Kornimate/medical-research-clean huggingface dataset:
medication development in alcoholism: apremilast versus placebo

Conditions: Alcohol Use Disorder

Summary: the primary hypotheses under test are that alcohol dependent subjects treated with apremilast will report decreased craving for alcohol following alcohol exposure in the laboratory and report significantly less drinking under naturalistic conditions, than those treated with placebo.


Eligibility criteria:
inclusion criteria: * male or female volunteers, 18-65 years of age * meets dsm-5 criteria for current alcohol use disorder of moderate or greater severity (aud-ms) * in the month prior to screening, reports drinking ≥ 21 standard drinks per week if male, ≥ 14 if female, with at least one heavy drinking day (≥ 5 males, ≥ 4 females) per week. * subjects will not be seeking treatment because the medication studies are not treatment trials, and to avoid exposing treatment-seekers to alcohol cues * subjects must be abstinent a minimum of 3 days (but not more than 7 days) prior to the human lab session * negative bac and a ciwa score of \< 9 at time of lab session to eliminate acute alcohol or withdrawal effects on dependent measures. * in acceptable health in the judgment of the study physician, on the basis of interview, medical history, physical exam, ekg, routine urine and blood chemistry. * females with childbearing potential must have a negative pregnancy test on the screening, randomization, and lab session visits and agree to use effective birth control for the duration required by a given study. * able to provide informed consent and understand questionnaires and study procedure * willing to comply with the provisions of the protocol and take daily oral medication. exclusion criteria: * active suicidal ideation, as systematically assessed with the columbia suicide severity rating scale. * meets dsm-5 criteria for a major psychiatric disorder, including mood or anxiety disorders or substance use disorders other than alcohol or nicotine * has a urine drug screen (uds) positive for substances of abuse other than alcohol. * significant medical disorders that will increase potential risk or interfere with study participation as determined by the study physician * known hypersensitivity to apremilast * treatment within the month prior to screening with (1) an investigational drug, (2) medications which may negatively interact with study medications, or (3) drugs that may influence study outcomes (e.g., disulfiram \[antabuse\], naltrexone \[revia\], acamprosate \[campral\], anticonvulsants, or antidepressants). * ongoing treatment with medications that may increase risk, including prescribed, over-the-counter, and herbal preparations, as determined by the study physician. * sexually active female subjects with childbearing potential who are pregnant, nursing, or refuse to use effective methods of birth control for the duration required by a specific protocol. * no fixed domicile and/or no availability by home or mobile telephone * history of hypersensitivity to the study drug or the ingredients. * failure to take double-blind medication as prescribed.
selective early medical treatment of patent ductus arteriosus in extremely low gestational age infants: a pilot rct

Conditions: Patent Ductus Arteriosus After Premature Birth

Summary: background: among preterm infants, those born at a gestational age less than 26 weeks are considered the most vulnerable with a high risk of short- and long-term health problems that include chronic lung disease, brain bleeds, gut injury, kidney failure and death. patent ductus arteriosus (pda) is the most common heart condition with almost 70% preterm infants in this gestational age group being diagnosed with a pda. though many pdas spontaneously resolve on their own, research suggests that if the pda persists, it may contribute to a number of these short- and long-term health problems. non-steroidal anti-inflammatory medications such as ibuprofen are commonly used to treat a pda. such drugs can also have harmful effects on the gut and kidneys of extremely preterm infants. therefore, we are unsure if early treatment of a symptomatic pda in this age group is at all beneficial. given the wide variation in pda treatment approaches in this age group, a randomized trial design, where extremely preterm infants with a symptomatic pda are randomly assigned to early treatment or no early treatment, is essential to address this question. purpose of the study: the overall purpose of this pilot study is to assess the feasibility of conducting a large study to explore the following research question: in preterm infants born \<26 weeks' gestation, is a strategy of selective early medical treatment of a symptomatic pda better than no treatment at all in the first week of life? the main feasibility objectives of this study are: 1. to assess how many eligible infants can be enrolled in the study 2. to assess how many enrolled infants properly complete the study protocol importance: to our knowledge this will be the first study on pda management in preterm infants that specifically aims to enroll preterm infants born at \<26 weeks of gestational age who are at the highest risk for pda-related problems but have been mostly under-represented in previous pda studies.


