Kornimate/medical-research-clean huggingface dataset:
a two-week crossover evaluation of two hand antiseptic products on skin condition in healthy human subjects

Conditions: Healthy

Summary: evaluate the effect of two hand antiseptic products on hand skin conditions of healthy volunteers.


Eligibility criteria:
inclusion criteria: * female age 25 - 55 * subject agrees not to use any hand wash products on their hands other than what has been provided in the study. * subject agrees not to use any moisturizers or any skin products on their hands during the study * subject agrees to use gloves to protect hands from activities such as dish washing * subject is willing to sign the informed consent and hipaa * subject agrees to comply with the study requirement exclusion criteria: * subject has a history of psoriasis, active dermatitis, skin reactions, cracked, irritated, broken skin, skin infection on their hands * subject has scaly skin on hands based on visual scoring scale at day 1 * subject has a sensitivity or history of skin reactions to any study materials (eg, alcohol, chlorhexidine gluconate or zinc pyrithone or latex in the gloves) * subject has been using moisturizing products or any products on their arms and hands within 5 days prior to participation in the study * subject is pregnant * study coordinator believes the subject is unsuitable for inclusion in the study

Keywords: skin health
phase ii/iii study of wst09 in prostate cancer after radiation therapy

Conditions: Prostate Cancer

Summary: the aim of this clinical trial is to evaluate the efficacy and safety of the wst09-mediated vascular-targeted photodynamic therapy (vtp) in patients with localized prostate cancer recurrent after external radiation therapy or temporary (high dose rate, or hdr) brachytherapy.

this is a multicentre, open labelled, phase ii/iii, 6-month clinical trial with an additional follow-up at month 12, aiming to determine the efficacy and tolerability of the wst09-mediated vtp treatment. this treatment consists of an i.v. infusion of wst09 (2 mg/kg), in combination with per-cutaneous interstitial illumination using laser light (wavelength at 763nm) delivered through optical fibres positioned through the perineum in the prostatic lobes. patients who are eligible to participate in the study must have a clinically diagnosed positive biopsy of the prostate (up to stage t2b-n0-m0) diagnosed after external radiotherapy or temporary brachytherapy (no seeds), and present with increasing psa levels on three consecutive occasions (at least 3 months apart) post-radiation treatment.

Eligibility criteria:
inclusion criteria: histologically proven localized prostate cancer after receiving external radiation therapy; exclusion criteria: patients unwilling or unable to give informed consent; patients who received or are receiving chemotherapy; patients previously treated with hifu, cryotherapy, other salvage treatments, or with a trans-urethral resection of the prostate (turp); patients whose previous radiation therapy caused extensive cystitis and/or proctitis. patients suspected of disseminated intravascular coagulation (dic). patients with prior history of coronary artery disease, angina pectoris, myocardial infarction, coronary angioplasty or coronary artery bypass graft, severe valvulopathy, cardiac failure, artrial fibrillation and / or sustained arrhythmia. patients whose cardiac status does not allow general anesthesia. patients with history of thromboses or thrombo-embolisms. patients with history of stroke or transient ischemic attack.

Keywords: prostate cancer after radiation therapy
clinical prediction of post-surgical pain

Conditions: Acute Postoperative Pain; Chronic Post Operative Pain

Summary: this study aims to externally validate two clinical prediction models for moderate-to-severe acute post-surgical pain and chronic post-surgical pain. this multi-centre, prospective cohort study will be conducted in denmark and will include adult patients undergoing various types of elective or sub-acute surgical procedures.

based on sample size calculations for prediction model validation, a total of 482 patients are required validation of the acute post-surgical pain model and 748 (575 + 30% for loss to follow-up) patients are required for validation of the chronic post-surgical pain model. therefore, we will aim to recruit 748 patients in total.

