Kornimate/medical-research-clean huggingface dataset:
aspiration in acute respiratory failure survivors 2

Conditions: Dysphagia; Aspiration

Summary: the purpose of this study is to learn more about problems with swallowing that could develop in patients who are very sick and need a machine to help them breathe.

the purpose of this study is to learn more about problems with swallowing that could develop in patients who are very sick and need a machine to help them breathe. patients are asked to be in this study because they had problems breathing on their own and therefore needed the help of a machine called a ventilator. in order for this ventilator to push air into the lungs, patients need a tube placed in the throat called an endotracheal tube. the process of placing this endotracheal tube was called intubation. the tube has now been removed, which is a process called extubation. sometimes, people who have had endotracheal tubes can have difficulty swallowing food and liquids for a period of time. this disease is called post-extubation dysphagia (ped). ped is a serious condition and may result in food or liquid going from the mouth into the lungs. this could cause further lung problems. given this risk, doctors sometimes suggest that patients with ped either avoid eating or drinking, or get a feeding tube. currently, nobody knows how often patients develop ped, why they develop it, or the best method to detect it. standard care involves clinicians making educated guesses. this study looks to determine if watching the patient swallow, both with and without a small camera, is an accurate method for detecting ped.

Eligibility criteria:
inclusion criteria: 1. admission to an icu. 2. mechanical ventilation with an endotracheal tube for greater than 48 hours. exclusion criteria: 1. likely persistent contraindications to enteral/oral nutrition administration. 2. pre-existing history of dysphagia or aspiration. 3. pre-existing or acute primary central or peripheral neuromuscular disorder. 4. presence of a chronic tracheostomy (present prior to icu admission). 5. pre-existing head and neck cancer or surgery. 6. coagulopathy resulting in uncontrolled nasal or pharyngeal bleeding. 7. delirium for more than 96 hours after extubation as assessed by confusion assessment method (cam-icu). 8. extubated for greater than 96 hours. 9. inability to obtain informed consent from patient or an appropriate surrogate. 10. age \< 18 years.
monday-focused tailored rapid interactive mobile messaging for weight management 2

Conditions: Obesity; Weight Loss; mHealth; Healthy Diet

Summary: this study, involves the implementation and evaluation of a monday-focused, individually tailored mobile health application to assist overweight or obese adults who would like to achieve a healthful weight. the goal was to evaluate the application of a monday-focused delivery system for the m-trimm2 intervention on participants who worked or lived in areas in or adjacent to johns hopkins east baltimore medical campus.targeting mobile messaging occurred at strategic intervals throughout each week, with the intent of prompting participants to renew their health resolutions each monday combined with lifestyle behavioral education.

the specific aims of this research project are to: 1. develop a targeted delivery system for mobile health messages which focused on improving physical activity and diet, and setting healthy resolutions each week. 2. deliver the m-trimm intervention, which encourages healthy behavior and the weekly renewal of health resolutions. 3. evaluate the effectiveness of this intervention on individuals' weight loss, self-efficacy, and motivation to sustain changes in lifestyle behaviors. 4. assess the benefit of receiving the message content only (in a paper document), versus a scheduled weekly delivery via mobile messaging.

Eligibility criteria:
inclusion criteria: * age ≥ 18 and \<71 * bmi \> 25 * having a phone that was capable of receiving text-messages and being willing to receive text-messages exclusion criteria: * age \<18 or ≥ 71 * bmi ≤ 25 * not having a phone that was capable of receiving text-messages or not being willing to receive text-messages

Keywords: obesity mhealth text messages weight loss intervention physical activity diet
perceptions and barriers about cessation of smoking among ibd patients

Conditions: Smoking; Inflammatory Bowel Diseases

Summary: this study will investigate the perception of the relationship between smoking and inflammatory bowel disease by surveying inflammatory bowel disease patients. afterward, the relationship between smoking and inflammatory bowel disease will be explained, and the smoking cessation rate will be investigated three months later.

a survey is conducted on patients with inflammatory bowel disease (ibd). current smoking status, daily smoking amount, smoking period, perception of smoking effect on the induction of crohn's disease (cd) or ulcerative colitis (uc), and perception of the effect of smoking on the course of cd or uc were investigated. moreover, the intention to quit smoking is investigated. after the survey, information on the effects of smoking on cd or ibd is provided, and smoking cessation education is provided. after three months, the patients' smoking behavior was investigated, and the smoking cessation rate was investigated.

