Kornimate/medical-research-clean huggingface dataset:
self-stigma of mental and physical health

Conditions: Mental Disorder; Organic Disease

Summary: people with mental disorders often suffer from self-stigmatization. self-stigma is associated with several negative outcomes such as low quality of life, lower rates of help-seeking as well as poorer treatment adherence. however, a lot of questionnaires only focus on specific mental disorders. there is no valid measurement which can be used for all kinds of mental disorders. furthermore, much less is known about self-stigma in people with organic diseases. only little attention has been given to those who may experience self-stigma because of their physical condition. a main reason for this may be the lack of a valid measurement of self-stigma among people with physical health issues. therefore, the aim of this study is to develop and validate a self-report scale which is capable to do both - measuring self-stigma among people with all mental disorders and among people with physical health issues.

items are derived from the stereotype content model (scm) and the behaviors from intergroup affect and stereotypes (bias) map. psychometric evaluation includes testing the reliability (intern consistency, test-retest reliability) and validity (exploratory and confirmatory factor analysis, construct validity incl. convergent and discriminant validity, criterion-related validity). participants take part in an online survey. they answer general questions about their mental and physical health condition and complete measurements of quality of life, mental health, depression, public stigma, expected stigma, self-stigma, intention to seek help and actual help seeking (behavior).

Eligibility criteria:
inclusion criteria: * minimum age: 18 * fluent in german language exclusion criteria: * acute psychosis * suicidal ideation

Keywords: self-stigma mental health physical health questionnaire
engagement and clinical impact of the teleo virtual therapy platform in clinical settings

Conditions: Anxiety Disorders; Mood Disorders

Summary: the research study will examine engagement in telehealth for children undergoing psychotherapy. specifically, the pilot trial will examine examine patient engagement in teleo, a virtual therapy platform specifically designed for psychotherapy with youth, as compared to standard video conferencing.

the research study will examine engagement in telehealth for children undergoing psychotherapy. the study in phase i entails a pilot randomized trial with a goal to enroll 42 families, examining patient engagement in teleo, a virtual therapy platform specifically designed for psychotherapy with youth, as compared to standard video conferencing. engagement will be assessed using well-established measures - prime-o (modified) video coding, mtt-y/mttcg and attendance data (sessions 1-4). clinicians in the study will deliver therapy to clients for 4 sessions, providing opportunity to measure temporal sustainment of any engagement differences.

Eligibility criteria:
inclusion criteria: * patient ages 5-14 * receiving psychotherapy with a licensed professional on the teleo platform * likely have at least 12 sessions remaining. * rcads score \> 65 exclusion criteria: * not under treatment with provider using teleo platform
evaluation of the providence nighttime brace for the treatment of adolescence idiopathic scoliosis

Conditions: Adolescence Idiopathic Scoliosis

Summary: a multicenter, prospective, non-randomized, single-arm observational study evaluating the providence nighttime bracing system in patients diagnosed with adolescence idiopathic scoliosis.

this study is designed as a multicenter, prospective, non-randomized, single arm observational study. a temperature probe and data logger will be attached to the providence brace to monitor patient compliance wear time. subjects will be blinded to temperature sensor readings to maximize objectivity of brace wear.

Eligibility criteria:
inclusion criteria: * subject/guardian is able to provide informed consent and must sign the institutional review board approved informed consent form; * clinical/radiographic diagnosis of adolescence idiopathic scoliosis; * male/female; * skeletally immature (risser grade 0, 1, or 2); * cobb angle between 25-40 degrees; * pre-menarchal or post-menarchal by no more than 1 year at the time of diagnosis; * curve apex caudal to t6 vertebrae; * physical and mental ability to adhere to bracing protocol; * have agreed to refuse participation in another clinical trial for the duration of the study. exclusion criteria: * history of previous surgical intervention or other invasive treatment for ais; * history of orthotic treatment or other brace wear for the treatment of ais; * diagnosis of other musculoskeletal or developmental illness that might be responsible for the spinal curvature; * tumor or malignant tumor in the spine; * inability to communicate clearly in the english language; * subjects with a risser score ≥ 3; * plans to relocate within the next 2 years; * any subject the principle investigator deems as an unfit candidate.

