Kornimate/medical-research-clean huggingface dataset:
the role of s-nitrosohemoglobin in regulating systemic blood flow during hypoxia and normoxia

Conditions: Focus is Determination of the Role of SNO-Hb in Forearm Blood Flow Regulation

Summary: nitric oxide is believed to contribute to regulation of blood flow by its selective binding to circulating hemoglobin (forming s-nitrosohemoglobin, sno-hb) and release in a po2-dependent manner. this study is designed to test that hypothesis by measuring the effect of hypoxia and exercise on forearm blood flow before and after depletion of sno-hb using oral n-acetylcysteine.

no has been shown to associate with erythrocytes in the form of sno-hb and can deliver vasomotor changes as erythrocytes pass through a physiologic o2 gradient. the aim of this study is to transiently deplete circulating sno-hb levels to prove that these levels are directly linked with the normal physiological vasodilation that occurs in response to brief hypoxia that occurs in moderate exercise. this study will be performed on healthy volunteers especially with no predisposing cardiovascular or respiratory conditions that may change their vasomotor response to hypoxia. systemic blood flow will be approximated using non-invasive forearm venous occlusion plethysmography which will be performed initial to gather baseline data. the participants will then undergo 4 days of 600 mg bid oral n-acetylcysteine (nac) solution treatment which acts as a bait reactant for no groups bound to hemoglobin (sno-hb) and will then undergo retesting with forearm plethysmography. at the time of both blood flow measurements, arterial blood samples will also be gathered via an arterial catheter inserted on each of two testing days to determine sno-hb levels. statistical analysis will include measuring the blunting of the hypoxia response and sno-hb levels using baseline testing as a self-control for each participant. large scale human placebo-controlled trials with high-dose oral nac (up to 8000 mg/day) for periods up to 12 months have shown no clinically significant adverse reactions, much less than in the proposed study.

Eligibility criteria:
inclusion criteria: * healthy volunteers exclusion criteria: * pregnancy * smoking * pulmonary disease * cardiovascular disease
comparison between bupivacaine and bupivacaine- dexamethasone qlb for postoperative analgesia

Conditions: Post Operative Pain

Summary: the objective of this study is to assess the analgesic sparing effect of adding dexamethasone to bupivacaine in quadratus lumborum block in patients undergoing laparoscopic cholecystectomy under general anesthesia.

background: the qlb is an effective analgesic technique for various abdominal wall incisions. the qlb covers t7 to l2 dermatomes by the spread of la drugs either into the paravertebral space or in the thoracolumbar plane, through iliohypogastric and ilioinguinal nerves, a and c fiber nociceptors, mechanoreceptors and high-density network of lumbar sympathetic fibers. objective: to assess the analgesic sparing effect of adding dexamethasone to bupivacaine in quadratus lumborum block in patients undergoing laparoscopic cholecystectomy under general anesthesia. patients and methods: sixty patients scheduled for elective laparoscopic cholecystectomy surgeries under general anesthesia were included in this study, they were divided into two groups. group a (perineural dexamethasone and bupivacaine group) \[n=30\] those cases will receive 2ml volume of dexamethasone (8mg) combined with 18 ml of bupivacaine of 0.25% concentration. group b (perineural bupivacaine group) \[n=30\] those cases will receive perineural 18 ml bupivacaine (0.25%) combined with 2 ml normal saline.

Eligibility criteria:
inclusion criteria: 1. adult patients aging \> 18 years of both sexes. 2. patients undergoing laparoscopic cholecystectomy surgeries (duration of operation 50-80 minutes). 3. asa physical status classes i - ii. exclusion criteria: 1. patient's refusal of procedure or participation in the study. 2. asa classes iii or above. 3. coagulopathy and bleeding disorders. 4. local skin infections 5. body mass index \>40kg/m2

Keywords: bupivacaine dexamethasone quadratus lumborum block
evaluation of the early use of norepinephrine in major abdominal surgery on postoperative organ dysfunction

Conditions: Norepinephrine; Hypotension; Anesthesiology; Major Abdominal Surgery

Summary: hemodynamic instability is frequent during surgery and intraoperative hypotension is associated with excess morbidity and excess mortality in high-risk patients. in major abdominal surgery the incidence of intraoperative hypotension remains high. for the past few years, some teams have proposed evaluating norepinephrine as a first-line drug in the presence of hypotension or even before hypotension occurs thus in obstetrics, the preventive use of norepinephrine for cesareans performed under spinal anesthesia was associated with a reduction in the incidence of hypotension per operative without deleterious effect for the newborn or parturient. in the absence of any observed complications, several teams began to use noradrenaline prophylactically in other surgery. however, no study has demonstrated its benefit, particularly the term of surgical complication in abdominal surgery. the objective of this work is to assess the preventive use of norepinephrine in major abdominal surgery on the occurrence of intraoperative hypotension, postoperative organ dysfunction and postoperative medical and surgical complications.


