Kornimate/medical-research-clean huggingface dataset:
correlation between visual field defects on foresee preferential hyperacuity perimeter(php) and on optical coherence tomography (oct) in patients with choroidal neovascularization (cnv)

Conditions: Age Related Macular Degeneration

Summary: study come to investigate the correlation between visual fields (vf) defects map generated by preferential hyperacuity perimeter (php) and features of the choroidal neovascular lesions (cnv) demonstrated by optical coherence tomography(oct). to investigate the foresee php ability to asses treatment progression post treatment.

the foresee php is used in the recent years to detect age-related macular degeneration (amd) lesions. the device is capable of differentiation as to stages of amd and early detection of changes including choroidal neovascularization (cnv) the foresee php™ demonstrates a high level of sensitivity and specificity as to the different stages of amd including newly diagnosed or early detection of cnv. the oct may be use as well to identify choroidal neovascularization (cnv). comparison between the two methods will allow better understanding of both devices. the foresee php can use as an assessment tool for the progression and success of the treatment given to amd lesions. therefore, evaluation the size and the location of the treated lesions may serve as an additional tool.

Eligibility criteria:
inclusion criteria: * capable and willing to sign a consent form and participate in the study * subjects diagnosed as new cnv or treated cnv * age \>50 years * va with habitual correction \<20/160 in the study eye * ability to understand instructions exclusion criteria: * evidence of macular disease other than amd or glaucoma in the study eye * presence of any significant media opacity that precludes a clear view of the macular area as identified in the study eye by biomicroscopy, * any non-macular related ocular surgery performed within 3 months prior to study entry in the target eye * patients diagnosed with geographic atrophy (ga) * participation in another study with the exclusion of areds study

Keywords: amd
influence of the covid-19 epidemic on stress

Conditions: Stress, Psychological

Summary: the coronavirus has a major influence on stress for the general population. however, data are currently non-existent concerning the perception and knowledge of the epidemic, the feeling of information from companies / establishments / governments, the means of protection used, the feelings of fear generated and their impact on feelings of stigmatization towards certain ethnic groups or categories of patients (those who cough ...), or relationships with socio-demographic factors or lifestyle.

this is an observational study using a redcap® questionnaire via an internet link, which will be distributed by any means (facebook, twitter, institution mailing lists via a referent, flash codes distributed to patients and the public, etc.). the self-questionnaire will assess stress, perception and knowledge of the epidemic, the feeling of information on the part of businesses / establishments / governments, the means of protection used the feelings of fear generated and their impact on feelings of stigmatization towards certain ethnic groups or categories of patients (those who cough ...), or relationships with socio-demographic factors or lifestyle.

Eligibility criteria:
inclusion criteria: * anyone volunteer to participate exclusion criteria: * anyone non-voluntary to participate

Keywords: stress, psychological coronavirus epidemics
village-integrated eye worker trial ii - pilot

Conditions: Cataract; Glaucoma; Age Related Macular Degeneration; Diabetic Retinopathy; Refractive Errors

Summary: the vast majority of blindness is avoidable. the world health organization (who) estimates that 80% of cases of visual impairment could be prevented or reversed with early diagnosis and treatment. the leading causes of visual impairment are cataract and refractive error, followed by glaucoma, age-related macular degeneration (amd), and diabetic retinopathy (dr). loss of vision from these conditions is not inevitable; however, identifying at-risk cases and linking cases with appropriate care remain significant challenges. worldwide, eye health care systems must determine optimal strategies for reaching people outside of their immediate orbit in order to reduce visual impairment. visual impairment can be reduced by case detection of prevalent disease like cataract and refractive error, or by screening for early disease like glaucoma, amd, and dr and preventing progression. systems around the world have developed numerous approaches to both case detection and screening but there is very little research to support the choice of allocating resources to case detection or screening and little data exists on the cost effectiveness of the various approaches to each. view ii pilot is a cluster-randomized trial to determine the effectiveness of different approaches to community-based case detection and screening for ocular disease. communities in nepal will be randomized to one of four arms: 1) a comprehensive ocular screening program, 2) a cataract camp-based program, 3) a community health worker-based program, and 4) no program.

specific aim 1: to determine whether screening leads to increased visual acuity compared to the cataract camp approach. specific aim 2: to determine whether a community health volunteer program increases the rate of cataract surgery compared to a no program.