Keywords: adolescence idiopathic scoliosis nighttime bracing providence
treatment of patients with trophic ulcers using mesenchymal stem cells

Conditions: Trophic Ulcer

Summary: treatment of patients with trophic ulcers using injection of autologous adipose-derived mesenchymal stem cells around and inside the wound

during the implementation of the project, it was planned to develop a method for the treatment of trophic ulcers using injection of autologous adipose-derived mesenchymal stem cells in the wound. the positive outlook for the effectiveness of mscs is due to the following: * the ability of mscs to stimulate tissue regeneration * positive results of preclinical studies of the method of treatment of trophic ulcers in animals (rats). in study were included 18 patients (28 trophic ulcers treated). mscs will be isolated from adipose tissue, cultured and then transplanted back to the wound. from 1 to 10 million mscs in 4 ml were injected depending on the area of the wound. follow up patients monitoring will occur at 1，2 and 3, 6, 12, 22 months after injection.

Eligibility criteria:
inclusion criteria: * trophic ulcers exclusion criteria: * diagnosed cancer * acute and chronic infectious diseases: hiv, viral hepatitis, tuberculosis * mental disorders * pregnancy

Keywords: trophic ulcer mesenchymal stem cells
neurogenic inflammation in diabetes

Conditions: Diabetes Mellitus; Polyneuropathies; Arthropathy, Neurogenic

Summary: polyneuropathy is a complication of diabetes mellitus which leads to decreased sensation in arms and legs. this in turn can lead to the development of (infected) foot ulcers. charcot's disease can also be a consequence of polyneuropathy. patients with charcot's disease suddenly develop a red, warm and swollen foot, like an infection. charcot's disease leads to foot fractures. after these fractures have healed, the shape of the foot can be dramatically altered. this altered shape of the foot increases the risk of developing foot ulcers. nerves are important in regulating the inflammatory response. this study aims to investigate whether the inflammatory response is different in patients with polyneuropathy with and without a history of charcot's disease.


Eligibility criteria:
inclusion criteria: * patients with type 2 diabetes with and without polyneuropathy. * patients with type 2 diabetes with a history of charcot's disease. * healthy controls. * signed informed consent. exclusion criteria: * peripheral arterial disease: toe pressure \< 70 mm hg and/or transcutaneous oxygen tension \< 40 mm hg and/or claudication. * renal insufficiency: mdrd creatinin clearance \< 30 ml/min. * systemic disease such as vasculitis or rheumatoid arthritis. * malignancy. * (diabetic) foot ulcer. * gout. * bacterial infection of an extremity. * skin condition of the dorsal aspect of the foot or the medial side of the upper arm. * bleeding disorder such as hemophilia. * use of medication for asthma. * impaired immunity such as in hiv/aids. * capillary blood glucose \ 20 mmol/l at the time of the study. * peripheral oedema. * vaccination in the two months prior to study inclusion. * chemotherapy or radiation therapy in the twelve months prior to study inclusion. * surgery in the two months prior to study inclusion. * previous adverse reaction to candida albicans antigen. * acute infection at the time of the study or in the month prior to study inclusion. * transfusion in the two months prior to study inclusion. * use of immunosuppressants in the two months prior to study inclusion. * pregnancy or breastfeeding.
orthotic treatment of diabetic foot ulcers

Conditions: Diabetic Foot Ulcer

Summary: the united states department of veterans affairs spends an estimated $1.5 billion a year on healthcare for patients with diabetes. the prevalence and complications of diabetes increase with age. therefore, with the aging of the us and veteran populations, there is an expectation of increased healthcare costs associated with treating diabetes and the associated complications of this disorder. one common complication is the diabetic foot ulcer. diabetic foot ulcers are expensive to treat, can take a long time to heal and result in a decrease in patient quality of life. patients remain susceptible to developing more foot ulcers over time. the goal of this project is to reduce the time it takes to heal a diabetic foot ulcer, increase the time between episodes of ulceration and improve the quality of life for diabetic foot ulcer patients.


Eligibility criteria:
inclusion criteria: * veteran patients prescribed an orthotic walking boot for treatment of their diabetic foot ulcer will be eligible to participate in the study. exclusion criteria: * veteran patients with amputation proximal to the tarsometatarsal joint, with a meggitt-wagner score of 4 or more, with severe infection, with non-ambulatory status or without palpable pedal pulse will be excluded * all patients will be screened for severe cognitive impairment with the 15 point brief interview for mental status (bims) * scores between 12 and 8 will indicate need for extra efforts to support comprehension of instructions, and patients with scores of 7 or less will be excluded
maternal counseling for preterm deliveries, assessing an effective method of counseling

