Kornimate/medical-research-clean huggingface dataset:
to linguistically and psychometrically validate the hong kong chinese version of the bph 3-item questionnaire

Conditions: Benign Prostatic Hyperplasia (BPH)

Summary: this study is to linguistically and psychometrically validate the translated and culturally adapted hong kong chinese version of the bph 3-item questionnaire.

a new bph 3-item questionnaire has recently been developed and published, and it may serve as a screening tool for male-luts due to symptomatic bpe. the questionnaire consists of only three items. a raw score ranging from 0 to 5 is assigned to each of the items, giving a final total score varying from 0 (no symptom) to 15 (very symptomatic). this questionnaire has been translated and validated into five different european languages and was harmonized cross-culturally for linguistic validation, followed by psychometric accuracy testing. this new questionnaire may help rationalize more early commencement of therapy aimed at reducing the prostate size for the treatment of male luts due to bpe.

Eligibility criteria:
inclusion criteria: * 18 - 90 years old chinese male subjects presented with male-luts for at least 4 weeks * the subjects are able to read and fully comprehend with the content of the questionnaires * the subjects are willing to give informed consent for the study exclusion criteria: * peak uroflow ≤4ml/sec; * post-void residual (pvr) ≥300 ml; * unable to give informed consent * need of clean intermittent self-catheterization / indwelling urethral catheterization at the time of enrolment; * surgical treatment (e.g. turp) of bladder outlet obstruction / symptomatic benign prostate enlargement (bpe) ≤ 3 months before entry into the study * clinical suspicion / presence of untreated urethral stricture and/or bladder neck stenosis, * clinical suspicion / presence of genitourinary cancer including active prostate cancer with ongoing surgical or radiation treatment, or the need of treatment, or bladder cancer, or persistent unexplained hematuria; * uncontrolled heart failure / diabetes mellitus(dm) / hypertension(ht); * neuropathic bladder; * currently on dialysis or in consideration for dialysis due to end stage renal disease; * more than 3 urinary tract infections within the last 12 months; * unstable dose of diuretic within the past 3 months; * has an artificial urinary sphincter; * impaired mental status; * male-luts due to urinary tract infections / chronic prostatitis / chronic pelvic pain
efficacy of repetitive transcranial magnetic stimulation and cognitive behavioral therapy on alcohol dependence

Conditions: Alcohol Dependence

Summary: alcohol dependence is one of most common substance dependence, which brings great burden on health worldwide. alcohol dependence may lead to many serious diseases or consequences including cancer, cardiovascular diseases and accidents. once alcohol dependence is developed, it will be difficult to recover and easy to relapse. although many efforts had been made in the treatment of alcohol dependence, the annual recurrence of alcohol dependence with traditional therapies was over 45%. repetitive transcranial magnetic stimulation (rtms) on the dorsolateral prefrontal cortex (dlpfc) or cognitive behavioral therapy (cbt) each alone was reported to have some effect on preventing from relapse of alcohol dependence. in order to test whether combined therapy of high frequency rtms (hf-rtms) with cbt is better for preventing from relapse of alcohol dependence, we recruit patients with alcohol dependence to participate this study. the study is a factorial designed and the patients will be assigned into one of the following six groups randomly: (1) regular treatment (symptomatic treatment) with blank tms; (2) regular treatment (rt) with blank tms and cbt; (3) rt with right dlpfc hf-rtms; (4) rt with right dlpfc hf-rtms and cbt; (5) rt with left dlpfc hf-rtms; (6) rt with left dlpfc hf-rtms and cbt. tms was given 5 days per week for total 2 weeks using uniform scheme (5 seconds of 10hz stimulation per train, 30 trains per day with inter-train interval of 20 seconds). cbt will be given once per week for total 8 weeks. the patients will be followed up for 6 months. recurrence of alcohol dependence, duration of abstention, alcohol intake, craving for alcohol and other cognitive psychological assessments will be recorded and compared among the 6 treatment groups and the efficacy of combined therapy of rtms with cbt will be evaluated in our study.


