Kornimate/medical-research-clean huggingface dataset:
effect of administration of resveratrol on glycemic variability in individuals with type 2 diabetes mellitus

Conditions: Type 2 Diabetes Mellitus

Summary: type 2 diabetes mellitus \[ t2dm \] has quickly become the epidemic of the xxi century and challenging global health . estimates of the world health organization \[ who \] indicate that globally , from 1995 to date has nearly tripled the number of people living with diabetes mellitus \[dm \]. resveratrol has been extensively studied as a regulator of glucose through its antioxidant effects and protecting pancreatic β cells by activation of sirtuin -1 \[ sirt1 \] dependent deacetylase nicotinamide adenine diphosphate \[ nad \]. therefore, it is important to know the effect of resveratrol on the glycemic variability \[gv \] in patients with t2dm who are not in control with metformin monotherapy based.

the objective is to evaluate the effect of administration of resveratrol on gv in individuals with t2dm inadequately controlled on metformin, for which we will conduct a double-blind trial, randomized, placebo control group, each group 11 male and female patients 30-60 years of age with t2dm inadequately controlled with metformin \[2000 mg / day and glycosylated hemoglobin a1c (a1c) ≥% 7\], with body mass index \[bmi\] form 25.0 to 34.9 kg / m2. randomization will determine who will receive the intervention during the 8-week trial \[resveratrol capsules, 500 mg 3 times daily with the first bite of each meal or approved placebo capsules\], both groups also continue with metformin. the clinical findings and laboratory tests include a metabolic profile and biosafety, which will be made at baseline and at 8 weeks. body weight, body fat, bmi and blood pressure will be determined during the initial and final visit, likewise, plasma glucose concentrations every hour recorded over 72 hours by continuous monitoring system outpatient glucose \[macg\] via ipro ™ 2 \[medtronic minimed, northridge\] system, through which the mean amplitude of glucose excursions \[mage\] is calculated and auc glucose, which will serve to assess the gv. adverse events and adherence to treatment will be documented. statistical analysis: mann-whitney u test, wilcoxon and fisher exact test. it is considered with significance at p \<0.05.

Eligibility criteria:
inclusion criteria: * bmi from 25.0-34.9 kg/m2 * diagnosis of t2dm * fasting plasma glucose \>130 and \<250 mg/dl at the time of scrutiny * a1c between 7 and 10% * metformin monotherapy * written informed consent exclusion criteria: * women pregnant or breastfeeding * untreated thyroid disease and/or uncontrolled hypertension \[≥150 systolic and diastolic ≥90\] * consumption of oral agents or other medications or supplements, unlike metformin, with proven properties that modify the behavior of glucose * total cholesterol \>400 mg/dl * triglycerides ≥400 mg/dl * liver enzymes \[alt and ast\] more than twice the normal range * glomerular filtration rate \<60 ml/min \[cockcroft-gault\]

Keywords: resveratrol glycemic variability mage
effect of early mechanical ventilation to severe acute pancreatitis

Conditions: Acute Pancreatitis; Complication of Ventilation Therapy

Summary: acute lung injury (ali) and acute respiratory distress syndrome(ards) represent the most common and earliest organ dysfunction in acute pancreatitis, presenting as dyspnea and intractable hypoxemia, with secondary bilateral pulmonary infiltrates on radiograph. and mechanical ventilation (mv) is the essential intervention to improve oxygenation. when to initiate mv remains uncertain. in this study, we aim to compare the effect of early mv and conventional mv, and we hypothesize that early mv may be a better treatment option.


