Kornimate/medical-research-clean huggingface dataset:
the anti-reflux effect of double-flap technique in laparoscopic proximal gastrectomy.

Conditions: Proximal Early Gastric Cancer

Summary: this study is a multicenter, open-label, prospective, randomized parallel-controlled trial. the purpose is to explore whether the incidence rate of reflux esophagitis (re) within 12 months after surgery is non-inferior for the dft group compared to the dtr group.

this study will enroll patients with proximal gastric cancer scheduled to undergo laparoscopic proximal gastrectomy. the patients will be randomly divided into two groups. one group will undergo laparoscopic proximal gastrectomy with double-flap technique (dft) anastomosis, while the other group will undergo laparoscopic proximal gastrectomy with double-tract reconstruction (dtr). the primary endpoint is the proportion of patients who develop reflux esophagitis within 12 months after surgery. the secondary endpoints include postoperative complications, surgery-related indicators, and postoperative nutritional status.

Eligibility criteria:
inclusion criteria: 1. age between 20 and 80 years, regardless of gender; 2. patients diagnosed with gastric cancer through tissue biopsy; 3. eastern cooperative oncology group (ecog) performance status score of 0 or 1; 4. american society of anesthesiologists (asa) classification of i to iii; 5. acceptable for laparoscopic proximal gastrectomy with preoperative examinations (based on endoscopic ultrasound and/or contrast-enhanced computed tomography of the thorax and abdomen) confirming the following oncological features: primary tumor located in the upper part of the stomach (proximal 1/3 of the stomach) or gastroesophageal junction; length of esophageal invasion ≤ 1 cm, tumor maximum diameter ≤ 4 cm; preoperative staging t1-3n0m0 (based on ajcc 8th edition tnm clinical staging); 6. voluntary signing of informed consent. exclusion criteria: 1. received preoperative chemotherapy, radiotherapy, targeted therapy, or immunotherapy; 2. presence of contraindications to surgery; 3. multiple malignant lesions in the stomach; 4. presence of other malignancies that may affect the preservation of stomach function; 5. previous upper abdominal surgery (excluding cholecystectomy); 6. preoperative examination reveals active peptic ulcer; 7. patients who have received or are currently receiving treatment for systemic inflammatory diseases; 8. pregnant or breastfeeding women; 9. conditions deemed unsuitable for participation in this study by the investigator.
talent converter post-approval study

Conditions: Abdominal Aortic Aneurysms

Summary: the primary endpoint is successful secondary endovascular treatment with the talent converter stent graft of subjects having received prior endovascular repair of infrarenal abdominal aortic or aortoiliac aneurysms using the talent or aneurx bifurcated stent grafts, in which there is inadequate proximal fixation, seal, overlapping of modular components or unattainable contralateral limb cannulation. treatment success is defined as a composite of successful vessel access, successful insertion of the delivery system, successful deployment of the converter stent graft at the intended treatment site and absence of type i endoleak at the 1 month follow-up visit.

converter pas is an observational study. patients will receive treatment regardless of study participation. in some cases, patients will be enrolled retrospectively, post implantation.

Eligibility criteria:
inclusion criteria: 1. subjects in whom a vessel access procedure was/will be performed with the attempted introduction of the talent converter stent graft for use according to the indications for use in the instructions for use (ifu) 0-365 days prior to enrollment. 2. subjects who are able to understand the nature of the study and give voluntary informed consent. 3. subjects who are available for follow-up visits. 4. subjects 18 years of age or older. exclusion criteria: 1. subjects in whom an attempted treatment was/will be performed with the talent converter stent graft other than (i.e., primary aui) as a secondary endovascular intervention for patients having received prior endovascular repair with either a talent or aneurx bifurcated stent graft. 2. subjects in whom an attempted treatment was/will be performed with the talent converter stent graft as a secondary endovascular intervention for patients having received prior endovascular repair with a bifurcated stent graft other than (i.e., cook zenith or gore excluder) a talent or aneurx bifurcated stent graft.

