Kornimate/medical-research-clean huggingface dataset:
recovery levels of depression patients and caregiver psychoeducation

Conditions: Psychoeducation

Summary: to determine the effect of psychoeducation given to patients and caregivers on patients' depression and recovery levels, caregivers' emotional expression and family burden levels.

the samples of the research are 'the experiment that was followed up in the inpatient service at adnan menderes university research and practice hospital psychiatry service with diagnoses of f32 (depressive disorder according to icd 10 code) and f33 (recurrent depressive disorder according to icd 10 code) and met the inclusion criteria for the study (n = 46). ) and a control group (n=46) with a total of 92 depression patients and their caregivers. the experimental group patients and their caregivers and their relatives were included in the psychoeducation program application within the framework of the training recommended in the "guide for the treatment of patients with major depressive disorder" published by apa in 2010. this application is a psychosocial treatment program consisting of structured sessions and including an experiential interactional process. data were collected from patients using the beck depression scale, recovery assessment scale; it was collected by caregivers using the emotional expression scale and zarit family burden scale.

Eligibility criteria:
inclusion criteria: * patient selection criteria included in the sample for the research; * being 18 years or older * receiving inpatient treatment with a diagnosis of f32 (depressive disorder) or f33 (recurrent depressive disorder) * does not have a developmental disorder * without psychotic features * not having communication problems * being at least a primary school graduate caregiver selection criteria included in the sample for the research; * being 18 years or older * being the primary caregiver of the patient * being at least a primary school graduate exclusion criteria: * • patient selection criteria for exclusion from the sample for the research; * dsm-v axis i comorbidity caregiver selection criteria for exclusion from the sample for the research; * with mental retardation or psychotic disorder * having speech and hearing disorders * it was created as having one of the diagnoses of a cognitive disorder such as delirium, dementia, or amnestic syndrome.

Keywords: depressive disorders family burden emotional expression psychoeducation
phase iii randomized, double-blind, placebo-controlled study of acellular and whole-cell pertussis vaccines

Conditions: Pertussis

Summary: objectives: i. compare the efficacy of 2 acellular pertussis vaccines vs. whole-cell pertussis vaccine vs. placebo in infants living in italy. ii. compare the relative protection of each of the acellular vaccines vs. the whole-cell vaccine vs. laboratory-confirmed pertussis. iii. assess the relative efficacy of the acellular vaccines with respect to one another. iv. assess the immunogenicity of acellular vs. whole-cell vaccines in the study population. v. compare the frequency of adverse events with each vaccine. vi. compare the frequency of adverse events attributable to the pertussis component in each of the 3 vaccines. vii. assess alternative laboratory diagnostic techniques for pertussis in estimating vaccine efficacy, i.e., mucosal immune response, dna probes, or antibody response to other components of the organism. viii. assess the relative efficacy estimates of each vaccine, using clinical criteria to compare the relative incidence rates in each vaccine group.

protocol outline: this is a randomized, double-blind study. patients are stratified by participating institution and randomly assigned to 1 of 3 vaccines and a placebo vaccine in a 3:3:3:1 ratio. one group receives diphtheria-tetanus-pertussis (dpt) vaccine containing filamentous hemagglutinin (fha), pt-9k/129g, and 69 kda outer membrane protein (omp). a second group receives dpt containing fha and omp. the third group receives dpt containing whole-cell pertussis. the control group receives diphtheria-tetanus (dt) vaccine. all vaccines are administered as an intramuscular or deep subcutaneous injection at 6-12, 13-20, and 21-28 weeks of age. the first vaccine is given at week 12 if hepatitis b or other immune globulin was given at birth. all patients receive a dt booster at 11 months, and are followed every 4 weeks for approximately 20 months.