Eligibility criteria:
inclusion criteria: * diagnosis of pancreatitis:typical pain, increase in serum lipase or amylase, onset of abdominal pain within 72h before admission * the diagnosis criteria of severe acute pancreatitis is according to atlanta criteria revisited in 2012 * the diagnosis of ards meets the criteria of berlin definition exclusion criteria: * chronic respiratory disease as chronic obstructive pulmonary disease (copd), asthma * organic cardiopathy * pregnancy

Keywords: severe acute pancreatitis mechanical ventilation
safety study of bone-marrow derived mesenchymal stromal cells associated with endobronchial valves in emphysema

Conditions: Pulmonary Emphysema

Summary: the combined use of one-way endobronchial valves and bone-marrow derived mesenchymal stromal cells in patients with severe pulmonary emphysema is safe and will contribute to increase quality of life.

in addition to testing the safety of one-way endobronchial valves combined with bone-marrow derived mesenchymal stromal cells, the study will determine the systemic inflammatory potential of cell therapy measured by c-reactive protein levels (crp), erythrocyte sedimentation rate (esr) and complete blood count in peripheral blood. finally, the study will aim at determining if other markers of inflammatory response and remodeling are modulated by this therapy.

Eligibility criteria:
inclusion criteria: * diagnosis of severe heterogeneous emphysema (heterogeneity \> 15%), with heterogeneity defined as the difference between lobes in the percent area covered by parenchymal density greater than -950 hounsfield units. * estimation of collateral ventilation based on fissure with integrity ≥ 75%. * total lung capacity\> 100% predicted. * residual volume\> 150% predicted. * forced expiratory volume at the first minute \<45% predicted. * diffusing capacity of the lungs for carbon monoxide \<45% predicted. * optimal medical treatment. * limitations in daily physical activities. * minimum of 4 months without smoking * having family support. * stage ≥ 2 in modified medical research council dyspnea scale (mmrc). exclusion criteria: * homogenous emphysema. * presence of collateral ventilation. * use of systemic corticosteroids (prednisone\> 20mg/day or equivalent). * pulmonary or extrapulmonary infection. * coronary heart disease and/or severe ventricular dysfunction. * significant renal or liver disease. * immunosuppressive disease. * active smoking. * cancer prognosis with survival \<2 years. * psychosocial problems. * pregnancy.
upar pet/ct for staging advanced and localised oral and oropharyngeal cancer

Conditions: Oral Cancer; Oropharyngeal Cancer; Neoplasms; Head and Neck Neoplasms; Cancer of Mouth; Neoplasms by Site

Summary: upar pet/ct for staging advanced and localised oral and oropharyngeal cancer

to compare the diagnostic value of upar-pet/ct for prognostication compared to the current imaging options (ct, mri and ultrasound) by observer-blinded readings. the reference that will be used as "gold standard" is the pathological examination of the surgically removed tissues. the new imaging modality (upar-pet/ct) will be used in two separate groups of patients with head and neck cancer: study i: patients with oral cancer without clinical evidence of spread (oscc in stage cn0) study ii: patients with metastatic oral cancer (oscc in stage cn +) and patients with metastatic oropharyngeal cancer (opscc in stage cn +).

Eligibility criteria:
inclusion criteria: * able to understand patient information and to give informed consent * not previously irradiated or operated on neck * operable disease study i oscc cn0 verified histologically by pathologic examination of biopsy study ii oscc or opscc n + verified histologically by pathologic examination of biopsy exclusion criteria: * pregnancy * patients who are candidates for curative intentional radiation * patients who have had surgery or radiation therapy to the neck as this may alter the lymph drainage. * other diseases assessed by the investigator as basis for exclusion. * age under 18 or over 85 years * obesity\> 140 kg * allergy to 68ga-nota-ae105

Keywords: uroplasminogen plasminogen activator receptor oropharyngeal cancer oral cancer positron emission tomography
niacin skin flush response in patients with schizophrenia

Conditions: Schizophrenia

Summary: patients with schizophrenia have abnormal skin flush response to niacin, but the niacin skin test accuracy is not well studied in these patients. the study evaluated the niacin skin test accuracy in adult hospitalized schizophrenia patients and their first degree relatives, bipolar disorder patients, and healthy controls.


