Kornimate/medical-research-clean huggingface dataset:
cognitive function in adults with cardiac disease

Conditions: Cognitive Impairment; Cardiac Disease

Summary: the purpose of this study is to identify cardiac patients' degree of unappreciated mild impairment in cognitive function patterns of cognitive function, and influencing factors related to cognitive functioning during hospitalization. the results from the study will contribute to tailoring the delivery of patient education to optimize patient understanding of information in future clinical practice. it is hypothesized that the study will demonstrate the following: 1. the degree of cognitive function for patients hospitalized in a cicu will be below the scores for normal functioning adults. 2. patients with acute cardiovascular conditions will score differently in cognitive functioning at various times throughout their hospitalization. 3. relationships between cognitive function and following variables: * patients with greater sleep deprivation or fatigue will exhibit lower cognitive functioning. * patients with greater hunger will exhibit lower cognitive functioning. * patients who are experiencing greater anxiety will exhibit lower cognitive functioning. * patients who are experiencing depression will exhibit lower cognitive functioning. * patients who have undergone or will undergo shortly treatment or procedures will exhibit lower cognitive functioning.


Eligibility criteria:
inclusion criteria: * admission to the cardiac intensive care unite for acute cardiological issues during time of enrollment. * patients with nyha class i, ii, iii, and iv. * 18 years or older and must be awake and conversant at time of enrollment. exclusion criteria: * history of neurological disorder or injury (e.g., alzheimer's disease, dementia, stroke, seizures). * moderate or severe head injury (defined as \> 24 hours loss of consciousness) * past or current history of severe psychiatric illness. specifically, psychotic disorders (e.g., schizophrenia) and bipolar disorder. potential participants will not be excluded on the basis of managed depression or anxiety disorder. these conditions are common in cardiac patients and their exclusion may limit the generalizability of findings. * 5 years past or current history of alcohol or drug abuse (defined by dsm-iv criteria). * history of learning disorder or developmental disability (defined by dsm-iv criteria). * renal failure requiring dialysis. * history of sleep apnea (defined through previous sleep studies). * severely ill individuals, including those who are sedated, on a ventilator, exhibiting acute hemodynamic changes, and/or those deemed inappropriate by patient's physician to participate in study.

Keywords: cognitive function cognitive impairment hospitalization cardiac disease
effects of physical activity on disease risk factors

Conditions: Childhood Obesity

Summary: obesity is associated with increased risk of heart disease and diabetes (kim et al., 2010). appalachian children in athens county, ohio, experience higher rates of obesity compared to the national average (20.9% vs. 15.4%), which increases their risk of obesity-related diseases (montgomery-reagan, bianco, heh, rettos, \& huston, 2009). although physical activity (pa) is known to improve fitness and adiposity (gutin \& owens, 2011; yin et al., 2009), very little is known about the effects of pa on the progression of chronic disease risk factors (biomarkers) for obesity-related diseases in children, such as inflammatory markers, lipids, and glucose/insulin. this lack of knowledge is due to a limited understanding of the number of calories burned during children's free-play pa. this study will assess the impact of a pa program (act) of known energy cost on obesity-related disease markers in 2nd-4th grade children compared to a sedentary control group (sed). the study will recruit children from an after-school program in athens county elementary schools. baseline and posttest data will include measures of height, weight, body composition, blood pressure, and physical activity levels. following baseline measures, children will be randomized into either the act or sed group for 8 weeks. the act group will play recess-type games previously determined to expend ≥100 calories in 30 minutes. the sed group children will play sedentary-type activities during the same time period. it is hypothesized that the act group children will demonstrate significant improvements in pa after 8 weeks compared to the sed group children and that these improvements will be related to positive changes in body weight and body composition.


Eligibility criteria:
inclusion criteria: * attends participating after school program exclusion criteria: * cardiorespiratory, metabolic, and neurological disorders and physical impairments that would prevent them from being physically active, and were not taking any medications that would affect metabolism
breast-conserving surgery techniques in treating women with breast cancer

Conditions: Breast Cancer

Summary: rationale: breast-conserving surgery is a less invasive type of surgery for breast cancer and may have fewer side effects and improve recovery. purpose: this phase ii trial is studying different breast-conserving surgery techniques in treating women with breast cancer.

objectives: primary * evaluate the percentage of histologically healthy margins maintained during resection in women with breast cancer. secondary * evaluate local recurrence at 5 years. * evaluate aesthetic results. * evaluate quality of life using the qlqc30 and br23 questionnaires. outline: this is a multicenter study. patients undergo oncoplastic conservative surgery according to defined modalities across the various centers. quality of life is assessed periodically. after completion of study treatment, patients are followed every 6 months for 2 years and then for at least 3 years.

