Kornimate/medical-research-clean huggingface dataset:
dose escalation and dose expansion study of rmc-6291 monotherapy in subjects with advanced krasg12c mutant solid tumors

Conditions: Non-Small Cell Lung Cancer (NSCLC); Colorectal Cancer (CRC); Pancreatic Ductal Adenocarcinoma; Advanced Solid Tumor

Summary: the purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics (pk) of escalating doses of rmc-6291 (kras g12c(on) inhibitor) monotherapy in adult subjects with advanced solid tumors and to identify the maximum tolerated dose (mtd), and the recommended phase 2 dose.

this is an open-label, multicenter, phase 1/1b study of rmc-6291 monotherapy in subjects with advanced krasg12c-mutant solid tumors. the study will include 2 components: a dose-escalation and a dose-expansion. subjects will be treated until disease progression per recist v1.1, unacceptable toxicity, or other criteria for withdrawal are met, whichever occurs first.

Eligibility criteria:
inclusion criteria: * subject must be ≥18 years of age. * subject must have pathologically documented, locally advanced or metastatic krasg12c-mutated solid tumor malignancy (not amenable to curative surgery) that has previously been treated with standard-of-care therapies for respective tumor types, is intolerant to, or is considered ineligible for standard-of-care anticancer treatments. * ecog performance status 0 or 1 * prior treatment with a krasg12c (off) inhibitor allowed for dose escalation * adequate organ function exclusion criteria: * primary central nervous system (cns) tumors * active brain metastases * known impairment of gi function that would alter the absorption * major surgical procedures within 28 days or non-study-related minor procedures within 7 days of treatment. * prior therapy with krasg12c (on) inhibitor other inclusion/exclusion criteria may apply.

Keywords: rmc-6291 ras(on) kras krasg12c krasg12c(on) targeted therapy metastatic cancer lung cancer lung neoplasms thoracic neoplasms non-small cell lung cancer carcinoma, non-small cell lung nsclc colorectal cancer colonic neoplasms crc appendiceal cancer kras mutation stk11/lkb1 keap1 bronchial neoplasms respiratory tract neoplasms neoplasms by site neoplasms colon cancer rectal cancer lung disease respiratory tract diseases pancreatic cancer carcinoma, pancreatic ductal pdac gastrointestinal neoplasms intestinal neoplasms esophageal cancer ampullary cancer gastric cancer gynecological cancer ovarian cancer endometrial cancer
perfect project - part 2 - study 1

Conditions: Diabetes; Obesity

Summary: the objectives are to test the acute effects of different extruded pulse snacks on: 1) aerobic endurance and substrate oxidation during exercise 2) response of blood glucose, insulin and appetite on an aerobic exercise session, and 3) food intake two hours following the exercise session. the investigators hypothesize that consumption of food products containing pulse ingredients 60 minutes before exercise will increase aerobic endurance (lower oxygen consumption), decrease carbohydrate oxidation (greater respiratory quotient), and a reduction in lactate production during compared to the same exercise session following the ingestion of a non-pulse food. the investigators also hypothesize that consumption of extruded pulse snacks will lead to lower blood glucose, insulin, appetite and food intake, suggesting lower calorie compensation, following a 60-minute aerobic exercise session compared to the same exercise session following the ingestion of a non-pulse food.


Eligibility criteria:
inclusion criteria: * normoglycemic (\<5.6 mmol/l) and normotensive (systolic blood pressure \<140 mm hg and diastolic blood pressure below \< 90 mm hg) * bmi of 18.5-29.9 kg/m2 exclusion criteria: * restrained eaters * regularly skip breakfast * smokers * those who are active (organized activities or athletic training at a high intensity; ≥ 150 min per week of moderate to vigorous physical activity) * those on medications that may influence study outcomes or have experienced any gastrointestinal related health conditions/surgeries over the past year. * those unable to walk for an hour continuously

Keywords: diabetes prevention obesity prevention
study of an interposition supraciliary implant in patients with open angle glaucoma

Conditions: Glaucoma, Open-Angle

Summary: the purpose of this study is to prolong observational follow-up up to 36 months of patients already implanted with a novel interposition supraciliary implant.

