Kornimate/medical-research-clean huggingface dataset:
sputum induction by physiotherapy and hypertonic saline techniques in asthmatic children

Conditions: Asthma

Summary: this study evaluated whether physiotherapy is efficient in sputum induction and in evaluation of pulmonary inflammation in asthmatic children.

the hypertonic saline is a traditional technique to collect induced sputum, it´s safe and viable in asthmatic children, as well as the technique of sputum induction and processing has been standardized for schoolchildren. sometimes researchers have difficulties to obtain induced sputum in stable patients and it´s possible to use physiotherapy maneuvers to induced sputum. the manouvers are safe for adult and children asthmatics stable. this study aimed to evaluate the effectiveness to collect induced sputum by physiotherapy maneuvers.

Eligibility criteria:
inclusion criteria: * asthmathic children used inhaled corticosteroids not associated with long-acting beta2-agonist. exclusion criteria: * asthmathic children to diagnose with other chronic pulmonary pathologies (cystic fibrosis, ciliary dyskinesia, bronchiolitis obliterans, and bronchopulmonary dysplasia) before study, no significant pulmonary pathologies, incapacity to realize pulmonary function and insufficient sample.
quetiapine vs haloperidol decanoate for the long term treatment of schizophrenia and schizoaffective disorder

Conditions: Schizophrenia; Schizoaffective Disorder

Summary: the purpose of this research study is to determine whether a new drug for schizophrenia is better for the maintenance treatment than a standard drugs currently prescribed. the new medication is called quetiapine and it will be compared with a standard medication called haloperidol decanoate. the study will determine if quetiapine causes fewer problems than haloperidol with side effects such as stiffness and restlessness and whether it costs the va more or less to treat patients with quetiapine. in addition, blood samples will be collected every three months to determine if certain chemicals in the blood can influence the outcome of the subjects' illness.


Eligibility criteria:
inclusion criteria 1. schizophrenia or schizoaffective disorder diagnosed by dsm-iv 2. between the ages 18-60. 3. a candidate for maintenance antipsychotic therapy. this means that patients will have had at least two documented episodes of acute schizophrenic illness or at least two years of continuing psychotic symptoms. exclusion criteria 1. organic brain disease. 2. mental retardation 3. chronic medical illness which would make antipsychotic medication inappropriate.

Keywords: quetiapine haloperidol decanoate
periodontitis and vascular dysfunction

Conditions: Periodontitis; Intimal Medial Thickness of Internal Carotid Artery

Summary: the investigators wish to assess whether intensive periodontal therapy will reduce the burden of chronic periodontal disease and will cause regression or prevent progression of atherosclerosis assessed by a surrogate end-point (carotid intima-media thickness) at 24 months compared to control periodontal therapy.


Eligibility criteria:
inclusion criteria: 1. participants must be ≥ 18 years-old. 2. participants must have moderate to severe periodontitis (at least 30 periodontal pockets \> 4mm with bleeding on probing) and radiographic signs of bone loss. 3. participants must have voluntarily signed the informed consent. exclusion criteria: 1. female participant is pregnant or lactating or of childbearing and not using acceptable methods of birth control. 2. participant is on chronic treatment (i.e., two weeks or more) with specific medications known to affect periodontal status (phenytoin or cyclosporine) within one month of baseline visit. 3. participant knowingly has hiv or hepatitis. 4. participant has limited mental capacity or language skills such that simple instructions cannot be followed or information regarding adverse events cannot be provided. 5. participant on chronic antibiotic therapy or who require antibiotic coverage for periodontal procedures. 6. participant had a course of periodontal therapy in the preceding 6 month
randomized study comparing genz-644470, placebo, and sevelamer carbonate in chronic kidney disease patients on hemodialysis

Conditions: Kidney Failure, Chronic

Summary: the purpose of this clinical study is to compare the effects of genz-644470 with the effects of placebo and sevelamer carbonate (renvela®) on the reduction of serum phosphorus in hyperphosphatemic chronic kidney disease participants on hemodialysis.


