Kornimate/medical-research-clean huggingface dataset:
effects of exoskeleton-assisted gait training on bone health and quality of life

Conditions: Osteoporosis

Summary: this is a randomized clinical trial to quantify the effects of exoskeleton-assisted gait on the musculoskeletal system and health-related quality of life.

investigators will test if exoskeleton-assisted ambulation confers skeletal benefits in a dose-dependent fashion. investigators also will test if reintroduction of ambulation will be associated with improvements in quality of life due to improvements in mood, pain, and functional connectivity of emotional networks in the brain.

Eligibility criteria:
inclusion criteria: * 3 years or more after injury, * non-ambulatory ais a-d spinal cord injury (c7-t12), * 158-188 centimeters tall, * weigh less than 100 kilograms, * have a modified ashworth scale (mas) score of less than 3 in both lower extremities, and * have sufficient upper body strength to complete sit to sit transfers. * women of childbearing potential must agree to use contraceptive measures during participation in the study. they also will be required to have a negative pregnancy test (urine or serum) before receiving an imaging studies. exclusion criteria: * current enrollment in another clinical trial * pregnancy * anyone with an initial blood pressure\>140/90 mmhg, orthostatic hypotension with symptomatic fall in blood pressure \>30 mmhg when upright, * an active grade 2 or greater pressure ulcer that can be worsened by walking in the device, * lower extremity contractures that interfere with the ability to wear the device, * an unhealed limb or pelvic bone fracture history of other neurological disease (e.g. stroke, peripheral neuropathy, myopathy), * active treatment for epilepsy, * current use of medications potentially affecting bone health (bisphosphonates, androgenic steroids, estrogenic steroids, lithium, glucocorticoid use for more than 3 months). * subjects with mri-incompatible implants, pumps, or neurostimulators will be excluded.

Keywords: rehabilitation bone strength quality of life
phthalate esters and childhood obesity

Conditions: Childhood Obesity

Summary: phthalate esters have been considered closely related with childhood obesity, but the existing studies revealed inconsistent results. this study was desigened to investigate the association between phthalate esters and childhood obesity in china.

the physical activity, dietary intake and the levels of urine phthalate metabolites of children were detected, and the associations between these 3 factors and childhood obesity were analyzed.

Eligibility criteria:
inclusion criteria: * children who were classified as normal, overweight and obesity based on age, gender and bmi. exclusion criteria: * the participants who were with endocrine disorders.
clinical efficacy and mechanism of yisui granule in treatment of low and medium risk myelodysplastic syndrome through demethylation

Conditions: MDS

Summary: the goal of this clinical trial is to explore the mechanism of yisui granule(ysg) in the treatment of myelodysplastic syndrome(mds) through demethylation. under the same condition of basic western medicine treatment, the treatment group used the same traditional chinese medicine decoction pieces as ysg, and the control group was given placebo. through a randomized controlled clinical study, we focused on observing the effects of mds patients on clinical symptoms (including single symptom), fatigue relief, quality of life, peripheral blood picture, blood transfusion interval and blood transfusion volume, and measured the expression of dnmts, the expression and methylation level of wnt3a、β-catenin、sfrp and other indicators, as well as cytokines, were used to explore the mechanism of ysg in the treatment of mds through demethylation.


Eligibility criteria:
a. diagnosed as myelodysplastic syndrome, ipss score 0-1; b. it meets the syndrome standard of "deficiency of both qi and yin, internal resistance of blood stasis"; c. newly diagnosed cases or no application of other chinese and western medicines or treatment schemes in the past month; d. take the test voluntarily and sign the informed consent form.
a clinical trial to evaluate the efficacy and safety of dr-3001 in women with overactive bladder

Conditions: Overactive Bladder

Summary: this is a multicenter study to evaluate the efficacy and safety of 2 different doses of dr-3001. for eligible subjects the duration of the study will be approximately 20 weeks; this will consist of a 4-week screening period, a 12-week treatment period and a 4-week follow-up period. subjects will have physical and laboratory exams, including blood draws at each scheduled visit. subjects will be required to insert a vaginal ring (replacing it every 4 weeks) and to keep a daily record of their toilet voids (including time,type and volume) for 3 days at several specified time points.


