Kornimate/medical-research-clean huggingface dataset:
pet mri as a staging tool for head and neck cancer

Conditions: Head Cancer; Neck Cancer

Summary: to explore the use of pet/mri in the staging and pretreatment evaluation of patients with head and neck cancer and to compare this modality to standard pet/ct imaging.

this study is a prospective clinical study whereby an emerging technology, pet/mri will be compared to a more standard imaging modality, pet/ct, using newly diagnosed head and neck cancer patients as subjects. pet/mri will also be used in this study to explore the merits of this new technology in determining extent of disease, functional impact, and potential treatment outcome. in this study, subjects suitable for enrollment will be identified by the investigators involved in the study. these subjects will be identified through contact with these investigators and referred for enrollment per protocol. this protocol will include determining enrollment suitability based on inclusion and exclusion criteria. once accepted as a candidate for the study, the newly diagnosed head and neck cancer patients will undergo both pet/ct and pet/mri imaging within one week of each other. these studies will then be reviewed by a radiologist specializing in head and neck radiology familiar with pet imaging. the studies will be compared for any imaging differences. the imaging findings will then be correlated with pathological findings after surgery to determine if there are any consistent findings that correlate with adverse pathological findings, if found. the specific imaging data points to be determined by a radiologist will be tumor and metastatic disease size, suv uptake, specific anatomic structures involved with tumor, imaging irregularities and characteristics of those imaging irregularities of the involved structures locally and regionally (if present), imaging characteristics of the different phases of mri (t1, t2, etc.), and any other notable imaging characteristic.

Eligibility criteria:
inclusion criteria: * active head and neck cancer that require pet/ct regardless of the point of treatment * tnm staging i or ii exclusion criteria: * patients whose primary treatment option is chemotherapy or radiation therapy (not surgical) * implanted pacemakers * intracranial aneurysm clips * cochlear implants * certain prosthetic devices * implanted drug infusion pumps * neurostimulators * bone-growth stimulators * certain intrauterine contraceptive devices; or * any other type of iron-based metal implants. * mri should not also be used on persons with the presence of internal metallic objects such as bullets or shrapnel, as well as surgical clips, pins, plates, screws, metal sutures, or wire mesh. * subject with breast tissue expanders.

Keywords: head cancer neck cancer
a prospective, pre-market, multi-center study of insignia hip stem in tha to determine implant survivorship and proms.

Conditions: Arthritis (E.G., Degenerative Joint Disease (DJD), Osteoarthritis, and Rheumatoid Arthritis (RA))

Summary: the purpose of this study is to evaluate the survivorship (revision rates) and patient reported outcomes (proms) following implantation of the insignia hip stem in patients undergoing cementless total hip replacement surgery compared to currently available stems used for the same type of surgery. it is hypothesised the 2-year survivorship of the insignia stem is noninferior to the benchmark survivorship of similar stems used in the same type of surgery.


Eligibility criteria:
inclusion criteria: * the patient has signed the study specific, human research ethics committee (hrec) approved, patient information consent form for the use of the study device * primary non-inflammatory degenerative joint disease (including osteoarthritis or avascular necrosis) and/or rheumatoid arthritis * the patient is a candidate for a primary cementless tha. * patients who are informed of the conditions of the study and are willing to participate for the length of the prescribed follow-up period. exclusion criteria: * active or suspected latent infection in or about the affected hip joint and the time of study device implantation. * any mental or neuromuscular disorder which would create an unacceptable risk of prosthesis instability, prosthesis fixation failure or complications in post-operative care. * has bone stock compromised by disease, infection or prior implantation which cannot provide adequate support and/or fixation to the prosthesis. * is immunologically suppressed or receiving steroids in excess of normal physiological requirements (e.g. \>30 days.) * requires revision tha or hip fusion to the affected joint. * has known sensitivity to device materials. * any involvement in an active workers' compensation investigation
the factors associated 30-day mortality after perioperative cardiac arrest in adults undergoing non-cardiac surgery.

Conditions: Cardiac Arrest; Perioperative Complication

Summary: perioperative cardiac arrest (pca) in patients undergoing noncardiac surgery is a rare but potentially catastrophic event associated with high mortality. several studies have highlighted the factors contributing to pca in the surgical population. however, information on outcomes after pca among the surgical population is still limited. our study aims to identify the incidence of pca, 30-days mortality and the factors associated with pca and 30-day mortality after pca in adults undergoing non-cardiac surgery


Eligibility criteria:
inclusion criteria: * patients aged\> 18 years old * history of perioperative cardiac arrest * non- cardiac surgery exclusion criteria: * did not receive cardiopulmonary resuscitation (cpr) during pca * incomplete data regarding 30-day mortality were excluded

Keywords: critical care perioperative cardiac arrest
pregnant women with a breast cancer diagnosed between 2000 and 2014

Conditions: Breast Cancer

Summary: this is a non-interventional, retrospective, multicentre study involving women having had a breast cancer during their pregnancy, diagnosed between 2000 and 2014 (cases) and non-pregnant women having had a breast cancer between 2000 and 2009 (controls).

investigators will explain the purpose of the study to the eligible patients, still alive, and will inform them verbally and in writing, using the information note, of their possibility of refusal. no information will be made for deceased patients. the investigators will complete the case report forms on paper and then will send them by mail.

