Kornimate/medical-research-clean huggingface dataset:
a web-based platform to improve physical function, nutrition, and mindfulness in patients with long covid

Conditions: Long COVID

Summary: patients with covid-19 may experience prolonged physical and psychological symptoms after weeks or months of the infection. this may be caused by a combination of factors including poor nutrition, low physical activity, and lack of emotional support. leading to poor overall health and low quality of life. this evidence indicated that people with long covid-19 need a personalized intervention. our objective is to determine if the use of an online application that is based on preventive self-care and that includes nutrition and mindfulness will be feasible to use for patients with long covid.

a canadian web-based platform called my viva plan® became available. this web-based platform is based on preventive self-care and it includes three key pillars of health: nutrition and mindfulness. long covid patients will be randomized into the following two groups; intervention arm (will use a web-based platform for 8 weeks) vs. control arm (will not use a web-based platform for 8 weeks).the primary aim of this study is to investigate the feasibility (defined by recruitment, adherence, and retention) of an 8-week digital nutrition and mindfulness self-care intervention program using my viva plan® versus usual care (i.e. general advice) in patients with long covid who continue to have signs and symptoms not explainable by other causes. dietary intake, physical function, body composition and mental health variables will also be explored.

Eligibility criteria:
inclusion criteria: * aged ≥ 18 years. * covid diagnosed (pcr positivity) \>12 weeks at time of screening and have persistent symptoms. * body mass index (bmi) \>18.5kg/m2 and \< 35 kg/m2. * people with long covid syndrome diagnosis enrolled in the kaye edmonton clinic. * have mild to moderate long covid syndrome (based on the post covid-19 functional status scale from 0-3). exclusion criteria: * patients with severe mobility impairment (people without sufficiently mobile to come to the study centre). * diagnosis of severe mental health disorders (e.g., depression, anxiety, eating disorders). * individuals with pacemakers or other internal electrical medical devices. * suffer from claustrophobia. * pregnancy or lactation. * no internet access. * not able to understand and communicate in english. * major visual or hearing impairment or other serious illness that would preclude participation. * living in assisted living situations or a nursing home. * individuals who fell more than 3 times in the last month. because of the risk of doing a physical activity unsupervised. * not willing to make a change in their lifestyle (readiness to change).

Keywords: nutrition physical activity feasibility body composition
insulin resistance, polycystic ovary syndrome, and bone research study

Conditions: Polycystic Ovary Syndrome

Summary: the purpose is to investigate the effects of 2 different treatments (drospirenone/ethinyl estradiol versus rosiglitazone) on insulin sensitivity and androgen levels, inflammatory markers, vascular markers and bone development in overweight adolescent females with polycystic ovary syndrome (pcos).

the purpose of this study is to: 1) to compare effects of treatment with drospirenone/ethinyl estradiol (yasmin)versus rosiglitazone (avandia) on hyperandrogenism, insulin resistance/hyperinsulinemia, adrenal hyperresponsiveness, body composition, chronic inflammation, bone mass and turnover. ocps are the first-line therapy for pcos, however, they do not address the insulin resistance or the inflammation. insulin sensitizers have been used successfully to treat pcos but thiazolidinediones such as rosiglitazone have not been used in adolescents. therefore we will investigate the effects of treatment with drospirenone/ethinyl estradiol versus rosiglitazone in overweight adolescents with pcos. we will obtain comprehensive evaluations before and 6 months after randomization, to the respective treatment arms to determine the differences between the 2 treatment modalities.

Eligibility criteria:
inclusion criteria: * age 10 - 20 years * pubertal level of tanner stage iii-v and menarchal * bmi percentile for age and sex greater than or equal to 85%ile exclusion criteria: * oral medications for pcos, or that have impact on bone (i.e. anti-epileptics) * presence of other diseases, systemic or psychiatric, or chronic medications which could interfere with endocrine function * established diagnosis of diabetes * prior bone surgery, prior osteoporotic fracture, or fracture in the past 12 months * prior thromboembolic event, such as a deep venous thrombosis or pulmonary embolism (pcos subjects only) * vitamin d deficiency (\<10ng/ml) * hyperkalemia (k\>5.0 meq/l) * positive pregnancy test (serum)
fes assisted cycling in children with cp

Conditions: Cerebral Palsy Spastic Diplegia

Summary: this project proposes to assess if functional electrical stimulation (fes) assisted cycling can improve the cycling ability, muscle strength, cardiovascular health, quality of life, self perception and functional mobility of adolescents with cp better than a volitional cycling program or a non-intervention control group.

aim 1: to compare the effects of 8-weeks of fes-assisted cycling training on improving cardiorespiratory fitness, walking function, self-motivated exercise/recreation, self-perception and functional mobility and quality of life of adolescents with spastic cp with marginal walking ability (gross motor function classification system levels ii - iv) vs. 8-weeks of volitional cycling training and a non-intervention control group. aim 2: to compare the effects of 8-weeks fes-assisted cycling training on changes in cycling ability of adolescents with spastic cp with marginal walking ability vs. 8-weeks of volitional cycling training and a nonintervention control group. aim 3: to elucidate the mechanisms for potential improvements in cycling ability after 8-weeks of fes-assisted or volitional cycling training of adolescents with spastic cp and marginal walking ability.

