Kornimate/medical-research-clean huggingface dataset:
mild preeclampsia near term: deliver or deliberate?

Conditions: Preeclampsia

Summary: preeclampsia with new-onset hypertension and proteinuria is a pregnancy-specific disease that affects 5-7% of gestations usually after the 20th week. most cases are mild, but severe cases exhibit multiple abnormalities in blood and maternal organ systems. severe forms of preeclampsia/eclampsia are a major contributor to maternal death in the world. delivery stops disease progression and recovery can begin. patients with mild preeclampsia between 34-38 weeks' gestation usually are hospitalized for evaluation and close monitoring of signs, symptoms, and certain laboratory studies as reflectors of disease status. as inpatients mothers are monitored frequently for evidence of maternal or fetal compromise until 38 weeks gestation when delivery is accomplished. if a patient with mild preeclampsia labors after 34 weeks, no attempt is made to stop labor and delivery is undertaken. it remains unclear when during the third trimester that delivery should be accomplished for maximal maternal safety and minimal fetal risk. in this research project, we will identify patients who are at least 34 weeks pregnant with mild preeclampsia. after informed consent to participate in the trial, we will randomize participants to either be delivered immediately or treated with observation and maternal-fetal surveillance in hospital as described previously with delivery at 38 weeks. there will be 110 participants enrolled in each arm of the study for a total of 220 patients who will be managed in the wiser hospital. we intend to analyze a number of maternal and fetal outcomes including cost comparisons for the care of both mother and fetus in the two groups of randomized patients. the findings should impact care of the pregnant patient with mild preeclampsia in the third trimester with regard to how early and how late in gestation that delivery should be accomplished for optimal maternal and perinatal benefit.


Eligibility criteria:
inclusion criteria: * mild preeclampsia equal to or greater than 34 weeks' and less that 38 weeks' gestation singleton gestation no maternal or fetal contraindications to conservative management exclusion criteria: * non-gestational diabetes chronic hypertension severe preeclampsia non-reassuring fetal assessment intrauterine growth restriction fetal anomalies multiple gestation premature preterm rupture of membranes placenta previa unexplained vaginal bleeding antihypertensive use current gestation poor dating criteria contraindication to conservative management active labor at admission

Keywords: mild preeclampsia
inspiratory muscle training in copd

Conditions: COPD

Summary: this proposal aims at evaluating an inspiratory muscle training (imt) method not previously tested in copd called the test of incremental respiratory endurance (tire). as a training method, tire promises to provide further benefits over standard imt because it allows the user to adjust training loads as progress is made, adjusts the training based on day-to-day variations commonly noted in copd, and provides a graphic representation of the inspiratory effort throughout all inspiration with real-time biofeedback in order to "coach" the user in performing the exercises. the tire device can also be used as an assessment tool, not only to measure the commonly used measure of inspiratory muscle strength maximal inspiratory pressure (mip), but also measuring the mip variation generated throughout a maximal sustained inspiration. in this way, tire integrates mip over the inspiratory duration (id), providing a novel derivative measure called the sustained maximal inspiratory pressure or smip, that is likely a better surrogate of inspiratory muscle performance in copd based upon preliminary data. the main goal of this trial is to fully evaluate the utility of tire as an imt method in veterans with copd. the investigators hypothesize that as a stand-alone therapy, tire training is superior to standard imt in improving inspiratory muscle strength and endurance and in improving copd-related clinical outcomes.


Eligibility criteria:
inclusion criteria: * male or female aged \> 40 years with a confirmed diagnosis of copd by a pulmonologist (presence of risk factors and airflow obstruction) and evidence of inspiratory muscle weakness as defined by the latest american thoracic society / european respiratory society statement on respiratory muscle training. exclusion criteria: * refusal to participate in the study, subjects actively undergoing pulmonary rehabilitation, inability to perform the required maneuvers (i.e. patients with cerebrovascular accident or tracheostomy), subjects not in their stable state (i.e. having an acute exacerbation or within 4 weeks of having one) or presence of important comorbidities that may confound the interpretation of tire measures (i.e. decompensated heart failure, diaphragmatic paralysis, prior lung surgery, active cancer treatment, etc.). there will be no involvement of vulnerable populations.

Keywords: maximal respiratory pressures, inspiratory muscle training, tire, copd
treatment comparison for undergraduate college students with traumatic brain injury

Conditions: Traumatic Brain Injury; Concussion, Brain

Summary: up to 28% of undergraduate college students report a suspected history of traumatic brain injury. following traumatic brain injury, college students fail and repeat more courses and have lower grade point averages. further complicating this problem may be the fact that college students lack knowledge of traumatic brain injury definition, its associated symptoms, and individuals involved in post-injury management. in this project, the investigators propose to compare the use of an established treatment model (i.e., the dynamic coaching model) to a novel protocol (i.e., the apprenticeship approach) that includes explicit instruction about traumatic brain injury in college students with this population. the investigators will use a group comparison design to examine the efficacy of this instructional component. this work incorporates findings from educational psychology and speech-language pathology (e.g., the included instructional materials adhere to the principles of adult learning). as such, this work will advance the field's basic understanding of currently recommended treatment components and will systematically examine the effects of incorporating explicit instruction into an existing treatment model.


