Kornimate/medical-research-clean huggingface dataset:
surgical field bacterial contamination in primary total hip (tha) and knee (tka) arthroplasty

Conditions: Prosthetic Infections

Summary: in denmark, approximately 13,000 operations are carried out every year. prosthetic infection is a very serious condition and despite extensive prophylactic measures, prosthetic infections appear in 1-2 percent of the operated patients. it is difficult to diagnose prosthetic infection with the techniques applied so far and incorrect diagnosis might imply unnecessary reoperations as well as unnoticed infections might lead to prolonged pain and invalidity. the purpose of this study is to examine the value of these three techniques applied as a supplement to the existing technology and on this basis to prepare an algorithm for the examination of joint prosthesis infection.


Eligibility criteria:
inclusion criteria: * patients who have been through an alloplastic operation in hip og knee. exclusion criteria: * patients with cancer or a bilateral disease * former patients who have been through an operation with implants in hip or knee. * patients who might be infected in the joint due to operation in hip or knee. * lack of informed consent or inability to read/understand danish

Keywords: contamination, hip operation, knee operation
clock genes in patients with refractory septic shock (septiclock) - pilot study

Conditions: Septic Shock

Summary: despite large efforts trying to improve diagnostic and therapy of sepsis have been made over the last decade (e.g. initiation of the surviving sepsis campaign, defining evidence based sepsis therapy bundles) the mortality of septic shock remains high and causes high socioeconomical burden of disease. the purpose of this pilot study is to evaluate the design and conduct of a projected full scale clinical trial.

a functional clock is required for induction of several proinflammatory genes, not shown in septic patient settings, yet. clock genes are involved in modulating the activity of several transcription factors that are important regulators of immune functions (e.g. hif1-α, stat1, stat3, and nf-κb) (bellet mm et al., 2013). furthermore, polymorphisms such as rs7221412, a common polymorphism near period homolog 1 (per1), was associated with the timing of activity rhythms and also showed a suggestive time-dependent relationship with both cerebral cortex and monocytes per1 expression and an association with time of death (lim asp et al., 2012). this explorative project is a pilot study. first data are generated for the assessment of the circadian system in patients with septic shock.

Eligibility criteria:
inclusion criteria: * male and female patients with age 18 years and above, * patient at intensive care units (8i, 9i and 1i at charité - university medicine berlin , campus virchow- klinikum), * septic shock (accp/sccm (american college of chest physicians/society of critical care medicine) consensus definitions) and norepinephrine dosage of \>0.3 μg/kg/min for at least 2 hours exclusion criteria: * pregnant or lactating female patient, * participation in another interventional study (30 days before study inclusion and during study participation), * acute leucemia, * severe leukocytosis (\>50,000/nl), * severe thrombocytopenia (\<5,000/nl), * autoimmune disease with systemic medication of ≥10 mg prednisolone equivalent or previous transplantation, * patients receiving interferon therapy (last 14 days), * patients with known hypersensitivity gm-csf or known antibodies against gm-csf, yeast-derived products or any component of the study medication, * ongoing (concomitant) chemotherapy or radiotherapy for malignancy, * acute pulmonary embolism or acute myocardial infarction within last 72 hours, * cardiopulmonary resuscitation within last 7 days, * moribund patient (life expectancy \<72 hrs.), * presence of a do-not-resuscitate or do-not-intubate order, * known human immunodeficiency virus (hiv) infection or chronic viral hepatitis * lacking willingness to save and hand out data within the study * accommodation in an institution due to an official or judicial order * the informed consent of the patient or the subject's legally acceptable representative can´t be obtained in time * patient has a power of attorney or patient's provision, where he/she refuses participation in any clinical trial

Keywords: clock genes, circadian regulation
viral specific t-cells for treatment of viral infections after solid organ transplant

