Kornimate/medical-research-clean huggingface dataset:
learning disability group art therapy: looking and asking

Conditions: Learning Disability, Adult; Mental Health

Summary: a qualitative study of group art therapy in england for adults with a learning disability accessing community services. different stakeholder views and experiences will be gathered using ethnographically-informed group observation, semi-structured individual interviews and a focus group. people with a learning disability will support the data analysis and dissemination of findings in accessible means.


Eligibility criteria:
inclusion criteria: participants who are art therapists must: * be a hcpc registered arts therapist practicing in the uk * have experience of delivering group arts therapy in a community setting to this population * be able to give informed consent and communicate in english participants who are adults with a learning disability must: * be 18 years old or over * have a diagnosed learning disability or be accessing an nhs specialist learning disability service or using their personal budget to access a third sector art therapy group for this population * have experienced mental distress, have a diagnosed mental health condition or be accessing support for their mental health * be currently accessing group arts therapy * be able to give informed consent with adapted communication aids and approaches to meet their communication preferences * have a level of verbal ability to ensure they can communicate their views and meaningfully engage in the study participants who are paid support staff or family carers must: * be 18 years old or over * be identified by the person with a learning disability as someone who knows them well and could represent the carer perspective in this study * be able to give informed consent * have adequate command of the english to be able to meaningfully engage in the study participants will be excluded if they: * are unable to engage in the informed consent process; this is likely to exclude people who have a more severe form of learning disability * delivering the arts therapy group on an inpatient or acute ward * trainee arts therapists, or those who have yet to complete registration with the hcpc
iron supplementation and side effects

Conditions: Iron Deficiency Anemia; Iron Overload

Summary: the objective of this study is to examine patient-reported gastrointestinal side effects, as well as iron status indicators, inflammatory markers and oxidative stress following administration of ferrous sulfate and iron-enriched aspergillus oryzae supplementation.

iron deficiency anemia (ida) afflicts more than 2 billion people globally, making it the most prevalent nutrient disorder, today. inadequate dietary intake of iron results in consequences like cognitive decline, fatigue, abnormal growth and adverse pregnancy outcomes. these ramifications have associated burdens on economical progression due to decreased market productivity. inorganic iron supplements like ferrous sulfate (feso4) are most commonly used to treat ida, however known associated side effects occur, decreasing compliancy in individuals. moreover, inorganic iron salts present a large bolus of iron to the intestinal lumen, resulting in non-transferrin bound iron which leads to systemic inflammation and further exacerbation of chronic diseases. organic iron compounds have strong potential to be utilized for supplementation, however only under circumstances in which contain high absorbance. seventeen subjects were randomized in a three-armed, double-blinded crossover design to examine the differences among three treatments (feso4, asp-s and placebo). outcomes will be to assess acute inflammatory proteins, oxidative stress, iron status indicators, non-transferrin bound iron and gastrointestinal-related side effects.

Eligibility criteria:
inclusion criteria: * age 18-40 * female * bmi \< 30 kg/m2 * nonsmoker * non pregnant * non lactating * no food allergies to wheat or dairy * no history of gastrointestinal diseases/disorders * willing to discontinue use of vitamin/mineral supplements * no medications that interfere with iron absorption * no blood or plasma donations during study period exclusion criteria: * history of gastrointestinal diseases or disorders * donating blood or plasma two weeks prior to study period * on medications interfering with iron absorption * food allergies to wheat or dairy * pregnant or lactating * smoker * anemic (\< 120 g/l) * ferritin \> 40 ug/l

Keywords: ferrous sulfate non-transferrin bound iron oral iron supplement oral iron supplement side effects
a psychosocial intervention for bereaved spousal caregivers of persons with dementia

Conditions: Dementia; Bereavement

Summary: the purpose of this study is to evaluate the feasibility and acceptability of a writing intervention (reclaiming yourself), intended to facilitate bereavement for spousal caregivers whose partners died with dementia.

the current research is part 3 of a multi-phase project, whose purpose was to examine the experience of bereavement for spousal caregivers to persons with dementia. based on spouses' shared experiences and the input of experts in the field (i.e. bereavement/dementia researchers, health care providers), an existing writing intervention called the finding balance tool was adapted from the context of cancer bereavement to that of dementia. the purpose of this third phase is to test this adapted writing intervention (reclaiming yourself) with bereaved spouses of persons with dementia. participants will be randomly assigned into one of two groups: treatment (who will receive the tool); and control (who will not be offered the tool until a later stage). the feasibility and acceptability of the intervention will be assessed, as well as the degree to which it facilitated participants' bereavement, ability to find balance, and psychological health.

