Kornimate/medical-research-clean huggingface dataset:
pediatric intubation by nurses

Conditions: Intubation; Cardiac Arrest

Summary: the purpose of this study was to compare the pentax aws, intubrite and airtraq to miller laryngoscope during pediatric resuscitation with and without chest compressions.

endotracheal intubation (eti) is a life-saving procedure performed daily in emergency medicine. the european resuscitation council (erc) 2010 cardiopulmonary resuscitation (cpr) guidelines suggest that intubators should be able to secure the airway without interrupting chest compression. however, eti with uninterrupted chest compression in patients can be a very difficult skill to acquire.

Eligibility criteria:
inclusion criteria: * give voluntary consent to participate in the study * minimum 1 year of work experience in emergency medicine * experienced emergency medical personnel - nurses exclusion criteria: * not meet the above criteria * wrist or low back diseases
advanced sperm selection techniques and their contribution to blastocyst euploidy rates

Conditions: Sperm DNA Fragmentation; Infertility

Summary: comparing different advanced sperm selection techniques like physiological icsi (picsi) and magnetic activated cell sorting (macs) in terms of the pgt-a outcomes of each arm blastocysts

advanced sperm selection methods like picsi and macs have been developed for selecting a healthy mature non apoptotic sperm with lower sperm dna fragmentation. previous studies compared the pre-implantation embryo development parameters of those techniques, but none looked at comparing the pgt-a results or euploidy rates of the blastocysts derived from each sperm selection. pgt-a cases will be randomized on the day of icsi to the 2 assigned sperm selection techniques.

Eligibility criteria:
inclusion criteria: * case must have pgt-a for all of her blastocysts * males diagnosed with abnormal sperm dna fragmentation index (\> 20%). * normo responder (\> 5 mature oocytes) * male will have to refrain from ejaculation no less than 1 day but no greater than 3 days prior semen specimen production on day of icsi exclusion criteria: * leukocytospermia * presence of varicocele. * known genetic abnormality * use of sperm or oocyte donors * use of gestational carrier * presence of any of the endometrial factors that affect embryo implantation such as hydrosalpings, adenomyosis or previous uterine infection * any contradictions to undergoing in vitro fertilization or gonadotropin stimulation

Keywords: sperm selection picsi macs sperm dna fragmentation pgt-a euploidy rate
effect of vitamin d3 on cardiovascular risk factors

Conditions: Hypertensive Disease; Deficiency of Vitamin D3

Summary: the aim of this study is to investigate whether a supplementation of vitamin d3 can be used to reduce atherosclerotic risk factors.

it is the objective of this study to investigate whether a supplementation with vitamin d3 can be used to reduce atherosclerotic risk factors such as hypertension, inflammation and hyperlipidemia. the research question is whether vitamin d3 can lower blood pressure in mildly hypertensive subjects who are naive to antihypertensive medication, whether vitamin d reduces the level of systemic inflammation and whether vitamin d3 has an effect on blood lipids. major outcomes: - decrease of systolic blood pressure in the treatment group in comparison with the placebo group

Eligibility criteria:
inclusion criteria: * human volunteers with mild hypertension exclusion criteria: * use of antihypertensive medication * use of vitamin d or calcium supplements * known renal, inflammatory or malignant diseases * hypercalcemia or hypercalciuria * participation in other clinical studies * use of tanning booths during the study
smart trial: intrapersonal and interpersonal stigma reduction

Conditions: Stigma, Social; Opioid Use; Opioid-use Disorder; Substance Use Disorders

Summary: the goal of this project is to develop a multicomponent stigma reduction intervention to address intrapersonal (individual) stigma regarding opioid use disorder (oud). the intervention will address this cost/benefit evaluation among individuals known to face intersecting stigma of oud and african american race, with treatment elements chosen explicitly to increase the value of treatment using salient forms of reward, and to ease perceived costs through explicit services in an effort to encourage the occurrence of the first treatment visit for oud.


