Kornimate/medical-research-clean huggingface dataset:
remote exercise programs in chronic low back pain

Conditions: Low Back Pain

Summary: low back pain is a common problem that affects many people at some point in their lives. these people constitute a big part of the disease burden due to their recurrent complaints. about 45% of individuals with chronic low back pain seek medical attention. this situation makes chronic low back pain the second reason for individuals to apply to the hospital. exercise therapy is the first option that comes to mind in the management of low back pain. it is seen that exercise therapy both reduces the intensity of pain and reduces the recurrence rate of complaints. when the literature is examined, it is observed that among the exercise models, stabilization exercises can provide more benefits than general exercises in reducing pain and improving disability. the covid-19 pandemic causes disruptions in face-to-face rehabilitation services. the development of telemedicine and telerehabilitation services, whose popularity is increasing with the advancing technology, gained momentum with these disruptions. with telerehabilitation, long-term treatments tailored to the needs of the patients can be offered, the cost is low, and the patients can exercise at home, on their own, at their own pace, whenever they want. these reasons make telerehabilitation stand out especially during the pandemic period. the aim of the study planned in this context is to investigate short and long-term results of remote and face-to-face exercise training on function and disease symptoms for individuals with chronic low back pain.


Eligibility criteria:
inclusion criteria: * having low back pain for more than 3 months, * pain intensity of 3 or more according to vas, * literate, * a smartphone user, * own a smartphone * individuals who are able to understand the exercises (total score \>21 on the montreal cognitive assessment scale (moca)) will be included in the study. exclusion criteria: * those who have been diagnosed with cervical or lumbar region pathologies, * cervical rapiculopathy, thoracic outlet syndrome, * having a malignant condition, * having systemic diseases such as neurological, psychological, cardiovascular, rheumatological and loss of function due to these diseases, * history of previous surgery on the spine and upper extremity, * acute infection, * individuals who do not agree to participate in the study and do not give written consent will be excluded from the study.

Keywords: spinal stabilization exercise tele-rehabilitation low back pain
study of medication for nonallergic rhinitis (nar) based on cluster analysis

Conditions: Determination of the Efficacy of Different Medications for Idiopathic Rhinitis; Impact of Different Medications on Biomarkers of Idiopathic Rhinitis; Safety and Tolerance of Different Medications for Idiopathic Rhinitis

Summary: chronic rhinitis (cr) is one of the most common nasal mucosal diseases in the world. in china, about 140 million people suffer from this disease. chronic rhinitis can lead to severe economic and social burden, as well as the potential risk of developing other chronic diseases such as asthma and chronic sinusitis. therefore, it is of great significance to explore the classification and treatment strategies of chronic rhinitis in order to improve the health level of chinese people.


Eligibility criteria:
inclusion criteria: * not younger than 18 years old * diagnosed as idiopathic rhinitis * signed and volunteered for the study exclusion criteria: * comorbid airway diseases including (but not limited to) upper airway infection, chronic rhinosinusitis, nasal polyps * allergic to the medicines about to study * having used oral glucocorticoids or antihistamine agents within 30 days of the enrollment
in vivo characterization of macrophages in pediatric patients with malignant brain tumors using ferumoxytol-enhanced mri

Conditions: Childhood Brain Neoplasm

Summary: this pilot early phase i trial studies how well ferumoxytol-enhanced magnetic resonance imaging (mri) correlates with inflammatory (macrophage) responses in pediatric patients with malignant brain tumors. if there is good correlation, ferumoxytol-enhanced mri can serve as a noninvasive imaging biomarker of inflammation.

primary objective: i. to establish the magnetic resonance (mr) imaging signal characteristics of macrophages in pediatric patients (\>= 2 years old) with newly diagnosed malignant brain tumors using ferumoxytol, an ultrasmall superparamagnetic iron oxide (uspio) particle. secondary objectives: i. to correlate the mri signal of ferumoxytol uptake in macrophages with the number of macrophages in surgical tumor specimen at histopathology. outline: patients receive a single intravenous infusion of ferumoxytol over 15 minutes. after 24 hours, patients undergo ferumoxytol-enhanced magnetic resonance imaging (mri). patients will then undergo mri-localized tissue sampling and tumor resection.