Eligibility criteria:
inclusion criteria: * patients scheduled for major abdominal surgery (defined as surgery with a risk of cardiovascular complications of \>1% and/or lasting more than 2 hours) with general anaesthesia. * american society of anesthesiologists physical status (asa-ps) score of ≥2. * age of ≥50 years and weighing more than 50 kg * written informed consent. exclusion criteria: * emergency surgery. * untreated or uncontrolled hypertension (systolic blood pressure of \>150 mm hg), despite medication. * any acute cardiovascular event, including acute or decompensated heart failure or acute coronary syndrome. * patients with chronic kidney disease with a glomerular filtration rate of \<30 ml.min-1/1.73 m2 or requiring renal replacement therapy for end-stage renal disease. * patients with severe hepatic failure (asat/alat of \>2n, elevated bilirubin level, pt of \<50%). * preoperative sepsis, septic shock. * preoperative norepinephrine infusion. * patients eligible for a surgical procedure under locoregional anaesthesia. * pregnancy. * known allergy to study treatment. * patients unable to give informed consent for any reason.

Keywords: norepinephrine ephedrine hypotension anesthesiology major abdominal surgery clavien dindo score
usefulness of a mobile information management system for haemodialysis patient

Conditions: Quality of Life; Drug Habit

Summary: the investigators developed and used the dialysisnet mobile application for physicians and avatar beans mobile application for haemodialysis patients. patient-centred data integration and exchange were based on the american society for testing and materials continuity of care record standard. the investigators enrolled 10 patients and 4 physicians. questionnaires to evaluate user experience and usefulness were administered before and after use.


Eligibility criteria:
inclusion criteria: * patients who have maintenance hemodialysis treatment * accept consent form exclusion criteria: * pregnant
wise interventions and responses to stress

Conditions: Stress, Physiological; Stress, Psychological; Social Stress; Depression

Summary: this study compares the effects of two wise interventions (implicit theory of personality intervention and implicit theory of personality intervention plus self-affirmation) with a control condition in the stress responses of young adults. responses include respiratory sinus arrhythmia, heart rate, skin conductance level, cortisol levels, and mood.

whereas several studies indicate that implicit theory of personality interventions (itp) are promising in the prevention of depressive symptoms, evidence about the effects of the itp intervention on stress pathways is scarce. the current study aims to elucidate the effects of itp on psychophysiological responses to social stress in young adults during their transition to university. based on preliminary findings that itp was more effective among younger adolescents in reducing depressive symptoms and that a combination of itp with self-affirmation (sa) was more effective in the prevention of other risky behaviors, the current study proposes that the addition of a sa component could increase the effectiveness of the itp intervention when responding to stress. thus, this study compares the effects of the itp alone and in combination with a sa component in psychophysiological responses to a standardized social stressor (the trier social stress test, tsst). both interventions (i.e., itp+sa and itp) are compared with a control condition (cc) in indicators of the autonomic nervous system (heart rate -hr-, respiratory sinus arrhythmia -rsa-, skin conductance level -scl-), the hypothalamic-pituitary-adrenal axis (cortisol level), and subjective mood. the investigators expect that participants in both itp interventions, and in itp+sa intervention in particular, will display better stress responses during the stressful tasks compared with participants in the cc (i.e., lower hr and scl increase, lower rsa suppression, and lower cortisol and negative mood increase). the investigators also expect that participants would display better recovery after the stressful tasks (i.e., higher hr and scl decrease, and higher rsa increase). finally, this research will examine whether depressive symptoms moderate the effects of the intervention on stress responses. previous research has shown that depression has been associated with dysregulated stress responses both at the autonomic nervous system and hypothalamic-pituitary-adrenal axis. moreover, some studies have found that interventions are more effective among participants at risk to reduce both depression and stress. therefore, the itp intervention, alone and in combination with sa, could be more beneficial among those participants with higher levels of depressive symptoms.

Eligibility criteria:
inclusion criteria: * informed consent by the participants. * to be fluent in spanish. exclusion criteria: * having cardiovascular disease.

