Kornimate/medical-research-clean huggingface dataset:
impact of perceptive, executive and emotional factors on decision-making of pedestrian face to autonomous vehicles.

Conditions: Decision-making

Summary: the vasis project aims to assess the impact of perceptual, executive and emotional factors on decision-making in the context of pedestrian crossing in an industrial environment involving autonomous vehicle traffic (forklift).


Eligibility criteria:
inclusion criteria: * subjects aged 18 to 45 * no objection following submission of a non-objection form indicating that the subject has understood the purpose and procedures of the study and agrees to participate in the study and to comply with the requirements and restrictions inherent in the study exclusion criteria: * legal incapacity or limited legal capacity * subject unlikely to cooperate with the study and/or poor cooperation anticipated by the investigator * pregnant or breast-feeding women * color-blind subject * history of cardiovascular disease * current psychiatric or neurological disorders (including self-reported diagnoses of epilepsy) * known vestibular disorders (prone to frequent dizziness or vertigo) * headaches or migraines * deafness * subjects under the influence of psychotropic substances (alcohol, drugs) * motor disorders likely to prevent crossing
retinal vascular reactivity in subjects with newly diagnosed glaucoma before and after selective laser trabeculoplasty

Conditions: Glaucoma

Summary: the purpose of this study is to assess retinal blood flow and vascular reactivity in patients with newly diagnosed primary open angle glaucoma pre- and post-primary selective laser trabeculoplasty(slt). canon laser blood flowmeter will be used for the assessment of retinal blood flow.

we previously found that vascular reactivity improved after short term treatment with dorzolamide drops. it is not clear whether this improvement was a direct effect of the medication or secondary effect of the decrease in iop. we would like to see the change of vascular reactivity before and after slt, which will decrease the intraocular pressure without pharmacologic effect.

Eligibility criteria:
inclusion criteria: 1. age 40-75 years (male or female) 2. best corrected visual acuity of at least 20/40 3. no previous treatment for glaucoma 4. ametropia less than ±6.0 ds and ±2.5 dc) 5. non-smoker 6. no cardiovascular/respiratory disorders exclusion criteria: 1. past history of diabetes and cerebrovascular accident 2. vascular occlusive disease affecting the ocular circulation such as: diabetic retinopathy, retinal vein occlusion and retinal artery occlusion 3. previous intraocular surgery 4. ocular media opacities limiting the use of the imaging tests

Keywords: blood flow glaucoma slt
randomized trial to evaluate the effectiveness of a mindfulness based intervention (mbsr) for patients suffering from migraine

Conditions: Migraine

Summary: patients suffering from migraine will be randomly allocated to one of two different behavioral interventions: * mindfulness based stress reduction (mbsr) an eight week intervention program based different meditation \& yoga techniques and teaching information regarding the relationship between stress and health. * into an active control group teaching three times within eight weeks relaxation techniques (progressive muscle relaxation pmr) and giving psychoeducation on migraine. the investigators will measure the frequency and intensity of migraine attacks before during and after the intervention as well as secondary variables on quality of life and psychological functioning. the hypothesis is that patients allocated to the mbsr intervention will reduce the frequency of their migraine attacks compared to the active control group and compared to their own baseline.

sixty patients suffering from migraine will be randomly allocated to one of two different behavioral interventions: (i) mindfulness based stress reduction (mbsr) an eight week intervention program based different meditation \& yoga techniques and teaching information regarding the relationship between stress and health. or (ii) into an active control group teaching three times within eight weeks relaxation techniques (progressive muscle relaxation pmr) and giving psychoeducation on migraine. the investigator will measure the frequency and intensity of migraine attacks before during and after the intervention by headache diaries as well as secondary variables on pain sensation, psychological well being, generic quality of life, pain regulation, pain acceptance, mindfulness, compliance and satisfaction with the intervention. the hypothesis is that patients allocated to the mbsr intervention will reduce the frequency of their migraine attacks compared to the active control group and compared to their own baseline.