Eligibility criteria:
inclusion criteria(community-level): * wards in the chitwan and nawalparasi districts that participated in the view trial and have not received a cataract camp in the past 6 months. inclusion criteria (individual-level): * individuals aged 50 and older will be eligible to participate in the screening program, cataract camp programs, and the fchv program
cerebral activation and bilateral stimulation by cochlear implantation in bilateral deaf adults

Conditions: Deafness

Summary: the primary objective to this study is to describe bilateral auditory information processing in profoundly deaf patients with bilateral cochlear implants compared with normal hearing patients. assumption used is that due to the central consequences of bilateral deafness on binaural auditory information central processing, time between activation of the two cochlear implants is a decisive factor in bilateral implantation compared to unilateral implantation


Eligibility criteria:
inclusion criteria for patients: - profoundly deaf patients with bilateral cochlear implants exclusion criteria for patients: * post-operative complications * incomplete surgical insertion of one of the cochlear implant * age under 18 years * non-compliant patient * pregnant woman or woman with no efficient contraception method * informed consent not signed * no health insurance inclusion criteria for control - normal hearing subjects exclusion criteria control * normal hearing subject * subject under 18 years old * unilateral or bilateral hearing loss * non-compliant subject * pregnant woman or woman with no efficient contraception method * informed consent not signed * no health insurance
the role of vitamin d supplementation on pain in women with primary dysmenorrhea and hypovitaminosis d

Conditions: Hypovitaminosis D

Summary: the purpose of this study is to evaluate the effect of vitamin d supplementation on the pain score of primary dysmenorrhea. our hypothesis is that by normalizing vitamin d level could help improve pain score of women who have primary dysmenorrhea.

this study is aimed to be conducted in randomised controlled trial, comparing between intervention group and placebo group. we include women with primary dysmenorrhea who also have low vitamin d level in this trial. our primary outcome is to compare visual analog pain scale between intervention and placebo group after treatment. after randomised and allocated, these women will be given vitamin d 50,000 iu or placebo capsules orally weekly for 8 consecutive weeks. we monitor pain score daily from the cycle before the drugs started until complete 8-week course of the regimen mentioned. also vitamin d levels will be monitored twice, one before treatment and the other after treatment.

Eligibility criteria:
inclusion criteria: * primary dysmenorrhea * hypovitaminosis d exclusion criteria: * using calcium, magnesium or phosphorus in the past 3 months * using hormonal contraception or iud in the past 6 months * no smoking or alcohol drinking * chronic underlying diseases * allergic to components in study drugs
technology enhanced behavioral activation treatment for substance use

Conditions: Substance-Related Disorders; Depressive Disorder; Behavioral Symptoms; Risk-Taking; Sexual Behavior

Summary: the purpose of this study is to: 1. test the effect of a smartphone enhanced lets act (lets act-se) on frequency of substance use 2. use functional magnetic resonance imaging (fmri) to test the relationship between neuromarkers of reward sensitivity on frequency of substance use.

