-1; 8. hemoglobin ≥ 8.5 g/dl total bilirubin ≤ 30mmol/l serum albumin ≥ 32 g/l asl and ast ≤ 5 x upper limit of normal serum creatinine ≤ 1.5 x upper limit of normal inr ≤ 1.5 or pt/aptt within normal limits absolute neutrophil count (anc) \>1,500/mm3 9. prothrombin time ≤18s or international normalized ratio \< 1.7. exclusion criteria: 1. recurrent hcc; 2. extrahepatic metastasis \>5; 3. obstructive pvtt involving mesenteric vena cava (pvtt iv). 4. serious medical comorbidities. 5. evidence of hepatic decompensation including ascites, gastrointestinal bleeding or hepatic encephalopathy 6. eastern cooperative group performance status (ecog) score of ≥2; 7. known or suspected allergy to the investigational agents or any agent given in association with this trial. 8. cardiac ventricular arrhythmias requiring anti-arrhythmic therapy

Keywords: advanced hepatocellular carcinoma tace haic system therapy
theta burst stimulation with an 8-coil versus h1-coil for resistant depression

Conditions: Treatment of Resistant Depression; H1-Coil; Theta Burst Stimulation

Summary: the goal of this clinical trial is to compare response rates after treatment with figure eight-coil tms versus h-coil tms on the prefrontal cortex left dorsolateral, in patients suffering from depression resistant. the main question it aims to answer is: rtbs (accelerated neuronavigated intermittent theta burst stimulation) is more effective than htbs (accelerated deep intermittent theta burst stimulation) in the treatment of resistant depression in terms of response rate.? researchers will compare figure eight-coil tms (rtbs) versus h-coil tms (htbs) to see if rtbs is more effective than htbs. participants will: * receive, for each stimulation method, 8 sessions per day spaced 50 minutes apart, over 5 days. * have visit all day of stimulation for checkups and tests. * have a a research mri before and after treatment. * have follow-up visits at 1 month, 2 months, 3 months, 6 months, and 12 months post-treatment, via teleconsultation.


Eligibility criteria:
inclusion criteria: * patients over 18 years of age * presenting a major depressive episode according to the dsm-5-tr criteria, occurring as part of major depressive disorder (unipolar depression) * the major depressive episode must meet the criteria for treatment resistance, defined by a lack of response to at least two different antidepressant treatments prescribed at an effective dose for a duration of 6 weeks or more * stable treatment for at least 6 weeks * affiliation with a social security system or state medical assistance (aide médicale d'état) * patient agrees to participate in the study and has signed an informed consent form exclusion criteria: * presence of a contraindication to tms: epilepsy, intracranial foreign body, cochlear implant, retinal implant, pacemaker * presence of a bipolar disorder according to dsm-5-tr criteria * presence of catatonic or psychotic features during the current episode * presence of severe psychiatric disorders other than a major depressive episode * presence of neurological disorders * unstable epilepsy * current moderate to severe addiction disorders other than caffeine and/or tobacco * current suicidal ideation * use of any brain stimulation treatment (ect, rtms, tdcs) for the current episode * pregnancy or breastfeeding * women of childbearing potential without effective contraception * persons under guardianship or legal protection

Keywords: resistant depression h1-coil theta burst stimulation tms accelerated transcranial magnetic stimulation intermittent theta burst stimulation with an 8-coil versus h1-coil
rapid improvement of depression of fluoxetine combined with atp

Conditions: Depression

Summary: the clinical study is a randomized (1:1:1), double-blind, placebo-controlled clinical study. recruit patients with moderate to severe depression. after signing the informed consent, patients who meet the inclusion criteria will be randomly assigned to the atp group (fluoxetine combined with atp) or phosphocreatine group (fluoxetine combined with phosphocreatine) or control group (fluoxetine combined with 0.9% sodium chloride) to received treatment. then accessed scale, cognitive function and brain function before treatment and at one, two, and four weeks after treatment to initially explore the safety and efficacy of atp combined with fluoxetine to rapidly improves moderate to severe depression.


