Kornimate/medical-research-clean huggingface dataset:
the effects of active warming on temperature on core body and thermal comfort

Conditions: Postoperative Hypothermia; Thermal Comfort; Body Temperature Changes

Summary: purpose: this study was conducted to examine the effect of warmed intravenous fluids (wivf) on the core body temperature and the patients' thermal comforts during the postoperative period in patients undergoing transurethral resection of the prostate (turp). design: this was a prospective, randomized controlled experimental study. methods: a total of 105 male patients undergoing turp surgery and bladder irrigation were randomized to one of either room temperature (n=51) or warmed intravenous fluids (n=54) groups in postanesthesia care unit. the fluids in the experimental group were warmed until the body temperature was reached 36.0°c.

purpose: this study was conducted to examine the effect of warmed intravenous fluids (wivf) on the core body temperature and the patients' thermal comforts during the postoperative period in patients undergoing transurethral resection of the prostate (turp). design: this was a prospective, randomized controlled experimental study. methods: a total of 105 male patients undergoing turp surgery and bladder irrigation were randomized to one of either room temperature (n=51) or warmed intravenous fluids (n=54) groups in postanesthesia care unit. the fluids in the experimental group were warmed until the body temperature was reached 36.0°c. the intravenous (iv) fluid given to the two groups was 1000 ml of 0.9% isotonic sodium chloride solution.

Eligibility criteria:
inclusion criteria: * patients who age bigger than18, * patients who were undergoing general anesthesia, to whom voluntary hypothermia was not applied during the operation, * patients who were hemodynamically stable, * patients who had a physician's order for 1000 ml of 0.9% isotonic sodium chloride iv fluid treatment, * patients were undergoing bladder irrigation were included in the study. * patients the sense, expression of heat by the patient in recovery, * patient who accepted to participate to the study exclusion criteria: * patients have any infection, fever * patients have underlying diseases (hypothyroidism, hyperthyroidism, diabetes, cardiovascular disease or kidney failure) * patients who had mental deficiency that could prevent communication, * patients who had visual or hearing impairments, * patients who were receiving mechanical ventilation support, were sedated, * patients were the need for open surgery or any reason for returning the patient to the operating room, * patients need for postoperative blood transfusions, * patients have intra-abdominal infection, * patients have an unexpected allergy to anesthetic drugs, * patients have a temperature higher than 36.0ºc, * patients have for cardiopulmonary resuscitation, * patients have severe hemodynamic changes during the operation.

Keywords: fluid infusion postoperative hypothermia nursing active warming
ezopiclone improves the quality of overnight polysomnography

Conditions: Obstructive Sleep Apnea

Summary: patients often have difficulty sleeping during overnight sleep testing in a lab environment. the purpose of this study is to determine if taking a sleep aid will improve sleep and therefore the quality of the sleep study.

the increasing awareness of sleep-disordered breathing (i.e obstructive sleep apnea) has created a growing demand for polysomnography (sleep study), resulting in excessive waiting times in many laboratories. sleep centers have therefore needed to develop methods to improve their efficiency. unfortunately many patients find it difficult to fall asleep in the unfamiliar environment of a laboratory setting (the "first-night effect"), circumstances that may prolong falling alseep and staying sleep. likewise, intolerance of continuous positive airway pressure (cpap) may also reduce the quality of the sleep study. poor quality studies may lead to an inability to make a diagnosis or adequately titrate cpap therapy. unsatisfactory studies may need to be repeated. sleep aids (hypnotics) are commonly used to treat both acute and chronic insomnia. these agents have minimal side-effects and do not disrupt normal sleep architecture or alter respiratory events. these attributes make such agents ideal for use to improve the quality of sleep studies and enhance the efficiency of sleep centers. in a recent retrospective review, we found that the use of a hypnotic prior to the sleep study resulted improved patient satisfaction and improved quality of the sleep study with significantly less studies needing to be repeated. although promising, these results must be validated with a prospective, randomized, placebo-controlled trial. eszopiclone (lunesta) is a new non-narcotic, non-benzodiazepine hypnotic agent which received fda approval on december 15, 2004 for the treatment of acute and chronic insomnia. multiple clinical trials have found that eszopiclone decreases sleep latency, improves sleep efficiency/maintenance and reduces wake time after sleep onset (waso). given its efficacy in promoting sleep onset and sleep maintenance and its excellent safety profile, this agent should be ideal as a pre-study sedative. the purpose of this study is to validate the use of lunesta in improving the quality of overnight sleep studies.

