Kornimate/medical-research-clean huggingface dataset:
inflammatory markers and adverse outcomes in chronic kidney disease

Conditions: Chronic Kidney Disease

Summary: longitudinal cohort of patients with chronic kidney disease followed in 3 kidney centers in ontario. the goal is to determine whether and how rates of renal disease progression are affected by inflammatory markers, fgf23 levels, and genetic polymorphisms

this longitudinal cohort study will follow 2500 prevalent chronic kidney disease (ckd)patients under the care of a nephrologist at 3 southern ontario nephrology centres and all affiliated satellite centres with an estimated glomerular filtration rate (egfr) less than 60 ml/min to determine the rate of their renal disease progression over a 36 months. all ckd patients older than 18 years of age may be included in this study. this study will analyze, with 6 month serial measurements, conventional biochemical, hormonal and metabolic parameters in addition to the demographics, clinical status, medications and blood and urine samples of these patients. this study will assess the influence of inflammation on fgf23 and genetic polymorphisms that may reflect the processes involved with disease progression.

Eligibility criteria:
inclusion criteria: * patients referred to a nephrologist for evaluation of ckd or those currently seen by a nephrologist, with egfr less than 60 ml/min * patients that are erythropoietin treatment naive * transplant patients with failing grafts requiring nephrologists follow-up * patients currently not receiving rrt consenting to be in the study * adults 18 years of age and older exclusion criteria: * functioning organ transplant * life expectancy less than 12 months * patients currently receiving rrt or who will likely initiate rrt within 6 months * patients unable or contraindicated to receive eprex® as erythropoietin replacement therapy for the correction of anemia related to ckd

Keywords: ckd progression inflammation fgf23 genetic biomarkers
tele-rehabilitation study for people with a history of stroke

Conditions: Stroke

Summary: stroke results in long-term disability for many people, and particularly for survivors of stroke who have cognitive impairments. however, a decreasing proportion of stroke patients are able to access or receive publicly funded rehabilitation. the investigators have shown in previous studies that in-person delivery of the cognitive orientation to daily occupational performance (co-op) rehabilitation approach to promoting attainment of everyday life goals has resulted in improvements in functional independence and executive function. in a small pilot study of tele-co-op with people with chronic traumatic brain injury (tbi) (n=3), the investigators found the delivery method was feasible and that participants were satisfied with the treatment and demonstrated clinically significant improvements on personally meaningful activities. the investigators will investigate the feasibility, preliminary efficacy, and cost-effectiveness of delivering co-op in an online format to reduce disability post-stroke. the study design is a single-blind (assessor), randomized wait-list control trial with a one-month retention follow-up. all therapy and testing sessions will be delivered online. we hypothesize that participants will demonstrate improvement in everyday activities and community participation.


Eligibility criteria:
inclusion criteria: * community-dwelling adults at least three months post-stroke * fluent in written and spoken english * impairment of executive cognitive functions * ability to self-identify specific areas of difficulty in their everyday life that they would like to improve * access to a computer or tablet with a high-speed internet connection exclusion criteria: * presence of dementia * severe concurrent depression * severe aphasia * concurrent substance abuse
the impact of positioning on bottle-feeding in preterm infants. a comparative study pmmhhri-2018/v/9-szb

Conditions: Bottle Feeding; Premature

Summary: one of the challenges of modern neonatology is to identify the right and effective method that can improve oral feeding. optimal feeding position may contribute to improving the quality and safety of bottle-feeding in premature infants.

purpose: the aim of the study was to compare the advantages of semi-elevated (sep) with side-lying positioning (slp) during bottle-feeding of preterm infants. method: the study included forty two neonates (n=42) born ≤34 weeks of gestational age. four bottle-feeding sessions were tested in each of the newborns: two in the sep and two in the slp. the position for the first study was randomly assigned, then positioning changed after each feeding session. in one day, only two consecutive feeding sessions which were included to the study in order to minimize fatigability as a disrupting factor. the levels of saturation (spo2) and heart rate (hr) were measured as the parameters indicative of the newborn's physiological stability. the factors determining the qualitative aspect of feeding included the total time of declines of spo2 ≤85%, level of the newborn's alertness according to the neonatal behavioral assessment scale (nbas), and the occurrence of choking episodes. the proportion of milk consumed (volume of milk eaten relative to the expected volume) and the duration of the feeding and feeding session were also recorded.