19 patients with primary open angle glaucoma (poag) refractory to topical medical therapy were operated in late 2020 and a novel interposition supraciliary device implanted. these patients reached 6 months follow-up and the original study had to be interrupted. this observational study prolonges follow-up to 36 months

Eligibility criteria:
inclusion criteria: * all patients who were implanted in this center with the novel supraciliary interposition device under the scope of clinical trial nct03736655 exclusion criteria: * if cannot assist to all future follow-up visits
a multi-omics study of metastatic prostate cancer (mosmpca)

Conditions: Prostate Cancer Metastatic

Summary: the investigators plan to perform multi-omics technologies, including genomic, transcriptomic, epigenomic and proteomic methods, in patients with metastatic prostate cancer, aiming at uncovering the mechanism of the tumor progression, identifying distinct tumor subtypes and finding new treatment targets.

prostate cancer is the commonest malignancy and the second leading cause of tumor-related death among males worldwide. though patients with early stage prostate cancer can obtain satisfactory therapeutic efficacy from radical prostatectomy or radiotherapy, the prognosis of men with metastatic prostate cancer (mpca), especially metastatic castration-resistant prostate cancer (mcrpc), is still poor. recent years have witnessed the rapid development of the high-throughput technologies, including genomic, transcriptomic, epigenomic and proteomic methods. these techniques are promising in uncovering the mechanism of the tumor progression, identifying distinct tumor subtypes and finding new treatment targets. in the current prospective study, the investigators plan to perform multi-omics technologies in patients with mpca, aiming at uncovering the mechanism of the tumor progression, identifying distinct tumor subtypes and finding new treatment targets.

Eligibility criteria:
inclusion criteria: * pathological confirmation of prostate cancer * age: ≥40 years old * bone or visceral metastatic disease confirmed by image examination. * written informed consent exclusion criteria: * patients harbouring other types of cancer besides prostate cancer

Keywords: genomic sequencing transcriptome sequencing epigenetics metabonomics immunohistochemical multi-omics study
the efficacy of injectable platelet-rich fibrin in the treatment of the female stress urinary incontinence

Conditions: Urinary Incontinence; Treatment

Summary: we aimed to evaluate the efficacy of locally applied injectable platelet-rich fibrin in women with stress urinary incontinence. we searched whether there was a decrease in the severity of urinary incontinence after the injection of platelet-rich fibrin. the participants will answer questionnaires about urinary incontinence before and after the injectable platelet-rich fibrin treatment.

female patients with pure stress urinary incontinence who gave written informed consent after being informed about the study were included in the study. two tubes of venous blood samples taken from the patients were centrifuged and injectable platelet-rich fibrin was prepared. the obtained autologous material was injected into the patient within one minute after preparation, without applying a local anesthetic. the injection was given to the anterior wall of the vagina, approximately 1.5 cm below the urethral meatus, coinciding with the mid-urethral region, and the dose was applied to three adjacent points. the procedure was repeated three times at one-month intervals. before and after the procedure, iciq-sf, udi-6, and iiq-7 questionnaires were filled and the severity of urinary incontinence was recorded.

Eligibility criteria:
inclusion criteria: * the patient who has pure stress urinary incontinence exclusion criteria: * the patient who had previous surgery for stress urinary incontinence * known platelet dysfunction * anti-coagulant users * critical thrombocytopenia

Keywords: urinary stress incontinence platelet-rich fibrin questionnaire
investigation of pectoralis muscle strength in elderly with interstitial lung disease

Conditions: Interstitial Lung Disease; Idiopathic Pulmonary Fibrosis; Sarcoidosis, Pulmonary; Geriatric

