Kornimate/medical-research-clean huggingface dataset:
active commuting to improve well-being and health in everyday life

Conditions: Overweight and Obesity

Summary: the aim of present randomized controlled trial is to evaluate the health effects of physical activity in transport and leisure time domains of everyday life and to develop durable physical activity regimens, i.e. to go from lifestyle intervention to daily lifestyle routine, in overweight individuals. subjects will be randomized to 1 of 4 groups. 1: vigorous intensity leisure time physical activity, 2: moderate intensity leisure time activity, 3: active commuting by bicycle, or 4: a non-intervention control group


Eligibility criteria:
inclusion criteria: * healthy * no engagement in habitual structured physical activity * body mass index 25-35 kg/m2 * body fat percentage \>32% for women and \>25% for men * maximum oxygen uptake (vo2max) \<40 ml o2/kg/min for women and \<45 ml o2/kg/min for men * ethnicity: caucasian exclusion criteria: * chronic use of medicine * smoking * fasting plasma glucose \> 6,1 mmol/l * blood pressure \> 140/90 mm hg * abnormal resting and working ecg * parents or siblings with diagnosed type 2 diabetes * for women: follicle stimulating hormone (fsh) concentration \> 35 milliunits/ml, pregnancy or planning of pregnancy within the coming year
very low nicotine cigarettes in smokers with schizophrenia

Conditions: Tobacco Dependence

Summary: smokers with serious mental illness including those with schizophrenia and bipolar disorder infrequently attempt and attain sustained smoking abstinence and have a 25-year shorter lifespan due to smoking-related illness. this study will examine whether reducing the nicotine content of cigarettes to non-addicting levels is a viable method of reducing smoking in smokers with serious mental illness. smokers will be randomized to one of two experimental conditions: 1) very low nicotine content (vlnc) cigarettes or 2) normal nicotine content (nnc) cigarettes. participants will be assessed for patterns of tobacco use, biomarkers of exposure, subjective responses (e.g., satisfaction, craving, withdrawal symptoms), psychiatric symptoms, cognitive performance, smoking cue reactivity and smoking topography.


Eligibility criteria:
inclusion criteria: * age 18-70 * schizophrenia, schizoaffective disorder or bipolar disorder * smoke an average of at least 10 cigarettes per day for at least 1 year * breath carbon monoxide (co) levels \>8 ppm (if ≤ 8 ppm, then nicotine (nicalert) strip \> 2) exclusion criteria: * pregnant or nursing * seeking treatment for smoking * medical contraindications
gasdermin d expression in generalized vitiligo patients after narrow-band ultraviolet b therapy

Conditions: Vitiligo, Generalized

Summary: the aim of this study is to: 1. evaluate the role of tissue gasdermin d expression using immunehistochemstry techniques in patients with generalized vitiligo and compare it with healthy controls. 2. evaluation expression of tissue gasdermin d using immunehistochemstry techniques in patients with generalized vitiligo after narrow band ultraviolet b therapy. 3. determine whether there is a relationship between gasdermin d levels and disease duration and involved body surface area (visa) in vitiligo patients.

the aim of this study is to: 1. evaluate the role of tissue gasdermin d expression using immunehistochemstry techniques in patients with generalized vitiligo and compare it with healthy controls. 2. evaluation expression of tissue gasdermin d using immunehistochemstry techniques in patients with generalized vitiligo after narrow band ultraviolet b therapy. 3. determine whether there is a relationship between gasdermin d levels and disease duration and involved body surface area (visa) in vitiligo patients.

Eligibility criteria:
inclusion criteria: * patients with stable vitiligo of 6 months duration, * both sex and ages(10-75) exclusion criteria: * pregnancy, * lactation, * patients under or previous phototherapy, * patients on other immunosuppressives, * patients receiving topical or systemic therapy like antioxidants and vitamins were kept off treatment for 2 weeks prior to recruitment into the study.
intermediate-term outcomes of laparoscopic pectopexy and vaginal sacrospinous fixation: a comparative study

