Kornimate/medical-research-clean huggingface dataset:
correlation between clinical deterioration in schizophrenic patients and hair cortisol levels

Conditions: Schizophrenia; Schizo-Affective Disorder

Summary: the importance of stress as a possible deteriorating factor for schizophrenic patients is well documented. however, this notion is based on subjective experience and retrospective psychological analysis. a novel method of measuring cortisol using hair has a proven correlation to subjective stress in non-clinical as well as psychiatric clinical populations. this pilot study will attempt to assess the use of cortisol hair level, as a marker of stress, to predict clinical deterioration in schizophrenic patients.


Eligibility criteria:
inclusion criteria: * age 18-50 * diagnosis of schizophrenia or schizoaffective disorder, made by a senior psychiatrist. * signing an informed consent. exclusion criteria: * additional psychiatric diagnosis * boldness or hair shorter than 1cm * physiological disturbance in the hpa or the use of steroidal medication * neurological disease (past or present) or neurosurgery. * pregnancy * substantial chronic physical diseases/

Keywords: schizophrenia schizo-affective disorder stress cortisol panss
east-west hepatocellular carcinoma study group

Conditions: Carcinoma, Hepatocellular

Summary: the current treatment guidelines of hepatocellular carcinoma (hcc) of the american and european associations for the study of liver disease are based on the barcelona-clinic-liver-cancer classification (bclc), which does not recommend surgery in patients with large, multinodular and macrovascular invasive disease. the aim of this study was to investigate the role of hepatic resection in a large retrospective multicentric cohort of patients resected for hcc regardless of the bclc indications.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of hepatocellular carcinoma * candidate to liver resection as a curative treatment exclusion criteria: * uncertain diagnosis of hepatocellular carcinoma * uncertain follow-up data
study of safety, efficacy, and pharmacokinetics of topical acd440 in healthy volunteers

Conditions: Pain

Summary: phase 1 b placebo-controlled study in healthy volunteers to study safety, efficacy and pharmacokinetics of topical acd440 on normal skin, skin optimized for penetration and skin exposed to ultraviolet radiation

this is an exploratory study, no primary or secondary endpoints are being defined.

Eligibility criteria:
inclusion criteria: * healthy volunteer * fitzpatrick skin type ii or iii * women not childbearing potential or highly effective contraception exclusion criteria: * pregnancy, lactation * drug abuse * clinically significant illness * positive covid 19 test at screening or covid 19 infection in the past
community and physician perspectives regarding male youth human papillomavirus (hpv) disease and vaccination

Conditions: Papillomavirus Infections; Health Behavior; Attitude of Health Personnel; Human Papilloma Virus, Male

Summary: this is a minimal risk, anonymous, convenience sample, social behavioral study using qualitative descriptive survey methods. it is to ascertain community member, physician, resident and medical student perspectives regarding human papillomavirus (hpv) infection, associated diseases and to identify barriers which prevent these groups from ensuring that males 9-26 receive the three-shot vaccine series to prevent hpv infection. the research is focused on these questions: do community members understand the ease of transmission of the hpv virus in males 9-26? do community members, physicians, residents and medical students have knowledge of the associated diseases that may occur with the hpv virus infection in males age 9-26? do community members, physicians, residents and medical students know the ages in which males should receive the hpv vaccine three-shot series? what barriers prevent community members and physicians, residents and medical students from ensuring that males 9-26 receive the three-shot vaccine series to prevent hpv infection?

this is a minimal risk, anonymous, convenience sample, social behavioral study using qualitative descriptive survey methods. it is to ascertain community member, physician, resident and medical student perspectives regarding human papillomavirus (hpv) infection, associated diseases and to identify barriers which prevent these groups from ensuring that males 9-26 receive the three-shot vaccine series to prevent hpv infection. the research is focused on these questions: do community members understand the ease of transmission of the hpv virus in males 9-26? do community members, physicians, residents and medical students have knowledge of the associated diseases that may occur with the hpv virus infection in males age 9-26? do community members, physicians, residents and medical students know the ages in which males should receive the hpv vaccine three-shot series? what barriers prevent community members and physicians, residents and medical students from ensuring that males 9-26 receive the three-shot vaccine series to prevent hpv infection?

Eligibility criteria:
community participants inclusion all visitors to the pediatric or internal medicine university health shreveport clinics willing to complete a survey community study exclusion those do not wish to participate in the study those who english is not their first language clinical faculty, resident, and medical student study inclusion all louisiana state university shreveport health clinical faculty, resident, and medical student inclusion willing to to complete the online survey. clinical faculty, resident, and medical student study exclusion any lsu health shreveport clinical faculty, resident, and medical student which declines to take the survey or do not attempt to complete it.

