Kornimate/medical-research-clean huggingface dataset:
dynamic neuromuscular stabilization exercises in women with urinary incontinence

Conditions: Stress Urinary Incontinence (SUI); Dynamic Neuromuscular Stabilization; Pelvic Floor Muscle Training; Urinary Symptoms; Biofeedback Training

Summary: stress urinary incontinence (sui) is defined by the international continence society as the complaint of involuntary leakage of urine during physical exertion, including sports activities, or during sneezing or coughing. in continent women, an automatic response-namely, a reflex pelvic floor muscle (pfm) contraction, also known as pre-contraction-occurs either prior to or during physical exertion. although there is strong evidence supporting the effectiveness of pelvic floor muscle training (pfmt) in the treatment of sui, there has been a growing interest in exploring alternative exercise-based interventions. dynamic neuromuscular stabilization (dns) is a manual and rehabilitative approach developed by professor pavel kolar. it is grounded in the scientific principles of developmental kinesiology and aims to optimize the function of the movement system. currently, dns is successfully employed in the rehabilitation of various neurological, musculoskeletal, pediatric, and sports-related injuries. dns incorporates the subconscious and synergistic activation of the deep core muscles responsible for intra-abdominal pressure (iap) regulation and spinal stability-namely, the diaphragm, transversus abdominis, multifidus, and pelvic floor muscles-as well as the global musculature. considering the potential mechanisms of dns, we hypothesize that dns exercises, through iap regulation directed toward the pelvic cavity and contributing to stabilization, could serve as an effective and innovative approach for women with sui. the hypotheses of this study are as follows: h1.1: dns is as effective as pfmt in reducing urinary symptoms in women with sui. h1.2: dns is as effective as pfmt in improving pfm function in women with sui.


Eligibility criteria:
inclusion criteria: * female gender, * voluntary participation in the study, * aged between 18 and 62 years, * ability to read and write in turkish, * no mental disorders that would impair cooperation or comprehension, * complaint of stress urinary incontinence (sui) or stress-predominant mixed urinary incontinence. exclusion criteria: * prior history of pelvic floor muscle training, * presence of any neurological disorder, * pelvic organ prolapse stage ii or higher, * presence of fecal incontinence, * pregnancy, * lower extremity conditions that may affect pelvic alignment (e.g., leg length discrepancy, total hip arthroplasty), * active lower urinary tract infection, * presence of respiratory disorders such as chronic obstructive pulmonary disease or asthma, * history of hysterectomy.
predicting tumor origin based on deep learning of lymph node puncture cytology

Conditions: Lymph Nodes With Tumor Metastasis

Summary: in this study, the investigators aimed to construct a deep learning diagnostic model that uses cytological images to predict primary unknown tumor origins in patients with tumors combined with lymph node metastases. after the model is constructed, the model will be validated by a large-scale test set to test the model performance. the investigators also propose to compare the performance of the constructed model in diagnosing cytology smears compared to human pathologists.


Eligibility criteria:
inclusion criteria: * from west china hospital of sichuan university (october 1, 2008-august 31, 2024) with corresponding clinical data, including age, sex, specimen puncture site, pathologic diagnosis, pathologic type, whether immunocytochemistry was added, clinical diagnosis, lesion site, co-morbidities, history of malignancy, treatment modality, occurrence of postoperative complications, total number of days of hospitalization postoperatively, and survival time; * from the department of pathology of the first affiliated hospital of zhengzhou university, the sichuan provincial cancer hospital, and the cancer hospital of the chinese academy of medical sciences (january 1, 2020-august 31, 2024) with corresponding clinical data, including age, sex, specimen puncture site, pathologic diagnosis, pathologic type, whether immunocytochemistry was added, clinical diagnosis, lesion site, co-morbidities, history of malignancy, treatment modality, occurrence of postoperative complications, total number of days of hospitalization postoperatively, and survival time. exclusion criteria: * images lacking any supporting clinical or pathologic evidence to support a primary origin and its corresponding clinical information; * blank, poorly focused, and low-quality images containing severe artifacts and their corresponding clinical information.

