Kornimate/medical-research-clean huggingface dataset:
dynamic area telethermometry (dat) as an imaging modality in patients with cancer

Conditions: Malignant Tumors; Subcutaneous Tumors; Lymph Node Tumors

Summary: the purpose of this study is to evaluate whether this new method of taking pictures called dynamic area telethermometry (dat) might be a good way of looking at patients with cancer that is relatively close to the surface of the body.

* the dat system resembles a video camera which picks up changes in body temperature which may reflect disease-related changes in blood flow to some areas, particularly those involved with tumors. * patients with known tumor sites amendable to dat evaluation will be imaged at the time of staging and at later time points. thermal profiles will be compared to those of normal adjacent tissues and correlated with the images of the tumors on conventional images.

Eligibility criteria:
inclusion criteria: * histologically confirmed malignancy * primary or secondary tumor location amendable to dat scanning: subcutaneous tissues * older than 15 years of age * able to withhold movement for 20 seconds, hold breath for 20 seconds for chest wall lesions and clinically stable acutely exclusion criteria: * uncontrolled motion * tumors not verified or measurable by standard imaging

Keywords: dat imaging modality
ckd-391 pharmacokinetic study phase i

Conditions: Healthy

Summary: a randomized, open-label, 2-way crossover study to compare the pharmacokinetics and safety ckd-391 to coadministration atorvastatin and ezetimibe in health volunteers.

to compare the ckd-391 (experimental product) to the dose atorvastatin calcium and ezetimibe combination in health male subjects is the purpose of this trial. following are evaluated in this trial; characteristics and safety/tolerability of ckd-391.

Eligibility criteria:
inclusion criteria: * bwt \>=50kg, bmi 18.5\~25 * signed the informed consent form prior to the study participation exclusion criteria: * - clinically significant disease * subject has signs of symptoms of acute disease within 28 days of starting administration of investigational drug * clinically significant allergic disease * impossible to taking the institutional standard meal * previously donate whole blood within 60 days or component blood within 20 days * previously participated in other trial within 90 days * continued to be taking caffeine (caffeine \> 5 cup/day), drinking(alcohol \> 30 g/day) or cannot stop drinking or severe heavy smoker(cigarette \> 10 cigarettes per day)during clinical trials * an impossible one who participates in clinical trial by investigator's decision including laboratory test result

Keywords: dyslipidemia ckd-391 atorvastatin ezetimibe
magnesium sulfate versus nifedipine for the acute tocolysis of preterm labor: a prospective, randomized trial

Conditions: Obstetric Labor, Premature

Summary: to compare intravenous magnesium sulfate to oral nifedipine for acute tocolysis of preterm labor


Eligibility criteria:
inclusion criteria::- uterine contractions and cervical change or ruptured membranes in a preterm gestation exclusion criteria:- placental abruption, fetal distress, placenta previa, maternal medical contraindication to tocolysis
comparison of hands-on versus online learning about ocular ultrasound

Conditions: Emergencies

Summary: in patients who visit an emergency room with ocular symptoms, point-of-care ultrasound can quickly identify several emergency diseases. while training of eye ultrasound skills is useful for emergency physicians, hands-on education is risky in pandemic situation such as coronavirus disease 19 (covid19). as a solution to this, non-face-to-face education via online has been on the rise. the investigators hypothesized that even an online education is enough to perform basic eye ultrasound by emergency physician.

since the eye is an superficial organ, it has excellent access to ultrasound. also, the eye has a liquid-filled structure (vitreous body), it is suitable for obtaining some important findings with bedside ultrasound. in patients who visit an emergency room with ocular symptoms, point-of-care ultrasound can quickly identify several emergency diseases. while training of eye ultrasound skills is useful for emergency physicians, hands-on education is risky in pandemic situation such as covid19. as a solution to this, non-face-to-face education via online has been on the rise. the investigators hypothesized that even an online education is enough to perform basic eye ultrasound by emergency physician.

