Kornimate/medical-research-clean huggingface dataset:
captain sonar impact on trauma patient management

Conditions: Trauma Injury

Summary: trauma patient care requires collaboration and interaction with close relationship between many stakeholders from different professions (senior doctor, intern, nurse, nurse helpers, surgeons, etc). this is a stressful situation where decision and action need to be quick, decisive and coordinate. in this situation, quality of care and patient safety depends on a good interprofessional communication. the acquisition of advanced communication skills, team management and leadership, stress management are essentials elements in the practice of intensive and trauma care. however, advanced structured training or assessment of theses skills is lacking in medical education or healthcare professionals training. the study therefore, aimed to develop a global and attractive training to help healthcare professionals to improve their skills. captain sonartm is a naval battle game where two teams each composed of four participants clash. each player has a well-defined role and it is imperative to communicate in a closed loop to advance in the game. this game also includes components similar to support for shock management: stress, speed of action, central communication and teamwork of four protagonists (team leader-captain, intern-second, nurse-mechanic, nurse help-detector). it may improve team building, team leadership, interprofessional work, communication, stress management. the study hypothesis is that this board game would have an impact on the performance of professionals when facing a multiple trauma simulated patient. (differences in terms of technical and non-technical performance. different use of closed loop communication, different stress management, different efficiency and interprofessional collaboration with potentially a reduction in the timing of treatment being delivered in trauma room)

all the teams of 4 participants and 1 medical student previously trained will then benefit from a training session either exposed to captain sonar or into the control arm with monopoly. high-fidelity and multiprofessional simulation session based on the incoming of a severe traumatized patient will be held. these sessions will take place on high-fidelity mannequins lent by the cless (lyonnais center for health simulation education) in pavilion h of édouard herriot hospital, within the trauma center (in situ). the same scenario will be presented for all groups (exposed and controls) with the same objectives of realization and the same complexity. an audio-visual recording will take place during each session in order to allow the evaluation of the study criteria on technical and non technical skills between the participants a posteriori of the simulation session.

Eligibility criteria:
inclusion criteria: professional working at the unit exclusion criteria: none

Keywords: healthcare professionals technical skills non technical skills crew ressource management stress evaluation and management
prevalence and risk factors for coxiella burnetii seropositivity (q fever) among adults in western france

Conditions: Q Fever

Summary: diseases naturally transmitted between animals and humans (zoonoses) are one of the leading causes of emergence or re-emergence of human infectious diseases. non-foodborne zoonoses are commonly transmitted to human directly by contact with infected animals or contaminated environment. people working with animals such as farmers and veterinarians are particularly at risk of infection. some zoonoses can also be transmitted indirectly thought the air and therefore can affect the general population. example is q fever, a disease caused by coxiella burnetii, a bacterium highly resistant in the environment. in western france, q fever is endemic in cattle herds. to improve human zoonotic disease surveillance, the investigators will conduct a population based study in this area. the aims of the study are: 1. to assess seroprevalence of coxiella burnetii infection among general population, farmers and veterinarians in western france 2. to identify risk factors for coxiella burnetii seropositivity in these populations

in order to estimate seroprevalence and risk factors for coxiella burnetii infection in humans, the investigators will conduct a cross-sectional study in three groups: * blood donors at blood donation organizations (general population) * beef and dairy cattle farmers * veterinarians involved in a rural practice all the participants in the study will provide a blood sample and will fill in a questionnaire.