Keywords: trier social stress test social stress stress reactivity heart rate respiratory sinus arrhythmia skin conductance level cortisol mood young adults
incidence, risk factors and outcomes of diaphragm dysfunction after lung transplantation

Conditions: Diaphragm Injury; Lung Transplant; Complications, Mechanical; Respiratory Failure; Mechanical Ventilation Complication

Summary: the study is designed to characterize the changes in diaphragm function after lung transplantation.

diaphragm dysfunction (dd) is a well-known complication after lung transplantation. patients with an injured and dysfunctional diaphragm have greater difficulty weaning from mechanical ventilation post-transplant - they become too weak to breathe. however, little is known about the pre-transplant predictive factors associated with diaphragm dysfunction . we have developed a new technique employing beside ultrasound to measure diaphragm thickness. this allows us to observe changes in diaphragm muscle structure and function. the goal of the study is to determine whether pre-transplant diaphragm thickness and function are associated with diaphragmatic dysfunction after lung transplantation. this will help us to confirm the best way to avoid diaphragm injury and to understanding the meaning of diaphragm ultrasound images.

Eligibility criteria:
inclusion criteria: * adult patients greater than 18 years of age * listed for lung transplantation exclusion criteria: * known diagnosis of chronic neuromuscular disease * relisting for transplantation * bridging to lung transplantation with respiratory support
cortical stimulation by direct current for the treatment of chronic pain : pilot-study of a stimulation device at home

Conditions: Neuropathic Pain

Summary: the purpose of this study is to confirm the analgesic effect of tdcs in neuropathic chronic pain, to estimate the importance and the duration of this effect, and to improve its efficiency by the use at home. it is established that the repetition of the sessions of cortical stimulation over a week improves their analgesic efficacy. however, this effect does not exceed a few weeks and is much lower than that of the stimulation implanted surgically. implanted stimulation operates periodically, several times a day, and this "repetition of doses ", akin to the regular taking of a medicine, may explain its longer efficacy for pain relief which, may extend over several years (andré-obadia and al 2014). no study at this date has estimated the long-term effect of non-invasive stimulation when is also periodically repeated on a daily basis, over several weeks.


Eligibility criteria:
inclusion criteria : * patients from 18 to 80 years old, men or women, suffering pharmaco-resistant neuropathic chronic pain for more than one year; nvs \> 2 during the week s0) unilateral pharmacoresistant, whose analgesic treatment is stable for at least 1 month. * patients whose pharmacoresistance leads their referent doctor to consider non-pharmacological therapeutic alternatives and begin a presurgical assessment. * patients having an operational internet connection. the patient or one person of its circle of acquaintances will have to be able to connect on the internet and to reach by this way the system of relocated stimulation ("the cloud"). * patients having shown pain relief to a single- or whole-week sessions of tdcs are not excluded from potential recruitment for this study. * patients having a social security cover. * patients having given their written consent. exclusion criteria : * history * of addiction to drugs, * of epilepsy. * présence of an intra-cranial ferromagnetic equipment or of an implanted stimulation device (e.g. stimulating, central grey pacemaker, stimulation of the basal ganglia or of the vagus nerve). * introduction of a new analgesic treatment for less than a month. * lack of a effective contraception for all the duration of the study for the patients old enough to procreate. (no limitation in the inclusion of male patients old enough to procreate). * patient under legal protective measure. * pregnant women and nursing mothers

Keywords: neuropathic pain neurostimulation ambulatory use tdcs
evaluation of trichoscopy in the diagnosis of tinea capitis

Conditions: Tinea Capitis

Summary: waiting for a proof by mycological culture is usually necessary before starting a systemic antifungal therapy. it therefore seems to us interesting to evaluate the benefit of using dermoscopy in clinical diagnosis of tinea capitis.


Eligibility criteria:
inclusion criteria: * all patients with clinically diagnosed tinea capitis * patient has signed informed consent exclusion criteria: * patient with kerion or tinea favosa * antifungal treatment within 15 days prior to inclusion
gastrointestinal tolerance of d-allulose in children

Conditions: Healthy

Summary: d-allulose, a low-calorie sugar, provides an attractive alternative to sucrose and added sugars in products. this study aimed to verify the tolerance of d-allulose in children, in doses that are generally recognised as safe (gras) and below maximum tolerable levels on g/kg basis.


