Kornimate/medical-research-clean huggingface dataset:
a self-compassion focused intervention for internalized weight bias and weight loss

Conditions: Overweight and Obesity

Summary: the goal of clinical trial is to test a novel weight loss approach combining a standard weight loss and internalized weight bias intervention with self-compassion exercises in overweight adults with moderate to high levels of internalized weight bias. the main question\[s\] it aims to answer are: 1) can participants lose significant weight loss and 2) significantly reduce internalized weight bias. participants will take part in a 12 week novel weight loss approach combining a standard weight loss and internalized weight bias intervention with self-compassion exercises using videoconferencing software.

the goal of clinical trial is to test a novel weight loss approach combining a standard weight loss and internalized weight bias intervention with self-compassion exercises in overweight adults with moderate to high levels of internalized weight bias. the main question\[s\] it aims to answer are: 1) can participants lose significant weight loss and 2) significantly reduce internalized weight bias. participants will take part in a 12-week novel weight loss approach combining a standard weight loss and internalized weight bias intervention with self-compassion exercises using videoconferencing software. the weight loss approach will be modeled after the diabetes prevention program and the approach utilized to reduce internalized weight bias will be kristen neff's self-compassion intervention. each weekly session will utilize webex videoconferencing software and last approximately 60-90 minutes.

Eligibility criteria:
inclusion criteria: * bmi ≥ 25, ≥ 18 years old * smartphone access * wbis score ≥ 4 exclusion criteria: * type i diabetes, uncontrolled hypertension, cardiovascular event in past year, any major active kidney, liver, cardio, or cerebrovascular disease, * musculoskeletal problems that would prevent physical activity, * current weight loss medication or weight loss program, * history of bariatric surgery, * pregnant or breastfeeding, * eating disorder except binge eating disorder
open-label safety extension study of 5 and 10 mg of vortioxetine (lu aa21004) in long-term treatment of major depressive disorder in adults

Conditions: Major Depressive Disorder

Summary: the purpose of the study is to evaluate long-term safety and tolerability of vortioxetine over a period of 52 weeks in patients with major depressive disorder (mdd) having completed 6-week acute treatment in study nct00839423 / 11492a.


Eligibility criteria:
inclusion criteria: - patients who completed 6-week short-term treatment study for major depressive episode (mde), nct00839423 / 11492a, followed by a 2-week taper period exclusion criteria: * any current psychiatric disorder other than mdd as defined in the diagnostic and statistical manual of mental disorders, 4th edition, text revision (dsm-iv tr) * female patients of childbearing potential who are not using effective contraception * use of any psychoactive medication other protocol-defined inclusion and exclusion criteria may apply.

Keywords: major depressive disorder long-term safety open-label
interleukin-4 in pityriasis lichenoides chronica

Conditions: Pityriasis Lichenoides

Summary: assessment of the level of interleukin 4 (il-4) in the lesional skin and serum of plc patients and compare its level with healthy controls.

measuring the level of interleukin 4 in lesional skin and it's serum level using eliza in patients with pityriasis lichenoides chronica and comparing the levels with healthy controls levels

Eligibility criteria:
inclusion criteria: * patients with pityriasis lichenoides chronica (plc): either with the classical presentation papular or hypo-pigmented macules and patches that proved histopathologically to be plc. * both genders * age group ≥ 8 years exclusion criteria: * patients with other skin diseases * patient received treatment for plc within period less than three months * pregnant patients * lactating patients
vh-ivus plaque composition analysis by fractional flow reserve

Conditions: Coronary Disease

Summary: recent clinical trials demonstrated that virtual histology-intravascular ultrasound (vh-ivus) is a useful test predicting clinical outcomes of the coronary artery disease (cad). thin cap fibroatheroma (vh-tcfa) was proposed a predictor of cardiovascular event by vh-ivus combined with more than 70% plaque burden and less than 4mm² minimal lumen area (mla) by ivus. fractional flow reserve (ffr) is an established index of the physiological significance of a coronary stenosis. recent large scale trials demonstrated ffr guided pci showed favorable clinical outcomes. vh-ivus represents anatomical severity, but ffr represents functional severity of cad. few studies reported relevance between two tests. aim of this study was to investigate whether the geometry and composition of lesions were different under ffr criteria.


