Kornimate/medical-research-clean huggingface dataset:
reduced intensive idarubicin and cytarabine plus venetoclax as first-line treatment for adults aml and mds

Conditions: Acute Myeloid Leukemia; Myelodysplastic Syndromes

Summary: reduced intensive 3 + 5 idarubicin and cytarabine chemotherapy plus venetoclax as first-line treatment for adults with acute myeloid leukaemia and high-risk myelodysplastic syndrome

multiple clinical trials about chemotherapy plus venetoclax in primary diagnosed aml or relapsed/refractly aml were ongoing to attempt the facility of the combination. zu et al demostrated that full dose of 3 + 7 daunorubicin and cytarabine chemotherapy plus 8 days escalated venetoclax acheived 91% of cr/cri with 97% 1-year overall survival and 72% 1-year event-free survival. in this trial , we try to reduced the intensive of 3 + 5 idarubicin and cytarabine chemotherapy, but prolong venetoclax to two weeks in the induction therapy in adults aml/mds. we expect to increase the induced remission rate by extending the dosage of targeted drug venetoclax, and minimize the side effects by reducing the dose of 3 + 7 induction chemotherapy, so as to achieve the goal of high efficiency and low toxicity.

Eligibility criteria:
inclusion criteria: 1. aged 18-60 years 2. had a confirmed diagnosis of previously untreated de novo acute myeloid leukaemia or high risk myelodysplastic syndrome by bone marrow examination according to the criteria presented by who. 3. eastern cooperative oncology group performance status of 0-2. 4. adequate renal and hepatic function (appendix 2 p 45), and left ventricular ejection fraction of at least 45% by echocardiography. exclusion criteria: 1. younger than 18 years old, or older than 60 years old. 2. diagnosed as acute promyelocytic leukaemia. 3. pretreated with anthracycline. 4. cns involvement. 5. positive for hiv, hepatitis b virus, or hepatitis c virus. 6. new york heart association cardiovascular disability status higher than grade 2 (grade 2 is defined as cardiac disorder that is asymptomatic at rest, but ordinary physical activity might result in fatigue, palpitations, dyspnoea, or angina), chronic respiratory diseases requiring continuous supplementary oxygen, inability to take oral medication or malabsorption syndrome 7. uncontrollable systemic infection (viral, bacterial, or fungal), 8. inability to sign the informed consent form.
effect of oxytocin nasal inhalation on empathy analgesia

Conditions: Oxytocin; Pain; Empathy; Social Familiarity; Analgesia

Summary: this study recruited healthy volunteers and randomly divided them into four groups. they inhaled oxytocin or saline, and watched a pain test video with photos of acquaintances or strangers, respectively, to test whether their feelings of the same thermal pain stimulus had changed.


Eligibility criteria:
inclusion criteria: * healthy volunteers exclusion criteria: * during pregnancy; * have participated in any research related to pain; * sleep disorders; * used alcohol, caffeine, nicotine, or other psychoactive substances within 24 hours before the test; * experienced intense pain requiring medical analgesia within three months prior to the trial; * taking any medication, including over the counter medication; * addiction to alcohol, tobacco, or drugs; * a history of any respiratory, circulatory, neurological, musculoskeletal, and/or mental illness; * current symptoms of depression and/or anxiety. (see quantitative sensor testing for specific standards)
comparison of training in virtual environment with and without physiotherapeutic intervention in chronic stroke patients

Conditions: Stroke

Summary: the aim of this study is to compare the effects of balance training in a virtual environment with and without physiotherapeutic intervention on the motor function, balance and gait in chronic stroke patients. it is a prospective, single blinded, randomized clinical trial performed at center of research of the department of speech therapy, physical therapy and occupational therapy of são paulo university. forty patients will be randomly assigned in control and experimental group.

the aim of this study is to compare the effects of a balance training program in a virtual environment (using a gaming system with balance board device) with and without verbal/manual physiotherapeutic intervention, on the motor function, balance and gait in chronic stroke patients. it is a prospective, single blinded, randomized clinical trial, performed at center of research of the department of speech therapy, physical therapy and occupational therapy of são paulo university. forty chronic stroke patients will be randomly in control and experimental group, 20 each one. both groups conduct 14 training sessions, twice a week, for seven weeks. each session will consist a 30 minute-global-exercise series including stretching, muscle strength and axial mobility exercises. after this, both groups will perform more 30 minutes of balance training using eight wii fit games which stimulate motor and cognitive functions. the main outcome measures will be: the lower limb subscale of the fugl-meyer assessment (fma-le); balance evaluation systems test (bestest) and 6- minute walk test (6mwt).

