Kornimate/medical-research-clean huggingface dataset:
assessment of complementary feeding of canadian infants

Conditions: Generation of Reactive Oxygen Species; Intestinal Inflammation

Summary: with the recent recommendation from health canada to extend exclusive breast-feeding to 6 months of age there has arisen concern about what is the best solid food to introduce at that time. traditionally solids were introduced in canada at 4-6 months and usually iron-fortified rice cereal was the first food of choice. new recommendations from health canada include meat as a potential first food as well as other iron fortified foods. this has lead to uncertainty of both public health officials and parents about the optimal introduction and choice of solids after exclusive breastfeeding. in addition to meeting iron needs with the first solid food choice, the investigators are concerned about the possible generation of reactive oxygen species (ros) in the gut of the infant fed traditional iron fortified cereals. infant cereals are fortified at 25-30 mg iron per 100 g dry-weight. absorption of the non-heme electrolytic iron ranges from 5-10% so that most of the residual iron enters the colon. normally excess iron is sequestered by a variety of mechanisms in the body, but there is no such system for the sequestering of iron in the gut lumen. the investigators have shown that providing iron supplements to adults where the majority of the iron is unabsorbed passes through the digestive tract can lead to the generation of ros in the colon. these effects are seen in adults receiving 1 mg/kg/day supplemental iron. by 5-6 months of age infants consuming iron fortified cereals will receive the same dose and are likely producing ros in their digestive tract. this may cause inflammation and make infants more susceptible to disease. the investigators think that meats and infant cereals with phenolic antioxidants available from fruits will likely reduce the generation of ros in vivo. therefore the investigators wish to determine if traditional and newly recommended first foods are safe from a free radical and inflammatory perspective. hypotheses: 1. consumption of infant cereals with iron will increase ros generation in the gut 2. consumption of infant cereals with iron and fruit will decrease ros in the gut 3. consumption of meat will not generate ros 4. consumption of iron fortified cereals or meat will maintain iron status during infancy


Eligibility criteria:
inclusion criteria: * full term infant * birth weight more than 2500g * absence of any medical conditions exclusion criteria: * consumption of more than 200ml formula

Keywords: iron intestinal inflammation ros
pallidal stimulation and gilles de la tourette syndrome

Conditions: Gilles de la Tourette Syndrome

Summary: the aim of this study is to evaluate the efficacy and safety of bilateral pallidal stimulation in patients with a severe form of gilles de la tourette syndrome.

it acts of a randomized study, in parallel, double group blind, multi-centric relating to 14 patients. the interest of this multicentric study, which will be carried out in centers specialized in the field of major cerebral stimulation with for each one a multidisciplinary team, is to carry out a homogeneous protocol which should make it possible to give a clear response in term of effectiveness for this treatment in this pathology. the evaluation will be: 1. neurological (ygtss, video scale of the tics); 2. psychiatric, with in particular of the specific psychopathological evaluations centered on mood; 3. neuropsychological, centered on impulsiveness; 4. functional calculus evaluating total operation and the social adaptation; 5. neurophysiological (recording of the neuronal activities). calculations of the number of subjects necessary showed, by laying down the principal objective at an improvement of at least 60 % of the score of the ygtss under treatment, which 14 subjects will make it possible to show a significant difference with the procedure placebo. study in tomography by emission of positrons (mtoe) carried out on 8 of the 14 operated patients having had at least 3 months of stimulation, in comparison on 8 pilot subjects (paired for the sex and the age), should make it possible to determine, at the time of the improvement of the driving symptoms, modifications of cerebral activation induced by the high frequency stimulation of gpi among patients. the association of this study to the comparison of the improvement of the neurological symptoms with the precise localization of the therapeutic stud of the electrode reformatted on the post-operative tdm (8), carried out for all the patients, should make it possible to specify the anatomy-physiological bases to specify the anatomy-physiological bases of the mgt the duration of the study will be 14 month for each patient, that is to say one 2 months preoperative period intended for inclusion; one 3 months post-operative period without stimulation; one period randomized with stimulation either "one" (3 months), or "off" (3 months), then an open study for all the patients with stimulation "one" for one 6 months duration. it is envisaged to include 14 patients reached of the mgt (of which 8 will take part in study mtoe) and 8 subjects controls for study mtoe is 22 subjects. an observational follow-up at 30 and 48 months is added.