Eligibility criteria:
inclusion criteria: * women 18 years of age or older, ambulatory, with a history and presentation consistent with urge incontinence ≥ 6 months * able to distinguish between stress and urge incontinence * during the screening period able to demonstrate the presence of overactive bladder with urge incontinence based on diary entries * others as dictated by fda-approved protocol exclusion criteria: * stress incontinence, continuous incontinence or overflow urinary incontinence * chronic illness, neurological dysfunction or injury that could cause incontinence * pregnant, breastfeeding, or gave birth in the last 6 months * others as dictated by fda-approved protocol
pilot study: impact of biomarker-guided dietary supplementation on quality-of-life measures in subjects with chronic pain

Conditions: Chronic Pain

Summary: the goal of this study is to use pain-specific urine biomarkers to evaluate how daily nutritional supplementation with biomarker guided formulas effect, quality of life and urinary biomarker scores in chronic pain patients. assessing the effect of biomarker guided supplementation on pain specific biomarkers through changes in urinary biomarker scores may solidify the necessity for identifying deficiencies to create an individualized treatment plan for pain patients. this study aims to evaluate the effect of biomarker-guided supplementation on the three categories of urinary biomarkers using targeted ingredients specifically designed for oxidative stress, inflammation, and nerve health. this study provides subjects with one of three nutritional supplement formulas based on their specific urinary biomarker test results and assesses changes in their urinary biomarker levels and their quality of life as it relates to their pain over a 3-month period.


Eligibility criteria:
inclusion criteria: * previously submitted a urinary biomarker sample and agreed to be contacted for research. * be seeking treatment for chronic pain as defined as symptoms persisting for ≥ 3 months. * be able to take oral medication and/or be willing to adhere to the supplement regimen. exclusion criteria: * diagnosis of bacterial or viral infection during or 3 months prior to the study. * severe or untreated psychiatric disturbance and/or any psychiatric disorder that required hospitalization in the year prior to the screening visit. * a history of cancer within 5 years prior to screening visit. * be pregnant or breast-feeding or have plans to become pregnant at any time during the study * participant has a known sensitivity or allergy to any of the ingredients in the study products. * participant has any dietary restriction that prevents the participant from consuming any of the ingredients in the study products.
the effect of deep neuromuscular block and reversal with sugammadex on surgical conditions and perioperative morbidity in shoulder surgery using a deltopectoral approach

Conditions: Shoulder Pain; Anesthesia

Summary: the study evaluates wether deep neuromuscular block during entire surgical procedure to the gleno-humeral joint or the proximal humerus using a deltoideo-pectoral approach results in less muscular damage to the deltoid muscle and therefore less post-operative pain and an earlier functional recovery..


Eligibility criteria:
inclusion criteria: • adult patient undergoing elective or semi-elective surgery to the gleno-humeral joint or the proximal humerus using a deltoideo-pectoral approach exclusion criteria: * inability to consent because of mental status * open injuries involving the deltoid muscle * previous open surgery on the shoulder joint. * american society of anaesthesiologists (asa) physical status \>ii * age \ 85 year old * body mass index (bmi) \ 35 kg/m2 * renal insufficiency (glomerular filtration rate \<40 ml/min) * impaired liver function (hepatic cirrhosis, cholestatic jaundice) * neuromuscular disease * pregnancy * breastfeeding * predicted difficult airway * patients receiving medications known to interact with neuromuscular blocking agents * allergy to any drug included in the anesthetic protocol
weight-reduction intervention in asthmatic children with overweight/obesity

Conditions: Asthma; Overweight; Obesity

Summary: the purpose of this study is to determine the efficacy of a multifactorial intervention with weight reduction, behavioural therapy, and physical exercise on the severity and control of asthma in obese children.


