Kornimate/medical-research-clean huggingface dataset:
vestibular rehabilitation in patients with vestibular migraine

Conditions: Vestibular Migraine; Vestibular Disorder; Migraine Variant

Summary: abstract: introduction: vestibular migraine(vm) is a disease that manifests with episodic vertigo attacks in patients with or without migraine type headaches, when present accompanying the headaches. its prevalence was found out as %1 in a study in germany. it usually involves middle aged women. vm can make a huge impact on quality of life, therefore advances in its diagnosis and management are valuable. while pharmacotherapy that is being used in migraine can be beneficial, vestibular rehabilitation(vr) programmes are predicted to be one of the most important types of treatment in management of vm. this study compares the results of pharmacological management options and vestibular rehabilitation programmes in the context of dizziness, balance problems and headache. material and methods: 77 patients with vm were included in study, and 60 of them completed it. while one group took only vr programme, and another took only pharmacological prophylaxis. the third group took a combined therapy, and the groups were consisted of 20 patients. patients were assessed with caloric tests, audiometric studies, static posturography, dizziness handicap inventory(dhi), and activities specific balance confidence(abc) scales. all of the assessments were applied 3 times throughout the study, and the results were compared with relevant statistical tests.


Eligibility criteria:
inclusion criteria: * 1-vestibular migraine diagnosis according to international classification of headache disorders (3 rd edition-beta version) 2- no history of vestibular rehabilitation or exercises exclusion criteria: * history of psychiatric disorder which might interfere with compliance to study * other diagnosis that might possibly cause vestibular disorder(cerebellar disorders, meniere disease etc) * anatomical defects of the inner ear or vestibular system * patients who are unable to stand up straight or walk
a study to evaluate pk, efficacy, and safety of bat3306 plus chemo and compare with keytruda®(eu/us) in participants with iv nqnsclc

Conditions: Carcinoma, Non-Small-Cell Lung

Summary: to compare the pairwise pk similarities between bat3306, eu-keytruda, and us-keytruda, all administered with pemetrexed and carboplatin.

this is a multi-center, double-blind, randomized study that includes pk and clinical equivalence comparisons, aimed at comparing bat3306 with keytruda® in previously untreated participants with stage iv nsnsclc.

Eligibility criteria:
inclusion criteria: * participants are eligible to be included in the study only if all the following criteria are met: 1. male or female, age ≥18 years on the day of signing informed consent. 2. participants are able to give voluntary informed consent and understand the study and are willing to follow and complete all the test procedures. 3. life expectancy ≥3 months, per the investigator's evaluation. 4. eastern cooperative oncology group (ecog) performance status ≤1. 5. histologically/cytologically confirmed diagnosis of stage iv (ajcc 8th edition) nsnsclc. 6. tumors without egfr mutation/ros1 rearrangement /alk rearrangement. exclusion criteria: * participant must be excluded from participating in the study if the participant: 1. is pregnant or a nursing female. 2. has predominantly squamous cell histology nsclc. mixed tumors will be categorized by the predominant cell type; if small cell elements are present, the participant is ineligible. 3. is currently participating and receiving an investigational agent or has participated in a study of an investigational agent and received an investigational agent or used an investigational device within 4 weeks prior to administration of the first dose of study intervention. 4. before the first dose of study intervention: * had received prior systemic antineoplastic chemotherapy and targeted, biological therapy * had prior treatment with any other anti-pd-1, pd-l1 or pd-l2 agent or an antibody targeting other immuno-regulatory receptors or mechanisms. examples of such antibodies include (but are not limited to) antibodies against tigit, ido, pd-l1, ctla-4, and lag3. * has participated in any other bat3306 study and has been treated with bat3306. * had major surgery \<3 weeks prior to first dose * received radiation therapy to the lung that is \> 30 gy within 6 months of the first dose of study intervention. * completed palliative radiotherapy within 14 days of the first dose of study intervention. 5. is expected to require any other form of antineoplastic therapy while participating in the study. and so on
efficacy and safety of endovascular thrombectomy in acute ischemic stroke with posterior circulation large infarct

