Kornimate/medical-research-clean huggingface dataset:
study of combined intercostal and diaphragm pacing for artificial respiration in quadriplegic patients

Conditions: Quadriplegia

Summary: objectives: i. determine whether combined intercostal muscle and diaphragm pacing can maintain full-time ventilatory support in patients with ventilatory dependent quadriplegia who are not candidates for phrenic nerve pacing alone. ii. evaluate the efficacy of the medlink device to produce synchronous intercostal and diagram activation in these patients.

protocol outline: patients have a medlink spinal cord electrode surgically implanted and attached to a radiofrequency receiver implanted subcutaneously over the anterior chest wall. if substantial inspired volumes can be generated by intercostal pacing, a phrenic nerve cuff electrode and radiofrequency receiver are implanted, and patients undergo combined intercostal muscle and diaphragm pacing. completion date provided represents the completion date of the grant per oopd records

Eligibility criteria:
protocol entry criteria: --disease characteristics-- ventilator dependent quadriplegics who are not candidates for phrenic nerve pacing alone must have bilateral partial or unilateral phrenic nerve function must have been on ventilator support for at least 6 months and unweanable --patient characteristics-- cardiovascular: no active cardiovascular disease pulmonary: no active lung disease other: no active brain disease stable condition

Keywords: environmental/toxic disorders neurologic and psychiatric disorders rare disease spinal cord injury
core exercises effects on muscle imbalances

Conditions: Muscle Atrophy or Weakness; Muscle Contraction; Core Stability

Summary: this study aims in investigating the effects of a core muscles' strengthening program on core muscles' atrophy and contraction ability. twenty healthy adults recruited and randomly assigned to either a 5-week training group developed to activate and strengthen local trunk muscles or a control group. the training program includes isometric bridging exercises from various positions and dynamic exercises for lumbopelvic stability. core muscles' thickness will be assessed at rest and contracting conditions, prior and after the intervention, using ultrasonography.

a total of 136 male and female adults, members of local gyms, were initially invited for participation in the study after giving their written consent. after a second contact with the participants, forms regarding the inclusion and exclusion criteria were sent for completion. of the 136 that initially answered positively for participation, 62 did not meet the inclusion criteria, based on their reports and the clinical examination by a health professional. of the remaining 74 participants, 32 were excluded because of previous low back pain incidents and other recent musculoskeletal injuries that led to rehabilitation, while 22 decided to not participate for personal reasons. the remaining 20 participants were randomly allocated to either training group or intervention group, by a neutral, blinded investigator who had no involvement and was unaware of the study purposes. the intervention group will be trained and supervised by a certified fitness instructor in a gym class, who will be responsible for the correct execution of the exercises. the duration of the intervention will be 5 weeks, 3 times a week.

Eligibility criteria:
inclusion criteria: * 18 to 45 years old * trained recreationally at least 2 times a week, for the past 3 years * healthy * no musculoskeletal injuries in the 6 months prior to the study exclusion criteria: * history of chronic low back pain * history of hip, pelvic or low back surgery * history of acute low back pain with duration at least 1 week, the preceding 6 months * involvement in similar core stability training programs the last 12 moths prior to this study
time-effect of montelukast protection

Conditions: Exercise-Induced Asthma; Asthma

Summary: the aim of this study is to verify mnt time of onset of protection against eib in asthmatic children by evaluating different time intervals between dosing and challenge, after a single-dose and after three days of once a day mnt administration.

within few days after a baseline exercise challenge, children was randomized to a double blind, placebo-controlled, three day doses, crossover study design. in practice each eligible patient was randomized by a computer-generated schedule to receive in sequence double-blind treatments with placebo or mnt (5 mg). patients in sequence 1 received mnt, then crossed over to matching placebo; vice versa the case was for patients in sequence 2. placebo and active treatments were separated by a 7-10 day wash-out period. each child was assigned to one out of seven groups in order to perform the exercise challenge at different time intervals from drug administration which occurred always at 8.00 a.m. on day one the challenge was performed in the different groups 1, 2, 3, 4, 5, 6, and 8 hours after drug administration, respectively. then treatment was continued as a single day dose for three consecutive days and a third challenge was then performed at the same time of the day.

