Kornimate/medical-research-clean huggingface dataset:
influence of stabilization splint thickness on the temporomandibular disorders

Conditions: Temporomandibular Disorder; Temporomandibular Joint Disorders; Orofacial Pain

Summary: the aim of the study is assessing the effect of the stabilization splint (ss) thickness on the temporomandibular disorder's and their symptoms; such as muscle or temporomandibular joint (tmj) pain, tmj sounds, and limitation of mouth opening.

participants are selected from patients who applied to the clinic with the complaint of temporomandibular disorders (tmds). symptoms are evaluated with rdc/tmd forms. regarding the treatment plan, patients are divided into two groups; 2 mm-thick splint group (2 mm-tsg) and 4 mm-thick splint group (4 mm-tsg). they used ss's at night for 8 hours, and they were recalled on 1st, 2nd, 3rd, and 6th months after splint insertion. their symptoms and splints are checked.

Eligibility criteria:
inclusion criteria: * no need for orthodontic treatment * maximum 2 teeth have been extracted * having efficient occlusal contacts * patients in the axis 1 and axis 2 groups according to research diagnostic criteria for temporomandibular disorders (rdc/tmd) exclusion criteria: * treated with stabilization splint before * partial edentulous patients * patients in the axis 3 group according to research diagnostic criteria for temporomandibular disorders (rdc/tmd)

Keywords: stabilization splint temporomandibular disorders rdc/tmd temporomandibular joint orofacial pain
intra-individual comparison of conventional and digital pet/ct scanners

Conditions: Breast Cancer; Lung Cancer; Esophageal Cancer; Miscellaneous Neoplasm

Summary: in this study, the investigators will analyze the impact of digital pet/ct on the final diagnostic conclusion of the scan in patients with lung cancer, breast cancer, esophageal cancer and a group of mescellaneous cancers.

there will be a single injection of the pet radiopharmaceutical fdg, followed by a conventional pet/ct scan and a digital pet scan, in this order or vice versa.

Eligibility criteria:
inclusion criteria in order to be eligible to participate in this study, a subject must meet all of the following criteria: * referred to isala for a clinically indicated fdg-pet/ct scan * suspected or proven lung cancer, esophageal cancer, breast cancer or miscellaneous cancer, either as a primary diagnosis or follow-up study * signed informed consent exclusion criteria a potential subject who meets any of the following criteria will be excluded from participation in this study: * age \< 18 years * incapacitated adults * prisoners * pregnant patients * unable to undergo two consecutive pet/ct scans

Keywords: cancer digital pet conventional pet
effects of replacement therapy with sexual steroid hormones on the insulin sensitivity of hypogonadal man

Conditions: Hypogonadism

Summary: sexual steroids administered to supra-physiological doses are likely to change the carbohydrate and lipid metabolism. investigators propose to study in 12 hypogonadal men hypogonadotropic or hypergonadotropic treated with aromatase inhibitor, the respective effects of estradiol, testosterone or both steroids administered in a cross-over latin squares plan on insulin sensitivity measured by the reference method of the hyperinsulinemic euglycemic clamp.


Eligibility criteria:
inclusion criteria: * hypogonadism hypogonadotropic or hypergonadotropic * man aged 18-60 years * bmi between 18 and 27. exclusion criteria: * other ante-pituitary deficiency * chronic treatment modifying carbohydrate metabolism (thiazides, beta 2 mimetics, steroids ...) * diabetes * obesity diffuse or android * hemochromatosis * osteoporosis * chronic diseases * neoplasia * high blood pressure
motivational interviewing with diabetes patients

Conditions: Type 2 Diabetes

Summary: this study was conducted in a quasi-experimental research design with a pretest-posttest control group to determine the effect of motivational interviewing on self-management and hba1c in patients with type 2 diabetes. the sample of the study consisted of 25 experimental and 26 controls, who applied to an outpatient clinic in a training and research hospital.

this study was conducted in a quasi-experimental research design with a pretest-posttest control group to determine the effect of motivational interviewing on self-management and hba1c in patients with type 2 diabetes. the sample of the study consisted of 25 experimental and 26 controls, who applied to an outpatient clinic in a training and research hospital. after the pretest, the experimental group was intervened with a motivational interview (mi) method that consisted of four sessions; the control group received routine treatment.