Conditions: Laparoscopic Pectopexy and Vaginal Sacrospinous Fixation

Summary: forty-three women who had vaginal sacrospinous fixations using dr. aksakal's desta suture carrier and 36 women who had laparoscopic pectopexies between january 2014 and june 2018 at h.s.u kocaeli derince training and research hospital gynecology and obstetrics clinic were re-examined between 15 june and 30 december 2018 gynecologically.

forty-three women who had vaginal sacrospinous fixations using dr. aksakal's desta suture carrier and 36 women who had laparoscopic pectocolpopexies were re-examined 7 to 43 months after surgery. all of the women had undergone surgery for stage 2 or greater uterovaginal or vaginal vault prolapse according to the pelvic organ prolapse quantification (pop-q) system. all of the patients received telephone calls and were invited for a gynecological re-examination. all but one patient in the vaginal surgery group came in for a gynecological control. we conducted a phone interview with the one patient not agreeing to come to the control, and we learned that she had a relapse 6 months after the operation. she underwent another prolapse surgery at a different hospital. she described her postsurgical complaints, and we noted that she was unsatisfied with the surgery. in the postoperative re-evaluation between 15 june and 30 december 2018, all of the women were examined in the lithotomy position for apical, anterior, and posterior compartment descensus. stage 2 or greater apical descensus or a cystocele or rectocele according to the pop-q system were accepted as postoperative relapses. all of the patients answered the pelvic organ prolapse/urinary incontinence sexual questionnaire (pisq-12) and prolapse quality of life (p-qol) questionnaire. all of the women were asked about de novo urge urinary incontinence and de novo stress urinary incontinence. in addition, each patient's satisfaction with the surgery was asked and recorded.

Eligibility criteria:
inclusion criteria: those patients with stage 2 or greater uterovaginal/vaginal cuff prolapses according to the pop-q system underwented to surgery (vaginally or laparoscopically) between january 2014 and june 2018 were included to the study. exclusion criteria: women who had surgeries for malignancy suspicion or pelvic inflammatory disease and women with pectouteropexy procedure were not included into the study.

Keywords: outcomes pectopexy sacrospinous ligament fixation prolapse surgery
cpap in-home assessment usa

Conditions: Obstructive Sleep Apnea

Summary: the study is to evaluate the product reliability, therapy effectiveness and user feedback of a continuous positive airway pressure (cpap) device in-home for up to 6 months.

existing and naïve cpap users will be recruited into a 6 month in-home study participants will attend 5 study visits at day 0, 7, 30, 60 and 180. outcome of the clinical investigation include downloadable device data reports, device error reports and participants perception questionnaires.

Eligibility criteria:
inclusion criteria: * aged 22 and over * diagnosed with obstructive sleep apnea (osa) and prescribed positive airway pressure (either continuous positive airway pressure (cpap) or autocpap) * for experienced users of pap (cpap or autocpap) - you must be using pap of more than 4 hours/night for 70% during the last 30 days. exclusion criteria: * contraindicated for pap (cpap or autocpap) therapy * has other significant sleep disorders (e.g periodic leg movements, insomnia, central sleep apnea) * has obesity hypoventilation syndrome or congestive heart failure * requires supplemental oxygen with their pap (cpap or autocpap) device * has implanted electronic medical devices (e.g cardiac pacemakers) * pregnant or think they may be pregnant * not fluent in spoken and written english.
investigation of the effect of "curtain" use on self-injection, testing fear and pain in patients with type 2 diabetes

Conditions: Type 2 Diabetes Mellitus 2; Insulin Dependent Diabetes Mellitus

Summary: diabetes is a global problem for the world and negatively affects life (1). the most important reasons for ineffective diabetes and insulin treatment include fear of insulin side effects, fear of insulin injection, social embarrassment from administering insulin, fear of hypoglycemia and/or hyperglycemia (2). a large portion of diabetic individuals experience these fears, and some of these patients cope with these fears and integrate them into their daily lifestyles. however, some diabetic patients may be ineffective in coping with these fears (3). this situation creates negativities in the individual's success in treatment and compliance with treatment (3). diverting attention is one of the non-pharmacological methods used in pain control. diverting attention is one of the most preferred methods in reducing the pain experienced by patients during diagnosis and treatment procedures. it is a method that allows patients to control and reduce their symptoms by focusing their attention on a different point (4). in this study, the use of a distracting curtain during self-injection in individuals with type 2 diabetes will be examined in order to examine the effect of pain and fear.

research type: it is designed as a randomized controlled, regular research. research universe and samples: the research groups will be the living diabetes cells of dicle university hospitals. the research aims to create 100 healthy diabetes patients in dicle university hospital.

