Kornimate/medical-research-clean huggingface dataset:
combining left atrial appendage closure with cryoballoon ablation in chinese population

Conditions: Atrial Fibrillation

Summary: cryoablation combined with left atrial appendage closure is a novel strategy for atrial fibrillation patients. through long-term follow-up, the investigators aimed to observe the safety and efficacy of the combined procedure in chinese population.

the investigators aimed to observe the clinical outcome of combining cryoballoon ablation (cba) with left atrial appendage closure (laac) in drug-refractory non-valvular atrial fibrillation patients, who have high risk of stroke or hemorrhage, or contraindication of long-term oral anticoagulants (oacs). the combined procedure was completed using cba following laac. generally, 3-month oacs, following 3-month double antiplatelet therapy, and lifelong single platelet therapy was recommended as antithrombotic regimen. at 3rd,6th,12th and every year after since the procedure, holter and transoesophageal echocardiography monitoring, and outpatient follow-up was applied to every patient. the safety was evaluated by all-cause mortality, peri- and postprocedural complications. while the efficacy was evaluated through the freedom of atrial arrhythmia, stroke incidence, and withdrawal of oacs.

Eligibility criteria:
drug refractory non-valvular paroxysmal atrial fibrillation patients, inclusion criteria: 1. cha2ds2-vasc score≥2 or has-bled score≥3, 2. having contraindications to long-term oral anticoagulants (oacs), 3. refuse oac therapy despite explanation. exclusion criteria: 1. thrombus in left atrium (la) or left atrial appendage (laa) presented and confirmed by transoesophageal echocardiograph (tee), 2. oversized la (la diameter\>65mm by tte) or laa (laa opening\>35mm) through tee, 3. pericardial effusion (≥4mm by tte or tee), 4. hemodynamic unstable patients, 5. patients with active hemorrhagic diseases, 6. ischemic or hemorrhagic stroke within 30 days.

Keywords: combined procedure cryoballoon ablation left atrial appendage closure chinese
demonstrating the diagnostic power of an electronic nose: study on exhaled air samples

Conditions: Alzheimer Disease; Gastric Cancer; Urologic Cancer; Pneumological Cancer

Summary: the investigators don't know yet how the nose and the brain decode the smells. scientific studies in neuroscience have shown that people who have tumors may have changes in the smell of secretions. dogs are extremely efficient at detecting these changes, even before imaging studies. a review of the recent literature shows the different work done on the diagnosis of dogs on human pathologies, especially oncology. it is now known that the smell of exhaled gases is representative of the intestinal biotope and that a large number of pathologies are related to the type of microbial populations that inhabit the intestines. copying the olfactory organs could thus be of major interest for the early diagnosis of pathologies. more and more works are interested in the diagnostic power of electronic noses. from a technical point of view, these are nano-sensors that mimic the olfactory receptors from the breath gas of the subjects. they analyze the molecules present and compare them with a database to establish a diagnosis according to a probabilistic algorithm. the use of exhaled air for the diagnosis of cancerous pathologies has already been the subject of scientific work. a classification using the svm (support vector machine) method using data from 320 sensors made it possible to differentiate patients with lung cancer from controls in 98.8% of cases. the differential diagnosis of obstructive bronchopneumopathy was also very well done in this same study. another study shows equally encouraging results, highlighting sensitivities and specificities above 80%.


Eligibility criteria:
inclusion criteria: * the patient must have signed the free and informed consent form or their guardian if applicable. if the state of health of the patient does not allow him to give and sign his consent, it will be sought from the person of trust * the patient must be an affiliate or beneficiary of a health insurance plan * the patient is at least 18 years old exclusion criteria: * the patient participates or has participated within 3 months in another study that may have modified their intestinal biotope * the patient is in an exclusion period determined by a previous study * the patient is under the protection of justice * the patient or guardian or trusted person refuses to sign the consent * the patient does not read the french language fluently * the patient claims to be pregnant * the patient is breastfeeding
congenital or idiopathic complete right bundle branch block: physiological significance and molecular characterization

