Kornimate/medical-research-clean huggingface dataset:
a study of keluo xin capsule compare to placebo in terms of efficacy and safety in patients with diabetic retinopathy

Conditions: Moderately Severe to Severe NPDR

Summary: this is a study aiming to assess the efficacy and safety of keluo xin capsule in patients with moderately severe to severe nonproliferative diabetic retinopathy (npdr). two-thirds of participates will receive keluo xin capsules while other one third will receive placebo.

this study composes two parts. the first is a 24-week period during which subjects receive designed treatment regimen; after that, subjects will be informed again for the next 24-week regimen (extention phase) and can choose whether or not to participate in the treatment (with the same regimen in the first period) voluntarily.

Eligibility criteria:
inclusion criteria: * 18 years to 70 years; * patients diagnosed with type 2 diabetes mellitus; * patients diagnosed with nonproliferative diabetic retinopathy; * patients diagnosed with traditional chinese medicine syndrome(tcm) differentiation of both qi and yin deficiency with blood stasis; * hba1c≤8.0%; exclusion criteria: * study eye been received panretinal photocoagulation; * study eye with neovascular elsewhere or neovascular of the disc, or neovascularization of iris; * prior panretinal photocoagulation in the study eye within 6 months; * uncontrolled blood pressure; * subjects who develop chronic diarrhoea; * any history of acute diabetic complications; * any history of allergy to components of keluo xin capsule; * pregnant or breast-feeding women.
local anaesthesia used during fast-track colonic surgery: evaluation of bupivacaine and levobupivacaine in practice

Conditions: Colonic Diseases; Post-operative Pain; Local Anesthesia

Summary: the standard treatment for post operative pain is now bupivacaine + sufentanil. the use of this combination during fast-track colonic surgery leads frequently to post-operative nausea and vomiting and limited mobilisation possibilities. therefore the department anaesthesiology wants to evaluate the use of a different local anaesthetic: levobupivacaine combined with morphine on demand. the expectation is that the use of levobupivacaine leads to less side effects.


Eligibility criteria:
inclusion criteria: * patients who undergo fast-track colonic surgery and with post operative epidural pain treatment exclusion criteria: * patients who are admitted to an other ward * patients with a spinal catheter

Keywords: post-operative pain treatment fast-track colonic surgery patients surgery
trial on the effect of e-cigarette advertising on cigarette perceptions in adolescents

Conditions: Attentional Bias; Smoking Cues; Positive Perceptions About Cigarette Smoking; Social Norms; Smoking Susceptibility

Summary: this research aims to investigate how exposure to advertising for electronic nicotine delivery systems (commonly called e-cigarettes) may lead to combustible smoking initiation in adolescents.

\[3/14/2020\]: study recruitment temporarily halted due to the covid-19 pandemic

Eligibility criteria:
inclusion criteria: - exclusion criteria: * exclusion criteria will include inadequate english proficiency, and diagnosis of a learning or vision disorder.

Keywords: positive smoking expectancies e-cigarette advertising adolescents
person-centred support for women after treatment for gynaecological cancer

Conditions: Malignant Female Reproductive System Neoplasm; Follow-up; Supportive Care; Psychosocial Circumstances; Survivorship

Summary: women treated for gynaecological cancer perceive many difficulties in life on the personal, social, and physical levels. today they are offered a 3 to 5 year follow-up programme at the hospital where the main purpose is to improve survival. however, the women are very nervous before follow-up visits and although they feel safe about them, they express that their needs of psychosocial care and self-management support are not fulfilled. the proposed study will test a person-centred intervention tailored the women's needs in a randomised controlled trial. the intervention will be based on the method guided self determination (gsd), which has proved able to realize empowerment in practice in relationships between patients and healthcare professionals. gsd involves systematic use of condition-adjusted worksheets ('reflection sheets'), and advanced professional communication. using reflection sheets filled out by each woman as the starting point for communication, problem solving will be tailored her personal needs. we expect that the intervention has the potential to support the women in better managing specific complications and difficulties related to concerns about recovery, body perception, fertility and establishment of intimate relations with their partner, all aspects important for the women's quality of life in the follow-up period after cancer diagnosis and treatment. the study will be the first to test gsd in cancer patients.