Eligibility criteria:
inclusion criteria: * circulatory and respiratory stability; * readiness for oral feeding according to each child's speech-language pathologist assessment; * prematurely born infants who were in the process of being transferred from enteral nutrition (or enteral nutrition + parenteral nutrition) to full oral feeding and were fed orally at least 4- 6 times within twenty-four hours; * parents gave informed consent to participate their infant in the study. exclusion criteria: * disorders which could significantly affect the feeding course, such as cleft lip and/or palate, facial paralysis and/or congenital defects of the facial skeleton; * the presence of detected congenital abnormalities and metabolic diseases; low apgar score (less than 5 points at the 5th and 10th minute of the measurement); * administered analgesics, anticonvulsants and sedatives; * \<72 hours from extubation prior the trial; * parents refusal to participate in the study or when bottle-feeding was not the parental preference.

Keywords: premature infant bottle feeding side-lying position semi-elevated position oral feeding
morphine consumption in thoracotomy

Conditions: Postoperative Pain

Summary: importance of effective postoperative pain management is well known. the undesired effects of pain can be prevented with multimodal analgesia for the patient. thoracotomy operations are associated with high levels of pain. with the use of ultrasound, many regional anesthesia techniques were described to provide effective postoperative analgesia. the aim of this study was to compare the postoperative effect of paravertebral block (pvb) and erector spinal plane block (espb) in thoracotomies.


Eligibility criteria:
inclusion criteria: * asa i-iii patients undergo elective thoracotomy surgeries. exclusion criteria: * obesity (bmi \> 35 kg/m2) * infection of the skin at the site of the needle puncture area * patients with known allergies to any of the study drugs * coagulopathy

Keywords: postoperative pain thoracotomy paravertebral block erector spina plane block
effect of mediterranean diet on non-alcoholic fatty liver disease

Conditions: NAFLD

Summary: non-alcoholic fatty liver disease (nafld) is a clinical/biochemical condition associated with the metabolic syndrome. as the disease stems from excess calorie intake and lack of physical activity, the correction of unhealthy lifestyles is the background of any prevention and treatment strategy

the majority of nafld patients are characterized by high body mass index, insulin resistance and they show a remarkably higher energy intake in comparison to individuals without hepatic steatosis. several authors have proposed dietary weight loss strategies to ameliorate or reverse fatty liver because of the potential role of weight loss on the supposed risk factors of liver injury, mainly insulin resistance, free fatty acid levels, and pro-inflammatory and profibrotic adipokines. there are no definite data regarding how much and how rapidly weight loss should be to have the more favorable effects, but in obese children, the larger the weight loss, the larger the decrease of liver enzyme levels and the lower the prevalence of nafld. the american gastroenterological association recommends a weight loss target of 10% of baseline. a loss of at least 10% of body weight in obese patients is associated with a normalization of previously abnormal liver function tests as well as decreased hepatomegaly, but even a moderate weight loss (approximately 6% of baseline weight) can improve insulin resistance and intrahepatic liver content.

Eligibility criteria:
inclusion criteria: * subject enrolled in the cohort nutriep assembled in 2005-2007 * moderate or severe nafld exclusion criteria: * middle nafld * not enrolled in the nutriep cohort * pregnancy

Keywords: nafld clinical trial mediterranean diet low glycemic index
phase 2b efficacy/safety of ornithine phenylacetate in hospitalized cirrhotic patients with hepatic encephalopathy (stop-he)

Conditions: Acute Episode of Overt Hepatic Encephalopathy; Hepatic Encephalopathy

Summary: the purpose of this study is to determine whether ornithine phenylacetate can speed recovery from an acute hepatic encephalopathy episode requiring hospitalization in cirrhotic patients.

the primary objectives of the study were to evaluate the efficacy of ocr-002 for treatment of an acute hepatic encephalopathy (he) episode in cirrhotic patients requiring hospitalization and the safety and tolerability of ocr-002 in hospitalized cirrhotic patients with an acute episode of he.

