Kornimate/medical-research-clean huggingface dataset:
epidemiology of human papillomavirus infection among women living on the maroni and the oyapock rivers

Conditions: Human Papillomavirus Viruses

Summary: cervical cancer is the second most frequent cancer of women in french guiana. studies have shown that populations living in remote villages in the interior of the territory have early sexual relations and that multiple sexual partnerships are frequent. hence, the main objective of the study was to determine the prevalence of hpv in these areas, and the predictive factors and epidemiology of this viral infection. methods - this multicentric cross sectional study aimed the population of women aged 20 to 65 years, living in the remote villages along the maroni and oyapock rivers. women wishing to participate will be included after being informed of the study team schedule through radio address and key opinion leaders. the search for hpv and cytologic examinations will be performed for each woman. 2 samples will be taken from each woman: one sample will be sent to fort de france hospital for cytology, and hpv testing; cytologic analyses will be performed using the 2001 bethesda classification. another sample will be sent to pasteur institute in cayenne for sequencing and detection of e6 and e7 rna which are associated with carcinogenesis. hpv infection will be defined by the detection of viral dna using the greiner-bio-one kit. statistical analysis of the results will use stata software and mapping will use mapinfo.


Eligibility criteria:
inclusion criteria: * women aged from 20 to 65 living in a common maroni rivers (apatou , grand santi, papaichton , maripasoula and the native american territory of upper maroni) and / or oyapock ( saint georges, camopi , three jumps ) * having already had sexual intercourse * having given after information , consent to the inclusion in the study exclusion criteria: * age \ 65 years * being pregnant more than 3 months * have had a hysterectomy * denial of participation
interventions for the management of perineal cancer pain

Conditions: Cancer Rectum; Cancer Vulva; Cancer Vagina

Summary: pain associated with neoplasms may be of somatic, visceral, or neuropathic origin.visceral pain or pain that is mediated by the sympathetic fibers in the perineal area associated with malignancy in the pelvis may be effectively treated with neurolysis of impar ganglion.in recent years, radiofrequency lesioning of the ganglion impar has evolved as a novel non pharmacological technique for the management of patients suffering from intractable perineal pain.


Eligibility criteria:
inclusion criteria: 1. cancer patients aged from 20-70 years old, with lower third cancer rectum, caner vulva, cancer vagina and cancer perineum. 2. the intensity of perineal pain on vas score ≥ 5. 3. unsatisfactory treatment with tramadol (400 mg daily) , pregabalin (150 mg daily) or presence of side effects of tramadol as headache, dizziness, constipation, rash, sweating, dry mouth. 4. included participants should show adequate response to diagnostic ganglion impar block , i.e. reduction of vas pain score \> 50% at least for 2 hours. exclusion criteria: 1. infection of the skin at or near site of needle puncture. 2. coagulopathy or prolonged bleeding time. 3. drug hypersensitivity or allergy to the studied drugs. 4. central or peripheral neuropathy . 5. significant organ dysfunction as respiratory , liver or renal failure. 6. any psychiatric illness that would interfere with the perception and the assessment of pain. 7. vertebral anomalies. -

Keywords: cooled radiofrequency , conventional radiofrequency
interprofessional approach to ultrasound diagnosis and intervention in critical care patients with pneumothorax and/or hemothorax

Conditions: Interprofessional Approach; Ultrasound; Intervention; Critical Care; Pneumothorax; Hemothorax

Summary: investigate the efficacy of interprofessional team approach to ultrasound guided diagnosis and intervention (pigtail or chest tube insertion) in critical care patients with pneumothorax and/or hemothorax. evaluate the safety of the procedure {insertion- related complications. assess the duration of chest tube insertion

pneumothorax is defined as the presence of air in the pleural cavity; it can be secondary to underlying pulmonary pathology or trauma. in trauma, about 40-50% of thoracic injuries develop pneumothorax. traditionally, following the suggestion of the american college of chest physicians and the advanced trauma life support (atls), all traumatic pneumothoraxes must be treated with a pleural drainage that could be chest tube (ct) or pigtail catheter (pc). insertion of pleural drains is a common surgical procedure. percutaneous pleural drainage is the third most performed procedure in the intensive care unit (icu) after vascular catheterization and tracheal intubation. bedside-ultrasound is introducing the advantage of at-time diagnosis and evaluation of different parameters without the need for risky transport of critical patients outside icu and also guiding safe and successful intervention without complications and good learning. .

