Kornimate/medical-research-clean huggingface dataset:
the national institutes of health measure of healing experience of all life stressors

Conditions: Severe Chronic Illness

Summary: nih-healing experience in all life stressors (nih-heals) is a 35 item self-report questionnaire developed by the nih clinical center pain and palliative care. it assesses an individual's mechanisms for coping as a means to reach "healing" during life's difficult situations and/or life limiting challenges. the factorial structure of the tool has been recently re-examined with 200 patients. the three main factors are: connection (including religious, spiritual, interpersonal), reflection/ introspection, and trust/acceptance.

at the clinical center pain and palliative care service (ppcs) we have developed a pscyho-social-spiritual measure, the healing experience in all life stressors (heals), that focuses on the healing experience in people with severe and life limiting illness. we have validated this tool further in order to be able to identify those individuals who may benefit from additional interventions to cope with their illness and even assist them in reaching a healing experience that is possible even in the midst of their unfavorable circumstances. identification of vulnerable individuals as well individuals who do have transformative experience after being diagnosed with severe and life limiting illness, has far-reaching impact on the quality of patient care for the very sick patients.

Eligibility criteria:
inclusion criteria: * age of 18 or above * the ability to read and write in english * the presence or history of a serious and/or life-threatening disease

Keywords: healing spiritual psycho-social-spiritual growth chronic illness patient care
optimization of cardiac resynchronization therapy by non-invasive imaging of cardiac electrophysiology

Conditions: Heart Failure

Summary: the principal aim is to analyze total left and right ventricular activation time in different crt device programming algorithms (syncav) measured by non-invasive electrophysiology

patient specific anatomic parameters taken from the cardiac magnetic resonance examination will be the base for a semiautomatic model incorporating the conductivity of the heart, the lungs, blood and the torso. for this reason, a software package (amira developer, tgs template graphics software, france) has been adapted to calculate a quasi static approximation of maxwell equations. after fusion of the t1 cmr scan and the ecg electrodes a model-based bidomain fem is used for a step-wise measurement of the local activation times (resting potential: 290 mv; plateau: 0 mv; acceleration time: 3 ms) both ende- and epicardially.

Eligibility criteria:
inclusion criteria: * patients after successful implantation of a crt-d or crt-p device in whom a cardiac magnetic resonance examination is possible and the device is equipped with the syncav® programming software * left bundle branch block before crt implantation * pq interval ≤ 250 ms before implantation exclusion criteria: * high-grade av block * any contraindication concerning a safe cmr performance including claustrophobia * terminal heart failure (nyha iv) or cardiac decompensation * life expectancy \< 1 year * women with child-bearing potential, pregnancy * drug abusus
the benefit of hemodialysis plus hemoperfusion on mortality

Conditions: End-stage Renal Disease

Summary: this multi-center, open-label, randomized controlled trial aims to investigate the efficacy of hemoperfusion (hp) combined with hemodialysis (hd) by evaluating all-cause mortality and cardiovascular mortality in maintenance hemodialysis patients.

in this hd/hpvshd trial, we plan to enroll 1364 maintenance hemodialysis patients. eleven medical centers in shanghai metropolitan area have explicitly expressed interest to participate. participants will be randomized to receive hemodialysis plus hemoperfusion or hemodialysis alone at a 1:1 ratio after 1-month run-in period. in both arms, patients will receive lblood purification (including low-flux hemodialysis, high-flux hemodialysis, or hemodiafiltration) treatment at least 10 hours per week. in the experiment group, in addition to the treatments in the control arm, hemoperfusion will be conducted at least once every two weeks using a ha130 resin hemoperfusion apparatus containing 130ml resin. follow-up is scheduled at 3, 6, 12, 18, 24 and up to 48 months after randomization, and will consist the following: routine physical examinations, standard lab panels (blood routine, liver/kidney functions, tests of the coagulation system, etc.), chest x-ray, electrocardiogram, echocardiography, heart function rating (based on new york heart association grading). dialysis adequacy defined by standard kt/v will be calculated. adverse events will be assessed according to the international conference on harmonization guidelines. the primary outcomes will include 24-month all-cause mortality. secondary outcomes will include cardiovascular-related mortality, the occurrence of major cardiovascular events and the quality of life (kidney disease quality of life short form).