Eligibility criteria:
inclusion criteria: * women only surgically treated for cervix, ovarian (including borderline tumors), endometrial or vulva cancer, who attend follow up at the gynaecological department at the university hospital rigshospitalet in copenhagen. * the women should read, write and understand the danish language. exclusion criteria: * known recurrence. * participation in the preliminary pilotstudy. * health related problems both physical or psychological, that prevent participation. for example cognitive impairment, or patients with psychiatric diseases that is estimated to require nurses with competences within the psychiatric speciality.

Keywords: self-management intervention psychosocial care autonomy-supportive gynaecological cancer survivors guided self-determination
correlative cohort study on the clinical features and prognosis of drug-induced liver injury

Conditions: Drug-induced Liver Injury

Summary: this was a retrospective study of a clinical observational cohort. the patients were admitted and definitely diagnosed by liver biopsy as drug-induced liver injury from september 2014 to september 2019, in the second department of liver disease, beijing ditan hospital affiliated to capital medical university were enrolled, and these patients also met the rucam score and were clinically diagnosed as dili. baseline clinical data and follow-up biochemical data at 3, 6, and 12 months were collected. spss software was used to analyze the characteristics of clinical data and the dynamic changes of biochemical indicators. logistic regression was used to analyze the risk factors associated with the chronicity of dili. bivariate logistic regression model and roc curve were used to obtain the clinical indicators for combined diagnosis of chronicity of dili patients. to investigate the clinical features and prognostic factors of drug-induced liver injury.

this was a retrospective study of a clinical observational cohort. the patients were admitted and definitely diagnosed by liver biopsy as drug-induced liver injury from september 2014 to september 2019, in the second department of liver disease, beijing ditan hospital affiliated to capital medical university were enrolled, and these patients also met the rucam score and were clinically diagnosed as dili. baseline clinical data and follow-up biochemical data at 3, 6, and 12 months were collected. spss software was used to analyze the characteristics of clinical data and the dynamic changes of biochemical indicators. logistic regression was used to analyze the risk factors associated with the chronicity of dili. bivariate logistic regression model and roc curve were used to obtain the clinical indicators for combined diagnosis of chronicity of dili patients. to investigate the clinical features and prognostic factors of drug-induced liver injury.

Eligibility criteria:
inclusion criteria: * have a clear history of taking drugs (chinese herbal medicine and dietary supplements, nsaids, cardio-cerebrovascular drugs, anti-interference drugs, anti-tuberculosis drugs, hormone drugs and others); * all patients were examined by liver biopsy patients with clear diagnosis of drug-induced liver injury and clinical diagnosis of dili who meet the rucam score. exclusion criteria: * combined with various liver diseases, such as viral hepatitis (hepatitis a, b, c, d, e), alcoholic hepatitis, autoimmune hepatitis, metabolic hepatitis, non-alcoholic fatty liver disease; * combining other viral infections that may lose liver function, such as epstein-barr virus (ebv), cytomegalovirus (cmv), and human immunodeficiency virus (hiv); * mental illness; * evidence of liver tumors (liver cancer or alpha-fetoprotein\> 100 ng / ml).

Keywords: drug-induced liver injury chronic regression analysis roc curve joint diagnosis
new indices for prediction of human fatigue during training based on non-invasive methods

Conditions: Muscle Fatigue

Summary: sometimes, during strenuous aerobic activity, activity ceases only when the discomfort that follows lack of oxygen would be intolerable. reaching this fatigue condition can cause organ damage, muscular damage and / or in different tissues of the body. in this study, investigators aim at developing new indexes, based on hemodynamics measurements from the peripheral micro - circulation system, for the benefit of early detection of fatigue during accelerated physical activity.

