Kornimate/medical-research-clean huggingface dataset:
corneal oxygen uptake with apioc contact lenses

Conditions: Contact Lens-Induced Corneal Disorder of Both Eyes (Diagnosis)

Summary: the purpose of this research is to determine if a new investigational contact lens shape allows the eye to get more oxygen.


Eligibility criteria:
inclusion criteria: 1. provide informed consent. 2. appear willing and able to adhere to instructions set forth in the protocol. 3. be between the ages of 18 and 45. 4. be an experienced contact lens wearer. 5. be an eyecare clinician or clinician-in-training. 6. flat and steep keratometry readings within 40 to 50d. 7. clear, healthy corneas with no irregular astigmatism. 8. normal, healthy conjunctiva in both eyes. 9. be able to provide corneal topography measurements. 10. be able to provide manifest refraction measurements. exclusion criteria: 1. irregular corneal astigmatism. 2. use of topical or systemic antihistamines within the previous week. 3. use of topical ophthalmic drops within the previous two days. 4. history of corneal surgery. 5. currently pregnant or lactating. 6. systemic disease that would interfere with contact lens wear. 7. previous diagnosis of dry eye syndrome.
comparison of oral lactulose versus polyethylene glycol for bowel preparation in low-risk patients

Conditions: Colonic Neoplasms

Summary: adequate quality of bowel preparation(bp) is essential for colonoscopy. in recently, kang suggested that for low-risk patients, single dose of 2l peg is an effective regimen for bowel preparation.however, due to the poor palatability, there still more than 30% patients with 2l regimen experienced nausea or vomiting in our center. oral lactulose is a treatment for constipation. several studies have compared the effectiveness between use peg and lactulose for colonoscopy preparation in average-risk patients. however, the data in low-risk patients is vacant. the objective of current study was to compared the effectiveness of bowel preparation and patient tolerance using lactulose and 2l peg regimen in low-risk patients.


Eligibility criteria:
inclusion criteria: * patients over 18 years old and with low-risk were eligible. patients were considered as low risk if they did not meet any of the following risk factors: age\>70 years old, body mass index (bmi)\>25kg/m2, constipation, parkinson's disease, diabetes, history of stroke or spinal cord injury, use of tricyclic antidepressant or narcotics. exclusion criteria: * (1) history of colorectal resection; (2) known or suspected colonic stricture or obstructing tumor; (3) known or suspected colonic perforation; (4) toxic colitis or megacolon; (5) use of prokinetic agents or purgatives within 7 days; (6) hemodynamic instability; (7) pregnancy or lactation; (8) inability to provide informed consent.

Keywords: colonoscopy bowel preparation
safety and efficacy study of angiotech central venous catheter to prevent bacterial catheter colonization

Conditions: Bacterial Infections

Summary: the main purpose of this study is to determine if the angiotech central venous catheter (cvc) is equal in effectiveness to a cvc coated with chlorhexidine and silver sulfadiazine in preventing bacterial catheter colonization. other objectives of this study are to determine if the angiotech cvc is equal in effectiveness to a cvc coated with chlorhexidine and silver sulfadiazine in preventing catheter-related local infection, and catheter-related bloodstream infection. this study will also assess the safety of the angiotech cvc.

central venous catheters are widely used for hemodynamic monitoring and the administration of fluids, drugs, and nutrition. the most frequent life-threatening complication of central venous catheter use is septicemia. normal cutaneous flora may invade the intracutaneous tract during or after catheter insertion. the colonizing bacteria subsequently disseminate along the catheter surface and ultimately seed into the blood stream. in the united states, a total of 250,000 cases of central venous catheter-related infections are estimated annually. costs per infection are estimated as high as us$56,000. it is clinically imperative that effective measures be found to decrease catheter infection rates while minimizing the risk of the development of microbial resistance. primary objective: the primary objective of this study is to determine the non-inferiority of the angiotech central venous catheter (cvc) when compared to the arrowgard blue® cvc to prevent bacterial catheter colonization. secondary objectives: the secondary objectives of this study are to determine the non-inferiority of the angiotech cvc when compared to the arrowgard blue® cvc to prevent: 1. catheter-related local infection; and 2. catheter-related bloodstream infection. safety objectives: this study will assess the safety of the angiotech cvc.