Eligibility criteria:
inclusion criteria: * diagnosis as alcohol dependence according to dsm-iv criteria * no definite history of neurological diseases and psychological problems * volunteer to participate the study, cooperate to be followed up exclusion criteria: * acute withdrawal state and ciwa score \> 9 * with other neurological diseases and psychological problems * with ever brain trauma and damage * with other psychological medications or other substance dependence * with other contraindications to have transcranial magnetic stimulation

Keywords: alcohol dependence, transcranial magnetic stimulation, cognitive behavioral therapy
heart to health: a combined lifestyle and medication intervention to reduce cardiovascular disease (cvd) risk

Conditions: Cardiovascular Disease; Coronary Heart Disease

Summary: cardiovascular disease (cvd), including heart disease and stroke, is the leading cause of death in the us. every year, more than one million americans have a heart attack, and nearly 800,000 have a stroke. in 2010, heart disease alone is expected to cost the country more than $316 billion in health care and lost productivity. both lifestyle changes and medication can reduce the risk of cvd, and this project combines these approaches in the hopes of identifying a practical intervention for use in primary care medical offices. the project combines two previously tested interventions and updates them to meet current guidelines for diet and use of aspirin and cholesterol-controlling drugs (statins). the research team is delivering the combined intervention in two formats: web-based and counselor-based. each format has the same content, but the web-based advice is accessed through the internet by clients at home, a community site, or a primary care office. the other format involves sessions delivered to clients by a counselor either in person at a primary care office or over the telephone. the researchers will compare how effective each format is in reducing participants' risk of coronary heart disease. they will also determine the interventions' effect on participants' diet, physical activity, smoking status, medication adherence, and other health indicators. in addition, the team will compare the two formats' cost-effectiveness and how well the patients, office staff, and clinicians accept the interventions. recruited from five family practices, 600 patients representing the geographic and ethnic diversity of north carolina are taking part in this study. half the participants are randomly assigned to the web-based intervention; the other half to the counselor-based version. both groups will also get information on local resources, such as gyms and farmers markets, that can help participants maintain a healthy lifestyle.


Eligibility criteria:
inclusion criteria: * established patients * men ages 35-79 * women ages 45-79 * history of cvd (100 participants) * chd risk equal or greater than 10% * elevated chd risk factor exclusion criteria: * non-english speaking * no phone * treatment of psychosis * history of alcohol/substance abuse within last 2 years * pregnancy, breast feeding, or anticipated pregnancy in next 18 months * history of malignancy, other than non-melanoma skin cancer, that has not been in remission or cured surgically for \>5 years * recent history (in past year) of hypoglycemic event requiring medical attention * estimated creatinine clearance less than 30 ml/min

Keywords: diet interventions physical activity interventions medication adherence tailored interventions
comparing angiomax to heparin with protamine in patients undergoing cardiopulmonary bypass (cpb)

Conditions: Cardiovascular Disease; Coronary Artery Bypass Surgery

Summary: the purpose of this study is to demonstrate that in patients undergoing coronary artery bypass grafting (cabg) or cabg-valve, or isolated cardiac valve surgery on cpb (cardiac surgery), angiomax is a safe and effective alternative anticoagulant to heparin with protamine reversal.


