Kornimate/medical-research-clean huggingface dataset:
effect of progressive muscle relaxation exercises versus pilates exercises on postnatal low back pain

Conditions: Low Back Pain

Summary: this study was conducted to compare between the effect of progressive muscle relaxation exercises and the effect of pilates exercises on postnatal low back pain

ethical approval was obtained from the institutional review board of the faculty of physical therapy, cairo university, before starting this study \[no: p.t.rec/012/003885\]. the study's protocol was explained in detail to each woman who signed an informed consent form before starting this study. this work adhered to the principles outlined in the declaration of helsinki for the ethical conduct of research involving human subjects. it was carried out from june till september 2023 sample size calculation: based on a pilot study, sample size was calculated according to the significant difference in the value of mean difference (pretreatments - post treatment values) of pain pressure algometer between progressive muscle relaxation exercises (2.01 ± 0.39) and pilates exercises (2.90 ± 0.24) groups in unpaired t test, with α=0.05, power of 80%, and an effect size of 0.74. so a sample size of 30 patients/per group would be required and increased to 35 women to allow for a 15% dropout rate (gpower 301 http:www.psycho.uni-duesseldorf.de) randomization of sample selection was achieved using closed envelop way. classification of the sample by simple random way into two groups equal in number, by using sixty closed envelop, each thirty envelop contained a name of a group from the two groups (group a) or (group b) and asking each woman to choose one envelop from them, each woman attended to the group according the name of the group written in her envelop. after randomization, they were divided into two groups equal in number

Eligibility criteria:
inclusion criteria: * ages were ranged from 25 to 35 years old and their body mass index (bmi) did not exceed 30kg/m2. they were postnatal by three months. the number of parity of all women was ranged from (1-3) times. exclusion criteria: * previous trauma to the spine, pelvis and lower limbs, * previous history of spinal surgery (such as spinal fusion surgery, vertebroplasty, or - --kyphoplasty), congenital spinal deformities, history of spinal tumors, ankylosing spondylitis, osteoporosis other spondyloarthritis

Keywords: progressive muscle relaxation exercises pilate's exercises low back pain. post natal period relaxation exercises
controling mean arterial pressure using a closed-loop system for vasopressor titration

Conditions: Cardiac Surgery

Summary: the investigators have developed an automated vasopressor controller to improve the titration of vasopressor in order to maintain mean arterial pressure (map) within a narrow range and have recently shown the controller was effective in both the operating room and intensive care unit. the controller has been used recently in a case series of three patients undergoing cardiac surgery and in five patients after cardiac surgery. the investigators want to compare now a manual to a closed-loop titration of vasopressor infusion in patients admitted in the intensive care unit after cardiac surgery

perioperative hypotension and arterial pressure variability have been shown to negatively impact patient outcomes, increasing risk of stroke, kidney injury, and myocardial injury among others. vasopressors are usually used to rapidly correct hypotension. vasopressor infusions are typically administered by standard infusion pump with the rate adjusted by anesthesiologists to reach a predefined target mean arterial pressure (map); this requires frequent changes in the infusion rate because of the almost constantly changing hemodynamic status of such patients. because it is infeasible for human providers to pay constant attention and make second-to-second changes, management is often suboptimal (i.e. large amounts of time are spent in hypotension below the target, or well above the target with the vasopressor drip still running). the investigators have developed an automated closed-loop vasopressor (clv) controller to improve the titration of vasopressor (e.g:noradrenaline) in order to maintain map within a narrow range in the perioperative setting. the investigators have published engineering, animal and most recently, pilot,studies or case series with promising results. in this randomized controlled trial, the investigators will compare time spent in hypotension defined as a mean arterial pressure \< 65 mmhg. they tested the hypothesis that the automated system will allow patients to spent less time during the postoperative period with a map \< 65 mmhg. this is thus a superiority study over a two hours study period

Eligibility criteria:
inclusion criteria: * adult patient * elective cardiac surgery * french speaking patient exclusion criteria: * uncontrolled hypertension * renal insufficiency (estimated glomerular filtration rate \< 30ml/min/1,73m²) * left ejection fraction \< 40% * emergency surgery * preoperative infection * preoperative cardiac arrythmia * pregnant women
medical record study on adverse events requiring a higher level of care in flemish hospitals

Conditions: Sepsis, Cancer, Heart Attack, Heart Failure, Abdominal Surgery, Trauma, Diabetes, Lung Disease, Gynaecology, Fertility, Cardiac Surgery,

Summary: an adverse event (ae) is defined as unintended injury or complication, which results in disability, death or prolongation of hospital stay, and is caused by healthcare management (including omissions) rather than the patient's disease. retrospective record reviews in several countries have shown that 2,9% to 16,6% of patients in acute hospitals experience one or more aes. a patient with an ae may require a higher level of care. although all aes are important, preventable aes that result in an upgraded level of patient care are of particular concern. in this study it's defined as an unplanned admission to intensive care unit (icu) or a mobile emergency team (met) intervention. the objectives of this study are to determine the incidence of (preventable) adverse events requiring icu admission or met intervention and to assess the level of harm of each ae.