Eligibility criteria:
patients must meet all of the following criteria are eligible: 1. age ≥ 18 years old 2. regular blood purification treatment at least 3 months before enrolled in this study 3) standard kt/v ≥ 1.2 subjects with one of more of the following conditions will be excluded: 1. white blood cell count \< 4×10\^9/l and / or platelet count \< 100×10\^9/l 2. cerebral hemorrhage in the past 12 weeks 3. maces in the past 8 weeks 4. severe heart failure (new york heart association \[nyha\] class iv) 5. active gastrointestinal bleeding, or coagulation dysfunction 6. malignant tumor 7. active infection 8. pregnancy or lactation 9) mental disabilities

Keywords: hemoperfusion hemodialysis mortality
ai to support mental health case management providers

Conditions: Depressive Disorder; Anxiety Disorders; Substance Use Disorders; Post Traumatic Stress Disorder

Summary: the goal of this clinical trial is to assess the effectiveness of an artificial intelligence (ai) platform for case managers in a nonprofit health system specializing in mental health and substance use disorder. the main questions it aims to answer are: 1. is the ai platform acceptable and feasible for case managers? 2. does the ai platform improve providers' productivity and reported interventions? participants will be approximately 30 case managers and their 250 adult clients receiving case management services. researchers will compare the provider productivity and work satisfaction prior to the implementation of the ai platform to following its implementation.


Eligibility criteria:
for providers: participating providers must be centerstone case managers. for clients: inclusion criteria: 1. participants must be adults. 2. participants must be receiving case management services from a centerstone provider exclusion criteria: 1. participants currently involved in any other concurrent research study will be excluded to avoid potential confounding factors. 2. participants with any medical conditions or medications that may significantly interfere with the study outcomes will be excluded.

Keywords: case management artificial intelligence provider productivity mental health services provider satisfaction
manual therapy versus conventional rehabilitation protocol on subacromial pain syndrome

Conditions: Subacromial Impingement Syndrome

Summary: this study compares the periodic effects of accelerated rehabilitation protocol (arp) and mulligan mobilization with mowement method (mwm) in subacromial pain syndrome patients rehabilitation. half of the participants will receive arp, while the other half will receive mwm.


Eligibility criteria:
inclusion criteria: * to be in the 18-60 age range, to be cooperative during evaluation and treatment and to accept to participate in the study exclusion criteria: * the presence of adhesive capsulitis, surgical indication or shoulder surgery, cervicothoracic problems (such as stenosis and disc herniation) diagnosed as neurological or inflammatory joint diseases

Keywords: shoulder pain
sleep disordered breathing, apoe, and lipid metabolism

Conditions: Sleep Apnea Syndromes; Lung Diseases

Summary: to examine the relationship between obstructive sleep apnea and lipid metabolism.

background: recent findings suggest interrelationships between obstructive sleep apnea, lipid metabolism, and neurodegeneration. apolipoprotein e epsilon4 (apoe e4), a genetic marker linked to increased cardiovascular disease (cvd) risk and alzheimer's disease (ad), is associated with a two fold increased risk of sleep disordered breathing (sdb), and an increase in severity of apnea symptoms. preliminary data suggest that this association is stronger between the ages of 50 and 65. other experiments suggest dysregulated leptin levels in obstructive sleep apnea (osa). taken together, these findings suggest common pathophysiological mechanisms involving dysregulated lipid metabolism in osa. an understanding of these mechanisms is essential for the prevention and treatment of sdb. design narrative: using case/control and family designs, the study: 1) extends the finding that apolipoprotein e epsilon4 (apoe e4) increases the risk of sleep apnea in the general population; 2) examines if polymorphisms in other genes regulating lipid levels are associated with sleep apnea; 3) studies the relationship between lipid regulatory gene polymorphisms, lipid profile (ldl- cholesterol, hdl-cholesterol, triglycerides), plasma leptin (and other lipid regulatory hormones), and sleep apnea levels. t