Eligibility criteria:
inclusion criteria * provide written informed consent before initiation of any study related procedures. * be at least 18 years of age. * be scheduled for cabg, cabg and single valve surgery, or isolated single valve surgery on cpb. patients undergoing repeat (redo) cabg are also considered eligible for this study. exclusion criteria * confirmed pregnancy at time of randomization via ivrs (if woman of child-bearing potential) (urine or serum pregnancy test) * cerebrovascular accident within 6 months, or any cerebrovascular accident with a residual neurological deficit. * intracranial neoplasm, arteriovenous malformation or aneurysm. * dependency on renal dialysis or creatinine clearance \<30 ml/min. * ongoing treatment with warfarin (or other oral anticoagulant) at the time of randomization. patients previously treated with warfarin may be enrolled if warfarin therapy can be safely discontinued and baseline inr is \< 1.3 times control in the absence of heparin therapy. * known allergy to angiomax or hirudin-derived drugs, or known sensitivity to any component of the product. * patients receiving clopidogrel (plavix®) within the previous 5 days of randomization * patients receiving a glycoprotein iib/iiia inhibitor within the previous 48 hours if abciximab (reopro®) or 24 hours if eptifibatide (integrilin®) or tirofiban (aggrastat®) of randomization. * patients receiving lepirudin (refludan®) or argatroban within the previous 24 hours prior to randomization. * patients receiving lmwh or thrombolytics within the previous 12 hours or unfractionated heparin within 30 minutes of randomization. * participation in other clinical research studies involving the evaluation of other investigational drugs or devices within 30 days of randomization. * refusal to undergo blood transfusion should it become necessary. * any other disease or condition, which, in the judgment of the investigator, would place a patient at undue risk by being enrolled in the trial, or cause inability to comply with the trial. * planned surgical procedure in which proximal anastomoses will precede distal anastomoses of the bypass grafts. * planned (\>1) double (or greater) valve repair-replacement (e.g.: avr-mvr) surgery.
comfort level of two abdominal compression methods used to hold patients still while undergoing stereotactic body radiation therapy for lung tumors

Conditions: Lung Cancer

Summary: rationale: stereotactic body radiation therapy may be able to send x-rays directly to the tumor and cause less damage to normal tissue. abdominal compression methods that hold the body and the tumor from moving during treatment may permit radiation therapy to kill more tumor cells. this study is looking at the comfort level of two abdominal compression methods in patients with lung tumors undergoing stereotactic body radiation therapy. purpose: this phase i trial is studying the comfort level of two abdominal compression methods used to hold patients still while undergoing stereotactic body radiation therapy for lung tumors.

objectives: primary * to evaluate comfort associated with the existing screw-based abdominal compression device and the new automated abdominal compression device in patients with lung tumors undergoing stereotactic body radiotherapy. secondary * to evaluate tumor motion in patients using these devices. outline: this is a multicenter study. patients undergo fluoroscopic assessment of tumor motion with a screw-based abdominal compression device. patients then undergo non-contrast 4d-ct imaging with the screw-based abdominal compression device followed by contrast 4d-ct imaging with an automated abdominal compression device. immediately after stereotactic body radiotherapy simulation, patients complete a questionnaire to assess the overall level of comfort of each abdominal-compression device.

Eligibility criteria:
disease characteristics: * all lung patients from the university of texas southwestern medical center, parkland health and hospital system, and richardson regional cancer center scheduled to receive stereotactic body radiotherapy simulation * must have initial pre-compression lung tumor motions with respiration \> 1 cm patient characteristics: * negative pregnancy test prior concurrent therapy: * concurrent participation in other protocols allowed

Keywords: stage i non-small cell lung cancer stage ii non-small cell lung cancer stage iiia non-small cell lung cancer stage iiib non-small cell lung cancer stage iv non-small cell lung cancer recurrent non-small cell lung cancer pulmonary carcinoid tumor extensive stage small cell lung cancer limited stage small cell lung cancer recurrent small cell lung cancer
a study on the effectiveness of laparoscopic fundoplication on extraesophageal manifestations of gastroesophageal reflux disease (gerd)

Conditions: Extraesophageal Symptoms; Gastroesophageal Reflux Disease (GERD)

Summary: available data regarding the effectiveness of laparoscopic antireflux surgery on extraesophageal symptoms of gastroesophageal reflux disease (gerd) are scarce and mostly controversial. the aim of the present study was to evaluate the clinical effect of partial and total fundoplication on extraesophageal symptoms in a selected cohort of patients with gerd.


Eligibility criteria:
inclusion criteria: * persistent or recurrent symptoms despite continuous medical treatment, at least one typical reflux symptom (heartburn/ regurgitation/dysphagia/epigastric pain) and/or at least one atypical reflux symptom (cough/ asthma/hoarseness/distortion of taste), pathologic esophageal acid exposure as documented by a reflux-related demeester score ≥14.7, and symptom correlation ≥50%, and/or reflux episodes \>73. exclusion criteria: * previous esophageal or gastric surgery, poor physical status (american society of anesthesiologists (asa) scores iii and iv) and pregnancy.