Eligibility criteria:
inclusion criteria: * a documented history of mild, moderate, or severe traumatic brain injury no more than 36 months prior to study initiation * speak english as a primary language * at least 18 years of age * demonstrate no barriers related to hearing, vision, reading, or technology that prevent successful experimental task completion. exclusion criteria: * no documented history of mild, moderate, or severe traumatic brain injury * injury occurred more than 36 months prior to study initiation * do not speak english as a primary language * are not at least 18 years of age * demonstrate barriers related to hearing, vision, reading, or technology that prevent successful experimental task completion.
hypotension after anesthetic induction with remimazolam in elderly

Conditions: Hypotension

Summary: even though remimazolam is known to be safely administered without hemodynamic instability, hypotension is the one of the common side effects of remimazolam. because elderly patients are susceptible to hypotension due to old age, multimodality, and multiple medications, hypotension can be harmful in elderly patients. remimazolam can be administered either bolus or continuous for anesthetic induction. in our study the investigators aimed to compare the incidence of hypotension after anesthetic induction using remimazolam by bolus injection and continuous infusion in elderly patients.


Eligibility criteria:
inclusion criteria: * elderly patients with age over 60 years old * scheduled for elective surgery under general anesthesia * american society of anesthesiology physical status i-iii exclusion criteria: * arrhythmia * liver dysfunction * kidney dysfunction * uncontrolled hypertension * uncontrolled diabetes mellitus * allergic to benzodiazepines * heart failure * drug intoxication * alcoholics * cognitive dysfunction * unable to understand and consent voluntarily
erlotinib and sequential positron emission tomography (pet) in advanced non small cell lung cancer (nsclc)

Conditions: Carcinoma, Non-Small-Cell Lung

Summary: this is a phase-ii study to evaluate the accuracy of fluorodeoxyglucose-/fluorothymidine-positron emission tomography (fdg-/flt-pet) analyses for early prediction of non-progression in patients with non-small-cell lung cancer (nsclc) treated with erlotinib.


Eligibility criteria:
inclusion criteria: * written informed consent * ≥ 18 years of age * untreated non-small-cell lung cancer stage iiib/iv * life expectancy \> 3 months * performance status ecog 0-2 exclusion criteria: * concurrent systemic immune therapy, chemotherapy or therapy with any anticancer drug not indicated in the study protocol * any investigational agent(s) within 4 weeks prior to study entry * previous administration of any egfr-targeted therapy (antibodies, small molecules and others) * any medical, mental or psychological condition which in the opinion of the investigator would not permit the patient to complete the study or understand the patient information

Keywords: advanced non-small-cell lung cancer erlotinib fdg-pet flt-pet
brain biomarkers of response to treatment for apraxia of speech

Conditions: Aphasia; Stroke

Summary: the study will use mri brain imaging to identify brain changes associated in stroke patients after they receive speech-language treatment for their speech difficulties.

the goals of the current study are to identify grey and white matter regions that are predictive of speech treatment response and measure neural plasticity in response to speech treatment, using state-of-the-art neuroimaging and statistical processing techniques in a group of well-characterized left hemisphere patients meeting strict inclusionary criteria. specifically, the investigators will use voxel-based lesion symptom mapping to identify lesion sites most predictive of a positive response to speech treatment and advanced diffusion imaging techniques to map changes in the integrity of white matter tracts from pre- to post-treatment.

Eligibility criteria:
inclusion criteria: * inclusion criteria are age 40-90 * primary english speaker since \< age 5 * a history of a single left hemisphere stroke * at least 1 year post-stroke * at least 12 years of education * pre-morbidly right-handed (edinburgh handedness questionnaire) * within normal limits on the test of non-verbal intelligence exclusion criteria: * exclusion criteria will include a pre-morbid neurologic or psychiatric history * history/current substance abuse disorder * mri contraindications * other motor speech disorders (e.g., dysarthria) * current or recent (\<2 months) speech/language therapy * prior spt * pre-morbid history of speech/language disorders * significant hearing disabilities (based on a pure-tone audiological screen at 35 db hl at 500, 1k, and 2k hz for at least one ear) * aphasia severity resulting in \<30th percentile performance on the porch index of communicative ability-r

Keywords: aphasia stroke magnetic resonance imaging diffusion magnetic resonance imaging
xbox kinect training in men with prostate cancer

Conditions: Prostate Cancer

Summary: the purpose of this study is to investigate the effect of 12 weeks systematically training using the xbox kinect system. outcome measures are made on physical function, quality of life, fatigue and metabolic parameters.

patients will be recruited from the outpatient clinic at the urological department, regionshospitalet holstebro. patients who have been discharged from the outpatient clinic due to biochemical stabile cancer prostate disease will receive a letter with information about the study. a research assistant will be responsible for randomization and test procedures. a physiotherapist will be responsible for instruction of the participants to the training and the xbox system. a student will be responsible for installation and collection of the xbox system in the participants home.