Eligibility criteria:
inclusion criteria: * serum phosphate level greater than (\>) 5.5 milligram per deciliter (mg/dl) (1.78 millimole per liter \[mmol/l\]) after discontinuation of current phosphate binder therapy * men or women 18 years or older exclusion criteria: * have active dysphagia or swallowing disorder or a predisposition to or current bowel obstruction, ileus, or severe gastrointestinal motility disorders including severe constipation

Keywords: chronic kidney disease phosphate binder phosphate hyperphosphatemia
comparing effectiveness of the hydrus microstent (tm) to two istents to lower iop in phakic eyes

Conditions: Primary Open Angle Glaucoma; Pseudoexfoliative Glaucoma; Pigmentary Glaucoma

Summary: this clinical trial compares two implantable devices intended to lower the pressure inside the eye of glaucoma patients.

this is a prospective, multicenter, single-masked, randomized clinical trial comparing the hydrus microstent to two istent implants for the reduction of intraocular pressure in phakic patients with a positive diagnosis of primary open angle glaucoma, pseudoexfoliative glaucoma, or pigmentary dispersion glaucoma. post-operative follow-up visits will be conducted at regular intervals.

Eligibility criteria:
inclusion criteria: * a diagnosis of primary open angle glaucoma (poag), pseudoexfoliative (pxg) glaucoma, or pigmentary glaucoma (pg) * a phakic lens with bcva of 20/30 or better exclusion criteria: * forms of primary or secondary glaucoma not listed above * prior glaucoma surgery in the study eye

Keywords: primary open angle glaucoma poag pseudoexfoliative glaucoma pxg pigmentary glaucoma pg hydrus
azd6765 severe major depressive disorder (mdd) iv

Conditions: Major Depressive Disorder

Summary: the purpose of this research study is to determine whether azd6765 has an effect on the patient's depression when taken together with current depression medication. in addition, information will be gathered on how well azd6765 is tolerated, investigate the levels of azd6765 and the levels of the current depression medication in the blood. in addition, the research staff will determine if azd6765 has any mood or calming effects (how you feel).


Eligibility criteria:
inclusion criteria: * signed informed consent before any study-related procedures start. * the patient is previously diagnosed with major depressive disorder (mdd) and currently taking an antidepressant for at least 6 weeks. * patient has a history of poor response to 1 or more antidepressants (in addition to the antidepressant the patient is taking at enrollment) after exposure at adequate doses or maximum tolerated doses for ≥4 weeks. exclusion criteria: * patient has a lifetime history of schizophrenia, bipolar, psychosis or psychotic depression. * patient has a lifetime history of failure to ect therapy. * patient is pregnant or breast feeding. * length of current episode of depression exceeds ≥2 years.

Keywords: depression depressive disorder mdd
advanced understanding of staphylococcus aureus and pseudomonas aeruginosa infections in europe - icu

Conditions: Pneumonia; Pneumonia, Ventilator-Associated; Nosocomial Pneumonia

Summary: intensive care unit (icu) acquired pneumonia, including ventilator-associated pneumonia, is a frequently occurring health-care associated infection, which causes considerable morbidity, mortality and health care costs. important pathogens causing icu pneumonia are staphylococcus aureus and pseudomonas aeruginosa. the epidemiology of icu pneumonia and patient-related and contextual factors is not fully described, but is urgently needed to support the development of effective interventions.


Eligibility criteria:
inclusion criteria: 1. participant is 18 years or older at the time of enrollment. 2. participant is on mechanical ventilation at icu admission, or is (expected to be) within 24 hours thereafter, based on investigator's judgment. 3. expected stay in icu is 48 hours or longer based on investigator's judgment. 4. sa colonization status is known within 72 hours after start of first episode of mechanical ventilation and according to the result, the patient qualifies for enrollment. 5. written informed consent from subject / legally accepted representative within 72 hours after start of first episode of mechanical ventilation. exclusion criteria: 1. previous participation as a subject in the study cohort of this study. 2. simultaneous participation of the subject in any preventive experimental study into anti-staphylococcus or anti-pseudomonas aeruginosa interventions. 3. expected death (moribund status) within 48h, or icu discharge of the participant within 24h, at the moment of informed consent.