Conditions: Pregnancy Preterm; Counseling

Summary: providing verbal counseling supplemented with both written and pictorial information then verbal counseling alone is a more effective method of counseling parents with threatened preterm delivery

progress in the frontiers of neonatology has continually pushed back the limit of viability and significantly improved the survival of extremely preterm infants. an important component of medical management before a preterm delivery is counseling the parents about probabilities of survival and long term complications. hypothesis: preterm counseling is more effective when parents receive verbal counseling supplemented with written and pictorial information then verbal counseling alone. methodology: there will be two groups of study (verbal, pictorial and written vs verbal alone). all patients admitted to the l and d department of stroger hospital between 23 to 34 weeks of gestation with threatened premature delivery will be enrolled in the study. they will be randomly assigned to 1 of 2 groups. after counseling, parents will be asked to complete a 32 point questionnaire to check their knowledge of outcomes of prematurity. to reach statistically significant results, the investigators will need 40 patients in each group. the study will be done over a period of one year

Eligibility criteria:
inclusion criteria: * pregnant women between 23 to 34 weeks gestation assessed by obstetrician to need counseling exclusion criteria: * pregnancies with known life threatening defects considered as non compatible with life. * mothers previously admitted and counseled will also be excluded
registry and survey of women with pregnancy related cardiomyopathy

Conditions: Cardiomyopathy; Pregnancy-Associated Cardiomyopathy; Heart Failure

Summary: the goal of this study is to better characterize peripartum cardiomyoapthy or pregnancy-related cardiomyopathy by enrolling as many ppcm survivors as possible using both direct and web-based methods of recritment. patients will anser a questionnaire regarding the onset, progression, treatment and follow-up of their diagnosis as well as the psychosocial aspects of ppcm.

the design of our study will utilize web-based recruitment methods with internet-based support groups for ppcm e.g. www.amothersheart.org (www.amothersheart.org/index.html). the directors of these websites will facilitate contact between our research staff and the several hundred members of these web sites. an introductory letter will be posted on the website introducing the cardiovascular research team and describing the purpose, basic methods, and goals of our study. website members who desire to participate can respond to a dedicated e-mail address we have set up and provide contact information so that we may get informed consent via telephone or mailed written consent. a telephone number will also be provided for participants so that they may call with questions regarding the study. patients will then receive a questionnaire addressing our study goals. questions will focus on obtaining family and social history, characterizing presenting symptoms, initial management, and clinical course following delivery of the fetus including extent of cardiovascular follow-up, date of echocardiograms performed, medications, and psychosocial support, if provided.

Eligibility criteria:
inclusion criteria: patients will be eligible for inclusion if diagnosed with ppcm after january 1, 1994. patients must be above the age of 18 years old with no prior cardiac history and no history of chronic drug or alcohol abuse. diagnosis of ppcm must have been made prior after the 28th week of gestation and up to 6 months postpartum. patients must have echocardiographic data confirming left ventricular systolic dysfunction by either depressed shortening fraction or depressed ejection fraction. exclusion criteria: patients with an identifiable etiology for their heart failure will be excluded.

Keywords: heart failure peripartum cardiomyopathy pregnancy-associated cardiomyopathy pregnancy complications nonischemic cardiomyopathy
geriatric determinants of general repercussion of radiotherapy for patient over 75 years with prostate cancer

Conditions: Prostate Cancer

Summary: the investigators propose to carry out a prospective analysis of physical impact, psychological, cognitive and social of radiotherapy in all patients over 75 years bearer of localized prostate cancer with an indication of curative radiotherapy. this standardized geriatric assessment will collect social information, functional, sensory, cognitive, emotional, motor, nutritional, and medical related to comorbidities . the quality of life of patients will be evaluated by the qlq c30 (quality of life questionnaire) european organisation for research and treatment of cancer (eortc) before starting treatment, at the end of radiotherapy (2 months) and at 6 months. this short follow-up period seems appropriate in this elderly population and will allow an answer within 2 years to the problem raised in clinical practice.


Eligibility criteria:
inclusion criteria: 1. man with a histologically proven prostate cancer 2. indication of a curative intent radiotherapy 3. age ≥ 75 years 4. patient who signed an informed consent exclusion criteria: 1. patient with metastatic prostate cancer 2. patient unable to submit to monitoring of the protocol for social, geographical or family reasons 3. a person who is not affiliated to a social security scheme or of such a scheme 4. patient under trusteeship
a study of treprostinil to treat interstitial lung disease pulmonary hypertension

Conditions: Pulmonary Arterial Hypertension; Interstitial Lung Disease; Healthy Adults

Summary: the purpose of this research study is to find out more about the drug treprostinil via inhaler and the mechanisms of why patients with pulmonary arterial hypertension related to interstitial lung disease (pah-ild) have limitations during exercise. the investigator is studying treprostinil's effect on patients with pah-ild during exercise and its effect on their quality of life after using it for 3 months.


