Kornimate/medical-research-clean huggingface dataset:
combining wearable robotic orthosis with visual and haptic feedback to enhance the recovery of upper extremity motor function and adl in persons with acute sci

Conditions: SCI - Spinal Cord Injury

Summary: this randomized clinical trial (rct) is evaluating the usefulness of combining myomo robotic orthosis with visual and haptic feedback in ameliorating wrist/hand/ue movement capability, and increasing adl and quality of life in people with acute sci.


Eligibility criteria:
inclusion criteria: * be between the ages of 18-80 * be able to activate the muscles of my upper arm and forearm with enough strength as determined by the therapist. * be diagnosed with a spinal cord injury (isci (asia impairment scale (ais) c and d) and be less than 3 months post initial injury at the start of the study * be medically stable * be able to follow study directions and communicate in english as determined by the study staff * continue to take all prescribed medication (example: baclofen: oral or via pump) without any major dosing changes * be able to tolerate functional tasks for 60min with intermittent rests without excessive fatigue * have full passive range of motion at my elbow, as determined by study staff exclusion criteria: * be younger than 18 years old or older than 80 * have excessive pain in my arm or hand that would limit my participation in rehabilitation * have excessive spasticity in my elbow or wrist joints as determined by study staff * be participating in any experimental rehabilitation or drug studies * have a history of neurologic disorder other than spinal cord injury * have other conditions that would prevent safe and/or effective participation using the study device. examples of these conditions include: severe sensory deficits, skin conditions, joint contractures, etc. * have difficulty following multiple step directions * have severe psychiatric problems or difficulty thinking clearly that would prevent me from participating in this study * have skin issues that would prevent wearing the myo-pro device * have had history of recurrent epilepsy, seizure or convulsion * have a past or current history of treated ringing in the ears known as tinnitus or severe hearing problems. * be taking any drugs that would increase my risk of having a seizure while undergoing brain stimulation. study staff and physician will review my medications to see if i am taking any of these drugs. if i am taking one of these drugs, i will not be enrolled in this study. * because of potential risk to the fetus, women of child-bearing potential will be required to have a pregnancy test before they can enroll in this study. if i am female, and have a positive pregnancy test, i will not be enrolled.
effect of kt taping on waist-to-hip ratio, abdominal strength and body image concerns in postpartum females.

Conditions: Postpartum Disorder

Summary: this study is aimed at determining the effect of kinesio taping on waist to hip ratio, abdominal muscle strength and body image concerns in postpartum females.

post caesarian section there is abdominal weakness and an increase in fat ratio. there is a significant decrease in strength of abdominal muscles and an increase in fat ratio after the c section. common increase in abdominal circumference in postpartum females and its long term outcomes like women health orders change in body shape and dissatisfaction is arising very commonly in society. body image concern inventory scale is used to assess dysmorphic concern of body. this study will work on the effects of kinesiotaping which will be easily applicable and increase muscle activation along with abdominal exercises to regain lost muscle strength and tightening of loose skin. this tapping technique has a therapeutic effect on muscles and easily available in the rehabilitation department. nowadays it is becoming very common, easily available, and regarded by physiotherapists as a method to support, rehabilitate and stimulate some physiological processes. this study aims at determining rehabilitative treatment to reduce waist circumference in post partum females.

Eligibility criteria:
inclusion criteria: * prima parous females, eight weeks post-partum. * females with both vaginal delivery and c section. exclusion criteria: * females who received previous abdominal or spinal surgeries. * females having infection in sutures. * females having abdominal hernia, skin sensitivity * females having moderate to severe diastasis recti (ird more than 3 finger width). * neurological impairment affecting muscle performance.

