Kornimate/medical-research-clean huggingface dataset:
begrow study to treat pulmonary artery (pa) stenosis in newborns and infants

Conditions: Pulmonary Artery Stenosis

Summary: objective of the study is to assess safety and performance of the begrow stent system for newborns and infants in pulmonary artery stenosis.

the bentley innomed "begrow stent system for newborns and infants" is a stent delivery system indicated for intraluminal placement in the pulmonary arteries of newborns and infants for the treatment of pulmonary artery stenosis.

Eligibility criteria:
inclusion criteria: * single lesion(s) which can be treated with a 6 mm begrow stent (only one stent per lesion allowed). * pulmonary artery stenosis - patient must at least have one of the following diseases: * haemodynamically relevant proximal or distal branch pulmonary artery stenosis with a reduction of the vessel diameter when the vessel/patient is large enough to accommodate a stent, * haemodynamically relevant stenosis of the main pulmonary artery segment that results in elevation of the right ventricle (rv) pressure, provided that the stent definitely will not compromise a functioning pulmonary valve and will not impinge on the pulmonary artery bifurcation, * any degree of stenosis in patients with single ventricle circulation * critically ill postoperative cardiac patients when it has been determined that branch pulmonary artery stenosis is resulting in a definite haemodynamic compromise in a patient/vessel of any size, particularly if balloon dilatation is unsuccessful * signed written informed consent (by parents/legal guardians) * lesion can be accessed with a guide wire or balloon catheter * age ≤ 24 months and weight ≥ 2 kg * adequate stent length available exclusion criteria: * the following lesions are excluded from treatment with begrow stent: * shunt stenosis * valvular and subvalvular pulmonary stenosis * patients with known hypersensitivity to the stent material (l605 cobalt-chromium). * patients with clinical or biological signs of infection. * patients with active endocarditis. * patients with known allergy to acetylsalicylic acid, other antiplatelet agents or heparin. * presence of other previously implanted stents in the same lesion or in close proximity to stent (direct stent-stent contact). * patients with known coagulation disorder. * patients where direct stent-stent contact or overlapping cannot be avoided. * patients where contact to the vessel wall over the entire stent length cannot be ensured after dilatation (especially in short and thick lesions). * patients where the begrow stent could protrude freely into adjacent vessels after expansion/dilatation, including the pulmonary arterial bifurcation. * implantation of the begrow stent in the pulmonary arterial bifurcation.
effect of music in labor in women who underwent induction of labor

Conditions: Labor Pain

Summary: women's experience of pain during labor varies greatly, and pain control is a major concern for obstetricians. several methods have been studied for pain management for women in labor, including drug and non-drug interventions most methods of non-pharmacological pain management are non-invasive and appear to be safe for mother and baby, including immersion in water, relaxation, acupuncture, and massage. however, their efficacy is unclear, and based mostly on non-randomized studies. on the other hand, there are strong data to support the efficacy of pharmacological methods, including epidural analgesia, which improves pain relief but increase the incidence of operative vaginal delivery recently a clinical trial showed that music in labor was associated with maternal benefits in women who underwent spontaneous vaginal delivery. however, the effect of music in labor in women undergoing induction of labor is still a subject of debate.


Eligibility criteria:
inclusion criteria: * nulliparous women * singleton gestation * vertex presentation * induction of labor, i.e. cervical ripening with prostaglandins * gestational age between 37 and 42 weeks exclusion criteria: * multiparous womne * multiple gestations * preterm labor * preterm premature rupture of membranes * induction of labor with oxytocin and without prostaglandins * induction of labor with balloon * high risk pregnancies, including hypertensive disorders of pregnancies, diabetes, intrauterine growth restriction, fetal abnormalities.
tryptophan and behavior therapy for cocaine abuse - 1

Conditions: Cocaine-Related Disorders

Summary: the purpose of this study is to assess the efficacy of tryptophan vs. placebo, and voucher payments vs. a control condition, in the treatment of cocaine dependence.

this clinical trial uses a 2 by 2 design to compare tryptophan to placebo, and voucher incentives vs. a control condition, in the outpatient treatment of cocaine dependence- using a relapse prevention model of treatment intervention.

