Kornimate/medical-research-clean huggingface dataset:
effect of music on emergence delirium

Conditions: Emergence Delirium

Summary: the researchers are conducting a research study to see whether listening to music during an operation will have a positive effect on the way that children wake up from surgery/anaesthetic. it is a common phenomenon where children wake up unhappy, irritated and screaming (known as emergence delirium). research have shown that music decreases anxiety and pain. the researchers want to see whether music can also influence a child's behaviour after emerging from anaesthesia. in other words whether they will be more calm and cooperative after listening to music while they are asleep during surgery. should music have a positive effect, anaesthesiologists may use it in future to improve care of patients coming for surgery.

children coming for certain elective surgeries, where pain has been excluded as a confounding factor, will have headphones placed on their ears after induction of anaesthesia. they will be randomised to two groups, one will receive music and the other just silence. the headphones will be removed just before waking the patient up. in the recovery room the child's behaviour will be observed and will be scored according to a validated score. the two groups will then be compared to see whether music makes a difference to the behaviour after anaesthesia.

Eligibility criteria:
inclusion criteria: * ages 2-7 years * american society of anaesthesiologists class i and ii patients * child has adequate hearing * surgery or procedure under general anaesthesia * receiving standardised anaesthetic * type of surgeries included: orthopaedic, urological, paediatric surgery and ophthalmology * minimum exposure to music must be 15minutes * child may not receive any premedication exclusion criteria: * american society of anaesthesiologists class 3 and above * emergency cases * children with hearing problems * cognitive impairment
characterization of long covid pain in primary care

Conditions: Long COVID; Chronic Pain; Musculoskeletal Pain

Summary: justification: among the sequelae of covid-19 in clinical practice we frequently find persistent neuromusculoskeletal pain. prevalence data and the underlying mechanisms of such pain are very limited in the scientific literature. therefore, with this research we will try to answer these questions. main objective: to determine and characterize persistent musculoskeletal pain in covid-19 patients. method: two phases. first, a descriptive cross-sectional study will be carried out to estimate the prevalence of long covid pain (lcp). second phase, a case-control study will be carried out using the sample obtained in the first phase as the population. the sample will be divided into two groups: post-covid-19 patients with lcp and post-covid-19 patients without persistent pain (control group). the two groups will be matched according to sex, age and level of severity of the pathology. an assessment and comparison between groups will be made of the following variables: central sensitization, healthy physical condition and blood test values, which will be evaluated by means of physical examination, questionnaires and laboratory tests. applicability of the results: this is a pioneering project at the national level, which would determine more reliably the prevalence of lcp in postcovid and could be a first step in the search for the best therapeutic strategies for these patients. this would help to improve the quality of life of these patients and to better manage the social and healthcare resources used in their treatment.


Eligibility criteria:
inclusion criteria: * patients who have had covid-19, with a confirmatory pcr+ test or positive antigen test and recorded in their primary care medical record. * subjects between 18-70 years old. * musculoskeletal pain of more than 12 weeks of evolution since the beginning of the infection. * agree to participate in the study and sign the informed consent form. exclusion criteria: * history of chronic musculoskeletal pain of more than 12 weeks of evolution prior to covid-19. * history of diagnosed major depression. * having a diagnosis of fibromyalgia prior to covid-19 infection. * pregnancy. * pain of oncologic origin. * fracture or surgical intervention on the spine in the last year. * bladder or bowel incontinence. * saddle anesthesia.

Keywords: long covid chronic pain musculoskeletal pain primary health care psychological factors
effectiveness of a novel neural tissue management to improve short-term pain and disability in patients with sciatica

Conditions: Sciatica Pain; Physical Therapy Modalities; Manual Therapies; Disability Evaluation

Summary: objectives: to analyse the effects of sciatic neural mobilisation, in combination to the treatment of the surrounding structures, on pain and disability. secondly, to investigate baseline characteristics that may be associated with improvements in pain and lumbar disability. methods: twenty-eight patients with a clinical diagnosis of sciatica were treated with neural mobilization, joint mobilisation and soft tissue techniques. pain intensity and lumbar disability were assessed at baseline and after treatment using a numerical rating scale (0-10) and the oswestry disability index (0-100), respectively. the pre- and post-intervention data were compared.


Eligibility criteria:
inclusion criteria: * low back pain with radiating leg pain and/or paresthesia below the knee that follows the l5 and/or s1 dermatomal pattern. exclusion criteria: * history of lumbar and abdominal surgery * rheumatologic syndromes (e.g. rheumatoid arthritis); * lumbar stenosis.

