Kornimate/medical-research-clean huggingface dataset:
use of loop recorders for diagnosis of palpitations in a&e

Conditions: Palpitations

Summary: heart rhythm abnormalities underlie one of the common presenting complaints to the a\&e and out-patient departments, specifically awareness of heart beats or palpitations. unless an ecg (electrocardiogram) tracing of the heart rhythm can be recorded while the patient is having symptoms, it is very difficult to determine the cause of the palpitations. the conventional approach is to refer these patients from the emergency departments to the cardiology outpatients where they undergo repeated short term rhythm monitoring hoping to record the rhythm underlying the patient's complaint. unfortunately, this often yields no results thus delaying definitive treatment and incurring extra costs of repeated investigations and a\&e presentations. this study aims to compare the ability of the conventional approach to establish a definite diagnosis compared to that of an early invasive monitoring approach with a small implantable device that records the heart rhythm at all time for up to 18 months.


Eligibility criteria:
inclusion criteria: * age 18 years or older * good history of episodic symptomatic sustained palpitations (sudden onset and offset, fast heart beats, may be associated with shortness of breath or dizziness) * terminates before presentation to hospital * episodes occur at a frequency of less than once every two weeks * never previously caught on ecg or ambulatory monitoring * normal resting ecg exclusion criteria: * contraindication to ilr implantation i.e. ongoing oral anticoagulation with inr \>1.6, ongoing infection, sepsis or fever, etc. * palpitations suggestive of extrasystoles (single missed or dropped beats) * known or suspected severe valvular or myocardial heart disease * an audible heart murmur * any abnormality on the surface ecg * thyrotoxicosis * patients who refuse an ilr when offered will not be included in either limb of the study
effects of a liquid meal and gut hormones (gip and glp-2) on bone remodeling in participants with hypoparathyroidism.

Conditions: Hypoparathyroidism

Summary: hypoparathyroidism (hypopt) is characterized by low levels of pth. in this study we will test the effects of a liquid meal on the bone remodeling in participants with hypoparathyroidism. furthermore, we will test the effects of the gut hormones gip and glp-2.


Eligibility criteria:
inclusion criteria: * age between 18 and 76 * hypoparathyroidism exclusion criteria: * diabetes * disease in the gastrointestinal tract * antiosteoporotic drug * long term steroid treatment (within the last 12 months) * pregnancy

Keywords: hypoparathyroidism glucose-dependent insulinotropic polypeptide (gip) glucagon-like peptide-2 (glp-2) bone remodeling bone resorption bone formation c-terminal telopeptide (ctx) n-terminal propeptide of type 1 procollagen (p1np)
aberrant helix pomatia agglutinin binding glycan expression in follicular thyroid tumours

Conditions: Follicular Thyroid Cancer

Summary: aberration of glycosylation is a hallmark of cancer cells, and plays an important role in oncogenesis and cancer progression, including metastasis. one of the markers of aberrant glycosylation (o-linked) is the binding of the lectin helix pomatia agglutinin (hpa), which has been demonstrated in a wide range of human cancers, especially in tumours with a more aggressive phenotype. data on the role of hpa within follicular neoplasms of the thyroid gland are currently lacking, therefore we sought to investigate possible changes in cell surface glycosylation associated with this type of neoplasms.

lectin-histochemistry was performed on 37 archival paraffin wax-embedded specimens of various follicular thyroid tumours (10 follicular adenomas (fa), 10 minimally invasive follicular carcinomas (miftc), 13 widely invasive follicular cancers (wiftc) and 4 metastatic follicular thyroid cancers (metftc)). sections were scored as positive when ≥5% of cancer cells labelled positive, and scored as negative when \<5% labelled positive for hpa binding. assessments of hpa-binding were performed by two observers, who were blinded to the identity of the sample, and their results were compared.