Eligibility criteria:
inclusion criteria: * hemiparetic status resulting from a single stroke at least 6 months earlier; * the ability to walk 10 m independently with or without an assistive device; * a montreal cognitive assessment (moca) score of ≥ 20; * the absence of a musculoskeletal condition that could potentially affect the ability to stand or walk safely; * the absence of serious visual impairment or a hearing disorder; * muscle strength ≥ 3 in lower limbs; * ability to understand and follow simple instructions. exclusion criteria: * severe dementia or aphasia; * hemispatial neglect, ataxia or any other cerebellar symptom; * inability to stand without minimal assist; * uncontrollable medical complications * participation in other studies or rehabilitation programs

Keywords: stroke postural balance motor function gait virtual reality exposure therapy physiotherapist
measuring symptom relief after radiofrequency ablation of the thyroid

Conditions: Thyroid

Summary: the purpose of this study is to measure the impact of thyroid radiofrequency ablation procedure on patients with thyroid-related symptoms using a modified pre-existing scoring system.


Eligibility criteria:
inclusion criteria: - undergoing radiofrequency ablation (rfa) for symptomatic thyroid nodule(s). exclusion criteria: - decline to participate in research.

Keywords: thyroid radiofrequency ablation procedure
shoulder symptom irritability scale: a single-blinded observational study

Conditions: Shoulder Pain; Pain

Summary: the purpose of this study is to examine the reliability and use of the shoulder symptom irritability classification system for the purposes of determining an appropriate treatment intensity to better help people with shoulder pain.

background physical therapists regularly make decisions regarding intervention intensity based upon pathoanatomy, symptom irritability, and impairment identification, but the reliability and validity of classifying patients by symptom irritability is unknown. purpose examine the reliability and use of the shoulder symptom irritability classification system for the purposes of determining an appropriate treatment intensity. design prospective repeated-measures single-blinded design to determine reliability and a cross-sectional design will be utilized to aid in determining construct validity. methods twenty-five (25) raters will be trained to make paired ratings in 90 subjects with primary complaints of shoulder pain. raters will record the shoulder symptom irritability level and also select the appropriate intervention intensities for the subjects. raters will also be asked to choose anticipated interventions for subjects. data analysis prevalence-adjusted, bias-adjusted kappa for ordinal scales (pabak-os) will be the primary measure of reliability. dependent upon the distribution of the data, other forms of kappa may be utilized to analyze the data most appropriately. to determine differences in reliability between groups with and without clinical specialization, an independent t test will be utilized with α = 0.05. lastly, analysis of variance with post-hoc analysis will be used to compare functional disability across different levels of irritability. significance this study addresses key gaps in the understanding of symptom irritability and how it relates to clinical decision making. it is expected that symptom irritability should logically drive intervention selection and intensity of rehabilitation interventions.

Eligibility criteria:
rater group inclusion criteria: * state licensure as a physical therapist and regular clinical practice with patients with shoulder disorders, defined as a minimum of 500 clinical hours per year in an orthopaedic setting with \>10% of patients with shoulder disorders exclusion criteria: * not meeting inclusion criteria patient group inclusion criteria: * presenting with a chief complaint of shoulder pain, not extending to the neck, for outpatient physical therapy consultation exclusion criteria: * illiteracy in english and age less than 18 years. additionally, subjects will be excluded from the study if they present with pain or symptoms distal to elbow, have had shoulder surgery on the symptomatic side in the past year, if active or passive cervical spine rom reproduces shoulder pain, have a positive spurling's test, or if they are unable to complete the patient reported functional questionnaires

Keywords: reliability validity classification irritability symptom intensity intervention
comprehensive behavioral (comb) model of treatment for trichotillomania

Conditions: Trichotillomania

Summary: this study will be the first randomized controlled trial of comprehensive behavior modification (comb) as a treatment of trichotillomania (ttm). comb treatment (12 weekly sessions, following a manual developed in an earlier treatment development project) will be compared to minimal attention control among adults (n = 42) with ttm.

treatment based on the comb model has been influential in the field of body-focused repetitive behaviors (bfrb's), but there is limited empirical research on its efficacy. our first project (falkenstein et al., 2016) developed a 12-session manual for comb and a method for evaluating therapist adherence to the model that can be used reliably and provided encouraging (uncontrolled) data on the effects of comb through 3-month follow-up. the proposed project extends the earlier work in two main ways: (a) using random assignment to comb vs. comparison condition to test whether comb works better than the passage of time + demand characteristics of being in a ttm study alone; and (b) gathering initial evidence on how comb works. treatment will be conducted at two sites -- washington, dc (american university and the behavior therapy center of greater washington) and chicago (university of chicago). participants in the minimal attention control condition will receive comb therapy after the post-treatment \[week 12\] assessment is conducted. uncontrolled follow-up data will be collected through 3 (mac condition) or 6 (immediate comb condition) months after the end of comb treatment.

