Kornimate/medical-research-clean huggingface dataset:
hypotension prediction index in living donor liver transplantation

Conditions: Living Donor Liver Transplantation; Hypotension

Summary: the hypotension prediction index via the edwards hemosphere advanced monitoring system is monitored in living donor liver transplantation recipients. the hypotension prediction index is analyzed to verify the performance in predicting hypotensive events.

hypotensive events during surgery and anesthesia occur frequently and are associated with complications such as myocardial infarction, acute kidney injury, and increase in mortality. therefore predicting and preventing hypotension can lead to better outcomes. the hypotension prediction index is monitored with the edwards hemosphere advanced monitoring system in living donor liver transplantation recipients via the radial artery. the monitor is blinded so that the anesthesiologist cannot see the index, and the anesthesiologist manages the blood pressure according to the institution's anesthetic protocol for liver transplantation. after the surgery is done, the hypotension prediction index is analyzed to see how well the index predicted actual hypotension that occured during the liver transplantation surgery. receiver operating characteristic curves are drawn to show the performance of the hypotension prediction index in liver transplantation.

Eligibility criteria:
inclusion criteria: * patients scheduled for living donor liver transplantation aged 20 years and older * patients who understand the trial and have given informed consent exclusion criteria: * patients with arrhythmia or pacemaker
valuation of variable dose of docosahexanoic acid for the improvement of the parameters of male fertility

Conditions: Male Infertility

Summary: sperm parameters will be examined before dha (dha=docosahexanoic acid) consumption, after one months and after 2 months taken docosahexanoic acid or placebo.

prospective, randomized, double blind, placebo-controlled intervention study within individuals. assisted reproduction unit and academic research laboratory. one hundred an eighty human semen samples from 60 infertile patients of ivi sevilla clinic were finally included. assessment of oxidative stress, apoptosis, lipid peroxidation, mitochondrial membrane potential, dna fragmentation and standard sperm parameters before and after supplementation with different dha doses (0.5, 1 and 2 g) or placebo for 1 and 3 months.

Eligibility criteria:
inclusion criteria: * 1 year of infertility * \> 10 mill/ml of sperms * motility \< 60% progressive * morphology \< 2% (who 2010) exclusion criteria: no meeting the inclusion criteria.

Keywords: docosahexanoic acid, dna fragmentation male fertility sperm parameters improvements
feasibility of using the "cgm guardian 2" interstitial fluid glucose measurement system in intensive care medicine

Conditions: Hyperglycemia; Hypotension; Shock, Septic

Summary: glycemic imbalances are very common in shock patients admitted to intensive care units. a blood glucose control every 2 hours is routinely performed in patients requiring insulin therapy. in practice, we use a protocol and management software called "cpg" (personalized control of blood glucose). this involves taking capillary samples from the fingertips. in addition to the pain generated, local haematomas and sensitivity disorders have been described. night-time sampling also leads to repeated awakenings. the "cgm guardian 2" system has been validated for the measurement of glucose in interstitial fluid in insulin-dependent diabetic patients. an electrode is placed on the patient's abdomen or arm for up to 6 days. this electrode consists of a needle that is inserted subcutaneously only during the placement. the sugar level is read using a sensor placed on the electrode and an insulin pump (which will not deliver therapy (for our study) and which will be used only as an information reader to know the glucose level and trends). interstitial fluid is automatically drawn from the electrode every minute and averaged every 5 minutes. this device has not yet been validated in resuscitation patients.


Eligibility criteria:
inclusion criteria: * patient in septic shock * arterial hypotension requiring noradrenaline * hyperglycaemia requiring insulin therapy exclusion criteria: * patients under guardianship, curatorship or deprived of liberty * pregnant or breastfeeding women
neuromuscular electrical stimulation in the critically ill

Conditions: Polyneuropathy

Summary: neuromuscular stimulation (nmes) has been used for several years in the rehabilitation of copd (chronic obstructive pulmonary disease) patients (among others) to improve their resistance to efforts in everyday life. in patients in intensive care, it seems to improve strength, reduce the loss of muscle mass, prevent the development of cip / cim (critical illness polyneuropathy / critical illness myopathy) and perhaps even reduce ventilation days, with expected effects on the duration of hospitalization and the long-term functional outcome. although its use could sometimes be limited by the development of peripheral edema and use of vasoconstrictors, the main advantage of this technique is the possibility of being used very early, even in patients that require deep sedation . this is extremely important given that the muscular atrophy process already starts 18h after the onset of invasive ventilation and as signs of impaired nerve transmission are developed in one third of patients at risk within 72 hours. the purpose of the study is to assess the effects, in the short and medium term, of early neuromuscular stimulation in patients who are at higher risk of developing a critical illness polyneuropathy (cip) / critical illness myopathy (cim) spectrum disease. this is a randomized controlled single-blind study comparing a group of patients submitted to nmes early (up to 5 days after admission) versus a control group unstimulated.