Eligibility criteria:
inclusion criteria: * all patients being transferred to a higher level of care during the study period (november 2011 - may 2012) * in practice, the higher level of care means * (1) (re)admission to the intensive care unit from other care units in the hospital providing lower intensity care, * (2) to an intervention by a medical emergency team due to an unanticipated change in the patient's clinical status exclusion criteria: -

Keywords: adverse events unplanned admission intensive care chart review
inversion and fixation of the transversalis fascia in laparoscopic inguinal hernia repair

Conditions: Hernia, Inguinal

Summary: according to the ehs classification, at least 80 patients who will undergo tep repair for the first time with the diagnosis of m2 and m3 direct inguinal hernia will be randomized into 2 groups. after direct hernia reduction in the patients in the first group, the transversalis fascia at the hernia site will be pulled inward and fixed to the cooper ligament with 2 or 3 absorbable tackers. standard surgery will then be continued. the patients in the second group will undergo standard surgery without any seroma prevention procedure. demographic data, clinical/radiological seroma rate, postoperative pain (vas values),quality of life(sf36 questionnaire), recurrence and other complications at postoperative 1st, 7th day, 3rd and 6th month will be monitored. when the desired number of patients and the follow-up period are reached, the data in the 2 groups will be compared.


Eligibility criteria:
inclusion criteria: * clinical or/and radiological diagnosis of primary inguinal hernia * ehs type m2 and m3 direct hernias * laparoscopic totally extraperitoneal (tep) repair exclusion criteria: * indirect hernias * m1 direct hernias * recurrent hernias * patients with previous groin operations on same side * pregnant women * patients who did not accept to participate in the study * asa score of 3 or higher,

Keywords: inguinal hernia tep seroma laparoscopic hernia transversalis fascia inversion
humeral shaft fractures : outcomes of straight percutaneous intramedullary nailing with dynamic distal locking

Conditions: COVID-19; Coronavirus Infections; Seroprevalence; Vaccination; Health Care Workers

Summary: this study looks at how many healthcare workers at chsd have developed antibodies against covid-19 after the second and third waves of the pandemic and following vaccination. by testing blood samples, we want to understand how well healthcare workers are protected, which work areas might be more at risk, and how immunity changes over time after infection or vaccination.


Eligibility criteria:
inclusion criteria: * patients operated between january 2008 and june 2018 * closed, isolated, displaced fractures of the humeral shaft * treatment by percutaneous anterograde intramedullary nailing with dynamic distal locking * availability for follow-up and evaluation (e.g., constant score assessment in june 2018) exclusion criteria: * open fractures * fractures that are not isolated or not displaced * patients lost to follow-up at the june 2018 evaluation (18 excluded) * lack of constant score evaluation (patients not reviewed)
espb vs ipack+acb in total knee arthroplasty

Conditions: Knee Arthritis; Knee Arthropathy; Knee Osteoarthritis; Knee Pain Chronic; Knee Disease; Knee Rheumatism

Summary: effect of ipack block with adductor canal block and espb on pain management, and nlr and plr following knee arthroplasty

knee arthroplasty is one of the most common orthopaedic procedures, especially in elderly patients, due to the deformation of joints. patients may complain of severe pain due to surgical trauma and prostheses. regional anaesthesia methods may be performed to reduce the surgery's induced stress response, opioid consumption, and opioid-related side effects. in recent years, the influence of regional anesthesiology on reducing the inflammatory response after surgical procedures has been emphasised. however, very few studies have evaluated the effect of various methods of anaesthesia on the nlr and plr. this is the first study to investigate the effect of regional anaesthesia on the pain managementonse expres and stress respsed by the nlr and plr in patients undergoing knee replacement surgery.

Eligibility criteria:
inclusion criteria: * patients with asa classification i-iii, aged 20-90 years, who will be scheduled for knee arthroplasty under spinal anaesthesia. exclusion criteria: * patients who have a history of bleeding diathesis, * take anticoagulant therapy, * have a history of chronic pain before surgery, * have multiple trauma, cannot assess their pain (dementia), * have been operated on under general anaesthesia, * have an infection in the area and do not accept the procedure
evaluation of pupillometry for cyp2d6 phenotyping in children treated with tramadol

Conditions: Drug Intolerance; Cytochrome P450 CYP2D6 Enzyme Deficiency; Drug Effect

