Kornimate/medical-research-clean huggingface dataset:
management of oxaliplatin-related gastroesophageal variceal bleeding

Conditions: Gastroesophageal Varices Hemorrhage; Gastrointestinal Cancer; Received Oxaliplatin-based Chemotherapy

Summary: in this randomized controlled study, we aim to compare the efficacy and safety of these two interventions in patients with oxaliplatin-induced gastroesophageal variceal bleeding.

oxaliplatin is used as the first-line chemotherapy for colorectal cancer. however, oxaliplatin-induced hepatotoxicity could lead to sinusoidal injury and portal hypertension in the long term. variceal bleeding, as the most common complication of portal hypertension, threaten these patents' life. endoscopic treatment and transjugular intrahepatic portosystemic shunt (tips) are both recommended management of gastroesophageal variceal bleeding. in this randomized controlled study, we aim to compare the efficacy and safety of these two interventions in patients with oxaliplatin-induced gastroesophageal variceal bleeding.

Eligibility criteria:
inclusion criteria: 1. having received oxaliplatin-based chemotherapy for at least one cycle 2. history of variceal bleeding (including hematemesis or melena) 3. portal hypertension confirmed by ct or mri 4. esophageal and / or gastric varices confirmed by endoscopy 5. informed consent signed exclusion criteria: 1. with serious life-threatening diseases of circulation / blood / respiratory system 2. with known causes of liver cirrhosis (hepatitis b, hepatitis c, autoimmune, schistosomiasis, non-alcoholic fatty liver disease, and etc.) 3. with contraindications of endoscopic treatments and tips; 4. participation refused

Keywords: portal hypertension gastrointestinal cancer oxaliplatin gastroesophageal variceal bleeding endoscopic treatment transjugular intrahepatic portosystemic shunt
pharmacogenomic study to predict neurotoxicity of oxaliplatin

Conditions: Curatively Resected Stage III Colon Cancer

Summary: in order to explore genetic factors that may determine the neurotoxicity of oxaliplatin-based chemotherapy, germinal gene polymorphisms will be analyzed.

to investigate the impact of single nucleotide (snp) polymorphism on the toxicity profile in colorectal cancer patients treated with folfox chemotherapy, 10 cc of blood will be drawn in edta tube for extraction. dna will be extracted from peripheral blood samples using dna isolation kit, and snp polymorphisms will be evaluated.

Eligibility criteria:
inclusion criteria: * aged 18 or older * curatively resected colon adenocarcinoma * pathologically staged iii * adequate performance status * adequate major organ functions * to be treated with adjuvant folfox chemotherapy * written informed consent exclusion criteria: * those who disagree the study

Keywords: oxaliplatin neuropathy snps
reactogenicity and protectivity following measles- rubella (mr) routine immunization in indonesian infants and children

Conditions: Safety Issues; Immunogenicity

Summary: to assess safety and immunogenicity of measles-rubella (mr) routine immunization in indonesian children and infants

* to asses serious immediate systemic events, * to assess local and systemic reaction after measles-rubella (mr) vaccine in infants and children, * to evaluate protectivity and antibody response to measles and rubella after 1 dose of mr vaccine

Eligibility criteria:
inclusion criteria: * healthy infants (9-12 months) or children (18-47 months) * will receive mr routine immunization. * parents have been informed properly regarding the study and signed the informed consent form. * parents will commit themselves to comply with the instructions of the investigator and the schedule of the trial. exclusion criteria: * mr vaccine given simultaneously with other vaccination, except pentabio (dtp/hb/hib)

Keywords: measles-rubella vaccine safety immunogenicity reactogenicity protectivity
effects of pilates exercises and neural dynamic mobilization in sciatica patients