Eligibility criteria:
inclusion criteria for doctors: * those who have received basic ultrasound education but have not received ocular ultrasound education * residents and interns working in the emergency room * those who voluntarily agree to participate in the research through the recruitment announcement inclusion criteria for standard patients: * adults over 18 years of age without eye-related symptoms * those who do not have unusual findings in the eye when scanning by ultrasound * those who voluntarily agree to participate in the research through the recruitment announcement exclusion criteria for standard patients: * those with a history of ophthalmic diseases * those who have a history of ophthalmic surgery such as lens implantation
follow-up study 16-20 years after primary vaccination against hepatitis b of newborns from hbeag+ & hbsag+ mothers

Conditions: Hepatitis B

Summary: the purpose of this study is to evaluate the persistence of anti-hepatitis b surface antigen (anti-hbs) antibodies 16, 17, 18, 19 and 20 years after administration of the first dose of the study vaccine. the protocol posting has been updated in order to comply with the fda amendment act, sep 2007.

the primary study was designed to evaluate the immunogenicity and protective efficacy of hepatitis b vaccine in newborns of hbeag+ and hbsag+ mothers in comparison with a historical control group. the present study is carried out to evaluate the anti-hbs persistence 16-20 years after the first vaccine dose and to further investigate the prevalence and incidence of other hepatitis b markers and the clinical significance of these at all time points from year 16-20. no additional subjects will be recruited during this long-term follow-up study and no vaccine will be administered.

Eligibility criteria:
inclusion criteria: * subjects who had received at least one dose of the study vaccine in the primary study (103860/064) * written informed consent obtained from each subject before each blood sampling visit

Keywords: long-term follow-up hepatitis b antibody persistence
induction therapy with pd-1 antibody combined with platinum-based doublet chemotherapy for locally-advanced non-small cell lung cancer

Conditions: Locally Advanced; Non-small Cell Lung Cancer

Summary: for unresectable locally-advanced non-small cell lung cancer, chemoradiotherpay plus immunotherapy is recommended by pacific trial. however, it is unclear whether surgery can provide survival benefit for patients with tumors initially unresectable transformed into resectable ones after chemoimmunotherapy. this trial aims to investigate the efficacy and safety of the therapeutic regimen of chemoimmunotherapy plus surgery.


Eligibility criteria:
inclusion criteria: 1. the patient shall sign the informed consent form. 2. aged 18 ≥ years. 3. histological or cytological diagnosis of nsclc by needle biopsy, and stage iiib-iiic confirmed by imageological examinations (ct, pet-ct or ebus). 4. eastern cooperative oncology group (ecog) performance-status score of 0 or 1. 5. life expectancy is at least 12 weeks. 6. at least 1 measurable lesion according to recist 1.1. 7. patients with good function of other main organs (liver, kidney, blood system, etc.) 8. patients with normal lung function can tolerate surgery; 9. without systematic metastasis (including m1a, m1b and m1c); 10. fertile female patients must voluntarily use effective contraceptives not less than 120 days after chemotherapy or the last dose of serplulimab (whichever is later) during the study period, and urine or serum pregnancy test results within 7 days prior to enrollment are negative. 11. unsterilized male patients must voluntarily use effective contraception during the study period not less than 120 days after chemotherapy or the last dose of serplulimab (whichever is later). exclusion criteria: 1. participants who have received any systemic anti-cancer treatment for thymic epithelial tumor, including surgical treatment, local radiotherapy, cytotoxic drug treatment, targeted drug treatment and experimental treatment; 2. participants with any unstable systemic disease (including active infection, uncontrolled hypertension), unstable angina pectoris, angina pectoris starting in the last three months, congestive heart failure (\>= nyha) grade ii), myocardial infarction (6 months before admission), severe arrhythmia requiring drug treatment, liver, kidney or metabolic diseases; 3. with activate or suspectable autoimmune disease, or autoimmune paracancer syndrome requiring systemic treatment; 4. participants who are allergic to the test drug or any auxiliary materials; 5. participants with interstitial lung disease currently; 6. participants with active hepatitis b, hepatitis c or hiv; 7. pregnant or lactating women; 8. participants suffering from nervous system diseases or mental diseases that cannot cooperate; 9. participated in another therapeutic clinical study; 10. other factors that researchers think it is not suitable for enrollment.
the aim study: assessing the impact of margin reduction

Conditions: Prostate Cancer

Summary: this study will observe patients who receive external beam radiation for prostate cancer. these patients will be localized and tracked (targeted) with the calypso 4d localization system. these patients will have a uniform treatment plan with reduced ptvs (prostate treatment volume) and will be assessed at multiple time points for quality of life and side effects related to radiation therapy.

epic surveys and adverse events recorded and categorized using the ctcae v3.0 will be collected and summary statistics performed. the patient's individual tracking graphs will be evaluated for motion type and frequency.

