Kornimate/medical-research-clean huggingface dataset:
distal renal denervation to prevent renal function decline in patients with t2dm and hypertension

Conditions: Type 2 Diabetes Mellitus; Hypertension

Summary: the aim of this study is to test the hypothesis that distal renal denervation (rdn) may delay or prevent the progressive decline of renal function in patients with type 2 diabetes mellitus and hypertension

detailed description: diabetes mellitus and hypertension are two major causes of chronic kidney disease (ckd) that starts as subclinical decline in renal function that silently progresses to symptomatic advanced stages associated with irreversible significant damage of the kidney structure. recent major improvements in pharmacotherapy of hypertension and diabetes have substantially reduced the prevalence of cardiovascular complications, yet, the frequency of ckd remains largely unchanged. renal denervation is a new minimally invasive method to create regional blockade of the renal sympathetic nerves that is currently used as non-pharmacological therapy of hypertension. the ckd is likewise mediated by overactivity of renal sympathetic system so that rdn has strong potential to prevent development or progression of ckd. the new anatomically optimized distal rdn may have additional benefit in this regard. denervation of the distal vessels involved in tonic regulation of renal blood should cause a significant drop in renal vascular resistance and proportional increase in blood and oxygen supply to the kidney preventing/reducing chronic hypoxia of renal tissue that is major mechanism of ckd. the aim of this study is to prove the aforementioned concept. for this purpose the eligible patients with type 2 diabetes mellitus and hypertension will undergo distal renal denervation performed using dedicated radiofrequency catheter symplicity spyral. the changes in the kidney function and structure as well as bps (office and ambulatory) will be assessed at baseline, 6 and 12 months post-procedure

Eligibility criteria:
inclusion criteria: * informed consent of participation in the study; * systolic bp \> 140 or diastolic bp \> 90 mm hg; * type 2 diabetes mellitus (glucose tolerance test \> 11.0 mmol/l, hba1c\>6,5%); exclusion criteria: * secondary hypertension; * type 1 diabetes mellitus; * acute renal failure; * traumatic kidney injury; * toxic kidney injury; * ckd g4 and g5 according to the kdigo 2012; * infectious diseases requiring active antibacterial and/or antiviral therapy; * other severe diseases and conditions

Keywords: hypertension diabetes mellitus kidney renal function denervation blood pressure
glycaemia and cardiac function in patients with covid-19

Conditions: Diabetes Mellitus; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type 1; COVID

Summary: the study design is observational, exploratory study consisting of two cohorts of covid-19 patients admitted to the icu and the medical ward, respectively. the primary outcome focusing on the effect of plasma glucose levels on cardiac function will be evaluated by repeated assessment of cardiac function by echocardiography and measurement of plasma glucose. furthermore, blood coagulability will be evaluated to determine the importance of diabetes status and plasma glucose changes for whole blood coagulability at time of admission to the icu and progression in coagulability abnormalities. in the medical ward cohort, two assessments will be performed separated by no more than 12 hours. in the icu cohort, three assessments will be performed separated by no more than 6 hours. ideally, 60 patients with covid-19 will be included in the icu cohort with a 1:1 distribution between patient with and without diabetes. ideally, 40 patients with diabetes will be included in the cohort of patients admitted to medical ward (hospitalisation cohort). the primary hypothesis is that levels of plasma glucose have clinically significant impact on left ventricular systolic function in patients with covid-19 admitted to the icu. the secondary hypothesis is that the impact of plasma glucose on left ventricular systolic function is associated with glycaemic control prior to admission as measured by hba1c.