Eligibility criteria:
inclusion criteria: * migraine for at least 6 months * commandment of german language * 3-8 migraine attacks per month * willingness to participate in a behavioral intervention and to conduct the daily homework * if patients take a drug as prophylaxis for migraine no change of drug for at least three months and no change of dose for at least one month prior to enrollment exclusion criteria: * psychiatric disorders at the time of enrollment * addiction * participation in other trials * prior experience with mbsr * migraine related to the ovary cycle * abuse of acute medication for migraine * other psychological disorders which impair the communication and interaction with the patient

Keywords: migraine headache
early detection and treatment of respiratory sleep disorders in children with down syndrome

Conditions: Down Syndrome; Obstructive Sleep Apnea of Newborn

Summary: interventional, comparative, open label, single-center study to demonstrate that an early (from 6 months of age) and systematic (every 6 months) screening of obstructive sleep apnea (osa) by polysomnography (psg) in children with down syndrome during the first 3 years of life is associated with an improved neurocognitive development at the age of 3 years.


Eligibility criteria:
inclusion criteria : down syndrome age 6 months or less for the study group age 30 to 36 months for the standard care group living in paris or paris area (75, 77, 78, 92, 93, 94, 95) parents or legal representative agreeing with the study requirements and able to understand, date and sign the informed consent form before study enrollment french language is native mother tongue exclusion criteria : gestationnel age \< 36 completed amenorrhoea weeks patient who have or had acute cns suffering signs patients with down syndrome already had continuous positive airway pressure treatment for osa patients participating in another clinical study or for whom a participation to another biomedical research is expected before the end or their follow-up
ramanspectroscopy in barrett's esophagus

Conditions: Barrett's Esophagus

Summary: this study is being done to see if a new device, called near-infrared raman spectroscopy, can provide similar information as that obtained from taking biopsies of the lining of your barrett's esophagus

in the search for means to enhance the surveillance of be, optical spectroscopy is emerging as a candidate with high potential. optical spectroscopic techniques measure specific light-tissue interactions, such as fluorescence, elastic scattering, and raman (inelastic) scattering, which provide objective and quantitative diagnostic information about the molecular and/or structural status of tissue. moreover, optical spectroscopy has the capacity to identify tissue pathology in situ in a rapid and non-destructive fashion. among the optical spectroscopic techniques, near-infrared raman spectroscopy (nirs) is particularly promising because of the wealth of molecular-specific information contained in its spectra

Eligibility criteria:
inclusion criteria: * closed to further enrollment

Keywords: barrett's esophagus
phase iia study of ublituximab in participants with relapsing forms of multiple sclerosis

Conditions: Multiple Sclerosis

Summary: this study evaluates the use of single agent ublituximab, a novel monoclonal antibody, in participants with relapsing forms of multiple sclerosis.


Eligibility criteria:
inclusion criteria: * diagnosis of relapsing multiple sclerosis * active disease * greater than or equal to (≥) 2 relapses in prior 2 years or 1 relapse in the year prior to screening and/or ≥1 gadolinium (gd) enhancing lesion exclusion criteria: * treatment with anti-cluster of differentiation 20 (cd20) monoclonal antibody within the last 12 months * treatment with alemtuzumab within the last 12 months * pregnant or nursing mothers

Keywords: multiple sclerosis
phase iii daclatasvir, sofosbuvir, and ribavirin in cirrhotic participants and participants post-liver transplant

Conditions: Hepatitis C

Summary: this trial was open to participants who had received a liver transplant or had cirrhosis due to chronic hcv. all subjects were treated with daclatasvir+sofosbuvir+ribavirin and were followed for 24 weeks post treatment. under certain conditions, the treatment duration could have been extended for cirrhotic participants. the study tested the efficacy and safety of this combination for treatment of hcv in cirrhotic and post transplant patients.


