Kornimate/medical-research-clean huggingface dataset:
symptom care at home-heart failure

Conditions: Heart Failure; Symptoms and Signs

Summary: this project aims to adapt a computer-interface telephonic interactive voice response system that monitors symptoms and provides real-time, self-management coaching messages based on heart failure patient-reported outcomes.

keeping heart failure (hf) patients at home with a low symptom burden after hospital discharge is challenging. hf patients may suffer worsening symptoms over time without seeking medical advice leading to poor quality of life and readmission to the hospital. evidence shows that delay in hf symptom recognition and poor self-management are associated with unplanned hf-related emergency department (ed) visits and rehospitalizations. clinical trials aimed at preventing rehospitalization using telemonitoring of physical changes, such as daily weights, have shown limited utility. understanding patients' experiences of hf symptoms and engagement in appropriate self-management are key to maintaining disease stability. cancer studies have shown that symptom burden can be effectively decreased using automated home monitoring and self-management coaching. a recent cancer study has demonstrated that patients receiving cancer chemotherapy achieved a 40% reduction in symptoms using symptom care at home (sch), a telephone-computer interface interactive voice response (ivr) system pairing patient-reported symptoms with automated real-time self-management coaching. while a few hf studies have used interventions that monitored symptoms, no studies have tested a system that monitors and provides real-time self-management coaching tailored to specific patient-reported outcomes (pro). the objective of this study is to adapt the sch system to hf and conduct a pilot randomized controlled trial (rct) to assess the feasibility, acceptability, and preliminary efficacy of the symptom care at home - heart failure (sch-hf) system. participants are randomized to receive usual care consisting of automated daily monitoring, or to receive the intervention, which includes automated daily monitoring and real-time self-management coaching.

Eligibility criteria:
inclusion criteria: * medical diagnosis of heart failure * new york heart association (nyha) classification of the stages of heart failure class i - iv * ability to read, understand, and speak in english * will be discharged home * has daily access to any type of telephone exclusion criteria: * a score of 0 or 1-2 with an abnormally drawn clock on the mini-cog * discharged home on hospice care * end-stage renal failure * wait list for heart transplant

Keywords: symptom management technology
mulligan therapy effects in healthy subjects with induced vertigo

Conditions: Vertigo

Summary: this analysis aims to evaluate the immediate effect that cervical sustained natural apophyseal glides (snags) have on a group of individuals with induced vertigo by a caloric vestibular stimulation.


Eligibility criteria:
inclusion criteria: * healthy subjects, * age 18-44 years. exclusion criteria: * consume of antipsychotics, antidepressants, antiarrythmics and/or anticonvulsivants * hippoacusia * auditory diseases * peripheral or central vestibulopathies * cerviogenic dizziness * balance disorders * nistagmus * oculomotor nerve dysfunctions * migraine * cervical osteoporosis, lashing or fracture * discal cervical hernia * cervical neuropathy * psychriatic disorders * epilepsy * pregnancy
car t-cell therapy in patients with renal dysfunction

Conditions: Non-hodgkin Lymphoma,B Cell; Multiple Myeloma; Acute Lymphoblastic Leukemia, Adult

Summary: this is a prospective, descriptive study designed to assess the feasibility of administering car t therapy among patients with moderate to severe renal impairment using dose adjusted lymphodepleting chemotherapy.


Eligibility criteria:
inclusion criteria: * receiving lymphodepleting chemotherapy prior to commercial car-t administration for multiple myeloma, leukemia, or lymphoma * adequate bone marrow function to receive lymphodepleting chemotherapy * renal function \</= 60ml/min/1.73m2 * ecog 0-2 exclusion criteria: * relative cns disorders * active uncontrolled infection or any other concurrent disease or medical condition that was deemed to interfere with the conduct of the study as judged by the investigator * use of therapeutic dose systemic corticosteroids (defined as \>20mg/day prednisone or equivalent) within 72 hours of car-t administration
haemoglobin measurement for babies

