Kornimate/medical-research-clean huggingface dataset:
artificial intelligence + care coach intervention

Conditions: Dementia; Caregiver; Emergency Department; Artificial Intelligence; Care Transition

Summary: the purpose of this research study is to develop and test an artificial intelligence intervention for emergency department (ed) discharge care transitions experienced by caregivers of older adults with cognitive impairment.


Eligibility criteria:
inclusion criteria: * age ≥65 years with a diagnosis of dementia within the electronic health record or new cognitive impairment identified during an ed visit * be fluent in english or spanish * discharge after an ed visit * possession of a smart device (either a phone, tablet, or computer) that has internet access to utilize and interact with neuvicare ai services exclusion criteria: - evidence of delirium, by the 4-at screening tool
benefits of breast mri for predicting of histopathologic cell type of small breast cancer

Conditions: Invasive Breast Cancer

Summary: this study examines the additional benefits of magnetic resonance imaging (mri) with gadovist in early breast cancer with poor prognostic features.

dedicated contrast-enhanced magnetic resonance imaging (dce-mri)

Eligibility criteria:
inclusion criteria: * patients with invasive ductal carcinoma * patients undergoing dce-mri scan which are assessed according to bi-rads lexicon * breast cancer patients with pathological diagnosed invasive ductal carcinoma with hormonal receptor (er, pr and her-2) response * patients who have signed on informed consent form patients will undergo mri imaging and the physicians will practice according to practice guidelines. exclusion criteria: * patients under 18 years old or during pregnancy * patients with mri's contraindications e.g. patients with cardiac pacemaker or are allergic to mri contrast agent patients with unstable clinical abnormality and might get unexpected clinical treatment
surviving opioid overdose with naloxone education and resuscitation trial (sooner)

Conditions: Opioid Use; Opioid-Related Disorders; Opioid Withdrawal; Opioid Overdose; Education; Resusitation

Summary: among people at risk of opioid overdose and receiving care in an academic emergency department, family practice, opioid substitution clinic or general inpatient units, does brief opioid overdose resuscitation training and naloxone distribution reduce resuscitation failures in a simulated overdose even, in comparison with standard-of-care referral to a local oend program, within 14 days post-intervention? can an integrated participant recruitment and retention strategy recruit approximately 28 eligible participants within 4 weeks and maintain less than 50% attrition rates in the context of a randomized trial on point-of-care oend and simulated overdose resuscitation performance in family practice, emergency department, and addictions settings?


Eligibility criteria:
inclusion criteria: 1. adults ≥16 years of age, and 2. eligible for overdose education according to criteria adapted from the 2015 american heart association guidelines by meeting any one or more of the following criteria: 1. has a history of taking opioids at recognized 'high doses' (whether by prescription or otherwise, defined as \>100mg morphine equivalent per day); 2. has required emergency care for opioid overdose previously; 3. is enrolled in opioid agonist treatment programs, including methadone or buprenorphine maintenance programs, or stopped an opioid agonist treatment program in the last 6 months; 4. uses non-medical opioids, injects opioids, or acquires opioids from sources other than a pharmacy or healthcare setting; 5. has a history of non-medical opioid use who are being released from prison; 6. is receiving prescription opioid therapy with risk factors for adverse effects, including i. relevant comorbidities, ii. co-prescriptions of benzodiazepines or other sedatives, iii. concomitant ongoing alcohol use, iv. use of prescription opioids not as prescribed. 7. is likely to witness an opioid overdose, defined as anyone who lives with or is in frequent contact with others who use opioids, or who has previously witnessed an opioid overdose. exclusion criteria: 1. plan to move away from toronto during the study period 2. have no mode of contact or follow-up, 3. have a community do not resuscitate order, 4. have a terminal illness, end-of-life care, or illness likely to result in death within the study period, 5. are an active or previously practicing healthcare professional or professional first responder (e.g.: firefighter, police officer, lifeguard, industrial first responder), or 6. have insufficient english language skills to participate in the study.
sonographic features of cellulitis and failure of therapy

Conditions: Cellulitis

Summary: skin and soft tissue infections represent a tremendous burden to the health care community with over 11.6 million ambulatory patients presenting annually in 2003 and 14.2 million in 2005. a cochrane review of cellulitis found that there is limited data to support any specific antibiotic or even a specific length of antibiotic therapy, and that outpatient therapy for cellulitis is increasing. soft tissue ultrasound has been shown to have utility in differentiating cellulitis from abscess but its role in patients with cellulitis is not well developed. although speculative, the investigators hypothesize that sonographic features of cellulitis are associated with clinical improvement and successful therapy following antibiotics for patients with cellulitis.

