Kornimate/medical-research-clean huggingface dataset:
personalized motor learning in primary care physiotherapy (treat)

Conditions: Geriatric Patients; Neurological Disorder

Summary: over the last decade many scientific articles have been published on motor learning in neurological and geriatric rehabilitation. to make the available findings comprehendible and clear for physiotherapists, a card set and website have been developed. the aim of this prospective study is to evaluate the use and experiences of the card set and website designed to aid the physiotherapist in decision making with regards to motor learning. the following research question is central to this evaluation: how are the developed card set and website used and experienced by physiotherapists in primary care during the treatment of patients with neurological or geriatric conditions?

method: formative process evaluation. over the last decade many scientific articles have been published on motor learning in neurological and geriatric rehabilitation. to make the available findings comprehendible and clear for physiotherapists, a card set and website have been developed. participating physiotherapists will use the "card set and website" in their daily practice for a period of six months. to assess the usage and experiences of therapists, digital questionnaires will be administered prior to the intervention, at 3 months, and at 6 months, along with bi-weekly monitoring. the quantitative data from the questionnaires and monitoring will be analyzed using descriptive statistics (e.g., frequency tables, means, medians, iqr, and summary figures). additionally, an interim evaluation will take place where solutions for the main user issues will be collectively brainstormed with the participants. finally, a consensus meeting will be held to reach the final versions of the card set and website. the nominal group technique will be used to ensure active participation from all participants and to achieve consensus on the definitive list of modifications.

Eligibility criteria:
physiotherapists will be eligible for inclusion when they: * have at least one year of working experience * are treating neurological and/or geriatric patients * are able to attend the preparatory training provided by the researchers
multimodal prehabilitation in thoracic surgery

Conditions: Lung Cancer

Summary: this trial aims to assess the impact of a multimodal prehabilitation program in high-risk patients undergoing lung resection surgery.

this trial aims to assess the cost-effectiveness of a multimodal prehabilitation program in high-risk patients undergoing lung resection surgery. secondary objectives are to evaluate the impact of the intervention on: i) healthcare resuorces use; ii) clinical outcomes; and, iii) patient's and professionals experience with the program. the program includes x main interventions: i) a motivational interview; ii) a high-intensity exercise training program; iii) a plan for physical activity incentivation; iv) a nutritional optimization program; v) a psicologichal support program; and, vi) a smoking cessation program.

Eligibility criteria:
inclusion criteria: 1. forced espiratory volume in the first second (fev1) and/or estimated postoperative lung diffusion capacity for carbon monoxide \< 60%; and/or, 2. american society of anesthesiologist (asa) index 3-4; and/or, 3. peak oxygen uptake among 10-20 ml/kg/min. exclusion criteria: 1. non-elective surgery; 2. metastasic disease; 3. unestable cardiac or respiratory condition; 4) cognitive or locomotor limitations precluding the adherence to the program.

Keywords: prehabilitation exercise training physical activity nutrition cognitive behavioural therapy smoking cessation
effect of perineal cryotherapy on episiotomy

Conditions: Normal Vaginal Delivery; Perineal Episiotomy

Summary: the present study aims to evaluate the effect of perineal cryotherapy on episiotomy- associated pain among postpartum women. the study hypothesis: post-partum women who apply perineal cryotherapy have lower level of episiotomy- associated pain than those who don't apply.

the present study included postpartum mothers who are in a good health immediately after giving delivery, having an episiotomy and a normal vaginal birth of a single, full term, healthy baby with normal weight and vertex presentation.

Eligibility criteria:
inclusion criteria: * postpartum mothers who are in a good health immediately after giving delivery. * having an episiotomy and a normal vaginal birth. * having a vaginal birth at full term. * the delivery of a healthy single fetus having normal weight and vertex presentation. exclusion criteria: * women who are experiencing labor or complications after giving birth, such as hemorrhage, a tear, or a cut in the perineum.