Eligibility criteria:
inclusion criteria: * cocaine dependent exclusion criteria: * physically dependent on drugs of abuse other than cocaine * significant medical or psychiatric illness (besides substance abuse disorder) * pregnant
transcriptomic analysis of circulating endothelial cells during sepsis - traces study

Conditions: Critical Illness With or Without Sepsis

Summary: vascular dysfunction is an important mechanism involved in organ failure, in the setting of sepsis condition, with different types of circulating endothelial cells.transcriptom analysis via rnaseq in different types of circulating endothelial cells, comapring critically ill patients with or without sepsis will allow determining differential gene expression for signal pathways in endothelial alteration and restoration associated with sepsis.


Eligibility criteria:
inclusion criteria: * age between 18 and 85 years * admission in intensive care with or without sepsis * health insurance as per the national insurance system * informed and unopposed patient for participation (or referend closed one) exclusion criteria: * patient under legal protection * patient under national medical help system * pregnancy
incidence of mri sacro-iliac joint anomalies in young women

Conditions: Women (Between 18 to 50 Years Old); Sacro-iliac Joints; Inflammatory Lesions; Structural Lesions; Axial Spondyloarthritis

Summary: prospective multicenter study assessing the incidence of inflammatory and structural lesions seen on mri of the si joints in a consecutive population of women aged 18-50 years old. the study hypothesis is spa may be misdiagnosed on mri in post partum women due to increased stress on the joint following pregnancy and childbirth, as mri of the si joints may show lesions that could mimics axial spondyloarthritis. the primary objective of this study is to determine the incidence of si lesions seen at mri in women. the secondary objectives are to compare the incidence and pattern of mri inflammatory and structural lesions of the si joints and to determine the factors associated with inflammatory or structural changes of the si joints in a population of women. the investigators will especially compare the population of women within a year after childbirth versus the population of women who never gave birth or who gave birth over 24 months ago or more.

500 women aged of 18 to 50 years old, including 100 women who gave birth within the year, referred to the imaging department for pelvic mri for the exploration of pelvic or gynecologic pathology will be recruited consecutively. mri will be performed on a 1.5 t mri according to standardized exploration of the pelvis and will include axial t1-weighted sequences and t2stir (or t2 fat sat or t2 dixon) of maximum 6 mm thickness . an additional axial stir sequence may be added as part of the research (duration 3 minutes), if the standard protocol does not include any stir, t2 fat sat t2 or t2 dixon sequence. si lesions will be assessed in a centralized randomized and independent review of all mr images by 2 musculoskeletal radiologists according to asas criteria. patients will complete a standardized questionnaire on the day of mri to collect the following data : patient's and family history of chronic inflammatory disease, number and date of pregnancies, practice of sports, back pain, joint pain.

Eligibility criteria:
inclusion criteria: * women aged 18 to 50 years old * mri of the pelvis requested as part of an exploration of a gynecological or pelvic pathology * women who delivered within the year or women who never gave birth or gave birth 24 months ago and over exclusion criteria: * patients with a personal or family history of inflammatory disease (spa , ulcerative colitis , chron , pso , ra, sapho) * patients with a history of trauma or surgery of the pelvis * pregnant women * women who gave birth over a year ago and less than 2 years ago

Keywords: magnetic resonance imaging (mri) sacro-iliac joints pelvis erosion fat deposit subchondral sclerosis bone marrow edema axial spondyloarthritis
exploratory study on the role of the digestive microbiota in adults living with hiv-1

