Kornimate/medical-research-clean huggingface dataset:
friends for life circles for option b plus

Conditions: Human Immunodeficiency Virus

Summary: the main goal of the study is to support hiv-infected pregnant women initiated on pmtct option b+ during antenatal to adhere to lifelong art and postpartum care visits through an enhanced group peer support intervention called "friends for life circles".

the overall goal of this implementation research is to improve retention in care and adherence to art to 2 years postpartum among hiv infected women in urban and rural uganda choosing pmtct option b+. formative research will first be conducted to assess knowledge and attitudes regarding option b+ and lifelong art among pmtct clients, community members and health workers. the formative research will inform the design of the group peer support intervention. interventional research will then be conducted randomizing 540 women to either enhanced group peer support with income generating activities called the friends for life circle (flc) or moh standard of care counselling with follow-up to 2 years postpartum. primary outcomes will include retention in health care, arv adherence and viral suppression at 6 weeks and 24 months postpartum. secondary outcomes will include participants' health and economic outcomes.

Eligibility criteria:
inclusion criteria * age \>18 years * documentation of pregnancy through clinical assessment or pregnancy test * documentation of confirmed hiv-positive sero-status at the time of screening * accepting to receive option b+ for pmtct * providing written informed consent to participate in the randomized trial. * agreeing to come the study clinic for scheduled appointments * agreeing to be home visited as needed to ensure follow up * residing within a 20 km radius around the study clinic * not planning to move out of the catchment area within the next 2 years exclusion criteria - social and other circumstances that may prevent the mother from coming back for follow up

Keywords: option b plus hiv infected women
evaluation of the dental movements caused by oral appliance in sleep apnea syndrome

Conditions: Sleep Apnea Syndromes

Summary: the do oam study is a mono-center, interventional, prospective study carried out in ch valence. it will estimate the prevalence of dental movements in patients treated by oral appliance for sleep apnea syndrome. the investigators will used fingerprinting technique by taking multiple photographs of the teeth that allow for the three-dimensional reconstruction of the teeth this study will provide a better understanding of dental movement caused by oral appliance

oral appliances are indicated for the treatment of sleep apnea syndrome. dentoskeletal effects of oral appliance are imperfectly assessed. the investigators want to study dental movements by comparing three-dimensional reconstruction of the teeth and the dental articulation in patients treated for sleep apnea syndrome in our hospital. the study consists of an additional acquisition of three-dimensional reconstruction of teeth. the data previously acquired during the first digital impression according usual practise will be compared to this additional acquisition.

Eligibility criteria:
inclusion criteria: * patient with a diagnosis of sleep apnea syndrome treated by oral appliances in ch valence * availability of previous digital impressions required for oral appliances manufacturing * age ≥ 18 years old * read, write and understand the french language exclusion criteria: * patient under guardianship, deprived of liberty, safeguard of justice * refusal to participate in research

Keywords: oral appliance dental movement
eardream data collection in colombia supported by addf

Conditions: Alzheimer Disease, Early Onset

Summary: data collection based on this study will allow us to collect neurophysiological and cognitive data collected from in-ear eeg recordings of the autosomal dominant alzheimer's disease population in colombia

there is solid neurophysiological evidence indicating that abnormal brain rhythms during sleep and noradrenergic dysfunction are core components of cognitive decline and ad onset, and their related pathophysiology. crucially, irregularities in these neurophysiological mechanisms appear to occur in an asymptomatic and pre-symptomatic stage, but their potential to identify susceptibility for triggering neurodegeneration has yet to be established. thus, the possibility to identify such risk biomarkers in humans will require the acquisition of large-scale data related direct or indirect measurements of these physiological signatures. a possible key source to obtain such large-scale data related to sleep and noradrenergic function is the assessment of electroencephalographic recordings through non-obtrusive, low-cost, and reliable wearable sensors, alongside the use of advanced neuro-computational algorithms that link brain function and behavioral outcomes of lc function via pupilometry measurements.

