Kornimate/medical-research-clean huggingface dataset:
epidemiological tool to detect angina pectoris in blacks

Conditions: Cardiovascular Diseases; Angina Pectoris; Heart Diseases

Summary: to develop a prototype questionnaire for the detection of angina pectoris in blacks.

background: angina pectoris is often considered a manifestation of coronary artery atherosclerosis that is associated with an increased mortality risk. overall, coronary heart disease is the leading cause of morbidity and mortality in united states blacks. in an attempt to standardize the diagnosis of angina pectoris in epidemiologic studies, rose developed a questionnaire for cardiovascular field surveys which has primarily been used in united states and other white populations. however, in 1988, there were no valid epidemiological tools for the assessment of angina pectoris in blacks. the development of a cardiovascular survey instrument capable of assessing angina pectoris in black populations was identified by the association of black cardiologists as an urgent epidemiologic need. also, such a survey instrument could ultimately enhance knowledge and treatment of cardiovascular disease among blacks. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria
supplementing intracytoplasmic sperm injection handling medium with latrunculin a (icsi-la)

Conditions: Infertility

Summary: vienna consensus has identified 10% damage rate after icsi as a competency value. despite the highest quality embryologists doing icsi, degeneration sometimes occurs due to oocyte factors such as the fragile membrane, etc. latrunculin a serves to facilitate spindle or pronuclear transfer procedures helping to reduce the damage rate with no harm reported. using latrunculin a during icsi could serve to rescue some oocytes from the degeneration allowing for more chances of viable zygotes,


Eligibility criteria:
inclusion criteria: * icsi participants exclusion criteria: -
prevalence and risk factors of pressure ulcers in beni suef governorate of egypt

Conditions: Pressure Ulcer

Summary: the study aims at examining the relation between the prevalence and risk factors of pressure ulcers among hospitalized patients in beni suef governorate of egypt

pressure ulcers are defined as localized damage to the skin as well as underlying soft tissue, usually occuring over a bony prominence or to medical devices. immobility and friction are important risk factors for pressure ulcers, malnutrition and body mass index are associated with pressure injury prevalence, the days in hospital, skin moisture and other neurological factors are significant risk factors for pressure ulcer development. beni-suef is one of the upper egypt governorates located about 120 km south of cairo, according to population estimates from 2019, the majority of residents in the governorate live in rural areas, with an urbanization rate of only 23.2%, due to greater reliance on federal and state payers, low volume and complxity of services provided, rural residents often encounter barriers to healthcare that limit their ability to obtain the care they need

Eligibility criteria:
inclusion criteria: * hospitalized patients will be selected from icu and ccu * both sexes males and females * their age ranges between 25-65 years old * patients who have peripheral arterial disease * their body mass index (class ii and class iii obesity) * diabetic patients more than 5 years old exclusion criteria: * medically unstable patients * un cooperative patients * semi- conscious or unconscious patients according to glascow coma scale
an assessment of the effectiveness (efficacy) of odeston (odeston®) in patients with chronic cholecystitis in real medical practice

Conditions: Chronic Cholecystitis

Summary: post-marketing observational clinical study: assessment of the effectiveness (efficacy) of odeston (odeston®) in patients with chronic cholecystitis in real medical practice


Eligibility criteria:
inclusion criteria: * men and women aged 18 to 65 years; * bmi 18.5 - 40; * verified diagnosis: chronic acalculous cholecystitis; * voluntary desire to provide informed consent to participate in the study exclusion criteria: * presence of stones in the gall bladder and bile ducts; * the presence of jaundice, cholestatic liver diseases, liver cirrhosis with decompensation; * increased alt, ast above the 3 upper limits of normal; * hypersensitivity to the components of the drug odeston; * pregnancy and lactation; * prolonged fasting and total parenteral nutrition; * patients with symptoms of acute abdomen at the time of inclusion in the study; * patients with symptoms of acute neurological pathology at the time of inclusion in the study and/or аcute cerebrovascular accident, a history of convulsive syndrome; * presence of cancer; * acute infectious diseases at the time of inclusion in the study; * fever of any origin (above 37.5 c); * patients with symptoms of heart failure; * patients with symptoms of pulmonary failure; * patients with symptoms of acute or chronic renal failure; * a decompensated form of diabetes; * patients with signs of psychiatric disorders.
controlling hyperglycemia among minority population

