Kornimate/medical-research-clean huggingface dataset:
stereotactic radioablation by multimodal imaging for vt (stra-mi-vt)

Conditions: Refractory Ventricular Tachycardia

Summary: study of multimodal-imaging guided stereotactic body radiotherapy (sbrt) for ventricular tachycardia (vt) ablation.

stra-mi-vt study is a spontaneous, open-label, not randomized, prospective clinical trial. the objective of the study is to evaluate the safety and efficacy of sbrt in strictly selected patients with refractory vt. multimodal cardiac imaging combined with electroanatomic mapping to provide a specific patient's tailored sbrt treatment plan choosing amang different linear accelerators.

Eligibility criteria:
inclusion criteria: * icd/s-icd recipients with refractory vt * not eligible for conventional catheter ablation or -in alternative- that have undergone failing conventional catheter ablation attempts, refusing surgery for the treatment of the arrhythmia. * lvef ≥ 20%. * age ≥ 50 years. * signed an irb approved written informed consent document. exclusion criteria: * previous radiotherapy with cardiac involvement. * pregnancy or breastfeeding. * active myocardial ischemia. * acute revascularation in the past 120 days. * acute hemodynamic instability (cardiogenic shock/nyha iv). * serious disease with presumed life expectancy less than 12 months. * any condition that is deemed a contraindication in the judgment of the investigators.
somatropin (norditropin) in insulin-like growth factor (igf) deficient children

Conditions: Growth Hormone Disorder; Pituitary Dwarfism

Summary: this trial is conducted in the united states of america (usa). this is a 12 month study to determine if norditropin is safe and effective in children with igf deficiency.


Eligibility criteria:
inclusion criteria: * ages 3-15 * presence of growth failure indicated by height standard deviation score less than equal to -2 * body mass index greater than or equal to 25th percentile for height age * igf concentration less than or equal to 33rd percentile

Keywords: growth hormone disorder
mindful yoga for postpartum depression

Conditions: Mood Disorders

Summary: this is a parallel-group randomized controlled trial. a total of 198 postpartum women with depressive symptoms (epds scores≥8 at baseline) will be recruited and randomized into two groups: 10-week mindful yoga intervention and 10-week psychoeducation program. clinical assessment of depression, self-report questionnaires and salivary cortisol tests will be performed at baseline, after 10-week intervention, and at 6-month and 12-month follow-ups. the investigators expected that the mindful yoga intervention will reduce depression after 10 weeks compared to psychoeducation. the mindful yoga intervention will further reduce anxiety, stress, improve quality of life and sleep, and steepen diurnal cortisol slopes. these effects will be maintained for at least six months.


Eligibility criteria:
inclusion criteria: * postpartum women aged 18-60 years old. * the scores of epds ≥ 10. * at least 6 week and up to 1 year after childbirth. * giving birth to a single full-term healthy baby (gestation between 37-41 weeks, body weight \> 2.5kg, apgar score at 5 minutes \> 7). * fewer than 10 hours of yoga/qi gong/tai chi or mindfulness/meditation practice in the previous 3 months. exclusion criteria: * severe complications after delivery, or their infants are admitted to nicu. * regular psychiatric follow-up. * currently taking antipsychotic drugs. * known pragnancy, or other contraindications to physical exercise (e.g., wound healing situation) according to the body examination by o\&g clinicians at 6 weeks after delivery.