Eligibility criteria:
inclusion criteria: * children with exercise-induced asthma exclusion criteria: * viral infections * montelukast treatment

Keywords: asthma exercise-induced bronchoconstriction montelukast clinical protection children time effect
comparative study of intravenous labetalol versus intravenous nitroglycerin versus sublingual nifedipine

Conditions: Severe Preeclampsia

Summary: pre-eclampsia (pe) is one of the most frequent pregnancy complications and is one of the main causes of maternal and fetal morbidity and mortality in its severe form.control of blood pressure is of crucial importance to avoid maternal and fetal complications.therapeutic modalities that can target the underlying pathophysiological changes and reverse the endothelial dysfunction could help to ameliorate the systemic manifestations in patients with severe pe. either intravenous labetalol and nitroglycerine as well as sublingual nifedipine have been frequantly used for the management of acute severe hypertension in pe

pre-eclampsia (pe) is one of the most frequent pregnancy complications and is one of the main causes of maternal and fetal morbidity and mortality in its severe form. pre-eclampsia characterized by * rising blood pressure (bp ≥ 140/90 that occurs after 20 weeks of gestation in a woman with previously normal bp. * . proteinuria (≥300mg/24hr . this correlates with 30mg/dl or ≥1+ on urine dipstick) * edema control of blood pressure is of crucial importance to avoid maternal and fetal complications. the pathophysiology of pre-eclampsia is most likely inadequate placentation, leading to endothelial dysfunction and reduced nitric oxide bioavailability. therapeutic modalities that can target the underlying pathophysiological changes and reverse the endothelial dysfunction could help to ameliorate the systemic manifestations in patients with severe pe. either intravenous labetalol and nitroglycerine as well as sublingual nifedipine have been frequantly used for the management of acute severe hypertension in pe . nitroglycerine, a nitric oxide donor with low oral bioavailability and a very short half-life, has a potent venodilator effect in low doses and affects arterial tone at high doses labetalol is useful as it contains both selective, competitive, alpha1-adrenergic antagonism and non-selective, competitive, beta-adrenergic (b1 and b2) blocking activity in a single agent nifedipine is a dihydropyridine calcium channel blocker. its main uses are as an antianginal and antihypertensive

Eligibility criteria:
inclusion criteria: * the study will include 60 adult female patients ( 18 to 40 years old) with sever pre-eclampsia, who were being managed with mgso4 loading and maintenance doses severe hypertension was diagnosed by systolic blood pressure ≥160 mmhg and diastolic blood pressure ≥110 mmhg. mean arterial blood pressure ≥ 127 mmhg exclusion criteria: 1. patient refusal. 2. eclampsia 3. emenant eclampsia 4. hellp syndrome 5. chronic hypertension 6. patients who have chronic obstructive pulmonary disease. 7. patient with acute or chronic liver failure. 8. known allergy to the study medications
the instant effect of rigid and kinesio taping techniques in stroke individuals with foot drop

Conditions: Physical Performance, Gait and Physiological Expenditure Index in Stroke Patients

Summary: stroke individuals with foot drop experience poor physical performance and walking problems. physiological energy consumption also increases due to balance and walking problems. the aim of this study is to investigate the immediate effects of rigid and kinesio taping techniques on physical performance, gait and physiological expenditure index in stroke individuals with foot drop, and also to examine whether these approaches are superior to each other. as a result of this study, it was seen that rigid taping and kinesio taping were effective in stroke individuals with foot drop. when we compared the groups, it was determined that both taping methods produced similar effects.

stroke individuals with foot drop experience poor physical performance and walking problems. physiological energy consumption also increases due to balance and walking problems. the aim of this study is to investigate the immediate effects of rigid and kinesio taping techniques on physical performance, gait and physiological expenditure index in stroke individuals with foot drop, and also to examine whether these approaches are superior to each other. 40 individuals diagnosed with hemorrhagic or ischemic stroke were included in the study. individuals were divided into two groups: rigid taping group (n=20) and kinesio taping group (n=20). the physical performances of the individuals participating in the study were evaluated with the one-leg standing test, timed up and go test (tug) and the sit-up-from-chair test (suct), their walking speed was evaluated with the 10 meter walk test, and the spatiotemporal characteristics of the gait were evaluated with gait analysis on powdered ground. physiological expenditure index (fhi) was calculated with 6 minute walk test (6mwt) results. evaluations were recorded by the same physiotherapist before and after taping. as a result of this study, it was seen that rigid taping and kinesio taping were effective in stroke individuals with foot drop. when we compared the groups, it was determined that both taping methods produced similar effects. we believe that adding rigid or kinesio taping applications for foot drop to the rehabilitation program of stroke individuals with drop foot will increase the success of the treatment.

Eligibility criteria:
being diagnosed with ischemic or hemorrhagic stroke, not having cooperation and communication problems, stroke individuals with foot drop and those with a mas score of 2 or less, those who score 0-3 on the modified rankin scale.

Keywords: rigid taping kinesio taping drop foot gait stroke
effectiveness of a motivational interviewing-based intervention from pregnancy to 2 years of age.

