Kornimate/medical-research-clean huggingface dataset:
eye muscle needle electromyogram (emu) study

Conditions: Strabismus

Summary: in some cases, strabismus, or squint, is treated with injections of botulinum toxin (btx) to temporarily relax the eye muscle responsible for causing the eye to be pulled to one side. due to the deep location of the muscles, electromyogram (emg) needle guidance is used to help ensure the toxin is delivered accurately. emg needle guidance involves listening to the emg signal from the tip of the delivery needle - when the needle is in the right place a sound akin to "rain on a tin roof" is heard and the btx can be injected. from previous research, clearly clinicians want to improve the technology of this procedure and increase the treatment efficacy and repeatability. after all, the current procedure is imprecise and subjective for what is a small target, with the eye muscles being around 2.5 mm to 4.7 mm in diameter. there may also be an increase in the likelihood of side effects such as droopy eyelids when the toxin spreads beyond the target muscle. there is a strong need for new knowledge to improve emg needle guidance in this context. it is hypothesised that the emg signal could be cleaned and mined for information in real time during the procedure, thus providing the clinician with better information to guide the positioning of the needle before injecting. this pilot study will deliver the knowledge essential to indicate the feasibility of doing this. if feasible, this study will inform a full study with the aim of benefitting patients by allowing new technology to be developed to improve the treatment of strabismus with btx.


Eligibility criteria:
inclusion criteria: i. adults undergoing planned, routine emg needle guided btx injection into either lateral or medial rectus muscle for the treatment of strabismus. ii. patients being treated by mr yagan. exclusion criteria: - patients with chronic progressive external ophthalmoplegia (cpeo) are excluded; a highly attenuated emg signal is expected.

Keywords: extraocular muscle electromyogram monopolar needle guidance botulinum toxin strabismus
photoacoustic imaging (pai) of suspicious breast cancers - a clinical feasibility study

Conditions: Breast Cancer

Summary: after locating the suspicious lesion/mass with standard of care mammography and/or ultrasound, a photoacoustic scan will be performed in the breast where the lesion is located. after the pa scan a biopsy will be performed, if clinically indicated (based on the mammogram and ultrasound only).


Eligibility criteria:
inclusion criteria: * patients must have a breast lesion/mass found at physical examination, mammography or ultrasound (us), that has not been surgically resected * patients may have any of the following characteristics: * taking hormones (e.g., contraceptives, hormone replacement therapy, post-cancer tamoxifen) * breast implants * previous breast biopsy * previous breast surgery * previous breast cancer * high risk of breast cancer (e.g., breast cancer susceptibility gene (brca) mutations, other gynecologic cancer) * ability to understand and the willingness to sign a written informed consent document exclusion criteria: * patients who have had primary surgical excision of the suspicious finding * pregnant or lactating women
icbt for children and adolescents with obsessive-compulsive disorder

Conditions: Psychotherapy Intervention Evaluation

Summary: internet-based psychotherapy for children and adolescents with obsessive-compulsive symptoms and an age of 7 to 17 years. sessions are verified with teleconferencing with an psychotherapist, children and their parents. the psychotherapy is supported by an app and a wristband to obtain psychophysiological data.


Eligibility criteria:
inclusion criteria: * children and adolescents (ages 7-17) with a primary dsm-5 obsessive-compulsive disorder and at least 1 primary caretaker * german-speaking (child \& caretakers) * family home equipped with broadband connection and appropriate computer, monitor, hd webcam, and speaker and smart phone exclusion criteria: * iq below 70 * a psychiatric comorbidity that makes participation clinically inappropriate (for example, primary anorexia nervosa), depression with suicidality that requires acute treatment, and psychosis

Keywords: cognitive-behavioral psychotherapy obsessive-compulsive disorder internet-based
renal and cardiac risk factors of aki after liver transplantation

Conditions: Acute Kidney Injury; Acute Renal Injury; Liver Transplant; Complications

