Kornimate/medical-research-clean huggingface dataset:
drug releasing ball vs. pharmacoactive stent in large vessels: morphological analysis and function vasomotor (debora study) in large vessels: morphological analysis and function vasomotor (debora study)

Conditions: Coronary Artery Disease

Summary: randomized, controlled, open and multicenter study that analyzes the vasomotor function 8 months after use of the drug-eluting balloon (dcb) vs. drug-eluting stent (des) in vessels ≥ 3.5 mm

randomized, controlled, open and multicenter study that analyzes the vasomotor function 8 months after use of the drug-eluting balloon (dcb) vs. drug-eluting stent (des) in vessels ≥ 3.5 mm

Eligibility criteria:
inclusion criteria: patients who meet all of the following conditions are included. * patients aged ≥ 18 years and; * patients with chronic coronary syndrome, acute coronary syndrome without st segment elevation or acute coronary syndrome with elevation st segment in non-culprit lesions 48 hours after the event and; * patients with de novo lesions in vessels ≥ 3.5 mm without calcification significant no visible thrombus and; * patients who have been informed of the characteristics of the study and have provided their written informed consent. exclusion criteria: patients who meet at least one of the following conditions are excluded: * patients with any contraindication for the administration of acetylcholine (ach) or nitroglycerin (ntg). * patients with a history of coronary vasospasm or spontaneous dissection of the coronary artery. * patients with significant medical, surgical or psychiatric condition that would affect the safety of the subject or influence the outcome of the study according to the doctor's opinion. * patients who received a combination of des and dcb in the same vessel * patients with glomerular filtration rate \<30 ml/min/ 1.73 m2 * patients with body mass index \>35 (may affect the evaluation qualitative diameter of the coronary artery). * patients with symptomatic congestive heart failure. * patients with significant autoimmune inflammatory conditions and patients taking immunomodulatory medications (including methotrexate, cyclosporine, steroids). * patients with heart transplant. * patients with anemia (hb \<12 g/dl in men and \<10 g/dl in women). * patients, women of childbearing age with a positive pregnancy test. * pregnant female patients. * patients included in other clinical trials with active follow-up.

Keywords: drug-coated balloon vasomotor function
efficacy of ivermectin in outpatients with non-severe covid-19

Conditions: Covid19; Coronavirus Infection

Summary: this is a randomized controlled trial to evaluate the efficacy of ivermectin in reducing the risk of progression to severe disease and hospitalizations in covid-19 patients.

this is a randomized controlled trial to evaluate the efficacy of ivermectin in covid-19 outpatients reducing the risk of progression to severe disease. patients with covid-19 infection are randomized to receive a single dose of 200mcg/kg of ivermectin or a placebo. the randomization code is generated by the trial statistician. the allocation is made after fulfilment of both inclusion and exclusion criteria.

Eligibility criteria:
inclusion criteria: * positive diagnostic rt-qpcr or antigen test for sars-cov-2 * symptomatic patients with up to 8 days from the onset of symptoms, and asymptomatic cases with up to 5 days of positive test for sars-cov-2. * patients who agree to participate in the study by signing the informed consent. exclusion criteria: * patients with severity criteria defined in the coronavirus disease epidemiological and laboratory surveillance guide (version 3/11/2020) * pregnant or breastfeeding women * women of childbearing age and without commitment to use contraceptive methods during the study time. * inability to complete the study * current treatment with drugs known to interact with ivermectin * known intolerance to ivermectin, its derivate or any of its excipients. * patients with known child-pugh c liver disease * patients with prior ivermectin consumption in the 10 days prior to study entry.

Keywords: ivermectin communicable diseases respiratory tract infections
demographics, diagnosis, management, and outcomes of non-occlusive mesenteric ischemia.

Conditions: Non-Occlusive Mesenteric Ischemia

Summary: this prospective multicenter observational study, conducted between june , 2022, and april, 2023, is a preplanned analysis of the amesi study titled 'demographics, diagnosis, management, and outcomes of non-occlusive mesenteric ischemia,' aiming primarily to describe the demographic profile, clinical presentation, and laboratory findings of patients with non-occlusive mesenteric ischemia (nomi), and secondarily to identify independent risk factors as well as diagnostic approaches, management strategies, and outcomes-including in-hospital, 90-day, and one-year results.