Eligibility criteria:
inclusion criteria: * 18 years of age or older * diagnosed with trichotillomania * medication type and dosage \[if any\] stable for at least 3 months exclusion criteria: * active suicidality --probable bipolar disorder * probable psychosis * other pressing clinical problem requiring immediate treatment * current psychotherapy and unable/unwilling to discontinue
neo-adjuvant chemotherapy evluation in gastric cancer patients based on circulating exosomal lncrna-gc1

Conditions: Gastric Cancer; Chemotherapy Effect

Summary: the investigators hope that through the analysis and research to find determine whether lncrna-gc1 could serve as a non-invasive biomarker for monitoring the neo-adjuvant chemotherapy response for personalized medicine for gastric cancer.

the lncrna-gc1could noninvasively track dynamics of tumor burden and has been proposed as a real-time biomarker that can provide both predictive and prognostic values. but the value in monitoring the neo-adjuvant chemotherapy response is unclear. the investigators hope that through the analysis and research to find determine whether lncrna-gc1 could serve as a monitoring biomarker for patients with gastric cancer receiving neo-adjuvant chemotherapy.

Eligibility criteria:
inclusion criteria: * having signed informed consent * age≥ 18 years old * histologically confirmed gastric adenocarcinoma * radiographically identified as advanced gastric cancer exclusion criteria: * other previous malignancy within 5 year * surgery (excluding diagnostic biopsy) within 4 weeks prior to study * pregnancy or lactation period * legal incapacity

Keywords: circulating exosomal lncrna-gc1 advanced gastric carcinoma treatment response
safety and pilot efficacy of akb-9778 in subjects with diabetic macular edema

Conditions: Diabetic Macular Edema (DME)

Summary: the purpose of this study is to evaluate the safety, pharmacokinetics, pharmacodynamics, and pilot efficacy of multiple ascending dose levels of akb-9778 given as subcutaneous injections daily for 28 days in patients with diabetic macular edema (dme).


Eligibility criteria:
inclusion criteria: the following is an abbreviated list of inclusion criteria: * adults between 18 to 80 years of age, inclusive * diagnosis of diabetes mellitus (type 1 or type 2) * decrease in vision determined to be primarily the result of dme in the study eye * definite retinal thickening due to diffuse dme involving the center of the macula in the study eye * mean central subfield thickness of at least 325 µm by oct in the study eye * early treatment diabetic retinopathy study (etdrs) letter score bcva ≤ 70 (20/40) in the study eye exclusion criteria: the following is an abbreviated list of exclusion criteria: * hemoglobin a1c (hba1c) ≥ 11.5% * history of any of the following in the study eye (however, the following are not exclusionary in the fellow eye): 1. panretinal scatter photocoagulation (prp) or focal laser within 12 weeks prior to screening 2. prior pars plana vitrectomy within 12 weeks prior to screening 3. any ocular surgery within 12 weeks prior to screening 4. yag capsulotomy within 7 days prior to screening 5. prior intravitreal, subtenon, or periocular steroid therapy within 3 months prior to screening or prior treatment with intravitreal anti-vegf treatment within 1 month of screening
reflectance confocal microscopy of oral cancers in vivo: a preliminary trial comparing intra-oral imaging with pathology

Conditions: Head and Neck Cancer; Squamous Cell Carcinoma (SCC) of the Oral Cavity

Summary: the purpose of this study is to get images (pictures) of oral lesions, which occur inside the mouth, before the patient's surgery using a special camera. these pictures will be used in our research to evaluate a new technology that uses a laser and takes pictures of the microscopic structure of tissue. the technology is called "reflectance confocal microscopy." we would like to compare what the camera sees to biopsies (pathology) of the same area. we will evaluate the pictures obtained from the patient to determine whether this technology may be useful in the future. we hope this technology can be used as a tool for early diagnosis of oral cancers and for guiding surgery.


Eligibility criteria:
inclusion criteria: * patients with biopsy-proven oral scc who are scheduled to undergo surgery in the msk head and neck service. * ability to sign informed consent. * age ≥ 18 years. exclusion criteria: * cancer located on a site that may not be convenient or accessible for imaging with the current version of the rcm device (gingivobuccal region, back of the oral cavity, back of the tongue, floor of the mouth, deep under the tongue, etc.). * inability to give informed consent.