Eligibility criteria:
inclusion criteria: * give a written informed consent * be 18 years old and over * be able to speak french exclusion criteria: * adults under protection (guardianship or curators) * contraindication for drawing blood
more air - better performance - faster recovery

Conditions: Functional Independence; Respiratory Insufficiency

Summary: the objective of this study is to investigate i) the effect of 3 weeks imt to adults post-stroke to maximal inspiratory pressure (mip) and ii) the effects of 3 weeks imt to the degree of dependency in activities of daily living, endurance in gait, fatigue, voice volume, phonation endurance, and expiratory function. methods/design: randomised controlled trial (rct) comparing imt to conventional neurorehabilitation (usual practise). 80 patients, with reduced maximal inspiration pressure (mip) hospitalized at a specialized neurorehabilitation hospital in denmark will be included.

background: stroke results in varying disabilities physical, cognitive, emotional and/or social both in short term and long term. motor impairments are significantly persistent consequences post-stroke among these are decreased respiratory muscle function, decreased ability to expand thorax and postural dysfunction. these deficits influence the patient's ability in daily activities, fatigue, endurance and quality of life. inspiratory muscle training (imt) is training to improve the strength and endurance of diaphragm and the external intercostal muscles. the objective of this study is to investigate i) the effect of 3 weeks imt to adults post-stroke to maximal inspiratory pressure (mip) and ii) the effects of 3 weeks imt to the degree of dependency in activities of daily living, endurance in gait, fatigue, voice volume, phonation endurance, and expiratory function. methods/design: randomised controlled trial (rct) comparing imt to conventional neurorehabilitation (usual practise). 80 patients, with reduced maximal inspiration pressure (mip) hospitalized at a specialized neurorehabilitation hospital in denmark will be included. the intervention group will add-on imt sessions exercising at 30 % of mip. patients in the intervention group perform 2 sessions a day (one session of imt with imt threshold flute consists of 2 times 15 inspirations in normal breathing rhythm (5-10 min)), 7 days a week for 3 weeks. training can be with or without supervision of physiotherapist.

Eligibility criteria:
inclusion criteria: * first time brain infarction or brain haemorrhage 0-6 month. * able to give written consent and being cognitive and communicative able to understand and participate in the maximal inspiration pressure test (mip) * reduced mip below gender and age specific normal standard exclusion criteria: * diagnosis of myocardial infarction within the last 3 months * significant pulmonary disease (severe copd), saturation below 90 if having copd for others saturation below 92 * neurological deficits other than stroke * facial palsy that affects proper labial occlusion * dizziness or nausea/vomiting during mip-testing.

Keywords: stroke, functioning fatigue voice volume
reco in the endovascular treatment of acute ischemic stroke

Conditions: Intracranial Artery Occlusion With Infarction (Disorder)

Summary: investigate reco ® ,the first clot retriever in china as the primary therapyand remedies in the real world.

endovascular thrombectomy (evt) is effective and safe for acute ischemic stroke (ais) caused by large vessel occlusion (lvo) in major clinical trials. whether the benefit of evt in randomized trials could be generalized to clinical practice, especially in developing countries, remains unknown. the registry was established to evaluate the utilization, and subsequent outcomes of evt treated ais patients. this study is a multi-center, prospective registry study initiated by researchers, to investigate reco ® ,the first clot retriever in china as the primary therapyand remedies in the real world.

Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years old 2. diagnosis of acute ischemic stroke 3. imaging confirmed intracranial large artery occlusion (lvo): intracranial internal carotid artery (ica t/l), middle cerebral artery (mca m1/m2), anterior cerebral artery (aca a1/a2), basilar artery (ba), vertebral artery (va v4), and posterior cerebral artery (pca p1);aspect or pc-aspect ≥ 6 4. initiation of any type of endovascular treatment (evt), including intra-arterial thrombolysis, mechanical thrombectomy, angioplasty, and stenting 5. the patient or the patient's legal representative is able and willing to sign the informed consent exclusion criteria: 1. isolated cervical ica or va occlusion; 2. no evidence of lvo on dsa.

