Kornimate/medical-research-clean huggingface dataset:
exodx prostate evaluation in active surveillance patient population

Conditions: Prostate Cancer

Summary: the goal of this observational study is to test whether the exodx prostate test add value in biopsy decision making to patients with prostate cancer on an active surveillance regimen.

the current trial seeks to evaluate the role of the exodx prostate test in men with low and favorable intermediate prostate cancer undergoing an active surveillance regimen.

Eligibility criteria:
inclusion criteria: * male, 45+ years of age diagnosed with low-grade or favorable-intermediate prostate cancer and on an active surveillance regimen exclusion criteria: * clinical symptoms of urinary tract infection at time of enrollment. * history of invasive treatment for benign prostatic hypertrophy with in 6 months of enrollment. * known hepatitis or hiv * history of concurrent renal/bladder tumors
the mechanisms of manual therapy in the treatment of low back pain

Conditions: Low Back Pain

Summary: the purpose of this study is to determine whether a novel placebo for comparison to spinal manipulation is believable and creates similar expectation for treatment effectiveness as the studied spinal manipulation technique. additionally, we wish to compare outcomes related to low back pain, function, and pain sensitivity between people receiving the placebo, spinal manipulation, and no therapy.


Eligibility criteria:
inclusion criteria: * currently experiencing low back pain which does not extend below the knees * rate the low back pain as a minimum of 4/10 at worst over the past 24 hours * appropriate for conservative management of low back pain * english speaking exclusion criteria: * surgery to the low back over the past 6 months * systemic disease known to effect sensation * other chronic pain condition unrelated to low back pain * fracture as a cause of low back pain

Keywords: low back pain spinal manipulation manual therapy placebo
a pilot study using weightloss and exercise to prevent recurring gestational diabetes in obese women

Conditions: Gestational Diabetes

Summary: the purpose of this study is to examine the feasibility of recruiting and providing a behavioral weight loss program prior to pregnancy to reduce gestational diabetes recurrence.


Eligibility criteria:
inclusion criteria: * gdm in last pregnancy * bmi 30-40 * age 18-40 * 1-5 years since last pregnancy * non-smoking * english or spanish speaking * planning to have a baby but willing to use birth control during the 3 month weight loss program exclusion criteria: * 3 or more miscarriages * history of infertility * type 1 or type 2 diabetes * any weight loss since last pregnancy (based on last pre-pregnancy weight) * history of major psychiatric illness, drug abuse, or unsafe dieting practices * history of bariatric surgery, major medical conditions that prohibit physical activity or dietary intervention (md consent may be required)

Keywords: recurring gestational diabetes prevention
liver injury by statins in patients with history of hepatitis b virus infection

Conditions: Liver Injury; Hepatitis B Virus Infection History

Summary: the purpose of this study is to investigate the incidence of liver injury by statins in coronary heart disease (chd) patients with history of hepatitis b virus (hbv) infection.


Eligibility criteria:
inclusion criteria: * patients with chd receive long-term statin treatment exclusion criteria: * alt is over uln at baseline * infection of hepatitis a virus, hepatitis c virus or hepatitis e virus * triglyceride is over 4.5 mmol/l * decompensated liver cirrhosis (child b or c) * active stage of hbv * infection of burkitt's lymphoma virus or cytomegalovirus, or other acute infectious disease * congestive heart failure * malignant tumor * autoimmune disease * receive other potential hepatotoxicity drugs such as immunosuppressant, antituberculotic and non-steroid anti-inflammatory drug.

Keywords: statin hepatitis b virus
protracted mixture of local anesthetics for major foot and ankle surgery

Conditions: Postoperative Pain

Summary: to extend the duration of peripheral nerve blockade after major foot and ankle surgery the investigators randomize the postoperative treatment with either perineurial sciatic nerve blocks with 0.5% bupivacaine-epinephrine with or without dexamethasone.


Eligibility criteria:
inclusion criteria: * age \> 17 * scheduled major foot and ankle surgery * written informed consent * fertile women in anti conceptive treatment * fertile women not in anti conceptive treatment, but with negative urin-hcg on day of surgery exclusion criteria: * patients not able to understand or cooperate * allergies to medicines involved * daily buse of steroids * daily use of opioids

Keywords: local anesthetics perineural nerve blocks perineurial dexamethasone
intervention based on implicit theories of personality: effects on depression and bullying

Conditions: Depression; Bullying

Summary: this study evaluates the efficacy of an intervention based on the implicit theories of personality (itp) in spanish adolescents. half of participants received the itp intervention, while the other half received an educational intervention.

