Kornimate/medical-research-clean huggingface dataset:
the change in carotid intima-media thickness after laparoscopic sleeve gastrectomy

Conditions: Weight Loss; Reduce the Risk of Cardiac Disease; Carotis Intima-media Thickness

Summary: the aim of this study was to compare carotid intima-media thicknesses in laparoscopic sleeve gastrectomy patients preoperatively and at the end of the first postoperative year.

obesity is not only a disease in itself, but also predisposes to many other diseases. cardiac diseases are one of the systems that obesity predisposes to. obesity has been found to increase the risk of cardiac disease by increasing carotid intima-media thickness in patients with obesity. surgery is known to be the most effective treatment for obesity and laparoscopic sleeve gastrectomy is the most common bariatric surgery procedure. laparoscopic sleeve gastrectomy may reduce the risk of cardiac disease by reducing carotid intima-media thickness in patients with obesity through effective weight loss.

Eligibility criteria:
inclusion criteria: * 18-65 years old, * bmi \> 35 kg/m2 * laparoscopic sleeve gastrectomy will be performed * patients with cardiac disease exclusion criteria: * patients without cardiac disease * patients who performed other bariatric surgery procedures

Keywords: carotis intima-media thickness laparoscopic sleeve gastrectomy
simplified severe sepsis protocol in zambia

Conditions: Sepsis; Severe Sepsis

Summary: this study is a randomized control trial assessing the impact of a simple evidence-based protocol for the treatment severe sepsis in zambia. the intervention protocol consists of a scheduled fluid regimen, early blood culture and antibiotics, and dopamine and blood transfusion when necessary. it is hypothesized that the protocol will significantly decrease in-hospital mortality in patients with severe sepsis.

in recent years, evidence-based protocols of bundled therapies have improved survival of severe sepsis in developed countries. however, in sub-saharan africa, simple therapies such as iv fluids and early antibiotics are frequently under-utilized. furthermore, although tuberculosis is a common cause of severe sepsis in the region, accurate and timely diagnosis of tuberculosis-associated severe sepsis remains elusive. the aims of this study are (1) to assess the impact on survival of a simple evidence-based protocol for severe sepsis, (2) to evaluate the cost of implementation for a simplified severe sepsis protocol (3) to develop a clinical diagnostic score for identifying tuberculosis in hiv positive patients with severe sepsis (4) to assess the performance of the xpert tb/rif rapid pcr system for diagnosing tuberculosis in hiv positive patients with severe sepsis.

Eligibility criteria:
inclusion criteria: * age 18 or older * suspected infection * 2 or more of sirs criteria: * heart rate \>90/min * respiratory rate \>20/min * temperature \>= 38° c or \<= 36° c * white blood count \> 12,000 or \< 4,000/µl * 1 or more of the following signs of end-organ dysfunction * systolic blood pressure \< 90 mm hg * mean arterial blood pressure (map) \< 65 mm hg * confusion/altered mentation * urine output \< 0.5 ml/kg/hr * creatinine increase \> 0.5 mg/dl * creatinine \> 0.5 mg/dl above upper limit of normal * platelet \< 100x109/l * respiratory rate \> 40/min * jaundice exclusion criteria: * gi bleed * need for urgent surgery

Keywords: sepsis severe sepsis protocol zambia
predictors of respiratory syncytial virus (rsv) hospitalizations in infants

Conditions: Syncytial Virus Respiratory Infection; RSV Infection; Respiratory Syncytial Virus Infections; RSV Bronchiolitis

Summary: the vrs (respiratory syncytial virus) study group in lyon is a working that aims to understand, predict and prevent the burden of disease caused by human respiratory syncytial virus (rsv) infection in infants. incidence of rsv-associated hospitalization in the first year of life was estimated at 14.5 (95% ci 13.4-15.6) per 1000 births in a cohort study in lyon, france. related direct medical annual costs were estimated for this cohort at 364,269€, mostly attributed to children born during the rsv season (231,959€) and children born premature (108,673€). this study will combine existing hospital specimens and databases to determine the respective role of socio demographic factors, clinical risk factors, level of cord specific antibody at birth, and virus characteristic in the respiratory syncytial virus (rsv) hospitalization outcome in infants. regarding the introduction of a new rsv vaccine and rsv-specific neutralizing antibodies, these data are of prime importance to guide future vaccine policies.