Keywords: lumbosacral plexus physical therapy modalities manual therapies disability evaluation.
cardiopulmonary rehabilitation in chronic stroke

Conditions: Stroke; Hemiplegia

Summary: this study is aimed to determine the effects of an accompanying structured cardiopulmonary rehabilitation program along with a neurorehabilitation program on the quality of life, care-giver burden and overall well-being of the patients.


Eligibility criteria:
inclusion criteria: * a history of ischemic stroke at least 6 months ago exclusion criteria: * any cardiac or pulmonary problem that renders the patient unavailable for the program * mental impairment * not being able to perform exercise testing * not being able to walk independently
prospective study of antiplatelet and anticoagulation therapy in hereditary haemorrhagic telangiectasia

Conditions: Hereditary Hemorrhagic Telangiectasia; Rendu Osler Disease

Summary: the goal of this clinical trial is to evaluate in real life, in patients with hereditary hemorrhagic telangiectasia (hht), the tolerance of the strategy of use of anticoagulant and/or antiplatelet, by comparing a new exposure period (first trimester of treatment) to a period of reference non-exposure (last trimester before start of treatment).

currently there are no recommendations on the use of anticoagulant and/or antiplatelet treatment in patients with rendu-osler disease. the main question this study aims to answer is: • to better determine which anticoagulant and/or antiplatelet therapy are best tolerated or if they are equivalent in rendu-osler disease because this type of treatment is often used in urgent and/or vital situations. participants will have a 2-year follow-up with biological monitoring of ferritin and hemoglobin level and ess (epistaxis severity score) and qol-hht (quality of life hereditary hemorrhagic telangiectasia) questionnaires.

Eligibility criteria:
inclusion criteria: * patient with rendu-osler disease with an indication of antiplatelet and/or anticoagulant introduced for less than 3 months (inclusion period within 3 months of exposure) * age \> 18 years old * patient able to understand and agree to participate in the study * affiliation to a social security system exclusion criteria: * patient with an indication of antiplatelet and/or anticoagulant but for whom treatment has not been introduced or introduced for more than 3 months * refusal to participate * pregnant woman or who are breast feeding * patients under maintenance of justice, wardship or legal guardianship

Keywords: epistaxis hemorrhage anticoagulant therapy antiplatelet therapy
fluoride application on preventing and arresting root caries in fluoridated and non-fluoridated areas

Conditions: Dental Caries

Summary: this study was a randomized clinical trial lasting for 24 months in two study sites, hong kong (water fluoridated) and guangzhou (non-fluoridated area). a total of 534 subjects will be recruited from elderly social centers located in different districts in the two study sites (260 \& 274). baseline clinical examination was conducted by a single calibrated examiner in the social centers using an intra-oral led light, mouth mirrors and probes. subjects were randomly allocated into two study groups and receive interventions accordingly. follow-up examinations at 6-month intervals were carried out to assess the clinical outcomes, i.e. whether new root caries developed and whether the active root caries found at baseline become arrested. results of this study could provide the much needed evidence to guide the dental professionals in hong kong and china, and possibly worldwide in deciding on the most appropriate intervention for the prevention and management of this common dental disease of the older adults.

the primary and secondary outcome of this study was new root caries and arrested root caries. a root surface with new caries experience was recorded when a root surface which was sound at baseline was found to have a carious lesion or a filling at a follow-up examination. arrested root caries was recorded when the active root caries found at baseline changed into inactive root caries at follow-up. the status of each root surface was recorded using the codes recommended by the international caries detection and assessment system (icdas ⅱ) coordinating committee in 2009. a mean root caries increment of around 0.8 root surface per year of control group was reported in a previous clinical trial conducted in hong kong. thus, in this study, a 24-month increment of 1.6 new decayed root surfaces and a standard deviation of 2 was anticipated. in order to show that a 50% difference in mean caries increment between the test and control groups was statistically significant using a 2-sample t-test at a 5% significance level and at an 80% power, a sample size of 100 subjects in each group was required. allowing for a drop-out rate of 20% over 24 months, a total of 480 subjects (120 in each group each site) were needed.

Eligibility criteria:
inclusion criteria: 1. have at least 5 teeth with exposed root surfaces and not indicated for extraction, and 2. living in the community and have self-care ability for normal daily activities. exclusion criteria: 1. have life-threatening or serious health problems, 2. have cognitive problems in communication or in receiving oral hygiene instructions 3. have salivary gland diseases or received radiotherapy in the head and neck region.
evolution of food orality in children aged between 24 and 36 months: comparison of the severity and specificities of disorders between two populations of children, born very prematurely and born at term

Conditions: Infant, Premature, Diseases

Summary: oral disorders are currently widely described in the premature birth population, but few studies compare them to their prevalence in the full-term population. in addition, new behaviours and eating habits are regularly emerging in our society. the objective of this study is to compare the severity of signs of oral disorders between the group of preterm infants and the group of term infants born without organic pathologies that compromise oral development.


