Kornimate/medical-research-clean huggingface dataset:
the effects of technological oral health management

Conditions: Oral Health; Malnutrition; Dysphagia; Sarcopenia

Summary: the goal of interventional study is to for the elderly who have poor chewing and eating ability after installing removable dentures through the intervention of oral mastication training and texture and diet education, the effects on oral health, eating ability, nutrition, and physical function changes are confirmed in elderly individuals residing in chiayi county who are 65 years of age or older, capable of self-care, conscious, and able to communicate in mandarin and taiwanese. the main question it aims to answer is: •are there significant benefits to oral health, eating ability, nutrition, and physical function through the intervention of oral mastication training and texture and diet education? researchers will compare changes in oral health, eating ability, nutrition, and physical functioning results to see if oral mastication training is effective. participants will: * experimental group: oral mastication training and texture and diet education. * control group: only texture and diet education. * cases were tracked in month 1 and will be tracked again in month 6.

expected results： 1. to establish an oral mastication training and texture and diet education program for the elderly who have poor chewing and eating ability after dentures are installed. 2. provide teaching programs tailored to the evidence-based and individualized needs of the elderly. 3. through the implementation of evidence-based oral mastication training and a texture and diet education program, the experimental group and the control group are expected to show variations in oral health, eating ability, nutrition, and physical function over time.

Eligibility criteria:
inclusion criteria: 1. residing in chiayi county who are 65 years of age or older 2. capable of self-care, conscious 3. able to communicate in mandarin and taiwanese. exclusion criteria: 1. non-residents of chiayi county 2. unable to take care of themselves or are unconscious 3. demented or mentally challenged and are unable to cooperate

Keywords: the elderly in the community oral health nutrition eating ability physical function technological oral health management dentures
an individualized-health elibrary app for people with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: the purpose of this study is to assess the effectiveness after using a new individualized-health e-library app named savvyhealth among people with multiple sclerosis.

participants will use our developed app for 21 days and take a before-use survey and a post-use survey.

Eligibility criteria:
inclusion criteria: * diagnosed with ms; * 18 years or older; * one comorbidity evaluated by a validated comorbidity questionnaire for people with ms; * willing to take a survey; * willing to use the app for 21 days; * willing to be assigned to either the intervention or control group. exclusion criteria: -

Keywords: ehealth mhealth
changes in circulatory i-fabp in elderly persons in daily life

Conditions: Malnutrition; Intestinal Integrity; Intestinal Fatty Acid Binding Protein (IFABP)

Summary: the purpose of this study is to detect changes in circulatory i-fabp values (50% increase) in elderly volunteers following the combination of moderate physical activity and a standard meal.


Eligibility criteria:
inclusion criteria: 1. age 75 years or older (both sexes) 2. participating in the embrace project. exclusion criteria: 1. previous gastrointestinal resections 2. chronic inflammatory gastrointestinal disease
pragmatic set of interventions versus scapular strengthening exercises on scapular dyskinesia in adhesive capsulitis

Conditions: Scapular Dyskinesis; Adhesive Capsulitis

Summary: the aim of this study is to determine the effects of pragmatic set of interventions versus scapular strengthening exercises on scapular dyskinesia in adhesive capsulitis.

scapular dyskinesia (sd) is a term that describes a physical impairment in which the scapula's position and motion are altered.symptoms of sd can be one or a combination of the anterior shoulder pain, postero-superior scapular pain, superior shoulder pain, proximal lateral arm pain. scapular dyskinesia is commonly found in adhesive capsulitis patients. to determine the scapular dyskinesia with shoulder pain two tests that apply manual assistance to the scapula are lateral scapular slide test and wall push up test. pragmatic set of interventions are an important element in rehabilitation, and has improved the treatment of many musculoskeletal and neurological conditions. scapular strengthening exercises, which aims to improve abnormal scapular movements that commonly occur in people with adhesive capsulitis. the purpose of this study is to explore the effect of scapular focused exercises on the rehabilitation of adhesive capsulitis, patient with scapular dyskinesia. the importance of scapular rehabilitation in the treatment of scapular dyskinesia and to examine the comparative effect of pragmatic set of intervention with scapular strengthening protocol on scapular dyskinesia. my study on the effect of a pragmatic set of intervention versus scapular strengthening exercises on scapular dyskinesia in adhesive capsulitis is important because it addresses a gap in the current literature. while both interventions have been shown to improve scapular dyskinesia in patients with adhesive capsulitis, there is a lack of studies comparing the two methods. my study will help determine which intervention is more effective in treating scapular dyskinesia, which will be valuable information for healthcare providers working with patients with adhesive capsulitis

