Kornimate/medical-research-clean huggingface dataset:
awake prone positioning to reduce invasive ventilation in covid-19 induced acute respiratory failure

Conditions: ARDS, Human; Mechanical Ventilation Complication; COVID19

Summary: prone positioning (pp) is an effective first-line intervention to treat moderate-severe acute respiratory distress syndrome (ards) patients receiving invasive mechanical ventilation, as it improves gas exchanges and lowers mortality.the use of pp in awake self-ventilating patients with (e.g. covid-19 induced) ards could improve gas exchange and reduce the need for invasive mechanical ventilation, but has not been studied outside of case series.the investigators will conduct a randomized controlled study of patients with covid-19 induced respiratory failure to determine if prone positioning reduces the need for mechanical ventilation compared to standard management.

prone positioning (pp) is an adjunctive therapy used that has been proven to save lives in sedated patients with confirmed moderate-severe acute respiratory distress syndrome (ards) receiving invasive mechanical ventilation (mv). pp involves placing patients in the prone, i.e. face down position for time periods of up to 16 hours per day. pp promotes lung homogeneity, improves gas exchange and respiratory mechanics permitting reduction of ventilation intensity, and reducing ventilator-induced lung injury (vili). maintaining self-ventilation is associated with increased aeration of dependent lung regions, less need for sedation, improved cardiac filling and removes the risk of vili, and so is an important therapeutic goal in hypoxic patients. the use of pp in awake self-ventilating patients with covid-19 induced acute hypoxic respiratory failure (ahrf) and/or ards could improve gas exchange and reduce the need for invasive mv, but has not been studied outside of case series. however, an increase in oxygenation does not necessarily reduce the risk of invasive mv. pp has significant attached risks such as causing pressure sores in patients, pp is uncomfortable for some patients, it increases nursing workload, and if ineffective could hinder the delivery of other (effective) medical care. hence there is a need to determine if pp of awake patients is effective in reducing the need for invasive mv. this multi-centre, open label, randomized controlled study of covid-19 induced ahrf/ards will determine if pp reduces the need for mechanical ventilation.

Eligibility criteria:
inclusion criteria: * suspected or confirmed covid19 infection * bilateral infiltrates on cxr * spo2 \<94% on fio2 40% by either venturi facemask or high flow nasal cannula * rr \<40 * written informed consent exclusion criteria: * age \<18 * uncooperative or likely to be unable to lie on abdomen for 16 hours * receiving comfort care only * multi-organ failure * rr\>40 * contraindication to pp (e.g. vomiting, abdominal wound, unstable pelvic/spinal lesions, pregnancy \>20/40 gestation, severe brain injury).
study of the effect of rifampicin on the pharmacokinetics (pk) of multiple doses of cediranib in patients with solid tumours

Conditions: Solid Tumors

Summary: phase i, open study to assess the effect of rifampicin, a marketed drug, on how the body handles the experimental drug cediranib in patients with advanced cancer.


Eligibility criteria:
inclusion criteria: * written informed consent * prostate cancer), which is refractory to standard therapies or for which no standard therapy exists. * estimated life expectancy of at least 8 weeks * who performance status (ps) 0-2. exclusion criteria: * unstable brain/meningeal metastases * biochemistry/haematology results outside of required ranges * history of significant gi impairment * inadequate bone marrow reserve

Keywords: advanced cancer metastatic rifampicin pharmacokinetics phase i advanced solid tumours
characterization of early markers of choroidal neovascularization

Conditions: Age-related Macular Degeneration

Summary: to this study and identify the sequence of alterations occurring in the chorioretinal interface during progression of amd from "dry" amd to sight-threatening chorioretinal neovascularization (cnv).

the primary statistical objective of this study is to identify the sequence of alterations occurring in the chorioretinal interface during progression of amd from risk "dry" amd to sight-threatening chorioretinal neovascularization (cnv) (wet amd). different imaging methods will be used simultaneously and at regular intervals in order to characterize markers or predictors of conversion to sight-threatening cnv will be: cnv (classic or occult) or position of cnv within 2500 µm (\~1.7 disc diameters) of the foveal center, as evidenced by fluorescein angiography. this is an institutional, prospective, observation study to be performed in fellow eyes of patients with evidence of "wet" amd in other eye. therefore, patients will have evidence of exudative ("wet") amd in one eye ( the non-study eye) and non-exudative ("dry") amd in the fellow eye (the study eye) that is at risk for progressive to exudation "wet" cnv. patients will exit the study at the time of developing sight-threatening cnv in the study eye and will be treated at the discretion of the physician.