Conditions: Sciatica

Summary: the main purpose of the study is to find the effects of pilates exercises and neural mobilization techniques on pain, flexibility and quality of life in sciatica patients. it will be a randomized controlled trial in which participants selected through non probability convenience sampling, to evaluate the effect of 6-week pilates exercises versus neural dynamic mobilization techniques on pain, flexibility and quality of life in sciatica patients. patients aged range from 18 to 65 years. the data will be collected from service hospital lahore. patients will have diagnosed with sciatica low back pain radiating down hip to knee, numbness, paresthesia and with positive slr will include in this study whereas patients with considerable musculoskeletal deformity, previous hip, knee and ankle surgery and foot ulceration will be excluded from study .the participants will be randomly allocated to one of the two groups. group a will perform pilates mats exercises 30 minutes, two times a week and the group b will perform neural dynamic mobilization for 15 minutes, two times a week, for 6-weeks respectively. pain will be assessed by using bpfs, flexibility with canadian sit to reach test and qol with sf-36 questionnaire. spss software will be used for data entry and analysis.


Eligibility criteria:
inclusion criteria: * o participants age ranged from 18 to 65 years old * both genders. * history of nonspecific low back * lower extremity symptoms such as tingling, dull aches or burning sensation. exclusion criteria: * o significant musculoskeletal deformity such as fracture, amputation. * prior history of knee or back surgery * lower extremity arthritis that limits standing and any inflammatory disease * history of cardiovascular issues such as angina, mi * symptomatic postural hypotension * foot ulceration. * skin problems such as rashes etc.

Keywords: neurodynamic mobilization
reproductive outcomes of different sperm selection techniques for icsi patients with abnormal sperm dna fragmentation.

Conditions: Infertility, Male

Summary: comparing the reproductive outcomes of different sperm selection techniques; density gradient centrifugation (dgc), testicular sperm (testi), physiological icsi (picsi), and magnetic activated cell sorting (macs) in abnormal sperm dna fragmentation (sdf) icsi patients.


Eligibility criteria:
inclusion criteria: * female age was ≤37 years * female should has 5≥ metaphase ii oocytes * males having abnormal sdf levels ≥ 20.3% by tunel assay * abstinence from 1 to 2 days * males having at least 1 million total motile progressive count exclusion criteria: * leukocytospermia * presence of varicocele. * known genetic abnormality * use of sperm donation or cryopreserved sperm * use of oocyte donation * use of gestational carrier * presence of any of the endometrial factors that affect embryo implantation such as hydrosalpings, adenomyosis or previous uterine infection * any contradictions to undergoing in vitro fertilization or gonadotropin stimulation

Keywords: sperm dna fragmentation picsi macs sperm selection dgc
outcome of patients treated with ecls

Conditions: Cardiogenic Shock; Cardiac Arrest; Heart Failure; Acute Respiratory Failure; Acute Respiratory Distress Syndrome

Summary: extracorporeal life support (ecls), also called extracorporeal membrane oxygenation (ecmo), is an extracorporeal technique of providing effective circulatory and (or) respiratory failure, with a growing number of critically ill patients benefit from it. the aim of this study is to investigate the outcome of patients treated with ecmo, and to evaluate the short-term and long-term outcomes of patients with ecls.


Eligibility criteria:
inclusion criteria: * patients receiving ecmo for circulatory and/or respiratory support exclusion criteria: * refusal of consent
prehabilitation to improve cancer surgery outcomes

Conditions: Gastrointestinal Cancer; Prehabilitation; Surgery; Physical Activity

Summary: this is a randomized control trial aiming to investigate the use of a prehabilitation regimen for patients undergoing major gi cancer surgery and its effects on measurements of hrqol, los, and post-operative complications. participants will be randomized to either the prehabilitation arm or the usual care arm (control group). the prehabilitation arm will be prescribed both physical and psychological prehabilitation prior to undergoing surgery for their gi cancer. the usual care arm will be counseled to continue their current level of activity and given the information on exercise as outlined in the cancer care ontario guidelines. participants in the usual care arm will also be given the same activity tracker as patients in the prehabilitation arm in order to eliminate the activity tracker as an intervention itself. clinical, patient-reported outcomes and health system outcomes will be evaluated. outcomes will be measured at consent (baseline), immediately preoperatively, and postoperatively at 1, 3 and 6 months. the investigators will collect measures of recruitment, attrition and self-reported compliance via a log completed by the coordinator during weekly patient phone calls.