Eligibility criteria:
inclusion criteria: 1. patients who are planning to receive external beam radiation of prostate 2. patients who are to be implanted with beacon transponders in the prostate 3. 18 years of age or older. 4. histologically confirmed diagnosis of prostate cancer. 5. ability to comply with study visit schedule. 6. signed informed consent form. exclusion criteria: 1. any patients who have received other investigational therapy within the last 60 days are excluded. 2. individuals that have previously been implanted with permanent beacon transponders are excluded. 3. patients that have any prosthetic implants in the pelvic region that contain metal or conductive materials (e.g., an artificial hip). 4. any other medical or other condition that would, at the discretion of the investigator, preclude the individual from participation in a clinical study.
gait training for persons with stroke

Conditions: Stroke; Middle Cerebral Artery Infarction

Summary: the objective of this study is to investigate the effects of an automatic gait trainer (lokomat) handled by physical therapists compared with categorized gait training by physical therapists in ambulatory stroke patients. gait speed, gait distance and gait symmetry are used to evaluate study effects. hypotheses: 1) the lokomat improves stroke patients gait speed, distance and symmetry more than categorized gait training.


Eligibility criteria:
inclusion criteria: 1. first time stroke 2. middle cerebral artery infarction 3. less than three month from stroke onset 4. able to walk with or without a stick at gait speed less than 0.5 m/s 5. participants are able to cope with the lokomat exclusion criteria: 1. co-morbidity which impedes study participations 2. language deficits which makes it impossible to understand oral or written study instructions 3. more than 190 cm tall and 135 kg in weight 4. pregnancy 5. no gait function prior stroke 6. skin sore or eruption on lower extremity or trunk, differences in lower extremity length of more than 2 cm or contracture of lower extremity which impedes gait training in the lokomat -

Keywords: ambulatory stroke patients gait training lokomat physical therapy
the 3 years vs 1 year dapt after xinsorb brs implantation

Conditions: Cardiovascular Diseases

Summary: the aim of the sparta trial is to clarify the impact of extending dapt beyond 1 year after xinsorb brs implantation by investigating the balance of risk and benefit in a broad population of treated patients.


Eligibility criteria:
inclusion criteria: 1. subjects with xinsorb brs implantation, then treated with dapt for 12 months 2. written informed consent from the subjects 3. qualified candidates for coronary bypass surgery 4. lesions with reference vessel diameter 2.75 to 3.5 mm exclusion criteria: 1. age ≤ 18 years 2. cardiogenetic shock 3. chronic heart failure with a left ventricular ejection fraction ≤ 30% 4. oral anticoagulation therapy 5. known allergy or intolerance to the study medications 6. malignancies and other comorbid conditions with a life expectancy less than 5 years 7. subjects treated with both brs and des during the index procedure 8. pregnant wowen 9. planned staged pci 10. contemporaneous enrollment in a different clinical trial 11. any revascularization within 1 year 12. planned surgery necessitating discontinuation of antiplatelet therapy within 36 months after enrollment 13. unprotected left main artery 14. lesions located at the ostium of the main coronary artery 15. bifurcation lesions (medina 1,1,1) planning to be treated with two stents strategy
kinetics of b cell response in infants menjugate vaccination

Conditions: Prevention of Meningococcal Infection

Summary: kinetics of b cell response in infants menjugate vaccination


Eligibility criteria:
inclusion criteria: * healthy infants exclusion criteria: * previously ascertained or suspected disease caused by n. meningitidis * previous household contact with an individual with a positive culture of n. meningitidis serogroup c

Keywords: prevention of meningococcal meningitis vaccines, conjugate immunology infant antibody persistence
a study with asp2151 in subjects with recurrent episodes of genital herpes

Conditions: Herpes Genitalis

Summary: a study of asp2151 in subjects with recurrent outbreaks of genital herpes.


