Kornimate/medical-research-clean huggingface dataset:
tomato juice for health study

Conditions: Healthy Volunteers

Summary: the primary objective of this study is to determine if tomato-soy juice can reduce inflammation, which is linked to chronic disease

the aim of this study is to improve understanding of how diet can ameliorate the state of chronic inflammation. short term inflammation is an important part of the body's response to injury, but long term inflammation, as happens in the state of obesity, can result in a multitude of secondary problems, like cancer, diabetes, and cardiovascular disease. using a novel tomato-soy juice, we aim to demonstrate the potential of tomato-soy juice for reducing inflammation in adults.

Eligibility criteria:
inclusion criteria: * between 30 and 75 years old * voluntarily agree to participate and sign an informed consent document exclusion criteria: * aged \ 75 years * known allergy or intolerance to tomatoes or soy * bmi \ 45 kg/m2 * blood plasma glucose \> 125 mg/dl * blood plasma/serum triglycerides \> 250 mg/dl * blood plasma/serum cholesterol \> 240 mg/dl * diabetes requiring the use of diabetes pills, insulin, or non-insulin shots * previous bariatric or gastrointestinal surgery affecting absorption * suspected or known strictures, fistulas or physiological/mechanical gastrointestinal obstruction * presence of gastrointestinal or malabsorptive disorders (including crohn's, ileus or ulcerative colitis, or diverticulitis), or nutrient malabsorption disease (such as celiac disease) * presence of autoimmune disease, metabolic disease, liver disorders, or kidney disorders * diagnosis or treatment of certain cancers in the past 3 years * use of tobacco products or marijuana * daily use of anti-inflammatory drugs * use of antibiotics over the previous 3 months * colonoscopy within a month of the study start date or during the study * use of a carotenoid or isoflavone-containing or metabolism-altering supplement for the last 1 month * use of certain medications (prescription or over-the-counter) that may interfere with the study objectives * unable or unwilling to give informed consent or communicate with study staff * other medical, psychiatric, or behavioral factors that in the judgment of the principal investigator may interfere with study participation or the ability to follow the intervention protocol
talking card for asthma

Conditions: Asthma

Summary: the research goal is to explore the use and effects of a custom-recordable audio discharge instruction card (talking card) in the pediatric health care setting. this study will address a primary, experimental research question: can pediatric asthma control be improved through the distribution of a custom-recorded audio asthma instruction card to parents at the health provider's office? secondary, descriptive objectives will be to evaluate feasibility of talking card delivery and to collect and summarize parental reactions to the design and use of the audio discharge instruction card. the specific aims of this study are: 1. to compare the change in mean childhood asthma control test (c-act) scores for children aged 4 through 11 years with uncontrolled asthma receiving a custom-recorded asthma instruction card to the change in mean c-act scores for those receiving usual care. 2. to measure the use and impressions of a custom-recordable audio asthma discharge instruction card among primary caregivers of children with uncontrolled asthma through quantitative and qualitative survey questions. the investigators hypothesize that: 1) asthma control in children 4 through 11 years of age with uncontrolled asthma, as measured by the c-act, will improve to a greater extent among those receiving a custom-recordable audio discharge instruction card than among those receiving usual care.


Eligibility criteria:
inclusion criteria: * child age 4 through 11 years old * english-speaking primary caregiver * enrollment in medicaid insurance company within 12 months of study recruitment (original kansas city site criterion, removed on revision) * diagnosis of asthma (icd-9 code 493.0) within 12 months of study recruitment * visit to study site clinic for asthma within 12 months of study recruitment exclusion criteria: * history of premature birth less than 33 weeks gestation or requirement of a significant level of respiratory care including mechanical ventilation as a neonate * any major chronic illness including but not limited to non-skin cancer, cystic fibrosis, bronchiectasis, sickle cell anemia, endocrine disease, congenital heart disease, congestive heart failure, stroke, severe hypertension, insulin-dependent diabetes mellitus, renal failure, liver disorders, immunodeficiency states, significant neuro-developmental delay or behavioral disorders (excluding mild attention deficit hyperactivity disorder), or other conditions that would interfere with participation in the study * visit to any primary care provider giving asthma action plan advice during the previous month * anticipated departure from study area before study period ends (3-month follow-up)

