Kornimate/medical-research-clean huggingface dataset:
aerobic capacity and physical fitness level of adolescents with pcos

Conditions: Polycystic Ovary Syndrome

Summary: polycystic ovary syndrome (pcos) is associated with hyperandrogenism, hyperinsulinemia and insulin resistance starting in the perimenarchal period. insulin resistance also increases the risk of developing glucose intolerance, type 2 diabetes, hypertension, dyslipidemia and cardiovascular disorders. studies on adult women with pcos show that their aerobic capacity is affected. therefore, in this study; it was aimed to compare the physical and cardiovascular fitness levels of adolescent pcos patients with healthy adolescents.

polycystic ovary syndrome (pcos) is associated with hyperandrogenism, hyperinsulinemia and insulin resistance starting in the perimenarchal period. insulin resistance also increases the risk of developing glucose intolerance, type 2 diabetes, hypertension, dyslipidemia and cardiovascular disorders. studies on adult women with pcos show that their aerobic capacity is affected. therefore, in this study; it was aimed to compare the physical and cardiovascular fitness levels of adolescent pcos patients with healthy adolescents.total fat and muscle ratios will be measured with the bioelectrical impedance test (bia) instrument for body composition evaluation of individuals in both groups. body mass index (bmi), waist/hip and waist/height ratios will be recorded. the level of cardiovascular fitness will be evaluated with the pacer test, which is among the fitness gram test protocol. for physical fitness level, muscular strength parameter will be evaluated with hand dynamometer and knee extensor muscle strength, and muscular endurance parameter will be evaluated with sit-up and push-up tests. participants' physical activities will be evaluated with the adolescent physical activity questionnaire (paq-a).the quality of life of individuals with pcos will be evaluated with the polycystic ovary syndrome quality of life-50 scale.

Eligibility criteria:
inclusion criteria of patients : * being between the ages of 14-24, * collecting polycystic syndrome according to rotherdam, * not having had covid-19. exclusion criteria of the patients : * not to be between the ages of 14-24, * not showing the symptoms of polycystic ovary syndrome (pcos), * having had covid-19, * having a chronic disease diagnosed other than pcos, * having cognitive impairment that will affect their cooperation with tests. healthy group inclusion criteria * being a female adolescent between the ages of 14-24, * not having been diagnosed with any chronic disease, * adolescents with regular menstrual cycles, * not taking any medication known to affect hormone, lipid and carbohydrate metabolism, * not having clinical signs of hyperandrogenism, * not having had covid-19. healthy group exclusion criteria * not to be between the ages of 14-24, * having a chronic disease, * having had covid-19, * having cognitive impairment that will affect their cooperation with tests.

Keywords: aerobic capacity physical fitness
intervention for postpartum infections following caesarean section

Conditions: Surgical Wound Infection; Infection; Cesarean Section; Cesarean Section; Dehiscence; Complications; Cesarean Section; Complications; Cesarean Section, Wound, Dehiscence; Wound; Rupture, Surgery, Cesarean Section

Summary: the purpose of this study is to examine whether negative pressure wound therapy is an effective wound treatment compared to conventional wound treatment in the period of time from reoperation to re-suturing in women having surgical wound rupture after caesarean section.

this study is a non-blinded randomized controlled trial and a concurrent health economic. the study examines the effect on wound healing using npwt compared with conventional wound treatment in women, who experience spontaneous dehiscence or where a surgeon deliberately opens the wound after caesarean section (cs). women, who have given informed consent, will be randomized to either intervention or control group via a computer-generated randomization program. it is not possible to blind either participants or therapists. the analysis will be carried out on an intention to treat basis. women with post-cs wound infection will be hospitalized and the wound will be reopened and cleaned under general anaesthesia. in the intervention group women will be treated with npwt. the change of wound dressing on the second day takes place in the obstetrical or plastic surgery ward. on the fourth day, the npwt material will be removed and the wound evaluated before re-suturing. in the control group the wound will be treated with a hydrofiber or alginate dressing. changes of wound dressing will take place on the second and fourth days as in the intervention group. in both groups, when the wound is evaluated on the second and fourth day, it will be described and measured (depth, width, length). after four days of treatment, the wound will be re-sutured in both groups. it is expected that some wounds are not suitable for re-suturing on the fourth day. if a woman does not want to participate, she will receive the conventional treatment, which corresponds to the treatment in the control group. women, who do not wish to participate, will be asked for permission to use their data in the analysis.