Eligibility criteria:
inclusion criteria: * subject has a history of genital hsv documented by laboratory testing at screening * subject has experienced 4 or more episodes of genital herpes during the past 12 months exclusion criteria: * subject is immunocompromised

Keywords: asp2151 herpes genitalis sexually transmitted disease herpes simplex virus genital infection treatment outcome genital herpes
acupuncture - a treatment for children with headache

Conditions: Headache

Summary: acupuncture as a treatment for headache in children

a randomised controlled study in the effect of acupuncture as a treatment for headache in children. the children are randomised for training or for training and acupuncture.

Eligibility criteria:
inclusion criteria: * diagnosed by pediatrician- * age-9-17 years * min. headache 8 times within the last month exclusion criteria: * mentally illness * fear of needles

Keywords: acupuncture training children effect
lqt and smartphone/smartwatch

Conditions: Long QT Syndrome

Summary: congenital long qt syndrome (lqts) is a rare genetic disorder characterized by prolongation of the corrected qt interval (qtc) on the electrocardiogram. lqts is associated with a risk of syncope or sudden death from ventricular arrhythmia. the increase in the duration of the corrected qt interval and / or changes in the morphology of the t wave on the electrocardiogram are markers of an increased risk of sudden death and syncope. recently, a personal portable 6-lead device (di, dii, diii, avf, avl and avr) connected to the patient's smartphone has entered the market (kardia mobile 6l, alivecor, mountain view, california, usa). the apple watch series 6 (apple, cupertino, ca, usa) can also record an ecg. if the device is designed to record a single lead (di), several works have shown that it is possible to record 9 leads (di, dii, diii, v1, v2, v3, v4, v5 and v6) by moving simply the device (spaccarotella cas et al. jama cardiology 2020). these devices were originally designed to screen for atrial fibrillation, but they produce accurate 6- and 9-lead ecgs and could potentially allow ambulatory ecg monitoring of patients with lqts.


Eligibility criteria:
inclusion criteria: patient with diagnosis of lqts based on the following criteria: * corrected qt (qtc) interval according to bazett method ≥ 480 ms, at several times in the absence of a secondary cause * and / or class 4 or 5 mutation in a gene involved in long qt syndrome * and / or syncope (s) and qtc\> 460ms in the absence of other cause * all ages * no opposition from the patient exclusion criteria: none -
therapeutic drug monitoring of adalimumab in psoriasis patients

Conditions: Psoriasis

Summary: the main goal of this study is to determine optimal cut-off values of adalimumab trough levels corresponding to good clinical response. determination of these values is necessary to compose a therapeutic algorithm, in which the dosing schedule can be adjusted according to serum trough levels of adalimumab and aaa (anti-adalimumab antibodies). a secondary objective of this study is to further detect and quantify aaa and to correlate them with adalimumab and clinical response in a real life setting cohort of psoriatic patients.

in a multicenter cross-sectional study, 73 adult patients treated with adalimumab (40 mg) every other week for at least 24 weeks are assessed for psoriasis disease severity through measurement of the psoriasis area and severity index (pasi) before adalimumab treatment start, and prior to sampling. patients who interrupted their treatment schedule during the 24 weeks prior to blood sampling are excluded. samples of patients who were treated with adalimumab for any other inflammatory disease and later developed psoriasis are also excluded. percentage of pasi improvement compared to baseline (∆pasi) represents clinical response. patients are classified as nonresponders (∆pasi\<50), moderate responders (∆pasi 50-75) or good responders (∆pasi 75-100).serum is collected for adalimumab trough level and anti-drug antibody determination (sanquin, the netherlands). by receiver-operator characteristics (roc) analysis, a cut-off value of adalimumab trough level can be determined to distinguish insufficient from adequate responders.