objective: to determine the main predictors of respiratory syncytial virus (rsv) hospitalizations in infants study design: prospective epidemiological, observational, one-center cohort study with sample collection. study population: birth cohort of infants born in lyon before and during the rsv circulation period (october to march) with a follow-up until one year old (from birth until the age of 1 year maximum): * estimate birth cohort (n=5,000). * estimate number of rsvh case (n=110). * estimate number of blood cordon associated with a rsvh (respiratory syncytial virus human) case (n=60)

Eligibility criteria:
inclusion criteria: * children born alive at participating centers. * parents living in the rhone alpes auvergne region exclusion criteria: * parents non-willing to participate * parents living outside the region
split or whole liver transplantation? a multicenter retrospective cohort study of patients with benign and malignant liver disease

Conditions: Zhejiang University

Summary: the primary objective of this study was to assess the safety and feasibility of split liver transplantation(slt) for adult hepatocellular carcinoma (hcc) patients, while comparing the prognostic disparities between adult slt and wlt also . liver transplantation (lt) is an effective treatment for end-stage liver disease. as a traditional marginal donor liver, the application of slt in pediatric patients is successful.however, its application in adult liver transplantation, especially in hcc patients, remains controversial. this retrospective study analyze outcomes among adults who underwent slt and whole liver transplantation (wlt) at two centers from january 2018 to august 2022. a 1:1 propensity score matching (psm) analysis was performed based on important donor and recipient variables. baseline characteristics and postoperative outcomes of the above recipients were analyzed and compared. statistical significance was determined using a two-sided p-value threshold of less than 0.05.

the primary objective of this study was to assess the safety and feasibility of split liver transplantation(slt) for adult hepatocellular carcinoma (hcc) patients, while comparing the prognostic disparities between adult slt and wlt also . liver transplantation (lt) is an effective treatment for end-stage liver disease. as a traditional marginal donor liver, the application of slt in pediatric patients is successful.however, its application in adult liver transplantation, especially in hcc patients, remains controversial. this retrospective study analyze outcomes among adults who underwent slt and whole liver transplantation (wlt) at two centers from january 2018 to august 2022. a 1:1 propensity score matching (psm) analysis was performed based on important donor and recipient variables. baseline characteristics and postoperative outcomes of the above recipients were analyzed and compared. statistical significance was determined using a two-sided p-value threshold of less than 0.05.

Eligibility criteria:
inclusion criteria: 1. ≥ 18 years old 2. received a liver transplantation between 2018 and 2022 (3) liver transplantation was performed by slt or wlt exclusion criteria: 1. re-lt 2. multiorgan transplantation 3. survival≤one week after lt 4. incomplete data

Keywords: liver transplantation; propensity score matching; split; whole; hepatocellular carcinoma; prognosis
cycled phototherapy: a safer effective treatment for small premature infants?

Conditions: Hyperbilirubinemia; Premature Newborns; Extremely Low Birth Weight

Summary: cycled (intermittent) phototherapy will be compared to continuous (uninterrupted) phototherapy in the treatment of hyperbilirubinemia (newborn jaundice) in extremely low birth weight newborns in a pilot randomized controlled trial. hypothesis: cycled phototherapy (pt) will provide the same benefits as continuous phototherapy in extremely low birth weight (elbw) infants without the risks that have been associated with continuous phototherapy.

phototherapy (pt) is widely used and assumed to be safe as well as effective in reducing total bilirubin (tb) levels. our recent nichd network trial showed that aggressive use of phototherapy reduces neurodevelopmental impairment (ndi), but may increase deaths among elbw infants. among ventilator treated infants \ 0.05, an error often made in ignoring important potential treatment hazards when power is limited. multiple studies, most performed decades ago in larger infants, found that short on/off cycles of pt (e.g. 15 min on/60 min off, 1 h on/3 h off, or 1 h on/1 h off ) are as effective as uninterrupted pt to reduce tsb. (cycles with \>6 h off pt do not appear to be as effective as uninterrupted pt). the clinical use of uninterrupted rather than cycled pt appears to be based largely on the assumption that pt is safe for all infants.

