Kornimate/medical-research-clean huggingface dataset:
epidural electrical stimulation to support hemodynamic management in individuals with parkinson's disease

Conditions: Hypotension Symptomatic; Parkinson's Disease; Orthostatic Hypotension, Dysautonomic; Multiple System Atrophy (MSA) With Orthostatic Hypotension; Multiple System Atrophy - Parkinsonian Subtype (MSA-P)

Summary: the pd-hemon study aims to evaluate the safety and preliminary efficacy of arc-im therapy (epidural electrical stimulation) to support hemodynamic management in people with typical and atypical parkinson's disease, who suffer from orthostatic hypotension.


Eligibility criteria:
inclusion criteria: 1. \> 18 years old 2. typical or atypical pd (including but not limited to multiple system atrophy, pure autonomic failure, progressive supranuclear palsy) 3. confirmed orthostatic hypotension with a test for verticalization 4. confirmed symptomatic orthostatic hypotension that makes daily activities particularly challenging as determined by the study clinicians 5. must provide and sign the informed consent before any study-related procedures 6. stable medical, physical, and psychological conditions given participant indication as considered by investigators; 7. able to understand and interact with the study team in french or english 8. agrees to comply in good faith with all conditions of the study and to attend all scheduled appointments exclusion criteria: 1. diseases and conditions that would increase the morbidity and mortality of the implantation surgery 2. the inability to withhold antiplatelet/anticoagulation agents perioperatively 3. history of myocardial infarction or cerebrovascular events within the past 6 months 4. unstable or significant medical condition that is likely to interfere with study procedures or likely to confound study endpoint evaluations as determined by the investigator 5. history or presence of major psychiatric disorders or major neurocognitive disorders as considered by the investigators in accordance with the treating physician and treating neurologist 6. major changes in pd treatment planned until the end of the main study phase (such as dbs or dopamine-pump implantation) 7. inability to follow study procedures. 8. spinal anatomical abnormalities precluding surgery 9. presence of any indications requiring frequent mris. 10. current pregnancy or current breastfeeding 11. lack of effective or acceptable contraception for women of childbearing capacity 12. intention to become pregnant during the study 13. unable or unwilling to effectively use the study system or related devices by the participant or caretaker, as determined by the investigator 14. participation in another interventional study that might confound study endpoint evaluations 15. enrolment of the investigator, his/her family members, employees, and other dependent persons

Keywords: orthostatic hypotension parkinson&#39;s disease autonomic failure hypotension
relationship between pelvic floor dysfunctions and lower limb strength and activation in ms patients

Conditions: Multiple Sclerosis; Pelvic Floor Dysfunction

Summary: we aim to investigate the relationship between pelvic floor dysfunctions, core endurance, hip external rotation muscle strength, and tibialis posterior and tibialis anterior muscle activation in patients diagnosed with ms


Eligibility criteria:
inclusion criteria: * edss score between 0 and 4.0 * having access to the internet via a high-speed smartphone or computer * scoring at least 21 points on the moca * having a score of stage 3 or higher on the functional ambulation scale. exclusion criteria: * having hearing or vision problems. * participating in any exercise program. * having accompanying other neurological, cardiovascular, or orthopedic disorders. * a history of an ms relapse or medication change within the last 6 months. * being in a physical condition that prevents participation in exercises. * comorbid conditions that negatively affect oxygen transport (e.g., severe anemia, peripheral artery disease, etc.)

Keywords: pelvic floor multiple sclerosis core endurance tibialis anterior tibialis posterior electromyography
eye movement desensitization and reprocessing (emdr) in complex psychotrauma

Conditions: Complex Post-Traumatic Stress Disorder

Summary: this study wants to demonstrate the effectiveness of combining a positive memory with "recommended" therapy based on emdr in reducing the disturbance that patients with complex psychotrauma may experience. the positive memory will be called "benevolent memory" (sb) or "less worse memory" (smp).

this is an interventional study, prospective, exploratory, comparative, randomized, controlled versus reference treatment protocol, open. patients will be seen 16 times for the purposes of the study. they will be hospitalized during therapy. discharge from hospitalization occurs during follow-up depending on the patient's condition. they will be evaluated over a period of 4 to 6 weeks between the start (day 0 = week 1) and the end of treatment (visit week 12). these visits will coincide with treatment sessions with the emdr ± sb / smp protocol, as part of the support of their complex psychotrauma. at the end of treatment, the patient will be evaluated during follow-up visits at month 1, month 3 and month 6.