Eligibility criteria:
the icu cohort - inclusion criteria * informed and written consent * age ≥18 years * verified covid-19 * admission to the icu within the last 24 hours * type 1 or type 2 diabetes prior to admission (the diabetes sub-group only) the icu cohort - exclusion criteria * cardiac arrhythmia at time of inclusion (previously diagnosed paroxysmal atrial fibrillation will be allowed) * pacemaker rhythm * severe valve disease the hospitalisation cohort - inclusion criteria * informed and written consent * age ≥18 years * verified covid-19 * admission to medical ward within the last 24 hours * type 1 or type 2 diabetes prior to admission the hospitalisation cohort - exclusion criteria * cardiac arrhythmia at time of inclusion (previously diagnosed paroxysmal atrial fibrillation will be allowed) * pacemaker rhythm * severe valve disease withdrawal criteria - the participants may withdraw at will at any time
predictive factors for the diagnosis of early noninvasive ventilation equipment

Conditions: Amyotrophic Lateral Sclerosis

Summary: to compensate for insufficiency of diagnostic tools, the present study propose to look for the predictive factors of an early fitting by noninvasive ventilation.

amyotrophic lateral sclerosis (als) is the most common motor neuron disease. the diagnosis of this diaphragmatic dysfunction in the als subject is done all too often on the occasion of a hospitalization for acute respiratory insufficiency, which aggravates then the prognosis of the patients. the presence of these factors at diagnosis will allow more surveillance to detect early diaphragmatic insufficiency and establish a niv (non invasive ventilation), the only therapeutic measure definitely improving the quality of life and survival of patients. a clinical score will be established to determine the risk of early non invasive ventilation (niv) equipment.

Eligibility criteria:
inclusion criteria: * diagnosis of amyotrophic lateral sclerosis just performed, * patient who do not have the criteria for fitting by niv and who have a vital capacity ≥ 70% of theoretical values exclusion criteria: * patient under court bail/ guardianship * lack of consent for participation in the study * presence of criteria for setting up the niv for diagnosis according to the has (healthcare analytics summit) 2006 recommendations * vital capacity \<70% of the theoretical values * patient under continuous positive pressure (cpp) or niv for a respiratory pathology other

Keywords: diagnostic criteria
gut microbiota stunted children ntt

Conditions: Stunting

Summary: ntt province is on the list of priority areas of high prevalence of stunting, southwest sumba, south middle east, and kupang district have a stunting prevalence of 36.2%, 34.5% and 48.1% respectively in 2020. therefore, it is necessary to conduct a profile study. microbiota, scfa, gastrointestinal integrity, parasites, hygiene practice, and cognition in stunting and healthy toddlers in the province of east nusa tenggara,

stunting indicates a public health problem because it is associated with an increased risk of morbidity and mortality, decreased motor and mental function development, and reduced physical capacity. stunting is a chronic nutritional deficiency condition that affects the growth and development, and intelligence of children. lack of nutrients can cause intestinal microbiota dysbiosis where this will reduce the metabolism of short chain fatty acids (scfa) which will affect the absorption of nutrients in the small intestine and cause impaired immunity, which in turn worsens stunting conditions. the composition of the gut microbiota is influenced by age, sex, geographic area and food intake. therefore, the description of knowledge, attitudes and applications in society, especially mothers and child subjects, was also analyzed using a hygiene practice questionnaire. the aim of the study was to obtain an overview of the gut microbiota, gastrointestinal integrity, parasitic infections, hygiene practices and cognitive scores in stunting and healthy toddlers in several areas in the province of east nusa tenggara as a baseline study to be followed up by intervention study. the research will be conducted for 3 (three) months in 2021/2022. the subjects involved represented 100 stunted children and 100 healthy children aged 36-45 months from each region. determination of the sample with a sampling quota. the variables studied were the nutritional status of under five years children, characteristics of children under five (age, gender, birth weight (bbl), birth length, breast feeding history, immunization history, history of diarrhea, history of ari (upper respiratory tract infection)), mother and family characteristics (age, education). , occupation, father's occupation, total family income), home environment and hygiene, vaccination history, gastrointestinal microbiota status, gastrointestinal integrity, parasites, hygiene practices, and cognitive scores.