Conditions: Diabetes

Summary: the purpose of this study is to compare the efficacy of three approaches in diabetes management: (1) community health worker (chw) education; (2) text messaging; and (3) usual hospital-based care. the goal is to determine the most cost-effective method of diabetes management among an economically-disadvantaged, minority population.

the champ study will test the efficacy of two interventions designed to decrease uncontrolled hyperglycemia (defined as hemoglobin-a1c (a1c) at or above 9%) among adults with diabetes. patients from a safety-net hospital will be randomized into three groups: 1) a control group, 2) an intervention providing diabetes self-care text messages, or 3) an intervention using community health workers to provide diabetes education and linkage to care. secondary objectives include increasing diabetes knowledge, improving diabetes self-management, and increasing use of primary care (i.e., make one visit to the physician in 6 months) among the intervention participants. a cost-effectiveness analysis will determine the most appropriate way to reduce the burden of uncontrolled diabetes.

Eligibility criteria:
inclusion criteria: \*hyperglycemia with a1c ≥9% exclusion criteria: * lives greater than 20 miles driving distance from mount sinai hospital * pregnant women with gestational diabetes * advanced end-organ complications due to diabetes that include: end-stage renal disease, stroke with paresis, congestive heart failure (nyha class iii or iv), or other major end-organ complication of diabetes * receiving treatment for a major psychiatric disorder (i.e. schizophrenia) * unable to understand and give informed consent in either english or spanish * currently or previously participated in a diabetes research study * family member currently enrolled in a diabetes research study * previously received diabetes care related cell phone text messages * unable to receive text messages 3-4 times per week * living in a homeless shelter or temporary housing * plans to travel outside of the united states for more than 3 months in next year

Keywords: a1c≥9% minorities economically disadvantaged
an evaluation of a family counseling intervention ("tuko pamoja") in kenya

Conditions: Mental Health Issue; Family Relations; Family Conflict; Child Mental Disorder; Adolescent - Emotional Problem; Adolescent Problem Behavior; Child Behavior; Child Abuse; Marital Conflict; Domestic Violence; Parent-Child Relations; Parenting

Summary: the purpose of this study is to evaluate a family counseling intervention, entitled "tuko pamoja" (translation "we are together" in kiswahili). the intervention, delivered by lay counselors and through existing community social structures, is expected to improve family functioning and individual mental health among members. the sample includes families with a child or adolescent (ages 8-17) experiencing problems in family functioning.

the purpose of this study is to evaluate a family counseling intervention, entitled "tuko pamoja" (translation "we are together" in kiswahili), using a pilot randomized control trial design. the intervention, delivered by lay counselors and through existing community social structures, focuses on improving family relationships and mental health with content derived from evidence-based practices; these include family systems and solution-focused family therapies and cognitive behavioral strategies. it is components based, with modules delivered based on need. the content and structure has been adapted in both content and implementation model based on formative research in this context. primary hypotheses include achieving improvements in outcomes related to: 1. family functioning, including elements such as communication, emotional closeness, structure and organization, and satisfaction for the overall family; this also includes indicators of functioning at dyadic levels (i.e., parent-child and couples functioning) 2. mental health of both children and caregivers. the investigators also hypothesize feasibility and acceptability, including high fidelity and adequate clinical competency by the non-specialist counselors, based on a previous evaluation of the program. the study will follow a randomized controlled design with a target sample size of 60 families, including up to 2 caregivers per family (who hold primary responsibility for the child whether biological or non-biological) and a target child identified either through caregiver-report of the child about whom they are most concerned or randomly, if there is no child with particular concerns. families will be recruited in two rounds of 30 families due to logistical limitations of enrolling all 60 at the same time.