Keywords: episiotomy pain perineal cryotherapy
an observational study evaluating efficacy, safety and convenience of novonorm® in treatment of type 2 diabetes in routine clinical practice

Conditions: Diabetes; Diabetes Mellitus, Type 2

Summary: this study is conducted in africa and asia. the aim of this study is to evaluate the efficacy, safety and convenience of using repaglinide (novonorm®) in type 2 diabetes management in routine clinical practice.


Eligibility criteria:
inclusion criteria: * type 2 diabetes * newly diagnosed or not adequately controlled with current therapy
saliva pcr in pregnant women with covid-19

Conditions: Coronavirus Disease 2019 (COVID-19) Pneumonia

Summary: abstract: objectives we aim to study the relative viral load using saliva polymerase chain reaction among pregnant women treated with paxlovid. methods pregnant women with coronavirus disease 2019 were allocated to two groups: those receiving paxlovid and those receiving no antiviral agents. we compared the nasopharyngeal and salivary relative viral loads and their changes in saliva specimens. results among the 38 pregnant women, seventeen received paxlovid, and 21 received no antiviral agents. the viral cycle threshold value of saliva was significantly higher than that from nasopharynx, with a median ± interquartile range of 26.44 ± 7.68 versus 17.6 ± 9.6 in the paxlovid group (p = 0.005). following treatment, the paxlovid group showed a significant decrease in relative saliva viral load (cycle threshold value on day 4/day 5 minus day 0) compared to the non-antiviral group (13.40 ± 5.64 versus -1.59 ± 9.63, p = 0.021). the detection rate of coronavirus disease 2019 using salivary polymerase chain reaction was 81.6% (31/38). conclusions this study showed that saliva is a useful diagnostic tool for coronavirus disease 2019 in pregnant women, and a significant decrease in the relative viral load of saliva was observed in those treated with paxlovid.


Eligibility criteria:
inclusion criteria: * this study enrolled pregnant women admitted to nckuh 70 who tested positive for covid-19 by real-time reverse transcription polymerase chain reaction (rt-pcr) of nasopharyngeal swab specimens. after providing the potential benefits and associated risks of antiviral treatment with paxlovid, patients made a well-informed decision about whether or not to receive paxlovid (300/100 mg nirmatrelvir/ritonavir, pfizer inc., usa) twice daily for 5 days. exclusion criteria: * pregnant women were excluded if the time interval between the onset of symptoms and admission to our hospital was greater than seven days, in the case of insufficient saliva samples, or if any antiviral-related agents were administered, such as remdesivir, glucocorticoids, or interleukin-6 receptor antagonists.

Keywords: severe acute respiratory syndrome coronavirus 2; pregnancy; nirmatrelvir/ritonavir 25 (paxlovid); saliva
safety and efficacy trial of imexon plus dtic in advanced malignant melanoma

Conditions: Malignant Melanoma

Summary: amp-005 is a phase 1b/2 clinical trial designed to evaluate whether the new drug, imexon, can be administered in combination with the approved drug, dacarbazine (dtic), for the treatment of patients with stage iii or iv inoperable melanoma. the phase 1b part of the study is designed to determine whether the two drugs can be safely combined together, and the phase 2 part of the study is designed to provide additional safety data and to gain an understanding of whether adding imexon to dtic can improve the outcome for melanoma patients versus the findings from prior clinical studies of dtic alone.


Eligibility criteria:
inclusion criteria: * malignant melanoma; inoperable stage iii or iv disease. * able to perform the activities of daily living. * a projected life expectancy of at least 4 months. * if female, neither pregnant nor nursing. * willing to use contraceptives to prevent pregnancy. * blood cell counts and blood chemistries in or near normal range. * prior radiation is permitted. * no other serious illnesses. * no other active malignancy. * no serious infections. * no other current drug therapy for the cancer or steroid therapy. exclusion criteria: * no prior chemotherapy for the stage iii or iv disease. * brain metastases
definitive ccrt combined with durvalumab and tremelimumab for inoperable esophageal cancer

Conditions: Esophageal Squamous Cell Carcinoma

Summary: this is a single arm phase ii study, in which 2 cycles of chemotherapy (5fu/cddp) and immunotherapy (durvalumab and tremelimumab) are administered every 3 weeks with concurrent radiotherapy for inoperable locally advanced esophageal squamous cell carcinoma. four weeks after completion of ccrt combined with immunotherapy, 2 cycles of durvaluma and tremelimumab will be administered every 4 weeks and thereafter durvalumab monotherapy q4w will be maintained until unacceptable toxicity or disease progression, or for maximum 2 years after enrollment.