Eligibility criteria:
inclusion criteria: * meet dsm-v diagnostic criteria for moderate to severe depression. * hamd-24 scores ≥ 20. * 18-65 female or male. * subjects who have not used any antipsychotic drugs, antidepressants, mood stabilizers (sodium valproate, lithium carbonate) or fluoxetine treatment within the first month prior to the start of this study * written informed consent. exclusion criteria: * sufferring from various major mental disorders other than depression (such as bipolar disorder, schizophrenia, personality split, etc.). * individuals with neurological disorders such as dementia. * individuals with a high risk of suicide. * pregnant and lactating women. * individuals with alcohol or drug abuse or dependence within one year prior to the start of this study. * contraindications to mri. * physician evaluation was not suitable for participants in this study.
latino study: a study of mircera for the maintenance treatment of dialysis patients with chronic renal anemia.

Conditions: Anemia

Summary: this single arm study will assess the efficacy and safety of mircera when administered once monthly, subcutaneously or intravenously, for the maintenance of hemoglobin levels in dialysis patients with chronic renal anemia. patients currently receiving maintenance treatment with epoetin alfa will receive monthly injections of mircera with a starting dose (120, 200 or 360 micrograms) derived from the dose of epoetin alfa they were receiving in the week preceding study start. the anticipated time on study treatment is 3-12 months, and the target sample size is 100-500 individuals.


Eligibility criteria:
inclusion criteria: * adult patients, \>=18 years of age; * chronic renal anemia; * hemodialysis or peritoneal dialysis, with same mode of dialysis for \>=3 months before and throughout screening period; * stable maintenance epoetin alfa therapy for past 2 months. exclusion criteria: * transfusion of red blood cells during previous 2 months; * poorly controlled hypertension requiring interruption of epoetin alfa in past 6 months; * acute or chronic bleeding during previous 2 months.
hiv self-testing and long-acting injectables for hiv treatment and prevention among commercial minibus drivers (i-test lais) in nigeria

Conditions: HIV

Summary: long-acting injectable antiretroviral therapy (lai art) and pre-exposure prophylaxis (lai prep) have the potential to transform hiv treatment and prevention, especially in reaching individuals such as commercial minibus drivers who have minimal or no contact with traditional health facilities. the project proposes to use a culturally appropriate and community-engaged approach to promote the uptake of hiv self-testing, lai-art, and lai-prep among commercial minibus drivers in nigeria by engaging commercial minibus drivers as peer educators/research facilitators.

commercial minibus drivers constitute a large social network of highly mobile men who work long and demanding hours, are at increased risk for hiv, and have limited time to seek health services for hiv. in our preliminary work, our team found a high hiv seropositivity rate of 12.5% among 407 commercial minibus drivers in nigeria, a prevalence that is nine times higher than the national hiv average. despite the high willingness to test for hiv among the drivers, the mobile nature of their work poses substantial barriers for those living with hiv to initiate and adhere to antiretroviral therapy (art) and for those who are hiv-negative and are at risk for hiv to obtain pre-exposure prophylaxis (prep). therefore, innovative strategies such as hiv self-testing (hivst), which allows individuals to test at home or in private, and long-actinginjectable art (lai art) or lai prep may work better to address the barriers that impede commercial drivers from accessing hiv testing, prevention, and treatment services. our team has recently evaluated a youth-friendly hivst intervention combined with linkage to prep in nigeria as part of an nih-funded project called itest: innovative tools to expand youthfriendly hiv self-testing (uh3hd096929). we propose to leverage our established research program in nigeria in collaboration with the national institute of medical research to implement a tailored itest intervention for commercial minibus drivers (itest lais), which will include male peer-led distribution of hiv self-testing kits combined with demand creation for both oral and lai modalities of art and prep. our multi-disciplinary research team proposes a hybrid type i effectiveness-implementation study to assess clinical and implementation determinants outcomes simultaneously.

Eligibility criteria:
inclusion criteria: 1. male commercial minibus drivers who have worked as a driver for at least 6 months 2. 18 years old or older 3. currently and planning on residing in one of the lgas during the next 12 months 4. owning a mobile phone exclusion criteria: 1. known hiv positivity 2. not ability to provide informed consent3 3. no access to a cell phone

Keywords: hiv prep long-acting injectables nigeria minibus drivers
oral pyridoxal 5'-phosphate for the treatment of patients with pnpo deficiency

Conditions: Pyridox(am)Ine 5'-Phosphate Oxidase Deficiency

Summary: the proposed clinical study is intended to evaluate oral p5p for the treatment of patients confirmed to have pyridox(am)ine 5'-phosphate oxidase (pnpo) deficiency via genetic analysis. there is an unmet clinical need for pharmaceutical grade p5p, as to date none has been made commercially available. patients will receive pharmaceutical grade p5p according to their normal oral p5p dosing regimen, as previously established by their physicians.