Eligibility criteria:
inclusion criteria: * 18 years and older * having been diagnosed with type 2 diabetes for more than 3 months * being in the contemplation * preparation, and/or action stages of any section of the behavioral change stage identification form of the trans-theoretical model * having hba1c levels above 6 * agreeing to take part in the study exclusion criteria: * having a perception disorder that will prevent communication * having been diagnosed with any mental disorder

Keywords: type 2 diabetes motivational interviewing hba1c self management
efficacy of pantoprazole in patients older than 18 years who have symptoms of acid reflux (gastroesophageal reflux disease) (by1023/m3-339)

Conditions: Gastroesophageal Reflux

Summary: gastroesophageal reflux disease (gerd) is a medical condition affecting the stomach and esophagus. gerd occurs when the lower esophageal sphincter does not close properly and stomach contents leaks back (refluxes) into the esophagus. gerd is one of the most common medical disorders, with estimates of up to 50% of adults reporting symptoms related to gastric reflux. proton pump inhibitors (ppi) such as pantoprazole can relieve symptoms of gerd in a large proportion of patients. when refluxed stomach acidic content touches the lining of the esophagus, it causes a burning sensation in the chest or throat. this sensation is often referred to as heartburn. some patients have symptoms of gerd without visible destruction of the tissue surface (no visible changes by endoscopic examination). the aim of the study is to evaluate the effect of pantoprazole on the complete remission of gerd. complete remission is defined as endoscopically confirmed healing and symptom relief after a maximum of 12-week treatment period. pantoprazole will be administered once daily in the morning. endoscopy will be performed at the start of the study, and then as required after 4, 8, or 12 weeks. the study will provide further data on safety and tolerability of pantoprazole.


Eligibility criteria:
main inclusion criteria: * outpatients * reflux disease-related symptoms for at least 12 weeks, which need not be consecutive, in the previous 12 months or endoscopically confirmed reflux esophagitis grade a to d, according to la-classification main exclusion criteria: * regular intake of systemic glucocorticosteroids, nsaids including cox-2 inhibitors on \>3 consecutive days per week within the previous 28 days; exception: regular intake of acetylsalicylic acid up to a daily dose of 150 mg/day * intake of ppis (proton pump inhibitor) during the last 10 days, of histamine 2-receptor antagonists or prokinetics during the last 5 days, intake of sucralfate during the last 2 days before the start of the study * intake of ppis in combination with antibiotics for eradication of h. pylori during the last 28 days prior to study start * eradication of h. pylori during the last 28 days prior to study start * acute peptic ulcer and/or ulcer complications

Keywords: gastroesophageal reflux gastroesophageal reflux disease pantoprazole
near-infrared spectroscopy neurofeedback as a treatment for children with attention deficit hyperactivity disorder

Conditions: Neurofeedback; Attention Deficit Hyperactivity Disorder (ADHD)

Summary: to observe the clinical efficacy and mechanism of functional near-infrared spectroscopy imaging neurofeedback therapy for attention deficit and hyperactivity disorder.

in this study, a parallel controlled study will be conducted to recruit 60 patients with adhd, 30 patients in the fnirs group and 30 patients in the drug group. at the same time, 30 healthy controls will be recruited. 6 weeks, 12 sessions of nirs feedback will be given for participants in nirs group and healthy controls. 6 weeks of first or second line medication will be given for participants of drug group. magnetic resonance imaging will be performed at baseline for all participants. snap iv, psq, cgi will be evaluated at baseline, week 3, week 6 and week 8 for adhd participants.