Eligibility criteria:
inclusion criteria: * any patient with suspected malignant brain tumor on diagnostic mr imaging who will undergo a resection exclusion criteria: * informed consent cannot be obtained either from the patient or legal representative * severe coexisting or terminal systemic disease that may interfere with the conduct of the study * contraindication to mri (metal implants) * hemosiderosis/hemochromatosis * iron overload from any cause (not just hemosiderosis or hemochromatosis), even if secondary to frequent blood transfusions, severe chronic hemolysis, excess dietary or parenteral iron, or any other etiology * known hypersensitivity to ferumoxytol or any of its components * pregnant patients
study to evaluate efficacy, safety and tolerability of lyrica in patients with painful diabetic peripheral neuropathy

Conditions: Diabetic Neuropathy, Painful

Summary: pregabalin has proven effective in previous clinical trails in other countries in relieving neuropathic pain associated with postherpetic neuralgia and painful diabetic neuropathy. this study is being conducted according to china registration requirement to submit a reapplication with new local diabetic peripheral neuropathy study as a commitment plus the existing data to apply for lyrica "pain associated with postherpetic neuralgia" indication after lyrica "pain associated with postherpetic neuralgia" is approved.


Eligibility criteria:
inclusion criteria: * male and female subjects aged 18 years or older * diagnosis of painful, distal, symmetrical, sensorimotor polyneuropathy which is due to diabetes mellitus (type 1 or 2), and symptoms of painful diabetic neuropathy for 6 months to 5 years (inclusive). * at the baseline and randomization visits, a score of ≥50 mm on the visual analogue scale, at randomization, subjects must have completed at least 5 daily pain interference diaries, and have an average daily pain score of ≥5 over the past 7 days. * patient who are willing and capable to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures. * women of childbearing potential are willing to use contraception during study. exclusion criteria: * subjects with more than 30% decrease on the pain visual analog scale at randomization as compared to screening; and during the 1 week screening period, with more than one pain score \<3 in pain scores. * subject has other kinds of neurological disorder, pain of other reason, or skin condition that could confuse the assessment. * subject with any other serious or unstable condition which in the opinion of the investigator might compromise participation in the study.

Keywords: diabetic neuropathies pain efficacy of pregabalin placebo controlled
effect of flamingo exercises on balance

Conditions: Osteoarthritis; Gait Disorders, Neurologic

Summary: the aim of this study is to determine the effect of flamingo exercise on balance in patients with balance impairment due to senil osteoarthritis

changes in the sensory, neurological, and musculoskeletal systems in older adults affect several motor tasks,including postural balance. also osteoarthritis contribute to this process. older people can gain balance disorders. the flamingo balance exercise is a full lower body workout utilizing many major muscle groups. therefore investigators aimed to determine the effect of flamingo exercise combined with kinesthetic ability trainer or alone in patients with balance impairment due to osteoarthritis

Eligibility criteria:
inclusion criteria: * older than 65 years old * osteoarthritis diagnosis * balance impairment (berg balance scale 21-40 points) exclusion criteria: * severe neurological deficit * defect of vision * vitamin b12 deficiency * sedative drug use
cytokines and chemokines in erythema migrans

Conditions: Erythema Migrans

Summary: the main objective of this study is to characterize the inflammatory proteins, gene polymorphisms, and transcriptome profiles in patients with erythema migrans to gain better insight into pathogenesis of early lyme borreliosis and to define new immune modulators that could serve as biomarkers of disease activity.