Eligibility criteria:
inclusion criteria: * both male and females with age range b/w 25-45 * people with adhesive capsulitis (having pain, stiffness, and decrease movements of - external rotation, forward flexion and abduction) * scapular dyskinesia (positive lateral scapular slide with difference of 1.5cm when measurements are compared bilaterally) exclusion criteria: * history of shoulder surgery or other significant shoulder injury, neurological or musculoskeletal conditions that may affect shoulder function. * history of significant medical conditions (e.g., heart disease, cancer) that may affect their ability to participate in the study. * pregnant or breast feeder, as the exercise program may not be safe or appropriate for them.

Keywords: scapular dyskinesis adhesive capsulitis pragmatic set of interventions strengthening exercise
clomiphene citrate stair-step protocol

Conditions: Polycystic Ovary

Summary: a rct will be conducted to compare the traditional clomiphene citrate regimens for ovulation induction with the stair-step protocol. sixty women will be included after obtaining their written informed consent and will be randomized into either of the 2 groups.

this study is a randomized clinical trial (rct) will be conducted in ain shams university maternity hospital at infertility clinic within a period of 6-8 months. all patient are previously diagnosed as pcos according to the rotterdam conference of 2003. all patients will be devided according to computer based program into two groups first group: patients with traditional protocol traditional protocol: clomiphene citrate (clomid) (50mg) will be given for 5 days (days 3-7). transvaginal ultrasound from 9th-20th every other day if ovulation occur the patient will be excluded if no ovulation, we will wait for the next menses and increase the dose to (100mg). if no ovulation occurred increase the dose to (150mg) in the next cycle if no ovulation increase the dose to (200mg) tvus from 9th-20th ovary other day. if no ovulation we will wait for next cycle and increase the dose to (250mg) and so till 6 cycles . second group: patient with stair step protocol follicular development will be monitored using transvaginal ultrasound at 11-14 day after (50mg) clomiphene for 5 days if there is no response (no follicle \>10mm), so, (100mg) clomiphene will be initiated immediately for 5 days and ultrasound will be repeated 1 week after the first ultrasound. if there is no response, (150mg) clomiphene will be initiated immediately for another 5 days and tv/us will be performed 1 week after the second tv/us .

Eligibility criteria:
inclusion criteria: * age between 20-35 years. * body mass index (bmi/m2) 26-35 kg/m2 * normal hystrosalpingogram (hsg). * normal prolactin level. * normal semen analysis. exclusion criteria: * - they underwent ovarian drilling. * other factors infertility. * autoimmune diseases as thyroid disorders and systemic lupus erythematosus.

Keywords: clomiphene citrate stair- step poly cystic ovary
new media obesity treatment in community health centers

Conditions: Obesity

Summary: this purpose of this trial is to determine whether a 12-month ehealth behavioral intervention that includes interactive self-monitoring and feedback, tailored skills training materials, telephone counseling calls, and primary care physician (pcp) counseling will produce greater weight change at 12 months than a standard primary care control.

this is a patient randomized trial in which patients will be randomized into one of two treatment arms: 1) standard primary care; or 2) primary care plus a 12-month ehealth behavioral intervention (iota), which includes interactive self-monitoring and feedback, tailored skills training materials, 18 telephone counseling calls, and primary care provider counseling. the primary outcome is weight change at 12 months. participants will be 351 adult male and female patients from local community health centers with obesity and a related comorbidity.

