Kornimate/medical-research-clean huggingface dataset:
cannabis for spasticity in multiple sclerosis

Conditions: Multiple Sclerosis

Summary: the purpose of this study is to learn if the use of inhaled cannabis (marijuana) and oral cannabinoid (dronabinol, marinol or thc, which is an active ingredient of marijuana) is safe and effective in reducing the symptoms of spasticity and tremor in patients with secondary-progressive or primary progressive multiple sclerosis.

the treatment of ms is far from satisfactory. for acute attacks, high dose corticosteroids seem to reduce the duration of attacks and to reduce the likelihood of future attacks. immunomodulatory agents, available in this disease over the last decade, reduce the frequency of severe attacks by about one third. the remainder of the treatments are symptomatic, aimed at reducing the disability already present. recent research into the cb1 and cb2 cannabinoid receptor systems suggest that cannabis may have the potential for affecting both the pathogenic mechanisms and the symptoms of ms. in light of the autoimmune hypothesis of the etiology of ms, thc could directly alter immune function in a manner that might reduce (or increase) the primary pathology of the disease. comparisons: three treatment arms will be compared: 1) inhaled cannabis and oral placebo, 2) inhaled placebo and oral thc, 3) inhaled placebo and oral placebo, with the effects of these agents analyzed at thirty and sixty days.

Eligibility criteria:
inclusion criteria: * diagnosis of clinically definite multiple sclerosis as defined by poser criteria * primary or secondary disease course * moderate or severe spasticity * age 21 or older exclusion criteria: * preexisting pulmonary conditions, including poorly controlled asthma, chronic bronchitis, emphysema, bronchiectasis, and other significant pulmonary disorders * preexisting cardiac conditions, including ischemic heart disease, congestive heart failure, and other significant cardiac disorders * inability to abstain from tobacco or marijuana smoking, or use of alcohol or sedative or hypnotic medications during the duration of the study * past history of abuse of recreational drugs, including marijuana and alcohol in the last 12 months * history of or currently meets dsm-iv criteria for dependence on cannabis * use of cannabis, marijuana, or thc in the last two weeks * preexisting dementia, mania, depression, or schizophrenia or other poorly controlled psychiatric illness * exacerbation of ms within 30 days prior to screenin visit * current use of cyclophosphamide, mitoxanthrone, or cladribine * arthritis, bony and soft tissue disorders interfering with spasticity measures * inability to provide informed consent * recent cannabis use of more than twice per week one month prior to study entry

Keywords: cannabis marijuana multiple sclerosis spasticity
usefulness of microbiological tests in community-acquired pneumonia

Conditions: Community-Acquired Pneumonia

Summary: the hypothesis is that community-acquired pneumonia is usually a monomicrobial infection. therefore, early detection of the etiology allows to select the most active, narrow-spectrum, and cheap, and less toxic antibiotic agent.

in community-acquired pneumonia, identification of the etiologic agent has theoretically important advantages. for individual patients, it facilitates the administration of a targeted, narrow-spectrum antibiotic therapy that may improve the efficacy of treatment, and reduces risks of antibiotic-related toxicity. for the community, microbiologic results contribute to understanding the local microbial epidemiology of community-acquired pneumonia and the antimicrobial resistance patterns of pathogens, information that is essential in the instauration or modification of empiric treatment regimens. guidelines recommend that all admitted patients with community-acquired pneumonia should have a collection of two sets of blood cultures, a good quality sputum sample for gram stain and culture, a sample of pleural fuid if present and, for severe patients, an urine sample for antigen detection. in contrast, several prospective studies (usually without include urinary tests) concluded that these microbiological studies have limited value in the management of patients admitted with community-acquired pneumonia. in addition, microbiological studies could provide erroneous or incomplete information. thus, investigations has showed false-positive results from pneumococcal antigen detection in urine caused by a frequent persistence of positivity after infection or a nasopharyngeal or bronchial colonization. other authors suggested that community-acquired pneumonia is a polymicrobial infection; consequently, despite the detection of a true microorganism, treatment needs to be also addressed against other potential pathogenic agents. the purpose of the study is to assess the clinical and the economic derived from the initial microbiological studies, including antigen detection tests in urine for streptococcus pneumoniae and legionella pneumophila, in patients with community-acquired pneumonia. the hypothesis is that community-acquired pneumonia is usually a monomicrobial infection. therefore, early detection of the etiology allows to select the most active, narrow-spectrum, and cheap, and less toxic antibiotic agent.

