Kornimate/medical-research-clean huggingface dataset:
pivotal study for validation of philips dx (pdx)

Conditions: Pathologic Processes

Summary: the primary objective of this study is to show safety and effectiveness of the pdx for in vitro diagnostic (ivd) use as an aid to the pathologist to view, review and diagnose digital images of surgical pathology slides.


Eligibility criteria:
inclusion criteria * all relevant coverslipped slide or slides, with human tissue obtained via surgical pathology of original case are available. * original sign-out diagnosis is available. * the selected slide or slides fulfill the quality checks according to general clinical practice. * target enrollment of organs and subtypes according pre-specified list. exclusion criteria * cases, including sent out cases, for which any of the relevant slides used for the original sign-out diagnosis is no longer available at the site. * the selected slide or slides do not match any subtype of the organ for which the case was selected. * relevant clinical information that was available to the sign-out pathologist in the pathology request form cannot be obtained. * selected slides contain indelible markings. * selected slides with damaged tissue. * more than one case was selected for a patient (only one case may be enrolled per patient). * case consists of frozen section(s) only. * case consists of gross specimens only.
comparison of long-term safety of the combination product qva149a against placebo and standard of care treatment in chronic obstructive pulmonary disease patients with moderate to severe airflow limitation

Conditions: Chronic Obstructive Pulmonary Disease (COPD)

Summary: the study will assess the long-term safety of the fixed combination product qva149 versus placebo and a standard of care treatment (tiotropium) in chronic obstructive pulmonary disease (copd) patients with moderate to severe airflow limitation.


Eligibility criteria:
inclusion criteria: * male and female adults aged ≥40 years. * patients with stable copd according to gold strategy (gold 2011). * patients with airflow limitation indicated by a post-bronchodilator fev1 ≥ 30% and \<80% of the predicted normal, and a post-bronchodilator. * fev1/fvc \< 0.70. * current or ex-smokers who have a smoking history of at least 10 pack years. * patients with an mmrc ≥ grade 2 exclusion criteria: * history of long qt syndrome or prolonged qtc. * patients who have had a copd exacerbation that required treatment with antibiotics and/or systemic corticosteroids and/or hospitalization in the 6 weeks prior to visit 1. * patients with type i or uncontrolled type ii diabetes. * patients with a history of asthma or have concomitant pulmonary disease. * patients with paroxysmal (e.g. intermittent) atrial fibrillation. only patients with persistent atrial fibrillation and controlled with a rate control strategy for at least six months could be eligible. * patients who have clinically significant renal, cardiovascular, neurological, endocrine, immunological, psychiatric, gastrointestinal, hepatic, or hematological abnormalities which could interfere with the assessment of safety.

Keywords: chronic obstructive pulmonary disease copd qva149 qab149 nva237 indacaterol maleate glycopyronnium bromide
laser acupuncture on irritable bowel syndrome in females

Conditions: Constipation-predominant Irritable Bowel Syndrome

Summary: the aim of the study to investigate effect of laser acupuncture on constipation predominant irritable bowel syndrome in female patients

irritable bowel syndrome (ibs) is a common chronic functional gastrointestinal disorder characterized by recurrent abdominal pain and/or bloating related to defecation without reliable biological markers . ibs is associated with substantial burden, such as higher levels of anxiety, lost productivity at work, work absenteeism (pimentel, 2018). ibs has a strong predominance in women ibs-c includes a wide range of symptoms, and its pathophysiology is complex and not fully understood. visceral hypersensitivity and delayed gut transit are recognized as major pathophysiological mechanisms in ibs-c. visceral hypersensitivity may account for symptoms of abdominal pain, bloating, and discomfort. delayed gut transit causes constipation the unsatisfactory treatment responses and adverse effects associated with pharmacologic therapies have resulted in a higher demand for alternative therapies acupoints and manipulations are the same in both the experimental and the control groups. the participants in the control group will receive sham laser acupuncture treatment, without any laser output, while the participants in the experimental group will sequentially receive 0.375j of energy at each of the following acupoints: baihui (gv20), yintang (gv29), taichong (lr3), zusanli (st36), sanyinjiao (sp6), tianshu (st25), and shangjuxu (st37) acupoint .using a gallium aluminum arsenide laserpen (maximal power, 150 mw; wavelength, 810 nm; area of probe, 0.03 cm2; power density, 5w/cm2; pulsed wave; and bahr frequencies \[b1: 599.5hz, b2: 1199hz, b3: 2398hz, b4: 4776hz, b5: 9552 hz, b6: 19,104hz, and b7: 38,208hz\]. the laser treatment will be applied to each point for 5 seconds, to deliver a total treatment dose of 4.5j/cm2 . intervention will be 3t/ week for 6 weeks in both groups.

