Kornimate/medical-research-clean huggingface dataset:
auditory-perceptual training via telepractice

Conditions: Speech Sound Disorder

Summary: the objective of this study is to measure the effects of online perceptual training on perception and production in children with rse who exhibit atypical perception relative to norms from our lab-based pilot data. in a multiple-baseline across-subjects design, 10 children with rse will begin in a baseline phase probing perceptual acuity for /r/. perceptual training with multiple types of stimuli will be initiated in a staggered fashion. production probes elicited before and after treatment will assess the extent to which perception gains transfer to /r/ production.

following the initial evaluation to determine eligibility, participants will be enrolled in a baseline phase in which perception and production abilities will be probed but not treated. in a multiple-baseline across-subjects design with randomization, the 10 participants will be randomly assigned to transition from the baseline to the treatment condition at one of 7 possible points, ranging from 4 to 10 baseline sessions. after baseline sessions, perceptual training will be delivered in twelve 30-minute sessions occurring 3 times per week for 4 weeks. the training is fully computerized and can be self-administered, but a study clinician will attend one session per participant per week to ensure attention to study tasks. each session will feature three listening tasks of approximately equal duration. following perceptual training, participants will receive 4 60-minute sessions of production training completed over two weeks.

Eligibility criteria:
inclusion criteria: * must be between 9;0 and 15;11 years of age at the time of enrollment. * must speak english as the dominant language (i.e., must have begun learning english by age 2, per parent report). * must speak a rhotic dialect of english. * must pass a pure-tone hearing screening at 20db hl * must pass a brief examination of oral structure and function. * must exhibit less than 30% accuracy, based on consensus across 2 trained listeners, on a probe list eliciting rhotics in various phonetic contexts at the word level. * must exhibit no more than 3 sounds other than /r/ in error on the gfta-3 exclusion criteria: * must not receive a t score more than 1.3 sd below the mean on the wechsler abbreviated scale of intelligence-2 (wasi-2) matrix reasoning * must not receive a scaled score of 7 or higher on the recalling sentences and formulated sentences subtests of the clinical evaluation of language fundamentals-5 (celf-5). * must not have an existing diagnosis of developmental disability or major neurobehavioral syndrome such as cerebral palsy, down syndrome, or autism spectrum disorder

Keywords: speech sound disorder auditory perception articulation
impact of metabolite supplementation to restore mitochondrial dysfunction during septic shock: a preclinical study

Conditions: Septic Shock; Multiple Organ Failure

Summary: septic shock is defined as a subset of sepsis with severe metabolism alterations, leading to organ failure. septic shock is associated with a high mortality, around 40% according to the sepsis 3 definition. metabolic alterations are responsible for lactic acidosis, and results in mitochondrial dysfunction. this study aims at evaluate the impact of exogenous metabolites on restoring mitochondrial function in septic shock patients with lactate acidosis. mitochondrial metabolism (quantitative analysis, mitochondrial function) in intact peripheral blood mononuclear cells (pbmc) will be isolate and analyse from patients at the early phase of septic shock (admission), at day 2 and 4. participant's medical history will be recorded: renal and liver metabolism, severity scores and outcomes and the need for supportive care in the intensive care unit (icu) until 28 days after admission. furthermore, the investigators will evaluate wether selected metabolites added to the cell culture medium may improve mitochondrial metabolism.

in this prospective study, the investigators will include patients admitted to the medical icu of angers university hospital and meeting the sepsis-3 criteria for the definition of septic shock (sequential organ failure assessment (sofa) score \> 2, hyperlactatemia \> 2 mmol/l and sepsis). blood samples will be collected during the usual care of initial resuscitation and analyzed in the laboratory inserm (institut national de la santé et de la recherche médicale) u1232 (university hospital of angers). mitochondrial metabolism will be analyzed in freshly isolated pbmc and after culture for 1-3 days, with or without the addition of selected metabolites to the cell culture medium. the evolution of ketogenesis, mitochondrial function, acidobasic status will be assessed across the time (blood samples at day 2 and 4). survival, renal and liver metabolism, severity scores and outcomes and the need for supportive care in the intensive care unit (icu) until 28 days after admission will be recorded.