Keywords: yoga mindfulness-based postpartum depression mood symptoms
tau pet in imaging and cognition: healthy adults from 55-90

Conditions: Mild Cognitive Impairment; Aging

Summary: the investigators aim to use the new pet radioligand, 18f-mk-6240, to detect tau pathology in cognitive healthy and mild cognitive impairment (mci) elders. the investigators will then examine the interactions between differential tau burden and performance on cognitive tasks, functional magnetic resonance imaging (fmri) neural activation patterns, and other cognitive and behavioral measures. by investigating these relationships, the investigators hope to understand the cognitive and behavioral outcomes of tau deposition found in specific brain regions in cognitively normal/mildly cognitively impaired adults. furthermore, the study aims to examine how the presence of tau may contribute to the risk of subsequent cognitive decline, neurodegeneration, and dementia.

many cognitively healthy older adults have, upon post mortem evaluations, been found to have varying amounts of neurofibrillary tangles (tau) and beta-amyloid plaque deposits, which are the hallmark brain pathologies known to be associated with alzheimer's disease and various other dementias. while some with these pathologies may not clinically express cognitive decline or dementia in their lifetime, human post-mortem studies suggest that increasing neurofibrillary tangle density correlates with neurodegeneration and cognitive impairment. imaging tauopathy in-vivo provides an opportunity to examine neurocognitive correlates of differential levels of tauopathy in the brain, allowing to further qualify pre-clinical states of cognitive impairment. the investigators aim to investigate possible protective mechanisms, such as cognitive reserve, that may modulate the relationship between tauopathy and cognitive decline.

Eligibility criteria:
inclusion criteria: * aged 55-90 * previously received an amyloid pet scan * residing near columbia university medical center * must be willing and able to participate exclusion criteria: * have a contraindication to pet (e.g, metallic implants, pacemaker, claustrophobia, or cannot lie flat for one hour) * pregnancy * lactating women * current, past, or anticipated exposure to radiation * significant active physical illness

Keywords: tau mk-6240 cognition
laparoscopic approach for emergency colon resection

Conditions: Laparoscopic Surgery; Colorectal Cancer; Colorectal Disorders; Emergencies; Complication of Surgical Procedure; Long-term Effects of Cancer Treatment

Summary: this is a randomized, controlled, parallel, multicenter trial to compare post-operative complications and long-term results between open and laparoscopic technique in emergency colorectal surgery.

laparoscopic technique in elective colorectal surgery has been shown to be advantageous for patients compared to open technique. however, the feasibility and potential benefits of laparoscopic colorectal surgery in emergency setting has not been evaluated sufficiently. the aim of this study is to compare laparoscopic and open technique in emergency colon resections. primary outcome is the immediate recovery after operation and secondary outcome is long-term overall and cancer-specific survival.

Eligibility criteria:
inclusion criteria: * all patients in need of emergency colon resection exclusion criteria: * age \< 18 year * trauma patients * reoperations * acute pancreatitis

Keywords: laparoscopic surgery emergency surgery colorectal
comparing site-selection strategies

Conditions: Deafness

Summary: several studies in the past have tried to deactivate electrodes that are less optimal to improve speech recognition outcomes. the study aims to compare the measures based on which the deactivation was performed. the investigators aim to first examine if the measures are strongly correlated each other, and then compare the deactivation effects across measures. these measures are mainly behavioral including electrode discrimination, amplitude modulation detection thresholds, low-rate and focused detection thresholds and electrode-modiolus distance. the endpoint of the study is speech recognition performance post deactivation.


Eligibility criteria:
inclusion criteria: * native speakers of english * cochlear nucleus cochlear implant users or advanced bionics users * postlingually deafened * has had device experience for at least one year * can be child or adult at the time of enrollment exclusion criteria: * none
bridging community gaps photovoice

Conditions: Mental Illness; Social Isolation

Summary: the purpose of this study is to test a peer-led intervention intended to promote the community living and participation of individuals with psychiatric disabilities entitled "bridging community gaps photovoice" (bcgp). the intervention targets increasing community involvement of individuals with psychiatric disabilities through reduction in self-stigma and perceived stigma, enhancing opportunities for community participation, and support to achieve community participation goals.

the bcgp intervention is 6 months long and the investigators expect that participants will experience lower self and perceived stigma, increased community participation and sense of belonging, and improved psychosocial functioning and personal growth after the intervention. the intervention is comprised of a 12-week class that meets once a week for two hours, followed by three booster sessions - one per month in the three months following the class, and up to 24 sessions of individual support as needed throughout the 6 months provided on a weekly basis either in person or by phone. the purpose of the individual support is to reinforce the class activities and to ensure the participants meets their community participation goal. the proposed study is a randomized trial which will be conducted at boston university center for psychiatric rehabilitation (bucpr) in massachusetts, the mental health center of denver (mhcd) in colorado, and the greater bridgeport mental health center (gbmhc) in connecticut.