Eligibility criteria:
inclusion criteria: * prostate cancer requiring androgen deprivation therapy * androgen deprivation therapy for at least 3 month prior to inclusion * cognitive well-functioning in order to be able to answer questionnaires and train according to instructions * signed informed consent exclusion criteria: * prostate cancer with metastasis to other regions than bones * strength- or cardiovascular training 2 times or more per week prior to inclusion * haemoglobin percentage less than 6,1 mmol/l * any mental or physical condition that makes the patient unfit for participation * men in risk of getting an osteoporotic fracture due to long-term treatment with steroids or earlier fractures due to minimal trauma * participation in other studies

Keywords: prostate cancer androgen deprivation therapy exercise xbox
efficacy and safety of broncho muco cleaner balloon dilation therapy

Conditions: COPD

Summary: in copd patients with chronic bronchitis, it is aimed to determine whether the broncho muco cleaner balloon dilation method can provide clinical and functional benefit by causing destruction in hyperplasic goblet cells in the bronchial system. although 2 studies have been published on this subject before, one of them is a retrospective design and the other is a pilot study consisting of only 10 patients . therefore, it is clear that it should be supported by a controlled prospective study with more patients. within the scope of the research, broncho muco cleaner balloon dilatation treatment will be performed with fiberoptic bronchoscope under general anesthesia in chronic bronchitis-predominant copd cases, and the effectiveness and reliability of the procedure will be evaluated.


Eligibility criteria:
inclusion criteria: * adults of both sexes aged 40-75 years * being diagnosed with stage ii-iv chronic bronchitis-predominant copd according to the gold guideline * to have quit smoking for at least 6 months * mmrc 2 and above * receiving optimal medical treatment for copd * being stable for at least 3 weeks * to have completed 6 weeks of pulmonary rehabilitation before the first procedure * having sufficient mental and physical capacity to sign the voluntary consent form for the procedure. exclusion criteria: * be under the age of 40 and over the age of 75 * pregnant patients * breastfeeding a child * being an active smoker * concurrent asthma * chronic kidney disease with gfr \<30 ml/min * clinically significant arrhythmia, left heart failure (ef\ 45 mmhg) * liver cirrhosis * those who use anticoagulants or clopidogrel or equivalent drugs and cannot be stopped before and during the procedure, or the presence of bleeding diathesis * 6 minutes walking test \<100 meters * fev1\<15% * those with positive early reversibility in pulmonary function tests * patients who do not regularly take 15lgu15in therapy for copd * emphysema-predominant copd patients * presence of active malignancy * partial co2 pressure \> 55mmhg or po2\<55 mmhg in room air * active pulmonary infection * pneumothorax or pulmonary surgery in the last 6 months * patients with other clinically significant lung disease other than copd * those who have undergone a previous lung device procedure, including implanted emphysema stents, lung coil delivery, valves, lung denervation, or other devices for emphysema. * those taking \> 10 mg of prednisolone per day * those with a known sensitivity to the drug (such as lidocaine, 15lgu15ine and benzodiazepines) needed to perform bronchoscopy.

Keywords: chronic bronchitis medical device baloon dilatation
combating maternal mortality in uganda: an assessment of the role of misoprostol in prevention of post-partum hemorrhage

Conditions: Post Partum Hemorrhage

Summary: null hypothesis: 10 iu oxytocin is better than sublingual misoprostol 600µg in management of third stage of labor alternative hypothesis: sublingual misoprostol 600µg is non- inferior to 10 iu oxytocin and will not be more than 6% worse \[than 10 iu oxytocin\] in management of third stage of labor

background: in sub- saharan africa, one in 35 women die in child birth, 1000 times higher than the western world and post-partum hemorrhage (pph) accounts for the biggest percentage of maternal morbidity and mortality (who, 2005; who, 2010). maternal mortality in uganda is one of the highest in the world at 435 for every 100,000 and 25% of these are due to pph happening within 24 hours after delivery. oxytocin, the standard of care in pph management has registered challenges like requirement of sterile injections, requirement of trained personnel, special supply chain/storage conditions like refrigeration and protection from light affecting maximum treatment outcomes especially in poorly resourced developing countries where these are not realized. it has been argued that any effort or developments based on physiological processes towards the reduction of this horrific pph rate would greatly have a significant impact on the lives of families and women worldwide. several scholars have thus stressed a vital need to develop simple, practical and inexpensive techniques relevant to prevent and treat pph in developing countries.