Eligibility criteria:
inclusion criteria: * erythema migrans in patients \> 18 years exclusion criteria: * pregnancy or lactation * taking antibiotic with antiborrelial activity within 10 days

Keywords: erythema migrans lyme borreliosis inflammation outcome
pregnancy, sleep disordered breathing and peripartum complications

Conditions: Sleep Apnea; Pregnancy

Summary: sleep disordered breathing (sdb) during pregnancy is a modifiable risk factor for poor maternal and fetal outcomes. the investigators propose a prospective observational study to assess the utility of continuous positive airway pressure (cpap) administration (intervention) during pregnancy to reduce maternal and fetal morbidity. secondarily, we will also perform a cohort study to assess the incidence of antenatal sleep-disordered breathing as measured by ambulatory sleep monitoring applied in the hospital setting.

hypothesis: cpap application in sdb-diagnosed parturients will decrease fetal and maternal morbidity. specific aims: 1. to screen women after their first trimester of pregnancy that are at risk for carrying babies with fetal growth restriction (fgr) for presence of sdb (fgr is commonly diagnosed at 20 weeks gestation by ultrasound as standard of care) and to follow their diagnosis and treatment with cpap, as per standard of care, for the remainder of their pregnancy or order to follow fetal and maternal outcomes. a. screen = parturients affirm presence of snoring. b. screen positive parturients are further assessed with 1-2 nights of ambulatory sleep and respiration monitor to confirm sdb b. sdb positive parturients are offered treatment, as per standard of care, with cpap. c. screen positive parturients are reassessed with 1-2 nights of ambulatory sleep monitoring (whether or not cpap is eventually applied) at two more intervals during pregnancy (during second and third trimesters), and then 6-8 weeks after delivery. this study is designed as a prospective observational cohort study in order establish the concurrence of the disease (sdb) as it occurs with the increased "risk" or exposure to the vulnerable state (pregnancy) and presence of diagnosed fetal growth restriction. in addition, parturients who test positive for sdb will be assessed by a pulmonologist and offered standard of care therapy with cpap, as appropriate. cpap use will then be followed and assessed as a mitigating intervention to blunt fetal growth restriction. this study is a pilot in that we hope to establish the incidence of co-morbidities in order to appropriately plan for an adequate sample size in future intervention studies. given the large overall parturient population that will be available to the study team, we believe that in one calendar year we will observe sufficient patients to establish the relationship of sdb during the antenatal pregnancy and fetal growth restriction.

Eligibility criteria:
inclusion criteria: * i. prepartum * 18 years of age and older, able to provide informed consent * pregnant * diagnosis of fetal growth restriction (by ultrasound) exclusion criteria: * • patient refusal * inability to provide informed consent * known maternal severe cardiopulmonary disease * known fetal anomalies
role of interleukin 18 (il-18) and interleukin 18 binding protein (il-18bp) in the diagnostic work-up of systemic juvenile idiopathic arthritis and autoinflammatory diseases: possible biomarkers in the differential diagnosis of other febrile diseases

Conditions: Systemic Juvenile Idiopathic Arthritis (sJIA)

Summary: literature data suggest that elevated blood values of il-18 and il-18 binding protein and alterations in their ratio may be significantly correlated with various autoinflammatory diseases, such as systemic juvenile idiopathic arthritis, recurrent autoinflammatory fevers etc. in this view, the clinical implication of this observational, prospective, single-centre, non-pharmacological study will be the definition of new laboratory markers that may be useful in the early differential diagnosis of certain rare and serious paediatric diseases.

the primary aim of this study is to investigate the role of il-18 and il-18 binding protein as biomarkers of systemic juvenile idiopathic arthritis and recurrent autoinflammatory fevers, while the secondary one is to investigate the superiority of il-18 and il-18 binding protein over other cytokines and inflammatory indexes in the differential diagnosis of systemic juvenile idiopathic arthritis and recurrent fevers of an autoinflammatory nature. the study will enroll patients referred to the pediatric rheumatology outpatient clinic of the pediatrics unit, irccs azienda ospedaliero-universitaria of bologna, italy, for suspected juvenile idiopathic arthritis or suspected recurrent fever/self-inflammatory disease. patients will be enrolled during the acute phase of the disease and, prior to the start of immunosuppressive therapy (i.e. corticosteroids, colchicine, biological drugs), a blood sample will be taken for haematochemical investigations, according to clinical practice, as well as an additional blood sample for the assay of il-18 and il-18 binding protein. the following variables will be considered for each patient: demographic data; key clinical features; haemochromocytometric test; liver and kidney function tests; indexes of inflammation and acute phase proteins; inflammatory cytokines panel; serum values of il-18 and il-18 binding protein.