the primary objective is to determine if changes in the sonographic features of cellulitis are associated with failure of therapy. patients with cellulitis treated in the ed with either intravenous or oral antibiotics will undergo imaging using a standardized ultrasound protocol. patients will be screened and enrolled in the ed at the umass memorial medical center. the study design is single center prospective observational trial involving adult patients with clinical signs of cellulitis requiring antibiotics but not admitted to the hospital. patients will be imaged upon initial presentation to the ed. patients discharged from the ed after the initial visit will return to the ed in 24 to 48 hours for a reassessment. patients kept in the ed under observational status will undergo an identical reassessment. clinical staff blinded to the ultrasound results will characterize patients as improving, no change or worsening based on progression of the erythema despite antibiotics or change in clinical status. researchers blinded to the clinical data will review the ultrasound images to quantify the extent of the sonographic evidence of cellulitis compared to the extent of the erythema by physical exam findings.

Eligibility criteria:
inclusion criteria: * 18 years or older symptoms of cellulitis (localized warmth, erythema, swelling or tenderness) exclusion criteria: admitted for inpatient antibiotics unable to consent septic appearing crepitus on exam animal bite soft tissue abscess osteomylitis cellulitis requiring surgical debridement

Keywords: cellulitis ultrasound
look at food and lose your fear - evaluation of a computerized attention training (cat) for anorexia nervosa patients

Conditions: Anorexia Nervosa

Summary: the purpose of this study is to test the therapeutic effects of a computerized attention training for patients with anorexia nervosa (an). the primary aim is to determine if a computerized attention training can modify attention towards food and ameliorate eating disorder symptoms and related difficulties, such as anxiety. the secondary aim is to explore underlying mechanisms that contribute to these improvements. the stability of potentially observed effects over a one-month period will also be determined.

recently, attention bias modification (abm) has successfully been applied in the field of anxiety disorders and emerging evidence suggests that attention bias modification can ameliorate attention bias for threatening stimuli. abm is based on the premise that if biased attention maintains disorder symptoms, a modification of the bias should reduce symptoms. the advantage of abm is that it operates implicitly, thereby offering a more indirect, less deliberate procedure. this requires less cognitive control compared to the effortful and explicit psychotherapeutic treatment of cognitive biases. as food-related fears and avoidance in an patients have been recognized as important anxiety-related symptoms, abm seems particularly suitable to treat food-related fears and avoidance, especially because an patients might be unaware of their avoidance strategy. the aim of this study is to test if food-related fears and food avoidance can be changed by experimentally modifying attention towards food in anorexia nervosa patients using an innovative computerized training paradigm (computerized attention training - cat) and to evaluate related change in symptoms. the investigators hypothesize that the active cat will change attentional processing of food cues (research aim 1), transfer to changes in food-related fears and food avoidance, and to improvements in an symptoms and weight in the short term (research aim 2) and longer term (research aim 3).

Eligibility criteria:
inclusion criteria: * bmi \< 18.5 5 kg/m2 * current diagnosis of an-restricting type, an-binge/purging type or eating disorder not otherwise specified (ednos) - anorexia type * fluent in english exclusion criteria: * currently taking a dose of any psychoactive medication that has not been stable for at least 14 days prior to participation in the study * currently meeting the diagnostic criteria of another major psychiatric disorder (e.g., major depressive disorder, substance dependence, schizophrenia or bipolar disorder) needing treatment in its own right * learning and developmental impairments * if the disorder is currently life threatening * if patients are currently suicidal * if patients are currently having extreme physiological complications or co-morbid alcohol and drug-abuse disorders

Keywords: eating disorders anorexia nervosa attention bias attention bias modification
urotensin ii in chronic kidney diseases and kidney transplants

Conditions: Chronic Renal Disease

Summary: the investigators are planning to study the serum level of urotensin ii in chronic kidney disease patients, kidney transplants, and healthy controls.

the investigators will determine the urotensin ii levels in chronic kidney disease patients, kidney transplants, and healthy controls.

Eligibility criteria:
inclusion criteria: * age more than 18 exclusion criteria: * inability to give a written consent

Keywords: urotensin ii,chronic renal disease
physiotherapy scoliosis specific exercise improves truncal shift in idiopathic scoliosis

Conditions: Scoliosis; Apical Deviation; Adolescent Idiopathic Scoliosis

Summary: introduction: truncal shift caused by scoliosis can be measured with a formetric scanner using the maximal thoracic apical deviation (mtad) measurement. it is a well-documented complaint with regards to body-image in patients with idiopathic scoliosis (is). furthermore, thoracic apical deviation is an important measure in pre-operative assessment and post-operative outcomes. objective: the aim of this retrospective cohort study was to determine the long-term effects of an intensive course of physiotherapy scoliosis specific exercise (psse) on mtad in patients with is. methods: consecutive is patients with a single right-sided thoracic curvature who completed an intensive 4-week course of psse were recruited. data was collected between april 2019 and december 2021. all patients were routinely scanned using a formetric scanner pre-, immediately post-, 12- and 24-months post-treatment. mtad, measured in millimetres, was documented. adults (\>17 years old) (group 1) and children (group 2) were analysed separately.