Eligibility criteria:
inclusion criteria: * 18 years of age or older * identify as african american, black, or mixed race * identify as someone with a substance use disorder who is not currently in treatment or a support person of someone enrolled * access to a telephone for follow-up assessment * reside in the memphis, tn area exclusion criteria: * unable to understand consent procedures

Keywords: opioid use disorder substance use disorder stigma
ex-vivo ultrasound guided radiofrequency ablation on pancreatic solid lesions

Conditions: Pancreatic Cancer; Endoscopic Ultrasound; Radiofrequency Ablation

Summary: the study investigates the feasibility and the efficacy to treat pancreatic solid lesions as pancreatic adenocarcinomas (pdac) and neuroendocrine tumors (net) with ex-vivo radiofrequency ablation (rfa) under ultrasound (us) control. the study intent is to define the optimal radiofrequency ablation power of the system in terms of maximum sizes (diameters) of histological coagulative necrosis obtained at pathological samples. results will be useful to define the optimal settings to ablate pancreatic solid lesions (pdac and neuroendocrine tumours).

a probe specifically designed for endoscopic ultrasound (eus) in vivo treatment of human pancreatic solid masses will be used. the probe is connected to a radiofrequency generator on which the power can be set and the tip of the probe (on the tip is present the radiofrequency electrode) is continuously perfused by chilled solution. the generator can stop the power supply when the tissue impedance goes beyond the threshold value to prevent tissue carbonization

Eligibility criteria:
inclusion criteria: pancreatic solid lesion presence (pancreatic adenocarcinoma and neuroendocrine tumors) resected during pancreatic surgery - exclusion criteria: no signature on informed consent -
facilitating endotracheal intubation by laryngoscopy technique and apneic oxygenation within the intensive care unit: the fellow study

Conditions: Respiratory Failure

Summary: respiratory failure requiring endotracheal intubation occurs in as many as 40% of critically ill patients. procedural complications including failed attempts at intubation, esophageal intubation, arterial oxygen desaturation, aspiration, hypotension, cardiac arrest, and death are common in this setting. while there are many important components of successful airway management in critical illness, the maintenance of adequate arterial hemoglobin saturation from procedure initiation until endotracheal tube placement is paramount as desaturation is the most common factor associated with peri-intubation cardiac arrest and death. interventions that either shorten the duration of time required for tube placement or prolong the period before desaturation may be effective in improving outcome. the high rate of complications and the lack of existing evidence regarding the efficacy of current airway management techniques in shortening the time to airway establishment or prolonging the time to desaturation mandates further investigation. the primary hypothesis is that video laryngoscopy will be superior to direct laryngoscopy in successful first attempt at endotracheal intubation (defined by confirmed placement of an endotracheal tube in the trachea during first laryngoscopy attempt) of medical icu patients by pulmonary/critical care medicine fellows after controlling for the operator's past number of procedures with the equipment used. also, the investigators hypothesize that the provision of apneic oxygenation during the endotracheal intubation procedure (defined as a nasal cannula with 15 liters per minute of oxygen flow placed prior to sedation or neuromuscular blockade and maintained until after completion of the procedure) will result in a higher arterial oxygen saturation nadir (defined as lowest noninvasive oxygenation saturation value observed between the administration of sedation and/or neuromuscular blockade and 2 minutes after successfully secured airway or death) compared to no apneic oxygenation.


Eligibility criteria:
inclusion criteria: * adults * medical icu patients * require endotracheal intubation * endotracheal intubation to be performed by pulmonary/critical care medicine fellow * sedation and/or neuromuscular blockade is planned for the procedure exclusion criteria: * operators other than pulmonary/critical care medicine fellows * the operator predetermines that the patient requires specific intubating equipment or oxygenation technique will be required for the safe performance of the procedure

Keywords: endotracheal intubation apneic oxygenation respiratory failure
japanese study of ipilimumab administered in combination with paclitaxel/carboplatin in patients with nonsmall-cell lung cancer

Conditions: Non-Small Cell Lung Cancer

Summary: the primary purpose of this study was to establish the recommended dose of ipilimumab administered in combination with paclitaxel and carboplatin in japanese patients with nonsmall-cell lung cancer.