Eligibility criteria:
inclusion criteria: * all adult patients aged 18-65, evaluated by a sleep medicine provider in the walter reed army medical center sleep disorders clinic, who are referred for psg for suspected obstructive sleep apnea syndrome exclusion criteria: * pregnancy * liver dysfunction or history of etoh abuse * concomitant use of benzodiazepines, narcotics or ketozonazole * decompensated chf * cva within 3 months * uncontrolled psychiatric disorders * patients \< 18 years old * patients over 65

Keywords: obstructive sleep apnea polysomnography non-benzodiazepine hypnotics
influence of bag volume variation on the reproducibility of inert gas rebreathing

Conditions: Chronic Obstructive Pulmonary Disease; Bronchial Asthma; Restrictive Pulmonary Disease

Summary: non-invasive inert gas rebreathing (igr) based on the fick principle showed promising results in the determination of pulmonary blood flow (pbf). the volume of the rebreathing bag (vbag) is proposed by the system, however, elderly patients or those suffering from high grade pulmonary diseases might be unable to entirely rebreathe this volume and therefore fail to completely mix the test gases. the aim of our study is to evaluate the effect of adapting vbag on the reproducibility of igr measurements in patients with obstruction (group a), restriction (group b) and pulmonary healthy controls (group c).


Eligibility criteria:
inclusion criteria: * ability to perform rebreathing maneuver exclusion criteria:
in vitro activity of tigecycline among key bacterial pathogens exhibiting multidrug resistance

Conditions: Infections, Bacterial

Summary: observational: studies in human beings in which biomedical and/or health outcomes are assessed in pre-defined groups of individuals. subjects in the study may receive diagnostic, therapeutic, or other interventions, but the investigator does not assign specific interventions to the subjects of the study.

study phase definition: phase of investigation, as defined by the us fda for trials involving investigational new drugs. select only one. n/a: for trials without phases observational study design case-control: group of individuals with specific characteristics (e.g., conditions or exposures) compared to group(s) with different time perspective cross-sectional: observations or measurements made at a single point in time, usually at subject enrollment biospecimen retention - select one samples without dna - samples retained, with no potential for dna extraction from any retained samples (e.g., fixed tissue, plasma) biospecimen description sputum, whole blood, urine, tissue enrollment single group study number of groups/cohorts definition: number of study groups/cohorts. enter 1 for a single-group study. many observational studies have one group/cohort; case control studies typically have two. one study group, anticipated samples in the rang of 400-500 samples 8. arms, groups and interventions n/l group/cohort label

Eligibility criteria:
inclusion criteria: * all patients with infection with mdrs infections will be included exclusion criteria: * none

Keywords: tigecycline, mdr patient infected with multidrug resistance bacteria
safety and efficacy evaluation of im19 car-t cells (im19car-t)

Conditions: Leukemia

Summary: assessment of the safety and feasibility of administering t cells expressing an anti-cd19 chimeric antigen receptor to patients with cd19+ b-cell leukemia.

assessment of the safety and feasibility of administering t cells expressing an anti-cd19 chimeric antigen receptor to patients with cd19+ b-cell leukemia and determine the best dosage.