Eligibility criteria:
inclusion criteria: all patients ≥ 18 years undergoing elective or sub-acute surgery exclusion criteria: cognitive impairment not allowing for informed consent

Keywords: acute postoperative pain chronic postoperative pain prediction risk tool
evaluation of the effectiveness of the combined psychological resilience and self-efficacy intervention for improving resilience and self-efficacy and reducing anxiety and depression of oesophageal cancer surgery patients

Conditions: Esophageal Cancer

Summary: the goal of this clinical trial is to evaluate the effectiveness of the combined psychological resilience and self-efficacy intervention in oesophageal cancer surgery patients. the main question it aims to answer is: is the combined psychological resilience and self-efficacy intervention program more effective than the single psychological resilience intervention in improving psychological resilience and self-efficacy and reducing anxiety and depression in patients undergoing oesophageal cancer surgery? researchers will compare the combined psychological resilience and self-efficacy intervention program to the single psychological resilience intervention and routine care to see if the combined intervention can improve psychological resilience and self-efficacy and reduce anxiety and depression in oesophageal cancer surgery patients. participants will receive the combined psychological resilience and self-efficacy intervention program in the combined intervention group, the single psychological resilience intervention in the single intervention group and routine care in the control group.


Eligibility criteria:
inclusion criteria: * diagnosed with oesophageal cancer by pathological biopsy. * received surgical treatment. * native chinese speakers and age≥18 years old. exclusion criteria: * prior to or during the first evaluation, patients who had end-stage illnesses or other chronic ailments including kidney failure, heart failure, etc.. * undergoing further supplementary therapies such as neoadjuvant chemotherapy or radiotherapy. * undergoing other systematic psychological therapies. * possess a background of psychopathy or cognitive problems. * patients\&#39; baseline anxiety and depression subscale scores are less than 8 points each.

Keywords: esophageal neoplasms; resilience, psychological; self efficacy
prophylactic iron and nutrition in preventing infant iron deficiency

Conditions: Iron Deficiency Anemia in Childbirth; Infant Nutrition Disorders; Iron Deficiencies

Summary: this study aimed to reveal the effects of prophylactic iron preparations, adequate breast milk intake, and iron-rich supplementary food intake in the prevention of ida (iron deficiency anemia) and id (iron deficiency) in infancy.

iron plays an important role in oxidation and reduction reactions, which have a very important place in the continuation of life. iron plays an essential role in these reactions because it can easily gain and lose electrons in redox reactions. iron is mostly found in the heme molecule in organisms. however, iron has structural and functional importance for many enzymes and proteins other than heme. iron deficiency (id) is the most common nutritional deficiency in children worldwide. id is more common in socio-economically developing geographies. however, it is still an important problem in developed countries. a plasma ferritin level below 12 mg/l is defined as id, which is often used synonymously with iron deficiency anemia (ida). however, id develops before anemia occurs. weakness, fatigue, tiring quickly, insomnia, and regression in neuro-cognitive functions may occur in id that precedes the signs of anemia. with the development of anemia, the clinical diagnosis of ida is fully revealed. in id that occurs in infancy, psychomotor development is adversely affected, and the development of cognitive functions slows down or even stops. immune system functions regress. although iron treatment can reverse these negative effects, some effects are permanent. therefore, prevention of id is more important than treatment. in addition, it is easier and cheaper to prevent id and ida than to treat them. it is a health policy to recommend iron prophylaxis to children aged 4-12 months in the republic of turkey. adding iron-rich foods to the diet, adequate breast milk intake, and prophylaxis with iron preparations can be used to prevent id and ida. however, there are different data in the literature on the use of prophylactic iron preparations.