Summary: background: liver transplantation (lt) is an extensive operation with various factors contributing to the development of acute kidney injury in the perioperative period. early diagnosis of aki can improve clinical outcomes in lt recipients. renal resistive index is measured in renal arteries and high resistive values are associated with more adverse cardiovascular events and renal failure progression. myocardial performance index reflects overall cardiac function rather than systolic or diastolic function alone. aim of the study: to investigate whether combined doppler renal resistive index and myocardial performance index could predict early postoperative acute kidney injury in living donor liver transplant recipients. study design: a prospective observational study that will be conducted at liver transplantation unit at mansoura university on 105 consecutive living donor liver transplant recipients. methods: renal resistive index (assessed by transabdominal ultrasound) and myocardial performance index (assessed by transthoracic echocardiography) will be measured just before operation, on termination of operation and then daily in the intensive care unit for 7 days. patients will be observed for development of acute kidney injury.

this study aims to investigate whether combined doppler renal resistive index (rri) assessed by transabdominal sonography and myocardial performance index (mpi) assessed by transthoracic echocardiography could predict early postoperative acute kidney injury in living donor liver transplant recipients. the primary outcome is the predictive value of renal resistive index and myocardial performance index for the onset of early post living donor liver transplant acute kidney injury. this prospective observational study will be conducted at liver transplantation unit at mansoura university from november 2022 till fulfillment of sample size after obtaining approval from institutional review board (irb). one hundred and five consecutive ldlt recipients will participate in this study after obtaining informed consents. they will be observed for the development of early postoperative acute kidney injury.

Eligibility criteria:
inclusion criteria: * patients undergoing right-lobe living-donor liver transplantation exclusion criteria: * preoperative renal impairment (gfr \< 60 ml/min/1.73 m2) * known renal artery stenosis * patient who underwent previous nephrectomy * ischemic heart disease (patient who takes anti-ischemic measures as prescribed by a consultant cardiologist) * patient with arrthymia or who develop persistent intraoperative arrythmia

Keywords: 2-d echocardiography two-dimensional echocardiography renal resistive index myocardial performance index diagnostie test accuracy sensitivity and specificity
use of a phosphodiesterase type 5 inhibitor to improve anabolic resistance in older adults

Conditions: Sarcopenia

Summary: this study will be the first demonstration of the utility and feasibility of phosphodiesterase type 5 inhibitor as an effective pharmacological therapy for improving anabolic resistant states.


Eligibility criteria:
inclusion criteria: * ages 60-75 yrs * recently prescribed 5mg of tadalafil daily for clinical purposes exclusion criteria: * history of diabetes * history of hypotension including orthostatic hypotension * history of malignancy or chemo/radiation therapy in the 6 months prior to enrollment * history of short gut syndrome, gastrointestinal bypass/reduction surgery (lap band, gastric sleeve, etc.) * subjects who cannot refrain from using protein or amino acid supplements for 7 days prior to visit 2 and 3. * alcohol consumption of ≥ 5 units/servings per day * concomitant use of * oral or injectable corticosteroids * testosterone, insulin like growth factor-1, or similar anabolic agent * riociguat (adempas) * nitroglycerin * isosorbide dinitrate (isordil) * isosorbide mononitrate (imdur, monoket) * doxazosin (cardura) * prazosin (minipress) * terazosin (hytrin) * any other disease or condition that would place the subject at increased risk of harm if they were to participate, at the discretion of the study physician
assessing the accuracy of the optowire deuxtm in a wire to wire comparison

Conditions: Coronary Artery Disease; Coronary Stenosis; Atherosclerosis; Atherosclerosis, Coronary; Angina, Stable; Angina, Unstable; NSTEMI - Non-ST Segment Elevation MI

