Kornimate/medical-research-clean huggingface dataset:
customization of cardiac readaptation based on force-velocity profile and heart rate variability

Conditions: Acute Coronary Syndrome

Summary: cardiac readaptation aims to mitigate cardiovascular risks and enhance the quality of life among coronary patients. our research laboratory has an international expertise in training optimization in top-athletes and a previous study has demonstrated the efficacy of optimizing cardiac rehabilitation through the power-force-velocity profile (pfvp). the findings exhibited significant improvements in aerobic capacity, muscular strength, and cardiovascular parameters among patients who were trained based on their pfvp. guided training utilizing heart rate variability (hrv) is also garnering increasing interest as a means to optimize training load and promote recovery

our study aims to evaluate the application of hrv in regulating training load based on fatigue levels in cardiac rehabilitation patients utilizing the pfvp framework.

Eligibility criteria:
inclusion criteria: * \>18 * acute coronary syndrome treated in the last 6 months * medical revascularization (angioplasty ± stenting) or surgical (coronary artery bypass) * initial cpett: mpa ≥ 60w in women and ≥80w in men * french * informed consent exclusion criteria: - significant co-morbidities limited practice of physical activity

Keywords: cardiac rehabilitation physical activity force-velocity profile autonomic nervous system coronary artery disease
study in patients with untreated multiple myeloma and renal insufficiency

Conditions: Multiple Myeloma; Renal Insufficiency

Summary: the study will evaluate the effects of bhq880 in patients with previously untreated multiple myeloma and renal insufficiency who are not considered candidates for bisphosphonate therapy. the primary objective of the study will be to evaluate the effect of bhq880 in combination with bortezomib and dexamethasone, compared to placebo administered with the combination on the time to first skeletal related event (sre) on study.


Eligibility criteria:
inclusion criteria: 1. confirmed diagnosis of multiple myeloma 2. life expectancy of more than 6 months in the absence of intervention 3. must not have received previous or be receiving current antimyeloma therapies 4. renal insufficiency 5. recovered from the effects of any prior surgery or radiotherapy exclusion criteria: 1. prior iv bisphosphonate therapy at any time or oral bisphosphonate therapy within 4 months of study entry 2. paget's disease of bone or uncorrected hyperparathyroidism 3. impaired cardiac function 4. known hiv, known active hepatitis b, or known or suspected hepatitis c infection 5. pregnant or nursing (lactating) women, 6. women of child-bearing potential, unless agreeable to using 2 birth control methods other protocol-defined inclusion/exclusion criteria may apply

Keywords: multiple myeloma renal insufficiency untreated multiple myeloma
early diagnosis of upper digestive tract disease

Conditions: Squamous Cell Carcinoma; Breath Test; Digestive System Disease; Diagnose Disease

Summary: upper digestive tract cancer (udc) is a major disease burden worldwide encompassing all cancers involving the digestive tract (from oral cavity to duodenum). a majority of patients presenting with this disease are diagnosed late and have poor overall survival rates (\<20%). nice referral guidelines for diagnostic endoscopy are usually associated with late disease. exhaled breath testing is a non-invasive and acceptable technology utilising mass spectrometry (ms) which has shown promise at diagnosing cancer at an early stage. previous research has shown that products formed as a result of metabolism can be measured in breath and saliva (biomarkers). this has the ability to accurately identify patients with upper gastrointestinal (ugi) cancers from breath. our initial pilot data has demonstrated that changes in the breakdown of metabolites release volatile organic compounds (voc) which can be measured with ms. this data is supported by other patient studies. however no previous study has been performed utilising a non-invasive technique with breath and saliva. thus the aim of this study is to identify vocs present in patients with this disease. in this multi-centre study the investigators want to overcome the limitations of previous work by utilising non-invasive samples (breath, saliva and urine) in patients in multiple sites. the investigators aim to conduct a study in patients with udc and those without. the investigators hope that the results of this study will provide evidence for large scale analysis of patients with this disease, demonstrate the feasibility of this technique and move this valuable test forward into mainstream medical practice. the major advantage of this test is that it is easy to undertake and painless for the patient. this study of products in breath, saliva and urine will be useful for detecting udc to allow treatment at an early stage, improving overall survival.