Conditions: Acute Basilar Artery Occlusion; Posterior Circulation Large Infarct

Summary: the purpose of this study is to evaluate whether endovascular thrombectomy (evt) combined with best medical management (bmm) leads to better functional outcomes than bmm alone in patients with acute basilar artery occlusion with posterior circulation large infarct.

this study is a multicenter, prospective, cohort study that prospectively enrolled consecutive patients with acute basilar artery occlusion and large core infarction in the posterior circulation, confirmed by imaging (cta/mra/dsa). written informed consent was obtained from all participants or their legal representatives prior to enrollment. patients were divided into the best medical management (bmm) group and the endovascular thrombectomy (evt) group according to the treatment they received. this study adhered to the strengthening the reporting of observational studies in epidemiology (strobe) guidelines.

Eligibility criteria:
inclusion criteria: 1. age 18-80 years old; 2. acute ischemic stroke in the posterior circulation, the onset of stroke (or last well known) to the enrollment time within 24 hours; 3. cta/mra/dsa confirmed acute basilar artery occlusion; 4. posterior circulation large infarct: ncct or dwi showed pc-aspects ≤ 5 points, or pontine midbrain index (pmi) ≥ 3 points; 5. nihss score ≥10 points after the onset of the stroke and before enrollment; 6. able to live independently before the onset of the disease (mrs score ≤2 points); 7. the subject or legal representative is able to sign the informed consent form. exclusion criteria: 1. intracranial hemorrhage (except microhemorrhage) on ct/mri ; 2. ct/mri revealed large infarction in the cerebellar hemisphere, with significant mass effect causing compression of the fourth ventricle or brainstem; 3. ct or mri showed bilateral complete thalamic infarction; 4. occlusion of anterior and posterior circulation arteries confirmed by cta/mra/dsa; 5. the presence of intracranial tumors (except for small meningiomas and cerebral aneurysms with a diameter of \<3mm); 6. patients with known or highly suspected chronic basilar artery occlusion.; 7. known severe allergy to contrast agents (except for mild rash); 8. refractory hypertension (defined as systolic blood pressure \> 185 mmhg or diastolic blood pressure \>110 mmhg) that cannot be controlled by drug therapy; 9. known pregnant or lactating females, or positive pregnancy test before enrollment; 10. acute cerebral infarction within 48 hours after cardiovascular and cerebrovascular intervention or major surgery (patients more than 48 hours can be enrolled).
mucormycosis in icu

Conditions: Mucormycosis

Summary: mucormycosis is an invasive fungal infection affecting patients with various clinical conditions especially patients with heavy immunosuppression or patients with trauma or extensive burns. zygoréa is a retrospective and multicentric french study aimed to evaluate survival of patients with mucormycosis admitted in icu at day-28 after admission. this study will also try also to describe the epidemiology of patients admitted in icu.

mucormycosis is an invasive fungal infection affecting patients with various clinical conditions especially patients with heavy immunosuppression or patients with trauma or extensive burns. the incidence of mucormycosis is currently increasing reaching 7% of invasive fungal infections in some immunocompromised patients. because of its aggressive nature, mucormycosis is associated with poor survival and high morbidity ; mortality is estimated between 16% and 64% according to different retrospective studies. no study has ever evaluated prognosis of patients with mucormycosis admitted in intensive care units (icu). zygoréa is a retrospective and multicentric french study aimed to evaluate survival of patients with mucormycosis admitted in icu at day-28 after admission. this study will also try also to describe the epidemiology of patients admitted in icu and to evaluate the prognosis of different subgroups of patients according to : * their clinical characteristics : demographic characteristics, clinical conditions and factors of immunosuppression * the characteristics of the fungal infection * the treatment strategy * the severity of the initial illness, evaluated by severity scores twenty-one french icu are currently including more than 45 patients.