Eligibility criteria:
inclusion criteria: * patients previously diagnosed with inflammatory bowel disease or newly diagnosed with inflammatory bowel disease exclusion criteria: * those who do not agree to the survey or smoking cessation education
the effects of 12 weeks pilates-inspired exercise training on functional performance in older women

Conditions: Aging

Summary: the purpose of the present study was to investigate the effects of 12-week pilates-inspired exercise on functional performance in community-dwelling older women.

pilates is an exercise system developed over 70 years ago that has been recently received attention due to its beneficial effects on postural stability, coordination, muscle strength and flexibility. the studies published involving pilates were very different among them regarding intervention period (5, 8, 12 and 24 weeks), frequency (2 and 3 sessions/week) and exercises (mat, mat with accessories, apparatus and others combinations), making meaningful comparison difficult. furthermore, other important physical features to maintain an independent life at older age, such as cardiorespiratory fitness, were accessed in few studies. so, the effective benefits of pilates method on physical fitness of community-dwelling older people remain unclear.

Eligibility criteria:
inclusion criteria: * good health based on clinical examination (doctor's certificate) * good functional capacity(physical examination) exclusion criteria: * current smokers * obese (bmi \>30 kg/cm2) * musculoskeletal limitations * neurologic diseases * cardiovascular diseases * condition that contraindicated exercise * regularly engaged in other physical conditioning program (\>2x/week and/or \>150min/week)

Keywords: pilates method elderly postural balance
patient-reported outcomes of donor site healing using different palatal protection techniques

Conditions: Mucosal Erosion; Gingival Recession

Summary: this study has been initiated to evaluate the question, "what is the best way to protect the palate after a gum graft is removed?" the overall objective is to determine if there is a difference in proms of donor site healing using different palatal post-operative protection techniques.

this study aims to determine if there is a difference in subject-reported outcome measures (proms) when different palatal post-operative protection techniques are used during healing after an autogenous soft-tissue graft is harvested from the palate for periodontal and peri-implant plastic surgery. the secondary objective is to evaluate if there is a difference in the healing of the palatal tissue via photographic and 3d linear and volumetric changes analysis after using the different protective techniques. furthermore, the study will evaluate the time needed for fabrication and intraoral adjustment of each protective barrier and professional preference among the techniques utilized.

Eligibility criteria:
inclusion criteria: * at least 18 years of age * healthy or mild controlled systemic diseases with no functional limitations (asa i or asa ii) * sites with 1 to 3 teeth or implants requiring soft-tissue grafting * minimum palatal thickness of 2 mm * willing to participate and sign an informed consent exclusion criteria: * patients with systemic conditions that could impair wound healing (i.e. diabetes, immunosuppressive, chemotherapy, etc.) * pregnant patients * patients with bleeding disorders or taking anticoagulants * smokers * patients with a history of palatal graft harvesting

Keywords: soft tissue graft pain wound healing
safety and feasibility of electrical isolation of the superior vena cava for paroxysmal atrial fibrillation

Conditions: Paroxysmal Atrial Fibrillation

Summary: the present study is designed as a observational prospective, multicentre, international. the main aim of this study is to evaluate the safety and feasibility of svc isolation with the cb in a prospective manner.

consecutive patients programmed for cryoballoon ablation (cba) for paf will be prospectively enrolled in our study. after pvi is obtained and proven by entrance- and exit block, the svc will be mapped for potentials. if the svc exhibits electrical activity, isolation will be attempted performing a single maximum 180 seconds balloon application. a single 180 seconds application is known to produce a durable lesion. performing a combined approach (pvi together with svc isolation) using the same cryoballoon requires no additional vascular access. therefore no significant raise in complications is to be expected. during a second generation cba the described rate of complications is to be estimated around 2%. transient phrenic nerve palsy in 7.2 %, but reversible in virtually all patients within the end of the procedure. to prevent nervous injury the phrenic nerve (pn) will be tested during ablation of the svc, in the same fashion as performed systematically during ablation of the right sided pulmonary veins.

