Kornimate/medical-research-clean huggingface dataset:
effectiveness of a multimodal intervention with simulation for learning home health nursing care of patients with multimorbidity and heart failure

Conditions: Multimorbidity; Heart Failure

Summary: the goal of this clinical trial is to evaluate the efficacy of a multimodal intervention with high-fidelity simulations on home health nursing in improving the care of multipathological patients with heart failure in nursing students. the main questions it aims to answer are: * does using validated simulation scenarios on multipathological patients with heart failure improve care competencies in nursing students? * does knowledge of scientific evidence and healthcare protocols improve nursing students' performance in the simulator? researchers will compare a multimodal intervention with high-fidelity simulations on home health nursing to conventional intervention (theoretical teaching) to see if nursing students better learn competencies related to the care of patients with multimorbidity and heart failure during the home health nursing. participants will: * experience simulations on validated simulation scenarios on multipathological patients with heart failure (all participants). * reflect on the intervention performed on the simulator through individual and group debriefings (experimental group). * learn about the main scientific evidence and international and national protocols related to comorbidities and health failure (experimental group).


Eligibility criteria:
inclusion criteria: * nursing students enrolled in the subject "family and community nursing i". exclusion criteria: * lack of attendance since the beginning of the course. * failure to follow the instructions of the instructors during the course of the study. * voluntary withdrawal from the study during the study or declaring non-participation.

Keywords: high fidelity simulation training patient simulation home health nursing primary care nursing family nursing nursing education research students, nursing education, nursing
transversus thoracis muscle plane block for postoperative pain in adult cardiac surgery

Conditions: Postoperative Pain; Chest Pain; Coronary Artery Bypass; Sternotomy

Summary: inadequate pain control after coronary artery bypass graft surgery increases mortality and results in a higher incidence of persistent poststernotomy pain syndrome. our aim is to assess whether ultrasound-guided parasternal intercostal block (psib) or surgeon implied transversus thoracic muscle plane block (ttmpb) would improve the postoperative pain scores and decrease tramadol consumption better after coronary artery bypass graft surgery


Eligibility criteria:
inclusion criteria: * american society of anesthesiologists physical status ii-iii * elective coronary artery bypass graft surgery under general anesthesia exclusion criteria: * american society of anesthesiologists physical status iv * emergency surgery and redo surgery * low cardiac output syndrome, perioperative intra-aortic balloon pump support for any reason, bleeding disorder or abnormal coagulation profile, abnormal hepatic and renal parameters, uncontrolled diabetes mellitus, chronic obstructive pulmonary disease, atrial fibrillation on anticoagulation * allergy to any study drugs, local infection at the block site * opioid abuse

Keywords: adult cardiac surgery poststernotomy pain transversus thoracic muscle plane block parasternal intercostal block behavioral pain scale numeric rating scale
clinical evaluation of localized scalp thread embedding for male androgenetic alopecia

Conditions: Androgenetic Alopecia

Summary: this clinical study aims to evaluate a breakthrough treatment for hair loss (androgenetic alopecia, aga) using dissolvable threads placed under the scalp skin. the investigators hypothesize that these specially designed threads can improve hair growth, avoiding the need for invasive surgery. current aga treatments taken orally often have limitations, prompting researchers to explore localized approaches. while early studies show promise for localized scalp thread embedding, three key challenges remain: 1) no standardized way to measure effectiveness, 2) lack of objective biological markers to track progress, and 3) limited understanding of how exactly these treatments work. this study addresses these gaps through precise thread placement in balding areas, following international dermatology guidelines. using advanced measurement tools, the investigators will track changes in hair thickness (primary measure), blood flow patterns under the skin, and oil gland activity (secondary measures). by focusing on one key treatment factor, this research provides the first comprehensive evidence showing how this minimally invasive approach may slow or reverse aga progression.


Eligibility criteria:
inclusion criteria: * male sex * age 18-50 years * no clinically significant comorbidities * androgenetic alopecia (hamilton-norwood iii-v) * no systemic anti-hair loss therapy use within 3 months * no topical hair regrowth agent use within 3 months exclusion criteria: * active scalp infection * scalp psoriasis * scalp eczema * open scalp wounds * allergy to thread materials * uncontrolled diabetes mellitus * immunodeficiency disorders * non-compliance with follow-up visits * refusal to provide informed consent * investigator-deemed contraindications

Keywords: androgenetic alopecia interventional study non-pharmacological interventions
clinical study of external electrical stimulation for male incontinence

Conditions: Urinary Incontinence

Summary: the purpose of this research is to evaluate the effectiveness of the elidah neuromuscular stimulation treatment to reduce incontinence in men post-prostatectomy.


