Kornimate/medical-research-clean huggingface dataset:
music for dementia-related sleep problems

Conditions: Dementia; Insomnia

Summary: the study aims to evaluate the effect of listening to music at bedtime on sleep in elderly persons with dementia and sleep problems.

the study is a clinical trial to assess the effect of music listening as intervention for improving sleep in elderly persons with dementia and sleep problems. we use a within-subject design to evaluate the effect of the music intervention. participants are persons above the age of 60 diagnosed with dementia and suffering from sleep problems. we will examine the effect of the intervention on sleep, mood and cognition.

Eligibility criteria:
inclusion criteria: * dementia * sleep problems exclusion criteria: * use of hypnotic medications * substance abuse * severe hearing deficits * not out of bed during daytime
the effects of home use of transcutaneous electrical nerve stimulation on people with knee oa and or chronic knee pain

Conditions: Knee Pain Chronic; Knee Osteoarthritis

Summary: the purpose of the research is to see if the use of transcutaneous electrical nerve stimulation (tens) at home would reduce knee pain and swelling in people with knee oa and/or chronic knee pain.


Eligibility criteria:
inclusion criteria: * the inclusionary criteria for subjects: male or female with the age of 45 years or older, ultrasonography scale of 0-3 for grading of primary knee oa of the knees, pain perceived as a minimum of 3/10 and a maximum of 7/10 weekly average during the baseline period on a 0-10 active vas pain scale, no phobia of electrical stimulation, no pain or anti-inflammatory medication will be taken during the study. injury/pain that began at the knee a minimum of 6-weeks before entering the study. exclusion criteria: * exclusion criteria for the subjects: pregnancy, diabetes mellitus, neuropathy, smoker, uncontrolled htn, past surgery in the region to be treated by tens or had received an intra-articular corticosteroid or hyaluronic acid injection within 6 months before enrollment, arthritis (ra) in the area to be treated by tens, allergic to tape/electrodes, dementia, history of knee joint replacement or tibial osteotomy, undergoing physical therapy, any other major joint pain (e.g., back, hip, or ankle) that could limit functional ability, contraindications to tens (pacemakers, dermatological conditions, and abnormal sensation in the knees), severe medical or neurological conditions (e.g. chronic obstructive pulmonary disease, cardiovascular disease, arteriosclerosis obliterans, cerebrovascular accident, lumbar disc, herniation, and rheumatoid arthritis) or do not utilize stairs in daily living and unable to walk without ambulatory assistive devices. the candidate will be disqualified as a subject for the study if less than 5 days of pedometer use or less than 5 days vas reporting within the prior week's baseline period.
dexamethasone versus dexmedetomidine as adjuncts to serratus anterior plane block

Conditions: Breast Cancer

Summary: modified radical mastectomy is the most commonly performed surgical approach for breast cancer. the procedure enables surgeons to remove the main tumor mass, adjacent glandular tissue and regional lymph nodes. moreover, it provides a cosmetic outcome that clearly surpasses the standard radical mastectomy and allows subsequent breast reconstruction with favorable results. the present randomized study aims to compare the postoperative analgesic effects of dexamethasone and dexmedetomidine as adjuncts to serratus anterior plane block in women undergoing modified radical mastectomy.

modified radical mastectomy is the most commonly performed surgical approach for breast cancer. the procedure enables surgeons to remove the main tumor mass, adjacent glandular tissue and regional lymph nodes. moreover, it provides a cosmetic outcome that clearly surpasses the standard radical mastectomy and allows subsequent breast reconstruction with favorable results. serratus anterior plane block (sapb) with ultrasound guidance is a fascial plane block that proved to be feasible, safe and effective tool for reduction of postoperative pain after thoracic and breast surgeries. in multiple instances, sapb is used with additional adjuncts e.g. dexamethasone or dexmedetomidine to improve analgesic potency and duration.

