Kornimate/medical-research-clean huggingface dataset:
muscle function after intensive care

Conditions: Critically Ill; Colorectal Surgery; Healthy; Muscle Strength

Summary: final objective of critical care is no longer only survival. the role of medical and paramedical teams should also be to restore functional capacities, autonomy and quality of life. what has been call "intensive care unit - acquired weakness" (icu-aw) is associated to acute and long term increased mortality, prolonged icu and hospital stay, prolonged duration of mechanical ventilation, altered quality of life in survivors and increased health-related costs. in order to target efficient secondary prevention and early rehabilitation, prompt identification of muscle weakness is crucial. several methods, aiming to assess muscle mass, muscle strength or physical function, are described. manual muscle testing using the medical research council (mrc) scale is still the most commonly utilized tool to diagnose icu-aw (mrc \<48/60). dynamometry is an objective alternative and one of the most accurate clinimetric tool to assess muscle strength. literature is overflowing with insufficiently standardized dynamometry data. using the investigator's published standardized protocol of quadriceps strength (qs) assessment, this observational study aim to describe physical performances of cc patients and thus to define the weakest ones, by comparing them to surgical and healthy subjects.


Eligibility criteria:
inclusion criteria: * collaborative icu patients with length of stay \> 48h * surgical patients scheduled for colorectal surgery * healthy subjects exclusion criteria: * a score \> 1 or \< -1 on the richmond agitation and sedation scale (rass) * coma * total hip or knee arthroplasty in the dominant limb * unauthorized support on the dominant leg * open wound located at the ankle's anterior face of the dominant leg * pre-existing myopathy or polyneuropathy * para- or tetraparesis, para- or tetraplegia * refusal.
functional evaluation after maxillectomy and scapular free flap reconstruction

Conditions: Maxillary Sinus Squamous Cell Carcinoma

Summary: the goal of the study is to analyse the functional and aesthetic outcomes after removal of the maxillar bone and reconstruction with part of the scapular bone for people having maxillary tumor


Eligibility criteria:
inclusion criteria: * patient with maxillary sinus tumor * treated by maxillectomy with free scapula tip flap reconstruction * 18 years of age or older exclusion criteria: * reconstruction failure * carcinomatous recurrence and/or further progression impacting quality of life * death

Keywords: maxillectomy reconstruction scapula tracheotomy functional aesthetic
emergency department (ed) flow-directed fluid optimization resuscitation trial (effort)

Conditions: Shock

Summary: the short term goal of this study is to evaluate a non-invasive approach that optimizes intravenous (iv) fluid administration according to heart performance and results in surrogate improvements in morbidity and mortality via lactate clearance. additional objectives include comparative assessments of methods for determining volume responsiveness and establishing a prevalence of volume responsive shock in the emergency department (ed).

patients will be randomized to routine care (rc) or fluid optimizations (fo) arms. both arms will have interval cheetah nicom® (non-invasive cardiac output monitoring) passive leg raise testing (plrt). in the fo arm, patients having a plrt demonstrating a \>/= 15% change in stroke volume index (svi) or cardiac index (ci) patients will receive a 500ml normal saline bolus. if the nicom® plrt shows a svi or ci \<15% patients will receive a saline lock. if bolused, nicom® plrt will be performed within 10 minutes after the bolus with the decision to re-bolus or saline lock according to repeated nicom® plrt measurements. if saline locked, nicom® plrt will be performed every 30 minutes with the decision to re-bolus or saline lock according to repeated nicom® plrt measurements. in the rc arm, iv fluid administration will be per the treating clinicians discretion. the cheetah nicom®plrt will be performed before and after each clinician fluid bolus. lactate blood samples will be drawn at time zero, 1 hour, 3 hours, 6 hours, and/or ed departure and compared between arms.

Eligibility criteria:
inclusion criteria: * hypotension (systolic blood pressure ≤90mm hg or mean arterial pressure ≤ 65 mm hg) after ≥ 20ml/kg fluids or * vasopressor use or * lactate ≥ 2.5 mmol/l exclusion criteria: * pulse oximetry \<90% despite supplemental oxygen or intubation * seizure in the last 24 hours * prisoner * pregnancy * age \<18 * allergy to coupling or ultrasound gel * inability to do passive leg raise * inability to obtain iv access * treating clinician discretion

Keywords: shock resuscitation hemodynamics emergencies critical care lactic acid plasma volume
determinants of mercaptopurine toxicity in paediatric acute lymphoblastic leukemia maintenance therapy

Conditions: Acute Lymphoblastic Leukemia

Summary: the present study was conducted to assess the population pharmacokinetics of 6-mercaptopurine (6-mp) in pediatric acute lymphoblastic leukemia (all) and genetic polymorphisms

the investigators' purpose was to identify genetic factors and metabolite concentrations associated with both hematological toxicity in patients with all maintained on 6-mp in chinese.

