Kornimate/medical-research-clean huggingface dataset:
comparison of outcomes between intraosseous femoral and tibial injection in simultaneous bilateral total knee arthroplasty patients

Conditions: Pain, Postoperative

Summary: in patients with osteoarthritis of the knee whose pain cannot be relieved by conservative treatment, total knee arthroplasty (tka) is the operation that increases the quality of life for the patient. pain management after total knee arthroplasty tka is an important consideration to improve patient outcomes and reduce length of stay. periarticular injections of the knee are one of the techniques used to reduce pain after surgery. studies have shown that compared to other methods of pain relief, they are effective and safe. at present, no studies to compare between multimodal intraosseous femoral injection \& multimodal intraosseous tibial injection in simultaneous bilateral tka patients.


Eligibility criteria:
inclusion criteria: * patients who will undergo bilateral total knee replacement due to osteoarthritis of both knees * used of a cemented, ps design tka surgery. * able to give informed consent exclusion criteria: * revision tka * history of previous knee or hip surgery * history of allergic reaction or side effects to the drug that will be used in the experiment * underlying diseases of chronic kidney disease or chronic liver disease (child pugh b or c) * pregnancy * history of coagulopathy or abnormal blood coagulation profile(inr \>1.4 or aptt ratio \> 1.4) * history of platelet dysfunction or platelet count \< 140,0000/mm3 * history of thromboembolism * use of anticoagulants.

Keywords: total knee arthroplasty intraosseous infiltration
the effect of arm exercises on arm oedema after breast cancer surgery

Conditions: Breast Cancer Female; Breast Cancer Lymphedema

Summary: in order to prevent lymphedema after breast surgery, patients are advised to know the risk factors for lymphedema and to avoid situations that may cause lymphedema, to perform active and passive arm exercises, to evaluate the affected area for lymphedema, to perform self-care and this should be under the self-management of the patients. investigators think that this study will have a positive effect on the literature since there are no studies on risk scoring, the combined use of training and exercises to strengthen self-care skills in preventing the development of breast cancer-associated lymphedema. from this point of view, the study was planned as a randomized controlled experiment to examine the effects of preoperative lymphedema scoring and postoperative progressive upper extremity exercises on upper extremity function and self-care in women with breast cancer.


Eligibility criteria:
inclusion criteria: * female gender, * between 18-65 years old * bmi ≤30 kg/m2 * axillary lymph node dissection (removal of at least 2 lymph nodes), * no history of cancer other than breast cancer, * does not have any chronic disease (such as diabetes mellitus, hypertension, chronic obstructive pulmonary disease) that prevents exercise * no previous diagnosis of lymphedema, * not pregnant or breastfeeding during the study, * individuals who agree to participate in the study will be included in the study. exclusion criteria: * total (simple) mastectomy, * history of bilateral lymph node dissection, * lymphedema (difference \>2 cm with an intact extremity) * individuals who do not agree to participate in the study will not be included in the study.

Keywords: breast cancer lymphedema risk scoring exercise self-care
memory imaging of normal aging

Conditions: Alzheimer's Disease

Summary: the purpose of this study is to develop imaging techniques that can distinguish functional brain changes in people at high risk for dementia years prior to onset of clinical memory problems from those with normal changes of aging.

the overall goals of this project are to identify consistent patterns of variance in brain function in patients at risk for alzheimer's disease by using apoe ε4 as a marker for disease risk. the activation blood oxygen level dependency (bold) signal will be compared to both resting and activation perfusion signals to assess the variability of cerebral blood flow as it relates to the bold signal. each participant will be imaged on a 3t mri scanner while performing an associate episodic memory task. a total of 90 individuals will be recruited for this study. participants will be non-demented, right handed, adults with or without at least one apoe ε4 allele. groups will be split as follows: a) ages 25-39: non-ε4 (n=15); b) ages 25-39: +ε4 (n=15); c) ages 40-49: non-ε4 (n=15); d) ages 40-49: +ε4 (n=15);.e) ages 50-65: non-ε4: f) ages 50-65: +ε4 (n=15). these groups will be matched for mean age, mean years of education, gender distribution, as well as the presence or absence of a family history of ad in a first degree relative. there will be 2 scanning sessions for each participant. scan session #1 and scan session #2 will be acquired within 2 weeks of each other and will take approximately one hour each.