Eligibility criteria:
key inclusion criteria: * histologically or cytologically documented nonsmall-cell lung cancer (nsclc) presenting as stage iiib disease without indications for definitive radiotherapy, stage iv disease, or recurrent disease following radiation therapy or surgical resection * no prior chemotherapy, hormonal therapy, immunotherapy, or targeted-therapy-containing regimens for the treatment of nsclc * life expectancy of at least 3 months * eastern cooperative oncology group performance score of 0-1 * adequate bone marrow function * hemoglobin ≥9.0 g/dl * absolute neutrophil count ≥1,500/mm\^3 * platelet count ≥100,000/mm\^3 * adequate liver function * total bilirubin level ≤2.0\*the upper limit of normal (uln) * asparate aminotransferase level ≤2.5\*uln * alanine aminotransferase level ≤2.5\*uln * adequate renal function * calculated creatinine clearance based on cockcroft and gault formula ≥50 ml/min. key exclusion criteria: * symptomatic central nervous system (cns) metastasis or active cns metastasis requiring medication * malignant body cavity fluid (eg, pleural effusion, cardiac effusion, ascites) that recurred despite appropriate supportive care * prior radiation of ≥30% of major bone-marrow containing areas (pelvis, lumbar spine) * documented history of severe autoimmune or immune-mediated symptomatic disease that required prolonged (longer than 2 months) systemic immunosuppressant treatment * documented history of motor neuropathy considered of autoimmune origin (eg, guillain barré syndrome) * any concurrent malignancy other than nonmelanoma skin cancer, carcinoma in situ of the cervix, carcinoma in situ of the breast, carcinoma of the mucous membrane of the gastrointestinal tract, or superficial bladder cancer treated with systemic therapy * ≥grade 2 diarrhea * history of or concurrent disease of gastrointestinal tract perforations * ≥grade 2 peripheral neuropathy (motor or sensory) * uncontrolled intercurrent illness including infection requiring systemic therapy, symptomatic congestive heart failure, uncontrolled hypertension, uncontrolled angina pectoris, uncontrolled peptic ulcer, and cardiac arrhythmia requiring medication * positive finding for human immunodeficiency virus antibody, hepatitis b surface antigen, or hepatitis c virus antibody.
evaluation of marginal bone loss after immediate implant placement in esthetic zone without xenograft.

Conditions: Bone Loss

Summary: marginal bone loss in immediate implant placement in upper esthetic zone by comparing between non grafting in immediate implant placement with xenograft placement in other side. the study is to assess the marginal bone loss in the two techniques and compare results between them.

marginal bone loss in immediate implant placement in upper esthetic zone by comparing between non grafting in immediate implant placement with xenograft placement in other side. the study is to assess the marginal bone loss in the two techniques and compare results between them after follow up period of 4 months.

Eligibility criteria:
inclusion criteria: * adult patients with badly broken teeth in upper esthetic zone indicated for extraction presence of at least 4 mm of bone beyond root apex exclusion criteria: * presence of fenestrations or dehiscences of the residual bony walls after extraction heavy smokers more than 20 cigarettes per day. systemic diseases that may affect normal healing. psychiatric problems.

Keywords: immediate implant upper esthetic zone marginal bone loss
observational study of best supportive care with or without surgery, chemo or radiotherapy in pts with carcinoma of lung

Conditions: Lung Cancer

Summary: the purpose of this study is to establish a listing (database) of patients diagnosed with lung cancer and treated with best supportive care and standard and investigational chemotherapy regimens, surgery, and radiation therapy at the unm crtc and other nmcca sites. the information will be used to determine the results of various treatments for lung cancer subjects and to find where improvements can be made in safety, effectiveness, supportive care, treatment that eases tumors without curing them, treatments that cure tumors, prevention, and follow-up efforts. the database information will be compared to clinical trial data published in peer-reviewed journals and seer outcome data. patients will be acquired both before and after they are treated for lung cancer.

same as above.