Eligibility criteria:
inclusion criteria: * age between 2 years and 18 years; * being affected by 1 of the following: juvenile idiopathic arthritis; recurrent fever/ autoinflammatory disease; rheumatic disease; severe infectious diseases (sepsis, meningitis, urinary tract infection, lower respiratory tract infection); * obtaining informed consent from parents/legal guardians of paediatric patients. exclusion criteria: • patients in whom the suspicion of rheumatic disease is based on a finding of subclinical carditis or chorea.

Keywords: systemic juvenile idiopathic arthritis
'4c' intervention to reduce sars-cov-2 (covid-19) transmission

Conditions: SARS-CoV Infection; Covid19

Summary: nursing homes have long faced special challenges in implementing effective infection prevention programs, including limited resources and diagnostic challenges in a frail functionally disabled long-stay population. advancing our understanding of the transmission of sars-cov-2 within these facilities for vulnerable populations deserves urgent and further investigation. environmental contamination with sars-cov-2 that is reported in limited studies highlights the potential importance of transmission between patients, their environment, and healthcare providers via direct and indirect contact. this study seeks to characterize the epidemiology of sars-cov- 2 in the nh patient room environment over time and the risk of transmission to near and far environments, with the explicit intent of developing integrated, simple covid-19 infection prevention strategies that can be reported to and implemented throughout other nursing homes and long-term care facilities.

in order to achieve these goals the study is being performed at four different nursing homes and will include patients with active or with recent covid-19 infection, as well as nursing home staff members. the study will test a multimodal aging-friendly intervention including four components and hypothesizes that the implementation of this organizational, educational, quality improvement program will be associated with lower odds of sars-cov-2 transmission to the environment.

Eligibility criteria:
inclusion criteria for nursing home patients: * 18 years of age or older * residing in a participating nursing home facility * active or recent (last 14 days) covid-19 infection exclusion criteria for nursing home patients: * not located in a participating nursing home facility inclusion criteria for healthcare workers: - healthcare worker at a participating nursing home facility exclusion criteria for healthcare workers: - none

Keywords: environmental contamination nursing home interventions
prospective evaluation of the recell® autologous cell harvesting device for specific compassionate use cases

Conditions: Burns

Summary: this is a prospective uncontrolled observational study to evaluate clinical outcomes following use of the recell autologous cell harvesting device (recell) as an adjunct for closure (re-epithelialization) as a treatment of life-threatening wounds requiring grafting for closure, and associated skin graft donor sites, in patients who lack adequate available skin to harvest for conventional grafting. treatment with the recell device may be performed as part of a single operative procedure, or multiple staged procedures as deemed clinically necessary. adverse events associated with the use of the recell device/cell suspension will be documented. subjects will be followed for 1 year following recell treatment.


Eligibility criteria:
inclusion criteria: * the patient requires treatment of a life-threatening wound requiring grafting. * patient has inadequate available skin to harvest for conventional skin grafting. * the treating investigator has determined 1) that there is no suitable alternative therapy that would be adequate to meet the patient's medical need; and 2) the risk associated with use of the recell device is no greater than the probable risk from the disease or condition. * in the treating investigator's opinion and with consideration of the severity of the patient's health status, the patient has the potential to realize benefits from the application of the recell device. * patient is hemodynamically stable. * the patient (or legal representative) is able to read and understand instructions and give informed consent. exclusion criteria: * the patient has active infection at the proposed recell treatment site. * the patient is unable to follow the protocol. * the patient has a known hypersensitivity to trypsin or compound sodium lactate for irrigation (hartmann's) solution.
safety and performance of princess® volume for the treatment of facial lipoatrophy, asymmetry or scars

Conditions: Facial Lipoatrophy; Morphological Asymmetry of the Face; Debilitating Scars

Summary: in this study, eligible patients with the medical indications (facial lipoatrophy, morphological asymmetry of the face, or debilitating scars) will be treated with princess® volume, and then will return for follow-up assessments 2, 4, 24, and 36 weeks after the treatment. a touch-up treatment may be done 2 weeks after the treatment if deemed appropriate by the investigator.