Eligibility criteria:
inclusion criteria: * severe form of gts * age 18 to 60 years * failure of medical treatment (including neuroleptics) exclusion criteria: * major depression * psychotic symptoms * severe personality disorder

Keywords: gilles de la tourette syndrome deep brain stimulation globus pallidus
does dexamethasone administration improve recovery in patients undergoing minimally invasive sacrocolpopexy?

Conditions: Quality of Life; Pelvic Organ Prolapse; Prolapses, Vaginal Vault

Summary: the primary aim is to evaluate whether standard administration of dexamethasone at the time of general anesthesia induction at the time of minimally invasive sacrocolpopexy (misc) would result in improved quality of recovery (qor).

there has been a public outcry regarding the continuing rise of health care expenditures. in 1997, the estimated costs of surgery for pelvic organ prolapse (pop) were $ 100.1 million. it is important to identify interventions that would improve the qor in this patient population and to speed-up postoperative recovery. as most of these surgeries are performed in an outpatient manner as a 23 hour observation, improved recovery may also speed discharge and free-up valuable hospital resources. patients will receive either dexamethasone or placebo ( normal saline) at the time of induction of general anesthesia. qor questionnaires, pain scale and postoperative nausea and vomiting scale (ponv).

Eligibility criteria:
inclusion criteria: 1. women over the age of 18 2. women scheduled for minimally invasive sacrocolpopexy with or without concomitant anti-incontinence procedure and with or without concomitant hysterectomy 3. american society of anesthesiologists (asa) class 1-2 exclusion criteria: 1. daily use of steroids, antiemetics in the month prior to surgery 2. chronic pain requiring daily opioid treatment 3. history of allergy/intolerance to dexamethasone 4. asa class 3 5. numerical pain score (nps) of more than 4 at baseline 6. renal/liver disease 7. diabetes mellitus 8. pregnancy 9. inability to answer questionnaires 10. any systemic infections 11. immuno compromised status

Keywords: quality of recovery minimally invasive sacrocolpopexy dexamethasone
the efficacy of 3% kanuka oil versus 1% hydrocortisone cream in patients with atopic dermatitis

Conditions: Dermatitis, Atopic; Pruritus

Summary: atopic dermatitis is a common disease affecting millions worldwide. a common associated symptom in this population is pruritus. we seek to investigate the use of an natural, over-the-counter cosmeceutical to help this population

there are many treatment options available for atopic dermatitis yet many patients still suffer from the underlying symptomatology. it is important to explore other treatment alternatives to help this population.

Eligibility criteria:
inclusion criteria: * age greater than 12 years, diagnosis of atopic dermatitis for longer than 2 years, investigator's static global assessment score of either 2 or 3, and initial worst itch numerical rating scale (wi-nrs) for itch greater than 4. exclusion criteria: * the use of topical or systemic corticosteroids within 28 days of entering the study, the use of any other non-emollient therapy within 28 days of entering the study,nursing, and pregnancy
efficacy study of acupoint sticking in summer to treat asthma

Conditions: Asthma

Summary: the purpose of this study is to assess whether acupoint sticking in treating winter diseases in summer is effective in the treatment of chronic asthma.

asthma is a common chronic disease with an estimated 300 million worldwide. treating winter diseases in summer of traditional chinese medicine treatment of asthma has a long history. but there are less related clinical trials. the purpose of this study is to assess whether acupoint sticking in treating winter diseases in summer is effective in the treatment of chronic asthma. after screening period, participants will undergo a physical examination, lung function, blood and induced sputum collection while being randomly assigned to one of the following 2 groups for 6 weeks during summer dog days of treatment: group a will receive acupoint sticking treatment of chinese herbal medicine and magnetic stickers once every two days； group b will receive acupoint sticking treatment of chinese herbal medicine and sham magnetic stickers once every two days. questionnaires to assess asthma control and quality of life will be completed. a physical examination, blood collection, and induced sputum collection will occur at selected visits.