depression and bullying are two problems arising in childhood and adolescence, which cause severe suffering. although there are good intervention programs for children and adolescents at risk, the results for universal interventions have generally been poor. the current project will test the efficacy of an intervention based on the implicit theories of personality (itp). this procedure has recently been developed at us by david s. yeager and colleagues, with extraordinary results in the reduction of depression, stress, and aggression. the project includes the following aims: (1) the evaluation of the efficacy of the itp on depressive symptoms (study 1) and aggressive behavior (study 2) in spanish adolescents; (2) to test whether the intervention changes biological and cognitive variables; (3) to identify whether development and sex moderates the effects of the intervention; and (4) to test whether temperament moderates the effect of the intervention. the study involves the evaluation of the intervention in a sample of around 900 adolescents (12-18 years), randomly allocated to experimental and control condition. it is a field experiment conducted in high schools and involves multiple measures over time (self-reports and parent reports; as well as levels of cortisol, testosterone and dhea in saliva in a subset -50%- of the participants). in summary, the project aims to respond to the challenge of health and wellness in the population through a randomized controlled trial with multiple sources of measure and from a biopsychosocial perspective. the itp intervention has the potential to become a universal intervention to help reduce the rates of depression and bullying.

Eligibility criteria:
inclusion criteria: * informed consent by the adolescents and their parents. * to be fluent in spanish.

Keywords: adolescence prevention emotional disorders aggressive behavior
the efficacy of everolimus in reducing total native kidney volume in polycystic kidney disease transplanted recipients

Conditions: Autosomal Dominant Polycystic Kidney Disease

Summary: the investigators multicenter randomized open-labelled study will investigate the efficacy of an everolimus based immunosuppression in reducing total native kidney volume in kidney recipients with autosomal dominant polycystic kidney disease compared to a calcineurin inhibitor-based immunosuppression.

kidney graft recipients receiving a firs kidney graft (between 6 months and 5 years post-transplantation) will be randomized 1:1 to receive an everolimus based immunosuppression (in association with steroids and mycophenolate mofetil) or to continue their calcineurin inhibitor-based immunosuppression regimen. the primary objective will be the reduction of total native kidney volume after a 2-years treatment period.

Eligibility criteria:
inclusion criteria: * age between 18 and 75 years-old * recipients of a first kidney graft between 6 month and 5 years ago with a stable egfr above 30 ml/min/1,73m2 * contraception for female recipients to avoid pregnancy * valid health insurance during the study period exclusion criteria: * signed informed consent not obtained

Keywords: autosomal dominant polycystic kidney disease cyst kidney liver kidney transplantation if/ta fibrosis dsa mtor inhibitors calcineurin inhibitors
examination of the impact of calmigo's stress management device on vascular heath and cardiovascular disease risk.

Conditions: Myocardial Infarction

Summary: the primary purpose of this study is to determine if there are significant differences with respect to baseline between those randomized to cgo and standard-of-care versus standard-of-care alone after completing 12-weeks of therapy in terms of peripheral endothelial function measured by endopat.

100 patients who have recently had an acute myocardial infarction ( heart attack) and are under going clinically indicated cardiac rehabilitation will undergo baseline testing including endopat testing, mental stress testing, blood tests for cardiovascular disease biomarkers , physical assessments \& survey questionnaires. patients then will be randomized to either calmiogo stress management device + standard of care treatment or just standard of care treatment. those randomized to calmigo stress management device treatment will be instructed to use the hand device much like an inhaler once a day for 12 weeks. after 12 weeks of rehabilitation both groups will return for reassessment of baseline tests.

Eligibility criteria:
inclusion criteria: * 18 years of age or older * ability to use the camligo device for 12-weeks * willingness to complete study questionnaires, blood tests,\& endopat testing at the beginning and end of study * patients who have had a recent mi who will be undergoing clinically indicated cardiac rehabilitation * patients who have had a coronary or structural intervention performed in the cardiac catheterization laboratory within the last month, including: coronary stenting; coronary balloon angioplasty; transcatheter aortic valve replacement; mitral valve interventions; patent foramen ovale closures; alcohol septal ablation; paravalvular leak closure. * patients being seen in the chest pain clinic for atypical chest pain exclusion criteria: * cognitively impaired patients * patient with bipolar disorder, psychosis or delusional disorder * history of substance abuse or dependence * history of suicidality * unstable cardiovascular or pulmonary disease * history of seizures * latex allergy
computer-based training in cognitive behavior therapy (cbt4cbt)

Conditions: Substance-Related Disorders

Summary: in this behavioral trial 80 substance abusing individuals will be randomly assigned to either treatment as usual in the substance abuse clinic of the newington, ct va hospital or treatment as usual plus 8 hours of access to the 'cbt for cbt' computer program over a period of 8 weeks. primary outcomes will be retention in treatment and reduction in substance use (percent days abstinent, confirmed by urine toxicology screens). the patients' ability to demonstrate coping skills through a computerized role-play evaluation will be a secondary outcome. a six-month follow-up will assess durability and/or delayed emergence of effects.

this pilot study aims to evaluate the feasibility and effectiveness of adding a computer based training program in cognitive behavior therapy ("cbt4cbt") for the treatment of addictions in a va substance abuse outpatient clinic. key secondary aims are to assess the impact of adding cbt4cbt to standard care on treatment attendance, engagement, retention, and to investigate if certain process measures are associated with substance use outcomes. approximately 80 patients enrolled in the newington outpatient substance abuse treatment program (satp) will be randomly assigned to either (a) treatment as usual, or (b) treatment as usual plus exposure to the cbt4cbt program.