Eligibility criteria:
inclusion criteria: * scheduled for robotic-assisted laparoscopic prostatectomy * read and speak english * predominant sui of at least 1 pad/day exclusion criteria: * history or symptoms of urinary incontinence, urinary retention, extra-urethral incontinence, overflow incontinence * complete denervation of the pelvic floor * severe obesity as defined by bmi \&gt;= 40 * has undergone pre-op pelvic floor exercise strengthening * pelvic pain/painful bladder syndrome * implanted cardiac device, untreated cardiac arrhythmia or suffer from other heart problems. * history of epilepsy * underlying neurologic/neuromuscular disorder * metal implants in the abdomen or pelvic area * chronic coughing * impaired decision making, suicidal thoughts, or drug/alcohol dependence * uncontrolled intercurrent illness that would limit compliance with study requirements * lacks capacity to adhere with study requirements * lacks capacity to consent for themselves.

Keywords: male men prostatetectomy incontinence electrical stimulation
breast cancer registry - national university health system, singapore

Conditions: Breast Cancer

Summary: the breast cancer registry aims to collect clinical data of all breast cancer patients diagnosed and/or treated in the national university hospital, with the goal of understanding risk factors, presenting symptoms, diagnosis, treatment, and outcome data of breast cancer in singapore. this information will contribute to improving management of breast cancer patients.


Eligibility criteria:
inclusion criteria: - all breast cancer patients who were diagnosed or managed in nuh. exclusion criteria: - non breast cancer patients.

Keywords: all breast cancer patients who were diagnosed or managed in nuh will be included into this registry
evaluation of interests of fit therapy on diabetics children insulin-dependent

Conditions: Diabetes Insulin Dependent

Summary: evaluation of interests of the functional insulin therapy (fit therapy) on metabolic control, hypoglycemia prevention and life quality of diabetics children insulin-dependent treated with insulin pump.

open multicenter randomized study of one year, evaluating two groups of 44 children with diabetes mellitus (diabetes over 1 year) treated with insulin pump, one group by traditional way (fixed doses of insulin and meals providing stable quantities complex carbohydrates) and the other group by fit therapy.

Eligibility criteria:
inclusion criteria: * aged 1-17 years * diabetic for at least 1 year * whose hba1c is between 7.6 and 10% (7.6% \<hba1c \<10%) * treated with insulin pump * agreeing to perform at least three blood glucose/day * willing to follow the treatment with functional insulin therapy if necessary exclusion criteria: * ages \ 17 years * duration of diabetes \<1 year * hba1c \ 10% * treatment-by multiple injections * mental disability * refusal to adhere to the constraints of the study * language barrier, preventing any understanding or cooperation * eating behavior-type anorexia or bulimia * pregnancy * use of alcohol or drugs * severe chronic or genetic pathology other than diabetes * participation in another clinical study or refusal to participate in the study

Keywords: fit therapy diabetes mellitus insulin pump pediatric
a multi-center protocol for obtaining and storing human samples for immediate or future microbial, immune, or host microbe scientific study

Conditions: Infection

Summary: the intent of this protocol is to salvage human-related material that is normally destined for destruction, so it can be used in infection-related scientific studies.

this clinical material can be studied in order to better understand the molecular, cellular, or ecological components of the infected or potentially infected tissue or device. these studies may be able to provide important insights into the keys of chronic infections, complex infections, medical biofilms, pathogen ecology, and healing.

Eligibility criteria:
inclusion criteria: * the subject must be 18 years of age or older. * the subject must be mentally competent as determined by the investigator. exclusion criteria: * the subject may not be currently incarcerated. * the subject may not be knowingly pregnant. * the subject may not be institutionalized. * the subject may not be an employee or student of the investigator or sponsor.

Keywords: wound debridement removed orthopedic implants removed catheters or shunts excised tonsils amputated tissue sputum, stool or other excretions.
clinics and epidemiology of pituitary diseases in modena area population

Conditions: Pituitary

Summary: this is an observational, longitudinal, single-center study. the study is divided in two phases: * first phase (retrospective): registration of all patients affected by pituitary disorders followed at the unit of endocrinology of azienda ospedaliero-universitaria of modena * second phase (prospective): enrollment of all patients affected by pituitary disorders who attend the unit of endocrinology of the azienda ospedaliero-universitaria of modena. an anonymized database will be created to collect the data of the patients. in particular, the data collected for each patient will include: personal data, data relating to pituitary pathology, symptoms at diagnosis, physical examination, radiological imaging, visual field data, data on surgical intervention, data on histological examination, biohumoral examinations, hormone tests, densitometric data, data on replacement therapies, medical therapies or other pharmacological therapies, data on comorbidities.


