Kornimate/medical-research-clean huggingface dataset:
cross body vs sleeper stretch on pain, range of motion and functional performance in cricket bowlers.

Conditions: Pain; Range of Motion; Physical Functional Performance

Summary: the study is randomized and single-blinded. ethical approval is taken from ethical committee of riphah international university, lahore. participants who meet the inclusion criteria will be enrolled and allocated in group a \& b through sealed envelope method by non-probability convenient random sampling technique. subjects in group a will receive sleeper stretch in a side lying position. group b will receive cross-body stretch will be done in sitting position

the objective of the study is to determine the comparison of sleeper stretch and cross body stretch on pain, range of motion and functional performance in cricket bowlers with gird. the study is randomized and single-blinded. ethical approval is taken from ethical committee of riphah international university, lahore. participants who meet the inclusion criteria will be enrolled and allocated in group a \& b through sealed envelope method by non-probability convenient random sampling technique. subjects in group a will receive sleeper stretch in a side lying position. group b will receive cross-body stretch will be done in sitting position. a universal goniometer, upper limb functional index (uefi) scale and numeric pain rating scale (nprs) will be used at the baseline and after the completion of treatment at 6 weeks. the data will be analyzed by spss, version 25. statistical significance is p=0.05.

Eligibility criteria:
inclusion criteria: * age 20 to 30years, * both male and female, * \>10% ir deficit, * \>25% ir deficit related to contralateral limb, * athletes one year of regular practice, * lift off test for shoulder internal rotation positive. exclusion criteria: * non players, * any nerve lesions of upper limb, * players with history of shoulder pain or fracture or dislocation in less than twelve months

Keywords: cross body stretch sleeper stretch functional performance glenohumeral internal rotation deficit cricket bowlers
book sharing for toddlers with clefts

Conditions: Cleft Palate; Cleft Lip and Palate

Summary: children with clefts exhibit difficulty with language and literacy compared to children without clefts. however, little is known about interventions to address these difficulties in the cleft population. this study will test the efficacy of a parent-focused dialogic book-sharing intervention for toddlers with isolated cleft palate. the study will use a randomized controlled trial (rct) design and intention to treat (itt) analyses. child outcomes include expressive and receptive language. parent outcomes of interest include the frequency and quality of shared reading interactions. to assess mechanisms of action, the study will test whether changes in child outcomes are mediated by changes in parents' behavior. analyses will also explore heterogeneity in outcomes to determine whether the intervention is more effective in certain clinical or demographic sub-groups.


Eligibility criteria:
inclusion criteria: * a child's parent or primary caregiver provides a signed and dated informed consent form and permission for their child to participate. * a child's parent is willing to comply with all study procedures and be available for the duration of the study. * child is between the ages of 20 to 32 months at the time of enrollment. * child has been diagnosed with isolated cleft palate, with or without cleft lip. * child has received palate repair surgery. * the family's preferred language is english or spanish. * the family has access to a smartphone or similar device (e.g., tablets) capable of recording and sending videos. exclusion criteria: * diagnosed genetic condition associated with developmental delay (e.g., 22q11 deletion). * the child has a diagnosis of autism spectrum disorder * the child has a tracheostomy tube * child delivered \< 32 weeks' gestation. * child in state custody or foster care. * child with significant sensory impairment (blindness, sensorineural hearing loss). * the caregiver speaks a language other than english or spanish * the caregiver does not own a smartphone or similar device capable of recording/sending video
scintigraphy study to assess gastric emptying in healthy subjects given gsk716155 or placebo.

Conditions: Diabetes Mellitus, Type 2

Summary: this study will use scintigraphy techniques to measure gastric emptying rate of liquid and solid food at baseline and after administration of gsk716155 or placebo.