Eligibility criteria:
inclusion criteria: * diagnosis of schizophrenia patients and bipolar disorder patients diagnosed according to the diagnostic and statistical manual of mental disorders version iv criteria * normal healthy subjects without a psychiatric history * first degree relatives of schizophrenic patients exclusion criteria: * dermatological lesions, asthma or allergic disease, diabetes, chronic hypertension, vasculitis, substance use disorders (except cigarette smoking), or pregnancy * taking any oral medication that could affect the metabolism of prostaglandins such as nonsteroidal anti-inflammatory drugs or corticosteroids
p. falciparum infection dynamics and transmission to inform elimination (indie-1a)

Conditions: Malaria

Summary: in the current randomized trial, the investigators will test the ability of two experimental approaches to malaria infection management to reduce malaria transmission potential. compounds in saponé, burkina faso, will be randomized to 1 of 3 study arms: arm 1 - current standard of care with passively monitored malaria infections; arm 2 - standard of care plus enhanced community case management (ccm), comprising active weekly screening for fever, and detection and treatment of infections in fever positive individuals using conventional rapid diagnostic tests (rdts); or arm 3 - standard of care and enhanced ccm, plus monthly screening and treatment (msat) using rdts. the study will be conducted over approximately 18 months covering two high transmission seasons and the intervening dry season


Eligibility criteria:
inclusion criteria: 1. participants should be permanent residents of the compound 2. participants should be willing to participate in repeated assessments of health and infection status and willing to donate a maximum of 37ml of blood (children \<10 years of age) or 52ml of blood (older individuals) during an 18-month period exclusion criteria: 1. any (chronic) illness that would affect with study participation 2. pre-existing severe chronic health conditions 3. current participation in malaria vaccine trials or participation in such trials in the last 2 years 4. history of intolerance to artemether-lumefantrine

Keywords: falciparum gametocyte elimination anopheles transmission diagnostic
bilateral dispensing clinical trial of stenfilcon a against etafilcon a for astigmatism

Conditions: Astigmatism

Summary: bilateral dispensing clinical trial of stenfilcon a against etafilcon a for astigmatism.

coopervision is evaluating the clinical performance of an fda cleared silicone-hydrogel lens material stenfilcon a (test) compared to etafilcon a for astigmatism lens (control) when worn on a daily wear basis over one (1) week in a randomized, bilateral, cross-over, dispensing study.

Eligibility criteria:
inclusion criteria: * is at least 17 years of age for canada and 18 years of age for the usa and has full legal capacity to volunteer; * has read and signed an information consent letter; * is willing and able to follow instructions and maintain the appointment schedule; * is an adapted soft contact lens wearer; * requires a spherical contact lens prescription between -1.00 to -6.00 inclusive in each eye * has spectacle astigmatism: -0.50 to -1.50d (diopter) cylinder (axis: 90±20, 180±20 in both eyes); * willing to wear contact lens in both eyes for at least 8 hours per day, 7 days per week; * has manifest refraction visual acuities (va) equal to or better than logmar equivalent of 20/25 in each eye; * to be eligible for lens dispensing, the subject must have va of logmar equivalent of 20/30 or better in each eye with the study lenses and the investigator must judge the fit as acceptable. exclusion criteria: * is participating in any concurrent clinical or research study; * has any known active\* ocular disease and/or infection; * has a systemic condition that in the opinion of the investigator may affect a study outcome variable; * is using any systemic or topical medications that in the opinion of the investigator may affect a study outcome variable; * has known sensitivity to the diagnostic pharmaceuticals to be used in the study; * is pregnant, lactating (by verbal confirmation at the screening visit); * is aphakic; * has undergone refractive error surgery
psychotherapy to patients with primary breast cancer - psycho-social and survival outcome from a randomised trial

Conditions: Breast Cancer

Summary: the purpose of this study is to determine whether an intervention to breast cancer patients including psycho-education and group psychotherapy can enhance quality of life and survival.

