Kornimate/medical-research-clean huggingface dataset:
apneic oxygenation with a nasal cannula in the obese and morbidly obese surgical patient

Conditions: Apneic; Oxygenation

Summary: this prospective, randomized, double-blind study is intended to enroll a total of 100 patients with a bmi ≥ 40 kg/m2 and another 100 patients with a bmi ≥ 30 kg/m2 (but less than 40 kg/m2) undergoing surgery with general endotracheal anesthesia at parkland hospital. patients will be randomized to receive either 15 l/min o2 or 15 l/min air from a standard nasal cannula during a simulated prolonged laryngoscopy. the anesthesia provider will do a direct laryngoscopy to ensure that the patient has a cormack-lehane grade i-ii airway. patients who have grade iii-iv airways will be excluded from further study procedures and not analyzed. the rest of the anesthetic will not deviate from the standard of care. anesthesia providers will be blinded as to whether patients are receiving oxygen or air during the apneic period.


Eligibility criteria:
inclusion criteria: * 18-80 years old * obesity (bmi ≥ 30 kg/m2 ≤ 40 kg/m2) * morbid obesity (bmi ≥ 40 kg/m2) * scheduled for a non-emergent operation that requires general endotracheal anesthesia * willing and able to consent in english or spanish * no current history of advanced pulmonary or cardiovascular disease exclusion criteria: * age less than 18 or older than 70 * bmi \< 30 kg/m2 * patient does not speak english or spanish * family or personal history of malignant hyperthermia * patient refusal * monitored anesthesia care (mac) or regional anesthesia planned * pregnant or nursing women * "stat" (emergent) cases * moderate to severe pulmonary disease (e.g., asthma, copd, pulmonary fibrosis, pulmonary hypertension) * respiratory infection within the past 14 days (e.g., pneumonia, bronchitis) * spo2 \< 97% on room air * moderate to severe cardiac disease (e.g., chf, cad, aortic stenosis) * severe gastroesophageal reflux disease (gerd) * nasal obstruction (e.g., tumor) * elevated intracranial pressure (e.g., brain tumor) * history of difficult airway
early oral feeding vs traditional post-operative care in emergency abdominal surgeries

Conditions: Perforated Duodenal Ulcer

Summary: abstract background: enhanced recovery after surgery (eras) protocols have been widely studied in elective abdominal surgeries and have shown better outcomes. however the utility of these protocols in emergency abdominal surgeries has not been widely investigated. objective: to study the outcomes of application of eras protocols in patients undergoing perforated duodenal ulcers repairs in emergency abdominal surgeries. methods: this randomized controlled trial was conducted in surgical unit 1 bbh from august 2018 to december 2019 with a total sample size of 36 patients with the diagnosis of perforated duodenal ulcer. patients were randomly divided in two groups. group a consisted of early oral feeding group and group b consisted of traditional postoperative care group. outcome results studied were the length of hospital stay, duodenal repair site leak, severity of pain (vas score) and duration of post-operative ileus. results were analysed on spss version 20 and chi-square and independent t-test were applied. key words: perforated duodenal ulcer, eras protocol, randomized controlled trial, duodenal repair site leak, length of hospital stay, vas score, post-operative ileus


Eligibility criteria:
inclusion criteria: * all patients older than 15 years with acute abdominal symptoms admitted in er department, suspected as perforated duodenal ulcer and operated within 24 hours of admission by emergency department surgeon. exclusion criteria: * patients presenting with the following criteria were excluded: * refusal to join the study * peptic ulcers with both bleeding and perforation. * spontaneously sealed off perforations. * malignant ulcers * concurrent extra-abdominal surgery * oral incapacity i.e endotracheal intubation * reoperation within a month * asa grade iii/iv * alternative per operative diagnosis.

Keywords: perforated duodenal ulcer enhanced recovery after surgery (eras) protocol randomized controlled trial duodenal repair site leak length of hospital stay visual analog score post-operative ileus
non-inferiority of gatifloxacin/prednisolone association vs isolated administration in prevention of ocular infection/inflammation

Conditions: Ocular Infection and Inflammation

Summary: the purpose of the study is to evaluate the safety and tolerance of the 0.3% gatifloxacin and 1.0% prednisolone acetate association in eye drops in the prevention of infection and inflammation after refractive surgery (lasik) and also demonstrate the non-inferiority of the efficacy of this association compared to the administration of 0.3% gatifloxacin and 1.0% prednisolone acetate as isolated eye drops formulations. the study treatment is randomized, double-masked, with 2 parallel arms. each patient's participation lasts 29 days, with 15 days of study treatment administration after the ocular surgery is performed. candidates for the study are patients with indication for ocular refractive surgery (lasik) for correction of visual acuity.