Eligibility criteria:
inclusion criteria: * for this retrospective cohort study, 37 patients who underwent thyroid surgery for a thyroid follicular neoplasm between 2005 and 2018 were identified from our institutional database and their tumours, characteristics and outcomes were analysed. exclusion criteria: * n/a

Keywords: glycosylation
verification of kimmerle's anomaly by x-ray methods of research

Conditions: Kimmerle's Anomaly

Summary: kimmerle's anomaly is a bony bridge over the posterior arch of the first cervical vertebra that forms a bony ring. the vertebral artery passes through the opening. this bone bridge could theoretically be an extravasal compression of the artery and disrupt the normal blood flow to the brain. evaluating the data of x-ray methods, determine the frequency of occurrence and types of kimmerle anomaly.

it is planned to conduct an examination of 30 patients on the basis of the department of radiation diagnostics and therapy of the samarkand state medical institute. patients of all ages will be examined, directed by doctors for computed tomography of the brain with the capture of the upper cervical spine and the cervical spine. with complaints of headache, dizziness, pain in the cervical region among those who have passed the study, it is necessary to identify patients with kimmerle's anomaly and determine the age at which it often occurs, whether it is a congenital pathology or the result of degenerative-dystrophic changes. it is also planned to calculate the frequency of occurrence among the population, the type of this pathology (complete and incomplete bone bridge, right-sided and left-sided location), the size of the hole formed. the condition of the posterior parts of the brain will be assessed in the presence of kimmerle's anomaly on a ct scan.

Eligibility criteria:
inclusion criteria: * patients with kimmerle's anomaly exclusion criteria: * patients in whom the structure of the first cervical vertebra is not clearly visible
focusing on the maryam's flower during the birth

Conditions: Labor Pain

Summary: to determine the effect of focusing on the virgin mary flower during the birth process on labor pain, labor duration and perceived fatigue in birth. method: the study will be completed in a randomized controlled manner with a total of 126 primiparous pregnant women, 63 in the experimental group and 63 in the control group. pregnant women in the experimental group will focus on the virgin mary flower in the water-filled jar and imagine that their uterus and birth path are opening like the branches of the virgin mary flower that blooms as labor pains come. there will be no intervention in the control group other than routine midwifery care. research data will be collected with the pregnant introduction and birth process follow-up form, visual analog scale, and visual similarity scale for fatigue.

design and settings: this randomized controlled experimental study will conducted in the delivery room of the, turkey between the dates of november 2023 and april 2024

Eligibility criteria:
inclusion criteria: * being 18 years or older, * being in 37-42 weeks of pregnancy, * being primiparous, * having a single healthy fetus, * cervical dilatation not more than 3 cm.the one which, * in the first stage of labor, * does not have any complications preventing vaginal birth, * volunteer women who do not have disabilities in communication and perception exclusion criteria: * maternal and fetal complications * pregnant with assisted reproductive techniques, * having a presentation anomaly, * having a twin pregnancy, * electing cesarean section, * women whose cervical dilatation exceeds 3 cm and who are not willing to participate in the study
chronic lymphocytic leukemia registry study - multicenter prospective national study

Conditions: Chronic Lymphocytic Leukemia; Del(17P)

Summary: a prospective, multicenter national observational study for patients diagnosed as chronic lymphocytic leukemia across 25 centers in turkey

the purpose of this study is to explore the history and real world management of patients diagnosed with cll, provide insight into the management of cll, and evaluate the effectiveness of first, second and subsequent therapeutic strategies employed in both the community and academic settings.

Eligibility criteria:
inclusion criteria: * patients diagnosed as cll * 18 years or older * able and willing to provide the written informed consent exclusion criteria: * younger than 18 years

Keywords: cll, del(17p)
the role of renal progenitors and polyploid tubular cell response in glomerular and tubular diseases