Eligibility criteria:
inclusion criteria: * written informed consent * age over 50 years * any race and any sex * clinical diagnosis of exudative am;d in one eye (non-stud eye) and the presence of the following characteristics in the second eye (study eye, eye to be treated): * at least 5 or more intermediate (\> 63 µm) or larger soft drusen and/or confluent drusen within 3000 µm of the fovea center * hyperpigmentation exclusion criteria: * history of medical condition that would preclude scheduled study visits * history of ophthalmic disease in the study eye other than amd * clinical signs of myopic retinopathy, or refraction higher than -8 diopter power. * intraocular surgery in the study eye within 60 days prior enrollement * evidence of past or present cnv in the study eye

Keywords: amd
healthy kids i-pal

Conditions: Childhood Obesity

Summary: up to 30 parent/child dyads will be recruited to participate in an m-health intervention (delivered over smartphone, ipad/tablet, or desktop/laptop) to promote healthy behaviors and healthy weight among children and their parents.


Eligibility criteria:
inclusion criteria for child: * have at least one participating parent * be physically capable of exercise * be free of diseases that affect metabolism, body weight, and food intake, including type 1 or type 2 diabetes, hiv/aids, and cancer inclusion criteria for parent: * have a smart phone * be willing to use the smartphone for the mhealth intervention exclusion criteria for child: * significant cardiovascular disease or disorders via self-report from parent * other significant medical problems that would prevent them from engaging in regular physical activity.
evaluating impact of near infrared autofluorescence (niraf) detection for identifying parathyroid glands during parathyroidectomy

Conditions: Parathyroid Adenoma; Parathyroid Neoplasms; Parathyroid Cancer; Hypercalcemia; Primary Hyperparathyroidism

Summary: this study will see if the use of near infrared autofluorescence (niraf) detection with an fda-cleared device 'parathyroid eye (pteye)' for identifying parathyroid glands (pgs) during parathyroidectomy (ptx) procedures is better than a surgeon's detection alone. it compares risk-benefits and outcomes in ptx patients where niraf detection with pteye for parathyroid identification is either used or not used.


Eligibility criteria:
inclusion criteria: * primary hyperparathyroidism who will be undergoing parathyroid surgery * persistent primary hyperparathyroidism after having undergone a failed prior parathyroid surgery who will be undergoing repeat parathyroid surgery exclusion criteria: * pregnant women (those patients who could potentially will receive preoperative pregnancy testing, as is standard before general anesthesia. any patients with positive pregnancy test results will not be included in the study.) * patients with concurrent parathyroid and thyroid disease that require total thyroidectomy * patients with secondary or tertiary hyperparathyroidism

Keywords: parathyroidectomy intraoperative parathyroid identification near infrared autofluorescence persistent hyperparathyroidism persistent hypercalcemia failed parathyroidectomy repeat parathyroidectomy
post-marketing study of gabapentin enacarbil to evaluate the effect in restless leg syndrome (rls) patients with moderate renal impairment

Conditions: Restless Legs Syndrome (RLS)

Summary: to evaluate the safety, efficacy and pharmacokinetics of gabapentin enacarbil in moderate to severe primary rls patients with moderate renal impairment and to confirm dosage and administration in such population.

this study is a multicenter, non-blinded, non-comparative study. patients who meet the eligible criteria will undergo one week observation period followed by four week treatment period. in treatment period, patients will receive gabapentin enacarbil orally one daily after dinner. after the four-week treatment period with gabapentin enacarbil, a one-week post-observation period will be undertaken.