Eligibility criteria:
inclusion criteria: * confirmed or suspected mucormycosis, based on international definition from eortc/msg * patient hospitalized in intensive care unit during the 2008-2016 period * zygomycosis identification in at least 2 solids organs or identification in hemoculture exclusion criteria: * age under 18 years old * patient under the law

Keywords: mucormycosis intensive care medicine
eat, move, live program for the reduction of cancer and chronic disease risk in underserved communities

Conditions: Diabetes Mellitus; Obesity-Related Malignant Neoplasm

Summary: this clinical trial tests the eat, move, live (eml) program in reducing the risk of chronic diseases among underserved communities by improving healthy lifestyle practices, increasing physical activity and encouraging healthy eating behaviors. eml is a series of free culturally and linguistically appropriate nutrition and physical activity sessions. the interactive education segment of the eml program is culturally responsive, and based on the community eml program, and topics will include: nutrition guidelines, reading food labels, recipe modification and healthy food preparation, eating healthy on a budget, chronic diseases information and prevention strategies. the eml program may help reduce the risk of cancer and chronic diseases by encouraging more physical activity and healthy eating behaviors.

primary objectives: i. to evaluate program by assessing in combination with standard of care metformin: changes in participants' knowledge, attitudes, and behavior. ii. to evaluate program by assessing in combination with standard of care metformin: changes in body measurements. iii. to evaluate program by assessing in combination with standard of care metformin: changes in biomarkers. outline: participants attend eml program sessions weekly for 12 weeks including an educational session chronic disease risk reduction via nutrition and physical activity, a physical activity session, and a cooking/taste test demonstration.

Eligibility criteria:
inclusion criteria: * agrees to group consent at week 1 * age over 18 * able to speak and understand english and/or spanish exclusion criteria: * don't agree to group consent at week 1 * age younger than 18 * not able to speak and understand english and/or spanish * can't participate in physical activity
negative pressure ventilation imapcts weaning ventilator in medical intensive care units (icus)

Conditions: Respiratory Failure

Summary: this is a quasi-experimental research design. the subjects are limited in intensive care unit within north medical center hospital. all subjects depend on ventilator and receive weaning plans. experimental group is weaning with the support of negative pressure ventilator .the investigators collect basic personal variables in the questionnaire, apache ⅱ scale, dyspnea scale and arterial blood gas analysis and ventilator weaning index. compare experimental group and control group data. data will be statistical analyzed by: descriptive statistics (such as: mean, standard deviation, median, frequency, percentage) and inferential statistics (such as: independent t-test, pair t-test, mann-whitney u test), p-value \<0.05 will consider to be statistically significant.


Eligibility criteria:
inclusion criteria: * acute respiratory failure patients in medical icus exclusion criteria: * age\<20 years old * malignancy * pregnancy

Keywords: acute respiratory failure patients in medical icus.
pilot study to test the feasibility of the use of mri in suspected scaphoid fractures

Conditions: Scaphoid Fracture

Summary: this pilot study aims to test the feasibility and work flows associated with using mri as the initial imaging modality in the investigation of patients presenting with suspected scaphoid fracture. this pilot will be used to inform the design of a study that will aim to evaluate whether the proposed intervention is likely to generate cost-savings whilst improving or maintaining overall patient quality of life and satisfaction.

the present pilot study is designed to assess the feasibility of using mri as the initial imaging modality in the investigation of patients presenting with suspected scaphoid fracture at the emergency department or urgent care centre. this study will inform the design of a study that will aim to evaluate whether the proposed intervention is likely to generate cost-savings whilst improving or maintaining overall patient quality of life and satisfaction. patients with a suspected scaphoid fracture will be randomised to receive standard of care using 4-view plain x-ray (control group) as the first imaging modality or mri examination as the first imaging modality.