Eligibility criteria:
disease characteristics: * meets 1 of the following criteria: * diagnosis of intraductal breast cancer requiring a wide local resection * diagnosis of infiltrating ductal breast cancer within range * diagnosis of invasive breast cancer that has not responded well to neoadjuvant treatment * no multicentric tumor * no gigantomastia * hormone receptor status not specified patient characteristics: * menopausal status not specified * no patients subject to a measure of legal protection or unable to express consent * no patients deprived of liberty by judicial or administrative decision or hospitalized without patient consent * not pregnant or nursing prior concurrent therapy: * no prior radiotherapy to the diseased breast * no prior adjuvant treatment * no concurrent participation in another clinical research study

Keywords: stage ia breast cancer stage ib breast cancer stage ii breast cancer stage iiia breast cancer stage iiic breast cancer ductal breast carcinoma invasive ductal breast carcinoma
using propranolol in traumatic brain injury to reduce sympathetic storm phenomenon

Conditions: Traumatic Brain Injury

Summary: traumatic brain injury (tbi) is one of the leading causes of death. severe tbt is correlated with an exaggerated stress response due to plasma catecholamine levels known as sympathetic storming. it is also autonomic dysfunction syndrome. this phenomenon is also associated with brain tumors, severe hydrocephalus and subarachnoid hemorrhage. patients are presented by tachycardia, tachypnea hypertension, diaphoresis, dystonia, hyperthermia, and dilated pupils with elevated levels of plasma catecholamine and blood glucose .

the sympathetic storming events can be triggered by suctioning, repositioning, or environmental stimuli. to differentiate sympathetic storming from similar conditions, symptoms and signs have to occur in tbi patients a minimum of 1 cycle per day for 3 consecutive days (body temperature of 38.5 °c or more, heart rate at least 120 beat / min, systolic blood pressure \> 140 mmhg, respiratory rate \> 20 breaths / min, in presence of dystonia, diaphoresis, agitation and laboratory investigations confirm elevated serum catecholamines. beta blockers has a cardio protective effect via lowering heart rate, stroke volume and mean arterial blood pressure which limits myocardial o2 consumptions and guards against myocardial infarction. they also have neuron protective effects via reducing cerebral blood flow thus lowering o2 and glucose consumption as cerebral metabolism is reduced. propranolol a nonselective b receptor antagonists works on β1 receptors in brain, heart, and kidney and β 2 receptors in lungs, liver, skeletal muscles, eye and arterioles.we suppose that using beta - adrenergic receptor blockers as propranolol blunts the sympathetic storming phenomenon as it is a nonselective β inhibitor and has a lipophilic property which enables it to penetrate blood brain barrier.

Eligibility criteria:
inclusion criteria: * patients with isolated blunt tbi * from 18 to 60 years old both sex * not in need of mechanical ventilation * gcs on admission between 9 and 12 * rotterdam ct score from 2-4. * normal procalcitonin test to exclude infection. exclusion criteria: * preexisting heart disease * myocardial injury * craniotomy * preexisting cerebral dysfunction * spinal cord injury * diabetes mellitus * severe liver or kidney disease * patients with sepsis
t1rho mri evaluation of patellofemoral changes after tibial im nailing

Conditions: Acute Tibial Fracture Requiring Intramedullary Nailing

Summary: this study will utilize t1-rho mri to evaluate the effect of intramedullary nailing on patellofemoral articular cartilage when the surgery is performed using the infrapatellar vs. the suprapatellar approach. subjects will be randomized to one or the other standard care surgical approaches.


Eligibility criteria:
inclusion criteria: 1. isolated tibial shaft fractures indicated for intramedullary nailing, 2. acute tibia fractures, 3. closed or open tibia fractures, 4. skeletally mature patient between the ages of 21 and 50, 5. no prior history of knee surgery, 6. no prior history of knee pain, 7. no history of degenerative joint disease or inflammatory arthropathy 8. not pregnant or known to be under the jurisdiction of the department of corrections 9. able to provide informed consent. 10. qualifies for standard care tibial im nailing using either a suprapatellar or infrapatellar approach with no physician preference or definitive clinical indication for one or the other approach 11. ability to communicate, read, and write in english 12. intent of subject to receive follow up fracture care at the pi's institution. exclusion criteria: 1. tibial fractures requiring articular reconstruction (tibial plateau fractures and pilon fractures), 2. periprosthetic fractures, 3. nonunions or malunions, 4. history of previous knee surgery, 5. history of preexisting knee pain, 6. history of degenerative arthritis or inflammatory arthropathy, any evidence of degenerative changes of pre-operative knee radiographs, and any concomitant injury to that limb. 7. any contraindication to mri imaging 8. retained stainless steel hardware proximal to the knee joint including, but not limited to prior knee replacement. 9. under age 18 at the time of presentation, pregnant or planning to become pregnant within the study period, or under the jurisdiction of the department of corrections. 10. inability to provide informed consent 11. participation in any other medical device or medicinal product study within the previous month that could influence the results of the present study 12. insurance or other circumstantial restriction that would prohibit or interfere with the subject's ability to receive follow up care at the pi's institution. 13. any condition, acute or chronic, that in the opinion of the attending physician or the principal investigator, would contraindicate participation in this study.
low-flow vs. high-flow nasal cannula for hypoxemic immunocompromised patients during diagnostic bronchoscopy