Eligibility criteria:
inclusion criteria: * age from 21 to 65 years * both sexes. * patients with pneumothorax or hemothorax indicated for chest tube or pig tail insertion according to british thoracic society (bts) june 2022 guidelines for pleural procedures. exclusion criteria: * absolute contraindication: patients in which the lung is completely adherent to the chest wall throughout the hemithorax. * relative contraindications: patients with risk of bleeding in patients: * taking anticoagulant medication. * patients with abnormal clotting profiles, coagulopathies, and platelet defects.
prevalence and economic burden of obesity-related comorbidities in the gulf region: a retrospective, observational study

Conditions: Obesity

Summary: the aim of this study is to assess the annual prevalence of orcs among adult people with obesity in the real-world clinical setting across the gulf region. in addition, the study will describe the annual hcru and associated costs of obesity and orcs, describe the demographics and clinical characteristics of adult people with obesity, as well as estimate the annual incidence and point prevalence of the orcs among adult people with obesity.


Eligibility criteria:
inclusion criteria: 1. local national (male or female) of arab ethnicity, age above or equal to 18 years at index date 2. primary or secondary diagnosis of obesity (bmi above or equal to 30 kg/m2) at index date 3. minimum of 1 visit with bmi recorded between months 1 and 6 following index date, and minimum of 1 visit with bmi recorded between months 7 and 12 following index date. there should be a minimum time gap of 3 months between the bmi records and the bmi must be above or equal 30 kg/m2 at each visit. if there are multiple visits during the 12-month observation period, then a mean bmi above or equal 30 kg/m2 must be maintained during the observation period. exclusion criteria: 1. previous participation in this study. participation is defined as having collected data of the participants in this study already. 2. participation in an interventional trial during the 12-month observation period 3. conditions associated with unintentional weight change 4. participants who underwent bariatric surgery within 18 months prior to the index date 5. participants with non-ambulatory disability diagnosis
asacol acute diverticulitis(diva)study

Conditions: Diverticulitis

Summary: the purpose of this study is to determine whether asacol® 2.4 g/day (400 mg mesalamine) is safe and effective in the treatment of diverticulitis.

this study is designed to evaluate the safety and efficacy of asacol® 2.4 g/day in generally healthy, adult patients who have had an attack of acute diverticulitis. the study will evaluate the safety and efficacy of a 12 week treatment with asacol® followed a 9 month non-treatment observation period in approximately 180 patients with acute diverticulitis.

Eligibility criteria:
inclusion criteria: * a clinical diagnosis of acute diverticulitis * female patients must be postmenopausal (at least 1 year without spontaneous menses) or surgically sterile or have a negative urine pregnancy test and practice acceptable contraception (e.g., abstinence; oral, intramuscular, or implanted hormonal contraception \[at least 3 months prior to enrollment\]; 2-barrier methods \[e.g., condom, diaphragm, or spermicide\]; intrauterine device or verbal report of partner with history of non-reversed vasectomy) * willing and able to participate in the study and provide a signed informed consent exclusion criteria: * presence of diverticular complications (e.g., fistula, abscess, obstruction, stenosis); * active or recent history (within 6 months) of a peptic ulcer; * prior history of irritable bowel syndrome (ibs), as determined by the investigator; * history of major abdominal surgery (as determined by the investigator); * history of gi surgery within 3 months of diagnosis of acute diverticulitis; * history of immunocompromising disease, human immunodeficiency virus (hiv) infection, or acquired immunodeficiency syndrome (aids); * if female patient, active or recent history of endometriosis or dysmenorrhea; * received a dose of a product that contains, or is metabolized to, mesalamine by any route within 4 weeks before the screening visit;
paratracheal force required for occluding the upper esophagus

Conditions: Anesthesia Intubation Complication

Summary: in this study, the median paratracheal force for occluding the upper esophagus are evaluated in anesthetized and paralyzed patients using the up-and-down technique.


Eligibility criteria:
inclusion criteria: * patients who are scheduled for elective surgery under general anesthesia exclusion criteria: * diseases or anatomical abnormalities in the neck, larynx, pharynx or esophagus * aspiration tendency * history of carotid artery diseases or cerebrovascular diseases * suspicious of thrombus in carotid artery on ultrasonographic examination
to evaluate the performance and safety of yvoire volume plus for improvement of mid-face volume

Conditions: Midface Volume Deficit

Summary: a study to evaluate the performance and safety of yvoire volume plus for temporary improvement of mid-face volume

this is a randomized, multicenter, evaluator-blinded, active-controlled, parallel-group design investigation to evaluate the performance and safety of yvoire volume plus versus restylane lyft with lidocaine for temporary improvement of mid-face volume.

