Kornimate/medical-research-clean huggingface dataset:
dm device disruption survey

Conditions: Diabetes Mellitus

Summary: rationale: continuous glucose monitoring (cgm) and insulin pump therapy (csii) have increased in utilization in the treatment of both type 1 and type 2 diabetes mellitus. both types of devices are worn externally, with either a catheter or filament introduced into the subcutaneous space. removal of these devices interrupts glucose monitoring or insulin delivery or both, which may have an adverse impact on patients' glucose control. few studies have investigated the logistical and technical challenges that patients face when their insulin pump device or continuous glucose monitor (cgm) is interrupted. intervention: we will conduct a patient survey which seeks to identify and quantify the number of times insulin pump therapy or continuous glucose monitor has been disrupted, for what reason, how it was resolved and whether diabetes care had been adversely affected. objective: to determine the frequency and intensity of adverse health outcomes resulting from mandatory removal of cgm on insulin pump devices in healthcare or other settings. study population: patients treated at washington university outpatient clinics or barnes jewish hospital between august 1, 2021- december 1, 2021. the study will include outpatients with diabetes mellitus who routinely utilize either cgm or insulin pump therapy or both. the target number of patients for the study will be 600, equally distributed between inpatients and outpatients, and with at least 100 having type 1 diabetes. study methodology: after providing consent, patients will complete an electronic questionnaire. demographic information and diabetes history will be extracted from the patients' medical records. study endpoints: we will determine the incidence of disruptions to insulin pump therapy or continuous glucose monitoring in patients with diabetes mellitus as a result of hospitalization or medical test over a 1 year time period. we will also determine adverse health outcomes that resulted from device disruptions.


Eligibility criteria:
inclusion criteria female and male patients 18 years or older who meet all of the following criteria: * patients treated at washington university outpatient clinics or barnes jewish hospital. * patients with type 1 or type 2 diabetes mellitus who utilize cgm and/or insulin pump therapy. * patients who were able to read english. exclusion criteria * patients who have not used a relevant device in the past 30 days * patients unwilling to or unable to provide consent or complete the questionnaire.
effects of steroid injection with percutaneous needle aponeurotomy in dupuytren's contracture

Conditions: Dupuytren's Contracture

Summary: background: dupuytren's contracture is a common hand problem that causes certain fingers to bend towards the palm. patients with this condition cannot perform daily activities and many are unable to work. it is usually treated by an operation to straighten the fingers followed by therapy if the angle that the fingers are bent at is large enough. however, no treatment has been able to completely prevent the angle from persisting. objective: this study is designed to examine whether or not the use of a drug in combination with surgery will improve the angle at which the fingers are bent more than surgery alone. hypothesis: subjects who receive triamcinolone acetonide will have straighter fingers compared with subjects who only have the operation and no triamcinolone acetonide at both 3 months and 6 months after the operation. methods: eligible patients interested in having the operation to treat dupuytren's contracture will be asked if they would like to join the study. subjects will be randomly placed into one of two groups: the steroid injection group or the control group. subjects will have a pre-operative visit, the surgery, and follow-ups at 6 weeks, 3 months and 6 months. all subjects will have the operation, but only those in the steroid injection group will receive an injection of the drug. during the 6 week and 3 month follow-ups, subjects in the steroid injection group may receive another injection if their fingers are still bent. angles are measured at the pre-operative visit and at 3 and 6 months. the change in angle from before to after and any differences in the groups, in time points and interactions between the two will be analyzed.


