Kornimate/medical-research-clean huggingface dataset:
thermal micro-cautery for painful knee osteoarthritis

Conditions: Chronic Pain Syndrome

Summary: to trial a traditional pain management technique from ayurveda in a modern way - the technique involves micro - cautery to painful areas in knee osteoarthritis for patients on a waiting list for knee replacement. the investigators will include a waiting list control series.

the research and ethics committee at tallaght university hospital approved the recruitment of patient into the study by invitation. patients who accepted the invitation were enrolled into the intervention group and patients who declined the invitation were enrolled into the control group and both groups were followed up for 8 week period. agnikarma is a traditional surgical technique (thermal cautery) described in ancient surgical manuscripts for the treatment of severe persistent pain. it applies intense heat to points of maximum pain agreed with the patient pre procedure. the heat is applied by a metal rod (shalaka) heated in an open naked flame. the rod is applied to the skin at the agreed pain point in an even manner and generates a micro second degree burn. a traditional herbal cream is then applied which cools the application as reported by the patient. it is usual to allow skin healing to occur before the application of further heat (1-2 weeks). the pain points can move within a painful area and the technique best works with precise application to the current pain point. so before each application the precise points are agreed with the patient in advance by demarcating the painful area with a pen and searching for the points of maximum tenderness within that field. the purpose of this study was simply to define if indeed this technique delivers pain relief as observed in practice. the investigators chose one group to study - painful knee arthritis. in this condition patients often wait many years for the definitive procedure and run some risks with current pain relief treatment. as these patients were not the normal attendees at a pain clinic the investigators decided in advance to limit the study to 4 applications over a 4- 8 week period, the latter to allow for different speeds at which the skin might heal. the investigators recruited both our interventional group and waiting list control group from the same orthopedic waiting list.

Eligibility criteria:
inclusion criteria: * awaiting knee replacement surgery on an orthopaedic waiting list exclusion criteria: * none
data collection of patients treated with the colonring™ for the creation of circular compression anastomosis

Conditions: Diverticulum, Colon; Colorectal Neoplasms; Crohn Disease; Colitis, Ulcerative; Colostomy; Ileostomy - Stoma; Rectal Prolapse; Intestinal Polyposis; Lymphoma; Endometriosis; Intestinal Volvulus

Summary: the proposed study is a post marketing, observational, retrospective data collection intended to gather and record data on patients treated with the colonring™ device in routine clinical practice at a single center. the data will assist in further evaluating the performance of the colonring™ device in regards to the creation of a colorectal anastomosis. hypothesis:the performance of the colonring™, determined by the rate of complications, will be within the acceptable range reported in the literature for alternative treatment modalities.


Eligibility criteria:
inclusion criteria: * patient was \> 18 years old at time of procedure * patient underwent an open or laparoscopic colorectal procedure with the creation of an anastomosis using the colonring™ * patient treated in routine clinical practice following marketing clearance of the device within the cleared intended use * patient underwent his/her first follow-up visit within two months post-surgery exclusion criteria: * no exclusion criteria have been defined for this data collection.

Keywords: compression anastomosis
a study in male and female subjects with androgenetic alopecia treated with ati-50002 topical solution

Conditions: Androgenetic Alopecia

Summary: open label study to assess safety, tolerability, and efficacy of ati-50002 in male and female subjects with androgenetic alopecia.

this is an open-label study designed to evaluate the safety and efficacy of ati-50002 topical solution in male and female subjects with androgenetic alopecia.

Eligibility criteria:
inclusion criteria: male subjects and non-pregnant, non-nursing female subjects 18-50 years of age with a clinical diagnosis of androgenetic alopecia. subjects willing to agree to have a small circle of hair clipped to approx. 1mm in length on their balding spot. subjects willing to agree to have a permanent dot tattoo applied to their scalp to mark the center of the identified target area. subjects must agree to maintain the same hair style and hair care regimen during the study. exclusion criteria: females who are nursing, pregnant, or planning to become pregnant for the duration of the study and up to 30 days after the last application of study medication. clinical diagnosis of alopecia areata or other non aga forms of alopecia. scalp hair loss on the treatment area, due to disease, injury or medical therapy. active skin disease of the scalp (such as psoriasis or seborrheic dermatitis) or a history of skin disease on the scalp that in the opinion of the investigator would interfere with the study assessments or efficacy or safety.
does cervical mobilization have an effect on hand function in patients with double crush syndrome?

