Kornimate/medical-research-clean huggingface dataset:
trial comparing best supportive care to aloe vera gel

Conditions: Radiation Dermatitis

Summary: radiation therapy (rt) has been a component of breast cancer treatment for almost 100 years. although initially used for the treatment of chest wall recurrences after mastectomy and for advanced inoperable disease, rt has evolved into a critical component of early therapy for women with an intact breast following lumpectomy and for mastectomized women who are at high risk for local failure. currently breast cancer patients need a multidisciplinary management including surgery, chemotherapy and radiotherapy, radiotherapy has a significant role in loco regional control of the disease. it is estimated that 87% of these women will develop some degree of radiation-induced dermatitis, varying from mild to brisk erythema or even moist desquamation. topical agents, such as corticosteroid creams and other products including aquaphor (beirsdorf inc, wilton, ct), and trolamine (biafine; genmedix ltd, france), are commonly prescribed at the onset of radiation dermatitis or, in some institutions, at the beginning of radiotherapy. the aim of this randomized phase iii study was to assess the effectiveness of aloe vera cream for the prevention of acute radiation-induced dermatitis of grade 2 or higher during postoperative radiotherapy for breast cancer, compared to best supportive care. the secondary objectives were to assess pain, treatment interruption as a result of skin reactions, and the quantity of life during the treatment.


Eligibility criteria:
inclusion criteria: * the women had to be 18 to 75 years of age with a nonmetastatic breast adenocarcinoma treated by either lumpectomy or mastectomy with or without adjuvant postoperative chemotherapy or hormonal treatment, and referred to the department of radiotherapy for postoperative radiotherapy. concomitant chemotherapy was allowed. exclusion criteria: * women with bilateral cancer, patients who were allergic to either of the two agents, and pregnant women were excluded. * no rash, ulceration, bleeding, or unhealed scar was allowed in the treatment area. * patients were excluded for: prior radiation therapy (rt), mastectomy, skin involvement by tumor, history of, or current connective tissue disorder, medical contraindication (allergy or sensitivity) to aloevera or planned bsc, and inability to comply with treatment regime. the use of bolus was prohibited.

Keywords: radiation dermatitis best supportive care aloe vera gel phase iii study was to assess the effectiveness of aloe vera and vitamin e.
study of interferon gamma-1b by injection for the treatment of patients with cystic fibrosis

Conditions: Cystic Fibrosis

Summary: the purpose of this research study is to evaluate the safety, tolerability, and efficacy of interferon gamma-1b (ifn-gamma 1b) when administered by subcutaneous injection over a period of 4 weeks to patients with mild-to-moderate cystic fibrosis. additionally, preliminary assessments on the effects of ifn-gamma 1b on lung function and other indicators of health will be made.


Eligibility criteria:
* at least 6 years of age * diagnosis of cystic fibrosis (against certain criteria) * able to perform pulmonary (lung) function tests and participate in induced sputum procedures * pulmonary function values must meet certain minimal requirements * must have acceptable laboratory test results * cannot be on certain medications during and immediately prior to study * cannot have a history of unstable or deteriorating cardiac or neurologic disease

Keywords: cystic fibrosis pulmonary impairment
laser light cues for gait freezing in parkinson's disease

Conditions: Parkinson's Disease

Summary: the purpose of this study is to gather data to see if the laser cane and/or u-step walker with laser accessory is more effective in aiding with gait freezing than a regular cane/u-step walker in patients who have idiopathic parkinson's disease.

freezing of gait is a significant clinical problem in parkinson's disease (pd). it interferes with daily functioning and quality of life and often results in falls that potentially can inflict serious injury. in recent years, much more attention has been focused on the clinical characteristics of gait freezing, the severity of falls that can result, and the use of visual cues as a possible treatment in order to understand the implications of episodic freezing. few clinical studies have been done to confirm the clinical observations to date. the laser cane is a device that has been used and prescribed in movement disorder centers as the only form of treatment for freezing of gait. although it has been shown to be effective in many cases, there is no published data to support what has been observed in the clinic. the proposed study seeks to clarify unanswered questions regarding the laser cane and its efficacy in aiding with episodic gait freezing and falls.