Eligibility criteria:
inclusion criteria: * any patient who: * is ≥ 18 years old and below 90 years of age, and: * is undergoing endoscopy as part of their routine clinical care, or: * is undergoing surgical resection of orodigestive tract disease as part of their routine clinical care, or: * is undergoing treatment of orodigestive tract disease as part of their routine clinical care exclusion criteria: * any patient who: * lacks capacity or is unable to provide informed consent. * any patient below 18 years of age or over 90 years of age.
conservative treatment vs. volar plating of distal radius fractures

Conditions: Distal Radius Fractures

Summary: a prospective, randomized controlled single-center trial with 80 patients aged 50 years and above to compare the functional and radiological results of conservative treatment and volar fixed-angle plating in the management of distal radius fracture

volar plating has became as a standard approach for treating unstable distal radius fractures. the incidence of surgically treated patients with distal radius fractures has increased many fold from the beginning of this millennium, owing mostly to increased number of volar platings. the most striking increase of plate fixations has occurred in older patient groups, especially in females. with volar fixed-angle plate, very near-anatomic, stable fixation with relatively low complication rate, can be achieved even in osteoporotic bone. there are only few randomized, prospective studies comparing results of volar plating and conservative treatment, comparing patients aged over 65 years. quite little is known of the results comparing conservative treatment and volar plating in patients aged below 65 years. main goal of our study was to compare the functional and radiological results of conservative treatment and volar fixed-angle plating in the management of distal radius fracture in patients aged over 50 years an older.

Eligibility criteria:
inclusion criteria: * patients over 50 years-old * primary dislocated distal radius fracture (ao/ota 23 type a2-3 and c1-2) * primary reduction of fracture is acceptable considering primary conservative treatment exclusion criteria: * bilateral and open fractures and fractures with neurovascular compromise * other major concurrent fracture necessitating treatment of any kind * patients under 50 years of age * previous ipsilateral distal radius fracture * inflammatory joint disease * significant radiocarpal-joint degeneration * patient's bad co-operation or major co-morbidity making an operation contraindicated
community-based continence promotion: sustaining healthy aging in place (shaip) through mind over matter (mom)

Conditions: Fecal Incontinence in Old Age; Urinary Incontinence in Old Age

Summary: the goal of this study is to obtain data about the effectiveness, reach, adoption, and implementation potential of an innovative, combined urinary/bowel continence workshop through a randomized controlled trial in six wisconsin communities. this three-session workshop is based on proven principles of behavior change addressing urinary and bowel continence self-management and health education and has been developed specifically for administration to women age 50 and older in senior centers. we hypothesize that workshop participants will experience improvements in urinary and bowel incontinence symptoms, will have increased levels of care-seeking and self-efficacy for these conditions, and will maintain the self-management strategies taught in the workshop 3 months following completion of the workshop. we further hypothesize that this workshop will reach its intended target population (independent senior women with incontinence) and will improve their mental health by destigmatizing the condition of incontinence.


Eligibility criteria:
inclusion criteria: * qualifying symptoms within last 3 months * able to speak english * lives independently exclusion criteria: * new treatment for target symptoms within last 3 months
superficial dry needling versus deep dry needling on the upper trapezius

Conditions: Neck Pain

Summary: this study investigates the effect of two different techniques (deep dry needling and superficial dry needling) on the latent myofascial trigger point in the upper trapezius. subjects with latent myofascial trigger point in this location of the muscle will be identified and will be randomly assigned to one out of the three groups: deep dry needling, superficial dry needling or sham dry needling in gastrocnemius muscle. cervical range of motion and pain pressure threshold in the upper trapezius will be registered before, immediately after the intervention, at 24 hours after the intervention, at 72 hours after the intervention and a week after the intervention