Eligibility criteria:
inclusion criteria: * children aged 6-16 years * bmi in the overweight/obesity range according to data of cole et al. * asthma diagnosis exclusion criteria: * children with a normal weight according to data of cole et al. * children without any provable asthmatic complaints * congenital malformations of the airways or other chronic lung diseases like cystic fibrosis (cf) * mental retardation or syndromes * heart disease

Keywords: asthma overweight obesity children
hip arthroscopy improves muscle volumes in patients with femoroacetabular impingement syndrome

Conditions: Femoroacetabular Impingement Syndrome

Summary: to explore the changes of the muscles around the hip joint after hip arthroscopy for patients with femoral acetabular impingement syndrome.

retrospectively investigate the influence of hip arthroscopy on the muscle volume around the hip joint, and to provide important information for clinicians to make diagnosis and treatment plan of hip joint disease.

Eligibility criteria:
inclusion criteria: (1) age 18-50 years old; (2) diagnosed femoroacetabular impingement syndrome; (3) conservative treatment ineffective; (4) complete preoperative and postoperative mri images; - exclusion criteria: (1) bilateral; (2) revision; (3) osteoarthritis; (4) acetabular dysplasia; (5) history of hip and knee joint disease or surgery; (6) femoral head necrosis; (7) sacroiliac joint disease. -
a study of participants with cerebral adrenoleukodystrophy (cald) treated with elivaldogene autotemcel

Conditions: Cerebral Adrenoleukodystrophy (CALD)

Summary: the main aim of this study is to assess and describe the safety outcomes, including newly diagnosed malignancies, of patients with cald treated with eli-cel in the post-marketing setting (tradename skysona) and to describe major functional disability (mfd)-free survival over time in participants with more advanced early active cald. all enrolled participants with cald treated with eli-cel in the post-marketing setting will be followed in this study for 15 years. no investigational drug product will be administered in this study. this study will enroll 120 participants with cald treated with eli-cel in the post-marketing setting. a subpopulation of 24 participants with more advanced early active cald will be specifically enrolled as required by the us fda as a condition of accelerated approval and will be considered as a separate cohort for effectiveness outcomes.


Eligibility criteria:
inclusion criteria: participants who fulfill the following criteria will be eligible for inclusion in this registry study. * participant must be treated with eli-cel in the post marketing setting at a center in the united states (us) that participates in the registry study. * participant must have provided an informed consent and/or assent to participate in center for international blood and marrow transplant research (cibmtr) registry. * participant must have provided an informed consent and/or assent to participate in the registry study. * participant must receive follow up care by a us-based physician with the ability to submit reg-502 data. registry study subpopulation inclusion: twenty-four of the 120 patients in the registry study must meet the following inclusion criteria which will be used to create the more advanced early active cald subpopulation: • participant must meet the above inclusion criteria and have a loes score of 4.5 through 9.0 with gde+ (gadolinium enhancement positivity) from an mri performed before treatment with eli-cel and with nfs of 0 or 1 at baseline. exclusion criteria: there are no exclusion criteria for this registry study.

Keywords: adrenoleukodystrophy adrenoleukodystrophy protein
safety and efficacy study of rebamipide 2% ophthalmic suspension in patients with dry eye

Conditions: Dry Eye Syndromes; Keratoconjunctivitis Sicca

Summary: the purpose of this study is to evaluate the safety and efficacy of rebamipide 2% suspension for the treatment of patients with dry-eye.


Eligibility criteria:
inclusion criteria: * age 18 years and older * diagnosis of dry eye as defined by the protocol exclusion criteria: * ongoing ocular disease that may interfere with study parameters. * inability to stop using topical ophthalmic medications throughout the duration of the study * inability to stop the use of contact lenses for the duration of the study.
development and validation of a scale measuring preoperative expectations in parkinson's disease