Eligibility criteria:
inclusion criteria: * at least 18 years of age * be initially hospitalized in an intensive care setting * require insertion of a triple-lumen central venous catheter for an anticipated period of up to 28 days * if female and of child-bearing potential, provide evidence of a negative pregnancy test exclusion criteria: * has a life expectancy of less than one month * is pregnant * has a history of anaphylactic reactions, including reactions to contrast dyes * has a history of allergy to 5-fluorouracil (5-fu) or chlorhexidine

Keywords: colonization of the catheter catheter related bloodstream infection
mental health training for elementary teachers through tele-education and its impact on the school atmosphere

Conditions: Mental Disorders

Summary: the purpose of this study is to create a web-based interactive educational environment to train elementary teachers, to identify children and adolescents in need of specialized mental health care and give them some advises in managing problematic children in class. after the creation of such an educational environment the psychoeducational project was tested in order to verify it's effectiveness.

objectives: to develop and test the efficacy of a computer-based training to elementary school teachers of the most common mental health problems. outcomes: (a)early identification of the most common mental health problems among children and adolescents, (b)teacher's acquirement of manage skills to better deal with behavior problems and (c)teacher's acquisition of important knowledge to refer students to treatment when necessary. method: this research includes two steps: a pilot project (already implemented, whose data will be presented here) and a randomized clinical trial intervention (that will be implemented in a few months). 1. pilot project, without control group - comprehended six sessions of educational videos covering basic concepts of mental health stigma and the main disorders that affects children and adolescents followed by discussion forums, quizzes and a conclusion web conferencing with a specialist. 2. a randomized controlled trial with a sample of 176 teachers from nine elementary schools were randomly divided in three groups: a web-based interactive educational group (wbie), a text and video-based educational group (twbe) and a waiting list group (wl). outcome measures: knowledge, beliefs and attitudes of teachers in mental health and satisfaction with the training received. results: the results show that there was an increase in knowledge, attitude changes in mental health and reducing stigma among teachers of web-based interactive educational group. indeed, comparing the three groups of study participants (wbie, tvbe and wl), was verified that tvbe group compared with wl group did not show a significant statistical difference (b = 0.957, p = 0.127). comparing wbie with wl group, the wbie answers correctly 1:44 (b = 1.44, p = 0.015). regarding beliefs and attitudes, wbie group increased significantly in the ability to identify children with mental health problems, search for mental health information, the ability to recognize colleagues with mental health problems. the average confidence in helping a student with mental health problems also showed increased after psychoeducational intervention in wbie group. discussion: after adjusting educational tools, the methodology and with a bigger sample it's expected to have greater positive results. it's very important to offer teachers a basic apparatus so that they will be able to deal with mental health issues in schools.

Eligibility criteria:
inclusion criteria: * primary public schools of campos do jordão city * internet access exclusion criteria: * none

Keywords: effectiveness distance learning mental health
observational study to assess natural history in cockayne syndrome patients

Conditions: Cockayne Syndrome

Summary: this is an observational study of children under the age of 11 diagnosed with cockayne syndrome to assess the natural progression of cockayne syndrome disease, with special attention to hearing and physical changes in length or height, weight, head circumference, and arm span during standard treatment. the primary analytical objective is to determine the rate of linear growth over a 6-month period in children \< 2 years of age and over a 12-month period in children ≥ 2 years of age.


