Kornimate/medical-research-clean huggingface dataset:
use of g-csf supplemented ivf medium in patients undergoing ivf

Conditions: Infertility; Embryo Development; IVF

Summary: the purpose of this study is to determine whether in assisted reproductive technologies the use of culture medium supplemented with g-csf, a growth factor working on stem cells, may improve the embryo implantation and pregnancy rate in infertile patients undergoing ivf cycles.

in assisted reproductive technologies the rate of pregnancy for cycle and the implantation rate remain low nevertheless the improvement in the last years. in particular also in relatively young reproductive age women nevertheless the good embryos produced and transferred pregnancy rate and implantation rate remain low. recently, it has been showed that culture medium supplemented with g-csf, may improve the embryo outcomes in ivf. in this trial the investigators will test the potential benefits of this culture medium on embryos of patients undergoing ivf. 180 infertile women undergoing ivf no more than 37 years old will be selected. these patients will be assigned to two arms, one experimental and one other of control by a computer generated sequence. after the oocyte retrieval and fertilization by icsi procedure, the fertilised oocyte (2pn)will cultured with the g-csf supplemented culture medium or in normal culture in micro drop of 30microliters under oil until the day of transfer (day five or blastocyst sage embryos). a maximum of two embryos will be transferred. the pregnancy rate, implantation rate and number of blastocyst developped will be the outcomes considered

Eligibility criteria:
inclusion criteria: * infertility * healthy condition, * good ovarian reserve (amh levels more than 1microg/ml) exclusion criteria: * chromosomal defects in the couple, * metabolic diseases (diabetes, etc), * other genetic diseases (thalassemia, cystic fibrosis, etc.)

Keywords: g-csf blastocyst ivf
s. aureus colonization in atopic dermatitis

Conditions: Atopic Dermatitis

Summary: the purpose of this study is to characterize the bacterial strains that colonize children with atopic dermatitis. the investigators hypothesize that rectal cultures will be more sensitive than anterior nares cultures for detecting s. aureus colonization, and that strains of s. aureus colonizing patients with atopic dermatitis will be resistant to commonly used topical antibiotic ointments.

atopic dermatitis (ad) is a chronic inflammatory skin disease characterized by pruritis and eczematous lesions with a worldwide prevalence of 15-20%. the burden of disease is highest in the most developed nations and predominantly affects children, with 50% of cases arising in the first year of life, and most others arising in the first 5 years. there is a well-known increased susceptibility to skin infection with s. aureus in patients with ad, and such infections are associated with clinical deterioration. while it is routine to evaluate for s. aureus colonization in the anterior nares, there is recent evidence suggesting that rectal colonization may be more significant. the significance of colonization site has not been evaluated in the ad population. additionally, while topical antibiotics are a mainstay of treatment in ad, there is no routine data on the resistance to these agents. our aim is to characterize the s. aureus colonization patterns in children with ad, including site of colonization and antibiotic resistance. we will analyze routinely-collected skin culture specimens from children with ad seen at our center and determine antibiotic susceptibility profiles. the significance of colonization site will be analyzed.

Eligibility criteria:
inclusion criteria: * subjects with a diagnosis of atopic dermatitis seen by the columbia university medical center department of dermatology * subjects ages 0 to 18 years exclusion criteria: * those patients in which a definitive diagnosis of ad cannot be made * subjects over the age of 18 years old * subjects with evidence of acute systemic illness * subjects currently taking systemic antibiotics * subjects with viral or fungal skin infection * any individual who declines participation

Keywords: atopic dermatitis bacterial colonization
oblique versus transverse orientation approach for internal jugular venous cannulation in pediatrics

Conditions: Heart; Surgery, Heart, Functional Disturbance as Result; Pediatric ALL

Summary: this study aimed to compare oblique versus transverse orientation approach in jugular venous cannulation in term of cannulation success in pediatric heart surgery patients

sixty patients randomised into two groups, 30 patients in experimental group (oblique orientation) and 30 patients in control group (transverse orientation). all cannulation took place in the operation room. patients underwent general anesthesia and placed in supine position. standard monitoring (electrocardiogram, non-invasive arterial pressure, pulseoxymetry) was carried out during the procedure for all patients. before preparation of the skin, a pre-procedure ultrasound examination was performed to verify internal jugular vein patency, and its diameter was measured. once the side had been chosen, the cannulation was performed following a sterile technique. all procedure were performed by seldinger technique, with 22 gauge iv catheter attached with 3 ml syringe as introducer needle. the vascular puncture was performed under ultrasound guidance, using a single-person technique. with transverse orientation, the transducer was placed transversally over the neck, and once the vein was visible in the middle of the ultrasound image, the needle was inserted in the plane perpendicular to the long axis of the transducer. with oblique orientation, the operator first obtained a transverse view of the vein and then rotated the transducer to 45 degrees (midway) between transverse and longitudinal view.