Keywords: human papillomavirus vaccine hpv patient acceptance physician comfort male vaccination hpv associated cancers
long-term extension of recover- long-term effect of the 24h transdermal delivery of rotigotine in subjects with idiopathic parkinson's disease

Conditions: Parkinson's Disease

Summary: the objective of this open-label extension is to assess the long-term effect of the 24-hour transdermal delivery of rotigotine on motor function, sleep quality, and nocturnal and non-motor symptoms of parkinson's disease. the long-term safety and tolerability of the rotigotine transdermal patch will also be evaluated.


Eligibility criteria:
inclusion criteria: * completion of trial sp889 exclusion criteria: * ongoing serious adverse event assessed as related to trial medication

Keywords: neupro® rotigotine parkinson's disease
optimum length of catheter in the epidural space for labor analgesia in non-obese women: a randomised controlled trial of 4 cm versus 5 cm

Conditions: Labor Pain

Summary: epidural analgesia was introduced to the world of obstetrics in 1909 by walter stoeckel. over the following 100 years it has developed to become the gold-standard for delivery of intra-partum analgesia, with between 60 and 75% of north american parturients receiving an epidural during their labor. effective labor analgesia has been shown to improve maternal and fetal outcomes. one aspect of catheter insertion that has not been fully evaluated, and with very little recent work undertaken, is the optimal length of epidural catheter to be left in the epidural space. dislodgement or displacement of epidural catheter remains a significant cause for failure with analgesia. novel methods of fixation may further reduce the risk of catheter migration. another factor is the direction of travel within the epidural space, only 13% of lumbar catheters remain uncoiled after insertion of more than 4 cm into the epidural space. hypothesis: the investigators hypothesize that catheters inserted to 4 cm will have a lower rate of failure when compared to those inserted to 5 cm. objective: this study aims to evaluate the difference in quality of labor analgesia delivered by epidural catheters inserted to either 4 or 5 cm into the epidural space. this study will be conducted as an interventional double-blinded randomised control trial to establish best practice.

effective labor analgesia has been shown to improve maternal and fetal outcomes. it is of paramount importance to the obstetric anesthesiologist to optimize the quality of labor analgesia and identify any factors leading to ineffective epidural analgesia. one aspect of catheter insertion that has not been fully evaluated, and with very little recent work undertaken, is the optimal length of epidural catheter to be left in the epidural space. previous studies have advocated, for varying reasons, different lengths of catheter to be left in the space; these range from 2cm to 8cm. longer epidural lengths in the space can be associated with foraminal escape, leading to unilateral block, and intravascular insertion, prompting additional manipulation. shorter lengths have previously been associated with more frequent dislodgement. the directionality of the epidural catheter once in the space has been demonstrated to correlate with misdirection. the aim of the study would be to standardize practice in how much epidural catheter is threaded into the epidural space.

Eligibility criteria:
inclusion criteria: * all women aged 18 years and above. * in established second stage of labor. * 3-7 cm dilation at time of insertion. * women with bmi \< 40 kg/m2 exclusion criteria: * known contraindication to epidural insertion. * inability or unwillingness to provide written consent. * previous difficult epidural insertion. * previous failed epidural. * imminent instrumental or operative delivery. * dural puncture. * combined spinal epidural analgesia. * high bmi \> 40 kg/m2

Keywords: epidural catheter epidural analgesia labor epidural
influence of socio-economic factor on net survival in patients with multiple sclerosis in france ( ecovimus).

Conditions: C10.114.375.500

Summary: background: in comparison to general population, persons with multiple sclerosis have a higher risk to premature death with an estimate reduced life expectancy from 7 to 14 years. however, risk factors of mortality in ms are not well identified and well known. following the example of studies carry on cancers survival, socioeconomic status (ses) may have an influence on survival in ms. objective: the main objective of ecovimus is to estimate net survival according to ses using the european deprivation index as a proxy and other major covariates (gender, initial clinical phase and years of disease onset). methods: in order to answer to our main objective, we will use a retrospective cohort of ms patients with a medical follow-up in one of the 18 centers included in survimus ii, with a ms onset between 1960 and 2015 and with an informed vital at the date of december 31st, 2015. the ecological score of deprivation edi will be used as a proxy of the socioeconomic status and will be attributed from the geolocalisation to patient's residence address. net survival is directly associated to the notion of "mortality in excess". this mortality will be estimated comparing the observed mortality in ms patients to mortality in the general population. the advantage of this methodological approach is that cause of death is not needed. statistical analysis: the influence of socioeconomic status on the excess of mortality will be estimated thanks to a parametric multivariate model of excess rate mortality. this model will be adjusted on other major covariates (gender, age at disease onset, and initial clinical phase) and will include potential complex effects as non-linearity, non-proportionality and interactions. expected results: we expect to highlight some differences of net survival in ms patients according to socioeconomic group as it was already shown in cancers. this study will complete information on factors of mortality excess in ms and knowledge on socioeconomic inequalities encountered all along ms disease course.