Conditions: Solid Organ Transplant; Viral Infection

Summary: the purpose of this research study is to learn more about the use of viral specific t-lymphocytes (vsts) to treat viral infections that may happen after solid organ transplant (sot). vsts are cells specially designed to fight viral infections that may happen after a solid organ transplant. these cells are created from a blood sample collected from the study participant. solid organ transplant and the use of immunosuppressive medications reduces the body's ability to fight infections. viral infections are a common problem after transplant and can cause significant complications. reduction of immunosuppression may put the organ at risk of rejection. moreover, treatment of viral infections is expensive and time consuming, with families often administering prolonged treatments with intravenous anti-viral medications, or patients requiring prolonged admissions to the hospital. the medicines can also have side effects like damage to the kidneys or reduction in the blood counts, so in this study the investigators are trying to find a better way to treat these infections and minimize complications.


Eligibility criteria:
inclusion criteria: * blood adenovirus pcr ≥1,000 * blood cmv pcr ≥ 500 * blood ebv pcr ≥ 1,000 * plasma bkv pcr \>1,000 * plasma jc virus pcr \> 1,000 * evidence of invasive adenovirus infection. adenovirus infection will be defined as the presence of adenoviral positivity as detected by pcr or culture from one site such as stool or blood or urine or nasopharynx. adenovirus disease will be defined as the presence of adenoviral positivity as detected by culture or pcr from more than 2 sites such as stool or blood or urine or nasopharynx. * evidence of invasive cmv infection, e.g. pneumonitis, retinitis, colitis. * evidence of ebv-associated lymphoproliferation (ebv-lpd) defined as proven ebv-lpd by biopsy or probable ebv-lpd defined as an elevated ebv dna level in the blood associated with clinical symptoms (adenopathy or fever or masses on imaging) but without biopsy confirmation. * evidence of symptomatic bk virus infection, which may include symptomatic hemorrhagic cystitis, bk viruria or bk nephropathy * evidence of pml or other cns infection due to jc virus * clinical status must allow tapering of steroids to \< 0.5mg/kg prednisone or other steroid equivalent, or a clinically acceptable steroid dose at the discretion of the pi * age \> 1 day * must be able to receive vst infusion in cincinnati exclusion criteria: * uncontrolled bacterial or fungal infection
examining the effectiveness of a wait list intervention for the management of adolescent eating disorders

Conditions: Eating Disorders

Summary: the current application targets patient education and enablement, implementation of best practices, continuity of care, and an improvement model to improve efficiencies by investigating whether a brief targeted intervention prior to the first formal ed assessment is efficacious in altering outcome and treatment course.

the eating disorder program at the children's hospital of eastern ontario (cheo) offers a continuum of treatment options to child and adolescent patients with eating disorders (eds). although our own funding has increased in recent years, so too have the number of referrals, which has resulted in lengthy wait times for therapeutic assessments by our team. the current application targets patient education and enablement, implementation of best practices, continuity of care, and an improvement model to improve efficiencies by investigating whether a brief targeted intervention prior to the first formal ed assessment is efficacious in altering outcome and treatment course. it is well known that early recognition and implementation of treatment as soon as possible after the onset of symptoms is protective in eating disorders and leads to better success rates and recovery (apa treatment guidelines for eds). it is hoped that the outcome of this study will influence the way in which centers look to address the ongoing issue of lengthy wait times in hopes of offering cost-effective interventions that ultimately improve patient outcomes. by offering an added level of support to families whose referral has been initiated, we hope to ease the burden of primary care providers and increase their satisfaction as it relates to patient safety concerns and complex case management.