14 healthy volunteers, 7 males and 7 females, aged 18-30 will participate in this study.the study includes 2 stages: in the first stage, aerobic capacity of the subjects will be measured by measuring maximum oxygen consumption (vo2max test). this phase will be conducted to determine physical measurements that could indicate different stages in muscle fatigue (anaerobic threshold, maximum oxygen consumption, heart rate and breathing indices). in the second phase, the subjects will perform the same physical effort protocol that carried out at the first stage. non- invasive measurements of leg muscles activity during aerobic exercise and at rest (before and after activity), will be carried out using a wireless emg. additionally, hemodynamic measurements of oxygen levels in the skin and skin perfusion monitoring before and after strenuous activity will be performed using two optic sensors.

Eligibility criteria:
inclusion criteria: * aged 18-30 years. * healthy civilian volunteers. * without known medical illness or medication use that might endanger the participants. exclusion criteria: * the existence or suspicion of existing cardiac or respiratory disease. * any metabolic disorder. * any muscles or skeleton condition. * any neurological condition. * the physician decision.
cryodevitalization for the treatment of early stage lung cancer, crystal trial

Conditions: Stage I Lung Cancer; Stage II Lung Cancer

Summary: this clinical trial studies side effects and best treatment time of cryodevitalization in treating patients with early stage (stage i or stage ii) lung cancer. cryodevitalization is a type of cryosurgery that uses a flexible probe (cryoprobe) to kill tumor cells by freezing them. it is delivered at the time of standard diagnostic robotic bronchoscopy. using cryodevitalization may be safe, tolerable and/or effective in treating patients with early stage lung cancer.

primary objective: i. to identify the maximum tolerated dose (mtd) for cryodevitalization cycle duration. outline: this is a dose-escalation study. patients undergo 3 freeze-thaw cycles of cryodevitalization over 30 seconds or 3, 5, or 7 minutes each during standard of care robotic bronchoscopy with biopsy on study. patients then undergo standard of care surgical resection on study. patients also undergo a chest radiography (x-ray) on study as well as computed tomography (ct) and tissue sample collection throughout the study. after completion of study treatment, patients are followed up at 3 and 7 days and are then followed as clinically required per standard of care for 24 months.

Eligibility criteria:
inclusion criteria: * patients with a single pulmonary nodule with a size less than or equal to three centimeters (average long and short axis) confirmed as malignant intraprocedurally (rapid on-site evaluation with pathology assessment showing lung cancer or oligometastatic disease) without evidence of mediastinal involvement who require nodule biopsy prior to proceeding with surgical resection * nodules must be located in the outer 2/3 of the periphery of the lung, greater than 10 mm from the pleura and from large blood vessels or mediastinal structures to avoid injury to other visceral organs * patients deemed to have a surgical resection treatment option based on preoperative staging computed tomographic (ct), postoperative predicted forced expiratory volume in 1 second (fev1) \> 40% and evaluation of medical comorbidities after discussion at multidisciplinary tumor board * age \> 18 years old exclusion criteria: * target nodule is within the international association for the study of lung cancer (iaslc) "central zone" (including bronchial tree, major vessels, heart, esophagus, spinal cord and phrenic \& laryngeal nerves), or are \< 10 mm from the pleura * patients with an expected survival less than 6 months * patients with endobronchial lesions, concerning for malignancy, visualized during the initial bronchoscopic evaluation of the airways * patients with medically uncorrectable coagulopathy: abnormal platelet count \ 1.5 * patients with known pulmonary hypertension (pasp \[pulmonary artery systolic pressure\] \> 50mmhg) * patients who are currently prescribed anticoagulants, clopidogrel, or other platelet aggregation inhibitors * patients with medical comorbidities deemed high-risk for surgical resection * pregnant women * inability to provide informed consent
motion capture analysis of sacroiliac joint motion after manipulation

Conditions: Sacroiliac Joint Pain

Summary: the purpose of this study is to examine the effects of manipulation on sacroiliac joint motion using a polhemus motion capture system.

