Kornimate/medical-research-clean huggingface dataset:
study to evaluate the efficacy of pre-operative administration of etoricoxib 120 mg, etoricoxib 120 mg and paracetamol 1 g combination or placebo in the treatment of postoperative pain in patients undergoing gynaecologic laparoscopic surgery

Conditions: Pain

Summary: primary hypothesis: 1. the analgesic effect of etoricoxib 120 mg administered 1 hour preoperatively is greater than that of placebo in the treatment of postoperative pain.


Eligibility criteria:
inclusion criteria: 1. type of gynaecologic surgery: * diagnostic laparoscopy * sterilization * removal of ovarial cyst * chromopertubation * laparoscopic myomectomy * laparoscopic fenestration of ovaria * laparoscopic adhesiolysis 2. age 18-50 years. 3. evaluated risk of anaesthetic procedure according to asa (american society of anaesthesiologist) classification: asa i or ii. 4. patients agreed to participate in the study and signed the informed consent. exclusion criteria: 1. asa iii or more 2. emergency surgery 3. major laparoscopic surgery i.e. hysterectomy 4. duration of surgery more than 90 minutes 5. chronic pain 6. history of hypersensitivity to the active substance or to any of the excipients of study drug (paracetamol or etoricoxib) 7. active peptic ulceration or active gastro-intestinal (gi) bleeding. 8. patients who have experienced bronchospasm, acute rhinitis, nasal polyps, angioneurotic oedema, urticaria, or allergic-type reactions after taking acetylsalicylic acid or nsaids including cox-2 (cyclooxygenase-2) inhibitors. 9. pregnancy and lactation 10. severe hepatic dysfunction (serum albumin \< 25 g/l or child-pugh score ≥ 10). 11. estimated renal creatinine clearance \< 30 ml/min. 12. children and adolescents under 16 years of age. 13. inflammatory bowel disease. 14. congestive heart failure (nyha ii-iv). 15. patients with hypertension whose blood pressure has not been adequately controlled. 16. established ischaemic heart disease, peripheral arterial disease, and/or cerebrovascular disease, unstable angina. 17. patient has undergone coronary artery bypass graft surgery, angioplasty, or had myocardial infarction, cerebrovascular accident or transient ischemic attack within the past 6 months. 18. history of drug abuse.

Keywords: preoperative pain prophylaxis postoperative pain
12 lead ecg database

Conditions: Arrhythmias, Cardiac

Summary: the purpose of this investigation is to collect a database of simultaneous electrocardiogram (ecg) recordings from the sansa device and a reference 12-lead ecg recording device. the purpose of this database is to aid development and evaluation of algorithms to detect cardiac arrhythmias and other parameters from the electrocardiogram. example analyses that may utilize this database are ecg vector transformations and ecg waveform timing analyses. the study is for scientific purposes and does not intend to diagnose, cure, mitigate, treat, or prevent any disease and does not involve any medical procedures.


Eligibility criteria:
inclusion criteria: * are 18 years of age or older. * are able to read, understand, and sign informed consent documentation. * are willing to undergo simultaneous recordings with the sansa and 12-lead ecg device. exclusion criteria: * exhibit deformities of the chest (e.g., pronounced scarring, pectus carinatum) that would interfere with sensor placement * have broken or injured skin that would interfere with sensor placement * are known to experience adverse reactions to medical-grade adhesive * are pregnant
clinical and social trajectories of children and adolescents with disruptive behavior

Conditions: Disruptive Behavior Disorder

Summary: conduct disorders are defined as "repetitive and persistent pattern of behavior in which the basic rights of others or major age-appropriate norms are violated". so defined, these disorders are at the crossroads of psychiatry, social field and justice. conduct disorder management is a public health issue and a societal question. conduct disorders affect 5 to 9% of 15-year old boys. care management of children and adolescents admitted for disruptive behaviors in emergency rooms is an issue. no consensus or official recommendation exists. however, use of emergency care in this context is increasing in most western countries and it exposes to several risks (inappropriate use of hospitalizations, social rupture, ignorance of comorbidities and suicide risk). the trajectories project is designed to describe children and adolescents with disruptive behaviors, their care management and to follow their life trajectory and psychiatric evolution after admission to emergency rooms. better understanding this population will improve their medical and social care management, thereby giving professionals the right tools. the main objective of this project is to implement a multidisciplinary and integrative research combining clinical considerations and social sciences to determine the "trajectory" of this population.