Eligibility criteria:
inclusion criteria: * family with self-reported elevated distress (e.g., high levels of conflict) that also has a child/adolescent (ages 8-17) with caregiver-reported emotional or behavioral concerns exclusion criteria: * families without reported distress and/or without reported adolescent distress. * families with children older than 17 or younger than 8 years of age. * families in which primary caregivers or children are living too far outside of the community to participate in treatment.
patient narcotic requirements after outpatient otolaryngology procedures

Conditions: Outpatient Surgery; Pain, Postoperative

Summary: patient's pain level and narcotic requirements will be evaluated after routine outpatient otolaryngology procedures. this will be done by having study participants record their pain level and medication usage from home.

it is routine practice to give narcotic medication after surgery for pain control however the abuse of prescription medications has become the fastest growing drug problem in the united states. research has shown that post operative pain for some common ear, nose, and throat (ent) procedures are not severe but there is limited data looking at patient narcotic needs and their usage pattern to help inform physicians on how much to prescribe. the objective of this study is to evaluate patient pain level in the immediate post-operative period and quantify pain medication usage in patients who undergo outpatient ent surgeries. patients who undergo the following procedures will be invited to participate: thyroidectomy, parathyroidectomy, parotidectomy, tympanoplasty, mastoidectomy, endoscopic sinus surgery, and septoplasty. all patients will receive hydrocodone/acetaminophen and ibuprofen in standard dosage and assigned to one of two groups before surgery. group 1 will use the narcotic medication for pain control and ibuprofen for breakthrough pain. group 2 will use ibuprofen for pain control and the narcotic medication for breakthrough. patients will fill out a data sheet for 7 days recording their pain level three times per day as well as pain medication usage for each day. this will be collected on their first clinic visit after surgery at which point the patient's involvement is completed.

Eligibility criteria:
inclusion criteria: patients undergoing one of the following outpatient procedure: * septoplasty * unilateral or bilateral functional endoscopic sinus surgery * tympanomastoidectomy * tympanoplasty * total or partial thyroidectomy * parathyroidectomy * parotidectomy. * age \>18 years and \< 89 years exclusion criteria: * age \ 89 years * post operative hospital admission * allergy to hydrocodone * allergy or contraindication to ibuprofen or nsaids * pregnancy * hepatic disease * chronic kidney disease * sickle cell anemia

Keywords: thyroidectomy parotidectomy tympanoplasty mastoidectomy septoplasty sinus surgery postoperative pain outpatient surgery
expanded access program of sofosbuvir with ribavirin and with or without pegylated interferon in aggressive post-transplant hepatitis c

Conditions: Post-transplant Hepatitis C

Summary: this is a single arm, open-label study which will be opened at specific clinical sites at the request of an investigator for the treatment of individual subjects for whom there are no other treatment options. subjects will be treated for 24 weeks with sofosbuvir (400mg qd) with rbv; pegylated interferon may be added at the discretion of the investigator.


Eligibility criteria:
inclusion criteria: * age \> or = 18 years * previously undergone orthotopic liver transplant (olt) at least 2 months prior to the planned start of dosing * aggressive hepatitis c infection (including fibrosing cholestatic hepatitis c) * life expectancy of \< 12 months if the hcv is left untreated exclusion criteria: * history of clinically significant drug allergy to nucleoside/nucleotide analogs * participation in a clinical study with an investigational drug or biologic within 1 month prior to anticipated dose administration, unless information is available to determine that there is no safety or drug-drug interaction risk to the subject * unable or unwilling to follow the contraception requirements

Keywords: hcv sustained virologic response direct acting antiviral gs-7977 pegylated interferon ribavirin open label sofosbuvir liver transplant hepatitis hepatitis, chronic hepatitis c hepatitis c, chronic liver diseases digestive system diseases hepatitis, viral, human virus diseases enterovirus infections picornaviridae infections rna virus infections flaviviridae infections antiviral agents anti-infective agents therapeutic uses pharmacologic actions antimetabolites molecular mechanisms of pharmacological action
safety of mechanical insufflation-exsufflation and hypertonic saline