Conditions: Bundle-Branch Block

Summary: this study is to determine 1) the incidence of altered right bundle conduction, including crbbb, irbbb or rsr' pattern in the taipei city based on the school survey databank from 1999 to 2002, 2) the associated cardiac lesions, 3) clinical presentations relevant to the altered right bundle conduction, 4) the association with qtc prolongation and dispersion and hrv from a 5-minutes recording. finally, molecular characterization for those with crbbb or brugada pattern ekg, especially those with positive family history will be studied.

the ekg pattern and medical records from the school survey from 1999 to 2002 in taipei city will be reviewed, and the basic data of those with crbbb, irbbb and rsr' pattern will be recorded. interview will be made and the echocardiographic measurements will be performed to identify associated cardiac defects. ekg parameters and qt, qtc, qt dispersion, qtc dispersion and hrv parameters will be obtained from a semi-automated system. time domain and frequency domain measures will be calculated and expressed as sdnn, triangular index, sdnn index, total power, low frequency power and high frequency power. mutational analysis and dna sequencing will be conducted in those with crbbb or brugada pattern ekg, especially those with positive family history. based on these data, the clinical significance of altered bundle branch conduction identified from a school survey may be defined. for those with isolated crbbb or irbbb, the adjunctive value of hrv and qt parameters will determined the high risk group, and 24 hour holter recording and treadmill exercise test will then perform in these patients to define association with ventricular arrhythmia.

Eligibility criteria:
inclusion criteria: * ecg showed right bundle branch block exclusion criteria: * can't tolerate treadmill ecg study

Keywords: right bundle branch block electrocardiography ion channel
clinical study of human umbilical cord mesenchymal stem cells in the treatment of premature ovarian insufficiency

Conditions: Premature Ovarian Insufficiency

Summary: this study was a single-center, randomized, controlled prospective study. those who had premature ovarian failure and who had fertility requirements were enrolled in the study. to determine the efficacy and safety of umbilical cord mesenchymal stem cells in the treatment of patients with poi.

according to the enrollment and exclusion criteria, the patients were enrolled, and the subjects were randomly divided into two groups by computer randomization. group a was hormone replacement combined with transplantation of umbilical cord mesenchymal stem cells (test group). group b was the hormone replacement group (control group).

Eligibility criteria:
inclusion criteria: 1. those who meet the pof diagnostic criteria and have no spontaneous follicular activity; 2. married, 20 years old ≤ age \< 40 years old; 3. the average diameter of each ovary is \> 10 mm; 4. have agreed to sign the informed consent form. exclusion criteria: 1. female and/or male chromosomal abnormalities; 2. endometriosis, adenomyosis; 3. postoperative ovarian borderline or malignant tumor; 4. uterine dysplasia; 5. associated with female autoimmune disease or other serious internal surgical diseases; 6. hormone replacement contraindications; 7. in the past 1 year, had received an experimental study of premature ovarian failure in the external hospital; 8. male azoospermia or severe oligozoospermia.
dose-finding for dobutamine during transitional circulation in very preterm infants

Conditions: Infant, Premature, Diseases; Circulatory and Respiratory Physiological Phenomena

Summary: single centre, dose finding trial to establish the minimum effective dose of dobutamine required to treat hemodynamic insufficiency, defined as low superior vena cava (svc) flow, in infants below 33 weeks' gestation during transitional circulation (first 72 hours from birth).


Eligibility criteria:
inclusion criteria: * born with up to 32(+6) weeks gestation * presence of hemodynamic insufficiency, defined as svc flow \<51 ml/kg/min. * provision of signed and dated informed consent form by father/mother or legally designated representative, which can be given antenatally. exclusion criteria: * neonates considered non-viable, with a clinical decision not to provide life support * infants with severe congenital hydrops fetalis needing chest or peritoneal drainage before recruitment * infants already on dobutamine treatment * infants with congenital malformations likely to affect cardiovascular adaptation (including: congenital diaphragmatic hernia, gastroschisis or congenital heart defects) * infants with chromosomal anomalies * lack of parental signed informed consent

Keywords: hemodynamic insuffiency low superior vena cava flow
the role of cathepsin x in infection with the helicobacter pylori