Eligibility criteria:
participants fulfilling all of the following inclusion criteria are eligible for the study: informed consent as documented by signature mutation and non-mutation carriers of adad populations patients diagnosed with mci and ad diseases or lesions of the nervous system (acute or residual included neurological and psychiatric diseases, except for mci and ad in the patient population) clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, etc.) sleep disorders, known or suspected (e.g. insomnia, sleep apnoea, restless leg syndrome, narcolepsy, etc.) mini mental state examination (mmse) score \> 24) participants are not eligible if they fulfill the following exclusion criteria: participation in another study with investigational drug/therapy/interventions within the 30 days preceding and during the present study (start date adapted accordingly) suspected drug- or medication abuse, or on-label sleep medication use during the time of the study infection/disease of the auditory canal or ear drum that could worsen with ear-dream application, or allergies to in-ear electrode materials (e.g., silver) pregnancy (not safety related, but relevant for data interpretation procedures given that pregnancy can result in sleep patterns that are different from the baseline measurements we intend to characterize) additional non-medical exclusion criteria may be defined for certain cognitive tasks (e.g. no glasses during experiments involving pupillometry).
the effect of instrument assisted soft tissue mobilization and stretching exercises in cerebral palsy

Conditions: Cerebral Palsy

Summary: the aim of the study; to investigate the effects of instrument assisted soft tissue mobilizations and stretching exercises on flexibility, spasticity, balance and functional mobility in patients with cp.

various intervention studies; reported positive results with edydm after carpal tunnel syndrome, myofascial trigger point, chronic low back pain, nonspecific thoracic spine pain, ankle instability, mastectomy and total joint arthroplasty. observational studies have shown positive results in improving posterior shoulder range of motion, hip, knee, and ankle rom. there is no study in the literature with edydm in patients with cp. many of the problems in which eddm is applied for fascia and muscle mobilization in different diseases are also seen in patients with cp. in current rehabilitation methods, stretching exercises are applied for muscle and fascia shortening. the advantages of the applications over each other are unknown. our study is planned as a study with high original value as it is the first study to be conducted using edydm in cases with cp. in our study, the effectiveness of edydm treatment, which will increase the effectiveness of stretching exercises in cp or can be an alternative treatment approach in cases with cp, will be compared with stretching exercises.

Eligibility criteria:
inclusion criteria: * having been diagnosed with unilateral spastic type cerebral palsy by the health committee report, * level i or ii according to gmfcs, * being between the ages of 5-18, * no botulinum toxin (botox) injection in the last 6 months, * not using any medication that may affect muscle tone, * passive ankle dorsiflexion + 10o and passive plantar flexion -25o, * families and children agree to participate voluntarily in the study. exclusion criteria: * having undergone any lower extremity surgery, * tone in plantar flexors is level iv according to mas, * presence of advanced contracture in the ankle, * presence of any diagnosed cardiac or orthopedic disorder that may prevent the application of the treatment, * hearing or vision problems, * having a history of epileptic attacks, * not having the ability to adapt to exercises (cases with the phrase "mental retarde" according to the health report).

Keywords: cerebral palsy instrument assisted soft tissue mobilization stretching exercises
colorectal cancer screening navigator program for low income and non-english speaking populations

Conditions: Colorectal Cancer

Summary: the goal of this study is to implement and in a controlled randomised trial test a program to identify and overcome barriers to crc screening and thus improve crc screening rates at mgh chelsea hc. our hypothesis is that a bilingual navigator program, enhanced by using trained interpreting staff will improve crc screening rates at mgh chelsea hc overall, and decrease disparities between patients with limited english proficiency and english speakers

we developed a training program for five health center interpreters fluent in eight different languages. patients randomly assigned to the study intervention receive an introductory letter in their native language. during the initial contact the navigator educates patients about crc screening and explores patients' barriers to crc screening. based on results from a qualitative study conducted at in 2006, we developed interventions to overcome individual barriers to crc screening tailored to each individual patient. specific interventions include elucidation of culturally-specific health beliefs; teaching about cancer risk, colonoscopy, and colon prep administration; and help with appointment-making and transport.

Eligibility criteria:
inclusion criteria: * between 52-79 years of age * have not had a colonoscopy within the last 10 years * have not had a sigmoidoscopy/barium enema within the past 5 years * have not had a home fecal occult blood testing within the past year. exclusion criteria: * acutely ill * dementia * metastatic cancer * schizophrenia * any end stage disease

Keywords: colorectal cancer cancer screening patient navigation low english proficiency
metabolic mechanisms of the electrophysiological biomarkers for response to methylphenidate treatment in children with adhd

Conditions: Methylphenidate; Metabolomics

Summary: to explore the relationship of treatment-related changes in electrophysiology and those in metabolomics for identification of the underlying metabolic mechanisms for the electrophysiological effects of methylphenidate in children with adhd.