Keywords: asthma health literacy
novel esophago-jejunal anastomosis method during totally laparoscopic total gastrectomy

Conditions: Gastric Cancer

Summary: laparoscopic gastrectomy became a good option for early gastric cancer. surgical trend is gradually changed to totally laparoscopic gastrectomy from laparoscopy-assisted gastrectomy requiring mini-laparotomy. various types of intracorporeal anastomosis have been introduced for esophagojejunostomy during total gastrectomy. we invented a novel anastomosis method using linear stapler for total gastrectomy. three procedures (jejunal resection, esophageal resection and closure of common entry hole after anastomosis) was performed with only one stapler. therefore, the novel method is simple and fast. also, this new technique is better economically than previously introduced anastomosis using linear stapler because lesser number of stapler is required. we want to demonstrate the feasibility of novel intracorporeal anastomosis method during laparoscopic total gastrectomy.


Eligibility criteria:
inclusion criteria: * histologically confirmed adenocarcinoma in stomach * males or females, aged≥20 years and ≤80 years * without serosa invasion, extraperigastric lymph node metastasis and other organ metastasis stage in preoperative evaluation, (ct1-3n0-1m0) * beyond the indication of esd * tumor location in high body of stomach or requiring total gastrectomy * eastern cooperative oncology group performance status (ecog ps) of 0 or 1 at study entry * american society of anesthesiolosists (asa) score of 1 to 3 * the patient has given their written informed consent to participate in the study exclusion criteria: * simultaneous malignancy in other organ * experience of previous laparotomy * experience of gastric resection including wedge resection * vulnerable subject

Keywords: total gastrectomy intracorporeal totally laparoscopic esophagojejunostomy anastomosis
remote endarterectomy versus suprageniculate femoropopliteal bypass

Conditions: Peripheral Arterial Occlusive Disease; Atherosclerosis

Summary: the objective of this study is to compare remote superficial femoral artery endarterectomy with suprageniculate bypass surgery in the treatment of long occlusions of the superficial femoral artery. the study hypothesis is that patency rates are comparable and therefore the minimal invasive remote superficial femoral artery endarterectomy can be considered in patients presenting with a long occlusion of the superficial femoral artery.

different strategies exist in the treatment of chronic long occlusions of the superficial femoral artery and yet we still suffer a significant percentage of restenosis, re-occlusions and even major amputations, reason for continuous development of new techniques. one such technique is the recently developed minimal invasive remote endarterectomy, which shows promising patency rates and possibly less complications with earlier recovery. a more experienced and the most implemented technique is the suprageniculate femoropopliteal bypass graft, which, when using the saphenous vein, has proved durable. a randomized trial comparing both modalities was lacking so far, what makes the objective of this study a comparison of patency rates between those 2 techniques in a randomized fashion.

Eligibility criteria:
inclusion criteria: * patients presenting with fontaine iib, iii, iv ischemia * long (\>10 cm) occlusion of the superficial femoral artery, with patent popliteal artery and at least 1 patent crural vessel * atherosclerotic disease exclusion criteria: * previous operations on the superficial femoral artery * radiation therapy groin/leg region * diameter superficial femoral artery \< 4 mm * contrast allergy

Keywords: peripheral arterial occlusive disease superficial femoral artery remote endarterectomy suprageniculate bypass surgery blood vessel prosthesis implantation vascular patency
blood sparing strategies: omni-stat routinary use in cardiac surgery. a prospective randomized study.

