Kornimate/medical-research-clean huggingface dataset:
a brief parent-based sleep intervention for adhd children

Conditions: ADHD; Insomnia

Summary: sleep problems are very common in children with adhd, with a prevalence rate as high as 73%, and often pose significant challenges and stress to the families. sleep problems in adhd children are strongly associated with the exacerbation of daytime symptoms, impaired physical health, and poor parental mental health. the present study is a randomised controlled trial to compare the effects of a parent-based sleep intervention for children with adhd (aged 6-12). eligible participants will be randomised to either intervention (two face-to-face consultation sessions and one follow-up phone call) or waiting-list control condition. assessments will be conducted at pre-treatment (baseline), one-week after the intervention (post-treatment), and 3 months after the intervention.


Eligibility criteria:
inclusion criteria: * aged 6-12 years old; * with a clinical diagnosis of adhd (any subtype), as confirmed by the diagnostic interview schedule for children-version-iv (disc-iv); * with parent-reported insomnia (difficulty initiating sleep and/or maintaining sleep). exclusion criteria: * children with a serious medical condition (e.g. severe cerebral palsy) or intellectual disability (iq\<70); * children with a neurological and/or medical condition that may lead to disordered sleep; * suspected clinical sleep disorders (e.g. obstructive sleep apnea, osa) that may potentially contribute to a disruption in sleep continuity and quality, as assessed by the children's sleep habits questionnaire (cshq). if the child is suspected of a clinical sleep disorder, he/she will be referred to appropriate services; * children who are already receiving specialised help (behavioural intervention) for their sleep from a psychologist or at a specialized sleep clinic.

Keywords: sleep adhd behavioural intervention insomnia
evaluation of the effect of laser acupuncture on taxane acute pain syndrome patients

Conditions: Pain Cancer; Joint Pain

Summary: this is a prospectively randomized and double-blinded clinical study. cancer patients were suffered from the taxanes-induced joint pain, and would be advised to receive laser acupuncture in specific points to relieve pain. clinical effects of analgesic changes would be evaluated before and after the intervention. the inflammation associated indices would be further analyzed to reveal the therapeutic mechanism of laser acupuncture. the laser acupuncture was expected to relief taxanes-induced adverse effects in patients and also can improve patients' life quality.

the current clinical study is prospectively randomized and double-blinded, and practice in chang gung memorial hospital in linkou, taoyuan and taipei branches. all 90 participants suffered from taxanes-induced myalgia and arthralgia, and will be randomly assigned into the experimental groups (45 participants) and the control group (45 participants). the experiment group would arrange laser acupuncture on day1 and day3 after taxanes treatment, besides the control group arrange pseudo-laser acupuncture. in the mean while, blood tests were performed with the c-reactive protein, erythrocyte sedimentation rate, interleukin-6 for each participants. evaluation would be records on day1, day3, and day 8 after taxanes treatment.

Eligibility criteria:
inclusion criteria: 1. cancer patients received taxanes treatment and complained with myalgia and arthralgia in the first taxanes treatment course. 2. age between 20-70 years old 3. the nrs (numerical rating scale) score of pain increased more than 2 after the treatment. 4. both 1st and 2nd taxanes treatment with the same dose exclusion criteria: 1. receiving acupuncture or herbal medicine over past three months 2. myalgia and arthralgia were not due to taxanes treatment such osteoarthritis or rheumatic arthritis 3. wounds or skin infections over laser acupuncture points 4. refuse assign information consent or follow study protocol

Keywords: laser acupuncture taxanes chemotherapy cancer myalgia arthralgia
effects of high-intensity interval training on myocardial strain in metabolic syndrome patients

Conditions: High-Intensity Interval Training; Metabolic Syndrome; Myocardial Dysfunction

Summary: the effects of high-intensity interval training on myocardial function will be studied in a group of patients under medical treatment for the components of metabolic syndrome.