Eligibility criteria:
inclusion criteria: * 18 years and older * recent (within 3 months) substance use * meet current dsm-iv (diagnostic and statistical manual-iv) criteria for substance use disorder * fluent in english or at least a 6th grade reading level * can commit to at least 8 weeks of treatment and willing to be randomized to treatment exclusion criteria: * unstable housing situation * likelihood of going to prison during the intervention portion of study * recent opiate or benzodiazepine prescription
latinos understanding the need for adherence in diabetes

Conditions: Type 2 Diabetes; Glycemic Control; Cardiovascular Risk Factors; Psychological Distress

Summary: the latinos understanding the need for adherence in diabetes (luna-d) study, is a randomized controlled trial testing the effectiveness of an integrated behavioral health and primary care chronic care disease management intervention for low income latino patients with type-2 diabetes mellitus (t2dm) that have 2 or more chronic health conditions. luna-d focuses on diabetes management and behavioral health care integration.

luna-d proposes to test the ability of a fully integrated behavioral health and primary care diabetes management intervention in a federally-qualified community health care setting to improve multiple clinical and behavioral outcomes. luna-d will recruit non-insulin using adult type two diabetes mellitus (t2dm) patients with two or more chronic diseases. half will be randomized to the special intervention (si) arm and half to the usual care (uc) arm. the si is an intensive intervention including fully integrated clinical visits with a medical provider (mp) co-located with a behavioral health counselor (bhc) and peer-led evidence-based group health education sessions and proactive care coordination. usual care is represented by passive appointments with the primary care physician and passive referrals to behavioral health and traditional health education. biological measurements will be taken at baseline, 3-, 6-, 9- and 12-months to detect changes in glycemic control. clinical lab measures, medication adherence, weight, health behaviors and psychosocial measures will also be obtained across the study.

Eligibility criteria:
inclusion criteria: this study targets non-insulin using t2dm patients with 2 or more chronic conditions. the primary eligibility criteria are as follows: * self-identify as hispanic/latino * be a registered \& established patient of syh * 18 years of age or older * have an established diagnosis of t2dm (but not currently using insulin) * not currently participating in any other diabetes or cvd intervention program * have 2 or more cvd risk factors (e.g., depression, anxiety, hypertension, dyslipidemia, obesity, or smoking) exclusion criteria: individuals will be excluded if they: * are pregnant or planning to get pregnant (temporary exclusion, may qualify 6-months postpartum) * have plans to move out of the area in the next 12 months * have pre-existing health problems so severe as to prohibit informed consent and study attendance * have severe diabetes, including renal disease and/or on dialysis * have severe psychosocial conditions under the care of a psychiatrist (e.g., severe depression, bipolar disorder, or schizophrenia)
a clinical trial to evaluate the sensitivity of a number of clinical and psychological outcome measures for cancer patients being treated at the hospital day care unit or (partially) at home

Conditions: Cancer

Summary: this pilot study aims to evaluate the sensitivity, variability and responsiveness of a number of predefined clinical and psychological outcome measuring tools in an ambulant cancer treatment setting (home vs. hospital). the measuring tools will be evaluated in two patient cohorts. one cohort is treated as per standard of care at the outpatient hospital, the other cohort is receiving (partial) cancer treatment at home. a second objective is to create a costs inventory representing total costs for an ambulant treated cancer patient.


Eligibility criteria:
inclusion criteria: * starting new oncological treatment at the outpatient hospital. * ecog ≤ 2 * living within 30 minutes of drive from the hospital exclusion criteria: * important comorbidity (ecog \> 2) * simultaneous radiotherapy treatment * language barriers or communication difficulties * problematic venous access * known problems with administration of the therapy
pharmacokinetic/pharmacodynamic drug-drug interaction of da-1229 and metformin after oral administration in healthy male subjects

Conditions: Type 2 Diabetes Mellitus

Summary: this is a randomized, open-label, multiple dosing, three-way crossover clinical trial to investigate the pharmacokinetic/pharmacodynamic drug-drug interaction of da-1229 5 mg and metformin ir 1000 mg after oral administration in healthy male volunteers.


