Kornimate/medical-research-clean huggingface dataset:
efficacy/safety of hcp1306 tablet versus hgp0816 tablet in patients with primary hypercholesterolemia

Conditions: Primary Hypercholesterolemia

Summary: the purpose of this study is to evaluate efficacy and safety of hcp1306 in patients with primary hypercholesterolemia.


Eligibility criteria:
inclusion criteria: * aged over 19 years * signed informed consent * at visit 1, ldl-c ≤ 250mg/dl and triglyceride \< 400 mg/dl * after 4 weeks more tlc, at visit2, ldl-c ≤ 250mg/dl, triglyceride \< 400 mg/dl and satisfied criteria according to risk of cardiovascular disease exclusion criteria: * current or past history of hypersensitivity to hmg-coa reductase inhibitors and component of ezetimibe * has an active liver disease and severe liver disorder (continous elevation of ast, alt level or exceeds more than 3 times of normal upper limit) * has a severe renal failure and kidney injury (creatinine level exceeds more than 2 times of normal upper limit) * ck level exceeds more than 5 times of normal upper limit * uncontrolled hypertension patient (sbp≥ 180 mmhg or dbp ≥ 110 mmhg) * uncontrolled diabetes mellitus patient (hba1c ≥ 9%) * uncontrolled malfunctional thyroidism (or at pre-visit 2, tsh level exceeds more than 1.5 times of normal upper limit)
efficacy of intraoperative surgical scrubbing in reducing bacterial load after nail removal surgery

Conditions: Skin Diseases; Nail Diseases; Nails, Ingrown

Summary: the investigators conducted a controlled, prospective randomized study to examine the antiseptic efficacy of intraoperative irrigation methods during nail avulsion surgery.

the investigators conducted a controlled, prospective randomized study to examine the antiseptic efficacy of intraoperative scrubbing methods during nail avulsion surgery. the investigators compared intraoperative antiseptic scrubbing using 0.9% saline solution and 0.1% polihexanide. swab samples were taken from each patient at 5 distinct stages throughout the surgical procedure, and bacterial culture analysis was performed (positive culture rate, total inocula count, reduction of bacterial load, and identification of specific microorganisms).

Eligibility criteria:
inclusion criteria: * older than 18 * onychocryptosis exclusion criteria: * infection * a history of tinea pedis * onychomycosis * paronychia * nail trauma or subungual hematoma * nail deformities and disorders * peripheral vascular disease or diabetes * cardiac disease * a history of rheumatic fever * recent antibiotic use or current antimicrobial therapy * a history of steroid use and * recent nail polish use

Keywords: skin diseases [c17.800] nail diseases [c17.800.529] nails, ingrown [c17.800.529.406]
comparison of the effect of lumbar spinal manipulation, physical therapy and surgical management in the treatment of lumbar spinal stenosis

Conditions: Lumbar Spinal Stenosis; Spinal Manipulation; Physical Therapy; Surgery

Summary: to compare the effect of lumbar spinal manipulation, physical therapy and surgical management in the treatment of lumbar spinal stenosis.

low back pain (lbp) is a very common health problem which results in negative impact in daily life and burden especially in elderly. the global age-standardized point prevalence of lbp in 2010 was estimated to be 9.4%. among the etiologies of low back pain, lumbar spinal stenosis is frequently encountered by physicians. in a large observational study, the prevalence of lumbar spinal stenosis was 23.6% in the general population and higher in patients more than 60 years-old. if untreated, the symptoms may persist in 70% of the patients over the 48-month observation period. on the other hand, previous studies have shown that surgery is more effective in pain relief, neurological symptoms and further functional status, however, conservative treatment still had favorable effect in patients with milder symptoms. the role of spinal manipulation has been discussed in previous study which compared the clinical efficacy of spinal manipulation against microdiskectomy in patients with sciatica secondary to lumbar disc herniation. according to this study, the pain, disability and life quality of both groups in 12-week period had no significant difference that chiropractic spinal manipulative treatment could be considered as a primary treatment. however, comparison among the effect of spinal manipulation, physical therapy, and surgery has not been conducted before. therefore, the purpose of this study is to compare the effect of spinal manipulation, physical therapy, and surgery in the treatment of lumbar spinal stenosis.