Eligibility criteria:
inclusion criteria: * anthropometric measurements of stunting were measured based on the parameters of length/height according to age compared to the 2005 who anthropometric standards and the indonesian ministry of health decree no. 1995/menkes/sk/xii/2010. exclusion criteria: * criteria thats makes subject appropiate, like more than 5 years old, not live in sampling area, unhealthy

Keywords: stunting gut microbiota toddler scfa parasite hygiene practice
cardiac amyloidosis prevalence and outcome in aortic stenosis patients undergoing transcatheter aortic valve implantation

Conditions: Aortic Stenosis

Summary: aortic stenosis (as) is the most frequent valvulopathy in the general population in france and more generally in developed countries, due to populations aging. its standard treatment is historically surgical aortic valve replacement (savr). in the 2000s, the management of this valvulopathy was revolutionized by the development of the technique of per-cutaneous aortic valve replacement (tavi). tavi opens the possibility of curative treatment to patients at high operational risk not operable by conventional surgery, and for whom outcome was affected with high mortality under medical treatment alone. amyloidosis, a pathology with multiple etiologies, is a rare condition and its cardiac form (ac) even more (8 to 17 / 100,000 people / year). however, its prevalence is increasing. some autopsies series have found prevalence up to 50% of cardiac amyloidosis with transthyretin (ac-ttr) after 60 years. in addition, recent data suggested that ac-ttr prevalence is higher in the population of patients with heart disease: 13% in heart failure with preserved ejection fraction and up to 16% in patients with as. the outcome of patients with ac-ttr remains unknown after tavi. thus, the diagnosis of ac-ttr in patients undergoing tavi represents an important issue. indeed, a treatment stabilizing the process of accumulation of transthyretin deposits, effective on the survival of these patients, is now available. in addition, a non-invasive screening strategy for ac-ttr, alternative to biopsy, is now validated.

the aim of the study is to describe prevalence of cardiac amyloidosis with transthyretin in patients undergoing transcatheter aortic valve implantation.

Eligibility criteria:
inclusion criteria : * patients over 60 years old * patients admitted in reims university cardiology department for per-cutaneous aortic valve replacement due to severe aortic stenosis * patients enrolled in the national healthcare insurance program * patients consenting to participate to the study exclusion criteria : - al amyloïdosis patients

Keywords: cardiac amyloïdosis aortic stenosis transthyretine amyloïdosis ca-ttr transcatheter aortic valve implantation tavi prevalence outcome survival
intraoperative laser speckle contrast imaging of cerebral blood flow

Conditions: Aneurysm, Brain; Arteriovenous Malformation of Brain; Neurovascular Disorder

Summary: the purpose of this research study is to evaluate the ability of laser speckle contrast imaging to visualize blood flow in real time during neurosurgery. real-time blood flow visualization during surgery could help neurosurgeons better understand the consequences of vascular occlusion events during surgery, recognize potential adverse complications, and thus prompt timely intervention to reduce the risk of stroke. the current standard for visualizing cerebral blood flow during surgery is indocyanine green angiography (icga), which involves administering a bolus of fluorescent dye intravenously and imaging the wash-in of the dye to determine which vessels are perfused. unfortunately, icga can only be used a few times during a surgery due to the need to inject a fluorescent dye, and provides only an instantaneous view of perfusion rather than a continuous view. laser speckle contrast imaging does not require any dyes or tissue contact and has the potential to provide complementary information to icga. in this study we plant to collect blood flow images with laser speckle contrast imaging and to compare the images with icga that is performed as part of routine care during neurovascular surgical procedures such as aneurysm clipping.


Eligibility criteria:
inclusion criteria: * adults (18 years or older). * size of craniotomy at least 2 cm. * possibility of intraoperative icga. * able to render written informed consent. exclusion criteria: * patients unable to legally consent. * patients with impaired cognitive function.
point-of-care rbc washing to prevent transfusion-related pulmonary complications

Conditions: Blood Transfusion Complications

Summary: this study is designed to determine if point-of-care washing of allogeneic leukocyte-reduced red blood cells reduces pulmonary complications when compared to standard-of-care leukocyte-reduced red blood cells in a cardiac surgical population.