Eligibility criteria:
inclusion criteria: * pediatric patients with a documented diagnosis of cs, as suggested by clinical features and possible confirmation by genetic consultation and analysis * age of participation: * at least 12 months of age at the time of signing informed consent/assent * female patient's age will not be greater than 10 years of age at the time of signing informed consent/assent * male patient's age will not be greater than 11 years of age at the time of signing informed consent/assent exclusion criteria: * severe contractures or physical deformities that in the opinion of the investigator would prevent accurate measurement of height, length and ulna length * patients that have taken growth hormone or growth hormone related medications within 12 months prior to the date of informed consent/assent * known history of inborn error of hyperprolinemia (type i or type ii) * clinical features present at the time of initial screening that are associated with the terminal phases of the natural progression of cs suggesting safe travel and completion of the study and its assessments to be unlikely as judged by the investigator, including any of the following: * continuous or intermittent dependence on supplemental oxygen at home during the prior six months * two or more hospitalizations for pneumonia during the prior 12 months; * a documented net weight loss of at least 10%, which has not been recovered and which includes a significant net weight loss (beyond the estimated error of the measurement) over the most recent 6 months, despite intensive nutritional support including the use of gastrostomy tube feedings * presence of scoliosis with a cobb's angle of 30º or greater

Keywords: cockayne syndrome pediatrics growth hearing ageing
genetic frontotemporal dementia initiative for neurodevelopment

Conditions: Frontotemporal Dementia; Family Members

Summary: this is an international multi-centre cohort study of first and second degree family members of individuals who carry frontotemporal dementia (ftd) mutations in mapt, grn or c9orf72 repeat expansions for youths between the ages 9-17.

genfi-neurodev will study genetic ftd and its associated disorders (including motor neurone disease (mnd)/amyotrophic lateral sclerosis(als)) in members of families with a known mutation in grn or mapt or an expansion in c9orf72. participants with at-risk members of families (first-degree and second-degree relatives of known genetic mutation carriers). all genfi-neurodev participants will be assessed longitudinally with a set of clinical, neuropsychiatric, cognitive, imaging and biosample protocols. parents or guardians of potential genfi neurodev participants are all aware of the autosomal dominant genetic nature of ftd in their family prior to being approached for potential participation in this study.

Eligibility criteria:
inclusion criteria: 1. written informed consent must be obtained and documented (from the participant and their substitute decision maker). this can be obtained in person or remotely. 2. youths between the ages of 9 and 16 inclusive at time of enrollment, followed until age 17. 3. youths must have a 1st or 2nd degree biological relative who has participated (past or present) in the genetic frontotemporal dementia initiative (genfi) study or with genetic ftd (i.e. a known mutation in biological parent or grandparent). 4. parent(s)/guardian deem appropriate to participate. 5. must have a study partner who can participate as required in the protocol (provide corroborative information). study partner must have regular contact with the participant and must be parent/guardian of this participant. 6. must have age-appropriate awareness that ftd runs in their family as determined by local pi. exclusion criteria: 1. current structural brain abnormality affecting cognition or behaviour not thought to be possibly related to genetic ftd that would prevent completion of study assessments (such as brain tumor, stroke, hydrocephalus). 2. other concerns that participation in the study may not be in the best interest of the youth or parent, as raised by the participant's parent/guardian/primary care provider, local site pi or psychologist. 3. lack of study partner. 4. for mri: meeting any mri incompatible criteria. note: participants may opt to decline mri scans and complete the other measures.
turkish lower-extremity motor activity log (le-mal)

Conditions: Stroke; Spastic Paraplegia

Summary: the motor activity log was developed to measure paretic upper extremity use in daily activities in the real-life context (real world) of people with different health conditions, including stroke. subsequently, the lower extremity motor activity diary was developed. this survey is a semi-structured survey in which the participant is asked to rate himself/herself according to each scale over 14 activities.

the motor activity log was developed to measure paretic upper extremity use in daily activities in the real-life context (real world) of people with different health conditions, including stroke. real-world use outside the individual's clinical/laboratory environment, including daily activities (e.g., walking indoors and outdoors above ground, climbing stairs, getting in and out of a car, jumping over an object, picking up an object, sitting and standing) it's about what they do. the motor activity log is a reliable patient self-report measure and correlates significantly with another real-world measure, the accelerometer. adaptation of the motor activity log to the lower extremity involved the development of three subscales to measure changes in types of activity that are bilateral in nature and use of the paretic lower extremity: level of assistance, functional ability, and confidence. the lower extremity motor activity log is a semi-structured questionnaire in which the participant is asked to rate himself on each scale across 14 activities. the score for each scale is the average of the rate provided for each activity. additionally, a composite score can be calculated that combines all scales through assistance, functional ability, and confidence scores. a preliminary study with individuals with stroke using the english version of the lower extremity motor activity log-14 showed that the total score was 0.93, 0.90, 0.94, and 0.88 test-retest for the composite score, assistance, functional ability, and confidence scales, respectively. the test showed that it has reliability. the aim of this study is to investigate the reliability and validity of the turkish version of the lower extremity motor activity log-14.