Eligibility criteria:
protocol entry criteria: --population characteristics-- newborns enrolled at first vaccine clinic visit weight at first vaccination at least third percentile, i.e.: girls: 3.2 to 3.8 kg boys: 3.4 to 4.0 kg no previous illness compatible with pertussis --prior/concurrent therapy-- no prior pertussis vaccination --patient characteristics-- age: over 6 weeks to under 12 weeks renal: no renal failure other: no prior prolonged immunosuppressive therapy no prior systemic corticosteroids, unless duration less than 14 days and at least 48 hours since last dose no major congenital abnormality no failure to thrive no known or possible immune system deficit, e.g.: hiv-infected mother autoimmune anemia lymphoma other erythropoietic disease no perinatal central nervous system disease or damage no history of convulsions mother italian-speaking and accessible by telephone planned residence in clinic district for at least 1 year

Keywords: bacterial infection immunologic disorders and infectious disorders pertussis rare disease
identification the expression of sox2 in colorectal cancer tissues

Conditions: Colorectal Cancer

Summary: sox2 has been studied in several types of human solid tumors. the investigators found that sox2 had higher expression level in colorectal cancer and metastatic tissues than normal tissues. so the investigators assumed that whether sox2 plays an important role in the progression and migration of colon cancer.

in our study, we examined sox2 expression in archived human colon cancer tissues and found that its sox2 expression correlates with reduced patient survival, increased tumor grade and metastasis probability.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of colorectal cancer exclusion criteria: * clinical diagnosis characteristics not exactly described in the patients information

Keywords: colorectal cancer invasion metastasis ihc
patient activation through counseling, exercise and mobilization

Conditions: Pancreas Cancer; Biliary Tract Cancer; Non Small Cell Lung Cancer; Advanced Cancer

Summary: pace-mobil-pbl is a prospective randomized controlled trial. the aim is to investigate the effect of a multimodal and exercise-based intervention among older patients with advanced pancreatic cancer, biliary tract cancer, or lung cancer during treatment with first-line palliative chemotherapy, immunotherapy or targeted therapy. the hypotheses: that the multimodal intervention will increase or maintain physical function levels and strength, reduce symptoms and side-effects, improve quality of life, reduce treatment-related complications and hospital admissions, and reduce risk of cancer cachexia and sarcopenia.


Eligibility criteria:
inclusion criteria, participants must: * be diagnosed with locally advanced or metastatic pancreatic cancer, or locally advanced or metastatic biliary tract cancer, or locally advanced or metastatic non-small cell lung cancer within 12 weeks. * have unresectable cancer. * be treated with first-line palliative chemotherapy, immunotherapy or targeted therapy at the department of oncology, herlev and gentofte hospital. * have an eastern cooperative oncology group (ecog) performance status ≤2. * have the ability to speak and read danish, and to provide a signed informed consent form. exclusion criteria, patients with: * small-cell lung cancer. * any physical condition that hinder the execution of physical exercise training. * documented and uncontrolled brain metastases that hinder participation in an exercise-based trial, based on the referring oncologist's assessment. * dementia, psychotic disorders, or other cognitive diseases or conditions that hinder participation in a clinical exercise-based trial. * unstable medical disease or history of serious or concurrent illness; any medical condition that might be aggravated by exercise training or that cannot be controlled, including, but not restricted to congestive heart failure (nyha class ii-iv), unstable angina pectoris, implantable cardioverter defibrillator, or myocardial infarction within 6 months, based on the referring oncologist's assessment. in patients with bone metastases: - a bone metastatic burden or location that poses a risk of injury in the performance of exercise training, as assessed by the referring oncologist.

Keywords: older advanced cancer exercise resistance training counseling mobilization
prospective screening programme for malignant tumors

Conditions: Hematologic Tests; Malignant Tumor

Summary: in prospective part of study, the investigators have found that the parameters of routine blood tests can differentiate varieties of malignancy from healthy people. the investigators enrolled healthy subjects and patients with malignancy that aged from 18 to 85，and collected their clinical data and blood tests result to build the model.and retrospectlly enroll healthy subjects and patients to test the model.


