Kornimate/medical-research-clean huggingface dataset:
prehospital study at the universitair ziekenhuis brussel ii

Conditions: Stroke

Summary: interventional prospective randomized open blinded end-point (probe) single-center clinical trial on the evaluation of the efficacy, safety, feasibility, reliability, and cost-effectiveness of in-ambulance telemedicine for patients with suspicion of acute stroke.

the purpose of pressub ii is to evaluate the efficacy, safety, feasibility, reliability and cost-effectiveness of in-ambulance telemedicine during paramedic intervention team transportation of patients with suspicion of acute stroke. the implementation of expert stroke support in the pre-hospital arena using in-ambulance telemedicine is an innovative approach that opens up new perspectives and allows continuous guidance by a stroke specialist throughout the acute stroke care continuum.

Eligibility criteria:
inclusion criteria: * emergency transportation by the paramedic intervention team of the universitair ziekenhuis brussel * age \>= 18 years * suspicion of acute stroke with symptom onset \< 12 h or unknown, based on any of the symptoms mentioned in the belgian manual for medical regulation of pre-hospital care: hemiparesis, facial asymmetry, speech disturbance, sudden, severe headache, or confusion. exclusion criteria: * patients for whom in-ambulance telemedicine consultation would delay any diagnostic or therapeutic intervention.

Keywords: telemedicine prehospital emergency medicine stroke
improving muscle assessment in older adults - the "can we build a better mouse trap?" study

Conditions: Sarcopenia

Summary: the primary aim of this study is to compare traditional muscle function tests with computerized versions using body-worn motion sensors and video motion analysis of the same tests. the investigators selected the timed up and go (tug) test as the investigators primary variable for this aim with several other function tests (e.g., repeated chair rise, 6-meter walk, 2-minute walk, romberg stance, semi-tandem / tandem stance) as secondary variables. the investigators primary hypothesis is that the computerized versions of the tug test are highly correlated (\>0.9) with the traditional method, but with comparable or better reproducibility. secondary analyses will correlate other function tests with their computerized version, again with the hypothesis that they are highly correlated and that computerized versions are of similar or better reproducibility. this analysis will also compare traditional assessments of balance with a computerized balance method, computerized dynamic posturography.


Eligibility criteria:
inclusion criteria: 1. ambulatory, community dwelling men and women age ≥ 70 years 2. able and willing to sign informed consent 3. able to stand without assistance exclusion criteria: 1. history of myocardial infarction within the prior six months or ongoing angina 2. history of injury or surgery within the prior six months which limits the ability to ambulate 3. history of malignancy with metastasis to the musculoskeletal system 4. neuromuscular disease or severe end organ disease impairing balance or muscle function to the degree that completion of all study tests is unlikely.

Keywords: sarcopenia, muscles, aging
evaluating cbt delivered by community health workers on maternal mental health and infant cognitive development in insecure environments

Conditions: Maternal Anxiety; Maternal Depression; Infant Cognitive Development

Summary: this study evaluates a cognitive behavioral therapy intervention for mothers with symptoms of anxiety and depression living in insecure environments using a randomized controlled methodology. key outcomes of interest include maternal mental health and infant cognitive development. the intervention will be delivered by community mental health workers who will be trained to administer 8 to 12 cognitive behavioral therapy sessions.


Eligibility criteria:
inclusion criteria: * women in their third trimester of pregnancy * who exhibited symptoms of anxiety and depression exclusion criteria: * women who express suicidality
cardiac surgery recovery in infants assessed using neoneur feeding system

Conditions: Neonatal Disease; Post-Surgical Complication; Cardiac Disease

Summary: a prospective non-randomized longitudinal design of 30-40 infants from initiation of oral feeding until discharge to track feeding changes as a potential indicator of surgical recovery.