Keywords: acute ischemic stroke endovascular treatment registry
efﬁcacy and safety of weight-based insulin titration regimen in hospitalized patients with type 2 diabetes

Conditions: Efficacy, Self; Adverse Effect

Summary: the investigators propose to use a weight-based regimen consisting of basal-bolus insulin and preprandial rapid-acting insulin and to test its efficacy and safety in controlling blood glucose in hospitalized patients with type 2 diabetes.

patients with type 2 diabetes are randomly assigned by computer-generated block randomization to receive either weight-based or glucose level-based titration regimen. all antidiabetic drugs are discontinued on admission. starting dose: total daily insulin is 0.4u/kg. half is given as glargine and the remainder as aspart which is divided into three equal parts used for three pre-meal boluses. titration: 1. weight-based insulin titration regimen: glargine titration: 0.1u/kg per day when fasting blood glucose (fbg) is over 8.0 mmol/l. aspart titration: total dose 0.1u/kg per day when next pre-meal blood glucose (bg) is over 8.0 mmol/l, which is divided into three equal parts adding to three pre-meal boluses. 2. glucose level- based titration regimen: glargine titration: 4, 6, or 8 u when fbg is, respectively, within the following ranges: 8.0-8.9, 9.0-9.9, \>10.0 mmol/l. aspart titration: 1, 3, 5, 7 or 8 u when next pre-meal bg is, respectively, within the following ranges: 8.0-10.9, 11.0-13.9, 14.0-16.9, 17.0-19.9, \> 20 mmol/l.

Eligibility criteria:
inclusion criteria: * patients aged 18 to 80 years with type 2 diabetes admitted to endocrinology wards. exclusion criteria: * patients with hepatic or renal dysfunction, cancer, or diabetic ketoacidosis; * patients who are pregnant or lactating.

Keywords: insulin type 2 diabetes
short terms effects of medial branch block vs para-spinal muscle injection in patients with non-specific clbp

Conditions: Low Back Pain, Mechanical

Summary: this study compares the efficacy of medial branch block (mbb) vs. paravertebral deep intramuscular (pdi) injection for pain relief in chronic low back pain. based on randomization in first intervention session, one side receives mbb and the other side takes pdi and in second session the pattern reverses.

pain relief following medial branch block (mbb) might be due to facet joints desensitization and/or myofascial trigger points' desensitization. patients will be randomized to two groups. the first group receives mbb in one side and paravertebral deep intramuscular (pdi) injection in the other side of the back. next week the pattern of injection will be reversed so the side which had received mbb will take pdi injection and pdi side will take mbb. second group takes the intervention in reverse order.

Eligibility criteria:
inclusion criteria: * clbp of non-malignant origin fulfilling the following criteria: * pain lasting for at least three months * pain in both the left and right sides of the back * pain below the l2 vertebral body * lumbar spine ct scan or mri done in the last 2 years * average visual analogue scale (vas) for pain ≥4/10 on each side for the 3 days * cognitive and physical ability to provide informed consent in english or french exclusion criteria: * neurologic signs or symptoms suggesting nerve root involvement * strictly unilateral low back pain (lbp) * ct scan or mri findings suggestive of pain etiology beyond degenerative spine disease * vascular malformations * tumor * infection * fractures * dish (diffuse idiopathic skeletal hyperostosis) * patients who have received injections of any type or acupuncture therapy to the low back in the last 3 months * prior spine surgery * local or systemic infection * bleeding disorder or the use of anticoagulation medications but for low-dose aspirin * known allergy to amid local anesthetics * active insurance claim (csst, saaq) * uncontrolled psychiatric condition

Keywords: facet induced pain myofascial pain trigger points low back pain
perioperative continuous glucose monitoring in patients undergoing an abdominal surgery

Conditions: Diabetes Mellitus; Prediabetes

Summary: the purpose of this study it to assess whether the continuous glucose monitor system dexcom g6® can be reliably used for perioperative glucose monitoring in 20 prediabetic or diabetic patients undergoing abdominal surgery in terms of data continuity, accuracy and patient tolerability.

the current recommended method for monitoring glucose control is bedside point of care capillary blood glucose testing. a significant limitation for this method is the frequency by which blood glucose testing is typically performed, at most 4-6 times daily. continuous glucose monitoring (cgm) provides an alternative approach to measure glucose values with the advantage of greater frequency of monitoring as it is measured every few minutes. whilst cgm use in the outpatient setting is rising and has demonstrated benefits on glycaemic control, the accuracy of these devices perioperatively is less investigated. in this study the sixth-generation factory-calibrated real-time dexcom g6® system will be used as a cgm and its glucose values perioperatively will be compared to the capillary glucose values which will be measured simultaneously by the accu-check inform ii (roche diagnostics) point-of-care blood glucose meter. the investigators aim to assess the feasibility and accuracy of perioperative cgm.