Eligibility criteria:
no eligibility criteria
23-gauge pars plana vitrectomy with silicone oil injectionsilicone oil injection with surgical

Conditions: Retinal Detachment

Summary: objective: to evaluate anatomical and visual outcomes of 23-gauge vitrectomy for retinal detachment with silicone oil injection in fifty cases. the rate of recurrence, the incidence of proliferative vitreoretinopathy (pvr) and the value of risk factors. participants and methods: fifty cases with rd with mixture of epiretinal and subretinal membranes were collected. pars plan vitrectomy, 23gauge vitrectomy were done to these cases, then silicone oil removed 6 weeks after primary surgery. main outcome measures: the anatomical success rate,the failure rate ,the rate of retinal breaks in both groups, and reproliferation rate.

50 patients were included if they had retinal detachment, moderate degrees of pvr, pvr ≥ grade c, previous buckle surgery and pseudophakia. a good and correct assessment of the detached retina was done. investigator followed the lincoff rules to find the retinal breaks. investigator performed a three-port vitrectomy: one infusion trocar and two instruments trocars. non-contact wide-angle viewing systems (resight- biom) have a viewing field of 60-130° was used. investigator used perfluorocarbon liquid (pfcl) for attaching the retina with its gravity. then performing pfcl against air exchange.the retina will be attached under air tamponade. laser photocoagulation was performed in the air-filled eye. investigator applied the laser effects confluently surrounding all retinal breaks. then silicone oil (1000 centistokes) was injected as a final step and permanent tamponade.after 3-6 months investigator removed the silicone and examined the retina for 6 weeks after surgery to detect the recurrent cases.

Eligibility criteria:
inclusion criteria: * they had retinal detachment, * moderate degrees of pvr * pvr ≥ grade c * previous buckle surgery * pseudophakia. exclusion criteria: * the retinal tear was greater than 90 degrees * presence of intravitreal foreign body * previous vitrectomy done before * if follow-up data were unavailable for a minimum follow-up of 6 months following the final retinal procedure.

Keywords: retina silicone laser break vitrectomy
zanubrutinib combined with r-chop in newly-diagnosed intravascular large b-cell lymphoma

Conditions: Intravascular Large B-Cell Lymphoma

Summary: this is a prospective single-arm phase ii study, and the purpose of this study is to evaluate the efficiency of zanubrutinib combined with r-chop regimen in newly diagnosed primary intraocular lymphoma. progression-free survival (pfs) of the cohort is the primary endpoint.

all the eligible patients will be treated with zr-chop regimen (rituximab 375mg/m2 iv d1, cyclophosphamide 750mg/m2 iv d1, epirubicin 70mg/m2 iv d1, vindesine 4mg iv d1，prednison 60mg/m2 d1-5 po). an interim evaluation will be performed after 4 cycles, the patients who achieve cr or pr will receive another 4 cycles of zr-chop. the patients with stable disease (sd) or progressed disease (pd) will withdraw from the trial and receive salvage regimens. during the following-up, surveillance physical examination and ct scans should be performed every 6 months for 2 years to determine the status of disease.

Eligibility criteria:
inclusion criteria: * the patient volunteered to participate in the study and signed the informed consent * age ≥18 years old ≤70 years old, male or female * expected survival ≥ 12 weeks * intravascular large b-cell lymphoma confirmed by cytology or histology according to who2016 criteria * never received any anti-tumor therapies. * adequate organ function and adequate bone marrow reserve exclusion criteria: * malignant tumors other than ivlbcl within 5 years prior to screening, except cervical carcinoma in situ, basal cell or squamous cell skin cancer, local prostate cancer after radical surgery, and breast ductal carcinoma in situ after radical surgery * active hiv, hbv, hcv or treponema pallidum infection * any instability of systemic disease, including but not limited to active infection (except local infection), severe cardiac, liver, kidney, or metabolic disease need therapy * female subjects who have been pregnant or breastfeeding, or who plan to conceive during or within 1 year after treatment, or male subjects' partner plans to conceive within 1 year after their cell transfusion * active or uncontrolled infections requiring systemic treatment within 14 days before enrollment