safe oral feeding is a challenge for infants born with complex congenital heart disease (chd). these infants are likely to require tube-assisted feeding at the initiation of enteral feeding and struggle to transition to full oral feeding. infant post-surgery recovery includes a safe transition to oral feeding without respiratory risk. neoneur feeding system, consists of a novel hand-held, mobile phone application, and a cloud based computation, which innovatively measures patterns of oral cavity pressure synchronized with respiration, providing a quantitative assessment of feeding patterns. yet there has been no quantitative means of measuring this recovery process. the concept of post-surgical recovery model is not new. the adult literature is replete with physiologic and behavioral indicators of recovery. more recently roy and colleagues introduced a recovery model for post-surgical chd children to adults using a component metrics of physiologic parameters. we are proposing to develop an infant specific recovery model using feeding patterns using data generated by the neoneur device. the model, using the lens of behavioral organization, will include feeding measurements from initiation of oral feeding to discharge. this study will evaluate the association between feeding recovery and clinical assessment of infant behaviors as measured in a brief survey to assess irritability, ability to be soothed, alertness, non-nutritive sucking, and muscle tone. forty infants will be recruited from the pcicu-csd at musc to capture thirty usable infant sets of neoneur data from the pcicu-csd at musc. this data will be assessed using the neoneur feeding system to create a model of feeding recovery.

Eligibility criteria:
inclusion criteria: * complex congenital heart disease requiring cardiac surgery during first month of life * gestational age\>=35 weeks at birth exclusion criteria: * no other major non-cardiac congenital anomalies, * no history of major neurologic insult * not listed for a heart transplant, * not intubated for \>4 weeks post-surgery, * not trisomy 13, 18, and 21 * no cleft lip/palate.

Keywords: recovery
simple bone cysts in kids

Conditions: Bone Cyst

Summary: simple bone cysts (sbcs) are cysts filled with fluid that occur most frequently in the long bones (arms or legs) of children. there are many ways to treat sbcs but it is unclear if one is better than another. the purpose of this research trial is to compare the effectiveness of two common treatments that are used by surgeons today.

in general, few randomized clinical trials have been undertaken in paediatric orthopaedics, and only one to date has addressed the problem of simple bone cysts (sbcs). also known as unicameral bone cysts, they are the commonest bone lesion in children. despite general opinion, these cysts do not resolve at skeletal maturity. many forms of treatment have been recommended but none, including the popular methods of corticosteroid or bone marrow injections, have reliably eradicated sbc. although the lesions are considered benign (non-cancerous), they cause pain, frequently interfere with function, dramatically restrict play activity, may re-fracture leading to growth arrest and/or deformity, and cause enormous anxiety for children and their families. with a well-developed network of surgeons and researchers, we will provide evidence comparing the effectiveness of two treatment interventions for sbc. more specifically, our goals for this study are: 1. to compare the rate of radiographic healing between two standard treatments including curettage with puncture alone, and curettage with puncture followed by injection with vitoss morsels; 2. to identify prognostic radiographic factors associated with simple bone cyst healing and fracture; 3. to determine the impact of simple bone cyst on children/family functioning.

Eligibility criteria:
inclusion criteria: * patients with a confirmed simple bone cyst in a long bone (ie. arm or leg) within last 3 months * at least 3 weeks must have elapsed since last fracture * at least 3 months must have elapsed since last cyst treatment * patients and/or their legal representatives willing to provide written informed consent (and assent, when appropriate) * patients with stabilizing implants in the bone where the cyst is located exclusion criteria: * patients with bone disease (ie. osteogenesis imperfecta, cancer, osteoporosis, paget's disease) * pregnant or breastfeeding female * patients with cysts crossing the growth plate (area where bone grows)

Keywords: simple bone cyst unicameral bone cyst
biological markers and advanced imaging for prostate cancer progression in active surveillance

Conditions: Low-Risk Prostate Cancer

Summary: this study aims to identify patients with low-risk prostate cancer (isup grade group 1) eligible for active surveillance who are at higher risk of upgrading to isup grade group 2 or higher at confirmatory biopsy one year after diagnosis. patients with low-risk isup gg1 tumors will be selected and undergo: * psma pet with calculation of suvmax and primary-likert score * whole exome sequencing (wes) analysis on diagnostic prostate biopsies * immunohistochemistry on diagnostic prostate biopsies * confirmatory biopsy one year after diagnosis, as recommended by international guidelines this prospective, monocentric, single-arm interventional study will assess the predictive accuracy of a multivariable model integrating next-generation imaging and molecular biomarkers to improve risk stratification in active surveillance patients.