Eligibility criteria:
inclusion criteria: * subjects affected by pituitary disorders who attended unit of endocrinology of azienza ospedaliero-universitaria di modena exclusion criteria: * subjects under 18 years old
a dose-response study of the cognitive and physiological effects of tdcs to the dlpfc

Conditions: Attention Deficit Hyperactivity Disorder

Summary: to determine the cognitive and neurophysiological dose-response relationships of anodal tdcs to the left dlpfc as a function of absolute current intensity, individualized e-field intensity, and stimulation duration.

to determine the cognitive and neurophysiological dose-response relationships of anodal tdcs to the left dlpfc as a function of absolute current intensity, individualized e-field intensity, and stimulation duration.

Eligibility criteria:
inclusion criteria (patients) 1. male and female outpatients 18-55 years of age 2. a diagnosis of add/adhd or meeting the diagnostic and statistical manual of mental disorders, fifth edition (dsm-5) criteria. 3. patient will be either off stimulant medications or, if undergoing treatment with stimulants, will be asked to discontinue two days prior to the experiment, under physician-guided protocol, and allowed to resume afterwards. subjects may resume stimulant use between the two study visits so long as they discontinue use two days prior to the second study visit. if fatigue is problematic in subjects discontinuing medication, they will be allowed to continue with the study if they are able to follow the suggested taper plan (50% of the dose day one, 25% dose day 2, stop day of visit (day 3)). 4. if on non-stimulant medications, dose must have been stable for at least 4 weeks. exclusion criteria (patients) 1. contraindication to tdcs: history or epilepsy, metallic implants in the head and neck, brain stimulators, vagus nerve stimulators, vp shunt, pacemakers, pregnancy. 2. active substance dependence (except for tobacco). 3. pregnant or nursing females. 4. inability to participate in testing procedures. inclusion criteria (healthy control) 1. male and female outpatients 18-55 years of age exclusion criteria (healthy control) 1. diagnosis of psychiatric of neurological disorder 2. ongoing treatment with any psychotropic medications. 3. contraindication to tdcs: history or epilepsy, metallic implants in the head and neck, brain stimulators, vagus nerve stimulators, vp shunt, pacemakers, pregnancy. 4. active substance dependence (except for tobacco). 5. pregnant or nursing females. 6. inability to participate in testing procedures.

Keywords: transcranial direct current stimulation
a relative bioavailability study of valcyte (valganciclovir) in lung transplant recipients with or without cystic fibrosis.

Conditions: Cytomegalovirus Infections

Summary: this study will assess the relative bioavailability of ganciclovir from the pro-drug valganciclovir in lung transplant recipients with or without cystic fibrosis. each patient will receive 900mg valganciclovir daily for the period specified at their center, starting as soon as possible after the transplant. pharmacokinetic assessments will be made provided that steady-state kinetics of ganciclovir and immunosuppressive drugs have been obtained (\>=4 days of drug therapy). blood samples for pharmacokinetic analysis will be taken up to 24h post-dose on one occasion. the anticipated time on study treatment is 3-12 months, and the target sample size is \<100 individuals.


Eligibility criteria:
inclusion criteria: * male or female patients, \>=14 years of age; * first lung or heart-lung transplant recipient; * at risk of cmv disease (d+r-,d+r+ or d-r+); * estimated creatinine clearance \>=60ml/min; * stable immunosuppressive and 900mg valcyte dosing regimens (\>=4 days) prior to pharmacokinetic assessments. exclusion criteria: * history of any adverse reaction to acyclovir, valacyclovir, ganciclovir or valganciclovir; * evidence of graft rejection; * patient has received anti-cmv prophylaxis with a treatment other than cytogam, ganciclovir or valganciclovir between transplant and screening.
propranolol plus ligation reduces recurrence of esophageal varices?

Conditions: CIRRHOSIS; ESOPHAGEAL VARICES

Summary: this prospective randomized controlled trial will compare endoscopic band ligation (ebl) with propranolol and ebl alone in primary prophylaxis of variceal bleeding among cirrhotic patients with high-risk varices.

background and aims bleeding from esophagogastric varices (ev) is a major complication of portal hypertension. beta-blockers are a well-established cornerstone of portal hypertension treatment. band ligation is the best endoscopic treatment to prevent ev bleeding. the exact benefit of beta-blocker association to band ligation remains to be defined, especially for primary prophylaxis. this prospective randomized controlled trial will compare ebl with propranolol and ebl alone in primary prophylaxis of variceal bleeding among cirrhotic patients with high-risk varices. patients and methods: the patients with high-risk varices will be randomly allocated to ebl plus propranolol (group i) or ebl alone (group ii). ebl will be performed at 3-week interval till obliteration of varices. in group i, incremental dosage of propranolol (sufficient to reduce heart rate to 55 beats/min or 25% reduction from baseline) will be administered and will be continued after obliteration of varices until the end of the study. the follow-up of patients will be 2 years. the primary outcome of this study will be ev recurrence during two years of follow-up. the secondary outcomes will be ev eradication, bleeding before eradication, mortality and complications during the same follow-up.