Eligibility criteria:
inclusion criteria: * patients aged between 6-24 months and admitted to the general pediatrics outpatient clinic exclusion criteria: * chronic disease * blood transfusion history, * thalassemia carrier status * clinical diagnosis of infection or elevated c-reactive protein (crp) * patients who received iron deficiency or iron deficiency anemia treatment * those who were born prematurely * patients with low birth weight

Keywords: prophylactic iron infant nutrition iron deficiency prevention pediatric health
cardiovascular effects of aerobic and strength training in hypertensive middle-aged individuals

Conditions: Arterial Hypertension

Summary: systemic arterial hypertension (sah) is characterized by elevated and sustained blood pressure levels, related to several risk factors. modifying lifestyle to combat risk factors associated with cardiovascular disease is critical, as such factors are related alteration of endothelial vasodilator response leading to progressive loss of its protective function. however, endothelial dysfunction related to hypertension is not only related to the decrease in the bioavailability of endothelium relaxants, but also to the time of presence of hypertension, increased production of vessel contraction factors and oxidative stress related to the disease. in this way, physical training presents as a non-drug strategy capable of directly and indirectly influencing the pathophysiology of hypertension. in this way the objective of the present work will be to evaluate the acute and chronic effect of aerobic exercise and strength on blood pressure, blood markers of vasodilation and vascular endothelial vasoconstriction, as well as the repercussion on flow-mediated dilatation and oxidative stress markers, in middle-aged hypertensive individuals before and after 12 weeks of training. study hypothesis: the expected results of the research are that the endothelial response of biochemical markers of vasodilation and vasoconstriction will change positively after aerobic and strength training and the responses will be similar when compared between groups. there will be an improvement in the antioxidant capacity in both groups and the magnitude of the hypotensive effect will be greater in the aerobic group when compared to control and strength.


Eligibility criteria:
inclusion criteria: study inclusion criteria consisted of the following: 1) individuals should use antihypertensive medication; 2) 30-59 years of age. exclusion criteria: the following aspects were regarded as exclusion criteria: 1) body mass index (bmi) up to 40 kg/m2; 2) regular engagement in any type of physical exercise training in the past 6 months prior to inclusion in the study; 3) symptomatic peripheral arterial occlusive disease; 4) aortic insufficiency or stenosis more than stage i; 5) hypertrophic obstructive cardiomyopathy; 6) congestive heart failure (\>nyha ii); 7) uncontrolled cardiac arrhythmia with hemodynamic relevance; 7) change of antihypertensive medication in the past 4 weeks prior to inclusion in the study; 8) indication of unstable coronary artery disease. 9) use of tobacco products.

Keywords: hypertension aerobic training strength training
immune and metabolic effects of vitamin d supplementation in healthy humans

Conditions: Healthy Humans

Summary: in this placebo controlled study the investigators aim to investigate the effect of a 3 month vitamin d supplementation on parameters of the immune, endocrine and metabolic system in healthy women and men. vitamin d. in a pilot study the investigators showed an increase of certain immune cells, which regulate immunotolerance, the investigators therefore try to confirm these results with a placebo group. furthermore the investigators assess the effect of vitamin d on the glucose metabolism and hormone levels.

this is a randomized double-blind placebo controlled trial, with the aim to investigate the effect of a vitamin d supplementation on parameters of the immune, endocrine and metabolic system in healthy humans without diabetes and obesity. the primary aim is to assess the effect of vitamin d supplementation of the number and function of peripheral regulatory t-cells (tregs). the investigators will measure the tregs at baseline and monthly for 3 months. furthermore the investigators assess additional immune cells from the adaptive immunosystem. furthermore the investigators will perform a standard mixed meal tolerance test at baseline and 3 months following the supplementation in order to assess the insulin secretion in vivo.

Eligibility criteria:
inclusion criteria: * age \>= 10 years * healthy subjects without chronic disease exclusion criteria: * hypercalcemia \>2,65 mmol/l * pregnancy and lactation period * acute infections * chronic disease requiring treatment

Keywords: vitamin d deficiency autoimmune disease diabetes
study of complex intracranial aneurysm treatment

Conditions: Intracranial Aneurysm

Summary: the investigator expects that endovascular flow-diversion is superior over revascularization by postoperative modified rankin scale (mrs) in patients with complex intracranial aneurysms.