comorbid substance use disorder (sud) and depression is highly prevalent and associated with elevated rates of post treatment relapse to substance use, hiv risk behavior, and associated poor mental and physical health outcomes. further, rates of substance use and depression disproportionately affect minority groups and those living in poverty. although efficacious, the often complex, specialized nature of cbt poses problems in its integration into substance use treatment programs. budget cuts for mental health and substance use treatment both nationally and in the state of north carolina, reduce availability of publically funded treatment programs and staff to patient ratios. to address this limitation, a behavioral activation (ba) treatment, the life enhancement treatment for substance use (lets act), was developed to treat depressive symptoms among a predominantly african american sample of low income illicit drug users currently receiving residential substance use treatment. collectively, two stage i studies and 1 year follow-up data from the investigators stage ii r01da026424 indicate that compared to a control condition, lets act is associated with significantly better outcomes for treatment retention, post treatment abstinence, hiv sexual risk behavior, depressive symptoms, and environmental reward. although these strong outcomes suggest that lets act may be ready for a stage iii dissemination trial, it is of note that there was a significant indirect effect of lets act homework compliance on post treatment substance use and hiv sexual risk behavior via the theoretically proposed ba mechanism of action, environmental reward. in the context of limited access to care, these findings point to the need to identify cost-effective delivery-vehicles to increase treatment engagement outside of clinician sessions. further, identifying neuroscience based biomarkers (neuromarkers) underlying key theoretical aspects of ba (i.e., reward sensitivity), and their relation to heterogeneity in ba treatment response among substance users with depression, are critical for the identification of accurately targeted interventions.

Eligibility criteria:
inclusion criteria: * between 18 and 55 * meet criteria for dsm-v substance use disorder * elevated depressive symptoms (bdi ≥ 14) exclusion criteria: * limited mental competency (mmse \< 23) * psychosis * the use of psychotropic medication for \< 3 months * the inability to give informed, voluntary, written consent to participate

Keywords: mental disorders mood disorders behavioral activation
the effects of tdcs combined with balance training on lower limbs spasticity in chronic stroke patients

Conditions: Ischemic Stroke

Summary: spasticity is one of the most common disorders in patients with central nervous system diseases such as stroke. transcranial direct current stimulation stimulation (tdcs) is a noninvasive tool that can be used to modulate cortical excitability of the leg motor area, and the spinal motor circuits as well. objective:the objectives of this study is to examine the efficacy of anodal tdcs combined with biodex balance training on lower limbs spasticity in chronic stroke patients using laboratory and clinical assessments.

in a randomized, sham-controlled, double-blinded clinical study, hemiplegic chronic stroke patients are randomized to receive active tdcs delivered to lesioned leg motor cortex (cz) or sham combined with balance training with biodex balance system. experimental group receive tdcs stimulation (2ma) for 20 min, 5 sessions in five days paired with 20 min balance training.

Eligibility criteria:
inclusion criteria: * age ≥18 years; * first-ever ischemic stroke; * chronic phase of recovery (\>6 months); * ability to walk 6- meter supported or unsupported; * ability to stand at least unsupported for 40-seconds with eyes closed; * only ischemic stroke involving middle cerebral artery (mca) territory confirmed by ct or mri. exclusion criteria: * use of any neuro- or psycho-active medications that alters balance; * any other neurological conditions or sensory disorders affecting postural control; such as brain tumor, or substance abuse; orthopedic diseases; * ongoing/recent (within 3 months) balance rehabilitation.

Keywords: tdcs stroke spasticity
an oral nutritional supplement study in older malnourished spanish population

Conditions: Malnutrition

Summary: post-marketing observational study of a nutritional care plan, including a higher calorie, higher protein oral nutritional supplement (ons), prescribed to spanish patients, both free living and residing and nursing homes, who have been identified as malnourished. the objective is to assess the impact of the ons on body weight, activities of daily living and quality of life.


Eligibility criteria:
inclusion criteria: * voluntarily signed and dated an informed consent form (icf), approved by an independent ethics committee (iec)/institutional review board (irb), prior to any participation in the study. * considered malnourished, or is at risk for malnutrition based on nrs 2002 score ≥3. * ≥65 years of age. * conforms to the requirements set forth on the study product label. * under the care of a health care professional for malnutrition and has recently (within the last 7 days prior to participating in this study) been prescribed 2 servings/d of the study ons, orally, by their health care professional. * free living or residing in a nursing home. * estimated, or measured, glomerular filtration rate \>60ml/min/1.73m2 (modification of diet in renal disease (mdrd) study equation) within 60 days of beginning their nutritional care plan. * body mass index (bmi) is \<30 kg/m2. * study physician determines the subject is fit to participate.
conservative management in patients diagnosed with grade 2 or grade 3 cin

