blood flow restriction training in rehabilitation patients

Conditions: Anterior Cruciate Ligament Reconstruction; Volumetric Muscle Loss; Chronic Thigh Muscle Weakness; Knee Arthroscopy

Summary: occlusion training, resistance exercise performed with a specialized venous tourniquet, leads to beneficial changes in muscle at low resistance and minimal stress on the nearby joint. this novel resistance training has the potential to greatly improve extremity muscle strength gains for rehabilitation patients who are unable for medical reasons to perform high resistance exercise. our study will explore this with specific rehabilitation populations: post-operative knee scopes, post-operative anterior cruciate ligament (acl) reconstruction patients who have acute post-operative changes in thigh muscle function and chronic thigh weakness. the primary outcome is to achieve accelerated functional thigh recovery with outcome measures including thigh strength, validated questionnaires, and validated functional testing. occlusion training can enhance rehab patients outcomes, reduce the cost of care, and improve the skills and efficiency of care providers.

occlusion training is the restriction of venous outflow from an extremity with the use of a tourniquet during weight-training or resistance exercises. the technique is a safe and effective method of improving strength through muscle hypertrophy in healthy, active individuals (1-7). the technique has also been shown to be safe and effective in patient populations with various comorbidities (8).these strength gains can be achieved while training with loads as low as 20% of an individual's one repetition maximum (1rm). this is contrary to the american college of sports medicine (acsm) weight-training guidelines that state muscle hypertrophy can only be achieved when an individual lifts loads close to 80% of the 1rm (9). the purpose of this project is to compare occlusion resistance training to traditional resistance training methods for rehabilitation patients. this will include both an acute post-operative acl reconstruction cohort and a chronic thigh weakness cohort. post-operative lower extremity weakness as well as chronic muscle weakness after trauma correlate with lower functional performance.(10,11) we will treat the patients and follow these two cohorts simultaneously. specific aim 1: to determine if occlusion training will accelerate the recovery of thigh muscle function and strength in post-operative anterior cruciate ligament (acl) reconstruction as compared to a standard post-operative rehabilitation protocol. specific aim 2: to determine if occlusion training will increase quadricep and hamstring muscle function for battlefield wounded warriors with severe thigh weakness as a result of trauma or volumetric muscle loss as compared to standard acsm resistance training guidelines. specific aim 3: to determine if occlusion training will accelerate the recovery of thigh muscle function and strength in post-operative soft tissue knee arthroscopy as compared to a standard post-operative rehabilitation protocol.

Eligibility criteria:
inclusion criteria: * one of the following: (1) s/p acl reconstruction within the last three months prior to initiation of study training, (2) s/p knee arthroscopy within the last 2 weeks prior to initiation of study training, (3) s/p lower extremity trauma, unilateral with thigh weakness of at lest a 20% deficit compared to contralateral side and at least 6 months out from most recent trauma or surgery * fluent in english and able to consent exclusion criteria: * contralateral lower extremity involvement resulting in less than normal range of motion, muscle strength, or daily pain greater than 5/10. * pregnancy, verbal reporting * recent history of deep vein thrombosis, within the 12 months or on active treatment * history of endothelial dysfunction, peripheral vascular disease, hypertension, diabetes, or people prone to capillary ruptures (bruising) (determined by verbal reporting by the patient) * active infection * cancer (current diagnosis)