Eligibility criteria:
inclusion criteria: 1. age between 20 to 80 age years old 2. moderate to severe low back painand/or sciatica,and/or intermittent claudication (vas\>=4) 3. symptom duration is more than three months 4. the diagnosis is proved by mri exclusion criteria: 1. serious spinal pathologies including spinal tumor, infection, andinflammatory disease 2. progressive weakness, sensory loss or symptoms and signs suggesting cauda equine esion 3. concomitant serious medical conditions 4. history of spinal surgery before 5. severe osteoporosis or instability of the lumbar spine

Keywords: lumbar spinal stenosis spinal manipulation physical therapy surgery
the effect of mental fatigue on lower limb functional performance tests and brain activity in a healthy population

Conditions: Mental Fatigue; Return to Sport; EEG; Brain Activity; Functional Performance

Summary: objective of the study the main objectives of this project are: 1. to assess the influence of mental fatigue on a return-to-play test battery in healthy population 2. to assess the influence of mental fatigue on brain functioning during a balance and reaction time task in healthy population in a later stage, these experiments could be carried out in a clinical context (e.g. in an ankle sprain population). the researchers will use a randomized, placebo controlled, counter-balanced, cross-over design. thirteen healthy subjects will visit the lab 3 times. on the first visit (familiarisation trial), the investigators will collect the participants' characteristics. the participants will also be familiarized to the procedures and materials of the experiment during this first visit. the second and third visit contain the experimental setup and will proceed as follows: first, the participants will fill in a mental fatigue scale (m-vas) and motivation scale. next, the subjects will carry out a functional test battery (hop test, vertical jump test, y-balance test, and a balance reaction-time test). session rate of perceived exertion (rpe) is measured to indicate how fatigued the participants feel because of the test battery; also, m-vas is collected once more. then, a short cognitive task (flanker task) is followed by either a long intensive cognitive task (90 minutes stroop task) or control task (90 minutes documentary). afterwards, participants have to carry out the flanker task, fill in m-vas (2x), perform the same test battery, fill in session rpe and one final fatigue scale (nasa tlx). heart frequency and eeg will be measured continuously during the trials.


Eligibility criteria:
inclusion criteria: * healthy (no neurological/cardiorespiratory/psychological disorders) * male and female * no medication * non-smoker * between 18 and 35 years old exclusion criteria: * back and/or lower extremity injuries during the past 6 months * bone/joint abnormalities * dizziness, history of loss of consciousness, any inner ear disorders * nervous system disorders or dysfunctions * uncorrected eye disorders/dysfunctions * illness * use of medication or any kind of drugs * use of alcohol, caffeine and heavy efforts 24 hours before each trial * not eating the same meal the night before and the morning of each trial
surgery and exercise versus exercise only for chronic patellofemoral pain syndrome

Conditions: Patellofemoral Pain Syndrome; Tibial Tubercle Transfer; Home Exercise Program

Summary: the goal of this randomised controlled trial is to compare a tuberositas transposition (ttt) surgery with a home exercise program (hep) in patients with patellofemoral pain syndrome (pfps). the study aims to evaluate the efficiency of ttt in conjunction with a hep compared to a hep alone in patients with chronic pfps. participants will randomly be allocated to the surgery or hep group. researchers will compare the surgery and hep groups to see if activity-related pain and patient reported outcome measures (proms) are different.