Eligibility criteria:
inclusion criteria: * healthy men or women, between the ages of 18 and 65, and have a body mass index (bmi) of between 20 and 32. * if female, the subject must be not be capable of having children. exclusion criteria: * subjects must not use tobacco, nicotine, or illegal drugs of abuse, and must not take caffeine or alcohol for 24 hours before dosing and before each set of scintigraphy procedures. * subjects may not have hiv, hepatitis, elevated fasting blood sugar levels, high blood pressure, heart, lung, liver, gall bladder, gastrointestinal, pancreatic, or kidney disease, or untreated thyroid disease. * subjects must not have a history of alcohol abuse, must not take prescription or non-prescription drugs within 7 days of day 1 and day 8 of the study, and must not have previous exposure to any glp-1 mimetic or exenatide. * prior radiation exposures must meet certain limits in order to participate in this study.

Keywords: healthy pharmacodynamics glucagon-like peptide 1 pharmacokinetics scintigraphy radiation albiglutide
a clinical trial to assess the acute safety and functional outcome and recovery after stroke: the first trial

Conditions: Stroke

Summary: current literature has only limited information on the natural history of acute ischemic stroke from large vessel occlusion in a stroke cohort who presents within 8 hours from symptom onset, particularly on 90 day functional outcome as defined by the mrs. data from this trial will advance our knowledge on this important topic and may serve as a bench mark for future trials


Eligibility criteria:
inclusion criteria: * from 18 to 85 years of age. * evidence of proximal anterior circulation large vessel occlusion (timi 0-1)(tici 0-1) from ct angiography. target vessel occlusion may include the anterior circulation. * presented with symptoms consistent with acute ischemic stroke within 8 hours of symptom onset. patients who presented within 3 hours must be ineligible or refractory to iv rtpa therapy. * at time of enrollment, neurological deficit resulting in an nih stroke scale (nihss) score greater than 10 * known core infarct volume assessed by ctp, cta or dwi scans exclusion criteria: * history of stroke in the past 3 months. * pre-existing neurological or psychiatric disease that could confound the study results such as a pre-stroke mrs score greater than 1 * known severe allergy to contrast media * uncontrolled hypertension (defined as systolic blood pressure greater than 185 mmhg or diastolic blood pressure less than 110 mmhg) * ct evidence of the following conditions before enrollment: * significant mass effect with midline shift * evidence of intracranial hemorrhage * treated with endovascular therapy for acute stroke * life expectancy less than 90 days * participation in another clinical investigation that could confound the evaluation of the study

Keywords: acute ischemic stroke, large vessel occlusion, natural history, functional outcome
neuroplasticity after proprioceptive rehabiliation

Conditions: Stroke; Hemiparesis; Traumatic Brain Injury

Summary: sequences of muscle tendon vibrations allow to reproduce the sensory feedback during movement like locomotion and kinaesthesia. it is known that such a treatment promotes motor recovery after stroke assuming that it enhances neuroplasticity. the aim of the research is to study the activity in cerebrospinal circuitry to evaluate the neuroplastic changes during and after instrumented proprioceptive rehabilitation relying on sequences of muscle vibration in subacute stroke stages.

randomized control trial : 28 patients with active vibrations vs. 28 patients with sham stimulation subacute phase : d15 to 6 months after stroke or patients with traumatic brain injury with similar semiology as stroke (hemiparesis) measure at baseline : electrophysiological investigations (emg,eeg, mri, clinical evaluation) treatment of 5 weeks with 3 sessions of vibrations or sham a week evaluation at mid time (electrophysiology and clinical examinations) final examination (electrophysiology, mri and clinical examination)

Eligibility criteria:
inclusion criteria: * hemiparesis at least transient in lower limb following an acquired brain injury (stroke or traumatic brain injury) * french spoken * affiliated to a french social insurance * no previous traumatic, vascular or neurodegenerative injuries * having presented during the acute phase or presenting a motor deficit of one of the lower limbs * presenting an absence of autonomy of walking at the entrance of the rehabilitation department * in the sub-acute phase, i.e. from 15 days to 6 months after the accident * presenting moderate cognitive disorders allowing them to understand instructions and give their consent exclusion criteria: * strong cognitive disorders * maintenance of justice, tutelage, legal guardianship * pregnancy and breastfeeding * outpatients who do not have weekly follow-up in the rehabilitation department