Keywords: post-approval observation of patients being treated according to the indications for use for the talent converter stent graft
enovis high ankle sprain brace testing

Conditions: Athletes in Cutting Sports

Summary: the goal of this clinical trial is to learn if a new ankle brace impacts athletic motions. the main questions it aims to answer are: * does it impact motions such as running and cutting? * is it comfortable? researchers will compare 5 ankle bracing conditions. participants will: * perform a running activity * perform a cutting activity * complete a survey


Eligibility criteria:
inclusion criteria: * age 18 to 40 at the time of data collection * english-speaking * not currently pregnant * no history of lower extremity surgery or chronic ankle instability * no ankle injuries that required medical attention or ≥ 7 days of modified physical activity within the last 3 months * currently cleared for all physical activity * comfortable running on a treadmill for 10 minutes at a self-selected pace * have prior experience wearing an ankle brace and / or ankle tape during sport activities * shoe size us men's 7.5-11.5 or women's 9-13

Keywords: syndesmosis ankle sprain ankle bracing
add on study on δ9-thc treatment for posttraumatic stress disorders (ptsd)

Conditions: Posttraumatic Stress Disorders

Summary: stress disorder (ptsd) is a chronic and debilitating anxiety disorder which is widespread in every social level and is very prevalent in outpatient and inpatient settings. a recent open-label study showed that the synthetic cannabinoid receptor agonist nabilone had beneficial effects abolishing or greatly reducing nightmares that persisted in spite of treatment with conventional ptsd medications. furthermore, a big number of patients suffering from chronic ptsd report using smoked marijuana because its tranquilizing effect and sleep quality improvement. according to clinical and epidemiological data different derivates from the cannabis plant are illegally and pervasively consumed by ptsd patients in order to reduce distress. the aim of the proposed study is to broaden the previous observations and to measure the extent to which δ 9-thc will bring to significant improvement on the full spectrum of ptsd symptoms.


Eligibility criteria:
inclusion criteria: * outpatients between the 19-60 years of age with a diagnosis of ptsd. * women must not be currently pregnant and must use a reliable method of contraception for the duration of the study. * subjects must be on stable medication (4 weeks minimum) for their ptsd (symptomatic despite current treatment), must be able to provide written informed consent, must be able adequately understand and comply with the study's instructions and protocol . exclusion criteria: * those not meeting the inclusion criteria and those not able to give informed consent. * women who are currently pregnant or nursing. * those at immediate risk of harming self or others; those who have a clinically significant medical illness or other significant psychiatric illness; * currently abusing alcohol or drugs; * currently being treated with an investigational medication or medication that is contraindicated with cannabinoids; * have a known allergy to cannabis-based products.
communication skill and related factors among oncology nurses

Conditions: Oncology; Nurse; Communication

Summary: this study is a 1-year quantitative method research.data collection will be divided into oncology nurses and cancer patients.to explore the related factors of clinical oncology nurses on the psychological aspects of cancer patients.

background:nurses who care for cancer patients on the front line play an important role in the psychological care, distress assessment and management of cancer patients. most of these cancer patients do not directly express their concerns to the nursing staff. nursing staff should be able to assess and identify psychological needs through verbal and non-verbal messages during the nursing period, and provide effective information, general psychological support and rich psychological support in nursing measures. the ability to communicate empathetically and avoid ignoring psychological needs that may cause distress to the patient. therefore, an in-depth understanding of the first-line tumor nurses interacting with patients, and the related factors that affect communication with patients, such as workload, fatigue, self-confidence, etc., are crucial factors for detecting psychological problems in cancer patients. it directly affects the body and mind of cancer patients, and exploring its related factors is of course an important topic. purpose: understand current clinical oncology nurses, work load, emotional state, self-confidence, comfort ability, empathy and communication ability related factors, and add patients' measurement of nursing staff's communication ability, empathy and satisfaction, through nurses the results of the patients and nurses are closer to the current clinical situation. method:this study is a 1-year quantitative method research. it is a cross-sectional descriptive correlation research, using a structured questionnaire to collect data which will be collected by oncology nurses and cancer patients.