Eligibility criteria:
inclusion criteria: * patients with pulmonary arterial hypertension due to interstitial lung disease (ild-pah) being considered for inhaled treprostinil * resting right heart catheterization with mean pulmonary artery pressure \>20 mmhg and pvr\> 3 wood units * healthy volunteers will have no known lung disease, heart failure, muscular disease or pulmonary hypertension, no bleeding abnormalities, and have the ability to exercise. exclusion criteria: * inability to exercise * females who are pregnant
drug interaction study between azd3480 and warfarin

Conditions: Alzheimer's Disease

Summary: the purpose of the study is to evaluate if azd3480 and warfarin interact with each other or not, i.e. show the same or altered plasma concentration profiles when co-administered compared to administered alone.


Eligibility criteria:
inclusion criteria: * provision of signed written informed consent * clinically normal physical findings and laboratory values exclusion criteria: * clinically significant illness or clinically relevant trauma within three weeks before the first dose * history of clinically significant disease * use of prescribed medication during the 2 weeks before administration of the first dose of investigational product

Keywords: azd3480 warfarin drug interaction
karydakis procedure versus excision with healing by secondary intention (ehsi) in sacrococcygeal pilonidal sinus

Conditions: Pilonidal Sinus; Pilonidal Cyst

Summary: recurrence, complications, work-off date, healing time and patients willingness in karydakis technique for treatment of sacrococcygeal pilonidal sinus versus healing by secondary intention (ehsi) technique in imam khomeini hospital from 2008 to 2011


Eligibility criteria:
inclusion criteria: all types of pilonidal sinus or cyst exclusion criteria: no exclusion criteria

Keywords: pilonidal sinus karydakis laying open
the effect of acute transcranial bright light on anxiety symptoms

Conditions: Anxiety

Summary: the purpose of this study is to determine if transcranially administered bright light has acute effect on anxiety symptoms.

subjects (n=30) with anxiety symptoms will be recruited into the study. to be included into the study, subjects have to get at least seven points in bai(becks anxiety inventory). at the beginning of the study subject will be randomly assigned to 12 minutes of acute transcranial bright light or placebo exposure group. anxiety symptoms will be measured using spielberger state-trait anxiety inventory (stai, form y1)self-rating questionnaire just before and 10 and 110 minutes after the experiment.

Eligibility criteria:
inclusion criteria: * subject can read and understand the study protocol * the written informed consent is obtained from subject * subject's bai total score \>= 7 exclusion criteria: * subject has a lifetime psychotic disorder * subject abuses substance or has a dependence * subject has had suicidal idealization during the past month * subject use psychotropic medications * subject has unstable somatic disease * subject has used bright-light therapy for the current episode * subject is pregnant * subject is a relative of a member of research team * subject has used transcranial light treatment
effect of cer-001 on atherosclerosis in acute coronary syndrome (acs) patients - efficacy and safety: the chi square trial

Conditions: Acute Coronary Syndrome

Summary: cardiovascular disease remains the most pressing healthcare issue for developed countries and is becoming so for developing countries. there are a number of chronic therapies available for long-term management of risk. short term therapies for subjects with an acute event, such as an episode of acute coronary syndrome (acs), are focused on reperfusion and removing thrombus but most subsequent events are caused by atherosclerotic plaque rupture at a different site. there are no approved therapies that can rapidly reduce the burden of unstable, inflamed plaque in the overall coronary vascular bed. hdl has multiple actions that could lead to atherosclerotic plaque stabilization, such as rapid removal of large quantities of cholesterol from the vasculature, improvement in endothelial function, protection against oxidative damage and reduction in inflammation. this study will assess the effects of cer-001, an apoa-i-based hdl mimetic, on indices of atherosclerotic plaque progression and regression as assessed by intravascular ultrasound (ivus) measurements in patients with (acs).


Eligibility criteria:
inclusion criteria: * male or female less than 75 years of age * acute coronary syndrome (acute chest pain and a diagnosis of st segment elevation myocardial infarction, non-st elevation myocardial infarction or unstable angina) * angiographic evidence of coronary artery disease with suitable "target" coronary artery for ivus evaluation exclusion criteria: * females of child-bearing potential * weight \>120 kg * angiographic evidence of \>50% stenosis of the left main artery * uncontrolled diabetes (hba1c\>10%) * hypertriglyceridemia (\>500 mg/dl) * congestive heart failure (nyha class iii or iv) * ejection fraction \<35% * uncontrolled hypertension (sbp \>180 mm hg) * known major hematologic, renal, hepatic, metabolic, gastrointestinal or endocrine dysfunction

Keywords: acute coronary syndrome hdl mimetic apoa-i