Eligibility criteria:
inclusion criteria: * all participants will meet diagnostic criteria (rome iv) for ibs-c * their age will range from 20-35 years old * their body mass index (bmi) will range from \>18.5kg/m2 and \<29.9kg/m2 exclusion criteria: * taking medications known to cause constipation * any organic diseases that might induce constipation such as colorectal cancer, metabolic disorders, multiple sclerosis, or neurological disorders * organic diseases of the small or large intestine such as ulcerative colitis and crohn's disease * a history of gastrointestinal surgery (other than appendectomy or cholecystectomy) * mechanical obstruction * serious concomitant disease of the heart, liver, or kidney or diabetes * pregnant or lactating women * severe psychiatric disorders * knowledgeable of acupoints and meridians that might unblind the treatment.
effect of umbilical cord milking on transition of preterm babies during resuscitation

Conditions: Fetal Distress

Summary: investigators will evaluate if milking of umbilical cord in preterm babies will improve transition during resuscitation or not

investigators will make milking for 100 preterm babies and placed them on warmer and assess heart rate,blood pressure,oxygen saturation,fio2,maximum pip,peep and 100 babies other without milking to see the difference between two groups.

Eligibility criteria:
inclusion criteria: * babies who need resuscitation * preterm babies with 28-34 weeks gestatinal age exclusion criteria: * preterm babies above 34 weeks gestational age, -- - * refusal by mother or obestatracain, -- -babies with congenital anomalies
quantitative renal uptake using tc99m dmsa in hypertensive &/or diabetic patients.

Conditions: Diabetes Mellitus; Hypertension

Summary: the investigators explore the possible role of dmsa to detect renal affection in diabetic \&/or hypertensive patients by detecting difference in counts using tc 99m dmsa in control \& diabetic \&/or hypertensive patients.


Eligibility criteria:
inclusion criteria: * • patients with diabetes (type2), weather controlled or not. * patients with essential hypertension. * patients with diabetes \& hypertension. * within normal renal function (urea \& creatinine). * control cases may be normal individuals (apparently healthy) like donors for renal transplant. exclusion criteria: * • patients with abnormal renal function. * patients with diseases known to affect kidney function rather diabetes \& hypertension e.g. sle, heart failure or liver cell failure.
tension of theraband® kinesiology tape on shoulder pain

Conditions: Shoulder Pain

Summary: the purpose of this study is to determine the effectiveness of standard tension of thera-band® kinesiological tape (tb-kt) application versus varied tension on shoulder pain, disability, and recovery speed during an in-office rehabilitative program. a convenience sample size of 38 new patients with current shoulder pain will be recruited for this study. the outcome measures will include the numeric pain rating scale (nprs) and the penn shoulder score (penn). after completing the initial paperwork, patients will be randomized into two groups, control (0% tension) and intervention(increasing tension). at the beginning of each week the tape will be reapplied, and pain rating will be recorded. at the conclusion of 4 weeks patients will complete the penn.