Eligibility criteria:
inclusion criteria: * over the age of 18. * literate in the english language. * diagnosed by the pi with dupuytren's contracture with an angle of contracture of 20° or greater. * candidates for percutaneous needle aponeurotomy. * first surgery on the affected digit. exclusion criteria: * allergy or sensitivity to triamcinolone acetonide or any of the non-medicinal components in the suspension. * patient is not a candidate for steroid injection for other medical reasons, which will be determined by the pi.
effect of laser treatment on capillary malformations

Conditions: Capillary Malformation; Port Wine Stain

Summary: in this research study investigators want to learn more about capillary malformations which are also known as port wine stains. investigators are asking children with capillary malformations (port wine stains) to be in the research, because investigators do not have a good idea of what to expect from the current treatments of these malformations. these malformations are treated with laser as clinically indicated and there are no standardized methods to assess improvement.

capillary malformations, specifically port wine stains, occur in one of every 12,000 live births (0.3% of newborns) with 90% on the face or neck. pulsed dye laser therapy targeted at hemoglobin (i.e., 585 nm ± 5 nm) is commonly used to lessen the visual coloration and increase skin lightness. presently, the outcomes of laser treatment are difficult to predict, in part due to the difficulty in quantifying the tissue changes with visual inspection methods. quantitative skin imaging methods are currently being applied to measure the features and response to treatment for infantile hemangiomas. the current study proposes to apply these methods in the treatment of capillary malformations, e.g., port wine stains. the purpose is to determine (1) the effects of laser treatment on capillary malformations (using quantitative skin imaging methods and standard clinical assessment and (2) the relationships between the imaging outcomes immediately after treatment and after healing. in the within-subject design we aim to measure color, temperature, blood concentration and tissue mechanical properties for the capillary malformation relative to an un-involved site at baseline (prior to treatment), immediately following laser surgery and over time. imaging outputs will be compared to the standard clinical evaluation in up to 100 patients from the hemangioma and vascular malformation center (hvmc) at regular intervals to determine changes over time. skin sites will be imaged for color (size, erythema, blue color, lightness, excess erythema, uniformity), thermography, blood concentration and tissue mechanical properties (e.g., elasticity). skin characteristics will be examined at baseline, prior to surgery, immediately following laser treatment, just prior to discharge and at 2 and 4-6 weeks following treatment. for subjects receiving multiple laser treatments, the procedures will be repeated after each surgery. enrollment will occur over 2 years. patients will be evaluated for a period of up to 6 months following the last surgery. we expect the research to provide objective measures to clarify the effectiveness of laser treatment and permit effective measurement of tumor response for therapeutic protocols.

Eligibility criteria:
inclusion criteria: * age 0-17 * diagnosis of a capillary malformation * scheduled to undergo laser treatment of the capillary malformation * able to tolerate imaging procedures exclusion criteria: * not scheduled to undergo laser treatment for capillary malformation * other vascular anomaly * not able to tolerate imaging procedures
optimal dose of omeprazole after endoscopic treatment of bleeding peptic ulcers

Conditions: Bleeding Peptic Ulcers Disease

Summary: bleeding peptic ulcers are one of the major causes of morbidity and mortality for hospital emergency admissions.the initial treatment is endoscopic therapy followed by intravenous omeprazole. however the optimal dosage of omeprazole is not known. we conducted this study to find out the optimal dosage in such clinical scenario.

introduction peptic ulcer bleeding (pub) is a common and life threatening condition. intravenous infusion of high dose omeprazole (80mg as bolus followed by 8 mg/hr for 72 hours ie 652 mg/72 hrs) after endoscopic therapy resulted in greater reductions of re-bleeding than did placebo. thus the above regime became our departmental protocol. however, there is some evidence that both high dose and a regular dose of omeprazole (40mg once a day followed by a saline infusion ie 120mg/72 hrs) would be equally effective. we calculated that high dose regimen is about s$ 500 more expensive. the aim of our study is to determine the equivalence of both regimes in preventing re-bleeding rate (primary end-point), surgery and mortality in pub patients. study design this is a single institution prospective randomized double-blind study. all patient with pub (forrest classification i, iia and iib: spurting or oozing bleeding, visible vessels and clot) had endoscopic treatments (adrenaline injection and/or heater probe). after successful endoscopic hemostasis, patients are randomized to receive a high or regular dose of omeprazole infusion. after 72 hours, both groups of patients are given oral omeprazole 40mg daily for 4 weeks. all patients are evaluated at the clinic at the end of 4 weeks. the primary end-point is rebleeding. other secondary endpoints measured are surgery, duration of hospital stay and death.