Eligibility criteria:
inclusion criteria: * age: 18 years and above * clinical and radiological diagnosis of community-acquired pneumonia * informed consent of patient * hospital admission exclusion criteria: * prior hospital admission (less than 15 days) * alternative diagnosis at the discharge * immunosuppression (hiv infection, immunosuppressive therapies, neutropenia) * risk factors for unusual etiologies * patient is pregnant

Keywords: community-acquired pneumonia microbiological tests urinary antigen selection of antibiotic treatment
selected aspects of mental health of athletes

Conditions: Mental Health Disorder

Summary: the study will assess the prevalence of mental health problems among different athletes. the study is based on the application of the battery of psychodiagnostic questionnaires, which were chosen aiming at investigating the prevalence of different symptoms related to problems in mental health or disorders. this descriptive cross-sectional study will undertake sample with athletes categorized by the quality of their achievement.

in the field of sports, there is a lot of knowledge about sports injuries, nutrition and regeneration. much less is known about mental health among athletes. the investigators often think that the incidence of mental problems is low among top athletes. as the main cause of this misconception, the authors attribute the idealization of sports and athletes. both the professional and the lay public are often of the opinion that only mentally strong individuals can be successful, which of course means that there is no place in the highest level for individuals with mental problems and disorders. the clinical study will be performed with 400-500 athletes of both genders aged 18 to 40, from slovenia. the investigators will invite all athletes who have been categorized in the current year and classified into the membership category, i.e. national, international, world or olympic class (there were 500 at the last categorization) and they compete in various sports disciplines. the study will be designed as a cross-sectional study. for the purpose of the research, the investigators will use a battery of psychodiagnostic questionnaires consisting of five parts: demographics and sport characteristic, depression symptomatic, anxiety symptomatic, eating problems, alcohol use and abuse and resilience characteristics of individual athlete.

Eligibility criteria:
inclusion criteria: * included in competitive play * is a professional athlete or participates in organized professional sports activities exclusion criteria: * present injuries * recreational athletes * any other significant diseases
simulation of adenosine push methods for treatment of svt using agitated saline visualized by ultrasound

Conditions: Supraventricular Tachycardia

Summary: supraventricular tachycardia (svt) is an abnormally fast heart rhythm arising from improper electrical activity in the upper part of the heart. svt is commonly treated with adenosine using three different iv administration techniques. however, it is not well known which of these three techniques is the quickest or most likely to reach the heart in order to stop svt. this study will simulate each of those techniques in an investigator-blinded procedure. intravenous agitated saline, used as a surrogate for a dose of adenosine, will be administered to healthy volunteers using all three techniques and monitored using bedside ultrasound to observe their efficacy and speed in reaching the right side of the heart.


Eligibility criteria:
inclusion criteria: * volunteers aged 18 years and older * able to understand and provide signed consent for the study * must be healthy; not being actively treated for any condition that requires active medical intervention or monitoring to avert serious danger to the participant's health or well-being, as evaluated by study investigator exclusion criteria: * non-english speaker * those with contraindications to peripheral iv placement, such as infection or other contraindication noted from evaluation by study investigator * pregnancy
a study to evaluate the safety, tolerability, cellular kinetics, pharmacodynamics, and efficacy of p-cd19cd20-allo1 in participants with severe, treatment-refractory systemic lupus erythematosus (sle)

Conditions: Systemic Lupus Erythematosus

Summary: the purpose of this study is to evaluate the safety and tolerability of p-cd19cd20-allo1 in participants with highly active, severe, refractory sle with or without lupus nephritis (ln). this study includes a dose-escalation stage followed by an expansion stage. it will also evaluate the cellular kinetics (ck), pharmacodynamics (pd), and efficacy of p-cd19cd20-allo1.