Eligibility criteria:
inclusion criteria: * clinical angina pectoris who underwent vh-ivus and ffr during coronary angiography. * agree with informed consent exclusion criteria: * unable to get informed consent * low left ventricular ejection fraction less than 35% * chronic renal failure (cr\>2.0mg/dl) * acute myocardial infarction related coronary artery * allergy to adenosine injection

Keywords: coronary atherosclerosis virtual histology intravascular ultrasound fractional flow reserve
facing eating disorder fears for anorexia nervosa

Conditions: Eating Disorders; Anorexia Nervosa; Anorexia Nervosa in Remission

Summary: fed-f is a modular treatment that enhances exposure therapy with psychoeducation and cognitive skills teaching how to face fears of (a) food, (b) weight gain, (c) interoception/body, and (d) social situations. the study goals are to (1) refine and test the acceptability and feasibility of fed-f treatment (phase i), (2) test if this treatment outperforms treatment as usual (tau) delivered post-acute treatment as adjunctive to stepdown specialty care (phase ii), and (3) to examine if treatment targets the hypothesized mechanism of action: approach behaviors (phase ii). these goals will lead to a highly deployable and accessible virtual treatment targeted at core an mechanisms that predict relapse. specific aims are to (1) refine fed-f into a fully virtual format with input from patients and stakeholders and collect preliminary data (n=10) on its feasibility and acceptability (phase i), (2) conduct a small pilot rct (randomized controlled trial) of fed-f (n=30) as compared to tau (n=30; phase ii), and (3) examine if fed-f targets approach/avoidance behaviors and test if this mechanism is associated with clinical outcomes (phase ii).


Eligibility criteria:
inclusion criteria: * age 18-65 * meets criteria for dsm-5 defined an, an partial remission, or an full remission, atypical anorexia nervosa (aan), aan partial remission, or aan full remission * has been discharged from intensive (i.e., inpatient, residential, or partial hospital program) in the past 6 months exclusion criteria: * under 18 * over 65 * does not meet criteria for dsm-5 defined an, an partial-remission, or an full-remission * high and active suicidality * active mania * active psychosis * medically compromised status including extremely low weight (less than or equal to 75% median bmi for age, sex, and height) * does not meet criteria for dsm-5 defined an, an partial remission, or an full remission, aan, aan partial remission, or aan full remission * has not been discharged from intensive (i.e., inpatient, residential, or partial hospital program) in the past 6 months

Keywords: therapy eating disorder anorexia nervosa treatment relapse prevention virtual treatment
analysis of initial adherence and its impact on long-term adherence to hormonal therapy for breast cancer

Conditions: Breast Cancer

Summary: a trial will be conducted on 200 breast cancer patients with adjuvant hormonal therapy. the study included 6 months baseline measurement, and 12 months intervention. patients will be assigned to high adherence or low adherence group. then, through randomization, low adherence patients will be assigned to the intervention or control group. study coordinator delivers the intervention using the walkon mobile application. control participants receive usual care with continuous monitoring using medication event monitoring system (mems) device.

* baseline measurement (n=200): screening and enrollment * 3-month visit: collecting mems data * 6-month visit: collecting mems data and assigned to the high adherence (n=70) or low adherence group (n=75). the low adherence intervention group (n=75) will be educated about the walkon mobile application. * 12-month visit: control group: collecting mems data intervention group: monthly calls + collecting mems data * 18-month visit: collecting mems data and interview

Eligibility criteria:
inclusion criteria: * stage 0-iii breast cancer * treated with adjuvant hormonal therapy exclusion criteria: * stage iv breast cancer * breast cancer recurrence or metastasis * severe medical illness