Eligibility criteria:
inclusion criteria: * children whose age ≥ 24 months and ≤ 36 months * full-term or prematurely born (\<33 sa) at nice university hospital exclusion criteria: * children with congenital pathologies (with malformations in the oro-facial sphere) * children with neurological and developmental pathologies unrelated to prematurity * children with ent deformities * parental langage barrier
comparison of a cemented, polished tapered stem and an anatomic stem for femoral neck fracture

Conditions: Hip Fracture; Femoral Neck Fracture; Periprosthetic Femoral Fracture

Summary: postoperative periprosthetic femoral fracture after hip arthroplasty is associated with considerable morbidity and mortality. recent cohort studies have demonstrated a high incidence of ppf in elderly patients treated with two commonly used polished, tapered, collarless stems in elderly patients. the aim of this study was to compare the rate and characteristics of ppf in a consecutive cohort of patients treated either the polished tapered ctp stem or the matte anatomic sp2 stem in an elderly population above 80 years of age with femoral neck fracture.


Eligibility criteria:
inclusion criteria: * displaced femoral neck fracture * treated with a primary hip arthroplasty exclusion criteria: * secondary arthroplasty due to sequel after femoral fracture

Keywords: femoral neck fracture hip arthroplasty complication periprosthetic femoral fracture
arthroscopic rotator cuff repair with synovectomy

Conditions: Rotator Cuff Tears

Summary: the purpose of this study is to assess the effect of synovectomy on clinical outcomes of arthroscopic rotator cuff repair.


Eligibility criteria:
inclusion criteria: - patients with a full-thickness rotator cuff tear undergoing arthroscopic rotator cuff repair exclusion criteria: * history of shoulder surgery * acute trauma on affected shoulder * chronic dislocation * pyogenic infection * rotator cuff arthropathy with glenohumeral osteoarthritis and superior migration of the humeral head * isolated subscapularis tear * psychiatric problems that precluded informed consent * an inability to read or write * other serious issues that precluded participation in the study * open surgery * rotator cuff tear with worker's compensation claim * refuse to participate in the study * lom that need brisement force * partial-thickness tear with focal full-thickness extension * irrepairable rotator cuff tear * subjects who, for any reason, are judged by the investigator to be inappropriate for this study, including a subject who had other severe medical condition or laboratory abnormality, or who is unable to communicate or to cooperate with the investigator
to compare the triple drug therapy and dual therapy .

Conditions: HEPATITIS

Summary: study to compare the safety and efficacy of tacrolimus and steroids in combination with mycophenolate mofetil or without mycophenolate mofetil in liver transplantation with hepatitis b virus(hbsag) positive


Eligibility criteria:
inclusion criteria: * men or women at the age of 20 to 65 * patients who will have primary liver transplantation becaused of chronic hepatitis b of hbsag positive * having confirmed a result of hbsag positive patients within 6 months prior to screening point. * patients who will have liver transplantation from abo-compatible or proper living donor ⑤ patients who will receive investigational products for the entire period of clinical trial. * patients who have signed the informed consent after understanding of clinical trial's purpose and risk. * for women of childbearing potential, pregnancy test negative from urine or blood and women who agree to contraception for the entire period of clinical trial. exclusion criteria: * recipients who had liver transplantation or who had or will have other organ transplantation * recipients who other organ transplantation in addition to liver at once. * recipients who will have auxiliary partial orthotopic liver transplantation. * recipients who use a bioartificial liver prior to transplantation * cr \> 2.0mg/dl at screening test * patients who had malignant tumor within the past 5 years or have malignant tumor(except, successfully treated skin's non-metastatic basal cell carcinoma, squamous cell carcinoma or primary hepatocellular carcinoma ) * recipients had hepatocellular carcinoma whick is out of milan criteria * wbc\<1,500/mm3 or anc\<900/mm3 or plt\<30,000/mm3 at screening * investigator judge that a patient is not proper to enroll this study due to severe digestive disorder at screening * patients who have severe systemic infection (but the liver transplantation is excepted that performed after the infection is completely lost or well-controlled) ⑪ recipients who had liver transplantation from hbsag positive donor ⑫ recipients or donors are hiv, hcv positive ⑬ patients who need to systemc chemotherapy or immunosuppressive therapy prior to transplantation or took immunosuppressants within 30 days prior to liver transplantation(except, investigational products per protocol and corticosteroid) ⑭ patients who have hypersensitivity to mycophenolate, mycophenolate acid, ingredient of investigational products, tacrolimus , macrolide antibiotic and steroids ⑮ patients who had been received or have been received other investigational products within 28 days prior to screening 16 pregnant women and lactating women 17 substance abuse patient, mentally defective person or patients who is not possible to participate in clinical trial by law 18 investigator judge that a patient have communication disorder 19 patients are not capable of visiting accor.ding to study visit schedule 20 investigator judge that a patient is not proper to enroll this study, et cetera