Eligibility criteria:
inclusion criteria: * patients have been diagnosed with acute lymphoblastic leukemia * childhood patients who were undergoing chemotherapy or continuous follow-up after completion of chemotherapy * patients received the phase of maintenance therapy that included oral 6-mp (\>4 weeks) and completion of ≥ 6 months according to the cclg (chinese children's leukemia group) protocol-all 2015 exclusion criteria: * patients with high-risk all (presence of higher-risk features: mrd ≥ 1% at 46 day, or age \< 6 month and white blood cell (wbc) count ≥ 300×109/l with translocations t(9;22) (q34;q11) \[bcr-abl\], t(4;11) (q21;q23) \[af4/mll\], t(1;19) (q23;p13) \[e2a-pbx1\] or other mll-rearrangements) were removed
comparing mescaline sodium enteric-coated tablets vs morte-mescaline in the treatment of adult lupus nephritis

Conditions: Lupus Nephritis

Summary: the goal of this prospective, multicenter,real-world study is to to evaluate the efficacy and safety of mescaline sodium enteric-coated tablets versus morte-mescaline in the treatment of adult patients with lupus nephritis under real-life medical conditions. the main question it aims to answer are: is the efficacy of mescaline sodium enteric-coated tablets in the treatment of adult patients with lupus nephritis not inferior to morti-mescaline？ participants will receive induction and maintenance treatment with mescaline sodium enteric-coated tablets and morte-mescaline.then participants will be followed up at 60, 180, 270 and 540 days of treatment to assess the efficacy and safety of mescaline sodium enteric-coated tablets compared to morte-mescaline.


Eligibility criteria:
inclusion criteria: * 1. age 18-70 years; 2. meet the 2019 sle classification criteria established by eular/acr; 3. have any of the following clinical and laboratory abnormalities: 1) proteinuria \>0.5 g/24h, or urine protein ++++ on random urinalysis, or urine protein/creatinine ratio ee \>500 mg/g (50 mg/mmol); 2) cellular tubularity including erythrocyte tubularity, hemoglobin tubularity, granular tubularity, tubular tubularity, or mixed tubularity; 3) active urinary sediment (except 3) active urine sediment (except urinary tract infection, urine leukocytes \>5/hpf, urine red blood cells \>5/hpf), or erythrocyte tubular, or leukocyte tubular; 4. 24h urine protein quantification ≥ 1.0 g; 5. require long-term treatment with mpa-type drugs (mescaline sodium enteric-coated tablets or morte-mescaline); 6. singed the informed consent. exclusion criteria: * 1. patients treated with immunosuppressive agents (e.g. ctx, mpa, cni, etc.) within 30 days 2. patients with co-morbid severe cns infections 3. neutrophil counts \ 1.5 x upper limit of normal (uln); 6. pregnant or lactating women 7. presence of other major diseases such as tumors, hiv viral infections, systemic bacterial/fungal/viral infections; 8. presence of contraindications to glucocorticoids and investigational drugs 9. any condition that, in the judgment of the investigator, is unstable or may jeopardize the safety of the subject and his or her compliance with the study.

Keywords: lupus nephritis mescaline sodium enteric-coated tablets morte-mescaline
functional brain imaging and employment in first-episode psychotic patients treated with risperdal

Conditions: Schizophrenia

Summary: assured treatment with risperal consta will provide first-episode patients, who have a greater potential for therapeutic response, with their best opportunity for continued improvement in cognitive function beyond three months of treatment.

first episode patients have a greater potential for therapeutic response than multi-episode patients, and many of them also havea great desire to rejoin the workforce. unfortunately, first episode patients become non-compliant or intermittently compliant with prescribed antipsychotic treatment at least as frequently as multi-episode patients. we believe that assured treatment with risperal contsta will provide first episode patients wiwth their best opporutnity for continued improvement in cognitive function beyond 3 months of treatment and that improvements in cognitive function will be associated with a greater likelihood of employment, real-world outcomes, such as independent living, as well as measures of brain function.

Eligibility criteria:
inclusion criteria: * male or female between 18-40 years of age * meet dsm-iv criteria for first-episode schizophreniform, schizophrenia or schizoaffective disorder exclusion criteria: * pregnant \& breast-feeding women * patients with known sensitivity to oral risperdal

Keywords: schizophreniform; schizophrenia; schizoaffective disorders
amendtm mitral valve repair system, annuloplasty ring applied in a transcatheter method

Conditions: Mitral Regurgitation

Summary: a multi center study to evaluate the safety of the amendtm mitral valve repair system and its ability to reduce mitral regurgitation. amend device is an annuloplasty ring implanted in a minimally invasive trans-catheter method.