Eligibility criteria:
inclusion criteria: * male and female aged between 21 to 75 years (inclusive) * 2 or 3 on the 5-point mfvlrs (mid face volume loss rating scale) * desire cheek augmentation to correct volume deficit in the midface. * agree to use contraception * sign informed consent form exclusion criteria: * have undergone facial plastic surgery, tissue grafting, or tissue augmentation with silicone, fat, or other permanent, or semi-permanent dermal fillers in the midface area * have undergone temporary facial dermal filler injections with ha-based fillers within 12 months, porcine-based collagen fillers within 24 months prior to screening * have mid-face volume deficit due to congenital defect, trauma, abnormalities in adipose tissue related to immune-mediated diseases * have history of anaphylaxis, multiple severe allergies, or allergy to lidocaine, ha products, or streptococcal protein * have history of bleeding disorder * have a tendency to develop hypertrophic scarring or keloid
interleukin-1 (il-1) blockade in acute myocardial infarction (vcu-art3)

Conditions: Acute Myocardial Infarction

Summary: vcu-art3 is a double-blind randomized clinical trial of anakinra high dose vs anakinra standard dose vs placebo in patients with st-segment elevation myocardial infarction (stemi) measuring the effects on the acute rise and fall of the plasma c reactive protein levels during the first 14 days.

vcu-art3 is a double-blind randomized clinical trial of anakinra high dose vs anakinra standard dose vs placebo in patients with st-segment elevation myocardial infarction (stemi) measuring the effects on the acute rise and fall of the plasma c reactive protein levels during the first 14 days

Eligibility criteria:
inclusion criteria: in order to be eligible for this study, patients must meet all the 3 inclusion criteria and none of the exclusion criteria. 1. acute stemi defined as chest pain (or equivalent) with an onset within 12 hours and ecg evidence of st segment elevation (\>1 mm) in 2 or more anatomically contiguous leads that is new or presumably new 2. planned or completed coronary angiogram for potential intervention 3. age\>21 exclusion criteria: * inability to give informed consent * pregnancy * preexisting congestive heart failure (american heart association/american college of cardiology class c-d, new york heart association iii-iv) * preexisting severe left ventricular dysfunction (ef\<20%) * preexisting severe valvular heart disease * active infections (acute or chronic) - excluding hepatitis c virus (hcv)+ with undetectable rna * recent (\<14 days) or active use of anti-inflammatory drugs (not including non-steroidal anti-inflammatory drugs \[nsaids\] or corticosteroids used for iv dye allergy only) * chronic inflammatory disease (including but not limited to rheumatoid arthritis, systemic lupus erythematosus) * active malignancy - excluding carcinoma in situ \[any organ\] and non-melanoma skin cancer * anticipated need for cardiac surgery * neutropenia (absolute neutrophil count\<1,800/mm3)
comparison of lysine clonixinate, ketorolac and metamizole sodium in scorpion stings

Conditions: Scorpion Stings; Pain; Analgesic

Summary: the cases of scorpion stings are matters of medical importance, where mexico is considered as one of the main countries of such public health problem.

the states with the highest incidence of cases in 2018 were jalisco with 47370 bite reports, guerrero with 40672 cases and guanajuato with 40331, according to the national epidemiological surveillance system. due to the high affinity on ion channels, where a cystine inhibitor bmp01, it is directed to the nociceptive ion channel trpv1 to produce pain.pain has been reported to occur in approximately 97% of patients they are seen in the emergency room.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of pain by scorpion stings * patients\> 18 years old * clinical diagnosis of scorpion sting poisoning grade i, ii and iii. * chronic degenerative diseases (renal failure, hypertension, liver damage) exclusion criteria: * patients who reject the continuation of medical treatment * patients who are transferred to a unit of second level of care. * patients with pharmacological treatment prior
enhancing the effectiveness of home-delivery based produce prescription program implementation strategies

Conditions: Nutritional Deficiency in Pregnancy

Summary: harris health system is currently participating, along with two other partners, goldifresh inc., and brighter bites, in a cross-sector collaborative home delivery-based produce prescription program (pprx) pilot initiative that provides consistent access to healthy food plus nutrition education to medicaid-eligible pregnant women in harris county, tx, deemed to be at high risk of adverse pregnancy or birth outcomes. the objectives of this study are two-fold: (a) to examine utilization of food basket contents and improvements in diet quality in this home delivery based pprx program, and (b) to evaluate if and the extent to which utilization of food basket contents outcomes improves with support from an interactive ai-based conversational agent to convert food into healthy meals.