Keywords: waist circumference waist to hip ratio body image post partum exercise
the clinic study to prevent pulmonary embolism in patients with general anesthesia operation in perioperative period

Conditions: Pulmonary Embolism

Summary: the purpose of this study is to investigate the prevention of pulmonary embolism in patients who with general anesthesia operation in perioperative period.

patients who received general anesthesia operation in beijing chaoyang hospital affiliated to capital medical university were collected. the incidence of pulmonary embolism in perioperative period and age, gender,the surgery , clinical stage, clinical efficacy assessment will be further analyzed.

Eligibility criteria:
inclusion criteria: * the first time to accept the general anesthesia operation exclusion criteria: * pregnancy. * the function of liver and kidney disorder or serious abnormal electrolyte. * the abnormal coagulation dysfunction and blood volume.

Keywords: pulmonary embolism; perioperative period; general anesthesia
the application of the pdca management model in improving the diagnostic accuracy of aig

Conditions: Autoimmune Gastritis

Summary: autoimmune gastritis is currently relatively rare in china due to its insidious onset, diverse clinical manifestations involving multiple systems such as digestive, hematological, and nervous systems, and its association with other autoimmune diseases. it can also be complicated by hyperplastic gastric polyps, gastric neuroendocrine tumors, gastric adenocarcinoma, and other diseases, making it prone to clinical misdiagnosis. as a form of gastritis in the post-helicobacter pylori era, its detection rate has been gradually increasing with the continuous improvement of endoscopic technology in china. applying the pdca cycle management in disease diagnosis can significantly improve the detection rate of the disease, benefiting patients. through the pdca management model, this study further enhanced gastroenterologists' understanding of this disease from various aspects, aiming to improve the clinical diagnosis of autoimmune gastritis.


Eligibility criteria:
inclusion criteria: endoscopy center gastroenterologists in our hospital in 2024 exclusion criteria: doctors who withdrew from the pdca management midway and stopped undergoing gastroscopy.
biatrial contractility recovery after maze

Conditions: Atrial Fibrillation

Summary: this study aimed at evaluating multiple aspects of biatrial contractility recovery after modified maze procedure during mitral valve surgery.

atrial fibrillation (af) is a frequent complication in patients affected by mitral valve disease, causing systemic embolism, cardiac chamber dilation and decreased cardiac output. cox et al. have designed the maze procedure as a surgical treatment for patients with af in whom conventional therapy has failed and their lesion set is nowadays currently performed with different energy sources in order to surgically treat such supraventricular arrhythmia. in particular, the original maze was designed with three specific goals in mind: 1) the permanent af ablation 2) the restoration of atrioventricular synchrony and 3) the preservation of atrial transport function (1). if , by one side, the efficacy of the procedure in reaching the first two goals are widely known, the restoration of the sinus rhythm does not always accompany the corresponding recovery of atrial mechanical "kick". if the atrial transport function fails to recover, benefits deriving from arrhythmia abolition might only be marginal, since, by one side, blood stasis in the atria persist, thus maintaining unchanged thromboembolic risk and, by the other side, heart hemodynamic performance is still impaired resulting from the loss of atrial contribution to cardiac output. despite its relevant role for judging maze comprehensive success, atrial contractility outcome and clinical importance have not been deeply investigated. the purposes of this study were to evaluate by serial transthoracic echocardiography temporal modality of biatrial contractility restoration, predictive factors of atrial transport recovery and its possible relationship with cardiac chambers dimensions and function evolution after radiofrequency (rf) maze during mitral surgery.

Eligibility criteria:
inclusion criteria: * patients affected by atrial fibrillation undergoing mitral valve surgery exclusion criteria: * other cardiac procedures in addition to mitral valve surgery
feasibility of vaginal progesterone to reduce hiv-associated preterm birth

Conditions: PreTerm Birth

Summary: more than 1.5 million hiv-infected women become pregnant each year. approximately half have access to antiretroviral therapy (art), but all are at increased risk of preterm birth (ptb). vaginal progesterone (vp) is a promising and cost-effective intervention to prevent ptb that should be studied in this high-risk population. this pilot study will provide critical insight into the feasibility of a phase iii trial by determining whether women are willing to participate, to adhere to study drug, and to complete follow-up.