Eligibility criteria:
inclusion criteria: * preterm infants less than 26 completed weeks (i.e., up to and including 25 weeks and 6 days) of gestation exclusion criteria: * no pda on initial screening echocardiography * congenital heart disease (excluding patent foramen ovale, atrial septal defect or ventricular septal defect with a defect size less than 2mm) * other major congenital anomaly * decision to withhold/withdraw care

Keywords: extremely preterm infant early medical treatment randomized controlled trial
targeted ballet class for cerebral palsy

Conditions: Cerebral Palsy

Summary: this study aims to investigate the effect of the targeted ballet dance on participants with cerebral palsy

cerebral palsy (cp) is the most common motor disorder in childhood, with a prevalence of 3.1 to 3.6 cases per 1000 living births in the united states. the motor signs of cp include abnormal muscle tone and motor control, preventing individuals with cp from participating in normal daily activity. the most common type of cp is spastic cp, in which spasticity is present and range of motion in the joints is reduced. physical therapy is one fundamental method of rehabilitation that attempts to recover motor function via exercises, while the effects of physical therapy are still elusive due to the lack of comprehensive evidence. this study uses a targeted ballet class to promote balance, increased range of motion, and reduced spasticity. the combination of qualitative clinical measures and quantitative assessment spasticity aims to demonstrate the benefits brought by the dance class.

Eligibility criteria:
inclusion criteria: * diagnosed with spastic cerebral palsy * is between 3 to 64 years old * have no uncorrected vision * have no other neuromuscular or musculoskeletal condition * have not had surgical procedures within six months of enrollment in the study * participate in stable school and/or private physical therapy with a frequency no greater than one session per week * have no changes in medication for the last six months * have the ability to pay attention and follow three-step directions * be medically stable, (8) have no other concurrent illness * have not received any botox treatment within three months previous to the initiation of the study, and have gross motor system classification scale (gmfcs) i-iv (not v). exclusion criteria: * not meeting all of the criteria
10-year retrospective study of oral and maxillofacial squamous cell carcinoma

Conditions: HNSCC; AI; Radiomic; MRI

Summary: introduction: the incidence of occult cervical lymph node metastases (oclnm) is reported to be 20%-30% in early-stage oral cancer and oropharyngeal cancer. there is a lack of an accurate diagnostic method to predict occult lymph node metastasis and to help surgeons make precise treatment decisions. aim: to construct and evaluate a preoperative diagnostic method to predict occult lymph node metastasis (oclnm) in early-stage oral and oropharyngeal squamous cell carcinoma (oc and op scc) based on deep learning features (dlfs) and radiomics features. methods: a total of 319 patients diagnosed with early-stage oc or op scc were retrospectively enrolled and divided into training, test and external validation sets. traditional radiomics features and dlfs were extracted from their mri images. the least absolute shrinkage and selection operator (lasso) analysis was employed to identify the most valuable features. prediction models for oclnm were developed using radiomics features and dlfs. the effectiveness of the models and their clinical applicability were evaluated using the area under the curve (auc), decision curve analysis (dca) and survival analysis.