Eligibility criteria:
inclusion criteria: * those who are eligible for this treatment protocol will consist of: 1. patients with histologically diagnosed lung cancer. 2. patients receiving therapy should have an ecog/zubrod/swog performance status of \<3 at the time of the initiation of therapy. 3. all newly diagnosed patients referred to an nmcc alliance site will be eligible, as will patients with recurrent disease that are now referred to an nmcca for their next therapy (such as those who move from out of state, or are referred for protocol therapy), though efforts will be made to obtain records of prior therapy administered elsewhere). exclusion criteria: * patients not falling under any of the above criteria are not eligible for the study. * withdrawal of the informed consent at any point in the study excludes patient from the study.

Keywords: best supportive care protocol of standard practice carcinoma of the lung
effect of lidocaine block in traumatic brain injury

Conditions: Traumatic Brain Injury

Summary: the goal of this or clinical trial is to explore efficacy of stellate ganglion block on dysphagia and activities of daily living in traumatic brain injury patients. the main question it aims to answer are: can stellate ganglion block improve the dysphagia and activities of daily living in traumatic brain injury patients. traumatic brain injury patients will be divided into the the control group and observation group evenly. all the patients were provided with routine therapy, while the patients in the observation group were given stellate ganglion block. the swallowing function, and activities of daily living of the two groups of patients before and after treatment were evaluated.

dysphagia, or swallowing difficulty, is a common symptom in traumatic brain injury patients. the goal of this or clinical trial is to explore efficacy of stellate ganglion block on dysphagia and activities of daily living in traumatic brain injury patients. the main question it aims to answer are: can stellate ganglion block improve the dysphagia and activities of daily living in traumatic brain injury patients. traumatic brain injury patients will be divided into the the control group and observation group evenly. all the patients were provided with routine therapy, while the patients in the observation group were given stellate ganglion block. the swallowing function, and activities of daily living of the two groups of patients before and after treatment were evaluated.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years, meeting the diagnosis of traumatic brain injury; * presence of no contraindication for stellate ganglion block; * with stable vital signs and no severe liver or kidney dysfunction, metabolic disorders. * informed consent form was obtained from the patient's family members, indicating their full - understanding of the study and agreement to participate. exclusion criteria: * unable to cooperate in completing treatment and assessment due to personal reasons or other disorders; * complicated with other intracranial lesions, such as stroke; * with severe consciousness disorders caused by other diseases.
effectiveness of an intervention combining adapted physical activity and therapeutic education in patients with chronic symptoms attributed to lyme borreliosis.

Conditions: Lyme Borreliosis; Physical Activity; Lyme Borreliosis, Nervous System

Summary: lyme borreliosis, commonly known as lyme disease, has been clinically described for more than a century, but has been officially recognized for 40 years, with the detection of the borrelia bacterium by w. burgdorfer, in ticks of the ixodes ricinus complex, identified a few years before.

apart from the early localized presentation, with a well established treatment, lyme borreliosis is a complex infection. indeed, its presentation can be late and very polymorphic, which can evoke functional somatic disorders and make its management difficult. in 2016, the french ministry of health decided to launch a national plan to fight lyme borreliosis. one of the objectives of this national plan was to improve management based on a specific multidisciplinary care pathway.