Eligibility criteria:
inclusion criteria: * patient suffering from a combination of a period of complex trauma and a disturbance triggered by situations in adulthood; * having signed an informed consent form to participate in the study. exclusion criteria: * protected patient (under legal protection, or deprived of liberty by judicial or administrative decision); * patient seeking legal benefit from participating in the study; * patient previously treated with emdr; * patient unable to understand the information related to the study (linguistic, psychological, cognitive reason, etc.); * untreated epileptic patient; * patient with severe oculomotor disorders; * patient in hypomanic phase; * patient treated with high dose corticosteroids; * patient with alcohol and / or drug misuse in the 7 days preceding inclusion; * pregnant or likely to be (of childbearing age, without effective contraception) or breastfeeding; * patient participating in another clinical trial, or in a period of exclusion from another clinical trial; * patient not beneficiary of a social security scheme.
a study of v950 in people with alzheimer disease (v950-001 am7)

Conditions: Alzheimer Disease

Summary: the purpose of this study is to test the safety, tolerability and the immune response to an investigational vaccine, v950, with or without iscomatrix™ (imx).


Eligibility criteria:
inclusion criteria: * patient has mild to moderate alzheimer disease * women cannot be able to get pregnant * patient has a reliable caregiver, who will attend all visits and answer questions about the patient exclusion criteria: * patient lives in a nursing home or facility * patient has another neurological or neurodegenerative disorder * patient has a history of stroke * patient uses illicit drugs or has a history of drug/alcohol abuse * patient has received blood or blood derived products within 6 months
efficacy of platelet rich plasma in plantar fasciitis

Conditions: Plantar Fascitis

Summary: plantar fasciitis is a common pathology among podiatry moreover the healing time takes several months. the main aim of this study is to evaluate the efficacy of a injection of platelet-rich plasma (prp) versus corticosteroid injection.


Eligibility criteria:
inclusion criteria: * plantar fasciitis * average vas greater than or equal to 5/10 * resistance of medical reference treatment exclusion criteria: * other plantar lesion find on rmi * pregnancy
effectiveness of a digital health application for psoriasis

Conditions: Psoriasis

Summary: this clinical trial with 348 patients with psoriasis aims to investigate the effectiveness of a self-guided online program for patients with psoriasis. patients will be randomized and allocated in a 1:1 ratio to either an intervention group, in which they will receive 12-month-access to an online program for psoriasis in addition to treatment as usual (tau, n = 174), or to a control group, in which they will receive only tau (n = 174). tau is defined as any therapy prescribed or recommended by the gp or specialists (e.g. dermatologist, psychiatrist), which may include topical therapy, phototherapy, pharmacotherapy, psychosocial therapy, etc.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * presence of psoriasis vulgaris or psoriatic arthritis * submission of a specialist medical certificate attesting to the presence of at least one of the following icd-10-gm diagnoses: psoriasis vulgaris (l 40.0, l 40.7), psoriatic arthritis (l40.5, m07.x) * impaired health-related quality of life (dlqi \> 10) * consent to participate * sufficient understanding of the german language exclusion criteria: * presence of another subtype of psoriasis (pustular psoriasis, guttate psoriasis, inverse psoriasis, erythrodermic psoriasis, or drug-induced psoriasis) or psoriatic arthritis without skin involvement * presence of malignancies * presence of other chronic diseases with strong negative influence on quality of life * currently undergoing psychiatric treatment / current presence of a severe psychiatric diagnosis * insufficient language and/or it skills
effects of 6 weeks high-intensity interval training among spinal cord injury

Conditions: INCOMPLETE SPINAL CORD INJURY (ASIA D)

Summary: the training consists of 6 weeks of functional electrical stimulation leg cycling exercise (fes-lce) program. the training program comprises of 2 visits per week. each visit consists of fes-lce for 45 minutes. throughout the 6 weeks program, there will be testing/assessment sessions on week 1, week 3 and week 6. the fes will be applied via surface electrodes and the stimulation intensity based on the participant's tolerance level.