Summary: interstitial lung disease (ild) is a restrictive lung disease characterized by impaired lung function, exercise limitation and skeletal muscle dysfunction. there is limited data on skeletal muscle function in ild, most of which are focused on the lower limb muscles. the aim of this study were to evaluated the change of pectoralis muscle strength and relationship of pulmonary function with pectoralis muscle strength.

this study consisted of intervention and control groups. thirty one patients with ild were included in the patient's group and 37 healthy volunteers in the control group. all participants were selected from the geriatric population. demographic and cardiopulmonary physiotherapy assessment of all participants were performed. lung function test, maximal inspiratory and expiratory pressure and pectoralis muscle strength were measured in participants of both groups. all measurements were performed once.

Eligibility criteria:
inclusion criteria: * diagnosed with ild by a multidisciplinary team according to the 2011 ats/ers guidelines for ild * aged 65-85 exclusion criteria: * uncontrolled/active cardiovascular, metabolic, systemic or cancerous disease * significant orthopedic, neurologic or musculoskeletal comorbidity that limited functional independence * no being able to cooperate * refuse to participate in the current study

Keywords: pectoralis muscle strength lung function test respiratory muscle strength horizontal adduction
efficacy study of olaparib with paclitaxel versus paclitaxel in gastric cancer patients

Conditions: Gastric Cancer

Summary: to assess the efficacy of olaparib when given in combination with paclitaxel compared with paclitaxel alone as defined by progression-free survival (pfs), in all patients with recurrent and metastatic gastric cancer who progress following first-line therapy.


Eligibility criteria:
inclusion criteria: * recurrent or metastatic gastric cancer that has progressed following first line-therapy * confirmed atm protein status by ihc archival tumour sample * at least one lesion (measurable and/or non-measurable) that can be accurately assessed by imaging (ct/mri) at baseline and follow up visits exclusion criteria: * more than one prior chemotherapy regimen for the treatment of gastric cancer in the metastatic or recurrent setting * any previous treatment with a parp inhibitor, including olaparib * patients with second primary cancer, except; adequately treated non melanoma skin cancer, curatively treated in situ cancer of the cervix, or other solid tumours curatively treated with no evidence of disease for \>5 years

Keywords: poly(adp ribose) polymerase (parp) gastric cancer olaparib parp inhibitor atm azd2281 ku0059436 homologous recombination deficiency (hrd) recurrent gastric cancer metastatic gastric cancer
cosmetology students and skin cancer

Conditions: Skin Cancer

Summary: assess the efficacy of training cosmetology students to detect suspicious skin lesions.

the incidence of melanoma is increasing the usa. the early detection of skin cancer is associated with a significant decrease in morbidity and mortality. hair professionals (cosmetologists and barbers) have an excellent opportunity to detect suspicious skin lesions on the scalp, neck, and face due to routinely looking at this area during customer visits. currently in arkansas, cosmetology schools teach students about how to recognize skin cancer on their clients. in this program, the aim was to improve the educational module for skin cancer in schools of cosmetology in arkansas. in the proposed study, the intervention training module was designed to increase the knowledge of cosmetology schools students about skin cancer will be evaluated. it was hypothesized that this educational video will educate cosmetology students and cosmetologists about how to prevent skin cancer, how to recognize a suspicious spot or mole which may be a skin cancer, and how to talk with clients about seeing a dermatologist when a suspicious spot is found. this study was a cluster-randomized controlled trial in cosmetology schools in arkansas. the institutional review board for human subjects at the university of arkansas for medical sciences determined that this study was approved as exempt and submission was not required since it was an educational intervention to improve the quality of an educational component of the existing curriculum.

