Kornimate/medical-research-clean huggingface dataset:
impacts of oral irrigation in patients with periimplant mucositis

Conditions: Peri-implant Mucositis

Summary: the present study aimed to investigate clinically the cleaning effectiveness of different treatment modalities, that is, oral irrigator or interdental brush usage addition to routine brushing and examine tgf-β1, il-1β, t-pa, and pai-1 levels in periimplant crevicular fluid of patients with periimplant mucositis. the null hypothesis was that oral irrigators would be effective compared to interdental brush in the oral care of individuals who use implant-supported protheses.

detailed description: our aim was to evaluate efficacy of a manual tooth-brush with either interdental brush or oral irrigator in treatment of periimplant mucositis. material and method: forty-five patients with periimplant mucositis having at least one implant (age range:45-60) were included in study. study was planned as randomized, single-blind, parallel-design. patients were divided into 3 equal groups; i)toothbrush+oral irrigator ii)toothbrush+interdental brush, iii)only toothbrush. after baseline examinations \[silness-löe plaque index(pi), löe-silness gingival index(gi), probing pocket depth(ppd), clinical attachment level(cal), bleeding on probing(bop)\], initial periodontal therapy was completed using full-mouth disinfection method. periimplant crevicular fluid(pcf) were taken from patents to assess levels of interleukin-1beta(il-1β), transforming growth factor-beta(tgf- β), tissue-type plasminogen activator(t-pa), plasminogen activator inhibitor-1(pai-1). clinical records were repeated at 2, 4 and 12 weeks. the hypothesis of our study is that oral irrigators may be effective in oral care of individuals using an implant-supported prosthesis because of the ease of use.

Eligibility criteria:
inclusion criteria: * subject with no systemic diseases that affect oral tissues and the nature of plaque, * with no professional cleaning for at least six months prior to baseline examination, * with one or more implants (straumann, waldenburg, switzerland) functioning at least 24 months before the start of the study * having implants with bop in at least two of the six regions * the people who agreed to refrain from the use of any nonstudy dental device or oral care product for the study duration were included in the study exclusion criteria: exclusion criteria * subjects not cooperative, * having disease associated with bacteremia, * taking medication influencing gingival health (eg. dilantin, calcium channel blockers, cyclosporine, anticoagulants), * using long-term antibiotic and anti-inflammatory agents, * smokers and * women who were pregnant and in lactation period

Keywords: periimplant mucositis
frequency of tuberculosis in psoriasis patients

Conditions: Psoriasis Vulgaris; Tuberculosis

Summary: aim of this study is evaluation of patients receiving tnf inhibitor therapy in terms of tuberculosis at the end of 15 years in a single center.

aim of this study is evaluation of patients receiving tnf inhibitor therapy in terms of tuberculosis at the end of 15 years in a single center. tnf inhibitor therapy may increase the risk for tuberculosis infection. according to medical data in our hospital in last 15 years, tuberculosis rate of psoriasis patients receiving etanercept, adalimumab and infliximab will be compared.

Eligibility criteria:
inclusion criteria: * psoriasis patients receiving tnf inhibitor therapy exclusion criteria: * patients without tnf inhibitor therapy

Keywords: psoriasis tnf inhibitor tuberculosis
the seea (sci energy expenditure and activity) study

Conditions: Spinal Cord Injuries; Obesity; Metabolic Syndrome; Cardiovascular Diseases; Diet Habit

Summary: people with sci are at higher risk of obesity and chronic diseases, such as hypertension, high cholesterol, diabetes and cardiovascular disease, than the general population. researchers currently lack data on factors that influence weight gain among people with sci. during this one-year observational study, study staff will enroll 60 individuals with sci while they are inpatients at baylor scott \& white institute for rehabilitation (bswir). data will be collected at 3 time periods (before discharge and 6 and 12 months after discharge) in order to better understand factors that affect weight gain over the first 12 months following discharge from inpatient rehabilitation, such as nutritional intake, environmental access, psychosocial factors, energy requirements and risk factors for metabolic syndrome. these data will be used to inform future interventions for people with sci.