Conditions: Nephropathy

Summary: renal progenitors are a subset of parietal epithelial cells (pecs) localized at the urinary pole of bowman's capsule. experimental models of podocyte damage showed that pecs can potentially regenerate lost podocytes by migrating from bowman's capsule to the glomerular tuft, acquiring the morphological and functional features of mature podocytes. podocyte loss and damage, as well as the inability of pecs to replace lost podocytes, lead to glomerular scarring and chronic kidney disease (ckd) progression. in addition, the investigators of the present study and others have recently demonstrated the existence of a specific subpopulation of tubular cells in the human kidney with a high potential for regeneration and resistance to death, thus acting as tubular progenitors. these cells are involved in tubular response to damage during acute kidney injury (aki) trough endoreplication (polyploidization). kidney biopsy is the cornerstone of diagnosis in many kidney diseases leading to ckd and aki, allowing unambiguous diagnosis in some cases and presumptive diagnosis of ongoing disease in others. very recently, super resolution imaging techniques proved to maintain current diagnostic standards while allowing to study morphological features of pathophysiological mechanisms of glomerular and tubular diseases. the rationale of this project is to study the role of renal progenitors (pecs and tubular progenitors) in the pathogenesis of ckd and aki trough super resolution imaging applied to human renal biopsies, to the aim of identifying relevant connections with clinical data and markers of damage and/or disease progression.


Eligibility criteria:
inclusion criteria: * patients with glomerular diseases undergoing renal biopsy (e.g., rapidly progressive glomerulonephritis, minimal change disease, focal segmental glomerulosclerosis, diabetic nephropathy, lupus nephritis, membranous nephropathy, iga nephropathy, etc) * patients with aki, regardless of the nature of the damage (septal, ischemic, toxic, or unknown). * signed informed consent form exclusion criteria: * sample insufficient and/or unavailable
evaluation of response to the neoadjuvant chemotherapy for advanced ovarian cancer by multimodal functional imaging

Conditions: Ovarian Cancer

Summary: this study evaluates the therapeutic response by modern fmri and pet techniques with the perspective to exploit multimodal data (fusion mri/pet). the sponsor would like to optimize the respective performances and to define the early assessment criteria, at the first detox, of the treatment efficacy, with and without antiangiogenic agent.

this study evaluates the therapeutic response by modern fmri and pet techniques with the perspective to exploit multimodal data (fusion mri/pet). the sponsor would like to optimize the respective performances and to define the early assessment criteria, at the first detox, of the treatment efficacy, with and without antiangiogenic agent. it is a single center evaluation of the study treatment.

Eligibility criteria:
inclusion criteria: * epithelial ovarian carcinoma, fallopian tube, or primary peritoneal carcinoma figo iiic-iv histologically confirmed by biopsy and documented stage and untreated * pre-treatment abdominopelvic pet-ct and mri within 4 weeks before neoadjuvant chemotherapy. * during laparoscopy performed by an experienced surgeon in the treatment of ovarian cancer, patient considered ineligible for tumor cell kill at the outset. * a life expectancy of greater than three months * an eligible patient for paclitaxel and carboplatine based chemotherapy. * membership of a social security scheme * patient information and signed, dated written informed consent exclusion criteria: * pre-treated using chemotherapy, radiology, or surgery for an ovarian cancer. * contraindication to mri with the injection of contrast product, i.e, the first three months pregnancy, claustrophobia, major allergic antecedents, pacemaker, some surgery clips, some heart valves, cava filter, implanter pumps, cochlear implants, metallic extraneous malter. * uncontrolled diabetes * pregnancy and nursing * other uncontrolled medical conditions as thyroid pathology, neuropsychiatric disease, infection, coronary insufficiency or grade 3 - 4 heart disease established by association "new york heart" * patient deprived of liberty and legally protect adult, or not in position to give consent.
efficacy of bisphosphonates in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (sapho) syndrome

Conditions: SAPHO Syndrome

Summary: this study is designed to evaluate long term efficacy of intravenous bisphosphonates for bone marrow edema in patients with sapho syndrome.

the study will evaluate the long term efficacy at 3 days, 3 and 6 months after pamidronate disodium administered. patients will be administered pamidronate disodium 1 mg/kg, iv, qd, for 3 days, and every 3 months (up to month 6).