Keywords: s. aureus p. aeruginosa colonization pneumonia icu
stochastic resonance stimulation effect on gait stability in parkinson disease

Conditions: Parkinson Disease

Summary: the present study explored the use of a technique called stochastic resonance (sr) stimulation that may help individuals with parkinson disease maintain balance while walking on challenging surfaces. impaired balance represents one of the disease symptoms, putting people at risk for falls, partly due to impaired processing of sensory information. sr uses light electrical signals to improve the way the body detects sensations. we wanted to test if sr could help people with parkinson disease stay steadier while walking. each participant's optimal sr intensity was determined before they walked on a treadmill in a virtual environment that created visual disturbances to challenge their balance. we measured how much their body swayed, how they placed their feet, and how their ankles moved during the walking tasks.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of parkinson disease * hoehn and yahr (h\&y) stage ≤ iii * can walk independently for at least 2 minutes without an assistive device or orthosis * ability to communicate discomfort during testing * can follow multi-step commands * scored at least 24/30 on the montreal cognitive assessment (moca) exclusion criteria: * any head, neck, or face injury in the six months prior to the study (e.g., concussion, eye injury) * history of vestibular or ocular dysfunction * currently taking any medications affecting balance (i.e. antibiotics) * injuries to lower extremities affecting balance in the past six months * pregnancy * any neurological disorders other than parkinson's disease (e.g., seizure disorders, closed head injuries with loss of consciousness greater than 15 minutes, cns neoplasm, history of stroke) * unstable cardiac or pulmonary disease * clinically obese (bmi 30 or above) * any metal implant in the feet or legs that is close to the stimulating electrodes * a known allergy to medical-grade adhesives * any other comorbidity affecting the ability to safely walk without assistance for at least 2 minutes * exhibited severe dyskinesia * did not respond to l-dopa or other dopaminergic treatment * exhibited cardiovascular-autonomic or multiple-system symptoms indicative of a "parkinsonism-plus" presentation
age influence on cortical bone measured by ultrasound

Conditions: Cortical Bone Erosion

Summary: the study of this study is to evaluate the age influence on cortical bone strength properties by two methods:hr-pqct (highresolution-peripheral quantitativecomputedtomography) and ultrasound. the main objective consists in the evaluation of the age influence on cortical thickness at 1/3 distal radius measured by us.

the study of this study is to evaluate the age influence on cortical bone by two methods: hr-pqct and ultrasound. 84 patients will be measured. the cohort will be: * 21 women less than 70 * 21 women more than 70 * 21 men less than 70 * 21 men more than 70 measurement will be performed at radius and at tibia (ultra-distal and distal). for all the sites one measurement will be performed by hr-pqct to get reference values of thickness and bmds. for the distal positions and additional measurement will be performed by an innovative ultrasound device that estimates cortical thickness and porosity. the participation to the study implies only a participation of one hour from the patient (30min for hr-pqct measurements, 30 min for us). the main objectives consist in : * evaluating the age influence on cortical thickness at 1/3 distal radius measured by us * evaluating the age influence on cortical thickness at distal tibia measured by us * comparing porosities values measured by us to vbmd obtained by hr-pqct * comparing cortical thickness values measured by hr-pqct at 1/3 distal radius position to ultra-distal radus position and to the tibia * comparing vbmd values measured by hrpqct at 1/3 distal radius position to ultra-distal radius position and to the tibia

Eligibility criteria:
inclusion criteria: * being 18 or older * coming from the rheumatology consultation at lariboisière hospital exclusion criteria: * bmi \> 28 * bmi \< 15 * cortisone treatment * recent fracture at non-dominant arm * wound on measuring zone * treatment interfering with bone architecture or bone density : oral of transdermic oestrogenes, bisphosphonates (alendronate, risedronate, zoledronate) or denosumab during the past 6 months-

Keywords: osteoporosis
mechanism underlying beta-cell failure in obese african americans with history of hyperglycemic crises