Eligibility criteria:
inclusion criteria: 1. above 21 year old 2. ogd done within 48 hrs of admission 3. no recent upper git surgery past one month 4. forrest type i, iia \& iib ulcer (type ia: spurting, ib:oozing, iia: visible vessel, iib: clot) 5. non-malignant ulcer 6. informed consent taken exclusion criteria: 1. impaired hepatic function 2. pregnancy 3. lactation 4. concomitant medication (warfarin, diazepam, phenytoin, chlarithromycin, cimetidine and digoxin) 5. underlying malignancy

Keywords: rebleeding after endoscopic therapy
respiratory physiotherapy in severe covid-19 patients

Conditions: COVID-19

Summary: covid-19 is an infectious disease caused by sars-cov2 virus. covid-19 patients can develop a severe disease that can lead to hypoxic respiratory failure and acute respiratory distress syndrome (ards). severe patients can require access to intensive care unit (icu). early rehabilitation is known to be effective in critically ill patients and in ards. the role of respiratory physiotherapy in critical covid-19 patients is still unclear. the aim of this study is to describe the bundle and the timing of respiratory physiotherapy used with severe covid-19 patients from icu to hospital discharge. functional condition of patients at discharge will be assessed and described.

covid-19 is an infectious disease caused by sars-cov2 virus, that first appeared in china in 2019 and in italy in february 2020. approximately 80% of people infected with covid-19 have mild to moderate disease with few symptoms, while more than 10% develop a severe disease that can lead to hypoxic respiratory failure and acute respiratory distress syndrome (ards). severe patients can require access to intensive care unit (icu) needing invasive mechanical ventilation (imv) and hospitalization for a long period. early rehabilitation is known to be effective in critically ill patients and in ards, to reduce functional impairment due to the prolonged stay in icu. many works demonstrated that early rehabilitation programs in icu correlated with faster recovery and discharge at home of ards patients and better outcomes in the walking test at discharge from the hospital. due to the recent development of covid-19, few data and guidelines to menage severe covid-19 patients are available and the role of respiratory physiotherapy is still unclear. the aim of this study is to describe the bundle and the timing of respiratory physiotherapy used with severe covid-19 patients from icu to hospital discharge. functional condition of patients at discharge will be assessed and described.

Eligibility criteria:
inclusion criteria: * having laboratory confirmed covid-19 pneumonia * developed hypoxemic acute respiratory failure (harf) requiring access to icu * treated by respiratory physiotherapists during the hospitalization period exclusion criteria: * previously documented neurological or neuromuscular diseases * passed over 1 month in bed before covid-19 diagnosis * documented cognitive impairment (mini mental state examination \<24)

Keywords: icu respiratory physiotherapy early rehabilitation
the effect of mint flavored chewing gum on hyperemesis gravidarum nausea vomiting severity, coping with stress and anxiety level in pregnants with hyperemesis gravidarum

Conditions: Hyperemesis Gravidarum

Summary: in the research planned as a randomized controlled study, the experimental groups will be administered routine hyperemesis gravidarum (hg) treatment as well as chewing mint-flavored gum, while the control group will only receive routine hg treatment and no intervention will be performed. this study aims to contribute to the literature by investigating the effect of chewing mint-flavored gum on the severity of nausea and vomiting, coping with stress, and anxiety levels due to hyperemesis gravidarum in pregnant women.