Eligibility criteria:
inclusion criteria: * histologically confirmed squamous esophageal cancer * the clinical stage t2-3n0m0 or t1-3n1-3m0 * inoperable case: it refers to medically inoperable status and/or patient's refusal to surgery and/or cervical location and/or locoregionally recurrent tumor after primary surgery * ecog ps of 0 to 1 exclusion criteria: * clinical t4 disease (for example, invasion to aorta, vertebral body, or trachea/bronchus) or distant metastasis (m1) * previously received radiotherapy for esophageal cancer
quarantine and telerehabilitation in chronic pain patients during covid-19 pandemic.

Conditions: Chronic Pain

Summary: the quarantine during covid-19 pandemic has changed daily routine. staying at home for prolonged periods of time can pose a significant challenge for patients with chronic pain. the purpose of the current study is to investigate how the quarantine effects of psychosocial factors, quality of life, sleep, nutrition and physical activity in patients with chronic musculoskeletal pain. another purpose is to examine whether a telerehabilitation exercise program is effective during the lockdown period.

participants, both male and female, with chronic musculoskeletal pain for at least 3 months will be included in the study. they will complete some questions about anxiety, depression, sleep, nutrition, quality of life, pain behavior and characteristics, illness perceptions, functioning and daily routine. questionnaires will be completed twice (first and last week of quarantine, 40 days of duration). a group of patients will follow an exercise program during this time. it will be evaluated the link between the question of physical and psychological factors in the experience of pain in quarantine situation and, also, it will examine whether a telerehabilitation exercise program is effective during the lockdown period.

Eligibility criteria:
inclusion criteria: * patient with chronic musculoskeletal pain (chronic pain will be defined as pain lasting for 3 or more months. also, pain intensity will be at least 3 on a 0-10 numerical pain rating scale on most days of the last 3 months). * patient with sufficient understanding of the greek language exclusion criteria: * patients without being at quarantine * systemic diseases such as rheumatoid arthritis, fibromyalgia and/or polymyalgia rheumatic * osteoporosis, haemophilia and/or cancer * recent surgery or trauma * being pregnant or given birth in the preceding year * cognitive impairment * inability to provide informed consent and/or complete written questionnaires

Keywords: covid-19 quarantine musculoskeletal telerehabilitation psychosocial sleep exercise
a digital resilience intervention for emergency medical service workers

Conditions: Feasibility; Acceptability; Adoptability; Meaning Made; Adaptive Self-reflection; Recovery Activities; Recovery Experiences; Post Traumatic Stress Disorder PTSD; Anxiety; Depression

Summary: emergency medical service (ems) workers (i.e., ambulance service providers) experience triple the risk for anxiety, depression, and posttraumatic stress disorder (ptsd) compared to the general u.s. population. these mental disorders impact health and well-being across the life course. thus, there is a critical need for interventions targeting key risk factors that can reduce ems workers' mental health risk. chronic stress represents such a risk factor and is a routine feature of the ems profession due to the demands of providing emergency medical care. self-reflective resilience-recovery activity promotion training (srr-rapt) promotes finding positive meaning in stressors by building self-awareness of the coping and regulatory responses used to manage them; evaluating those responses; adapting them based upon their perceived effectiveness; and developing a plan for managing similar stressors in the future based on what can be learned from the current situation. in addition to prompting self-monitoring and active reflection on stressors and coping responses, srr-rapt encourages practicing recovery activities that permit a person's stressor induced strain level to return to baseline. the primary objective of the current study is to evaluate the feasibility, acceptability, and adoptability of srr-rapt among ems personnel. a secondary objective was to examine the intervention's effect on hypothesized mechanisms of action predicted to vary in response to the intervention, as well as consider the intervention's ability to reduce mental health symptoms. it is hypothesized that the intervention will be associated with more positive meaning made, adaptive self-reflection, recovery activities, and recovery experiences, as well as lower levels of mental health symptoms.