Eligibility criteria:
inclusion criteria: * admission in the icu of the brugmann hospital (unit 1020) with an intended icu stay superior to 3 days * aged over 18 years * respiratory assistance needed (invasive and non-invasive ventilation, cpap or optiflow and pao2(arterial oxygen pressure)/fio2(fraction of inhaled oxygen)\<200mmhg) * sapsii (simplified acute physiology score) between entre 35 et 70. exclusion criteria: definitive exclusion criteria: * patients bearing a pacemaker or an aicd (automatic implantable cardioverter/defibrillator ) * bmi superior to 35 * serious neuromuscular pathologies or alterations in the inferior members that make both tights stimulation impossible * pregnant women * patients admitted from friday evening to sunday morning temporary exclusion criteria: * hemodynamic instability (even with filling up and amines: noradrenaline \> 0.5y/kg/min and/or dobutamine \>5y/kg/min and/or adrenaline ivc) * extreme severity with suspicion of death within the first 24 h * pic \> 20 cmh2o * severe agitation (rass \> +1) * curare utilisation within the last 24h

Keywords: critical illness polyneuropathy critical illness myopathy neuromuscular electrical stimulation intensive care unit acquired weakness prevention of critical illness polyneuropathy
defunctioning left-sided colostomy in low anterior resection for rectal cancer

Conditions: Rectal Cancer

Summary: this is prospective, multi centre study evaluating a novel type of defunctioning loop stoma after low anterior resection for rectal cancer. patients will be operated with a complete splenic flexure mobilisation and total mesorectal excision. an anastomosis will be fashioned at the pelvic floor. this will leave a redundant colon which will be brought up and matured in the left iliac fossa. patient bowel function and quality of life will be monitored at baseline and at one year postoperatively, when the stoma will typically have been reversed. dehydration and kidney injury are expected to become infrequent in comparison with the main alternative loop ileostomy. about 20 patients will be included in this pilot study.


Eligibility criteria:
inclusion criteria: * age ≥18 years * capacity for informed consent * planned defunctioning stoma * planned mesorectal excision with anastomosis for rectal cancer exclusion criteria: * manifest atherosclerotic disease (peripheral vascular disease, previous myocardial infarction, angina, etc) * previous oncological colonic resection * defunctioning stoma in situ * intraoperative event leading to bowel resection and subsequent inability to bring out left-sided colostomy without tension on the anastomosis * intraoperative circumstances as judged by the operating surgeon leading to unacceptable risks due to loop colostomy placement (abdominal wall size, short mesentery, other preconditions)
the neural representation of self in depression patients

Conditions: Depression Disorder; Healthy

Summary: to be aware of oneself as a unique entity in the world occurs early in human development and is the prerequisite of normal social functioning. the disturbance of self representation characterizes a variety of mental disorders such as autism and schizophrenia. negative self-bias was found to serve as the core cognitive mechanism of depression disorder. however, there was no evidence to show the reason lead to negative bias. in the current study, investigators hypothesized that the blurring self representation was the neural correlates in depression disorder.

to test investigators' hypothesis, investigators adopted the self-referential task and fmri to investigate the neural representation of self in depression patients, and compared with healthy control.

Eligibility criteria:
inclusion criteria: * patients should be clinical diagnosis of major depression disorder. * healthy control participants should be age-matched with depression group, and should have no history of neurological or psychiatric diagnoses exclusion criteria: * patients who also have bipolar disorder, schizophrenia, anxiety disorder * healthy controls who have history of mental disorders

Keywords: depression, self-referential, neural representation
drain or no drain after thyroid surgery: a randomized clinical trial at mulago hospital

Conditions: Hospital Admission Duration; Postoperative Hematoma Formation; Wound Sepsis

Summary: thyroidectomy is one of the most commonly performed operations in general surgery. available data seem to suggest an association between no-drain usage and a shorter duration of hospital stay. seung et al found that the (following thyroidectomy) time to discharge after thyroidectomy was significantly shorter in the no drain group compared to the drain group. similar results were recorded in a study conducted by davari et al. hyoung et al reported the incidence of hematoma formation post- thyroidectomy to be varying between 0.3%-4.3%. tahsin et al reported that post-thyroidectomy bleeding is as rare as 0.3%-1.0%. the fear of an hematoma enlarging and obstructing the airway and causing difficulty in breathing, prompts many surgeons to use drains routinely after any type of thyroid surgery. the main reason is to drain off a possible postoperative hemorrhage, which may compress the airway and produce respiratory fail

this study will be aimed at comparing the patient outcomes with drain and no-drain insertion methods after thyroidectomy in a resource limited setting. study population: all adult patients aged between 18 to 79 years who attended the endocrinology outpatient clinic and had been diagnosed with goiter. study participants: all adult patients with goiters who were eligible for thyroidectomy inclusion criteria: all adult patients aged between 18 to 79 years with a diagnosis of goiter who consented to participate in the study. exclusion criteria: the investigators excluded patients with goiter who had a history suggestive of bleeding tendencies, recurrent goiter, and thyroid cancer with fixation of the thyroid gland to surrounding structures and had uncontrolled co-morbidities such as diabetes mellitus (dm) and hypertension (ht). inserting a drain after goiter surgery and not inserting a drain is the intervention all participants receive the same treatment

