Kornimate/medical-research-clean huggingface dataset:
effectiveness of a cell phone-based program for abstinence and hiv risk prevention

Conditions: HIV Infections

Summary: this study will develop and test the effectiveness of a cell phone-based text messaging program to encourage abstinence, monogamy, or condom use among black urban males in philadelphia, pennsylvania.

sexually transmitted diseases (stds), including hiv infections, are most commonly spread through unprotected sexual intercourse. stds are a primary health issue, especially among young ethnic minorities in the united states. the rate of stds is significantly greater in urban areas where ethnic minorities, particularly african-american males, are commonly represented. despite this information, safe sexual practices, including correct condom use, are not commonly followed among minority males. it is believed that educational outreach designed to motivate and inform on the correct use of condoms will be effective in encouraging safer sex practices. a cell phone-based text messaging program designed to promote safer sex practices may provide an effective and easy means of delivery of treatment. this study will develop and test the effectiveness of a cell phone-based text messaging program to sustain abstinence, monogamy, or condom use among black urban males in philadelphia, pennsylvania. participation in this study will be divided into two phases. in the first study phase, participants will partake in a 90-minute focus group to help develop text message content and plans for treatment delivery. the next study phase will be a pilot test of the program developed in the first phase. participants will be assigned to receive text messages concerning either hiv prevention or general nutrition. participants receiving the hiv prevention text messages will be sent up to 90 text messages related to abstinence, monogamy, and condom use over a 3-month period. participants will also be able to join interactive phone activities related to hiv. participants receiving the nutritional text messages will be sent up to 30 messages about nutrition and healthy eating over the same period of time. participants will complete telephone surveys at baseline and months 3 and 6. the surveys will assess measures of abstinence, monogamy and condom use attitudes, norms, self-efficacy, and risk behaviors.

Eligibility criteria:
inclusion criteria: * resident of philadelphia * self-identified black or african american * english-speaking * cell phone user

Keywords: hiv prevention mobile phone technology-based intervention hiv hiv seronegativity
a multicenter trial of a topical medication for papulopustular rosacea applied twice daily versus once daily

Conditions: Papulopustular Rosacea

Summary: to assess the efficacy and tolerability of azelaic acid 15% gel applied once daily versus twice daily in the treatment of patients with papulopustular rosacea.

to test the efficacy and safety of once vs twice daily application of azelaic acid 15% gel on papulopustular rosacea

Eligibility criteria:
inclusion criteria: - papulopustular facial rosacea; minimum of 10, maximum of 50 inflamed papules and/or pustules exclusion criteria: * mild or severe rosacea * rosacea with marked ocular manifestations * presence of dermatoses that could interfere with the rosacea diagnosis or evaluation of the study course * wash out period required for patients treated prior to study with topical retinoids, oral antibiotics, topical antibiotics, systemic and topical corticosteroids, topical imidazole, laser surgery for telangiectasia * history of hypersensitivity to propylene glycol
comparison of hyaluronic acid, prp and steroid injections in partial rotator cuff tears: a prospective randomized study

Conditions: Partial Tear of Rotator Cuff; Rotator Cuff Tears

Summary: there are many conservative treatment options available for partial rotator cuff tears. however, the superiority of a certain type of injection could not be demonstrated with the available data. our aim is to compare the effectiveness of steroid, hyaluronic acid, prp and placebo (normal saline) injections in partial rotator cuff tears by applying the same physical therapy protocol after injection.