Conditions: Persistence of Infection With Helicobacter Pylori

Summary: the immune response to helicobacter pylori (hp) importantly determines the pathogenesis of infection as well as the success of antibiotic eradication of the bacteria. the investigators want to demonstrate the importance of cathepsin x (ctsx), a cysteine protease, for the hp eradication success. the diversity of the innate immune response to h. pylori antigens leading to either successful eradication of the infection or maintenance of chronic inflammation is connected to ctsx. the aim of this study is to determine whether h. pylori suppresses the ctsx expression and cytokine secretion in macrophage cell line thp-1 in the individuals that are not capable of eradicating the infection, opposite to h pylori in patients with successful h pylori eradication . the investigators also investigate the possibility whether strain-dependent differences in h. pylori lipopolysaccharide (lps) influence the ctsx expression and cytokine secretion.


Eligibility criteria:
inclusion criteria:people with helicobacter gastritis and helicobacter sensitive to antibiotic therapy but failure of therapy - exclusion criteria:people with helicobacter gastritis who did not eradicate helicobacter pylori because of primary resistance to antibiotics. -

Keywords: helicobacter pylori eradication failure
assessment of hypotonia in children with down syndrome

Conditions: Muscle Hypotonia; Down Syndrome; Muscle, Floppy; CHILD Syndrome; Infant Floppy

Summary: hypotonia is a common trait in infants with down syndrome, resulting in pathologies and delays in gaining basic motor skills. there are no screenings available to aid in early diagnosis, therefore, the purpose of this study is to develop a way to test for hypotonia in children with down syndrome.

hypotonia is usually diagnosed by observation and clinical assessment. aiming to develop an instrument for early diagnosis, a systematic review was carried out which compiled characteristics and testing that are attributed to or used in the diagnosis of hypotonia. they were presented as an item group and a first stage was created and administered to 50 children with down's syndrome between the ages of 7 months to 8 years old. the study of the results showed which characteristics were really related to the convention and which were more affected by changing factors. then a final scale was developed that met the expected requirements of validity and reliability.

Eligibility criteria:
inclusion criteria: * volunteer parents who have infants with down syndrome between the ages of 7 months to 8 years old exclusion criteria: * other hypotonic syndromes
a study to compare the safety and effectiveness of two dosing schedules of lamivudine in combination with two other anti-hiv drugs

Conditions: HIV Infections

Summary: the purpose of this study is to compare the safety and effectiveness of 2 dosing schedules (once daily vs twice daily) of lamivudine (3tc) given with stavudine (d4t) and either indinavir (idv) or nelfinavir (nfv) for 24 weeks.

patients are randomized to 1 of 2 groups. group 1 receives 3tc qd plus d4t plus either idv or nfv. group 2 receives 3tc bid plus d4t plus either idv or nfv. patients are evaluated for drug tolerance, medication adherence, and genotypic and phenotypic resistance.

Eligibility criteria:
inclusion criteria patients may be eligible for this study if they: * are hiv-positive. * are at least 18 years old. * have had an hiv level below 400 copies/ml for at least 3 months prior to study entry. * have a cd4 cell count of at least 50 cells/mm3. * are currently taking an anti-hiv drug regimen that includes 3tc plus d4t plus either idv or nfv for at least 6 months prior to study entry. (note: this must be their first anti-hiv drug regimen.) * agree to abstain from sex or use effective methods of birth control during the study. exclusion criteria patients will not be eligible for this study if they: * have a history of an aids-defining illness or certain other medical conditions. * are allergic to any of the study drugs. * are unable to take medication by mouth for any reason. * have received certain medications. * will need to receive radiation therapy or chemotherapy (for any cancer other than kaposi's sarcoma) during the study. * are pregnant or breast-feeding.