Eligibility criteria:
key inclusion criteria: 18-75 years old sle diagnosis per 2019 eular/acr classification criteria ≥ 24 weeks autoantibody positive and low complement at screening treatment refractory: failed ≥ 2 treatments for at least 3 months highly active disease: sledai-2k ≥ 8 (excluding alopecia, headache, and fever; additional protocol-specified requirements to enhance specificity of findings) bilag-2004 cat a in ≥ 1 organ system and/or cat b in ≥ 2 organ systems (excluding constitutional, musculoskeletal, and/or mucocutaneous organ systems for category b) pga score ≥ 1.0 on a 0 to 3 vas for patients with lupus nephritis: biopsy-proven class iii or iv (± class v) active ln per 2018 isn/rps criteria within 12 months of screening modified nih activity index ≥ 1/24 upcr ≥ 1g/g key exclusion criteria: participants who are pregnant, breastfeeding, or intend to become pregnant within the timeframe in which contraception is required prior treatment with car t-cell therapy, b-cell-targeting t-cell-dependent bispecific antibody, gene therapy product, total body irradiation, allograft organ transplant, or hematopoietic stem cell transplant significant organ impairment (renal, hepatic, cardiac, or pulmonary) or uncontrolled medical disease which, in the investigator's opinion would preclude patient participation or that may require treatment with systemic corticosteroids or immunosuppressants during the study active severe or unstable neuropsychiatric disease protocol-specified active or chronic infections, recent major episode of infection high-risk medical conditions (e.g. high bleeding risk, history of cancer, recent major surgery, history of hlh/mas, substance abuse within the previous year) other protocol-defined inclusion/exclusion criteria apply

Keywords: lupus nephritis car-t therapy
a study of mk-3009 in japanese patients with skin or blood stream infections caused by methicillin-resistant staphylococcus aureus (mk-3009-002)

Conditions: Staphylococcal Infection

Summary: the study investigates the efficacy and safety of mk-3009 in participants with skin infections, septicemia and right-sided infective endocarditis (rie) caused by methicillin-resistant staphylococcus aureus (mrsa).


Eligibility criteria:
inclusion criteria: * both sexes, aged 20 years or older * japanese participants with skin and soft tissue infections, septicemia, or rie known or suspected to be caused by mrsa * written informed consent exclusion criteria: * participants with skin and soft tissue infections that can be treated by surgery alone * participants with pneumonia
probiotics in adults: do they improve atopic dermatitis?

Conditions: Adult Atopic Dermatitis

Summary: probiotics are suggested to have beneficial effects in atopic dermatitis (ad) treatment and prevention but their precise role is not yet clear. the aim of this randomized double blinded active treatment vs placebo study was to evaluate clinical efficacy of intake of a combination of two probiotics (lactobacillus salivarius ls01 and bifidobacterium breve br03) for the treatment of adult ad patients. the rationale for the use of probiotics in the treatment of atopic dermatitis would be due to some experimental hypotheses: 1. the use of these microbial agents at an early age seems to play an important role in inducing immunity t type 1 (th1) and inhibit the development of a th2 response ige mediated 2. the normal intestinal flora (including probiotics) would play an important role in inducing immunological tolerance 3. the hygiene hypothesis that the reduced bacterial environment would favour a type 2 response t and the development of allergic diseases


Eligibility criteria:
inclusion criteria:adults aged 18-55 years between * diagnosis of da moderate and / or severe, as assessed by the use of a standardized index of severity of ad (scorad = scoring atopic dermatitis index) (42), prepared by the european task force for atopic dermatitis exclusion criteria:allergic contact dermatitis (acd), active * in the absence of known food allergy elimination diet * chronic diseases (autoimmune diseases, copd, heart disease, irc, cns disease, chronic gastrointestinal diseases, diabetes, congenital or acquired immunosuppression) * pregnancy and / or lactation * treatment with probiotics in the 6 months preceding enrollment * treatment with steroids and antihistamines systemically in the three months prior to enrollment * topical treatments with immunomodulators (tacrolimus or pimecrolimus) in the three months prior to enrollment * acute or chronic infectious diseases * pre-existing hypersensitivity to components contained in the probiotic
clinical evaluation of stability of implants placed in partially edentulous maxilla with poor bone quality via new reverse drilling technique versus osteotome technique.