Keywords: medication event monitoring system adherence
parallel mapping for ventricular tachycardia

Conditions: Ventricular Tachycardia (V-Tach); Implantable Cardioverter Defibrillator (ICD); Arrythmia

Summary: catheter ablation in patients with ventricular tachycardia using a new mapping algorithm called, parallel mapping, that is aimed to increase the specificity of mapping and the outcome of ablation.

in patients with scar in the hearts after heart attacks, the risk for dangerous abnormal heart rhythms, including sudden death is high. this is because dead muscle fibers are replaced by scar tissue, creating a physiological condition promoting abnormal heart rhythms.these abnormal heart rhythms are called ventricular arrhythmias or ventricular tachycardias. in these patients, ablation procedures can be helpful, however the recurrence rate of arrhythmias after ablation remains unacceptably high. the primary reason for this high recurrence rate is nonspecific mapping methodologies for identifying the heart area responsible for these arrhythmias. therefore, new methods for increasing the specificity of mapping have been the subject of significant research for many years, however implementation of these methods in clinical practice has been challenged by limited technologies. recently, a new mapping technology named "parallel mapping" has been developed, received fda approval and is routinely utilized at the cleveland clinic. however, the workflow of using parallel mapping, and the efficacy of ablation using this technology have not been evaluated.

Eligibility criteria:
inclusion criteria: * age ≥18 years * history of scar-mediated sustained ventricular tachycardia * failure of therapy with anti arrhythmic drugs * implanted icd or a plan for icd implantation after the ablation * willingness to adhere to the study restrictions and comply with all post procedural follow-up requirements * ability to understand the requirements of the study and sign an informed consent exclusion criteria: * patients with reversible causes of ventricular tachycardia including ongoing ischemia or electrolyte abnormalities * contraindication to anticoagulation therapy * stroke within 30 days before enrollment * life expectancy \<1 year * individual has a known, unresolved history of drug use or alcohol dependency lacks the ability to comprehend or follow instructions or would be unlikely or unable to comply with study follow-up requirements * pregnant or breast feeding at time of signing consent * patient undergoing cardiac transplantation * enrolled or participates in other drug or device studies
mindfulness training in the medical health care system

Conditions: Burnout, Professional; Stress; Emotion Regulation

Summary: the purpose of this study is to look at how mindfulness-informed emotional intelligence training may influence how participants think, feel, and act.


Eligibility criteria:
inclusion criteria: 1. individuals who are between 18 and 80 years of age 2. individuals who are fluent english speakers 3. individuals who are able to adequately and independently use electronic devices, such as a laptop, computer, or tablet, and have internet connection 4. individuals who are willing and able to consent to participate in the study exclusion criteria: 1. individuals with an active and untreated mental health issue and/or hospitalization for psychological/mental health issues within the past month
gambling and brief interventions

Conditions: Gambling

Summary: this study will compare four different combinations and durations of motivational enhancement therapy, cognitive behavioral therapy, and brief advice treatments for gambling versus a non-intervention condition to determine which is most effective in reducing problem gambling.

gambling, if done compulsively, can cause psychological, physical, social, and vocational problems. problem gambling, or compulsive gambling, is a progressive addiction characterized by a preoccupation with gambling, a need to bet more money more frequently, restlessness or irritability when attempting to stop, and gambling more to make up for losses. this study will compare four different combinations and durations of motivational enhancement therapy (met), cognitive behavioral therapy (cbt), and brief advice treatments for gambling versus a non-intervention condition to determine which is most effective in reducing problem gambling. this open-label study will last a total of 9 months. participants will be randomly assigned to one of four groups. group 1 will have no intervention and will be instructed to call if they experience any gambling problems. group 2 will receive 5 minutes of education on the hazards of heavy gambling. in addition, they will receive a 1-page brochure on problem gambling and its consequences. group 3 will receive a 1-hour session of met focused on increasing commitment to change by raising awareness of personal consequences of gambling. group 4 will receive the same met session as group 3, as well as three 1-hour sessions of cbt focused on identifying specific social and mood cues associated with gambling. treatment will end at week 4. participants will have two follow-up sessions held over the phone at week 6 and again 9 months after enrollment. gambling behavior, employment status, alcohol and drug use, psychiatric problems, and family problems will be assessed.