Summary: pupillometry will be performed before administration of tramadol, at t0 and then 1 to twice per hour in children having received tramadol as a pain killer as part of his/her routine care. pupillometry measurement will be correlate to cyp2d6 phenotype and cyp2d6 genetic score

the proposed study is a single-center, observational and prospective study which will be conducted at the pediatric emergency department, geneva children's hospital. this study will begin in january 2016 and will last one year. 53 patients are planned to be enrolled. children receiving oral tramadol as a pain killer at the emergency department, as part of their routine care, will be informed of the current study. patients willing to participate will be included in the study after signing the inform consent (or respectively his/her parents or legal guardians). a unique oral dose of dextromethorphan (0.15 mg/kg) will be given to the participant for cyp2d6 phenotyping (t0). two hours later, capillary whole blood will be sampled to 1) measure the metabolic ratio dextrorphan/dextromethorphan (mrdor/dem) in order to determine cyp2d6 phenotype (validated metrics for cyp2d6 phenotyping), 2) measure tramadol and its active metabolite o-desmethyltramadol (m1), and 3) to genotype for cyp2d6. saliva sample will also be performed to genotype for cyp2d6. pupillometry will be performed before administration of tramadol, at t0 and then 1 to twice per hour, throughout the patient's stay at the emergency department.

Eligibility criteria:
inclusion criteria * age 1-15 year at time of inclusion * weight ≥ 10 kg * treatment with tramadol as a pain killer administrated as part of their routine care * parent/legal guardian has been informed about the study and has signed informed consent form exclusion criteria * known kidney or liver disease * concomitant treatment with inhibitors/inducers of cyp2d6 and cyp3a * documented previous adverse reaction to tramadol or dextromethorphan * concomitant treatment with any opiate drug and/or any drug with a known impact on pupil size * any concomitant condition, which in the opinion of the investigator would preclude a subject's participation in the study

Keywords: children pain cytochrome p450 cyp2d6 genotype cytochrome p450 cyp2d6 phenotype pupillometry
efficacy and safety study of rt001 for the treatment of moderate to severe lateral canthal lines in adults

Conditions: Lateral Canthal Lines; Crow's Feet; Facial Wrinkles

Summary: the purpose of this study is to find out if an investigational drug, called rt001 botulinum toxin type a topical gel, is safe and useful in minimizing the wrinkles between the eye and hairline called crow's feet, also known as lateral canthal lines.

rt001, a new drug, may be effective for the temporary improvement in the appearance of moderate to severe lateral canthal lines (crow's feet wrinkles) in adults. in this study, researchers want to find out if rt001is more effective than placebo gel by examining the effect on the improvement of crow's feet by both the patient and physician.

Eligibility criteria:
inclusion criteria: * written informed consent including authorization to release health information * female or male, 18 to 65 years of age and in good general health * willing and able to follow study instructions and likely to complete all study requirements * moderate to severe lateral canthal lines (crow's feet wrinkles) exclusion criteria: * any neurological condition that may place the subject at increased risk with exposure to botulinum toxin type a, including peripheral motor neuropathic diseases such as amyotrophic lateral sclerosis and motor neuropathy, and neuromuscular junctional disorders such as lambert-eaton syndrome and myasthenia gravis * muscle weakness or paralysis, particularly in the area receiving study treatment * active disease or irritation at the treatment areas including the eye and the skin * pregnant, nursing, or planning a pregnancy during the study; or is a woman of childbearing potential (wocbp) but is not willing to use an effective method of birth control * previous participation in a rt001 clinical study

Keywords: lateral canthal lines crow's feet wrinkles facial wrinkles
pain with dementia

Conditions: Pain; Dementia, Mild; Dementia, Moderate

Summary: the purpose of the study is to develop a caregiver-assisted pain coping skills training program for older adults who have pain and mild to moderate dementia and are living at home with a family caregiver. the investigators are planning to recruit 30 patient-caregiver dyads (60 individuals).

involving caregivers in a pain coping skills protocol is likely to optimize treatment outcomes in several ways. first, people with dementia (pwd) are likely to have difficulty learning and remembering pain coping skills; training the caregiver to coach the patient in the use of the skills is likely to improve the patients' acquisition and ongoing use of learned skills. second, caregiver involvement in pain coping skills training may increase their understanding of how to gauge how much pain the pwd is experiencing and the impact of pain management strategies. this understanding is increasingly important as the patient's disease progresses, and s/he is less able to report pain verbally. third, caregiver-assisted pain management training may enhance caregivers' self-confidence for managing the patient's pain. finally, by participating in the pain coping skills training protocol, caregivers may learn coping skills (such as relaxation) that can help them manage the stress associated with caring for a pwd and pain which can be significant.