the sacroiliac (si) joint is a diarthrodial joint with the contradictory biomechanical function of transmitting compressive loads from the lumbar spine to the lower extremity while maintaining a nutating motion in the pelvis. recent studies identify the sacroiliac (si) joints as a significant source of pain in patients with chronic low back pain, contributing up to 27%. recent studies have demonstrated that historical and physical examination findings and radiological imaging alone are insufficient to diagnose si joint pain. the purpose of this study is to examine the effects of manipulation on sacroiliac joint motion using a polhemus motion capture system. the absolute angular deviation of sacroiliac joint motion will be assessed during the normal gait cycle with the polhemus liberty motion capture system. six sensors will be attached to specific anatomical landmarks of the pelvis which recorded motion characteristics while walking on a treadmill at 5 mph. the subjects then receive a hvla manipulation to the si joint and were retested at the same treadmill speed. the motion capture system tracks objects at a speed of 240 updates per second on all sensors simultaneously. the latency of data sampling is less than 4ms; 240 x 60 sec x 8 sensors totaling 115,200 data points per minute. the system generates and tracks electromagnetic fields (emf), computes position and orientation of sensors in an x, y, and z coordinate system while interfacing with a computer. the emf source contains electromagnetic coils that emit a magnetic field. the source is the system's reference frame for sensor measurements. the sensor contains electromagnetic coils (accelerometers) that detect the position and orientation of the magnetic fields emitted by the emf source.

Eligibility criteria:
inclusion criteria: * ages between 20 and 40 * ability to maintain normal balance * willingness to undergo hvla manipulation to the si joints * normal blood pressure exclusion criteria: * any visual or vestibular condition or systemic illness that would affect balance * any recent surgery, unstable joints of the lower extremity, recent hip and knee joint replacements or fitted hip or knee pins, bolts and/or plates * currently have any infection, acute inflammation, recent wounds, injury, tumors or other malignancy * currently taking any medications; prescription or herbal muscle stimulants, relaxants, etc. * a history of acute disc herniation, discopathy or spondylolysis * a history of acute thrombosis, serious cardiovascular disease, diabetes, have irregular heartbeats(arrhythmia) or wear a pacemaker * any implanted device or prosthesis type of device * any spinal manipulation within 48 hours * ages under 20 and over 40 * estimated bmi greater than 30

Keywords: manipulation manual therapy sacroiliac joint effects on manipulation on sacroiliac joint
rapid renal sympathetic denervation for resistant hypertension

Conditions: Hypertension, Resistant to Conventional Therapy

Summary: the covidien oneshot™ ablation system use is to deliver low-level radio frequency (rf) energy through the wall of the renal artery to denervate the human kidney.

unique to the oneshot™ ablation system is the ability to deliver the desired helical treatment pattern for optimal renal denervation (rdn) with a single balloon based-treatment, eliminating user variance inherent in the currently available point-by-point approach. in addition, technological improvements have been incorporated. the oneshot™ rf generator has a touchscreen, user friendly interface; catheter advancement is made safer with the use of a guidewire; two radiopaque markers on the catheter enable more precise device positioning; and the irrigated catheter tip reduces the risk of overheating and clot formation during rf delivery. by offering a more reliable single treatment approach, coupled with enhanced ease-of use and reduced procedure times, this technology has the potential to significantly expand clinical adoption of catheter-based renal sympathetic denervation.

Eligibility criteria:
inclusion criteria: 1. systolic blood pressure ≥ 160 mmhg despite treatment with a regimen of 3 or more anti-hypertensive medications that includes a diuretic and that has been stable for 2 weeks prior to screening. 2. age 18-85 years. 3. able to provide informed consent and comply with follow-up visits. exclusion criteria: 1. diameter of left or right renal artery less than 4 mm or greater than 7mm. 2. length of target segment of left or right renal artery less than 20mm. 3. other renal arterial abnormalities including severe renal artery stenosis, previous renal stenting or angioplasty. 4. end-stage renal disease requiring dialysis or renal transplant. 5. estimated glomerular filtration rate \< 45 ml/min per 1.73 m2. 6. type 1 diabetes mellitus. 7. myocardial infarction, unstable angina, or cerebrovascular events within 6 months prior to screening. 8. severe valvular heart disease for which reduction of blood pressure would be considered hazardous. 9. bleeding disorder or refusing blood transfusions. 10. pregnancy or breast feeding. 11. peripheral vascular disease precluding catheter insertion. 12. any serious medical condition, which in the opinion of the investigator, may adversely affect the safety or effectiveness of the participant or the study. 13. current enrollment in another investigational drug or device study.