Keywords: drug therapy, combination zidovudine drug administration schedule stavudine hiv protease inhibitors lamivudine indinavir dosage forms nelfinavir reverse transcriptase inhibitors anti-hiv agents
kintsugi voice device study

Conditions: Depression, Anxiety

Summary: the kintsugi voice device pilot study is a two arm pilot diagnostic accuracy study. eligible enrolled participants will complete the patient health questionnaire-9 (phq-9) and generalized anxiety disorder-7 (gad-7) instruments, as well as complete a remote video-recorded structured clinical interview for the diagnostic and statistical manual for mental disorders-5 (scid) with a trained psychiatrist. this study seeks to evaluate the ability of the device to aid clinical assessment for depression and anxiety by comparing its output with the established diagnostic standard consisting of a diagnosis made by a specialist clinician based on dsm-5 criteria. the order of the assessments will be randomized. audio captured during the scid interview will be inputted into a machine learning model to determine the diagnostic accuracy of the kintsugi voice device.

this is a prospective study of up to 100 subjects, ages \>22 years of age. the study is striving for a 50%/50% split of subjects who have depression and/or anxiety and subjects who do not have depression and/or anxiety.

Eligibility criteria:
inclusion criteria: * subjects greater than or equal to 22 years of age at the time of informed consent * participants must be able to read, understand, and sign the informed consent form * access to a laptop, smartphone, tablet, or other device with a functioning microphone * participants must be willing to be videotaped as part of the study * stated willingness to comply with all study procedures and availability for the duration of the study * fluency in english * availability for the duration of the study * the participant must reside within the state of california exclusion criteria: * any impairment that would prevent participants from completing an online survey and/or engage in clinician assessment interviews (e.g., visual impairment, motor impairment, hearing impairment, acute intoxication) * any known history of neurodegenerative or central nervous system disorders * any known history of schizophrenia, psychosis, or severe cognitive deficits * any known presence of disorders that may lead to false signal of depression or anxiety including multiple sclerosis, amyotrophic lateral sclerosis, parkinson's disease, stroke, traumatic brain injury * presence of voice disorders that may impact vocal cords such as acute or chronic laryngitis, vocal cord paresis or paralysis, or spasmodic dysphonia * any known history of vocal cord injury or cerebrovascular accident or head trauma with residual dysarthria in the past year * past or active heavy smokers if there is impact on the vocal cords * any known history of congenital deafness * subjects who do not speak english * subjects who do not live in the united states * subjects who have previously participated in any kintsugi-sponsored study

Keywords: mental health depression anxiety remote research artificial intelligence diagnostic
localization of parathyroid adenoma by fluorocholine pet/mri (positron emission tomography -mri)

Conditions: Primary Hyperthyroidism

Summary: a comparative prospective study to evaluate different imaging modalities (pet-ct and pet-mr) prior to surgery in parathyroid tumor patients.

patients with hyperthyroidism and surgery indication will be recruited and directed to imagine exams. in addition to the conservative 99mtc-mibi (methoxyisobutylisonitrile) and us, patients will also undergo 18fch (¹⁸f-choline) pet/mri for detecting adenomas and their location. imaging experts will decode the imaging exams. sensitivity and specificity of the exams will be examined.

Eligibility criteria:
inclusion criteria: patients who meet the criteria accepted in the world health organization (who) analysis: * symptomatic patients (constipation, depression, peptic ulcer, pathologic fractures, chronic fatigue, pain from a urinary tract stones etc..) or at least one of the following criteria: * blood calcium levels above 1 more than normal * creatinine clearance decreased in 30% from age expected * urine creatinine above 400 mg in 24 hours exclusion criteria: * patients with hyperthyroidism secondary and tertiary (secondary to kidney disease) * patients who are not eligible to sign an informed consent * pregnant women * patients with sensitivity (allergy) technetium or 18fch

Keywords: positron emission tomography-magnetic resonance imaging (pet-mr) hyperthyroidism positron emission tomography-computed tomography (pet-ct)
prevention of pressure ulcers in patients at high risk of developping pressure ulcers using the low-pressure motorized air support mattress with xtech®25 control unit

Conditions: Pressure Ulcer

Summary: the aim of the study is to determine the clinical value of using a a low air pressure motorised therapeutic mattress in the prevention of pressure injury (pi) in patients at medium to high risk. this study is noncomparative, observational study. patients older than 18 years of age, with a high risk of pi, without pi, lying more than 20 hours a day on a xtech®25 mattress will be included. the study will be conducted in nursing homes, and in long-stay geriatrics department. patients are followed up for 35 days. the use of the xtech®25 mattress is associated with the usual pi prevention measures. the primary outcome is the percentage of patients who developed between day 0 and day 35 at least one pi of at least stage 2 on the sacrum, spine, or heel. secondary endpoints are patient assessments of comfort, caregiver satisfaction, mattress noise level, and mattress safety.