Eligibility criteria:
inclusion criteria: * patients diagnosed with mild-to-moderate remission phase of asthma * patients who have given written informed consent exclusion criteria: * participation in another clinical trial 1 month prior to study entry * participation received acupoint sticking of winter disease cured in summer * use of corticosteroids 4 weeks prior to study entry * patients who are allergic to therapeutic medicine * female patients in lactation period, pregnancy or planning to get pregnant during the trial * patients with severe primary diseases such as cancer, cardiovascular system, digestive system, kidney and hematopoietic system diseases * patients with mental illness, acrasia
a 2-year study of eyp-1901 in subjects with wet age related macular degeneration (wamd) (lucia) primary efficacy will be determined at week 56

Conditions: Wet Age Related Macular Degeneration; wAMD

Summary: this is a phase 3 randomized, double -masked study comparing the efficacy of eyp-1901 against aflibercept.


Eligibility criteria:
inclusion criteria: * previously treated or treatment naïve patients with a documented diagnosis of wamd in the study eye, with onset of disease that began at any time prior to the screening visit. * best corrected visual acuity (bcva) by early treatment diabetic retinopathy study (etdrs) letter score between 78 to 35 letters (approximately 20/32 to 20/200 snellen equivalent) in the study eye at the screening visit and on baseline (day 1). * for previously-treated subjects, must have been treated with at least 2 anti-vegf ivt injections (i.e., aflibercept 2 mg, aflibercept 8 mg, bevacizumab, ranibizumab, or faricimab) in the previous 6 months for wamd per standard of care in the study eye prior to the screening visit. exclusion criteria: * subfoveal fibrosis, atrophy, or scarring in the center subfield. * bcva using etdrs charts \<20 letters (20/400 snellen equivalent) in the fellow eye.

Keywords: wet age-related macular degeneration tyrosine kinase inhibitor eyp-1901 eyepoint
impact of a pain neuroscience education program on primary students with and without intellectual disabilities

Conditions: Chronic Pain (back / Neck)

Summary: this observational study evaluates the impact of a pain neuroscience education (pne) program on primary school students in extremadura, spain. the study examines satisfaction levels and knowledge acquisition regarding pain neuroscience among students with and without intellectual disabilities. conducted across both rural and urban educational centers, as well as special and regular education schools, this study aims to identify the effectiveness of pne in enhancing pain-related knowledge and addressing sustainable development goals (sdgs) awareness. additionally, the program includes interactive educational activities tailored for accessibility, using resources such as easy-to-read questionnaires and hands-on models, to support inclusive health education. data collection involves pre- and post-intervention questionnaires to assess satisfaction and knowledge gains, with statistical analysis exploring differences between demographic and school-type groups.


Eligibility criteria:
inclusion criteria: * students enrolled in the fifth or sixth grade of primary education in schools within the autonomous community of extremadura. * students who regularly attend academic activities and complete the educational intervention. exclusion criteria: * students who do not attend school regularly or who are not expected to complete the intervention. * students with severe cognitive or behavioral impairments that may interfere with participation in the educational activities.