purpose: this randomized study included patients diagnosed with breast cancer who participated in an intervention including education and group psychotherapy lasting 10 weeks after surgery. the purpose of the study was to enhance quality of life, coping and social relations and to support the women when going through treatment. patients and methods: we randomly assigned 210 patients with primary breast cancer to a control or an intervention group. patients in the intervention group were offered 2 weekly 6-hour sessions of psycho-education and eight weekly 2-hour sessions of group psychotherapy. participants and nonparticipants were followed up for qol, coping and social relations after one, six and twelve months post intervention and on vital status 5 years after surgical treatment.

Eligibility criteria:
inclusion criteria: * eligible patients were 18-70 years of age with stage i-iiia primary breast cancer exclusion criteria: * distant metastasis * not speaking or understanding danish * over 71 years * other life-threatening diseases * brain-damaged

Keywords: quality of life coping social relations survival psychotherapy
the preform study: rotational fractional resection for submental contouring

Conditions: Skin Laxity; Lipodystrophy

Summary: this study will evaluate the safety and efficacy of rotational fractional resection (rfr) to improve neck contouring. rotational fractional resection is used to remove loose skin and fat.

this is a prospective, single-center, single-arm (non-randomized), interventional cohort, non-significant risk (nsr) study designed to investigate the efficacy and safety of rotational fractional resection (skin resection and focal lipectomy) in patients with moderate to severe submental skin laxity. the total duration of study participation for each subject is approximately up to 4 months for each subject from the screening visit to the exit visit. the follow-up period will be approximately 3 months after the procedure. eligible subjects will complete a total of 11 study visits: screening, procedure, and follow-up visits at 1, 4, 7, 14, 21, 30, 45, 60, and 90 days post-procedure.

Eligibility criteria:
inclusion criteria: * healthy male or female * at least 30 years old * moderate to severe submental laxity * up to moderate submental lipodystrophy * agree to maintain weight (±5%) for the duration of the study exclusion criteria: * previous intervention to treat submental fat or skin laxity * use of aspirin, ibuprofen, naproxen, or vitamin e within 14 days of the procedure * severe acne, cystic acne or acne scars on neck * trauma of chin or neck area * skin infection or rash on neck * psoriasis, hyperpigmentation, eczema, rosacea or vitiligo * history of scarring * body mass index (bmi) \>30 * clinically significant bleeding disorder * anemia, kidney disease, or liver disease

Keywords: submental laxity lipodystrophy
intubation during adult intubation

Conditions: Cardiac Arrest

Summary: the objective of this study is to compared effectiveness of intubation using etview vivasight sl and standard tracheal tube during resuscitation performed by a ems-paramedics.


Eligibility criteria:
inclusion criteria: * give voluntary consent to participate in the study * minimum 1 year of work experience in emergency medicine * experienced emergency medical personnel (physicians, nurses, paramedics) exclusion criteria: * not meet the above criteria * wrist or low back diseases

Keywords: endotracheal intubation
prevention of post sexual assault stress

Conditions: Drug Use; Drug Abuse; Posttraumatic Stress Disorder

Summary: the purpose of this study is to evaluate whether a brief intervention in video format, that includes education about reactions to assault and modeling of adaptive coping strategies, designed to reduce post assault drug use or abuse and ptsd and shown to recent victims of sexual assault at the time of receipt of post assault medical care is associated with better post-assault outcomes as compared to a comparable length video that includes pleasant imagery and relaxation instruction or standard care.

post assault outcomes include coping behaviors and ptsd symptoms.