Eligibility criteria:
inclusion criteria: * patient referred to the reference center for tick-borne diseases by his attending physician * duration of symptoms \>6 months * at the end of the initial assessment, the diagnosis of functional somatic disorders is retained after consensus between the physicians * patient practicing less than 150 minutes of regular physical activity per week (who recommendations) exclusion criteria: * patients with cardiac or respiratory pathologies that contraindicate the practice of physical activity physical activity * important comorbidities contraindicating the practice of physical activity: associated cardiac pathologies associated cardiac pathologies (severe rhythm disorders such as rapid atrial fibrillation), respiratory pathologies respiratory pathologies (obstructive or severe restrictive respiratory insufficiency), disabling joint pathologies joint pathologies (gonarthrosis or coxarthrosis limiting training on a treadmill or on a high-intensity bicycle). intensity cycling). * patients under guardianship or curatorship

Keywords: sedentary time therapeutic education of the patient adapted physical activity training program
effects of hamstring stretching using pressure biofeedback unit in patients with low back pain.

Conditions: Low Back Pain

Summary: to determine the effects of hamstring stretching using a pressure biofeedback unit on muscle length, pain, and functional status in patients with low back pain.

several studies have been conducted regarding hamstring stretching with the pelvis anteriorly tilted for treating low back pain but there is very little evidence regarding the use of a pressure biofeedback unit for maintaining anterior pelvic tilt so this study aims to find out whether the hamstring stretching while maintaining anterior pelvic tilt using pressure biofeedback is more effective than hamstring stretching without using pressure biofeedback in patients with low back pain.

Eligibility criteria:
inclusion criteria: * patients with non-specific low back pain * chronic pain \> 3 months * participants having (odi) score minimum 20% to 40% * participants with hamstrings shorter than 70 degrees bilaterally * participants who scored 3 or more than 3 on the numeric pain rating scale (nprs) exclusion criteria: * history of fracture and surgery * patients with osteoarthritis and spondylolisthesis * patients with systemic disease except for diabetes mellitus and hypertension * patients with disc herniation and leg length discrepancy * pregnant females * participants with severe back pain or excessive lumber lordosis

Keywords: hamstring length low back pain pressure biofeedback unit
prognosis of extremely premature birth

Conditions: Infant, Premature, Diseases; Perinatal Morbidity; Development; Problem;Growth

Summary: pregnant women at risk of giving birth before 28 weeks' gestational age will be enrolled. fetal circulation will be studied and blood for inflammatory parameters will be collected. if birth occurs before 28 weeks, detailed information on clinical course of the newborn until discharge from the neonatal intensive care unit will be recorded,and specimens of amniotic fluid, placenta, blood and urine will be collection for inflammatory parameters. after discharge the children will be followed according to a specific protocol until 5 years of age.

the study includes a regional cohort (western norway) of approximately 50 extremely preterm infants born per year over a three year period. detailed information on fetal condition (growth, circulation, infection), neonatal resuscitation and clinical course (details on ventilatory support, circulation, pulmonary function as assessed with a neonatal spirometry technique, cerebral imaging, nutrition, growth) will be recorded. biobank samples of blood and amniotic fluid from the mother, and from placenta, blood, urine, and tracheal aspirates will be collected form the infant, primarily to examine for inflammatory parameters. after discharge, follow-up at 6, 12, 36 and 56 months will be conducted using standardized tests (ages \& stages, infanib, denver developmental screening test, bayley scales, wppsi and abc movement tests).

Eligibility criteria:
inclusion criteria: * born with gestational age less than 28 weeks exclusion criteria: * none

Keywords: extremely premature infant outcome follow-up
retrospective study in patients receiving two or more ozurdex® injections for retinal vein occlusion (rvo)

Conditions: Retinal Vein Occlusion; Macular Edema

Summary: this is a retrospective data collection study to evaluate the efficacy, safety, and re-injection interval of ozurdex® in the treatment of macular edema due to rvo. following informed consent, there were no patient study visits. all data was collected via chart review.


Eligibility criteria:
inclusion criteria: * macular edema * received at least 2 ozurdex® injections exclusion criteria: * received ozurdex® injections as part of a clinical study