Conditions: Dental Implant

Summary: the study will compare between osteotome technique and new reverse drilling technique in the placement of dental implant in posterior maxilla , primary outcome will be implant stability that will be measured by periotest device . follow up for 6 month. secondary outcomes will be crestal bone loss , pain and swelling.


Eligibility criteria:
inclusion criteria: 1. partially edentulous patients in the maxillary posterior region. 2. systemically healthy patient. 3. presence of proper inter-arch space for placement of the implant prosthetic part. 4. sufficient bone height and width for implant placement (bone height ≥10mm and bone width ≥6mm). 5. non-smoker. 6. patients who are ≥ 20 years old. 7. good oral hygiene. 8. acceptance of a one year follow-up period. 9. informed consent is provided by the patient. exclusion criteria: 1. patients with systemic conditions that may interfere with implant stability, 2. patients with local pathological defects related to the area of interest. 3. unmotivated, uncooperative patients with poor oral hygiene. 4. patients with habits that may jeopardize the implant longevity and affect the results of the study such as alcoholism or parafunctional habits. 5. inadequate inter-arch space for implant prosthetic part
uncontrolled disinformation about regional anesthesia and pregnant patients.

Conditions: Regional Anesthesia; Anxiety; Social Media Addiction; Spinal Anesthesia; Fear Anxiety

Summary: nowadays, hundreds of information about regional anesthesia are accessed from any internet search engine when a question is written about the methods of anesthesia that can be applied during c/s. this information may have positive or negative effects on the patient, as well as include uncontrolled, unsupervised comments, articles and images. our aim is primarily to evaluate whether our patients are exchanging information via social media or the internet and the effects of these shares on their concerns.

social media has become a place to receive and share information today, especially for women of childbearing age. according to a study published in 2019, 78% of social media users are women and 80% of them are in the 18-40 age range. again, studies have shown that women often use a large number of alternative platforms to receive or share information about pregnancy and parenting. it has been shown that there are 3 different reasons why patients follow medical content on social media. behaviorally, patients can be self-healing with the information they receive; cognitively, the search for information about their own condition and the desire to understand their condition is the desire to be able to share common feelings with other people who are in the same situation emotionally. anxiety develops in the preoperative period in 21-25% of cesarean section patients. this anxiety response can cause premature and low birth weight baby birth by vasoconstricting the uterine artery through the autonomic central nervous system. it is common for pregnant women who already have concerns before the cesarean section that will take place to look for information about both the surgery and the anesthesia method that will be applied. studies including patients who were watched preoperative anesthesia videos about the anesthesia technique, has showed low anxiety levels. however, this videos were custom made videos by the organizations such as hospitals, universities. nowadays, hundreds of information about regional anesthesia are accessed from any internet search engine when a question is written about the methods of anesthesia that can be applied during c/s. this information may have positive or negative effects on the patient, as well as include uncontrolled, unsupervised comments, articles and images. our aim is primarily to evaluate whether our patients are exchanging information via social media or the internet and the effects of these shares on their concerns

Eligibility criteria:
inclusion criteria: * asa i-ii, who speaks and writes turkish exclusion criteria: * psychiatric illness

Keywords: social media anxiety regional anesthesia
effect of functional assessment and immediate rehabilitation of ed admitted elderly with reduced functional performance