open, prospective, controlled randomized superiority trial is conducted. the hypothesis is that endovascular flow-diversion is better than revascularization in treatment of complex intracranial aneurysms by postoperative modified rankin scale (mrs). sample size was measured by fisher exact test. depending on a type of the procedure, the patients are divided into two groups: endovascular flow diversion procedure (include 55 patients) and revascularization procedure (include 55 patients). randomization is performed by random number generation.the study was approved by institutional review board

Eligibility criteria:
inclusion criteria: * anterior circulation complex intracranial aneurysm * neck is more than 4 mm wide * dome/neck ratio of aneurysm equals or less than 2:1 * age less than 75 years * ability to give informed consent (subject or legally authorized representative) * aneurysm is suitable for treatment to both procedures exclusion criteria: * subarachnoid hemorrhage less than 30 days ago * contraindications to endovascular treatment * atypical aneurysms (mycotic, flow-related in patients with avm, traumatic, false) * informed consent refusal

Keywords: intracranial aneurysm flow diverter cerebral revascularization
the effect of chiropractic thoracic manipulation on pain, depression, sleep and quality of life in patients with fibromyalgia

Conditions: Fibromyalgia

Summary: this study aimed to investigate the effects of thoracic chiropractic manipulations on pain intensity, depression levels, sleep, and quality of life in women diagnosed with fibromyalgia. the research included 50 female participants aged 25-45 who had been diagnosed with fibromyalgia between 2022 and 2023 at şişli hamidiye etfal education and research hospital. the participants were randomly divided into two groups: a chiropractic treatment group and a control group. both groups completed pre-treatment assessments using the visual analog scale (vas), beck depression inventory (bdi), pittsburgh sleep quality index (psqi), and short form 36 (sf-36). the chiropractic treatment group received thoracic chiropractic manipulations (hvla) twice a week for a total of six sessions over three weeks, while the control group received sham manipulations. a week after the final session, all participants completed the assessments again.


Eligibility criteria:
inclusion criteria: * having been diagnosed with fibromyalgia by a doctor. * having good cognitive status. * willingness to participate in the study voluntarily. * being a female aged between 25 and 45. * the symptoms persisting without any degree of improvement or decrease recently. * having dysfunction (limited movement) in the thoracic region. * having no condition that would prevent high-velocity low-amplitude (hvla) manipulation. exclusion criteria: * receiving any non-pharmacological treatment. * having heart, kidney, or liver failure. * having inflammatory, psychiatric, neurological, and/or chronic progressive systemic diseases. * pregnancy. * having a history of acute or past fractures. * malignancy history. * having a history of thoracic surgery. * having thoracic hernias, radiculopathy, motor deficits spondylosis, spondylolisthesis, narrow canal, extruded hernia, disc herniation, discitis diagnoses. * metabolic bone diseases. * infection, fever, hypotension, respiratory disorders limiting treatment application. * having a rheumatic disease (except osteoarthritis). * osteoporosis.

Keywords: chiropractic, thoracic region, pain, quality of life, depression, sleep
acute post-operative pain in colon resections

Conditions: Analgesia

Summary: objective of the study is to compare three different analgesic techniques in patients undergoing laparoscopic colon resections: peridural catheter, patient controlled analgesia of endovenous morphine and patient controlled analgesia of sufentanil sublingual tablets.

159 patients undergoing laparoscopic colon resections will be enrolled and randomized in three different groups. patients in the first group will be subjected to the positioning of a peridural catheter with a continuous infusion of ropivacaine 0,2%99 ml+sufentanil 50 mcg at an infusion rate of 4-6 ml/h. in the second group participants will receive an intraoperative bolus of morphine (0,05mg/kg) and post-operatively a patient controlled analgesia of endovenous morphine (injection dose 1 mg,lock-out 10 minutes,maximum morphine dosage for hour 4 mg). in the third group the investigators will adopt an intraoperative bouls of morphine (0,05mg/kg) and post-operatively a patient controlled analgesia of sufentanil sublingual tablets( 15 mcg, lock-out 20 minutes)