Keywords: primary unknown tumor origin deep learning cytopathology
far infrared therapy on peripheral artery disease in hemodialysis patients

Conditions: Peripheral Artery Disease

Summary: the prevalence of peripheral artery disease (pad) defined as ankle-brachial index (abi) less than 0.9 was about 15\~30% in patients with end stage renal disease (esrd), which was higher than those with normal renal function. a lower abi and a higher brachial-ankle pulse wave velocity (bapwv) are good markers to predict the risk of pad and atherosclerosis respectively. in addition, bapwv\>2,100 cm/s was shown to be related to potential pad. abi \<0.9 was positively associated with vascular access failure in hemodialysis (hd) patients and our previous study has demonstrated that far infrared (fir) therapy can improve access flow and unassisted patency of atrioventricular (av) fistula. the aims of this study are to evaluate (1) the frequency of and (2) risk factors associated with abnormal abi and pwv as well as (3) the effect of fir on abi and pwv and markers related to endothelial dysfunction in hd patients.

in this study, 300 hd patients will be enrolled to receive abi and bapwv and about 90 patients (30% according to the literature review) who have abnormal abi (\ 2100 cm/sec) will be randomly allocated to fir group (receiving fir therapy for 40 minutes thrice weekly) and control group (without fir therapy). in patients with abnormal abi or bapwv, the effect of single or one-year treatment of fir on the following items will be studied: (1) abi, (2) bapwv and (3) markers related to endothelial dysfunction \[including low and high density lipoprotein cholesterol (ldl and hdl), asymmetric dimethylarginine (adma), hypersensitive c-reactive protein (hscrp), matrix metalloproteinase-9 (mmp-9)\]. the effect of fir on pad or cardiovascular events during one year of follow-up will also be studied. this study will allow us to identify the frequency of and the risk factors associated with abnormal abi \& pwv as well as the effect of single or one-year fir therapy on abi \& pwv in hd patients.

Eligibility criteria:
inclusion criteria: * in this study, we will include 300 patients who have received 4 hours of maintenance hd therapy three times weekly for at least 3 months exclusion criteria: * patients with life expectancy less than 1 year * patients with history of active malignancy

Keywords: ankle-brachial index (abi) brachial-ankle pulse wave velocity (bapwv) far infrared therapy (fir) hemodialysis (hd) peripheral artery disease (pad) peripheral artery disease in hemodialysis
t-wave alternans in acute myocardial infarction: an evaluation of the time of testing on its prognostic accuracy

Conditions: Myocardial Infarction; Arrhythmias

Summary: t-wave alternans is an electrocardiographic finding that has been shown to predict the occurrence of future cardiac arrhythmias in patients who have had a heart attack. what is unknown about t-wave alternans testing is when is the best time to perform the test. in most studies, t-wave alternans testing is conducted 4 weeks or more after a heart attack. it is unknown if t-wave alternans testing performed prior to hospital discharge in heart attack patients is reliable. the objective of this project is to determine the diagnostic accuracy of t-wave alternans testing performed prior to hospital discharge and again at 30 days after hospital discharge in patients who have suffered a heart attack.


Eligibility criteria:
inclusion criteria: * acute myocardial infarction (mi) confirmed by electrocardiographic and or/ enzymatic criteria * patients with a left ventricular ejection fraction of 45% or less exclusion criteria: * patients with (1) atrial fibrillation, (2) pacemaker rhythm, (3) left bundle branch block, (4) class iii-iv heart failure, (5) inability to achieve a target heart rate with exercise or handgrip stress or (6) spontaneous sustained ventricular tachycardia/ventricular fibrillation will be excluded * patients with recurrent angina pectoris, mi, coronary revascularization, or any other adverse cardiovascular event in the 30 days following their initial mi will also be excluded

Keywords: myocardial infarction arrhythmia t-wave alternans
comparison of frailty screening performance and predictive validity of adverse health outcomes in breast cancer patients using frailty screening tools