Eligibility criteria:
inclusion criteria: * medical stability at time of referral * completed referral to the eating disorders program exclusion criteria: * patients deemed medically unstable are triaged urgently and not eligible for study inclusion

Keywords: anorexia nervosa bulimia nervosa ednos
diagnosis of endocrine dysfunctions in covid-19

Conditions: Covid 19

Summary: as observed with sars-cov responsible for sars 2003, the new coronarovirus sars-cov-2 uses the angiotensin converting enzyme type 2 (ace2) as cellular receptor to infect cells. the renin aldosterone angiostensin system (raas) has known effects in the lungs: some receptors are pro-inflammatory, others are anti-inflammatory. thus the deregulation of the raas induced by the sars-cov-2 could explain the inflammatory response of covid-19 infection and be a modulator of the severity of its course. furthermore, the sars 2003 experience suggests that there may be others endocrine involvment, particularly an failure on the hypothalamus-pituitary and adrenal axis. indeeed, cases of hypocorticism and hypothyroidism of central origin were described. altogether, the endocrine system might play a role both in the pathophysiology of covid-19 infection and in the activity and severity of the disease. in this study, the investigators proposed to explore endocrine functions on biological samples in a series of patients admitted for covid-19 in our clinic.


Eligibility criteria:
inclusion criteria: - patients with covid-19 diagnosis and hospitalized in our clinic exclusion criteria: - minor patient

Keywords: covid-19 renin angiotensin aldosterone system hormon disorders
monitoring patterns of prescribing to identify changes in access to er/la opioid analgesics

Conditions: Opioid Related Disorders; Opiate Addiction; Narcotic Abuse; Drug Abuse

Summary: changes in prescribing will be compared in prescribers from specialties whose prescribing is hypothesized to be relatively unaffected by the rems (such as oncologists and hospice providers) versus those for whom the rems could have greater impact on prescribing (e.g., dentists). trends and changes in monthly prescription volume and average monthly prescription volume will be evaluated by prescriber specialty.


Eligibility criteria:
inclusion criteria: * changes in number of prescriptions for prescriber types with less or more compelling reasons to prescriber er/la opioid analgesics exclusion criteria: * none
swedish adjustable gastric banding observational cohort study

Conditions: Obesity, Morbid

Summary: longitudinal prospective cohort study of patients treated consecutively by sagb in a sample of centers representative of this activity in france. verification by means of a screening log (exhaustive list of all bariatric procedures performed by participating surgeons between the beginning and end of the cohort inclusion period) requested from all centers. no comparator group. no randomization or blinding techniques

longitudinal prospective cohort study of patients treated consecutively by sagb in a sample of centers representative of this activity in france. the study is originated in collaboration with has in france and has a target of 500 patients treated with gastric banding because of morbid obesity.

Eligibility criteria:
inclusion criteria: * morbidly obese patients (bmi\>35 with comorbidities or bmi\>40 without comorbidities) in france selected for gastric banding based on standard local clinical practice exclusion criteria: * lower bmi, contraindications based on local clinical assessment
vancomycin reduction practices (vrp) in the nicu

Conditions: Antibiotic Stewardship; Neonatal Sepsis, Late-Onset; Vancomycin

Summary: this multi-center, cluster randomized study aimed at improving implementation of vancomycin reducing practices (vrp) in neonatal intensive care units (nicus). sites will be recruited and randomized to receive either external facilitation or no external facilitation to assess the effect on center-level fidelity to the core components of vrp implementation. interventions available to both study arms are directed at hospital staff and includes identification of local champions, educational outreach, unit-level audit \& feedback, and use of a clinical decision support tool.


Eligibility criteria:
inclusion criteria: * level iii nicu * affiliated with kaiser permanente northern california (kpnc) or children's hospital of philadelphia newborn care network (cnbcn) * recruited by study team exclusion criteria: * site not recruited for the study

Keywords: implementation study
trial of sinphar lipucan capsule to regulate immune function