Conditions: Endotracheal Tube; Tracheostomy

Summary: conventional catheter suctioning of respiratory tract secretions is a mandatory procedure in intubated patients. poor tolerance, pain and other, sometimes severe, lung and cardiovascular complications may occur during suctioning. mechanical insufflation-exsufflation (mie), coupled with hypertonic saline (hs), may improve efficacy airway clearance and reduce risk of the maneuver. however, safety of mie and hs in intubated patients have not been studied appropriately, which justifies a randomized evaluation compared to conventional secretion suctioning.

secretion suctioning (ss) in patients with artificial airway is a mandatory procedure, although occasionally painful, not tolerated and even causing traumatic injury to the respiratory mucosa. mechanical insufflation-exsufflation (mie) and nebulized hypertonic saline with hyaluronic acid (hs-ha) have shown efficacy and safety in patients with chronic neuromuscular and pulmonary diseases, achieving aspiration and fluidification of respiratory secretions, respectively, as well as good tolerance. only anecdotal experience about the safety of mie and hs-ha in critically ill patients with artificial airway and mechanical ventilation is available. background: both mie and hs-ha facilitate the drainage of secretions from the distal airway (compared to conventional catheter suctioning, the effect of which is supposed to be limited to the trachea) both measures may prove to be efficacious in the prevention (through airway clearance of secretions) and concomitant treatment (reduction of inoculum or "draining the lung") of lower respiratory tract infections (tracheobronchitis and pneumonia).

Eligibility criteria:
inclusion criteria: * artificial airway ( endotracheal tube or tracheostomy cannula) with pressure cuff. * need for aspiration of secretions * informed consent exclusion criteria: * macroscopic hemoptysis. * acute bronchospasm * uncrontrolled muscular contractions, like tremor, myoclonus or other. * confirmed pregnancy

Keywords: respiratory secretion suctioning mechanical insufflation exsufflation hypertonic saline hyaluronic acid critically ill artificial airway
impact of dynamic coronary roadmap system for guidance of instantaneous wave-free ratio or fractional flow reserve

Conditions: Ischemic Heart Disease

Summary: in patients with 50-90% stenosis of the coronary artery, the coronary roadmap (dynamic roadmap) is performed when the conventional fractional flow reserve (ffr) and instantaneous wave-free ratio (ifr) are performed. coronary roadmap system) to confirm the effectiveness of the function.

in coronary angiography, 50% or more stenosis of the causative vessel is observed in a patient with stable angina pectoris (sap) or 50% or more stenosis of a non-causative vessel is observed in acute coronary syndrome (acs) based on 0.90, if it is less than 0.89, pci is performed, and if it is 0.90 or more, drug treatment is performed. when the pressure wire tests are performed, the pressure wire is inserted from the origin of the blood vessel through the lesion to the distal portion, and the pressure wire is placed at the distal end of the blood vessel for measurement. in this process, there are many cases where the pressure wire escapes the branch blood vessel or does not pass through well. it takes a long time to stand up and evaluate stenosis, and in many cases, an additional contrast medium is used to additionally check blood vessel travel and to check the position and condition of the pressure wire. to overcome this, the software roadmap installed in the cardiac fluoroscopy device of the cardiac catheterization room can be helpful. however, there are currently no studies related to roadmaps in coronary artery examination. therefore, in this study, we want to evaluate the effectiveness of the roadmap when examining ffr and ifr.

Eligibility criteria:
inclusion criteria: 1. patients aged 19 years or older 2. patients with stable angina, including asymptomatic ischemic heart disease, who have 50-90% stenosis of the causative vessel by coronary angiography 3. acute coronary syndrome patients with multivessel disease and 50-90% stenosis of non-caused vessels that did not cause acute coronary syndrome 4. patients who voluntarily decided to participate in this study and gave written consent to the subject consent form exclusion criteria: 1. patients with acute coronary syndrome and single vessel disease 2. patients who have undergone previous coronary artery bypass grafting 3. poor coronary blood flow (timi grade ≤ 2) 4. if life expectancy is less than one year 5. women who are pregnant or wish to become pregnant