Conditions: Hemoglobins; Infant; Non-invasive

Summary: in this prospective study different methods of haemoglobin measurement in term and preterm neonates are compared with the gold standard. non-invasive haemoglobin measurement with the radical-7® (sphb, masimo®), point-of-care haemoglobin-measurement (hchb, hemocue@, radiometer), blood-gas-analysis (bgahb,abl800®, radiometer) are compared with haemoglobin measurement by an automated hematology analyzer (labhb, siemens advia®).

neonates admitted to neonatal intensive care unit or to a normal neonatal ward are enrolled in the study, if parents have given their written informed consent. non-invasive sphb measurements are recorded prior to routine venous sampling. routine venous sampling includes labhb and bgahb. additionally hchb is taken from the routine venous sampling (hchbart/ven) and from an additionally capillary puncture of earlobe or heel (hchbcap). every neonate can participate in two measurements.

Eligibility criteria:
gender both age limits minimum age 3 days of life maximum age 44 postmenstrual weeks accepts no healthy volunteers inclusion criteria: written informed consent of the parents - exclusion criteria: * allergy against sensor patch * medical or psychological factors that inhibit a correct finazilation of the study
diaphragmatic breathing for the treatment of bloating and distension

Conditions: Bloating

Summary: the purpose of this study is to evaluate the efficacy of diaphragmatic breathing using the validated mayo bloating questionnaire.


Eligibility criteria:
inclusion criteria: * referred for breath testing for the indication of bloating. exclusion criteria: * not referred for breath testing for the indication of bloating.
regulation of affect and physiology in depression

Conditions: Major Depressive Disorder

Summary: although treatments for depression are effective for many people, not everyone responds to treatment. this lack of treatment response could be due, in part, to the presence of multiple underlying causes of people's depression. this study aims to identify subtypes of depression, based on two factors: how successful people perceive themselves to be at regulating their affect in everyday life; and how much activity in the parasympathetic nervous system increases during moments when people try to regulate. the study involves ambulatory assessment of affect, regulation strategies, and physiological activity in everyday life, in a sample of young adults with remitted major depressive disorder and healthy volunteers. we will study regulation responses in the lab to further determine how subtypes differ in neural, physiological, and behavioral responses. finally, participants will be randomly assigned to a remote, self-administered biofeedback intervention (vs. control intervention) designed to increase parasympathetic activity and physiological regulation success. while engaging in biofeedback at home for 10 days, participants will simultaneously repeat the ambulatory assessments. this design will allow us to determine the proximal impact of biofeedback on indices of regulation success in everyday life, and whether biofeedback has differential impact on regulation success for different subtypes.


Eligibility criteria:
inclusion criteria for participants with remitted depression: 1. age 18-27. 2. meeting criteria for lifetime major depressive disorder. 3. currently meeting criteria for full remission (absence of clinically significant symptoms) for at least eight weeks, and having a hamilton depression rating scale score of less than or equal to 7. inclusion criteria for healthy volunteer participants: 1. age 18-27. 2. no lifetime history of any psychiatric disorder. 3. no first-degree relatives with a mood disorder. exclusion criteria (same for all participants): 1. change in psychotropic medication use within the last 30 days 2. autism spectrum disorder 3. current eating disorder 4. intellectual disability 5. substance use disorder within the past 6 months 6. contraindications for magnetic resonance imaging or electrocardiogram assessment (e.g., presence of metal in body, claustrophobia, cardiac device, pregnancy).
a study of pf-04447943 compared to placebo in subjects with mild to moderate alzheimer's disease

Conditions: Alzheimer's Disease

Summary: the purpose of this study is to evaluate the effects of pf-04447943 compared to placebo on cognitive, behavioral and overall symptoms of alzheimer's disease; evaluate the safety and tolerability of pf-0444793 compared to placebo; and determine the levels of pf-04447943 in the plasma over the course of the study.


