Kornimate/medical-research-clean huggingface dataset:
concomitant versus delayed cholecystectomy for management of obesity with gallstone

Conditions: Morbid Obesity; Gallstone

Summary: in this study we compare the results of concomitant cholecystectomy with bariatric surgery versus delayed cholecystectomy for management of gallstone in obese patients

in this study we compare the results of concomitant cholecystectomy with bariatric surgery versus delayed cholecystectomy for management of gallstone in obese patients. patients will be divided into 2 group: group1, will be operated by the bariatric surgery and cholecystectomy in the same session. group 2 will be operated by cholecystectomy at least 6 months after bariatric surgery or whenever develop complications

Eligibility criteria:
inclusion criteria: * bmi \> 35 * presence of gallstone * fit for laparoscopic surgery exclusion criteria: * bmi \< 35 * unfit for surgery * refuse to share in the study
basic mobility and physical activity during hospitalization for a hip fracture: functions needed and strategies used

Conditions: Hip Fractures

Summary: present study aim to gain an understanding of functions needed and strategies used for patients following hip fracture surgery to be independent in basic mobility activities during acute hospitalization, and establish knowledge of how much (or little) patients get out of bed. within the patients included in this cohort study (1), a subgroup will also be included in a satellite study (2), with a separate objective. definitions are presented in the detailed description below (objectives 1-2).

the objectives are; 1. to determine levels of physical activity among a broad representation of patients hospitalized following hip fracture surgery, and secondly to explore the association with 30-day readmission, and mortality. 2. to understand and define which functions and strategies are needed for patients hospitalized following hip fracture surgery to be independent in the basic mobility activities: getting in/out of bed, sit-to-stand from a chair and walking.

Eligibility criteria:
inclusion criteria: * patients who have undergone surgery for hip fracture at hvidovre hospital admitted to department 210/212 or at bispebjerg hospital department m1. * being able to participate in basic mobility activities with assistance pre-fracture (cumulated ambulation score (by recall) ≥ 3) * able to give written informed consent or having a relative/legal guardian to give written consent, not later than on 3rd postoperative day exclusion criteria: * postoperative weightbearing restrictions * multiple fractures * suspected pathological fracture due to cancer * terminal illness * post operative medical complications limiting the patient from getting out of bed * patients with permanent residence in a nursing home * patient unwilling to cooperate for testing
a study in patients with non-small cell lung cancer testing if erlotinib plus su011248 (sunitinib) is better than erlotinib alone

Conditions: Carcinoma, Non-Small-Cell Lung

Summary: this study will test whether treatment with erlotinib plus su011248 is better than erlotinib alone in patients with advanced/metastatic lung cancer who have received previous treatment with a platinum-based regimen


Eligibility criteria:
inclusion criteria: * patients with locally advanced/metastatic non-small cell lung cancer * prior treatment with no more than 2 chemotherapy regimens including a platinum-based regimen exclusion criteria: * prior treatment with any receptor tyrosine kinase inhibitors, vascular endothelial growth factor (vegf) inhibitors or other angiogenic inhibitors * history of or known brain metastases

Keywords: non-small cell lung cancer sunitinib erlotinib phase 2
a trial of ferumoxytol for the episodic treatment of iron deficiency anemia

Conditions: Iron Deficiency Anemia

Summary: to evaluate the safety and efficacy of ferumoxytol for the episodic treatment of iron deficiency anemia (ida).


Eligibility criteria:
key inclusion criteria include: 1. participants who completed participation in study amag-fer-ida-301 \[nct01114139\] 2. female participants of childbearing potential who are sexually active must be on an effective method of birth control and agree to remain on birth control until completion of participation in the study key exclusion criteria include: 1. experienced a serious adverse event (sae) related to ferumoxytol in study amag-fer-ida-301 2. female participants who are pregnant, intend to become pregnant, are breastfeeding, or have a positive serum/urine pregnancy test

Keywords: iron deficiency anemia feraheme ferumoxytol ida
correction of hallux valgus with the nexis® peca bunion implantable osteosynthesis medical device

Conditions: Hallux Valgus

Summary: the nexis® screw system is a range of osteosynthesis screws for the foot. nexis® bunion screws are class iib implantable medical devices. the primary objective of the study is to confirm the performance and effectiveness of the device under investigation for the correction of hallux valgus with the evaluation functional capacities of the patient's foot. it will be assessed with "general sub-score" of the efas questionnaire determined during the postoperative visit at 6 months. the evaluation of quality of life scores, angular correction, bone consolidation and occurrence of adverse events will also be carried out.