Eligibility criteria:
inclusion criteria: * subjects or a designated proxy have given informed consent * subject has been diagnosed with idiopathic parkinson's disease * subject is ambulatory. if a wheelchair is used part-time, it must be used for less than 50% of the time * positive assessment for questionnaire used to identify freezing of gait in pd patients at subject's best "on" exclusion criteria: * presence of atypical features suggestive of msa, psp, ataxia, unexplained or prominent pyramidal signs, and/or autonomic dysfunction * subjects who are non-ambulatory more than 50% of the time * subjects who have had a history of syncope in the 6 months prior to screening * subjects with moderate or advanced dementia

Keywords: parkinson's disease laser cane freezing of gait visual cues
a study to assess prevalence of a specific protein overexpression in adult participants with non-small cell lung cancer

Conditions: Non Small Cell Lung Cancer

Summary: non-small cell lung cancer (nsclc) is the most common type of lung cancer, accounting for 80%-85% of lung cancers cases of which 60% are non-squamous (nsq). this study will evaluate the prevalence of mesenchymal epithelial transition (met) overexpression (oe) in adult participants with advanced or metastatic nsq nsclc. archived tissue biopsies will be tested for met oe and data from approximately 500 participants will be collected. no participants will be enrolled in this study. participants' charts will be reviewed. no drug will be administered as a part of this study. the duration of the study will be approximately 15 months. there is no additional burden for participants in this trial.


Eligibility criteria:
inclusion criteria: * previously consented and/or prospective collection of consent for research use of banked biological materials and clinical data. * confirmed advanced and/or metastatic non-squamous (nsq) non-small cell lung cancer (nsclc). * has formalin-fixed paraffin-embedded (ffpe) tissue collected since 2019. exclusion criteria: * specimens collected before 2019. * insufficient specimen tissue for testing. * insufficient specimen quality (e.g., not 4-5 µm in thickness) which precludes testing. * adenosquamous and sarcomatous histologies of nsclc.

Keywords: non small cell lung cancer telisotuzumab vedotin abbv-399 cancer
study of the relationship between glycogen storage disease type ia and inflammatory bowel disease

Conditions: Inflammatory Bowel Disease; Glycogen Storage Disease Type Ia

Summary: the purpose of this research study is to understand the relationship between inflammatory bowel disease (ibd) and glycogen storage disease (gsd)type ia. gsd type ib has been established to have an association with ibd with clinical and histologic features that mirror those of crohn disease. development of the disease seems to be related to the defect of neutrophil function in individuals with gsd type ib and subsequent colonic inflammation. in the last decade, it has become a standard for patients with gsd type ib and gastrointestinal symptoms to be evaluated for ibd. patients with gsd type ia were not recognized to have similar gastrointestinal symptoms until recently. the prevalence of ibd is greater in patients with gsd type ia versus the general population.

the purpose of this research study is to understand the relationship between ibd and gsd type ia. the investigators will be attempting to develop a blood test which will be aimed at the participants diagnosis of ibd. as a participant in this research study, a blood sample will be collected during your admission to the university of florida. this will not affect the length of stay of your scheduled visit. there will be no scheduled clinic follow-up.

Eligibility criteria:
inclusion criteria: * anyone with glycogen storage disease type ia exclusion criteria: * anyone where the amount of blood needed to complete the prometheus test exceeds 3ml/kg.
randomized controlled study of the traditional percutaneous coronary intervention and intervention using optical coherence tomography of incomplete stent adhesion and extent of the formation of neointima by resolute zotarolimus-eluting stent insertion

Conditions: Coronary Artery Disease; Stable Angina; Unstable Angina

Summary: optical coherence tomography (oct) after the stent procedure to improve the adhesion and expansion, or incomplete uncovered struts attached to the main track. oct in clinical areas by improving the parameters of the best stent will be useful. however, for better results for optical coherence tomography in percutaneous interventions have little useful data on the role. randomized controlled study of the traditional percutaneous coronary intervention and intervention using optical coherence tomography.