Eligibility criteria:
inclusion criteria: * birth weight 401-1000 grams * age less than or equal to 24 hours exclusion criteria: * hemolytic disease * major anomaly * overt nonbacterial infection

Keywords: hyperbilirubinemia prematurity extremely low birth weight (elbw) phototherapy cycled phototherapy intermittent phototherapy
clinical effectiveness of 5 different mouthwashes in the treatment of generalised gingivitis

Conditions: Gingivitis

Summary: the aim of the present study is to evaluate the efficacy of 5 mouthwashes, based on different ingredients, in the treatment of generalised gingivitis.

the present clinical study aims to investigate the clinical efficacy of 5 mouthwashes based on different active substances. the study include 180 patients divided into 6 groups of 30 patients, each group rinse with one of the following mouthwashes - mouthwash based on essential oils (menthol, thymol and eucalyptus), mouthwash based on essential oils (menthol, thymol and eucalyptus) and 0.12% chlorhexidine, mouthwash based on 0,8 % hydrogen peroxide, mouthwash based on prebiotic, water based on 0.2% chlorhexidine, placebo mouthwash. inclusion criteria are: generalized gingival inflammation, plaque index of turesky, 1970 \> 1.95, gingival index of loe \& silness, 1963 \> 0.95, no systemic diseases, no systemic medication, lack of severely damaged teeth, no large fillings, no orthodontic treatment. patients are motivated and instructed to maintain proper and optimal personal oral hygiene. all participants undergo professional mechanical plaque removal. after instrumentation participants are instructed to rinse with 15 ml mouthwash 2 times a day for 21 days. researchers control the amount of mouthwash used by giving a new bottle of mouthwash with the required amount for 1 patient for 1 week at the beginning of each week and taking back the bottle from the previous week. during the study period, patients are monitored on days 14 and 21, examining plaque index of turesky, 1970, gingival index of loe \& silness, 1963, bleeding index of ainamo \& bay, 1975, side effects like staining, burning itching, oral lesions. at the end of the study (day 21), patients complete a questionnaire.

Eligibility criteria:
inclusion criteria: * plaque index (turesky, 1970) \> 1,95; * gingival index (loe \& silness, 1963) \> 0,95; * bleeding index (animo \& bay, 1975) \> 30 %; * no systemic diseases; * no systemic medication. exclusion criteria: * severely destroyed teeth; * crowns; * non correct obturation class ii and v; * orthodontic treatment; * third molars.

Keywords: gingivitis mouthwashes essential oils chlorhexidine gluconate hydrogen peroxide prebiotics chlorhexidine
a pilot trial to assess the impact of acupuncture on post-mastectomy pain, nausea, anxiety and ability to cope

Conditions: Breast Cancer

Summary: the purpose of the study is to compare the effect of acupuncture to the standard of care (control group) on pain, nausea, anxiety, ability to cope, costs and length of hospital stay in post-mastectomy patients at abbott northwestern hospital.

about 40 subjects will be participating in this study. following qualification for the study, participants will be randomly assigned by chance to receive either acupuncture or to receive the standard of care without an integrative medicine session. * one group will receive acupuncture after surgery. acupuncture involves inserting thin, sterile needles at certain points on your body. * the other group will receive the standard of care without an acupuncture session. before surgery participants will complete a demographics questionnaire. after surgery, participants will be visited in their hospital room by either an acupuncturist or another member of the research team. for those assigned to the acupuncture group, participants will receive up to two sessions of acupuncture, at least twelve hours apart. for those assigned to the control group, a research team member will visit the participant in their room up to two times, at least twelve hours apart. during those visits, participants will be asked about pain, nausea, anxiety, and ability to cope at the beginning and end of each treatment or visit. additional information will be gathered from participants hospital charts, such as the type of surgery that was performed, length of hospital stay, and the costs associated with the hospital stay.

Eligibility criteria:
inclusion criteria: * women * 18 years or older * undergoing mastectomy surgery exclusion criteria: * non-english speaking * pregnant * also undergoing an oophorectomy, tram or latissimus flap surgery

Keywords: breast cancer mastectomy acupuncture
probiotics against low grade inflammation and increased intestinal permeability in the elderly

Conditions: Low-grade Inflammation; Increased Intestinal Permeability

Summary: the purpose of this study is to evaluate the ability of a blend of berries and probiotics in reducing low-grade inflammation and intestinal permeability in the elderly. the intervention period is one month. blood and fecal samples will be collected for analysis at baseline and at the end of the intervention with the aim to analyse possible changes in different parameters at the two timepoints. the participants will also be asked to keep a study diary throughout the study period for the documentation of their intestinal health and as a means for checking compliance.