Eligibility criteria:
inclusion criteria: * age ≥ 18 year * women, who can read and understand danish exclusion criteria: * serious illness requiring medical treatment, such as cancer * stillborn child * if the fascia is ruptured

Keywords: randomized controlled trial economical evaluation caesarean section cesarean section postoperative wound treatment surgical site infections wound infections infectious morbidity negative pressure wound therapy
cold argon plasma (cap) application in the wound treatment after open hemorrhoidectomy

Conditions: Cold Argon Plasma

Summary: this is single-center, prospective, randomized study

this study will include patients with 3-4 stage hemorrhoids. they will undergo an operation of open hemorrhoidectomy. patients will be divided into a study group and a control group. study group patients during a post-operation period except a standard treatment (antiseptic solutions and antibacterial and wound healing ointments) of a post-operation wound will be treated with cold argon plasma. control group patients will be treated with a standard treatment. wound healing speed will be researched.

Eligibility criteria:
inclusion criteria: * 3-4 stage hemorrhoids * 3 hemorrhoids exclusion criteria: * patients underwent anal canals intervention * acute hemorrhoids * inflammatory bowel disease * co-morbidity diseases of anal canal and perianal area * concurrent conditions in the stage of decompensation

Keywords: cold argon plasma hemorrhoidectomy wound healing hemorrhoids
listening benefits from a hearing-aid app, a personal sound amplification product, and a hearing aid in hearing-impaired listeners

Conditions: Hearing Disorders

Summary: interest and demand for sound amplifiers are increasing due to the burden of purchasing hearing aids and technological advances in healthcare products, and the demand is expected to increase rapidly. for sensorineural hearing loss patients, who are subject to wearing hearing aids, it aims to compare the effect of hearing aid application and personal sound amplification product (psaps) compared to the hearing aids


Eligibility criteria:
inclusion criteria: 1. adults over the age of 20 who speak korean as their mother tongue and have no mental or physical limitations in conducting test. 2. hearing loss patients with a hearing threshold of 26 db or higher in the four frequency (0.5, 1, 2, 4 khz) 3. those who do not have a history of neurological disease, cognitive disorder, learning disorder, or language disorder at the time of recruitment exclusion criteria: 1. in case that communication is difficult, equipment cannot be handled, or it is difficult to cooperate with the inspection 2. acoustic nerve lesions or central nervous system disease 3. those suspected of having false hearing loss 4. those who have secondary benefits related to clinical trials

Keywords: hearing aid, personal sound amplification product, hearing aid application, hearing loss
extension to a study on the efficacy and safety of vildagliptin in combination with insulin in patients with type 2 diabetes

Conditions: Diabetes Mellitus, Type 2

Summary: many people with type 2 diabetes cannot maintain their target blood glucose levels on a single therapy. this is a 28-week extension to a study to assess the safety and effectiveness of vildagliptin, an unapproved drug, in lowering overall blood glucose levels when added to insulin in people with type 2 diabetes who are not at target blood glucose levels on insulin alone. the purpose of the extension study is to gather data on the long-term safety and effectiveness of vildagliptin in people with type 2 diabetes.


