Kornimate/medical-research-clean huggingface dataset:
evaluation of telerehabilitation following inpatient or outpatient rehabilitation phase ii

Conditions: Oncology; Musculoskeletal Diseases

Summary: telerehabilitation is implemented in the pensionsversicherungsanstalt (pva) as an independent rehabilitation offer following a rehabilitation phase ii. this offer primarily includes physiotherapeutic training units in group settings and in individual counselling, as well as health-related educational sessions and doctor's consultations via video conferencing, initially for rehabilitation patients with diseases of the musculoskeletal system or oncological diseases. the first stage of the implementation process was evaluated with a focus on acceptance, usability and feasibility from the perspective of patients and treatment team. the evaluation was based on a convergent mixed methods design (creswell \& plano clark, 2017) to draw on the strengths of qualitative and quantitative research approaches (creswell \& creswell, 2018). qualitative and quantitative data were generated in parallel and treated equally. the perspective of the patients (n = 86) was collected through online questionnaires and in-depth telephone interviews (n = 22) and that of the treatment team through a questionnaire survey (n = 32) and focus group interviews (n = 24). the administrative team (n = 8) was asked for their assessment in a focus group interview. technical difficulties in the implementation of telerehabilitation were documented by the treatment team. the consolidation of these multi-perspective results took place at the level of interpretation.


Eligibility criteria:
inclusion criteria: patients who have completed rehabilitation (phase ii) with the indications: * musculoskeletal diseases * oncology. exclusion criteria: * failure to obtain the declaration of consent * lack of the required technical aids (mobile phone, tablet or pc) * lack of the technical skills to operate the app and thus to participate in telerehabilitation.

Keywords: telerehabilitation evaluation usability
mri 3d ute hyper-cones & zte for pet/mr lung attenuation correction & for lung diagnostic imaging

Conditions: Lung Diseases

Summary: mri 3d ute hyper-cones \& zte for pet/mr lung attenuation correction \& for lung diagnostic imaging

the primary objective is to clinically test the feasibility of 3d ute hyper-cones \& zte in capturing lung density of patients with lung diseases at reasonable clinical imaging times compared to standard mr lung protocols (lava-flex, propeller). secondly, we want to investigate if hyper-cones \& zte can be used for lung imaging such as vessels and air-pathways, oncological patients, lung nodules and lung infiltration \& parenchyma pathophysiology such as chronic obstructive pulmonary disease.

Eligibility criteria:
inclusion criteria: * informed consent and signature * clinical pet/ct planned and performed at wagi site in schlieren * male or female patients * from 18 to 80 years of age. exclusion criteria: - same exclusion criteria as for the clinical pet/ct exam (i.e. pregnant women). additional exclusion criteria: - standard exclusion criteria for clinical mri (evaluated by clinical standard determined by mri questionnaire).
french validation of axial spondyloarthritis questionnaires (val-spa)

Conditions: Axial Spondyloarthritis; Ankylosing Spondylitis

Summary: the aim is to do a french linguistic validation of three questionnaires used in axial spondyloarthritis (basfi, bas-g, dougados functional index). in order to validate the questionnaires, a prospective, qualitative, observational and monocentric study will be conducted.

axial spondyloarthritis (spa) is a chronic rheumatic diseases affecting axial skeleton and sacro-iliac joints. spa can have functional consequences, often assessed with the bath ankylosing spondylitis functional index (basfi), the dougados functional index, or more globally with the bath ankylosing spondylitis global (bas-g). if these questionnaires are validated in english, there are not validated in french. the aim is to do a french linguistic validation of these questionnaires. a translation, reconciliation and retro-translation will be conducted for each of the questionnaires by two bilingual translators. the last version of each questionnaire will be then validated by clinicians experts in spa. the version will be further validated by 5 patients. if necessary and if changes occured on the version of the questionnaire, another version will be validated by 5 other patients until full understanding is obtained.

Eligibility criteria:
inclusion criteria: * patients diagnosed with axial spondyloarthritis or ankylosing spondylitis exclusion criteria: * patients who do not understand french * patients with cognitive impairments * people protected by law * people who do not want to participate

Keywords: validation basfi dougados functional index bas-g
microbiome sampling during endurance exercise

Conditions: Healthy; Exercise-Induced Lactic Acidemia

Summary: the small intestine and feces of subjects undergoing endurance exercise will be sampled to examine their microbiome composition

the close relationship between humans and the commensal microbes of their gut microbiota represents vast potential for health maintenance, but most efforts have been focused on disease. gastrointestinal (gi) problems are very common especially in endurance athletes, and are known to impair performance or subsequent recovery. moreover, gi symptoms among athletes vary enormously, and some athletes are more prone than others; the links between this variation and the differences in microbiome composition across individuals have not been elucidated. the investigators propose to use a novel, non-invasive sampling technology to quantify the effects of exercise on the gi environment including the small intestines, and aim to establish the potential for dietary interventions to improve recovery from exercise.