Eligibility criteria:
inclusion criteria: * age \>75 years * crp 2-10 mg/l * ability to fill in a study diary by him/herself exclusion criteria: * intake of antibiotic treatment in the last 4 weeks before inclusion into the study. * currently on corticosteroid treatment * presence of chronic inflammatory disease
international weight control registry

Conditions: Weight Loss; Overweight; Obesity

Summary: the iwcr is a global scientific study aimed at better understanding the opportunities and barriers for reducing the prevalence of obesity by collecting information from people who have experience with weight management in their everyday lives. the investigators seek to gather information on a wide range of weight management experiences, ranging from weight loss and weight loss maintenance to weight gain and inability to lose weight.


Eligibility criteria:
inclusion criteria: * the iwcr is open to anyone 18 years or older who is considering weight loss, is actively engaged in weight loss, or has previously attempted weight loss (including successful and unsuccessful attempts) exclusion criteria: 1. minors, below the age of 18 2. adults who are not able to give informed consent online and complete online surveys

Keywords: weight loss maintenance obesity management
total xenoestrogen body burden in relation to mammographic density, a marker of breast cancer rlisk

Conditions: Breast Cancer Risk

Summary: mammographic density is sensitive to estorgen exposure and constitutes a strong intermediate maker of breast cancer risk. we hypothesize that women with higher serum xenoestrogen levels will have greater mammographic density.


Eligibility criteria:
inclusion criteria: * 55-70 years of age, post menopausal exclusion criteria: * if they have ever used hormone replacment therapy or have ever used tamoxifen or raloxifene, diag. with breast cancer have had breast implants or have had a mastectomy/

Keywords: breast estrogens mammography
a randomized phase iii trial of hyperthermic isolated limb perfusion with melphalan, tumor necrosis factor, and interferon-gamma in patients with locally advanced extremity melanoma

Conditions: Melanoma

Summary: randomized study. initially, 3 patients will be entered on arm i as a pilot feasibility study and to standardize the technical aspects of the study. subsequently, all patients are randomized to arms i and ii. arm i: regional hyperthermia plus regional single-agent chemotherapy. hyperthermic intravenous limb perfusion, hilp; plus melphalan, l-pam, nsc-8806. arm ii: regional hyperthermia plus regional single-agent chemotherapy and biological response modifier therapy. hilp as in arm i; plus l-pam; and tumor necrosis factor (knoll), tnf, nsc-635257; interferon gamma (genentech), ifn-g, nsc-600662.

patients with locally advanced melanoma confined to an extremity (stage iiia or stage iiiab) will be treated in a randomized phase iii study with hyperthermic isolated limb perfusion. one arm of the study will be a standard 60 minute perfusion with melphalan as a single agent. the second arm of the study will combine melphalan, tumor necrosis factor, and interferon-gamma in the isolated limb perfusion reproducing a regimen shown to have 100% response rates in a phase ii european trial. patients will be followed for local response rates, duration of response, treatment toxicity, and disease-free survival.

Eligibility criteria:
disease characteristics: biopsy-proven stage iiia or iiiab melanoma (m.d. anderson staging system) of an extremity, as follows: advanced local disease indicated by 2 or more satellite or in-transit metastases. lower limb regional metastases must be distal to the apex of the femoral triangle except inguinal lymph node metastases. upper limb regional metastases must be distal to the deltoid insertion except axillary lymph node metastases. no evidence of systemic disease outside the involved extremity. recurrent disease subsequent to prior successful limb perfusion allowed. bidimensional directly measurable dermal or subcutaneous lesion required. prior/concurrent therapy: no prior isolated limb perfusion. biologic therapy: at least 1 month since biologic therapy. at least 3 months since regional therapy of the extremity. chemotherapy: at least 1 month since chemotherap.y at least 3 months since regional therapy of the extremity. endocrine therapy: not specified. radiotherapy: at least 1 month since radiotherapy. surgery: not specified. patient characteristics: age: 18 and over. performance status: ecog 0 or 1. hematopoietic: platelets greater than 150,000. hepatic: bilirubin less than 1.5 mg/dl; coagulation profile normal. renal: creatinine less than 2.0 mg/dl. cardiovascular: no evidence of peripheral vascular disease, e.g.: no history of claudication. other: hiv negative. no pregnant or nursing women.