the purpose of this study is to determine the effectiveness of standard tension of thera-band® kinesiological tape (tb-kt) application versus varied tension on shoulder pain, disability, and recovery speed during an in-office rehabilitative program. a convenience sample size of 38 new patients with current shoulder pain will be recruited for this study. patients must be tested within the first 2 to 3 therapy visits, have a diagnosis of shoulder pain, be 18-64 years old, no corticosteroid treatment within the last two weeks, post-surgical cases will be excluded, and patients may not be pregnant. upon agreeing to the study, patients will sign an informed consent, complete a demographics questionnaire, and complete specific outcome measure assessments. the outcome measures will include the numeric pain rating scale (nprs) and the penn shoulder score (penn). after completing the initial paperwork, patients will be randomized into two groups, control and intervention. the control group will receive standard funhab® in-office care in addition to standard tb-kt taping technique. the intervention group will receive standard funhab® in-office care plus varying tension application of tb-kt. the tb-kt will be applied to the shoulder complex to influence proper activation of the rotator cuff muscles, specifically the supraspinatus and infraspinatus. the tape will be applied in an "i" strip from the vertebral border of the scapula to the lesser tubercle of the humerus. over the course of the 4 weeks, the tension of the tape will systemically increase. at the beginning of each week the tape will be reapplied, and pain rating will be recorded. at the conclusion of 4 weeks patients will complete the penn.

Eligibility criteria:
inclusion criteria: * tested within the first 2 to 3 therapy visits, have a diagnosis of shoulder pain, and be 18-64 years old exclusion criteria: * corticosteroid treatment within the last two weeks, post-surgical cases, and pregnancy

Keywords: shoulder dysfunction kinesiology tape rehabilitation
osteochondral allograft in the surgical treatment of basal joint arthritis

Conditions: Basal Joint Arthritis

Summary: this is a study comparing the current standard of care surgical treatment to a newer surgical procedure involving the implantation of osteochondral allograft at the base of the thumb. patients will be followed at 1, 3, 6 months and 1 year post-operatively.

basal joint arthritis of the thumb is a common condition associated with considerable morbidity. many non-operative and operative treatments have been described, but few multicenter prospective evidence based trials exist comparing standard treatments. this continuing search for consensus and improvement of best clinical practice has been reviewed in a thorough meta-analysis of operative treatments for basal joint arthritis. operative treatments range from osteotomy, partial or complete trapeziectomy with or without reconstruction of the ligaments, tendon interposition to arthrodesis, however the functional outcome varies. allograft has been previously described in joint replacement / prosthetic implantation surgery in other areas of the body, however not in the thumb. the purpose of this study is to investigate using osteochondral allograft in the surgical intervention phase of treatment for patients with basal joint arthritis.

Eligibility criteria:
inclusion criteria: * 18 years of age or older * indicated for operative management of basal joint arthritis exclusion criteria: * pregnant women/fetuses/neonates, prisoners * previously operated on for treatment of basal joint arthritis

Keywords: allograft osteochondral allograft arthritis
a pilot study of changing medication adherence in hypertensive african-american patients

Conditions: Hypertension

Summary: we will conduct an empirical test of the two intervention approaches under study. specifically, we seek to determine the potential differential impact of positive affect induction and self affirmation.

we are interested in achieving an empirical test of the two intervention approaches under study. specifically, we seek to determine the potential differential impact of positive affect induction and self affirmation following the qualitative phase. 1. positive affect induction: we will tests two types of positive affect induction. 1) sending patients a small gift, and 2) reminding patients of positive thoughts about themselves. gift: prior to a telephone call, patients in the positive affect condition will receive a small gift. positive thoughts about themselves: patients will be asked to describe a time when someone was helpful to them, and they felt good about it , and were nice to them in return. 2. self affirmation: consists of a series of items reminding people of their core values. 3. control: control patients will have neither self affirmation nor gifts. follow-up: at two weeks after enrollment all patients will be called to ascertain impact of the pilot intervention.

Eligibility criteria:
inclusion criteria: 1. patients must be self-identified as african-americans. 2. all patients must be aged 18 years and older. 3. all patients must be diagnosed as having hypertension: for this project, hypertension will be defined according to the widely accepted criteria of the 6th joint national committee (jnc vi) guidelines on prevention, detection, evaluation and treatment of hypertension, which is a systolic blood pressure \> 140 mm hg or a diastolic blood pressure \> 90 mm hg or if participants are taking any prescribed antihypertensive medication. 4. patients must be able to provide informed consent in english. exclusion criteria: 1. patients who are unable to walk several blocks for any reason. 2. patients who refused to participate 3. patients who are unable to provide informed consent.

