development of methods for effective treatment and improvement of common somatic diseases in children

Conditions: Respiratory Diseases; Congenital Heart Defects

Summary: the goal of the clinical study is to clarify the course of common congenital, infectious, and non-infectious diseases in children living in uzbekistan, and to develop methods for their treatment and rehabilitation. the main questions it aims to answer: * analysis of common congenital diseases among children; * analysis of commonly diagnosed bronchopulmonary and cardiovascular diseases among children; * based on the results of the primary research, common diseases among children will be identified; * analysis of existing treatment methods and their effectiveness; * development of modern methods of treatment and rehabilitation of children.

children's health is a priority in modern medicine. some childhood diseases are most often encountered in the practice of pediatricians and family doctors. children with these diseases need early diagnosis, treatment, and rehabilitation. patient selection criteria are: * children from birth to 15 years; * children permanently residing in the territory where the clinical examination is carried out; * children included in the group of "frequently ill children"; * patients without severe chronic diseases. exclusion criteria: * teenagers over 15 years old; * patients with severe neurological and mental diseases; * patients with endocrinological diseases; * patients with long-term chronic somatic diseases; * children without genetic pathologies. clinical research methods: * collection of anamnestic data; * general examination of patients (auscultation, palpation, percussion); * if necessary: consultation with a geneticist and pediatric doctors of various specialties (cardiologist, surgeon, urologist, nephrologist, otolaryngologist, pulmonologist, immunologist, allergist) * standard laboratory tests (general analysis of blood, urine, feces); * standard biochemical studies (microelements of blood and enzymes in venous blood); * instrumental studies: chest x-ray, ultrasound examination of internal organs (chest and abdominal organs), computed tomography (chest and abdominal organs); * study of immunological status (cellular immunity, according to standard methods); immunological research methods - flow cytometry, miu/ml: immunogram - cd3, cd3/4, cd3/8, cd19, cd16/56, cd3/16/56, cd3/hla-; and others; * study of antioxidant status (tas, using the psr method, mmol/l); * assessing the quality of life of patients (methods: pedsqltm 4.0; hbsc, indicator: total score on the screening survey).

Eligibility criteria:
inclusion criteria: * children from birth to 15 years; * children permanently residing in the territory where the clinical examination is carried out; * children included in the group of "frequently ill children"; * patients without severe chronic diseases. exclusion criteria: * teenagers over 15 years old; * patients with severe neurological and mental diseases; * patients with endocrinological diseases; * patients with long-term chronic somatic diseases; * children without genetic pathologies.

Keywords: children adolescents heart diseases lung diseases congenital malformations