Eligibility criteria:
inclusion criteria: * at least 1 visit in the previous 12 months to an adult medicine, internal medicine, or family practice provider at a participating community health center * bmi between 30.0-45.0 kg/m2 and weight ≤ 320 pounds * diagnosis of hypertension or diabetes exclusion criteria: * current pregnancy * pregnancy in previous 12 months * heart attack/stroke in previous 2 years * active cancer diagnosis * current participation in another weight loss study

Keywords: weight loss primary care ehealth
radiosurgery for drug resistant invalidating tremor

Conditions: Severe Upper Limb Tremor Refractory to Medical Therapy

Summary: stereotactic lesioning of thalamus and basal ganglia for treatment of tremor is a well-known procedure which, prior to the introduction of deep brain stimulation, or dbs, was usually achieved using stereotactic surgical procedures. radiosurgery of invisible targets to treat movement disorders and intractable pain are still the domain of frame-based procedures, due to the need of a solid reference system registered to the anterior commissure-posterior commissure (ac-pc) line, which allows the use of stereotactic atlases. in this study we want to utilize a mathematical method that uses atlas-derived stereotactic coordinates to perform frameless images-guided radiosurgery of such functional targets particularly the aim of the present study is to investigate both the efficacy and the safety of the methodology to treat upper limb and hand tremor in elderly or in patients which are not ot susceptible of surgical procedures. for these reasons a dose escalation prospective trial have been designed.


Eligibility criteria:
inclusion criteria: * patients affected by severe upper limb tremor refractory to medical therapy and who are candidate for a deep brain stimulation (dbs) procedure. * age: ≥ 18 years old * refusal of dbs procedure * written consent exclusion criteria: * pregnancy * allergy to contrast medium * dbs procedure susceptibility, if not refused
alendronate and/or parathyroid hormone for osteoporosis

Conditions: Osteoporosis

Summary: this study looks at the effects of two medications, alendronate and parathyroid hormone, on bone mass and on bone formation and bone breakdown in women with osteoporosis. we will randomly select postmenopausal women who have osteoporosis to receive laboratory-produced human parathyroid hormone (hpth), or alendronate, or both for 2.5 years. study participants will return to the study center periodically to have their bone mass measured and to give blood and urine samples for tests of bone formation and breakdown and for other laboratory tests. those who complete the study are eligible for one or two 12 month extension studies.

this is a randomized, prospective, open-label study in which osteoporotic postmenopausal women self-administer synthetic hpth-(1-34), alendronate, or both, every day for 2.5 years. participants initially come to massachusetts general hospital once a month, and subsequently once every 3-6 months, for measurements of serum and urine indices of bone formation and resorption, serum and urine toxicity tests, and dxa/qct measurements of bone mass. one-third of the participants take hpth-(1-34) daily, one-third take alendronate once daily, and one-third take both daily (phase a, months 0-30). participants who complete phase a are eligible for a 12 month extension study (phase b, months 30-42), during which any alendronate treatment is continued without change and any hpth 1-34 treatment is stopped. participants who complete phase b are eligible for a second 12 month extension study (phase c, months 42-54), during which any alendronate treatment is continued without change and every participant takes hpth 1-34. during phases b and c, these participants come to massachusetts general hospital once every 6 months for measurements of serum and urine indices of bone formation and resorption, serum and urine toxicity tests, and dxa/qct measurements of bone mass.

Eligibility criteria:
inclusion criteria: * lumbar spine or hip bmd t-score less than or equal to minus 2.0 * postmenopausal at least 5 years * fully ambulatory * able to give informed consent exclusion criteria: * no concurrent illnesses that cause bone loss * no recent drug treatment for osteoporosis * no recent fracture

Keywords: osteoporosis bone formation bone resorption parathyroid hormone (pth) postmenopause
local pilocarpine for relieving dry mouth

Conditions: Patients of Advanced Age (≥ 70 Years) With a Clinical Diagnosis of Chronic Dry Mouth

Summary: the investigators intended for this study to deliver the "proof-of-concept" that locally administered pilocarpine drops in two doses are effective in a population of elderly (aged ≥ 70 years) with xerostomia at the expense of limited adverse events. to this end, the study aims to quantify the effect size of pilocarpine in two different dosages. in case the investigators observe clinically meaningful changes in xerostomia through measured nrs, a sufficiently-powered rct will be prepared to compare pilocarpine to placebo.