Eligibility criteria:
inclusion criteria: * patient age ≥18 * the patient requires mitral valve annuloplasty for mitral regurgitation without the need for concomitant cardiovascular surgical procedures * nyha functional capacity ≥2 * the subject is high risk to undergo a mitral valve surgery as assessed by the center heart team * the patient is willing to comply with study procedures and is available to return to the implant center for follow-up visits. * the patient is willing to provide informed consent exclusion criteria: * cardiac or non-cardiac major or progressive disease, which in the investigator's discretion produces an unacceptable increased risk to the patient. * life expectancy of less than twelve months. * heavily calcified annulus or leaflets. * previous or active endocarditis. * active infection. * a previously implanted prosthetic mitral valve or annuloplasty ring/band. * the patient is contraindicated to general anesthesia. * pregnant (urine hcg test result positive) or lactating patient. * drug or alcohol abuse. * participation in concomitant research studies of investigational products that will interfere with the study.
seroprevalence of hepatitis b and immune response to hepatitis b vaccination in chinese college students

Conditions: Hepatitis B; Immune Response; Seroprevalence

Summary: at present, children less than 15 y of age have been regarded as a key group for hepatitis b immunization in china. however, there is not yet special immunization strategy for population above 15 y of age. in this study, we investigated the seroprevalence of hepatitis b and immune response to hb vaccine among chinese college students to uncover the need on universal mass vaccination or booster immunization only for students with hbv vaccination history against hepatitis b in chinese college students to inform decision making.


Eligibility criteria:
inclusion criteria: * male and female freshmen in one college in liuzhou city of guangxi zhuang autonomous region exclusion criteria for vaccination study: * acute illness * immunocompromised conditions * renal insufficiency * pregnancy * allergic history to hb vaccine or yeast * positive for any of hbsag, anti-hbs or anti-hbc
potential benefits of home based exercise programs in the management of spastic cerebral palsy

Conditions: Cerebral Palsy, Spastic, Diplegic

Summary: the study will be conducted to see the potential benefits of home based exercise program comprising routine physical therapy and traditional massage in the management of spastic cerebral palsy (cp). it will be a randomized controlled trial having two groups, rpt group and massage group. both groups will be provided with routine physical therapy treatment comprising stretching of spastic muscles, strengthening of weak muscles, positioning and posturing strategies. massage group will also receive traditional massage in addition to routine physical therapy. parents/caregivers will be trained to perform routine physical therapy and traditional massage at home. data will collected using a structured questionnaire, modified ashworth scale (mas), gross motor function measure (gmfm),gross motor function classification system (gmfcs) and cp child's caregiver priorities \& child health index of life with disabilities at baseline, after 6th and 12th weeks of intervention.

cp is among the most common type of physical disabilities presenting itself in children across the globe. although its incidence range has been reported from 2 to 2.5 cases per 1000 live births globally, however it may be many folds in poor counties due to lack of reporting and absence of cp registries at national level . many interventions are in use to manage the disabling and lifelong consequences of this condition. however majority of these interventions remain beyond the reach of poor population especially in under developed countries with poor socio-economic status like pakistan. this creates a need for search to such interventions which should be locally available, accessible, low cost, affordable, and doable by the poor population so that disabling consequences of this condition may be minimized. rpt and traditional massage performed by parents at home after proper training fall in the category of such low cost interventions. hence there is dire need to investigate the potential benefits of such interventions. that is why this rct has been planned.

Eligibility criteria:
inclusion criteria: * child should have established diagnosis of spastic cerebral palsy (diplegic types only). exclusion criteria: * children having moderate to severe contractures. * children having moderate to severe mental retardation and with multiple disabilities. * children with attention deficit hyperactive disorder (adhd), uncontrolled seizures and behavioral disorders

Keywords: cerebral palsy, massage, spasticity, motor function
12-week exercise-based program in myocardial revascularization subjects

Conditions: Quality of Life

Summary: to determine if a 12-week physical exercise program (12-wpep), after percutaneous coronary intervention (pci) or coronary artery bypass graft (cabg) with different left ventricular ejection fraction (lvef) might improve the health-related quality of life (hrqol).