Eligibility criteria:
inclusion criteria: * patient is indicated to have an ocular refractive surgery performed (myopia, astigmatism, hypermetropy) by the lasik method. * patient presents a normal eye fundus. * patient has intraocular pressure (iop) ≤ 20 mmhg. exclusion criteria: * surgery and/or previous ocular pathology (presence of scar/change in the cornea, glaucoma, retinopathies, etc.). * patient has diabetes or is immunodepressed. * any systemic infection during the study. * signs and/or symptoms of ocular inflammation/infection (bacterial, viral, fungal, caused by chlamydia, by mycobacterium, acanthamoeba or of allergic etiology). * have used any systemic or topical antibiotics for ocular infection in the previous 14 days. * patient has known hypersensitivity to any of the components of the formulations used in the study.
phase 1 study of ono-7475 with and without ono-4538 in subjects advanced or metastatic solid tumors

Conditions: Advanced or Metastatic Solid Tumors

Summary: to evaluate the tolerability and safety of ono-7475 monotherapy and combinations with ono-4538 in patients with advanced or metastatic solid tumors


Eligibility criteria:
inclusion criteria: * patients with histologically or cytologically confirmed advanced or metastatic solid tumors * ecog performance status 0～1 * patients with life expectancy of at least 3 months exclusion criteria: * patients with history of severe allergy * patients with multiple cancers
remote orthopedic outpatient consultation by help of telemedicine

Conditions: Orthopedic Disorders

Summary: patients from 4 local communities in northern norway referred (either new or follow up) to orthopaedic department, university hospital of northern norway for outpatient consultation, are randomly assigned to either remote consultation by use of telemedicine (camera and screen), or standard consultation at the hospital. there are x-ray facilities also at the remote site. the patients randomized to telemedicine consultation meet special trained nurses at the remote site, but doctor only by video conference. the patients will be followed for up to one year. the primary endpoint is quality of care achieved with the telemedicine consultation as compared to standard outpatient consultation (assessed by questionnaires filled out by the doctor involved). secondary end points are patient satisfaction assessed by questionnaires and economic analyses. the study hypothesis is non-inferiority of telemedicine consultation vs. conventional, outpatient consultation.


Eligibility criteria:
inclusion criteria: * informed consent given * new referred patients to orthopaedic department (outpatient), unn, for conditions suitable for telemedicine consultation * follow up consultation of trauma patients (operated/not operated) * follow up consultation after elective orthopaedic surgery (e.g hip prothesis) * follow up of other orthopaedic patients exclusion criteria: * senile dementia * soldiers, prisoners * patients not talking norwegian, dependent on translator * if specialized procedures are required during follow up (e.g. cat-scan, ultrasound etc) * patients requiring a specific doctor

Keywords: remote consultation/*methods orthopaedics methods telemedicine follow-up study ambulatory care
cryoanalgesia aplication time optimization during nuss procedure

Conditions: Funnel Chest; Excavatum, Pectus

Summary: this study compared standard therapy (multimodal analgesia with 2 minutes cryoanalgesia) versus a novel approach (multimodal analgesia with 1 minute cryoanalgesia) in subject undergoing minimal invasive modyfied nuss procedure with thoracoscopy.

funnel chest deformation may be a great challenge for therapeutic teams due to severe pain in the postoperative period as well as chronic pain. 2 minutes per one intercostal nerve aplication cryoanalgesia as a part of multimodal analgesia is a standard protocol in many countries. this prospective non-randomized study is a single institution pilot study designed to compare standard therapy (control side: multimodal analgesia with 2 minutes cryoanalgesia) versus a novel approach (multimodal analgesia with 1 minute cryoanalgesia) in each patient to address the need for better management of acute and long-term pain in the pediatric population diagnosed with funnel-chest and treated using the modyfied nuss method. all of the patients will receive a standard care according to polish guidelines: multimodal analgesia with regional analgesia (bilateral erector spine plane block) with cryoanalgesia. the right intercostal nerves will be treated with 2 minutes cryoanalgesia (control side). the left side of the chest (left intercostal nerves) will be treated with 1 minute cryoanalgesia (intervention side). the intraoperative cryoanalgesia will be performed using the cryo-s painless device (metrum - cryoflex polska limited). the study will assess the effectiveness of shorter aplication duration time of cryoanalgesia as a method of acute and long-term pain control and safety of the method. specific aim: to determine if, compared with current 2 minutes cryoanalgesia protocol, 1 minute aplication time of cryoanalgesia is effective at the same level when consider pain control and postoperative functioning in each patient. the results were compared in terms of demographics, right versus left side of the chest pain levels, quality and length of rehabilitation and patient satisfaction using the quality of life by modyfied nuss questionnaire.