Eligibility criteria:
inclusion criteria: * only patients successfully completing study claf237a2311 are eligible * written informed consent * ability to comply with all study requirements exclusion criteria: * premature discontinuation from claf237a2311 * other protocol-defined exclusion criteria may apply

Keywords: type 2 diabetes vildagliptin
brain and cognitive changes after reasoning training in individuals with mild cognitive impairment

Conditions: Mild Cognitive Impairment

Summary: individuals aged 55 and older may experience negative effects of cognitive decline. the proposed research seeks to evaluate the benefits of different types of interventions: reasoning training following transcranial direct current stimulation (tdcs) and reasoning training following sham transcranial direct current stimulation (tdcs) on frontal- lobe mediated cognitive measures of executive control in adults with memory complaints, in the absence of dementia.

the purpose of this study is to evaluate the impact of reasoning training on individuals with complaints of changes in memory or thinking in the absence of dementia, when combined with transcranial current stimulation (tdcs). the reasoning training being studied is a strategy based program where individuals are taught strategies designed to engage the frontal lobes. participants will randomly be placed into one of two groups (1) reasoning training following transcranial current stimulation (tdcs) as compared to (2) reasoning training following sham tdcs. the study will be done with adults between the ages of 50 and 80 with consistent memory complaints or lower baseline performance on memory measures. the primary hypothesis is that individuals receiving tdcs prior to brain training will have a stronger response to brain training than those in the sham tdcs group. response to training will be measured by improved cognitive function and neural changes as measured by neuropsychological testing, mri, and eeg. mri will be used to evaluate the impact of reasoning training on brain blood flow, structure and function, and to measure changes in brain energy metabolism and electroencephalogram (eeg) to evaluate intervention outcomes. the reasoning training program will be conducted in small groups at the center for brainhealth.

Eligibility criteria:
inclusion criteria: * safely have an mri * cognitive complaints in the absence of dementia * participate in tasks involving motor abilities such as use of at least one arm and hand * read, speak, and comprehend english * 50-80 years of age * comprehend simple instructions, perform tasks, and take part in intervention exclusion criteria: * not proficient in reading, comprehending, or speaking english * individuals who have any significant health, neurological, or psychiatric illness, or history of substance abuse * individuals with any mr contraindications (i.e., non-removable metal within/on the body) * individuals taking medications which are contraindicatory for the tdcs procedure * individuals who are left-handed * not proficient in reading,comprehending, and speaking english * females who are not post-menopausal * pre-existing cerebral palsy, autism, epilepsy, schizophrenia, pervasive developmental disorder, thyroid diseases, diabetes, claustrophobia, non-correctable vision problems, major depression, psychosis, active behavioral disorder, or uncontrolled epilepsy. * women who are pregnant
virtual reality-based relaxation and exergaming vs. traditional relaxation for primer dysmenorrhea

Conditions: Primary Dysmenorrhea

Summary: the goal of this clinical trial is to investigate the acute effects of virtual reality-based relaxation (immersive vr relaxation) and exergaming (non-immersive vr) compared to traditional jacobson's relaxation on symptoms of primary dysmenorrhea (pd) in women aged 18-30 years with regular menstrual cycles. the main questions it aims to answer are: does immersive vr relaxation reduce abdomino-pelvic pain and menstrual symptom severity more effectively than jacobson's relaxation? does non-immersive vr exergaming provide better pain relief and symptom management compared to traditional relaxation methods? hypotheses: immersive vr relaxation will result in significantly greater reductions in abdomino-pelvic pain and menstrual symptom severity compared to traditional relaxation. non-immersive vr exergaming will also provide better outcomes in pain and symptom management compared to traditional relaxation. researchers will compare immersive vr relaxation, non-immersive vr exergaming, and jacobson's relaxation (control group) to determine the relative effectiveness of each intervention. participants will: engage in a 20-minute session of one of the assigned interventions. complete questionnaires on abdomino-pelvic pain, menstrual symptoms, and perceived effectiveness. participate in follow-up assessments for sleep quality during menstruation. this study aims to explore innovative, technology-driven approaches for managing menstrual symptoms and their effectiveness relative to traditional methods.

this study seeks to address this gap by investigating whether these innovative approaches can provide superior symptom relief. by evaluating pain intensity, symptom severity, and perceived effectiveness, this research will provide valuable insights into the feasibility and advantages of integrating technology into dysmenorrhea management.