Eligibility criteria:
inclusion criteria: * children and adolescents less than 16 years old * children and adolescents admitted to emergency rooms for aggressiveness, violence, fugue or theft exclusion criteria: * children and adolescents admitted to emergency rooms for a reason not directly link with aggressiveness, violence, fugue or theft * opposition to the subject or the family to participate to this research

Keywords: trajectories emergency room conduct disorder care management
sleep disturbances and pulmonary artery/aorta diameter in scleroderma patient

Conditions: Scleroderma; Pulmonary Hypertension

Summary: to determine sleep disturbance, pulmonary function test, 6 minute walk, echocardiogram abnormality, arterial blood gas, ventilation/perfusion scan of the chest in scleroderma patient with pulmonary hypertension.

as above

Eligibility criteria:
inclusion criteria: * patient must have scleroderma exclusion criteria: * patients who do not have scleroderma

Keywords: scleroderma pulmonary hypertension
volatil organic compounds in exhaled air and sweat after thoracic surgery for carcinological resection

Conditions: Lung Cancer, Non-small Cell

Summary: bronchopulmonary cancer, with 39 000 new cases and 30 000 deaths per year, is a main issue in public health in france. it is the leading cause of cancer death in france. a lot of progress in medical care has been made, but surgery remains the most effective treatment, when it is still possible. the goal is to detect and manage the lung cancer as early as possible. alongside screening strategies by annual thoracic scanner, new approaches with innovative technologies open up for cancer detection and therapeutic follow-up. the study of volatile organic compounds (voc) detected in exhaled air or in sweat, is an innovative research area for respiratory diseases. the volatolomic analysis can be done either by the technique of the mass spectrometry which allows the identification of each voc in the exhaled air or by the technique of electronic nose, simpler and faster, which provides an idea of the general profile of the voc without identifying them. the voc have shown their interest in some situations, such as diagnostic or prognostic tool in patients followed for thoracic tumorous pathology or bronchial or pulmonary vascular diseases. the composition of voc in exhaled air and sweat is altered in patients with lung cancer. the voc analysis and their variation could be used particularly in the follow-up of patients treated for lung cancer. the purpose of this clinical research is to identify the vocs related to lung cancers by comparing the voc profiles in exhaled air and in sweat from patients diagnosed with localized lung cancer before and after resection surgery.


Eligibility criteria:
inclusion criteria: * patient aged ≥ 18 years old * patient with non-small cell lung cancer * operable grade i or ii * no specific treatment before surgery (radiotherapy, chemotherapy or targeted therapy) * patient with healthcare insurance non inclusion criteria: * treatment with radiotherapy, chemotherapy, or neoadjuvant cancer targeted therapy before thoracic surgery * patient with oxygen therapy or invasive ventilation * patient unable to perform a slow vital capacity * dermatological therapy interfering with sweat collection (psoriasis, irritant dermatitis, for instance) * pregnant women * patient deprived of liberty by judicial or administrative decision
a study of motexafin gadolinium for the treatment of relapsed or refractory multiple myeloma

Conditions: Multiple Myeloma

Summary: the purpose of the study is to determine if the drug motexafin gadolinium will be an effective treatment for patients who have relapsed or refractory multiple myeloma.


Eligibility criteria:
inclusion criteria: * relapsed or refractory multiple myeloma * ≥ 18 years old * able to provide consent for participation * ecog status 0-2 lab values: * anc ≥ 1,000/µl * wbc count ≥ 2.0/µl * hemoglobin ≥ 8.0 g/dl * platelet count ≥ 50,000/µl * ast and alt ≤ 2 x uln * total bilirubin ≤ 2 x uln * creatinine ≤ 2.0 mg/dl and * not pregnant or lactating

Keywords: myeloma multiple myeloma relapsed multiple myeloma refractory multiple myeloma
do the sppb and 4-metre gait speed predict hospital readmission in patients hospitalised for acute exacerbation if copd?

Conditions: Pulmonary Disease, Chronic Obstructive; Respiratory Tract Diseases; Lung Diseases; Lung Diseases, Obstructive; Bronchitis, Chronic; Pulmonary Emphysema; Disease Progression

Summary: this study aims to evaluate simple tests of physical function in hospitalised patients with chronic obstructive pulmonary disease (copd) and to assess whether they can predict future hospital readmission. the short physical performance battery (sppb) is a simple test of standing balance, usual walking speed (4-metre gait speed) and ability to stand from a chair, which reflects global physical functioning and frailty. we hypothesise that the sppb or 4-metre gait speed can predict future hospital readmissions.