Eligibility criteria:
inclusion criteria: * adults ≥18 years with complete or incomplete spinal cord injury (sci) * currently have or are expected to regain enough arm function within 6 months to feed themselves independently. * injury occurred within previous 18 months exclusion criteria: * unwilling or unable to complete repeat assessments * cognitive impairment or brain injury that limits ability to provide data
direct bypass versus indirect bypass in treatment of adults hemorrhagic moyamoya disease

Conditions: Moyamoya Disease

Summary: the investigators conducted a prospective multi-center study assessing the effect of direct bypass and indrect bypass in treatment of hemorrhagic moyamoya disease.


Eligibility criteria:
inclusion criteria: 1. cerebral digital subtraction contrast angiography (dsa) revealed severe stenosis or occlusion of the distal internal carotid or proximal middle and anterior cerebral arteries with prominent lenticulostriate "moyamoya collaterals" 2. patients had experienced at least one intracranial hemorrhage which was verified by computed tomography (ct) scanning, magnetic resonance imaging mri), or lumbar puncture. 3. patients requiring surgery exclusion criteria: 1. patient whose initial onset was marked by ischemia but subsequently suffered from intracranial hemorrhage 2. patients refused to participate in the study

Keywords: hemorrhagic moyamoya disease bypass indirect bypass
trauma informed care for newly resettled refugees

Conditions: Mental Stress; Emotional Stress

Summary: the main purpose of this study is to evaluate early-phase interventions for refugee wellness promotion and build evidence for dissemination of the intervention model and curricula through refugee resettlement programs, local and national.

this study will examine the main effects of trauma-informed case management (ticm) and trauma-informed cultural orientation (tico) interventions, respectively, in reducing resettlement distress and increasing coping capacity, which will improve emotional wellness and social adaptation and thus resettlement outcomes. this project will also test the interaction effects of two-tiered intervention model, discerning effective and ineffective components of the intervention model. differences in effects across intervention conditions may inform how improvement in what outcomes or which phase can affect refugees' wellness and adjustment over time.

Eligibility criteria:
inclusion criteria: * refugee adults who arrive in richmond or charlottesville between january and february 2018 exclusion criteria: -

Keywords: refugee trauma-informed case management (ticm) trauma-informed cultural orientation (tico) ptsd depression refugee resettlement
comparison of phacotrabeculectomy and trabeculectomy in the treatment of primary angle-closure glaucoma (pacg)

Conditions: Glaucoma, Angle-Closure; Cataract

Summary: primary angle closure glaucoma (pacg) is caused by contact between the iris and trabecular meshwork, which in turn obstructs outflow of the aqueous humor from the eye. this contact between iris and trabecular meshwork (tm) may gradually damage the function of the meshwork until it fails to keep pace with aqueous production, and the pressure rises, and at last the optic nerve is damaged, the vision may be lost in some severe cases. therefore, ocular pressure reduction is the key to treat the disease and prevent blindness. trabeculectomy is the most common conventional surgery performed for glaucoma. this allows fluid to flow out of the eye through this opening, resulting in lowered intraocular pressure(iop) and the formation of a bleb or fluid bubble on the surface of the eye. cataract surgery is common in the elderly. cataract surgery is the removal of the natural lens of the eye (also called "crystalline lens") that has developed an opacification, which is referred to as a cataract. cataract extraction includes intracapsular cataract extraction, extra capsular cataract extraction \& phacoemulsification, and phacoemulsification is the preferred method. it has been reported that iop reduction could occur in cataract patients with pacg after the cataract surgery. for some cases with pacg, such iop reduction may be insufficient for neuronal protection, and many patients still require glaucoma medication and incisional surgery such as trabeculectomy to control iop. in such cases, a combined cataract-glaucoma procedure (phacotrabeculectomy) is a reasonable option. in keeping with this concept, previous studies have shown that phacotrabeculectomy could effectively and simultaneously reduce iop and improve vision in patients with a coexistence of pacg and vision-threatening cataract. however, phacotrabeculectomy may heighten inflammatory response, result in a higher frequency of postoperative complications such as hyphema and fibrin in the anterior chamber, endophthalmitis, and increased scarring of the filtering bleb. thus, it is unclear whether phacotrabeculectomy is as effective and safe as trabeculectomy in lowering iop for pacg patients. in the present study, the investigators compared the efficacy and safety of phacotrabeculectomy and trabeculectomy in patients with coexisting pacg and cataract.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of primary angle-closure glaucoma with co-existing cataract exclusion criteria: * secondary glaucoma * history of any intraocular surgery, including laser iridectomy