although the efficacy of methylphenidate in reducing the core symptoms of attentiondeficit/ hyperactivity disorder (adhd) is well documented in clinical trials, no definite biomarker has been identified to differentiate responders from non-responders to methylphenidate treatment for children with adhd. in addition, the neural and metabolic mechanisms underlying the therapeutic effects of methylphenidate remain to be elucidated. in this 4-year prospective project, the investigators will explore the effects of 12-week treatment with methylphenidate on the electrophysiology and metabolomics of children with adhd to identify the biomarkers for predicting the clinical response to methylphenidate. in addition, the investigators will explore the metabolic mechanisms through which methylphenidate treatment may modulate the abnormality in the electrophysiology of children with adhd. specific aims: 1. to examine the differences in electrophysiology and metabolomics between children with adhd and neurotypical controls. 2. to examine the differences in the change of electrophysiology and metabolomics after 12-week treatment with methylphenidate between responders and non-responders in children with adhd. 3. to explore the relationship of treatment-related changes in electrophysiology and those in metabolomics for identification of the underlying metabolic mechanisms for the electrophysiological effects of methylphenidate in children with adhd.

Eligibility criteria:
1. patients with adhd 1. inclusion criteria * patients, aged 6 to 18 years, meet the dsm-5 diagnostic criteria for adhd. * at baseline, patients have a clinical global impressions-adhd-severity (cgi-adhd-s) score greater than 4. * patients have a full iq (fiq) score greater than 80. 2. exclusion criteria * patients have a major psychiatric disorder, such as autism spectrum disorder, schizophrenia, affective disorders, or substance use disorders. * patients have a major disorder of central nervous system, such as epilepsy. * patients have a major systemic disease, such as diabetes mellitus or cardiovascular diseases. * patients have ever received any medication to treat the clinical symptoms of adhd. 2. neurotypical participants: 1. inclusion criteria * aged 6 to 18 years * all of the neurotypical participants have no psychiatric disorder in lifetime according to the diagnostic criteria of dsm-5. 2. exclusion criteria * participants have any disorder of central nervous system or major systemic disease * participants have ever taken any psychotropic drug, or who have fiq scores less than 80, will be excluded from the present study.
effect of snags on stiffness of lumbar stabilizer muscles

Conditions: Low Back Pain; Manuel Therapy

Summary: low back pain is a common health problem worldwide. epidemiological studies have shown that 70-80% of all people are affected at least once in their lifetime. although it is common, often the cause of the pain has not been determined and is called 'nonspecific low back pain. low back pain has been shown to alter the structure of deep and superficial muscles such as multifidus and erector spinae. however, it has not been fully explained how changes in muscle fiber structure affect the biomechanical properties and functions of the muscle. there are various manual therapy techniques in the treatment of low back pain. manual therapists use treatment modalities that include passive techniques such as mobilization and manipulation. mobilization with movement (mwm) developed by mulligan involves applying a sustained transverse glide to the spinous process of a vertebra while actively or passively performing. these techniques have gained the name "sustained natural apophyseal glides" (snags) as it is maintained at the pain-free range and follows the plane of the apophyseal joints under treatment. ultrasound shear wave elastography (swe) provides an advantage since it can quantitatively assess tissue elasticity of in vivo skeletal muscles through non-invasive high-frequency ultrasound waves. the aim of this study was to investigate the acute effect of mulligan snags on the stiffness of muscle tissue by using ultrasound shear wave elastography which is an objective assessment technique.


Eligibility criteria:
inclusion criteria: * patients who diagnosed with non-specific low back pain * between the ages of 18-24 * patients who able to perform at least 40° of trunk flexion exclusion criteria: * patients who obese, pregnant, had specific low back pain * indication for surgery in the past 1 year * the trauma of lumbar region, and systemic inflammatory disease affecting this area * exercise and conventional physiotherapy in the last 6 months
the difference of microparticles in patients with psoriasis vulgaris who received stelara(ustekinumab)

Conditions: Psoriasis With Cell-derived Microparticles

Summary: background: psoriasis, a common inflammatory disease, is associated with atherosclerotic vascular diseases, including stroke, myocardial infarction, and impaired microcirculations, among which circulating microparticles play an important role. in severe psoriasis, there are increased endothelial- and platelet- microparticles that are reduced by tnf-α blockers in parallel with clinical improvement. however, whether stelara(ustekinumab) treatment would decrease the level of microparticles remains unknown. objective: the investigators will evaluate the level of microparticles among normal control, severe psoriasis before and 4 months after ustekinumab treatment.

methods: the investigators will recruit 50 patients with severe psoriasis who received ustekinumab and 50 control subjects without psoriasis from august 2014 to july 2016. concentrations of microparticles with expression for surface markers (annexin v, cd31, and cd41a) will be measured in peripheral blood using flow cytometry.