this will be a mixed method study to evaluate the feasibility and acceptability of a trial of vp to prevent ptb among hiv-infected zambian women. to assess the feasibility of a full-scale clinical trial, the investigators will implement a pilot two-arm, double-masked, placebo-controlled trial of vp among hiv-infected women in antenatal care in lusaka, zambia. participants will be randomly assigned to either daily self-administered vp or indistinguishable placebo prior to 24 weeks gestational age. in this pilot study, the investigators will be able to estimate study uptake, adherence to study product and protocol, and study retention. to assess the acceptability of a trial to test vp among hiv-infected women in zambia, the investigators will employ a qualitative approach of longitudinal semi-structured interviews among women agreeing to trial participation and one-time semi-structured interviews (ssis) among those who decline to participate.

Eligibility criteria:
inclusion criteria: 1. 18 years of age or older 2. viable intrauterine pregnancy confirmed by ultrasound 3. presentation to antenatal care prior to 24 weeks gestation 4. antibody-confirmed hiv-1 infection 5. initiating or continuing art treatment in pregnancy 6. ability and willingness to provide written informed consent 7. willing to adhere to study visit schedule exclusion criteria: 1. multiple gestation 2. non-research indication for antenatal progesterone (i.e. prior spontaneous ptb and/or cervical length \<20mm on screening ultrasound) 3. planned or in situ cervical cerclage 4. evidence of threatened abortion, preterm labor, or ruptured membranes 5. major fetal anomaly detected on screening ultrasound 6. known uterine anomaly 7. known or suspected allergy or contraindication to vp or placebo components

Keywords: preterm birth hiv vaginal progesterone art adherence feasibility
effect of an internet-based at-home physical training protocol on quality of life, fatigue, functional performance, aerobic capacity and muscle strength in multiple sclerosis patients

Conditions: Multiple Sclerosis

Summary: in this randomised controlled trial, the feasibility and effectiveness of an internet-based exercise intervention including progressive strength and endurance training (e-training) for pwms was investigated. primary outcome was health-related quality of life, secondary outcomes were muscle strength, aerobic capacity and lung function, physical activity and fatigue.


Eligibility criteria:
inclusion criteria: * diagnosed multiple sclerosis (mcdonald criteria), * an edss score of less than or equal to 4.0, * not less than 4 weeks of clinical stability prior to inclusion in the study, * access to the internet. * the taking of immunotherapeutic agents was not relevant and not monitored exclusion criteria: * primary progressive multiple sclerosis * clinically relevant internal disease, especially cardiovascular or pulmonary disease, metabolic and orthopedic diseases

Keywords: multiple sclerosis quality of life exercise internet
glycosaminoglycan scores as monitoring biomarkers in confined renal cell carcinoma

Conditions: Carcinoma, Renal Cell

Summary: in this study, a score based on glycosaminoglycan (gag) profiling in subjects with suspicion of renal cell carcinoma (rcc) is hypothesized to distinguish malignant masses when early actionable clinical decisions are desirable. for example to diagnose early recurrence after surgical treatment; to screen population at risk of rcc; or to distinguish benign masses from rcc before surgical treatment. to this end, plasma and urine gags will be measured in a prospective cohort of patients referred to surgical treatment for rcc. the resulting gag scores are then correlated to post-surgical recurrence, to post-surgical definitive diagnosis and and to tumor size if rcc. in a subset cohort of patients at high risk of rcc recurrence, plasma and urine gags will be monitored to observe its correlation with disease recurrence.