Eligibility criteria:
inclusion criteria: * ≥ 70 years of age * clinical diagnosis of chronic dry mouth defined as a numeric rating scale (nrs) score ≥ 5 (scale 0 - 10, with 0 = no dry mouth and 10= worst possible dry mouth) on severity of xerostomia for more than 3 months. exclusion criteria: * existence of cognitive impairment and/or diagnosis of dementia appraised by treating physician * inability to fill out the questionnaires due to other reasons * prior radiation therapy of the head-and-neck region * known m. sjögren disease * contra-indications for parasympathicomimetics (uncontrolled asthma, acute heart failure, active peptic ulceration, known hypersensitivity to pilocarpine, and when miosis is undesirable, e.g., in acute iritis and in narrow-angle (angle closure) glaucoma.

Keywords: xerostomia pilocarpine advanced age (≥ 70 years)
reducing energy density by different methods to decrease energy intake

Conditions: Obesity

Summary: the purpose of this research is to investigate how using different methods to reduce the energy density of entrees affects daily energy intake in adults. it is hypothesized that reducing the energy density of entrees will decrease energy intake. it is also hypothesized that reducing the energy density by incorporating fruit and vegetables will decrease energy intake more than reducing the energy density by decreasing fat content or adding plain water.


Eligibility criteria:
inclusion criteria: * adults from penn state and surrounding community exclusion criteria: * currently dieting * food allergies
onset of labour epidural analgesia with different concentration bupivacaine and different doses of sufentanyl

Conditions: Pregnant Women Who Requested Epidural Analgesia in the Early Stage of Labor

Summary: this study aimed to compare the effects of three commonly used combination doses on the onset time and adverse reactions.

epidural block is widely used as an analgesic method during labor. during epidural anaesthesia, lipophilic opioids such as sufentanil, are often combined with local anesthetics to prolong the duration of analgesia and improve the analgesic effect. however, dose combinations of local anesthetics and opioids, especially in the initial loading dose, vary greatly from hospital to hospital and often depend upon the different routines adopted by anesthesiologists. in clinical practice, there are still some controversy about opioid dose selection in terms of analgesic onset time and adverse reactions. in this study, three combinations of bupivacaine and sufentanil were chosen, commonly used in the clinic, and extended the observation period to 24 hours after delivery. we hypothesized that increasing the concentration of local anesthetic, rather than increasing the dose of sufentanil, would achieve a faster analgesic effect with minimal adverse effects on the mother and fetus. to test our hypothesis, our primary outcome was to compare the times of analgesia onset of the three combinations, and the secondary outcomes were to compare the effects on maternal and infant adverse reactions.

Eligibility criteria:
inclusion criteria:patients asa physical status 1 or 2; early labour (cervical dilation 5 cm or less); singleton fetus; gestational age \> 36 weeks; and normal fetal heart rate (fhr) tracing. - exclusion criteria:severe preeclampsia;antepartum haemorrhage; asa 3 or more; chronic pain; substance abuse;contraindications to epidural analgesia; allergies to local anaesthetics or fentanyl; body mass index (bmi) over 40; and previous administration of opioid analgesia within 24 h. -
demojuan- demonstration area for primary prevention of type 2 diabetes, juan mina and barranquilla, colombia

Conditions: Type 2 Diabetes; Glucose Metabolism Disorders

Summary: the main aim of this study is to investigate to what extent it is possible to reach normal glucose metabolism and optimal cardiovascular disease (cvd) risk factor levels with early lifestyle interventions in people at high risk of type 2 diabetes compared with those who receive standard therapy (usual care) only. the project will show the effect of these interventions for the first time in people of low socio-economic levels living in a caribbean environment.