Keywords: pain management health education students neuroscience
randomized study of human parathyroid hormone in middle-aged men with idiopathic osteoporosis

Conditions: Osteoporosis

Summary: objectives: i. determine the effect of human parathyroid hormone (1-34) on bone mass in middle-aged men with idiopathic osteoporosis.

protocol outline: this is a randomized, double blind, placebo controlled study. all patients self-administer daily subcutaneous injections of human parathyroid hormone (1-34) or placebo for a period of 2.5 years. patients are followed regularly for unacceptable toxicities. completion date provided represents the completion date of the grant per oopd records

Eligibility criteria:
protocol entry criteria: --disease characteristics-- osteoporosis as defined by: bone mineral density at the lumbar spine or femoral neck that is 2.5 standard deviations below peak bone mass reference value (t score less than -2.5) no family history of male osteoporosis no other metabolic bone disease --prior/concurrent therapy-- endocrine therapy: * no concurrent glucocorticoid therapy * no prior steroid use surgery: no prior gastrointestinal tract surgery other: no prior or concurrent anticonvulsant therapy --patient characteristics-- hematopoietic: normal cbc hepatic: normal liver function renal: normal renal function other: * normal thyroid function * normal adrenal function * normal gonadal status * no myeloma or other malignancy * no alcoholism, hypercortisolism or diabetes mellitus * no gastrointestinal tract disease or disorder associated with malabsorption

Keywords: disease-related problem/condition osteoporosis rare disease
the relationship between cmv* reactivation and anti-cytokine treatment in critical covid-19 patients

Conditions: COVID-19, Cytomegalovirus (CMV), Tocilizumab, Anakinra, Mortality

Summary: the risk of secondary infection is high in critical patients hospitalized with the diagnosis of covid-19. immunosuppressive treatments are commonly used in critical covid-19 patients, and immune dysfunction and cmv reactivation can be unnoticed in these patients.

the records of critical patients were reviewed retrospectively. whether these patients used tocilizumab and/or anakinra and their relationship with cmv reactivation were examined. furthermore, the relationship between cmv reactivation and mortality and anti-cytokine treatment in patients was also examined. a total of 167 critical covid-19 patients were included in the study, of which 38 (22.7%) were found to be cmv dna positive. cmv positivity in patients treated with anti-cytokines (31.11%) was found to be significantly higher than in patients who were not treated with it (16.88%) (p:0.033). there was no significant difference in viral load levels (p:0.513). furthermore, it was determined that anti-cytokine treatment significantly decreased mortality (p: 0.003) and that there was no significant relationship between cmv reactivation and mortality (p: 0.399). even though cmv reactivation was high in critical covid-19 patients who received anti-cytokine treatment, positive developments in morbidity and mortality were observed with early diagnosis and effective treatment.

Eligibility criteria:
inclusion criteria: * critically ill patients over the age of 18 diagnosed with covid-19 and patients followed in the intensive care unit. exclusion criteria: * patients under the age of 18 with a mild/moderate course of covid-19, * cmv pcr positive before anti-cytokine treatment, * patients who underwent hematopoietic stem cell transplantation
quad resection (hot snare vs cold snare vs hot emr vs cold emr)

Conditions: Colon Cancer; Colon Polyp; Colon Adenoma

Summary: the study will compare the use of cold snare, hot snare, cold emr, and hot emr for polyp resection. although previous studies have compared two of the potential resection methods, no previous study has evaluated all four of the resection methods.

the optimal method for removal of polyps 6-9 and 10-15 mm in size is not established. in this study, we propose to evaluate four different treatments for polyps (sized 6mm-15mm). the four treatments are cold snaring without injection, hot snaring without injection, cold emr, and hot emr. this study aims to help to establish the optimal resection technique for 6-9 and 10-15 mm polyps.

Eligibility criteria:
inclusion criteria: * aged 40 years or older * ability to provide informed consent exclusion criteria: * subjects with a history of inflammatory bowel disease * lesions less than 6mm or greater than 15mm in largest dimension

Keywords: polyp resection cold snare hot snare cold endoscopic mucosal resection (emr) hot endoscopic mucosal resection (emr) colonoscopy
evaluation of endoscopic ultrasound shear wave elastography (eus-swe) for the diagnosis of pancreatic adenocarcinoma.