Eligibility criteria:
inclusion criteria: 1. written informed consent 2. consecutive patients programmed for cryoballoon ablation (cba) for paf will be prospectively enrolled in our study exclusion criteria: 1. age younger than 18 years 2. severe valve disease (mi or ai \> ¾) 3. uncontrolled heart failure, 4. contraindication to general anaesthesia/ deep procedural sedation 5. left atrial thrombus at the pre-procedural transesophageal echocardiogram (tee)
proactive protection with azithromycin and hydroxychloroquine in hospitalized patients with covid-19

Conditions: Virus Diseases; Infection Viral; Corona Virus Infection

Summary: this study explores whether patients acutely hospitalized may have shorter hospitalization and fewer admittances at intensive care units by treatment with azithromycin and hydroxychloroquine.

in the ongoing coronavirus pandemic, covid-19, that arose in wuhan china, there is still sparse data in the course, risk of various complications, and in particular how patients who are hospitalized are best treated to ensure high survival and short hospitalization. despite the rapid spread of the disease globally, there is no solid data yet to recommend any specific treatments, which is why symptomatic, organ supportive therapy including respiratory therapy in acute pulmonary failure is recommended. there has been reported a high incidence of bacterial super-infections in patients with covid-19. patients with covid-19 also have a higher risk of dying because of septic shock. thus, there is an urgent need for treatment that can improve the patient's chance of the shortest hospitalization possible, and treatment that can lower the risk of secondary infection and death. this is a randomized, placebo-controlled, double-blinded multi-center trial evaluating the effect of azithromycin and hydroxychloroquine treatment in patients with covid-19 during hospitalization. the aim of the study is to investigate whether the treatment can shorten hospitalization, reduce the risk of non-invasive ventilation, admittance to intensive care units and death.

Eligibility criteria:
inclusion criteria: * patient admitted to a danish emergency department, lung medical department or medical department * age \>18 years * hospitalized \<48 hours * positive covid-19 test/diagnosis during the hospitalization * signs informed consent exclusion criteria: * if the patient uses \> 5 lo2/min at time of recruitment * known intolerance/allergy to azithromycin or hydroxychloroquine or hypersensitivity to quinine or 4-aminoquinolinderivates * pregnancy * breastfeeding * neurogenic hearing loss * psoriasis * retinopathy * maculopathy * changes in vision field * severe liver disease other than amoebiases * severe gastrointestinal, neurological or haematological disorders * egfr \< 45 ml/min/1.73m2 * clinically significant cardiac conduction disorders/arrhythmias or prolonged qtc interval * myasthenia gravis * uses digoxin * glucose-6-phosphate dehydrogenase deficiency * porphyria * hypoglycemia at any time since hospitalization * severe mental illness which significantly impedes cooperation * severe linguistic problems that significantly impedes cooperation * treatment with sickle alkaloids
caffeine consumption and cataract prevention

Conditions: Cataract

Summary: effect of peroral caffeine consumption on the delay of cataract onset.

several experimental studies have shown that caffeine inhibits cataract development by scavenging reactive oxygen species. evidence from epidemiological studies, however, is controversial. varma et al., found that the incidence of cataract blindness in humans was significantly lower in groups consuming higher amounts of coffee in comparison to the groups with lower coffee intake. moreover, rautiainen et al. showed that the dietary total antioxidant capacity including coffee of middle-aged and elderly women was inversely associated with the risk of age-dependent cataract. another population-based study involving the population residing in beaver dam, wisconsin, did not find a meaningful association between 10-year cumulative incidence of cataract and the amount of caffeine intake. although cataracts can be surgically removed, barriers that prevent access to surgery are a problem in many countries. moreover, no prophylactic treatments are currently available to prevent the onset of cataract. yet estimates indicate that a delay of only 10 years in the onset of cataract could reduce the need for cataract surgery by as much as 50%. the present study aims to investigate whether peroral caffeine consumption on a regular daily basis for a significant period of time and sufficient dose delays cataract development. 12000 eyes of 6000 patients will be included into this study. patient will have to fill out a questionnaire for caffeine consumption habits during lifetime and risk factors for cataract development. further, a complete ophthalmic examination, cataract grading, refraction, visual testing, and biometry will be performed.

Eligibility criteria:
inclusion criteria: * age older than 21 years * cataract exclusion criteria: - age younger than 21 years

Keywords: cataract caffeine
observational follow-up of participants from clinical trial 64,185-202 (nct00850993)

Conditions: Jaundice; Neonatal Hyperbilirubinemia

Summary: observational follow-up of participants from earlier interventional trial 64,185-202 (nct00850993). no interventions were administered during this follow-up study.