Eligibility criteria:
inclusion criteria: 1. are 18 or older. 2. are recipients of services at research sites due to having a dsm-v diagnosis of mental illness, including dual diagnosis (dual diagnosis refers to co-occurring mental illness and alcohol/ substance use disorder). 3. are interested in enhancing their community participation. 4. are not currently receiving individual peer support services. 5. are able to read and write in english. exclusion criteria: 1)inability to give full and knowing consent.

Keywords: mental illness community participation stigma photovoice
unreamed intramedullary tibial nailing in treatment of open iiia diaphyseal tibial fractures in adults

Conditions: Tibia Fracture

Summary: to study the incidence of non union of unreamed intramedullary nailing in type iiia open diaphyseal fractures of the tibia as a primary outcome and the incidence of complications and clinical and functional outcome as a secondary outcome .

tibia is one of the most common bones to sustain open injury because of its superficial nature.concerns over the high rates of malunion, nonunion, and deep infection have resulted in the development of aggressive treatment protocols including emergent wound exploration, thorough irrigation and debridement, bony stabilization, judicious antibiotic therapy, repeated wound debridements, and early soft-tissue coverage. however, there is still controversy regarding the optimal method of skeletal stabilization. high rates of pin tract infections, poor patient compliance, and malunion rates of 20% and greater have limited the use of external fixators as a definitive form of fixation.despite initial encouraging results, plate fixation of open tibial fractures has been associated with implant failures, nonunions, and deep infection rates as high as 35%.6as a result, locked intramedullary nailing has become the standard treatment for open tibia fractures enabling axial alignment, early weight bearing, and immediate knee and ankle motion. despite this, the complications including a high incidence of local bony necrosis and sepsis that occur following reamed intramedullary nails have led some to discourage the use of this method of skeletal stabilization in open tibia fractures.intramedullary tibial nail insertion without reaming has the advantage of minimal endosteal blood supply disruption and thus supposed to have increased union rate and reduction of infection rate . sanders et al 11 reported on the treatment of 64 patients with open tibial shaft fractures using unreamed interlocked intramedullary nails. all but 1 of the fractures healed with excellent alignment and an overall chronic infection rate of 4%.other studies reported similar results .12 type and timing of fixation were important determinants of infection , with people who received intramedullary nailing within 24 h having the lowest risk of infection .utn significantly reduced the incidence rates of superficial infection and malunion compared with ef, suggesting that it is likely a safe and effective alternative to ef for treating open tibial fractures. however patients' postoperative weight bearing should be controlled to avoid hardware failure. here,our purpose is to investigate the outcome of unreamed intramedullary nail in open diaphyseal fractures of the tibia in our setup .

Eligibility criteria:
inclusion criteria: 1. open grade iiia diaphyseal tibial fractures . 2. skeletaly mature patients . exclusion criteria: 1. late presentation and open infected fractures . 2. associated intraarticular fractures of proximal /distal tibia.
the effects of preoperative aspirin on graft patency and cardiac events in off-pump coronary artery bypass

Conditions: Coronary Artery Disease; Off-pump Coronary Artery Bypass; Aspirin

Summary: antiplatelet therapy is critical in the management of coronary artery disease.for patients undergoing off-pump coronary artery bypass graft,controversy remains regarding the safety of preoperative antiplatelet therapy.and there is little study about the effect of continuing aspirin until the surgery day on graft patency.so we would like to perform this study to evaluate the effects of preoperative aspirin on graft patency and cardiac events in off-pump coronary bypass.