Eligibility criteria:
inclusion criteria: * ≥ 18 years of age * fluent in english * able to comply with study procedures \& follow-up contained within the consent form * pathologically or radiologically confirmed diagnosis of a gi cancer * gi cancer must be considered operable * expected los ≥ 5 days as calculated by the validated american college of surgeons surgical risk calculator * \> 21 days between time of randomization and time of expected surgery * patient written, informed consent obtained according to ich gcp guidelines and local regulations exclusion criteria: * \< 18 years old * not fluent in english * planned resection of bony pelvis, limbs, or major lower extremity neurovascular structures * significant comorbidity including any of the following: * canadian cardiovascular society class iii/iv coronary disease * new york heart association class iii/iv congestive heart failure * neurologic or musculoskeletal disorder prohibiting exercise * major neuropsychiatric disorder

Keywords: prehabilitation gastrointestinal cancer physical activity exercise surgery
theca cell function in women with polycystic ovary syndrome (pcos)

Conditions: Polycystic Ovary Syndrome

Summary: the mechanism for increased androgen production in women with polycystic ovary syndrome (pcos) is not well understood. excess androgen production by the ovary is stimulated by increased pituitary luteinizing hormone (lh) secretion in this disorder. the investigators hypothesize that in pcos women ovarian theca cells, which are responsible for androgen synthesis, are more sensitive to lh stimulation compared to that of theca cells from normal women. to test this hypothesis, the investigators propose to conduct a dose-response study in which androgen responses to multiple doses of human chorionic gonadotgropin (hcg), an lh surrogate, will be assessed in pcos and normal women.

each subject (normal and pcos women) will be admitted to the ucsd general clinical research center (gcrc) for study on 5 occasions. all subjects will receive an intravenous injection of hcg dose of 1, 10, 25, 100, and 250 micrograms, each of which will be given on one of 5 different days each separated by at least two weeks at 8 am. blood samples will be obtained at t -0.5, 0, and 24 hours after injection. all visits to the gcrc will be done as out patients. the total amount of blood withdrawn will be about 35 teaspoons. for normal control subjects this will be over a period of about 4-6 months and for pcos subjects this will be over a period of about 6-10 weeks.

Eligibility criteria:
inclusion criteria: * normal cbc (hemoglobin must be at least 11mg/dl) * normal renal and liver function tests * normal vital signs including normal blood pressure exclusion criteria: * no oral contraceptives * no insulin lowering drugs * no anti-androgens (i.e., spironolactone, flutamide, finasteride, etc) * no medications that will influence androgen metabolism or clearance * no medications that will inhibit the cytochrome p450 enzyme system (cimetidine, ketoconozole, etc) * no use of clomiphene citrate within 3 months prior to study

Keywords: polycystic ovary syndrome androgens ovary lh
multiparametric assessment to investigate prognostic factors for disease evolution a nd evolutionary patterns of cognitive status in rrms

Conditions: Multiple Sclerosis, Relapsing-Remitting

Summary: this prospective study combining non conventional mri techniques, neuropsychological screening tools, and a neurophysiological work-up using a sensitive and validated battery, will evaluate the predictive value of these measures and will explore the changes of the cognitive scores from baseline.

neurologists are in need for reliable and robust predictive factors enabling to predict disease evolution and treatment response. moreover, recent studies suggested that the evolution patterns of cognitive status in ms could be mixed, contradicting the concept that cognitive impairment in ms will inevitably increase over time. the main aim of this prospective study is to investigate the predictors of disease evolution, as measured by the edss score, using a multiparametric assessment combining neuropsychological tests (bccogsep battery), mri-derived metrics (volumetric brain parameters, tractography, diffusion tensor imaging and fiber tracking), patient-reported outcome measures, and neurophysiological tools (multimodal evoked potentials), and to explore the evolutionary patterns of cognitive status (changes from baseline). the investigators planned to include 50 patients with active rrms and initiating a new disease-modifying treatment. yearly assessment starting from study inclusion will be performed.