Eligibility criteria:
inclusion criteria: * bereaved for three months or longer * were a caregiver for their spouse with advanced dementia * english speaking * willing and able to share their bereavement experience exclusion criteria: * those with other than a spousal relationship to the person with dementia * spousal caregivers of persons with another terminal disease * those bereaved less than 3 months * those unable to provide consent
ultra-hypofractionated adjuvant radiotherapy ± simultaneous integrated boost for low-risk breast cancer patients

Conditions: Breast Cancer; Radiotherapy Side Effect

Summary: this is a phase ii study to investigate the feasibility of ultra-hypofractionated radiotherapy with or without simultaneous integrated boost for low risk breast cancer patients who have received breast conservative surgery of mastectomy.

during the study, the patients would undergo radiation of 5.2gy for 5 fractions to the prophylactic radiation volumes and and a 6gy per-fraction simultaneous boost to the tumor bed or other high-risk volumes. acute toxicity of grade 2 or higher in the following 12 weeks after radiotherapy is the primary end point.

Eligibility criteria:
inclusion criteria: 1. patients diagnosed with invasive or non-invasive breast cancer; 2. the patients have undergone breast-conserving surgery or mastectomy with axillary sentinel nodal biopsy or dissection; 3. stage ypt0-2n0-1 (if receive neoadjuvant therapy) or stage pt0-2n0-1 (if receive upfront surgery). 4. no distant metastasis; 5. life expectancy ≥6 months; 6. organ function is fine (hemoglobin ≥100g/l, leukocyte ≥2×109/l, neutrophil ≥1×109/l, platelet ≥80×109/l; creatinine 1.5 mg/dl or less; alanine aminotransferase/aspartate aminotransferase ≤2.5×unl.); 7. patients are willing to cooperate to follow up; 8. patients should sign the informed consent; 9. women of childbearing age need effective contraception. exclusion criteria: 1. biopsy proven ipsilateral supraclavicular, infraclavicular or internal mammary nodal involvement. 2. concurrent or previous neuropathy overlapping with the radiation volume or brachial plexus injury; 3. patients who had radiotherapy to the ipsilateral breast, lymph-drainage regions or adjacent areas before; 4. concurrent active connective tissue disease; 5. other malignancies, which affect patient life expectancy (except adequately treated basal cell carcinoma of the skin, carcinoma in situ of the cervix, superficial bladder neoplasms (no more than t1), early stage thyroid carcinoma); 6. severe comorbidities or active disease (poorly controlled heart disease: new york classification of cardiac function ≥ grade 2, active coronary heart disease, unstable angina pectoris, arrhythmia requiring medical treatment/persistent refractory hypertension; myocardial infarction, stroke within six months; poorly controlled diabetes persists. fasting blood glucose ≥ 10mmol/l, 2 hours postprandial blood glucose ≥ 13 mmol/l. poorly controlled psychosis develops or worsens within six months; active infection; positive for antibodies to hiv). 7. pregnant or breast-feeding.

Keywords: breast cancer ultra-fractionated radiotherapy toxicity lymph-drainage region irradiation
construct validity of a large loop excision of the transformation zone (lletz) training model

Conditions: Cervical Dysplasia

Summary: in a prospective case-control study, 140 medical students (,novices') and 10 senior gynecologists (,experts') will perform a large loop excision of the transformation zone (lletz) on a training model afte having undergone a video training session. their lletz-performance will be assessed using an objective structured assessment of technical skills (osats) protocol designed for judging the surgical proficiency when performing a lletz. using metrical and non-metrical data points, construct validity of the lletz training model to distinguish between experts and novices will be assessed. secondary endpoints are differences in osats scores within the group of novices based on gender and handyness, as well as satisfaction of the novices with the learning experience.

in a prospective case-control study, 140 medical students (,novices') and 10 senior gynecologists (,experts') will be included. all participants undergo a video training with demonstration of the lletz procedure on a training model using a sausage as previously described (hefler et al. 2014). after the video training, the lletz procedure will be performed by the study probands and their performance will be assessed using an objective structured assessment of technical skills (osats) protocol with 23 consecutive items. the exact time frame for the assessment of the primary outcome is within 1 hour after the video training. using metrical and non-metrical items, the construct validity of the lletz training model to distinguish between experts and novices will be assessed. the study hypothesis is that the lletz training model as used in this study has construct validity and is therefore a valid instrument to discriminate between experts and novices. secondary endpoints are differences in osats scores within the group of novices based on gender and handyness, as well as satisfaction of the novices with the learning experience.