Conditions: Double Crush Syndrome

Summary: all double crush syndrome patients were assessed via vas, bctq \& nerve conduction study before and after the treatment program.

the patients were classified randomly into two groups, the control group received a standard physical therapy program of nerve glide, hand strengthening exercise and mobilization and the study group they received a cervical mobilization in addition to the standard physical therapy program for 12 sessions.

Eligibility criteria:
inclusion criteria: * thirty female patients diagnosed as double crush syndrome based on the clinical diagnostic criteria of the american academy of neurology, (american academy of neurology 2019). * patient ages ranged from 25 to 35 years old. patient who reported pain, hyperesthesia, and/or paresthesia at the course of median nerve distribution and upper limb. * a nerve conduction study (ncs) evidence of peripheral entrapment of median nerve at level of carpal bone "carpal tunnel syndrome" with a fractionated sensory nerve conduction velocity for the median nerve across the wrist of 40 m/s or less and with sensory peak latency \> 3.6 ms and recordable and with motor distal latency \>4.4 ms and less than 6.5ms. exclusion criteria: * patients had systemic disease causes double crush syndrome as rheumatoid arthritis (ra), thyroid disease, diabetes mellitus (dm), pregnant women, patients with concomitant neurological disease as peripheral neuropathy, patients with history of wrist surgery, fracture, or carpal tunnel injection in the last two weeks before the study, patients who have wasting of the thenar muscles, patients with previous surgery for cts. * patients with complete conduction block on edx or previous regular exposure to hand-held vibrating tools, patients with nerve conduction study with motor distal latency \> 6.5 ms.

Keywords: cervical mobilization hand function double crush syndrome
evaluate the efficacy and safety of one course of amevive in taiwan patients

Conditions: Chronic Plaque Psoriasis

Summary: an open-label, multicentre study to evaluate the efficacy and safety of one course of weekly intramuscular administration of amevive in taiwan patients with chronic plaque psoriasis

the purpose of the present study is to establish the efficacy and safety of one course of once weekly 15 mg intramuscular (im) administration of amevive in an alternate study population and to address the issue of peak time to response by measuring the proportion of patients achieving a ≥ 75% reduction in pasi at any time after completion of treatment.

Eligibility criteria:
inclusion criteria: * must give written informed consent * must be \>= 16 years of age * must have been diagnosed with chronic plaque psoriasis at least one year and require systemic or phototherapy * must have cd4+ lymphocyte count at or above the lower limit of normal * must have a bsa \>= 10% exclusion criteria: * current erythrodermic, generalized pustular, or guttate psoriasis * serious local infection or systemic infection within 3 months prior to the first dose of alefacept * history of any clinical significant disease that would be contraindicated for this study as determined by the investigator * prior history of systemic malignancy, untreated localised skin canceer or a \>10 squamous cell carcinoma * current enrollment in any other investigational drug study within 30 days prior to study drug administration * treatment with systemic immunosuppressant agents within the 4 weeks prior to study drug administration.

Keywords: psoriasis alefacept
the effect of rehabilitation training on orthostatic hypotension in parkinson's patients

Conditions: Orthostatic Hypotension

Summary: the goal of this clinical trial is to explore raise-bed training orthostatic hypotension in parkinson's patients. the main question it aims to answer is: can raise-bed training improve orthostatic hypotension in parkinson's patients. patients will be randomly allocated into the control group or the experimental group, all under rehabilitation treatment, the experimental group will be given raise-bed training. the study lasts 21 days for each patient. researchers will compare orthostatic hypotension questionnaire, orthostatic grading scale, composite autonomic symptom scale 31 to see if raise-bed training can help improve the symptom.

orthostatic hypotension is common in parkinson's patients. the goal of this clinical trial is to explore raise-bed training orthostatic hypotension in parkinson's patients. the main question it aims to answer is: can raise-bed training improve orthostatic hypotension in parkinson's patients. patients will be randomly allocated into the control group or the experimental group, all under rehabilitation treatment, the experimental group will be given raise-bed training. the study lasts 21 days for each patient. researchers will compare orthostatic hypotension questionnaire, orthostatic grading scale, composite autonomic symptom scale 31 to see if raise-bed training can help improve the symptom.