Eligibility criteria:
inclusion criteria: * single lesion in a single vessel * reference vessel diameter 2.5 - 3.5 mm * lesion length ≤ 34 mm and ≤ 34 mm stent length * stable angina requiring revascularization, patients with unstable angina * the patient has no difficulty to enforce the follow-up angiography * patient is ≥ 20 years old exclusion criteria: * lesions with graft vessel, thrombosis, restenosis, and bifurcation requiring 2 stents * reference vessel diameter \ 4.0mm * contraindication to anti-platelet agents * treated with any des within 3 months at other vessel * creatinine level ≥ 2.0 mg/dl or esrd * severe hepatic dysfunction (3 times normal reference values) * patients with lvef \< 30% * life expectancy 1 year * lesions with cto or left main * target vessel of st-elevation mi * lesions requiring overlapped stenting or more than 2 des in each vessel * heavy calcified lesions (definite calcified lesions on angiogram) * far distal or tortuous lesions having difficulties in oct evaluation or follow-up oct * pregnant women or women with potential childbearing

Keywords: resolute zotarolumus-eluting stent optical coherence tomography
physical exercise as an adjunct treatment for depression

Conditions: Major Depressive Disorder

Summary: 35 participants diagnosed with major depressive disorder were randomized in 3 intervention groups: (1) aerobic exercise (ae) ; (2) placebo (stretching) exercise (st); and (3) no intervention (control group; ni). the intervention length was 10 consecutive days. in groups 1 (aerobic exercise) and 2 (sham exercise), participants exercised for 30 minutes each day. depressive symptoms were assessed the day before the beginning of intervention and the day after the end of intervention for participants of both groups.

in the aerobic exercise (ae) group, the intervention consisted of 30 minutes of daily brisk walking or jogging. this was done individually and supervised. participants who missed \> 2 training sessions were considered as non-completers. exercise intensity had to be maintained within 65%-75% of age-predicted maximal heart rate, as commonly prescribed in studies using aerobic exercise to alleviate depression. heart rate monitoring devices were used. participants in the stretching (st) group also performed a daily 30 minutes exercise program but this was "sham" exercise, consisting of stretching exercises. several muscle groups (thighs, calves, gluteal, shoulders, back) were stretched for 60 seconds, with equivalent resting intervals between stretching series. these activities were also individual and supervised. as was the case for the ae intervention, participants who missed \> 2 training sessions were considered as non-completers. participants in the control (ni) group received no intervention other than prescribed medication. all participants started antidepressants within less than 2 weeks before study entry.

Eligibility criteria:
inclusion criteria: * diagnosis of major depressive disorder (mdd) * antidepressant drug therapy initiated for less than 2 weeks * score of 29 or more on the beck depression inventory exclusion criteria: * medical contraindication for exercise practice * inability to understand written french * beta-blocking drugs or another forms of antidepressant therapy (sleep deprivation, electroconvulsive therapy)
a prospective observational study of artificial intelligence morphometric evaluation of vertebral fractures

Conditions: Vertebral Fracture; Osteoporosis

Summary: the study will be conducted as a monocentric observational prospective study design wants to evaluate the prevalence of vertebral fractures in the cohort of patients that perform a chest-abdomen ct for medical indication other than osteometabolic pathologies.

this study aimed to evaluate the prevalence of vertebral fractures in a cohort of patients that perform a chest-abdomen ct for medical indication other than osteometabolic pathologies.it is estimated that 250 patients will be enrolled (patients will be enrolled in retrospective and prospective way between 01/03/2025 and 28/02/2026. the presence of one or more vertebral fractures will be evaluated through the radiological medical assessment with automatic 3d reconstruction of the thoracic and lumbar spine and by application of the ai software nanoxaihealthvcf nano-x imaging ltd on abdomen-chest ct studies. clinical, anthropometric, and anamnestic data will be collected from patients undergoing ct assessments. these data will be collected on the day of the radiological examination. there will be only one evaluation at the time of the ct scan. only in case of fracture detection, via radiological medical assessment and/or via ai software, the patient will be subsequently evaluated in the endocrinology unit as for standard of care.