Conditions: Diabetes Mellitus, Type 2

Summary: obesity is common in african american (aa) patients with newly diagnosed diabetes who present with diabetic ketoacidosis (dka). despite the presentation with severe symptoms of insulinopenia and ketoacidosis, clinical and immunogenetic observations indicate that most obese aa patients with dka have type 2 diabetes. in such patients, previous studies reveal that: a) at presentation, obese aa patients with dka have markedly decreased pancreatic insulin secretion, lower than in obese non-dka patients admitted with comparable hyperglycemia, but significantly greater than in lean patients with dka; b) aggressive diabetic management results in significant improvement in beta-cell function and insulin sensitivity sufficient to allow discontinuation of insulin therapy within 3 months of follow-up. based on these observations the researchers conclude that similar to obese patients with hyperglycemia, most obese aa with dka have type 2 diabetes, and that although defects in both insulin secretion and insulin action are present, transient b-cell failure is the primary defect in the development of ketoacidosis.

obese aa patients with a history of dka who later experience near-normoglycemia remission represent an ideal population in which to define the sequence of events that lead to b-cell dysfunction in type 2 diabetes. the researchers hypothesize that obese aa with dka will prove particularly susceptible to beta-cells dysfunction due to sustained elevations of plasma glucose (glucose toxicity) and/or free fatty acid levels (lipotoxicity). this study will test beta-cell response by administering a glucose infusion to diabetic african americans with a history of dka, diabetic african americans without a history of dka, and non-diabetic african americans.

Eligibility criteria:
inclusion criteria: * obese african american subjects (body mass index (bmi) equal or greater than 30) * age 18-65 * patients with a history of diabetic ketoacidosis as defined by the american diabetes association (ada) criteria * patients admitted with hyperglycemia but without ketoacidosis (blood glucose greater than 400ml/dl without evidence of ketosis/ketones * obese nondiabetic controls (bmi \>30; ruled out for diabetes with a 75g oral glucose tolerance test) exclusion criteria: * patients with positive autoimmune markers (islet cell or glutamic acid decarboxylase (gad) autoantibodies) * patients with significant medical or surgical illness, including but not limited to myocardial ischemia, congestive heart failure, chronic renal insufficiency, liver failure, and infectious processes * patients with recognized or suspected endocrine disorders associated with increased insulin resistance, such as hypercortisolism, acromegaly, or hyperthyroidism * patients with bleeding disorders, thrombocytopenia, or abnormalities in coagulation studies * patients with fasting hyperglycemia (blood glucose \> 120 mg/dl) after discontinuation of insulin therapy * pregnancy

Keywords: hyperglycemia
evolution of cellular and viral resistance in hiv-infected patients with lymphoma

Conditions: HIV; Lymphoma

Summary: the study's chief objective is to observe the evolution of cellular (in terms of expression of transmembrane transporters and their transcriptional regulators) and viral resistance (in terms of development of mutations in the hiv genome that may confer resistance to future treatment for hiv) in hiv-infected patients with lymphoma.

the study team will take two or three tubes of blood on three occasions during the course of chemotherapy. the total amount of blood required for this research project is 64ml (approximately 4 tablespoons). this will allow better understanding of the changes that take place in the blood and the hiv virus itself. it is hoped that this will provide new insights that may aid the understanding and treatment of hiv patients with lymphoma.

Eligibility criteria:
inclusion criteria: * the ability to understand and sign a written informed consent form, prior to participation in any screening procedure and must be willing to comply with all study requirements. * documented hiv-1 infection. * diagnosis of lymphoma (with the exclusion of the five subjects that will be controls). * on cart or about to start cart as part of clinical routine care before the initiation of chemotherapy. exclusion criteria: - receiving anti-tuberculosis treatment.
mean systemic filling pressure and heart performance predicting fluid responsiveness

Conditions: Cardiac Output, High

Summary: determining fluid responsiveness in critically ill patients by measuring mean systemic filling pressure on the intensive care unit.