Eligibility criteria:
inclusion criteria: * confirmed diagnosis of parkinson's disease * presence of orthostatic hypotension, defined as a decrease in systolic blood pressure of at least 20 mmhg or a decrease in diastolic blood pressure of at least 10 mmhg within three minutes of standing up * age 40 years or older * willingness to participate in the study and provide informed consent exclusion criteria: * severe cardiovascular disease or other medical conditions that would make head-up tilt treatment unsafe or inappropriate * use of medications that affect blood pressure or heart rate, such as beta-blockers or vasodilators, and inability or unwillingness to discontinue these medications for the study period * history of syncope or falls within the past six months * inability to stand or sit up independently or tolerate changes in body position * cognitive impairment or inability to provide informed consent
smartwatch app for vibration stimulation

Conditions: Stroke; Physical Disability

Summary: the objective of this study is to determine if the acute effect of vibration from a smartwatch on hand function is comparable to the effect of an existing laboratory prototype.

more than 4 million stroke survivors in the u.s. suffer from post-stroke hand disability. as hands are our primary means of interacting with the world, post-stroke hand impairment diminishes stroke survivors' abilities for activities of daily living including self-care, hygiene, employment, and leisure, and lowers independence. hand impairment is difficult to treat. limited resources in rehabilitation services and financial burdens make it impractical to simply increase rehabilitation service visits within the current healthcare system. one way to augment hand function recovery is peripheral sensory stimulation. afferent input is a powerful driver of change in the motor cortex. sensory stimulation has been shown to improve motor recovery in previous studies. in particular, promising preliminary results have been obtained by using imperceptible random-frequency vibration applied via a watch. however, the laboratory prototype device for delivering this vibration must be improved in the form factor for patient adoption. therefore, we developed an app that can be installed in smartwatches and control the vibrator within the smartwatch to deliver vibratory stimulation to the user. the objective of this study is to determine if the acute effect of vibration from a smartwatch on hand function is comparable to the effect of an existing laboratory prototype.

Eligibility criteria:
inclusion criteria: * age = 18 or older * at least 6 months post stroke * the ability to perform the box and block test with a score greater than zero and less than 40. exclusion criteria: * rigidity (modified ashworth scale=5) * complete upper limb deafferentation * comorbidity (peripheral neuropathy, orthopaedic conditions in the hand that limit ranges of motion, premorbid neurologic conditions, compromised skin integrity of the hand/wrist due to long-term use of blood thinners) * language barrier or cognitive impairment that precludes following instructions and/or providing consent.

Keywords: physical stimulation subliminal stimulation stroke rehabilitation upper extremity paresis hand function occupational therapy physical therapy
long term outcome women who undergone mid-urethral sling surgery

Conditions: Stress Urinary Incontinence

Summary: the patients who underwent mid-urethral sling surgery for stress urinary incontinence will evaluate. the aim of our study is to assess long term surgical outcomes and post operative clinical findings include physical examinations, quality of life questionnaires, ultrasonographic measurements.

patients who underwent mid-urethral sling surgery in ankara university obstetrics and gynecology department since 2007 will be included. primary outcome measure is to describe factors effecting long term success in mid-urethral sling surgery.

Eligibility criteria:
inclusion criteria: * undergoing surgery in ankara university obstetrics and gynecology department since 2007 * patients come to follow up exclusion criteria: * inability in verbal and written communication * impairment in cognitive functions

Keywords: trans-obturator tape tension-free vaginal tape mid-urethral sling surgeries stress urinary incontinence
group-based contingency management for substance abuse treatment - 1

Conditions: Substance Abuse

Summary: the purpose of this study is to evaluate the efficacy of prize-based contingency management (cm) when administered exclusively in groups. substance dependent patients (n=360) at community-based treatment programs are randomly assigned to one of two conditions: (a) standard, non-cm treatment or (b) standard treatment plus prize cm delivered in groups. in the cm condition, patients earn the opportunity to win prizes for attending groups and submitting drug-free biological specimens. substance use and psychosocial problems are measured at intake, month 1, month 3 (post treatment), and at 6-, 9-, and 12-month follow-up evaluations. we also assess patient characteristics that may be associated with improved outcomes within and across conditions.


Eligibility criteria:
inclusion criteria: * age \> 18 years * current dsm-iv diagnosis of cocaine, opioid or alcohol abuse or dependence * willing to provide breath and urine samples for 12 weeks * english speaking * willing to sign informed consent exclusion criteria: * serious, uncontrolled psychiatric illness (e.g., acute schizophrenia, bipolar disorder, severe or psychotic major depression, or suicide risk) * dementia (\<23 on the mini mental state exam; folstein et al. 1975) * in recovery from pathological gambling

Keywords: contingency management substance abuse treatment
dysplasia in inflammatory chronic idiopathic colitis long-standing

Conditions: Dysplasia in IBD

Summary: chronic intestinal inflammation produce dysplasia more frequently than the normal population. the therapies protect against these changes, but do not rule out dysplasia. it is not known the effect of different therapies protection.