Keywords: primary angle-closure glaucoma cataract trabeculectomy phacotrabeculectomy
dream2heal: an adaptive stepped-care intervention for chinese cancer survivors with mild-to-moderate insomnia

Conditions: Neoplasm; Sleep Disturbance

Summary: the primary objective of this feasibility study is to assess the feasibility and acceptability, and potential clinical significance of an adaptive stepped-care intervention for improving sleep quality among chinese cancer patients with mild-to-moderate sleep disturbance, using a sequential multiple assessment randomized controlled trial (smart) design.

the primary objective of this feasibility study is to assess the feasibility and acceptability, and potential clinical significance of an adaptive stepped-care intervention for improving sleep quality among chinese cancer patients with mild-to-moderate sleep disturbance, using a sequential multiple assessment randomized controlled trial (smart) design. first, the investigators will test the effect of a low intensity web-based cognitive behavioural therapy for insomnia (cbt-i) intervention (idream2heal; id2h), in comparison to a low intensity web-based exercise intervention (easy exercise; eex). secondly, this study aims to explore if a stepped-up face to face, therapist led cbt-i intervention (d2h) is more effective for patients who continue to have sleep disturbance, in comparison to an augmented intervention, in which is a combined, web-based intervention that covers the content of both id2h and eex interventions.

Eligibility criteria:
inclusion criteria: * cantonese- or mandarin-speaking chinese patients diagnosed with curable breast, colorectal, or gynaecological cancer * completed treatment (except endocrine therapy) within two years * presenting with pittsburgh sleep quality index (psqi) score of 6 to 11 indicating mild-to-moderate sleep disturbance exclusion criteria: * diagnosis of metastatic cancer * current diagnosis of psychiatric disorder * current diagnosis of another sleep disorder, * have received psychological treatment specifically for sleep disturbance

Keywords: sequential multiple assessment randomized controlled trial sleep disturbance cancer survivors insomnia survivorship intervention
asynchronous mindfulness based stress reduction to reduce burnout in licensed clinical social workers

Conditions: Burnout, Professional; Work Related Stress; Quality of Life

Summary: this is a quasi-experimental study that will examine whether mindfulness based stress reduction, adapted to an online learning management system, will reduce factors related to burnout in private practice licensed clinical social workers in new york state.

mindfulness based stress reduction (mbsr) is an evidenced based intervention utilized to reduce stress. in this study, mbsr is adapted as psychoeducational/instructional videos to be viewed on a learning management system by licensed clinical social workers in order to determine its efficacy in reducing symptoms related to burnout in licensed clinical social workers. the videos are 30 minutes in length, and designed to be watched once a day, monday-through-friday, over an eight-week period. additionally, a coaching video of three minutes in length will be available to participants on mondays. participants will watch the videos and engage with the content and activities as prompted by the videos. activities include guided meditations, guided mindfulness activities, such as body scans where participants notice the sensations they feel in various parts of their body, and relaxation exercises. participants will also be asked to complete light exercises to their comfort level, which involves getting comfortable, light self-guided stretching, and relaxation exercises that are no more physical exertion than they otherwise might experience while moving around completing their normal tasks/activities of daily living outside of this program. participants will complete a pre-test involving two validated measures, and several likert scale, non-validated questions, and demographic questions, and a post-test, involving the same two validated measures in the pre-test (in order to determine if a statistically significant change in stress reduction has occurred) as well as completing several non-validated likert scaling questions, and qualitative questions to determine participant's attitudes and beliefs as it relates to their participation in this research project, and their overall impression of the project elements.