Eligibility criteria:
inclusion criteria: * patient with a hallux valgus foot pathology requiring correction * first line operation * use of the medical device concerned peca bunion * unilateral operation * patient aged 18 or over * isolated hallux valgus correction, without associated surgical procedures * patient able to respect the prescriptions and recommendations of his surgeon * patient able to read and understand the information note on the objectives of the study and the collection of their data * patient able to sign a consent form exclusion criteria: * patient with a contraindication to the device under investigation, * simultaneous participation in another clinical investigation protocol, * adults subject to legal protection (safeguard of justice, curatorship, guardianship), persons deprived of liberty, pregnant or breastfeeding women, minors.
"retrospective study to identify clinical factors related to a high benefit of axitinib in mrcc"

Conditions: Carcinoma, Renal Cell

Summary: retrospective study to collect data from patients with advanced/metastatic renal cell carcinoma previously treated with axitinib under standard clinical practice, to describe the clinical profile of the patients with a long response to axitinib and to try to identify clinical factors which could be related with the long response to axitinib, through the comparison between long responder patients and a group of refractory patients

to describe the clinical profile of patients with a long response to axitinib and to identify clinical factors which could be related with the long response to axitinib, through the comparison between long responder patients and a group of refractory patients. for this study are defined as "long responder", those patients who has a progression free survival (pfs) of at least 9 months since the initiation of axitinib treatment, and "refractory patients" those who have progression disease (pd) in the first response assessment since the initiation of axitinib treatment (estimated pfs ≤3 months\] secondary objectives * to describe the efficacy of axitinib treatment in the long responders group, and in relation with the treatment received before axitinib, in terms of pfs, orr, cb, os, ttp ... * to describe the tolerability and drug management of axitinib in this population. * to describe treatment received after axitinib in this population. study procedures: for the recruitment, the investigator should review the inclusion / exclusion criteria. in case of patients alive at the moment of the inclusion, the investigator will require them to sign the ic. with the data available in the medical records, the information requested will be recorded in the electronic data collection tool.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * patients with advanced or metastatic renal cell carcinoma, histologically confirmed, with at least one radiological response assessment * patients who had received axitinib treatment in second or further line with a pfs ≥9 months or dp (disease progression) at the first tumor assessment. * for the patients alive at the moment of the inclusion, patients must have a signed informed consent document exclusion criteria: * axitinib received out of the approved indication patients who do not meet any of the inclusion criteria

Keywords: axitinib, renal carcinoma, long responders
adapalene bpo gel pump, moisturizer spf 30 and foam wash in patients with mild to moderate acne vulgaris

Conditions: Acne

Summary: this is an open-label, multi-center study to be conducted in the united states. the study will examine the change in lesion count in subjects using epiduo® gel pump (once daily) in conjunction with cetaphil® dermacontrol™ foam wash (twice daily) and moisturizer spf 30 (once daily). subjects with a clinical diagnosis of mild or moderate acne who are eligible for treatment with epiduo® in accordance with the currently approved product labeling and who meet other inclusion/exclusion criteria are to be enrolled in the study and receive the study products for 8 weeks. efficacy and safety assessments include: complete lesion counts, cutaneous irritation assessment, end of study treatment questionnaire, photographic evaluation for oiliness, skin tone, and p acnes, hydration assessment, barrier function assessment, treatment compliance, and adverse event assessment.


Eligibility criteria:
inclusion criteria: - men and women of any race, 9 years or older, with a diagnosis of mild to moderate acne, who are eligible for treatment with adapalene bpo gel in accordance with the currently approved product labeling. exclusion criteria: - subjects with nodules and cysts, pregnant or breastfeeding, with any systemic or dermatological disorder, or topical condition or facial hair that could interfere with evaluations.
palladium-103 seed implant and single daily dosing of uroxatral vs. twice daily dosing of flomax- a 3 month retrospective efficacy analysis

Conditions: Prostate Cancer Patients Undergoing External Radiation and Seed Implantation

Summary: in the past ten years, newer drugs with more selective affinity for the alpha-receptor have been introduced. alfuzosin (uroxatral) and tamulosin(flomax are two second generation alpha-blockers. in the course of our clinical proctice, both drugs have been used routinely. this retrospective comparison is intended to be a priliminary comparison of their effectiveness and side effects.