Eligibility criteria:
inclusion criteria: * patients who have been diagnosed with restless legs syndrome (rls) according to the international rls study group diagnostic criteria * patients whose score is 15 or greater on the international rls (irls) rating scale on the first day of the pre-observation period. * patients whose creatinine clearance level at the first day of pre-observation period is ≥30 ml/min to \<60ml/min estimated by cockcroft-gaul t equation * patients who provide written consent exclusion criteria: * patients with sleep disorder such as sleep apnea syndrome, which affects the rls evaluation * patients with history of augmentation and treatment rebound of rls symptoms when using dopamine agonis * patients with neuropathy and movement disorder (diabetic neuropathy, parkinson's disease, multiple sclerosis, dyskinesia, rheumatoid arthritis etc) * patients with uncontrolled diabetes \[hba1c\>7.5% (ngsp value), in the past six months\], iron deficiency anemia, or drug administration of hypnotic sedatives. * patients who attempted suicide within six months prior to the consent obtained, or who have been diagnosed as a suicide risk by investigator or sub-investigator * patients with moderate or severe depression * patients with alcohol dependence or drug intoxication or who have a history of abuse or drug dependence in the past one year * patients whose job is shift work, professional driver, or engaging in hazardous activities such as operating machinery * patients with history of hypersensitivity to gabapentin * patients who have experience to participate in other post-marketing clinical studies or clinical trials within 12 weeks prior to the start of pre-observation * others: patients who are concluded to be ineligible by an investigator or sub-investigator as ineligible

Keywords: gabapentin restless legs syndrome (rls)
the influence of autophagy on fatty liver

Conditions: Non-alcoholic Fatty Liver Disease; Obesity

Summary: non-alcoholic fatty liver disease (nafld) is one of the most common causes of chronic liver disease worldwide. it is not known why only some obese subjects develop nafld. in recent years, a growing body of evidence showed a crucial role of autophagy in in the regulation of liver fat storage. the purpose of this study is to determine whether autophagy pathway-related genetic polymorphisms affect nafld.

the investigators will perform a prospective comparison of the genotype distribution of autophagy pathway-related genetic polymorphisms between those with and without nafld in a cohort of obese children and adolescents. \[subjects\] obesity is defined as the bmi value \> 95 percentile by different age- and gender groups according to the standards of the department of health in taiwan. \[data collection\] the following data were obtained for each subject: age, gender, bmi, waist and hip circumference. the investigators will measure total serum bilirubin, alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase fasting glucose, triglyceride, total cholesterol, and high-density lipoprotein cholesterol, insulin, glucose, and adiponectin. \[liver ultrasonography\] all participants will receive an ultrasonographic study of the liver. nafld is defined as the presence of an ultrasonographic pattern consistent with the following criteria: liver-kidney echo discrepancy, attenuated echo penetration and visibility of diaphragm, and obscure hepatic vessel structures. \[genotyping\] genomic dna will be extracted from 3 cc venous blood from each participant. after extraction, the genomic dna will be immediately stored at -80°c. the taqman genotyping assays will be performed for selected snps genotyping on abi 7300 real-time pcr system (applied biosystems). \[sample size\] sample size was estimated by epi infotm 7 (cdc, usa) program. because there was no previous data regarding to the effect of autophagy related gene on nafld, the investigators estimate the odds ratio to vary between 60-80%. the investigators used a confidence level of 95%, power of 80%, the ratio of controls to nafld cases of 25%, percent of controls exposed of 25-35%, the samples size required would be a total of 291-872 subjects.

Eligibility criteria:
inclusion criteria: * age 6-18 years old * obesity definition: bmi \> 95% according to the age- and gender-specific standard by national health institute in taiwan * willing to give written informed consent exclusion criteria: * alcohol consumption * chronic liver diseases, including hepatitis b, hepatitis c, wilson disease and autoimmune hepatitis * major systemic diseases, including cardiopulmonary disease, renal failure, cancer, and psychotic disorder

Keywords: autophagy children polymorphism
intraperitoneal mesh with 3cm overlap versus a rives-stoppa repair with a 6cm overlap in hernia umbilicalis

Conditions: Hernia, Umbilical

Summary: to study the advantages and disadvantages of a ventralex prothesis versus light weight vypro ii prothesis in patients with a hernia umbilicalis.