Eligibility criteria:
inclusion criteria: * all patients aged 18 or more * patients with criteria for septic shock according to sepsis 3 definition (presumed sepsis, with persisting hypotension requiring vasopressors to maintain mean arterial pressure \> 65 mmhg and having a serum lactate \> 2 mmol/l despite adequate fluid expansion). * admitted in the icu of angers university hospital exclusion criteria: * minor patients (aged less 18) * patient subject to legal protection measures * refusal of the patient or his family * preexisting mitochondrial disease * patient with aplasia * pregnant or parturient women

Keywords: mitochondrial dysfunction
ultrasound guided rhomboid intercostal plane block versus thoracic erector spinae plane block in upper abdominal surgery

Conditions: Ultrasound; Rhomboid Intercostal Plane Block; Thoracic Erector Spinae Plane Block; Upper Abdominal Surgery

Summary: the aim of the work is to evaluate the analgesic efficacy of ultrasound guided rhomboid intercostal plane block versus ultrasound guided thoracic erector spinae block in patients undergoing upper abdominal surgery.

abdominal surgery is one of the most definitive and mainstay treatment options for abdominal pathologies in clinical practice. acute postoperative pain is a major challenge in the postoperative period. the improved safety and efficacy that ultrasound brings to regional anesthesia helped promote its use and realize the benefits that regional anesthesia has over general anesthesia, such as decreased morbidity and mortality, superior postoperative analgesia, cost-effectiveness, decrease postoperative complications and an improved postoperative course .

Eligibility criteria:
inclusion criteria: * patients aged 21-65 years. * both gender. * american society of anesthesiologists (asa) classification i-ii. * presented for elective upper abdominal surgery. exclusion criteria: * patients refused to participate. * patients with known or suspected allergy to the used medication. * patients with preoperative chronic pain. * patients with major cardiac, renal, respiratory, or hepatic disease. * patients with potential risk of coagulopathy. * obese patients with body mass index (bmi) \>35.
effect of psycho-education on gestational weight gain and anxiety/depression in obese pregnant women

Conditions: Obese Pregnant Women

Summary: prepregnancy obesity, defined as a body mass index (bmi) of 30kg/m² or more, shows a strong association with pregnancy and birth complications for both the mother and her child. most consequently reported maternal risks include an increased risk for gestational diabetes, hypertension and pre-eclampsia, increased incidence of induction of labour, operative delivery, postpartum haemorrhage, anaesthetic risks as well as risk for infections and thromboembolic complications. fetal risks include miscarriage, neural-tube defects, heart defects, macrosomia and stillbirth. initiation and continuation of breastfeeding is more complicated in obese women than in normal weight women. also in later life chronic diseases can put the mother and her baby's health at risk. the institute of medicine (iom) guidelines suggest a gestational weight gain (gwg) to be limited to 5 - 9 kg (11-19,8 lb) in obese women in order to minimize the synergetic negative health consequences of excessive weight gain for both the obese mother and her child. preventing excessive weight gain during pregnancy and postpartum weight retention is also important in the prevention of overweight and obesity among women of reproductive age. obese women in general have a poor diet quality and are more exposed to psychosocial factors like anxiety and feelings of depression than normal weight women. the aim of this project is to perform a randomized controlled trial (rct) in order to evaluate the effects of life-style intervention (psycho-education by a midwife during 4 prenatal sessions) on pregnancy and birth outcomes. main dependent variables are gestational weight gain and anxiety and depression. obesity is a modifiable risk factor and optimizing an adequate gestational weight gain with attention to psycho-social factors, can reduce the need for adverse perinatal outcomes.


Eligibility criteria:
inclusion criteria: * less than 15 weeks pregnant exclusion criteria: * multiple pregnancy * preexisting diabetes * primary need for nutritional advice * inadequate knowledge of dutch language
radioablation with or without androgen deprivation therapy in metachronous prostate cancer oligometastasis

Conditions: Oligometastatic Prostate Cancer

Summary: a randomized phase ii clinical trial (radiosa trial: radioablation with or without androgen deprivation therapy in metachronous prostate cancer oligometastasis). the aim is to compare time to progression between the two study arms: sbrt only or sbrt and hormonotherapy (adt). the primary objective is to compare the progression-free survival (pfs) defined as the absence of new metastatic lesions (local, regional or distant) between the two arms. the secondary endpoints include the comparison of overall survival (os), biochemical progression-free survival (bpfs), adt-free survival, local control, treatment-induced acute and late toxicity, time to castration-resistant disease and qol between the two arms; the development of a dedicated biobanking (collection of plasma and serum) for further biological investigation of predictive/diagnostic factors for personalized treatment; the preliminary evaluation of prognostic biomarkers; the correlation between imaging-derived parameters and treatment outcome.