Eligibility criteria:
inclusion criteria: * patient over 18 years old * patient with high risk of developing pressure ulcers (clinical judgment and a score \<= 12 on the braden scale (6 (maximum risk) to 23 (no risk)) * patient without pressure injury on the day of inclusion * patient up lying more than 20 hours a day on xtech®25 mattress * patient with a weight \< 200 kg * patient (or a trusted third party) having been informed of the study and agreeing to participate exclusion criteria: * patient at end of life (estimated life expectancy less than 6 months) * patient discharge from the establishment expected within two months * participants will be excluded from the study if they meet the following combination of criteria indicative of malnutrition according to the 2021 haute autorité de la santé guidelines (participants must meet at least one phenotypic criterion and one etiological criterion to be considered malnourished and therefore ineligible for inclusion in the study) : a) one or more of the following phenotypic criteria: 1. significant unintentional weight loss: a weight loss of ≥ 5% within 1 month or ≥ 10% within 6 months 2. low body mass index (bmi): bmi \< 18.5 kg/m² for individuals under 70 years old, bmi \< 21 kg/m² for individuals aged 70 years and older 3. reduced muscle mass 4. evident reduction in muscle mass and b) one of the following etiological criteria: 1. inadequate nutritional intake: 2. nutritional intake less than 50% of the energy requirements for more than one week 3. reduced food intake for more than two weeks 4. presence of disease or stress metabolism 5. acute or chronic illness, or any condition causing metabolic stress that increases energy requirements .

Keywords: prevention pressure ulcer low air pressure motorised mattress
virtual reality in people with persistent postural-perceptual dizziness

Conditions: Vestibular Dizziness

Summary: this study aimed to compare the effectiveness of virtual reality (vr) and vestibular rehabilitation therapy (vrt) in enhancing balance in individuals with persistent postural-perceptual dizziness (pppd). the experimental group received vr combined with vrt and optokinetic stimulation, while the control group received vrt and optokinetic stimulation. the study involved 42 individuals diagnosed with pppd and administered ten intervention sessions over six weeks. the study also examined the impact of vr on various aspects of pppd, including dizziness, visual vertigo, mental well-being, sleep quality, fall risk, and overall quality of life.

persistent postural-perceptual dizziness (pppd) represents a relatively new vestibular diagnosis that has garnered recent attention within the medical community. consequently, there exists a pressing demand for efficacious and innovative management strategies. the primary purpose of this study was to assess the comparative effectiveness of virtual reality (vr) versus vestibular rehabilitation therapy (vrt) in enhancing balance among individuals afflicted with pppd. a secondary purpose encompassed an investigation of vr's impact on various dimensions of pppd, including dizziness, visual vertigo, mental well-being, sleep quality, fall risk, and overall quality of life. materials and methods: a cohort comprising forty-two individuals conclusively diagnosed with pppd was randomly assigned to two distinct groups. the experimental cohort comprised twenty-one participants subjected to a combination of vr with optokinetic stimulation alongside vrt, whereas the control group, also consisting of twenty-one individuals, underwent solely optokinetic stimulation paired with vrt. the intervention sessions were administered twice weekly over a span of six weeks, resulting in a total of ten intervention sessions. additionally, baseline and post-intervention assessments were conducted to gauge the efficacy of the interventions.

Eligibility criteria:
inclusion criteria: * patients with a confirmed diagnosis of the pppd from a specialized physician, based on the diagnostic criteria published by the barany society. * patients who scored more than 27 on the niigata pppd questionnaire (npq) exclusion criteria: * if they suffered from other neurological or orthopedic deficits that affected their balance and prevented them from moving independently.