Summary: the goal of the accuracy study is to assess the differences, if any, in ffr measurements made by the optowire deux ffr guidewire by comparison of simultaneous data of two different optowire deuxtm guidewires (group 1). in addition, the investigators will compare (group 2) the ffr measurements obtained from an optowire deux ffr guidewire and compare it to the ffr measurement by a verrata-tm guidewire to assess coronary stenosis in the routine clinical practice.

this is a single center, prospective, non-blinded clinical investigation enrolling consecutive patients with coronary lesion candidate for ffr assessment. the study aim to assess the differences, if any, in ffr measurements made by the optowire deux ffr guidewire by comparison of simultaneous data of two different optowire deuxtm guidewires (group 1, n=30). in addition, the investigators will compare (group 2, n=15) the ffr measurements obtained from an optowire deux ffr guidewire and compare it to the ffr measurement by a verrata-tm guidewire to assess coronary stenosis in the routine clinical practice. the clinical investigation will be conducted in the centre hospitalier de l'université de montréal (chum). no clinical follow-up is requested after the end of the procedure.

Eligibility criteria:
inclusion criteria: * single de novo coronary lesion or in-stent restenosis lesion with an operator assessed reference diameter ≥2.0 mm requiring ffr measurement based on the operator's clinical judgment exclusion criteria: * patients with st-segment-elevation myocardial infarction (stemi), culprit lesion of non-st-segment-elevation myocardial infarction (nstemi), new york heart association class iv heart failure, suspected or visible thrombus, dissection or excessive calcification or tortuosity in the target vessel, or a stenosis in a bypass graft will be excluded.
trottinettes urgences 2019-2020

Conditions: Traumatic Injury; Accidental Injury; Alcohol Drinking; Traffic Accident; Emergencies

Summary: the purpose of the study was to evaluate the risk, consequences and epidemiology of electric scooter accidents admitted to the emergency room at st. pierre university hospital. this prospective observational study aims to include any patient admitted to the adult emergency department of st.pierre university hospital brussels following an accident related to the use of an electric scooter in order to describe and understand the epidemiology, complications and treatment of injuries associated with this means of transport. it is intended to include all accidents occurring in the emergency room during the period from 01/06/2019 to 30/06/2020.

all patients over the age of 16 years with traumatic injuries due to an accident related to the use of an electric scooter were included in the study. upon admission to the emergency department, patients over 16 years of age who accepted were included in the study. the objectives of the study were firstly to describe the context and incidence of scooter accidents, and secondly to understand the epidemiology, complications and treatment of injuries associated with this means of transport and finally, to estimate the economic impact assessed by the number of days of post-traumatic work disability, the need for access to more specialised and therefore more expensive care (operating theatre interventions, scanner-type radiological examinations or hospitalisation in intensive care units). the data analyzed were based on : 1) the time and day of the accident, 2) the time of presentation at the hospital (same day or after the accident), 3) the mechanism of the accident, whether there were one or two people on the scooter, 4) the use or non-use of the protective helmet, 5) the influence of alcohol ; 6) the mode of arrival at the emergency room (type of ambulance or by one's own means); 7) the injury assessment, paraclinical examinations; 8) treatments; 9) hospitalization or not; 10) temporary work interruptions .

Eligibility criteria:
inclusion criteria: * all patients with traumatic lesion following electric sccoter accident * be able to agree to participate in the study exclusion criteria: * \< 16 years * unconscious * being unable to agree to participate in the study

Keywords: electronic scooter helmet traumatic injury alcohol drinking traffic accident emergencies
periodonitis and alzheimer's disease

Conditions: Alzheimer Disease; Periodontitis

Summary: the main objective of this study is to assess whether periodontal disease is more prevalent in adult patients diagnosed with alzheimer's disease compared to adult patients without alzheimer's disease. the secondary objective is to describe and characterize the microbiological and biochemical profile of adult patients diagnosed with alzheimer's disease and compare with adult patients without alzheimer's disease.

to assess the possible association of periodontal disease with alzheimer's disease, i propose to carry out an observational, paired and cross-sectional study. it will be evaluated whether adult patients diagnosed with alzheimer's disease have a higher prevalence of periodontal disease when compared to adult patients without alzheimer's disease. as well, it will be evaluated whether adult patients with different stages of alzheimer's disease have different stages of severity of periodontitis. the study sample will be obtained from the associação portuguesa de alzheimer, in the lisbon region, consisting of adult patients diagnosed with alzheimer's disease (test group). the control group sample will consist of patients who attend consultations at the faculty of dental medicine, university of lisbon, matched for age, gender and other confounding factors, such as tobacco and systemic diseases (diabetes).