Eligibility criteria:
inclusion criteria: * liver cirrhosis with esophageal varices * age between 18 and 78 years * accept to participate exclusion criteria: * portal hypertension by schistosomiasis * contraindications for propranolol use * do not accept to participate

Keywords: cirrhotic variceal bleeding primary prophylaxis
interventional radiology in bony lesions

Conditions: Bone Lesion

Summary: to explore the capability of the interventional radiology techniques in management of the painful bony lesions .

bone tumors may present as incidental findings, with pain or loss of function, or as fractures \[1\]. interventional radiology (ir) has experienced an exponential growth in recent years. technological advances of the last decades have made it possible to use new treatments on a larger scale, with good results in terms of safety and effectiveness\[2\] . today, ir represents a minimally invasive option of treatment for benign bony lesions (osteoid osteoma \[oo\], osteoblastoma, periosteal chondroma, etc.) and for palliation of metastases involving bone and soft-tissue sites beyond the liver and lung in an always-increasing number of cases \[3\]\[4\]. the aim of minimally-invasive ablation treatment is addressing the biological pain due to the stretching and irritation of the periosteum secondary to tumor growth and due to osteoclast-mediated bone resorption with the release of neurostimulating cytokines. the purpose of cementoplasty is to treat the mechanical pain for the instability from pathologic microfractures \[5\] radiofrequency ablation (rfa) and cementoplasty are safe, feasible, and promising clinical option for the management of painful bony tumors that are challenging for their morphology and location \[6\]. also , there is a broad range of indications for transarterial embolization (tae) in primary or metastatic bone tumors: to reduce operative haemorrhagic risks, to simplify or allow more definitive surgery, or in the context of pain palliation, fever, bleeding, or hypercalcemic and other rheological factors\[1\].

Eligibility criteria:
inclusion criteria: 1. painful primary bone tumors . 2. bone secondaries not amenable to radiation therapy . 3. histopathologically radioresistant bony tumors. 4. painful osteoporotic vertebral fractures. exclusion criteria: * 1- contraindications to contrast media 2- raised renal chemistry or chronic kidney disease . 3- pregnant patients . 4- abnormal coagulation profile . 5- contraindications to anesthesia .
biochemical effects of remote ischemic pre-conditioning on contrast-induced acute kidney injury

Conditions: Contrast-induced Acute Kidney Injury

Summary: this a prospective, double-blind, sham-controlled, randomized clinical trial to study the effects of remote ischemic preconditioning on acute kidney injury, vascular and renal biomarkers in patients with non-st elevation myocardial infarction and unstable angina undergoing coronary angiography and/or percutaneous coronary intervention.

the brick study is a prospective, double-blind, sham-controlled, randomized clinical trial in patients with non-st elevation myocardial infarction and unstable angina undergoing coronary angiography and/or percutaneous coronary intervention who are at high risk for acute kidney injury. the study will investigate the effects of remote ischemic preconditioning before cardiac catheterization on rate of acute kidney injury and novel biomarkers of renal injury/protection within 48hrs of coronary angiography and/or percutaneous coronary intervention.

Eligibility criteria:
inclusion criteria: * patient with non-st elevation myocardial infarction or unstable angina * referral for cardiac catheterization and percutaneous coronary intervention * contrast-induced acute kidney injury risk score of ≥11 exclusion criteria: * inability to give informed consent * unstable blood pressure (systolic blood pressure \> 200 or \<90 mmhg) * history of allergy to contrast media * peripheral vascular disease of upper limb * renal disease requiring dialysis * placement of arteriovenous fistula and arteriovenous graft

Keywords: remote ischemic conditioning contrast-induced nephropathy cardiac catheterization coronary artery disease
types of starch and their effect on blood glucose, appetite and food intake

Conditions: Obesity Prevention; Diabetes Prevention

Summary: the investigators hypothesize that different types of starch vary in their effects on appetite, blood sugar and food intake. in this study, subjects consumed five soups containing 50 g of whole grain, high amylose corn, regular corn or maltodextrin starches or no added starch at one week intervals. the investigators measured food intake at 30 minutes, appetite and blood sugar.


Eligibility criteria:
inclusion criteria: * healthy males with a bmi of 20-24.9 kg/m2 exclusion criteria: * females * smokers * breakfast skippers * individuals with diabetes or other metabolic diseases

Keywords: starch carbohydrates blood glucose food intake satiety appetite