Eligibility criteria:
inclusion criteria: * histologically proven initial diagnosis of adenocarcinoma of the prostate; * biochemical relapse of pca following radical local prostate treatment (radical prostatectomy, primary radiotherapy or radical prostatectomy +/- prostate bed adjuvant/salvage radiotherapy) +/- adt according to the european association of urology (eau) guidelines 2016 \[18\] or after any salvage therapy if biochemical progression is diagnosed in the context of castration sensitive pca; * nodal relapse in the pelvis, extra-regional nodal relapse (m1a), bone metastases (m1b) on ch-pet/ct or wbmri with a maximum of 3 lesions; * serum testosterone level \>50 ng/dl at the time of randomization (castration sensitive pca) * eastern cooperative oncology group (ecog) performance status 0-1; * age ≥18 years; * written informed consent signed exclusion criteria * serious concomitant comorbidities or contraindication to sbrt and/or adt; * previous invasive cancer (within 3 years before the prostate cancer diagnosis) apart from non-melanoma skin malignancies; * no ability to complete questionnaires about qol; * presence of mental diseases that cannot ensure valid informed consent;
migraine attack pain phase prediction study

Conditions: Migraine; Migraine Headache; Migraine Disorders; Migraine Without Aura; Migraine With Aura

Summary: the study of the ability to predict pain in a migraine attack, through premonitory symptoms and through an ambulatory monitoring device through real-time recording of hemodynamic variables, is one of the strategic lines of research of the unit. of headaches at the hospital de la princesa since 2013 together with the complutense and polytechnic university of madrid. their results have been reflected in various publications (pagán j, et al. sensors 2015; gago-veiga ab, et al. j pain res 2018) and have promoted the creation of several invention patents.

patients with episodic migraine will be recruited from the monographic headache clinics of the 7 centers participating in the study. these patients, for a maximum period of 2 months, must monitor their hemodynamic variables with a wearable device and record all the clinical characteristics of their migraine attacks. subsequently, with these records, an individualized algorithm will be created for each patient that aims to predict the onset of the migraine attack.

Eligibility criteria:
inclusion criteria: * age between 15 years and 69 years. * diagnosed with migraine by a headache neurologist and according to the criteria proposed by ichd-3. * history of migraine of at least 1 year of evolution. * normal neurological examination. * have given your informed consent. * be able to describe your clinical situation and the characteristics of your headache. * have an average of 10 to 14 migraine days per month in the three months prior to inclusion (high-frequency episodic migraine). * user-level management capacity of "smartphone" type electronic devices. * be able to complete two months of study follow-up. exclusion criteria: * presence of another type of headache, with the exception of headache due to excessive use of analgesic medication. * cognitive deficiency or any other pathology that may prevent or make it difficult for the patient to perform the study correctly. * neurological focus in the examination. * pregnancy or breastfeeding period. * patients with known heart disease or bronchopathy, sjögren\&#39;s syndrome, diabetes mellitus, or hypo/hyperthyroidism. * carriers of pacemakers, neurostimulators or any other electronic device that is considered to make the interpretation of biometric records difficult. * anatomical problem that makes the use of the device impossible. * patients in whom it is expected that a change in migraine preventive treatment or other usual treatment will be possible during the study period.

Keywords: migraine headache predict prediction headache prediction predict headache migraine prediction predict migraine migraine attacks migraine attack headache attack migraine attack prediction predict migraine attack prediction algorithm algorithm
dapagliflozin in the prevention of post-coronary angioplasty acute kidney injury

Conditions: Acute Kidney Injury; Percutaneous Coronary Intervention

Summary: to compare the incidence of acute kidney injury (aki) post percutaneous coronary intervention (pci) in a dapagliflozin treated group versus a group managed with the usual standard of care.


Eligibility criteria:
inclusion criteria: 1. age 18 years or more. 2. scheduled/non-emergent percutaneous coronary intervention (pci). 3. post-index procedure staged pci with at least 14 days from contrast exposure. 4. patient can fully understand the study information and sign informed consent. exclusion criteria: 1. cardiogenic shock /need for inotrope or mechanical pump support. 2. acute kidney injury as defined by kdigo criteria (\<4 weeks) prior to pci. 3. end-stage renal disease prior to pci (on renal replacement therapy). 4. diabetes mellitus type 1. 5. active diabetic ketoacidosis or uncontrolled hyperglycemia (blood glucose \>400 mg/dl). 6. st-segment elevation myocardial infarction undergoing index pci. 7. active genitourinary infection. 8. diagnostic left heart catheterization without pci. 9. patients undergoing zero contrast pci. 10. participation in a randomized controlled pharmaceutical or treatment-related cardiac or pulmonary clinical study within 1 month prior to randomization. 11. coexistent hemodynamically significant valvulopathy (symptomatic and/or severe). 12. patients with acute heart failure admission \< 30 days prior to pci. 13. intercurrent illness resulting in volume depletion and hypotension (map\<60 mmhg). 14. patients with a kidney transplant. 15. any contrast exposure within 14 days. 16. patients with estimated glomerular filtration rate (egfr) \< 25 cc/min (recommended egfr threshold by food and drug administration labeling). 17. patients with an active intrinsic inflammatory or autoimmune renal pathology. 18. women of child bearing age (\<50 years old). 19. prison inmates