Conditions: Nutrition, Healthy

Summary: trial of sinphar lipucan capsule to regulate immune function

the immune system is the line of defense for the health of human life entities. if the function decrease, it will reduce the body's defense to outside pathogen and easily lead to the occurrence of diseases. immune response includes two kinds of reactions: (1) the innate immune system refers to inherited, germ-line defense mechanisms that are directed against molecular components found only in micro-organisms.. (2) the humoral immune response denotes immunologic responses that are mediated by antibodies. health hazards have always been a trend based on health awareness. therefore, how to use a healthy diet to promote the immune system is currently the most concerned research direction. because of the immunomodulatory effect of " sinphar lipucan capsule " in previous animal experiments (1) promote the secretion of th1 type cytokine by t cells and inhibit the secretion of th2 type cytokine; 2) promote the secretion of ifn-γ by macrophages. 3) promote the production of ova antigen-specific antibodies in balb/c female mice; 4) it can inhibit the secretion of il-10 cytokine by antigen-specific (ova) immune cells (that is, inhibit the secretion of th2 cytokine), we think " sinphar lipucan capsule " may be beneficial in reducing the severity and incidence of acute upper respiratory tract infection. therefore, human clinical trials were started to confirm its clinical effects and immunomodulatory effects.

Eligibility criteria:
inclusion criteria: - healthy volunteers exclusion criteria: 1. evidence of chronic cardio-pulmonary disease, immune-suppression or any chronic systemic disease or disability 2. positive pregnancy test or currently breastfeeding 3. history of autoimmune disease 4. history of allergic rhinitis 5. history of physician diagnosed eczema 6. known allergic reaction to poria cocos or related species, 7. pregnancy or currently breastfeeding. 8. history of autoimmune disease or immune disorders. 9. history of asthma. 10. history of allergic rhinitis.

Keywords: lipucan immune acute upper respiratory tract infection
risk stratification value of biomarkers in patients with ventricular arrhythmias

Conditions: Ventricular Arrythmia

Summary: the investigation of biomarkers for immune status and metabolic state, as well as host microbiota composition, in patients with ventricular arrhythmias before and after radiofrequency ablation, can provide new insights for specific and personalized treatment. this can help establish early prediction and prognosis models and provide a basis for clinically effective diagnosis and treatment.

abnormal immune and metabolic states can lead to the occurrence of various systemic diseases, including the development of cardiovascular diseases through multiple mechanisms. on the other hand, various diseases can also feedback and regulate the immune and metabolic systems. however, currently there is no research on the impact of immune and metabolic states on ventricular arrhythmia. exploring the biomarker characteristics and risk stratification of patients with ventricular arrhythmias undergoing radiofrequency ablation before and after the procedure can provide new insights for specific and personalized treatment. it can establish early prediction and prognostic models, providing evidence for clinically effective diagnosis and treatment.

Eligibility criteria:
inclusion criteria: * patients with ventricular premature beats, ventricular tachycardia, or ventricular fibrillation detected by regular surface twelve-lead electrocardiogram or holter. exclusion criteria: * age \ 80 years old; * patients with autoimmune diseases or immune deficiencies, or those who have used immunosuppressive or immune modulating agents in the past 3 months; * platelet count \<100×10\^9/l or functional platelet defects; * congenital or acquired coagulation or bleeding disorders; * patients with a history of organ transplantation or are preparing to receive organ transplantation; * unwilling to sign an informed consent or cooperate with the examination.

Keywords: ventricular arrhythmia prognosis
staged bilateral percutaneous nephrolithotomy

Conditions: Stone, Kidney; Urolithiasis

Summary: to determine the optimal time between the first and second operations in patients with bilateral kidney stones and scheduled percutaneous nephrolithotomy for the contralateral kidney. patients who underwent percutaneous nephrolithotomy to the contralateral kidney 2-4 weeks and 4-6 weeks after the first operation will be compared.

the aim of the study is to determine the optimal time between the first and second operations in patients with bilateral kidney stones and scheduled percutaneous nephrolithotomy for the contralateral kidney. in our study, patients who underwent percutaneous nephrolithotomy to the contralateral kidney 2-4 weeks and 4-6 weeks after the first operation will be compared. with the guidance of preoperative and postoperative data, it is aimed to determine the optimal time with the lowest complication and highest operational success.