Eligibility criteria:
inclusion criteria: all at least 18-year-old patients with acute mesenteric ischemia or patients suspected of acute mesenteric ischemia that was not confirmed * patients with arterial occlusive ami * patients with non-occlusive mesenteric ischemia * patients with venous occlusive ami * patients with unclear mechanism of ami * patients with suspected but not confirmed ami exclusion criteria: * patients with other specific form of ami (e.g dissection) * confirmed strangulating bowel obstruction * individuals under 18 years of age. * consent declined by patient or next of kin * chronic mesenteric ischaemia without an acute event
resistance to antithrombotic therapy

Conditions: Atherosclerosis; Angioplasty

Summary: clopidogrel plays a pivotal role in the antithrombotic regimen after percutaneous intervention with stent implantation. however, response to clopidogrel shows a wide interindividual variability and a high on-treatment residual adp-inducible platelet reactivity has already been associated with an increased risk for adverse events after coronary stenting. in the present study, platelet reactivity will be determined by 6 different platelet function tests in patients on dual antiplatelet therapy after angioplasty and stenting for peripheral, coronary and carotid artery disease. one hundred patients showing high on-treatment residual adp-inducible platelet reactivity in 2 or more tests will be randomized to receive either 75mg or 150mg of daily clopidogrel in addition to aspirin for 3 months. the aim of the present study is to investigate the effects of intensified antithrombotic therapy (150mg clopidogrel + 100mg aspirin daily) versus standard antithrombotic therapy (75mg clopidogrel + 100mg aspirin daily) in patients with decreased clopidogrel-mediated platelet inhibition after percutaneous intervention with stent implantation.


Eligibility criteria:
inclusion criteria: * written informed consent * angioplasty and stenting for peripheral, coronary or carotid artery disease exclusion criteria: * known aspirin or clopidogrel intolerance * therapy with vitamin k antagonists (warfarin, phenprocoumon, acenocoumarol) * treatment with ticlopidine, dipyridamol or nonsteroidal antiinflammatory drugs * family or personal history of bleeding disorders * malignant paraproteinemias * myeloproliferative disorders * heparin-induced thrombocytopenia * severe hepatic failure * known qualitative defects in thrombocyte function * major surgical procedure within one week before enrollment * platelet count \ 450.000/µl * hemoglobin \< 8 g/dl

Keywords: clopidogrel aspirin antithrombotic therapy platelet function testing
extension of rapid response team operation time and cardiopulmonary resuscitation incidence

Conditions: Cardiopulmonary Arrest

Summary: although early rapid response team was reported as a full-time operating system, similar efficacy of part-time rapid response team has been recently reported. we sought to investigate the association between the duration of rapid response team operation time and the incidence of general ward cardiopulmonary resuscitation.

rapid response team (rrt) was introduced to reduce the preventable cardiac arrest in general wards and it has been spread worldwide. rrts usually consist of dedicated intensivists in rrt and nurse specialists in critical care. although rrt implementation could useful, it is not suitable for all hospital circumstances because it is required high cost and plenty of experience in critical care settings. for this reason, to minimize the rrt operating cost, the part-time rrt operation was reported. recently similar efficacy in part-time operation rrt was reported. however, it is difficult to compare full-time and part-time rrt and no study has been reported the efficacy according to the intensity of rrt operation time. authors invested the incidence of general ward cardiopulmonary resuscitation according to the rrt operation time; from the initial implementation to the full-time rrt operation after stepwise extension.

Eligibility criteria:
inclusion criteria: * patients admitted to study hospital from april 1, 2014, to december 31, 2020 exclusion criteria: 1. patients who developed cpr in elsewhere not gw (icu, emergency department, operation room, outpatient clinics, cardiac catheterization laboratory) 2. younger than 18 years 3. patients admitted via the emergency department

Keywords: cardiopulmonary arrest rapid response team operation time
restorelle® mesh versus native tissue repair for prolapse

Conditions: Pelvic Organ Prolapse

Summary: the purpose of this study is to collect information on the safety and effectiveness of restorelle direct fix mesh and the surgical procedure to implant restorelle. these results will be compared to the safety and effectiveness results in patients who have native tissue repair (without mesh) as their pelvic organ prolapse treatment.


Eligibility criteria:
inclusion criteria: * female at least 18 years of age * subject has pelvic organ prolapse with leading edge at or beyond the hymen. at or beyond the hymen is defined as pop-q scores of ba ≥0 and c≥ -1/2 tvl or bp ≥0 and c≥ -1/2 tvl * subject reports a bothersome bulge they can see or feel per pfdi-20 question 3, response of 2 or higher (i.e. responses of "somewhat", "moderately" or "quite a bit") * subject is willing to provide written informed consent * subject is willing and able to comply with the follow-up regimen exclusion criteria: * subject is pregnant or intends to become pregnant during the study * subject has an active or chronic systemic infection including any gynecologic infection, untreated urinary tract infection (uti), or tissue necrosis * subject has a history of pelvic organ cancer (e.g. uterine, ovarian, bladder, or cervical) * subject has had prior or is currently undergoing radiation, laser therapy, or chemotherapy in the pelvic area * subject has taken systemic steroids (within the last month), or immunosuppressive or immunomodulatory treatment (within the last 3 months) * subject has a systemic connective tissue disease (e.g. scleroderma, systemic lupus erythematosus (sle), marfan syndrome, ehlers danlos, collagenosis, polymyositis or polymyalgia rheumatica) * subject has chronic systemic pain that includes the pelvic area or chronic focal pain that involves the pelvis * subject has uncontrolled diabetes mellitus (dm) * subject has a known neurologic or medical condition affecting bladder function (e.g. multiple sclerosis, spinal cord injury, or stroke with residual neurologic deficit) * subject is seeking obliterative vaginal surgery as treatment for pelvic organ prolapse (colpocleisis) * subject is not able to conform to the modified dorsal lithotomy position * subject is currently participating in or plans to participate in another device or drug study during this study * subject has a known sensitivity to polypropylene * subject has had previous prolapse repair with mesh in the target compartment(s) * subject is planning to undergo a concomitant prolapse repair in a non-target compartment with anything other than native tissue repair