Eligibility criteria:
inclusion criteria: * age equal to or greater than 18 years of age. * scheduled to have cardiac bypass surgery at mayo clinic in rochester, minnesota or duke university medical center in durham, north carolina * at risk for needing at least 4 units of blood during/after surgery exclusion criteria: * emergency surgery * immunoglobulin a (iga) deficiency * history of severe recurrent transfusion reactions * refusal to receive allogeneic blood products * refusal to provide informed consent * prevalent lung injury prior to randomization * prevalent congestive heart failure prior to randomization * expected hospital stay \< 48 hours * not anticipated to survive \> 48 hours * previously enrolled in this trial * no plan for placement of a pulmonary artery catheter * use of home oxygen therapy * complex rbc antibody profiles * need for the use of irradiated rbcs

Keywords: transfusion rbc cardiac surgery transfusion related acute lung injury (trali) transfusion associated circulatory overload (taco)
study of the carpal tunnel syndrome in relation to stress and depression among medical students

Conditions: Carpal Tunnel Syndrome (CTS)

Summary: participants will undertake validation of the median nerve and their anxiety and depression levels. possible correlation will be searched.

medical students of the university of ioannina will be submitted to ultrasound of the medial nerve as to assess its surface. those with pathological findings will undertake a non-interventional electromyography test. afterwards they will complete anonymously two validated tests regarding depression and anxiety (yung ans stai scales). statistical analysis will be conducted with the question of correlation between median nerve dysfunction and psychiatric disorders.

Eligibility criteria:
inclusion criteria: * medical students exclusion criteria: * known pathology of the carpal joint

Keywords: carpal tunnel syndrome anxiety depression medical students
comparison of effects of mirror therapy combined with neuromuscular electrical stimulation or binaural beats stimulation on cortical excitability, heart rate variability and lower limb motor function in patients with stroke

Conditions: Stroke; Healthy Adults

Summary: this study aims to compare the effects of mirror therapy combined with either neuromuscular electrical stimulation or binaural beat stimulation on post-stroke lower limb motor function recovery. the study also explores the relationship between patients' cortical excitability and motor function improvement.


Eligibility criteria:
inclusion criteria: 1. first occurrence of stroke≧ 6 months 2. mini-mental state examination≧24 3. modified ashworth's scale of ankle muscle ≦3 4. sit independently≧30 mins 5. brunnstrom stage ≧3 6. aged between 20 and 80 years exclusion criteria: 1. speech impairment 2. hearing impairment 3. visual impairment 4. other orthopedic diseases or nerve damage 5. complete sensory impairment 6. pacemaker or metal implants
myofascial pain syndrome and dextrose prolotherapy

Conditions: Efficacy of Dextrose Prolotherapy in Myofascial Pain Syndrome

Summary: myofascial pain syndrome is characterized by the presence of hypersensitive points called trigger points that cause pain, tenderness, spasm, stiffness, limitation of movement, weakness, taut band within the muscle, and pain reflected by pressing in a muscle group or a single muscle. prolotherapy is a regenerative treatment method in the treatment of chronic musculoskeletal pain, in which an irritating solution is injected, often hypertonic dextrose, into painful ligament and tendon attachments and adjacent joint spaces. in this study, it was aimed to examine the effect of prolotherapy application on pain, neck range of motion and neck disability in women with myofascial pain syndrome.


Eligibility criteria:
inclusion criteria: * 60 women aged 20-50 years with a diagnosis of myofascial pain syndrome exclusion criteria: * cervical radiculopathy, cervical degeneration, neck surgery or trauma in the last year, injection history for myofascial pain syndrome in the last 6 months, cognitive impairment and fibromyalgia, rheumatoid arthritis, hypothyroidism, diabetes mellitus

Keywords: myofascial pain, dextrose prolotherapy, neck disability
the role of genetic factors in the development of myocardial infarction in the kazakh population

Conditions: Heart Attack

Summary: this is a gwas study that aims to identify possible candidate genes associate to heart attack by exploring single nucleotide polymorphism (snp) in a group of heart attack, in the kazakh population. the investigators hypothesize that the careful phenotyping of the subject sand matching with increase the power to find snp significantly associate with heart attack

a genome-wide association study (gwas) is an approach used in genetics research to associate specific genetic variations with particular diseases. the method involves scanning the genomes from many different people and looking for genetic markers that can be used to predict the presence of a disease. once such genetic markers are identified, they can be used to understand how genes contribute to the disease and develop better prevention and treatment strategies.