Keywords: extraesophageal symptoms of gastroesophageal reflux disease
effects of incorporating sprouted and non-sprouted chickpea flour in pasta products analyzed in vivo flow-mediated dilation

Conditions: Endothelial Dysfunction

Summary: the investigators examined the effects on post-digestion brachial artery flow mediated dilation (fmd) and in vitro antioxidant capacity of 40% semolina flour replacement with sprouted chickpea flour.

the purpose of the current study was to examine in-vitro and in-vivo effects of replacing 40% of semolina flour with sprouted chickpea flour for the use in pasta. antioxidant capacity in-vitro was measured by trolox equivalent antioxidant capacity. brachial artery flow-mediated dilation, a test of in-vivo endothelial function, was performed for assessment of effects on post-digestion endothelial function. the investigators hypothesized that fmd would be higher after consuming 40% of semolina flour with sprouted chickpea flour pasta vs. 100% of semolina flour pasta.

Eligibility criteria:
inclusion criteria: * healthy adult exclusion criteria: * have diabetes mellitus, kidney disease, a history of cancer, cardiac issues, pulmonary disease, history of a stroke, obesity (for most people this means a body mass index greater than 30), or any life threatening chronic conditions. * food allergies relevant to wheat, gluten, chickpea, and pasta sauce. * are currently being treated for infectious mononucleosis, hepatitis, pneumonia, or other infectious diseases. * are unable or unwilling to refrain from recreational drug (marijuana, cocaine, etc.) or alcohol use during the 24 hours prior to your exercise session. * use nicotine products, or non-contraceptive hormonal therapy (birth control is okay). * are pregnant or trying to become pregnant.
proton pump inhibitor use is associated with high risk of pneumonia in chronic kidney disease patients

Conditions: Chronic Kidney Disease; Pneumonia

Summary: chronic kidney disease is a severe medical problem in taiwan public health issue, which the highest incidence and prevalence rate in the world.proton pump inhibitors may increase the risk of pneumonia appearance, which were caused by profound irreversible gastric acid suppression. the study purpose was to characterize difference of developing pneumonia in chronic kidney disease of prior use proton pump inhibitors.

the study used data from taiwan health insurance research database; the investigators conducted a population-based cohort study in taiwan. case consisted of all patients who had a first diagnosis of chronic kidney disease for the period between 1997 and 2008. the investigators utilized the use of proton pump inhibitor from chronic kidney disease patients.

Eligibility criteria:
inclusion criteria: * chronic kidney disease exclusion criteria: * excluded those patients who had ever been diagnosed with ckd before 1997

Keywords: proton pump inhibitors pneumonia retrospective cohort study
non-interventional study on patients with atrial fibrillation and cancer

Conditions: Atrial Fibrillation; Cancer

Summary: af and cancer frequently coexist. since these patients are usually excluded from randomized trials, information on their management and outcome is scarce. occurrence of relevant clinical events, such as ischemic and hemorrhagic and all-cause mortality and cardiovascular (cv) mortality occurring in patients treated or not with antithrombotic agents needs to be clarified. a prospective observational registry collecting information, in a real world setting, on the clinical profile of patients with these clinical conditions and on the use of antithrombotic drugs in patients with af and cancer could improve our knowledge on the management of these high risk patients.

international, multicenter, non-interventional study on patients with atrial fibrillation (af) and cancer (diagnosed within the last 3 years prior to enrolment). the study will be conducted in about 80 sites in italy and 50 sites distributed in other european countries (belgium, germany, ireland, portugal, spain, the netherlands, turkey). the study will continue till the consecutive recruitment of 1500 patients. the recruitment period will last approximately 24 months. number of visits per patient: baseline and 1 year (final). physicians will not be required to perform any additional tests, assessments, etc., not in line with their routine medical practice.