Eligibility criteria:
inclusion criteria: * patients age 3 months to 12 years old, weight 5-20 kg, male or female * who undergo heart surgery and indicated to have central venous cannulation * american society of anesthesiologist physical class 1-3 * family or representation of the patients agreed to participate in this study and sign informed consent exclusion criteria: * history of surgery in the area of cannulation * already placed central venous cannulation \<72 hours in the same venous * sign of infection, hematoma, emphysema, in the area of cannulation * history of cervical trauma * severe hemostatic disorder (international normalized ratio\>2, thrombocyte \ 1.5 times, activated partial thromboplastin time \> 1.5 times

Keywords: oblique orientation transverse orientation internal jugular venous cannulation ultrasound guided short axis oblique axis
analgesic mechanisms of percutaneous electrolysis

Conditions: Percutaneous Electrolysis; Pain; Analgesia; Pain Modulation; Endogenous Analgesia System

Summary: percutaneous electrolysis is based on the application of a galvanic current through an acupuncture needle. the underlying mechanisms that explain the efficacy of this technique are not completely well understood. the objective is to delve into the neurophysiological analgesic effects of percutaneous electrolysis. participants will be assigned to one of three intervention groups. the analgesic effects of the technique will be evaluated by means of variables related to endogenous pain modulation.


Eligibility criteria:
inclusion criteria: * asymptomatic subjects * signature of the informed consent exclusion criteria: * fear of needles * any pathology or process that causes pain * neurological, rheumatologic, cardiovascular or metabolic diseases * cutaneous alterations and cognitive or sensitivity disorders * pregnancy * recent intake of alcohol or caffeine * vigorous physical activity on the day of testing
building better bones in children

Conditions: Osteoporosis

Summary: calcium is important for healthy bone growth in children. poor bone growth and development during childhood can lead to osteoporosis later in life. this study will evaluate a nutrition education program designed to increase the amount of calcium children receive. the study will determine whether the program will result in long-term dietary changes and healthier bones in children.

increased calcium intake is effective in increasing bone mineral density in children, but the effect disappears when calcium supplements are discontinued. increased dietary calcium from daily food sources may have a greater impact on bone density than that achieved by calcium supplements. however, studies have not yet demonstrated sustained achievement of increased calcium from food sources. in addition, the effects of baseline calcium intake, bone density, and puberty status may influence bone response to increased dietary calcium. this study will develop, implement, and evaluate a behavioral modification-nutrition education (bm-ne) intervention program designed to promote sustained increases in dietary calcium. the study will quantify the impact of increased dietary calcium on bone density during growth and development and will determine whether the presence of risk factors for low bone density influences compliance with the program. participants will be recruited into two groups: a group of healthy children with no known risk factors for low bone density (i.e., no known chronic disease or previous oral steroid exposure), and a group of healthy children with potential risk factors for low bone density (previous fracture from usual childhood activities, daily dietary calcium refusal, lactose intolerance, family history of osteoporosis). children with and without risk factors will be randomly assigned to participate in an intensive bm-ne intervention group or a usual care group that will receive counseling on bone health. the bm-ne program will consist of five group sessions for parents and children over 6 weeks. the program will use individualized plans to increase children's calcium intake to 1500 mg per day. children will be followed for 3 years. primary outcome measures will include daily calcium intake and bone mineral density. data on height, weight, sexual and skeletal maturation, and physical activity will also be collected.

Eligibility criteria:
inclusion criteria * height or weight above the third percentile for age * normal weight (\< 130% of desirable body weight) * english speaking exclusion criteria * significant health condition * medication known to affect growth (e.g., thyroxin, growth hormone, steroid medication) * ritalin or adderall medication * significant developmental or delay impairment (e.g., autism, cerebral palsy, mental retardation)

Keywords: bone mass calcium intake prevention of osteoporosis optimizing peak bone mass bone mineral density
recoups: post-concussion patient reports

Conditions: Brain Concussion; Head Injury

Summary: physical and cognitive rest are recommended as treatment for concussion, but debate persists about the utility of this recommendation for patients recovering from concussion. in addition, patient adherence to physical and cognitive rest recommendations after concussion remains unknown. this study will measure and compare symptom and activity reports in the days and weeks after a concussion among patients randomly assigned to different incentive-based arms.