Eligibility criteria:
inclusion criteria: subjects must meet all of the following criteria to be included in the study: * males or females 18 years of age or older and 70 years of age or younger at the time of the first screening visit. * asa classifications 1 and 2. * for women of childbearing potential, negative urine pregnancy test within 7 days of screening visit. willingness to use highly effective contraception during the entire study period (e.g.: implants, injectables, oral contraceptives, intra-uterine device or declared abstinence). * subject is fluent in english and understands the study protocol and informed consent and is willing and able to comply with study requirements and sign the informed consent form. non-english speakers will not be included in the study because consent forms are in english, and any instructions during exercise will need to be provided in english. exclusion criteria: subjects with any of the following conditions or characteristics must be excluded from the study: * history of any of the following: * prior gastric or esophageal surgery, including lap banding or bariatric surgery * bowel obstruction * gastric outlet obstruction * diverticulitis * inflammatory bowel disease * ileostomy or colostomy * gastric or esophageal cancer * achalasia * esophageal diverticulum * active dysphagia or odynophagia * active medication use for any gastrointestinal conditions * pregnancy or planned pregnancy within 30 days from screening visit, or breast-feeding * any form of active substance abuse or dependence (including drug or alcohol abuse), unstable medical or psychiatric disorder, or any chronic condition susceptible, in the opinion of the investigator, to interfere with the conduct of the study * a clinical condition that, in the judgment of the investigator, could potentially pose a health risk to the subject while involved in the study
safety and efficacy of ntx-001 compared to soc in acute single peripheral nerve injuries

Conditions: Peripheral Nerve Injuries

Summary: ntx-001 is a single use surgical product intended for use in conjunction with standard suture neurorrhaphy of severed nerves in patients between 16 and 80 years of age.

ntx-001 (product) is a surgical product that consists of an active solution (drug), an isolation chamber medical device (chamber or device) and two (2) other sterile solutions. ntx-001 has been developed as a surgical product to be used in conjunction with standard suture neurorrhaphy of a severed nerve. use of ntx-001 is intended to safely accelerate the often slow and diminished return of function in repaired nerves. it often takes months and/or years to determine if function will be restored. by that point, restoration is often incomplete and can result in lifelong motor and/or sensory deficits. by reconnecting (peg-fusion) a substantial number of axons within a severed nerve, the degeneration-regeneration cycle and subsequent atrophy may be reduced or even prevented for those axons and their targets, respectively. ntx-001 (peg-fusion) has the potential to avoid the consequences of protracted denervation of distal target tissues by eliminating the period of total denervation thus reducing the time to stable recovery and providing greater innervation to affected tissues.

Eligibility criteria:
inclusion criteria: * the subject is at least 12 years of age and not older than 80. * the subject has sustained a confirmed (intra-op assessment) single transected peripheral nerve injury. * the subject's nerve injury is classified as sunderland's fourth and fifth degree (class iii) * the subject's nerve injury is amenable to minimal or acceptable tension, in direct, end-to-end repair. * the surgical repair will occur within 48 hours of injury. exclusion criteria: * the subject has a pni with a segmental loss (gap) that cannot be repaired with minimal or acceptable tension. * other treatments known to affect the growth and/or physiology of the neural and vascular system. * the nerve injury has vascular damage that cannot be repaired to provide adequate perfusion of the injured site. * the subject is pregnant and/or is breastfeeding. * the subject has a significant medical comorbidity precluding immediate repair.
comparison of cardiorespiratory fitness among regular exercisers with and without parkinson disease and across different modes of group exercise

Conditions: Parkinson Disease

Summary: the central goal of the proposed study is to generate essential pilot data necessary to support an established line of research leading to future extramural grant submissions. the aims of the current study are two-fold: 1) to compare cardiorespiratory fitness (crf) and gait endurance across three groups of people: (1) individuals with parkinson disease (pd) who participate in boxing on a regular basis, (2) individuals with pd who participate in exercise other than boxing on a regular basis and (3) healthy controls of the same age who exercise on a regular basis and 2) to examine the relationship between crf and motor symptoms of pd (bradykinesia, tremor and postural instability). forty-five participants (15 for each group) who participate in exercise on a regular basis (at least 120 minutes of exercise per week for the past 3 months) will be recruited for this cross-sectional study. in a single testing session, participants will perform the following tests: (1) clinical performance measures and (2) a crf assessment. a one-way anova with appropriate post hoc tests will be used to examine differences in dependent variables across the three exercise groups. relationships between crf and clinical performance measures will be evaluated with pearson's correlation coefficients.