Eligibility criteria:
inclusion criteria: * meets criteria for problem gambling * two or more gambling episodes per month for 2 months prior to enrollment * has spent at least $50 per month on gambling for 2 months prior to enrollment exclusion criteria: * any uncontrolled psychiatric conditions * severe cognitive impairment * currently receiving treatment for gambling

Keywords: brief interventions motivational enhancement therapy cognitive behavioral therapy
hypersensitivity reduction efficacy: 5% potassium nitrate toothpaste compared to colgate cavity protection toothpaste

Conditions: Dentin Hypersensitivity

Summary: assess the clinical efficacy of 5% potassium nitrate toothpaste (colgate-palmolive company, new york, ny, usa) on providing dentinal hypersensitivity relief (tactile and air blast) in comparison to colgate cavity protection toothpaste (colgate-palmolive company, new york, ny, usa) over an eight-week period


Eligibility criteria:
inclusion criteria: * male and female subjects, ages 18-70, inclusive.- availability for the eight-week duration of the study. * two sensitive teeth, which must be anterior to the molars, and demonstrate cervical erosion/abrasion or gingival recession. * qualifying response to tactile stimuli (yeaple probe) as defined by a score between 10-50 gms. of force. * qualifying response to the air blast stimuli as defined by a score of 2 or 3 on the schiff cold air sensitivity scale. * subjects need to satisfy the qualifying response to stimuli for both the parameters assessed (tactile or air) on two teeth to be entered into the study. * good general health with no known allergies to products being tested. * use of a non-desensitizing dentifrice for three months prior to entry into the study. * signed informed consent form exclusion criteria: * gross oral pathology, chronic disease, or history of allergy to test products. * advanced periodontal disease or treatment for periodontal disease (including surgery) within the past twelve months. * sensitive teeth with a mobility greater than one. * teeth with extensive/defective restorations (including prosthetic crowns), suspected pulpitis, caries, cracked enamel, or used as abutments for removable partial dentures. * current use of anticonvulsants, antihistamines, antidepressants, sedatives, tranquilizers, anti-inflammatory drugs, or daily use of analgesics. * participation in a desensitizing dentifrice study or regular use of a desensitizing dentifrice within the past three months. * current participation in any other clinical study. * pregnant or lactating subjects. * allergies to oral care products, personal care consumer products, or their ingredients. * medical condition which prohibits not eating/drinking for 4 hours. * use in the past of the three test dentifrices.
neurocognitive and neurobiological improvement in adhd children with high protein diet

Conditions: ADD; ADHD

Summary: multicenter, prospective, randomized, comparative and controlled study about the beneficial effects in behavior and brain connectivity of different dietary patterns in 100 children with adhd between 7 and 12 years, followed up for 3 months of nutritional therapy.

we collect electroencephalogram (eeg), event related potentials (erp) data, and behavior parameters in add/adhd children that not take stimulants or other drugs during study. they would only follow some nutritional recommendations based on increasing the amount of dietary protein and fast carbohydrates decrease. the duration of the study will be 6 months, 3 months for recruitment and 3 months for dietary treatment.