Keywords: neuroplasticity electrophysiology mri neurophysiology muscle vibration
study to evaluate a preop dose of brivoligide injection for pain after mastectomy in patients with high pcs scores

Conditions: Pain, Postoperative

Summary: this is a multiple center, randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of brivoligide injection administered intrathecally before surgery in patients with high pain catastrophizing scale (pcs) scores undergoing mastectomy with immediate tissue expander or implant placement.

potential subjects will be prescreened for pcs score; pre-qualified patients will be invited to the investigative site for informed consent and full screening within 30 days of randomization. patients providing informed consent and meeting all study eligibility criteria will be enrolled in the study on the day of surgery (day 1). subjects will receive study drug just prior to anesthesia induction. study assessments will be entered by subjects in the electronic diary from day 1 through day 21. follow-up visits will occur on days 7 and 21 (± 2 days).

Eligibility criteria:
inclusion criteria: * score of 16 or greater on the pcs scale * scheduled to undergo unilateral or bilateral mastectomy with immediate tissue expander or implant placement * american society of anesthesiologists physical status classification system ≤ 3 * medically stable for this surgery with general anesthesia and intrathecal administration of study drug as determined by the investigator * body mass index of 18-45 kg/m2 * have a stable medical regimen (for prescribed medications) for ≥ 7 days before randomization * able to read and understand study instructions in english or spanish, and willing and able to comply with all study procedures exclusion criteria: * prior breast surgery in the index breast (either breast for bilateral surgery) in the last two years, other than biopsies and small/moderate volume lumpectomies * induction chemotherapy or plans for adjunctive chemotherapy or any radiotherapy within 21 days of surgery * known spinal deformities or cutaneous infection in the lumbar area that would preclude intrathecal administration of study drug * planned use of liposomal formulated or long-acting local anesthetics, extended release opioid formulations (e.g., oxycontin), long half-life opioids (e.g., methadone), or drugs with potential for adverse cognitive or memory effects (e.g., ketamine, scopolamine, or propranolol) preoperatively and/or at any time through the duration of the study * use of more than 40 mg per day (on average) of oral morphine or its equivalent within 1 month prior to randomization * current neurologic disorder, which could confound the assessment of pain * unstable mental condition which would prevent the patient from understanding the nature and scope of the study and/or evidence of an uncooperative attitude in the opinion of the investigator * women who are pregnant or nursing * participation in a clinical trial with the last dose or intervention within 1 month of randomization, or planned treatment in a clinical trial during this study * previous participation in any study involving brivoligide injection

Keywords: mastectomy
sars-cov-2 in stools compared to respiratory viral strains.

Conditions: SARS-CoV-2 Infection

Summary: the aim of the study is to characterize and to quantify sars-cov-2 strains in stools, in comparison with the viral strains in respiratory samples, from patients hospitalized for covid-19. the methods will be standard ddpcr quantifying sars-cov-2 rna and next generation sequencing-whole genome sequencing. the expected results will allow us to better understand sars-cov-2 dynamics and compartmentalization, both in the respiratory tract and in digestive-related tissues, according to the evolution of sars-cov-2 variants.