Eligibility criteria:
inclusion criteria: * patients with stones of 2 cm or more in each kidney exclusion criteria: * renal failure * coagulopathy * pregnancy
miclasp post market clinical follow-up (pmcf) study

Conditions: Mitral Regurgitation; Mitral Insufficiency

Summary: this is a postmarket clinical follow up study on the safety and effectiveness of the edwards pascal transcatheter valve repair system and the edwards pascal precision transcatheter valve repair system in transcatheter mitral valve repair.

the objectives of this clinical study are to collect data on the safety of the edwards pascal transcatheter valve repair system and the edwards pascal precision transcatheter valve repair system in transcatheter mitral valve repair and on the effectiveness of the edwards pascal system and edwards pascal precision system in improving mr, functional status and quality of life in a post market setting.

Eligibility criteria:
inclusion criteria: 1. mitral teer patients eligible per the current approved indication after heart team discussion and agreement 2. patient is willing and able to attend all follow-up visits and to perform all tests 3. provision of written informed consent exclusion criteria: 1. patients are not eligible per the current instructions for use 2. non-elective or emergency teer procedure for mitral regurgitation 3. patients in icu prior to the index procedure
school centered telemedicine program for children with type 1 diabetes mellitus

Conditions: Type 1 Diabetes

Summary: the purpose of this study is to determine if using school-based telemedicine for diabetes support and education in students with type 1 diabetes in grades k-8 can lead to improvement in control of diabetes and improved satisfaction of all caregivers.

subjects, ages 5 to 14 years (grades kindergarten through eighth) were randomized to usual care (18 students; 13 schools) or intervention (23 students; 12 schools). usual care included medical visits every 3 months and communication between school nurse and diabetes team as needed by phone. the intervention group received usual care plus a telemedicine unit in the school nurse office to videoconference between the school nurse, child, and diabetes team every month. hemoglobin a1c and pediatric quality of life were measured every 3 months for 1 year. analyses used multilevel modeling.

Eligibility criteria:
inclusion criteria: * type 1 diabetes under care of joslin diabetes center in syracuse ny * grade k-8 * age 5-14 at time of enrollment * consent of student, parent and school
identify micrornas in cachexia in pancreatic carcinoma

Conditions: Resectable Pancreatic Adenocarcinoma

Summary: the purpose of this study is to determine the proportion of pancreatic patients who experience weight loss and cachexia, and to identify any differences in the genes between patient groups.

this research study will retrospectively examine 1395 patients from the university of alabama and the university of oklahoma stephenson cancer center (ou-scc) pancreatic cancer cohorts. the prospective arm, will enroll a total of 100 eligible volunteers at the ou-scc. the demographic and medical data from the retrospective and prospective arms will be combined (1495 patients) to ascertain any racial disparities in pancreatic cancer patients with cachexia. perspective volunteers at the ou-scc will undergo routine tests to determine if their cancer is operable. pancreatic tumors will be removed from the eligible patients, as part of their normal standard of care and will be examined for genes that may be related to unexplained muscle loss and compared to tumor tissue from other patients with pancreatic cancer. an optional hand strength exam, and standing on a scale that measures weight, muscle, and body fat will be available to ou-scc patients.

Eligibility criteria:
inclusion criteria: 1. male or female patient, who is ≥ 18 years old at the time of informed consent. 2. patients with operable pancreatic tumors diagnosed in the last 12 months prior to consent with clinical discretion or pathology confirmed as adenocarcinoma. 3. patient has stage i or higher disease who is considered a candidate for surgical resection of pancreatic cancer, with or without neoadjuvant chemotherapy. 4. ability to provide written informed consent and hipaa authorization. exclusion criteria: 1. patients with pancreatic adenocarcinoma who do not meet the criteria for surgical resection. 2. patient has cancer diagnosis other than primary pancreatic adenocarcinoma.

Keywords: pancreatic cancer cachexia microrna mrna pdac