Eligibility criteria:
inclusion criteria: 1. male subjects 2. age ≥ 50 years 3. clinical and medical history data available at abdomen-chest ct evaluation 4. signature of informed consent to the study exclusion criteria: 1. hospitalized patients 2. patients known to have osteo-metabolic diseases. 3. with primary and/or acquired immunodeficiency states, and/or severe impairment of general clinical condition (e.g. metastatic neoplasms; immunosuppressive therapies; worsening/reacute/compensated chronic diseases; moderate-severe renal failure) 4. patients unable to understand and sign the informed consent.
prospective evaluation of spleen injury treatments in languedoc roussillon

Conditions: Trauma

Summary: descriptive, prospective, multicenter evaluation of spleen injury treatment in the languedoc roussilon region according to trauma severity, morbi-mortality and length of hospitalization.


Eligibility criteria:
inclusion criteria: * hospitalized for abdominal trauma * diagnosis of splenic contusion confirmed by scanner or during surgery for hemodynamically unstable cases * patient has signed a consent form * patient is a beneficiary of or affiliated with a social security program exclusion criteria: * refuses to participate * pregnant or breastfeeding * patient under guardianship

Keywords: spleen
comparison of clinical performance and subjective preference of three contact lenses

Conditions: Myopia

Summary: the purpose of this study is to evaluate the clinical performance and subject's preference out of three lre (limbal ring enhancing) lens types: etafilcon a (johnson\&johnson), methafilcon a (interozzo), and methafilcon a (coopervision).

this will be a subject-masked, bilateral, randomized, crossover dispensing study to compare clinical performance and subjective preference out of three lens types. sixty subjects will be assigned into three groups and each group will wear the test and control lenses as matched pairs for one week in random order. lenses will be worn on a daily wear, daily disposable schedule.

Eligibility criteria:
inclusion criteria: * age of 18 years and above and has full legal capacity as a volunteer understand the rights as a research subject and willing and able sign a statement of informed consent * existing soft contact lens wearers or previous experience of contact lens wear * being able to wear the study lenses for at least eight hours a day * at least 6/9 visual acuity in each eye with the study lenses * astigmatism less than 1.50 d (diopter) in both eyes * agreed to follow the protocol and not to participate in other clinical research for the duration of this study exclusion criteria: * have an ocular disorder which would normally contraindicate contact lens wear * have a systemic disorder or any infectious diseases which would normally contraindicate contact lens wear * have previously had any ocular surgery such as corneal refractive surgery * have less than 6/9 visual acuity in each eye with the study lenses * are currently using any topical medication such as eye drops or ointment * have any corneal distortion resulting from previous rigid lens wear or have keratoconus * are currently pregnant or lactating * no previous contact lens wear
physical activity choices everyday- a pilot study

Conditions: Obesity

Summary: this study aims to test two strategies for weight loss. participants will be randomly assigned to one of the two 4-week weight loss programs: (1) a behavioral weight loss program that involves recording weekly weight, physical activity, and caloric intake plus daily exercises in which information about a healthy lifestyle is reviewed or (2) a behavioral weight loss program that involves recording weekly weight, physical activity, and caloric intake plus daily exercises in which descriptions of positive future events are reviewed. throughout the study, participants will complete assessments that examine the effects of the interventions on delay discounting, physical activity, weight, and other important health and psychosocial outcomes.