Eligibility criteria:
inclusion criteria: patients: * mild or moderate dementia * pain on most days for at least 3 months that interferes with function * living at home (non-institutional) * age ≥ 50 * english speaking caregivers: * provides on average at least 4 hours/day of care/assistance to the patient * age ≥ 18 * english speaking exclusion criteria: patient and caregivers * lacking capacity for interview or unable to provide informed consent/assent. * visual or hearing impairments or severe behavioral problems that preclude participation. * too sick to participate.
the effect of shuhua milk fortified with plant sterol esters on serum cholesterol in human

Conditions: Hypercholesterolemia

Summary: the purpose of this study is to determine whether yili xinhuo shuhua milk is effective in reducing the serum cholesterol in human with hypercholesterolemia.

in a randomized, placebo-controlled double-blind mono-centric study,179 subjects with total cholesterol (tc) level above 5.18mmol/l and triglyceride (tg) level lower than 2.25mmol/l were assigned to 500ml of low lactose milk enriched with 1.58g plant sterol esters or 500ml plain milk without plant sterols (placebo) or without any dairy product consumption (control) for 60 days. subjects were instructed to maintain stable diet pattern and physical activity. plasma concentrations of tc,tg,ldl cholesterol(ldl-c) and hdl cholesterol(hdl-c) were measured at initial visits, after 30days and after 60 days. the primary measurement was the change in tc. secondary measurements were changes in tg,ldl-c and hdl-c.

Eligibility criteria:
inclusion criteria: * male or female subjects, 18-65 yrs; * serum tc ≥5.18mmol/l, and tg≤2.25mmol/l; * normal blood pressure or able to control blood pressure within normal range; * willing to consent to study participation and to comply with study requirements. exclusion criteria: * pregnant or breastfeeding women; * known allergies to dairy and any substance in the study product.for example lactose intolerance; * any comorbidity that could,in the opinion of the investigator, preclude the subject's ability to successfully and safely complete the study or that may confound study outcomes, including but not limited to cardiac disease, hepatic disease, renal disease, hematopoietic system disease and mental disease; * recent use (within 2 weeks of screening) of any prescription or otc medication that affects serum total cholesterol or that may confound study outcomes.

Keywords: shuhua milk plant sterol esters serum cholesterol human
family help program: pediatric recurrent headache and abdominal pain

Conditions: Pediatric Recurrent Headache & Abdominal Pain

Summary: the purpose of the strongest families (formerly family help program)is to evaluate the effectiveness of the strongest families distance intervention compared to usual or standard care that is typically provided to children with mild to moderate recurrent headache/abdominal pain symptomology. this is a single-centre trial based at the iwk health centre. the primary outcome is change in diagnosis.

the purpose of the family help program is to deliver, primary care mental health services to children and their families in the comfort and privacy of their own home. approximately 106 children (9-12 years of age)suffering from mild to moderate (but clinically significant) symptoms of pediatric recurrent headache/abdominal pain will be randomized. the intervention is delivered from a distance, using educational materials (manuals, video-tapes, audio-tapes) and telephone consultation with a trained paraprofessional "coach" who is supervised by a licensed health care professional. the telephone coach delivers consistent care based on written protocols, with on-going evaluation by a professional team. fifty percent of the eligible participants will receive family help program telephone-based treatment and 50% will be referred back to their family physician to receive standard care as determined by that physician. those receiving standard care will be evaluated for outcome results and then compared to the family help treated participants. it is anticipated that family help treatment will be proven to be as or more effective than standard care.

Eligibility criteria:
inclusion criteria: * child 9 to 16 years of age * child had recurrent headache and abdominal pain at least 3 times a month * child's physical examination normal * access to a telephone in the home * speak and write english * mild to moderate anxiety symptomology exclusion criteria: * child's pain due to trauma, systemic disease or disorder * child received any psychological treatment for this or similar disorder in the past 6 months
synbiotics cohort study

Conditions: Cows Milk Allergy

Summary: observational study exploring the clinical outcomes of infants with cow's milk allergy who are prescribed a hypoallergenic formula containing synbiotics.

a range of clinical outcomes will be collected from the medical records and in-person assessment of 60 fully or partially formula fed infants (aged \<13 months) who are prescribed a hypoallergenic formula containing synbiotics as part of usual clinical practice for the dietary management of cow's milk allergy

Eligibility criteria:
inclusion criteria: * aged \<13 months * confirmed or suspected cma- based on healthcare professional (hcp) judgement * at baseline, parent(s) must already be exclusively or partially formula feeding their child (with a hypoallergenic or non-hypoallergenic formula) or have already made the decision to start exclusively or partially formula feeding * recently prescribed a hypoallergenic formula containing synbiotics exclusion criteria: * exclusively breastfed infants * primary lactose intolerance * enterally fed infants * premature infants (born \<37 weeks) with a corrected age of less than 1 month * infants with contraindications to the use of hyopallergenic formula containing synbiotics * major hepatic or renal dysfunction * investigator concern around the ability of family to comply with protocol and requirements of study

Keywords: synbiotics paediatrics gut microbiome