Eligibility criteria:
for more information regarding bms clinical trial participation, please visit www.bmsstudyconnect.com inclusion criteria: * participants must be able to understand and agree to comply with the prescribed dosing regimens and procedures, report for regularly scheduled study visits, and reliably communicate with study personnel about adverse events and concomitant medications * participants chronically infected with hepatitis c virus (hcv) genotype 1, 2, 3, 4, 5, or 6 with hcv rna viral load of ≥10,000 iu/ml at screening * participants may be treatment-naïve or treatment-experienced * cirrhotic participants must have cirrhosis confirmed by biopsy, fibroscan or fibrotest and aspartate aminotransferase platelet ratio index (apri) criteria as outlined in the protocol * post-transplant participants must be at least 3 months post-transplant with no evidence of moderate or severe rejection exclusion criteria: * history of multi-organ transplant, with the exception of dual transplantation of the liver/kidney, is prohibited * current or known history of cancer (with the following exceptions: in situ carcinoma of the cervix, adequately treated basal or squamous cell carcinoma of the skin, or hepatocellular carcinoma within milan criteria for transplantation) within 5 years prior to screening * evidence of an ongoing medical condition contributing to chronic liver disease other than hcv (such as, but not limited to: hemochromatosis, autoimmune hepatitis, metabolic liver disease, alcoholic liver disease, or toxin exposures) * history of hiv infection or chronic hepatitis b virus (hbv) as documented by hbv serologies (e.g., hbsag-seropositive). participants with resolved hbv infection may participate (e.g., hbcab-seropositive with concurrent hbsag-seronegative) * active hospitalization for decompensated liver disease
a study in taiwan based on medical records that looks at the occurrence of flare-ups in patients with chronic obstructive pulmonary disease (copd) who started laba/lama or lama treatment

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: study to collect the data on chronic obstructive pulmonary disease (copd) patients who were administered with long-acting beta-agonist/ long-acting muscarinic antagonist (laba/lama) (fixed-dose combination (fdc) or free combo) or lama treatment


Eligibility criteria:
inclusion criteria: patients who fulfil all the following criteria are included. 1. patients who diagnosed with copd who were prescribed with laba/laba (fdc or free combo) as a new initiation or switching from other therapy (i.e., single/dual/triple), or newly receiving lama treatment for 3 months at least prior to 30 june 2018 2. male or female patients ≥ 40 years of age exclusion criteria: 1. patients who meet the following criterion are not included. * patients with documented diagnosis of bronchial asthma, asthma-copd overlap syndrome (acos), bronchiectasis, cystic fibrosis, or lung cancer
videoconferencing between ambulances and physician manned rapid response vehicles, effects on on-site patient treatment and patterns of referral

Conditions: All Acutely Ill or Injured Patients Receiving Care by Ambulance Personnel

Summary: physician manned rapid response vehicles are a limited resource in the prehospital handling of acute patients. in this study mobile videoconferencing between ambulances and the rapid response vehicles enables patient consultation at a distance. video consultation between patient and the prehospital physician can take place when the patient is at home or in the ambulance. the primary aim of this study is to examine the effect of video consultation between physician manned rapid response vehicles and patients receiving treatment by ambulance personnel on the number of patients receiving final treatment on-site in the pre-hospital setting


Eligibility criteria:
inclusion criteria: * all patients receiving prehospital care by ambulance personnel * must receive either telephone or video consultation by physician in rapid response vehicle exclusion criteria: -
cognitive stimulation for elderly bipolar patients

Conditions: Bipolar Disorder; Cognitive Impairment; Age-related Cognitive Decline

Summary: age is a major risk factor for the development of cognitive disorders and neurodegenerative pathologies. cognitive disorders during the phases of bipolar disease are known to exist, and alterations increase significantly after the age of 65. drug treatments seem to have only a limited effect. a cognitive stimulation program has proven his benefit to patients over 65 with neurodegenerative diseases (israel, 2004). we propose to evaluate this cognitive stimulation program that we have adapted to bipolar disease.