objective: to analyze the effects of high-intensity interval training (hiit) on myocardial function of metabolic syndrome patients. methods and design. randomized clinical trial with a control group. project was developed in association with the regional general hospital. pre and post-intervention evaluation after 16 weeks of training for the hiit group. subjects: recruited using adverts published on public medical center boards. up to 30 subjects per group (hiit and control) will be recruited (at least 20% women) measurements. echocardiography: global longitudinal strain (gls), mitral filling parameters, myocardial dimensions, and myocardial wall thickness. cardiorespiratory fitness: maximal oxygen consumption, maximal power output, maximal oxygen pulse. clinical: metabolic syndrome components and derived variables (e.g., triglycerides/high-density lipoprotein ratio) body composition by anthropometric measurements and dual-energy x-ray absorptiometry.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of metabolic syndrome. * capacity to exercise on a stationary bike * inhabitant of the province of toledo exclusion criteria: * untreated cardiovascular disease with hemodynamic instability * untreated respiratory disease, symptomatic. * untreated metabolic disease. * untreated renal disease requiring dialysis. * contraindications for high-intensity exercise training
prevention of drug rash from certain cancer therapies using tretinoin cream

Conditions: Medication Reaction

Summary: this research is being done to study whether using of topical tretinoin can help prevent the common rash that patients often get while taking epidermal growth factor inhibitor (egfr-i) medications such ascetuximab or erlotinib. patients taking egfr-i medications often develop skin irritation and acne-like bumps on their face, chest, and other areas. this rash from egfr-i's is often treated with moisturizers and topical or oral antibiotics. however, there has not yet been a study looking at a way to prevent this common side effect from occurring, and topical tretinoin may be useful in reducing the rash. tretinoin 0.025% cream is approved by the food and drug administration (fda) for the treatment of acne, acne scarring, and photodamage. it is not approved for use in preventing rashes associated with egfr-i's.


Eligibility criteria:
inclusion criteria: * age 18 years or over * scheduled to begin treatment with an egfr inhibitor drug exclusion criteria: * pregnant or nursing * history of bleeding disorder * history of keloids or large, thick, puffy-looking scars in the last 10 years * used topical retinoids in the last year (e.g. tretinoin/retin-a, adapalene/differin, tazarotene/tazorac)

Keywords: cancer chemotherapy egfr inhibitors tretinoin egfri drug rash
matrix rotation flap versus single incision lateral sulcus mammoplasty

Conditions: Breast Cancer Early Stage Breast Cancer (Stage 1-3)

Summary: the study seeks to compare the single-incision lateral mammoplasty technique with the matrix rotation flap in patients with breast carcinoma. the primary outcome assessed is postoperative complications, while secondary outcomes include cosmetic appearance and patient satisfaction.

this study is designed to conduct a comprehensive comparison between two breast-conserving surgical techniques used in the treatment of breast carcinoma: the single-incision lateral mammoplasty and the matrix rotation flap. these procedures are employed to achieve both oncologic safety and aesthetic preservation in patients undergoing surgery for breast cancer. the primary objective of the study is to evaluate and compare the incidence and nature of postoperative complications associated with each technique. this includes, but is not limited to, wound healing issues, infection rates, hematoma or seroma formation, and any need for reoperation. secondary objectives focus on assessing the cosmetic outcomes and the overall satisfaction of the patients post-surgery. cosmetic evaluation will be conducted through both surgeon-assessed and patient-reported outcomes, utilizing standardized scoring systems and photographic documentation. patient satisfaction will be measured through validated questionnaires designed to capture perceptions of body image, aesthetic results, and quality of life following the procedure. by systematically analyzing these parameters, the study aims to determine which technique offers a more favorable balance of surgical safety, aesthetic quality, and patient satisfaction, thereby guiding clinical decision-making in breast-conserving surgery for breast carcinoma.

Eligibility criteria:
inclusion criteria: * upper quadrant breast carcinomas. exclusion criteria: * patients with t4 tumors, inflammatory breast cancer and distant metastasis, multi-centric breast cancer in more than one quadrant and diffuse microcalcifications were excluded from the study.

Keywords: breast cancer oncology mrf slim
a study of avastin (bevacizumab) in combination with chemotherapy in patients with previously untreated metastatic colorectal cancer.