Keywords: hbv
walking program in fatty liver children with phenylketonuria

Conditions: Phenylketonurias; Non Alcoholic Fatty Liver

Summary: phenylketonuria (commonly known as pku) is an inherited disorder that increases the levels of a substance called phenylalanine in the blood. pku is usually associated with many metabolic complication including non-alcoholic fatty liver

this study will include pku children sufferers 9n=40) with non-alcoholic fatty liver to be randomly assigned to group i (n=20) that will perform walking program (online supervised free walking that will be applied daily for eight weeks) or group ii (n=20) that will act as waitlisted children

Eligibility criteria:
inclusion criteria: * pku children * obese children * fatty liver children (non-alcoholic fatty liver) exclusion criteria: * cardiac children * diabetic children * neurogenic disorders * respiratory and renal problems
relationship between neutrophil function and sepsis in adults and children with severe thermal injuries

Conditions: Burns

Summary: the study aims to validate neutrophil function, immature granulocyte and plasma free dna levels as predictive diagnostic biomarkers of sepsis in burn patients. inclusion criteria includes healthy volunteers, patients aged 5-15 years old with burns affecting 20% or less total body surface area (tbsa) and patients aged 16 or above with burns affecting \>15% tbsa. the study involves taking blood, tissue and urine samples.

the initial cohort for sifti-2 will be generated from patients attending the birmingham burns centre at queen elizabeth hospital birmingham (qehb) and birmingham children's hospital (bch). the cohort will be comprised of patients with moderate and severe burns (injury to more than 15% of the body surface area \[tbsa\] in adults and 20% tbsa in children). the investigators currently treat between 30-40 patients in this category each year. in order to thoroughly characterise the longitudinal neutrophil response to burn injury and to investigate its potential relationship with outcome post-burn, the ivestigators will measure the genomic, phenotypic and functional response of peripheral blood neutrophils across time in burn-injured patients.

Eligibility criteria:
inclusion criteria: * patients aged 1-15 years admitted with a ≥20%tbsa * patients aged 16 and over admitted with a ≥15% tbsa * patients presented within 24 hours of thermal injury exclusion criteria: * associated multiple injuries with injury severity score \> 25 * decision not to treat made on admission due to the severity of the injury * patients with chemical and deep electrical burns * premorbid conditions * active malignancy * patients receiving glucocorticoid treatment * multiple limb amputations * patients with known long term infections (i.e., hepatitis b \& c, human immune deficiency \[hiv\])
a study of the effects of intake of two cod residual meals on glucose regulation in overweight and obese adults

Conditions: Overweight; Obesity

Summary: the investigators have previously shown the intact protein from cod filet improves glucose regulation and serum lipid profile in overweight adults. a large amount of trimmings from various fish species such as cod is thrown away or sold at very low prices for animal feed, and analyses of the amino acid composition reveals that this can be a good protein source for humans. two fractions are normally isolated from intact fish meal, i.e. water soluble and non-water soluble proteins. in the present study the investigators will compare these fractions, by studying their effects on glucose regulation in overweight/obese adults.

participants receive 6g per day of water soluble on non-water soluble cod protein as tablets for 8 weeks.

Eligibility criteria:
inclusion criteria: * bmi\>28 * healthy * fasting blood glucose \<7.0 mmol/l * stable body weight with less than 5 kg fluctuation during the last 4 months exclusion criteria: * known disease or metabolic disturbances related to overweight or obesity * use of prescription medications that affect blood glucose, blood lipids or inflammatory status * allergies towards fish or seafood * undertaking a weight loss diet * tobacco use exceeding \>15 cigarettes/day * pregnancy or breastfeeding * high seafood consumption * use of dietary supplements including cod liver oil or other marine fatty acids * allergies towards fish, milk, egg