Eligibility criteria:
inclusion criteria: * age: men or women of 18 years-old or more * clinical signs: hospitalised patient for sars-cov-2 infection, nasopharyngeal pcr-confirmed (or any other sample) (in: infectious diseases department, intensive care unit), whatever the severity of the clinical form. * the subject gave his/her informed and writen consent, after complete explanations on the research schedule. * compulsory affiliation to a social security scheme. * previous medical examination, when a patient is admitted to the hospital, according to good clinical practices. exclusion criteria: * subject corresponding to articles l. 1121-5, l. 1121-7 and l1121-8 of the french public health code: * pregnant woman, parturient or breastfeeding woman * minor person * person of full age under guardianship, curatorship, safeguard of justice * woman who wants to be pregnant during the study period * person in psychiatric care - articles l. 3212-1 and l. 3213-1 who do not fall under the article l. 1121-8 (without consent hospitalisation)

Keywords: covid-19; sars-cov-2
assessment of endometrial changes in postmenopausal women with breast cancer in adjuvant treatment with anastrozole

Conditions: Breast Cancer

Summary: to investigate the global incidence of the endometrial changes in postmenopausal women receiving anastrozole for the adjuvant treatment of hormone receptors positive breast cancer.


Eligibility criteria:
inclusion criteria: * provision of informed consent * resectable breast cancer patients, with histological confirmation * patients eligible to receive hormonal adjuvant treatment with anastrozole * they are allowed patients treated with adjuvant chemo or radiotherapy concurrently * patients previously treated with tamoxifen that had to withdraw treatment due to other reason than endometrial changes are allowed * postmenopausal patients(aged 50 years or over/ without menses in the last months/ fsh level \>40ui/l / women under 50 years with fsh levels\>40ui/l). * women showing progesterone and/or estrogen receptors positive. exclusion criteria: * patients with evidence of metastatic disease * patients unsuitable to receive the medication according the anastrozole label * patients not giving their informed consent

Keywords: adjuvant postmenopausal breast cancer women
evaluation of a two-tiered cross-age teaching model for food literacy-based education

Conditions: Food Literacy; Adolescent Health; Cross-age Teaching; Nutrition Education; Experiential Learning

Summary: this project will serve adolescents from low-income and historically underserved communities through expansion of existing after-school programs. adolescents from these communities tend to have slower academic progression and higher high school dropout rates. extracurricular activities, including informal education through after-school programming, have been suggested to improve these rates and increase college enrollment by supporting traditional classroom-based education. the proposed project aims to educate high school-aged adolescents in food, agriculture, natural resources, and human (fanh) sciences through informal food literacy education. the project also includes a two-tiered cross-age teaching model, allowing for adolescents to be educated by college interns and to become educators for younger youth. existing curricula, that encompass fanh sciences, will be utilized at each stage of the project. the purpose of the project is not only to educate adolescents in fanh sciences, but also to advance their motivation and efficacy for graduating high school, attending college, and majoring in fanh sciences. the project aims to accomplish these objectives through empowering adolescents to obtain knowledge, skills, and excitement for food literacy. as this model has not been utilized previously, this project will produce a best practices guide for implementing the existing curricula within a two-tiered cross-age teaching model. additionally, the college internship and mentoring program created through this project will be continued at the initial sites and expanded to other communities. this will allow for a sustainable approach to educating adolescents in fanh sciences and providing mentorship that encourages future enrollment in college.


Eligibility criteria:
inclusion criteria: * there are two groups of participants (adolescents and younger youth) that will be recruited for this study. adolescent participants must be high school-aged, approximately 13-17 years. younger youth must be upper elementary school-aged, approximately 9-12 years. participants for both age groups will be recruited from existing afterschool programs within each participating school district. comparison youth for both age groups will be recruited from other students within the same school districts. for the 2019-2020 and 2020-2021 school years, the participating school districts will be in pittsburg and williams, california. exclusion criteria: * youth from other school districts
efficacy, tolerability, and safety of dfn-15

Conditions: Migraine Headache

Summary: efficacy, tolerability, and safety of dfn-15 in episodic migraine with or without aura, being conducted at multiple centers in the united states