Conditions: Immunocompromised; Hematologic Malignancy; Post Hematopoietic Stem Cell Transplant; Hypoxia; Pulmonary Infiltrates

Summary: pneumonia is a lung infection. fiberoptic bronchoscopy is a test to diagnose the type of lung infection. while this procedure is being performed, a small amount of oxygen is delivered into the nose (low flow nasal cannula). occasionally during this procedure, the blood oxygen of the patient may drop and an intervention such as increasing the oxygen flow, or placing the patient on a breathing machine is required. an alternative device called 'optiflow' can provide high flow oxygen through nasal cannula, and is comfortable for patients. if optiflow is used during bronchoscopy, it may prevent the blood oxygen from dropping.

pneumonia is a lung infection that is a common complication in people with cancer, because of a weak immune system. fiberoptic bronchoscopy is a test that is commonly used to help doctors diagnose the type of lung infection and treat it appropriately. it involves passing a thin tube with a camera at the end inside the lungs, and taking some fluid samples which are sent for analysis. while this procedure is being performed, a small amount of oxygen is delivered into the nose (low flow nasal cannula). occasionally during this procedure, the blood oxygen of the patient may drop (even if the patient is receiving oxygen, and especially if the patient has severe pneumonia), and the procedure may have to be interrupted or prematurely stopped. if the oxygen level drops significantly, an intervention such as increasing the oxygen flow, or in the worst-case scenario temporarily placing the patient on a breathing machine is required. an alternative device called 'optiflow' can provide high flow oxygen through nasal cannula, and is comfortable for patients. optiflow was approved by health canada in 2006, and is commonly used in hospitals in ontario and around the world to support patients whose blood oxygen is low. if optiflow is used during bronchoscopy, it may prevent the blood oxygen from dropping.

Eligibility criteria:
inclusion criteria: * adult patients ≥18 years scheduled to undergo fob (as determined by their medical care team) who are immunocompromised (active hematologic malignancy or post hematopoietic stem cell transplant), and are hypoxic with pulmonary infiltrates. hypoxia will be defined as requiring supplemental low flow oxygen ≥ 2l/min by nasal cannula to maintain spo2 \>90%. exclusion criteria: 1. requiring supplemental oxygen \> 8l/min by nasal cannula; 2. receiving hfnc before randomization; 3. nasal deformity or packing precluding hfnc use; 4. hypercapnia (paco2 \> 60) or respiratory acidosis (ph \<7.25); 5. requiring niv for over 1 hour or intubated.

Keywords: hfnc bronchoscopy hypoxia immunocompromised hematological malignancy
safety and immunogenicity of a inactivated influenza vaccine when administered to non elderly adults and elderly subjects.

Conditions: Influenza Disease

Summary: the purpose of this study is to evaluate safety and immunogenicity of a single intramuscular (im) injection of a surface antigen, inactivated, influenza vaccine, formulation 2005-2006, when administered to non-elderly adults and elderly subjects


Eligibility criteria:
inclusion criteria: * subjects 18 years of age or older exclusion criteria: * any serious disease such as: cancer, autoimmune disease, advanced arteriosclerotic disease or complicated diabetes mellitus, chronic obstructive pulmonary disease (copd) that requires oxygen therapy, acute or progressive hepatic disease, acute or progressive renal disease, congestive heart failure * hypersensitivity to eggs, chicken protein, chicken feathers, influenza viral protein, neomycin or polymyxin or any other component of the vaccine * history of neurological symptoms or signs, or anaphylactic shock following administration of any vaccine * known or suspected (or high risk of developing) impairment/alteration of immune function

Keywords: influenza non elderly adult and elderly vaccine
follow-up study of l059 (levetiracetam) in epileptic patients with partial onset seizures by open label method

Conditions: Epilepsy, Partial

Summary: the safety and efficacy of l059 was evaluated in patients who completed "n165 clinical trial of l059". they received l059 at a daily dose from 1,000 mg to 3,000 mg in addition to their standard concomitant aeds


Eligibility criteria:
inclusion criteria: * patients who completed the evaluation period (week 16) of n165 clinical trial of l059 * patients/the parent or guardian wish to continue treatment with l059 and to enter n165 follow-up study, and also the investigator admit the necessity of the repeated intake of the investigational drug for the patients. exclusion criteria: * patients who had not participate in n165 clinical trial of l059. * patients who had participated in n165 clinical trial of l059 with no intention of entering the follow-up study taking the same medication. * patients had not been in compliance with requirements of protocol for n165 clinical trial of l059 in the course of the study.