Eligibility criteria:
nurse inclusion criteria: * over 20 years old (inclusive). * nursing staff who are currently working in cancer-related positions and have clinical contact or care for patients. exclusion criteria: * nurse who have resigned. patient inclusion criteria: * over 20 years old (inclusive). * diagnosed as a cancer patient by doctors. * patients who are known disease status. * patients who are currently hospitalized in cancer wards. exclusion criteria: * people with mental illness. * those who are unconscious and unable to complete the interview for this study with language or conversation. * those who are unwilling to accept interviews and participate in research surveys.

Keywords: oncology nurse communication skill
stereotactic radiotherapy of resection cavity for single brain metastasis versus whole-brain radiotherapy after resection

Conditions: Brain Metastases

Summary: adjuvant whole-brain radiation therapy (wbrt) after resection of single brain metastasis is considered as a standard associated with side effects leading to decreased neurocognitive function. the investigators addressed the question whether stereotactic radiotherapy of the resection cavity impairs neurological status and/or cognitive functions in compare to adjuvant wbrt.

patients with surgically removed single brain metastasis are randomly allocated to control or experimental arm. before treatment the mrc neurological status scale is used for assessing neurological status, the eortc qlq-c30 and qlq-bn20 for quality of life and mini-mental state examination to assess cognitive functioning. the control group receive 30gy in 10 fractions of 3gy over 12 days to the whole brain. the patients in the experimental arm are treated with stereotactic radiotherapy to the resection cavity. the dose to the tumor bed is 15-18gy in one fraction or 25gy in 5 fractions. the study hypothesis is that the difference in the 5-months failure free survival rate isn't higher than 25% in experimental arm compared to control arm.

Eligibility criteria:
inclusion criteria: * patients with surgically removed histologically proven metastatic cancer * subtotal or total resection of single brain metastasis * presence of single brain metastasis in mri * karnofsky performance status ≥ 70 * life expectancy \> 6 months (minimal extracranial disease or availability of effective oncology treatment) * no previous history of cranial irradiation * availability of mri * starting radiotherapy within six weeks after neurosurgery * negative pregnancy test for woman * written informed consent exclusion criteria: * dementia and central nervous system diseases leading to higher risk of radiation toxicity * contraindications for mri and/or no patient's tolerance and acceptance of cranial mri * altered level of consciousness * histologically proven metastatic small cell lung cancer

Keywords: stereotactic radiotherapy whole-brain radiotherapy resection cavity
perioperative care in the cancer patient -1, arca-1 study

Conditions: Hematopoietic and Lymphoid Cell Neoplasm; Malignant Solid Neoplasm

Summary: this study investigates the association of blood transfusions given around the time of surgery (perioperative) with complications after surgery (postoperative), cancer progression, and mortality after major oncologic non-cardiac surgery. the administration of blood products is an important clinical therapy to treat life-threatening blood (hematological) disorders (i.e. anemia, coagulation disorders or thrombocytopenia) in patients with cancer undergoing major non-cardiac surgery. on the other hand, the unnecessary exposure of those patients to blood products can be associated with the occurrence of unwanted severe complications and potentially increase the risk of death. an accurate understanding of the short and long-term outcomes, the patterns of blood transfusions, and the triggers of blood product administration may help researchers design and test the safety of perioperative blood transfusions in patients with cancer.

primary objective: i. to evaluate if perioperative blood transfusions are associated with 1-year mortality. secondary objectives: i. to evaluate the association of blood transfusion with postoperative complications, 30 days mortality and cancer progression after major oncologic non-cardiac surgery. ii. to gain knowledge on prevalence and patterns of blood product administration worldwide, the incidence and management of perioperative anemia and the incidence and treatment of perioperative coagulopathies. outline: patients undergo standard of care treatment and their medical records are reviewed at 30 days and at 1 year after surgery.