Eligibility criteria:
inclusion criteria: * histologically proven low-risk pca (psa ≤10 ng/ml; clinical stage ≤t2a, and biopsy isup gg 1) * non-metastatic status at study inclusion (patient enrollment). * no prior or concomitant androgen deprivation therapy * ability to understand a written informed consent and willingness to sign it. exclusion criteria: * unable to tolerate a psma-pet scan * unwillingness to be managed with as * receipt of neoadjuvant or curative-intent therapies * pacemaker * inability to obtain the ffpe prostate biopsy specimens from the initial biopsy
nutrition, body composition, and sleep

Conditions: Sleep; Body Composition; Strength; Insulin Sensitivity; Energy Expenditure

Summary: the purpose of the research is to determine if protein and omega-3 fatty acid supplementation improve sleep, improve body composition, and improve markers of metabolic health in postmenopausal women.


Eligibility criteria:
inclusion criteria: - postmenopausal women (12+ months following last reported menstrual cycle) exclusion criteria: * food allergies * diet restrictions * do not habitually eat breakfast * picky eaters\\regularly consume protein or omega-3 related supplements * consume omega-3 fatty acid rich fish (tuna, salmon, etc.) greater than two times per month -have any other diet-related conditions that would prevent them from consuming whey protein supplements and/or omega-3 fatty acid supplements * smoking * habitual alcohol consumption (\> 4 drinks/week) * medication impacting appetite or metabolism * lipid or blood pressure lowering medication * hormone replacement therapy
black adult resilience study

Conditions: Alcohol Use; Cannabis Use

Summary: alcohol and cannabis are the most misused psychoactive substances in the united states, and their misuse among african american young adults has the potential to be especially problematic. the proposed research examines how daily and racial stressors (e.g., racism and discrimination) may lead to alcohol and cannabis use among african american young adults, and what individual and community coping and resources mitigate this causal effect. this research is designed to identify possible targets for culturally responsive prevention and treatment efforts to help prevent and reduce alcohol and cannabis use among african american young adults.


Eligibility criteria:
inclusion criteria: * identify as black, african american, or afro-caribbean * proficient in english * alcohol and/or cannabis use at least 4 times in past month * endorse having used alcohol and/or cannabis to cope exclusion criteria: * having participated in similar studies by the research team * obtain cut-off scores on measures indicating possible alcohol and/or cannabis use disorder * in or seeking treatment for alcohol and/or cannabis use disorder
music and symptom relief in radiotherapy patient

Conditions: Music Therapy

Summary: this randomized controlled study aims to evaluate the effects of music therapy administered during radiotherapy sessions on pain, stress, and anxiety levels in cancer patients. the intervention involves playing musicure, a therapeutic music track, for 30 minutes via speakers during radiotherapy. the study includes two groups: an intervention group receiving music therapy and a control group receiving standard care without music. participants' pain levels were assessed using the visual analog scale (vas), while anxiety and stress levels were measured using the face anxıety subscale ( fas). a total of 120 adult cancer patients undergoing outpatient radiotherapy at tınaztepe unıversty were included. the study was conducted under the supervision of dr. öğr. üyesi \[duygu akbaş uysal (principal investigator) and co-researchers prof.dr fsun şenuzun aykar, prof.dr zümra aricak alicikuş the research complies with ethical standards and has received approval from \[insert name of ethics committee\]. this study investigates a low-cost, non-pharmacological intervention that has the potential to improve symptom management and quality of life in cancer patients.