Conditions: High-Grade Squamous Intraepithelial Lesions; Neoplasm Regression, Spontaneous; Disease Progression; Papillomavirus Infections

Summary: consecutive inclusion and collection of information for all women attending the cervical disease unit with an histological diagnosis of grade 2 or grade 3 cin during the last 5 years, from january 2012 to december 2016, which meet the inclusion criteria, have voluntarily manifested pregnancy intendedness and had a minimum follow-up time of 2 years and a maximum of 7. the aim is to evaluate whether the hsil resolution rates (cin 2 or cin 3) are sufficient to support conservative management.

follow-up is performed every 4 months with colposcopy, cytology and biopsies. colposcopy and cytology are performed for all control subjects. the need for biopsy is established according to the colposcopy exam findings to confirm h-sil or cervical cancer. follow-up is spaced every 6 months if the cytology and biopsy results indicate l-sil / ascus in agreement with the colposcopic image. hpv tests are performed every 8-12 months. this strategy is maintained until the resolution of the h-sil. the conservative management stops if the h-sil lesion persists after 24 months of follow-up, if the inclusion criteria are no longer met or if the exclusion ones are met. inclusion and exclusion criteria are reviewed at each visit and the conservative management ceases in case the patient decides to undergo conization.

Eligibility criteria:
inclusion criteria: * reproductive age and willing to get pregnant in the future * acceptance of conservative management * commitment to study visits. * colposcopy with zone of transformation (zt) type 1 or 2 (unio esco-columnar totally visible) with image compatible with h-sil and visible in its entirety. exclusion criteria: * pregnant women * immunosuppression for human immunodeficiency virus (hiv) or iatrogenic type * suspicion or diagnosis of glandular cell atipia (acg), adenocarcinoma in situ (ais) or cervical cancer (cc) * provided that inclusion criteria are not met
efficacy and safety of ledipasvir/sofosbuvir fixed-dose combination for 8 weeks in subjects with chronic genotype 1 hcv and hiv-1 co-infection

Conditions: Treatment of Hepatitis C

Summary: target population: hepatitis c treatment naïve, non-cirrhotic, chronic genotype 1 hepatitis c virus (hcv) infected adults that are co-infected with human immunodeficiency virus (hiv)-1and have hcv rna \< 6 x106 iu/ml duration of subjects will be treated for 8 weeks and followed for 24 weeks post- treatment: treatment


Eligibility criteria:
inclusion criteria: * chronic hcv gt1, treatment-naïve, non-cirrhotic adult subjects. * hcv rna levels more than 10,000 iu/ml and less than 6,000,000 iu/ml at screening exclusion criteria: * gastrointestinal disorder or post-operative condition that could interfere with the absorption of the study drug. * solid organ transplantation. * significant cardiac disease or other significant co-morbidities that could interfere with study treatment. * malignancy within the 3 years prior to screening, with the exception of specific cancers that have been cured by surgical resection (basal cell skin cancer, etc.). subjects under evaluation for possible malignancy are not eligible. * infection with hepatitis b virus (hbv)
donation advisor clinical decision support tool study

Conditions: Organ Donation

Summary: every year, thousands of canadians receive life-saving, cost-effective organ transplants, while thousands more still wait or die because not enough organs are available. patients with non-recoverable illnesses, who are undergoing withdrawal of life sustaining measures, can donate their organs when they die by a process called donation after circulatory determined death (dcd). however, over 30% of all dcd attempts are unsuccessful because patients do not die within the time frame required for healthy organ retrieval and prolonged exposure to low oxygen during the dying process renders organs unsuitable for transplantation. predicting successful dcd is difficult and leads to uncertainty in the clinical community. to address this issue, the investigators have developed a clinical decision support tool called donation advisor (da) that will assist the healthcare team in identifying successful dcd donors and will provide an improved assessment of the health of their organs. the investigators are ready to implement da and evaluate its impact in 7 hospitals in ontario. the investigators believe use of da will reduce unsuccessful dcd attempts, enhance family experience of donation, optimize system costs, and improve transplant outcomes