Eligibility criteria:
inclusion criteria: will be included in the study all individuals who attend the portuguese alzheimer's association, diagnosed with alzheimer's disease, who: 1. have voluntarily given their consent to participate; 2. due to cognitive or functional disability, they were unable to give free and informed consent, but they had this consent given by their representative 3. individuals who have participated in the cognitive assessment (only for the test group) exclusion criteria: * a) refused oral observation.

Keywords: alzheimer disease periodontitis
outcome of 68ga-pentixafor pet/ct versus adrenal vein sampling in primary aldosteronism

Conditions: Primary Aldosteronism

Summary: to compare the 68ga-pentixafor pet/ct and adrenal vein sampling on the long-term outcomes of primary aldosteronism (pa) patients with adrenal nodule (≥1cm)

this is a randomized study involving patients with primary aldosteronism (pa) patients with adrenal nodule (≥1cm) who completed avs or 68ga-pentixafor pet/ct.we will enroll 320 pa patients with adrenal nodule (≥1cm) .all paticipants will be randomized into 68ga-pentixafor pet/ct group(intervention group) and avs group(control group) to compare the long-term outcomes of patients with pa.

Eligibility criteria:
inclusion criteria: (1)getting the written informed consent (2)arr ≥20 (pg/ml)/ (μiu/ml) or arr ≥ 30(ng/dl)/(ng/ml/hr) plus at least one positive pa confirmatory test (cct, ssit). (3)patients who are willing to undergo surgery. (4)patients with hypertension aged 18-70 years. (5)ct or mri scan of the adrenal glands with nodule (≥1cm). exclusion criteria 1. combined with autonomous cortisol secretion, cortisol after 1mg dexamethasone suppression test (dst) ≥50 nmol/l. 2. pa patients who meet the by-passing avs criteria \[i.e., younger than 35 years old, spontaneous hypokalemia, adrenal ct indicated unilateral low-density adenoma (≥1cm), plasma aldosterone \>300pg/ml\] 3. suspicion of familial hyperaldosteronism or liddle syndrome. \[i.e., age \<20 years, hypertension and hypokalemia, or with family history\] 4. suspicion of pheochromocytoma or adrenal carcinoma. 5. patients with actively malignant tumor. 6. patients who have adrenalectomy history or with adrenocortical insufficiency. 7. long-term use of glucocorticoids. 8. pregnant or lactating women; with alcohol or drug abuse and mental disorders. 9. congestive heart failure with new york heart association (nyha) functional classification iii or iv; history of serious cardiovascular or cerebrovascular disease (angina, myocardial infarction or stroke) in the past 3 months; severe anemia (hb\ 3 times the upper limit of normal, or estimated glomerular filtration rate (egfr) \< 30 ml/min/1.73 m2); systemic inflammatory response syndrome (sirs); uncontrolled diabetes (fbg≥13.3 mmol/l); obesity (bmi≥35 kg/m²) or underweight (bmi≤18 kg/m²); untreated aneurysm; other comorbidity potentially interfering with treatment

Keywords: primary aldosteronism; adrenal venous sampling 68ga-pentixafor pet/ct outcome multicenter randomized
post-market study of the epik knee system

Conditions: Osteoarthritis; Post Traumatic Degenerative Disease

Summary: the purpose of this study is to determine the short-term (2 yr) and midterm (5 yr) cumulative revision rates of the epik™ uni-compartmental knee system.