Eligibility criteria:
inclusion criteria: * all participants included in this study must be between the ages of 55 and 75 * be able to ambulate independently without physical assistance, assistive device, or lower extremity orthosis * be able to follow at least 3-step verbal commands * participate in a community-based group exercise program * be classified as regular exercisers by participating in 120 minutes per week for at least 3 months * and have a physician's consent to undergo a graded exercise test (gxt). * furthermore, only participants that are identified as low or moderate risk for cardiovascular disease based on acsm's risk stratification guidelines will be included in the study. * participants for the two pd groups must have a diagnosis of idiopathic pd * have a hoehn-yahr score of 1, 2, or 3 * and either participate regularly in boxing training at rock steady boxing or participate in another community-based group exercise program on a regular basis, classified as 120 minutes per week for at least 3 months. exclusion criteria: * participants may not be included in the study if they have had any surgery in the past 6 months * current musculoskeletal or complications from other health issues that influence walking. * the participants without disability cannot be involved in the study if they have any preexisting neurological conditions. * participants with pd cannot be involved in the study if they have preexisting neurological conditions other than idiopathic pd (e.g. no diagnosis of parkinson plus syndrome), past brain surgery or implantation of a deep brain stimulator.

Keywords: cardiorespiratory fitness group exercise
epidemiological study on mental health of migrant population in the retention center of geispolsheim.

Conditions: Mental Health of Migrant Population

Summary: in 2019, the lack of studies about mental health of the detained population at retention centers in france is pointed out by the report of controller-general for places of deprivation of liberty. the aim of this study is to contribute to this relatively untouched field by describing which psychiatric pathologies are encountered in this population who went through migration and retention. having a clearer picture of the situation can help to provide a more adapted psychiatric care in retention centers. the results are expected to show a higher rate of psychiatric disease than in the general population including addiction to substance, anxiety disorder and post-traumatic stress disorder (ptsd).


Eligibility criteria:
inclusion criteria: * any male person in the first week of detention at cra geispolsheim who gave their non-opposition to participation in the study. * information and consent protocol signed exclusion criteria: * refuse to participate to the study

Keywords: mental health psychiatric diseases migration retention center
internet-based intervention for skin self-examination in participants with increased risk for melanoma

Conditions: Dysplastic Nevus; Health Status Unknown; Melanoma; No Evidence of Disease

Summary: this trial studies an internet-based intervention for skin self-examination (sse) in participants at increased risk for melanoma. early detection of suspicious growths on the skin can be done by performing regular sse checks. using an internet-based intervention, such as mysmartcheck, may help to promote regular, thorough checks on the skin in individuals at increased risk for melanoma.

primary objectives: i. to evaluate the impact of mysmartcheck versus usual care on skin-self-examination (sse) behaviors among individuals at increased risk for developing melanoma. secondary objectives: i. to evaluate the impact of mysmartcheck versus usual care on patients barriers and benefits to conducting sse, sse self-efficacy (confidence), level of worry about developing melanoma, and number of health care consultations (visits, telephone calls, and emails). ii. to evaluate whether mysmartcheck effects are moderated by the patient's total body photography (tbp) status. iii. to identify barriers and facilitators to using mysmartcheck. outline: phase i: participants complete a telephone based usability testing of the online program. participants complete between 1-5 user testing sessions of the mysmartcheck program (about 45-60 minutes per session) to provide feedback on acceptability, satisfaction, comprehension, and usability. phase ii: participants are randomized to 1 of 2 groups. both the intervention and control group complete a baseline survey as well as a 13 weeks post-baseline survey. group i: after completing the baseline survey, participants receive access to the mysmartcheck program, and continue to receive standard of care. participants are asked to complete another survey 13 weeks post-baseline. group ii: after completing the baseline survey, participants receive standard of care. participants are asked to complete another survey 13 weeks post-baseline. study duration is 13 weeks for all participants.

Eligibility criteria:
inclusion criteria: * at increased risk for melanoma due to a personal history of treated melanoma without current evidence of disease, a family history of melanoma in a first-degree relative, and/or having a high-risk mole phenotype (i.e., \>= 50 normal moles or \>= 1 abnormal mole \[dysplastic nevus\]). * access to a computer connected to the internet. * not adherent to sse recommendations (i.e., did not conduct a thorough sse during each of the previous 3 months). * able to speak and read english. * able to provide informed consent.
comparative effectiveness and safety of elios in patients with open-angle glaucoma undergoing cataract surgery

Conditions: Open Angle Glaucoma

Summary: the primary study objective is to compare the effectiveness of the combination of phacoemulsification with intraocular lens implant with elios or competitor device in reducing iop at 12 months postoperatively.