Eligibility criteria:
inclusion criteria: 1. pathologically confirmed, previously untreated oral and oropharyngeal squamous cell carcinoma with radical resection; 2. mri examination was performed two weeks before surgery; 3. all patients with neck dissection and the status of regional lymph nodes was confirmed via pathological examination; 4. all patients had no clinical evidence of nodal involvement. exclusion criteria: 1. other malignant tumor, such as adenoid cystic carcinoma; 2. a lack of complete mri imaging or poor mri imaging quality; 3. patients had undergone neck dissection or treated non-surgically; 4. patients with metastatic disease.
react - real care for asthma - a disease study to identify patients with severe uncontrolled asthma

Conditions: Asthma, Bronchial

Summary: this is a multi-center, single-country, single-arm, prospective, disease study to collect real world data of patients with severe uncontrolled asthma in germany.

this observational disease study aims to improve the understanding of the real-world situation of patients with severe uncontrolled asthma, the influence of environmental factors on the risk of exacerbations as well as the patients' quality of life. the patients will provide self-reported information about their asthma control and medication use in a 12 months period after study enrollment. additional patient information will be collected from existing electronical records (emrs). furthermore, patient- and provider-reported attitude towards healthcare and monitoring (measured through patient- and provider-reported experience measurements \[prems\]) will be collected to measure the level of satisfaction with the healthcare provision, digital and analog healthcare support programs, and the preferences in monitoring tools. the information will be collected either digitally with an application or analogically with paper-based questionnaires.

Eligibility criteria:
inclusion criteria: * ≥18 years of age at the time of consent * therapy within gina/nvl steps 4 or 5 and uncontrolled disease in the previous 12 months as per the healthcare provider's assessment * willing and able to provide written informed consent indicating that they understand the purpose and procedures required for the study and are willing to participate * able to read, understand, and speak german sufficiently to complete all the questionnaires exclusion criteria: * according to the assessment of the study physician: cognitive impairment, psychiatric diseases, severe hearing or vision impairment, insufficient knowledge of the german language, if these factors could influence the ability to provide written consent and correct completion and assessment of the questionnaires. * current participation in an observational study that might, in the investigator's opinion, influence the assessment for the current study, or participation in a randomized clinical trial in the last 30 days.

Keywords: severe asthma real-world evidence quality of life
clinical trial on frozen shoulder using bilateral shoulder radiography in different position

Conditions: Frozen Shoulder

Summary: this study on frozen shoulder addressed the null hypothesis that there is no difference in the motion of scapula against the thoracic wall between affected and non-affected shoulder.

adult patients with unilateral shoulder pain lasted for more than one month, accompanied by passive and active limitation of range of motion in all directions will be included. patients with bilateral involvement, history of trauma, history of surgery on the affected shoulder, history of fracture, shoulder osteoarthritis, symptoms less than one month and any signs of rotator cuff tear will be excluded. mr imaging will be done to exclude other pathologies and frank rotator cuff tear.

Eligibility criteria:
inclusion criteria: * adult patients with unilateral shoulder pain lasted for more than one month, accompanied by passive and active limitation of range of motion in all directions exclusion criteria: * bilateral involvement, history of trauma, history of surgery on the affected shoulder, history of fracture, shoulder osteoarthritis, symptoms less than one month and any signs of rotator cuff tear. mri will be done to rull out the rotator cuff tear.

Keywords: frozen shoulder scapulothoracic angle scapulohumeral angle acromiohumeral distance center equator distance shoulder radiography
a new cardiac rehabilitation treatment in the application of ischemic heart disease

Conditions: Ischemic Heart Disease; Cardiac Rehabilitation

Summary: cardiac rehabilitation is an important link in cardiovascular disease. this study mainly explores the effectiveness of new cardiac rehabilitation therapy (early respiratory rehabilitation, phase i rehabilitation, exercise therapy, external counterpulsation, extracorporeal shock wave, etc.) on patients with ischemic heart disease such as coronary heart disease and heart failure, and the compliance of home rehabilitation compared with traditional cardiac rehabilitation therapy (traditional exercise rehabilitation, rehabilitation education, etc.).