medial uni-compartmental knee replacement (uka) has been used for over 40 years to treat osteoarthritis (oa) of the knee. it is becoming more widely accepted as a treatment for early stage oa of the knee in order to preserve bony and ligamentous structures. the majority of the subjects who have received this knee are older (over 65 yrs) however, it is being used increasingly more frequently in younger individuals who have uni-compartmental knee disease so that bone may be spared in case the need arises in the future for a total knee arthroplasty. the study will take place at two sites within the united states and be managed by the clinical affairs department at djo surgical in austin, tx. the study will include only subjects who meet the indications for use criteria for the epik™ uni-compartmental knee system and who are candidates for uka. investigators will enroll up to 60 subjects at each of 2 sites within the united states, for a total of 100 subjects maximum.

Eligibility criteria:
inclusion criteria: * meet the indications for use of the epik uni-compartmental knee system * must be a primary surgery * have a primary diagnosis of oa in the medial knee compartment * have active and passive flexion \> 90º * have a fixed flexion contracture \< 10º * have an intact acl and pcl * be a primary, unilateral surgery * have bmi ≤ 35.00 * must not have infection (or history of infection within last 3 months), chronic or acute, local or systemic * must not be pregnant * be willing and able to sign the informed consent * be willing to follow study procedures, including all follow up visits * be over 18 years of age (≥ 18) and 60 years or younger (≤ 60) at time of consent exclusion criteria: * prior total or uni-knee arthroplasty (must be a primary surgery) * patello-femoral joint symptoms * bilateral surgical procedures * bmi \> 35.00 * muscular, neurological or vascular deficiencies which compromise the affected extremity * insufficient bone quality which may affect the stability of the implant * infection (or history of infection within last 3 months), chronic or acute, local or systemic * is younger than 18 years of age (\ 60) years of age * mental conditions that may interfere with the subject's ability to give an informed consent or willingness to fulfill the study requirements * high levels of physical activity (ex. competitive sports, heavy physical labor) * documented (active) alcohol or drug addictions * loss of ligamentous structures * prisoner * metals sensitivity * subject is pregnant

Keywords: medial knee replacement
exploring functional paralysis with advanced magnetic resonance modalities

Conditions: Functional Neurological Symptom Disorder; Paralysis; Conversion Disorder with Weakness/Paralysis

Summary: in functional neurological disorder (fnd), neurological symptoms are present, such as paralysis, weakness and disturbed sensation of limbs, although clinically no abnormalities can be found. it is a poorly understood disorder with uncertain diagnosis, treatment and prognosis. in this study, the subtype functional paralysis is investigated with advanced neuroimaging techniques that go beyond standard clinical examinations. in previous research on fnd, healthy volunteers have generally been used as a control group. however, since people with functional paralysis have similar symptoms to people with spinal cord injuries (sci), it is intended to compare the three groups to find similarities and differences. with the proposed methods, the goal is to gain a detailed understanding of fnd regarding nerve cell metabolism, diffusion pathways and neuronal networks involved in cognitive processes such as motor inhibition (reaction or no reaction depending on situation). neurophysiological data, clinical assessments and questionnaires are carried out in addition to magnetic resonance imaging (mri). the aim is to enrol 75 participants in this study, i.e. 25 people with fnd, 25 people with sci and 25 healthy control subjects. the overall goal of the study is to find markers for fnd for use in future studies to improve diagnosis and individualise therapy recommendation for both people with sci and people with fnd. therefore, this study is a relevant step to understand fnd and to diagnose this specific disease using objective mri based diagnostic tools.


Eligibility criteria:
inclusion criteria: * age between 18-65 exclusion criteria: * contraindication for magnetic resonance examinations (e.g. cardiac pacemaker, pregnancy, etc.) * history of mental or neurological illness (addiction, central nervous system tumour and severe craniocerebral trauma) * unable to hold a pen due to paralysis