Keywords: pelvic floor disorder pelvic organ prolapse sexual dysfunction mesh pop transvaginal anterior posterior apical uterine prolapse cystocele rectocele enterocele vaginal vault prolapse native tissue repair repair augmented with mesh pathological conditions, anatomical restorelle direct fix vaginal mesh transvaginal mesh
development and testing of a patient-facing educational tool about liver cancer prevention

Conditions: Liver Cancer

Summary: to develop and test liver cancer prevention educational material.

primary objectives: * to ensure the text for the site is understood by participants, participant comprehension will be measured qualitatively through cognitive testing. adjustments will be made to the content, messages, and layout iteratively until interviewer notes show no large discrepancies between participant understanding and the meaning of the text. * to ensure the site is easy to use, usability will be measured qualitatively through usability testing. adjustments will be made to the functionality of the patient-facing portions of the web-based tool iteratively until interviewer notes indicate that participants are able to input their risk factors and download the personal summary on their own. secondary objectives: * to describe whether the site is acceptable to users, acceptability will be measured (as part of usability testing) with the ottawa acceptability measures. * to describe participants' knowledge of liver cancer risk factors, knowledge will be measured (as part of usability testing) with knowledge questions developed for this study.

Eligibility criteria:
inclusion criteria: * at least 18 years old * participants at the hope clinic * able to speak and read either english or spanish * for usability testing: able to use and navigate websites on own smart phone or study computer exclusion criteria: * has been diagnosed with liver cancer * cannot provide consent or otherwise participate in research activities (e.g. vision or hearing impairment)

Keywords: liver cancer liver disease fibrosis cirrhosis
home-based vs intradialysis exercise guided by nursing staff

Conditions: End Stage Renal Disease on Dialysis

Summary: participants will be randomized either to home-based exercise or to intradialysis exercise guided by nurses of the renal unit. the programs will last 16 weeks. the intradialysis exercise consists of combined aerobic and resistance training exercise. the home-based exercise consists of resistance exercise and walking.

during 16 weeks one group will follow an intradialysis exercise program. the exercise program consists of strengthening exercises for lower limbs and for the upper limb free of fistula. the exercise program includes isotonic exercises for quadriceps, triceps surae, psoas, glutei, and brachial biceps; and isometric exercises for hip adductors and hamstrings. elastic bands will be used to apply resistance. progression will be achieved by increasing from 1 set of 10 repetitions until 3 sets of 15 repetitions. this first part of the exercise session will last no more than 30 minutes. the program will also include aerobic exercise (cycling) for up to 30 minutes. intensity will adapted through the duration of the study so that the participant feel the exercise from hard to somewhat hard (13 to 15 at the rate of perceived exertion 6 to 20). time and resistance will be adapted progressively. after an initial training period by a physiotherapist, the nursing staff will be responsible for monitoring and implementing the program. the other group will follow a home-based program. a booklet with resistance exercise and recommendation of walking between exercises will be provided. an initial training phase will be applied by the physiotherapists from the rehabilitation department.

Eligibility criteria:
inclusion criteria: patients on hemodialysis medically stable, be able to walk at least a few steps, even if you need walking aids like canes or a walker. life expectancy greater than 6 months exclusion criteria: 1. myocardial infarction in the previous 6 weeks 2. angina unstable on exercise or at rest 3. brain injury derived from a cardiovascular problem. cerebral vascular disease such as stroke in the last 6 months or with relevant sequelae in lower limb mobility presenting hemiparesia. 4. life expectancy less than 6 months 5. cognitive impairment 6. language barriers 7. illiteracy

Keywords: exercise hemodialysis
decreasing chemotherapy induced distress using immersive virtual reality in patients with cancer