Eligibility criteria:
inclusion criteria: * patients undergoing elective, off-pump coronary artery bypass with at least two grafts * patient able to give informed consent exclusion criteria: * on-pump cabg * combined with the valve surgery * preoperative use of clopidogrel and warfarin * allergy to aspirin * history of severe liver disease * history of bleeding diathesis,significant gi bleed * patient has known renal failure or contraindication for cardiac ct angio * redo cabg

Keywords: coronary artery disease off-pump coronary artery bypass aspirin
behavioral markers of pre-operative anxiety

Conditions: Preoperative Anxiety

Summary: the purpose of this study is to identify the characteristics of patients' behavioural patterns related to declared anxiety levels in a day-care surgical unit using ethological analysis of video-recordings of the pre-operative interview with the nurse.

guidelines in anaesthesia recommend systematic preoperative anxiety management to prevent negative perioperative impact, including impaired memory of important instructions and high incidence of post-operative acute and chronic pain. self-administered questionnaires linked to scales to assess anxiety in the preoperative setting are usual practice. yet, they are time consuming and rely on patient willingness to comply with instructions, which is not always reliable. the effects of acute anxiety on behaviour are poorly explored in the preoperative context. quantifying and characterizing behavioural patterns in anxious patients using an applied ethological approach may provide useful information for reliable, accurate and objective assessment before surgery.

Eligibility criteria:
inclusion criteria: * adult patients scheduled for elective ambulatory surgery exclusion criteria: * communication difficulties

Keywords: preoperative anxiety ethology behavioural markers objective detection
subthreshold micropulse laser treatment of acute central serous chorioretinopathy

Conditions: Acute Central Serous Retinopathy With Subretinal Fluid

Summary: to evaluate the efficacy and safety of 532 nm green subthreshold micropulse laser (gsml) as a treatment for acute central serous chorioretinopathy (cscr).

this prospective study included 42 eyes of 42 patients with acute cscr treated with iridex™ iq 532 nm gsml. the study was conducted at minia university hospital and genaidy ophthalmology center, minia, egypt between october 2019 and may 2022. all patients were subjected to a complete ophthalmological examination, fluorescein angiography (fa) and optical coherence tomography (oct) at baseline and each follow-up visit 1, 3 and 18 months after laser treatment

Eligibility criteria:
inclusion criteria: * acute cscr exclusion criteria: * chronic cscr previously treated case of acute cscr
correlation between respiratory variability of r-r intervals and systolic pressure variability

Conditions: Heart Rate Determination

Summary: this prospective study is designed to assess and quantify the correlation between respiratory changes in r-r interval and the respiratory changed in invasive systolic blood pressure in ventilated patients during changes in posture and peak end expiratory pressure (peep) and following a fluid bolus


Eligibility criteria:
inclusion criteria: * age 18-80 * scheduled for surgery under general anesthesia requiring invasive blood pressure monitoring exclusion criteria: * heart rate other than sinus * cardiac pacemaker status * transplanted heart
chronic obstructive pulmonary disease in combination with atherosclerosis (clinical and biochemical study)

Conditions: Chronic Obstructive Pulmonary Disease; Peripheral Artery Disease

Summary: one-centered, open, non-randomized, controlled clinical trial will focus on a comprehensive study of the clinical, functional and molecular biochemical characteristics of the natural course of copd in combination with peripheral atherosclerosis

risk factors, chronic respiratory symptoms and respiratory function in the natural history of copd will be monitored. in a group of patients with a comorbid course of copd and atherosclerosis, systemic inflammation and its molecular mechanisms will be investigated. also in this group, the role of non-coding mirnas will be analyzed. the study also includes an analysis of the clinical and biochemical copd phenotype with systemic inflammation and comorbidity.