Eligibility criteria:
inclusion criteria: * patients who completed the group treatment program in its entirety. patients who have measurements obtained from all necessary time points. patient who have scoliosis and who have a primary thoracic curvature. exclusion criteria: * patient who did not complete treatment or all measurements obtained. patients who underwent surgery.
the role of serotonin in intensive care patients

Conditions: Sepsis; Septic Shock; Cardiac Arrest With Successful Resuscitation; Multiple Trauma

Summary: sepsis, cardiac arrest and multiple trauma are potentially life-threatening conditions and common reasons for intensive care unit (icu) admission. the aim of this study is to investigate the role of the signaling substance serotonin in blood in these conditions.


Eligibility criteria:
icu-patients inclusion criteria: * active treatment of sepsis, septic shock, cardiac arrest with rosc or severe multiple trauma. * age over 18 years * written consent from the patient or preliminary consent from the next of kin. * receiving mechanical ventilator treatment upon inclusion. * arterial and central venous cannulas present. exclusion criteria: * withdrawal of consent * serotonergic carcinoid syndrome, short bowel or other considerable comorbidity altering serotonin content in blood. * intoxication prior to icu admission. healthy controls inclusion criteria: * age over 18 years and signed written consent. * conformed to diet and activity restrictions. exclusion criteria: * any acute illness or injury * ongoing autoimmune, malignant, infectious, or other inflammatory disease. * severe psychiatric disease or drug abuse. * use of any medication except oral contraceptives last two weeks. * withdrawal of consent. icu controls inclusion criteria: * status epilepticus, encephalitis, stroke, or other localized neurological disease. * age over 18 years * written consent from the patient or preliminary consent from the next of kin. * receiving mechanical ventilator treatment upon inclusion. * arterial and central venous cannulas present. exclusion criteria: * withdrawal of consent * clinical signs of infection with focal symptoms or temperature over 38,0°c. * biochemical signs of infection or inflammation with leukocytes \> 11 x 10\^9/l, crp \> 15 mg/l, or pct \> 0,10 μg/l. * respiratory failure with pao2/fio2 ratio \< 40 kpa. * circulatory failure with map \< 60 or need for pressor treatment prior to sedation. * thrombocytopenia or thrombocytosis with platelets \ 400 x 10\^9/l. * serotonergic carcinoid syndrome, short bowel or other considerable comorbidity altering serotonin content in blood. * extracranial autoimmune or malignant disease. * severe psychiatric disease or drug abuse. * intoxication or physical trauma prior to icu admission.

Keywords: serotonin 5-hydroxytryptamine 5-ht 5-hydroxyindoleacetic acid 5-hiaa platelet poor plasma-serotonin ppp-serotonin
transcriptome sequencing analysis of whole blood from patients with trigeminal neuralgia

Conditions: Trigeminal Neuralgia; Blood; Plasma; Cerebrospinal Fluid

Summary: trigeminal neuralgia is a type of neuropathic pain that brings great physical and psychological pressure to patients. chronic pain can cause changes in the composition of central and peripheral body fluids, and these changes may be useful for the prediction and treatment of pain. in this study, the whole blood of patients with trigeminal neuralgia and non-chronic pain was collected, and transcriptome sequencing (rna-seq) was performed to determine the peripheral transcriptome changes of trigeminal neuralgia (tn) patients. and compare the expression of neuropeptide y (npy) in plasma and cerebrospinal fluid of tn and non-chronic pain patients.

trigeminal neuralgia is a kind of paroxysmal, knife-cutting, stubborn and severe pain in the facial distribution area of the trigeminal nerve caused by slight stimulation, which brings a great physical and psychological burden to the patient. chronic pain can cause changes in the composition of central and peripheral body fluids, and these changes are very useful for the prediction and treatment of pain. in this study, the whole blood of patients with trigeminal neuralgia and non-chronic pain was collected for transcriptome sequencing (rna-seq) sequencing. the results of transcriptome sequencing can derive the differentially expressed genes in the whole blood of tn patients and the pathways enriched by differentially expressed genes. at the same time, npy (neuropeptide y) plays an important role in head and face pain. we will also verify the difference in npy expression in the cerebrospinal fluid and plasma of tn and non-chronic pain patients, and the correlation between npy expression and pain.