Eligibility criteria:
inclusion criteria: * right-handed exclusion criteria: * major medical illnesses * history of significant head trauma with residual cognitive deficits * other neurological or major psychiatric disorders such as schizophrenia, bipolar disorder, developmental learning disorder, and alcohol or substance abuse * mri contra-indications

Keywords: dementia brain circulation disease /disorder proneness /risk neuropathology neurophysiology aging apolipoprotein e genotype hemodynamics memory temporal lobe /cortex
a study of the safety and tolerability of a single dose administration of cvt-301 (levodopa inhalation powder)

Conditions: Parkinson's Disease

Summary: this study is a double-blind, randomized, placebo-controlled, 2-way crossover study to evaluate the safety of cvt-301 levodopa (l-dopa) when co- administered with the first daily dose of oral levodopa/carbidopa for early morning off symptoms in patients with parkinson's disease (pd).

an "off state" is defined as the time when medication is no longer providing benefit with respect to mobility, slowness, and stiffness. off episodes may be heralded by non-motor symptoms (e.g., pain, anxiety) prior to the appearance of motor symptoms.

Eligibility criteria:
inclusion criteria: * have idiopathic pd (i.e., not induced by drugs or other diseases) as defined by fulfilling steps 1 and 2 of the united kingdom (uk) brain bank criteria, diagnosed after the age of 30 years * diagnosis of parkinson's disease and motor fluctuations and early morning off symptoms * classified as stage 1 to 3 on the modified hoehn and yahr scale for staging of pd severity (in an on state) * subjects who are on a l-dopa-containing therapy, not including rytary (or equivalent), must be stable on oral l-dopa-containing therapy for at least 2 weeks prior to the screening visit with a l-dopa/decarboxylase inhibitor (ddi)-containing regimen * subjects who are on a l-dopa-containing therapy, when including rytary (or equivalent), should be on a stable dose for at least 6 weeks prior to the screening visit * the frequency of l-dopa administrations must be at least 3 times during the waking day and a total daily l-dopa dose of ≤ 1600 mg. * on a stable regimen of their standard pd medications * on a stable regimen of any blood pressure reducing medications (if applicable) for at least 30 days prior to screening * forced expiratory volume in one second (fev1) ≥60% of predicted for race, age, sex, and height and fev1/fvc (forced vital capacity) ratio ≥70% * no clinically significant abnormalities that would affect ability to complete study as determined by medical history, physical examination, electrocardiogram, clinical laboratory test results * negative drug and alcohol testing * negative pregnancy test for all women. exclusion criteria: * participated in any prior study with cvt-301 * dyskinesia of a severity that would significantly interfere with the subject's ability to participate or perform study procedures (as determined by the updrs part 4) * any contraindication to performing routine spirometry or who are unable to perform a spirometry maneuver * have a current history of symptomatic orthostatic hypotension or are treated with medications to treat orthostatic hypotension (for example droxidopa, fludrocortisone), if they have severe dysautonomia * have chronic obstructive pulmonary disease (copd), asthma, or another chronic respiratory disease within the last 5 years.
efficacy and safety study of abp 501 compared to adalimumab in subjects with moderate to severe rheumatoid arthritis

Conditions: Arthritis, Rheumatoid

Summary: the purpose of this study is to compare the effectiveness and safety of abp 501 against adalimumab (humira®) in adults with moderate to severe rheumatoid arthritis (ra) who have an inadequate response to methotrexate (mtx).