Eligibility criteria:
inclusion criteria: * males age 45-80 years * diagnosis of prostate cancer * status post imrt and palladium-103 seed implantation and initiated alpha blocker therapy with alfuzosin10mg daily or tamulosin 0.4mg bid at time of seed implantation * baseline aua score\< or =12 * may be on antiandrogenand/or alpha reductase therapy * patients receiving imrt followed by palladium-103 brachytherapy implantation as the primary therapy for prostate cancer with curatives intent - exclusion criteria: * history of insulin-dependent diabetes * uncontrolled hypertention * history of symptomtic hypotension (including syncope and dizziness) * pre-existing obstructive uropathy based on history of bph and or acute urinary retention * pre-existing prostatitis either continuous or intermittent * concurrent use of any other anticholinergics * previous or concurrent usage of lhrh agonist
subsidence of cementless stem following arthroplasty for fracture neck of femur

Conditions: Hip Arthropathy

Summary: assessment of subsidence of cementless stem following arthroplasty for fracture neck of femur.

neck of femur fractures are occurring at an increased incidence, functionally independent patients without cognitive impairment can expect reasonable life expectancy, this indicates the need for a durable surgical option that optimises the chance to return to pre-injury functional status, with minimal risk of complications and reoperation. tha should be considered the gold standard producing better functional and quality of life outcomes lower reoperation rates and better cost effectiveness. tha is associated with better functional outcomes and a lower risk of revision surgery in self-sufficient, physically active patients , instability is the leading complication of conventional tha and occurs with a higher incidence ,tha remains the option of choice as it provides better functional outcomes. although the clinical outcomes of total hip arthroplasty (tha) in elderly patients with femoral neck fracture were reported to be better than hemiarthroplasty, hemiarthroplasty was frequently recommended in cases where the patient has a low functional level and/or osteoporosis and high rates of postoperative dislocation of total hip arthroplasty. hip joint replacement surgery is considered one of the most successful operations due to its high success and low complication rate , one possible risk factor for early failure of total hip arthroplasty (tha) is the subsidence of the femoral stem , cementless tha in particular could be susceptible to subsidence. cementless femoral stems ideally achieve direct integration between the stem surface and endosteal bone with the aim of decreasing the incidence of aseptic loosening. subsidence is defined as a distalization of the femoral stem in reference to the greater trochanter. measurement of subsidence of uncemented femoral stems can be used to evaluate the likelihood of long term stem component loosening and therefore clinical failure .

Eligibility criteria:
inclusion criteria: * cases that underwent cementless hip arthroplasty for fracture neck of femur exclusion criteria: - 1- malignancy. 2- previous plating. 3- revision for infection. 4- dysplasia. 5- sle and rheumatoid arthritis
brain imaging changes following proton therapy for pediatric primary central nervous system and base of skull tumors

Conditions: Malignant Central Nervous System Neoplasm; Malignant Skull Base Neoplasm

Summary: this trial gathers information from patients with primary central nervous system or base of skull tumors that receive proton beam therapy and see if certain imaging techniques can help detect radiation-related changes over time. this study may help providers learn more about proton beam radiotherapy and how to improve the way it is delivered.

primary objective: i. to establish linear energy transfer (let)-based models as early predictors for white matter changes on magnetic resonance imaging (mri) and diffusion tensor imaging (dti) sequences in pediatric patients following proton beam therapy for primary central nervous system (cns) and base of skull tumors. outline: patients' medical charts are reviewed.

Eligibility criteria:
inclusion criteria: * patients must have histologically confirmed central nervous system of skull base tumors * patient is going to undergo central nervous system (cns) or base of skull proton beam therapy exclusion criteria: * patients who have received prior therapeutic radiotherapy to the primary brain tumor site * patients who are unable to maintain follow-up through the phoenix children's hospital and mayo clinic arizona
costs and benefits of conformis itotal® knee replacement system versus standard total knee

Conditions: Osteoarthritis,Knee

Summary: the purpose of this study is to evaluate the costs and benefits of the conformis itotal® total knee replacement system versus standard total knee arthroplasty. this study is designed to illustrate the difference in cost between standard total knee replacements and the conformis itotal at a single institution.

study design the study is a two-arm single-center, consecutively enrolled retrospective study. patients enrolled will have previously received either an itotal cr knee replacement or a standard total knee replacement. the study site will be located in the united states. a minimum of 100 with a maximum of 120 patients will be enrolled in each study arm for a maximum of 200 - 240 patients. study duration this study involves retrospective data collection of operative and peri-operative information to determine the cost impact of several surgical variables. the study will be complete when the retrospective data has been collected on up to 120 patients per arm.

Eligibility criteria:
inclusion criteria: * patient has received an itotal or a standard total knee replacement * willingness to participate in the clinical study and to give informed consent, if necessary, as determined during irb review * \>18 years of age exclusion criteria: * participation in another clinical study that could confound results * patient is less than 3 months post-op

Keywords: osteoarthritis knee replacement patient-specific economics
a rollover study to provide chronic t-1249 to patients who completed study t1249-102

Conditions: HIV Infections

Summary: patients who complete study t1249-102 (must be currently failing a t-20 containing regimen to participate in this study) will receive t-1249 at a dose of 200mg daily in combination with a background antiretroviral regimen for 96 weeks. only patients that participated in study t1249-102 can participate in study t1249-105.