the data of the research will be collected after the necessary institutional permission and ethics committee approval have been obtained. women who meet the inclusion criteria for the study will be informed about the method to be followed in the research. those who want to participate in the research will read and sign the volunteer information form. 1. intervention group in data collection, pregnant women will sign an informed consent form before the application. personal information form, vas scale, puqe scale, stress coping styles scale and state anxiety scale will be filled out. in addition to the routine treatment plan, the application will begin at least 4 hours after the antiemetic application (gökbulut, 2021). the application will continue by chewing mint-flavored gum twice a day for at least 15 minutes for 3 days. the vas scale will be filled after the morning chewing application, and the vas scale, puqe scale, stress coping styles scale and state anxiety scale will be filled in after the evening application. the forms of patients discharged during this period will be filled in via phone. 2. control group in data collection, pregnant women will sign an informed consent form before the application. at least 4 hours after the antiemetic application (gökbulut, 2021), the personal information form, vas scale, puqe scale and stress coping styles scale and state anxiety scale will be filled out. routine treatment and nursing care will be applied to the control group, and no intervention will be performed. 1. after the forms are applied, the forms will continue to be filled for 3 days: vas scale in the morning, vas scale in the evening, puqe scale, stress coping styles scale and state anxiety scale. the forms of discharged patients will be filled in via phone.

Eligibility criteria:
inclusion criteria: * pregnant women aged 18 and over * at least primary school graduate * the one who is married * pregnant women who are younger than 16 weeks of gestation and diagnosed with hyperemesis * those who agreed to participate in the study exclusion criteria: * those with a history of chronic disease * having a health problem that may cause nausea and vomiting in the current pregnancy * those who are allergic to mint

Keywords: hyperemesis gravidarum chewing gum nausea and vomiting mint
goal-oriented intervention in parkinson's disease

Conditions: Parkinson's Disease

Summary: upper-limb disorders in patients with parkinson's disease include decreased speed and amplitude of movements, difficulty in sequential tasks, and disrupted execution of fine manipulative hand activities.the aim of the study was to evaluate the effects of home-based goal-oriented upper limb intervention in patients with parkinson's disease.

parkinson's disease is a neurodegenerative neurological disorders involving progressive impairment in motor, mood and cognitive functions. movement disorders have a negative impact on individual's ability to perform well-learned motor skills. these include akinesia, bradykinesia, rigidity and tremor at rest. a goal-planning process should be useful to ensure that patients agree on the goals of rehabilitation. thus, the purpose of the study was to evaluate the effects of home-based goal-oriented upper limb intervention in patients with parkinson's disease.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of parkinson's disease. * stage ii-iii of disease progression as defined by the hoehn and yahr scale. * upper limbs impairment exclusion criteria: * clinical signs of dementia or psychiatric disturbance. * comprehension deficits that prevented them from following verbal commands. * visual or acoustic limitations. * a neurologic condition other than parkinson's disease. * musculoskeletal disorders and/or if they had previous trauma or fracture of upper extremity.

Keywords: upper limbs physiotherapy
the effects of protein supplementation in females and males following acute eccentric exercise

Conditions: Muscle Damage

Summary: examine the impact of the protein supplements leucine, hmb and bcaa on muscle recovery and inflammatory response following acute exercise.

participants, both females and males, will perform an acute bout of exercise. a bout of exercise that will involve multiple drop jumps. prior to and post exercise, functional outputs will be measured and blood will be collected to quantify the inflammatory response. the protocol will involve attending the laboratory on 6 occasions over a two week period to complete the above measures.