Eligibility criteria:
inclusion criteria: 1. men or women ≥ 18 and ≤ 80 years old 2. subjects must be diagnosed with rheumatoid arthritis for at least 3 months before baseline 3. active ra defined as ≥ 6 swollen joints and ≥ 6 tender joints at screening and baseline 4. subjects must be taking mtx for ≥ 12 consecutive weeks and on a stable dose of 7.5 to 25 mg/week for \> 8 weeks prior to receiving the study drug and be willing to remain on stable dose throughout the study 5. subject has no known history of active tuberculosis exclusion criteria: 1. class iv ra, felty's syndrome or history of prosthetic or native joint infection 2. major chronic inflammatory disease or connective tissue disease other than ra, with the exception of secondary sjögren's syndrome 3. prior use of 2 or more biologic therapies for ra 4. previous receipt of humira® (adalimumab) or a biosimilar of adalimumab 5. ongoing use of prohibited treatments other inclusion/exclusion criteria may apply

Keywords: arthritis rheumatoid
study to gain insights in treatment patterns and outcomes in patients with atherosclerosis prescribed to xarelto in combination with acetylsalicylic acid

Conditions: Atherosclerosis

Summary: in this study researchers want to gain more information on treatment patterns of patients treated with xarelto in combination with acetylsalicylic acid (asa). both drugs reduce the risk of blood clots via different pathways. the study will enroll adult patients suffering from coronary artery disease (narrowing or blockage of vessels that supply the heart with blood) or peripheral artery disease (narrowing or blockage of vessels that supply the legs or head with blood). the study will focus on information on when and why physicians are starting to treat patients with xarelto in addition to asa, treatment duration, reasons to discontinue treatment and previous therapies. the study will also look into treatment outcomes for patients being treated with a combination of xarelto and asa by their physicians.

the study aims to collect real-world data on treatment patterns and decision points for treatment in patients with coronary artery disease (cad) and/ or peripheral artery disease (pad) treated with rivaroxaban 2.5 mg \[twice daily\] for the prevention of major cardiovascular events in adult patients with cad at high risk of ischemic events and/ or documented pad and to describe outcomes of an antithrombotic regime based on dual pathway inhibition (vascular dose of rivaroxaban 2.5 mg \[twice daily\] plus low-dose asa \[once daily\]) across the broad range of patient risk profiles encountered in routine clinical practice.

Eligibility criteria:
inclusion criteria: * adults with diagnosis coronary artery disease (cad) or peripheral artery disease (pad). * treatment according to local marketing authorization, rivaroxaban 2.5 mg twice daily started within 4 weeks prior to enrolment. only in those countries with a marketing authorization of rivaroxaban in the acute coronary syndrome (acs) indication, also patients already on rivaroxaban treatment for acs, who are subsequently fulfilling criteria for cad, are allowed to be enrolled within 4 weeks of this decision being made. exclusion criteria: * patients who will be treated with chronic anticoagulation therapy other than rivaroxaban 2.5 mg given for cad/pad. * participation in an interventional trial.

Keywords: coronary artery disease (cad) peripheral artery disease (pad) major adverse limb events (male) major adverse cardiac events (mace) atherosclerosis atherothrombosis thrombosis embolism thromboembolism
impact of postoperative skin disinfection with chlorhexidine on bacterial colonization

Conditions: Surgical Site Infection

Summary: a double-blinded, controlled study was conducted at one county hospital in sweden. patients were randomly assigned, skin samples were collected at four times; baseline, preoperative, after intervention and after 48 hours. bacterial colonization were assessed.

method study design this was a double blinded, controlled, block-randomized intervention study with random allocation to chlorhexidine- group or sodium chloride- group. sample and setting participants was recruited at one county hospital in the southeast of sweden from august 2019 to mars 2023. consecutive sampling of adult patients over 18 years of age scheduled for primary elective shoulder arthroplasty surgery was approached for participation. intervention according to a predetermined schedule, the surgery site was either disinfected with 5 mg chlorhexidine in 70% ethanol or cleaned with sterile sodium chloride, skin samples skin swabs were collected on four occasions: 1. baseline, 2. after skin disinfection, 3. post-intervention, and 4. after 48 hours. all samples in the study were collected utilizing the eswab system with flocked swabs two swabs were collected on each occasion. the pencil eraser swab (pes)- technique was employed (26). swabs were gently rubbed in an oscillating motion, moving downward, and then replicating the same motion upward, repeated 15 times. for sample 1 and 2, one swab on each side of the intended incision site was collected. for samples 3 and 4, swabs were taken from each sides of the incision, positioned 1 cm away from the sutures or staples, with one swab collected on each side