Eligibility criteria:
inclusion criteria: * full-time or part-time employee at an emergency medical service agency * ≥ 18 years of age * ≥ 1 emergency medical service shift scheduled in the next 8 days from recruitment date. exclusion criteria: * not a full-time or part-time employee at an emergency medical service agency * \< 18 years of age * \< 1 emergency medical service shift scheduled in the next 8 days from recruitment date.

Keywords: emergency medical service personnel psychological resilience
comparison of aerobic training and circuit training in healthy children

Conditions: Healthy Population

Summary: childhood obesity is a growing concern, with potential consequences for long-term health. the number of obese children has increased more than tenfold in the last forty years. over the course of their lifetimes, more and more young people worldwide will be exposed to obesity, which will hasten the onset of type 2 diabetes, fatty liver, and cardiovascular problems. promoting physical activity in children is crucial for maintaining a healthy weight and improving overall well-being. less than 30% of kids and teenagers worldwide fulfill the recommended daily minimum of 60 minutes of moderate to intense physical activity. since that most children and adolescents spend a significant amount of time traveling to and from school or attending school, schools may be the best places for interventions. this project will investigate the effectiveness of two common exercise approaches, aerobic training and circuit training, on body mass index (bmi), physical fitness, and quality of life in healthy children. a randomized controlled trial will be conducted, recruiting healthy children within a specific age range 8-12. this study will be conducted in the leader's lyceum school.two experimental groups will be made. participants will be randomly assigned to either an aerobic training group or a circuit training group. non-probability convenient sampling technique will be used. the study will include the children from age 8 to 12, both genders, healthy children. both programs will be implemented for a set duration of 12 weeks, with specific parameters regarding intensity, duration, and exercise types. the project will assess changes in bmi, physical fitness components (e.g., cardiovascular endurance, muscular strength, flexibility), and quality of life through validated measures, including pediatric quality of life generic score 4.0 (pedsql), physical fitness test, presidential fitness test and bmi.


Eligibility criteria:
inclusion criteria: * ⦁ school age children from age 7-12 years * both genders, male and female * healthy and fit children * interventions should be given inside the premises of school * children with normal range bmi: 13.3-24.1 * children with presidential fitness score at or above the 85th percentile * children with quality of life score: minimum 50 exclusion criteria: * ⦁ any children havig any mental condition: depession or anxiety * visual, vestibular, or balance disorders in the preceding six months * children with any orthotic devices * children undertaking any previous aerobic or circuit training * refusal of any child or parent to participate

Keywords: obesity physical activity aerobic training circuit training body mass index quality of life
a study comparing the effects and safety of dulaglutide with glimepiride in type 2 diabetes mellitus

Conditions: Type 2 Diabetes Mellitus

Summary: the purpose of this study is to examine if once-weekly dulaglutide is efficient and safe compared to glimepiride in participants with type 2 diabetes mellitus who have inadequate glycemic control with oral antihyperglycemic medication (oam) or are oam-naïve.