Keywords: ifr/ffr roadmap
comparison of the effectiveness of walking back exercises and rebound therapy in cerebral palsy rehabilitation

Conditions: Cerebral Palsy, Spastic

Summary: purpose of the study: to investigate the effect of walking back exercises and rebound therapy on muscle strength, functionality, balance and aerobic capacity in children with cp implication for rehabilitation:determining the effects of rehabilitative interventions (back and forth walking exercises and rebound therapy) to be applied in children with cp with objective measurement methods (muscle us, tetrax balance system) and evaluating the effects of the results on functionality and respiratory parameters

inclusion criteria: being diagnosed with sp to be in the age range of 6-15 years, where effective communication can be provided in evaluation and treatment processes and when walking begins to mature having adequate communication skills being on level i or level ii according to gmfm no impairment in visual functions in terms of not affecting postural control responses, children with family consent study design: application of the evaluation methods specified at the beginning of the study to all 30 patients with cp who were randomly divided into 2 groups. re-evaluations were planned 8 weeks after the first evaluation of all cases who were continuing with structured neurodevelopmental treatment programs. in addition to the ongoing structured neurodevelopmental treatment programs; group 1: 12 weeks / 3 days 20 minutes walking back exercises on normal ground, group 2: rebound therapy exercises, which are arranged according to the functional levels of the cases, will be applied in 12 weeks / 3 days for 20 minutes.

Eligibility criteria:
inclusion criteria: * being diagnosed with hemiparetic sp to be in the age range of 6-15 years, where effective communication can be provided in evaluation and treatment processes and when walking begins to mature having adequate communication skills being on level i or level ii according to kmfss no impairment in visual functions in terms of not affecting postural control responses, children with family consent exclusion criteria: * orthopedic surgery and / or botulinum toxin-a application for the lower extremity in the last 6 months being at level iii, level iv or level v according to kmfss severe convulsion situations that cannot be controlled with drugs presence of a medical condition that prevents participation in the study congenital malformation conditions accompanying cp

Keywords: cerebral palsy, neurodevelopmental therapy
washed microbiota transplantation (wmt) for chronic kidney disease (ckd)

Conditions: CKD

Summary: wahsed microbiota transplantation (wmt) is a novel and promising therapeutic method for chronic kidney disease (ckd). this clinical trail aims to evaluate the efficacy and safety of wmt in the treatment of ckd.

although the therapeutic methods progress, numerous patients with chronic kidney disease (ckd) can not avoid the clinical outcome of end-stage renal disease. ckd still needs novel treatment to significantly improve the survival quality of the patients. gut microbiota has been verified to have relation with immunity. immunity plays a role in many chronic kidney disease, such as iga nephropathy, membranous nephropathy and so on. fecal microbiota transplantation (fmt) is a novel, safe, convenient therapeutic treatment which transplant gut microbiota from donor to patient to rebuild a gut microecology. this study aims to evaluate the efficacy and safety of fmt in ckd patients. patients in this study will undergo three times wmt. the primary outcome measure was the clinical remission efficacy rate in the ckd patients. the secondary outcome measure was the safety of wmt in ckd.

Eligibility criteria:
inclusion criteria: * being diagnosed with chronic kidney disease without wmt in the past three months * able to tolerate colonoscopy * receiving rescue fmt from the china microbiota transplantation system * suitable and compatible with wmt treatment * patients who can fully understand the content of informed consent for this trial and voluntarily sign a written informed consent form * able to receive follow-up examinations, follow-up examinations and retain specimens on time exclusion criteria: * patients will be excluded from the analysis if they are not followed up for at least 12 weeks post-fmt * antibiotics or probiotics within 4 weeks prior to enrollment * patients with anxiety, depression, mental or legal disabilities * patients with fulminant type, massive bloody stools, and severe illness unable to tolerate colonoscopy * other patients deemed unsuitable for enrollment by the investigator

Keywords: fecal microbiota transplantation (fmt) chronic kidney disease (ckd)