Eligibility criteria:
inclusion criteria:term mothers \[38-41 woa\] above 18 years of age admitted at mbarara hospital, uganda in active labor; anticipating vaginal delivery - exclusion criteria: complicated labor: 1. confirmed intra-uterine fetal death 2. self-reported maternal heart disease 3. current diagnosis of severe malaria or acute bacterial infection, 4. multiple pregnancy, 5. induced or augmented labor, 6. elective caesarean section, 7. ante-partum hemorrhage, 8. reported hypersensitivity to prostaglandins 9. altered cognitive status (acs) as assessed by the mras. -
left ventricular function and remodelling during permanent pacing

Conditions: Sick Sinus Syndrome; AV-Block

Summary: 1. background - pacemaker treatment gives asynchronous activation of the heart that often results in decreased heart function and clinical heart failure. new pacemaker types that stimulates both left and right ventricle ( biventricular pacemakers ) is introduced to the treatment of patients with heart failure, decreased left ventricular function and ecg signs with left bundle branch block. 2. hypothesis - ventricular pacing results in remodelling of the left ventricle and decreased left ventricular function. biventricular pacing do not do this. ventricular pacing results in heart failure and increased wall stress with decreased 6 minutes walk test and increased bnp in blood samples. this is not seen by biventricular pacing. 3. materials and methods - 3 studies. all patients are examined by echocardiography 2-dimensional, m-mode, 3-dimensional and with tissue harmonic imaging. study 1) patients with av-conduction disorder that needs pacemaker treatment are randomized to ddd-pacemaker or biventricular pacemaker. study 2) patients with sick sinus syndrome included in danpace are randomized to aai- or ddd-pacemaker. study 3 ) acute study to examine the changes in patients av-block before ddd-pacemaker implantation and after implantation.


Eligibility criteria:
inclusion criteria: * sick sinus syndrome * av-block exclusion criteria: * atrial fibrillation * ami * heart valve disease

Keywords: sick sinus syndrome av-block
sleep apnoea syndrome without chronic heart failure

Conditions: Sleep Apnoea Syndrome

Summary: it is the objective of this study to collect scientific data of sleep apnoea syndrome patients´ cardiac and respiratory function by additional sensors.


Eligibility criteria:
inclusion criteria: * patients with supected sleep apnoea syndrome and scheduled diagnosis at a sleep laboratory * male and female patients aged at least 18 years * persons who understand and follow the instructions of the study staff * singed informed consent exclusion criteria: * persons being housed in an institution by court or governmental order * pregnancy or breastfeeding * patients who are not able to consent * acute or chronic inflammations of the external and middle auditory canal * abnormal anatomic proportionsof the external and middle auditory canal which are pathological or congenital, for example limitation of the auditory canal * persons in a dependence or in an employment contract to the investigator * participation in another study at the same time
screening in myocardial perfusion patients

Conditions: Breast Cancer

Summary: to expand the understanding of the uptake and distribution of tc-99m sestamibi in the breast in a normal female population undergoing myocardial perfusion imaging using molecular breast imaging (mbi).

you are being asked to take part in this research study because you have been scheduled to have a scan of your heart. the radioactive dye used to image your heart is also taken up by many types of breast cancer. the investigators have developed a new method for detecting breast cancer, called molecular breast imaging that uses this dye. the purpose of this study is to see how well this new method works in normal subjects with no known breast cancer and to see if we can detect breast cancer at an earlier stage than mammography. as you read this form describing the study, ask any questions you have. take your time to decide. feel free to discuss the study with your family, friends, and healthcare provider before you decide. you may stop participating at any time during the study. you may decide not to participate. if so, none of your current benefits or normal health care will be affected in any way. when you feel comfortable that all your questions have been answered, and you wish to take part in this study, sign this form in order to begin your participation. your signature means you have been told about the study and what the risks are. your signature on this form also means that you want to take part in this study.

Eligibility criteria:
inclusion criteria: * they have had a mammogram at mayo clinic rochester within the last 12 months * undergoing myocardial perfusion imaging exclusion criteria: * they are unable to understand and sign the consent form * they are physically unable to sit upright and still for 20 minutes * they have undergone breast surgery or breast biopsy within the last 12 months. * they have had trauma to the breast tissue or undergone radiation treatment to the breast within the last 12 months.

Keywords: breast breast cancer mbi molecular breast imaging molecular imaging