Eligibility criteria:
inclusion criteria: * individuals between the ages of 18-80 living in gaziantep who applied to the neurology outpatient clinic of hospital and were diagnosed with stroke. exclusion criteria: * patients with a history of trauma within the last year, alcohol and substance addiction, and pregnancy

Keywords: le-mal spasticity measurement validity reliability
neuropsychological consultation as part of pediatric diabetes care: does it improve glycemic control and family functioning?

Conditions: Diabetes; Glycinemia

Summary: this is a randomized controlled open label study design (study team will not be blinded) to measure whether including targeted neuropsychological consultations as part of pediatric diabetes care informs treatment and educational planning, improves glycemic control, and improves quality of life. patients will be randomized 1:1 ratio to group 1-control group and group 2-neuropsychological consultation group.


Eligibility criteria:
inclusion criteria: * diagnosed with type 1 diabetes and followed for their care at the nyu pediatric diabetes center * english speaking families exclusion criteria: * not english speaking * diagnosed with type 1 diabetes within the last 6 months
a study to evaluate the efficacy and safety of qlf31907 combination therapy in patients with advanced malignant tumors

Conditions: Advanced Malignant Neoplasm

Summary: this study is designed to evaluate the safety and efficacy of qlf31907 combination therapy in advanced malignant tumors.


Eligibility criteria:
inclusion criteria: 1. subjects voluntarily participated and signed a written informed consent form; 2. age ≥18 years, male or female; 3. ecog ps 0-1; 4. histopathologically diagnosed advanced malignant tumors; 5. at least 1 measurable lesion according to recist v1.1 criteria or lugano (2014) criteria; 6. adequate organ function; exclusion criteria: 1. previous treatment with 4-1bb agonist or 4-1bb recombinant fusion protein; 2. received anti-tumor therapy within 4 weeks prior to the first study treatment; 3. history of autoimmune disease; 4. history of other active malignancies within 3 years prior to the first treatment; 5. history of serous cardiovascular events;
evaluation of commonly used blood glucose meters in vietnam

Conditions: Pregnancy in Diabetic; Diabetes

Summary: rationale: most bgm (blood glucose monitoring) devices in vietnam are manufactured for home use only. however, they are commonly used in healthcare facility, primarily at point of care. we want to assess the validity of these devices by using clsi (clinical and laboratory standards institute) poct12-a3 to assess the accuracy. objective: to validate the accuracy and effect of hematocrit on these devices, along with the precision profile using clsi ep15a3 study design: this is a cross-sectional study. study population: because we need a wide range of blood glucose level. we chose pregnant women who underwent 75g glucose tolerance test.