Eligibility criteria:
inclusion criteria: * aged ≥18 years * pre-diabetic (hba1c 5.7-6.5%) or diabetic (regardless of aetiology) * scheduled to have elective abdominal surgery at the university hospital bern * surgery duration \>2 hours exclusion criteria: * planned mri procedure during hospitalization * inability to follow procedures * incapacity to give informed consent * presence of extensive skin abnormalities at the sensor insertion site (upper arm) * known allergic/irritative skin reactions to dressings/adhesives * haematocrit values outside the normal range * patients with immunosuppression defined as neutrophil count \<0.5x10\^9/l * patients on isolation precautions (contact, droplet, airborne) * pregnancy or breast-feeding

Keywords: perioperative glucose management continuous glucose monitoring diabetes
short-term low-dose interferon alfa in treating patients with cancer of the urothelium

Conditions: Bladder Cancer; Urethral Cancer

Summary: rationale: interferon alfa may interfere with the growth of tumor cells and slow the growth of urothelial cancer. purpose: this randomized phase i trial is studying how well low-dose interferon alfa works in treating patients with cancer of the urothelium.

objectives: * determine the modulation of apoptosis-related pathways in patients with cancer of the urothelium treated with short-term low-dose interferon alfa. outline: this is a randomized study. patients are randomized to 1 of 4 treatment arms. in all arms, treatment begins at the time of the pre-operative visit and continues until the time of cystoscopy. * arm i: patients receive low-dose interferon alfa subcutaneously (sc) twice daily. * arm ii: patients receive interferon alfa as in arm i at a higher dose. * arm iii: patients receive interferon alfa sc once daily. * arm iv: patients receive interferon alfa as in arm iii at a higher dose. in all arms, treatment continues in the absence of unacceptable toxicity. projected accrual: approximately 30 patients will be accrued for this study.

Eligibility criteria:
inclusion criteria: 1. patients must have histologically proven urothelial cancer, known or suspected (e.g. by outside evaluation) to be muscle-invasive, and be scheduled for cystoscopy and transurethral biopsy as part of their routine evaluation at m. d. anderson. 2. patients must understand the investigational nature of this study and provide written, informed consent. exclusion criteria: 1. patients who are pregnant or lactating are not eligible. women of child-bearing potential must have a negative pregnancy test before starting therapy. 2. patients with current symptoms suggestive of clinically significant affective disorder. 3. patients taking more than physiologic replacement doses of corticosteroids are not eligible.

Keywords: stage ii bladder cancer stage iii bladder cancer stage iv bladder cancer localized transitional cell cancer of the renal pelvis and ureter regional transitional cell cancer of the renal pelvis and ureter metastatic transitional cell cancer of the renal pelvis and ureter anterior urethral cancer posterior urethral cancer urethral cancer associated with invasive bladder cancer
way to be active iii (framing incentives)

Conditions: Sedentary Lifestyle

Summary: employers are increasingly looking for opportunities to motivate sedentary employees to become more physically active. workplace walking programs have had mixed success and typically show most improvement among participants that are already fairly active at a baseline. the goal of this study is to determine whether a financial incentive program can motivate sedentary employees to increase the number of steps they walk per day to meet a minimum threshold. the primary outcome measure is the proportion of days a minimum activity of 7000 steps or more is achieved. outcomes will be assessed each week for 3 months using incentives followed by 3 months of follow-up without incentives. secondary outcomes will include the average steps walked per day.