Eligibility criteria:
inclusion criteria: * hospitalized with an acute episode of hepatic encephalopathy as complication of cirrhosis * elevated venous ammonia exclusion criteria: * renal failure with serum creatinine \> 3 mg/dl or need for dialysis * molecular adsorbent recirculation system utilized * pregnancy or breastfeeding

Keywords: hepatic encephalopathy hyperammonemia cirrhosis ornithine phenylacetate ocr-002
study on energy cost prediction of cycle ergometer

Conditions: Healthy; Obesity

Summary: this study purpose is (1) to develop the new energy expenditure equation; (2) to increase accuracy of energy cost prediction of cycle ergometer; (3) to find out some dependent factors.

oxygen consumption (ml/min) was measured while subjects were at rest and exercised at four submaximal workloads in steady state on cycle ergometer. bioelectrical impedance analysis was used to estimate the body fats and skeletal muscle mass.

Eligibility criteria:
inclusion criteria: * healthy female * never received bicycle training exclusion criteria: * exercise testing contraindications

Keywords: healthy female
echocardiographic assessment and clinical implication of functional tricuspid regurgitation in heart failure with reduced or preserved ejection fraction

Conditions: Functional Tricuspid Regurgitation

Summary: purpose functional tricuspid regurgitation (ftr) has been shown to be associated with increased morbidity and mortality in several clinical conditions, including heart failure (hf) with reduced left ventricular ejection fraction as well as pulmonary arterial hypertension (pah). we have designed a study aiming at: characterizing the echocardiographic morphology of the tricuspid valve apparatus and the pathophysiology of ftr in heart failure with reduced, mid-range or preserved left ventricular ejection fraction (hfref, hfmref, hfpef) and in pah patients; correlating the morphologic characteristics of tricuspid valve apparatus with hemodynamic severity of ftr; correlating the severity of ftr with the clinical condition and outcome. methods the study will be a non-interventional, prospective, international, multicenter, longitudinal study. the minimum number of patients which are expected to be enrolled is 300 hf patients, including hfref, hfmref and hfpef patients, whereas 100 pah patients will serve as control. the patients will be enrolled in 20 centers in europe, north america and saudi arabia. the echocardiographic parameters will be analyzed by the local investigators; a quality control committee will evaluate all data entered in the database to identify potential outliers and a random sample of 10% of cases will be blindly re-analysed in a central core-lab. conclusions this study has been designed to improve our understanding of pathophysiological mechanisms and clinical relevance of ftr across all hf phenotypes. the results could potentially allow a more appropriate selection of heart failure patients with ftr for tricuspid valve intervention by percutaneous or surgical repair or replacement.


Eligibility criteria:
inclusion criteria: * consecutive consenting outpatients with hfref, hfmrhf, hfpef or pah, * ambulatory visit routinely planned with an echocardiographic examination, * at the time of the visit at least moderate ftr diagnosed at echocardiography (by visual assessment), * aged ≥ 18 years old, * capable to sign an informed consent. exclusion criteria: * age \< 18 years old, * congenital heart disease, * heart failure due to organic mitral or aortic valve disease. no examination will be performed in addition to what is routinely planned for patients' evaluation.

Keywords: tricuspid regurgitation; heart failure
effect of erythromycin before endoscopy of patients with subtotal gastrectomy (stg), high risk of gastric stasis

Conditions: Subtotal Gastrectomy; Stomach Cancer

Summary: erythromycin has a prokinetic effect through motilin receptor. it evokes migrating motor complex with longer and stronger contraction. in patients with upper gastrointestinal bleeding, it has been shown that erythromycin could clear the stomach of blood, so visual examination could be improved. frequent food stasis is encounted when we examine patients with subtotal gastrectomy. it is postulated that erythromycin reduce food stasis and help to improve endoscopy in these cases.