Eligibility criteria:
inclusion criteria: * patients considered to be suitable for the proposed pathway include every patient aged 16 years old or above, presenting at a\&e/ucc between 8:00am and 4:00pm (monday to friday), with at least one of the following: * isolated pain / tenderness over the anatomical snuff box (asb) or scaphoid tubercle or pain in the scaphoid region during axial loading of the 1st metacarpal. * history of recent fall (\< 14 days) on out-stretched hand (foosh), wrist injury or poor history associated with examination findings suggestive of scaphoid fracture. exclusion criteria: * patients presenting outside gstt's catchment area not willing to be followed-up at gstt; * patients without suspected scaphoid fracture following an initial a\&e/ucc clinical triage; * patients with scaphoid fracture not admitted through a\&e at st thomas' hospital or urgent care centre at guy's hospital; * patients presenting at ed/ucc on weekdays (monday to friday) before 8:00am or after 4:00pm * patients presenting at ed/ucc on weekends or bank holidays; * patients who lack capacity to give consent or participate in the study; * patients that are already taking part in a clinical trial of an investigational medicinal products (ctimps); * patient is unable or unsuitable to mri

Keywords: suspected scaphoid fracture
weight bearing for fibular fractures

Conditions: Fibula Fracture

Summary: it is common practice to restrict weight bearing after ankle fracture open reduction and internal fixation (orif) until week 6 postoperatively. however, controversy exists surrounding the optimal postoperative protocol. at our institution, all ankle fractures are made non-weight bearing for 6 weeks across the board. isolated lateral malleolar fractures after orif may benefit from earlier weight bearing in terms of patient satisfaction, short-term functionality, and return to work. the purpose of this study is to determine if early weight bearing at 2 weeks postoperatively for isolated lateral malleolar fractures leads to a higher satisfaction with surgery as compared to standard protocol for postoperative ankle fractures and better functional outcomes


Eligibility criteria:
inclusion criteria: * adult patients (age\>18) undergoing surgical treatment for isolated lateral malleolar fracture with foot and ankle surgeons at the rothman orthopaedic institute exclusion criteria: * patients requiring other fracture fixation, deltoid ligament repair, or syndesmosis fixation * revision ankle fracture cases * pre-existing impaired mobility, * pre-existing cognitive disability, * open fractures, * bmi \>40, * diabetes mellitus (dm)
cognitive impairment and cardiovascular risk in older

Conditions: Cognitive Impairment; Cardiovascular Risk Factor

Summary: the objective of this project is to study cognitive yields in people of the town of salamanca over 65, with particular emphasis on the acquisition of the initial symptoms of cognitive impairment in order to detect mild cognitive impairment and study the relationship between the clinical situation and cardiovascular risk factors. it will depart from a reference population of 420 people older than 65 years living in the municipality of salamanca which took part in a survey prior to partner health needs of the elderly of 65 years in the municipality of salamanca. this was a stratified sampling as stratum considering the area of health. the results of this study are expected to evidence the extent of the problem of cognitive decline in the population over 65 years. it is also expected to determine the relationship between the co-morbidity in this problem and specific factors of cardiovascular risk in this group of population.

a random sample population, the information obtained has a validity superior to other studies in which the sample has not followed very strict criteria of selection. protocol for measurement: * variable demographic partner * vascular risk factors * co-morbidity * functional level for the activities of daily life * cognitive performance in attention, memory, language, praxias, gnosias (abbreviated neuropsychological battery) through a battery short neuropsychological specially adapted for the study of older people will carry out a study of the cognitive performance in people older than 65 years of age and will try to establish how much influence the controlled variables of cardiovascular risk.

Eligibility criteria:
inclusion criteria: * lives in the municipality of salamanca * over 65 years of age

Keywords: dementia cardiovascular risk elderly aging older 65-100 years
safety study to lower the risk of heart failure is also effective in reducing stiffness of the arteries

Conditions: Hypertension; Diabetes

Summary: the study is being done to see if a drug shown to lower the risk of heart failure is also effective in reducing the stiffness of the arteries.

to determine the effect of nebivolol versus metoprolol in type 2 hypertensive diabetic patients on systolic blood pressure and diastolic blood pressure.