Eligibility criteria:
inclusion criteria: * patient undergoing major cancer surgery with curative intent * planned length of stay 24 hours after surgery or longer * american society of anesthesiologists physical status (asa) 1-4 * scheduled, non-emergency surgery exclusion criteria: * emergency surgery * palliative surgeries for metastatic disease (non-curative intent) * patients undergoing surgery with minimum risk (\< 1%) of blood transfusion according to each center practice (i.e. simple mastectomy, thyroidectomies or wide-local excisions) * patients undergoing surgery under local anesthesia * patients undergoing ambulatory surgery or planned hospital admission of less than 24 hours
indoor artificial light at night and the relapse risk of schizophrenia

Conditions: Schizophrenia Relapse; Light Pollution

Summary: a randomized crossover trial of alan intervention was conducted in patients with chronic schizophrenia in anhui mental health center from august 15 to september 30, 2022. all participants met the diagnostic criteria for schizophrenia in the fifth edition of the diagnostic and statistical manual of mental disorders (dsm-v). the enrolled patients were in the symptom-stable phase and were regularly prescribed antipsychotics (no change in medication regimen). the diets of all the participants were uniformly supplied during study. patients with infectious diseases, eye diseases, or gastrointestinal diseases, or who used antibiotics at the time of recruitment, were excluded. the wards of the participants were all located in the same inpatient building. all included wards had the same size, layout, lighting and orientation of doors and windows. in normal conditions, each ward retains a small led lamp (the same layout in all wards) at night as a source of lighting. the study was divided into two stages. in the first stage, 10 wards were randomly selected as the intervention group (opaque black tape covering part of the light source), and another 10 wards were selected as the control group (no intervention). after a two-week washout interval, the second stage was carried out, with the two groups interchanging interventions. at the end of each intervention, participants completed a structured questionnaire scale to assess the relapse risk of schizophrenia, and then their fecal samples were collected.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of schizophrenia * regularly taking antipsychotics exclusion criteria: * infectious diseases * gastrointestinal diseases * using antibiotics
compensatory strategies applied to cognitive impairment in schizophrenia

Conditions: Schizophrenia

Summary: the purpose of this study is to determine whether cognitive adaptation training are effective in comparison with conventional treatment, focusing on social functions, symptoms, relapse, re-hospitalisation, and quality of life in outpatients with schizophrenia.

it is estimated that approximately 80% of patients with schizophrenia have reduced cognitive functions, representing problems with attention, verbal memory, short-term memory and executive functions (1-3). these impairments might have an impact on the patients ability to complete rehabilitation programmes, apply learned strategies to social problems, develop work skills and manage daily life (4,5). the effect of cognitive adaptation training has been tested as a psychosocial treatment including training of compensatory strategies in order to sequence patient's adaptive behaviour, showing promising results concerning improved social functions (6). there are however no solid evidence for these statements. the existing few studies investigating the effect of cognitive adaptation training (6-8) are underpowered (small sample sizes) and have a lack of younger patients, which limits the conclusions that can be drawn from the results of the improvement. the present trial employs a prospective design of 26 weeks with a follow-up period of 9 months after inclusion. the study will enroll 164 consecutively recruited participants from three danish out-patient teams for young adults with a first episode of psychosis.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of schizophrenia. * more than one year from referral to the psychiatric clinic. * receive mental medication and continual psychosocial treatment. * participants who have signed informed consent. exclusion criteria: * participants who don't understand or speak danish. * participants who live at an institution or who are long-term hospitalized. * participants who are unwillingly to complete protocol.