Eligibility criteria:
inclusion criteria: * age between 18-70 * body mass index between 30-50 * english speaking * have a smartphone that can be used for study activities exclusion criteria: * report being unable to walk 2 blocks without stopping * are currently participating in weight loss treatment, have a history of bariatric surgery, or lost ≥5% in the past 6-months * are pregnant or plan to become pregnant within 2 months * report a heart condition, chest pain during periods of rest or activity, or loss of consciousness on the physical activity readiness questionnaire * report a medical condition that could jeopardize their safety in a weight control program with diet and exercise guidelines * history of or current traumatic brain injury, dementia or alzheimer's disease; a history of multiple sclerosis, or other neurological disorders * report conditions that, in the judgment of the pi, would render them unlikely to follow the protocol (e.g., relocation, dementia, unable to read and write in english) * have no internet access or unwilling to use personal smartphone for study.
post-marketing safety study in japan of shock and anaphylaxis after severe acute respiratory syndrome coronavirus 2 (sars-cov-2) mrna-1273 covid-19 vaccine in persons in at high risk of severe covid-19

Conditions: SARS-CoV-2

Summary: the goal of this study is to confirm the onset status of hypersensitivity reactions including shock and anaphylaxis observed after vaccination with this drug in persons with underlying diseases who are considered to have a high risk of severe exacerbation of covid-19 and explore risk factors.

data collected from the jdmc claims database between may 2021 to november 2021.

Eligibility criteria:
inclusion criteria: * participants registered to receive the mrna-1273 vaccine in the pep up vaccination history database * participants who have a history of vaccination with the mrna-1273 vaccine in the pep-up vaccination history database and the observation start date is at least 6 months prior to vaccination with the mrna-1273 vaccine and have underlying diseases. data period for confirmation of presence/absence of underlying disease is may 2021 to november 2021. exclusion criteria: * underlying diseases that were determined undetectable by the pre-screening of jmdc * participants who did not consent to the questionnaire.

Keywords: mrna-1273 mrna-1273 vaccine sars-cov-2 sars-cov-2 vaccine coronavirus virus diseases messenger rna covid-19 covid-19 vaccine moderna
comparisonof extended myoectomy and myoectomy by morrow in patients with hypertrophic obstructive cardiomyopathy (hocm)

Conditions: Hypertrophic Obstructive Cardiomyopathy

Summary: the purpose of this study is to determine whether the application of the extended myoectomy in patients with obstruction of the left ventricular output more efficient than standard myoectomy by morrow.

many years myoectomy for morrow was the gold standard in the treatment of obstructive hypertrophic cardiomyopathy. currently more retrospective data in the literature about the good results the extended septal myectomy. use of extended myomectomy eliminates mitral insufficiency due to sam syndrome. the question remains whether it is possible at hypertrophic cardiomyopathy basal part and mediated mitral insufficiency use only myoectomy by morrow is achieved regression sam syndrome and release output of the left ventricle. planned to create two equal groups of 30 people that will use two methods of surgical treatment of obstructive hypertrophic cardiomyopathy. the study will be terminated in the event of complete av block more than 2% and unsatisfactory results of a myoectomy requiring perform mitral valve replacement in more than 15% of the patients studied. the study assumed crossover: in case of failure elimination sam syndrome and mediated mitral insufficiency myoectomy by morrow for patients will perform extended myoectomy in the case of a good result in patients are moved to the second group. planned studies the long-term and immediate results of operations: * quantitative determination of enzymes of myocardial injury: creatine phosphokinase mb and troponin i. * determination of atrial natriuretic peptide (anp) and brain natriuretic peptide (vnp). * mri with contrast heart to assess remodeling of the heart chambers and heart weight measurements. * tee evaluation function and mitral valve gradient at the output of the left ventricle.

Eligibility criteria:
inclusion criteria: * able to sign informed consent and release of medical information forms * age ≥ 18 years * obstructive hypertrophic cardiomyopathy * mediated mitral insufficiency by sam syndrome * ii-iv (nyha), * average systolic pressure gradient greater than 50 mm hg. art. at rest; * basal or medium ventricular obstruction exclusion criteria: * related defect of the aortic valve; * organic mitral valve disease (dysplasia, rheumatic fever, infective endocarditis); * surgically significant coronary artery lesions; * patients requiring implantation of a cardioverter-defibrillator

Keywords: hypertrophic cardiomyopathy mitral valve sam syndrome