Eligibility criteria:
for adhd patients: inclusion criteria: * diagnosed with td, according to the american diagnostic and statistical manual of mental disorders, 5th edition (dsm-5); * aged 6-12; * right handed; exclusion criteria: * full-scale intelligence quotient below 80(measured by wechsler intelligence scale for children，wisc) * medical or neurological disorders, psychiatric disorders other than oppositional defiant disorder * current participation in a psychotherapeutic treatment

Keywords: nirs fnirs neurofeedback attention deficit hyperactivity disorder (adhd) children
study of mm-398 with or without 5-fu/lv, versus 5-fu/lv in patients with metastatic pancreatic cancer

Conditions: Metastatic Pancreatic Cancer

Summary: the study is an open label, randomized phase 3 study of mm-398 with or without 5-fluorouracil (5-fu) and leucovorin (also known as folinic acid), versus 5-fu and leucovorin in metastatic pancreatic cancer patients who have progressed on prior gemcitabine based therapy.


Eligibility criteria:
inclusion criteria: * histologically or cytologically confirmed adenocarcinoma of the exocrine pancreas * metastatic disease * documented disease progression after prior gemcitabine based therapy * kps \>/= 70 * adequate bone marrow function * adequate hepatic function * adequate renal function exclusion criteria: * active cns metastasis * clinically significant gi disorders * severe arterial thromboembolic events less than 6 months before inclusion * nyha class iii or iv congestive heart failure, ventricular arrhythmias or uncontrolled blood pressure * active infection or uncontrolled fever * pregnant or breast feeding patients

Keywords: pancreatic cancer mm-398 pep02 metastatic pancreatic cancer gemcitabine refractory pancreatic cancer second line pancreatic cancer treatment pancreatic cancer post gemcitabine therapy
correlation between intestinal microbiota, inflamatory biomarkers, intestinal morphology, hepatic fibrosis degree and vascular reactivity.

Conditions: Microbial Colonization

Summary: this project aims to establish the correlation between intestinal microbiota with inflammatory biomarkers, intestinal morphology, vascular reactivity and degree of hepatic fibrosis in patients with different degrees of glucose tolerance and body adiposity.

obese patients with dysglycemia or not, from the obesity outpatient clinic, and individuals with normal or overweight weight with dysglycemia or not, preferably from the same social class and type of diet of the obese will be invited to participate in the study. dysglycemia will be defined by the criteria of the brazilian society of diabetes. these individuals will be divided into four groups: obese with dysglycemia (obd), obese with normoglycemia (ob), lean / overweight with dysglycemia (md) and lean with normoglycemia (m). after the selection and signing of the informed consent, the patient will be referred for an anthropometric evaluation, with the measurement of body mass and height, waist circumference and determination of body fat by the bioimpedance method biodynamic 450 (biodynamics , seattle, usa). finally, the 24-hour reminder (r24h) will be applied as a food survey method. and the dietary calculation will be performed through the avanutri® diet calculation program (rio de janeiro, brazil). clinical parameters will include: age, sex, bmi, presence of comorbidities, use of medications, gastrointestinal complaints, previous surgeries and smoking (absent, present, prior). only after approval by the research ethics committee (cep) of the pedro ernesto university hospital (hupe-uerj), will this recruitment begin.

Eligibility criteria:
inclusion criteria: * men or women between 18 and 50 years old * bmi between 30-40kg / m2 with and without diabetes or altered glucose tolerance * bmi between 18-24.9 kg / m2 without diabetes or altered glucose tolerance exclusion criteria: * acute disease * chronic pulmonary, cardiovascular, haematological, gastrointestinal, hepatic or renal diseases; * unstable dietary history, defined as major changes in diet during the previous month diagnosed by a specialist nutritionist; * history of gastrointestinal disturbances in activity or chronic diseases, including - inflammatory bowel diseases (ibd), chronic diarrhea of unknown etiology, chronic constipation, disabsorbing syndromes, * history of major gastrointestinal tract surgery, except cholecystectomy and appendectomy; * use of the following medications: probiotics in the last 6 months, systemic antibiotics, oral corticosteroids, cytokines, methotrexate or cytotoxic immunosuppressive agents, consumption of large doses of commercial probiotics (greater than or equal to 10 8 cfu or organisms per day) * positive tests for hiv infection and hepatitis b and c; * pregnant and lactating women; * smokers * chronic alcoholism.
vitamin d levels in residents in medicine