Eligibility criteria:
inclusion criteria: * both sexes * age \>18 years * patient with diagnosed af (any type of af, electrocardiographically documented within 1 year prior to enrolment) * patient with a documented cancer (diagnosed within the last 3 years prior to enrolment into this registry), including melanoma but not other basal-cell or squamous-cell carcinoma of the skin. the diagnosis/history of cancer must be objectively documented. * written informed consent (ic) for participation in the study * patient not simultaneously participating in any interventional study. exclusion criteria: -
the injury and its consequences in the sports lower limb amputee

Conditions: Leg Lower Amputation; Traumatic Amputation

Summary: this study was motivated by the lack of data in the literature on the injury of the major lower limb amputee playing sports and its socio-professional impact. it aims to study sports-related injuries in lower limb amputees. its objective is to determine the prevalence, but also to describe the injuries (type, location, duration, type of management) and their repercussions in terms of after-effects, and repercussions on sports, professional and personal practice. it also aims to begin a correlation between injury and sports load, type of sport (discipline, practice modality), technical aids used


Eligibility criteria:
inclusion criteria: * lower limb amputee or lower limb agenes * amputee before 55 years old * amputee for more than 2 years * willing to participate in the study * practicing a regular physical activity (at least 1x/week) * patient affiliated or beneficiary of a health insurance plan. * patient aged 18-65 years exclusion criteria: * none

Keywords: sport lower limb amputation
retrospective study to describe the real-world treatment patterns and associated clinical outcomes in patients with metastatic castration-resistant prostates cancer

Conditions: Metastatic Castration-resistant Prostates Cancer

Summary: this is a multi-country, multi-centre, retrospective, non-interventional cohort study planned to include patients diagnosed with mcrpc between 01 january 2016 and 31 december 2018, who have received at least 1 line of treatment (lot) in the mcrpc setting, and have 12 months of follow-up data available.

this is a multi-country, multi-centre, retrospective, non-interventional cohort study planned to include patients diagnosed with mcrpc between 01 january 2016 and 31 december 2018, who have received at least 1 line of treatment (lot) in the mcrpc setting, and have 12 months of follow-up data available.to describe the real-world treatment patterns in patients with mcrpc the data will be collected retrospectively between the date of diagnosis of mcrpc (index date) and the end of follow-up, i.e., until death, the last medical record entry, or the date of data extraction, whichever is the earliest. the data on different types of treatment received by the patients, sociodemographic and clinico-pathological characteristics, and healthcare utilization will be extracted from the medical records of patients (alive or deceased) into a centrally designed electronic data capture system. for the exploratory end point on real-world treatment patterns in patients with mcspc, data on different types of treatment received by the patients, sociodemographic and clinico-pathological characteristics will be retrospectively extracted from the medical records of patients (alive or deceased) into a centrally designed electronic data capture system.

Eligibility criteria:
inclusion criteria: * male patients ≥18 years of age or legal age of being an adult in the country as per local regulations 2. patient or next of kin/legal representative (for deceased patients at study entry, unless a waiver is granted) willing and able to provide written informed consent according to the local regulations 3. patients with a diagnosis of metastatic (stage iv) mcrpc, confirmed by either biopsy of a metastatic tumour site or by history of biopsy-proven localized disease and evidence of metastatic disease on imaging studies (which is clearly noted in hospital/clinical records) and progression on adt alone between 01 january 2016 and 31 december 2018 4. availability of medical records at the participating site reflecting at least one lot received in the mcrpc setting and 12 months of follow-up from the index date (unless the patient died or was lost to follow-up within the first 12 months after diagnosis) exclusion criteria: -1. patients with a concomitant cancer at the time of diagnosis of mcrpc or those who are treated with any anti-cancer therapy indicated for other cancers within 6 months of diagnosis of mcrpc, except for non-metastatic non-melanoma skin cancers or in situ or benign neoplasms. 2. patients unable to give an informed consent (unless a waiver is granted)
effects of legume consumption on adiponectin and inflammatory markers among adults

Conditions: Diabetes Mellitus, Type 2

Summary: the aim of this randomized cross-over study was to determine the effects of legume consumption on adiponectin and inflammatory factors among first degree relatives of diabetic patients


Eligibility criteria:
inclusion criteria: * age more than 30 years * no history of chronic diseases * no use of blood glucose lowering drugs exclusion criteria: * do not use recommended amounts of legumes * incidence of chronic diseases during the study * to start use of blood glucose lowering drugs