Eligibility criteria:
inclusion criteria: * persistent continous pain at least 3 months * partial thickness rotator cuff tear on mri exclusion criteria: * inflammatory disease * pregnancy * known malignancy * bleeding disorder ( or \<10 g/dl hb level, \<150.000 ul platelet) * previous shoulder injection * history of shoulder surgery * full-thickness tear * other shoulder problem (osteoarthritis, bony lesions, etc)

Keywords: partial rotator cuff tear subacromial injection plateled-rich-plasma physical therapy
study to evaluate the safety and efficacy of androxal™ treatment in men with secondary hypogonadism

Conditions: Secondary Hypogonadism

Summary: approximately 4 to 5 million men in the u.s. are testosterone-deficient. enclomiphene (trans-clomiphene) citrate (androxal) was evaluated to determine if androxal increased serum testosterone levels in men with secondary hypogonadism. subjects were randomly assigned to 1 of 4 treatments groups. appropriate amounts of medications were dispensed at each visit. subjects took their medications orally or by rubbing it onto the skin (depending on the treatment assignment) once daily for up to 6 months. treatment visits occurred at approximately 4-week intervals for months 1, 2, and 3 and then at 6-week intervals for months 4, 5, and 6.


Eligibility criteria:
inclusion criteria: * total serum testosterone concentrations \< 300 ng/dl at baseline exclusion criteria: * presence or history of prostate cancer * elevated psa \> 3.5 ng/ml additional inclusion and exclusion criteria may apply.

Keywords: secondary hypogonadism
comfort talk and economic outcomes in mri

Conditions: Claustrophobia; Complication of Diagnostic Procedure

Summary: annually, an estimated 700,000 patients do not complete their scheduled mri scans because of claustrophobia or inability to hold still. training staffs working in mri facilities to provide comfort talk® will enable patients to complete high quality imaging without medication, which will increase satisfaction and comfort while reducing sedation risks for patients, and increase efficiency and reduce loss of revenue for facilities. the effect of such training will be tested at 12 mri sites in a randomized design. outcome data will be collected for one year.

claustrophobia and disruptive patient motion are common impediments to mri examination, but they may be prevented or ameliorated with a non-pharmacologic behavioral intervention administered by trained staff. the potential benefits of such an intervention are highly significant, considering that the alternatives are to cancel the study or administer sedation. inability to complete their mri scans adversely affects an estimated 700,000 patients every year in the us. these patients are either deprived of a diagnosis, subject to diagnostic delays and interpretation errors due to motion artifact, or are exposed to risks of pharmacologic sedation, including death. the imaging facilities typically cannot fill the suddenly vacated examination slots in time before the next scheduled patient and incur considerable lost revenue and efficiency. a negative patient experience further jeopardizes value-based reimbursement by the centers for medicare and medicaid services (cms) towards which patient satisfaction counts 30%. the long term goal is to provide a validated, clinically feasible means for non-pharmacologic amelioration of claustrophobia and disruptive patient motion, achieved by training facility staff in comfort talk®. comfort talk® training consists of a proprietary, standardized r3 process of rapport, relaxation, and reframing including 2 x 8-hrs class-room interaction, onsite coaching, and institution-specific web-based support to help the mri team to further develop its own language style and skill set. the effect of comfort talk® training will be quantified in a prospective randomized design at 12 mri satellites of the ohio state university medical center and duke university medical center. return of investment of training will be based on a decision-analysis model with focus on number of scans performed, cancellations from no-shows and refusals; patients unable to start or complete a scan; and sedation rates in relation to capacity, cost, and reimbursement schedule. patient satisfaction scores will be compared using press ganey national benchmark percentile rankings and cms quality standards.

Eligibility criteria:
inclusion criteria: * must routinely perform mri examinations * must capture data on noncompletion of mri scans exclusion criteria: * no dedicated mri unit * unable to reliably capture data on noncompletion of mri scans

Keywords: magnetic resonance imaging patient satisfaction diagnostic imaging
investigation of the effect of pilates exercises on patellofemoral pain

Conditions: Patellofemoral Pain

Summary: this study aimed to investigate the effectiveness of pilates exercises in patellofemoral pain patients compared to hip and knee combined exercises in improving pain, muscle strength, flexibility, function and quality of life in short term.