Eligibility criteria:
inclusion criteria: * completion t1249-102; * currently failing a t-20 containing regimen exclusion criteria: * non-completion of t1249-102.

Keywords: treatment experienced
autonomic modulation recovery after acute resistance exercise

Conditions: Resistance Training

Summary: to analyze the autonomic behavior in recovery post-acute resistance exercise performed in different intensities and body segments.

resistance training (rt) is recommended to people with different health condition. rt is recognized as safe and effective method of increasing muscle strength, physical fitness, muscle mass, and overall cardiovascular health. the magnitude of the rt effects is associated with the structure of the training program. understanding these aspects may provide guidance for the rt prescription while reducing potential risk of cardiovascular events associated with the recovery period after exercise. the objective of the study is to compare the acute responses of the autonomic nervous system post rt performed with different intensities (endurance and strength) in different body segments (ul and ll). our hypothesis is that different intensities and body segments influence the acute responses of the ans in the post rt recovery period.

Eligibility criteria:
inclusion criteria: * graduate students, * age between 18 to 30 years * healthy men, the physical activity readiness questionnaire (par-q) was used to determine safety and possible risk of exercising based on participants' health history, the according american college of sports medicine, 2010. * trained men, the international physical activity questionnaire (ipaq) was used to determine participants' physical activity level. exclusion criteria: participants who did not attend all the rt protocols and those with hr record with error higher than 5% (ectopic beats) will be excluded. -

Keywords: resistance training autonomic modulation heart rate exercise
reticular pseudodrusen progression study

Conditions: Age-related Macular Degeneration

Summary: age-related macular degeneration (amd) is the leading cause of irreversible blindness in industrial countries. reticular pseudodrusen (rpd) have been recognized as an additional phenotypic characteristic frequently observed in patients with amd. several studies have proven that the prevalence of rpd is associated with amd as well as a high risk of disease progression to geographic atrophy, the late form of dry amd. the pathogenesis of rpd is yet still incompletely understood. retrospective studies have demonstrated that the rpd affected retinal area increases over time. potential factors influencing progression of rpd have not been intensely studied and potentially predictive markers are yet unknown. the primary objective of this study is to characterize rpd progression in more detail and to identify predictive markers of rpd progression and development of amd late stages.


Eligibility criteria:
inclusion criteria: * informed consent * men and women, any race, aged 60 years or older at the baseline visit * presence of rpd without any other type of drusen, hypo/hyperpigmentation, geographic atrophy, choroidal neovascularization * patient is willing to undergo ocular examinations once every 12 for up to 24 months exclusion criteria: * presence or history of soft drusen, hypo-/hyperpigmentation, geographic atrophy or choroidal neovascularization in the study eye * ocular disease in the study eye that may confound assessment of the retina (e.g., diabetic retinopathy, uveitis) * any condition that would make adherence to the examination schedule of once every 12 months for up to 24 months difficult or unlikely, e.g., personality disorder, chronic alcoholism, alzheimer's disease or drug abuse
a 12 week study of mk0653a in patients who have been hospitalized for a possible heart problem (0653a-808)

Conditions: Hypercholesterolemia

Summary: the purpose of this study is to investigate the effect of an investigational cholesterol-lowering drug in patients who are currently taking an approved medication for hypercholesterolemia (high cholesterol levels) and have been hospitalized for a heart problem.


Eligibility criteria:
inclusion criteria: * patients greater than 18 years old, who were admitted to a hospital for an investigation of a heart problem and are currently receiving an approved medication to lower cholesterol exclusion criteria: * patients who have congestive heart failure (chf), uncontrolled high blood pressure, poorly controlled blood sugar, impaired kidney function, or hiv.
analysis of changes in blood glucose spinal epidural nerve block with steroids in patients with low back pain

Conditions: Glucose Level Change

Summary: this study aims to investigate the effect of different doses of dexamethasone used in epidural nerve block procedures on blood sugar levels. patients with spinal conditions such as stenosis or disc herniation will be enrolled. blood glucose and hba1c levels will be measured before the procedure, and participants will use continuous glucose monitoring devices for 2-3 days before the procedure. they will be randomly assigned to one of three groups: no dexamethasone, 5mg dexamethasone, or 7.5mg dexamethasone. blood glucose will be monitored for one week after the procedure, and follow-up will be done two weeks later to assess pain and blood sugar data. this study will help determine how steroid doses affect blood sugar, especially in elderly patients, and provide more accurate information than previous studies.


Eligibility criteria:
inclusion criteria: * patients need to epidural steroid injection for treating back pain * patients diagnosed with diabetes or prediabetes. exclusion criteria: * patients with poorly controlled blood sugar.(hba1c\>8.5)

Keywords: continous glucose monitering