this study is a prospective, randomized, controlled study, follow the principle of picost design, specific as follows: participants (the list) : preliminary clinical diagnosis of coronary atherosclerotic heart disease, heart failure. intervention (intervention) : conventional drug therapy + new cardiac rehabilitation therapy, a new cardiac rehabilitation treatment reference guide requirements, according to the actual circumstance of patients treated with 1-3 months intervention. comparator(control): conventional drug therapy + traditional cardiac rehabilitation therapy. the traditional cardiac rehabilitation therapy referred to domestic and international guidelines and consensus, and used 1 week-3 months of treatment intervention according to the actual situation of patients. outcome (the end) : the primary end point: d_spect examination, were followed up for 6 months to evaluate myocardial perfusion imaging is reduce ischemic area. the secondary end point: 1) the blood biochemical examination and myocardial necrosis markers, etc.; 2) the cardiopulmonary exercise testing: maximum kilograms oxygen uptake and anaerobic threshold when the maximum kilograms oxygen uptake; 3) the major adverse cardiovascular events: cardioascular death, non-fatal myocardial infarction, unplanned coronary artery reconstruction, stroke, heart failure and angina associated hospitalized again; 4) patients family rehabilitation treatment adherence

Eligibility criteria:
inclusion criteria: * aged between 18 and 85 years old * female subjects no pregnancy * the main admission diagnosis of ischemic heart disease (coronary heart disease, myocardial infarction, ischemic heart failure, etc.) * the need for cardiac rehabilitation treatment exclusion criteria: * acute respiratory distress syndrome (ards); * acute episode of copd; * uncontrolled pulmonary infection; * acute heart failure; acute pulmonary embolism; * acute myocarditis/pericarditis; * severe arrhythmia (degree ii or iii atrioventricular block, atrial flutter, or atrial fibrillation); * sternotomy, rib fracture, thoracic deformity, or other neurological diseases that may affect respiratory muscles

Keywords: coronary atherosclerotic cardiopathy cardiac shock wave therapy exercise rehabilitation cardiac rehabilitation ischemic heart disease
living well with stroke

Conditions: Cerebrovascular Stroke; Depression

Summary: the overall goal of this study is to conduct a three-armed randomized controlled trial (rct) in stroke survivors with depression to determine if a brief psychosocial-behavioral therapy intervention delivered in-person (arm a) or by telephone (arm b) is better than usual care (arm c), in terms of percent reduction in depressive symptoms and % of participants achieving remission of symptoms.

this is the second phase of a study whose aim was to evaluate the short and long-term efficacy of a brief psychosocial/behavioral intervention (with adjunctive antidepressant)for the treatment of post-stroke depression (psd) in survivors of ischemic stroke (registered as clinical trail nct00194454). in the earlier trial we demonstrated that a pleasant event/problem-solving brief psychosocial-behavioral therapy delivered by psychosocial nurse practitioners was highly effective in treating major depression and promoting remission in ischemic stroke survivors for up to two years. in this phase, we refine the protocol, and potentially make it more cost effective, by conducting a randomized comparative effectiveness trial of in-person versus telephone delivery of the intervention, comparing with usual care control. we also seek to expand our sample to include hemorrhagic stroke survivors (intraparenchymal hemorrhage and subarachnoid hemorrhage) as well as those with ischemic stroke.

Eligibility criteria:
inclusion criteria: * hospitalized for an ischemic or hemorrhagic stroke (intraparenchymal hemorrhage- iph or subarachnoid hemorrhage - sah) in the past 3 months * clinical depression symptoms (geriatric depression score -gds \>= 11 exclusion criteria: * major psychiatric co-morbidity * active suicidal ideation without ability to contract for safety * current substance abuse * physical inability to tolerate 1-2 hour sessions * receptive or global aphasia * reduced level of consciousness (gcs\<15).