Conditions: Colorectal Cancer

Summary: this single arm study will assess the efficacy and safety of a combination of modified folfiri (irinotecan, 5-fu and leucovirin), avastin and cetuximab in patients with previously untreated metastatic colorectal cancer. patients will receive modified folfiri (irinotecan 180mg/m2 iv, leucovirin 200mg/m2 iv, and 5-fu 400mg/m2 iv) on day 1 of each 2 week cycle, in combination with avastin (5mg/kg iv on day 1 of each cycle) and cetuximab (loading dose of 400mg/m2 followed by 250mg/m2 on day 3 of each cycle). the anticipated time on study treatment is until disease progression or unacceptable toxicity, and the target sample size is \<100 individuals.


Eligibility criteria:
inclusion criteria: * adult patients, \>=18 years of age; * colorectal cancer; * advanced or recurrent disease; * \>=1 measurable lesion; * \>=6 months since prior adjuvant therapy, and \>=4 weeks since prior radiotherapy. exclusion criteria: * previous treatment for colorectal cancer; * significant history of cardiac disease in past 6 months; * other invasive malignancy within past 5 years, except for nonmelanoma skin cancer, and successfully treated cervical or prostate cancer.
cooking for health

Conditions: Diabetes Mellitus, Type 2

Summary: type 2 diabetes is a leading cause of morbidity and mortality among american indians (ais) in the united states. although healthy diet is a key component of diabetes management programs, many ais face barriers to adopting a healthy diet including: difficulty budgeting for food on low-incomes, low literacy and numeracy when purchasing food, and limited cooking skills. the proposed project will evaluate a culturally-targeted healthy foods budgeting, purchasing, and cooking skills intervention aimed at improving the cardio-metabolic health of ais with type 2 diabetes who live in rural areas.

the research activities proposed in this application address a pressing need in american indian (ai) communities - the evaluation of a culturally-tailored healthy food budgeting, purchasing, and cooking intervention to see whether it can improve diet and health among ais with type 2 diabetes. this randomized clinical trial will compare the efficacy of a culturally-tailored healthy food budgeting, purchasing, and cooking program on: (1) diet quality (i.e., intake of sugar-sweetened beverages, processed foods) and (2) healthy food budgeting and cooking skills, among ais with type 2 diabetes who reside in a large ai community in the north-central united states. additionally, the investigators will conduct a mixed methods process evaluation to assess intervention reach, fidelity, and participant satisfaction. curriculum will be tailored to an ai population with diabetes, and directly address major barriers to healthy eating that were identified by community members and tribal leaders in recent focus groups including: (1) difficulty budgeting for food on low-incomes; (2) low literacy and numeracy when purchasing food (e.g., inability to use in-store scales to convert foods priced "per pound" to dollar values); (3) limited cooking skills. the investigators expect that implementation of a culturally-tailored diet intervention will be effective in promoting positive diet change, and increase healthy food budgeting and cooking skills. poorly controlled diabetes affects the health/longevity of those afflicted, and has profound effects on healthcare costs. greater efforts are needed to encourage healthy eating in underserved communities with a high burden of diabetes. improving healthy food budgeting, purchasing, and cooking skills among ais with diabetes should improve diet and diabetes management. if successful, this program can be extended to other ai communities.

Eligibility criteria:
inclusion criteria: * american indian * 18+ years * self-reported type 2 diabetes * reside on reservation where study is being conducted * self-identify as person who holds most of the responsibility for household budgeting, shopping, and cooking exclusion criteria: * pregnant * history of bariatric surgery * chronic kidney disease * on dialysis * cognitively impaired * individuals without a reliable place to cook or store food (e.g., homeless)

Keywords: diet cooking skills
maintenance treatment for children with constipation