Eligibility criteria:
inclusion criteria: * mild to moderate alzheimer's disease (mmse 14-26) * good general health (such controlled conditions as type 2 diabetes and hypertension allowed) exclusion criteria: * use of acetylcholinesterase inhibitors (donepezil, rivastigmine, or galantamine) or memantine within 12 weeks of the start of the study * significant cardiovascular disease in the past 6 months * illness other than alzheimer's disease that could contribute to cognitive impairment * history of stroke or seizure disorder

Keywords: alzheimer's disease pf-04447943 efficacy safety plasma concentrations
effect of fluconazole on the levels of asca after surgical resection for crohn's disease.

Conditions: Crohn's Disease Aggravated

Summary: this was prospective study randomized in two controlled parallel groups verum versus placebo. the objectives were to assess the influence of antifungal treatment with fluconazole (fcz) on the rate of asca and endoscopic recurrence at 6 months. the rational was based on our previous research having established i) a link between intestinal inflammation and the opportunistic fungal pathogen c. albicans -a yeast colonizing the human digestive tract- ii) the demonstration that this yeast species could be at the origin of asca, a prominent serological marker of cd. it was therefore hypothesized that the fcz could lower the rate of asca and/or reduce the occurrence of recurrences.


Eligibility criteria:
inclusion criteria: 1. crohn disease patients with a small intestine localisation (ileum or ileocecal) 2. ileal or ileocecal resection in the month before inclusion (resection of all macroscopic lesions). if resection with temporary stoma, the patient may be included at the time of surgery to restore the continuity 3. patient with low risk of recurrence according to the following criteria: (i) total length of the resection(s) of the small intestine less than 100 cm (ii) segmental colectomy leaving in place at least another colonic segment as the rectum 4. preoperative rate of asca\> 70 arbitrary units (+/- 10%) 5. informed consent signed to be involved in the study exclusion criteria: 1. pregnant women or without adequate contraception 2. total length of the resection(s) of the small intestine more than 1 meter 3. subtotal colic resection 4. preoperative rate of asca\<63 arbitrary units (+/- 10%) 5. known hypersensitivity to fluconazole or other azoles 6. known liver disease or transaminase levels \>1.5 the normal rate 7. patient with renal failure 8. inability to read and sign the informed consent

Keywords: crohn disease candida asca
transpulmonary pressure in one lung ventilation and open pneumothorax

Conditions: Pneumothorax

Summary: esophageal pressure during one lung ventilation

esophageal pressure comparison during positive pressure ventilation, one lung ventilation, lateral position and open pneumothorax

Eligibility criteria:
inclusion criteria: * patients scheduled for vats requiring one lung ventilation * body mass index below 35 kg/m\^2 exclusion criteria: * esophageal pathology preventing insertion of orogatric tube * scoliosys
group-based stabilization and skill training for patients with lasting posttraumatic reactions in mental health care

Conditions: Stress Disorders, Post-Traumatic; Mental Disorders; Trauma and Stressor Related Disorders

Summary: this study evaluates the addition of a group based stabilization and skill-training intervention to individual out-patient treatment for long lasting post-traumatic reactions. half of the participants will receive the combined treatment while the other half will receive individual treatment as usual.

many patients in mental health care have previously experienced life-stressors and traumatic events that are related to the problems they seek treatment for. although the diagnostic labels vary, the clinical picture often demonstrates long lasting complex psychological and somatic post-traumatic symptoms such as avoidance, bodily activation, difficulties in regulating emotions and in relationships with others, impaired quality of life and reduced level of function. patients often receive long-term individual therapy in general mental health care, occasionally without clinically significant improvement. still, they continue treatment due to high symptom pressure and low level of functioning. the study targets a novel intervention which tests the effect of adding a group based stabilization and skill training intervention to conventional individual treatment among 160 patients already receiving treatment in a community mental health hospital. change in variables covering mental health issues, functional impairment, well-being, use of hospital services and drug prescriptions will be examined, as well as markers of inflammation found in sera before and after intervention. the purpose is to develop better and more effective treatment options for a large number of patients who receive mental health care in community mental health hospitals.