Eligibility criteria:
inclusion criteria: consecutive american society of anesthesiologists (asa) class i-ii female patients with breast cancer indicated for modified radical mastectomy exclusion criteria: allergy to the study medications . patients will also be excluded if they have history of chronic pain conditions, opioid dependence or if they received prolonged analgesic therapy prior to surgery.
immune response followingtdap vaccine in pregnancy

Conditions: Diphtheria-Tetanus-acellular Pertussis Vaccines

Summary: pregnancy involves changes in immune response. the investigators aim to evaluate the immune response to tdap in pregnancy in comparison to non pregnant women usig proteomics and gene sequencing.

many vaccine-preventable diseases, like influenza, pertussis, and tetanus cause substantial morbidity and mortality in pregnant women, newborns and infants. immunization during pregnancy has the potential to provide protection to the newborn and infant by the transplacental transfer of vaccine-specific maternal antibodies. however, the immunobiology underlying immunization during pregnancy, that leads to the protection of the newborn are not understood. current vaccine formulations were designed for and tested in non-pregnant populations; yet substantial immune modulations take place during different stages of pregnancy and potentially can impact the humoral response following maternal immunization. the investigators thus have insufficient data on quantity and quality of the immune response during pregnancy and how this relates to immunity provided from the mother to the newborn. first, the investigators hypothesize that the nature and breadth of the humoral immune response following vaccination differs in pregnant and non-pregnant vaccinees. next, the investigators hypothesize that the vaccine-specific antibodies that cross the placenta, comprise distinct repertoire features thus, the placenta functions as a differential barrier for antibody transfer. to test these hypotheses, the investigators will use proteomic and genomic/transcriptomic measurements of antibody repertoires in the maternal and cord blood compartments. the measurements will be based on antibody clonal diversity/frequency, v(d)j germline usage and shm, where we expect to find changes in i) vaccine-specific b cell frequency, antibody clonal diversity, germline usage and shm in pregnant women and ii) distinct repertoire features in the transplacental vaccine-specific antibody compartment compared the maternal compartment. the investigators will utilize deep sequencing and proteomic technologies to provide, for the first time, insight into the immunobiology of a promising intervention aimed to prevent early life infectious morbidity and mortality and establish new research avenues for vaccine research in vulnerable populations.

Eligibility criteria:
inclusion criteria for pregnant women (cohort 1): * age between 18-45 years * pregnant women who expected to have tdap vaccine * informed consent form signature inclusion criteria for non pregnant women (cohort 2): * age between 18-45 years * non pregnant women who expected to have tdap vaccine * informed consent form signature exclusion criteria (cohort 1 and 2): * any background immune diseases- autoimmune conditions or cancer. * women who take immunosuppressive/ immunomodulatory medications * a patient has received tdap vaccine in 6 months prior to study entry. * no will to signed the informed consent form.
long-term effect of liam on respiratory performance in niv patients suffering from neuromuscular disease

Conditions: Neuromuscular Disease

Summary: the long-term effect of liam (lung insufflation assist maneuver) on respiratory performance in home non-invasively ventilated (niv) patients suffering from neuromuscular disease will be assessed in a prospective, randomized, cross over, open label study

in advanced neuromuscular disorders, respiratory complications represent the main cause of morbidity and mortality. beside chronic respiratory insufficiency, necessitating a ventilatory support, mostly performed by non-invasive ventilation (niv), cough is impaired due to the muscle weakness, and respiratory physiotherapy becomes an essential part of the management. various techniques have been proposed to improve lung recruitment and cough in neuromuscular patients. the assisted techniques based on a positive pressure insufflation maneuver have shown an improvement in physiological variables on the short term, but there is to date no good-quality prospective study allowing to evaluate the long term efficacy of mechanical cough assistance devices in neuromuscular patients. we designed a randomized, cross over, open label study to assess the long-term effect of liam (lung insufflation assist maneuver) on respiratory performance in niv patients suffering from neuromuscular disease.