Eligibility criteria:
inclusion criteria: 1. patients with cd19+ refractory or relapsed b-all（at least 2 prior combination chemotherapy regimens） 2. to be aged 3 to 75 years 3. blast in blood ≤ 30% 4. ecog score ≤2 5. women of childbearing potential must have a urine pregnancy test taken and proven negative prior to the treatment. all patients agree to use reliable methods of contraception during the trial period and until follow-up for the last time. 6. voluntary participation in the clinical trials and sign the informed consent. exclusion criteria: 1. intracranial hypertension or unconsciousness 2. respiratory failure 3. cd19 negative 4. disseminated intravascular coagulation 5. alt /ast\>3 x normal value; creatinine\> 1.5 x normal value; bilirubin \>2.0 x normal value 6. hematosepsis or uncontrolled active infection 7. uncontrolled diabetes 8. abalienation; 9. who sscore \>3 10. patients in pregnancy or breast-feeding period 11. previously treatment with any gene therapy products 12. any uncontrolled medical disorders that the researchers consider are not eligible to participate the clinical trial 13. any situation that would increase dangerousness of subjects or disturb the outcome of the clinical study according to the researcher's evaluation.
a study to collect intravascular ultrasound images before and after treatment with the jetstream system

Conditions: Peripheral Arterial Disease; Peripheral Vascular Disease

Summary: the jetstream system is a commercially available rotating, aspirating, expandable catheter designed to remove atherosclerotic plaque and blood clots in the lower limbs. the purpose of this study is to use intravascular ultrasound (ivus) during the interventional procedure to measure the amount of plaque and blood clots removed by the jetstream system.


Eligibility criteria:
inclusion criteria: * the patient is ≥ 18 years of age. * the documented peripheral vascular disease is/are located in a superficial femoral, popliteal or tibial peroneal trunk arteries in the lower limb. * the patient is an acceptable candidate for percutaneous intervention using the jetstream g2 system in accordance with its labeled indications and instructions for use. * the patient has been informed about the nature of the study and has provided informed consent. exclusion criteria: * patient has no distal runoff. * interventional treatment is intended for in-stent restenosis at the peripheral vascular site. * patient is pregnant or nursing a child. * intended interventional treatment includes planned laser, brachytherapy or atherectomy procedure other than the jetstream g2 system. * patient has clinically significant abnormal ecg or blood test results or any other factor that would put the patient at increased risk if participating in the study.

Keywords: peripheral arterial disease peripheral vascular disease
identification of biomarkers related to liver fibrosis as new therapeutic targets

Conditions: Hepatopathy; Fibrosis

Summary: fibrosis is a dynamic process resulting from the balance of fibrogenesis and fibrolysis, mainly secondary to chronic necro-inflammation related to regular alcohol consumption, metabolic syndrome (nash) or viral hepatitis. the liver has the property of allowing the reversion of fibrosis / cirrhosis when the necrotic-inflammatory activity is controlled. the balance between fibrosis / fibrolysis and its inhibition depends on many pathways and the hypothesis of the efficacy of a single treatment remains uncertain. molecular factors in the progression of liver fibrosis should be determined. it is necessary to control the liver fibrosis and thus reduce the risk of carcinoma in this population. the anti-fibrotic drugs are being developed, but so far only alpha-tocopherol and obeticholic acid have been shown to have a significant anti-fibrotic effect in humans. several new drugs are currently being evaluated in ongoing phase 2 and 3 randomized clinical trials, but most of them have intrinsic limitations: (i) they take a long time for evaluation (\> 3 years), ( ii) they generally require an histopathological evaluation by serial liver biopsies that are invasive and unpopular with patients who are aware of noninvasive tests for fibrosis assessment and (iii) treatment is often a single treatment versus a placebo group with the uncertainty that at 1 or 3 years, serial liver biopsies results are convincing.

the study will be performed in 30 patients. patients will be enrolled in two investigators sites (cochin hospital, pitie-salpetriere hospital, france) where the patient selection will be conducted during a multidisciplinary collaborative meeting. the patients will be enrolled after collecting their informed consent. as soon as the patient is included, arrangements will be made for the organization of the liver resection according to the usual procedure of the hospital department. the biological samples for the research (blood and liver) will be taken at the time of the surgery and sent to the research unit (institut pasteur) where immunological analyses will be carried out.