Eligibility criteria:
inclusion criteria: * characteristic history of pfps (patellofemoral pain during knee loading physical activity, such as jumping, running, squatting); * symptoms lasting at least 12 months; * tibial tubercle trochlear groove (tt-tg) distance of 15mm or more on ct or mri; * patellofemoral pain during daily life activities, such as: standing for an extended period, walking, or walking upstairs or downstairs exclusion criteria: * previous knee surgery; * reported knee ligamentous or meniscal injuries; * disabling general illness; * a history of patellar dislocation; however, subjects with patellar subluxation are included in the study; * other knee problems than pfps diagnosed clinically (such as jumper's knee); * other knee problems than pfps diagnosed radiographically (such as osteochondritis - dissecans); * patients who cannot undergo surgery; * pregnancy; * patients with inability to complete follow-up or with limited understanding of the dutch language
correlation between quality of life and severity of parkinson's disease

Conditions: Parkinson Disease; Quality of Life

Summary: this study aim to evaluate the correlation between quality of life (qol) and severity of parkinson's disease (pd) by assessing the presence of an optimal cut-off point on the parkinson's disease questionnaire (pdq-39) as related to the hoehn \& yahr (h\&y) scale in a cohort of italian adults with pd. a multicenter, cross-sectional study was performed in central and northern italy. this study was conducted on a cohort of consecutive individuals at three neurologic outpatient clinics. all participants were evaluated with the pdq-39, and the severity of pd was recorded according to the h\&y scale by a neurologist. receiver operating characteristic (roc) curves and coordinates of the curve, which were visually inspected, were used to find cut-off points with optimal sensitivity and specificity. these were in turn used to determine the optimal pdq-39 cut-off score for identifying disease severity according to h\&y stages.


Eligibility criteria:
inclusion criteria: * age \> 50 but \< 90 years, * h\&y stages i, ii, iii, and iv, * a mini-mental state examination \> 22 points, * a minimum level of five years of education. exclusion criteria: * individuals with emotional or psychiatric problems (as determined by clinical screening)
effects of self-stretching and aerobic exercise in gestational diabetes.

Conditions: Gestational Diabetes

Summary: : gestational diabetes is a common pregnancy-related condition characterized by impaired glucose metabolism. it poses risks to both maternal and fetal health. physical activity interventions, such as self-stretching and aerobic exercise, have shown potential in improving glycemic control and managing associated symptoms in individuals with diabetes. objective: to determine the effects of self-stretching, with or without aerobic exercise, on glycemic control, fatigue, and stress for women with gestational diabetes

a randomized controlled trial was conducted at khursheed majeed hospital lahore and was completed in 8th month after approval of synopsis .a sample of 24 women having age 20 to 40 with gestational diabetes were selected through non probability convenience sampling technique and then randomly allocated into group a(self-stretching with aerobic exercise) and group b (self-stretching without aerobic exercise). the outcome measures were glycemic control, assessed by measuring fasting and postprandial blood glucose levels using a glucometer fatigue and stress levels, measured by fatigue assessment scale (fas) and perceived stress scale (pss), respectively. these measures will be obtained at baseline and after the 7-weeks intervention period. all participants in both groups were evaluated before and after the treatment programs. data was analyzed by using spss 25. results: mean value of fasting blood glucose pre-treatment (mean difference=0.05) and post treatment (mean difference=0.14) with p value \<0.05. mean value of 2 h postprandial blood glucose pre-treatment (mean difference=0.04) and post treatment (mean difference=0.20) with p value \<0.05.mean value of fatigue assessment scale pre-treatment (mean difference=1.56) and post treatment (mean difference=4.21) with p value \<0.05. mean value of perceived stress scale pre-treatment (mean difference=1.05) and post treatment (mean difference=4.74) with p value \<0.05 conclusion: the study concluded that both groups aerobic exercises + self-stretching (experimental group) and self-stretching exercises only (control group) improve glycemic control, reduce fatigue and stress in gestational diabetes. however aerobic exercises + self-stretching is more effective than self-stretching only

Eligibility criteria:
inclusion criteria: * age 20 -40. * weight: 70kg-100kg. * women diagnosed with gestational diabetes. * second and third trimester of pregnancy exclusion criteria: * females having history of depression * thyroid problems * preexisting diabetes • early onset diabetes * multiple pregnancies

Keywords: aerobic exercise, fatigue stress gestational diabetes glycemic control self-stretching
effectiveness of the collaborative community clinic for persons with spinal cord injury and disease