Eligibility criteria:
inclusion criteria: * women aged 18-30 with no pregnancy history. * a regular menstrual cycle (28 ± 7 days) over the past 6 months * menstrual pain with a visual analog scale score \>4 during this period exclusion criteria: * regular medication use or medical treatment during the study (e.g., oral contraceptives, antidepressants). * recent musculoskeletal trauma or surgery. * intrauterine device use or pathological conditions/ultrasound findings of secondary dysmenorrhea * consumption of painkillers, alcohol, recreational drugs, or similar substances within the last 48 hours.

Keywords: exercise therapy pain management primary dysmenorrhea progressive muscle relaxation virtual reality
the effect of fenoldopam in solitary partial nephrectomy surgery

Conditions: Partial Nephrectomy

Summary: this trial will study the effects of fenoldopam on renal function in patients who have a single kidney undergoing surgery to remove part of that kidney secondary to renal cell carcinoma. the investigators will monitor and evaluate throughout the perioperative course the kidney function. normally kidney function is predicted to show a worsening followed by an improvement after surgery. the investigators want to specifically identify if the use of fenoldopam lessens the injury to the kidney with this surgery.

prospective, randomized, blinded study-dividing patients into one of two groups: fenoldopam or placebo. the infusion will commence after placing the patient in a lateral/flex position during the operation. the infusion will continue for a total of 24 hours.study time period will be approximately six weeks from the date of surgery. specifically, the following pre- and post operative laboratory results will be recorded if available: . basic metabolic panel - pre-op, post op days 1, 2, 3, 4, and 6 weeks * serum osmolality, urine osmolality, urine sodium - pre-op, post op days 1, 3 * glomerular filtration rate - pre-op, post op days 1, 3, and 6 weeks

Eligibility criteria:
inclusion criteria: * patients who have a solitary kidney and present for a partial nephrectomy * patients who have one atrophic minimally functioning kidney and present for partial nephrectomy on the other kidney exclusion criteria: * history of current renal disease beyond the diagnosis of renal malignancy * insulin dependent diabetes mellitus, myocardial infarction without subsequent coronary artery bypass or angioplasty * history of congestive heart failure, renovascular occlusion greater than 45 minutes or less than 15 minutes, greater than one half of the solitary kidney resected * a major perioperative complication that would potentially affect postoperative renal function (myocardial infarction, congestive heart failure, pulmonary embolus, massive hemorrhage and hypotension, ureteral obstruction or vascular thrombosis), and evidence of nephrotoxicity due to antibiotics

Keywords: nephrectomy fenoldopam atrophic minimally functioning kidney
pharmacological cognitive enhancement

Conditions: Fluid Inteligence; Modafinil; Healthy Young Subjects; Resting State Networks

Summary: there is growing debate on the use of drugs that can promote cognitive enhancement. amphetamine-like drugs have been employed as cognitive enhancers, but all of them have important side effects and may induce addiction. in our study, we will investigate the use of modafinil which, in recent years, has been proposed as cognitive enhancer. modafinil appears to have less side effects compared to amphetamine-like drugs and we will analyzed whether the drug can influence cognitive performances and the brain resting state network activity of healthy young subjects.

subjects will be included in a double-blind, placebo-controlled study in which a single dose (100 mg) of modafinil will be administered. both groups will be, before and three hours after administration of drug or placebo, tested for neuropsychological performances with the raven's advanced progressive matrices ii set (apm). resting state functional magnetic resonance (rs-fmri) will be also employed, before and after three hours, to study changes in the activity of resting state brain networks. finally, with diffusion tensor imaging (dti) we will evaluate the structural connectivity of the two groups.