Eligibility criteria:
inclusion criteria: * women aged 18 or over * confirmed histological diagnosis of invasive breast cancer * no known metastasis * for the cases : * patients pregnant at the time of the first diagnosis * 1st diagnosis between 2000 and 2014 * for the controls : * patients not pregnant at the time of the first diagnosis * 1st diagnosis between 2000 and 2009 exclusion criteria: * patients who have undergone an induced abortion after the diagnosis of breast cancer * patients with a history of breast cancer

Keywords: pregnant women
eyhance autorefraction study

Conditions: Cataract Senile

Summary: since 2018, the tecnis eyhance icb00 lens (johnson\&johnson vision, amo germany gmbh) was introduced, which is a monofocal iol which has the ability of extended depth of focus improving intermediate vision without the photic phenomena specific for the multifocal iols. the tecnis eyhance icb00 is one of our standard iol, routinely used in our clinic. there is no single outcome measurement that can be thought of as summarizing the efficacy of an iol, nevertheless visual acuity and refractive outcome are the most important parameters for evaluation. aim of this study is to determine the comparability and reproducibility of different refraction methods in patients implanted with eyhance lens and compare the outcomes with zcb00 lens.

this a prospective observational study that would include pseudophakic patients that have undergone cataract surgery 2 to 12 months prior. a written informed consent will be obtained from each patient. patients with icb00 or zcb00 implanted lenses will be included. autorefraction measurements will be performed consecutively, each patient will be measured three times with each device. two independent observers will perform subjective refraction and will be masked to the autorefraction outcome. we would like to include 50 eyes with icb00 and 50 eyes with zcb00 lens implanted. for the estimation of sample size, we used data from wang et al. (wang l, misra m, palikaris ig, koch dd. j cataract refract surg 2002; 28: 276-282) that compared the refractive outcome of pseudophakic eyes and determined a mean spherical equivalent of -0.76 + 0.96 d for group i and -0.44 + 1.13 for group ii, thus leading to an effect size of 0.2. the effect size was used for anova test for repeated measurements within factor, with alpha \< 0.05, power of 80% and a correlation of 0.5 between the two groups gave us an estimated of sample size of 42 patient. to allow patient drop out a number of 50 eyes will be included per lens group (in total 100 eyes). when different lenses are implanted (one eye received zcb00 and the other eyhance), than both eyes of the patient will be included.

Eligibility criteria:
inclusion criteria: * 21 years old or above * operated age-related cataract (pseudophakic patient) * tecnis eyhance icb00 or tecnis zcb00 iol implanted within 2 to 12 months prior to study related examination exclusion criteria: * intra- or postoperative complication * patients with severe corneal pathology, severe macular degeneration, severe diabetic retinopathy, etc. that would significantly influence visual outcome * nystagmus or pathologies that would affect patient fixation * pregnancy- for women in reproductive age a pregnancy test will be performed.
influence of specific immunotherapy with pollinex quattro (tree-/grass pollen) on allergen-specific immunoglobulin e (ige) levels

Conditions: Rhinitis, Allergic; Respiratory Tract Infections; Allergy; Allergic Asthma; Allergic Conjunctivitis

Summary: primary goal of this non-interventional study is to evaluate the change in level of allergen-specific ige (east class) after allergen-specific immunotherapy with pollinex quattro with tree and/or grass pollen extracts and their mixtures under medial routine at adults with tree- and/or grass-medicated pollinosis.

in this non-interventional study, the change in level of allergen-specific ige before and after 3 or more years of allergen-specific immunotherapy with pollinex quattro in a patient population with tree and/or grass pollen induced pollinosis and/or asthma will be analyzed. in addition, the change in medication usage, asthma status for asthmatic patients after 3, 4 or 5 years of allergen specific immunotherapy will be evaluated. furthermore, patients will be asked for their change in quality of life after therapy end.