Conditions: Constipation

Summary: constipation is a common problem among children. the majority of children suffering from constipation have no underlying disease. although constipation has no basis in underlying disease, it often leads to a reduced quality of life of children who are on par with or worse than for children suffering from serious diseases such as cardiovascular and rheumatic diseases. despite the high frequency of constipation among children, little is known about the causes and treatment of constipation. treatment consists of symptomatic treatment with various laxatives. movicol and movicol junior has proven very effective and are therefore widely used in children as disimpaction and maintenance treatment. there is currently no research to prove the need for and length of maintenance treatment with laxative medications in children. the purpose is to examining the effectiveness of maintenance treatment with movicol. additional til study will examine how the anal diameter change during a course of treatment and the degree to which it can be used as an indicator of treatment efficacy. the study will test the following: • what is the effect of maintenance treatment with peg compared to placebo? the results from this study are expected to form the basis for an evidence-based approach to the use of maintenance therapy and the use of ultrasound of the rectum in children with constipation.


Eligibility criteria:
inclusion criteria: * children between 2 and 16 years and referral to our out patient clinic with either constipation or fecal incontinence. * patients must fulfill the rome iii criteria of constipation, which mean they must have at least 2 of the following characteristics: fewer than 3 bowel movements weekly, more than 1 episode of fecal incontinence weekly, large stools in the rectum by digital rectal examination or palpable on abdominal examination, occasional passing of large stools, display of retentive posturing and withholding behavior, and painful defecation. exclusion criteria: * children with known organic causes of constipation, including hirsprung disease, spinal and anal congenital abnormalities, previous surgery on the colon, inflammatory bowel disease, allergy and metabolic or endocrine diseases. * children receiving drugs known to affect bowel function during a 2 month period before initiation. * the healthy control group consists of children with no history of constipation (rome iii), urinary incontinence, urinary tract infections, fecal incontinence, laxative use or any other disease affecting the digestive system. * children receiving medications known to affect bowel function are excluded from the study.

Keywords: constipation maintenance treatment ultrasound of rectum
communicating veins between adjacent hepatic veins: an intra-operative ultrasound study

Conditions: Liver Tumors

Summary: the search for communicating veins (cvs) between adjacent hepatic veins (hvs) has drawn its rationale from living donor liver transplantation (ldlt). parenchymal sparing procedures although hvs are resected suggest that probably their presence is underestimated. taking profit from new improvements in ultrasound technology the investigators aim to better estimate the rate of cvs in a consecutive series of patients in whom resection of one hv at caval confluence is needed.

the search for communicating veins (cvs) between adjacent hepatic veins (hvs) has drawn its rationale from the need of reducing the risk of incomplete blood outflow in the medial portion of the hemiliver without the middle hepatic vein (mhv) in living donor liver transplantation (ldlt). however, only 24% of patients seems having cvs based on the findings of color-doppler intraoperative ultrasound (cd-ious) exploration. on the other hand the safety of parenchymal sparing procedure despite hv resection let suppose that cvs are probably more frequent than expected. certainly, better in vivo knowledge of the rate of cvs and their direct detection would consolidate and probably further expand parenchymal sparing techniques. taking profit from new advancements in ultrasound technology we have carried out the present study with the aim of better estimating the rate of cvs in a consecutive series of patients in whom resection of one hv at caval confluence was needed.

Eligibility criteria:
inclusion criteria: * patients suitable for being enrolled in the present study were those carriers of primary or metastatic tumour with direct contact or invasion of one hv at the caval confluence. exclusion criteria: * n/a

Keywords: communicating veins hepatic venous anastomosis intra-operative ultrasonography hepatic resection hepatic neoplasm primary and metastatic liver tumors
identification of pre-malignant lesions in pediatric patients with neurofibromatosis type 1 using novel magnetic resonance imaging techniques paired with artificial intelligence

Conditions: Neurofibromatosis Type 1

Summary: this is a single arm pilot trial of a novel whole-body magnetic resonance imaging paired with artificial intelligence intervention, to evaluate feasibility defined as scan-rescan reliability, and to estimate the positive predictive value of changes in magnetic resonance imaging scans from baseline to 12-month visit using an artificial intelligence algorithm, among 15 pediatric patients with neurofibromatosis type 1 at cedars-sinai medical center.