Eligibility criteria:
inclusion criteria: * patients referred for partial or radical nephrectomy for suspicion of renal cell carcinoma * predicted life expectancy over 2 months * standard imaging evaluation 12 weeks prior to inclusion * planned for standard imaging within 16 weeks after start of therapy exclusion criteria: * lack of proper compliance to accept continuous samplings.
a prospective study on the incidence and related risk factors of infantile hemangioma in china

Conditions: Infantile Hemangioma; Capillary Hemangioma; Capillary Hemangiomas; Hemangioma, Capillary Infantile; Strawberry Hemangioma

Summary: infant hemangioma(ih) is the most common benign vascular tumor of infancy with the estimated incidence varies 1% to 12%.however, in china, the incidence of infant hemangioma and related epidemiological data remains unclear. so, the investigators designed the study for the following purposes: 1, to aware the incidence of infantile hemangioma and understand the related risk factorsin china; 2, to understand the clinical characteristics of infantile hemangioma and the risk factors for complications; 3, to investigate the level of knowledge, treatment options in infant hemangioma in chinese doctors; 3, to improve the awareness of infantile hemangioma in parents and provide more advice for pregnancy counseling and eugenics.


Eligibility criteria:
inclusion criteria: * chinese * the infants within 12 months of age exclusion criteria: * those whoes guardian does not want his data to be collected in this study

Keywords: hemangioma
upper airway stability during wakefulness and sleep

Conditions: Sleep Apnea Syndromes; Snoring

Summary: negative expiratory pressure is a technique that has been the focus of many studies in the last few years. airway response to the application of a negative expiratory pressure (nep) can be used to detect the presence of upper airway collapsibility. in normal subjects, an increase in expiratory flow is observed while in patients with collapsible upper airway, the flow will show a transient decrease due to airway collapse. the objectives of this study will be initially to investigate the diagnostic utility of this technique as a noninvasive measurement of the stability of the upper airway in sleep-related breathing disorders. secondly, we aim to see the sites of airway obstructions, discovered by nep, through nasal endoscopy. finally, we aim at testing the utility of nep technique in the evaluation of therapeutic response. for this purpose, we will apply it in patients before and after airway stabilization interventions like ent surgery, oropharyngeal exercises, orthodontic mandibular advancement electrical stimulation of the hypoglossal nerve.


Eligibility criteria:
inclusion criteria: - exclusion criteria: * patients with copd

Keywords: negative expiratory pressure, sleep apnea, snoring, sleep-disordered breathing
adding an insulin-sensitizing medication to depression treatment for people who are depressed and overweight

Conditions: Depression

Summary: this study will determine whether the drug metformin improves the effects of traditional antidepressant medications in people who are overweight.

current depression treatments are not effective for approximately one-half of overweight people, and depression eventually returns in approximately one-third of those overweight people whose initial treatment is effective. one possible reason for these treatment failures is that overweight people often experience a condition called insulin resistance (ir), which can lead to type 2 diabetes, an associated disease that might also affect depression treatment. ir results in elevated blood sugar levels that may interfere with medications used to treat depression. metformin, a medication commonly used to treat diabetes, reduces blood sugar levels. this study will examine whether taking metformin with the antidepressant medication sertraline will enhance the effectiveness of sertraline in people who are overweight and depressed. participation in this study will last a total of 16 weeks and will include baseline testing and ten scheduled study visits. participants will be randomly assigned to receive either sertraline and metformin or sertraline and placebo on a daily basis. the baseline visit will include the following tests and measures: an electrocardiogram (ekg), which will measure the electrical activity in the heart; an oral glucose tolerance test (ogtt), which will measure how a person's body breaks down glucose; a blood test, which will measure lipids, glycosylated hemoglobin (a1c), and other cardiometabolic risk factors; a dual energy x-ray absorptimetry (dexa) scan, which will measure body fat; a pregnancy test for women; measurements of vital signs, height, weight, waist-to-hip ratio, and waist circumference; and questionnaires concerning health, medication use, physical activity, diet, and mood. some of the questionnaires will be administered through interviews with a researcher. during the study visits, which will occur every 2 weeks, participants will complete questionnaires, unused medication will be collected, and new medication will be handed out. at week 8, participants will provide an additional blood sample by finger stick.