Keywords: epilepsy, partial keppra levetiracetam
a real-world study of cardiac ablation for psvt using st catheter

Conditions: AVRT, AVNRT

Summary: paroxysmal supraventricular tachycardia known as psvt includes atrioventricular reentrant tachycardia (avrt) and atrioventricular nodal reentrant tachycardia (avnrt). this study is multicenter, retrospective, cohort study. this study will collect real world data of avnrt and avrt cohorts retrospectively to evaluate the effectiveness and safety in real world clinical practice. 300 subjects with psvt will be consecutively enrolled backwards since 02 nov 2017, and at least 100 subjects for each cohort. cohort one: avnrt cohort two: avrt, including wolff-parkinson-white syndrome（wpw）


Eligibility criteria:
inclusion criteria: 1. waiver of informed consent is approved by ethics committee, or follow methods approved by ethics committee to get patient's informed consent (such as get informed consent by telephone contact, etc.). 2. patients diagnosed as atrioventricular reentrant tachycardia (avrt), atrioventricular node reentrant tachycardia (avnrt) after surgery/discharge, and the existing source records must include 1) at least 1 copy of preoperative ecg or intraoperative electrophysiological examination results;2) information about the acute procedure outcome. 3. patients were ablated by st catheter. 4. adult patients 18 years or older. exclusion criteria: 1. contraindications for the use of st catheters, including: 1. ventriculotomy or atriotomy was performed within 8 weeks before the procedure; 2. presence of myxoma or intracardiac thrombus; 3. fitted with artificial valves; 4. active systemic infection; 5. atrial septal patch. 2. pregnant women

Keywords: avrt, avnrt
a phase iii study comparing total and partial omentectomy for patients with advanced gastric cancer

Conditions: Gastric Cancer

Summary: this is a phase iii, multicenter, prospective, randomized, controlled clinical trial to evaluate the impact of omentectomy for advanced gastric cancer on patient survival.

in order to evaluate the impact of omentectomy for advanced gastric cancer on patient survival, we designed this trial. patients who received curative gastrectomy were divided into two groups based on whether they underwent omentectomy. the purpose of this study is to prove the non-inferiority of omentum preservation compared with omentectomy in patients with t3-t4a gastric cancer.

Eligibility criteria:
inclusion criteria: 1. had been treated with radical resection (d2, r0) of gastric cancer (lymph node≥16); 2. physical condition and organ function allows to tolerable abdominal surgery; 3. willing and able to comply with the program during the study period; 4. written informed consent provided; 5. ≥ 18 and ≤ 70 years of age; preoperative gastric cancer patients with pathologically confirmed; 6. with more than a 6-month life expectancy; 7. no other serious concomitant diseases; sufficient organ functions; 8. no previous history of chemotherapy or radiotherapy; 9. all patients accept 8 cycles xelox chemotherapy regimen; 10. clinical stage: t3-4an0-+m0; 11 . macroscopic types :borrmann i-iii; 12. not greater curvature tumor; with distal or total gastrectomy； 13. no previous surgery for any abdominal disease, except an appendectomy for appendicitis, a laparoscopic cholecystectomy for gallbladder stones; no previous history of peritonitis, pancreatitis; 14. karnofsky performance status (kps)\>60; eastern cooperative oncology group performance status (ecog): 0-1. exclusion criteria: pregnancy or breast feeding; 2. patients with serious liver disease (such as cirrhosis, etc.), kidney disease, respiratory disease or uncontrolled diabetes, hypertension and other chronic systemic diseases, heart disease with clinical symptoms, such as congestive heart failure, coronary heart disease symptoms, drug is difficult to control arrhythmia, hypertension, or six months had a myocardial infarction attack, or cardiac insufficiency; 3. organ transplantation patients need immunosuppressive therapy; 4. severe recurrent infections were not controlled or with other serious concomitant diseases; 5. patients got other primary malignant tumors (except curable skin basal cell carcinoma and cervical cancer in situ) except gastric cancer within 5 years; 6. psychiatric disease which require treatment; 7. have the history of organ transplantation; 8. within 6 months before study starts and in the process of this study, patients participate in other clinical researches. 9. advanced gastric cancer with omentum invasion 10. patients can't treated with xelox after surgery; 11 . macroscopic types : borrmann iv; 12. tumor invasion of adjacent organ (t4b) or with distant metastasis#m1 #; 13. tumor invasion the greater curvature invasion.

Keywords: gastric cancer prognosis omentectomy