Eligibility criteria:
inclusion criteria: * spastic cp (di-, tetra-, or triplegic) * level ii, iii or iv gmfcs classification * sufficient covering of the femoral head in the acetabulum (migration % \< 40) * adequate range of motion of the hips, knees and ankles to allow pedaling * visual, perceptual, cognitive, and communication skills to follow multiple step commands for attending to exercise and data collection * seizure-free or well controlled seizures exclusion criteria: * athetoid, ataxic, or hemiplegic cp * significant scoliosis (primary curve \> 40°) * spinal fusions extending into the pelvis * severe tactile hypersensitivity * joint instability or dislocation in le * le surgery or fractures in the past year * botox injections to le in the past 6 months * severe spasticity in le (mod ashworth 4) * le joint pain during cycling * hx of pulmonary disease limiting exercise tolerance or hx of cardiac disease * severely limited rom / contractures that prevent the subject from being able to be safely positioned on the cycle * pregnancy

Keywords: cerebral palsy functional electrical stimulation cycling
early warning model of susceptibility and high-risk population of cervical cancer related to hpv

Conditions: Uterine Cervical Neoplasm; Uterine Cervical Cancer; Cervical Cancer

Summary: most uterine cervical high-risk human papillomavirus (hpv) infections are transient, with only a small fraction developing into cervical cancer. family aggregation studies and heritability estimates suggest a significant inherited genetic component. candidate gene studies and previous genome-wide association studies (gwass) report associations between the hla region and cervical cancer. adopting a genome-wide approach, we aimed to establish an early warning model for a high-risk population of cervical cancer.


Eligibility criteria:
inclusion criteria: * (1) case group a) aged 25-75 years. b) han nationality. c) patients with cervical cancer or cervical precancerous lesions above cin2 diagnosed by biopsy or postoperative pathological diagnosis. * (2) control group: a) aged 25-75 years. b) han nationality. c) no family history of cervical cancer or precancerous lesions. d) the results of tct examination showed no abnormality. exclusion criteria: * (1) suffering from other neoplastic diseases. * (2) pregnant women. * (3) those with a history of bone marrow transplantation.
in vitro fertilization outcomes in metabolic syndrome

Conditions: Metabolic Syndrome

Summary: the purpose of this study is to examine the effect of metabolic syndrome in over-weight women on ivf treatment outcomes.

this porpuse of the study is to examine the physiology of crp during the ivf cycle in and to evaluated the effect of crp in patient with and without metabolic syndrome on ivf outcomes

Eligibility criteria:
inclusion criteria: * women undergoing ivf treatment exclusion criteria: * inflammatory disease * acute conditions

Keywords: metabolic syndrome in vitro fertilization c reactive protein over-weight women ovarian stimulation
transfusions and nitric oxide level in preterm infants

Conditions: Prematurity; Anemia; Necrotizing Enterocolitis

Summary: the purpose of this study is to better understand s-nitrosohemeglobin (sno-hb) in transfused blood of extremely preterm infants. the long term goal of the project is to identify variation in the sno-hb between packed red blood cell units, and between and among individual preterm infants pre and post-transfusion. duke investigators are developing methods to replenish sno-hb, which, if successful, would improve rbc deformation in addition to providing a vasodilatory stimulation to hypoxic tissue, and lead to a randomized clinical trial testing treated vs. untreated rbc transfusions in extremely premature infants. aim 1. measure the total hemoglobin (hb)-bound nitric oxide (no), hb \[fe\] no, sno-hb (a calculated value = (total hb-no - hb \[fe\] no) in blood to be transfused in extremely preterm babies, and in samples pre and post- transfusion from the babies. hypothesis 1: measures of no and sno-hb will be low in blood used for transfusion in preterm infants and will be decreased in the post-transfusion samples from the infants compared with the pre-transfusion samples. aim 2. collect clinical data about study participants, including oxygen saturation and measures of perfusion pre and post-transfusion. hypothesis 2: measures of perfusion will be reduced by 20% post-transfusion in extremely preterm infants.