Eligibility criteria:
inclusion criteria: * symptomatic hernia umbilicalis * \> 18 years old exclusion criteria: -

Keywords: hernia umbilicalis
value of pleural lavage cytology in resectable esophageal carcinoma eastern cooperative thoracic oncology projects 2005, ectop-2005)

Conditions: Esophageal Cancer

Summary: disease recurrence and metastasis are common after curative treatment for patients with esophageal cancer. thus, it is important to identify the risk factors to predict disease recurrence and metastasis. pleural lavage cytology (plc) is reported to be associated with disease recurrence and patient survival in lung cancer, but the value is unclear in esophageal cancer. the aim of this study is to evaluate the value of plc in esophageal cancer patient in terms of frequencies, association with patient survival, and efficacy of postoperative treatment.

pleural lavage cytology will be performed before esophageal resection, and after resection, respectively. frequency of positive pleural lavage cytology will be determined, and the value of pleural lavage cytology for patients with resectable esophageal cancer will be studied.

Eligibility criteria:
inclusion criteria: * esophageal cancer with histological confirmation before treatment. * resectable esophageal cancer with clinical t1-4a/n0-3/m0 staging * potential r0 resection * no history of other malignancies exclusion criteria: * severe major organ dysfunction (american society of anesthesiologisits score \>3 ) * patients underwent esd or emr * pleural lavage is unavailable due to adhesions

Keywords: squamous cell carcinoma esophagectomy pleural lavage
administration of subcutaneous teicoplanin in the treatment of osteoarticular infections: tolerance study

Conditions: Osteoarticular Infection

Summary: this is a biomedical research, prospective, mono centric, tolerance study of the administration of subcutaneous teicoplanin in the treatment of osteoarticular infections.


Eligibility criteria:
inclusion criteria: * patient over 18 years * inpatient orthopedic surgery * achieved a bone and joint infection documented gram + (staphylococci golden coagulase-negative staphylococci, enterococci, streptococci) * bacteria resistant to lincosamides, quinolones and rifampicin * bacteria susceptible to teicoplanin (mic ≤ 4 mg / l) * balanced patient teicoplanin administered intravenously (2 successive doses between 30 and 40 mg / ml) exclusion criteria: * patient not affiliated to the social security * pregnant and lactating women * known hypersensitivity to teicoplanin (rash, ...) * patients with a central catheter or an implantable chamber * patient hemodialysis * patient has another participant biomedical research on a drug to prevent drug interactions * patient minor * patient major protected (protection of the court, wardship, trusteeship) * patient admitted for emergency or incapable of consent

Keywords: subcutaneous teicoplanin osteoarticular infections tolerance teicoplanin
safety and efficacy study of intentional delivery in women with preterm and prelabour rupture of the membranes

Conditions: Fetal Membranes, Premature Rupture

Summary: two-year multicentre randomized controlled parallel trial to compare intentional delivery and conservative management in pregnant women with preterm and prelabour rupture of membranes between 32 and 35 weeks. the purpose of this study is to determine whether intentional delivery of women with pprom between 32 and 35 week's gestation can decrease the overall neonatal morbidity associated with pprom-related complications without increasing the morbidity associated with a shortened pregnancy.