Eligibility criteria:
inclusion criteria: * patients who undergone stg (billroth i, billroth ii, r-y stg) within 5 years to treat gastric cancer * stage of t1-2n0m0 exclusion criteria: * concomitant therapy with astemizole, cisapride, dihydroergotamine, ergotamine, pimozide, or terfenadine, narcotics, alpha-2-adrenergic agonist, tca, ccb, dopamine agonist, muscarinic cholinergic antagonists, octreotide, exenatide and glp-1 agonist, phenothiazines * chemotherapy hx. * hypersensitivity to erythromycin or any component of the product * pregnancy or lactation * comobidity : dm, aids, neurologic disease(parkinsonism, multiple sclerosis, brainstem stroke or tumor, diabetic or amyloid neuropathy, or primary dysautonomias) scleroderma and other connective tissue disease, recent viral enteritis history * recurrence
doac adrs retrospective study

Conditions: Drug-Related Side Effects and Adverse Reactions

Summary: this retrospective study's objective is to evaluate if cipherome's algorithm could have predicted the serious adverse drug reactions (adrs) experienced by patients while on direct oral anti-coagulants (doacs).

using the latest next generation sequencing tools, this study will evaluate adverse drug reactions (adrs) (e.g., major bleeding or treatment failure) in study participants while on direct oral anticoagulants (doacs). a web-based program will analyze the data obtain from sequencing, and generate a drug safety score (dss). the dss risk score will be compared with pre-specified serious adrs associated with doac therapy. a secondary analysis will involve discovery of novel variants that arise from our analysis and may potentially affect the outcome of doac treatment.

Eligibility criteria:
inclusion criteria: * any adult patient 18 years and older, who experienced a serious adverse drug reaction while taking a doac and is able to provide informed consent. exclusion criteria: * failure to provide informed consent
intestinal microbiota in patients before and after bariatric surgery and healthy controls

Conditions: Obesity

Summary: studying obesity and metabolic syndrome attention is focused more and more on gut microbiota. in humans and animals, bariatric surgery (mainly gastric bypass surgery) lead to alterations of gut microbiota, which seem to be favourable. in this study the investigators aim to examine the effect of different bariatric procedures on composition of gut microbiota.

the human gastrointestinal tract is home to an extremely numerous and diverse collection of microbes communities, collectively termed the "intestinal microbiota". this amazingly complex and poorly understood group of communities has an enormous impact on humans. indeed, microbiota is considered to play a number of key roles in the maintenance of host health, including aiding digestion of otherwise indigestible dietary compounds, synthesis of vitamins and other beneficial metabolites, immune system regulation and enhanced resistance against colonization by pathogenic microorganisms. conversely, the intestinal microbiota is also a potent source of antigens and potentially harmful compounds. schematically, humans can be considered to exist in a state of natural balance with their microbial inhabitants. a shift in the balance of microbiota composition such that it may become deleterious to host health is termed "dysbiosis". dysbiosis of the gut microbiota has been implicated in numerous disorders, ranging from intestinal such as inflammatory bowel diseases and colorectal cancer to disorders with more systemic effects such as diabetes, obesity, insulin resistance and steatohepatitis. the link between the microbes in the human gut and the development of obesity, cardiovascular disease and metabolic syndromes, such as type 2 diabetes, is becoming clearer but, because of the complexity of the microbial community, the functional connections are less well understood. in humans and animals, bariatric surgery (mainly gastric bypass surgery) lead to alterations of gut microbiota, which seem to be favourable. in this study the investigators aim to examine the effect of different bariatric procedures on composition of gut microbiota.