bipolar disorders, which belong to the category of mood disorders, are the 6th leading cause of disability in the world. cognitive disorders are known to exist during the phases of bipolar disease, and alterations increase significantly after the age of 65. recent studies have shown that attention, memory and executive function impairments are the main causes of cognitive disorders. residual symptoms have a significant impact on the risk of relapse into bipolar disorder and on quality of life. cognitive stimulation (cs) is a pedagogical approach based on the idea that cognitive skills contribute to personal development in the same way as psychological and social factors. this study aims at assessing a cognitive stimulation program initially developed for patients with neurodegenerative diseases, and adapted to bipolar disease. this program will be compared to the usual practice consisting in consultation with psychiatrist and sometimes in intervention of home nurses.

Eligibility criteria:
pre-inclusion criteria: * age \> 65 years old * diagnosis of bipolar illness for more than 10 years * euthymic phase * understands and speaks french * free, informed and express consent inclusion criteria: * mild to moderate neuro-cognitive impairments (mms test : 16 ≤ score \< 26) exclusion criteria: * illiteracy * patient participating in other therapeutic workshops (e. g. psycho-geriatric day hospital care, etc.) * persons deprived of their liberty by a judicial or administrative decision * persons of full age who are subject to a legal protection measure * persons unable to consent * persons who are not members of or beneficiaries of a social security scheme * patient's refusal to participate in the study
correction for kyphotic posture for improving balance in cerebral palsy

Conditions: Kyphosis

Summary: children with spastic diplegia are at an increased risk of spinal deformities. the most common types of these spinal deformities are scoliosis and kyphosis. thoracic hyper-kyphosis may adversely affect balance in children with cerebral palsy . the treatment approaches for hyper-kyphosis involved both conservative and surgical treatments. the conservative approach includes corrective exercises, positioning, and spinal braces. this study aimed to evaluate the effect of conservative orthotic management for kyphotic posture on balance control, and fall risk in cerebral palsied children of spastic diplegia.

kyphosis is a posterior convexity of the spine. children with cerebral palsy show a higher probability of progression of the kyphotic curve. if it is not adequately treated, it becomes fixed where it requires surgical management. children with cerebral palsy have more probability to balance impairment and falls than normal children and the consequences of that fall are great. the current studies do not properly examine the effectiveness of conservative orthoses on the therapeutic management of kyphosis in children with cerebral palsy. also, there is a shortage of studies that evaluate how correction of the thoracic kyphosis influences the balance performance and fall risk in children with cerebral palsy. theratogs orthosis which consists of an orthotic undergarment and external strapping system has been designed to provide a soft and passive body compression to maintain a typical body postural alignment and to improve posture control. therefore, the objective of this study was to investigate how the correction of dorsal hyper-kyphotic posture by the theratogs orthotic system could influence balance control, and fall risk in cerebral palsied children of spastic diplegia.

Eligibility criteria:
the inclusion criteria were: * children with a diagnosis of cerebral palsy of spastic diplegia. * they were all between 8 and 10 years old, of both sexes. * the degree of spasticity in the affected upper and lower extremity, was ranged between grades (1, 1+\&2) according to modified ashworth scale (mas). * children were cognitively able to understand and follow instructions. * the levels of their gross motor function were between level i and ii according to the gross - motor function classification system (gmfcs). * they were able to stand alone for five to ten minutes without any assistance. * the degree of the spinal kyphosis in the sagittal plane did not exceed 45° (cobb's angle). the exclusion criteria were: * children with any orthopedic condition or fixed deformity that interfere with the spinal and limbs functions. * children who demonstrated allergic reactions to the adhesive tape or any other materials used in this study. * children with surgical interference for the lower limb and spine within the previous 2 years. * children with seizures, visual impairments, or perceptual problems.