Conditions: Vitamin D Deficiency

Summary: the study aims to messure the vitamin d levels in medical staff in the hospital. the physicians in the course of their internship who work indoors and work many night shifts have limited sun exposure in all seasons. nursing staff who work shifts and work indoors are at the same risk of liltle sun exposure. the study addresses the amount of sun exposure, assessed by a sun exposure questioner, age, gender,work load related to number of shifts in the physicien group and in nursing group the job percentile we also adress religion (clothing cover)as a factor.

the population in israel is heterogeneous in the aspect of skin exposure to the sun. women in the moslem community with traditional long sleeve dress code whose sun exposure to the sun even in the summer months is limited. the physicians in the course of their internship who work indoors and work many night shifts and nurses with their shift work have limited sun exposure in all seasons. the study addresses the amount of sun exposure, assessed by a sun exposure questioner, age, gender,number of shifts in the physicien group and in nursing group the job percentile religion (clothing cover). the standard for measuring vitamin d status is 25(oh) d levels in the serum. the staff members from which blood will be drawn will be have an explanation about the aim of the study and will sign an informed consent.

Eligibility criteria:
inclusion criteria:medical staff exclusion criteria:pregnancy
an observational study in children and adults with stargardt disease

Conditions: Stargardt Disease

Summary: this multicenter, prospective, longitudinal, observational study in approximately 80 subjects with stargardt disease secondary to biallelic mutations in the abca4 gene (stgd1) aims to evaluate prognostic factors of disease progression, and to further characterize the patient population for future clinical studies.


Eligibility criteria:
inclusion criteria: 1. male and female subjects between 8 and 50 years of age at the time of enrolment. 2. willingness to adhere to the protocol as evidenced by written informed consent if the subject is 18 years or older. if the subject is under 18 years of age, written assent must be obtained from the subject and written informed consent must be obtained from the subject's legally authorized representative (parent or legal guardian). 3. confirmed mutation in the abca4 gene. exclusion criteria: 1. history of uveitis. 2. any ocular disease in either eye that may confound assessment of the retina morphologically and functionally. 3. any pathology of the posterior segment other than abca4 retinopathy. 4. presence of any other genetic mutation(s) that have been associated with retinal or macular dystrophy.

Keywords: abca4
the efficacy of ultrasound-guided hydrodilatation with hyaluronic acid for patients with adhesive capsulitis

Conditions: Adhesive Capsulitis

Summary: this study was conducted to compare the efficacy of hydrodilatation with hyaluronic acid under ultrasonographic guidance plus physical therapy (pt) with that of pt alone for treating adhesive capsulitis.

adhesive capsulitis is a common cause of shoulder pain, and the efficacy of most interventions is limited. this study was conducted to compare the efficacy of hydrodilatation with hyaluronic acid under ultrasonographic guidance plus physical therapy (pt) with that of pt alone for treating adhesive capsulitis. design: a prospective, single-blinded, randomized, clinical trial patient and methods: patients with adhesive capsulitis for at least 3 months were enrolled and randomly allocated into group 1 (hydrodilatation with hyaluronic acid under ultrasonographic guidance plus pt) and group 2 (pt alone). the patients were evaluated before treatment and were reevaluated 0, 6, and 12 weeks after the beginning of the treatment. outcomes measures included a pain scale (visual analog scale), range of motion, constant shoulder score, shoulder pain and disability index, and the short form-36