Eligibility criteria:
inclusion criteria: * participants were diagnosed with incomplete spinal cord injury (sci) at least one year prior to participation. * age between 18-75 years old. * both male and female. * have at least 90º bilateral knee flexion. * moderate neurological induce weakness in quadriceps muscle of 1 leg that is responsive to electrical stimulation (moderate weakness was defined as 3/5 or 4/5 on manual muscle testing). * able to perform cycling activity. * normal upper limb function. * able to follow command. exclusion criteria: * had a recent history of trauma to the lower limb. * severely infected skin pressure sore on weight-bearing skin areas. * illness caused by acute urinary tract infection. * uncontrolled spasticity or pain. * history of cardiovascular/cardiorespiratory problem. * orthostatic hypotension. * unhealed decubiti at electrode placement area. * recurrent autonomic dysreflexia. * active heterotopic ossification. * other peripheral or central neurologic injury.

Keywords: high intensity interval training incomplete spinal cord injury muscle strength cardio-respiratory fitness
long-term safety study of adjunctive troriluzole in subjects with obsessive compulsive disorder

Conditions: Obsessive Compulsive Disorder

Summary: the purpose of the study is to evaluate the long term safety and tolerability of troriluzole as adjunctive therapy in subjects with obsessive compulsive disorder (ocd).


Eligibility criteria:
key inclusion criteria: * eligible subjects are those subjects who complete study bhv4157-302 or bhv4157-303 and for whom the investigator believes open-label treatment offers an acceptable risk-benefit profile. * determined by the investigator to be medically stable at the week 10 visit of bhv4157-302 or bhv4157-303, as assessed by medical history, physical examination, laboratory test results, and electrocardiogram testing. * it is required that all women of child-bearing potential (wocbp) who are sexually active agree to use two methods of contraception for the duration of the study key exclusion criteria: * subjects who did not successfully complete 10 weeks of treatment in the bhv4157-302 or bhv4157-303 study. * acute suicidality or suicide attempt or self injurious behavior in the last 12 months. * patients who may have received a non-biological investigational agent in any clinical trial within 30 days or a biological agent within 90 days prior to entry, other than what was received in bhv4157-302 or bhv4157-303;

Keywords: obsessive compulsive disorder ocd troriluzole biohaven
impact of the presence of the corpus luteum on pregnancies obtained through frozen embryo transfer(fet)

Conditions: Infertilities; Embryo Transfer

Summary: in pregnancies achieved through programmed frozen embryo transfer cycle (pc-fet) and modified natural frozen embryo transfer (mnc-fet), to determine whether there are differences in endothelial and placental function, maternal cardiovascular function, fetal growth and fetal cardiovascular and cerebral programming and to assess whether there is an association between these differences and the plasma concentrations of the main secretion products of the corpus luteum (cl) with vasoactive and angiogenic action.


Eligibility criteria:
inclusion criteria: * female patients 18- 37 years old (both included) at the time of oocyte retrieval and less than 41 years of age at the time of embryo transfer. * regular menstrual cycles between 24 and 35 days. * availability of cryopreserved blastocysts from own gametes * indication for single embryo transfer. * patients who will be included in the luti study are candidates for either of the two procedures under study, and will have no contraindications for either procedure. exclusion criteria: * recurrent pregnancy loss (3 or more). * recurrent implantation failure in previous ivf treatments (3 or more unsuccessful embryo transfers). . * diagnosis of polycystic ovarian syndrome, diabetes mellitus, chronic arterial hypertension, maternal heart disease and autoimmune diseases (systemic lupus erythematosus (sle) or antiphospholipid syndrome (aps)). * active treatment with aspirin, heparin or other anticoagulant therapy, antihypertensives or other drugs used to treat circulation or coagulation disorders . * indication for pgt (preimplantation genetic testing). * multiple pregnancy.
evaluation of the aivarix in detecting signs c 1-2 classes of cvd