most blood glucose monitors circulating the market are manufactured after iso 15197:2013 standard, which is intended for self-measurement. medical organizations need to verify blood glucose monitors if they are designed for prescription point-of-care use or validate blood glucose monitors if they are designed for over-the-counter use. pregnant women are selected after consent, their blood are then drawn by phlebotomist into an edta (ethylenediamine tetraacetic acid) with naf (sodium flouride) blood tube. samples are run on alinity h hematology analyzer, manufactured by abbott, to measure hematocrit. the analyzers are verified by laboratory procedure, recommended by clsi (clinical and laboratory standards institute) method and quality control is checked before in accordance to the laboratory procedure. after that, blood tube is mixed thoroughly before being pipetted. each bgm device will measure blood glucose level of the pipetted whole blood. finally, samples will be run on a cobas c 502 analyzer to measure plasma glucose level, which is a reference method for determining the accuracy of the bgm devices. statistical analysis: meter performance is acceptable for use in hospitals when 95% of the individual results from the poc glucose meter system agree within 0.67 mmol/l (12 mg/dl) of the laboratory analyzer values at glucose concentrations below 5.55 mmol/l (100 mg/dl) and within 12.5% of the laboratory analyzer values at glucose concentrations at or above 5.55 mmol/l (100 mg/dl). in addition, the sum of the number of individual results with 1) errors that exceed 0.83 mmol/l (15 mg/dl) at glucose concentrations below 4.2 mmol/l (75 mg/dl) and 2) errors that exceed 20% at glucose concentrations at or above 4.2 mmol/l (75 mg/dl) should not exceed 2% of all results. an ordinary linear regression is performed to see how well the glucose level of bgm devices correlates with the reference method. bland-altman difference plots are used to describe the difference along with the hematocrit of each sample.

Eligibility criteria:
inclusion criteria: * pregnant women undergo 75g glucose tolerance test exclusion criteria: * usage of anticoagulant drug * history of bleeding disorders.
assessment of mobilization cost for multiple myeloma using 2 different mobilization strategies

Conditions: Multiple Myeloma; Blood Stem Cell Transplant Failure

Summary: this is a retrospective observational cohort database analysis. the study will review retrospectively the records of patients undergoing a first peripheral blood stem cell mobilization for multiple myeloma in the databases from approximately 15 hospitals which are part of the ifm collaborative group. patient records will be divided into two groups of 50 patients minimum, maximum 100 patients or up to the number of patient records that could be extracted. the first group of patients will have received plerixafor plus g-csf without the administration of chemotherapy as a mobilization strategy and a second group of patients will have received cyclophosphamide plus g-csf as a mobilization strategy. all consecutive patients with complete set of data (and who underwent apheresis) treated between 2009 and 2013 with g-csf and plerixafor and all consecutive patients with complete data (and who underwent apheresis) treated between 2009 and 2013 with g-csf and cyclophosphamide will be included. all data that will be analyzed will be extracted from the selected ifm institutions which are located in france.


Eligibility criteria:
inclusion criteria: * hematology patients diagnosed with multiple myeloma who are candidates for autologous hematopoietic stem cell transplantation (asct) upfront. * age \> 18 years * undergone prior successful peripheral blood stem cell mobilization with cyclophosphamid or plerixafor exclusion criteria: * age \< 18 years; * primary diagnosis other than multiple myeloma
a pilot study of sildenafil in covid-19

Conditions: COVID-19

Summary: observe the efficacy and safety of g1(sildenafil citrate tablets) in patients with covid-19 under clinical actual diagnosis and treatment conditions


Eligibility criteria:
inclusion criteria: 1. patients diagnosed as covid-19: 1. mild patient: fever,respiratory and other symptoms, the manifestation of pneumonia can be seen on imaging. 2. severe patients: meet the definition of severe pneumonia(comply with any of the followings): shortness of breath,rr≥30 bpm;in a resting state:spo2≤93%;pao2/fio2≤300mmhg. 2. age≥18 years old,unlimited gender. 3. patients who cannot stop the following drugs during the trial:erythromycin or strong inhibitors of cyp3a4 (such as saquinavir,ketoconazole,itraconazole),nonspecific inhibitors of cyp (such as cimetidine),hiv protease inhibitors (such as ritonavir). 4. willing to participate in this study,signed informed consent and willing to participate in regular follow-up during the study. exclusion criteria: 1. suffer from severe cognitive impairment or mental illness. 2. pregnant and lactating women. 3. patients taking nitric oxide drugs and nitrates in any dosage form. 4. patients with malignant tumors;ami, stroke or life-threatening arrhythmias within 6 months;hereditary pigmented retinitis;heart failure or unstable angina pectoris of coronary heart disease;patients with severe hypotension and hypertension. 5. patients who are allergic to the study drug or the researcher believes it is not appropriate. 6. participate in other clinical studies at the same time.