Eligibility criteria:
inclusion criteria: * receiving treatment in ordinary out-patient clinics * having been exposed to or witnessing to traumatic event(s) defined as "one or several extremely threatening or horrific events or series of events or situations being of such a character which is likely to overwhelming distress in almost anyone in a similar situation", measured by stressful life events screening questionnaire * presenting with posttraumatic reactions such as hyperarousal, avoidance, intrusions, emotional dysregulation or interpersonal difficulties. * symptom duration for a minimum of six months. * understand and speak norwegian to an extent that is required to participate in a stabilization- and skill-training group. exclusion criteria: * active psychotic symptoms. * substance or drug addiction or abuse. * high suicidal risk considered by the individual therapist. * having participated in the course previously.

Keywords: psychotherapy
pre and post arthrogram ultrasound images of joints

Conditions: Joint Abnormalities

Summary: the purpose of this study is to determine the usefulness of contrast in ultrasonography of the joints.

to determine if using intra-articular contrast (contrast injected into a joint) will provide clearer, more precise ultrasound images of the joints then an ultrasound done without the use of a contrast agent.

Eligibility criteria:
inclusion criteria: * clinically ordered arthrogram exclusion criteria: * pregnant women * children under the age of 18

Keywords: arthrogram contrast joint ultrasound
esophageal fully covered metal stents in caustic strictures study

Conditions: Refractory Benign Esophageal Strictures Caused by Caustic Ingestion

Summary: the purpose of this study is to establish clinical proof of concept of temporary indwell of the wallflex™ esophageal fully covered metal stent (fcms) for the treatment of refractory benign esophageal strictures caused by caustic ingestion.

the purpose of this study is to establish clinical proof of concept of temporary indwell of the wallflex™ esophageal fully covered metal stent (fcms) for the treatment of refractory benign esophageal strictures caused by caustic ingestion. also to collect data in support of a hypothesis required to prospectively document the safety and effectiveness of temporary indwell of the wallflex™ esophageal fully covered metal stent (fcms) compared to repeated bougie dilation for the treatment of refractory benign esophageal strictures caused by caustic ingestion.

Eligibility criteria:
inclusion criteria: 1. availability of medical history pertaining to dysphagia score prior to and during the preceding secser. 2. availability of patient history pertaining to weight prior to and at completion of secser. 3. benign esophageal stricture caused by caustic ingestion 12 or more weeks prior to enrollment. 4. single esophageal stricture or multiple esophageal stricture over a length \< 6 cm. 5. having completed the secser consisting of 3 dilations intended to reach 15 mm each, separated by 2 weeks, followed by 3 dilations intended to reach 15 mm each with steroid injections, separated by 2 weeks. the dilations may be performed using bougie or balloon dilation at the discretion of the investigator. 6. refractory stricture defined as recurrence of stricture with associated dysphagia within 6 months after completion of secser. 7. dysphagia score of 2 (ability to swallow semi-solid foods), 3 (ability to swallow liquids only) or 4 (unable to swallow liquids) at baseline. 8. unable to pass a standard endoscope (approximately 9.8 mm diameter). 9. age 18 years or older. 10. willing and able to comply with the study procedures and provide written informed consent to participate in the study. exclusion criteria: 1. stricture within 2 cm of the upper esophageal sphincter. 2. concomitant esophageal ulcerations. 3. prior esophageal stent placements. 4. concurrent gastric and/or duodenal obstruction. 5. patients with prior full or partial gastrectomy. 6. sensitivity to any components of the stent or delivery system. 7. concurrent medical condition that would affect the investigator's ability to evaluate the patient's condition or could compromise patient safety. 8. participation in a clinical trial evaluating an investigational device within 3 months prior to enrollment in this study.