Conditions: HIV

Summary: chronic immune activation present in aviremic people living with hiv under treatment promotes the onset of insulin resistance and metabolic syndrome, paving the way for the comorbidities that are currently the main causes of morbidity. this activation continues despite effective antiretroviral therapy. in the activih study (nct02334943) the analysis of 68 ai markers allowed classification of 120 aviremic plhiv under treatment for at least 2 years according to 5 different immune activation profiles. among these 5 profiles, profile 2 was characterized by high blood pressure figures, high waist sizes, low hdl-cholesterol levels, high triglyceridemia, and especially hyperinsulinemia. several studies have shown that the digestive microbiota of this population is less rich and less diverse than that of healthy subjects. however, the digestive microbiota and in particular bacterial proteins and metabolites seem to play a key role in immune activation in people living with hiv. finally, the digestive microbiota has already been shown to have an impact on insulin sensitivity. the study investigators hypothesize that a particular digestive microbiota could promote the appearance of profile 2. this microbiota could be the cause of digestive dysbiosis leading to intestinal inflammation, digestive permeability and bacterial translocation.


Eligibility criteria:
inclusion criteria: * patient informed of the implementation of the study, its objectives, its constraints and the patient's rights. * male and caucasian patient. * patient with hiv-1 infection determined by positive serology or plasma viral load (hiv rna) measurement. * patient on effective triple antiretroviral therapy, stable for more than 6 months, with a plasma viral load \<50 copies / ml for at least 6 months before inclusion (2 measurements). * patient whose immune activation profile has been characterized beforehand (profiles 1, 2, 3, 4 and 5). * the patient must have given their free and informed consent and signed the consent form * the patient must be a member or beneficiary of a health insurance plan exclusion criteria: * vulnerable person according to article l1121-6 of the csp. * adult person protected according to article l1121-8 of the csp. * patient presenting with a non-infectious pathology which may be the cause of an immune abnormality. * patient having undergone treatment with an immunomodulator molecule or chemotherapy within 60 days before inclusion in the research or has an indication planned for the duration of the research. * patient with a chronic digestive pathology or who had been operated on the previous year * the subject is participating in a category 1 interventional study, has participated in another interventional study in the last 3 months or is in a period of exclusion determined by a previous study * the subject refuses to sign the consent * it is impossible to give the subject informed information * the patient is under safeguard of justice or state guardianship
interpretation of endoscopic characteristics of colorectal polyps with blue light imaging

Conditions: Identification of Colorectal Polyps

Summary: interpretation of endoscopic characteristics of colorectal polyps with blue light imaging a study of bli images and videos of colorectal polyps will be presented initially as a training set followed by with explanation and teaching in a didactic session to two separate groups. a post-test will be conducted to look at the quality of the learning experience. to evaluate the teaching tool regarding the criteria for bli images of colorectal polyps by the following measures * inter-observer agreement between same and different groups * accuracy in describing the morphology of colorectal polyps • this new teaching tool will improve * inter-observer agreement by at least 5%- 10% (depending on the group) * accuracy by at least 5%- 10% (depending on the group)• to determine the improvement of inter-observer agreement in identifying/ describing colorectal polyps after the didactic session in both the groups * overall accuracy, sensitivity, specificity, positive predictive value and negative predictive value pre-and post-test in both the groups


Eligibility criteria:
inclusion criteria all gastroenterology attending physicians, gastroenterology fellows, residents and medical students at the va medical center exclusion criteria not willing to participate h/o colour blindness or visual impairment any intellectual disability
determining the tolerance of depigmented skin to targeted phototherapy using uvb in patients with vitiligo

Conditions: Vitiligo

Summary: the purpose of this study is to determine if vitiligo patients develop tolerance to ultraviolet light therapy, a type of treatment available for vitiligo.

patients with vitiligo received 6-9 ultraviolet b treatments, 2 to 3 times weekly. minimal erythema dose (med) testing was done at baseline and after all treatments; the percent change in med was analysed as a measure of photoadaptation. the percent decrease in cyclobutane pyrimidine dimers (cpds) over 24 hours after a single exposure of 1 med was analysed on vitiliginous and normal skin.