Conditions: Childhood Obesity Prevention

Summary: the main objective of this study is to evaluate the effect of an early and intensive intervention, based on techniques of effective counseling on healthy habits for parents, in order to reduce mean bmi at 2 years of age secondly, the investigators will analyze the weighted increase of children's bmi, the eating habits of parents and children, duration of breastfeeding, physical activity level of parents and children and the children sleeping habits. in order to achieve it, the investigators have developed a randomized trial by primary care centers, controlled by two parallel groups of study, open and multicenter study. the investigator team will recruit 414 pregnant women bwtween 12 and 16 weeks of gestation who will or will not receive an intervention, depending on their primary care centers. the investigators will develop an intervention for parents, based on effective counseling techniques which are grounded on motivational interviewing approach with the objective of transmitting habits to reach a healthy lifestyle. the intervention consists in six workshops (90 minutes long), two prenatal and four postnatal, directed by professionals of the field researchers basic group (family practitioners, pediatricians, nurses and midwives). previously the field researchers will receive specialized training. this intervention will be compared to the usual model of care for children and women.


Eligibility criteria:
inclusion criteria: will be included all pregnant women who have given their consent and who meet the following inclusion criteria: * attended in primary care centers and not planning to change their place of residence in the period covered by the study. * women over 18 years of age. * gestational age between 12 and 16 weeks. * women whose pregnancy is liable of follow-up in primary care. exclusion criteria: * women who cannot communicate in spanish. * women with metabolic diseases that modify their weight (diabetes, hypothyroidism, hyperthyroidism, etc.). * maternal history of a serious medical or psychiatric illness or drug or alcohol abuse. * multiple pregnancy.

Keywords: obesity children pregnancy motivational interview family care primary care
ibd shared decision making intervention

Conditions: Inflammatory Bowel Diseases

Summary: the purpose of this clinical trial is to implement a multi-component shared decision making intervention for families of children with ibd. the main objective of this research will be to assess the acceptability, feasibility and clinical and decision outcomes of a multi-component decision support intervention targeted at families of children with ibd who are making decisions about treatment with tnfαi agents.

research has shown that when making decisions about treatment with anti-tumor necrosis factor-α (tnfαi) agents, parents of children with inflammatory bowel disease (ibd) experience high levels of decisional conflict. this extreme level of conflict is due to the challenge of considering an effective treatment that has potentially serious side-effects. elevated levels of decisional conflict have been associated with delays in decision making and failures to implement treatment plans. given that such delays may lead to worse clinical outcomes, there is an urgent need to improve the decision-making process around tnfαi therapy. the use of structured decision support to help inform and guide parents through this challenging decision may improve the decision-making process. such structure facilitates high-quality decision making by providing balanced, accurate information, helping individuals clarify what is most important to them, and facilitating conversations between families and healthcare providers. based the investigators' prior research into the tnfαi decision process, the investigators developed a multi-component decision support intervention designed to improve the tnfαi decision process. this intervention will be tested in a controlled pilot trial designed to assess the acceptability and feasibility of a multi-component intervention and to determine the effect size of the multi-component intervention on both clinical and decision outcomes in children and adolescents with ibd and their parents.

Eligibility criteria:
inclusion criteria: * clinician anticipates discussing tnfai treatment at clinic visit; parent and patient willing to have visit video-recorded exclusion criteria: * patient over age 17; prior use of tnfai; unable to read and speak english; clinic visit not conducted in english; previous participation in this study; known major mental illness in parent or adolescent patient; medical instability at scheduled visit; patient's gastroenterologist is a study investigator

Keywords: shared decision making
intralesional cryosurgery for basal cell carcinoma - a feasibility study

Conditions: Basal Cell Carcinoma (BCC)

Summary: a feasibility study for the treatment of basal cell carcinoma of the lower extremities in the elderly utilizing intralesional cryosurgery. 10 cases of bcc (confirmed by biopsy) in the lower extremity of elderly will undergo intralesional cryotherapy. a cryoneedle is introduced through the skin lesion (bcc) and thus the bcc is frozen. treatment success will be determined according to biopsy results 3 months after treatment

bcc is the most common skin cancer. many treatment modalities are acceptable including cryotherapy - freezing of the skin lesion with liquid nitrogen. this method is highly effective for the treatment of bcc. the purpose of this study is to determine the cure rates of bcc utilizing intralesional cryotherapy. surgery in the gold standard for the treatment of bcc, however in the case of skin malignancy in the elderly and in the lower extremity, surgical complication (including skin grafting) are high. therefore cryotherapy which is a non surgical treatment method provides an optimal therapeutic choice. 10 cases of bcc (confirmed by biopsy) in the lower extremity of elderly will undergo intralesional cryotherapy. a cryoneedle is introduced through the skin lesion and the bcc is frozen. treatment success will be determined according to biopsy results 3 months after treatment. participants will be followed at the out patient clinic for the duration of wound healing, an expected average duration of 3 weeks.