Eligibility criteria:
inclusion criteria: 1. a duration of complaints more than 3 months 2. a reduction in passive range of motion in at least 2 of the following: forward flexion, abduction, or external rotation of the affected shoulder of more than 30 degree compared with the other side. exclusion criteria: 1. prior manipulation of the affected shoulder under anesthesia; 2. other conditions involving the shoulder ( rheumatoid arthritis, hill-sachs lesions, osteoarthritis, damage to the glenohumeral cartilage,osteoporosis, or malignancies in the shoulder region); 3. neurologic deficits affecting shoulder function in normal daily activities; 4. shoulder pain caused by cervical radiculopathy 5. a history of drug allergy to hyaluronic acid; 6. pregnancy or lactation; 7. received injection into the affected shoulder during the preceding 3 months

Keywords: adhesive capsulitis hyaluronic acid
trial of linaclotide in patients with irritable bowel syndrome with constipation (ibs-c)

Conditions: Irritable Bowel Syndrome With Constipation

Summary: the objectives of this study are to evaluate the safety, efficacy, and dose response of two delayed release formulations of linaclotide (dr; dr formulation 1 is dr1; dr formulation 2 is dr2) administered orally to patients with irritable bowel syndrome with constipation (ibs-c). additional objectives include understanding how the two dr formulations compare with each other and with the fda-approved 290 μg linzess® (the immediate release \[ir\] formulation of linaclotide).


Eligibility criteria:
inclusion criteria: * patient has completed a colonoscopy according to the american gastroenterological association (aga) criteria, with no clinically significant findings * patient has no clinically significant findings on a physical examination and clinical laboratory tests * patient meets protocol criteria for diagnosis of ibs-c * patient demonstrates continued ibs-c through pretreatment period * patient maintains a minimum level of compliance with daily diary exclusion criteria: * patient has history of loose or watery stools * patient has symptoms of or been diagnosed with a medical condition that may contribute to abdominal pain * patient has a structural abnormality of the gastrointestinal (gi) tract or a disease or condition that can affect gi motility * patient has any protocol-excluded or clinically significant medical or surgical history that could confound the study assessments
columbia shoulder study (css)

Conditions: Osteoarthritis of Glenohumeral Joint

Summary: this prospective study will evaluate the bigliani/flatow prosthesis. the aims of this study are to establish the safety, effectiveness, and value of the prosthetic system, and to collect information from expert shoulder surgeons as to features of the implants, instruments, and techniques which may be further improved. in this study, the investigators hypothesize that this prosthetic device will significantly improve long-term patient-based outcomes, functional status and quality of life.

over the last two decades, total shoulder joint replacement - or arthroplasty - has become a commonly performed procedure for the treatment of painful arthritis of the shoulder, and numerous studies have demonstrated its success. during this time, much has been learned about the efficacy, as well as the complications, of the procedure, and since its introduction in the 1950's, shoulder arthroplasty has undergone an evolution in design. the value of such innovations has not yet been determined and will depend on the results of long term follow-up studies. the purpose of this study is to provide follow-up information and design modification directives.

Eligibility criteria:
inclusion criteria: * patient must be 18 years of age or over. * patient must have signed the informed consent and release of medical information forms. * the patient can be a man, postmenopausal woman, or a woman who is likely to become pregnant but is using adequate contraceptive precautions (defined as oral contraceptives, intrauterine devices, surgical contraception or a combination of a condom and spermicide). * patient needs a total shoulder arthroplasty (humeral head and glenoid). * patient has a diagnosis of primary osteoarthritis. exclusion criteria: * obstacles, which pose an inordinately high surgical risk, in the judgment of the certified surgeon. * class iv or higher anesthetic risk. * patient has a recent history of psychiatric disease (including drug or alcohol abuse) that is likely to impair the compliance with the study protocol. * patient has had a shoulder fracture. * patient had previous shoulder surgeries with the exception of an arthroscopic debridement procedure. * the patients has a massive rotator cuff tear (rupture \>3 cm or total cicatrisation) demonstrated at time of the surgery that precludes the total shoulder replacement.

Keywords: primary glenohumeral osteoarthritis total shoulder arthroplasty total shoulder replacement osteoarthritis multicenter study