Eligibility criteria:
inclusion criteria: * male or female 18 years of age or older * presence of a defect, which in the opinion of the investigator can be corrected by a dermal filler, and is caused by: ° facial lipoatrophy of moderate severity, or * morphological asymmetry of the face, or * one or more debilitating scars on the face * willingness to abstain from any cosmetic or surgical procedures in the treatment area for the duration of the clinical investigation * willingness to take part in the clinical investigation as evidenced by a personally signed informed consent. exclusion criteria: * pregnancy, breastfeeding, or unwillingness to use contraception throughout the clinical investigation (for women of child-bearing potential only) * history of allergic reaction or hypersensitivity to hyaluronic acid * history or presence of any autoimmune or connective tissue disease, or current treatment with immune therapy * presence of silicone implant or other non-absorbable tissue filler in the area targeted for intervention, or pre-treatment with any hyaluronic acid filler within the last six months * presence of infectious, inflammatory, or proliferative lesions in the area targeted for intervention * treatment with anticoagulant or antiplatelet drugs * any disease or condition which, in the investigator's opinion, represents a safety risk for participation in the study * current participation in another clinical trial, or previous treatment with any investigational drug/device within 30 days prior to enrolment * institutionalized persons with legally limited civil rights
effects of combined cycle training and inspiratory muscle training in patients with copd

Conditions: Chronic Obstructive Pulmonary Disease (COPD)

Summary: chronic obstructive pulmonary disease (copd) ，the fourth leading cause of death in the world, represents an important public health challenge. it is also a major cause of chronic morbidity, mortality and disability throughout the world, leading to a heavy social and economic burden. for a long time, treatment of copd mainly focus on drug therapy. recently, pulmonary rehabilitation is recognized as a core component of the management of individuals with chronic respiratory disease, which has been clearly demonstrated to reduce dyspnea, increase exercise capacity, and improve quality of life. exercise training, widely regarded as the cornerstone of pulmonary rehabilitation , is one of the best available means of improving muscle function in copd.the most commonly form is cycle training. inspiratory muscle training (imt) as an adjunct to exercise training has an additional benefit on inspiratory muscle strength, endurance and exercise capacity in patient with copd. there is insufficient evidence demonstrate greater benefits from combined inspiratory muscle training and cycle training. this study will evaluate the effects of combined inspiratory muscle training and cycle training in patients with copd.

the patients with copd will participate in a rehabilitation program for 8 weeks. participants in the proposed study will be randomly programmed into one of three intervention groups: 1. cycle training program alone (performing on calibrated stationary cycle ergometer). 2. combined cycle training and inspiratory muscle training(performing on calibrated stationary cycle ergometer and threshold loading device). 3. neither cycle training nor inspiratory muscle training.

Eligibility criteria:
inclusion criteria: * patients between 40 and 75 years of age were eligible if they met the following criteria: * moderate to severe airflow obstruction (30≤ forced expiratory volume at one second(fev1) \<80% predicted and forced expiratory volume at one second/forced vital capacity(fev1/fvc)\<70%) * complaints of dyspnea on exertion * clinically stable condition * no participation in a pulmonary rehabilitation program in the last year. exclusion criteria: * patients were excluded if they had evidence of asthma and/or had experienced a major exacerbation in the 2 months before enrollment * required home oxygen therapy or experienced oxyhemoglobin desaturation below 85% with exercise * and/or had other health problems that would interfere with exercise.

Keywords: pulmonary rehabilitation inspiratory muscle training exercise training