Conditions: Malignant Neoplasm; Cancer

Summary: the goal of this clinical trial is to learn if the use of virtual reality during chemotherapy treatment helps participants achieve an improvement in distress, which may include unpleasant experience, anxiety, depression and/or pain. participants will: * be randomly assigned to one of two available groups (virtual reality or standard of care) * participations will only be during one chemotherapy session. * those assigned to virtual reality: * the research team will provide a virtual reality * the research team will provide guidance on how the headset works and will be available to assist with any questions or concerns. * participants will also be able to choose different relaxing backgrounds depending on their preference. headset during the chemotherapy session for 15 to 30 minutes * those assigned to the standard of care: * the research team will provide the participants with the opportunity to choose a preferred activity such as reading a book, watching television, etc.

in recent decades, new cancer cases have consistently risen. participants diagnosed with cancer commonly face psychological symptoms including distress, anxiety, and depression in addition to physical symptoms (i.e., pain). importantly, these symptoms might be exacerbated during chemotherapy sessions. new innovative technological strategies have been under development to control the symptoms and improve quality of life. immersive virtual reality (vr) is a simulated experience that enables participants to interact with an artificial three-dimensional visual and auditory environment. vr could be an innovative intervention to relieve psychological symptoms associated with chemotherapy.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years. * biopsy proven diagnosis of cancer (any stage or type). * must have a national comprehensive cancer network distress thermometer score ≥ 5 any time since diagnosis. * must have the ability to understand and the willingness to sign a written informed consent document * followed by a medical oncologist, radiation oncologist, and/or breast surgeon at cleveland clinic. * ability to read and write in english or spanish. exclusion criteria: * age \<18 years. * no prior history of cancer. * prior medical history of severe motion sickness. * prior medical history of seizures * pregnancy. * unable or unwilling to participate in the immersive virtual reality study at the maroone cancer center

Keywords: virtual reality chemotherapy
efficacy of an smartphone app intervention based on self-compassion for mental health among university students

Conditions: Mental Health Issue

Summary: since the beginning of covid-19, there has been an increase in the incidence of mental disorders and psychopathological symptoms, such as depression, anxiety and stress, among university students. even with the end of social distancing, many students still have losses in emotional well-being, so psychotherapeutic interventions are important for the recovery and promotion of the mental health of this public. interventions based on self-compassion have been associated with improving the mental health of different audiences, either by reducing psychopathological symptoms (such as anxiety) or improving positive constructs associated with mental health, such as hope and optimism. one way to administer interventions based on self-compassion is through mhealth technologies, which have been consolidating since the pandemic. some studies sought to assess the benefits of self-compassion-based interventions administered in the mhealth format among university students suggest that they have acceptability and are effective regarding indicators of emotional well-being. however, in brazil, there is still no digital intervention for the cultivation of self-compassion among university students, which could help to mitigate the deleterious effects of the pandemic on mental health. considering this gap, an intervention based on self-compassion administered via a smartphone app called "eu + compassivo" was developed. the present study seeks to evaluate its efficacy in mental health indicators, both psychopathological symptoms and positive psychology constructs.


Eligibility criteria:
inclusion criteria: * must be enrolled in a course that originally works in the face-to-face format * having basic knowledge of the use of smartphones * owning a smartphone with internet access and the android or ios system * at least mild depressive, anxiety or stress symptoms exclusion criteria • diagnosed with any serious and persistent mental disorder
effects of kendall exercise versus gong's mobilization in text neck syndrome. a pilot study

Conditions: Neck Pain

Summary: this project was a pilot randomized trial conducted to compare the effects of kendall exercise and gong's mobilization on pain, range of motion, function and strength in text neck syndrome so that we can have best treatment option for patients with neck pain

non probability convenient sampling was done. patients following eligibility criteria from fatima hospital sargodha were considered. sample size was calculated 12. participants were randomly allocated in two groups equally via convenient sampling method. baseline assessment was done initially. group a was given kendall exercise and group b was given gong's mobilization along with conventional physiotherapy treatment (hot pack). duration of research was almost 6 months. participants were treated 3 times a week for 4 weeks. pre and post treatment readings were taken in 1st session and 4th week period respectively. assessment was done via numeric pain rating scale (nprs),neck disability index (ndi), universal goniometer and modified sphygmomanometer test. all participants were provided written informed consent prior to commencement of the procedures. they were free to quit the treatment at any stage of research. data was analyzed by using spss version 23.

Eligibility criteria:
inclusion criteria: * young adults * more than one year using a smartphone * using smart phone for more than 2 hours a day * craniovertebral angle(cva)less than 53° * score of more than 3 on nprs and more than 10 on ndi exclusion criteria: * spinal infection or inflammatory disorder * neck surgery or trauma * torticollis, scoliosis * malignancy, pregnancy * diagnosed cases of disc prolapse, stenosis, herniation, spondylolisthesis and osteoporosis * current use of any medication or physical therapy treatment.

Keywords: neck pain