Eligibility criteria:
inclusion criteria: * present the latent myofascial trigger point (mtp) 1 in upper trapezius. * accept participation in the study (signature of informed consent). * be in an age range between 18 and 55 years. * do not present any exclusion criteria. exclusion criteria: * do not present mtp 1 latent in the upper trapezius. * suffering and / or having suffered from upper limb pathologies, deformities or orthopedic injuries that could alter the static and biomechanics of the shoulder and neck. * not clearly identify the mtp 1 in the upper trapezius. * have been diagnosed with fibromyalgia, myelopathy or radiculopathy. * having contraindicated the technique of dry needling for suffering, for example, coagulation problems. * having suffered a whiplash. * be pregnant. * have used analgesics 24 hours before participating in the study. * having belonephobia. * know the study techniques. * be in physiotherapy treatment and / or have been treated with needle techniques at some time. * having had cervical surgery.
new genes in the carcinogenesis of colorectal cancer

Conditions: Colo-rectal Cancer

Summary: colo rectal cancer is one of the greatest ,mutual malignancies worldwide ,accounting for an estimated 1.3 million new cases and \>500,000 mortality ⁄ year . is the fourth leading cause of cancer-associated mortality worldwide with speedily ,cumulative ,occurrence rate in the worldwide

colo rectal cancer represents a global and local problem, as it is one of the commonest types of cancer all over the world. globally, colo rectal cancer in women (9.2% of diagnoses) it is the second most common cause of cancer . it is the third most common in men (10.0%). after lung, stomach, and liver cancer it is the fourth most common cause of cancer death. cancer is a multistep procedure resulting from an ongoing accretion of genetic and epigenetic fluctuations to the genome. spartin is a protein that in humans is encoded by the spg20 gene. this protein may be involved in endosomal trafficking, microtubule dynamics, or both functions. aberrant promoter methylation of genes is a common epigenetic alteration in colo rectal cancer . this has stimulated the prospect to implement a dependable, reasonable and simple approach for colo rectal detection . the spg20 gene is situated in chromosome band 13q13.3; the spg20 gene converts the spartin protein, which is a multi functional protein that has formerly been recognized to be complicated in intra cellular epidermal growth factor receptor trading , the serine-threonine kinase 31 (stk31) gene was initially identified through cdna subtraction as a testis-specific protein kinase gene expressed in mouse spermatogonia . recently, stk31 has been described as a novel cancer testis (ct) antigen, highly expressed in gastrointestinal cancer cells (colo rectal, gastric and esophageal cancer), while restricted to testis and fetal brain in normal tissues . it was found that spg20 is mutated in troy er syndrome, an hereditary spastic paraplegia

Eligibility criteria:
inclusion criteria: * age between 35-65 * patient with colorectal cancer (at any stage) * both sex included exclusion criteria: * pediatric patients * patient with insufficient data * cardiac patient * pregnant women
personalized computerized training program for cognitive dysfunction after covid-19

Conditions: Post-Acute COVID-19; Long COVID

Summary: this before-and-after study aims to evaluate the usefulness and efficacy of a personalized computerized cognitive training (cct) to improve cognitive function among people with post-acute sequelae of covid-19 (pasc).

through an online platform created for the study, adults who self-reported cognitive impairment more than 3 months after receiving a covid-19 diagnosis will be enlisted and their cognitive status will be assessed using a commercially available test. after determining their level of general cognitive dysfunction, those who qualify and meet the inclusion criteria will be invited to use a customized computerized cognitive training (cct) program at home and to complete as many daily training sessions as they would want over the course of eight weeks. the sessions will consist of gamified cognitively demanding exercises that target five cognitive skills: attention, coordination, memory, perception, and reasoning. participants will also complete the general cognitive function assessment at the end of the intervention period, and the differences between the cognitive scores obtained before and after this period will be used as the main outcome measure. additional analysis will be performed to better characterize the impact of the cct by exploring the role of the age of the participants, their self-perceive health at baseline, the intensity of the training and the time from initial covid-19 infection.