patellofemoral pain is a common condition characterized by pain in anterior knee, around the kneecap. it is known that exercise is beneficial in rehabilitation in general. exercise programs applied to patients with pfp should include hip and knee-targeted combined exercises. nowadays, pilates is used as an effective rehabilitation tool for individuals with musculoskeletal problems, especially in reducing pain and improving function. therefore, we believe that pilates exercises can be effective in pfp considering that pfp is a chronic condition and exercise therapy is one of the main strategies in the treatment. pilates may be preferred as one of the alternative treatment method. this randomized controlled study was designed to compare the effects of two different treatment protocols, group-i (supervised rehabilitation) and group-ii (pilates exercises). patients who applied to the istanbul physical therapy and rehabilitation training and research hospital, sports medicine outpatient clinic and were diagnosed with pfp by a specialist physician based on the patient histories, physical examinations, and diagnostic imaging. the estimated desired sample size was at least 14 participants per group. we anticipated a dropout rate of 20%. therefore, 34 participants were required for each group (supervised rehabilitation n=17, pilates exercises n=17) of both sexes, ages ranging from 18-45 years. a computer generated randomization list was used to divide the patients into two groups (https://www.randomizer.org/). an 'informed consent form' was obtained from patients by explaining the purpose of the study, the duration of the study, the treatments to be applied, and possible side effects.

Eligibility criteria:
inclusion criteria: * having characteristic signs of pfp (retropatellar or peripatellar pain) * presence of at least 3 points of retropatellar or peripatellar pain on the numbered pain rating scale (nprs) with squatting, climbing stairs, prolonged sitting, or functional activity that burdens the pfp * presence of any of the criteria such as tenderness, small effusion in the patellar facet palpation exclusion criteria: * patellofemoral dislocation, subluxation, intra-articular knee pathology * previous lower extremity surgery, and knee-related trauma * a history of hip pathology or neurological disorders * knee trauma in the last 1 month

Keywords: patellofemoral pain core quality of life exercise strength pilates
onset of effect of mometasone nasal spray in induced allergic rhinitis (study p03431)

Conditions: Allergic Rhinitis

Summary: this was a single-dose study to determine the time it takes for mometasone furoate nasal spray to go in effect, after a single dose of 2 sprays per nostril. patients who are eligible were exposed to ragweed pollen for 3 hours on one or two occasions. patients who experienced adequate symptoms during the pollen exposure phase came back for a treatment phase visit. during the treatment phase visit, patients were exposed to ragweed pollen for 2 hours and then received either mometasone or placebo nasal spray. symptom evaluations began on the patients every hour for the next 11 hours.


Eligibility criteria:
inclusion criteria: * at least 12 years old, * had a history of sar to ragweed pollen for at least one year * had a positive skin test (prick) to short ragweed allergen. * if female, had a negative urine pregnancy test (hcg) at the screening visit, and prior to treatment on the treatment visit * were non pregnant women of childbearing potential and used a medically acceptable, adequate form of birth control. exclusion criteria: * developed signs or symptoms of bronchospasm, i.e., wheezing, dyspnea, and/or cough, during the priming sessions; * had any significant medical condition which, in the judgment of the investigator, might interfere with the study or require treatment; * had an upper respiratory or sinus infection within two weeks prior to treatment; * had received escalating doses of immunotherapy, oral immunotherapy or short course (rush) immunotherapy for treatment of rhinitis; * were female subjects who were pregnant, breast feeding, or premenarchal; * could not adhere to concomitant medication prohibitions; * had a known potential for hypersensitivity, allergy, or idiosyncratic reaction to mometasone furoate nasal spray; * had asthma that requires systemic or inhaled corticosteroid treatment; * had large nasal polyps, marked septum deviations, or any other nasal structural abnormality that significantly interferes with nasal airflow; * had rhinitis medicamentosa; * had any relevant abnormal vital sign due to an unknown underlying disease and considered by the investigator and sponsor monitor to contraindicate study participation.
effect of self-acupressure on middle ear barotrauma associated with hyperbaric oxygen therapy

Conditions: Hyperbaric Oxygen Therapy; Middle Ear Barotrauma

Summary: middle ear barotrauma (meb) is the most common complication during hyperbaric oxygen therapy (hbot). though valsalva and toynbee maneuvers have been proposed to prevent meb, still some patients discontinue hbot due to severe otalgia, hemorrhage or perforation of tympanic membrane associated with hbot. currently, there is no optimal prophylactic management for meb associated with hbot. the aim of this protocol is to investigate the efficacy of self-acupressure therapy on meb associated with hbot.