Eligibility criteria:
inclusion criteria: * age\>18 patients undergoing laparoscopic colon resections/ acceptance informed consent exclusion criteria: * contraindications to the positioning of a peridural catheter/ previous allergic reactions to the drugs used in the study/ inability of using patient controlled analgesia system
fungal infection in patients in intensive care units

Conditions: Fungal Infection

Summary: predictors of fungal infection in non-neutropenic patients in intensive care units and the aim of the study is to evaluate the frequency of fungal infection in non-neutropenic patients in intensive care units. to evaluate the risk factors of fungal infection in these patients.

the incidence of candidemia in the overall population ranges from 1.7 to 10 episodes per 100,000 inhabitants and candida is one of the ten leading causes of bloodstream infections in developed countries. an estimated 33-55% of all episodes of candidemia occur in intensive care units (icu) and are associated with mortality rates ranging from 5% to 71%. candida fungemia may have an endogenous or an exogenous origin, and in recent years a growing proportion of episodes of candidemia have been caused by candida species other than albicans. the most important independent conditions predisposing to candidemia in icu patients include prior abdominal surgery, intravascular catheters, acute renal failure, parenteral nutrition, broad-spectrum antibiotics, a prolonged icu stay, the use of corticosteroids and mucosal colonization with candida. in recent years, several studies have shown that icu patients with mucosal candida colonization, particularly if multifocal, are at a higher risk for invasive candidiasis, and that colonization selects a population amenable to antifungal prophylaxis or empirical therapy. candidemia in icus is associated with a con- siderable increase in hospital costs and length of hospital stay. invasive fungal infection (ifi) is a grave infection associated with serious effects in patients with chronic diseases including liver cirrhosis. the diagnosis of ifi re- quires histopathological evidence of tissue invasion, or isolation in blood cultures, or isolation from a normally sterile body fluid or site, with samples collected intra-op- eratively or by percutaneous needle aspiration. awareness of ifi has been increased in clinical practice with the increased survival of patients in immunocompromised states. such infections are associated with a high morbidity and significant mortality, requiring early diagnosis and appropriate treatment, but also optimal prophylaxis in patients at high risk. globally, several studies had assessed fungal infections in non-neutropenic patients, however, to our knowledge, searching for fungal infections in these patients are un- derestimated in our locality.

Eligibility criteria:
inclusion criteria: * adult patients with liver cirrhosis that will be clinically suspected to have in- fection. exclusion criteria: * age \< 18 years
pilot study of hypothermia for intracerebral hemorrhage in croatia

Conditions: Hypothermia; Primary Intracerebral Hemorrhage; Signs and Symptoms

Summary: in this pilot study the researchers will investigate efficacy of hypothermia in the early stage of treatment patients with primary intracerebral hemorrhage.

the purpose of this pilot trial is to determine whether hypothermia improves neurological outcome (measured as 3 and 6 months after the onset of symptoms using mrs, gos and bi) in patients who has suffered a primary intracerebral hemorrhage. the patients with primary intracerebral hemorrhage presented with coma (gcs ≤ 8) and ich score 2-4 will be included. induction of hypothermia will be initiated within 6 hours of symptoms onset. patients will be cooled to core temperature of 34°c during 24 hours using non-invasive temperature management (cincinnati sub-zero). the temperature will be measured continuously by esophageal system. after 24 hours of successful cooling, the target temperature will be gradually raised to achieve slow re-warming of 0.5°c / 2 h until the core temperature reaches 36,5°c. during hypothermia ecg, blood pressure, oxygen saturation and intracranial pressure will be measured continuously and registered every 30 min. the first ct scan of the brain, after initial, will be done early after normothermia is reached.

Eligibility criteria:
inclusion criteria: * gcs ≤ 8 * ich score 2-4 * symptom onset within 6 hours * ages 18 - 80 exclusion criteria: * pregnancy * hemodynamical unstability * recent myocardial infarction * systolic blood pressure \< 90 mm hg

Keywords: hypothermia, ich