Eligibility criteria:
inclusion criteria: * patients \> 18 years * patients with primary liver disease or liver metastases * patients undergoing liver resection exclusion criteria: * presence of human immunodeficiency virus (hiv) infection * presence of human t leukemia virus (htlv) infection * taking immunosuppressive drugs in the 6 months prior to surgery * a person deprived of liberty by judicial or administrative decision

Keywords: biomarkers
effect of vitamin d supplementation on infliximab response in patients with crohn's disease

Conditions: Crohn Disease; Vitamin D Deficiency; Vitamin D Supplement

Summary: background: it remains uncertain whether vitd3 supplementation is beneficial for remission of crohn's disease (cd). the influence of vitd3 supplementation on infliximab (ifx) efficacy was retrospectively analyzed in chinese cd patients. methods: patients with moderate-to-severe cd, who were bio-naïve and prescribed with ifx treatment for at least 54 weeks were recorded. vitd3 supplementation was defined as patients additionally took oral vitd3 (125 iu/d) within 3 days after the first infusion and persisted in the whole follow-up period. disease activity was assessed using harvey-bradshaw index (hbi). serum cytokine profiles were quantitatively analyzed in a subset of all patients at baseline and 54-week after intervention.


Eligibility criteria:
inclusion criteria: * moderate-to-severe cd * treated with infliximab * bio-naïve at the time of diagnosis exclusion criteria: * had recent supplementation of vitd3 * had prior or concomitant use of other biologic agent, glucocorticoid and/or immunomodulators at the time of enrollment * pregnant * had cognitive/developmental disorders that affected their ability to complete the study procedures * had medical illness or therapies potentially affecting bone, nutrition or growth status
efficacy of vortioxetine (lu aa21004) in the prevention of relapse of major depressive episodes

Conditions: Major Depressive Disorder

Summary: this study will evaluate the efficacy of vortioxetine in the prevention of relapse of major depressive episodes in patients who responded to open-label treatment with vortioxetine.


Eligibility criteria:
inclusion criteria: * major depressive episode (mde) as the primary diagnosis according to dsm-iv tr criteria * at least one other mde before the current one * moderate to severe depression exclusion criteria: * any current psychiatric disorder other than major depressive disorder (mdd) as defined in the dsm-iv tr * any substance disorder within the previous 6 months * female patients of childbearing potential who are not using effective contraception * use of any psychoactive medication 2 weeks prior to screening and during the study randomisation criteria: patients in remission (madrs total score \<=10) at both week 10 and week 12 other protocol-defined inclusion and exclusion criteria may apply.

Keywords: relapse prevention antidepressants placebo-controlled double-blind multicentre study
comparison of two different doses of vitamin d in preterm infants

Conditions: Osteopenia of Prematurity

Summary: randomized clinical trial comparing two different doses of vitamin d supplementation in preterm infants

after randomization each group of preterm neonates (28-32) weeks consisting of 40 neonates within 48 hrs of birth baseline ca.phosphorus, alkaline phosphatase and vitamin d level were withdrawn from each neonate then babies started to take oral vitamin d in different doses (400 iu /day in the 1st group and 1000 iu per day in the 2nd group) after they reach 100 cc per kg per day enteral feeding after they complete 40th week gestational age the investigators repeat the labs again ( serum ca, phosphorus,alp and vitamin d and compare the rate of rise in vitamin d and calcium

Eligibility criteria:
inclusion criteria: * preterm infants delivered at a gestational age ≤ 32 weeks * birth weight ≤1500 kg exclusion criteria: * neonates with major congenital anomalies, * maternal condition or medications likely to influence vitamin d or calcium metabolism * neonates not receiving 100 ml/ kg / day of enteral feeds by 14 days of life
conservative treatment of mallet finger injury

Conditions: Conservatively Treated Mallet Finger Injury

Summary: comparing outcomes of individuals treated with kinesiotape and oval 8 versus quick cast for a conservatively managed mallet finger injury. outcomes include dip joint extension lag, patient satisfaction and function via the mhq.


