obesity and osa in pregnancy

Conditions: Obesity; Obesity, Maternal; Obstructive Sleep Apnea; Blood Pressure

Summary: the purposes of this project are 1) to compare the impact of maternal obesity versus excessive gestational weight gain on obstructive sleep apnea (osa) in obese and non-obese women; 2) to investigate the mechanism(s) by which obesity and osa increase cardiovascular risk during pregnancy; and 3) to identify biomarker(s) for obesity-related osa in pregnant women.

aim 1: to test the hypothesis that maternal obesity increases osa risk but to a greater extent in obese women with excessive gestational weight gain vs. obese women with normal weight gain vs. non-obese women with excessive weight gain. study team will enroll early pregnant (≤12 weeks of gestation) obese (pre-pregnancy body mass index ≥30 kg/m2) and non-obese (body mass index 18.5-24.9 kg/m2) women and follow participants throughout gestation. in-home sleep testing will be carried out during all phases of pregnancy: early pregnancy (4-12 weeks gestation), late pregnancy (30-34 weeks of gestation) and postpartum (6-10 weeks after delivery). investigator will compare ahi (primary endpoint), the development or worsening of osa, and pregnancy outcomes in obese and non-obese women with and without weight gain above the institute of medicine (iom) recommended levels. various body composition areas, (e.g., neck, waist, or hips) that may be associated with risk for sleep apnea will also be measured. aim 2: to test the hypothesis that obesity is associated with sympathetic activation, while osa magnifies this abnormality during pregnancy. study team will use the state-of-the-art technique of microneurography to measure resting sympathetic activity (primary endpoint) and sympathetic neural responses to physiological stimulations (e.g., mental stress, exercise and upright posture) during early (\<12 weeks) and late (30-34 weeks) pregnancy, and postpartum (6-10 weeks post) in obese women with and without osa and non-obese women without osa. aim 3: to test the hypothesis that corin content is greater in obese than nonobese women during pregnancy, and it is the greatest in obese pregnant women with osa. venous blood samples will be taken in women enrolled in aim 2 study for measurements of serum corin content (primary endpoint) and pregnancy-specific angiogenic factors such as soluble fms-like tyrosine kinase 1, placental growth factor, and soluble endoglin. the relationships between maternal corin content, pregnancy-specific angiogenic factors, sympathetic activity, and bp will be explored.

Eligibility criteria:
inclusion criteria: * both obese and non-obese (normal weight) early pregnant women aged ≥18 years old will be permitted to participate in this project. * no restriction with respect to race and socioeconomic status * women with a prior history of complicated pregnancy (i.e., gestational hypertension, preeclampsia, hellp syndrome, gestational diabetes, preterm birth, intrauterine growth restriction, etc.) will be allowed to participate. * obese women with previously diagnosed osa will be allowed to participate if they are not currently on any recognized treatments such as continuous positive airway pressure (cpap), oral appliances or nasal expiratory positive airway pressure. * those who have had surgery for osa in the past will be excluded. * women taking low-dose aspirin will be allowed to participate in this project. exclusion criteria: * current multiple pregnancy; * known major fetal chromosomal or anatomical abnormalities; * recurrent miscarriage (three or more); * chronic essential hypertension (systolic bp \>140 mmhg and/or diastolic bp \>90 mmhg); * any evidence of cardiovascular and pulmonary diseases by history or by physical examination; * kidney disease (serum creatinine \>1.5 mg/dl); * coagulation disorders; * diabetes mellitus (fasting glucose ≥126 mg/dl or 2-hour oral glucose tolerance test glucose level ≥200 mg/dl) or other systemic illness; * any evidence of neurological disease; * psychiatric disease or psychological disorders; * history of drug or alcohol abuse within the last 2 years; and * given the effects of exercise training on sympathetic neural control, endurance-trained athletes will be excluded. as this project focuses on sleep apnea in pregnancy, women with other significant sleep disorders such as restless legs syndrome by rest leg syndrome diagnostic index and insomnia by the insomnia severity index or pittsburgh sleep quality index will be excluded; in addition, women who report taking a sleeping aid \>1 time per month will be excluded.

Keywords: obesity pregnancy sleep apnea blood pressure