Eligibility criteria:
inclusion criteria: * type 2 diabetes for at least one year * self-administering insulin injections * self-administering a glucometer, insulin pen or insulin pump, exclusion criteria: * poor mental health * having gestational diabetes mellitus or type 1 diabetes

Keywords: type 2 diabetes mellitus, insulin, fear, pain, curtain self-injection
shockwave treatment for advanced angina in maastricht

Conditions: Angina

Summary: there is an increasing number of patients with a coronary anatomy that does not allow additional revascularization procedures, while the patients suffer from angina pectoris at rest or at minimal exercise levels despite optimised medical therapy. there is a lack of therapeutic options for this group of so called "no-option patients". goal of the project is to implement the shockwave therapy for no-option coronary artery disease patients and to evaluate its potential benefit on regional myocardial perfusion, on regional myocardial function and on the potential improvement in symptoms and quality of life.


Eligibility criteria:
inclusion criteria: * chronic angina pectoris ccs (canadian cardiological society) iii or iv with documented reversible ischemia and/or hibernation. * patients demonstrates exercise tolerance test (ett) duration \< 10 minutes on a modified bruce protocol * no possibility of traditional revascularization by coronary artery bypass grafting (cabg) or percutaneous coronary intervention (pci) * patient's conditions stable for at least 3 months * life expectancy of \> 12 months. exclusion criteria: * unstable angina pectoris * haemodynamically significant valvular heart disease * myocardial infarction \<3 month prior randomization * evidence of intracardiac thrombus * contraindication for magnetic resonance imaging (mri) (pacemaker, metallic prostheses) * patient is simultaneously participating in another device or drug study, or has participated in any clinical trial involving an experimental device or drug, including other drugs or devices enhancing cardiac neovascularization or any extracorporeal shock wave therapy (eswt) machine for neovascularization of a competitor company within 3 months of entry into the study. * patients who are unwilling or unable to cooperate with the study procedure. * age \< 18 years * cardiac or pulmonary malignancy * no informed consent * known depression

Keywords: anginal complaints lithotripsy no option patients
lung ultrasound score (lus) change in robotic and laparoscopic urologic surgeries

Conditions: Atelectasis

Summary: robotic and laparoscopic surgeries are tend to cause lung atelectasis due to the insufflation of co2 into abdomen. however, ultrasonographic measurement for this phenomenon and its clinical use is not well investigated. in this particular study, it is aimed to observe lung ultrasound score (lus) changes in robotic and laparoscopic supine position surgeries such as prostatectomies and cystectomies. lus is a pragmatic measurement method that calculates the degree of atelectasis and consolidation in the lungs. both hemithoraxes are separated into 3 different segments with vertical lines (one between the parasternal line and anterior axillary line, one between the anterior and posterior axillary line, and one posterior to the posterior axillary line). these vertical segments are also divided into two with an horizontal line on the nipple. lung ultrasonography is applied in all 12 zones for both lungs in the intercostal regions and a scoring system is used. accordingly, pure a lines (transverse frequent lines) reflects normal lung tissue with no consolidation and scored as zero points (also named "a"). if less than 4 b lines (vertical lines reflecting some degree of consolidation) is observed, it refers to 1 point (named "b1"). 4 or more b lines refers to 2 points (b2), and if wide and coalesced b lines or patchy pleural line is observed that refers to 3 points (c). all evaluations will be made in supine position. in this trial, lus will be applied in three different time points: t1: 5 minutes after orotracheal intubation t2: at the end of surgery, before extubation (under deep anesthetic state) t3: 30 minutes after extubation, in postanesthesia care unit during the surgery and the postoperative care period standart monitorization and mechanical ventilation data will be gathered. also intraoperative and postoperative blood gas analysis will be obtained to observe oxygenation changes. this study is planned as a prospective observational study and our hypothesis is that lus scores would be lower in acute postoperative period with robotic and laparoscopic surgeries. therefore primary outcome is the numeric change in t3 and t1. secondarily, lus scores will be evaluated between robotic group and laparoscopic group patients for all time points.