Eligibility criteria:
inclusion criteria: 1. male or female subjects. 2. 40 years old or older. 3. diagnosis of mild to moderate primary open-angle glaucoma, pseudoexfoliation glaucoma or pigmentary glaucoma: 4. visually significant cataract eligible for phacoemulsification. exclusion criteria: 1. all forms of angle closure glaucoma 2. secondary glaucoma, including traumatic, neovascular, uveitic, lens-induced, steroid-induced, angle-recession, glaucoma associated with vascular disorders, and glaucoma associated with increased episcleral venous pressure 3. congenital or developmental glaucoma 4. prior incisional glaucoma surgery, intraocular surgery or ocular laser treatment of any type with the exception of selective laser trabeculoplasty (slt) occurring a minimum of 6 months prior to the screening visit

Keywords: excimer laser micro-bypass trabeculostomy
effects of resistance training on pain, function and work ability in patients with moderate to severe low back pain

Conditions: Low Back Pain

Summary: the purpose of this study is to investigate if high-intensity resistance training can induce additional beneficial effects, for patients with moderate to severe long term pain in the low back, when added to a multidisciplinary treatment program.


Eligibility criteria:
inclusion criteria: * referred to the multidisciplinary clinic for treatment of pain in low back * long term (≥ 3months) or recurrent (≥ 2 periods of ≥ 4 weeks the past year) non-specific low back pain * pain intensity ≥ 4 on numerical rating scale (0-10) exclusion criteria: * severe somatic condition (unstable injury, malignity, infectious disease, active rheumatic disease, severe osteoporosis) * psychiatric condition/disease that severely impairs group functioning * insufficient comprehension of norwegian language to participate in group sessions and fill out questionnaires * awaiting surgery of back * alcohol or drug abuse * ongoing compensation case or applying for disability benefits due to pain in the back * engaged in high-intensity resistance training on a regular basis the last 6 months

Keywords: exercise therapy resistance training multidisciplinary treatment
ultra-brief versus brief hands only cpr video training with and without psychomotor skill practice

Conditions: Cardiac Arrest

Summary: bystander cpr improves survival from out of hospital cardiac arrest. this study examines the efficacy of ultra-brief video training for hands-only cpr. subjects were randomized to one of four training conditions, then assessed for cpr skills retention.

bystander cpr improves survival from out of hospital cardiac arrest. this study is the first of its kind to examine the efficacy of ultra-brief video training for hands-only cpr without the use of a manikin. the results will inform future efforts to mass train citizens in cpr. subjects were randomized to one of four training conditions, then assessed for cpr skills retention. the four groups were 1) no training; 2) ultra-brief training video (90 seconds); 3) short training video (5 minutes) with no practice; and 4) short training video with hands-on practice. the subjects were then evaluated for cpr skills retention. one half of the subjects were evaluated on the training day, and the other half were evaluated two months later.

Eligibility criteria:
inclusion criteria: * members of a local area church exclusion criteria: * less than 18 years old * formal cpr training or certification within last 2 years * lacks fluency in english * works as a health care provider

Keywords: hands only cpr resuscitation cardiac arrest education of general public regarding resuscitation methods
gametes transfer vs. embryo transfer for women undergoing assisted reproductive techniques: a randomized controlled trial

Conditions: Infertility

Summary: background: the cost for the treatment of infertility are limiting for the health care access, particularly if we consider that the success rate per cycle is approximately 35%. alternative regimens for controlled ovarian stimulation (cos)have been described in the medical literature, that lead to a lower cost, fewer injections and less risk of adverse events, particularly ovarian hyperstimulation syndrome. furthermore, some services report excellent results with less manipulation as possible, which reduces the cost of laboratory of human and ethically be considered less complicated once fertilization occurs in the uterus and not in vitro. objectives: the main objective is to compare the reproductive outcomes between intrauterine transfer of gametes (tg) and embryos (te), the secondary objective is to estimate the average number of eggs that are raised when using an eoc reduced cost. methods: this study will be conducted in the area of human reproduction, department of gynecology and obstetrics hospital of the fmrp-usp. we will conduct an open controlled study with random allocation of the participants in a 1:1 ratio, and we plan to include 100 participants. all participants will undergo an eoc reduced cost. we will compare the chance of the treatment (te or tg) result in a live birth and clinical pregnancy per woman allocated and to estimate the number of oocytes retrieved considering all participants.


Eligibility criteria:
inclusion criteria: * women undergoing art requiring cos, oocyte retrieval and embryo transfer at the fertility clinic of the university hospital of the medical school of ribeirao preto, university of sao paulo, brazil. * age = 18-40 years * bmi = 18-30 kg/m² * antral follicle count (afc) ≥ 5 * semen concentration and progressive motility above the percentile 2.5 of the fertile men (cooper et al. 2010): sperm concentration \> 9x 10⁶/ml, and progressive motility \> 28%. exclusion criteria: * none

Keywords: assisted reproductive techniques health services accessibility ovulation induction embryo transfer