Eligibility criteria:
inclusion criteria: * patients undergoing pectus excavatum repair with modyfied minimal invasive thoracoscopic nuss technique * informed concent signed for cryolesia exclusion criteria: * age 9 years or below * refuse to receive cryoanalgesia or regional anaesthesia as a primary pain relief

Keywords: nuss procedure cryoanalgesia
cilostazol vs. aspirin in acute non-cardioembolic stroke with cerebral microbleeds

Conditions: Cerebral Microbleeds; Stroke

Summary: the purpose of this clinical trial is to demonstrate that cilostazol is non-inferior to aspirin in terms of efficacy and safety for the secondary prevention of stroke in patients with acute non-cardioembolic ischemic stroke who have concurrent microbleeds. researchers will compare the medication cilostazol with aspirin to assess its efficacy and safety in these patients. participants will: take the medication cilostazol or aspirin daily as part of an antiplatelet drug therapy. have baseline data and follow-up data collected at the time of hospital admission, and then at 3 months, 6 months post-discharge, and annually thereafter up to 4 years. have the primary endpoint set as stroke recurrence, with secondary endpoints being composite vascular events. safety events will include moderate to severe hemorrhage and bleeding at any site.

the plan is to enroll patients with acute non-cardioembolic stroke who have concurrent cerebral microbleeds (cmbs). after enrollment, patients will be randomly assigned to either the cilostazol group (experimental group, cilostazol 100mg, twice daily) or the aspirin group (control group, aspirin 100mg, once daily). the treatment goals for blood pressure, blood sugar, and blood lipids will be strictly controlled according to the relevant guidelines. baseline and follow-up data will be collected at the time of enrollment, and at 3 months, 6 months, and annually (up to 4 years) after enrollment.

Eligibility criteria:
inclusion criteria: * acute ischemic stroke (within 1 month of onset) * non-cardioembolic stroke * presence of cerebral microbleeds (cmbs) confirmed by susceptibility-weighted imaging (swi) exclusion criteria: * previous diagnosis of cerebral amyloid angiopathy (caa) according to the boston 2.0 diagnostic criteria * history of intracerebral hemorrhage highly suspected to be caused by caa-related lobar hemorrhage * severe adverse reactions (such as active bleeding, severe allergies, etc.) to aspirin or cilostazol in the past, leading to non-compliance with medication * requirement for combined anticoagulant therapy * requirement for long-term dual antiplatelet therapy (\>1 month)
(hyoscine butylbromide) for abdominal pain associated with cramping on demand basis

Conditions: Abdominal Pain

Summary: the primary objective of this pilot study is to assess effects of hyoscine butylbromide (hbb) 20 mg in comparison to placebo, when used as needed, as measured by the subject's assessment of intensity of abdominal pain associated with cramping (apc) in the treatment of two episodes.


Eligibility criteria:
inclusion criteria: history of recurrent abdominal pain with cramping (apc) for at least three months. recorded at least two episodes of apc of at least "moderate" intensity (i.e., 5 or above on a 0-10 point scale) lasting one hour in the ediary during the run-in period. exclusion criteria: experiencing daily episode of apc during run-in period active gastrointestinal disease during the past 12 months including malignancy, inflammatory bowel disease, celiac disease or complete or partial bowel obstruction and who have undergone major gastrointestinal surgery with the past 12 months (patients with history of appendectomy, cholecystectomy, bilateral tubal ligation and c-section within past 12 months are allowed in the study).
cannabis and thought disorder in schizophrenia

Conditions: Schizophrenia

Summary: recent studies have suggested a strong relationship between cannabis use and the level of thought disorder in subjects with schizophrenia. moreover, the level of thought disorder has been associated with an increased functional connectivity between the temporal lobe and the putamen. however, the brain mechanisms underlying these two relationships are still poorly known. better understanding these mechanisms is important to improve patients' care, in particular among treatment-resistant patients. the objective of the candi study consists of assessing whether the level of cannabis use in patients with schizophrenia modulates the level of thought disorder via a modulation of the functional connectivity between the temporal lobe and the putamen. analyses will be controlled for the composition of cannabis, in particular the tetrahydrocannabinol / cannabidiol ratio.

25 subjects with schizophrenia and current cannabis use will be recruited in the experimental group. the control group will consist of 25 subjects with schizophrenia but with no cannabis use.