Eligibility criteria:
inclusion criteria: 1. a history of episodic migraine, who experience 2 to 8 migraine attacks per month for at least the past 12 months, with no more than 14 headache days per month, and with 48 hours of headache-free time between migraine attacks. 2. patients who have migraine with or without aura with onset before age 50 years 3. report usual migraine pain of 2 (moderate) or 3 (severe) on headache pain severity scale without treatment. 4. subjects who are willing and able to: 1. evaluate and record pain, migraine symptoms, and study drug effectiveness information in real-time using a subject ediary for the duration of the study; 2. record each instance of the use of study drug and rescue medication in real-time using a subject ediary for the duration of the study; 3. comply with all other study procedures and scheduling requirements. exclusion criteria: 1. minors, even if they are in the specified study age range 2. medication overuse: 1. opioids greater than or equal to 10 days during the 90 days prior to screening 2. combination medications (e.g., fiorinal®) greater than or equal to 10 days during the 90 days prior to screening (applies only if includes opioid and/or barbiturate) 3. nonsteroidal anti-inflammatory drugs or other simple medications greater than 14 days a month during the 90 days prior to screening 4. triptans or ergots greater than or equal to 10 days a month during the 90 days prior to screening 3. treated with onabotulinumtoxin a (botox®) for migraine within 4 months prior to screening. (if treated for cosmetic reasons, subjects may be included). 4. current treatment with antipsychotics or use of antipsychotics within 30 days prior to randomization. 5. patients who have received treatment with an investigational drug or device within 30 days of randomization, or participated in a central nervous system clinical trial within 2 months prior to randomization 6. patients with positive screening test for human immunodeficiency virus \[hiv\], positive hepatitis b surface antigen (hbsag), or positive hepatitis c virus \[hcv\] antibody 7. subjects who are employees or immediate relatives of the employees of the sponsor, any of its affiliates or partners, or of the clinical research study site.
precee2 perinatal research

Conditions: Pregnancy Complications

Summary: the aim of this study is to analyze the relationship between complications and adverse pregnancy outcomes and exposure to environmental factors in women living in franche-comté who gave birth between 2011 and 2025 at besancon university hospital.


Eligibility criteria:
inclusion criteria: * women who gave birth at the chub between 01/01/2011 and 12/31/2025 * who have not expressed any objection to the processing of their data. exclusion criteria: * legal incapacity or limited legal capacity * subject is within the exclusion period of another study or is excluded from the "national volunteer file". * subject refusing the collection of his/her medical data.
acceptability and efficacy of go move

Conditions: Cerebral Palsy; Hemiplegic Cerebral Palsy

Summary: the goal of this clinical trial is to learn about the acceptability and efficacy of go move, a mobile website developed to assist youth with unilateral cerebral palsy and their caregivers with setting goals and selecting exercises and activities to meet the goals. the main question\[s\] it aims to answer are: * is go move accepted by youth with unilateral cerebral palsy and their caregivers? * does go move support goal attainment for youth with unilateral cerebral palsy? participants will set up and participate in a goal-driven home program using the go move mobile website. participants will spend 1 hour and 15 minutes per week for 6 weeks working on their home program and will complete pre-intervention and post-intervention assessments.


Eligibility criteria:
inclusion criteria: * inclusion criteria for participants to enroll in the study include a diagnosis of unilateral cp or a non-progressive brain lesion, injury, or trauma of the developing brain that presents with a unilateral upper limb motor impairment. gmfcs levels 1 or 2. macs levels 1-3. age 3-17 years old, ability to follow directions, ability to complete the assessment protocol, and the ability to access the go move webpage on a personal device. all ethnic/racial groups will be eligible to participate. the ability to participate in everyday activities without restriction from a physician throughout the duration of their participation in the study (does not have restrictions/contraindications following a medical procedure). exclusion criteria: * the study will exclude any patients with uncontrolled epilepsy or significant visual impairment. the study will exclude any patient with severe behavioral problems or the inability to complete the assessment protocol or home program.

Keywords: home program