Eligibility criteria:
inclusion criteria: * all patients registered in 17 selected french ofsep centres with core dataset with a sufficient level of data * diagnosis a of definite or probably ms according to poser or mcdonald criteria. with an ms onset date between january 1st, 1960 and december 31st, 2015. * with a postal residence address well informed in the ofsep database. exclusion criteria: * ms patients with less than one year's disease duration by the study end will be excluded.

Keywords: multiple sclerosis epidemiology socio-economic status net survival
traditional chinese medicine formula liu-wei-die-huang-wan in the treatment of osteoarthritis.

Conditions: Osteoarthritis

Summary: through an eight-week randomized, double-blind, placebo-controlled clinical trials formula to evaluate chinese herbal compound oa2 improve osteoarthritis of efficacy and safety.

this trial was a 8 weeks' randomized, double-blind, placebo-controlled study. the study was approved by the institutional review board of chung shan medical university hospital, and signed informed consent was obtained from each patient. eighty-one patients of osteoarthritis of knees or hips were enrolled in this study. inclusion criteria were: age 20 to 80 years; primary osteoarthritis in at least 1 knee, verified radiologically and scored (as normal, minimal, moderate or marked) for joint-space narrowing and marginal osteophytes in the medial, lateral and patellofemoral compartments; at least moderate pain during the 2 weeks before random assignment to treatment, as identified with the western ontario and mcmaster universities (womac) lk3.0 osteoarthritis index pain subscale. primary outcome measures: womac (western ontario and mcmaster universities) osteoarthritis index at week 4. secondary outcome measures: womac (western ontario and mcmaster universities) osteoarthritis index at week 2; visual analogue scale (vas), quality of life by sf-36, patient global assessment (pga), at week 2 and 4; the pga was scored from 0 to 4 (0 representing very good); biomarkers: hs-crp, esr.

Eligibility criteria:
inclusion criteria: * age ≥20 years old * written informed consent obtained * been diagnosed with knee or hip osteoarthritis * the physician interpretation of x-ray identification and joint space narrowing or bone spurs confirmed * in randomized trials before entering if used steroids or non-steroid medications osteoarthritis stable doses required at least one week * the womac osteoarthritis index of the degree of pain assessment in the past two weeks at least\> 4ppm pain exclusion criteria: * pregnant or breast-feeding women. * chemotherapy or radiation therapy in cancer patients

Keywords: traditional chinese medicine herbs liu-wei-die-huang-wan
the body constitution and quality of life of diabetic

Conditions: Diabetes Mellitus

Summary: diabetic mellitus is the fifth cause of death by the report of department of health in 2008, and it often cause the severity of other chronic diseases. neuropathy, retinopathy and renopathy are the most prevalent complications of dm, and they often influence the quality of life. 300 patients with diabetic neuropathy will be recruited in taichung veterans general hospital endocrine and metabolism clinics. body constitution questionnaire(bcq), diabetes impact measurement scales(dims), short form -36(sf-36) will be asked to filled up, neurological examination (ne), ac sugar, hba1c, lipid profiles, liver and kidney functions will be measured in order to evaluate the correlation between body constitution and quality of life on patients with diabetic complication.

diabetic mellitus is the fifth cause of death by the report of department of health in 2008, and it often cause the severity of other chronic diseases. neuropathy, retinopathy and renopathy are the most prevalent complications of dm, and they often influence the quality of life. traditional chinese medicine was often prescribed to treat diabetic complications and improve the quality of life .but the study of objective evaluation of diagnostics of traditional chinese medicine was few . it is important to analyze population of specific disease with well developed traditional chinese medicine diagnostic tool with good validation and consistency. 300 patients with diabetic neuropathy will be recruited in taichung veterans general hospital endocrine and metabolism clinics. body constitution questionnaire(bcq), diabetes impact measurement scales(dims), short form -36(sf-36) will be asked to filled up, neurological examination (ne), ac sugar, hba1c, lipid profiles, liver and kidney functions will be measured in order to evaluate the correlation between body constitution and quality of life on patients with diabetic complication.

Eligibility criteria:
inclusion criteria: * there is a history of diabetes and the injection or taking hypoglycemic agents. * aged 20 years of age, not limit to male or female . * consciousness clear, subjects are willing to sign consent after stating research purpose and process. exclusion criteria: * took the chinese medicine within the past month.
prp prevents recurrence of intrauterine adhesions

Conditions: Intrauterine Adhesion

Summary: effect of platelet-rich plasma (prp) on uterine scar fibrosis, endometrial receptivity and pregnancy outcome in patients with severe intrauterine adhesions

1. inclusion criteria: patients with intrauterine adhesions (afs score \>9 points); age 21 to 40 years old, with fertility requirements. 2. study design:prospective, randomized controlled cohort study, patients with intrauterine adhesions were randomized into two groups, the control group and the intervention group (intraoperative and postoperative 1 week postoperative prp). the surgical procedures and postoperative medication regimens were the same. 3. compare the biochemical pregnancy rate, clinical pregnancy rate, abortion rate and live birth rate after hysteroscopic resection in prp group and control group, and explore the effect of prp on pregnancy outcome after intrauterine adhesion.

