feasibility of valve-in-root transcatheter aortic valve implantation in 363 patients after aortic root replacement and repair

Conditions: Aortic Valve Disease Mixed; Transcatheter Aortic Valve Replacement

Summary: biological replacement of the aortic valve in the sense of a complete root replacement is the therapy for a dilatation or aneurysm of the ascending aorta, which also involves the aortic valve. in some patients, the aortic valve can be preserved, which means that only reconstruction is necessary instead of a complete replacement of the root. for a root replacement or root reconstruction, both coronary arteries must be prepared at their origin from the aorta and reimplanted into a tubular prosthesis. it is known that biological aortic valve prostheses have a lifespan of between 10-20 years depending on the type and design of the valve and that the first degenerative symptoms become visible after 10-12 years. this is particularly relevant for patients who have their initial operation at a younger age and require a follow-up procedure if the valve degenerates at an older age. the minimally invasive implantation of transcatheter valves has proven to be a successful method, avoiding a second operation with an increased risk of mortality. the so-called valve-in-valve procedures are carried out particularly in older patients and are now standard in modern valve treatment. the feasibility of a valve-in-valve in the aortic position requires certain anatomical conditions, which can be influenced by the surgeon's implantation technique in the case of additional root replacement. in particular, there is a risk of coronary artery occlusion when implanting the transcatheter valve, which is increased if the coronary artery branches are located below the valve level. in addition, the selection of the prosthesis size is an important parameter for subsequently implanting a suitably large transcatheter valve. the aim of this study is to use postoperative computer tomography of patients after root replacement/reconstruction to measure the anatomical parameters that describe a possible implantation of a transcatheter valve in the event of degeneration of the initial valve. this simultaneously shows the quality of the root replacement/reconstruction with regard to a plannable follow-up procedure and can also show for the future how the surgical technique could be modified to make a minimally invasive follow-up intervention available to more patients. this study aims to answer the question of whether the patients who were treated with biological root replacement or reconstruction in the years 2012-2022 for aortic valve failure are anatomically suitable for valve-in-valve therapy based on the postoperative computed tomography measurements of the aortic root. in addition, the measurements provide a surgical answer to the question of whether relevant parameters such as the distance between the coronary arteries were sufficiently taken into account during the initial operation or whether an improvement should be made in the future while adhering to the anatomically important parameters during the initial procedure.


Eligibility criteria:
inclusion criteria: * all patients over 18 years after biological aortic root replacement or repair * postoperative ecg-gated ct-angiography scan exclusion criteria: * mechanical aortic root replacements (not suitable for valve-in-root treatment) * missing postoperative ecg-gated ct-angiography scan

Keywords: valve-in-root aortic valve replacement transcatheter aortic valve replacement root replacement valve-sparing aortic root replacement