Eligibility criteria:
for the cohort of healthy people inclusion criteria: 1. asymptomatic persons between the ages of 18 to 80 years 2. chinese ethnicity 3. after 3 year follow-up, diagnosed with no malignant disease 4. subject underwent routine blood tests in our center exclusion criteria: 1.with a history of malignant disease for the cohort of patients with malignancy inclusion criteria: 1. diagnosis with the following malignant disease，breast cancer, lung cancer, gastric cancer， esophageal cancer，colorectal cancer，nasopharyngeal cancer，liver cancer and cervical cancer 2. subject underwent routine blood tests in our center
awareness of osteoporosis in patients with hepatitis c infection

Conditions: Hepatitis C; Osteoporosis; Osteoporosis Risk

Summary: osteoporosis is a condition that describes compromised skeletal microarchitecture in general, with clinical signs of decreased bone mineral density. patients with hepatitis c virus infection are at increased risk for developing osteoporosis. identifying whether patients with hepatitis c virus infection have information and awareness about this disease is crucial. this study is aimed to investigate awareness and knowledge of osteoporosis in patients with hepatitis c virus infection.

osteoporosis is a common disease of bone loss. the reduced bone strength predisposes an increased risk for fractures in older individuals. it can affect people from different ethnicity. many factors increase the risk of osteoporosis, including age, postmenopausal state, glucocorticoid use, low body weight, calcium, vitamin d, immobility, and chronic inflammation. patients with hepatitis c virus infection are at high risk of developing osteoporosis due to chronic inflammation and their medications. patients' knowledge and awareness about osteoporosis are essential for early detection, implementation of lifestyle changes, and treatment compliance. this study aimed to investigate osteoporosis awareness and knowledge about osteoporosis in patients with hepatitis c virus infection.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of hepatitis b virus infection * must be between the ages of 18 and 90 * must give consent to participate in the study exclusion criteria: • not giving consent
transcutaneous spinal cord stimulation with bladder and pelvic floor muscle training

Conditions: Spinal Cord Injuries

Summary: spinal cord injury (sci) disrupts signals between the brain and the rest of the body, this includes signals needed to control the bladder and bowels. spinal cord stimulation (scs) (electrical stimulation through electrodes placed on the skin over the spine) has shown potential to improve bladder function. additionally pelvic floor muscle training (pfmt), has been shown to help control bladder overactivity and reduce incontinence in people with a sci. this study will investigate pfmt with scs, and its effects on restoring bladder function, and continence. we aim to recruit 25 participants. those eligible will be patients from the london spinal cord injury centre with a supra-sacral sci (\>6 months post-injury), aged 16 years old and above.

the first five participants who volunteer will be invited to complete 'scs optimisation'. testing different scs electrode positions and stimulation parameters with pelvic floor exercises and during urodynamics (measurement of pressure changes during filling and emptying of the bladder). for the main study, all participants will complete baseline assessments (week 1) which include: bladder, bowel, sexual function, and quality of life questionnaires, a pelvic floor assessment, and urodynamics. assessments will be repeated at week 8, and week 14. after baseline assessments, participants will be randomly allocated to one of two groups. the intervention group will receive 8-weeks of at home pfmt, this will include 3 face-to-face visits, daily text reminders, and a weekly phone call. the control group will continue with usual care for 8-weeks. at the end of the 8-weeks, all participants will be re-assessed, and will then complete a single session of scs with urodynamics. participants will return for their final assessment 6-weeks later (week 14). participants allocated to the control group will be offered pfmt at the end of the study.