Eligibility criteria:
inclusion criteria: 1. male and female patients between the ages of 18 and 70 years 2. only 1 of the 4 inclusion criteria is sufficient to arrive at a diagnosis of sapho syndrome： * osteo-articular manifestations of acne conglobata, acne fulminans, or hidradenitis suppurativa * osteo-articular manifestations of ppp * hyperostosis (of the anterior chest wall, limbs or spine) with or without dermatosis * crmo involving the axial or peripheral skeleton with or without dermatosis palmoplantar pustulosis(ppp); chronic recurrent multifocal osteomyelitis(crmo) 3. mri shows bone marrow edema in affected site in patients 4. blood serum of patients show the normal white blood cell count, liver and renal function 5. patients who like to be followed up for 1 years 6. other protocol defined inclusion criteria may apply exclusion criteria: 1. women in pregnancy or lactation. 2. septic osteomyelitis 3. infectious chest wall arthritis 4. infections ppp 5. palmo-plantar keratodermia 6. dish except for fortuitous association 7. osteoarticular manifestations of retinoid therapy 8. other protocol defined exclusion criteria may apply

Keywords: treatment bisphosphonates response rate
surfactant replacement guided by early lung ultrasound score in preterm newborns with respiratory distress syndrome

Conditions: Preterm Birth

Summary: lung immaturity is a major issue in neonatal unit.the surfactant administration improves the pulmonary prognosis in premature infants with hyaline membrane disease who escape continuous positive airway pressure (cpap). this surfactant had been administered at 5h25min of life in saint etienne from 2016 to 2019. studies suggest that the earlier the surfactant is administered, the more it can reduce the rate of bronchodysplasia and mortality. and some studies show a pulmonary ultrasound could help to administrate the surfactant earlier this is why a new faster strategy for diagnosing preterms needing surfactant will be usefulness and have been done in saint-etienne since 2021 thanks to a ultrasound score (lus).

this current study analyzes the impact of early lungs ultrasounds which use a semi-quantitative assessment : the lung ultrasound score (lus), in preterms \<33 weeks on the time to surfactant administration. the current hypothesis is that lung ultrasound can increase the number of preterms with surfactant replacement within the first 3 hours of life. this is a prospective, comparative, observational trial between two different cohorts : the last 6 months of 2019 (without score lus) versus the first 6 months of 2021 (with score lus).

Eligibility criteria:
inclusion criteria: * newborns \<33 weeks old * born at the saint etienne university hospital * respiratory distress syndrome exclusion criteria: * chromosomal abnormality, * multi-polymalformations syndrome, * congenital pulmonary disease, * septic shock, * congenital lung infection, * meconium inhalation, * pneumothorax * conditions requiring surgery in the first week of life.

Keywords: preterm lung ultrasound score surfactant
autogenic inhibition versus reciprocal inhibition muscle energy techniques in iliotibial band syndrome

Conditions: Iliotibial Band Syndrome

Summary: comparison of effects of autogenic inhibition and reciprocal inhibition muscle energy techniques on iliotibial band syndrome

a single-blinded randomized control trial will be conducted over a period of one year in foundation university islamabad. forty participants will be assigned to two groups: group a (ai) and group b (ri), with 20 participants each. the ai technique will involve a maximal isometric contraction of the target muscle followed by a stretch, while the ri technique will involve a maximal isometric contraction of the antagonist muscle followed by a similar stretching protocol. both groups will perform the exercises 3 times per week for 2 weeks. pain, hip range of motion (rom) and lower extremity function will be assessed using numeric pain rating scale (nprs), goniometer and lower extremity functional scale (lefs) respectively. the outcomes will be measured in terms of improvements in pain score (nprs), hip range of motion (rom), and overall lower extremity function.