Eligibility criteria:
inclusion criteria: * for schools: the school director agrees to participate and provide written consent * for students: students were eligible at the enrolled schools if they agreed in writing to participate, filled out the baseline questionnaire, and viewed the assigned video. exclusion criteria: * the school had not recently or was not currently implementing a similar program.
motor control exercises vs standard exercises in unspecific low back pain

Conditions: Low Back Pain

Summary: the purpose of the present study was to evaluate and compare the effects of motor control exercises and standard exercises in the pain, incapacity and medicine intake of subjects with unspecific low-back pain.

eighty-four subjects with unspecific low-back pain were randomly recruited for the present study. the subjects were randomly allocated into control group (who received one hour of standard physiotherapy exercises every days during ten days) or intervention group (who received one hour of control motor exercises every days during ten days). one month after finishing these ten days, patients should perform a home-based exercises program during two months (control group performed home-based standard physiotherapy exercises; intervention group performed home-based motor control exercises). pain (visual analogic scale), incapacity index (roland morris questionnaire) and medicine intake (diary) were evaluated before the intervention, one month and three months after ending the first ten days of intervention.

Eligibility criteria:
inclusion criteria: * subjects should be independent to walk * subjects should have unspecific low back pain during at least the last two months * subjects should have had at least two recidives of low back pain within the last year exclusion criteria: * subjects with concomitant pathologies that impede the performance of exercises * pregnants * subjects with oncologic pathologies * subjects with cognitive alterations that impede the understanding of the tests

Keywords: low back pain motor control joint mobilization
clinical decision support system for quality assurance in potassium-increasing drug-drug-interactions

Conditions: Hyperkalemia

Summary: to investigate the impact of reminders for serum potassium monitoring and of hyperkalemia alerts during potassium-increasing drug-drug-interactions.

the development of hyperkalemia during potassium-increasing drug-drug-interactions (ddis) is associated with (i) unknown or elevated serum potassium level at onset of treatment and (ii) insufficient monitoring of serum potassium during therapy. however, potassium-increasing ddis are frequently started despite an unknown or elevated serum potassium level, and monitoring intervals often exceed 48 hours. this study investigates the impact of reminders for serum potassium monitoring and hyperkalemia alerts. both reminders and alerts are displayed in the electronic patient chart of in-patients treated with potassium-increasing ddis.

Eligibility criteria:
inclusion criteria: * in-patients treated with concurrent potassium-increasing drugs exclusion criteria: * outpatients; in-patients on wards without computerized physician order entry (i.e. patients treated in the icu)

Keywords: drug interactions drug monitoring potassium hyperkalemia
a study of the safety and efficacy of venetoclax for participants with chronic lymphocytic leukemia (cll) used in routine clinical practice

Conditions: Cancer, Chronic Lymphocytic Leukemia (CLL)

Summary: this observational study will evaluate the safety and effectiveness of venetoclax used in routine clinical practice for participants diagnosed with chronic lymphocytic leukemia (cll).


Eligibility criteria:
inclusion criteria: * participants diagnosed with chronic lymphocytic leukemia who have been prescribed venetoclax for the first time according to the approved label * participants (and/or legal representative) who voluntarily agree to participate in this study and sign informed consent exclusion criteria: -participants with contraindications to venetoclax as listed on the approved local label

Keywords: cancer, chronic lymphocytic leukemia (cll), venetoclax
comparing relative motion splint and metacarpophalangeal joint blocking splint for trigger finger

Conditions: Trigger Finger; Stenosing Tenosynovitis

Summary: the purpose of this study is to compare the effectiveness of relative motion splint and metacarpophalangeal joint blocking splints in terms of sign and symptoms, hand function, occupational performance, and perception of splint wearability (comfort and satisfaction) after six weeks of tf management.


Eligibility criteria:
inclusion criteria: * single or multiple trigger finger * unilateral or bilateral trigger finger * neutral metacarpophalangeal joint position can be attained during passive isolated metacarpophalangeal joint extension of the affected finger exclusion criteria: * trigger thumb * steroid injection of the affected finger within last six months * a1 pulley release of the affected finger. * history of fracture, tendon injury, nerve injury, dupuytren's contracture, and other soft tissue injuries of the affected finger or adjacent fingers.