Eligibility criteria:
inclusion criteria: * health recreationally active males and females. exclusion criteria: * asthma sufferers * people with kidney disease * people partaking in lower limb strength training * people suffering doms in the past 6 months * people already taking dietary supplements, other nsaids, or for example aspirin, alcohol, warfarin, phenytoin, methotrexate, lithium, diuretics, cyclosporine. * people with bone or soft tissue injury within last 12 months * people with gastric problems * people with hypertension * people who have had history of heart failure * people with liver disease * people with connective tissue disorders * people with crohn's disease * people with ulcerative colitis * people with peripheral arterial disease * people with cerebrovascular disease * elderly population * people with allergies to nsaids, omega- 3 fatty acids and bcaas. * people with depression * people with bipolar disorder * people with diabetes * females who are pregnant * people who have hiv / aids
cbd-microglia pet study

Conditions: CBD; Healthy

Summary: this study aims to examine the effect of cannabidiol (cbd) pre-treatment on brain microglial activation in healthy human subjects. secondarily, this study aims to examine the effect of cannabidiol (cbd) pre-treatment on central pain-sensitization in healthy human subjects.

this study aims to examine the effect of cannabidiol (cbd), pre-treatment, as epidiolex, on brain microglial activation in healthy human subjects using \[11c\]pbr28 pet imaging. secondarily, this study aims to examine the effect of cannabidiol (cbd) pre-treatment on central pain-sensitization in healthy human subjects. lastly, this research study will also examine the relationship between brain microglial activation and central pain sensitization with cbd pre-treatment.

Eligibility criteria:
inclusion criteria: 1. men and women aged 18- 55 years 2. no significant medical or neurological illness 3. no implanted metal devices that may pose a risk during mri scanning 4. within the annual permissible radiation exposure 5. able to provide written informed consent. exclusion criteria: 1. current use of any medications 2. presence of metal in the body 3. pregnancy or lactation

Keywords: control pet scan mri scan central pain-sensitization cannabidiol
vivifrail program in improving the frailty and physical function in the elderly

Conditions: Frailty; Physical Activity; Cognitive Function

Summary: the global population is aging, and taiwan has become an aging society. the aging population continues to rise. when the physical function and mental state of the elderly gradually decline, it is easy for the elderly to enter a state of physical weakness. weakness is the decline in the reserve capacity of the physiological system. it is also related to geriatric syndrome, causing falls, hospitalization, disability, death, and increased medical costs, burden on primary caregivers, and reduced quality of life for the elderly. physical exercise training has been considered to be an effective strategy to prevent and delay disability and frailty, so this study uses the vivifrail program for the elderly. a family-based 12-week exercise program, including: resistance, strength, balance, flexibility and cardiorespiratory endurance exercise training, performed five days a week, at least 45-60 minutes each time, so that the elderly can exercise at home, it can also improve physical function and improve the quality of life. this study adopts a randomized controlled trial (rct) with a one-group pretest-posttest design, with pre-frail and frail elderly as the research objects, and uses comprehensive assessment of the elderly to understand the physical function of the elderly status, vivifrail for the elderly was provided for abnormal physical function items, and post-test evaluation was carried out 4 weeks and 12 weeks after the intervention. in taiwan, there is no research on vivifrail for the frail elderly. in view of this, it is hoped that through the vivifrail program and the follow-up of case managers, multi-faceted and continuous integrated care can be provided. improve and maintain the physical function of the frail elderly for reference in the daily care of the elderly in the future.


Eligibility criteria:
inclusion criteria: 1. ≧65 years old and above. 2. pre-frail and frail cases assessed by frail fried's frail phenotype. 3. clear consciousness, willing to accept interviewers, able to communicate in chinese and taiwanese. 4. those who can cooperate with physical activities and have adl ≥ 60 points. exclusion criteria: 1. those who cannot cooperate with the interventional care plan. 2. elderly who are seriously ill or terminally ill. 3. people living in institutions. 4. incompatibility and exclusion: acute myocardial infarction or recent unstable angina, poorly controlled atrial or ventricular arrhythmia, dissected aortic aneurysm, severe aortic stenosis, endocarditis/acute cardiac capsulitis, uncontrolled hypertension, acute thromboembolism, acute or severe heart failure, acute or severe respiratory failure, uncontrolled postural hypotension, acute incompensated diabetes mellitus, or uncontrolled hypoglycemia, past month there is a fracture (muscle strength training).