Eligibility criteria:
inclusion criteria: * volunteer to participate in the study, * 18 years of age and older, * no hearing problems, * no communication and speech problems exclusion criteria: * those diagnosed with psychiatric and neurological diseases,
bortezomib as first salvage therapy for myeloma patients previously exposed to bortezomib as initial treatment.

Conditions: Multiple Myeloma

Summary: this observational, non-interventional, retrospective, multicenter, national study focuses on collecting information about the effectiveness and safety of bortezomib re-use at first relapse in mm patients already treated in their first line with a bortezomib-based regimen, re-challenged with the same drug according to current clinical practice and/or italian sie/sies/gitmo, imwg and/or nccn guidelines/treatment recommendations. data will be collected retrospectively from approximately 25 haematologic/oncologic sites in italy. approximately, data of up to 100 patients will be collected.


Eligibility criteria:
inclusion criteria: patients satisfying all of the following criteria will be enclosed in the study: * age ≥ 18 years old * patients with documented multiple myeloma that received bortezomib-based regimens as first line treatment (both in clinical practice or clinical trials) even if followed by asct (autologous stem cell transplantation) and that after their first line treatment's clinical or biochemical relapse received again a bortezomib-based treatment according to current clinical practice and/or italian societies of hematology (sie), experimental hematology (sies) and transplantation (gitmo), international myeloma working group (imwg) and/or national cancer comprehensive cancer network (nccn) guidelines/treatment recommendations. * signed informed consent form if feasible exclusion criteria: * patients not treated with bortezomib as first line therapy and/or second line therapy * patients with more than one relapse before bortezomib re-use * patients unable to understand and sign informed consent form (see exceptions listed in section 8 "informed consent") * patients who received bortezomib at relapse in combination with any investigational drug not-approved.

Keywords: multiple myeloma bortezomib relapsed multiple myeloma rechallenge
emg biofeedback training to improve balance in individuals with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: the goal of this clinical trial is to test the impact of a novel dual-task emg biofeedback training method for improving balance in individuals living with multiple sclerosis. the main question\[s\] it aims to answer are: * does dual-task emg biofeedback training deliver lasting balance benefits up to 3 months following the intervention? * are the benefits greater than those for participation in traditional balance training exercises? * do the benefits vary with the severity of disability? participants will receive either emg biofeedback (emg-bf) training or traditional balance exercise (bal-ex) training. both treatments involve three 30-minute sessions of the training every week for 6 weeks (18 sessions). during the sessions, participants in the emg-bf treatment group will perform targeted exercises using feedback from adhesive (sticker) sensors on their arms and legs. participants in the bal-ex treatment group will following an instructor through balance training movements that are traditionally prescribed by physiotherapists to improve balance. measurements will be taken at the beginning of the study, after six weeks of training, and three months after the end of training. researchers will compare the groups to see if balance and related outcomes are improved more by 6-weeks of emg-bf training than bal-ex.


Eligibility criteria:
inclusion criteria: * adults aged 18-80 years with a formal diagnosis of ms. * participants must be ambulatory and report problems with walking and/or balance. * have stable disease with no relapses in the last 3 months. * agreement to not introduce or change the dosage of pharmaceutical treatments during the study period. this includes intramuscular injections (e.g., botox), intravenous, and orally administered drugs. * agreement to maintain the frequency, duration and intensity of physical therapy or any alternate therapies (e.g., massage, osteopathic, chiropractic, etc.) for the duration of the trial. exclusion criteria: * unable to follow instructions due to cognitive deficit or language barrier * presence of visual disorders that prevent meaningful interaction with the intervention interface. * unable to maintain stable pharmaceutical treatment for the duration of the study. * unable to maintain the frequency, duration and intensity of physical therapy or alternate therapies outside of the trial for the duration of the trial. * received botox treatment within 3 months of the onset of the study.

Keywords: balance falls
iris-synergy cohort in the iris-des registry

Conditions: Coronary Artery Disease

Summary: the purpose of this study is to evaluate the relative effectiveness and safety of synergy stent compared to other drug eluting stents.