Eligibility criteria:
inclusion criteria: * supra-sacral spinal cord injury over 6 months ago * previous urodynamics and management by the neuro-urology consultants * proven ndo from latest urodynamics exclusion criteria: * participants under 16 years of age * non-stable sci or metastatic cord disease * intra-detrusor botulinum toxin injections in previous 6 months * bladder infection on day of investigation * pregnant or trying for a baby (females) * cardiac pacemaker, bladder stimulator or baclofen pump in situ * metal work at thoraco-lumbar level of stimulation * poorly controlled autonomic dysreflexia * currently involved in a clinical trial * previous surgical intervention on bladder/sphincters * active sepsis * poorly controlled epilepsy. acceptable where epilepsy is controlled by drugs or there have been no fits experienced for a reasonable period * patients with a cancerous tumour in the area of the electrical stimulation * patients without the capacity to consent

Keywords: spinal cord stimulation pelvic floor physiotherapy incontinence bladder overactivity neurogenic detrusor overactivity
a home-based module to promote mindful breathing awareness for copd patients

Conditions: COPD

Summary: the purpose of this study is to develop a mindful breathing module to an already effective and developed home based rehabilitation program for guiding copd patients in a mindful breathing practice and further palliate breathlessness and anxiety.

a breathing technique called pursed lipped breathing (plb) has been proven to be beneficial for patients with copd. plb can ease shortness of breath and reduce stress and anxiety. this study will develop a mindful plb module to compliment an already developed home based pulmonary rehabilitation program. in this study, patients will be randomized to either a group that does the home based pulmonary rehabilitation with the mindful breathing module and health coaching or a group that does the home based pulmonary rehabilitation with health coaching without the mindful breathing module. both groups will do the home based pulmonary rehabilitation for 12 weeks. in addition there are questionnaires and the wearing of an activity monitor when you sign up and at 3 and 6 months.

Eligibility criteria:
inclusion criteria: * adults, age ≥ 40 years old. * clinical diagnosis of chronic obstructive pulmonary disease (copd). * at least 10 pack years of smoking. exclusion criteria: * unable to do mild exercise (orthopedic-neurologic problems or confined to a bed). * unable to follow commands (cognitive impairment). * have a high likelihood of being lost to follow-up (active alcohol or drug abuse). * live in an area that does not have cellular service (verizon).
ct-based radiomics of aln pcr (ypn0) in breast cancer undergoing nac

Conditions: Triple-negative Breast Cancer; HER2-positive Breast Cancer

Summary: this is a prospective, single-center, non-randomized, non-controlled observational study.

almost 55-62% of patients with triple-negative or human epidermal growth factor receptor 2 (her2) positive, node-positive breast cancer achieve an axillary pathologic complete remission (pcr) after neoadjuvant chemotherapy (nac). to avoid surgery post-nac, it is paramount to accurately identify patients who achieve pcr in axillary lymph node (aln). we found that patients with normal-appearing lymph nodes on computed tomography (ct) based radiomics of the axilla after chemotherapy had a lower risk of developing residual nodal disease. however, the features of ct-based radiomics for pcr aln following nac has not been established yet. this study aimed to assess the performance of ct-based radiomics in evaluating the response and predicting pcr of metastatic lymph nodes after nac in breast cancer patients.

Eligibility criteria:
inclusion criteria: * triple-negative or her2-positve invasive breast cancer with axillary lymph node metastasis by confirmed by fine needle aspiration or core needle biopsy. * underwent computed tomography for assessment of axillary lymph node status before and after neoadjuvant chemotherapy. * attend the study voluntarily, sign the informed consent. exclusion criteria: * contradiction for adjuvant chemotherapy. * contradiction for proceeding surgery.

Keywords: breast cancer neoadjuvant chemotherapy lymph node radiomic pathologic complete remission
impacts of kebbi robot intervention for older adults with mild dementia

Conditions: Mild Cognitive Impairment (MCI)