Conditions: Spinal Cord Injuries

Summary: the investigator is evaluating data stored on the collaborative community clinic data repository (irb #201811032). researchers seek to evaluate the effectiveness of the collaborative community clinic (ccc), an occupational therapy student experiential learning clinic for uninsured or under-insured people with spinal cord injury and disease (sci/d), using participants' initial and follow-up assessment batteries.

all data reviewed will be pulled from the collaborative community clinic (ccc) data repository according to the data manual and procedures. a separate irb was approved to review outcomes from participants in the ccc to evaluate the effectiveness of the clinic. all participants participated in an informed consent process to provide the option to have their data stored in a data repository for aggregate review. if any participate chooses not to have their data stored, it will not be stored or outcomes reviewed. however, participants are still provided services through the ccc. researchers anticipate up to 200 participants participating in the registry over five years. all data will be data checked by a member of the research team to limit errors and identification of missing data recorded. statistical analysis methods are to be determined upon completion of the study.

Eligibility criteria:
inclusion criteria: * 18 years of age; diagnosis of spinal cord injury or disease, un-insured or under-insured for occupational therapy services exclusion criteria: * under 18 years of age, lack of sci/d diagnosis, full insurance coverage for ot services (ie. medicare or private insurance)
c-cog in early course schizophrenia study

Conditions: Schizophrenia

Summary: the purpose of this study is to examine the role of clinical stability in functional recovery. in first episode schizophrenia.


Eligibility criteria:
inclusion criteria: 1. adults 2. diagnosis of schizophrenia 3. current hospitalization or outpatient relapse 4. fewer than four previous admissions 5. willing to accept long-acting injectable treatment and participate in rehabilitation exclusion criteria: 1. primary diagnosis other than schizophrenia 2. prior long acting injectable treatment 3. current suicide risk 4. hypersensitivity to aripiprazole 5. pregnancy 6. positive illicit drug screen other than cannabis (rescreening allowed in 4 weeks for drug positive cases) 7. unable to give personal informed consent 8. history of treatment resistance as evidenced by clozapine treatment 9. unable to stop treatment with medications that are strong cytochrome (cyp) 2d6 or cyp 3a4 inhibitors and or strong cyp3a4 inducers (2.3, 7.1) for at 14 days prior to initiation.

Keywords: relapse remission recovery
brain structural and functional connectivity changes in the period of dysmenorrhea: a prospective fmri study

Conditions: Dysmenorrhea

Summary: observational prospective study with an analysis of the changes in brain structure and related functional connectivity in women with dysmenorrhea.

dysmenorrhea is a common gynecological disease and chronic pain disorder.understanding the neural mechanisms of dysmenorrhea and the brain changes affecting pain factors is important for finding dysmenorrhea treatment methods. the emergence and progress of non-invasive neuroimaging technology can help us better understand pain at the neural level. recent developments in identifying brain-based biomarkers of pain through advances in advanced imaging can provide some foundations for predicting and detecting pain. twenty patients with dysmenorrhea and twenty matched female healthy controls were recruited from our hospital. all participants underwent the head magnetic resonance imaging scans to calculate grey matter volume and diffusion tensor imaging parameters. questionnaire assessment was also conducted.

Eligibility criteria:
inclusion criteria: * right-handedness, as confirmed by the edinburgh handedness inventory * a regular menstrual cycle of approximately 21 to 35 days * a history of menstrual pain longer than 6 months * not taking any medication or using other methods to treat dysmenorrhea in the past month * score of \>= 40mm on the vas (visual analogue scale) in recent three menstrual cycles exclusion criteria: * any psychiatric or neurological disorders, particularly premenstrual dysphoric disorder * using oral contraceptives, hormonal supplements, or any central-acting medication (eg, opioid, antiepileptics) within 6 months before the study * having a metal or pacemaker implant, claustrophobia, or any contraindications to mr * head injury with loss of consciousness

Keywords: dysmenorrhea, magnetic resonance imaging
prochlorperazine versus prochlorperazine & ketorolac in treatment of pediatric migraine in the emergency department

Conditions: Migraine

Summary: the aim of this study is to evaluate whether the use of prochlorperazine and ketorolac in combination lead in a larger reduction in pain score compared to prochlorperazine alone when treating pediatric migraine in the emergency department (ed). our hypothesis is that this combination of medications treats not only the pain but also the associated gastrointestinal symptoms of migraine. the main outcome of this study is the reduction in the patient's pain score at 60 minutes from administration of the study medications. secondary outcomes include the number of patients achieving complete resolution of the headache while in the ed, the number of patients requiring additional treatment interventions by the treating physician, the number of patients with resolution of the associated symptoms like nausea, vomiting, photophobia and phonophobia, the recurrence of headache in the 48-72 hours after discharge, and side effects of the medications.