Eligibility criteria:
inclusion criteria: * licensed clinical social workers in new york state * working in private practice in new york state exclusion criteria: * anyone who does not hold a license to practice clinical social work in new york state * anyone who is not working in private practice as a licensed clinical social worker in new york state

Keywords: mindfulness mindfulness based stress reduction mbsr burnout stress reduction professional quality of life social work clinical social work private practice
characteristics and treatment outcome of liver abscesses: an observational study

Conditions: Liver Abscess

Summary: 1. to assess the frequency, clinical presentation, microbiological and radiological characteristics of liver abscesses. 2. to evaluate the management plan and treatment outcome of liver abscess. 3. to study risk factors of liver abscess.

there is a paucity of information on liver abscesses' epidemiology and characteristics in the middle east in general and egypt in particular. the incidence of liver abscess varies from one country to another. the annual incidence of pyogenic liver abscess has been estimated at 2.3 cases per 100,000 populations and 18-20 per 100 000 hospital admissions (mohsen et al 2002, kaplan et al 2004). liver abscess is a potentially life-threatening condition (ahmed et al., 2016). a review by chan ks et al. of 16 pyogenic la (pla) articles showed mortality rates ranging from 0% to 15.7 % (chan et al., 2022). the etiology of la can be bacterial (most often polymicrobial), parasitic (amebic essentially), mixed (pyogenic superinfection of parasitic abscess) or more rarely fungal (nakanishi et al., 2009). microbes can invade the liver parenchyma by way of the bile ducts, blood stream (hematogenic, most often portal), or by contiguous spread, especially via the gallbladder bed (yoo et al., 1993, thomsen et al., 2007). advanced age, diabetes mellitus (dm) and the presence of underlying malignancy are considered major risk factors, and the latter is associated with a worse prognosis (yoo et al., 1993, thomsen et al., 2007). the number of cryptogenic liver abscess cases has been on the rise, and no predisposing conditions (cryptogenic) was reported in 18% (mcneil et al. 2020). the diagnosis of la relies essentially on imaging. sonography and ct scan lead to diagnosis in more than 90% of cases (halvorsen et al., 1984).

Eligibility criteria:
inclusion criteria: * diagnosis of la will be based on typical appearance on ultrasound (us) or computed tomography (ct) of abdomen with clinical features consistent with the diagnosis (fever, chills, jaundice, right upper quadrant pain/epigastric discomfort). * us or ct-guided aspiration of pus from a hepatic lesion. * complete resolution of radiological abnormalities following antimicrobial therapy. exclusion criteria: * liver abscess that occurs secondary to hydatid cyst. * liver abscess associated with underlying malignancy. * patient with incomplete medical records.
controlled focal fibrous band release method study

Conditions: Cellulite

Summary: study to evaluate the safety and effectiveness of the avéli medical device to reduce the appearance of cellulite.

multi-center, single-arm clinical study to evaluate the safety and effectiveness of the avéli device in reducing the appearance of cellulite.

Eligibility criteria:
inclusion criteria: * moderate to severe cellulite exclusion criteria: * body mass index ≥30.0
efficacy of music on reduction of sedative drugs in mechanically ventilated intensive care unit patients

Conditions: Sedative Drug Consumption; Mechanically Ventilated ICU Patients

Summary: major objective: a three-days interventional cross-over trial \[one day music on, one day wash-out, one day music off\]\[two periods of listening/day\], to evaluate: 1. impact on sedative drug consumption. 2. alteration of stress neuropeptide blood concentrations. population: mechanically-ventilated icu patients the investigators hypothesize the music will decrease the need of sedative drugs and reduce the concentration of neuropeptides in circulation.

the study will imply patients mechanically ventilated for more than 3 days, that require sedation with benzodiazepine and narcotics. there will be two groups both of exposed to music and placebo (headphones without music). the study will be simple blind. sedation scale will be followed regularly. vitals signs and adjustment of sedation will be recorded by the nurse on the ward. blood test will be taken before and after placement of headphones in the morning. we will measure il-6, cortisol, copeptin, prolactin, crp. we will analyse the total reduction dose of sedation and analgesia on a daily basis. we will consider a fall of 20% of medication to be significative.