Eligibility criteria:
inclusion criteria: * adults (older than 18 years old). * history of infection with covid-19 at least 3 months prior to expression of interest. * presence of self-perceived cognitive dysfunction associated with pacs (concentration problems or brain fog). exclusion criteria: * completion of less than 10 training sessions. * not completing the final evaluation after the 8-week training period.

Keywords: long covid computerized cognitive training post-acute sequeale of covid-19 cognitive dysfunction brain fog
systematic initiative to increase activity in schools

Conditions: Obesity; Cardiovascular Fitness

Summary: this initiative is a prospective study evaluating the effects of implementing physical activity strategies in wisconsin schools with low socioeconomic status on childhood fitness.

this initiative is a prospective study evaluating the effects of implementing physical activity strategies in wisconsin schools with low socioeconomic status on childhood fitness. forty-nine schools participated in the study providing de-identified fitness data for students for 3 consecutive years. twenty-five schools initiated physical activity interventions in year one and 24 schools initiating physical activity interventions in year two.

Eligibility criteria:
inclusion criteria: * all children between 3rd and 8th grade exclusion criteria: * children who could not perform pacer (exercise)
improvement on gmfcs level of patients with cerebral palsy treated by repeated botulinum toxin-a

Conditions: Cerebral Palsy

Summary: the aim of this retrospective, monocenter, observational study is to evaluate the changes in gmfcs levels of children with cerebral palsy (cp) who received repeated botulinum toxin-a (bont-a) injections in the lower limb(s) with an integrated treatment approach in kocaeli university department of pmr and izmit rehabilitation center.

it is generally agreed that children with cp reach their gross motor potential by the age of 3.5-5 and a child or young person over the age of 5 years will not improve their gmfcs level. bont-a is an important treatment in children with cp because it is safe in young children and allows combined treatment. the reduction in muscle tone by this selective treatment provides an opportunity to allow and optimize the effects of other treatments including orthoses, casting, conventional therapies and activity based functional trainings. for this reason, bont-a injections are always combined with other therapies in kocaeli university department of pmr and izmit rehabilitation center. adjunctive treatments in this department consists of serial casting, orthotics, physical therapy, occupational therapy, cognitive rehabilitation, special educational programs, non invasive brain stimulation with transcranial direct current, neurofeedback, biofeedback, electrical stimulation and other physical therapy modalities, activity based models including functional ambulatory training, constraint induced therapy, bilateral therapy, hippotherapy, music therapy by singing or playing percussive instruments or moving and dancing to music, and robotic rehabilitation. individualized intensive combined treatment plan was applied by an appropriate neurorehab team to each patient within the department as a half day or full day program usually for 3 weeks starting 1 week or 10 days after bont-a injections. in thıs retrospective, monocenter, observational study a software database program will be developed and all the present data about the demographic and clinic properties of the patients, all information about bont-a injections including safety and applied adjunctive treatments will be entered and reviewed.

Eligibility criteria:
inclusion criteria: * all children with a diagnosis of cerebral palsy with respect to rosenbaum criteria * children who received at least 2 repeated bont-a injections to lower limb(s) as well as an integrated treatment approach (an intensive therapy protocol consisted of a half day or entire day program in kocaeli university department of pmr and izmit rehabilitation center) within the last 10 years exclusion criteria: * children who did not receive repeated injections * children who did not receive an intensive therapy protocol
dose escalation study of cyclophosphamide in hiv-infected subjects on haart receiving sb-728-t

Conditions: HIV

Summary: the purpose of the study is to evaluate the safety, tolerability and effect on hiv viral load, of escalating doses of cyclophosphamide administered 1 day prior to sb-728-t infusion.

the objectives of the study are to augment hiv-specific t-cells and to reverse or decrease the progressive destruction of cd4+ t-cells that leads to clinical aids. levels of engraftment vary from negligible to about 10% of the cd4+ t-cells in the vascular compartment. preliminary analyses of haart ti suggest that an anti-hiv effect may correlate with the level of sb-728-t engraftment. concurrently, non-myeloablative lymphodepletion with cyclophosphamide has been demonstrated to enhance engraftment of adoptively transferred t-cells through a variety of mechanisms. the study is being undertaken to increase sb-728-t engraftment through the administration of low non-myeloablative doses of cyclophosphamide.