Eligibility criteria:
inclusion criteria: * patients ≥ 18 years * diagnosis of ige-mediated rhinitis, conjunctivitis and bronchial asthma on grass and/or tree pollen * completed allergen-specific immunotherapy with pollinex quattro with tree and/or grass pollen extracts or their mixtures according to smpc effective during immunotherapy exclusion criteria: * contraindication according to summary of product characteristics (smpc) effective during immunotherapy * no additional allergen-specific immunotherapy with another product than pollinex quattro
mindfulness-based mobile applications program

Conditions: COVID-19; Cell Phone Use; Nurse; Mental Health

Summary: the goal of this type of study: quasi-experimental clinical trial . the purpose of this study is to explore the effects of applying mindfulness-based mobile applications program to maintaining mental health of emergency nurses during providing care to covid-19 patients. the main question\[s\] it aims to answer are: 1. to explore the effect of mindfulness-based mobile device-assisted program on care stress of emergency nurses caring for covid-19 patients. 2. to explore the impact of mindfulness-based mobile device-assisted programs on the psychological distress of emergency nurses caring for covid-19 patients. 3. to explore the impact of a mindfulness-based mobile device-assisted program on compassion fatigue in emergency nurses caring for covid-19 patients. participants will mindfulness-based mobile device is provided to experimental group as assistance for 2 weeks. in the contrary, no intervention measure was assigned in the control group. scale exam was performed before and after the program in both groups at the same time.

this study was a quasi-experimental study with two groups of pretest and posttest to facilitate sampling from the emergency room of mackay memorial hospital. emergency nurses at taipei mackay memorial hospital were in the experimental group, and emergency nurses at tamsui mackay memorial hospital were in the control group. these cases are expected to be accepted. there were 54 people in the experimental group and 54 people in the control group. the experimental group received a two-week mindfulness-based mobility device-assisted program. the program is a mobile application developed by researchers and designed for use on smartphones, tablets, and other mobile devices. the program content is facilitated and guided by certified instructors from the center for mindfulness (cfm) at the university of massachusetts medical school. five suitable sound files were provided to guide subjects in practicing mindfulness. each audio file is approximately 10 to 15 minutes in length. the control group did not take any intervention measures. the experimental group was tested on the scale before and after the program, and the control group was also measured at the same time. research tools include the nursing stress scale, psychological distress scale, and compassion exhaustion scale. the spss 20.0 software package was used for statistical analysis and processing of the data, and covariates were used to analyze the results. the findings will help improve mental health by reducing stress, psychological distress and compassion fatigue among emergency nurse practitioners caring for covid-19 patients.

Eligibility criteria:
inclusion criteria: have a license to practice nurses; have worked in the medical center for more than three months; and are emergency clinical nurses who have experience in caring for covid-19 nucleic acid test patients. exclusion criteria: the exclusion criteria were emergency clinical nurses who had received courses related to mindfulness training.
interstage monitoring using an implantable loop recorder: a pilot study

Conditions: Univentricular Heart

Summary: the primary objective of this investigation is to evaluate the feasibility and safety of implantable loop recorder implantation (using the lux-dx™) in newborns undergoing stage 1 palliation. the secondary objective of the investigation is to evaluate the feasibility of continuous measurement of heart rate and arrhythmia using an implantable loop recorder (lux-dx™) during the interstage period. an implantable loop recorder will be placed at the time of chest closure following stage 1 palliation (either at the time of index surgery or delayed). the device will be placed in a subclavicular pouch through the existing sternotomy incision. participants will be in the study for 6 months to 3 years.


Eligibility criteria:
inclusion criteria: * patients with single ventricle physiology undergoing stage 1 palliation in the 1st month of life exclusion criteria: * prematurity (\<36 weeks gestational age) * birth weight \<2.5 kg * hybrid stage 1 palliation (patent ductus arteriosus stenting, bilateral pulmonary artery bands) * presence and/or need for devices sensitive to magnetic fields such as hearing aids, pacemaker, and other implanted devices. * clinical team does not think that the patient is a good candidate
post marketing surveillance study to observe safety and effectiveness of nephoxil ® in s. korea patients

Conditions: Hyperphosphatemia

Summary: the objective of this post-marketing surveillance (pms) study is to assess the safety and effectiveness of nephoxil capsule 500 mg (ferric citrate 500 mg, equivalent to 105 mg ferric iron) in routine clinical settings


Eligibility criteria:
inclusion criteria: 1. adults 19 years of age or older 2. ckd patients undergoing hemodialysis to whom nephoxil capsule administration is deemed necessary for improvement of hyperphosphatemia as per the determination of the investigator 3. patients who received nephoxil capsule for the first time according to the national approval after conclusion of the contract with the study institution 4. those (or his / her legal guardian) who have agreed in writing to participate in the survey exclusion criteria: 1. patients with contraindications to receive nephoxil * patients with hypersensitivity to the active substance or to any of the excipients * patients with hypophosphatemia * patients with abnormal iron metabolism or symptoms of excessive iron (e.g. hemochromatosis) 2. patients who intend to use this drug for non-approved indications 3. patients who participated in pre-market clinical trials with nephoxil 4. patients who took this drug before the starting day of this survey
gender specific differences in postoperative sore throat for ambu® auragain™ laryngeal mask