Conditions: Hemostasis

Summary: the study enrolles all consecutive patients undergoing cardiac surgery at the european hospital, rome. the population undergoes randomization to receive usual surgical hemostasis or added topical application of omni-stat celox. the two populations are followed up prospectively as regarding blood loss and need for blood transfusions, as well as adverse events at 30 days after surgery.


Eligibility criteria:
inclusion criteria: * all patients undergoing heart surgery exclusion criteria: * none

Keywords: ability of topical drug to reduce acute and overall bleeding as well as blood transfusions
the national australian hcv point-of-care testing program - hcv antibody testing minimal dataset

Conditions: Hepatitis C

Summary: the goal of this observational study is to learn if offering a point-of-care screening test for exposure to the hepatitis c virus, before providing a diagnostic test for hepatitis c infection can increase testing, diagnosis and treatment in adults. participants will be recruited from settings that provide services to people with a risk factor for the acquisition of hepatitis c viral infection. the main question it aims to answer is: what proportion of the participants that have been diagnosed with hcv infection have started treatment when their records are reviewed 12 weeks after diagnosis? participants will have one in-person visit where they will provide informed consent and receive a finger-prick rapid result test for hepatitis c infection. participants with no previous hepatitis c infection will have a screening test to see if they have an immune reaction to hepatitis c. participants who know they have been infected with hepatitis c in the past, and all participants with a positive screening test result will then be given a hepatitis c diagnostic test at this visit. no treatment is provided as a part of this study, participants who are diagnosed with hepatitis c infection will be referred to testing locations standard of care for any additional clinical assessments and treatment initiation. a review of the participant's records will be made 12 weeks after their hepatitis c result and their treatment data are gathered.


Eligibility criteria:
inclusion criteria: * provide informed consent * ≥ 18 years of age. exclusion criteria: * is unable or unwilling to provide informed consent

Keywords: point-of-care rapid diagnostic testing hcv
dslt performance in treatment-naïve patients with newly diagnosed open angle glaucoma

Conditions: Open Angle Glaucoma (OAG)

Summary: dslt demonstrates a ≥ 20% reduction of iop from pre-treatment baseline in poag patients naïve of previous glaucoma treatment at 12 months.

dslt enables newly diagnosed patients to remain well controlled and off medications

Eligibility criteria:
inclusion criteria: * primary open angle glaucoma * patients age 30 or greater with an iop of 18-26 mmhg * mild to moderate poag patients (mild or moderate according to the aao ppp guidelines) * dslt procedure exclusion criteria: * history of prior glaucoma treatment - this includes past medication use (in either eye), previous lasers or incisional surgery * angle closure patients * ocular hypertension * baseline vf md of worse than -12db * uncontrolled systemic microvascular disease (eg. htn, dm) * subjects with peri-limbal findings (e.g. melanosis, tumors, extensive pterygium, significant senile arcus and pterygium)

Keywords: glaucoma dslt interocular pressure
dacomitinib plus pd-0325901 in advanced kras mutant nsclc

Conditions: Colorectal Cancer

Summary: this is a phase i/ii multi-center open-label proof of concept study, consisting of two parts. part a of this study is designed to identify the recommended phase 2 dose (rp2d) of the combination regimen of dacomitinib plus pd-0325901 in patients with advanced kras mutant (krasm) non-small cell lung cancer (nsclc). part b is designed to perform a randomized comparison of the combination of dacomitinib and pd-0325901 versus standard of care therapy in patients with advanced krasm nsclc. it is hypothesized that with this combination strategy the progression free survival of patients with krasm nsclc will be doubled.