Summary: the goal of this clinical trial is to examine the immediate and sustained effects of an intensive kebbi robot intervention on cognitive functions, heart rate variability (hrv), and psychological changes for older adults with mild dementia in long-term care (ltc). the main questions it aims to answer are: * are intensive kebbi robot interventions effective in improving cognitive functions, hrv, and psychological changes for older adults with mild dementia in ltc? * what are the participants\&#39; experiences and perceptions after intensive kebbi robot interventions? researchers will compare intensive kebbi robot interventions to a control group (receiving usual activity) to see if they are effective in improving cognitive functions, hrv, and psychological changes in older adults with mild dementia in ltc. participants will: * participants in the intensive kebbi robot interventions will receive 30 minutes, thrice weekly, for 12 weeks. participants in the control group will receive the usual activity. * the outcome measures will be conducted at three time points: before the intervention (t0), immediately after the end of the intervention (t1), and one month after the end of the intervention (t2). * outcome measurements include the cognitive outcomes: mini-mental state examination (mmse), montreal cognitive assessment (moca), finger tapping test (ftt); heart rate variability (hrv); psychological changes: the geriatric depression scale-short form (gds-sf), the ucla loneliness scale version 3 (ucla- version 3), and the friendship scale.


Eligibility criteria:
inclusion criteria: * aged 65 years or over; * mild dementia (mmse score between (19-24) according to level of education; * an ability to communicate in mandarin or taiwanese; * has been admitted in dementia daycare centers at least 3 months. exclusion criteria: * have severe difficulty in communication; * are totally dependent on carers for daily activity; * have a diagnosed infectious disease, moderate or severe dementia, and severe mental illness such as schizophrenia and delusional disorder

Keywords: interactive robot heart rate variability psychological changes dementia
elastography for evaluating cervical maturity in preparation for labor induction at 37 to 42 weeks of gestation

Conditions: Labor, Induced

Summary: the primary objective of this study is to determine if a cervical hardness score (determined by cervical ultrasound with elastography) can predict delivery mode (vaginal versus cesarian for slow dilatation (more than 2-3h without fetal suffering) regardless of the induction mode (ocytocin alone or with an intravaginal device releasing pge2).

the secondary objectives of this study are: a. to determine composite criteria (combining elastographic, parity and bishop score information) that predict delivery mode. b. to determine the prognostic value of elastography as concerns delivery within 24 hours among patients induced via oxytocin with an intravaginal device releasing pge2 (bishop score \< 6). c. to determine the prognostic value of elastography as concerns delivery mode (vaginal versus cesarian for slow dilatation (more than 2-3h without fetal suffering))among patients induced via oxytocin alone. d. to evaluate the intra- and inter-operator reproducibility of the cervical hardness score determined via elastography. e. to evaluate the economic impact of using the cervical hardness score from the point of view of the french social system (french health insurance) and the hospital.

Eligibility criteria:
inclusion criteria: * the patient must have given her informed and signed consent * the patient must be insured or beneficiary of a health insurance plan * pregnant woman with a medical indication for pre-term labor induction: 37 to 42 weeks of gestation. exclusion criteria: * the patient is in an exclusion period determined by a previous study * the patient is under judicial protection, under tutorship or curatorship * the patient refuses to sign the consent * it is impossible to correctly inform the patient * history of cervical surgery * malformation of the cervix

Keywords: induced pre-term labor
an affect management intervention for juvenile offenders

Conditions: HIV Infections

Summary: adolescents are at risk for hiv because of sexual and drug behavior initiated during this developmental period. adolescents in the juvenile justice system are at increased risk for hiv due to higher rates of substance use and psychopathology than their non-offending peers. juvenile justice youth may therefore also be less likely to benefit from frequently used skills based interventions. it appears that emotional lability, frequently found in this population, disrupts skills learned. this project will implement and evaluate an affect management hiv prevention intervention for adolescents in a juvenile drug court program. affect management and general health promotion interventions will be compared to determine which intervention best reduces risk behavior among adolescents in the drug court.


Eligibility criteria:
inclusion criteria: * adolescents enrolled in the juvenile drug court program exclusion criteria: * adolescent is hiv positive * adolescent is pregnant * adolescent is developmentally delayed * adolescent has history of sexual crime

Keywords: hiv prevention hiv seronegativity