Eligibility criteria:
inclusion criteria: * medical student * no previous experience with the training model * no previous experience in gynecological surgery exclusion criteria: * language barrier * unwillingness to participate
effect of aerobic exercises and nutrition in adolescent girls with anorexia

Conditions: Anorexia in Adolescence

Summary: randomized control study used to identify the effect of aerobic exercises on the activity of daily living and estradiol serum level in young girls with anorexia

control group will receive diet program while the study group received the same diet program given to control group in addition to aerobic exercise program. inclusive criteria * thirty girls with anorexia * bmi ≤ 18 kg/m2 * age ranged from (14-17 years). * exclusive criteria: * girls did not receive any exogenous steroid and other treatment which could affect plasma levels of estrogen hormone. * exclude any other eating disorders data analysis and statistical design: the collected data will be statistically treated using: descriptive statistics. inferential statistics using: paired t-test.

Eligibility criteria:
inclusion criteria: * thirty girls with anorexia * bmi ≤ 18 kg/m2 * age ranged from (14-17 years). exclusion criteria: girls did not receive any exogenous steroid and other treatment which could affect plasma levels of estrogen hormone.

Keywords: anorexia adolescent girls areobic exercises
impacts of aquatic vs land walking on vascular health and exercise tolerance in patients with peripheral artery disease

Conditions: Peripheral Artery Disease; Vascular Function; Exercise Tolerance; Peripheral Arterial Disease

Summary: the purpose of this study was to examine the impacts of a 12-week aquatic walking exercise program on body composition, vascular function, cardiorespiratory capacity, exercise tolerance, muscular strength, and physical function in patients with peripheral artery disease (pad). the effects of the 12-week aquatic walking exercise program were also compared to the effects of a 12-week land-based walking exercise program.


Eligibility criteria:
inclusion criteria: * peripheral artery disease (ankle-brachial index between 0.6 and 0.9) * 50-85 years of age * sedentary (less than 1 hour of regular exercise participation per week within the previous year) exclusion criteria: * current smoker (smoking within previous 6 months) * psychiatric conditions * pulmonary disease * renal disease * thyroid disease

Keywords: arterial stiffness cardiorespiratory capacity exercise tolerance vo2max
multi-parametric mri assessment of the liver in diabetic volunteers (partners registry)

Conditions: Non-Alcoholic Fatty Liver Disease; Diabetes Mellitus, Type 2

Summary: to build a registry of diabetic volunteers by inviting them to get a livermultiscan and collecting their contact information to seek interest in participating in future research studies.

perspectum's livermultiscan is a quantitative multiparametric mri method, fda-cleared and ce-marked, that is used to detect and stage early liver disease.it is already widely used internally in both research and within the clinical setting. livermultiscan has been adopted as the only liver scan in whole-population long term studies. the livermultiscan is more cost efficient, short in duration(\<15mins), non-invasive and safe(no iv or oral contrast required, no ionizing radiation and no venipuncture). this is a registry where there will be no intervention to the standard of care. registry volunteers will be required to attend a single visit that will involve having a multi-parametric mri at no cost to them. in addition, the investigators will collect contact information of the volunteers including their email address, phone number and home address so that they can be contacted to discuss possible participation in future studies which may be sponsored by perspectum or third parties, such as pharmaceutical companies.the volunteer's personal information shall never be shared with these third parties. additionally, the contact information of the volunteers' medical providers shall also be collected so that the livermultiscan reports can be delivered to them.

Eligibility criteria:
inclusion criteria: * male or female diabetic volunteers aged 18 years and over who are willing and able to give informed consent for participation in the registry. exclusion criteria: * the volunteer may not enter the registry if they have any contraindication to magnetic resonance imaging (standard mr exclusion criteria at the imaging center including pregnancy, extensive tattoos, pacemaker, shrapnel injury, severe claustrophobia).

Keywords: nash fatty liver livermultiscan
diet, physical activity and body composition changes during r-chop

Conditions: Non-Hodgkin Lymphoma; DLBCL; Diffuse Large B Cell Lymphoma

Summary: in this pilot study, observational data will be collected to describe the usual trajectory of changes in dietary intake, ability to be physically active, body composition, environmental exposures, and the gut microbiome over the course of r-chop treatment for non-hodgkin lymphoma (nhl).

rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (r-chop) is the "gold standard" first-line treatment for patients with non-hodgkin lymphoma, yet it is estimated that r-chop is not curative for 30- 50% of patients. preliminary studies suggests that modifiable lifestyle factors such as body composition, exposure to endocrine disrupting chemicals, and changes in the gut microbiome may contribute to variation in r-chop treatment response. if true, it could be possible to modify these factors in an effort to improve treatment outcomes, however more detailed information is needed to confirm these preliminary findings and test whether lifestyle modification can improve outcomes. in this observational study, data will be collected on dietary intake, ability to be physically active, body composition, environmental exposure to endocrine disrupting chemicals and changes in the gut microbiome over the course of r-chop for nhl. the study will provide more detailed information on the usual trajectory of these lifestyle factors during r-chop treatment than has previously been collected, especially how these factors co-vary over time. the study findings are expected to inform future intervention studies aimed at improving r-chop treatment outcomes.