Keywords: hypertension kidney diseases kidney failure, chronic vascular diseases cardiovascular diseases urologic diseases renal insufficiency, chronic renal insufficiency
high intensity interval training in chronic stroke

Conditions: Stroke

Summary: the objective of this study was to compare the effectiveness of high intensity interval training (hit) and traditional aerobic training for persons with stroke.

participants were randomized to either hit or traditional aerobic training; each 25 minutes, 3 times per week for 4 weeks. outcomes were measured before and after training by a blinded rater.

Eligibility criteria:
inclusion criteria: * 1) age 35-90 years * 2) unilateral stroke experienced \>6 months prior to enrollment * 3) able to walk 10m overground with assistive devices as needed and no physical assistance * 4) able to walk 3 minutes on the treadmill at \>.13m/s (0.3mph) with no aerobic exercise contraindications * 5) stable cardiovascular condition (american heart association class b, allowing for aerobic capacity \<6 metabolic equivalents) * 6) discharged from formal rehabilitation exclusion criteria: * 1) significant resting ecg abnormalities * 2) evidence of significant arrhythmia or myocardial ischemia on treadmill ecg stress test * 3) hospitalization for cardiac or pulmonary disease within 3 months * 4) pacemaker or implanted defibrillator * 5) lower extremity claudication * 6) unable to communicate with investigators or correctly answer consent comprehension questions * 7) severe lower extremity spasticity (ashworth \>2) * 8) lower extremity weight bearing pain \>4/10 on visual analogue scale for the transcranial magnetic stimulation substudy, additional exclusions will also be applied. these include large cerebral infarcts or other structural defects with the potential to increase seizure risk, uncontrolled seizures, metal implants and previous craniotomy.

Keywords: stroke rehabilitation exercise intensity gait
cardiovascular health and risk modification in family health teams

Conditions: Cardiovascular Risk Factors; Hypertension; Hyperlipidemia; Diabetes

Summary: cardiovascular diseases remain the main cause of mortality in canada. while effective interventions are available for reducing the risk of cardiovascular disease,there continue to be gaps between the potential reduction in risk that could be achieved by effectively managing these risk factors and levels of risk factor control currently in clinical practice. this study will evaluate the ability of a different model of risk factor care using other health providers assisting family doctors, along with information aids for patients and health professionals,to achieve better levels of cardiovascular risk factor control in adults.


Eligibility criteria:
inclusion criteria: * adults 50 to 80 years of age * having attending a family medicine clinic for more than one year exclusion criteria: * not able to participate for one year * not able to read english * requires house calls * nursing home resident * cognitive impairment * current chest pain or symptoms of active coronary heart disease

Keywords: chronic disease management decision aids cardiovascular risk factors
pregnancy, nitrate, endothelial function and tissue oxygen saturation

Conditions: Pregnancy

Summary: adequate macro and microvascular endothelial function during pregnancy is essential for the normal placental development and growing fetus. beetroot juice (bj) promotes improvement ins this parameters in no-pregnant individuals, however the beneficial effect did not avaliated in pregnant. the present study evaluated effects of bj on macro and microvascular endothelial function in pregnant. twelve pregnant were submitted to bj and nitrate-depleted juice (pla) interventions. brachial flow-mediated dilation (fmd) and muscle oxygenation were measured 120 min after interventions. urinary nitrate, nitrite were measured at baseline and 120 min after interventions.


Eligibility criteria:
inclusion criteria: * gestation between 20 and 35 weeks; * over 18 years exclusion criteria: * diabetes mellitus and gestational diabetes; * hypertensive syndromes; * hiv positive; * liver or kidney disease; * beetroot allergy; * use of antioxidants and medicament that alter endothelial function; * use of antibiotics up to 2 weeks before the visits and using.

Keywords: dietary nitrate nitrate flow-mediated dilation tissue oxygen saturation