Eligibility criteria:
inclusion criteria: 1. patients with primary trigeminal neuralgia receive trigeminal nerve microvascular decompression, and healthy people without a history of chronic pain or patients with facial nerve palsy without chronic pain receive facial nerve decompression as a control; 2. age from 30 to 60 years old 3. complete white blood cell count: 4.8\~11.0x109/l exclusion criteria: 1. patients with co-infection and tumor 2. patients with craniocerebral disease
probiotic use for recovery enhancement from long covid-19

Conditions: Post-Acute COVID-19 Syndrome

Summary: the goal of this clinical trial is to learn if probiotics can improve symptoms and quality of life in participants with long covid. the main questions it aims to answer are: 1. do probiotics reduce the number and severity of symptoms in those with long covid? 2. do probiotics improve physical and mental health quality of life in those with long covid? 3. do probiotics improve return to work and daily activities in those with long covid? researchers will compare probiotics to a placebo (a look-alike substance that contains no probiotics) to see if probiotics works to treat long covid. participants will take the study medication (placebo or probiotic) for 4 months. they will then cross-over (take the other medication) for an additional 4 months. participants will complete a survey at baseline, 4 months, and 8 months.


Eligibility criteria:
inclusion criteria: * age ≥18 years who report long covid with persistent symptoms at the time of study initiation exclusion criteria: * no longer have symptoms consistent with lc * are unable to take the study medication daily * are currently pregnant or planning to become pregnant over the course of the study * are currently breastfeeding * have been diagnosed with an immune-compromising condition * are currently taking immunosuppressants * do not speak english as a primary language * are regularly taking probiotics * are enrolled in another long covid study with an intervention

Keywords: long covid post-acute sequelae of covid
longitudinal population-based observational study of covid-19 in the uk population

Conditions: COVID-19

Summary: covidence uk is a population-based observational longitudinal study that has the following objectives: 1. to determine risk factors for incident covid-19 and for adverse outcomes of covid-19 in the uk population 2. to characterise the natural history of covid-19 in the uk population 3. to evaluate the impact of covid-19 on the physical and mental health of the uk population 4. to provide a resource from which to identify potential participants for future clinical trials, and to use data collected in covidence as comparison or control data for trial participants who have been randomised to receive one or more interventions.


Eligibility criteria:
inclusion criteria: * uk resident * age ≥16 years exclusion criteria: none
intacs for non ectatic with high cylinder

Conditions: Cornea

Summary: intra-corneal rings implantation for correcting high cylinder errors in non ectatic corneas


Eligibility criteria:
inclusion criteria: * non ectatic corneas with high cylinder error exclusion criteria: * corneal ectasia
a study to evaluate the efficacy and safety of subcutaneous sonelokimab compared with placebo in adult participants with moderate to severe hidradenitis suppurativa

Conditions: Hidradenitis Suppurativa

Summary: this is a study to evaluate the clinical efficacy and safety of sonelokimab administered subcutaneously compared with placebo in the treatment of adult participants with moderate to severe hidradenitis suppurativa. participants will be randomized 2:1 to either sonelokimab or matching placebo up to week 16.


Eligibility criteria:
inclusion criteria: 1. participants must be at least 18 years of age at the time of signing the informed consent. 2. participants who are diagnosed with hidradenitis suppurativa as determined by the investigator and have a history of signs and symptoms of hidradenitis suppurativa for at least 6 months before signing the informed consent. 3. participants who have had an inadequate response to appropriate systemic antibiotics for treatment of hidradenitis suppurativa (or demonstrated intolerance to, or had a contraindication to, systemic antibiotics for treatment of their hs), in the investigator's opinion. 4. participants who have a total an count of ≥5. 5. participants who have hs lesions present in ≥2 distinct anatomical areas, at least one of which must contain single or multiple fistulas (ie, be hurley stage ii or iii). exclusion criteria: 1. participants with a known hypersensitivity to sonelokimab or any of its excipients. 2. participants with any other active skin disease or condition that may, in the opinion of the investigator, interfere with the assessment of hs. 3. participants with underlying conditions that, in the opinion of the investigator, potentially places the participant at unacceptable risk. 4. participants with current severe or uncontrolled disease(s) that put(s) the participant at increased risk in the investigator's opinion, would preclude the participant from adhering to the protocol or completing the study per protocol. 5. participants with any other known autoimmune disease or any medical condition that in the opinion of the investigator would interfere with an accurate assessment of clinical symptoms of hs. 6. participants with a gastrointestinal condition including inflammatory bowel disease or diagnosis of ulcerative colitis or crohn's disease.

Keywords: hidradenitis suppurativa hidradenitis sweat gland diseases skin diseases skin diseases, bacterial suppuration anti-inflammatory agents sonelokimab nanobody apocrine gland disease