Eligibility criteria:
inclusion criteria: * minimum age 18 years old * chronic plaque psoriasis * adalimumab (40mg) subcutaneously every other week * at least 24 weeks of adalimumab treatment exclusion criteria: * interruption of treatment schedule during 24 weeks prior to sampling * adalimumab for other inflammatory disease and later developed psoriasis

Keywords: adalimumab biologicals immunogenicity
gut permeability and bariatric-metabolic surgery

Conditions: NASH - Nonalcoholic Steatohepatitis; Bariatric Surgery Candidate; Intestinal Permeability

Summary: increased intestinal permeability and dysbiosis have been causally associated with nafld and nash progression. however, to date, there are no systematic studies, on the effect of bariatric-metabolic surgery on intestinal permeability and dysbiosis in the context of nafld development.

morbid obesity is associated with non-alcoholic fatty liver disease (nafld) in 80-90% of patients, and non-alcoholic steatohepatitis (nash) occurs in up to 60% of patients. if left untreated, the disease can progress to liver fibrosis, cirrhosis, or hepatocellular carcinoma. weight loss of \>10% of body weight is the most effective treatment for nafld, and bariatric metabolic surgery plays an effective role in achieving long-term weight loss. about 80% of patients achieve improvement or reversal of nafld after bariatric-metabolic surgery. however, clinical and histological progression of liver disease may occur in about 20% of patients, despite weight the loss. increased intestinal permeability and dysbiosis have been causally associated with nafld and nash progression. however, to date, there are no systematic studies, on intestinal permeability and dysbiosis after bariatric-metabolic surgery. research questions * to investigate the changes in intestinal permeability after bariatric-metabolic surgery. * to investigate the differences in intestinal permeability at the time of surgery and 1 year after surgery between patients with liver fibrosis grades f≤1 and f≥2 (low-grade fibrosis vs advanced fibrosis). * to investigate differences between patients with and without liver fibrosis progression using parameters for metabolic endotoxemia, intestinal permeability, and dysbiosis.

Eligibility criteria:
inclusion criteria: * patients with morbid obesity undergoing bariatric metabolic surgery according to the ifso criteria, * willingness to attend all follow-up visits * written consent exclusion criteria: * other liver disease than nafld * presence of ibd, acute pancreatitis, amyotrophic lateral sclerosis, pregnancy

Keywords: liver fibrosis nafld one anastomosis gastric bypass roux-en-y gastric bypass gut-liver axis
investigation of the effect of proprioceptive neuromuscular fasilitation tecniques in scapular dyskinesis

Conditions: Scapular Dyskinesis

Summary: scapular dyskinesis is defined as the loss of strength around the scapular muscle, tightness of the pectoralis minor and disruption of scapular movements. scapular patterns of proprioceptive neuromuscular fasilition (pnf) techniques are often preferred in the rehabilitation of scapular dyskinesis. the main principals of pnf applications are defined as the autogenous inhibition, reciprocal inhibition, stress relaxation and gate control theory.the aim of this study was to investigate the effect of scapular pnf patterns on muscular strength and pectoralis minor tightness among individuals with unilateral scapular dyskinesis.

in order to standardize the measurements while evaluating individuals, the evaluation order will be as follows; the evaluation of minor pectoralis shortness, scapular dyskinesia by video analysis, scapular side shift test and then muscle strength evaluation will be done. the evaluation will be repeated before and 6 weeks after treatment and 12 weeks after treatment. proprioceptive neuromuscular facilitation application: anterior elevation / posterior depression will be performed in the form of repetitive contractions using anterior depression / posterior elevation patterns. there will be 10 repetitions, with a 2-minute rest break between each technique. the treatment will be continued twice a week for a total of 6 weeks. perceived effort scale, which is graded between 0-10, will be used to determine the level of perceived resistance to individuals before each treatment. in order to ensure standardization, the perceived effort level will be set to 5-6 (moderate).

Eligibility criteria:
inclusion criteria: * to be in the age range of 18-30, * being a sedentary, * having type 1 or type 2 scapular dyskinesia. exclusion criteria: * has shoulder pain, * acute orthopedic injuries in the last 3 weeks, involving the upper extremity, * having had upper extremity surgery.

Keywords: scapular dyskinesis