Eligibility criteria:
inclusion criteria: * age between 20 to 45, healthy male subjects(at screening) * body weight between 55kg - 90kg, bmi between 18.0 - 27.0 * fpg 70-125mg/dl glucose level(at screening) * subject who totally understand the progress of this clinical trials, make decision by his free will, and signed a consent form to follow the progress. exclusion criteria: * subject who has past or present history of any diseases following below.(liver including hepatitis virus carrier, kidney, neurology, immunology, pulmonary, endocrine, hematooncology, cardiology, mental disorder) * subject who had gi tract disease(crohn's disease, ulcer, acute or chronic pancreatitis) or surgery(appendectomy, hernioplasty are excluded) * subject who had drug(aspirin, antibiotics) hypersensitivity reaction * subject who already participated in other trials in 2 months * subject who had whole blood donation in 2 months, or component blood donation in 1 months or transfusion in 1 months currently.
effect of mindfulness-based relapse prevention program on readiness for change and self-efficacy among clients with substance use disorders

Conditions: Substance Use Disorders

Summary: the treatment process of substance addiction is applied principally by psychiatrists, psychologists, and psychiatric mental health nurses. in this respect, psychiatric mental health nurses have a crucial role to play. as they are the one who is in touch with the patients for 24 hours, psychiatric nurses can enhance the treatment process a lot through the application of a mindfulness-based relapse prevention program. as drug abuse is such a devastating affliction, further knowledge about specific traits that may increase the chances of a successful recovery would be greatly beneficial to enhance treatment and decrease relapse rate. accordingly, this study will be conducted to determine the effect of mindfulness-based relapse prevention program on readiness for change, and efficacy among clients with substance use disorder. aims of the study the aim of this study is to: examine the effect of the mindfulness-based relapse prevention program on readiness for change and self-efficacy among clients with substance use disorder during the rehabilitation phase. research hypothesis clients with substance use disorder who attend mindfulness-based relapse prevention program sessions exhibit higher levels of readiness for change and self-efficacy compared to those who receive conventional hospital treatment.


Eligibility criteria:
inclusion criteria: * able to read and write. * able to communicate and willing to participate in the study. * male patients only exclusion criteria * patients who are only alcoholics will be excluded. * diagnosed with suds with mental illness comorbidity.

Keywords: mindfulness relapse prevention readiness for change self-efficacy substance use
the diagnostic value of aptt/fibrinogen ratio in pulmonary embolism

Conditions: Acute Pulmonary Embolism

Summary: from january 1, 2023 to december 30, 2023, patients who were suspected of pulmonary embolism and underwent ctpa examination at nanyang hospital of southern medical university were divided into pulmonary embolism group and non pulmonary embolism group. 1. collect relevant data, including gender, age, primary disease, ctpa imaging and reports, bnp, troponin, electrocardiogram, cardiac ultrasound, pt, aptt, tt, fibrinogen, d-dimer, etc., and analyze demographic data, pulmonary embolism risk grading, aptt/fibrinogen ratio, and determine their cut-off values through statistical analysis of the two groups. 2. follow up on the aptt/fibrinogen ratio after anticoagulation treatment and bleeding in the pulmonary embolism group.


Eligibility criteria:
inclusion criteria: 1. voluntary signing of informed consent form; 2. when signing the informed consent form, the age is equal to or greater than 18 years old, regardless of gender; 3. from january 1, 2023 to december 30, 2023, the patient was diagnosed with suspected pulmonary embolism at the southern hospital of southern medical university and underwent enhanced pulmonary artery scanning examination. exclusion criteria: 1. patients with gastrointestinal bleeding, severe trauma, acute coronary syndrome, severe liver disease (childc grade), and coagulation dysfunction; 2. patients with pulmonary embolism diagnosed outside the hospital and regular anticoagulation; 3. patients undergoing regular anticoagulant therapy such as atrial fibrillation and valve replacement; 4. patients deemed unsuitable for participation in this study by the researchers.
effects of physical activity with online support for individuals with chronic widespread pain (cwp)

Conditions: Chronic Widespread Pain

Summary: the aim is to evaluate a novel treatment routine where contact through a smart phone/computer is used for online support for patients suffering from chronic widespread pain (cwp). the outline is that patients are encouraged to perform physical activity during a period of 12 months with online support from a physical therapist.

the intervention follows principles from the theories of person-centered care and self-efficacy. the examinations performed at baseline and after six months were conducted by blinded examiners at a visit at the primary health care centers. all participants developed a person-centered health plan for physical activity together with a physiotherapist. the intervention group was supported with a digital platform for six months.

Eligibility criteria:
inclusion criteria: * fulfilling the american colleague of rheumatology (acr) 1990 criteria for chronic widespread pain (cwp) * access to a smart phone or computer exclusion criteria: * other serious diseases that cause pain or hinder exercise, such as heart disease, neurological disease or severe osteoarthritis * unable to speak or read swedish