vaginal cleansing with chlorhexidine versus iodine for prevention of endometritis

Conditions: Endometritis; Vaginal Cleansing; Post Caesarean

Summary: povidone has been approved for vaginal cleansing in the prevention of endometritis postcaesarean section. chlorhexidine solution which is cheap and readily available as shown to prevent endometritis.the aim of this study is to compare the effectiveness of post-operative vaginal cleansing with povidone-iodine versus chlorhexidinegluconate in reducing post-caesarean maternal endometritis

background: maternal infectious morbidity is a common complication of caesarean section and is the third leading cause of maternal mortality in nigeria. it accounts for 15% of maternal death worldwide. post-caesarean maternal infectious morbidity (endometritis) is still a big challenge despite prophylactic antibiotics and other modalities adopted to prevent it. recently, preoperative vaginal cleansing with povidone-iodine was conditionally recommended in reduction of post-caesarean endometritis by who but in some emergent conditions, the practice may not be feasible. there is need to research effective post-caesarean vaginal cleansing antiseptic agents which may offer benefits in such emergent conditions. aim: to compare the effectiveness of post-operative vaginal cleansing with povidone-iodine versus chlorhexidinegluconate in reducing post-caesarean maternal endometritis at the alex ekwueme federal university teaching hospital abakaliki (aefutha). methodology: this was a single blinded randomized controlled trial involving two hundred and forty four (244) consenting pregnant women booked for emergency lower segment caesarean section at aefutha and mile 4 hospital, abakaliki; with 122 women randomized into the povidone-iodine arm (control arm) and 122 into the chlorhexidinegluconate arm. both groups received prophylactic antibiotics and anterior abdominal wall scrubbing. the control group received post-operative vaginal cleansing with povidone iodine while study group received chlorhexidinegluconate. immediately after skin closure. subsequently, they were reviewed for endometritis daily till discharge or up to 7 days for patients who had the need to stay up to 7 days or beyond. data was analyzed using statistical package for social science (ibm spss) software (version 24, chicago ii, usa). continuous variables were presented as mean and standard deviation (mean ± 2sd), while categorical variables were presented as numbers, frequencies and percentages. student t test was used for comparison between groups for continuous variables and mean of the two groups. chi-square test was used for comparison between groups for categorical variables.

Eligibility criteria:
inclusion criteria: * all pregnant women at \> 28 weeks gestational age undergoing emergency caesarean section. * emergency caesarean sections for women in labour, with ruptured membrane or cord prolapse. * pregnant women that gave consent to participate in the study exclusion criteria: * elective caesarean sections * known allergy to povidone iodine or chlorhexidinegluconate * diabetes mellitus/ glucose intolerance undergoing elective caesarean section. * asymptomatic placenta praevia undergoing elective caesarean section * patients who have chorioamnionitis * immunosuppressive conditions like aids, steroid use * patients who have coexisting uterine fibroid.

Keywords: chlorhexidine iodine endometritis post caesarean vaginal cleansing