Conditions: Parkinson's Disease

Summary: subthalamic nucleus deep brain stimulation (stn-dbs) has become a choice treatment for fluctuating parkinson's disease (pd) patients, inducing remarkable improvement in motor symptoms. however, as pd is a complex neuropsychiatric disease, it has been hypothesized that in some patients, non-motor features, i.e. dysfunctional expectations for the result of neurosurgery, could interfere with postoperative result of dbs, even in case of motor improvement. recent literature highlights the necessity to take these preoperative expectations into account, but to our knowledge, no specific scale investigating these cognitions in this pd-specific condition is available. so, the investigators developped the dbs-ps, a self-scale constructed to measure preoperative expectations for dbs, with 11 questions and visuo-analogical responses (1 to 10), theorically divided in three domains investigating the expectations concerning symptoms of pd, postoperative social-life and leisures, and postoperative familial and marital sphere. the investigators would like to validate this new-developped scale in the preoperative subthalamic nucleus deep brain stimulation population through patients recruited in the predistim study, whereas the investigators did not recruite sufficiently patients through the psyparkinson study, the one in which the dbs-ps scale was developed. the dbs-ps constitutes an interesting basis for the consideration of these cognitive and affective factors in preoperative pd patients.


Eligibility criteria:
inclusion criteria: * parkinson's disease patients included in the predistim study and having completed the dbs-ps scale during the preoperative phase exclusion criteria: * parkinson's disease patients not included in the predistim study or not having completed the dbs-ps scale during the preoperative phase

Keywords: deep brain stimulation preoperative expectations dbs-ps validation parkinson's disease
helmet continuous positive airway pressure (cpap) versus oxygen venturi in severe acute respiratory failure in pneumonia

Conditions: Pneumonia; Respiratory Insufficiency

Summary: the purpose of this study is to compare the efficacy of cpap application by a helmet and o2 administration by a venturi mask in terms of achievement of criteria for endotracheal intubation during severe acute respiratory failure caused by pneumonia

pneumonia is one of the commonest causes of hospitalised acute respiratory failure with a mortality rate up to 30%. continuous positive airway pressure (cpap) has ben recently proved to be effective. to date, however, no prospective randomised study has been published on the comparison between cpap and o2 administration by venturi mask for the treatment of severe acute respiratory failure in patients with pneumonia. .

Eligibility criteria:
inclusion criteria: * men and women of any ethnic group; * age ≥18 years; * dyspnoea at rest with respiratory rate (rr) ≥30 breath/min or sign of respiratory distress * pao2/fio2 ratio≤250 evaluated during oxygen therapy supplied at least 1 hour through a venturi mask with fio2 ≥0,50 * diagnosis of pneumonia as unique cause of severe acute respiratory failure * informed consent from each patient or from the closest relative in case of the patient's incapacity to give it exclusion criteria: * diagnosis of other causes of severe acute respiratory failure * unstable angina or acute myocardial infarction; * acute respiratory acidosis with ph \ 45 mmhg; * systolic bp \<90 mmhg despite fluid resuscitation or vasopressors; * severe arrhythmias; * convulsions; * degree of consciousness, kelly score\>3; * swallowing disturbance with increasing risk of aspiration pneumonia; * inability to protect the airway; * recent facial trauma or burn; * non-collaborative patient; * presence of open wounds (head, thorax, abdomen); * respiratory arrest or need of intubation; * pregnancy or suspect of pregnancy

Keywords: acute respiratory failure pneumonia continuous positive airway pressure
the change of the structure and function of taste buds after the otosclerosis surgery

Conditions: Chorda Tympani Disorder; Taste Disorders; Stapes Fixation

Summary: patients admitted for the otosclerosis operation are included in the study. the narrow band imaging (nbi) of their taste buds is performed before the operation. the sensory function of the anterior 2/3 of the tongue is tested with the two point discrimination discs, the taste is tested with taste strips and the sf-36 questionnaire is applied. during the operation in local anesthesia the threshold for the tongue sensation (by the stimulation of the chorda tympani nerve) of the first 2/3 of the tongue at the beginning of the operation (when we first encounter the chorda tympani nerve) and at the end of the operation is measured.one month and six months after the operation the tests are being repeated (nbi, two-point discrimination and sf-36 questionnaire). the study has the national ethical committee approval.