Eligibility criteria:
inclusion criteria: * patients over 60 years old * bcc was determined with tissue diagnosis in the lower extremity * one or more risk factor for surgical complication including: diabetes, venous insufficiency, obesity, peripheral vascular disease, lymphedema and long term steroids use. exclusion criteria: * patient unable to read, understand and sign the consent form

Keywords: basal cell carcinoma (bcc) cryotherapy cryosurgery
comparison of different methods to calculate pendelluft by electrical impedance tomography in mechanically ventilated patients

Conditions: Asynchrony, Patient-Ventilator; ARDS; Respiratory Insufficiency; Respiratory Effort-Related Arousal &#X7C; Patient &#X7C; Respiratory Measures and Ventilator Management

Summary: the pendelluft phenomenon is an important cause of lung damage in spontaneously breathing mechanically ventilated patients since it considerably increases the stress on the lung parenchyma in the dependent areas. it can result in a local driving pressure up to three times higher than the global driving pressure. the measurement of pendelluft is still uncertain in the literature, and although various methods have been proposed, not all have the same meaning in terms of pulmonary overstress and overstrain. this study proposes a comparative analysis of different ways to calculate and estimate the stress imposed on the lung parenchyma by pendelluft in terms of regional volume and local driving pressure through electrical impedance tomography.

respiratory mechanics and regional ventilation will be monitored by electrical impedance tomography (enlight 1800 and 2100, timpel). esophageal and gastric pressures will be obtained by placing an esophageal/gastric balloon cathether (nutrivent ®), validation concerning position will be done through modified baydur maneuver (delta esophageal/delta airway pressure = 0.8-1.2). the hardware pneumodrive will be used to inflate the balloon and store the airway, gastric and esophageal pressures. initially the patients will be monitored with eit for aproximately 30 minutes after pletismography stabilization. then, an arterial blood-gas sample shall be collected for analysis. next, three expiratory and three inspiratory pauses of at least two seconds will be realized with intervals of eight respiratory cycles between them, allowing plateau pressure to be recorded and global and regional driving pressure to be estimated. all this data will be stored for later analysis. the same procedures and measurements shall be made sequentially with a 50% higher pressure support and with a 50% lower pressure support.

Eligibility criteria:
inclusion criteria: * patients under invasive mechanical ventilation intubated due to respiratory failure in pressure support mode (weaning phase) exclusion criteria: * age less than 18 years; sedation or neuromuscular blockade; absence of respiratory effort; contraindications to esophageal balloon cathether positioning or electrical impedance tomography belt positioning; presence of pneumothorax or active air leaks; hemodynamic instability; absence of informed consent.

Keywords: pendelluft ventilator-patient asynchrony patient self-induced lung injury ards respiratory failure electrical impedance tomography
efficacy of dry needling in cervical pain

Conditions: Cervical Pain

Summary: the presence of latent myofascial trigger points (mtrps) in the angular muscle of the scapula is one of the possible causes of non-specific neck pain. dry needling (dn) and ischaemic compression (ic) techniques may be useful for the treatment of these mtrps. methods: 80 participants were divided into two groups: the dry needling group, which received a single session of dn on the angular muscle plus hyperalgesia (n=40), and the ic group, which received a single session of ic on the angular muscle plus hyperalgesia (n=40). pain intensity, pain pressure threshold (ppt), range of motion (rom) and quality of life were assessed at baseline, immediately after, 48 hours and one week after treatment.


Eligibility criteria:
inclusion criteria: * patients presenting with neck pain * patients presenting with trigger point activation of the angularis scapulae muscle exclusion criteria: * patients who have an absolute fear of needles (belonephobia). * patients presenting with cervical pain with radiculopathy or irradiation of pain to the upper limb.

Keywords: dry needling physiotherapy techniques cervical pain pain
anti-psoriatic effect of tl01 light therapy

Conditions: Psoriasis

Summary: this is a pilot study to investigate the effect of tl01 narrow band uvb therapy on the resident dermal dendritic cells characterized by expression of cd1c and cd141. these cells were reported to have a role in induction of tolerogenic regulatory t cells and production of il-10. the investigators proposed to investigate the effect of nb-uvb on these subsets of cells after two weeks of treatment to provide better understanding of the mechanism of action of light treatment.

six patients with plaque psoriasis were recruited from the phototherapy unit. these patients were referred by their dermatologist to receive narrow-band uvb (tl01) light treatment. two 6 mm lesional skin punch biopsies were taken at baseline and 2 weeks after commencing the light treatment to study the effect of light on innate immune cells involved in psoriasis pathogenesis.

Eligibility criteria:
inclusion criteria: * male and female psoriasis patients in whom the decision to treat with nb-uvb therapy, as part of their routine clinical care, has been taken by their dermatologist in the age range of 18-70 years. exclusion criteria: * patients currently on antipsoriatic treatment. * patients with immunosuppressive diseases * patients on immunosuppressive therapies * pregnant or lactating female patients * patients unable to provide a written consentprocedure

Keywords: psoriasis patients referred to receive tl01 nb-uvb therapy