Eligibility criteria:
inclusion criteria: * persons of kazakh nationality * age up to 59 years inclusive at the time of primary myocardial infarction * myocardial infarction was established in accordance with the eoc criteria: an increase and / or decrease in the level of cardiac troponin must be combined with at least one of the following: • symptoms of myocardial ischemia • newly occurring ischemic changes on the ecg • the appearance of a pathological q wave • identification according to imaging data methods of new areas of non-viable myocardium, or new areas of local contractility disorders of presumably ischemic etiology • detection of a thrombus in the coronary arteries according to coronary angiography * presence of coronary angiography * persons able and willing to provide written informed consent; exclusion criteria: * age at primary myocardial infarction 60 years and older * heart defects, congenital and acquired * non-ischemic cardiomyopathies * autoimmune diseases * diabetes mellitus at the time of development of primary myocardial infarction * terminal stages of renal and hepatic failure

Keywords: gwas
project heals (helping and empowering patients for living a life smoke-free

Conditions: Smoking; Tobacco Use; Lung Cancer

Summary: the purpose of the study is to pilot test a multi-modal smoking cessation and relapse prevention intervention with the lung cancer patient population and to obtain preliminary data on its feasibility.


Eligibility criteria:
inclusion criteria: * 18 years of age or older * smoked at least 100 cigarettes in lifetime * current smoking (defined as self-report of any smoking, even a puff, in the past 30 days) * diagnosis of lung cancer * able to read and write english * not currently enrolled in a smoking cessation program * has a working telephone * has a valid home address exclusion criteria: * current use of tobacco cessation medications * another household member enrolled in this study * contraindication of nicotine patch, unless under the supervision of a physician as advised by project staff * moffitt clinical trial participant at time of enrollment
a study on the potential of aleglitazar to reduce cardiovascular risk in patients with stable cardiovascular disease and glucose abnormalities

Conditions: Cardiovascular Disease, Diabetes Mellitus Type 2

Summary: this randomized, double-blind, placebo-controlled, parallel group, multicenter study will evaluate the potential of aleglitazar to reduce cardiovascular risk in patients with stable cardiovascular disease and glucose abnormalities. patients will be randomized 1:1 to receive either aleglitazar 150 mcg orally daily or matching placebo.


Eligibility criteria:
inclusion criteria: * male and female patients with established evidence of stable cardiovascular disease (cvd) defined as at least one of the following groups of criteria (a or b) a. age \>/= 40 years with history with prior cv event of prior myocardial infarction or prior ischemic stroke (confirmed by brain imaging study), with onset \>/= 3 months prior to randomization and stable in the investigator's judgment b. age \>/= 55 years with evidence of cvd (stable in the investigator's judgment), defined as at least one of the following: coronary disease, cerebrovascular disease or peripheral arterial disease as defined by protocol * patients with glucose abnormalities based on one of the following a-b criteria: a. established type 2 diabetes mellitus (t2d) according to 2010 ada criteria; treatment may include diet alone, or any glucose-lowering therapies except for thiazolidinediones (tdzs) b. no fulfillment of criterion a) but evidence of glucose abnormalities * optimal management of cv risk factors including hypertension and dyslipidemia as informed by the best evidence and clinical practice guidelines exclusion criteria: * current treatment with a thiazolidinedione (tdz) or fibrate * prior intolerance to a tdz or fibrate * previous participation in a trial with aleglitazar * other types of diabetes * inadequate liver, hematologic or renal function * symptomatic heart failure classified as nyha class ii-iv * hospitalization for a primary diagnosis of heart failure in the 12-month period preceding randomization * peripheral edema which in the judgment of the investigator in believed to be severe and of cardiac origin * history of surgical coronary revascularization (cabg) less than 5 years prior to screening, except in cases of subsequent myocardial infarction * currently scheduled for arterial revascularization procedures * systemic corticosteroid therapy for \> 2 weeks within 3 months prior to screening * diagnosed or treated malignancy (except for treated basal cell skin cancer, in situ carcinoma of the cervix, or in situ prostate cancer) within the past 5 years