Eligibility criteria:
inclusion criteria: participants who received treatment in clinical trial 64,185-202 and for whom informed consent was given for long term safety followup exclusion criteria: participants were excluded by the investigator for medical reasons or by parents/guardians withdrawing consent

Keywords: stannsoporfin hyperbilirubinemia heme oxygenase
efficacy of an oral, killed enterotoxigenic escherichia coli vaccine in prevention of diarrhea in egyptian infants and young children

Conditions: Diarrhea

Summary: this is a randomized, double-blind, placebo-controlled clinical trial performed in egyptian children 6-18 months of age. the primary aim of the study is to determine the protective efficacy of an oral, inactivated whole-cell enterotoxigenic escherichia coli (etec) vaccine against diarrhea associated with excretion of etec that express a vaccine-shared antigen over a one year period of follow-up by active surveillance. the vaccine consists of a mixture of five formalin-killed etec bacteria expressing prevalent etec colonization factors and recombinant cholera toxin b-subunit (killed etec/rctb vaccine). the placebo preparation is heat-killed escherichia coli k-12 bacteria.


Eligibility criteria:
inclusion criteria: 1. willingness of parent to have the child participate; 2. plans to reside in catchment area continuously for at least one year exclusion criteria: 1. global developmental delay 2. severe malnutrition 3. chronic bedridden status 4. serious chronic disorder requiring chronic medication
cbt treatment for internet gaming disorder

Conditions: Internet Gaming Disorder; Gaming Disorder

Summary: for most people, gaming is perceived as a positive activity. in some cases, however, gaming may turn into an addiction with consequences for the individual health, quality of life and everyday life. today, there is a lack of evidence-based interventions to treat this condition, called gaming disorder (gd). this study will evaluate a new manual for treatment of gd, divided into a number of modules and based on cognitive behavioural therapy (cbt). the study is designed as a randomized controlled trial (rct) and will be conducted at a clinic specialized in the treatment of gambling and gaming addiction. participants included in the study will be randomized to one of to groups. the intervention group will receive twelve weeks of individual cbt-treatment while participants allocated to the control group will be put on a twelve-week wait-list. the hypothesis is that the manual based cbt treatment will result in a greater reduction in symptoms of criteria for gd.

the study is designed as a two-armed randomized controlled trial. after inclusion, every participant will be offered an overview of the participant´s psychosocial circumstances. thereafter, the participants will be randomized to one of the two arms. the main arm includes individual cbt treatment following a module-based manual. the manual includes nine main modules and three optional modules addressing different dimensions of gaming disorder, for example thoughts, emotions, and procrastination. between every session the participants are working with home assignments, in order to strengthen helpful behaviours. the participants also report amount of time spent on gaming and other activities every week. participants randomized to the control arm also report their time spent on gaming and other activities every week.the wait-list control has the same duration as the cbt-arm. after the control-period, participants in the control arm will be offered the same treatment as participants in the intervention arm.

Eligibility criteria:
inclusion criteria: * fulfilling 5 out of 9 criteria for igd according to dsm v * ≥ 16 years of age * can read and speak swedish fluidly. exclusion criteria: * somatic or psychiatric disease that is contraindicating or severely complicates the implementation of the intervention (e.g., ongoing psychotic, manic or hypomanic episode or neuropsychiatric condition with severe disability) * ongoing increased suicide risk that is considered to make it inappropriate for the patient to participate in the study (based on evaluation at the structured clinical interview) * have another ongoing psychological treatment with a content similar to that in the current study * plan to start such treatment during the xx weeks that the study is ongoing or has during the last three weeks started or changed medication for any psychiatric problem.

Keywords: psychiatry psychology cognitive behavioural therapy randomized controlled trial addictive behaviour
re-implantation of a fluocinolone acetonide implant for non-infectious uveitis affecting the posterior segment

Conditions: Uveitis

Summary: the purpose of this study is to collect data on patients with severe uveitis that have required re-implantation of the sustained-release fluocinolone drug delivery device due to depletion of study drug in their previous implanted device.

purpose: to collect medical information on a sustained release drug delivery system that delivers the corticosteroid, fluocinolone acetonide, directly into the vitreous cavity of the eye. this system has the potential to maintain therapeutic drug levels in the eye while reducing systemic exposure to the drug to negligible levels. retiserttm is the trade name for the intravitreal fluocinolone acetonide implant. hypothesis: the retiserttm will be a safe and effective method to manage patients with severe uveitis

Eligibility criteria:
inclusion criteria: * non-infectious intermediate, posterior or panuveitis * previous placement of fluocinolone acetonide implant with initial uveitis quiescence and subsequent recurrence of inflammation once implant depleted of drug exclusion criteria: * infectious uveitis

Keywords: uveitis cystoid macular edema (cme) fluocinolone acetonide non-infectious uveitis affecting the posterior segment