Eligibility criteria:
inclusion criteria: * aged 20 years or order receiving the first hbot * alert consciousness exclusion criteria: * pregnancy * having any acute disorder of the ears or upper respiratory tract * having evidence of neurologic dysfunction precluding them from making an informed decision * having a tracheostomy or endotracheal intubation * having received a myringotomy, tympanoplasty, mastoidectomy or tympanostomy tube placement.

Keywords: hyperbaric oxygen therapy middle ear barotrauma acupressure
four-week open-trial extension tns for adhd

Conditions: Attention Deficit Hyperactivity Disorder (ADHD)

Summary: the purpose of this study will be to offer children previously randomized to sham treatment in a 5-week double-blind sham controlled study of trigeminal nerve stimulation for adhd (nct02155608) an opportunity to receive 4-weeks active tns treatment.

this study will enroll participants with adhd who previously participated in a 5-week sham-controlled investigation of trigeminal nerve stimulation as a treatment for adhd, and who were randomized to the sham condition. in the double-blind trial (nct02155608), children ages 8-12 years undergo study screening and if eligible begin 4 weeks nightly treatment with active or sham tns administered nightly during sleep. at the conclusion of the 4-week trial, all interventions (both active and sham tns) are discontinued with blinding remaining in place for an additional week to assess possible residual treatment effects. participants' randomized condition is unblinded at week 5. all participants randomized to sham in the double-blind trial are invited to participate in a 4-week open-trial of tns to allow all participants the opportunity to benefit from the active intervention. during this 4-week open-extension trial, interested participants will receive nightly active tns during sleep. the final study visit (visit 5) of the double-blind study will serve as baseline for this open-extension. participants will return for clinic assessments at weeks 2 and 4. participants who achieve clinically significant improvement from active tns over the 4-week open trial will be invited to receive a year of nightly active-tns therapy as part of a 12-month extension study.

Eligibility criteria:
inclusion criteria: * male and female children ages 8-12 with dsm-5 adhd, and current presentation, as determined by ksads and clinical interview * participated in a previous randomized, double-blind, sham-controlled trial of tns for adhd, and randomized to the sham condition. * parents able and willing to monitor proper use of the tns device and complete all required rating scales * parent and participants able to compete study rating scales and other measures in english exclusion criteria: * currently requiring any medication with cns effects

Keywords: adhd neuromodulation trigeminal nerve stimulation
effect of metformin in patients with type-1 diabetes with inadequate glycaemic control by insulin and diet

Conditions: Diabetes Mellitus, Type 1

Summary: ninety percent of patients with type-1-diabetes will develop late-diabetic complications in the eyes, kidneys, nervous- or cardiovascular-system. poor glycaemic control is an important risk-factor for development of these late-diabetic complications. the diabetes control and complications trial (dcct)-study showed, that improved glycaemic control can prevent the development and progression of these late-diabetic complications. until now treatment with insulin- and diet-therapy has been the only treatment-modalities available to improve the glycaemic control in patients with type-1-diabetes. a substantial number of these patients still have long-standing poor glycaemic control despite intensive treatment with insulin- and diet-therapy. the antidiabetic drug metformin has shown to be able to improve the glycaemic control in combination with insulin and furthermore reduce both mortality and the risk of developing cardiovascular disease in patients with type-2-diabetes. only few small studies have investigated the effect of treatment with metformin in patients with type-1-diabetes. these studies have suggested a positive effect of metformin in these patients too. method: 100 patients with type-1-diabetes with persistent poor glycaemic control i.e. hba1c \> 8.5% during the last 12 months are eligible. patients are treated for one month with placebo. hereafter half of the patients will be treated with metformin and the other half continues with placebo for 12 months both as add-on therapy. all patients are continuing ongoing treatment with insulin throughout the study. before and after the start of treatment with metformin the effect on glycaemic control and other known risk-factors for development of cardiovascular disease i. e. blood-pressure, fasting lipids, urine-albumine-excretion, endothelial dysfunction, inflammation, fibrinolysis etc. is assessed. this study will show if treatment with metformin can improve the glycaemic control and hereby the prognosis of patients with type-1-diabetes with persistent poor glycaemic control despite intensive treatment with insulin- and diet-therapy. this group of patients suffers the highest risk of developing late-diabetic complications with reduced quality of life and life-expectancy as a consequence.