Eligibility criteria:
inclusion criteria: 1. healthy children of 6 to 8 years of age 2. weight-for-age between the 5th and the 90th percentile as per the centre for disease control and prevention growth charts 3. accustomed to having lunch between 12.00 pm and 2.30 pm 4. routinely had up to 3 bowel movements per day or as few as 3 bowel movements per week 5. were able to drink 120 ml within 30 minutes 6. with parents willing to continue their child's normal food and beverage intake and physical activity throughout the duration of the study 7. with parents willing and able to attend for all 7 visits exclusion criteria: 1. any major trauma or surgical event within the 3 months prior to screening 2. history or presence of clinically significant endocrine or gi disorder 3. functional gi disorders in accordance with rome iii diagnostic questionnaire for paediatric functional gi disorders 4. more than 1 loose stool in the 48 hours preceding dosing, that met a type 6 or type 7 description on the bristol stool chart 5. use of any prescription medication, including antibiotics, laxatives and steroids 6. regular gi complaints, such as stomach upsets, diarrhoea, constipation, flatulence, abdominal colic 7. known intolerance or sensitivity to any of the study products, abdominal or anorectal surgery 8. psychiatric disorders, anxiety, and depression 9. lactose intolerance 10. use of supplements that may have affected gi system including laxatives, fibre, and iron supplements 11. exposure to any non-registered drug product within 30 days prior to screening visit.
effect of dm on outcomes and response rate in patients with advanced nsclc on ici

Conditions: Non Small Cell Lung Cancer Metastatic; Diabetes Mellitus

Summary: retrospectively investigating the effect of dm on response rate and outcomes during immunotherapy treatment in patients with nsclc in the last 5 years.

lung cancer continues to be the most common cause of cancer-related death worldwide for both males and females despite the identification of clinically-actionable driver mutations in genomic subgroups of patients. non-small cell lung cancer (nsclc) is the most common histological diagnosis for 85% of lung cancer patients. immune checkpoint inhibitors (ici) has significantly altered the prognosis for patients with advanced non-small cell lung cancer (mnsclc) as it has been shown to have distinct and long-lasting impacts on survival in first and second line treatment. as a result, immunotherapy has emerged as the backbone of care for people with nsclc. although some patients benefit considerably from ici, not all patients do. a comprehensive research effort exists to identify and characterize variables that could predict or boost the response to ici. at the same time, diabetes mellitus (dm) is becoming more prevalent globally and lung cancer patients frequently suffer from a variety of comorbidities, including (dm). however, its effect on treatment outcomes is still unclear, particularly in the era of immunotherapy.

Eligibility criteria:
inclusion criteria: * all consecutive patients with advanced non small cell lung cancer who received immune check inhibitors alone or in combination with chemotherapy, either as first line or as a subsequent line exclusion criteria: * none

Keywords: nsclc dm ici oha
evaluation of healing following open gluteus medius repair with biointegrative implant

Conditions: Hip Injuries; Tendon Injuries; Orthopedic Procedures

Summary: this is a prospective, single-center study design with enrollment of 15 subjects. the 15 subjects will all undergo standard gluteus medius repair that includes augmentation with the biointegrative implant. this is a small observational study. as such, we expect that the results from 15 subjects will give an adequate understanding of post surgical healing.

surgical gluteal tendon repair is a procedure performed regularly in operating rooms everywhere. this procedure is normally recommended to address gluteal tendon tears after nonoperative treatment options have been exhausted. however, less than satisfactory long-term outcomes can be common after open gluteal tendon repair. the augmentation of tendon repairs via various biointegrative implants is becoming more common in clinical practice, however very little, if any, of the literature details the healing after surgical intervention. biointegrative implants have been studied for the use of augmenting other tendon repairs, such as rotator cuff tears. successful complete rotator cuff repairs augmented with a collagen-based implant have indicated that biointegrative implants are a safe option that may provide greater rates of healing and more positive long-term outcomes (thon sg, 2019). rates of healing and long-term outcomes when using a patch of this sort in other tendons such as the gluteal tendon in the hip show promise and demonstrate that there is a need for this area of study. a 2016 study evaluated augmenting gluteus medius repair with a bioinductive implant, but the surgery was performed using endoscopic technique. there is no literature studying the healing of collagen-based implants for open gluteal tendon repairs. although clinical outcomes show similar level of improvement for endoscopic and open gluteal tendon tear repair (maslaris a, 2020), open repair technique with more anchors may be required for larger or more intricate tears. this is a prospective, single-center study design with enrollment of 15 subjects. the 15 subjects will all undergo standard gluteus medius repair that includes augmentation with the biointegrative implant. this is a small observational study. as such, we expect that the results from 15 subjects will give an adequate understanding of post surgical healing.

Eligibility criteria:
inclusion criteria: 1. patients at least 18 years of age 2. patients healthy enough to undergo procedure 3. large partial tear and full thickness gluteal tendon tear requiring augmentation 4. willing and able to make all required visits 5. able to read and write in english exclusion criteria: 1. hypersensitivity or objection to using bovine derived materials 2. significant atrophy or major retraction of gluteal tendon 3. women who are pregnant or nursing 4. history of poor compliance with medical treatment 5. patients who are incarcerated