Conditions: Frailty Syndrome

Summary: this study uses the physical frailty phenotype (pfp) as the diagnostic criterion for frailty and aims to explore the frailty screening scale frail (the frail scale), tilburg frailty index (tfi) and geriatric screening. screening performance of tool-8 (geriatric-8, g-8) in breast cancer patients, to compare the predictive validity of different frailty screening scales for adverse health outcomes in breast cancer patients, and to select appropriate frailty screening methods for breast cancer patients in my country screening scale.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of breast cancer * age ≥50 years old * the treatment plan discussed by mdt includes surgery and chemotherapy * can walk on their own (with the assistance of walking aids) exclusion criteria: * communication disorders * mental disorders that can't cooperate normally * combined with other malignant tumours * terminal stage of the disease
short-term recovery after trapeziectomy and tmc prosthesis: a diary study

Conditions: Arthrosis of First Carpometacarpal Joint

Summary: rationale: the trapeziometacarpal (tmc) joint is one of the most common areas in the hand and wrist to develop osteoarthritis (oa). currently, the two most widely used procedures are the trapeziectomy and the tmc-joint arthroplasty, both with their own pros and cons. no studies have demonstrated superiority of tmc-joint arthroplasty over gold-standard trapeziectomy. and no clinical studies show short-term recovery and patient experience after trapeziectomy or tmc-joint arthroplasty. objective: to gather insight in short-term recovery and patient experience after a trapeziectomy or tmc prosthesis regarding pain, pain medication, function and quality of life. study design: a prospective observational cohort diary study. study population: in total 200 subjects with tmc-joint osteoarthritis will participate: 100 subjects will have trapeziectomy and 100 subjects will have tmc-joint arthroplasty main study parameters/endpoints: the main study parameters are the pain, function and quality of life during the first 8 weeks after surgery. nature and extent of the burden and risks associated with participation, benefit and group relatedness: subjects will have no direct benefit from participation in this study. subjects will only complete a diary and questionnaires for this study. therefore, we expect no risks from participation. the burden for subjects consists of approximately five minutes daily for the diary in the first eight weeks after surgery.


Eligibility criteria:
inclusion criteria: * failed conservative treatment for osteoarthritis * planned for trapeziectomy or tmc-joint arthroplasty * age 18-75 years * willing and able to comply with the postoperative functional assessment and to participate in a rehabilitation schedule exclusion criteria: * mentally disabled patients * active infection * current malignancy * infiltration (corticoids \< 3 months) the following criteria is specific for the tmc-joint arthroplasty group and is an addition to the criteria mentioned above: * trapezium height \< 8 mm

Keywords: trapeziectomy diary tmc-arthroplasty osteoarthrosis
balloon blowing breathing exercise in school-age children with asthma.

Conditions: Asthma in Children

Summary: this study were to investigate the effects of balloon blowing breathing exercise on respiratory muscle strength and asthma symptoms in school-age children with asthma.

thirty school-age children with asthma aged 7 - 12 years old who were admitted at the outpatient examination room, phramongkutklao hospital, divided into 2 groups. the first group was 15 individuals trained with sustained maximal inspiration (smi) breathing exercise while the second group was 15 individuals training with balloon-blowing breathing exercise. participants were required to complete breathing exercise 5 times per week for 8 weeks. five breathing exercises were taken for 8 weeks before and after the experiment. physiological characteristics data, pulmonary function, respiratory muscle strength, and asthma symptoms variables were comparatively analyzed before and after training. the mean values of variables before and after the experiment of each group were analyzed using paired t-test.