Keywords: intravascular large b-cell lymphoma zanubrutinib r-chop
engagement in hiv primary care services

Conditions: HIV Infections; Unstable Housing

Summary: this study is to look at things that may affect whether or not people who are hiv-infected get into medical care and stay in medical care. some of the things that will be examined include how drug use, hiv disease severity, mental health, housing, trust, feelings of discrimination, social support, relationship with provider, and patient's race and provider's race are linked with whether or not people get health care. people who are enrolled in the study will be interviewed once, and their medical records will be examined.

the purpose of this study is to understand the determinants of entry and engagement in hiv primary care services for blacks and hispanics living in single room occupancy (sro) hotels in bronx and manhattan, ny. more specifically, the goal is to examine baseline cultural characteristics of the patient, health-related characteristics of the patient, the patient-provider relationship, and the impact of community outreach on engagement in health care. the objectives are to: examine the association between trust, relationship with provider, social support, and health beliefs with engagement in hiv primary care services; examine the association between health-related characteristics and engagement in hiv primary care services; examine the association of perceived cultural concordance between provider and patient with engagement in hiv primary care services; and, explore the relationship between community outreach and entry into hiv primary care services. we will be recruiting a convenience sample of 500 black or hispanic hiv-infected adults living in 14 sro hotels (transitional emergency housing) in the bronx and manhattan, ny. we will be conducting interviews through auditory computer-assisted self-interviewing (a-casi) technology, using standardized research instruments administered in english or spanish. we will also be reviewing medical charts and records from citiwide and montefiore appointment databases. understanding barriers to engagement in hiv primary care will lead to development of culturally relevant interventions to assist black and hispanic persons in entering and engaging in hiv treatment. implementation of these interventions will ultimately help reduce disparities in hiv-related healthcare, as well as reduce hiv morbidity and mortality in black and hispanic populations.

Eligibility criteria:
inclusion criteria: * at least 18 years of age, hiv-infected, living in one of 15 different single room occupancy hotels in new york city, english or spanish speaking exclusion criteria: * hiv-negative

Keywords: hiv race unstable housing health services accessibility health services utilization substance abuse aids health services research social support depression trust discrimination
an escape room intervention to help improve breast cancer patients' ability to navigate online access to nutrition information

Conditions: Anatomic Stage I Breast Cancer AJCC v8; Anatomic Stage II Breast Cancer AJCC v8; Anatomic Stage III Breast Cancer AJCC v8

Summary: this clinical trial evaluates an educational escape room intervention for improving awareness of and concern about breast cancer misinformation and reducing vulnerability to believing cancer misinformation among patients with stage i-iii breast cancer. misinformation, or communication about health information that is inaccurate or false, can have serious health consequences for those that believe it. the rise of the access to and use of various sources of information on the internet such as websites and social media has caused the spread of misinformation and disinformation to grow rapidly, resulting in negative consequences on health outcomes. cancer misinformation, in particular, has become an increasingly prevalent issue that poses a real threat to the many cancer patients in the united states. the educational escape room intervention is a game designed to teach participants how to discern whether cancer nutrition information is accurate or may potentially be misinformation. participants are immersed in the narrative while solving puzzles to learn key themes such as the need to talk to their doctors, looking for scientific studies, as well as avoiding fads and trends, miracle cures, anecdotal evidence, and targeted and clickbait ads.

outline: patients complete a baseline before playing the virtual cancer nutrition information escape room game. patients then play the virtual misinformation escape room game consisting of 5 puzzles and a final task over 30-45 minutes on study. following the escape room game, patients complete a post-game survey and debrief interview (15 minutes).