Eligibility criteria:
inclusion criteria: * all adult patients aged between 18 to 79 years with a diagnosis of goiter who consented to participate in the study exclusion criteria: * we excluded patients with goiter who had a history suggestive of bleeding tendencies, recurrent goiter, and thyroid cancer with fixation of the thyroid gland to surrounding structures and had uncontrolled co-morbidities such as diabetes mellitus (dm) and hypertension (ht).

Keywords: drain or no drain thyroid surgery randomized trial
dcd iit: evaluating the safety of utilizing donor hearts from donation after circulatory death (dcd) donors

Conditions: Organ Transplant

Summary: the purpose the research is to evaluate whether patients who receive a donation after circulatory death (dcd) heart for cardiac transplantation using either normothermic regional perfusion (nrp) or direct procurement and perfusion (dpp) have similar outcomes as patients who receive donation after brain death (dbd) heart using standard cold storage. the study will also evaluate whether dcd procured hearts have a meaningful impact on hearts available for transplantation at our center.

in the u.s., heart donation occurs after a person has been declared brain dead and is called a donor after brain death (dbd). in these patients, the heart continues to beat and pump blood throughout the body. after life support is withdrawn, organs are retrieved immediately for transplantation. this study will use hearts from donors after circulatory death (dcd) donors. dcd donors are those whose hearts have stopped beating and no longer pump blood. dcd hearts are not used as often for transplantation today in the u.s. because they may be further injured during traditional cold storage. in the us, donor hearts are currently mostly obtained from donors after brain death (dbd), although dcd donors are used for other donated organs, such as: lungs, kidneys, and livers. this study will evaluate whether patients who receive a dcd heart transplant using either nrp or dpp have similar outcomes as patients who receive dbd hearts using standard cold storage. the study will also evaluate whether dcd procured hearts have a meaningful impact on hearts available for transplantation at our center. ten (10) dcd donor heart recipients will be enrolled into the study intervention group, and approximately 30 dbd donor heart recipients will be enrolled into the control group.

Eligibility criteria:
recipient inclusion criteria: 1. subjects must be willing and be capable of understanding the purpose and risks of the study and must sign a statement of informed consent or consent of a legally authorized representative of a cognitively impaired individual will be obtained before the cognitively impaired individual may be included in research. 2. signed: 1) written informed consent document and 2) authorization to use and disclose protected health information 3. male or female, aged 18 years of age or older listed for primary heart transplant recipient exclusion criteria: 1. prior history of cardiac transplantation 2. multi-organ transplant 3. current or planned participation in another interventional trial 4. recipient has any condition that, in the opinion of the investigator, would make study participation unsafe or would interfere with the objectives of the study
prediction models for risk score and prognosis of intraoperatively acquired pressure injury in surgical patients

Conditions: Pressure Ulcer; Predictive Models; Surgical Patient; Clinical Outcome

Summary: the study aims to effectively identify the risk of intraoperative acquired pressure injuries (iapi) in surgical patients through a prospective multicenter approach. it combines indicators from commonly used assessment tools and practical experience judgments to construct a comprehensive assessment framework. by incorporating various indicators, the study aims to improve the accuracy and reliability of identifying patients at risk of iapi during surgery. this will help clinicians in making informed decisions and implementing preventive measures to minimize the occurrence of pressure injuries. the multicenter approach ensures a diverse and representative sample of patients from different surgical settings. this increases the generalizability of the study findings and enhances the applicability of the assessment framework across various clinical settings. the project's methodology involves collecting data on patient demographics, medical history, surgical procedure details, and assessment tool scores. these data points will be analyzed to identify significant risk factors for iapi and develop a risk prediction model. the study also takes into consideration practical experience judgments, which acknowledge the importance of clinical expertise in assessing patients' risk of iapi. this ensures that the assessment framework is not solely reliant on assessment tools but also incorporates the insights of experienced clinicians. overall, this prospective multicenter study aims to contribute to the field by providing a comprehensive and practical approach to identify the risk of iapi in surgical patients. the findings from this study can be utilized in clinical practice to improve patient outcomes and reduce the incidence of pressure injuries during surgery.