the assessment of the cardiovascular state in critically ill patients is subject to difficulties in terms of the fact that several hemodynamic parameters, for example mean arterial blood pressure (map) and cardiac output (co) supply insufficient information about the circulating volume and cardiac performance. there is a clinical need to adequate determination of intravascular volume status and therefore reliable predictors of fluid responsiveness are highly relevant. however, in determining the fluid status of a patient, the lack of appreciation of the venous side of the circulation persists today, which is greatly due to the inability to appropriately assess the venous side of the circulation. the importance of the venous part of the circulation is moreover reflected by the fact that an increase in venous resistance does reduce co many times more than a similar increase in arterial resistance. mean systemic filling pressure (pms), which is defined as the pressure equal to the pressure which would be measured if the heart should suddenly stop pumping and all (arterial and venous) the pressures in the entire circulatory system should be brought to equilibrium instantaneously, is a good, complete and reliable reflection of the total intravascular fluid compartment. passive leg raising (plr) represents a "self-volume challenge" that predicts preload responsiveness and the transient hemodynamic changes on venous return can be directly monitored in ventilated patients, provided that there is an intact circulation, in order to test the amount of volume responsiveness.

Eligibility criteria:
inclusion criteria: * patients must be older than 18 years, and must be equipped with a pulse-contour cardiac output system with a central venous catheter. patients will be subsequently connected to the hemodynamic monitoring device navigator™. in those patients with clinical signs of inadequate tissue perfusion, passive leg raising and standardized fluid challenge will be performed. exclusion criteria: * patients with assist devices (e.g. intra aortic balloon pump, impella®, ecmo), patients with arrhythmias (either atrial of ventricular) will be excluded from the study. also, patients with inguinal impairment or contraindications for a passive leg raising will be excluded (such as deep venous thrombosis or elastic compression stocking), head trauma, an increase intra-abdominal pressure suspected by clinical context and examination as well as patients with absolute contraindications for fluid challenge.

Keywords: volume responsiveness mean systemic filling pressure
acute effect of blood flow restricted high-intensity resistive training

Conditions: High-Intensity Interval Training; Blood Flow Restriction Exercise

Summary: recommended by many professional organizations such as the american college of sports medicine (acsm) and the national strength and conditioning association (nsca), resistance exercise training improves muscle strength, body composition, performance, functionality and quality of life in healthy young adults. blood flow restriction (bfr), also known as kaatsu training, is proposed as a new method to improve muscle strength and muscle hypertrophy in a short time. although there are studies in the literature in which bfr is applied with low-intensity resistance training, no studies have been found examining the effects of bfr applied with high-intensity resistance training on the neuromuscular adaptations of the quadriceps femoris muscle. determining whether high-intensity resistance training with bfr is more effective on the quadriceps femoris muscle compared to high-intensity resistance training applied without bfr may provide faster and more effective responses by arranging resistance training protocols in terms of neuromuscular gains. between 07.03.2022 and 07.06.2022, in the biruni university physiotherapy and rehabilitation department application laboratory, in which 24 healthy young adults between the ages of 18-25 (from 12 bfr, 12 bfr) will be included, exercise training to be applied with and without bfr was determined. its effects will be compared with electromyographic measurement, single leg squat test, and measurement of late-onset muscle pain (visual analog scale). ibm spss 21.0 statistical program will be used for statistical analysis. whether the variables are suitable for normal distribution will be analyzed with the shapiro-wilk test. if the variables show normal distribution, the variation within the group will be analyzed with the paired samples t test, and if it does not show normal distribution, the wilcoxon signed rank test will be analyzed. comparison of groups will be made with independent samples t-test in independent groups if the variables show normal distribution, and with mann whitney-u test if they do not show normal distribution. categorical data distributions will be evaluated with the chi-square test.


Eligibility criteria:
inclusion criteria: * between the ages of 18-25 * healthy * be volunteer to participate the study exclusion criteria: * pregnancy * breastfeeding status * cardiovascular disease * musculoskeletal problems * orthopedic problems related to the lower extremities * peripheral or central neurological disorders