Eligibility criteria:
inclusion criteria: * subjects do not meet the criteria for exclusion exclusion criteria: * current signs of psychiatric, neurological or medical (hypertension, cardiac disorders, epilepsy) conditions as determined by the millon test and by clinical examination;subjects showing visual or motor impairments. all subjects taking any psychoactive drug or having a history of alcohol abuse.

Keywords: rsfmri, brain plasticity, cognitive enhancer
topical ketamine analgesia in children undergoing tonsillectomy: a clinical and serum level assays study.

Conditions: Postoperative Pain

Summary: the aim of this study is to evaluate the analgesia efficacy of local ketamine given by two different doses in pediatric patients undergoing tonsillectomy operations

in this double-blinded, clinically-controlled trial, 100 child will be randomized into four groups of 25 patients each; control group, intravenous ketamine group received 0.5mg iv. ketamine, and two local ketamine groups receiving local ketamine by nebulization in two different doses; 1 and 2mg/kg. the verbal rating pain scale, time to first postoperative analgesic request, total analgesic consumption during 1st 24 h postoperative, serum ketamine levels, intra operative blood loss, postoperative bleeding, and adverse effects were evaluated.

Eligibility criteria:
inclusion criteria: * asa physical status i-ii patients aged 7-12 years and scheduled for elective tonsillectomy due to recurrent or chronic tonsillitis will be included in the study exclusion criteria: * patients with known hypersensitivity to medication drugs, coagulation disorders, thrombocytopenia, and significant cardiac, renal, pulmonary or hepatic disease.
investigation of serotonin receptor binding in the migraine brain using positron emission tomography

Conditions: Migraine Without Aura

Summary: migraine affects 16% of the world population and is one of the most disabling of all disorders. it is a complex brain disorder characterized primarily by recurrent headache attacks. the signaling molecule serotonin (5-hydroxytryptamine, 5-ht) has for decades been thought to play a central role in migraine pathophysiology. the most effective class of abortive migraine drugs, the triptans, act on 5-ht receptors. however, the migraine-specific actions of serotonin and the mechanisms of triptans are still unknown. in this project the investigators will use high-resolution positron emission tomography and specific radioligands to investigate the significance of serotonin in migraine. two newly developed radioligands that are specific for the 5-ht1b and 5-ht4 receptor, respectively, will be applied. to investigate the level and distribution of serotonin in the migraine brain the investigators will compare the binding of these ligands in episodic migraine patients with healthy controls. in addition, the investigators will include chronic migraine patients to evaluate the relation between the level of serotonin in the brain and the frequency of migraine attacks. to investigate the changes in the serotonin level during a migraine attack and the effects of triptans on the central nervous system the investigators will repeat the scans using the 5-ht1b specific ligand during induced migraine attacks and following treatment with sumatriptan. the results from this study will shed light on the role of serotonin in the migraine brain and elucidate the migraine-specific action of triptans. this will improve our understanding of the migraine pathophysiology and, potentially, facilitate the development of more efficient treatment of migraine.


Eligibility criteria:
inclusion criteria, both groups: • written informed consent inclusion criteria, episodic migraine patients: * migraine without aura according to the international headache society (ihs) 0-4 days per month * the migraine is treatable with sumatriptan inclusion criteria, chronic migraine patients: fulfill ihs criteria for chronic migraine inclusion criteria, healthy controls: * do not suffer from migraine according to ihs * do not have any first degree relatives with migraine exclusion criteria: * tension type headache more than 5 days per month during the last year. * tension type headache on the experimental day. * any other primary headache disorder * migraine 48 hour before and after the experimental day (only episodic migraine patients) * use of antimigraine medication or pain-killer on the experimental day before pet * pregnant or breastfeeding women. * contraindications against mri. * history or clinical sign of cardio- or cerebrovascular disease. * untreated severe mental disorder or drug abuse. * other diseases or disorders interpreted, by the examining doctor, to interfere with participation in the study. * not accepting information about potential accidental findings during the experiment.