Eligibility criteria:
inclusion criteria: * seeking medical care after recent sexual assault exclusion criteria: * active psychosis active suicidality cognitive impairment non-english speaking severe injury

Keywords: rape secondary prevention intervention
non-endoscopic brushing of the esophagus using a non-endoscopic inflatable balloon of the esophagus in screening for barrett esophagus

Conditions: Barrett Esophagus

Summary: this pilot clinical trial studies non-endoscopic brushing of the esophagus using a non-endoscopic inflatable balloon for the esophagus in screening for barrett esophagus, a condition where the lining of the esophagus has changed or been replaced with abnormal cells that may lead to cancer. the non-endoscopic inflatable balloon for the esophagus is a capsule balloon that brushes against the walls of the esophagus to collect esophageal samples. non-endoscopic brushing of the esophagus using a non-endoscopic inflatable balloon for the esophagus may help doctors find barrett esophagus sooner, when it may be easier to treat.

primary objectives: i. to determine acceptability of non-endoscopic balloon brushing of esophagus. ii. to demonstrate successful performance of the methylation of vimentin (mvim) assay in balloon brushings from subjects with and without barrett's esophagus (be). iii. to examine molecular and histological factors that might lead to false negative and false positive mvim assays in be screening. iv. to assay additional methylated deoxyribonucleic acid (dna) biomarkers that might improve the sensitivity and specificity of mvim in balloon brushings. outline: patients undergo non-endoscopic brushing of the esophagus using a non-endoscopic inflatable balloon for the esophagus over 30-60 minutes followed by a standard esophagogastroduodenoscopy (egd). after completion of study, patients with serious adverse events are followed up until resolution, stabilization, or until it has been determined that the study treatment or participation is not the cause.

Eligibility criteria:
inclusion criteria: * patients are undergoing clinically indicated esophagogastroduodenoscopy (egd) * patients can provide informed consent * patients have no known coagulopathy and no known history of esophageal varices exclusion criteria: * patients are not undergoing clinically indicated egd * patients have known coagulopathies or history of esophageal varices * patients do not have the ability to give informed consent

Keywords: barrett cancer screening
brazilian green propolis extract (epp-af) as an adjunct treatment for hospitalized covid-19 patients (beecovid2)

Conditions: Covid19; Inflammation

Summary: severe acute respiratory syndrome coronavirus 2 (sars-cov-2) promotes challenging immune and inflammatory phenomena. though various therapeutic possibilities have been tested against coronavirus disease 2019 (covid-19), the most adequate treatment has not yet been established. among candidate adjunct treatment options, propolis, produced by honey bees from bioactive plant exudates, has shown potential against viral targets and has demonstrated immunoregulatory properties.

to evaluate the efficacy and safety of oral propolis as an adjunct treatment for sars-cov-2 infection, we designed a randomized, double-blind, placebo-controlled trial (bee-covid2) (the use of brazilian green propolis extract (epp-af®) in patients affected by covid-19).

Eligibility criteria:
inclusion criteria: * older than 18 years; * diagnosis of coronavirus infection confirmed by polymerase chain reaction - reverse transcriptase testing; * symptoms started within 14 days of the randomization date exclusion criteria: * pregnant or lactating women; * known hypersensitivity to propolis; * propolis use less than 30 days from the randomization date; * active cancer; * human immunodeficiency virus carriers; * patients undergoing transplantation of solid organs or bone marrow or who were using immunosuppressive medications; * bacterial infection at randomization, sepsis or septic shock related to bacterial infection at randomization; * impossibility of using the medication orally or by nasoenteral tube; * known hepatic failure or advanced heart failure (new york heart association \[nyha\] class iii or iv). * end stage renal disease (esrd).

Keywords: propolis covid19 anti-inflammatory agents immunoregulation
isolated growth hormone deficiency and amennorrhea

Conditions: Growth Hormone Deficiency

Summary: this is a case report of a 14-year old female with no menstruation history.

this is a case report of a 14-year-old with a chief complaint of inability to menstruate. lab tests were done.

Eligibility criteria:
inclusion criteria: * a single female participant with amenorrhea exclusion criteria: * the study only included the above subject

Keywords: isolated growth hormone deficiency amenorrhea