Eligibility criteria:
inclusion criteria: 1. a significant diagnosis of copd, confirmed by spirometry criteria, typical clinical presentation. 2. a significant diagnosis of peripheral atherosclerosis 3. the high level of adherence to treatment 4. signed informed agreement exclusion criteria: 1. the presence of other chronic respiratory diseases in the patient, including bronchial asthma 2. known oncological diseases of any localization 3. hiv infection and other immunodeficiency conditions 4. inability to understand and comply with the requirements of the research protocol.

Keywords: copd peripheral atherosclerosis comorbidity
photodynamic in periodontal treatment

Conditions: Periodontal Diseases; Periodontal Pocket

Summary: dental biofilm is a primary etiological factor for periodontal diseases.(1) the bacterial biofilm would induce recruitment of leucocytes, neutrophils, and t lymphocytes and the secretion of antibodies, lipopolysaccharides, and chemical inflammatory mediators such as cytokines and chemokines.(2) thus, periodontal diseases can cause tissue destruction and results in deterioration of clinical parameters measures such as periodontal pockets depth, clinical attachment loss, bleeding on probing, bone destruction, and resulting ultimately in tooth loss.(3)

mechanical scaling and polishing are the conventional methods in treating periodontal diseases; however, due to difficulties in access to the irregular and furcation areas, it is impossible to be used as a sole means for calculus and bacterial deposit removal.(4) for this reason, adjunctive aids like systemic and local antibiotics are necessary to be administrated however, they have many adverse effects.(5) another adjunctive aid like antibacterial photodynamic therapy (apdt), has been introduced to periodontology to achieve bacterial eradication, with minimum side effects.(6) apdt involves using visible light with an appropriate wavelength to kill microorganisms with a photosensitizing drug.(7) apdt could be an adjunctive aid to mechanical debridement in eliminating key periodontal pathogens. this therapy was specified as an oxygen-dependent photochemical reaction upon light-mediated activation of photosensitizing materials leading to cytotoxic reactive oxygen species (ros) generation, predominantly singlet oxygen.(8) the activity of apdt is dependent on the combination of a non-toxic photosensitizer and a specific wavelength of visible light, which is activated and can promote a phototoxic response in the presence of ambient oxygen.(9) apdt is characterized by ros generation by pss in response to photo illumination, which later causes cell death.(6)

Eligibility criteria:
inclusion criteria: * each patient should have at least four teeth with a probing depth ≥of 5mm. * patients with good domestic oral hygiene will be include (documented with a full mouth plaque index of ≤ 30% before starting the clinical trial) exclusion criteria: * patients receiving periodontal therapy and/or antibiotics within the previous six months * patients with diseases or medication with an inhibitory or promoting effect on periodontal healing, including anticoagulants, anti-inflammatories. * pregnant or nursing women * patients allergic to the test product will be excluded.

Keywords: probing pocket depth phhotosensitizers
knowledge, attitudes and clinical practices of pediatric dentists regarding covid-19

Conditions: COVID-19

Summary: this study aims to assess the level of knowledge, attitudes and clinical practices of pediatric dentists regarding covid-19 pandemic outbreak and evaluate the psychological burden on the dentists and children

aim: this cross sectional study aims to assess the level of knowledge, attitudes and clinical practices of pediatric dentists regarding covid-19 pandemic outbreak and evaluate the psychological burden on the dentists and children. the study population is pediatric dentists recruited through five pediatric dentists facebook groups. web-based questionnaire was created using google forms, structured of multiple-choice questionnaire, and divided into: (demographic, knowledge, practices, and behavior management techniques) sections. descriptive statistical analysis was used to describe items included in the survey. numbers and percentages were used to describe categorical data.

Eligibility criteria:
inclusion criteria: practicing pediatric dentists working in private practices or institutions exclusion criteria dentists specialized in other disciplins

Keywords: covid-19 pediatric dentists attitudes clinical practices