Eligibility criteria:
inclusion criteria: * male or female, 18 years of age or older with documented hiv diagnosis within 10 years of screening. * must be willing to comply with study-mandated evaluations; including discontinuation of current antiretroviral therapy during the treatment interruption. * must have received at least 6 months of continuous haart therapy and have had undetectable vls for the preceding 3 months. * on stable antiretroviral medication (no changes to treatment within 4 weeks of screening. * cd4+ t-cell count ≥500 cells/µl. * undetectable hiv-1 rna obtained at screening. * anc ≥2500/µl * platelet count ≥200,000/µl exclusion criteria: * acute or chronic hepatitis b or hepatitis c infection. * active or recent (in prior 6 months) aids defining complication. * any cancer or malignancy within the past 5 years, with the exception of successfully treated basal cell or squamous cell carcinoma of the skin or low grade (0 or 1) anal or cervical dysplasia. * current diagnosis of nyha grade 3 or 4 chf, uncontrolled angina or arrhythmias. * history or any features on physical examination indicative of a bleeding diathesis. * received hiv experimental vaccine within 6 months prior to screening, or any previous gene therapy using an integrating vector. * use of chronic corticosteroids, hydroxyurea, or immunomodulating agents within 30 days prior to screening. * use of aspirin, dipyridamole, warfarin or any other medication that is likely to affect platelet function or other aspects of blood coagulation during the 2 week period prior to leukapheresis. * currently participating in another clinical trial or participation in such a trial within 30 days prior to screening visit. * subjects who are currently taking maraviroc or have received maraviroc within 6 months prior to screening.

Keywords: hiv autologous cell therapy cyclophosphamide
behavioral indicators of pain:tool development with concurrent and construct validity

Conditions: Pain

Summary: the purpose of the pilot study is to validate an assesment tool to be used in the assessment of pain in the verbal, congitively intact patient. the ultimate goal is to be able to validate this tool in the non-verbal/cognitively impaired patient.

patinets will be observed for 2 six hour periods. patients will be videotaped; every 10 minutes: emg reading will be obtained; hourly - vital signs, pain score and saliva cortisol from "spit" will be obtained.

Eligibility criteria:
inclusion criteria: * in-patients with pain diagnosis exclusion criteria: * unable to talk and or understand basic instructions * under age 18 or over age 75 * receiving pain medications regularly
the analysis of the impact of 5-minute massage session on the muscle stiffness and tone

Conditions: Musculoskeletal Disorder

Summary: the study design was a randomised, controlled, parallel, two-arm trial. the subjects were randomly assigned to one of the study groups: the intervention group or the control group. the passive mechanical properties, i.e. the stiffness and tone of the medial and lateral gastrocnemius muscle (dominant leg) were assessed. measures were taken twice: in the intervention group before and after the 5-minute massage session, and in the control group at the beginning of the meeting and again after 5 minutes.

the purpose of this study was to determine whether a 5-minute massage, applied to healthy individuals, may change the passive mechanical muscle properties, which supposedly may prevent msds. the study is carried out on the medial and lateral gastrocnemius muscles because of their accessibility and crucial role in locomotion. myotonpro and tmg s2 devices were used to assess the stiffness and radial muscle displacement of the gastrocnemius muscle respectively.

Eligibility criteria:
inclusion criteria: * age between 19 and 24 years; * healthy individuals, with no lower limb pathology; * pa≥600 met-min/week assessed by ipaq questionnaire; * no medical contraindication of massage therapy; * body mass index 18,5 \< bmi ≤ 25kg/m2 * signing the informed consent. exclusion criteria: * pregnant women; * individuals suffering from neurologic or orthopaedic problems; * lower limb surgical interventions; * cancers; * musculoskeletal disorders * body mass index 18,5 \> bmi ≥ 25kg/m2 * the lack of informed consent.

Keywords: massage therapy muscle tone muscle stiffness