Keywords: stroke recovery quality of life
the adrb3 receptor in pregnancy

Conditions: Pregnancy Complications

Summary: the primary overall objective of this study is to characterize the levels of and compare levels of the adrb3 receptor in human non-pregnant myometrium, pregnant myometrium at different time points in pregnancy, in normal and dysfunctional labor and also to measure levels and expression of these receptors in placental arteries at different maturation statuses of placenta and in pre-eclampsia/hypertension


Eligibility criteria:
inclusion criteria: * women undergoing cesarian section exclusion criteria: * interkurrent diseases

Keywords: arterial contractility uterine contractility
computer aided evaluation of orbital volume

Conditions: Orbital Fractures

Summary: a retrospective review to assess the performance and clinical predictive value of a novel software program (maxillo) designed to perform complex volumetric analysis with application in the field of orbital trauma.

the concept of open reduction and internal fixation of large and complex traumatic orbital deformities is well established. it is known that successful orbital reconstruction hinges upon restoration of native orbital volume in order to establish pre-morbid function and avoid long-term complications. to date, a facile, reliable, and reproducible method to measure orbital volume has not been rendered, despite numerous approaches. the objective of this study is to assess the performance and clinical predictive value of a novel software program designed to perform complex volumetric analysis with application in the field of orbital trauma.

Eligibility criteria:
inclusion criteria: * chart reviews of patients at ucdmc with orbital trauma and having operative repair of the orbital fractures with post-reduction imaging included. exclusion criteria: * absences of post-operative imaging

Keywords: orbital fractures
medium-dose uva1 versus narrow-band uvb in atopic dermatitis

Conditions: Atopic Dermatitis

Summary: atopic dermatitis (ad) is a very common disorder that is characterized by pruritic inflammatory skin lesions, with patients usually having an individual or family history of atopic diseases in their background. phototherapy is among the first-line approaches in the management of ad. in this context, a variety of studies have shown a beneficial effect of natural or artificial uv radiation in atopic dermatitis (ad). the past ten years have seen the introduction of new phototherapeutic regimens for ad, including uva1 and nb-uvb.uva1 seems to be more effective than the above mentioned broadband spectra, in particular in acute severe ad. the aim of the present study is the comparison of uva1 and nb-uvb phototherapy in the treatment of ad. additionally, the course of several cytokines, human beta-defensins, and smad-proteins will be evaluated during the course of treatment.

atopic dermatitis (ad) is a very common disorder that is characterized by pruritic inflammatory skin lesions, with patients usually having an individual or family history of atopic diseases in their background (e.g., allergic asthma and rhinitis). defective skin barrier, immunological dysfunctions (type i and iv allergy), genetic disorders, and psychological factors contribute to the pathogenesis of ad. however, among these factors, cd4+ th cells are reported to play a particularly crucial role in the pathogenesis of ad. phototherapy is among the first-line approaches in the management of ad. in this context, a variety of studies have shown a beneficial effect of natural or artificial uv radiation in atopic dermatitis (ad). different broadband uv spectra (bb-uva, bb-uvb, bb-uva/bb-uvb) and combined treatment modalities such as balneophototherapy and puva have previously been proven to be effective in ad. however the past ten years have seen the introduction of new phototherapeutic regimens for ad, including uva1 and nb-uvb.uva1 seems to be more effective than the above mentioned broadband spectra, in particular in acute severe ad. the aim of the present study is the comparison of uva1 and nb-uvb phototherapy in the treatment of ad. additionally, the course of several cytokines, human beta-defensins, and smad-proteins will be evaluated during the course of treatment.

Eligibility criteria:
inclusion criteria: * patients with chronic ad (hanifin and rajka, 1980); moderate to severe disease with scorad-index \> 30 (maximum = 102). * age \> 18 years * no topical steroids (except 1% hydrocortisone) or topical/systemic antibiotics or antihistamines within the last 2 weeks, no systemic glucocorticosteroids or other immunosuppressive agents within the last 8 weeks, no phototherapy within the last 12 weeks before inclusion exclusion criteria: * pregnancy or lactation * skin cancer or dysplastic naevi, photosensitive skin diseases, autoimmune diseases or relevant cardiovascular diseases * photo-skin type i according to fitzpatrick

Keywords: uva1 n-b uvb phototherapy atopic dermatitis scorad index