Eligibility criteria:
inclusion criteria: * aged between 18 and 65 * meeting the dsm-5 criteria for schizophrenia * "cannabis user" group: - smoking at least two days per week during the previous months * displaying positive urine screen for cannabis * "non-cannabis user" group: - no episode of cannabis smoking during the previous month * negative urine screen for cannabis + no lifetime criteria for cannabis use disorder (assessment by an addiction specialist). exclusion criteria: * current criteria for axis-1 psychiatric disorder other than schizophrenia * current criteria for any other substance use disorder except for nicotine use disorder * any contraindication for mri * tutorship or curatorship * pregnant or lactating woman

Keywords: schizophrenia ; cannabis
therapy to improve reaching movement in upper limb

Conditions: Stroke; Impairment Upper Limb

Summary: strokes are caused by a bleed in the brain and can be life threatening. one common consequence is upper limb impairment. this causes stroke patients to be unable to use their arms and upper body to do simple tasks such as reaching or grasping. currently, people with stroke undergo rehabilitation, which is usually done through a physical and occupational (daily living skills) therapies to improve their mobility (movement) with their upper limbs. however, this kind of treatment has limitations and often cannot help patients regain total mobility. there are alternative rehabilitation treatments that use new methods and technologies that may be able to help patients with stroke. neuromodulaton therapies using brain-computer interfaces (bci), which connects brain signals directly to a computer, have the potential to help patients. this type of therapy uses assistive devices such as electrical stimulation (electrical shocks or waves) and robots to help restore function to the areas affected by stroke. the aim of this study is to evaluate and the potential benefits that can be achieved by using assistive devices in rehabilitation sessions with stroke patients.


Eligibility criteria:
inclusion criteria: * with response to transcranial magnetic stimulation (tms) * cortical or sub-cortical stroke patients * with a score in the range of 22-44 on fugl-meyer scale or 2-4 on the motor assessment scale * with visible cortical patterns registered by bci * subjects that tolerate electrical stimulation and that present a motor response * subjects with cognitive ability to follow instructions and perform the indicated tasks exclusion criteria: * subjects with neurological injury prior to stroke or more than two events * patients with implanted devices * patients with severe motor paralysis * patients with epilepsy * patient with vision or hearing impairment
attitudes towards disability of nursing and physiotherapy students

Conditions: Disability Physical; Disabilities Multiple; Disability Hearing; Disability, Vision; Disability, Intellectual

Summary: the general objective of this study is to know the attitude towards people with disability of nursing and physiotherapy students in the university of cadiz. this is a descriptive, correlational, transversal and synchronous study.

attitudes determine our behaviour to some extent. health professionals should have a global perspective of disability. they must provide treatment to people with disability and care for them, but also should accept them with no judgements or discrimination. the general objective of this study is to know the attitude towards people with disability of nursing and physiotherapy students in the university of cadiz. method: this is a descriptive, correlational, transversal and synchronous study. a total of 200 students participate in the study (91 from the bachelor's degree in nursing and 109 from the bachelor's degree in physiotherapy). the 'attitudes towards people with disability scale' was used.

Eligibility criteria:
inclusion criteria: * students from the physiotherapy bachelor´s degree of the university of cadiz * students from the nursing bachelor´s degree of the university of cadiz, campus of jerez de la frontera and cadiz exclusion criteria: * none

Keywords: physiotherapy students nursing students disability attitude
latina adolescent depression treatment study

Conditions: Depression

Summary: despite experiencing higher rates of depressive symptoms and similar rates of major depressive disorder (mdd), latina (female) adolescents in the u.s. are significantly less likely than their non-latina white peers to receive treatment for mdd. the purpose of this study is to identify facilitators of and barriers to depression treatment engagement among latina adolescents across patient-, family-, and healthcare provider-levels from the perspectives of these individuals. latina adolescent-parent dyads and healthcare providers will be recruited from community and healthcare settings. separate individual semi-structured interviews will be conducted with latina adolescents (n=12) and their parents (n=12). two focus groups will be conducted with primary care providers (n=6) and mental health providers (n=6) who frequently care for latina youth. qualitative content analysis will be used to analyze the transcripts to determine common themes in facilitators and barriers across stakeholder groups.


Eligibility criteria:
adolescent inclusion criteria: * ages 13-17 * self-identify as hispanic/latina * be first generation (i.e. born outside the us) or second generation immigrants (i.e. one or both parents born outside the us) * have been diagnosed with major depressive disorder or persistent depressive disorder/dysthymia * have been referred to psychotherapy or prescribed medication for depression adolescent exclusion criteria: * currently experiencing acute psychological distress parent inclusion criteria * parent of latina adolescent experiencing depression parent exclusion criteria * not fluent in english or spanish healthcare provider inclusion criteria * self-identify as regularly providing clinical care to latina adolescents with depression * be in a role in which they can refer to or provide depression treatment

Keywords: hispanic americans, adolescent
associated pathologies following luxatio erecta humeri: a retrospective analysis of 31 cases and diagnostic algorithm

Conditions: Shoulder Dislocation

Summary: the aim of this study was to evaluate the clinical outcome of this rare injury with special emphasis on associated pathologies. additionally, we aimed to develop an algorithm for the diagnosis of associated pathologies following leh.


Eligibility criteria:
inclusion criteria: * included for analysis were all patients over 18 years of age who have been treated for leh between at our department. exclusion criteria: * only injuries of the affected shoulder were taken into account, non-shoulder related pathologies were not addressed. * other types of shoulder dislocation except luxatio erecta