Eligibility criteria:
inclusion criteria: for inclusion, the subject must: 1. be at least 18 years old 2. be otherwise healthy 3. have a diagnosis of vitiligo affecting \> 5% body surface area (bsa) 4. have two depigmented lesions on opposite sides of the body that can be biopsied at the end of targeted uvb phototherapy treatment 5. agree to abide by the investigator's guidelines regarding photosensitizing drugs 6. have a negative pregnancy test at baseline if female of childbearing potential 7. be able to understand the requirements of the study, the risks involved, and is able to sign the informed consent form 8. agree to follow and undergo all study-related procedures exclusion criteria: subjects will be excluded if any of the following apply: 1. women who are lactating, pregnant, or planning to become pregnant 2. patients with a recent history of serious systemic disease 3. patients with a known history of photosensitivity 4. concomitant use of systemic or topical treatments for vitiligo. patients must discontinue puva or oral corticosteroid therapy for 4 weeks prior to the start of any treatment. if a patient is taking any vitamins or dietary supplements, the patient must discontinue them for the duration of the study. topical therapy such as corticosteroids, topical immunomodulators (e.g., protopic or elidel), vitamin d derivatives (e.g., dovonex), or uvb phototherapy must be discontinued for 2 weeks prior to the start of study treatment. 5. patients diagnosed to be immunosuppressed for any reason (e.g., hiv infection, lupus, cancer, organ transplant, or chronic use of oral immunosuppressive agents). 6. any reason the investigator feels the patient should not participate in the study

Keywords: vitiligo tolerance ultraviolet b.
effects of combined resistance and aerobic training vs aerobic training on cognition and mobility following stroke

Conditions: Cerebrovascular Accident

Summary: both aerobic training (at) and resistance/strength training (rt) have the potential to improve recovery after stroke. research conducted in chronic disease and healthy populations suggest that at and rt "combination therapy" may produce synergistic and superior effects along cognition and mobility domains, when compared to at alone. however, the effects of a combined training approach (at+rt) compared to at alone has not been investigated in people post-stroke.

patients referred to toronto rehabilitation institute's risk factor modification and exercise program following stroke (tri-reps) will be randomized to either at+rt or at alone. mobility (6 minute walk test), and cognition (vascular cognitive impairment harmonization standards) will be measured pre- post 6 months of exercise. secondary measures will include body composition, and biochemical changes. this project will help to determine an exercise treatment strategy that will guide best practice guidelines aimed at promoting mobility and brain health in people post-stroke.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of stroke (ischemic or hemorrhagic) * ability to walk at least 100 m independently with or without an assistive * device with no severe limitations due to pain * living in the community at least 3 months post stroke (no upper limit) * stroke-related motor impairment score of 3-6 on the chedoke-mcmaster stroke * assessment scale of the leg and/or foot * ability to provide informed consent exclusion criteria: * unstable angina or orthostatic blood pressure decrease of \> 20 mmhg * resting hypertension (sbp \> 160 mm hg or dbp \> 100 mm hg) * diabetes related or other eye/vision complications (severe proliferative retinopathy) * cardiovascular morbidities which would limit exercise tolerance (e.g. heart failure, hypertrophic cardiomyopathy, horizontal or downsloping st-segment depression \> 2 mm, symptomatic aortic stenosis, complex arrhythmias) * musculoskeletal impairments which would preclude safe participation in exercise * cognitive and/or behavioral issues that would significantly limit participation in exercise testing and training, prior unrelated neurological disorders or psychiatric illness * severe communicative aphasia or comprehensive aphasia (as noted in clinical reports) * patients with anxiety disorder, claustrophobia, or pacemaker implantation will be excluded from brain imaging and perfusion measures * exposure to a similar or identical neuropsychological battery within \<6 months * currently smoking

Keywords: exercise therapy rehabilitation
evaluation of the impact of the level of mindfulness on the management of patients with recurrent depressive disorders by the mindfulness based cognitive therapy ( mbct ): an exploratory study