Eligibility criteria:
inclusion criteria: * hospital admission with an exacerbation of copd * must have capacity to consent * able to walk exclusion criteria: * co-morbibities that limit walking ability * co-morbidities that make walking unsafe

Keywords: cohort studies longitudinal studies patient readmission hospitalization disability evaluation
prevalence of psoriasis alba in psoriatic patients

Conditions: Psoriasis

Summary: interdigital psoriasis (psoriasis alba) is atypical and rare form of psoriasis that is often missed as it is commonly mistaken for either dermatoses or fungal infection.in this study we observed and analyzed the prevalence of psoriasis interdigital of palms and soles and brought medical awareness to dermatologists and family doctors this rare form of psoriasis. thus, you can help to avoid mistaken diagnosis and the start of correct treatment as soon as possible.

hospitalized patients and outpatient clinic will be included in the study after receiving the signature of a inform consent.patients groups : 100 patients with psoriasis,100 patients with atopic dermatitis and 100 healthy patients (control group).patients with atopic dermatitis will be the secondary control group.patients diagnosed with inflammatory condition of interdigital skin of the palms and soles will be checked by fungal microscopy test.if the fungal test is negative ,we need to prepare to a biopsy of the skin in this area .following results of the skin biopsy conclusions can be shown about the prevalence of interdigital psoriasis in psoriatic patients enabling suitable treatment to be given to the patients.

Eligibility criteria:
inclusion criteria: * patients above 18 years old ,hebrew speakers, patients with psoriasis vulgaris or atopic dermatitis without systemic treatment exclusion criteria: * patients below 18 years old, pregnancy women, patients treated with systemic agents for psoriasis or atopic dermatitis(methotrexate,cyclosporin,neotigason)

Keywords: interdigital psoriasis (psoriasis alba)
intrathecal pump refill undergoing regular intrathecal pump refill

Conditions: Chronic Pain

Summary: reservoir fill port identification by palpation versus ultrasound,a mono-centre prospective comparison study in patients undergoing regular intrathecal pump refill

intrathecal drug therapy with implantable intrathecal pumps is being utilized increasingly for the treatment of chronic refractory pain and spasticity. however, performing the regular refill procedures of the pumps with the commonly performed "blind" technique caries the potential risk of medication injection into the subcutaneous tissue, which can lead to an overdose. objective: the primary purpose of this study is to assess the accuracy of the ultrasound-guided technique for the refill procedure compared to the blind technique in subjects undergoing regular refills of their intrathecal pumps for the treatment of chronic non-malignant pain or spasticity. study design: mono-center prospective efficacy and reliability study comparing two approaches to enter the fill port. study population: the investigators will include patients with an intrathecal pump for the treatment of chronic non-malignant pain or spasticity, undergoing regular refills of their intrathecal pumps at our centro terapia del dolore at the ospedale italiano a viganello(eoc, switzerland). intervention: two different experienced clinicians will perform one time the blind technique and two times the ultrasound-guided technique on all patients.sample size calculations can be performed. the sample size i.e. n=25 patients in nsi-td-001 protocol v. 1.0 final: august 4th, 2014 confidential page 31 of 40 total assessed 6 six times is therefore based on practical grounds related feasibility to duration of inclusion (i.e. one year). this would imply 50 paired assessments for both fill port accuracy assessment and intra-rater reliability. the investigators believe based on clinical experience that this number would suffice to detect a difference between methods. likewise, although no formal power calculation are available for icc based reliability assessment, as a rule of thumb 50 paired assessments are usually considered adequate to evaluate intra-rater liability.

Eligibility criteria:
inclusion criteria: * 18 years or older at the time of enrollment; * the patients are treated for chronic non-malignant pain or spasticity with an intrathecal * programmable infusion pump and undergo regular refills of their pumps in our clinic. * able to provide adequate given written, informed consent to participate in this study. exclusion criteria: * patient refusal to participate or provide informed consent standard exclusions; pregnancy, lactation, treatment with other investigational products. * other clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, * cardiovascular disease). * infection at the puncture site -participation in another study.-
patient-derived organoid model and circulating tumor cells for treatment response of lung cancer

Conditions: Lung Neoplasm

Summary: create a living biobank of pdos from stage i-iii lung cancer patients.

creation a living biobank of pdos from stage i-iv lung cancer patients (n=50). we selected enrollment of at least 50 patients so that they can be risk stratified based on lung tumor type, staging and we plan to store these pdos in biobank for future experiments. for each patient, tumor specimens will be collected at time of their surgery. no specific therapeutic intervention or treatment is provided as part of this study. 1. establishment and culture of pdos from lung cancer tumor specimens. pdos will be biobanked for future experiments. 2. lung organoids and ctcs will also be cultured and used to study baseline tumor characteristics using histology, immunohistochemistry, atomic force measurements; as well as, oncogenic signaling pathways and proteomic profile of lung organoids and ctcs derived from lung cancer patients (n\>50). 3. patient demographic information and data to be collected using a patient survey data sheet with treatment and survival history collected at pre-defined time period per the protocol schedule.