Eligibility criteria:
inclusion criteria: * women with recent pprom between 31 weeks + 6 days and 35 weeks + 6 days (estimated gestational age based on an ultrasound examination before 18 weeks of gestation), not in labour 24 hours after admission\*, will be considered eligible for the study provided the following inclusion criteria (\*for patients transferred from a remote level 2 centre to one of the participating sites within the first hours after pprom, the onset of the 24-hour screening period will be the time of admission in the centre of origin. patients in group a will be given their first dose of antenatal steroids before the transfer) * single and otherwise uncomplicated pregnancy * recent history (less than 48 hours) of leaking with the two followings within 24 hours after primary medical assessment: documentation of fluid from the vagina and positive fern test, or positive nitrazine test, or positive actim prom test * antenatal steroids course initiated after the rupture for women with pprom between 31 + 6 and 33 + 6 weeks * normal fetal heart rate trace using an external ultrasound transducer * written informed consent obtained before inclusion and randomization exclusion criteria: * multiple pregnancy * hiv positive mother * active hsv cervical lesions * major fetal anomaly on ultrasound examination performed after admission * intrauterine growth restriction estimated on ultrasound below the 5th percentile or preeclampsia * placenta abruption present at the time of the diagnosis of pprom or occurring within the first 24 hours after rupture * clinical chorioamnionitis existing before or at the time of the diagnosis of pprom or developing within the first 24 hours after rupture * non-reassuring fetal testing present at the time of the diagnosis of pprom or occurring within the first 24 hours after the rupture. it implies that expected criteria for standard fetal assessment parameters have not been met, including the non-stress test and the biophysical profile score. this will be diagnosed at the discretion of the attending physician. * more generally, any maternal or fetal reason for an immediate delivery, either existing at admission or occurring within the 24 hours after admission. * mother refusal or inability to provide consent

Keywords: premature or preterm birth chorioamnionitis neonatal sepsis labour cesarean section delivery length of stay pregnancy
intrabone cord blood transplantation

Conditions: Hematological Malignancies

Summary: the purpose of this study is to evaluate the viability of intrabone administration of umbilical cord blood as allogenic transplantation for the treatment of hematologic malignancies.


Eligibility criteria:
inclusion criteria: * hematological malignancies * indication of allogenic transplantation * no suitable donor (related/unrelated) * no suitable cord blood unit with enough cellularity for standard transplant * written informed consent exclusion criteria: * ecog \> 2 * co-morbidities * hiv positive serology * pregnancy or breastfeeding * psychiatric illness
extension block technique versus splinting in mallet finger fracture.

Conditions: Mallet Finger

Summary: mallet finger is an avulsion of the extensor tendon at its insertion on the base of the distal phalanx, with or without fracture. treatment af mallet finger fractures involving more than 1/3 of the articulating surface is controversial. there are to our knowledge no randomized controlled trials comparing splinting and surgical treatment with extension block technique. the aim of this study is to compare splinting and surgical extension block fixation of mallet finger fractures in a randomized controlled trial.our hypothesis is that conservative treatment with splinting is comparable to surgical treatment concerning functional outcome, and may even reduce the complication rates. the original protocol was designed to include participants with non-subluxated and subluxated mallet finger fractures. however this study only included participants with non-subluxated fingers.


Eligibility criteria:
inclusion criteria: * age \>18 years * mallet finger fractures with a \>1mm displaced fragment involving one-third or more of the articular surface and/ or subluxation of the distal phalanges. * fractures with a delay of \< 2 weeks. * with reference to wehbé and schneider's established classification, fractures type ib and ic are included. exclusion criteria: * open injuries * mallet finger fracture of the thumb * co-existing rheumatologic illness in the fingers * no-compliance patient
the therapeutic time window of mannitol during craniotomy for optimal brain relaxation in patients with supratentorial tumours

Conditions: Supratentorial Tumors

Summary: although mannitol is used for brain relaxation during neurosurgery and in the treatment of raised intracranial pressure; there is not a consensus on its safe, effective dose and the duration of its administration. this study aimed to compare the effects of the mannitol in different use times, on the brain relaxation, electrolyte, lactate levels of the blood, peroperative fluid balance and the volume of the urine in supratentorial mass resection surgeries.


Eligibility criteria:
inclusion criteria: * intracranial shift \>3mm * scheduled for supratentorial mass resection under elective conditions exclusion criteria: * decompensated heart failure * kidney insufficiency * diabetes insipidus, * electrolyte imbalance and * who are unconscious

Keywords: brain relaxation mannitol supratentorial tumours