Eligibility criteria:
inclusion criteria: * age 18 years of age or older * english speaking * able to provide informed consent * have access to a computer (desktop or laptop) * have been previously diagnosed with breast cancer (stages i-iii) and currently in active treatment for breast cancer
mdiet - ecological momentary intervention of diet via mobile technology

Conditions: Overweight

Summary: this is a nci funded study which will develop and evaluate a cell phone application (mdiet) that can be used as an assessment and intervention tool to improve dietary behaviors and thus reduce weight in overweight and moderately obese (bmi 25-34.9) men and women ages 25-55.

this research will develop a technologically advanced system for monitoring and intervening on diet behaviors (e.g., food intake, weight). interventions aimed at dietary change are missing a comparable, portable tool. mobile technologies can help fill this gap by providing portable connectivity to expert systems that create specific tailored diet goals based on participant profiles. the expert system can 'push' intervention messages throughout the day during critical point-of-decision moments to aid in decision making among users. the portable device can 'pull' information through prompts and easy-to-use recording. this ecological momentary assessment + ecological momentary intervention format may further encourage healthy behaviors by prompting at critical decision points to improve dietary behaviors.

Eligibility criteria:
inclusion criteria: * participants will be included if they: * are age 25-55 * are overweight or moderately obese * are with a bmi between 25.0-34.9 (as defined by the nih report on obesity (nih 1998) * are able to read (completion of at least the 6th grade) and speak english * provide consent * do not intend to become pregnant or move out of the county for the duration of the intervention (16 weeks). * participants will also be required to have a cell phone that is capable of supporting the mdiet application. * participants may be otherwise healthy or have one or more risk factors for cvd, including uncomplicated type 2 diabetes but will not be enrolled if they have diagnosed cvd. exclusion criteria: participants will be excluded from the study if they have any of the following conditions: * an eating disorder * are currently pregnant * have a strict dietary regimen prescribed by their doctor that will not allow them to comply with intervention guidelines related to dietary changes.

Keywords: overweight cell phone technology
periodontal assessment of a bariatric care population

Conditions: Bariatric Surgery Candidate; Obesity

Summary: our primary aim is to investigate the prevalence and severity of periodonotal disease (pd) in a population of obese patients. our secondary objectives are to: investigate inflammatory biomarkers that have been associated with pd in the saliva of obese patients. investigate the association of fto gene (obesity) polymorphisms with the prevalence of pd in this population. investigate and describe the subgingival microbial flora in obese patients with pd from subgingival dental plaque samples as well as the salivary samples.

overall design and plan of the study this is a cross-sectional association study. the study population will be recruited among individuals attending the uclh centre for weight loss, metabolic \& endocrine surgery (uclh bariatric clinic) and have given written informed consent to the study. experimental design all individuals who consent to this study will receive as part of their routine care a medical examination, where a series of parameters are recorded (including age, gender, smoking status, bio-impedance for full body composition, ethnicity, and body mass index). these data will be copied for this study. a blood sample will also be collected for genetic analysis unless the patients have dna already collected and it has been verified that the results are available. in that case no venepuncture will be needed. all subjects will receive a basic periodontal examination (bpe). for individuals with signs of destructive periodontitis (bpe scores 3-4) full mouth plaque and gingival bleeding scores will also be calculated. in addition to that also a comprehensive full mouth periodontal probing depths assessment will be performed.

Eligibility criteria:
inclusion criteria: each subject must meet all of the following inclusion criteria to be enrolled in the study: 1. subject must be over 18 years of age. 2. subject must have a bmi of higher or equal to 30 kg/ m2 3. subject must have voluntarily given written informed consent. exclusion criteria: subjects meeting any of the following exclusion criteria are not to be enrolled in the study: 1. subject is currently involved in other research involving the use of antibiotics or novel or unknown medications. 2. self-reported pregnancy. 3. subject is on chronic treatment (i.e., two weeks or more) with specific medications known to affect periodontal status (phenytoin or cyclosporine) within one month of baseline visit. 4. subject knowingly has hiv or viral hepatitis. 5. patients are completely edentulous. 6. subject with uncontrolled systemic illnesses. 7. subject is not capable to give informed consent. 8. subjects on chronic antibiotic therapy (ie two weeks or more in the previous month).