Eligibility criteria:
inclusion criteria: * infant \< 28 weeks gestation at birth * undergoing prbc transfusion with a volume ≥ 10 cc/kg * availability and willingness of the parent/legally authorized representative to provide written informed consent. exclusion criteria: * any concomitant condition, which in the opinion of the investigator would preclude a patient's participation in the study * previous participation in the study.
vigip-sep2: evaluation of the impact of the training of patients by a nurse on the adverse drug reaction reporting by rrms patient via a mobile application: randomized real-life study

Conditions: Multiple Sclerosis

Summary: the patient's reporting of adverse drug reactions (adrs) is recognized as being of interest for post-marketing safety monitoring, but is still underdeveloped in france, with an average lower than the european average. a multidisciplinary team of the university hospital of caen, composed of neurologists and pharmacovigilants, has been carrying out since autumn 2017 a national study (vigip-sep1) with 24 research centers in france (12 universitary hospitals, 6 general hospitals, and 6 private-practice neurologists) whose main objective was to evaluate the impact of multiple sclerosis (ms) patients' use of a mobile application (app) to report their adrs. my ereport france® has been developed by the evedrug company: adr reports are sent by patients directly to the regional pharmacovigilance centers, after analyze, clinical pharmacologist send it to the national competent authority. as part of vigip-sep1, the accompaniment for the use of the app was carried out very simply by neurologists. we designed a randomized controlled trial based on the assumption that a nurse training of the patient, after the initial prescription of an oral ms drug, with a telephone follow-up within 6 months, will increase by 3 times the number of patients who report adrs compared to a simple information presented by the neurologist. the number of subjects required is 23 subjects per group.


Eligibility criteria:
inclusion criteria: * more than 18 years * multiple sclerosis in initiation with a dmt * patient informed and who gave informed consent exclusion criteria: * patient without mobile or tablet
abdominal ultrasound with doppler and peripheral hemogram in assesment inflammatory bowel disease

Conditions: Inflammatory Bowel Diseases

Summary: assessment of inflammatory bowel disease patients in activity and remission by abdominal ultrasound examine non-invasive and in physiological condition by measuring the colon wall thickness in diagnosis and follow up the patient also including extra intestinal features such as the splanchnic vessels,mesentery and lymph nodes . doppler u.s can evaluate bowel wall vascularity in activity and remission . peripheral hemogram in relationship to activity inflammatory bowel disease asses anemia ,increase monocyte and decrease mean platelet volume( mpv) . also,the investigator will evaluate the outcome of different lines of treatment traditional and biologic therapy (response to treatment,times of activity and complications)

the participants will follow up the patient for 1 year in the first visit all patients in this study will be subjected to: 1. detailed history. 2. careful physical examination 3. laboratory investigation 1. complete blood picture. 2. liver function 3. kidney function 4. iron profile(serum iron ,serum ferritin 5. esr (erythrocyte sedimentation rate ) g-crp (c reactive protein) f-ldh (lactate dehydrogenase) 4. abdominal us(the colon wall thickness,lymph nodes,mass,other organs) 5. doppler us (mesenteric vessels) 6. colonoscopy after 1 year of treatment follow up every 3 months by abdominal us and peripheral hemogram and last visit after 1 year colonoscopy and biopsy for assessment response to treatment

Eligibility criteria:
inclusion criteria * patients diagnosed ulcerative colitis at age(15-60) * patients diagnosed crohns disease at age(15-60)k exclusion criteria * liver cirrhosis and portal hypertension * spontaneous bacterial peritonitis * ischemic colitis
survey of postoperative pain and pain management in norwegian hospitals

Conditions: Pain, Postoperative

Summary: the study is a national survey of pain and pain management to surgical patients in norwegian hospitals. data on pain management are gathered from patient records and data on pain and patient satisfaction are gathered as patients' self report.


Eligibility criteria:
inclusion criteria: * surgery previous day exclusion criteria: * declined participation * unable to communicate (delirious, sedated, intubated) * does not read and speak norwegian * patient not available (for instance having physiotherapy og examinations during data collection)

Keywords: administered analgesic therapy
upper extremity function in cerebral palsy and its association with balance and trunk control

Conditions: Cerebral Palsy

Summary: children with cerebral palsy (cp) have postural control problems due to the lack of motor and sensory development. trunk control which has an important role in ensuring postural control, is the basis for sitting, mobility, development of the upper extremity, pulmonary function and activities of daily living. poor postural control restricts upper extremity functions which also affects the quality of movements. for this reason, it is important to assess the relationship between trunk control and upper extremity functions. this study is planned to investigate the effect of balance and trunk control on upper extremity functions in children with cp.

30 hemiparetic and 32 diparetic cp, in total 62 children, aged between 5-12 years, were included in this study. trunk control measurement scale (tcms) was used to assess trunk control, pediatric balance scale (pbs) was used to assess balance, and quality of upper extremity skills test was used to assess upper extremity functions (quest).