Keywords: african-american hypertension medication adherence risk reduction
a trial of the launching! to adulthood program

Conditions: Autism Spectrum Disorder (ASD)

Summary: the purpose of this study is to evaluate the effectiveness of the launching intervention (pagan et al., 2024) in improving adaptive functioning, transition readiness, and social cognition in young adults with autism spectrum disorder (asd), compared to a delayed treatment control group, to examine whether the launching intervention leads to improvements in executive functioning, co-occurring mental health symptoms, and quality of life, as measured by caregiver and self-report assessments, to assess the maintenance of treatment gains 12 weeks post-treatment and to replicate the findings of the launching pilot study in an independent sample of young adults with asd.


Eligibility criteria:
inclusion criteria: * confirmed case of asd from a licensed mental health or medical professional * score of \>14 on the social communication questionnaire-lifetime (scq-l) completed with the mother or father * meet dsm-5 criteria for asd based on a diagnostic and statistical manual of mental disorders (dsm-5) asd symptom checklist * willing and motivated to participate in the treatment * a parent willing to participate * verbal intelligence quotient (iq) score \>70 as assessed by the kaufman brief intelligence test 2nd edition revised (kbit-2-r) exclusion criteria: * history of a psychotic disorder or current psychotic symptoms * suicidal ideation with intent or plan * current alcohol or other substance use disorder rated severe * concurrent enrollment in another clinical trial for autism spectrum disorder * expression of unwillingness to complete study procedures

Keywords: launching intervention
effects of balloon-blowing exercises in 90/90 bridge position with a ball on pulmonary function among asthmatic patients

Conditions: Asthma

Summary: in asthma, the airways in the respiratory system can experience inflammation and constriction, causing increased difficulty in expelling air during exhalation. this results in disruptions to respiratory parameters, exercise intolerance, and a diminished overall quality of life.engaging in balloon-blowing exercises while in a 90/90 bridge position with the use of a ball will lead to enhanced pulmonary function and quality of life in individuals with asthma.

asthma attacks and labored breathing can cause strain and weakness in the diaphragm, the main muscle supporting breathing, as well as the muscles of core. the study objective is to determine the effects of balloon-blowing exercises in 90/90 bridge posotion with a ball on pulmonary function and quality of life among asthmatic patients.

Eligibility criteria:
inclusion criteria: * adults: aged (18-59 years) * gender: both male and females * grade1- grade 4 on modified mrc dyspnea scale * asthma severity ( level 1 mild intermediate, levell 2 mild persistent) exclusion criteria: * level 3 and above asthmatics or status asthmatics. * any congenital deformities of chest wall/ heart/ lungs. * demonstrated neuromuscular or neurological deficit/ chest wall deformity. * cardiopulmonary diseases including coronary artery disease(cad), pulmonary htn, ------aortic stenosis, regurgitation, etc. * any autoimmune disease with manifestations of chest wall/ heart/ lungs. * any recent cardiothoracic or abdominal surgery or sternotomy. * recent history of the blunt chest wall or abdominal trauma. * unstable hemodynamic parameters (arterial pressure \>140mmhg systolic and \>90mmhg for diastolic). * pregnancy

Keywords: dyspnea, asthma, spirometry, quality of life, oxygen saturation
reducing ptsd in hospitalized burn patients