Eligibility criteria:
inclusion criteria: * read, consented to and signed the irb-approved informed consent form prior to any study related procedure. * diagnosis of lung cancer or lung mass or lymphadenopathy that will either systemic treatment or tumor resection as part of standard of care * any clinical stage of lung cancer * adult patients ≥18 years of age * able and willing to complete a questionnaire on their environmental/occupational exposures and smoking/alcohol history exclusion criteria: * at the discretion of the treating physician, patient will not be able to fulfill the requirements of the study.
impact of anesthesia type on outcome in patients with acute ischemic stroke (ais) undergoing endovascular treatment

Conditions: Acute Stroke

Summary: recent observational studies have found an association between general anaesthesia and increased post-operative mortality in acute ischemic stroke patients undergoing endovascular treatment. it is unknown whether there is a causal relationship in this observation. the investigators are performing a large randomised trial of general versus local anaesthesia to definitively answer the question of whether anaesthetic type alters perioperative outcome.


Eligibility criteria:
inclusion criteria: * patients with ais scheduled to receive emergency endovascular treatment, older than 18; the onset time is within 12 hours. exclusion criteria: * radiological ambiguity concerning infarction and vessel occlusion. * additional intracerebral hemorrhage. * posterior circulation infraction. * coma on admission (glasgow coma score less than 8). * nihss less than 10 or more than 35. * severe agitation or seizures on admission. * obvious loss of airway protective reflexes and/or vomiting on admission. * being intubated before treatment on admission. * known allergy to anesthetic or analgesic.

Keywords: ischemic stroke anesthesia endovascular procedures
gene polymorphism of il17 and il 23

Conditions: COVID-19 Respiratory Infection

Summary: rates are in such considerable amount among large population base. the pathogenesis of covid-19 implicates a potent inflammatory response, involving a complex group of mediators including interleukins. these pleiotropic cytokines are secreted at the region of inflammation and released into the circulation by a variety of different cell types, including macrophages, lymphocytes, endothelial cells, epithelial cells during sepsis and acute organ injuries. there has recently found a number of studies reporting that the cytokine storms take part in the course of covid-19

aim of the study 1. to evaluate if there is an association between the il-17, il-23 gene polymorphism in patients with covid 19 by real-time pcr 2. to measure the serum level of il17 by elisa in covid 19 patients by elisa. 3. to detect if there is an association between gene polymorphism of il17 and il23 and severity of a condition in patients with covid 19 study design: a cross-sectional study. the blood samples will be collected from patient records in covid19 isolation hospitals in sohag governorate and isolation department in sohag university hospitals.

Eligibility criteria:
inclusion criteria: * patients with covid19 positive pcr exclusion criteria: * patients with covid19 clinical criteria not confirmed by pcr
the effect of continuous midwifery-led care in birth management

Conditions: Labor Pain

Summary: caesarean section is an emergency procedure necessary to prevent harm or death to the mother or newborn. worldwide, caesarean section rates are steadily increasing. this increase not only has negative consequences on maternal and child health, but also leads to a reduction in essential resources and impedes access to health services worldwide. the international federation of gynaecology and obstetrics (figo) has called for help from government bodies, professional organisations, women's groups and other stakeholders to reduce unnecessary caesarean sections. according to a review of antenatal and intrapartum interventions to reduce caesarean section, promote vaginal birth and reduce fear of childbirth; the importance of support in the intrapartum period is prominent. the national institute for health and care excellence (nice) states that this support with a midwife who provides care and one-to-one support to the woman in labour reduces women's anxiety and increases their sense of trust.

vaginal delivery of low-risk pregnancies is best provided and guided by a midwife. it is seen that receiving support from a midwife in the birth of low-risk pregnancies does not increase the risks for the mother or newborn and has many economic and emotional advantages. the world health organisation recommends respectful care based on woman-centred care in the intapartum period for a positive birth experience. respectful maternity care has been recognised as a key strategy to improve the quality of maternity care. although there is no clear consensus on the definition of respectful maternity care, it is generally considered synonymous with intimate and woman-centred care. it is a care approach that emphasises the fundamental rights of women, newborns and families and increases adequate access to evidence-based care while recognising their needs and preferences. in this direction, midwives are expected to add respectful maternity care to their clinical skills in the management of the birth process. in the literature, it is seen that respectful and helpful interaction between women and health professionals during labour creates positive perceptions in women. in the study of liu et al. (2021), it is stated that midwife-led management of labour leads to the formation of positive perceptions in women. fear of labour, labour pain and duration of labour in midwife-led care on the behaviour of the students in the study.

Eligibility criteria:
inclusion criteria: * pregnant women with spontaneous pregnancy between 38-42 weeks of gestation * single fetus head presentation * first pregnancy * without any pregnancy-related risk status (such as preeclampsia, gestational diabetes) * who were admitted to the delivery room for normal labour will be included in the study. exclusion criteria: * women who cannot give birth normally * want to leave the labour force

Keywords: labour pain respectful motherhood care birth duration comfort of birth