Eligibility criteria:
inclusion criteria: * receiving prenatal care at high-risk obstetric clinics * \<= 20 weeks medically-confirmed viable pregnancy * designated as high risk \[age\>=35 years, or obese or overweight (bmi\>=25.0 at pre pregnancy self-report), or prior history of pregnancy hypertension or gestational diabetes\] * within the zip code delivery radius exclusion criteria: * women who were medically recommended bed rest through pregnancy * substance users
the effectiveness of rpsg intervention for nurses during the covid-19

Conditions: COVID-19 Acute Respiratory Distress Syndrome

Summary: the cases of covid-19 are continuing to be confirmed around the world. in the clinical settings, the nurses in evacuation acute wards are main responsibility to undertake the care of emergency patient follow-up and suspected or confirmed covid-19 cases. those nurses have to face the high psychological pressure, unknown panic, fear and so on. thus, the study plans to invite nurses who are working in evacuation acute wards to participate the project called "remote psychological support group (rpsg)". the study supposes "rpsg" could improve nurses' self-efficacy, fear of covid-19, psychological distress, and quality of life.

the cases of covid-19 are continuing to be confirmed around the world. in the clinical settings, the nurses in evacuation acute wards are main responsibility to undertake the care of emergency patient follow-up and suspected or confirmed covid-19 cases. those nurses have to face the high psychological pressure, unknown panic, fear and so on. thus, the study plans to invite nurses who are working in evacuation acute wards to participate the project called "remote psychological support group (rpsg)". the results of this study will establish the effectiveness of rpsg intervention for nurses on self-efficacy, fear of covid-19, psychological distress, and quality of life and identify the feasibility of the rpsg. the results are also critical to improving the quality of care for nurses during the covid-19 outbreak and the rpsg model will establish an important basis for support group in the event of other severe pneumonia with novel pathogens in the future.

Eligibility criteria:
inclusion criteria: * the nurses have to above 20 years old. * the nurses who work in evacuation acute wards. exclusion criteria: * the nurses who have any mental illness.

Keywords: psychological support group nurse covid-19 quality of life
the effect of a plant-based, protein-dense sauce on essential amino acid concentrations and gut fullness in older adults

Conditions: Malnutrition Elderly; Protein Malnutrition

Summary: the goal of this clinical trial is to determine whether meals fortified with plant-based high protein sauce (prosauce) provide better metabolic availability of essential amino acids compared to meals with standard lower-protein sauce without resulting in excessive gut fullness and satiety. the main questions it aims to answer are: does meals with high-protein sauce deliver better metabolic availability of amino acid profile? does this high-protein sauce also not lead to excessive appetite suppression due to its liquid form? researchers will compare high protein sauce to a commercially available standard low protein sauce. participants will consume two meals, either protein-fortified or standard low-protein sauce, in a randomised order with at least a one-week washout period between each meal. the investigators will collect venous blood samples over a 6-hour postprandial period to measure plasma essential (and non-essential) amino acid and insulin concentrations. the investigators will also measure appetite-related hormones from venous plasma and assess subjective appetite using a visual analogue scale, taken in parallel with the blood sample time points.


Eligibility criteria:
inclusion criteria: * aged 60 and over * living independently in the community * capacity to provide informed consent * non-smoking (vaping is considered smoking) * no known medical conditions that might influence the study outcomes, e.g., heart disease, diabetes mellitus, obesity, disthyroidism and other endocrinopathies and renal failure * not taking any medications that might influence the study outcomes e.g., taking anabolic steroids or corticosteroids long term * no clinically diagnosed eating disorders * no severe dislike or allergy to any of the study food * no hospitalisations in the last 6 months * not dieting and weight stable for 3 months before the study (\< 3 kg change in weight) exclusion criteria: * age \< 60y * smoking * food allergies * cognitive and mobility issues * hospitalisation in the last 6 months * known medical conditions that might influence the study outcomes * taking medications that influence the study outcomes

Keywords: plant-based protein sauce older adults amino acid metabolic availability appetite regulation
long-term extension study of the safety and pharmacokinetics of qcc374 in pah patients

Conditions: Pulmonary Arterial Hypertension

Summary: this is a long-term open-label safety extension to the phase 2a study of inhaled qcc374 in adult patients with pah. this study provides the patients who completed the qcc374x2201 study with the option to continue receiving qcc374. the study will monitor the long-term safety, tolerability and efficacy of qcc374 in patients with pah.


Eligibility criteria:
inclusion criteria: * written informed consent must be obtained before any assessment is performed. * subject was enrolled in the qcc374x2201 study and completed per protocol exclusion criteria: * subjects who have started receiving prostacyclin (epoprostenol), prostacyclin analogs (i.e. trepostinil, iloprost, beraprost) or prostacyclin receptor agonists (i.e. selexipag) since the last study drug intake in the qcc374x2201 study. * females who are pregnant, or who plan to become pregnant during the study, or who are breastfeeding * any known factor or disease that may interfere with treatment compliance or study conduct (i.e. drug or alcohol dependence) * subjects who withdrew consent from the study qcc374x2201

Keywords: pulmonary hypertension (ph), increase blood pressure in the pulmonary artery increased blood pressure in the pulmonary vein increased blood pressure in the lung vasculature shortness of breath dizziness fainting leg swelling cough angina pector