Keywords: reflectance confocal microscopy 15-128
oral colostrum and its effect on immune system

Conditions: Immune System Diseases; Premature Infant Disease; Immunoglobulin Deficiency

Summary: the purpose of this project is to increase the serum immunological defenses of premature infants less then 32 weeks of gestation by administrating colostrum in the oropharyngeal mucosa versus placebo

prematurity is a public health problem because premature newborns have an immature immune system. breast milk (colostrum) contains bioactive components that provide antimicrobial, anti-inflammatory, antioxidant, and immunomodulatory functions. these bioactive components are in higher concentrations in mothers' colostrum of premature babies. because of the morbidities presented by premature infants, they remain fasting and lack the potential benefit provided by colostrum. when the colostrum is placed in the oropharyngeal mucosa, the immunocompetent cells stimulate the immune system, increasing the serum concentrations of immunoglobulins. objectives: to determine the efficacy of early administration of colostrum in the oropharyngeal mucosa in preterm infants less than 32 weeks of gestation and its effect on the immune system by quantifying immunoglobulins in preterm infants born at the national institute of perinatology. . methods / design: 1 year, double blind randomized controlled clinical trial. the newborns included will be randomly assigned to one of the 2 groups: group 1:, newborns receiving colostrum 0.3 ml every 4 hours in the oropharyngeal mucosa, for 3 days. newborns from block b will receive orally sterile water (placebo) 0.3 ml following the same protocol. serum immunoglobulin a, m and g concentrations will be determined before the start of the study on day 0 of life and after 7 and 28 days of life. they will continue in time until 36 sdg or at discharge, whichever comes first.

Eligibility criteria:
inclusion criteria: * newborn 32 gestational weeks * hospitalized in neonatal intensive care unit * agreement signed by the legal representative exclusion criteria: * intraventricular haemorrhage ii/iv grade * congenital sepsis (early sepsis) * congenital malformations * early transfusions

Keywords: immunoglobulins a, g and m neonatal sepsis human milk orally colostrum
comparative study of postprocessing imaging systems for diminutive colonic polyps

Conditions: Diminutive Colon Polyp; Adenomatous Polyp; Hyperplastic Polyp; Colonoscopy

Summary: several novel imaging technologies are currently used for detection and differentiation of colonic polyps during colonoscopy, such as nbi (olympus), fice (fujinon), and i-scan (pentax). several previous studies have indicated that nbi without magnification can be useful for real-time differentiation of diminutive colonic neoplasias. to date, however, there are no studies comparing nbi with other imaging systems (fice or i-scan) for differentiation of diminutive colonic polyps. the study objectives are to compare the diagnostic efficacy of nbi with that of i-scan in real-time prediction of diminutive colonic polyps. in this prospective pilot study, diminutive colonic polyps detected during colonoscopy will be observed with conventional colonoscopy, thereafter will be observed with new imaging systems. sensitivity, specificity, and diagnostic accuracy of both nbi and i-scan will be assessed by reference to histological results obtained by endoscopic biopsy or polypectomy.


Eligibility criteria:
inclusion criteria: * screening or surveillance colonoscopy * age over 18 * informed consent exclusion criteria: * history of inflammatory bowel diseases * history of hereditary colorectal cancers and polyposis syndrome * inability to give informed consent * use of antiplatelet agent and anticoagulants * pregnancy
sleep in critically ill patients on mechanical ventilation in icu

Conditions: Polysomnographic Sleep Characteristics

Summary: 15 patients with sepsis, 15 patients with copd and 15 surgical patients will undergo polysomnographic sleep monitoring up to 24 hours in order to define if there are common sleep features within the groups

it is an observational study in order to define if there are common polysomnographic sleep features within the following three groups of wake critically ill patients on mechanical ventilation in icu: the group of septical patients, the group of patients with chronic obstructive pulmonary disease in exacerbation and the group of surgical patients without sepsis. 15 patients will be included in each group. they will undergo polysomnographic sleep monitoring during up to 24 hours. polysomnograms will be studies then in order to find out if there are common sleep characteristics within the homogeneous patient groups of critically ill.

Eligibility criteria:
inclusion criteria: * wake non-sedated patients * mechanical ventilation exclusion criteria: * age \< 18 years * pregnant * glasgow coma scale \< 11 * sedated patients
tomosynthesis in screening mammography

Conditions: Breast Density >25%

Summary: tomosynthesis is a new digital mammographic tool which can be performed at the same time as routine screening mammography. it creates ct-like slices through the breast, minimizing the tissue overlap. tomosynthesis has the potential to improve screening mammography outcomes by increasing cancer detection rates, decreasing false negative rates and false positive rates. this trial will help determine if tomosynthesis is useful in a screening setting.

we will evaluate the effect of tomosynthesis mammography outcomes in a screening setting. we will collect data on interpretation time, recall rates, cancer detection rates, and interval cancer rates in dense breasts(≥ 50% glandular density). if the interpretation time is less than 4x a routine read, and the recall rates have dropped \< 30% of initial values, we will then conduct a study with larger numbers to better evaluate cancer detection rates and interval cancer rates.

Eligibility criteria:
inclusion criteria: * females 40-69 years of age attending screen test kingsway referred for a screening mammogram as defined by canadian cancer society guidelines. * prior mammogram report indicating ≥ 25% breast density. exclusion criteria: * prior mammogram report indicating \<25% breast density. * breast implants * pregnancy

Keywords: tomography mammography breast neoplasms prevention and control