Eligibility criteria:
inclusion criteria: adult patients over 18 years, scheduled for primary elective shoulder arthroplasty surgery. exclusion criteria: exclusion criteria were previous allergic reaction or perceived adverse effects of chlorhexidine, prolonged treatment with cortisone (\>5 mg), antibiotic treatment within 14 days prior to scheduled surgery, skin disease or ongoing skin infection. -
ciprofloxacin special drug use investigation - to investigate the safety and efficacy in patients with ciprofloxacin iv administration without dilution

Conditions: Infection

Summary: this study is a post-marketing surveillance in japan to investigate the safety especially focusing on injection site adverse events and efficacy in patients with ciprofloxacin iv administration without dilution in the daily practice.it is a local prospective and observational study of patients who have received ciproxan intravenously for sepsis, secondary skin infections followed by superficial burn, post-surgical or post-traumatic, pneumonia, peritonitis, cholecystitis, cholangitis, anthrax. a total of 500 patients are to be enrolled and assessed during the period of treatment with ciproxan.


Eligibility criteria:
inclusion criteria: * - the mentioned bellow patients caused by the following bacteria which are sensitive to this drug: indicated microorganisms:staphylococcus, enterococcus, bacillus anthracis, escherichia coli, klebsiella , enterobacter, pseudomonas aeruginosa, legionella. indications: sepsis, secondary skin infections (superficial burn, operative wounds, trauma), pneumonia, peritonitis, cholecystitis, cholangitis, anthrax * the patients treated with this drug without dilution due to strict restriction of fluid intake. * in hospitalized patients who retain consciousness ,and at the same time who are able to report (such as vascular pain) side effects.. exclusion criteria: * patients who are contraindicated based on the product label.

Keywords: ciprofloxacin sepsis infection pneumonia peritonitis cholecystitis cholangitis anthrax
effect of transcranial direct current stimulation on peripheral neuropathy

Conditions: Peripheral Neuropathy

Summary: this study will be performed in patients with peripheral neuropathy who are walking independently, but have complains of balance problems such as recent falls or difficulty walking and show reduced vibratory and proprioceptive sensation during routine neurologic examination. these patients will be tested for proprioceptive and vibratory threshold at the toes and ankles before, during and after receiving anodal direct transcranial cortical stimulation (dtcs) over sensory and motor cortices. subjects will be asked to participate in 2 sessions.

this study will be performed in patients with peripheral neuropathy who are walking independently, but have complains of balance problems such as recent falls or difficulty walking and show reduced vibratory and proprioceptive sensation during routine neurologic examination. these patients will be tested for proprioceptive and vibratory threshold at the toes and ankles before, during and after receiving anodal transcranial direct current stimulation (tdcs) over sensory and motor cortices. subjects will be asked to participate in 2 sessions. in one of the sessions, decided randomly, the stimulation will be applied on the right side and in the second session it will be on the left. the tdcs portion of the experiment will begins with direct current (maximum of 2 ma) stimulation delivered through surface electrodes (transqe from iomed®, surface area: 25 cm2) using a phoresor® ii auto (model no. pm850, iomed®, salt lake city, utah 84120, usa). one electrode will be positioned above the left or right primary motor cortex, the other electrode over the forehead.

Eligibility criteria:
inclusion criteria: * peripheral neuropathy * walking independently but with problems with balance exclusion criteria: * prominent weakness at the ankle * not able to walk independently * history of seizure * cardiac pacemaker * metal implants in the head * increased intracranial pressure * pregnancy
emdr vs. pc for motor vehicle accident trauma

Conditions: Trauma, Psychological; Motor Vehicle Accident

Summary: this is a randomized clinical trial comparing eye movement desensitization and reprocessing (emdr) to progressive counting (pc) for volunteers from the community who are distressed by the memory of a motor vehicle accident. participants will be assigned to the geographically nearest therapist, and then randomized to treatment condition.