Conditions: Chronic Venous Disease; CVD

Summary: this study is a multicenter observational study, which is carried out in frame of routine clinical practice in russia. the program will include patients suggestive to chronic venous diseases (cvds) including but not limited to those with c1 and c2 classes by ceap classification, who will be seeking professional phlebologists' consultation. study conduction is scheduled in russia in 2022-2023. the planned number of patients is 414

the main goal of this study is to describe the aivarix app accuracy in detecting c1 and c2 classes by ceap classification of chronic venous disease (cvd) in patients who are consulted by phlebologists on symptoms and signs suggestive to cvd. at single visit, investigating physicians (phlebologists) will be assessing and collecting parameters of interest which they should input in ecrf. following data will be collected at the visit: a signed consent form from a patient, demographic characteristics (age, sex), eligibility of a patient to the inclusion/ non-inclusion criteria, 1 (one) image of skin area of interest, conclusion on presence or absence of cvd or any other pathologic condition(s) made as a result of objective/ instrumental examination. in case there will be any information related to safety of a servier drug provided, investigating physician will also collect the information and fill in the pv form (appendix 1).

Eligibility criteria:
inclusion criteria: * age over 18 years * written informed consent is provided * symptoms and signs of cvd or any other skin pathologic condition (s) of lower extremities for which a patient seeks for phlebologist's consultation * ability to fulfil the technical requirements for smartphones/ images exclusion criteria: * patients with mental/ psychiatric disabilities who are not able to understand objectives of the study and therefore provide a signed consent to participate in the study. * patient's decision to withdraw his/her consent to participate in the study at any moment of the study conduction
the italian coronary artery aneurysm and ectasia in patients with acute coronary syndrome

Conditions: Acute Coronary Syndrome; Angiographic Evidence if Coronary Aneurysms; Ectasia

Summary: the itaca study is a prospective, observational no profit registry enrolling patients with acute coronary syndrome and angiographic evidence of coronary aneurysms and/or ectasia.

the itaca study is aimed at evaluating short and long term outcomes in patients with acute coronary sindrome and angiographic evidence of coronary aneurysm and/or actasia. data regarding safety and effectiveness of invasive and pharmacological treatment strategies will be also collected.

Eligibility criteria:
inclusion criteria: * signature of informed consent; * patients aged ≥18 years; * diagnosis of acs (st-elevation myocardial infarction, non st-elevation myocardial infarction, unstable angina), in accordance with the definition provided in the latest guidelines; * diagnosis of ectasia or coronary aneurysm according to the definitions contained in this protocol, either in the culprit vessel of the sca than in another vessel. coronary pseudoaneurysms are excluded. exclusion criteria: * impossibility or unwillingness to provide signed informed consent; * contraindications to dual antiplatelet therapy; * contraindications to anticoagulant therapy; * active bleeding or severe anemia (hb \<6 g / dl); * life expectancy \<12 months; * female patients with potential pregnancy;

Keywords: aute coronary syndrome coronary artery artery ectasia
influence of regular physical activity on sleep in patients with copd and idiopathic lung fibrosis

Conditions: Pulmonary Disease, Chronic Obstructive; Fibrosis, Pulmonary

Summary: the study looked at whether regular physical activity can influence sleep duration, sleep quality and/or anxiety in patients with chronic obstructive pulmonary disease (copd) and idiopathic pulmonary fibrosis (ipf). the link between exercise and sleep has already been observed in the literature, but the impact of exercise on sleep is poorly understood. the question is how important is the influence of regular physical activity on sleep, anxiety and depression in patients with copd or ipf.

patients will be selected in two ways: 1. intervention group: patients with copd or idiopathic fibrosis following rehabilitation program in our center, who meet the inclusion criteria will be invited to participate in the survey and answer the questionnaires during the first week and again eight weeks after the start of the rehabilitation program. 2. control group: patients with copd or idiopathic fibrosis who do not perform any regular physical activity will be invited to participate in the survey and answer the questionnaires. the questionnaires are validated and the time allowed for completion is 45 minutes. the questionnaires will assess sleep quality, anxiety and symptoms of depression.