Eligibility criteria:
inclusion criteria: * o neuromuscular disease ( progressive muscular dystrophy, for example; duchenne muscular dystrophy, spinal muscular atrophy) * age ≥ 18 years * indication to niv (ongoing ventilation or new patients) * vital capacity ≤ 50% pred * peak cough flow \< 270 l/min * "liam responder" = increased insufflation capacity (≥ + 50%) and peak cough flow (pcf ≥+ 50%) with liam exclusion criteria: * o acute respiratory failure (respiratory acidosis) * home treatment by instrumental cough assistance in the preceding 12 months * ongoing medical treatment of the neuromuscular disease (for ex: corticosteroids in duchenne disease, enzyme therapy in pompe disease) * previous pneumothorax * plan of legal protection * pregnant or breastfeeding women * failure to cooperate * no affiliation to a social security scheme

Keywords: instrumental cough assistance positive pressure insufflation maneuver home mechanical ventilation prospective evaluation
frequency of pulmonary toxicity in patients treated for hodgkin lymphoma

Conditions: Hodgkin Lymphoma

Summary: pulmonary toxicity during hodgkin lymphoma treatment is significant for a variety of reasons, ranging from clinical care to therapeutic innovation and patient outcomes.

understanding chemotherapy-induced pulmonary issues, particularly bleomycin-induced toxicity, might enhance treatment efficacy, side effects, and quality of life for hodgkin lymphoma patients. for hodgkin lymphoma chemotherapy patients with pulmonary difficulties, which result in significant patient morbidity and mortality, early detection, proactive surveillance, and rapid management are required. identifying the prevalence, risk factors, and clinical signs of pulmonary toxicity helps clinicians stratify treatment.

Eligibility criteria:
inclusion criteria: * patients diagnosed with hodgkin lymphoma (hl) receiving treatment. * patients of all ages and both genders. * patients with histologically confirmed hl, as per the who 2016 classification. * patients who have undergone pulmonary function testing and assessment at specified time points during their treatment course. * patients with complete medical records documenting treatment regimens, including chemotherapy and radiotherapy details. exclusion criteria: * patients with a diagnosis of another malignancy. * patients with incomplete medical records or missing data on treatment regimens and pulmonary function assessments. * patients with a history of significant pulmonary comorbidities, such as chronic obstructive pulmonary disease (copd), interstitial lung disease, or pulmonary fibrosis, before hl diagnosis. * patients who are unable to complete pulmonary function tests.
yoga for anxiety in adults

Conditions: Parkinson Disease; Anxiety

Summary: the purpose of this study is to investigate the effect of a telerehabilitation-yoga intervention delivered remotely via videoconferencing on adults with parkinson's disease and anxiety symptoms.

a single group intervention study of adults (18-80 years-old) with parkinson's disease and anxiety symptoms undergoing a 6-week intervention of 30-minute yoga classes delivered remotely through videoconferencing 2-3 times per week. subjects with symptoms of anxiety as indicated by their score on the parkinson's anxiety scale will complete yoga classes delivered at-home with videoconferencing, receiving one-on-one yoga instruction including breathing, postures, and meditation/relaxation for two-three times a week. data collection will occur remotely via videoconferencing at 0-weeks, 6-weeks after a waiting period, 12-weeks after the intervention, and 6-weeks after the last lab visit. data collection will include demographics, mental health questionnaires, motor assessments, enjoyment, usability, and follow-up yoga status. each yoga session will be video recorded to aide in recording adherence, adverse events, and challenges.