Conditions: Patients With Recurrent Depressive Disorders

Summary: mindfulness is both a natural resource of individuals present in all individuals in varying degrees characteristic ability of attention to the experience that unfolds moment by moment without judgment and a practice based on meditation, mindfulness exercises, which aims to enhance two central skills of mindfulness that are the presence and acceptanc. in the context of recurrent depression, the practice of mindfulness meditation in the frame of mbct is recognized as effective in psychological suffering and relapse. the mechanisms implied in mbct efficacy are emotional but especially cognitive. among the cognitive mechanisms, reduction of rumination is a major factor in the action of mbct, especially for patients with less than three depressive relapses. this exploratory research focuses on the impact of mindfulness functioning (mindfulness resource level at baseline) on the benefits of mbct for patients with recurrent depressive disorder. the objective is to assess whether the level of mindfulness resource of patients with recurrent depression is a factor contributing to the positive effect of a mbct applied in add-on to conventional care. this objective will be measured by comparing the clinical improvement of patients secondary to mbct according to the initial categorization of the mindfulness resource. clinical improvement will be more important for patients characterized by a lower initial level of mindfulness resource.


Eligibility criteria:
inclusion criteria: major patient patient with recurrent depression patient have read, understood and signed the non-opposition form. exclusion criteria: inability to understand or read english or french. individuals unable to personally express their opposition not under whose major legal or private protection of liberty by judicial or administrative decision, or hospital emergency
addressing disparities in autism spectrum disorder diagnosis using a direct-to-home telemedicine tool

Conditions: Autism Spectrum Disorder

Summary: the investigators propose to evaluate the use of a telemedicine tool, the tele-asd-peds (tap), that is designed to assess for autism spectrum disorder (asd) symptoms in toddlers. the tap was developed at vumc by a team of clinical psychologists with expertise in the early identification of asd. the tap has been studied in controlled laboratory settings, with high levels of family and clinician satisfaction, as well as excellent agreement with blinded comprehensive asd evaluation. the tap has also been used to complete direct-to-home telemedicine assessments during the covid-19 pandemic. however, the investigators have not yet compared direct-to-home assessments using the tap with gold standard, in-person asd assessments. it has also not yet been studied in a diverse sample of families or with providers outside of vumc. this study will allow the investigators to address those gaps.

the investigators propose to evaluate the use of a telemedicine tool, the tele-asd-peds (tap), that is designed to assess for autism spectrum disorder (asd) symptoms in toddlers. this study will recruit 360 toddlers (18-42 months of age) across two sites (vumc and the university of california, davis). all toddlers will receive in-home telemedicine assessment for asd using the tap. this study has two aims. the first aim will randomize participants to receive either (1) telemedicine assessment and an in-person asd assessment or (2) telemedicine-based assessment only. the investigators will measure diagnostic accuracy of the tap in comparison to gold standard, in-person asd assessment. the investigators will also assess test-retest reliability, inter-rater reliability, and the sensitivity, specificity, and positive predictive value of the tap. in the second aim, all 360 families will be followed over six months to evaluate service access, family engagement, and family perceptions of the diagnostic process.

Eligibility criteria:
inclusion criteria for children: * child between 18 and 42 months of age * child and primary caregiver live within a 3-hour driving radius of one of the sites (i.e., vumc or uc davis) inclusion criteria for caregivers: * age 18 years or older * parent or legal guardian of participating child * has access to technology (e.g., phone, laptop, or tablet with internet connection and audio-visual capabilities) to connect to the tele-assessment platform * sufficient facility with english to participate in the procedures and complete study measures. exclusion criteria for children: * severe sensorimotor impairment that cannot be corrected and would interfere with completion of study activities * medical conditions for which tele-evaluation of asd symptoms is likely to be inappropriate or complex (i.e., rare genetic syndromes, severe epilepsy, fragile health).

Keywords: autism spectrum disorder tele-assessment