Eligibility criteria:
inclusion criteria: * \>18 years * laparoscopic urologic surgeries * robotic urologic surgeries * surgeries under supine and trendelenburg position exclusion criteria: * known lung disease * emergency surgeries * known cardiac failure * known pulmonary hypertension * patients receiving inhaled agents * patients requiring lateral position surgeries
ablative carbon ion radiotherapy with pencil beam scanning for locally advanced unresectable pancreatic cancer

Conditions: Pancreatic Cancer Non-resectable

Summary: the aim of this study is to investigate the clinical efficacy and safety of ablative carbon ion radiotherapy for locally advanced unresectable pancreatic cancer with pencil beam scanning and simultaneous integrated boost (sib) technology.

the aim of this study is to investigate the clinical efficacy and safety of ablative carbon ion radiotherapy for locally advanced unresectable pancreatic cancer using pencil beam scanning and simultaneous integrated boost technology with respect to toxicity and tumor control. all enrolled patients will receive carbon ion radiotherapy for the primary pancreatic lesions, positive lymph nodes, and retroperitoneal high-risk recurrence areas. the prescription dose for primary pancreatic lesion, positive lymph node, and retroperitoneal high-risk recurrence area is 67.5 gy (rbe weighted dose) in 15 fractions for 3 weeks; pancreatic primary lesion and positive lymph node sib to 75 gy (rbe weighted dose) in 15 fractions for 3 weeks. the primary endpoint is 2-year cumulative local regional progression rate (lrp), and the secondary endpoint is to assess the overall survival (os) and toxicities. toxicity was assessed using the common adverse event evaluation criteria (ctcae) version 5.0, and safety and toxicity will be assessed by clinical examination, laboratory examination, and imaging (including ct, mri, and/or pet/ct).

Eligibility criteria:
inclusion criteria: 1. have the ability to sign the written informed consent; 2. ductal adenocarcinoma of the pancreas confirmed by histopathology or cytopathology; 3. distant metastasis was excluded by imaging assessment (pet-ct, cranial mri), and was defined as locally advanced unresectable according to nccn guidelines version 2022.1, that is, t4n0-2m0, stage iii (ajcc/uicc version 8); 4. the maximum diameter of pancreatic primary lesion and positive lymph node ≤7cm; 5. pancreas primary lesion or positive lymph node did not invade digestive tract (stomach, duodenum and small intestine); 6. eastern cooperative oncology group (ecog) performance score 0-1; 7. adequate bone marrow function (neutrophil count ≥1.5×109/l, platelet count ≥100×109/l, hemoglobin ≥10.0g/dl); 8. adequate liver function (total bilirubin \<1.5 times the upper limit of normal value, aminotransferase \<2.5 times the upper limit of normal value); 9. adequate renal function (serum creatinine \ 50ml/min). exclusion criteria: 1. multiple primary pancreatic lesions (\>1); 2. tumor invaded the adjacent digestive tract; 3. radiation therapy history; 4. other local treatments history for pancreatic cancer, such as hifu and irreversible electroporation; 5. the irradiation dose of organs at risk cannot reach the dose constraint; 6. other malignant tumors history; 7. inability to understand the purpose of treatment or unwillingness/inability to sign informed consent.

Keywords: locally advanced unresectable pancreatic cancer carbon ion radiotherapy phase ii clinical trial ablative dose optimized linear energy transfer
relief of lumbar spinal stenosis symptoms

Conditions: Spinal Stenosis Lumbar; Low Back Pain

Summary: the aim of this study was to compare the efficacy of caudal epidural steroid injection and caudal epidural pulsed radiofrequency stimulation in the relief of symptoms of lumbar spinal stenosis. this evaluation used the numerical rating scale (nrs) to assess pain relief and the medication quantification scale iii (mqs iii) to assess the effectiveness of the interventions on medication consumption. the rates of adverse events related to the interventions were also compared.