Keywords: kyphosis balance fall risk
efficacy of the integration of digital therapeutics and home-based cardiac rehabilitation in high-risk post-pci patients

Conditions: Coronary Artery Disease; Myocardial Infarction

Summary: the dtx-hbcr trial will randomize 366 high-risk patients who undergo pci at the west china hospital of sichuan university to either the 6-month dtx-guided hbcr group (intervention group) or the 6-months usual care group (control group) in a parallel-arm randomized controlled trial. the primary outcome is the difference between the intervention group and control group in walk distance on the 6-minute walk test (i.e., functional capacity) at 6 months post randomization. the key secondary outcomes include improvements in cardiovascular risk factor control, quality of life, psychological status, physical activity, major adverse cardiovascular events, and medication adherence. this study aims to evaluate the dtx-guided hbcr, a software-driven, multidisciplinary health intervention as an alternative to traditional in-center cr in patients with high-risk patients following percutaneous coronary intervention (pci) compared with usual care alone.


Eligibility criteria:
inclusion criteria: * to be eligible to participate in this study, a participant must meet all of the following criteria: 1. women or men, the ages of 18 and 75 years. 2. have sufficient reading and writing language skills in chinese. 3. be willing to participate the study and sign informed consent. 4. patients must have at least one clinical feature and one angiographic feature: a. clinical features: age ≥ 65 years, female sex, troponin positive acute coronary syndrome, established vascular disease (prior myocardial infarction, coronary revascularization or peripheral arterial disease) , diabetes mellitus requiring medication and chronic kidney disease (estimated glomerular filtration rate \< 60 ml/min/1.73 m2 or creatinine clearance \< 60 cc/min) . b. angiographic features: multivessel coronary artery disease, total stent length \> 30 mm, thrombotic target lesion, bifurcation lesion requiring two stents, obstructive left main or proximal left anterior descending lesion and calcified target lesion requiring atherectomy. exclusion criteria: * a potential participant who meets any of the following criteria will be excluded from participation in this study: 1. contraindications to exercise rehabilitation (e.g., untreated ventricular tachycardia, severe heart failure (new york heart association class iii or iv heart failure, or ejection fraction \< 40%), uncontrolled hypertension or hypotension, active hemorrhage, severe liver failure, significant exercise limitations). 2. vision, hearing, cognition-related or mental impairment leading to inability to cooperate. 3. patients with established planned phase ii pci. 4. having pre-existing comorbid disease with a life expectancy of \< 1 year. 5. poor compliance and unable to complete the expected follow-up. 6. unable to access wechat via a smartphone after training.
acute effects of exercise in smokers with schizophrenia

Conditions: Tobacco Dependence; Cigarette Craving; Smoking Behavior

Summary: people with schizophrenia have two- to three-times the mortality risk of the general population. this is primarily due to their unusually high rates of cigarette smoking, as well as other cardiovascular risk factors such as physical inactivity, obesity, high blood cholesterol and diabetes. effective smoking treatments are needed to reduce morbidity and mortality in this population. over a dozen experimental studies indicate that walking and other forms of exercise acutely reduce cigarette craving, nicotine withdrawal symptoms and smoking behavior in non-psychiatric smokers. however, the effects of acute exercise on smoking measures have not been studied in smokers with schizophrenia. this study will use a within-subjects, repeated-measures design, in which participants will undergo 4 laboratory sessions (order counterbalanced across participants): (1) smoking cues followed by exercise, (2) smoking cues followed by passive activity, (3) neutral cues followed by exercise, (4) neutral cues followed by passive activity. outcome measures include cigarette craving, nicotine withdrawal symptoms, mood and smoking behavior. if the results of this study indicate that walking acutely reduces craving and smoking in smokers with schizophrenia, the next step in this research would be to test the effectiveness of a smoking cessation intervention that incorporates exercise bouts as a behavioral strategy for improving smoking cessation rates in this population.


Eligibility criteria:
inclusion criteria: * diagnosis of schizophrenia * smoke at least 20 cigarettes per day * less than 60 min moderate-intensity exercise per week exclusion criteria: * medication changes in past 4 weeks * unable to give informed consent to participate * alcohol/drug screen * pregnant or nursing * receiving or seeking immediate smoking treatment

Keywords: psychiatric comorbidity craving tobacco