percutaneous coronary intervention (pci) and coronary artery bypass graft surgery (cabg) are interventions that can reduce cardiovascular symptoms such as dyspnea and angina. the life quality and the functional capacity improved in the subjects who underwent surgery. however, new cardiac events, death and obstruction of the bypass placed can exist. to diminish these risks, national and international guides recommend cardiac rehabilitation (cr) for people with coronary disease, who have suffered a myocardial infarction and are subjected to cabg and pci. a 20-30% reduction of morbidity and mortality can be obtained with the use of cr. according to the european society of cardiology (esc), the american heart association (aha) and the american college of cardiology (acc), cr is a recommendation class type i, in subjects treated with pci and cabg. this includes prescribed physical exercises, education, and counseling to modify the effects of coronary heart disease and improve long-term survival. exercise-based cardiac rehabilitation is an effective and safe therapy to be used in the management of clinically stable patients following pci or cabg. the maximum oxygen uptake (vo2max) is improved by the exercise carried out during cr, optimizing the physical condition and health-related quality of life (hrqol). the hrqol is considered a very important criterion used to evaluate the effectiveness of different treatments in patients with coronary disease, and is defined by subjective evaluation regarding the current activities of health care and health promotion; it indicates the personal perception in various aspects such as the recovery of the functional, labor, sexual and social capabilities of the patient, factors that have great importance in the evolution of the patient; this perception is considered the best indicator of quality of life, and has become a key concept for the decision making. in this study, we will evaluate the effects of a physical exercise program in the health-related quality of life of subjects following cabg or pci with normal and reduced left ventricular ejection fraction (lvef)

Eligibility criteria:
inclusion criteria: - cabg or post-pci subjects and agreed to participate by signing the informed consent form. exclusion criteria: * subjects with musculoskeletal limitations for physical exercise, untreated ventricular arrhythmias, with the presence of residual pericardial effusion, history of intermittent claudication or left ventricular ejection fraction \<30% measured by 2d-echocardiography

Keywords: left ventricular ejection fraction; quality of life
umbilical cord mesenchymal stem cells transplantation in the treatment of bronchopulmonary dysplasia

Conditions: Bronchopulmonary Dysplasia

Summary: to evaluate the safety and efficacy of human umbilical cord mesenchymal stem cells transplantation in patients with bronchopulmonary dysplasia

the purpose of this study is to evaluate the safety and effectiveness of human umbilical cord mesenchymal stem cells in 10 patients with bronchopulmonary dysplasia at vinmec international hospital, hanoi, vietnam

Eligibility criteria:
inclusion criteria: * the patient is diagnosis bronchopulmonary dysplasia (premature and depends on oxygen until 28 days old * gender: either sex * year old \< 6 months * weight ≥ 2 kg * agree to participate in the study. exclusion criteria: * severe congenital malformation. * other severe conditions (active pulmonary bleeding, evidence of active infections).

Keywords: bronchopulmonary dysplasia umbilical cord mesenchymal stem cells
evaluation of the occurrence of early thrombosis on central venous catheter by ultrasound in pediatric intensive care unit

Conditions: Central Venous Catheters

Summary: the objective of this study is to prospectively describe the incidence of early venous thrombosis secondary to the placement of a percutaneous central venous catheter, in a pediatric intensive care unit, by systematic ultrasound screening.

in pediatric resuscitation, the use of a percutaneous central venous catheter is essential. it allows to administer strong osmolarity intravenous drugs or prolonged duration treatment and to carry out blood samples. in the course of the placement of a central venous catheter, there is a risk of occurrence of early thrombosis between 20 and 45%, appearing mainly in the 4 first days. the occurrence is explained by the virchow triad: endothelial lesion (linked to the central venous catheter), venous stasis, hypercoagulability. ultrasonography is an imaging test that can be performed at the bedside, allowing the non-invasive collection of diagnostic elements of thrombosis (visible thrombus, non-compressibility of the vein, abolition of venous flow). performing ultrasound for thrombosis screening is essential because of a very low clinical expression of thrombosis, while the consequences are potentially severe, including infection, embolism, venous insufficiency and loss of venous access for children who will need several central venous catheters during their lifetime. despite the knowledge of certain risk factors (i.e. assisted ventilation, history of cancer, transfusions,...), there is actually no consensus for the systematic screening of venous thromboses on central venous catheters. systematic thromboprophylaxis is not recommended for central venous catheters (grade 1b). concerning the curative treatment of central venous catheter thrombosis, unfractionated heparin or low molecular weight heparin (grade 1b) is recommended. if the central venous catheter is no longer needed for the care, it can be removed after 3 to 5 days of anticoagulants (grade 2c). it can also be kept under cover of anticoagulant treatment if its use is essential (grade 2c). the objective of this study is to prospectively describe the incidence of early venous thrombosis secondary to the placement of a percutaneous central venous catheter, in a pediatric intensive care unit, by the systematic ultrasound screening.

Eligibility criteria:
inclusion criteria: - all children hospitalized in pediatric intensive care unit requiring the placement of a central venous catheter. exclusion criteria: * impossibility of delivering an information in order to obtain a non-opposition. * absence of acoustic window (dressings). * removal of the catheter before performing the ultrasound.

Keywords: percutaneous central venous catheter thrombosis children ultrasound scan