Conditions: Posttraumatic Stress Disorder

Summary: the investigators propose to develop and pilot-test a short-term cognitive-behavioral treatment (cbt) for hospitalized survivors of acute burns, in order to reduce posttraumatic symptoms before they consolidate into long-term posttraumatic stress disorder (ptsd). this is important because approximately one third of burn survivors develop ptsd after discharge. ptsd is associated with extended psychological suffering and a greater need for medical services in the future. although there are treatments for chronic ptsd, there are far fewer interventions available to treat acute posttraumatic symptoms before they develop into this disorder, and none to date has focused on adult burn survivors. the little research available on other forms of trauma suggests that interventions developed to treat ptsd may be helpful in preventing ptsd when used in the first weeks following a trauma. the investigators will develop a six-session intervention package for use with patients at the los angeles county + university of southern california burn center. the intervention will translate cbt principles that have been validated with trauma survivors, but will be adapted to hospitalized burn patients. after manual development, we will pilot-test this treatment on 15 patients who are medically stable, and not critically ill, intubated, or delirious. treatment will consist of three 50-minute cbt sessions per week, involving mindfulness-focused relaxation training, graduated exposure to memories of the burn, psychoeducation, and cognitive restructuring. assessment will include standardized tests of posttraumatic stress, anxiety, and depression, administered at the initiation and termination of treatment, and at one-month follow-up. also assessed will be number of hospital days to discharge and participant satisfaction with treatment. we will evaluate the overall feasibility of conducting a study on ptsd prevention in burn survivors, as measured by initial recruitment success, subsequent dropout rates at the end of treatment and at the one-month follow-up, and participant satisfaction. these data will then be used to support a subsequent application for funding of a larger-scale randomized clinical trial (rct) study.


Eligibility criteria:
inclusion criteria: * male \& female patients at the lac+usc medical center burn center * 18 years of age or older * english-speaking, able to read \& write english * expected by the treatment team to require at least 2 weeks of hospitalization * willing to participate exclusion criteria: * patients who are critically ill; intubated; unable to converse; or delirious * cognitively impaired or mentally retarded * severely depressed or suicidal * psychotic; manic or hypomanic due to a bipolar affective disorder * currently demonstrating withdrawal from alcohol or other substances * patients whose physical pain level requires medications that would cognitive impair him or her to the point of diminished or impaired functioning

Keywords: stress disorders post-traumatic burns brief psychotherapy cognitive behavior therapy
prevalence and seroconversion of covid-19 in autoimmune diseases in europe

Conditions: COVID-19; Systemic Lupus Erythematosus; Sjogren's Syndrome; Axial Spondyloarthritis; Rheumatoid Arthritis; Giant Cell Arteritis

Summary: the coronavirus disease 2019 (covid-19) pandemic is a potentially fatal disease that represents a great global public health concern. in european countries such as spain, italy, germany, portugal, england and france, the pandemic has been of utmost importance. to date, no treatment has been robustly validated, and two theoretically opposite therapeutic strategies are proposed, based either on antiretroviral therapy or on immunomodulating agents. in this complex context, people living with immune-mediated inflammatory diseases (imid) raise specific concerns due to their potentially increased risk of infections or of severe infections. among imid, sjögren's syndrome, systemic lupus erythematosus, rheumatoid arthritis, spondyloarthritis and giant cell arteritis are some key diseases. in this cross-sectional, observational, multi-centric study, the investigators aim to assess both clinical and serological prevalence of covid-19 among samples of imid patients in europe. in parallel, the investigators aim to compare the prevalence of covid-19 seroconversion across these five imids, their penetration across different 6 european countries (france, italy, spain, germany, united kingdom and portugal), and to assess the severity of covid-19 in these patients. moreover, changes in treatment will be assessed, including immunomodulatory tapering or discontinuation, its causes over the outbreak period, as well as the incidence of imid flares and their severity over this same period. finally, patient's perceptions towards the pandemic will be evaluated and compared to medication beliefs. data will be collected through questionnaires during medical visit or phone consultation and serological tests will be performed within routine blood collection. as so, all study procedures are comprised within usual care. through this study the investigators expect to have a better knowledge of the clinical and serological prevalence of covid-19 in imid across europe, along with the psychological, clinical, and therapeutic impact of covid-19 in this particular patient population.


Eligibility criteria:
inclusion criteria: * age \> 18 years; * patients fitting classification criteria for each imid (i.e., sjögren's syndrome, systemic lupus erythematosus, rheumatoid arthritis, axial spondyloarthritis or giant cell arteritis); * willingness to participate; * there are no specific inclusion criteria based on imid previous activity, treatment or known covid-19. exclusion criteria: * patients who refuse to participate; * patients who don't speak or read the local language, * patients unable to perform a routine blood collection during the study period

Keywords: covid-19 systemic lupus erythematosus sjogren's syndrome axial spondyloarthritis rheumatoid arthritis giant cell arteritis prevalence