Eligibility criteria:
inclusion criteria: 1. patient aged 8-18 years presenting to akron children's hospital (ach) ed with complaint of headache 2. patient has an established diagnosis of migraine without aura or as established by history meets the criteria for migraine headache as defined by the international criteria for headache disorder -ii in 2004 a. at least 5 episodes of headache b. the headache should last between 1-72 hours c. the headache should include two of the following: i. unilateral location, though may be bifrontal or frontotemporal in location but should not be occipital ii. pulsing quality iii. moderate to severe pain iv. aggravation by or causing avoidance of routine physical activity d. one of the following symptoms should accompany the headache i. nausea or vomiting ii. photophobia or phonophobia e. the headache should not be attributed to another disorder based on history, physical and/or laboratory information. exclusion criteria: 1. patients with a contraindication to receiving prochlorperazine, ketorolac, diphenhydramine, or naproxen 2. patients unable to complete the pain scale. 3. patients on medications that will have a drug-drug interaction with the study medication including prochlorperazine, ketorolac, diphenhydramine or naproxen. 4. patients with any medical condition that may be contributing or associated with the current headache such as concussion or trauma 5. female patients with a positive urine hcg point of care test 6. patients with diagnosis of or suspected to have chronic daily headaches defined as a headache lasting at least 4 hours for more than 15 days a month for the past 3 months. 7. patients who received prochlorperazine or ketorolac in the past 48 hours. 8. patients who had previously been randomized in this study in the past 3 months.

Keywords: migraine
study of cefditoren pivoxil in treatment of childhood with acute rhinosinusitis

Conditions: Rhinosinusitis

Summary: cefditoren pivoxil has been used in rhinosinusitis treatment. however, little is known about the efficacy of this drug at low and high doses.

the investigation was a randomized, investigator-blinded, and parallel study, conducted in patients (age 1-15 years) with acute rhinosinusitis. two groups of patients were randomized received low (10 mkd) or high (20 mkd) of drug for 14 days. changes in sinus symptoms scores, response rate and adverse effect were evaluated at days 7 and 14. relapse rate was recorded at days 21 and 28. recurrence of sinus symptoms at day 60 were assessed.

Eligibility criteria:
inclusion criteria: * children age 1-15 years old diagnosed acute rhinosinusitis exclusion criteria: * poor compliance * other infections

Keywords: rhinosinusitis cefditoren pivoxil
exercise-induced high-sensitivity troponin levels as a predictor for obstructive coronary artery disease

Conditions: Coronary Artery Disease

Summary: 1. to compare hs-tnt levels after a cardiac stress test in patients with vs. patients without cad 2. to assess the level of post-exercise hs-tnt predicting cad (using roc-analysis) 3. to determine the sensitivity, specificity and accuracy of this exercise-induced hstopt level in predicting cad, either alone or in relation to traditional patient-related and exercise test-related metrics


Eligibility criteria:
inclusion criteria: 1. patients with suspected cad, planned for diagnostic coronary angiogram 2. patients with previous revascularization, suspected of recurrent ischemia exclusion criteria: 1. congestive cardiomyopathy with lv ef \< 35% 2. renal failure with egfr \< 30 ml/min 3. known structural or severe valvular heart disease 4. prior cabg 5. previous acs \< 6 weeks 6. known incomplete revascularization after previous pci 7. unstable angina or acs (defined as unstable anginal symptoms + ecg changes or hs-tnt \> 0.053 ng/l)

Keywords: exercise test hs -troponin coronary artery disease