Eligibility criteria:
inclusion criteria: * patients with severe psoriasis who receive ustekinumab treatment. * patients in the control group are examined thoroughly to make sure no psoriatic lesions by two dermatologists. age, sex, lipid profiles, and blood pressure are recorded for all subjects. exclusion criteria: * the psoriatic patients and healthy controls who have pregnancy or infection (such as tuberculosis or sepsis) are excluded.
quantification of outcome measures for mind-body interventions

Conditions: Stress, Psychological; Stress, Physiological

Summary: the purpose of this study is to determine if participation in one of three different health management groups will elicit genomic and biochemical changes and decrease perceived stress levels and symptoms in healthy, stressed adults. the investigators expect that changes in self-reported psychological stress and symptoms will be directly linked to changes in biological indicators (genomic expression profiles and neuroendocrine and pro-inflammatory biomarkers).

this randomized, controlled trial will determine the relative strength of correlation between changes in stress outcome measures (self-report questionnaire, genomic expression, biochemical assay) in moderately to severely stressed healthy subjects randomized to one of three health education interventions at both end-intervention and at a 6-month long-term follow-up. this study will also determine which of the different outcome measures exhibit the greatest degree of sensitivity, reliability and consistency at both end-intervention and long-term follow-up.

Eligibility criteria:
inclusion criteria: * age 18 or older * stress is chronic and ongoing with no resolution of the stressors within the timeframe of the study, with a minimum prior duration of 6 months. * able to provide informed consent and to understand written and spoken english. exclusion criteria: * practice of yoga, meditation, guided imagery or other mind body techniques that elicit the rr, once per week for 45 min total or more within the last three months or less. * any current medical condition that would preclude their safe and effective practice of the yoga or meditation interventions. * the presence of bipolar or psychotic disorders, or history of any other dsmiv axis i disorder with active symptoms or treatment within the last 5 years, as determined by a structured clinical interview. * initiation of psychotherapy within 6 months of entering the study. * serious or unstable medical illness, including serious or unstable cardiovascular, hepatic, renal, respiratory, endocrine, neurologic or hematologic disease. * patient deemed unable to complete protocol due to cognitive, psychiatric or other reasons. * pregnancy or planned conception over the course of the study (could confound biomarker values). * current use of the following medications: systemic corticosteroids, chronic (i.e., more than 3 days per week) use of anti-inflammatories (e.g., ibuprofen; currently or within the last 3 months), immunosuppressive or cytotoxic therapies (currently or within the last 12 months), and anabolic steroids. * current (within the last 6 months) psychoactive medications (e.g. antidepressants, mood stabilizers, antipsychotics, anxiolytics), with the exception of hypnotics, which will be permitted.
passive limb movement study

Conditions: Stroke; Vascular Diseases; Ischemic

Summary: stroke survivors have compromised vascular function which may contribute to secondary stroke risk, cardiovascular disease, and may limit their exercise tolerance. no studies have examined how femoral blood flow responds to both passive leg movement, a measure of microvascular function, as well as active leg contractions, a measure of the hyperemic response to exercise. leg muscles with a reduced blood flow response to movement could be associated with decreased neuromuscular function, such as leg strength and fatigue. preliminary data showing a single bout of ischemic conditioning may improve vascular function and muscle activation in healthy adults and individuals post-stroke. therefore, the investigators want to examine if ischemic conditioning will also improve the blood flow response to passive leg movements as well as during single leg active contractions.


Eligibility criteria:
inclusion criteria: * individuals post-stroke * 18 - 85 years of age * cortical or sub-cortical stroke ≥ 6 months ago with residual hemiparesis * able to give informed consent and follow 2-step command. * english speaking * age- and sex-matched controls (con) * matched to age of individual post- stroke ± 5 years. * matched to sex of individual post-stroke * able to give informed consent and follow 2-step command. * english speaking * young healthy adults (conyoung) * age 18-30 years old * able to give informed consent and follow 2-step command. * english speaking exclusion criteria: * all groups * unable to stand from chair and walk 10 meters without physical assistance from another person (able to use assistive device). * history of blood clots in the extremities or any condition in which compression of the thigh or transient ischemia is contraindicated (i.e., wounds in the leg). * chronic lasting symptoms (\> 6 months) of severe covid-19 (i.e., hospitalization) * low back or hip pain that limits lower extremity motor testing. * history of head trauma or concussion within the past 6 months * comorbid neurological disorder * peripheral vascular disease * myocardial infarction in the previous year * condition where fatiguing contractions or resisted leg contractions are contraindicated * resting sbp ≥180 mmhg or dbp ≥ 100 mmhg * pregnancy or breastfeeding. * other significant medical condition likely to influence study or jeopardize safety as assessed by the primary investigator * con and conyoung * history of stroke

Keywords: ischemic conditioning blood flow peripheral microvascular function neuromuscular function