Eligibility criteria:
inclusion criteria: * 30 healthy controls: bmi 18-30kg/m2 good general health * 40 morbidly obese patients (bmi \>35kg/m2) scheduled for either sleeve gastrectomy or gastric bypass surgery exclusion criteria: * antibiotic therapy within the last 2 months before enrolment * regular intake of proton pump inhibitors (ppi) * previous surgery on the gastrointestinal tract (appendectomy acceptable)
dose exploration study of gsk4532990 in. participants with nash or suspected nash

Conditions: Non-alcoholic Fatty Liver Disease

Summary: the purpose of this study is to understand how the drug gsk4532990 is processed in the body (pharmacokinetics) and how it works in the liver (pharmacodynamics) as well as to ensure it is safe and well-tolerated. the total study duration for each participant will be approximately 24-36 weeks.


Eligibility criteria:
inclusion criteria: * participant must be 18 to 75 years of age. * participant must be capable of giving signed informed consent which includes compliance with the requirements and restrictions listed for the study. * participants who have proven diagnosis of nash or suspected nash based on defined study criteria. * participants must meet predefined stable use requirements of concomitant medications based on study criteria. exclusion criteria: individuals who meet any of the following exclusion criteria will not be eligible to participate in the study: * cirrhosis or current unstable liver or biliary disease. * other causes of liver disease including, but not limited to, alcohol-related liver disease, autoimmune disorders. * known weight loss of ≥5% within 3 months prior to screening. * weight reduction surgery or procedures within 2 years of screening. * any contraindication to undergoing liver biopsy. * any contraindication to undergoing magnetic resonance imaging or fibroscan®.

Keywords: gsk4532990 non-alcoholic steatohepatitis (nash) non-alcoholic fatty liver disease (nafld) suspected nash
psychiatric disorders and electrophysiological markers

Conditions: Schizophrenia

Summary: schizophrenia is considered as the most frequent and the most severe chronic psychotic disorder. its evolutionary modes and its clinical symptomatology remain particularly heterogeneous. moreover, the brain processes involved in schizophrenia are still far from being clearly understood. current empirical studies provide a mean duration comprised between 1 and 3 years without any specific diagnosis or treatment. these diagnosis issues are partly based on difficulties in the early distinction between schizophrenia and bipolar affective disorders (bd). these results emphasize the necessity of new early indices (or endophenotypes). such markers are intended to be more specific than classical clinical manifestations. in other words, they have to be absent among patients with differential diagnosis, such as bd. among other possible early indices, several electrophysiological disturbances have been explored. our study is designed to mainly describe the n400 component among patients with schizophrenia or bd. this component is classically interpreted as indexing the integration the meaning of a linguistic stimulus in its preceding context. our main hypothesis aims to show a specific alteration of n400 component among patients with schizophrenia when compared to participants with bd. the second aim of this study concerns the exploration of four other event related potentials (erps) among patients with schizophrenia or bd: * the p50 component, involved in early sensory gating processes, * the p300 component, thought to reflect attentional resource allocation and working memory updating of stimulus context, * the p600 component, elicited during same paradigms than n400, and reflecting their syntactic congruity. * the cnv (contingent negative variation), reflecting processes of motor anticipation regarding to their potential 'endophenotypes' status, our aim consists in comparing the n400 and three other erps among patients with schizophrenia or bipolar affective disorder. since the schizophrenic specificity of such erps alterations still remains rarely studied, we also propose to describe the possible relations between these erps results and clinical scores observed among patients.


Eligibility criteria:
inclusion criteria: * subject showing no severe or progressive somatic pathology, including neurological pathology (head injury, epilepsy, tumor process or multiple sclerosis causing eeg changes incompatible with the observation of erp characteristics of both psychiatric disorders explored) * subject showing a diagnosis of schizophrenia or a diagnosis of bipolar affective disorders, as defined in the dsm iv-tr, in time of inclusion. * subject showing no disorder related to the use of a substance according to dsm iv-tr during the last 12 months prior to enrollment. * subject not showing another psychiatric disorder according to dsm iv-tr (axis 1 disorders), including schizoaffective disorder or a delusional disorder (not schizophrenic). exclusion criteria: * subject unable to give informed consent