Eligibility criteria:
inclusion criteria: * type 2 diabetes mellitus * oam-naïve or have been taking oam monotherapy for at least 3 months * glycosylated hemoglobin (hba1c) value of ≥7.0% to ≤10.5% for oam-naïve participants or ≥6.5% to ≤10.0% for participants taking oam monotherapy * adult men or adult non-pregnant, non-breastfeeding women * stable weight (±5%) ≥3 months prior to screening * body mass index (bmi) of ≥19.0 to ≤35.0 kilograms per square meter (kg/m\^2) exclusion criteria: * have type 1 diabetes mellitus * have previously been treated with a glucagon-like peptide-1 (glp-1) receptor agonist, glp-1 analog, or any other incretin mimetic during the 3 months before screening * are currently taking dipeptidylpeptidase-iv (dpp-iv) inhibitor and thiazolidinediones (tzd) during the 3 months before screening * have gastric emptying abnormality * have cardiac disorder defined as unstable angina, myocardial infarction, coronary artery bypass graft surgery, percutaneous coronary intervention, heart failure, arrhythmia, transient ischemic attack, or stroke * have poorly controlled hypertension (systolic blood pressure above 160 millimeters of mercury \[mmhg\] or diastolic blood pressure above 95 mmhg) * have impaired liver function * have impaired kidney function * have history of chronic pancreatitis or acute pancreatitis * have a serum calcitonin ≥20 picogram/milliliter (pg/ml) * have a personal or family history of medullary c-cell hyperplasia, focal hyperplasia, carcinoma or multiple endocrine neoplasia type 2 (men 2)
manuka honey as an adjunct to non-surgical periodontal therapy: clinical study

Conditions: Periodontal Diseases; Periodontal Pocket; Periodontal Bone Loss; Periodontal Attachment Loss

Summary: the goal of this split-mouth clinical trial is to evaluate the effects of manuka honey applied into periodontal pockets after initial periodontal therapy (nspt) in the treatment of stage 3 periodontitis. the main question it aims to answer is: • does the adjunct of manuka honey improve the outcome of the non-surgical periodontal treatment. the intervention in this study was conducted in a split-mouth design, meaning that after completing the nspt for each subject, manuka honey was administered as an adjunct to the periodontal treatment in two randomly selected quadrants of the oral cavity around the teeth with a specially designed cannula. this was followed by oral hygiene instructions and training. the home-performed oral hygiene procedures were focused on interdental cleaning using dental floss and toothbrushing with regular fluoride-containing toothpaste. the subjects were also instructed not to use any form of oral antiseptic (e.g., chlorhexidine) or antibiotic during the follow-up period.


Eligibility criteria:
inclusion criteria: * patients of both genders with good systemic health; * non-smokers; * presence of at least 20 teeth; * untreated moderate to advanced generalized chronic periodontitis according to the 1999 classification 199 , i.e., generalized stage iii periodontitis according to the 2007 classification exclusion criteria: * pregnant and nursing women; * antibiotics prescribed for dental or non-dental diseases 6 months before the start of the research; * systemic diseases or the use of drugs known to affect periodontal tissues, bleeding parameters; * acute oral or periodontal inflammation or infection (pericoronitis, necrotizing periodontal diseases, etc.).

Keywords: periodontitis manuka honey periodontal pocket depth
general anesthesia vs paravertebral block with general anesthesia for laparoscopic sleeve gastrectomy

Conditions: Pain, Postoperative

Summary: the incidence of obesity is steadily rising. laparoscopic sleeve gastrectomy (lsg) is an innovative approach to the surgical management of morbid obesity. we will be discussing the effect of adding paravertebral block (pvb) in addition to general anesthesia (ga) vs. ga alone for post operative pain after laparoscopic sleeve gastrectomy.

this is a prospective, randomized, double-blind controlled clinical trial. written informed consent will be obtained from patients. patients will be randomly assigned using the sealed envelope technique into 2 equal groups: group 1 will be patients who receive general anesthesia with paravertebral block, whereas group 2 will be patients who receive general anesthesia with placebo block.

Eligibility criteria:
inclusion criteria: * patients with body mass index (bmi) greater than or equal to 30 * american society of anesthesiologist (asa) score greater than or equal to 2 * undergoing laparoscopic gastric sleeve surgeries exclusion criteria: * patients with asa score less than 2 and greater than 4 * patients with any type of allergy to local anesthesia * patients refusing to be part of the study (refusal to sign consent) * any complication during surgery or anesthesia