Eligibility criteria:
inclusion criteria: * has been diagnosed with asthma for at least 6 months. the severity rating is not higher than level 2, (forced expiratory volume in one second; fev1 is at least 80%) * no history of diabetes, heart disease, and musculoskeletal disease * did not participate in exercise training for more than 20 minutes 3 times a week or more in the 6 months prior to the start of data collection. exclusion criteria: * patient with a history of exercise-induced asthma. * recurrent of acute exacerbation * cannot participate at least 80% of training program (≤ 32 sessions of 40 sessions) * unwilling to continue practicing

Keywords: balloon blowing breathing respiratory muscle strength school-age children with asthma sustained maximal inspiration (smi) breathing asthma symptoms
use of an allograft set-up (sclerfix) as replacement of sclera graft for support of enucleation implant

Conditions: Enucleated; Eye; Eye Cancer

Summary: the purpose of this open, monocenter pilot trial is to evaluate the tolerance of the sclerfix product, an allograft of umbilical cord lining membrane, in the reinforcement of ocular implants in patients who underwent enucleation due to an eye malignant tumor resection.

as scleral graft is forbidden in france, it cannot be used for support of enucleation implants. this study investigational product, sclerfix, was developed to substitute scleral grafts in those cases.

Eligibility criteria:
inclusion criteria: * men or women between 45 and 85 years old, presenting an enucleation caused by malignant tumor resection. * oncological treatment compatibility with enucleation and intra-orbital implant. * surgery requiring the placement of an enucleation implant. * persistence of the oculomotor muscles allowing their insertion into the tissue. * patient with social security coverage. * consenting and informed patient. exclusion criteria: * pregnant or breast-feeding women: women of childbearing age were asked to undergo a pregnancy test before being enrolled into the study and to use an effective birth control method. * patient presenting an infectious risk (neutropenia, active local infection, immunodeficiency). * patient with autoimmune disease. * proton-therapy / radiotherapy of the eye before healing. * patient with oculomotor muscles invasion or non-attachment of these muscles. * allergy to contrast agents used in radiology. * patient under legal guardianship. * patient not benefiting from the social security cover.
nutritional supplement's effects on cognition

Conditions: Dietary Supplement; Cognition; Healthy

Summary: this is a prospective, placebo controlled study, examining the effects of dietary supplement's effects on cognition and confirming safety.

the objective of this prospective, placebo controlled, double-blinded, parallel-group study is to examine the effects of dietary supplement containing grape juice extract, astaxanthin, and vitamin e over 12 week consumption on cognitive performance and self report results based on questionnaires. furthermore, an evaluation of general well-being, mood, markers of oxidative stress, neurogenesis (bdnf), eye health, skin health, skin carotenoid concentrations, and safety measurements will be assessed.

Eligibility criteria:
inclusion criteria: * health individuals * residing in independent living accommodations * subjective report of memory or attention problems by answering 'yes' to the following questions: do you have problems with your memory, attention, or concentration? * non-smoker * body mass index (bmi) between 18-35 kg/m2 * no plan to commence new treatments over the study period * understand, willing and able to comply with all study procedures * willing to provide a personally signed and dated informed consent form detailing all pertinent aspects of the study exclusion criteria: * diagnosis of dementia based on the revised national institute on aging-alzheimer's association (nia/aa) criteria * a score below the 5th percentile for age, education, and gender on the telephone interview for cognitive status (tics-m) * suffering from recently diagnosed or unmanaged medical conditions including but not limited to diabetes, hyper/hypotension, cardiovascular disease, gallbladder disease, autoimmune disease, endocrine disease, or cancer/malignancy * diagnosis of a psychiatric disease (other than mild-to moderate depression of anxiety) and/or neurological condition/disease (e.g. parkinson's, alzheimer's disease) * history of paralysis, stroke or seizures or head injury (with loss of consciousness) * regular medication intake including but not limited to anticholinergics, acetylcholinesterase inhibiters, or steroid medications. * taking vitamins or herbal supplements that are reasonably expected to influence study measures * in the last 6 month, commenced or changed the dose of nutritional and/or herbal supplements that may impact on treatment outcome * alcohol intake greater than 14 standard drinks per week * current or 12-month history of illicit drug abuse * pregnant women, women who are brest feeding, or women who intend to fall pregnant * any significant surgeries over the last year * planned major lifestyle change in the next 3 months