Eligibility criteria:
inclusion criteria: * diagnosis of one of the non-hodgkin lymphomas * scheduled to receive r-chop at the george washington university cancer center exclusion criteria: * diagnosis of cancer other than one of the non-hodgkin lymphomas * patients who are scheduled to receive their r-chop somewhere other than the george washington university cancer center * patients who are not competent to provide informed consent to participate

Keywords: diet physical activity body composition bisphenol phthalate gut microbiome
different dosage of decompression therapy on symptoms of lumbar radiculopathy

Conditions: Lumbar Radiculopathy

Summary: this study will provide evidence about how much dose of decompression more effective for the treatment of lumbar radiculopathy. as this hypothesis has no evidence about the dosage of decompression in literature till now.

decompression therapy differs from traction-based therapy in that the traction applied to the spine in decompression therapy is typically alternated between lower and higher levels of tension for predetermined periods of time. in either therapy, spinal tension is maintained for the period's typically extending 30-minutes or longer. this study will provide evidence about how much dose of decompression more effective for the treatment of lumbar radiculopathy. as this hypothesis has no evidence about the dosage of decompression in literature till now.

Eligibility criteria:
inclusion criteria: * both genders * age between 30 to 50 years * unilateral radiculopathy * limited slr (less than 60 degree) * pain on numeric pain rating scale \< 7 * bmi ≤ 30 exclusion criteria: * severe paraspinal muscle spasm * acute prolapse intervertebral disc * bilateral positive slr * osteoporotic * h/o spinal fracture

Keywords: pain radiculopathy lumbar decompression
acupuncture in adolescent football players

Conditions: Acupuncture Therapy; Sports Medicine

Summary: is it feasible to perform acupuncture in the training field after sport performance in adolescent football players? does acupuncture provide a decrease in muscle soreness and improvement in overall sense of well-being in the adolescent football population?

previous studies on the effects of acupuncture on performance and post-exercise recovery have shown that it reduces perceived pain arising from exercise induced muscle soreness and reduces muscle spasm. acupuncture has also been shown to serve as an adjunct to improve muscle strength training and to accelerate recovery from workouts and injury. the investigators' goal is to study approximately 50 high school football players in their true pre-season warm weather training environment. the investigators will measure the effects of acupuncture treatment on muscle soreness and overall sense of well-being by administering pre- and post-treatment surveys. athletes will undergo five treatment sessions over the course of 2.5 weeks. the treatments will be performed by licensed acupuncturists employed at mayo clinic. the study has been approved by the institutional review board at the mayo clinic.

Eligibility criteria:
inclusion criteria 1. male or female members of the two local high school football teams 2. age 13-18 years 3. no current musculoskeletal injuries 4. generally healthy individuals who plan to complete the season barring injury or other unexpected events. exclusion criteria: 1. acupuncture treatment within the past year 2. known active musculoskeletal injury or condition, immunocompromised state, prosthetic heart valve, pregnancy or known history of bleeding disorder.
the influence of psychological interventions upon disease progression in hiv-infected patients receiving no medication

Conditions: HIV Infected Individuals

Summary: this study examines the hypothesis that psychological interventions have beneficial effects on quality of life including psychological well-being and disease progression in early hiv patients recieving no medication.

hypothesis: this investigation is based upon the hypothesis that psychological intervention may counteract the detrimental effects of stress both on psychological well-being and on general health. background: hiv infection may be considered to be a life-long biological and psychological stressor leading to detrimental outcomes associated with disease progression. stress reduction in these patients may have beneficial effects through delaying disease progression via the proposed interactive psycho-neuro-endocrine-immune network. inclusion criteria: hiv infected individuals cd4 t-cell counts above 200 cells/mcl receiving no anti-retroviral drugs individuals who signed the informed consent form investigative approach: self-hypnosis and a japanese non-touching, laying-on-of hands-like technique, called johrei, were used to investigate the effects of psychological intervention upon immune parameters (especially in cd4 counts) associated with disease progression along with phenomenological associations between stress perception and stress hormone levels in hiv-infected patients receiving no medication.

Eligibility criteria:
inclusion criteria: * hiv infected * cd4 t-cell counts above 200 cells/mcl * signed the informed consent form exclusion criteria: * receiving anti-retroviral drugs

Keywords: hiv stress psychoneuroimmunology stress management hypnosis johrei psychological intervention