Eligibility criteria:
inclusion criteria: * hba1c \> 8.5% for more than one year prior to enrolment. * diabetes-duration \> 5 years. * age at onset of diabetes \< 35 years * fasting c-peptide \< 300 pmol/l * age \> 18 years at enrolment. exclusion criteria: * clinical or biochemical signs of kidney-, liver- or heart-failure. * other coexisting serious morbidity, which will affect the study-participation or outcome of the study i.e. cancer. * known abuse of any medication or alcohol * hypoglycaemia unawareness. * pregnancy or planned pregnancy in the study-period.
the effect of education and telephone follow-up intervention based on the roy adaptation model

Conditions: Myocardial Infarction

Summary: in this parallel randomized controlled trial (n = 33/group), the control group received routine care, while the intervention group received a telephone follow-up intervention, which consisted of a pre-discharge education program and three telephone follow-up sessions based on the roy adaptation model.

objective: to evaluate the effect of education and telephone follow-up intervention based on the roy adaptation model (ram) for improving mi patients' self-efficacy, quality of life and lifestyle adaptation. methods: in this parallel randomized controlled trial (n = 33/group), the control group received routine care, while the intervention group received a telephone follow-up intervention, which consisted of a pre-discharge education program and three telephone follow-up sessions based on the ram. data were collected before discharge, and in the 12th week after discharge included quality of life, coping adaptation process, self-efficacy and lifestyle changes.

Eligibility criteria:
inclusion criteria: 1. participants were adults aged ≥30 years and had been admitted to the hospital with a diagnosis of mi (which must be supported by ecg and an increase in biomarkers). 2. were clinically stable 3. willing to participate 4. able to understand and write turkish 5. able to receive telephone calls or fill in questionnaires. 6. able to come to the hospital for checkups. exclusion criteria:patients were excluded from the study if according to medical file records they had chronic renal failure, cancer, heart failure, severe aortic stenosis, if they were planned for surgical treatment or had chronic cognitive and psychiatric disease, if they had problems with hearing and speaking on the phone, or if they had mobility restriction.

Keywords: lifestyle change telephone follow-up roy adaptation model
trigger point dry needling in patient with patellofemoral pain syndrome

Conditions: Patellofemoral Pain Syndrome

Summary: this study intends to determine the effects of trigger point dry needling in patients with patellofemoral pain syndrome.

this is a single blinded randomized controlled trial, will be conducted at district head quarter (dhq) hospital taunsa sharif. dry needling is a technique used to release myofascial trigger points. this study is planned to determine the effects of dry needling on quadriceps muscle in patients with patellofemoral pain syndrome. the sample size was calculated to be n=92 through open epi tool version 3, with 95 % confidence interval (ci), and power 80%, after the completion of therapeutic protocols, the participants will be assessed with the help of numeric pain rating scale (nprs), algometer and anterior knee pain scale along with knee range of motion(rom)

Eligibility criteria:
inclusion criteria: * males and females with age limit 20 to 40 years, * active knee extension/90-90 test positive for screening (with ake range less than 160 degrees), * no known history of hip joint or knee joint disease, * no history of recent hamstring strain. exclusion criteria: * patient with meniscal tears, patellar tendinopathy, and ligamentous injuries. * patient with knee osteoarthritis * patient with lumbosacral nerve root or peripheral nerve involvement

Keywords: anterior knee pain syndrome patellofemoral syndrome