Keywords: refractory benign esophageal strictures caused by caustic ingestion
symptoms ,signs and complications that appear after infection with covid 19 virus

Conditions: COVID-19

Summary: 1. raise awareness for persistent post-covid syndrome (ppcs). 2. rising tide of physical and psychological disabilities that have been described in post-covid patients.

since sars-cov-2 infection was recognised in late 2019, the academic and clinical emphasis has been on respiratory manifestations . post-covid syndrome appears to be a multisystem disease, occurring even after a relatively mild acute illness. increasing evidence exists for direct multiorgan effects, and indirect effects on other organ systems and disease processes, such as cardiovascular diseases and cancers, through changes in healthcare delivery and patient behaviors . so, the long term effects of covid-19 on individuals and health systems are becoming clear, investigation across organ systems is urgently needed. long covid, or post-covid syndrome, is not one condition, and is defined by the national institute for health and care excellence (nice) as "signs and symptoms that develop during or after an infection consistent with covid-19 which continue for more than 12 weeks and are not explained by an alternative diagnosis . nice guidelines recommend referral to post-covid syndrome assessment clinics if post covid symptoms persist for 6-12 weeks . pre-existing conditions and risk factors are predictors of acute covid-19 outcomes (such as admission to the intensive care unit and mortality, but the epidemiology of postcovid syndrome has been less well defined . because of the unclear medium and long term pathophysiology across organ systems. when post-covid syndrome clinics are established, characterization of the epidemiology of the disease will help with appropriate diagnosis, care, public health interventions and policy, and resource planning. so, further research is highly indicated.

Eligibility criteria:
inclusion criteria: * patient diagnosed as covid-19. * presence of post covid-19 symptoms. exclusion criteria: * patient refusal. * patient less than 18 years.

Keywords: post covid-19
functional effects and impact on motor neuronal activity of early and intensive motrice (hand and arm bimanual intensive therapy including lower extremities: habit-ile) reeducation in children with pre-school bilateral cerebral palsy

Conditions: Cerebral Palsy

Summary: one of the urgent priorities in the field of pediatric neuro-rehabilitation is the development of efficient early motor interventions for children with cerebral palsy (cp). animal studies suggest that early intensive interventions are likely to have a significant impact on the organization of the brain and corticospinal tracts, reducing motor impairments and their medium and long-term consequences in children with cerebral palsy. although most of the growth, development and cortical organization takes place in the time course of the first 2 years of life, most studies investigating the effectiveness of intensive rehabilitation and associated neurophysiological mechanisms have been conducted in school-aged children (\> 6 years). in addition, the vast majority of these studies were conducted in children with unilateral cp, while the bilateral form of the pathology has the highest prevalence. it is therefore a priority to investigate the effectiveness of early interventions on the overall motor function of children with cp, especially in children with bilateral form of cp. hand and arm bimanual intensive therapy including lower extremities (habit-ile) makes it possible to apply the concepts of structured motor learning and intensive treatment to both the upper limbs and the lower limbs and demonstrated improvements at both levels in school-aged children with unilateral cp and bilateral and then at all three international classification of functioning and disability levels. the principles and content of habit-ile can be applied to pre-school children and this method is promising for early neuro-rehabilitation.

the main objective of this study is to evaluate the effect of 10 days (i.e. 50 hours) of early habit-ile (habit-ile) on the overall motor function of children aged 1 to 4 with bilateral cerebral palsy in comparison to 10 days (50h) of spontaneous overall motor activity including usual rehabilitation (control group).

Eligibility criteria:
inclusion criteria: * child with bilateral cerebral palsy proven to be spastic or dyskinetic * 1 to 4 years old inclusive (12 to 59 months) (age corrected if premature) able to follow instructions and to be able to carry out all the assessments, in accordance with his age * being matched to a child according to age, etiology of cp / classification of motor function (gmfcs) * signature of consent by the two holders of parental authority exclusion criteria: * exceed 4 years and 11 months (59 months) during the internship evaluation period. * uncontrolled epilepsy. * history of toxin injection or surgery in the 6 months preceding the study period or scheduled within 3 months (during the study period). * visual or cognitive deficit preventing the child from seeing the games and interacting * usual contraindications to magnetic resonance imaging (mri) such as metal implants.

Keywords: cerebral palsy (cp) pre-school children with bilateral cp