Eligibility criteria:
inclusion criteria: * between the ages of 5 and \<18 years at the start of study. if subject will turn 18 during the study, they will be allowed to enroll. * clinically or molecularly confirmed diagnosis of nf-1. subjects with mosaic/segmental nf-1 also qualify for the study. exclusion criteria: * requiring sedation for imaging. * implants and/or devices: mechanical, magnetic or electrical activated implants; ferromagnetic implants and foreign bodies * claustrophobia, problems being in enclosed spaces, or inability to lie facing upwards. * allergy to animal dander or animal-instigated asthma.

Keywords: pediatric neurofibromatosis type 1 magnetic resonance imaging
medical evaluation of scanner in coronary syndrome

Conditions: Coronary Syndrome

Summary: many recent publications have reported encouraging results on diagnostic cardiac multislice ct performance in 1) coronary artery disease, 2) coronary arterial bypass graft potency and 3) intrastent restenosis. these single center studies were made on a limited number of patients (range, 50-130) and focused mainly on one of the indications mentioned above. moreover, results were often given after exclusion of low quality examinations. at last, no study has compared the diagnostic performance of the different ct systems '16, 40 and 64) in these populations.

these single center studies were made on a limited number of patients (range, 50-130) and focused mainly on one of the indications mentioned above. moreover, results were often given after exclusion of low quality examinations. at last, no study has compared the diagnostic performance of the different ct systems '16, 40 and 64) in these populations.

Eligibility criteria:
inclusion criteria: * patients' ≥18 years, of both sexes * coronary angiography in patients with suspected of known cad, instable clinical conditions. * clinical status allowing performance of coronary angiography 48 à 72h after ct examination * informed consent signed by patient exclusion criteria: * patients in whom clinical status does not allow delayed coronary angiography * irregular heart rate, in particular atrial fibrillation * renal insufficiency (serum creatinine \>150 µmol/l * radiology examination with use of iodin agent with 48h before) ct coronary * k now intolerance to iodin agents * patients unable to hold breathing \< 20 seconds * pregnancy

Keywords: stenosis coronaropathy stent bypass surgery suspect known
cranberry for the prevention of urinary tract infections

Conditions: Urinary Tract Infection

Summary: this study aims to determine whether a cranberry concentrate reduces recurrent urinary tract infections (utis) in women. approximately 150 adult women will be recruited to participate in this study. subjects will be randomized to either the cranberry supplement or placebo treatment for 12 months. subjects and investigators will be blinded to which supplement they are taking.

participants will be randomized to receive either a cranberry concentrate or placebo. participants, study staff and investigators will remain blinded until after the dataset has been cleaned. at the baseline visit participants will be instructed to consume the assigned supplement twice daily for 12 consecutive months. a calendar will be provided to record compliance, recurrent utis and any side effects. participants will be phoned/texted each month to encourage participation. additional study visits will be completed at 3 months, 6 months and 9 months to collect information on recurrent utis and adherence. a urine sample will be collected from participants at each visit to test for pregnancy and the presence of an undetected uti. supplements will be distributed at each visit for the following 3-month study period and the last bottle of unused product returned. at the 12-month visit, participants will complete an end-line questionnaire and return their supplement bottle in addition to the calendar and side effect diary. if participants withdraw from the study, they will be encouraged to return at 12 months to complete a survey to allow for intent-to-treat analysis.

Eligibility criteria:
inclusion criteria: * females who have had at least 2 clinical-diagnosed symptomatic utis in the year preceding * can communicate in english exclusion criteria: * current uti * pregnant or breastfeeding or planning a pregnancy in the next 12 months * known allergy or intolerance to cranberry-containing products * a history of renal stones and/or renal transplantation * any immunosuppressive disease or other medical conditions that could potentially interfere with outcomes * current use of corticosteroid, anticoagulant, antidepressants or mood stabilizing medications or other medications that may interact with the supplement * intermittent or indwelling catheterization * any anatomic abnormalities of the urinary tract * the use of any antibiotics within 2 weeks before study entry * the use of any natural health products, including herbs, homeopathic products, or other forms of cranberry supplements within 2 weeks before study entry