Eligibility criteria:
inclusion criteria * both male and female participants * age : 19-45years (8) * lateral knee pain (\>3 months) * tenderness over lateral femoral condyle * positive flexibility tests * modified ober's test (9) * length assessment of tensor fasciae latae and iliotibial band (10) * positive pain provocation tests * renne's test * noble's compression test (11) \*(individuals with 3 positive tests out of above mentioned 4 tests will be included) exclusion criteria * recent lower limb or pelvic girdle surgery within the past 3 months * lower limb fractures or trauma within the past year. * multiple lower limb surgeries (\>2) * presence of any structural or postural disorders (kyphosis or severe scoliosis) * neurological disorders * hip and knee osteoarthritis * rheumatoid arthritis * pregnancy
real-world study to assess subcutaneous epcoritamab in adult participants with diffuse large b-cell and follicular lymphoma

Conditions: Diffuse Large B-cell Lymphoma; Follicular Lymphoma

Summary: diffuse large b-cell lymphoma (dlbcl) is an aggressive and rare cancer of a type of immune cells (a white blood cell responsible for fighting infections) and the most common type of non-hodgkin lymphoma. follicular lymphoma (fl) is a slow-growing type of non-hodgkin lymphoma. the purpose of this study is to assess the real-world effectiveness of subcutaneous epcoritamab in adult participants with advanced dlbcl and fl. epcoritamab is an investigational drug being developed for treating participants with dlbcl and fl. approximately 700 participants will be enrolled in approximately 80 sites across 12-20 countries globally. participants will receive epcoritamab as prescribed by their physician in accordance with local country label. participants will be followed for up to 3 years. there is expected to be no additional burden for participants in this trial. participants will attend regular visits during the study at a hospital or clinic according to their routine clinical practice.


Eligibility criteria:
inclusion criteria: * participants who are scheduled to be treated with epcoritamab for treatment after two or more prior lines of therapy 3l+ diffuse large b-cell lymphoma ((d)lbcl) or 3l+ follicular lymphoma (fl). * treatment with epcoritamab should be administered in accordance with the approved local label in the participating country. * the decision to treat the participant should have been made by the clinician prior to, and independently of any decision to approach the participant to participate in this study. exclusion criteria: * any condition included in the contraindications section of the approved local epcoritamab label in the participating country. * participation in a concurrent interventional clinical trial (not including non-interventional/ observational study, pmos, or registry participation) from enrollment and throughout the study.

Keywords: diffuse large b-cell lymphoma follicular lymphoma epcoritamab
robots for stroke survivors

Conditions: Stroke

Summary: the investigators are looking for individuals who have suffered a stroke to participate in an experiment examining the use of robotics in rehabilitation. they are trying to develop a robotic environment for hands after having had a stroke. participants will interact with up to two small robots and a visual display. the experiment involves minimal risk and may involve testing sessions over multiple weeks. subjects must be at least 1 year post-stroke and have difficulty picking up small objects. for more information, contact: bambi brewer, cmu ph.d. student, 412-241-9423 or bambi@andrew.cmu.edu.


Eligibility criteria:
inclusion criteria: * at least 1 year post-stroke * difficulty picking up small objects
propofol and magnesium sulfate intravenous infusion during endoscopic sinus surgery

Conditions: Endoscopic Sinus Surgery

Summary: endoscopic sinus surgery usually associated by bleeding, despite using of local vasopressor injection, head up position- controlled hypotension is generally used for control of this purpose. propofol has been reported as a good agent for controlled hypotension by decreasing systemic vascular resistance secondary to arterial and venous vasodilation and a decrease in myocardial contractility with a dose-dependent property. magnesium sulfate also has been reported as an agent of hypotensive anaesthesia by inhibition of the release of norepinephrine by blocking n-type calcium channel at the nerve ending beside acting as a vasodilator. the well known pharmacodynamic effects of the intravenous infusion of propofol or magnesium sulfate may prove the advantage of this group in controlling intraoperative blood pressure thus reducing surgical field bleeding.

the aim of the work to compare the efficacy of propofol and magnesium sulfate to control blood pressure during endoscopic sinus surgery and the resultant effects on the quality of the surgical field including bleeding and visibility.

Eligibility criteria:
inclusion criteria: * american society of anesthesiologists physical classes i or ii exclusion criteria: * patients refusal * patients with hypersensitivity for any drug used in the study including magnesium, propofol or isoflurane * patients receiving magnesium sulfate supplementation * patients receiving drugs known to have significant interaction. * patients with ischemic heart disease * patients with heart defects * patients with significant heart failure * patients with increased intracranial pressure. * patients with systemic hypertension