Eligibility criteria:
inclusion criteria: * histological or cytological proof of advanced non-small cell lung cancer * written documentation of kras (exon 2, 3 or 4) mutation * at least 18 years of age or older * able and willing to give written informed consent * who performance status of 0 or 1 exclusion criteria: * symptomatic or untreated leptomeningeal disease * symptomatic brain metastasis * impairment of gastrointestinal function * uncontrolled infectious disease * left ventricular ejection fraction \< 50% * retinal degenerative disease or with history of uveitis, retinal vein occlusion or retinal detachment other protocol-defined inclusion/exclusion criteria may apply
adult broad learning experiment (able): feasibility study

Conditions: Cognitive Decline

Summary: this study evaluates the feasibility of enrolling and retaining older adults in a 15-week intervention that will implement six factors from early childhood experiences: individualized scaffolding (having a responsive teacher), forgiving environment (allowing the learner to make and learn from mistakes), growth mindset (believing that abilities can develop with effort), open-minded learning (exploring new experiences), serious commitment to learning (adopting a "learning" lifestyle), and learning multiple skills simultaneously. these six factors will be implemented via concurrent classes at the ucr extension center (osher lifelong learning institute).


Eligibility criteria:
inclusion criteria: * 55 years of age or older * fluent in english * have not been diagnosed with a cognitive condition (e.g., mild cognitive impairment, alzheimer's, and dementia) * currently not experiencing a mental health disorder (e.g., anxiety, depression, schizophrenia) * have normal eye vision or corrected-to-normal eye vision * not proficient in any of the three skills that will be taught during the intervention. proficiency of skills will be determined by participants' self-report of their experience with each skill. only potential participants who self-report having less than one or more years of experience with any of the three skills in the past 10 years or as having less than 5 years of experience more than 50 years ago will be considered as being "unfamiliar" with that skill (or skills) and will be qualified to participate in the study. exclusion criteria: n/a
value of robotic rectopexy for the treatment of complex pelvic floor dysfunction

Conditions: Rectal Prolapse; Pelvic Organ Prolapse

Summary: the purpose of this randomized double blind controlled study is to assess the value of robotics for the treatment of complex pelvic floor dysfunction. the main aim is to compare perioperative and functional outcomes to the laparoscopic approach.

pelvic floor dysfunction is a common pathology. the management can be medical or surgical, depending on the location or the severity of the disease. since the large use of laparoscopy for the treatment of pelvic floor dysfunction, interesting and encouraging results have been published. however, so far, a laparoscopic approach has some technical disadvantages like a poor ergonomy, a 2 dimensional vision, an unstable camera and the use of straight instruments. to overcome these natural limitations, robotics has been gaining increasing acceptance in general surgery. several groups have reported their encouraging experience with robotic rectopexy. yet, these studies were not randomized or double blinded. the aim of this study is to evaluate the role of robotics for complex pelvic floor dysfunction and to compare the outcomes to the laparoscopic approach.

Eligibility criteria:
inclusion criteria: * women * proven pelvic floor dysfunction * informed consent exclusion criteria: * age \<18 years old * patient unable to communicate or to understand the study * patient refusing to participate to the study * contraindication to laparoscopy
registration of acute ischemic stroke with large and medium-sized vascular occlusion in southwest china(lmvos)

Conditions: Acute Ischemic Stroke

Summary: this study is designed to observe the treatment options in real-world clinical practice as well as the safety and efficacy of different treatment strategies.

lmvos is a prospective, real-world registry lasting for 22 years. a total of 8000 patients with large- or medium-vessel occlusion will be enrolled.

Eligibility criteria:
inclusion criteria: the clinical diagnosis is acute ischemic stroke with large- or medium- vessel occlusion (the criteria followed the chinese guidelines for the diagnosis and treatment of acute ischemic stroke 2018). informed consent from the patient or surrogate. exclusion criteria: no additional exclusion criteria.
glp-1 receptor agonist use and incidence of retained gastric food on endoscopy

Conditions: Gastric Content Aspiration

Summary: this study will enroll patients ages 18 and over who are in one of the following groups 1) taking a glp-1 receptor agonist medication 2) not taking a glp-1 receptor agonist (control group), are undergoing egs and have appropriately fasted. study data will be collected in the form of qualitatively observing whether the stomach is empty as expected, or contains solid or clinically relevant liquid contents.