low back pain (lbp) is one of the leading causes of disability worldwide. lumbar spinal stenosis is one of the three most common diagnoses of lower back and leg pain, along with intervertebral disc herniation and degenerative spondylolisthesis. numerous treatment modalities have been proposed for the management of lumbar spinal stenosis, including drug therapy and complex surgical fusion. epidural injections are a nonsurgical intervention commonly used in the treatment of spinal stenosis. saline, local anesthetics, steroids, hylaze, platelet-rich plasma, and pulsed radiofrequency (prf) administered to the caudal epidural space have been reported to be effective in the treatment of pain. among these, caudal epidural prf has been applied in a limited number of chronic painful conditions (failed back surgery syndrome, chronic distal symmetrical polyneuropathy, postherpetic neuralgia, and coccygodynia), and no randomized controlled studies have been conducted. prf produces a nonthermal effect that modulates the transmission of pain signals by delivering a short-term high-voltage electric current to the target nerve. rft provides a continuous current that heats the target tissue and causes coagulation necrosis in nerves. the primary aim of this study was to compare the efficacy of caudal epidural rft and caudal epidural steroid injections in patients with lumbar spinal stenosis. the secondary aim was to determine the effects of the interventions on drug consumption and interventional safety, based on adverse events. a total of at least 50 patients will be enrolled for comparison, with 25 in each group. nrs and mqs iii scores will be compared both within and between groups before and 1, 2, and 3 months after treatment.

Eligibility criteria:
inclusion criteria: among the patients with lumbar spinal stenosis findings and narrowing of the spinal canal detected by examination and imaging methods, those whose back and leg pain persists for at least 3 months exclusion criteria: previous lumbar surgery, pregnancy, history of ongoing malignant disease, autoimmune diseases, active infection of the injection site, hematologic disorders, antiplatelet drug use

Keywords: pulsed radiofrequency treatment lomber spinal stenosis caudal epidural steroid injection
efficacy of prf and mta as compared to calcium hydroxide for pulpotomy in human irreversibly inflamed permanent teeth

Conditions: Pulpitis - Irreversible; Tooth Decay

Summary: of all the various pulpotomy medicaments that have been studied till to date, three agents have been selected for this study to compare their efficacy. ch being the control, mta being one of the most recommended biomaterial and prf that in addition to being a biomaterial is an autologous agent. uptil now there have been no prospective trials using these three pulpotomy agents in mature permanent teeth with irreversible pulpitis in our part of the world and even the international studies that have been done utilized different methodologies with no unanimous conclusion. this is the reason that at present this treatment regime (pulpotomy) showing better perspectives cannot be presented with confidence as a predictable treatment option to the patients with irreversible pulpitis. by virtue of this study this challenge is being undertaken. hypothesis: alternate hypothesis there is a difference between the efficacy of the prf, mta and ch when used as pulpotomy medicaments in mature permanent teeth with irreversible pulpitis null hpothesis there is no difference in efficacy of the prf, mta and ch when used as pulpotomy medicaments in mature permanent teeth with irreversible pulpitis


Eligibility criteria:
inclusion criteria: * patients with permanent teeth with completely formed roots diagnosed with irreversible pulpitis i.e. showing signs and symptoms as spontaneous, lingering pain initiated by hot and cold stimulus and /or radiating. pulp being exposed or near to exposure by caries or alternatively by trauma. exclusion criteria: * clinically teeth with * necrotic pulp * history of swelling, abscess , fistula and/ or sinus tract * doubtful restorability as indicated by over all dental practicality index- (dpi) \> 2 (dawood and patel 2017) will be excluded * periodontal disease * uncontrolled bleeding (more that 10 mins.) of pulp after removal of inflamed part. * no bleeding of pulp at all after access into pulp radiographically (with the use of periapical radiographs) teeth with * internal/ external pathologic root resorption * pulp canal obliteration * periapical / furcal radiolucency * resorbed roots. * crestal bone loss generally patients * with systemic diseases, bleeding disorders, physical or mental disability, pregnant or nursing. * on opioid or steroid therapy or anticoagulants and/or on any kind of antibiotics. * who have gone through some previous treatment for the same tooth other than filling.

Keywords: mta calcium hydroxide prf pulpotomy irreversible pulpitis permanent teeth medicament