Eligibility criteria:
inclusion criteria: 1. patients with confirmed pnpo deficiency via genetic analysis, whose seizures are typically controlled on p5p (oral) therapy. a. typically controlled is defined as receiving multiple doses of p5p daily to control seizures. receiving p5p for a minimum of 30 days. 2. male and/or female patients. 3. patients with previous failed treatment on pyridoxine are eligible for the study (patient should be off pyridoxine for at least 24 hours). 4. written informed consent (by parent or guardian if under the age of 18). exclusion criteria: 1. the patient has any condition or abnormality which may, in the opinion of the investigator, compromise the safety of the patient, or influence their ability to comply with study procedures. 2. known or suspected allergy to the trial drug or the relevant drugs given in the trial. 3. involvement in a clinical research study within 4 weeks prior to screening and/or prior enrollment in the study. participation in observational registry studies is permitted.
telemonitoring of activities of daily living in home care services of older adults with cognitive deficits

Conditions: Dementia

Summary: in canada, it is estimated that two million people are users of publicly funded home care services, with more than half of them being 65 years and older. although home care services are considered a priority by canadian provinces, in québec alone, more than 46 000 people were waiting for those services in 2022. the provision of home care services is hampered by limited funding and growing demand from among an aging population, among other factors. these challenges have led to urgent calls to better support home care in canada to ensure optimal use of scarce human and financial resources. one of the key strategies to achieve optimal use of resources may be remote monitoring of activities of daily living (adls), a type of telehealth. adl telemonitoring can remotely recognize adls such as preparing meals and moving around the home. past studies have shown that adl telemonitoring can help in better understanding older adults' home care needs, thereby allowing for more personalized adl interventions. previous projects have also allowed for the developement of nears-sapa, a telemonitoring system for adls. in these past projects, it was identified how nears-sapa was used by home care services and its ease of use was tested in real environments. in the present project, the benefits of adl telemonitoring will be tested and its technological capabilities expanded, hence preparing the system for the next big step, i.e. large-scale adoption by home care services. ultimately, adl telemonitoring may help the healthcare system determine which service is more appropriate for which person and at what time, thereby optimizing interventions and resource management.


Eligibility criteria:
inclusion criteria: 1) be an older adult (\> 65 years old), 2) have cognitive deficits as reported in the medical record, 3) live alone, at home, 4) be a care recipient of home care services, 5) speak french or english exclusion criteria: * none

Keywords: telemonitoring of adl homecare services ia
dynepo long-term safety study

Conditions: Anemia; Kidney Failure, Chronic

Summary: to assess the incidence rate of treatment emergent adverse events (teaes) over 2 years in patients treated with dynepo.


Eligibility criteria:
inclusion criteria: 1. patients who complete dynepo study spd490-301. 2. patients who continue to require epoetin (epo) treatment and have had a hb level of 10g/dl between weeks 16 and 24 of study spd490-301. exclusion criteria: 1. withdrawal, before week 24, from study spd490-301. 2. pregnant or lactating women. 3. uncontrolled hypertension. 4. thrombocytopenia (platelet count \<75,000/mm3). 5. active bleeding disorder (diathesis) (for example, gastrointestinal bleeding or genitourinary tract bleeding). 6. treatment with immunosuppressive drugs (other than corticosteroids for a chronic condition) in the 30 days immediately prior to enrolment in this study. 7. androgen therapy in the 30 days immediately prior to enrolment in this study. 8. known human immunodeficiency virus (hiv) infection. 9. history of hypersensitivity to dynepo. 10. known to have ab against epo.
a physical activity and diet program to prevent accumulation of abdominal fat mass in recently retired men and women

Conditions: Retirement; Weight Gain

Summary: advancing age in itself is associated with changes in body composition. however, during transitional life stages, such as retirement, detrimental changes on diet and physical activity may occur. this might lead to weight gain and accumulation of abdominal fat. to prevent these changes, participants receive a low-intensity intervention on energy balance and related behaviours. after six months, one and two years, the effects will be studied by comparing the intervention group with the control group.


Eligibility criteria:
inclusion criteria: * apparently healthy and recently retired exclusion criteria: * using drugs that might influence body composition, digestion or physical activities

Keywords: prevention retirement physical activity diet weight gain body composition