Eligibility criteria:
inclusion criteria: * adult reporting distress related to motor vehicle accident-related trauma * english-speaking exclusion criteria: * already in therapy in which the memory of interest is being actively addressed with a structured/focused trauma resolution method * any obvious/urgent need for more comprehensive psychotherapy (based on initial screening interview) * any indication of instability during interactions prior to the therapy session * an average score on the dissociative experiences scale of 30 or greater, if (as per follow-up questions) indicating a likely dissociative disorder
balance performance and corticomotor inhibition in pd

Conditions: Parkinson Disease

Summary: postural instability is one of the motor features of parkinson's disease (pd). most patients will develop balance dysfunction, and they may get worse with disease progression. according to previous studies, people with pd had abnormal changes in corticomotor excitability, especially disinhibition in the primary motor cortex (m1). some evidence had shown that the cortical function in the m1 is crucial for the pathophysiology of the underlying motor symptoms in pd. furthermore, neurostimulation over the m1 could modulate the corticomotor excitability in individuals with pd, and then improve their motor and also balance performance. however, whether the impaired corticomotor inhibition relates to balance dysfunction in people with pd is still unknown. in this study, the purpose is to investigate the possible relationship between corticomotor inhibition and balance performance in individuals with pd. however, the postural position during tms measurement may affect the corticomotor excitability. to further establish the above-mentioned relationship, the secondary purpose is to explore and confirm whether the postural position will influence the correlation.


Eligibility criteria:
inclusion criteria: * the hoehn and yahr stage between 1 and 3 * age 40 to 80 years * a stable treatment of anti-pd medications exclusion criteria: * any contraindications of tms * any injury histories or disorders affecting balance * any neurosurgery experience * neurologic conditions other than pd * the mini-mental state examination (mmse) score \< 24

Keywords: parkinson's disease; transcranial magnetic stimulation; motor cortex; corticomotor inhibition; balance performance
disconnection and unilateral spatial neglect

Conditions: Stroke

Summary: retrospective cohort study of consecutive patients investigated in a neurorehabilitation ward after a first hemispheric stroke. unilateral spatial neglect (usn) and other cognitive impairments (including attention, executive functions, memory) have been assessed in routine care at the subacute phase (\<6 months). mri scans have also been done in routine care. the study aims at linking lesion characteristics, disconnections induced and expression of the different modalities of usn


Eligibility criteria:
inclusion criteria: * first hemispheric adult stroke patient * non-opposed to inclusion * confirmed by mri * assessment of cognitive functions during the subacute phase (3 weeks to 6 months after stroke onset exclusion criteria: * history of previous stroke or neurological disorders * inability to perform cognitive assessment due to severe comprehension, cognitive or psychiatric disorder * uncorrected severe loss of visual acuity * contra-indications to mri

Keywords: stroke unilateral spatial neglect mri disconnectome, cognition
fractional laser and steroid ointment to improve the old scar after thyroidectomy

Conditions: Thyroid; Wound; Steroid Acne

Summary: this clinical study was conducted to assess the effects of ladd combined with a fractional ablative carbon dioxide laser and a topical steroid for the treatment of post-thyroidectomy hypertrophic scars.

thyroidectomy results in unsightly scarring at the anterior neck of the patient. a clinical study was conducted to assess the effectiveness of five courses, applied every 4 weeks, of laser-assisted drug delivery (ladd) combining a fractional ablative carbon dioxide laser and topical 0.05% clobetasol propionate to the treatment of post-thyroidectomy hypertrophic scars in patients. assessments of the scars by the patient themselves according to the patient and observer scar assessment scale.

Eligibility criteria:
inclusion criteria: * patients had presented a persistent hypertrophic scar at the neck region for more than 1 year after their thyroidectomy. exclusion criteria: * systemic chronic disease or a history of autoimmune disease or human immunodeficiency virus infections.