Eligibility criteria:
inclusion criteria * adults 18 years of age and older presenting for esophagogastroduodenoscopy (egd) * one of the following groups: * glp-1 receptor agonist cohort: active treatment with any glp-1 receptor agonist therapy within prior 30 days * control cohort: not taking a glp-1 receptor agonist medication * appropriately fasted per asa fasting guidelines exclusion criteria * simultaneous bowel preparation/planned dual endoscopy with colonoscopy * any pre-planned alteration to standard fasting guidelines (asa npo guidelines) * emergency endoscopic procedure * concern for active gi bleeding * food impaction/foreign body as indication for procedure * gastric outlet obstruction/bowel obstruction * achalasia * zenker's diverticulum * history of esophageal or gastric surgery * active pregnancy * chronic daily opioid therapy ≥ 15 mmes per day * prokinetic agent use (i.e. metoclopramide) * inability or unwillingness of subject to give informed consent
validation, implementation, and cost-analysis of a strategy for personalized diagnosis of rare kidney diseases

Conditions: Chronic Kidney Diseases

Summary: chronic kidney disease (ckd) affects about 10% of the world population, with high morbidity and mortality. genetic kidney diseases are increasingly recognized across all age groups and represent over 20% of all the causes of ckd. accurate diagnosis allows necessary and unnecessary diagnostic procedures to be defined, avoids unnecessary treatments, improves prognosis prediction, identifies other family members for genetic counseling, and defines risks for living donor kidney transplantation. the research group coordinated by the principal investigator has recently developed an algorithm for the genetic diagnosis in pediatric and adult patients with ckd. the application of this personalized diagnostic algorithm on a local study led to a global diagnostic yield of 70%, suggesting that this strategy has the potential to substantially improve the diagnostic approach to patients with rare kidney disorders. the aim of this study is to validate and implement these results by extending its application in a multicentric study involving nephrology units that are referral centers for rare kidney diseases at national level.


Eligibility criteria:
inclusion criteria: * proteinuria and/or hematuria in the absence of immune deposits on renal biopsy or immune-mediated glomerulopathy resistant to treatment (e.g., steroids, immunosuppressive drugs); * family history of kidney diseases and/or consanguinity; * extrarenal involvement; * ultrasound evidence of at least two cysts in each kidney or hyperechogenic kidneys or nephrocalcinosis; * persistent metabolic abnormalities (metabolic acidosis or alkalosis without kidney function impairment; calcium phosphate metabolism abnormalities) after exclusion of secondary causes; * availability of clinical information. * signed informed consent form exclusion criteria: * refusal by the patient, parents, or legal guardian to provide informed consent.
combination therapy effect of laser on wound healing and bone regeneration of dental sockets

Conditions: Tooth Extraction

Summary: the goal of this clinical trial is to learn if the laser works to improve wound healing and bone regeneration after tooth extraction. the main question it aims to answer is: does laser therapy improve wound healing and bone regeneration after tooth extraction? researchers will compare a laser to sham laser therapy to see if the laser enhances wound healing and bone regeneration. participants will: have exposure to laser or sham laser therapy immediately after tooth extraction record their pain intensity on days 2, 4, 6 and 14 visit the clinic after 10 days for follow-up again, visit the clinic after 4 months for evaluation


Eligibility criteria:
inclusion criteria: * at least 21 years old, regardless of gender * non-traumatic tooth extraction of the lower jaw is indicated * willing for dental implant surgery * dental appointments are available at the study place * absence of active infection at the extraction site * signed informed permission is provided. exclusion criteria: * pregnant, lactating, and menopausal women * smokers * those having head and neck radiotherapy * those with any sort of acute infection (e.g., periodontal abscess), immune deficiency, or metabolic conditions such as diabetes mellitus and osteoporosis * patients will also be eliminated if they have a complication during surgery, such as bleeding or operational difficulties, or if the procedure takes longer than 90 minutes.

Keywords: tooth socket, laser, wound healing, bone regeneration, pain