Eligibility criteria:
inclusion criteria: * patients with copd. * patients with idiopathic pulmonary fibrosis. * patients who can read and write in french. * patients who agree to participate in research and sign the informed consent form. * patients who participated of our rehabilitation program or patients who do not do any regular exercise activity. exclusion criteria: * regular use of continuous positive airway pressure devices (cpap)
prospective observational cohort study of critically ill patients with covid-19 in sweden

Conditions: Covid-19; Critical Illness

Summary: the study will prospectively collect data from patients with covid-19 admitted to the västerås intensive care unit, västerås hospital. demographic, clinical, radiographic and laboratory characteristics will be recorded. analysis of data to identify predictors of disease severity, mortality and treatment response.


Eligibility criteria:
inclusion criteria: * patients admitted to the intensive care unit with biological samples positive for sars-cov-2. * patients admitted to the intensive care unit with one or more negative tests but with clinical and radiological characteristics highly suggestive of sars-cov-2 and thus considered positive for the disease. exclusion criteria: * none.
ai derived biomarker to select neoadjuvant treatment for borderline resectable pancreatic ductal adenocarcinoma

Conditions: Pancreatic Ductal Adenocarcinoma

Summary: to collect samples and information from patients who will be undergoing standard of care neoadjuvant treatment with either folfirinox or gemcitabine + nab-paclitaxel. the information collected will be used to determine if there are any "biomarkers" in your blood or tumor tissue that, when compared to your response to the neoadjuvant treatment, could be used to choose the best treatment option for future patients with similar biomarkers.


Eligibility criteria:
inclusion criteria: * have histologically or cytologically confirmed pdac that is borderline resectable (br) (cohort a) or have histologically or cytologically confirmed pdac that is resectable (cohort b) using the national comprehensive cancer network criteria \[35\]. * availability of archival tumor tissue (diagnostic for pdac) required * have a documented ecog performance status of ≤ 1 * participant must understand the investigational nature of this study and sign an independent ethics committee/institutional review board approved written informed consent form (icf) prior to receiving any study related procedure. exclusion criteria: * has received prior systemic treatment (standard of care or experimental) for pdac * participant has a concurrent malignancy requiring active treatment during the study.
sedation and psychopharmacology in critical care

Conditions: Sedation; Mechanical Ventilation; Depression; Post-traumatic Stress Disorder; Quality of Life

Summary: certain methods of sedation increase the duration of respiratory failure. two strategies, a nursing- implemented sedation algorithm and daily interruption of sedatives, decrease length of mechanical ventilation compared to "conventional care" but have not been compared to each other. the reason certain methods of sedation lead to prolonged respiratory failure is unknown but may be related to altered pharmacokinetics and dynamics that are unique to critically ill patients. critically ill patients receive substantial doses of sedatives over prolonged periods. the impact of these management strategies on short- and long-term psychiatric complications are unknown. the study seeks to test the central hypothesis that sedation practices impact strongly on outcome of respiratory failure and psychiatric complications. the three specific aims are (1) to compare two sedation strategies (protocol directed sedation and daily interruption of sedatives), (2) to examine the prevalence of psychiatric complications, and (3) to compute the pharmacokinetics of commonly used sedatives and narcotics. these aims will be achieved by enrolling critically ill patients in a prospective randomized trial comparing the above mentioned sedation strategies, and assessing sedation level as well as delirium throughout the duration of respiratory failure. sedative plasma levels will be measured, and pharmacokinetics computed. psychiatric morbidity will be assessed by administration of validated questionnaires.


Eligibility criteria:
inclusion criteria: patients aged 18 and older undergoing mechanical ventilation via naso- or orotracheal tube - exclusion criteria: age less than 18, tracheotomy, severe dementia or mental retardation, severe neuromuscular disease or neuromuscular blockade use, institution of mechanical ventilation at another hospital -