Eligibility criteria:
inclusion criteria: * diagnosis of parkinson's disease * symptoms of anxiety as indicated by pas (score ≥ 14) * 18-80 years old * ability to communicate verbally and follow directions * english-speaking * access to wifi and applicable technological device (computer, laptop, tablet, smartphone etc.) * willing to be video recorded during the yoga session * willing to open zoom on their technological device * demonstrates self-reported technological literacy. exclusion criteria: * major depressive disorder (self-report medical history) * injury or condition that could prevent engagement in yoga poses * cognitive impairment or condition that would prevent the participant from understanding the tasks or communicating with the research team * past yoga experience exceeding 5 or more times within the last 2 months * pregnant women (self-report)

Keywords: yoga, anxiety, parkinson's disease, telerehabilitation
fat burning after a meal

Conditions: Postprandial Effect of Carbohydrate Beverage Consumption

Summary: the purpose of the study is to determine how adding a carbohydrate beverage to a meal with different protein levels affects the rate at which one's body burns fats, sugars, and proteins.


Eligibility criteria:
inclusion criteria: * bmi less than 25 kg/m2 * ability to sign the consent form * availability of transportation exclusion criteria: * percent body fat greater than or equal to 25% for males and 35% for females * allergies to any study foods * more than a 10% change in body weight within the past 2 months * current or planned pregnancy * lactation * metabolic illness/disease(s) * active cancer or in short-term remission (less than 3 years) * infectious diseases * alcohol or drug abuse * tobacco use * presence of acute illness * taking medications known to affect energy expenditure and appetite

Keywords: protein carbohydrate lipid oxidation fat sugar juice obesity
hepatitis c virus and the humoral immune system

Conditions: Hepatitis C Virus

Summary: the purpose of this study is to measure specific chemokines, antibodies, and antibody-producing b cells in the blood of patients with hepatitis c virus (hcv) infection. our hypothesis is that changes in chemokine levels affect the development of an effective immune response against hcv.

the long-term goal of our research is to understand why immune complexes (ics) are produced in patients infected with hcv, and whether these complexes affect virus interaction with target cells. we have found that many patients infected with hcv have an increased frequency of circulating b cells, but no evidence that the increased b cells are activated of proliferating. one possible mechanism for such an increase would be a change in levels of chemokines that influence b cell localization and trafficking. our studies are aimed at testing the following hypotheses: 1. one hypothesis is that hcv infection results in increased levels of specific cytokines and chemokines that may affect the motility and localization of immature and mature b cells. an alternative model is that hcv infection leads to chronic antigenic stimulation of b lymphocytes, and that the abnormalities of b cell function associated with hcv infection reflect this chronic antigenic stimulation. 2. a second hypothesis is that autoantibodies and immune complexes present in hcv patient serum contribute to the persistence and spread of viral infection. to test these hypotheses, we are measuring levels of chemokines, the frequency of circulating b cells (mature resting b cells, mature activated b cells, memory b cells, and immature b cells), and the levels and components of ics in the blood of hcv-infected patients. controls include healthy volunteers and patients with chronic liver disease unrelated to hcv infection. no interventions in patient care are planned. when patients elect to undergo standard antiviral therapies under the supervision of their hepatologists, we will study the outcomes of therapy (no virologic response, partial or transient virologic response, sustained virologic response) to determine whether any of the observed alterations in chemokine levels, b cell frequency or activation, or immune complex levels correlate with the patient's response to antiviral therapy.

Eligibility criteria:
inclusion criteria: * healthy volunteers, no liver disease * chronic infection with hepatitis c virus * other chronic liver disease unrelated to hepatitis c virus * subjects in all groups must have sufficiently healthy veins to allow blood collection. exclusion criteria: * any medical condition that, in the opinion of the investigators, precludes the patient's participation

Keywords: hepatitis hepacivirus b lymphocytes chemokines antibodies
anodal tdcs and postural stability in subacute stroke

Conditions: Stroke

Summary: stroke patients experience weakening of muscles on the affected side. damage to the motor cortex and the pyramidal tract due to a stroke leads to a motor control disorders and co-contraction of trunk muscles due to abnormal levels of abdominal muscle tension and voluntary movement.