patients admitted for otosclerosis operation 18 to 65 years old, not taking medications that could influence the taste and not having the problems with the smell are being recruited for the study. the informed consent is signed by the patient. the narrow band imaging (nbi) of their taste buds is performed before the operation. the number of taste buds in the 20mm2 size area and the blood vessel morphology is being recorded. for the blood vessel morphology the five point scoring system is used. both sides of the tongue are tested separately. the sensory function of the anterior 2/3 of the tongue is tested with the two point discrimination discs. both sides of the tongue are tested separately. the taste strips are used with 4 different concentrations of sweet, sour, salty and bitter applied to each side of the tongue separately. sf-36 questionnaire adapted to slovenian language is applied. during the operation in local anesthesia the threshold for the tongue sensation at the beginning of the operation (when the investigators first encounter the chorda tympani nerve) and at the end of the operation is measured. the investigators use the facial nerve monitoring system for the measurements and stimulate directly the chorda tympani with electrical current. after each operation the surgeon determines the grade of the intraoperative manipulation of the chorda tympani nerve. one month and six months after the operation the tests are being repeated (nbi, two-point discrimination, taste testing with taste strips and sf-36 questionnaire). the study has the national ethical committee approval.

Eligibility criteria:
inclusion criteria: otosclerosis surgery - exclusion criteria: smell disturbance, taking drugs that could have the influence on taste, diseases and injuries of the tongue -

Keywords: stapedectomy taste taste buds chorda tympani narrow band imaging electrical stimulation taste strips two point discrimination quality of life
immunophenotyping of fresh stromal vascular fraction from adipose derived stem cells (adsc) enriched fat grafts

Conditions: Breast Reconstruction; Contour Irregularities; Volume Insufficiency

Summary: the purpose of this study is to investigate if there is a relationship between the take of fat grafts with and without adscs and the presence of specific surface markers on the cells of the stromal vascular fraction.

two groups of patients will be studied. the control will receive centrifuged fat grafts while the other group will receive centrifuged enriched fat grafts with adscs. the performance of both grafts will be assessed through volume measurement employing mri before and after 6 months post-op.

Eligibility criteria:
inclusion criteria: * contour irregularities and volume insufficiency in reconstructed breasts no matter the method of reconstruction employed * local flaps with conditions to receive fat grafts * good health condition exclusion criteria: * breast cancer patients under chemotherapy * smokers * bad health condition * patients too thin * patients that require a new reconstructive surgery (secondary reconstruction)

Keywords: adipocytes cell transplantations mesenchymal stem cell immunophenotyping adipose tissue breast reconstruction mammaplasty magnetic resonance imaging fat necrosis
combining transcranial direct current stimulation and core stability exercise on trunk in stroke patient

Conditions: Stroke

Summary: to evaluate the effects of the combining transcranial direct current stimulation with core stability exercises on trunk performance in poststroke hemiparetic patients, the secondary outcome is to evaluate the balance and the functional performance of the participants.

this study will conduct to 60 male and female patients with post stroke hemiparesis with age ranged between 55 to 70 years, the patients will be categorized to two equal groups. * group a (study group): will receive simultaneously a combination of transcranial direct current stimulation combined with core stability exercise. * group b (control group): will receive core stability exercise. all patients will be assessed for trunk performance, balance, and functional performance before and after interventions.

Eligibility criteria:
inclusion criteria: * patients will be included if they are ≥ 55 years old of both sex, had a first-time right or left stroke within the preceding six months that damaged the cerebral cortex verified by (computed tomography or mri report, neurological examination, and medical chart). * patients can stand and walk independently. * modified ashworth scale (mas) of upper limb muscle ≤ 1+. * all the patients received a conventional physiotherapy program in the acute stage and post-discharge from the hospital. * none of the patients participated in any other study or placebo exclusion criteria: * patients with neurological or orthopedic problems, paralysis neglect, behavioral abnormalities, dementia any shoulder dysfunction before or post-stroke (dislocation or subluxation), or those who using upper limb splints. * recurrent strokes or hemiparesis due to other neurological causes rather than stroke eg .(brain tumor). * obesity (bmi ≥ 30 kg/m2).