Eligibility criteria:
inclusion criteria: * spastic hemiparetic and / or diparetic cp * co-operative enough to understand test directives * between 5 and 12 years of age * having spasticity of 0-2 according to the modified wax and / or modified ashworth scale (mas) * gmfcs i, ii and iii exclusion criteria: have had previous orthopedic surgery to the upper extremity

Keywords: cerebral palsy trunk control upper extremity
informed decision-making regarding prostate specific antigen (psa) screening in 50-70 year old latino men

Conditions: Prostate Cancer

Summary: the purpose of this intervention trial is aiming to increase inform decision- making in latino men regarding prostate cancer screening. the investigators propose to find out how much latino men know about the benefits and risks of prostate cancer screening and what factors influence how they decide whether or not to have screening. the investigators are also interested in learning how providing education information, both verbally and in print, about the risks and benefits of prostate cancer screening affects men's interest and knowledge. the intervention is an interactive multi-media presentation made up of a small group of 8-10 latino men gathered to discuss about prostate cancer, screening methods, treatment, and the controversy within the medical community regarding psa screening. a facilitator guides the 1-hour discussion and encourages participant interaction. the effect of this intervention was tested on 1000 latino men within los angeles county. participants were recruited from 38 community venues (churches, community center, etc.). all participants were interviewed before being randomized to receive written (control group) or oral (intervention) prostate cancer education material. all of the participants will be followed up at 6-months via a telephone interview. the investigators hypothesize that the intervention group will have an increase knowledge of prostate cancer, will have increase communication with family, friends, and medical provider, and will have an increase rate of psa screening compared to the control group.


Eligibility criteria:
inclusion criteria: * latino men * 50 to 70 years old * not ever having prostate biopsy * not ever having prostate cancer * not having had a psa test within the past 12 months * not having bph (prostate inflammation) * not currently experiencing prostate problems such as pain or burning sensation during urination, blood in urine, and/or desire to urinate frequently exclusion criteria: * not latino * younger than 50 or older than 70 years old * currently experiencing prostate problems such as pain or burning sensations while urinating, blood in urine, and/or desire to urinate frequently * living outside of los angeles county * having had a prostate biopsy * having had prostate cancer previously * having had a prostatectomy

Keywords: psa screening prostate cancer and latino men
health, environment and action in louisville (heal) green heart louisville project

Conditions: Cardiovascular Diseases; Metabolic Health

Summary: the purpose of this study is to examine how the environment and neighborhood characteristics affects the health of the area residents. the study will help determine how changing neighborhood characteristics, such as green space, affect heart health, risk factors for other diseases, sense of well- being or neighborhood cohesion.


Eligibility criteria:
inclusion criteria: * 30-70 years of age. * live within the targeted study location exclusion criteria: * unwilling or unable to provide consent. * hiv/aids, active treatment for cancer, active bleeding including wounds. * body weight less than 100 pounds or bmi\>40. * prisoners and other vulnerable populations. * anyone that pi thinks is unsafe to participate in study.
replication study to analyze the surgical treatment of proximal humeral fracture

Conditions: Proximal Humeral Fracture

Summary: the study at hand aimed to analyze the replicability of the observed treatment effects in these studies published by koeppe et al. and stolberg-stolberg et al.

see protocol

Eligibility criteria:
inclusion criteria: - all patients will be included, who had an inpatient coded treatment using lpf or rtsa exclusion criteria: * incomplete insurance status within two years before index * incomplete basic information * age\<65 years * missing diagnosis of phf (icd: s42.2) within two years before surgery * previous surgical treatment (rtsa, lpf or other fracture fixation) * coded polytrauma * bone tumors/ bone metastasis * both sides or missing information of surgery side * covid-19 infection during index hospitalization
graft patency after ffr-guided versus angio-guided cabg (graffiti) trial

Conditions: Coronary Artery Disease

Summary: this is prospective, randomized, multicenter, multinational, randomized (1:1) study. the aim of this study is to assess the importance of functional assessment of coronary artery disease prior to bypass surgery. in particular, an ffr-guided strategy will be compared to the traditional angio-guided strategy in the guidance of surgical revascularization by aorto-coronary bypass grafting.


Eligibility criteria:
inclusion criteria: * patients with stable angina, unstable angina or nstemi candidate to cabg * significant lad and/or lm lesion - proved by ffr or angiography and * at least one more, angiographycally intermediate lesion exclusion criteria: * significant valvular disease with indication to surgical replacement * severe left ventricular dysfunction (ef\<35%) * acute stemi * atrial fibrillation, if maze procedure is planned