Keywords: sglt2 inhibitor dapagliflozin aki pci angiography
an investigation of the safety of 4 different doses of autologous muscle derived cells as therapy for stress urinary incontinence

Conditions: Stress Urinary Incontinence; Cell Therapy

Summary: this is a clinical investigation approved by us fda and canadian health authority to study the safety and potential effectiveness of the autologous muscle cells for the treatment of stress urinary incontinence.


Eligibility criteria:
inclusion criteria: * patient has sui with normal detrusor activity confirmed with urodynamics * patient has bladder capacity \>200 ml * patient's incontinence has not shown any improvement for at least -6 months * patient has failed prior treatments (e.g., behavior modification, bladder exercises, biofeedback, electrical stimulation, bulking injections, urethral suspensions and/or drug therapy) exclusion criteria: * patient has known vesicoureteral reflux, vaginal prolapse beyond the introitus, or other significant pelvic floor abnormalities with high pressure instability * patient has a neuromuscular disorder (e.g., muscular dystrophy, multiple sclerosis) * patient has uncontrolled diabetes * patient is pregnant, lactating, or plans to become pregnant during the course of the study * patient is morbidly obese (defined as 100 pounds over their ideal body weight, or bmi ≥40) and would not be expected to benefit from treatment * patient has current or acute conditions involving cystitis or urethritis * patient is scheduled to receive radiation treatment to the vicinity * patients with a history of radiation treatment to the urethra or adjacent structures
efficacy of different electrical stimulation placement in patients with overactive bladder syndrome

Conditions: Overactive Bladder Syndrome

Summary: this experiment is expected to understand the benefits of different settings of electrical stimulation in the treatment of overactive bladder.

this experiment is expected to understand the benefits of different settings of electrical stimulation in the treatment of overactive bladder.the study will adopt a longitudinal research design with randomized quasi-experimental trial.the patients will recruited and be randomly assigned to group a (parasacral transcutaneous electrical stimulation) or group b (intravaginal electrical stimulation). there will be 30 participants in each group. data will be collected 2 times.

Eligibility criteria:
inclusion criteria: * urinary incontinence due to detrusor overactivity * no patients had been taking anticholinergics or tricyclic depressants and none had been treated by pelvic floor exercise, bladder training, or pelvic surgery before entry into the study. exclusion criteria: * stress incontinence * urinary tract infection * neurological disease * genital prolapse higher than stage ii on pop-q system * pregnancy * diabetes mellitus * a history of anti-incontinence surgery and/or prolapse repair * pelvic tumors and previously treated with radiation therapy or antimuscarinic agents * patients who were not cooperative * electrical stimulation contraindications

Keywords: intravaginal electrical stimulation parasacral transcutaneous electrical stimulation
a clinical trial of a psycho-educational intervention to improve pain management after day surgery

Conditions: Postoperative Pain; Chronic Pain

Summary: evidence indicates that postoperative pain after day surgery is inadequately controlled. patients have different experiences and knowledge about how to deal with pain, and the need for information and clarification may vary. the aim of this study is to enhance pain management by academic detailing (patients' current knowledge and motivations are the basis for information) and nurse coaching (frequent and individualized support). the study consists of 4 phases; (1) a pilot study about patients experience with pain after surgery by a structured telephone interview; (2) development of an intervention to improve pain management; (3) implement and evaluate the intervention; (4) evaluate the incidence of chronic pain after day surgery. even if patients are prescribed sufficient doses of analgesics, pain relief is dependent on patients' adherence with the analgesic regimen. psychological factors, such as catastrophizing may also contribute to patients' experience of postoperative pain. strategies that may be more effective than general information concerning surgery and pain management is academic detailing and nurse coaching, and will be used as frame for the intervention. hypothesis: over the seven days after surgery patients in the intervention group report; * higher adherence with the analgesic regimen, * have less pain intensity and pain interference with function and * lower severity of side effects compared to the control group.


Eligibility criteria:
inclusion criteria: * \> 18 years of age; * able, to read, write, and understand norwegian; * are scheduled for orthopedic (shoulder, bunnies), or breast reconstruction surgery and * have a telephone line. exclusion criteria: * staying overnight in hospital

Keywords: day surgery orthopedic surgery breast reconstruction surgery