Conditions: Pancreas Cancer

Summary: to assess the diagnostic accuracy of shear wave elastography (swe) for the diagnosis of pancreatic adenocarcinoma.

pancreatic adenocarcinoma (pa) is the most common tumor of the pancreas, representing more than 90% of all solid pancreatic neoplasia and 55% -73% of solid pancreatic masses. given its poor prognosis and the major therapeutic consequences, the discrimination between pa and other pancreatic solid lesions is mandatory. endoscopic ultrasound (eus) is admitted as the most sensitive imaging procedure for the detection and characterization of pancreatic tumors. based on only endosonographic features, it remains difficult to differentiate pa from other solid masses, the specificity (spe) and accuracy of eus for the diagnosis of pancreatic tumor malignancy range from 53-69% and 72-83%, respectively. over the last 15 years, endoscopic ultrasound fine needle aspiration (eus-fna) or more recently fine needle biopsy (eus-fnb) has demonstrated its efficiency for tissue sampling and pathologic diagnosis of pa. complementary techniques have been developed to increase the diagnostic performance of eus. eus-elastography (eus-e) is another eus image enhancement technique, which rational based on the difference in elasticity between the tissues. there are two types of elastographies: strain elastography (se) and shear wave elastography (swe). several studies have demonstrated the utility of ultrasound swe (us-swe) for the differential diagnosis of lesions of the breast, thyroid, prostate and for detection of pancreatic fibrosis and chronic pancreatitis. however, to date, there is no data about the performance of eus-swe for the differential diagnosis of pancreatic solid lesions.

Eligibility criteria:
inclusion criteria: * patient over 18 years of age * patient with a solid pancreatic mass of indeterminate origin exclusion criteria: * patient with asa score 4 or 5 * patient with contraindication to sonovue injection * protected patient : major under guardianship, tutorship or other legal protection, deprived of liberty by judicial or administrative decision
voyage: real-world impact of the multi-target stool dna test on crc screening and mortality

Conditions: Colon Cancer

Summary: the purpose of this study is to gather information about the long term health of people who have been prescribed the cologuard test, which is used for colorectal cancer (crc) screening.

participates will be consented for prospective follow-up for health outcomes, which will be ascertained through periodic contacts. participants will complete a baseline health questionnaire survey (t0) and a 1-year follow-up questionnaire survey (t1), allow access to medical records, when available, and allow future contacts for additional surveys.

Eligibility criteria:
inclusion criteria: * resident of the united states * age 18 years or older * able to provide informed consent * able to complete surveys in english or spanish * valid order for cologuard screening exclusion criteria: * n/a
levosimendan administration in neonates with transposition of the great arteries

Conditions: Low Cardiac Output Syndrome

Summary: calcium sensitizer drugs such as levosimendan may exert anti-ischemic effect in addition to positive inotropic and anti-stunning effects mediated by the opening of atp-sensitive potassium (katp) channels. the aim of the study is to test the myocardial protection effect of peri-operative iv infusion of levosimendan in a cohort of neonates affected by transposition of the great arteries undergoing surgical correction by arterial switch.

function of the myocardium of neonates with congenital heart disease may be affected by several factors in post operative phase: congenital insufficiency, cardiopulmonary bypass low perfusion, ischemima during the cross-clamp phase, low cardiac output syndrome, systemic inflammation. furthermore, neonates have immature molecular mechanisms leading to calcium utilization inside myocytes. calcium sensitizer drugs such as levosimendan may exert anti-ischemic effect in addition to positive inotropic and anti-stunning effects mediated by the opening of atp-sensitive potassium (katp) channels. the aim of the study is to test the inodilator and myocardial protection effect of peri-operative iv infusion of 0.1 mcg/kg/min levosimendan (without previuos bolus) in a cohort of neonates affected by transposition of the great arteries undergoing surgical correction by arterial switch.

Eligibility criteria:
inclusion criteria: * neonates affected by transposition of the great arteries scheduled to elective surgery exclusion criteria: * neonates affected by transposition of the great arteries who are not scheduled to elective surgery (urgent procedures, patients older than 30 days)

Keywords: levosimendan pediatric cardiac surgery low cardiac output syndrome transposition of the great arteries