the literature data show that the inflammatory bowel diseases (rectal ulcerative colitis and crohn's disease) determine an increased risk of developing dysplasia and cancer of the colon and rectum, for the chronic inflammation that they fee, with the differences that the two diseases arise. the progression from normal mucosa to dysplasia and then to cancer is more rapid than in the adenoma-carcinoma sequence. in patients with idiopathic chronic inflammatory colitis drug therapies in use reduce the incidence of dysplasia. a systematic review concluded in favor of a chemo preventive effect of mesalazine. in any case, it has been reported protective association between use of mesalazine and cancer associated with colitis (colitis associated carcinoma cac) with an odds ratio of 0.51 per cac / dysplasia. this data, in subsequent studies, including recent ones, have remained controversial. the introduction of biological drugs in the treatment of patients with inflammatory bowel disease (ibd) has changed the quality of life and also the natural history of the disease. it is not known what biological drugs have improved the clinical history of these diseases by changing the incidence of dysplasia and colorectal cancer. the treatment of idiopathic inflammatory bowel diseases (ibd), the last decade has seen profound changes and, now, the use of biological drugs is frequent in the moderate-severe forms, especially if extended. mesalazine has in the indication of mild to moderate forms of therapy.

Eligibility criteria:
inclusion criteria: * long standing colonic inflammatory bowel disease * clinical, endoscopic and histological remission * completeness of data exclusion criteria: * important comorbidities * family history of colorectal cancer * insufficient data
trial of ultrasound guided femoral nerve block on isolated femur fracture using echo friendly needles

Conditions: Pain

Summary: this study aims to determine if there is any difference in the success rate of ultra-sound guided femoral nerve block performed with an echogenic needle versus a standard needle.

to date, the published information regarding ultrasound guided femoral nerve blocks (fnb) using echo friendly needle is very limited. more so, there is even less information regarding ultrasound guided nerve blocks using echogenic versus standard of care needles. this study hopes to add to the general knowledge of pain management in the emergency department (ed) setting and provide a unique perspective on ultrasound-guided techniques using echogenic needles to enhance accuracy and success rate of nerve blocks in ed patients. the study design will have two comparative arms; in both arms we use the same local anesthetic which is bupivacaine 0.25% with epinephrine; in all cases a total of 15 ml will be injected around the femoral nerve. once identified with ultrasound, 5 ml will be injected at lateral, medial, and posterior aspect of the nerve. the experimental arm will receive an fnb using an echogenic needle; and the control group will receive an fnb using standard of care needles.

Eligibility criteria:
inclusion criteria: * patients who present to the emergency department (ed) with isolated femur fracture (no other injuries) * patients who are cognitively alert and are able to verbalize their pain using a visual analog scale (vas) * patients who are mentally competent to consent for the study * patients who can communicate in english or spanish exclusion criteria: * gestation * prisoners * patients who cannot communicate in english or in spanish * patients who have other significant injuries besides a femur fracture * patients who are cognitively impaired and/or unable to verbalize their pain using a visual analog scale (vas) * patients with allergies to local anesthetics * patients with severe liver disease * patients with existing peripheral neuropathies in the affected limb * patients with history of complications from previous femoral blocks * patients with contraindications for needle insertion at inguinal area * local signs of infection * patient on anticoagulants and/or with history of coagulation disorders
mobile service robot for task-oriented stroke therapy: user evaluations

Conditions: Stroke

Summary: by developing an affordable mobile service robot for therapeutic activities in a health center environment, this project addresses the issue of both the high cost and man-power required to provide rehabilitation for stroke survivors and other patients. our goal is to measure users - clinician and patient - responses to a telepresence robot, vgo, that has been modified with a humanoid torso robot, nao, to facilitate remote communication between the patient and clinician, and to complete supervisory exercise coaching.

this is a short demonstration and survey study. clinical staff and patients will be gathered together and our idea for the mobile service robot will discussed. a demonstration of the telepresence feature of the robots and the nao robot greeting and helping them with simple exercises will follow (e.g., pick up and object that is handy and lift their hands over their heads). the approximately 30-minute demonstration part of the study will start with an introduction and explanation about the project and a short speech about the rehabilitation and robotics lab. after the demonstration the oral consent will be read and surveys will be handed out to those study participants who agree to complete them; if necessary, the research team will assist the study participant with the survey. surveys will then be collected, and the group will be thanked by the research team.

Eligibility criteria:
inclusion criteria: * certified rehabilitation healthcare professionals * participants with upper extremity disabilities * participant must be older than 18 years exclusion criteria: -less than 18 years of age

Keywords: upper extremity stroke rehabilitation robotics telepresence elderly aged housing for the elderly retirement homes for the aged