Eligibility criteria:
inclusion criteria: * age 19 and more * intervention with synergy stent * agreed with written informed consent form exclusion criteria: * intervention with synergy stent and other drug eluting stent at the same time * life expectancy of 1year and under * cardiac shock

Keywords: drug eluting stent percutaneous coronary intervention real world
hypofractionated imrt with temozolomide for hgg

Conditions: Glioma

Summary: to evaluate safety and feasibility of hypofractionated imrt in addition to chemotherapy, concomitant and adjuvant, in patients with newly diagnosed hggs after surgery. primary endpoint: progression free survival (pfs), overall survival (os) and toxicity. secondary endpoint: to evaluate quality of life (qol) of patients after surgery, concomitant chemoradiotherapy and adjuvant chemotherapy through neuropsychological examination.

we designed a study of a hypofractionated intensity modulated radiation therapy (imrt), using vmat rapidarc approach. the potential advantage of this approach is to deliver a more selective irradiation to tumor's target with reducing dose to normal brain and to allow to deliver a higher dose, optimizing the therapeutic window

Eligibility criteria:
inclusion criteria: * age 18 to 70 years * karnosky performance status (kps) ≥60 * patients aged \>70 years with kps ≥80 * histopathologically confirmed of hgg * estimated survival ≥ 3 months. * multifocal tumor * normal liver, kidney and bone marrow function * written informed consent exclusion criteria: * prior radiation therapy * kps ≤ 60 * age \> 70 years and kps \< 70 * other primary cancer * pregnant women
validation of a smartphone-based intelligent diagnosis and measurement for strabismus

Conditions: Strabismus; Exotropia; Esotropia; Vertical Strabismus

Summary: the current measurement methods of strabismus include the corneal light reflection method, prism alternate covering, etc., which especially rely on the subjective experience of doctors, and there is a large error between different measurers， leading to serious underestimation of strabismus prevalence and insufficient care for strabismus patients. here, the investigators established and validated an artificial intelligence system to achieve an automatic diagnosis of strabismus based on patient-sourced videos of programmatic cover tests. three-dimensional reconstruction methods are used to digitize the parameters of head and eye positions. this system has been integrated into a smartphone platform to be further validated through hospital-based and population-based clinical trials.


Eligibility criteria:
inclusion criteria: the quality of facial videos should be clinically acceptable.

Keywords: mobile health artificaial intelligence medicine pediatric ophthalmology
a brain imaging study of tai chi on fibromyalgia

Conditions: Fibromyalgia

Summary: to accomplish our specific aims, we propose to conduct a two-session fmri experiment in up to 30 patients with fibromyalgia (fm) and up to 30 healthy controls. all subjects will be invited to complete the second, identical fmri session about 3 months following completion of the first session. fibromyalgia subjects will complete their scans before and after a 12-week tai chi intervention in collaboration with tufts medical center.


Eligibility criteria:
criteria for fibromyalgia patients. inclusion criteria: * volunteers 18-50 years of age. * fibromyalgia for at least the past 3 months, as determined by the referring physician. * at least a 10th grade english-reading level; english can be a second language provided that the patients feel they understand all the questions used in the assessment measures. exclusion criteria: * specific causes of pain (e.g., cancer, fractures, spinal stenosis, infections) * history of cardiac, respiratory, or nervous system disease that, in the investigator's judgment, precludes participation in the study because of a heightened potential for adverse outcome. * presence of any contraindications to fmri scanning. for example: cardiac pacemaker, metal implants, fear of closed spaces, pregnancy. criteria for healthy adults. inclusion criteria: * volunteers 18-50 years of age. * at least a 10th grade english-reading level; english can be a second language provided that the patients feel they understand all the questions used in the assessment measures. exclusion criteria: * chronic and acute pain (ex. fibromyalgia). * history of cardiac, respiratory, or nervous system disease that, in the investigator's judgment, precludes participation in the study because of a heightened potential for adverse outcome. * presence of any contraindications to fmri scanning. for example: cardiac pacemaker, metal implants, fear of closed spaces, pregnancy.

Keywords: fmri