although physical and cognitive rest are recommended as the hallmark treatment for concussion, debate persists about the utility of this recommendation for patients recovering from a concussion. in addition, patient adherence to physical and cognitive rest recommendations after concussion remains unknown. objective and timely measures of physical and cognitive activity will aid in defining the relationship between physical and cognitive rest and clinical outcomes, such as symptom status, in the days and weeks after a concussion. random assignment to incentive-based arms will be used to measure patient engagement with the study protocol and a dedicated research platform that involves ecological momentary assessment (ema), in which participants report their real-time symptoms and daily activities in response to randomly timed prompts, will be used to help assess the rest and recovery process among pediatric and adult patients after concussion.

Eligibility criteria:
inclusion criteria: * males or females ages 13 to 64 years. * presents with head injury concerning for concussion in line with criteria specified in the most recent consensus statement on concussion in sport, defined as head trauma with neurologic impairment, including, but not limited to somatic (eg, headache), cognitive (eg, feeling like in a fog) and/or emotional symptoms (eg, lability) symptoms. * within approximately 5 days of injury. * ownership of a smartphone to report symptoms and activities. * speak english. * informed consent or parental/guardian permission and child assent for those under 18 years of age. exclusion criteria: * parents/guardians or subjects who, in the opinion of the investigator, may be non-compliant with study schedules or procedures.
novel intervention linking public housing with primary care to prevent diabetes

Conditions: Diabetes Mellitus Risk; Obesity; Cardiovascular Risk Factor

Summary: (sisters health and primary care uniting and preventing diabetes; aka shape up) will consist of: 1) neighborhood dpp intervention: group dpp sessions and individual coaching; 2) preventive care coordination to fqhc: referral, navigation assistance, patient activation, linkage to primary care (community initiated referrals) and linkage to dpp program (fqhc initiated referrals)

shape-up we will use a randomized between groups wait-list design wherein the experimental treatment will be compared to best practices fhcn/fqhc services waitlist control (with an educational supplement for control). at the 24-week point, the waitlist control participants will be invited to receive the intervention. this combines a between groups rct design with a phase change/within-group design for maximum efficiency with a limited n. randomization will occur at the level of the individual participant. to sustain participant interest and to address obesity-related needs, control arm participants will receive best practices services including 1) individual counseling about pre-diabetes risk at baseline; 2) mailed written materials at weeks 6, 12, 18; and 3) as needed additional fqhc primary care services (as mentioned, referral to the dpp obesity intervention and fhcn/fqhc primary care services will be bidirectional. the re-aim framework will guide process and impact evaluation measures of this intervention.

Eligibility criteria:
inclusion criteria: 1. 21 years of age or older 2. body-mass index of \> 25 kg/m2 or waist circumference \>35 inches 3. ada diabetes risk assessment \> at risk for pre-diabetes 4. casual capillary blood glucose \> 110 mg/dl \<200 5. access to phone 6. resident in or surrounding partnering public housing neighborhood and eligible for fhcn services exclusion criteria: 1. exclusions for diseases likely to limit lifespan and/or increase risk of interventions: a) cancer requiring treatment in the past 5 years; b) cardiovascular disease: "yes" response to any item on the modified physical activity readiness questionnaire; uncontrolled hypertension: sbp \>180 mmhg or dbp \>105 mmhg; heart attack, stroke, or transient ischemic attack in the past 6 months; c) lung disease: chronic obstructive airways disease or asthma requiring home oxygen 2. exclusions related to metabolism: a) diabetes at baseline; b) casual capillary blood glucose \>200 mg/dl; c) history of anti-diabetic medication use (oral agents or insulin) except during gestational diabetes; d) pregnant female; e) self-report of disease associated with disordered glucose metabolism: cushing's syndrome; acromegaly; pheochromocytoma; chronic pancreatitis 3. exclusion for conditions or behaviors likely to affect the conduct of the study: a) unable or unwilling to provide informed consent; b) unable to read written english

Keywords: diabetes prevention risk obesity weight loss community based
early molecular detection technique coupled with urinary test of infectious agents responsible of children cap