Eligibility criteria:
inclusion criteria: * determined by a physician to require conservative treatment for a mallet finger injury, at least 18 years of age exclusion criteria: * previous injury to the involved digit impacting rom
exercise intervention and dexterity in parkinson

Conditions: Parkinson

Summary: the investigators conducted an intervention based in proprioceptive exercises and balance tasks. the investigators also carried out a brief intervention in manual dexterity. the study hypothesis is that a brief intervention in upper extremities and a exercise program can increase functionality in parkinson.

motor symptoms in parkinson frequently affect upper extremities. this has been associated in previous studies with limitation in the performance of activities of daily living and, consequently, with a decrease in quality of life. the possibility that a brief intervention improves eye-hand dexterity in parkinson's, may be a therapeutic option to improve the performance of activities of daily living. the investigators also conducted an intervention based in proprioceptive exercises and balance tasks to improve functionality.

Eligibility criteria:
inclusion criteria: * subjects diagnosed with parkinson attending to the parkinson association of granada. * subjects who can complete the assessment battery of tests at the beginning and at the end of the study. exclusion criteria: * auditive and visual disturbances. * cognitive problems. * psychiatric pathology. * sensorial disturbances. * traumatic pathology of the hand. * concomitant neurological conditions.

Keywords: parkinson. dexterity. balance. exercises.
extended evening fasting: metabolic health and energy balance

Conditions: Obesity

Summary: this study will compare metabolic and feeding behaviour responses to 4 days of extended evening fasting vs. a control trial

humans have evolved as a diurnal species, internally governed by the circadian system, which dictates our hormone regulation. 'chrononutrition' is a sub-discipline which combines food timing with circadian physiology. the most popular method of time-restricted feeding in the uk is to skip breakfast. however, data from several meta-analysis have shown that skipping breakfast is associated with weight gain and insulin resistance, likely due to eating later into the evening/night and therefore, out of sync with our circadian rhythm. recent research has shown that skipping dinner (evening fasting) has improved markers of cardio-metabolic health in clinical populations, although these are typically from longer-term studies. despite these promising findings, it is not yet known whether these findings are population specific. therefore, the investigators are interested in examining the metabolic response pre and post intervention to see whether these promising findings can translate into a healthy population. furthermore, the investigators will be monitoring subjective appetite, energy intake and expenditure to assess whether there is any short-term adaptation to a specific feeding window.

Eligibility criteria:
inclusion criteria: * non-smokers. * have maintained a stable weight for 6 months (self-reported). * no history of gastric, digestive, cardiovascular or renal disease (self reported). * female specific: must be using a monophasic, low dose combined ocp (containing less than 50μg oestradiol and a synthetic progestin) or females with regular menstrual cycles (self-reported). exclusion criteria: * severe food allergies, dislike or intolerance of study foods or drinks. * currently undergoing a lifestyle intervention (structured diet or exercise) * diagnosis of a condition or currently undergoing treatment therapy known to affect glucose or lipid metabolism (e.g., type-2 diabetes, taking statins), or contraindications to exercise. * use of medication or supplements that may affect hormone concentrations. * excessive alcohol consumption (\>14 units/week). * intensive training schedule (\>10 hours/week). * female specific: currently pregnant or breastfeeding, the use of any hormonal contraception, and the self-reporting of short (\ 35 d), or irregular menstrual cycles.

Keywords: chrononutrition energy balance intermittent fasting appetite hormones
use of whatsapp for communication between consulting physicians and the emergency physicians

Conditions: Consultation

Summary: the aim of this study is to determinate outcomes of whatsapp messenger (a messaging program for smart phones) usage for communication between consulting physicians and the emergency physicians.

effective communication between consulting physicians and the emergency physicians is critical for patients in the emergency department. whatsapp messenger (a messaging program for smart phones), is the most commonly used for communication in at present. whatsapp messenger is the most globally popular messaging application. also, it has been started to be used for communication in healthcare. the aim of this study is to determinate outcomes of whatsapp messenger usage for communication between consulting and the emergency physicians.

Eligibility criteria:
inclusion criteria: * age≥18 years exclusion criteria: * patients who were not known the reason of admission to emergency service * patients who were not determined consulting physicians' arrival duration to emergency department * patients who were not known the outcomes of consultation * patients transferred other hospitals from emergency service * patients who were not determined the time of consultation call

Keywords: emergency physicians consulting physicians whatsapp