Eligibility criteria:
inclusion criteria: * body mass index (bmi) greater than 28.7 * positive screening for depression * must live within 100 miles of the st. louis metropolitan area exclusion criteria: * pregnant or breastfeeding * known hypersensitivity to sertraline or metformin * recent history of heart attack or unstable heart disease * severe liver disease or kidney impairment, defined by a serum creatine level above 3 mg/dl * psychiatric disorder thought to affect management, such as schizophrenia, or alcohol or drug dependence

Keywords: metabolic diseases depressive disorder, major depressive disorder glucose metabolism disorders depression recurrence
home treatment of acute pancreatitis

Conditions: Acute Pancreatitis

Summary: acute pancreatitis (ap) is considered a disease requiring in-hospital treatment. we studied the feasibility of home management in ap.the aim of study was to compare 30 day readmission rates in patients with mild non-alcoholic acute pancreatitis (naap) randomized to home monitoring versus hospitalization.

between 11/11-5/12, 84 patients with mild naap were randomized to home or hospital groups after a short (≤24 hours) hospital stay. ap was defined as ≥2 or more of the following: characteristic abdominal pain, amylase and/or lipase ≥3x the upper limit of normal, and/or imaging findings. patients with an imrie's score ≤5 and a harmless acute pancreatitis score (haps) ≤2 were included. patients in both groups received intravenous lactated ringer for 3 days and pain was treated with intramuscular diclofenac. a nurse visited all patients in the home group on the 2nd, 3rd and 5th day. all patients recalled for follow-up on the 7th, 14th, and 30th days.

Eligibility criteria:
inclusion criteria: * diagnosis of ap based on 2 out of 3 findings: characteristic abdominal pain, amylase and/or lipase levels ≥3 times the upper limit of normal, and/or abdominal imaging demonstrating changes of acute pancreatitis * presentation within 48 hours of symptom onset * imrie's scores of ≤5 and hap score ≤2 within 24 hours of presentation to the hospital * lack of hemoconcentration (hematocrit ≥44%) on presentation since hemoconcentration has been shown to be a risk factor for pancreatic necrosis. exclusion criteria: * the presence of organ failure by the atlanta criteria on the first day of presentation * the presence of clinical signs and/or symptoms of sepsis * alcoholic acute pancreatitis * a history of abdominal imaging demonstrating a dilated pancreatic duct and/or pancreatic calcifications * coagulopathy (international normalized ratio \>1, and/or platelet count \<50,000/mm3 * comorbidities requiring hospitalization regardless of the presence of ap e.g. acute myocardial infarction, malignancy, cirrhosis, chronic kidney disease, and chronic pulmonary disease)

Keywords: acute interstitial pancreatitis home therapy
microwave coagulation using croma electrosurgical system

Conditions: Polyp of Large Intestine

Summary: this is a single centre, prospective, non-randomised pivotal clinical investigation to be undertaken at st mark's hospital, harrow, uk.

the study will recruit 30 patients undergoing endoscopic resection of complex colorectal polyps and be used to demonstrate safety and performance of the croma electrosurgical system microwave coagulation modality. study data will complement existing data to support a ce marking application for the croma electrosurgical system (combined rf and microwave modalities).

Eligibility criteria:
inclusion criteria: * male or female, at least 18 years of age; * after standard clinical work-up a benign appearing lower bowel lesion \>2cm in diameter; * patient or authorised representative able to comprehend and sign the informed consent prior to enrolment in the study. exclusion criteria: * aged \<18 years of age; * pregnant or lactating females; * lower bowel lesions \<2cm in diameter; * patients receiving regular systemic steroids; * patients who are immuno-compromised (either acquired or congenital); * patients with a known coagulopathy (either acquired or congenital); * patients on anti-platelet therapy at the time of the procedure, apart from low dose (75mg) aspirin alone; * concurrent participation in another experimental intervention or drug study; * unwilling or unable to provide informed consent.