Conditions: Postoperative Complications; Postoperative Pain

Summary: the purpose of this study is to evaluate gender specific risk factors and the influence of cuff pressure in the occurrence of postoperative sore throat and hoarseness following general anaesthesia using ambu® auragain™ laryngeal mask.

the history and physical examinations of all patients scheduled for surgery are screened preoperatively for exclusion criteria. patient recruitment is conducted by one of the study physicians. after eligibility is confirmed and written informed consent is obtained, enrolled participants are randomized depending on their gender (400 men, 400 women) in a single-blinded manner (patients) 24 hours before the intervention in a 1:1 ratio to low cuff pressure (45 cmh2o) or normal cuff pressure (60 cmh2o). patient questioning via questionnaire is conducted in postoperative anaesthetic care unit, 24h, 48h and 72h until freedom of symptoms.

Eligibility criteria:
inclusion criteria: * elective surgery in ophthalmology under general anaesthesia with laryngeal mask * age \> 18 * informed written consent exclusion criteria: * anticipated difficult airway with indication for awake tracheal intubation * indication for rsi or elevated risk for aspiration; * pregnant or breastfeeding; * age \< 18 years; * obesity * out-patient surgery (geb. 505); * limited mouth opening; * pre-existing hoarseness and sore throat * participant in other studies * unable to provide informed written consent or under guardianship

Keywords: postoperative sore throat and hoarseness (post) laryngeal mask
the management of schizophrenia in clinical practice (mosaic)

Conditions: Schizophrenia

Summary: this study is a disease-based registry designed to follow patients with a dsm-iv-tr (diagnostic and statistic manual of mental disorders, text revision) diagnosis of schizophrenia, schizoaffective disorder, or schizophreniform disorder treated in usual care settings for up to 5 years. the registry seeks to describe the course of disease in schizophrenia, including cognitive function and negative symptoms, its treatment, and its burden of disease for participants, caregivers, clinicians, and society as a whole.


Eligibility criteria:
inclusion criteria: * adult patients, \>/= 18 years of age * dsm-iv-tr diagnosis of schizophrenia, schizoaffective disorder, or schizophreniform disorder * participants presenting with the normal course of care in usual treatment settings * able to read and speak english * able and willing to provide informed consent * able and willing to comply with the study protocol exclusion criteria: * participants enrolled as subjects in clinical trials at registry enrollment * participants anticipating they will be unable to participate in regularly scheduled assessments as per protocol
hemodynamic alterations in liver cirrhosis validated by non-invasive mr compared to invasive assessment

Conditions: Portal Hypertension; Liver Diseases; Liver Cirrhoses; Cirrhosis

Summary: liver cirrhosis is a chronic disease characterized by a progressive accumulation of fibrosis, loss of liver function and portal hypertension leading to several hemodynamic changes.the exact pathophysiological mechanisms causing the hyperdynamic alterations in cirrhosis are not fully elucidated. aim: the aim of the study is to assess hemodynamic alterations in liver cirrhosis by non-invasive mri and echocardiography compared to portal hypertension measured with liver vein catheterization (hvpg, hepatic vein pressure gradient). furthermore, the aim is to explore hemodynamic differences between cirrhotic patients and healthy subjects. study design and cohort: the study has a cross-sectional design and a cohort with 99 patients with liver cirrhosis - with and without complications and 27 healthy volunteers. the patients are recruited at the gastrounit hvidovre university hospital. the day before the first visit patients are hospitalized and fasting overnight. at first visit liver vein catheterization (lvc) and echocardiography are performed. second visit must be performed within 4 weeks after first visit. at the second visit patients are fasting minimum 6 hours before having mr-flow scanning, cardiac-mr and mr-elastography (mr-e). the healthy volunteers are only offered mr-flow scanning, cardiac mr and mr-e as well as urine- and blood tests follow-up for liver-related clinical outcome and mortality in medical records

mr elastography, cardiac scan, phase contrast mri of blood flow compared to lvc

Eligibility criteria:
inclusion criteria: patients with liver cirrhosis or portal hypertension patient of more than 18 and less than 82 years of age exclusion criteria: patients who are unable to give informed consent patients with absolute contraindication for mri pregnant women patient with severe hemodynamic comorbidity

Keywords: hemodynamic assessments echocardiography mr-elastography liver vein catheterization liver cirrhosis cirrhotic cardiomyopathy cirrhotic complications magnetic resonance imaging