cross-control study on the effect of peritoneal rest on peritoneal transport function in peritoneal dialysis patients

Conditions: Chronic Kidney Disease 5D

Summary: the investigators will carry out a prospective cross-over, pre-and post-controlled clinical study : 36 patients with continuous ambulatory peritoneal dialysis with high/high average transport will be recruited and treated with continuous ambulatory peritoneal dialysis and intermittent peritoneal dialysis at night (using automatic peritoneal dialysis machine) for 1 month respectively. the changes of peritoneal transport function and ultrafiltration volume before and after the two dialysis methods will be compared.

1. inclusion criteria * continuous ambulatory peritoneal dialysis for more than 3 months; * the peritoneal transport function is high/high average transport (d/pcr\>0.65 at 4 hours in the peritoneal balance test); * sign the informed consent form voluntarily. 2. exclusion criteria * patients with peritonitis in the past 3 months; * patients with acute complications such as cardiovascular events, pulmonary infection and gastrointestinal bleeding in the past 3 months; * the doctor judged that it was not suitable for the patients in this study for other reasons. 3. treatment plan the patients will be divided into two groups randomly: group a carry on continuous ambulatory peritoneal dialysis (the original dialysis plan) for 1 month, and then changed to intermittent peritoneal dialysis at night (using automatic peritoneal dialysis machine，the concentration and dosage of dialysate are consistent with the original plan) for 1 month; group b carry on intermittent peritoneal dialysis at night (using automatic peritoneal dialysis machine，the concentration and dosage of dialysate are consistent with the original plan) for 1 month, and then change to continuous ambulatory peritoneal dialysis (original dialysis plan) for 1 month. 4. observation indicators main observation indicators: changes in peritoneal transport rate (represented by 4-hour d/pcr in the standard peritoneal balance test) and ultrafiltration volume (represented by 4-hour ultrafiltration volume in the standard peritoneal balance test) before and after daytime dry abdomen (intermittent peritoneal rest) and continuous peritoneal dialysis. secondary outcome measures: changes in il-1, il-6 and tnf- α， vegf and ctgf of the exudate in the standard peritoneal balance test before and after daytime dry abdomen (intermittent peritoneal rest) and continuous peritoneal dialysis . changes of body weight, blood pressure, hemoglobin, albumin, calcium, phosphorus, electrolyte, urea clearance index, etc. before and after daytime dry abdomen (intermittent peritoneal rest) and continuous peritoneal dialysis.

Eligibility criteria:
inclusion criteria： * continuous ambulatory peritoneal dialysis for more than 3 months; * the peritoneal transport function is high/high average transport (d/pcr\>0.65 at 4 hours in the peritoneal balance test); * sign the informed consent form voluntarily. exclusion criteria： * patients with peritonitis in the past 3 months; * patients with acute complications such as cardiovascular events, pulmonary infection and gastrointestinal bleeding in the past 3 months; * the doctor judged that it was not suitable for the patients in this study for other reasons.