Conditions: Community-Acquired Pneumonia

Summary: community-acquired pneumonia (cap) of children are a recurrent pathology with multiple severity scores. the etiology is never really identified, and the initial treatment is always based on probabilistic antibiotics, in the case of an bacterial infection, and by the way, potentially severe. molecular tests ("multiplex") allow the simultaneous detection of a huge number of pathogenic agents, virus and bacteria, are now available. this project is based on a new strategy of diagnostic, using a multiplex pcr with quick results, coupled to an antigenic urinary test to allow a complete, quick, etiologic diagnostic as soon as children are supported in emergency. children are randomized in two groups during inclusions : quick diagnostic strategy versus usual practice. analyse will be centralized on anti-infectious treatment optimization, with the aim to better treat patients, minimize the costs, and decrease selection pressure of multi-resistant bacteria.

community-acquired pneumonia (cap) of children are a recurrent pathology with multiple severity scores. almost two out of three cases identified at emergency are treated in ambulatory because patients present a reassuring clinical state. the etiology is never really identified, and the initial treatment is always based on probabilistic antibiotics re-evaluated at h48, in the case of an bacterial infection, and by the way, potentially severe. this old conception is opposed to the new discoveries, more particularly in pediatric units where strictly viral pneumonia are more important than predicted (at least 30 to 50%) that leads to an hyper prescription of antibiotics, useless. molecular tests ("multiplex") allow the simultaneous detection of a huge number of pathogenic agents, virus and bacteria, are now available. aware of the non specificity of the clinical data to guide the diagnostic, this project is based on a new strategy of diagnostic, using a multiplex pcr with quick results (less than 2 hours, for 20 pathogens, including 17 viruses) coupled to an antigenic urinary test to allow a complete, quick, etiologic diagnostic as soon as children are supported in emergency. children are randomized in two groups during inclusions : quick diagnostic strategy versus usual practice. analyse will be centralized on anti-infectious treatment optimization (antibiotics and antiviruses), with the aim to better treat patients, minimize the costs, and decrease selection pressure of multi-resistant bacteria.

Eligibility criteria:
inclusion criteria: * in emergency for a community-acquired pneumonia (according to the international rules based on an hyperthermia \> 38,5°c associated to a radiological opacity) * informed consent * possibility to take samples exclusion criteria: * nosocomial pneumonia * pleuropneumopathy * pneumonia occurring in immunosuppressed and transplanted * patient with proven allergy to antibiotics * inability to perform certain microbiological samples
cardiovascular function in acute leukemia

Conditions: Leukemia, Myeloid, Acute; Leukemia, Lymphoid, Acute; Cardiotoxicity

Summary: an observational, prospective study to describe the rates and predictors of cardiovascular events in patients with acute leukemia.

patients recently diagnosed with acute leukemia and who will initiating chemotherapy will be enrolled and followed serially with blood collection, echocardiogram, arterial applanation tonometry, and questionnaires for 1 year.

Eligibility criteria:
inclusion criteria: * older than 18 years of age, * new diagnosis of untreated acute leukemia (prior treatment for myelodysplastic syndrome or myeloproliferative neoplams or prior treatment with an anthracycline for breast cancer, hodgkin's lymphoma, non-hodgkin's lymphoma or another diagnosis will be included). * signed the informed consent form exclusion criteria: • unable to provide informed consent
neonatal intensive care nurses' assessment of preterm infants' pain and sedation

Conditions: Nurse Care Coordination

Summary: the aim of this study was to investigate the consistency of nicu nurses' assessment of pain and sedation using npass in preterm infants in the nicu

the experience of pain is a common occurrence for infants in nicus, with many undergoing painful procedures for diagnostic or therapeutic purposes. effective pain management is a critical issue, as repeated painful experiences and stress in the early stages of life have the potential to have adverse short- and long-term effects on infant health. although the importance of assessment and management of pain in neonates is well known, these practices still need to be improved in the nicu. firstly, pain and sedation assessment with reliable tools is needed to provide adequate pain management practices. because the evaluation of the pain and sedation level directs the treatment, thus avoiding inadequate or unnecessary treatment applied to the infants. however, the assessment of pain in newborns is a challenging endeavor, due to the inability of this age group to communicate, the existence of variations in pain responses based on age, the lack of training in the recognition of pain in premature infants, and the practical limitations of current assessment tools. therefore, this study aimed to assess the inter-rater reliability of the n-pass in a clinical actual setting. in this context, there needs to be consistency between assessors in pain assessment. as a result, the aim of this study was to investigate the consistency of nicu nurses' assessment of pain and sedation using npass in preterm infants in the nicu.

Eligibility criteria:
inclusion criteria: * working as a nurse in the nicu for at least six months and agreeing to participate in the study * preterm infant exclusion criteria: * less than six months of nicu experience * term infant

Keywords: preterm nurse pain n-pass