Eligibility criteria:
inclusion criteria: 1. age greater than 18. 2. participant will need an iphone or android smartphone to be able to use the moves app for tracking steps exclusion criteria: 1. a score of "high" on the international physical activity questionnaire (ipaq) activity level scale 2. bmi less than 27 3. pregnant or lactating 4. participation in another physical activity study

Keywords: sedentary lifestyle pedometers obesity physical activity financial incentives behavioral economics
characteristics and outcome of patients with covid-19 in icus in south tyrol

Conditions: COVID-19; COVID-19 Acute Respiratory Distress Syndrome

Summary: the investigators retrospectively investigate the epidemiology, clinical characteristics and therapeutic interventions of patients with covid-19 associated respiratory failure admitted to the intensive care units in south tyrol, italy.

in this observational, retrospective study the epidemiology, characteristics, therapeutic interventions and outcome of patients with covid-19 associated respiratory failure admitted to the intensive care units in south tyrol, italy, are assessed. data extracted from the medical patients' records include type and duration of respiratory support (high-flow nasal oxygen, non-invasive ventilation, invasive ventilation), need for tracheostomy, vasopressor needs, antibiotic therapy, corticosteroid treatment, laboratory values (interleukin-6, c-reactive protein, procalcitonin, d-dimer, lymphocyte count), lengths of stay in the icu and mortality.

Eligibility criteria:
inclusion criteria: * all patients admitted to the intensive care units in south tyrol due to covid-19 associated respiratory failure exclusion criteria: * sars-cov-2 patients admitted to the intensive care units in south tyrol for other pathologies (i.e., not respiratory failure)
safety and tolerability study of k0706 in subjects with parkinson's disease

Conditions: Parkinson Disease

Summary: this is a safety, tolerability and pharmacokinetic study in subjects with parkinson's disease


Eligibility criteria:
inclusion criteria: 1. willing and able to give written, and dated, informed consent (or legally acceptable representative/impartial witness when applicable) and is available for the entire study 2. willing and able to comply with the scheduled visits, treatment plan, laboratory testing, study procedures, and restrictions (in the investigator's opinion), and be accessible for follow-up 3. male or female aged 18 to 65 years (both inclusive) 4. diagnosed with parkinson's disease exclusion criteria: 1. clinical diagnosis of genetic form of parkinson's disease, or drug-induced parkinsonism 2. diagnosis of parkinson's disease dementia (probable, possible) 3. presence of severe dyskinesias 4. history of brain surgery for parkinson's disease
comparison of nph insulin and insulin detemir in children and adolescents with type 1 diabetes

Conditions: Diabetes; Diabetes Mellitus, Type 1

Summary: this trial is conducted in europe. the aim of this research is to compare the efficacy and safety of treatment with nph insulin and insulin detemir. you will be treated with either insulin detemir or nph insulin once or twice daily as basal insulin. additionally you will receive insulin aspart as bolus insulin


Eligibility criteria:
inclusion criteria: * insulin detemir naive * type 1 diabetes for at least 12 months * hba1c lesser than or equal to 11.0% exclusion criteria: * significant concomitant diseases
changes of the hemodynamic profiles on bio reactance technique during turp in elderly patients

Conditions: Benign Prostate Hyperplasia

Summary: the purpose of this study is to evaluate the change of the hemodynamic profiles on bio reactance technique during turp in elderly patients.


Eligibility criteria:
inclusion criteria: 1) twenty (asa status i \~ iii) patients, ages 65 to 80 yr old, who were scheduled for transurethral resection of the prostate under spinal anesthesia exclusion criteria: 1. if there were contraindications for spinal anesthesia including hypersensitivity to any local anaesthetics, bleeding diathesis, infections at the puncture sites, or pre-existing neurological disease. 2. history of coronary artery bypass surgery 3. history of dementia 4. have a difficulty in understanding informed consent or refuse to sign the informed consent 5. patients height under 150 cm

Keywords: elderly patient nicom turp