Eligibility criteria:
inclusion criteria: all patients who underwent surgery procedure at the participating setting after the study registration. exclusion criteria: patients who have already been diagnosed with pressure injury (stage ii and above) before undergoing surgery procedure. patients/relatives/guardians understand the refusal of data to be used for clinically relevant research. investigators believe that certain patient conditions may affect the efficacy and safety assessment of this study.

Keywords: intraoperatively acquired pressure injury pressure ulcer predictive models surgical patient clinical outcome
observational post-authorisation study on the use of bemfola® in human assisted reproductive techniques in spain.

Conditions: Infertility

Summary: non-comparative, observational, ambispective post-authorisation study (epa-sp).


Eligibility criteria:
inclusion criteria: * women aged ≥ 18 years * currently undergoing an ivf or icsi cycle or are oocyte-donors * have completed controlled ovarian stimulation * have received at least 5 doses of bemfola® * are pituitary suppressed with a gnrh antagonist * have undergone oocyte retrieval * have signed the informed consent form exclusion criteria: * hypersensitivity to the active substance follitropin alfa, fsh or to any of the excipients listed * presence of tumours of the hypothalamus or pituitary gland

Keywords: bemfola r-hfsh art oocytes ohss pregnancy
clinical trial to evaluate the efficacy and safety of meditoxin® in subject with idiopathic overactive bladder

Conditions: Overactive Bladder

Summary: this study is for patients who have idiopathic overactive bladder symptoms. this study will evaluate efficacy and safety of neuronox® against placebo.


Eligibility criteria:
inclusion criteria: * male and female subjects aged above 20 * patient with overactive bladder symptoms lasting at least 6 months exclusion criteria: * patient with a history of surgery or a disease that may affect bladder function.
machine vision based mds-updrs iii machine rating

Conditions: Parkinsonian Disorders; Machine Learning

Summary: the movement disorders society (mds) unified parkinson's disease rating scale (updrs) part iii (mds-updrs iii) is the primary assessment method for motor symptoms in parkinson's disease patients. currently, movement disorder specialists conduct semi-quantitative scoring, which entails limitations such as subjectivity, weak sensitivity, and a limited number of professional physicians. this study, based on machine vision, establishes gold standard labels according to expert scoring. by using machine learning, we develop a machine rating model and compare the model's performance with gold standard rating and general clinical rating to investigate the accuracy of machine vision-based mds-updrs iii machine rating.


Eligibility criteria:
inclusion criteria: * meeting the diagnostic criteria for parkinsonism established by the international movement disorder society: having bradykinesia, and meeting at least one of the two criteria for resting tremor or muscle rigidity * 20 to 80 years old * good compliance, voluntarily joining the study, and able to sign an informed consent form or have it signed by a legal representative exclusion criteria: * significant cognitive impairment (mmse ≤ 23) * unable to sign written informed consent or unable to complete the trial due to other reasons * other situations in which the researcher deems the participant unsuitable for this study * participation in other clinical trials
efficacy and safety study of mci-186 for treatment of amyotrophic lateral sclerosis (als) who met severity classification iii

Conditions: Amyotrophic Lateral Sclerosis (ALS)

Summary: the primary objective of this study is to evaluate the efficacy of 60mg of mci-186 via intravenous drip once a day in patients with als whose severity is classified as grade iii, based on the changes in the revised als functional rating scale (alsfrs-r) scores after 24 weeks administration in double-blind, placebo-controlled manner. and in addition, this study will be performed to examine the safety of mci-186 to als patients who met severity classification iii.


Eligibility criteria:
inclusion criteria: * patients who are defined as "definite als," "probable als" or "probable-laboratory-supported als," met diagnostic criteria revised el escorial for airlie house. * patients who cannot take at least one action of eating a meal, excreting, or moving with oneself alone, and need assistance in everyday life. * patients whose progress of the condition during 12 weeks before administration meet other requirements. exclusion criteria: * patients judged to be inadequate to participate in this study by their physician, because those patients' general condition deteriorated to the point that they need to be hospitalized for severe hepatic disease, sever heart disease, sever renal disease and so on, or they need to be administered antibiotics to infection. * patients who complain the difficulty in breathing caused by deteriorating the respiratory function. * patients with such complications as parkinson's disease, schizophrenia, dementia, renal failure, or other severe complication, and patients who have the anamnesis of hypersensitivity to edaravone. * pregnant, lactating, and probably pregnant patients, and patients who want to become pregnant, and patients who can not agree to contraception. * patients who have been administered other investigational products within 12 weeks before consent, or who are participating in other clinical trials at present. * in addition to the above exclusion criteria, patients judged to be inadequate to participate in this study by their physician.

Keywords: amyotrophic lateral sclerosis free radical scavenger