type 2 diabetes (t2d) is one of the fastest growing public health problems in both developed and developing countries. the development of t2d is a slow process and involves both genetic and environmental effects. it is commonly agreed that t2d may develop only in people that carry a genetic predisposition to the disease. based on epidemiological observations about half of the people will develop t2d during their lifetime, and up to 30-35% will have igt. therefore, it is likely that more than half of the population carry genes that predispose the development of t2d. in people genetically predisposed to the disease, the probability to develop t2d is very high once exposed to unhealthy lifestyles such as obesity, unbalanced diet and physical inactivity. while we cannot change the genes, the only way to prevent t2d and its serious complications is the modification of lifestyle risk factors. therefore, it is very important to understand the role of preventive lifestyle intervention as a key treatment in t2d prevention. once established, t2d is difficult to treat. despite pharmacologic treatment blood glucose levels trend to increase over time. thus, the most efficient way to manage t2d is to prevent diabetes from developing. also complications of t2d can best be postponed by postponing the onset of the primary disease itself. the efforts to prevent the disease need to start as early as possible and address all susceptibility factors. fortunately, recent studies have convincingly demonstrated that prevention of t2d is possible. this project will show for the first time how lifestyle interventions work in people with igt in the caribbean population. the results of this study will be sued for policy making and planning of primary prevention activities not only in the local health-care system but in the entire caribbean region.

Eligibility criteria:
inclusion criteria: * 34-69 years-of-age with diagnosed igt * informed consent given. exclusion criteria: * patients with pharmacologically-treated diabetes * hypertriglyceridaemia under drug treatment * history of life-limiting diseases or events * unwillingness to sign the informed consent.

Keywords: impaired glucose tolerance nutrition physical activity
obinutuzumab with chop versus obinutuzumab with bendamustine in the treatment of newly diagnosed follicular lymphoma grade 3a

Conditions: Follicular Lymphoma Grade 3A

Summary: this is a multicenter, phase 2, randomized trial to evaluate the efficacy and safety of obinutuzumab with chop versus obinutuzumab with bendamustine in treatment-naïve follicular lymphoma (grade 3a) patients.


Eligibility criteria:
inclusion criteria: 1. histologically confirmed follicular lymphoma grades 3a, cd20 positive by immunohistochemistry. 2. meets at least one gelf (groupe d'etude des lymphomes folliculaires) criteria. 3. no prior systemic treatment for lymphoma. 4. presence of measurable lesions. 5. age ≥ 18 years, no gender restriction. 6. eastern cooperative oncology group (ecog) performance status of 0, 1, or 2. 7. expected survival of \> 3 months. 8. adequate organ and bone marrow function. exclusion criteria: 1. history of allergy to any component of monoclonal antibodies or investigational drugs. 2. central nervous system involvement. 3. history of previous malignant tumors. 4. history of active bleeding or bleeding tendencies, or requiring anticoagulant medication. 5. requirement for potent cyp3a4 inhibitors for treatment. 6. active infection, except for tumor-related b symptoms. 7. known history of human immunodeficiency virus (hiv) infection and/or acquired immunodeficiency syndrome (aids). 8. hepatitis c virus (hcv) antibody positive with hcv rna quantitative test result exceeding the detection limit; hepatitis b surface antigen (hbsag) positive or hepatitis b core antibody (hbcab) positive, with hepatitis b virus dna quantitative test result exceeding the detection limit (for patients with hbsag or hbcab positive status, regardless of hbv-dna detection, oral entecavir or other antiviral therapy must be initiated prior to enrollment and continued according to the physician's instructions during the trial). 9. significant organ dysfunction or uncontrolled comorbidities, such as uncontrolled hypertension, decompensated cirrhosis, uncontrolled diabetes, chronic obstructive pulmonary disease, etc. 10. history of severe heart disease. 11. major surgery within 4 weeks prior to enrollment. 12. participation in other clinical trials with drug intervention within 4 weeks prior to enrollment. 13. pregnant or breastfeeding women, or planning to become pregnant during the study. 14. individuals with psychiatric disorders, history of alcohol or drug abuse, or inability to provide informed consent. 15. investigator determines the patient is unsuitable for enrollment or may not be able to complete the trial for other reasons.