Keywords: relative motion splint metacarpophalangeal joint blocking splint
peer support intervention for patients undergoing hematopoietic stem cell transplantation

Conditions: Hematopoietic Neoplasms; Hematopoietic Malignancy

Summary: the main purpose of this study is to determine if a novel peer support intervention (stepp) is feasible among patients undergoing hematopoietic stem cell transplantation (hsct). the name of the intervention used in this research study is stepp, a peer support intervention comprised of five learning modules on psychoeducation and supportive psychotherapy strategies, tailored to the unique needs of patients undergoing hsct.

the goal of this project is to refine a peer support intervention (stepp) for patients undergoing hematopoietic stem cell transplantation (hsct) and to conduct a randomized clinical trial to test its feasibility and preliminary efficacy for improving quality of life (qol) and reducing psychological distress. participants will be randomized into one of two study groups: peer support intervention (stepp) vs. usual care. randomization means a participant is placed into a group by chance. participants will have an equal chance of being placed in either group. study procedures include screening for eligibility and questionnaires. participation in this study is expected to last about 10 weeks. it is expected that about 80 people will participate in this randomized clinical trial.

Eligibility criteria:
inclusion criteria: * adult patients (age \> 18 years) with a hematologic malignancy undergoing autologous or allogeneic hsct. * ability to comprehend, read, and respond to questions in english as stepp is only available in english. exclusion criteria: * patients undergoing hsct for benign hematologic conditions. * patients undergoing outpatient hsct. * patients with acute or unstable psychiatric or cognitive conditions which the treating clinicians believes prohibits informed consent or compliance with study procedures. * patients undergoing hsct for the second time.

Keywords: hematopoietic neoplasms hematopoietic malignancy hsct hematopoietic stem cell transplantation
randomized controlled trial of a single-session mechanism-focused intervention for suicidal thoughts and behaviors

Conditions: Suicidal Ideation; Hopelessness; Wish to Live; Wish to Die

Summary: across multiple models of suicide risk, hopelessness and perceptions of social relatedness (i.e., lack of social connection/thwarted belongingness, perceived burdensomeness) have emerged as candidate mechanisms that maintain stbs. although these mechanisms have garnered strong empirical support in predicting stbs, there has been virtually no integration with interventions aimed for individuals at acute risk for suicide. thus, the overarching goal of the present proposal is to evaluate a mechanism-focused intervention that explicitly targets two core mechanisms implicated in the maintenance of stbs: hopelessness and negative perceptions of social relatedness. given that the period immediately following hospital discharge presents the highest risk for suicide attempts and up to 70% of patients admitted for a suicide attempt do not attend their first outpatient appointment, the intervention will be evaluated on an inpatient unit. additionally, most of the extant interventions for stbs are administered across multiple sessions (i.e., 4 sessions and up to one year); however treatments of this length are unlikely to be feasible in acute care settings. fortunately, very brief suicide prevention interventions, are effective in reducing future suicide attempts and increasing the likelihood of attending follow-up treatments. additionally, single-session interventions (not suicide specific) have been shown to reduce hopelessness immediately and at a one-month follow-up. the present study is an rct comparing a novel single session mechanism focused intervention (ssmfi) for stbs to treatment-as-usual (tau) on a psychiatric inpatient unit for patients admitted for suicidal ideation or attempt. the engagement of the putative processes (hopelessness and negative perceptions of social relatedness) that maintain stbs will be assessed, along with the feasibility and acceptability of ssmfi for stbs on an inpatient psychiatric unit.


Eligibility criteria:
inclusion criteria: * admitted for care to the adult inpatient unit at good samaritan hospital * endorse suicidal ideation and/or a recent suicide attempt (i.e., "a potentially self-injurious act committed with at least some wish to die") upon intake to the unit * 18 years of age; (4) english speaking * able to provide two methods for follow-up contact (i.e., phone number, email address) in order to complete study follow-up assessment. exclusion criteria: * current manic episode * acutely psychotic * actively detoxicating from substances * the inability to comprehend the intervention