Eligibility criteria:
inclusion criteria: * adults older than 18 years old * expected time of mechanical ventilation of more than 72 hours * sedation needs for a scale of sedation-agitation scale (sas) more than 1 exclusion criteria: * hearing impairment * pregnancy * needs of vasopressin * needs of curarisation

Keywords: sedative drug stress music mechanical ventilation il-6 cortisol prolactin crp copeptin
comparison of two preparations for the study of the colon through colonoscopy

Conditions: Colon Cancer; Colon Polyp; Colon Adenoma; Colon Rectal Cancer

Summary: compare the quality of bowel preparation between two groups of patients, who will undergo two different preparations: 1. moviprep + diet; 2. plenvu + diet

the quality of bowel preparation is essential for the success of a colonoscopy, reducing colonoscopy duration, and increasing the rate of cecal intubation and of polyp detection. there are several types of preparations available on the market and, irrespective of the choice, the split-dose regimen should be followed. a reduced volume preparation makes the process easier and more tolerable, increasing adhesion. regarding the diet to be applied before the examination, there are no advantages to a liquid diet compared to a low fiber diet, and there is no evidence on the duration of the diet. in addition, a restrictive diet has an impact on satisfaction and also on adherence to treatment.

Eligibility criteria:
inclusion criteria: * all patients aged \> 18 years and indicated for examination requiring bowel preparation exclusion criteria: * pregnant or breastfeeding women * patients with gastroparesis or gastric obstruction. * patients with psychiatric disorders * severe renal impairment with crcl \<30ml/min * class iii-iv heart failure * dependence / use of laxatives * chronic constipation (\<3 stools/week). * uncontrolled hypertension (sbp \>170mmhg or dbp \>100mmhg) * intestinal obstruction * colostomy from previous intestinal surgery * severe ascites * refusal of participation in the study * patients unable to understand or respond to the satisfaction survey

Keywords: bowel preparation colonoscopy laxative
effect of albumin versus routine care on hemodynamic response and stability in patients with preeclampsia guided by a non-invasive hemodynamic monitoring system during cesarean delivery with spinal anesthesia

Conditions: Pre-Eclampsia

Summary: the purpose of this study is to compare the effect of albumin versus routine care on hemodynamic response and stability in pre-eclamptic patients during cesarean delivery. the hypothesis is that volume replacement with albumin guided by stroke volume variation (svv) using a clearsight-acumen (cs-a) monitor, before cesarean delivery (cd), improves hemodynamic stability in preeclamptic patients with severe features compared to routine care, under neuraxial anesthesia.


Eligibility criteria:
inclusion criteria: * gestational age greater or equal to 24 weeks * diagnosis of preeclampsia with severe features \[pre-eclampsia is defined as high blood pressure after 20 weeks with or without proteinuria. pre-eclampsia with severe features is defined as the presence of preeclampsia with any of the following features: severe hypertension (blood pressure ≥160/110 mmhg on two separate occasions); thrombocytopenia (platelet count \ 1.1 mg/dl or doubling of the serum creatinine level in the absence of other renal disease; pulmonary edema or unexplained new-onset cerebral symptoms (headache) unresponsive to medications or visual disturbances.\] * scheduled cesarean delivery * unscheduled cesarean delivery with the goal to proceed to the operating room within no less than 30 minutes due to concern for maternal or fetal status that is not immediately life threatening. * requiring neuraxial anesthesia (spinal or cse) exclusion criteria: * patient declines to participate in the study * labor * contraindications to the use of neuraxial anesthesia (coagulopathy, infection at the insertion site, intracranial mass etc.) * unscheduled cesarean delivery with the goal to proceed to the operating room immediately for delivery of the baby due to imminent/unavoidable threat to the life of the mother or fetus. * the use of or conversion to general anesthesia * non-reassuring fetal status including the presence of cardiac or multi-system anomalies, category iii tracing etc. * significant maternal cardiopulmonary disease including pulmonary hypertension, ischemic heart disease with systolic dysfunction, pulmonary edema etc. * significant intraoperative events (such as hemorrhage) requiring administration of multiple blood products and icu admission.

Keywords: pre-eclampsia albumin hemodynamic