Eligibility criteria:
inclusion criteria * for organ donation patients: all patients eligible for dcd and whose substitute decision makers (sdms) have been approached for consent by a trillium organ tissue donation coordinator (otdc). * for organ transplant recipient patients - all patients at any of the transplant centres participating in this study who are transplant recipients of the organs from enrolled donor patients. * for health care professionals for interviews to provide feedback on the donation advisor tool - all physicians (donation and transplantation), bedside nurses and otdcs who either have the potential to be involved in the care of study patients, or who been directly involved in the care of the study patients. exclusion criteria * none

Keywords: organ donation after circulatory determined death (dcd) clinical decision support tool organ donation organ transplantation dcd
pharmacokinetics of single bolus dose of novoseven® in paediatric and adult patients with haemophilia a or b in a non- bleeding state

Conditions: Congenital Bleeding Disorder; Haemophilia A; Haemophilia B

Summary: this trial is conducted in europe. the aim of this trial is to determine the pharmacokinetics of activated recombinant human factor vii (novoseven®) in haemophiliac patients in a non-bleeding state.


Eligibility criteria:
inclusion criteria: * age 18-55 years and congenital haemophilia a or b male with severe fviii or fx deficiency +/-inhibitors * age between 3-12 years and congenital haemophilia a or b male with record of inhibitors exclusion criteria: * known hypersensitivity to activated recombinant human factor vii or any of its components * known clinical relevant coagulation diseases or insufficiencies other than congenital haemophilia * clinical manifestation of hiv (human immunodeficiency virus) and/or protease inhibitor treatment * clinical manifestation of active/recent bleeding * administration of coagulation factor preparations within 24 hours of novoseven trial product dose administration * body mass index (bmi) outside normal range * known abuse of elicit drugs and/or alcohol * renal insufficiency * hepatic disease * cardiovascular disease * any disease or condition which, judged by the investigator, could imply a potential hazard to the patient, interfere with the trial participation or trial outcome
symax international study

Conditions: Hip Osteoarthritis; Prosthesis Durability

Summary: the uncemented symax hip stem is developed through optimization of the uncemented omnifit hip stem. the symax stem design combines an anatomical anteverted proximal geometry with a straight distal section. the proximal part is coated with a biomimetic hydroxyapatite (ha) coating for improved osseointegration to enhance load transfer and to minimize proximal bone loss. the distal part is treated with an anodization surface treatment in order to prevent distal bone apposition, which is expected to prevent distal loading and reduce proximal stress shielding. aim of this study is to report mid-term clinical performance and evaluate whether the radiographic features are in line with the design principles of the symax hip in an international clinical study with 5 years of follow-up.


Eligibility criteria:
inclusion criteria: * patients requiring uncemented primary total hip arthroplasty (osteoarthritis, avascular necrosis and/or post-traumatic arthritis), age between 18-70 years, bmi less or equal to 35. exclusion criteria: * patients with bilateral hip complaints, impaired cognitive function and use of medication or illness influencing bone metabolism.
contrast enhanced mri of the cns - patients with known cerebral neoplastic lesions.

Conditions: Neoplastic CNS Lesions

Summary: study to compare of two contrast agents in imaging brain lesions.


Eligibility criteria:
inclusion criteria: * known neoplastic cns lesions

Keywords: neoplastic cns lesions contrast enhanced mri comparison
magnetic resonance (mr) in asthmatic patients

Conditions: Asthma

Summary: asthma is a disease of small airways. affected areas have reduced lung ventilation causing reflex vasoconstriction. mr perfusion imaging of the lungs is a sensitive method of imaging zonal lung perfusion.

a cohort of 70 asthmatic patients and 10 controls, both sets of subjects have hrct, mri/a of the thorax, and pulmonary function tests to correlate the degree of pulmonary dysfunction with findings on imaging tests.

Eligibility criteria:
inclusion criteria: * all asthmatic patients are eligible. exclusion criteria: * patients in whom mri is contraindicated