Eligibility criteria:
inclusion criteria: * established type 2 diabetic not treated with insulin * stage 1 hypertensives blood pressure \> 130/80 mmhg and \< 160/100 mmhg * bmi \< 35 * hemoglobin a1c \< 8.5 * must be postmenopausal or taking some form of birth control of surgically sterile exclusion criteria: * acute myocardial infarction, unstable angina, stroke or tia within the past year. * active angina in the last three months * diabetes requiring treatment with insulin * severe asthma * female who are pregnant, planning to be pregnant during the study period, lactating or women of childbearing potential who are not using a medically approved method of contraception * recent history of substance or alcohol abuse . * uncontrolled hypertension systolic blood pressure \>160mmhg or diastolic blood pressure \> 100 mmhg

Keywords: diabetes hypertension aortic impedance
dentist-patient communication on dental anxiety using the social media and timing in communication

Conditions: Dental Anxiety; Timing in Dentist-Patient Communication

Summary: scales application one week before and one week after impacted tooth extraction.

the purpose of the present study was to assess the effects of dentist-patient communication via social media on dental anxiety, and second, to evaluate the appropriate timing of such communications. instagram's quick replies system was used to answer patients' questions to alleviate dental anxiety for patients undergoing impacted mandibular third-molar extraction under local anesthesia. patients were assigned randomly into four groups according to timing of such communications: communication before operation (n=36), communication after operation (n=35), communication before and after operation (n=36), and a control group who received no communication on social media (n=36). dental anxiety was evaluated one week before and after the surgical operation using recognized assessment scales-the spielberger's state-trait anxiety inventory, modified dental anxiety scale and a visual analog scale.

Eligibility criteria:
inclusion criteria: * must be able to use the instagram platform. i * clinicial diagnosis of mesioangular impacted lower third molar according to the classification of winter and the pell and gregory classification (2 or 3/b). exclusion criteria: * patients who previously obtained information from social media * bad dental history * systemic disease * pregnant

Keywords: communication dental anxiety social media
rifaximin for preventing acute graft versus host disease (agvhd)

Conditions: Malignancy; Bone Marrow Transplantation

Summary: acute graft versus host disease is a frequent and often life threatening complication of allogeneic blood and marrow transplantation. the bacteria that normally reside in the intestine play a critical role in its development. injury to the lining of the bowel that results from the high dose chemotherapy or radiation that transplant patients receive during the week preceding the transplant allows the bacteria to invade the intestines and spread to nearby lymph nodes. this, in turn, causes inflammation which has been shown to promote gvhd. both pre-clinical and clinical research has demonstrated that oral antibiotics can prevent graft versus host disease by inhibiting these gut bacteria. rifaximin has several features that suggest it could be effective in preventing gvhd. rifaximin prophylaxis might also provide an added benefit by protecting highly immunocompromised transplant patients from severe bacterial infections. this pilot trial will allow the investigators to determine the feasibility of using rifaximin for prevention of gvhd and infection in patients undergoing allogeneic blood and marrow transplantation. the preliminary results will be used to plan a more definitive trial.


Eligibility criteria:
inclusion criteria: 1. patients must be at least 12 years old. 2. patients will be eligible regardless of their type of disease (malignant or non-malignant), type of donor (hla matched related, mismatched related or unrelated donors), type of hematopoietic cell source (unstimulated marrow, cytokine stimulated marrow, cytokine stimulated peripheral blood or umbilical cord blood), or gvhd prophylaxis. 3. patients must receive a myeloablative or moderately intensive reduced intensity (at least 8 mg/kg oral busulfan (or the equivalent iv dose), or at least 100 mg/m2 of melphalan , or at least 100 mg/kg of cyclophosphamide, or at least 500 cgy of tbi) conditioning regimen. exclusion criteria: 1. age under 12 years. 2. known hypersensitivity to rifaximin, or other rifamycin antimicrobial agents. 3. minimally toxic conditioning regimen (e.g. low dose tbi based). since these regimens induce minimal myelosuppression and gut injury, patients receiving them probably stand little to gain from antibiotic prophylaxis. 4. patients with documented severe active infection (viral, bacterial, fungal, protozoal) will not be eligible. 5. patients with treatment unresponsive hematologic malignant diseases (based on an assessment done within two weeks of the start of conditioning therapy).

Keywords: rifaximin acute graft versus host disease bone marrow transplant non-malignancy requiring bmt