tdcs is known to modulate motor excitability in humans and motor performance is crucial in postural control. studies reports that applying anodal tdcs to the ipsilesional motor cortex improved motor functioning in which the transcranial direct current stimulation may have stimulated preserved areas of the motor cortex to enhance synaptic efficiency along the corticospinal tract. anodal tdcs has been shown to have immediate and short-term effects in stroke but its long-term effects in stroke are still unclear. additionally, the available literature focuses on acute and chronic stages of stroke so we will target subacute stage of stroke. therefore, this study is designed to investigate the short and long-term effects of anodal transcranial direct current stimulation on postural stability in subacute stroke.

Eligibility criteria:
inclusion criteria: * ischemic stroke * sub-acute stroke * minimum score of 18 on pass exclusion criteria: hearing and visual loss/ deficit * recurrent cva * neurological condition affects the cognition * wound at skull * presence of shunt and/or metallic implant at cranial region * brain tumors * musculoskeletal conditions/ surgery in the lower extremities * cognitively compromised
effect of 48 hours of treatment with the natural peptide-hormone glp-1 in patients with chronic heart failure

Conditions: Heart Failure, Congestive

Summary: the purpose of this study is to determine whether 48 hours of glucagon-like-peptide-1 (glp-1) infusion can improve heart function and alter substrate metabolism in non-diabetic patients with heart failure.

heart failure is a major complication in patients with ischemic heart disease. it has been shown that many of these patients have areas of viable myocardium that are not effectively contributing to heart function. further, chronic congestive heart failure is associated with some degree of insulin resistance in both skeletal and cardiac muscle. glp-1 is a naturally occurring peptide hormone that acts as an incretin and has been intensively studied by many groups in association with type ii diabetes and it has clearly shown its glucose lowering potential with very little risk of hypoglycemia in several trials. recently glp-1 has been shown to improve cardiac function in dogs with pace-induced cardiomyopathy, and in an open-labeled study it did improve cardiac function in patients with acute myocardial infarctions. comparison: 48 hours of treatment with intravenous glp-1 compared to placebo. effect on global and regional left ventricular function, exercise capacity, insulin sensitivity and substrate metabolism.

Eligibility criteria:
inclusion criteria: * chronic congestive heart failure * ischemic heart disease exclusion criteria: * diabetes * exercise limiting disease other than heart failure * congenital heart disease * arterio-venous shunts * renal failure * valvular heart disease

Keywords: chronic congestive heart failure ischemic heart disease insulin resistance
comparison of pharmacodynamics and pharmacokinetics of biphasic insulin aspart 50 to biphasic insulin aspart 70 in type 2 diabetes

Conditions: Diabetes; Diabetes Mellitus, Type 2

Summary: this trial is conducted in europe. the aim of this trial is to compare the pharmacodynamics and pharmacokinetics of biphasic insulin aspart 50 three times a day to biphasic insulin aspart 70 three times a day in non-obese and obese with type 2 diabetes.


Eligibility criteria:
inclusion criteria: * type 2 diabetes for at least 12 months * stable glycaemic control, having been on the existing treatment for at least 1 month * bmi between 23-28 kg/m2 (non-obese) or between 30-35 kg/m2 (obese) * hba1c below 9.0% * willing to eat three main meals per day during the trial period and perform self-monitoring of blood glucose (sbgm) regularly exclusion criteria: * a history of drug abuse or alcohol dependence * blood donation within the last 3 months * currently being treated with systemic corticosteroids, mono amine oxidase (mao) inhibitors, beta-adrenergic blocking agents, anabolic steroids or any other drug affecting blood glucose * severe, uncontrolled hypertension * proliferative retinopathy or maculopathy requiring acute treatment * pregnancy, breast-feeding, intention of becoming pregnant or judged not to be using adequate contraceptive measures (for women of childbearing potential only contraceptive pills and intra uterine devices are considered as adequate contraceptive methods)