Keywords: dietary supplement cognition memory mental stress wellbeing antioxidant astaxanthin grape juice extract
bevacizumab for the treatment of corneal neovascularization

Conditions: Corneal Neovascularization

Summary: the purpose of the current study is to assess the efficacy and safety of the inhibitory effect of bevacizumab (avastin) with different routes including topical and subconjunctival application on corneal neovascularization in the human eyes.

the compassionate off-label use of bevacizumab as well as the potential risks, benefits, and adverse effects of this medication are discussed extensively with each patient. to further minimize systemic absorption, silicone punctual plugs are placed in the lower eyelids. one group of patients apply topical bevacizumab, 1.0%(10mg/ml), 4 times of day. the other group of patients received subconjunctival injection of bevacizumab(2.5mg/0.1ml) once. the patients are examined at 1day, 1week, 2weeks, 3weeks, and 1month, then monthly till the corneal neovascularization are gone or reduced to some degrees. best-corrected visual acuity, slip-lamp examination, tonometry, external photography, pachymetry, specular microscopy (if possible), and systemic blood pressure are completed at all visits.

Eligibility criteria:
inclusion criteria: * significant unilateral or bilateral corneal neovascularization that extending over the limbus at least 2mm. * the underlying etiologies that caused corneal neovascularization included post penetrating keratoplasty (pkp), ocular surface reconstruction , trauma, infectious or non-infectious corneal ulcer. * corneal neovascularization induced lipid keratopathy, corneal edema, or irregular corneal surface. the best-corrected visual acuity was less than 20/25. * post-psp or ocular surface reconstruction corneal neovascularization that had no associated lipid keratopathy, no corneal edema, or corneal irregularity. but the neovascularization was highly possible to cause graft rejection. * the corneal neovascularization was refractory to other medical treatment. * the patient had received pkp or other corneal surgeries mort than half a year ago and was not in the acute post-operation phase. * the patient had no active endophthalmitis, glaucoma with uncontrolled intraocular pressure, or vitreoretinal diseases. * the patient signed inform consent to have regular follow up and treatment. exclusion criteria: * the neovascularization had clinical improvement three months before the first injection. * the lipid keratopathy had clinical improvement three months before the first injection. * the patient that suspected to have poor visual outcome or had already been light sense negative glaucoma patient that had uncontrolled intraocular pressure. * poor corneal epithelialization. * patient that had systemic disease which was not suitable for bevacizumab use. * pregnant patient.

Keywords: corneal neovascularization bevacizumab
evaluation of the efficacy of aromatherapy on the well-being of healthcare professionals

Conditions: Healthcare Professionnals

Summary: the main objective is to evaluate the efficacy of aromatherapy (inhaler sticks) on the well-being of healthcare professionals practicing in medical and surgical intensive care unit, operating room/anesthesia and emergency departments

the secondary objectives of this study are : 1. to evaluate the efficacy of aromatherapy on anxiety of healthcare professionals; 2. to evaluate the efficacy of aromatherapy on stress symptoms of healthcate professionals; 3. to assess compliance with aromatherapy. conduct of research: all participants included in the study will receive the study treatment (essential oils mixtures in inhaler sticks for 2 months) and the control (no intervention for 2 months), in random order. at inclusion and at the end of each period, questionnaires of well-being, anxiety and stress will be completed.

Eligibility criteria:
inclusion criteria: * healthcare professional ; * working in a medical or surgical intensive care unit or in a operating room/anesthesia unit or in the emergency department; * agrees not to use any topical, oral or inhaled essential oils during the two study periods, other than those specified in the study protocol; * written informed consent; exclusion criteria: * pregnant or breastfeeding woman; * known allergies to essential oils; * asthma; * scheduled departure from the unit; * antidepressant treatment or anxiolytic treatment; * taking topical, oral or inhaled essential oils durink the week prior to inclusion.

Keywords: aromatherapy stress anxiety quality of life critical care