Keywords: interferon-gamma isolated limb perfusion melanoma melphalan tnf
adductor canal blockade vs femoral nerve blockade on muscle strength, mobility and pain after tka

Conditions: Mobility After Total Knee Arthroplasty

Summary: the purpose of the study is to compare the effect of a adductor canal blockade (acb) vs a femoral nerve blockade (fnb), on muscle strength, mobility and pain in patients with severe pain (vas pain score \> 60) after total knee arthroplasty (tka.

the patients will be included after surgery (the first 2 postoperative days). patients reporting vas \> 60 during active flexion of the knee can be included. all included patients will receive 2 blockades at the same time - an acb and a fnb, one blockade with 30ml ropivacaine 0,2% and the other with 30ml saline according to randomization. prior to, and after, the blockades vas pain scores will be obtained, muscle strength (quadriceps and adductors) will be measured using a handheld dynanometer and a timed up and go test will be performed. the study is registered at clinicaltrials.gov after inclusion of the first patient. the reason for this is that we recently became aware of that some journals do not accept a eudract registration. the study was registered at eudract (2012-004554-28)prior to enrollment of patients.

Eligibility criteria:
inclusion criteria: * tka within 72 hours and vas\>60 during 45 degrees active flexion of the knee despite conventional pain medication * informed consent * asa 1-3 * bmi 18-40 exclusion criteria: * unable to communicate in danish * allergic reactions toward ropivacaine * alcohol and or drug abuse * unable to cooperate * known sensory disturbances in the lower limbs

Keywords: total knee arthroplasty adductor canal blockade us-guided nerve blockade
effect of lifitegrast on dry eye disease signs and symptoms

Conditions: Dry Eye

Summary: to determine whether a fall in tear osmolarity precedes improvement in symptoms and signs of dry eye in dry eye patients treated topically with 5% lifitegrast drops for 3 months.

a longitudinal, single-arm, prospective study will recruit up to 30 subjects with moderate to severe dry eye disease. subjects will be \>18 years of age, diagnosed with moderate to severe dry eye (tear osmolarity \> 320 mosm/l and visual analog scale (vas) score \> 40), willing to adhere to twice daily dosing (bid) and follow up visit schedule, have no history of ocular pathology / degeneration / allergy, not on any t-cell modulatory therapy, not have instilled any artificial tears within 2 hours of study visit, and not participating in any concurrent clinical trials. all subjects will complete an informed consent form indicating their voluntary participation in the study. study measurements will be made at baseline (first clinic visit), 2-, 6-, and 12-weeks following lifitegrast therapy and include tear osmolarity (tearlab osmolarity system), vas questionnaire, slit lamp examination for fluorescein corneal staining, tear break up time (tbut), and meibomian gland dysfunction (mgd) grading . at the end of the 3-mo study visit, the subjects will be informed of study completion and exited from the study.

Eligibility criteria:
inclusion criteria: * tear osmolarity \> 320 mosm/l * vas eye dryness \> 40 * no other ocular pathology * no contact lens wear * not currently on t cell modulator * no change in therapy in last 2 months * willingness to adhere to therapy and study visits * patients qualified for prescription of lifitegrast drops exclusion criteria: * contact lens use * eye surgery in past 6 months * use of tear supplements in past 2 hours

Keywords: dry eye tear osmolarity lifitegrast
bone-implant contact surface influence on dental implant stability

Conditions: Missing Teeth

Summary: this study aims to evaluate the changes in the stability and bone-implant contact surface of implants of the same macro-design placed with particle grafting in the fresh extraction socket, without grafting, and placed in healed implant sites.


Eligibility criteria:
inclusion criteria: * having a non-repairable premolar or molar tooth, or an edentulous area where the corresponding teeth have been extracted at least six months ago, * at least 18 years old, * maintaining good dental hygiene, * having a favorable occlusion, * having intact socket walls after extraction. exclusion criteria: * any local or systemic disorders that had contraindications for dental implant insertion, * pregnant and lactating women.

Keywords: dental implant, primary stability, immediate placement