Eligibility criteria:
inclusion criteria: * adhd diagnosed 12 months before * no take medication * bmi above the 25th percentile * wiesel score between 80 and 100 (about 120) * patients who agree to participate and whose guardians signed the informed consent form exclusion criteria: * eating disorders * psychosis, bipolar disorder or depression * kidney or liver failure * diabetes * diuretic or cortisone treatment * haematological problems * suprarenal diseases * cancer * brain injury * cardiovascular or arrhythmia problems

Keywords: add adhd proteins dietary nutrition qeeg erp ica
the influence of daily honey consumption on ir in obese women with ir

Conditions: Insulin Resistance

Summary: the main objective of the study is to evaluate the effects of daily honey consumption on insulin resistance as a preventive measure against diabetes. in women with insulin resistance.

the prevalence rates of insulin resistance (ir) and its health consequences are increasing worldwide. the reputation of honey as a healthy alternative for sugar is largely accepted. honey contains several bioactive constituents; however, its effect on ir measures and glycemic control is yet to be assessed. we aim to evaluate the effect of daily consumption of honey on ir and inflammatory status measures in obese women with insulin resistance in a free-living controlled intervention study. sixty obese adult females with insulin resistance will be recruited from the community of the university of jordan and from patients at the endocrine unit at the university of jordan hospital. participants will be randomly assigned into one of two treatment groups, honey group or jell-o group. participants will consume a daily dose of 0.5 mg per kg of body weight of the prescribed treatment for 6 months. the effects of daily consumption of honey on ir, serum concentration of several inflammatory biomarkers, and body fatness will be evaluated. the results of this study would reveal the antidiabetic effect of the bioactive compounds in honey in insulin-resistant obese women.

Eligibility criteria:
inclusion criteria: * female * 19-45 years * obese (bmi \>= 30 kg/m\^2) * premenopausal exclusion criteria: * individual who use any drug or supplements known to affect lipid, glucose for at least the last three months. * individual who previous insulin treatment * smokers * individual who have diabetes, kidney, liver, or hormonal diseases * individual who have significant weight changes \> 5% during the past 6 months * women who are postmenopausal

Keywords: insulin resistance
identification of clinically significant markers of attrv in pre-symptomatic mutation carriers.

Conditions: Amyloidosis

Summary: the objective of this prospective observational study is to periodically monitor pre-symptomatic subjects carrying a mutation of transthyretin (ttr), identified in the context of a family screening of affected proband, through instrumental methods and clinical scales in order to identify the first signs of clinically significant organ involvement by the disease. healthy asymptomatic carriers will be subjected to regular monitoring through clinical evaluations and instrumental investigations defined by the consensus group (conceicao et al.) in order to validate the criteria defined by this group to define the onset of the disease. a subgroup of carriers with scales and instrumental tests negative for damage to the peripheral nervous system or cardiac, but with subjective symptoms compatible with the disease, will be subjected to further instrumental tests not indicated by consent.


Eligibility criteria:
inclusion criteria 1. pre-symptomatic carriers of ttr mutation in regular follow-up at the centres. 2. signature of the written informed consent. 3. age not less than 10 years compared to the age of onset of the relative with the youngest age of onset and/or a history of bilateral carpal tunnel syndrome undergoing surgery. exclusion criteria * other causes of neuropathies (diabetes; mgus; alcoholism; vitamin deficiency). * other causes of hypertrophic heart disease.
cooking and nutrition education for health among adults with diabetes

Conditions: Diabetes

Summary: this study is a multi-dimensional therapeutic lifestyle program that offers cooking and nutrition education as well as email-based health coaching to diabetic patients in an underserved cleveland community. this is an innovative project as it is one of the first focused efforts within this community to improve diabetes control and prevent diabetes progression through cooking and nutrition as well as to systematically measure both clinical and behavioral outcomes.


Eligibility criteria:
inclusion criteria: * age 18 years or older * current state of ohio medicaid recipient * current diagnosis of diabetes, as reported in the electronic medical record * completed at least one diabetes education visit at stjhc * have daily access to a functional kitchen in home exclusion criteria: * pregnancy or lactation or plans to be pregnant or lactate during study * current alcoholism or abuse of recreational drugs * self-reported or history of hiv or hepatitis or active tuberculosis * travel plans that do not permit full participation especially during the first 8 study visits * recent unexplained weight loss (10 pounds or more in past 3 months) * any diagnosis that would interfere with or prevent a change in diet

Keywords: diabetes cooking nutrition lifestyle medicine