Conditions: Functionally-Impaired Elderly

Summary: background: illness and hospitalisation, even of short duration, pose separate risks for permanently reduced functional performance in elderly medical patients. functional assessment in the acute pathway will ensure early detection of declining performance and form the basis for mobilisation during hospitalisation and subsequent rehabilitation. for optimal results rehabilitation should begin immediately after discharge. the aim of this study is to investigate the effect of a systematic functional assessment in the emergency departments (ed) of elderly medical patients with reduced functional performance when combined with immediate post-discharge rehabilitation. method/design: the study is a two-way factorial randomised clinical trial. participants will be recruited among patients admitted to the ed who are above 65 years of age with reduced functional performance. patients will be randomly assigned to one of four groups: 1) functional assessment and immediate rehabilitation; 2) functional assessment and usual rehabilitation; 3) usual assessment and immediate rehabilitation; 4) usual assessment and usual rehabilitation. primary outcome: 30-second chair-stand test administered at admission and two weeks after discharge. we hypothesise that such assessment in the ed or/and immediate rehabilitation will result in sustained or improved performance in comparison to regimen in which neither of these interventions are offered.


Eligibility criteria:
inclusion criteria: * medical patients of 65 years of age or older admitted to the ed * can speak and understand danish * resident in either of the two included municipalities * can report personal data and decide on consent * are able to sit on an chair and perform ≤ 9 repetitions at the 30-s. chair-stand test exclusion criteria: * patients suffering from a progressive neurological or cognitive deficit or disease. * patients ordinarily unable to walk

Keywords: functional assessment rehabilitation cross-sectorial cooperation
assessment of circulating fubctional mitochondrias in vitiligo patients

Conditions: Skin and Connective Tissue Diseases

Summary: to compare the level of circulating functional mitochondria in the serum of vitiligo patients as compared to controls


Eligibility criteria:
inclusion criteria: * patients with non segmental vitiligo, * atopic dermatitis, psoriais, alopecia areata, * 1st degree relative of vitiligo patients. exclusion criteria: * segmental or mixed vitiligo, * personnal history of other autoimmune disorders, * oral use of antioxidant, * pregant women
is laryngeal ultrasound useful in the assessment for ilo? a protocol for a two-stage exploratory pilot study

Conditions: Vocal Cord Dysfunction; Asthma Brittle; Inducible Laryngeal Obstruction; Paradoxical Vocal Fold Motion

Summary: this study is a feasibility study to see if an ultrasound scan of the vocal cords can detect narrowing of the vocal cords as seen in a condition called inducible laryngeal obstruction (the vocal cords narrow or close on breathing in, which makes it very difficult to breathe).

this study aims to help understand whether viewing the vocal cords with an ultrasound device is useful to detect the movement of the vocal cords during breathing. this study is useful, as some people who have abnormal movements of the vocal cords on breathing in find it more difficult to breathe in, and often this leads to a big impact on their quality of life. it may also mean they are on medications that they may not need not be on, as abnormal movements of the vocal cords can often be mistaken for asthma, so they may have been placed on asthma medication when they may not need to be. usually, the way the abnormal movements of the vocal cords are seen now is via a small camera is placed via the nose into the throat to directly look at the vocal cords. some people find this uncomfortable and may have to wait for a long time for it to happen. also, this procedure is expensive, and is done in an endoscopy theatre, which may make it more daunting for some people, and make the wait longer. there are only a few centres that do these assessments with the camera, so people may have to travel some distance to have an assessment. it is hoped, by doing this study, the investigators can see whether ultrasound can help assess if people have abnormal vocal cord movements when they breathe in. this will be done in 2 stages, one with healthy volunteers, and the second stage in patients who have been referred for assessment of their vocal cords to see if they have abnormal movements when breathing in. the investigators will also ask the volunteers and patients what their experience of having the ultrasound was like, and will ask the patients in the study how the ultrasound scan felt, when compared to the camera test

Eligibility criteria:
inclusion criteria: healthy volunteers: * no definite signs or symptoms of vocal fold paralysis * no voice change * no history laryngeal surgeries * no history of pathology * no uncontrolled respiratory disease exclusion criteria: * participants with a known vocal fold pathology * participants with a history of head and neck surgery.

Keywords: inducible laryngeal obstruction ultrasound