Eligibility criteria:
inclusion criteria:patients with intrauterine adhesions (afs score \>9 points); age 21 to 40 years old, with fertility requirements - exclusion criteria:endometrial tuberculosis, endometrial polyps, uterine submucosal fibroids, endometrial hyperplasia, endometrial malignant lesions, premature ovarian failure, chromosomal abnormalities -
risk-adapted therapy for primary systemic (al) amyloidosis

Conditions: Amyloidosis

Summary: high-dose melphalan (mel) with autologous stem cell transplant (sct) is an effective therapy for systemic al amyloidosis (al), but treatment-related mortality (trm) has historically been high. the investigators performed a phase ii trial of risk-adapted sct followed by adjuvant dexamethasone (dex) and thalidomide (thal) in an attempt to reduce trm and improve response rates. patients with newly diagnosed al involving £2 organ systems were assigned to mel 100, 140, or 200 mg/m2 with sct, based on age, renal function and cardiac involvement. patients with persistent clonal plasma cell disease 3 months post-sct received 9 months of adjuvant thal/dex (or dex if there was a history of deep vein thrombosis or neuropathy). trm was 4.4%. thirty-one patients began adjuvant therapy, with 16 (52%) completing 9 months of treatment and 13 (42%) achieving an improvement in hematological response. by intention-to-treat, overall hematological response rate was 71% (36% complete response) with 44% having organ responses. with a median follow-up of 31 months, 2-year survival was 84% (95% confidence interval: 73%, 94%). risk-adapted sct with adjuvant thal/ dex is feasible and results in low trm and high hematological and organ response rates in al patients.

high-dose melphalan (mel) with autologous stem cell transplant (sct) is an effective therapy for systemic al amyloidosis (al), but treatment-related mortality (trm) has historically been high. the investigators performed a phase ii trial of risk-adapted sct followed by adjuvant dexamethasone (dex) and thalidomide (thal) in an attempt to reduce trm and improve response rates. patients (n=45) with newly diagnosed al involving £2 organ systems were assigned to mel 100, 140, or 200 mg/m2 with sct, based on age, renal function and cardiac involvement. patients with persistent clonal plasma cell disease 3 months post-sct received 9 months of adjuvant thal/dex (or dex if there was a history of deep vein thrombosis or neuropathy). organ involvement was kidney (67%), heart (24%), liver/gi (22%) and peripheral nervous system (18%), with 31% having two organs involved. trm was 4.4%. thirty-one patients began adjuvant therapy, with 16 (52%) completing 9 months of treatment and 13 (42%) achieving an improvement in hematological response. by intention-to-treat, overall hematological response rate was 71% (36% complete response) with 44% having organ responses. with a median follow-up of 31 months, 2-year survival was 84% (95% confidence interval: 73%, 94%). risk-adapted sct with adjuvant thal/ dex is feasible and results in low trm and high hematological and organ response rates in al patients.(british journal of haematology 2007;139:224-33)

Eligibility criteria:

Keywords: amyloidosis stem cell transplant
milk polar lipids consumption, lipid metabolism, and inflammation in menopausal women

Conditions: Cardiometabolic Risk

Summary: polar lipids have a specific chemical structure: they are an essential component of human cell membranes, play a major role in the nervous system and also influence the metabolic pathways including the cholesterol metabolism. polar lipids are used in food-processing industry for their emulsification properties. the most famous emulsifier is soya lecithin but milk also naturally contains natural emulsifiers such as polar lipids. the purpose of this research is to study plasma cholesterol variation after daily intake of milk polar lipids-fortified cheese products. the volunteers will have to consume 100 g of cheese product during four weeks instead of their usual cheese products. it is a bi-centric study with a centre in lyon (centre de recherche en nutrition humaine rhône-alpes) and clermont-ferrand (centre de recherche en nutrition humaine auvergne).


Eligibility criteria:
inclusion criteria: * menopausal women * of less than 75 years old- body mass index of 25 to 35 kg/m2 * waist circumference greater than 80 cm * normal (or not clinically significant) glycemic and lipid parameters exclusion criteria: * dairy products allergy or intolerance * smokers (more than five cigarettes/day) * hdl cholesterol greater than 1.5 mmol/l * medication that could interfere with lipid metabolism or intestinal microbiota (for example, no antibiotics within the 2 months before the study) * hormone replacement treatment for menopause

Keywords: nutrition milk polar lipids cardiometabolic risk