Keywords: social adjustment quality of life recurrence hospitalization
treatment of critically ill patients with covid-19 with convalescent plasma

Conditions: SARS-Associated Coronavirus; Covid19; SARS-CoV Infection

Summary: this study aims to collect convalescent plasma and use it as experimental treatment in critically ill covid-19 patients in order to reduce mortality and length of stay in intensive care unit.

this study aims to use convalescent plasma as experimental treatment in critically ill covid-19 patients in order to reduce mortality and length of stay in intensive care unit. donors must have anti-sars cov2 antibodies. recipients must be critically ill covid-19 patients on mechanical ventilation.

Eligibility criteria:
inclusion criteria: * age: 18 years or more. * patient with covid-19 confirmed with nuclear acid testing * critically ill patients with covid-19 on mechanical ventilation. potencially critically ill patients (with acute respiratory distress syndrome, septic shock and/or multiple organ failure) with covid-19. * diagnosed with acute respiratory distress syndrome. * informed consent. exclusion criteria: * no consent. * symptoms for a period longer than 20 days. * not detectable by acid nuclear testing within 48 hours prior to elegibility. * descompensated congestive heart failure, in which receiving 500ml of intrasvascular volume signifies a life risk. * history of severe adverse events or anaphylaxis to plasma components

Keywords: convalescent plasma covid-19 treatment transfusion medicine
patient perceived outcome after total wrist arthroplasty with a new total wrist arthroplasty implant

Conditions: Rheumatoid Arthritis; Osteoarthritis

Summary: total wrist arthroplasty (twa) surgery has developed gradually and can offer patients with rheumatoid arthritis/osteoarthritis reduced wrist pain with mainly preserved wrist range of movement. each year 60-70 patients in sweden are operated with a total wrist arthroplasty. several implants are available on the market and they all have different pros and cons. one risk with a total wrist arthroplasty is loosening of the implant. if an implant is loose, revision of the implant to another twa is sometimes possible, if not, a wrist fusion is the likely alternative. revision rates five years after the index operation have improved, however, they cannot yet compare with the results after a total hip arthroplasty. a newly designed twa has been developed by the department of hand surgery, örebro university hospital, örebro, sweden, in cooperation with trimed inc. the newly developed twa offers theoretical advantages and has been biomechanically tested at the mayo clinic. this is a pilot study where patients operated with the twa will be assessed pre and postoperatively according to study protocol in order to evaluate outcome after twa radiologically, clinically and regarding patient perceived outcome measures.

method: patients will be studied preoperatively and after 1, 2, 5, and 10 years with respect to changes of the following outcome measures. 1. patient related outcome measures: dash=disabilities of arm shoulder and hand, copm=canadian occupational performance measure, prwe=patient related wrist evaluation. 2. wrist range of motion: dorsal/volar flexion, ulnar/radial deviation, pronation/supination. hand grip strength, pinch grip, key pinch. 3. wrist pain. vas-pain scores (visual analog score) at rest and in activity. 4. x-ray findings. implant survival will be studied with kaplan-meyer graphs.

Eligibility criteria:
inclusion criteria: * painful wrist arthritis * wrightington x-ray grade 2-4. exclusion criteria: * infection * substance abuse * mental illness.

Keywords: wrist arthritis total wrist arthroplasty
urine biomarkers for renal function monitoring in preterm infants

Conditions: Premature Infant

Summary: the true renal function of preterm infants is difficult to evaluate. serum creatinine (cr) levels in infants are unreliable as a detector of renal function in the first few days of life because they may continue to reflect maternal levels. although few candidates appear to be a useful biomarker for kidney injury, scant reference data on these biomarker in preterm infants exist, and studies have yielded conflicting results. therefore, we aimed to determine the reliable urinary biomarkers to detect kidney injuries in preterm infants.


Eligibility criteria:
inclusion criteria: * premature infants born before 37 weeks of gestational age exclusion criteria: * cardiac or renal anomalies * transferred in 2 days after birth from other hospitals