locally delivered metformin & rosuvastatin for treatment of intrabony defects in chronic periodontitis

Conditions: Chronic Periodontitis

Summary: metformin (mf), a biguanide group of anti-diabetic drug has been shown to enhance osteoblasts differentiation and inhibit osteoclast differentiation in vitro, thus may exhibit a favourable effect on alveolar bone. statins are one of the lipid lowering drugs that help in reducing cholesterol levels in the body by specifically inhibiting 3-hydroxy-3-methylglutaryl coenzyme a reductase; which is a rate limiting enzyme for cholesterol synthesis. rosuvastatin (rsv) have shown to have bone stimulatory and anti-inflammatory effects.statins are one of the lipid lowering drugs that help in reducing cholesterol levels in the body by specifically inhibiting 3-hydroxy-3-methylglutaryl coenzyme a reductase; which is a rate limiting enzyme for cholesterol synthesis. rosuvastatin (rsv) and atorvastatin (atv) have shown to have bone stimulatory and anti-inflammatory effects.. the present study aims to explore the efficacy of 1.2% rsv and 1mf gel as a local drug delivery and redelivery system as an adjunct to scaling and root planing (srp) for the treatment of intrabony defects.

metformin (mf), a biguanide group of anti-diabetic drug has been shown to enhance osteoblasts differentiation and inhibit osteoclast differentiation in vitro, thus may exhibit a favourable effect on alveolar bone. statins are one of the lipid lowering drugs that help in reducing cholesterol levels in the body by specifically inhibiting 3-hydroxy-3-methylglutaryl coenzyme a reductase; which is a rate limiting enzyme for cholesterol synthesis. rosuvastatin (rsv) have shown to have bone stimulatory and anti-inflammatory effects.statins are one of the lipid lowering drugs that help in reducing cholesterol levels in the body by specifically inhibiting 3-hydroxy-3-methylglutaryl coenzyme a reductase; which is a rate limiting enzyme for cholesterol synthesis. rosuvastatin (rsv) and atorvastatin (atv) have shown to have bone stimulatory and anti-inflammatory effects.. the present study aims to explore the efficacy of 1.2% rsv and 1mf gel as a local drug delivery and redelivery system as an adjunct to scaling and root planing (srp) for the treatment of intrabony defects. methods: ninety patients with intrabony defects were randomly allocated into three treatment groups: srp plus placebo gel (group 1), srp plus 1.2% rsv gel (group 2) and 1% mf gel (group3). clinical and radiographic parameters were recorded at baseline then after 6 months. the gels were delivered at the respective sites at baseline . then again all clinical and radiographic parameters were recorded after 6 months and 12 months.

Eligibility criteria:
inclusion criteria: - all the subjects were systemically healthy subjects with sites having cal ≥ 3 mm, ppd ≥ 5 mm, vertical bone loss ≥ 3 mm on intraoral periapical radiographs (iopa) and subjects with no history of periodontal intervention in the last 6 months. exclusion criteria: patients with systemic diseases like cardiovascular disease diabetes or hiv infection or on medications like corticosteroids which may impede the healing in periodontal tissues. pregnant/lactating females tobacco users alcoholics patients with unsatisfactory oral hygiene (plaque index greater than 1.5) teeth having gingival recession, caries involving pulp, intrabony defect present interproximally, grade 2/3 mobility furthermore, patients allergic to metformin and rosuvastatin or those taking metformin and rosuvastatin systemically were excluded. -