Eligibility criteria:
inclusion criteria: * active ms, according to the lublin criteria * disease duration \< 10 years before initiating or changing a disease-modifying therapies, * relapse- and steroid-free for at least 1 month before mri acquisition * between 18-50 years old * having given informed consent * with no significant comorbidity other than ms or substance abuse that could interfere with cognitive performances exclusion criteria: * progressive forms of ms

Keywords: mri evoked potentials cognitive function proms
music therapy during botulinum injections

Conditions: Cerebral Palsy

Summary: the primary objectives for this study are: 1. to demonstrate that music therapy can be an effective means of procedural support for children undergoing botox injections. 2. to explore patient, parent and healthcare personnel satisfaction with music therapy as procedural support. 3. to assess the influence of music therapy on physiologic (blood pressure, oxygen saturation, heart rate) and emotional (crying time) responses of patients.

many children with spastic cerebral palsy and other types of muscle dystonia are injected with botulinum toxin a (botox) to reduce pathological reflexes and improve muscle function. such treatment requires injections to each affected muscle group, which can be both painful and distressing. music therapy has been shown to reduce pain and decrease stress and anxiety for pediatric patients undergoing other types of medical procedures. the goal of this study is to determine whether music therapy can be effectively integrated as a means of procedural support during botox injections. this study investigates the efficacy of music therapy in reducing manifestations of pain during botox injections. secondary benefits may include increased satisfaction among medical personnel and parents. patients between the ages of 2-17 being treated with botox were eligible for enrollment. prior to the start of this study, patients had the option of receiving music therapy support during their botox injections; these subjects continued to receive music therapy upon enrolling in the study. subjects who had not previously received music therapy were videotaped for two botox sessions before having a music therapy intervention. the percentage of crying time during the procedure was calculated from videotapes taken during the sessions. surveys were given to parent/guardians and the healthcare provider performing the procedure to provide feedback on the effectiveness of the music intervention for the child and themselves. comparing average crying times for 44 children's first study visit with or without music therapy shows that children who receive music therapy cry less than children who do not, although the difference is not statistically significant. both parent and healthcare provider surveys indicate a high level of satisfaction with the music therapy intervention. the current data indicate that music therapy may be a highly effective means of procedural support, but strong conclusions cannot be drawn without more data.

Eligibility criteria:
inclusion criteria: * treatment for diplegic or hemiplegic cerebral palsy or muscle spasticity resulting from brain injury, with botulinum toxin injections. exclusion criteria: * none

Keywords: botulinum toxin music therapy cerebral palsy procedural support
phytoserms for menopause symptoms and age-associated memory decline

Conditions: Hot Flashes; Memory Loss

Summary: the purpose of this study is to evaluate the safety and efficacy of a soy based dietary supplement (phytoserm) for hot flashes and age associated memory loss.


Eligibility criteria:
inclusion criteria: * post-menopausal women * ages 45 - 60 (inclusive) * must have a vasomotor symptom (e.g., hot flash) and a memory complaint exclusion criteria: * history of clinically significant stroke * current evidence or history in past 2 years of epilepsy, seizure, focal brain lesion, head injury with loss of consciousness or any major psychiatric disorder including psychosis, major depression, bipolar disorder, alcohol or substance abuse * known allergy to soy derived products; hypersensitivity to estrogens or progestins
evaluation of v/q mismatch as predictor of pulmonary postoperative complications in patients undergoing major surgery

Conditions: Anesthesia; Postoperative Complications; Mechanical Ventilation Complication

Summary: pulmonary postoperative complications (ppc) are among the main causes of surgical complications affecting both postoperative morbidity and mortality. little is known about the effect of intraoperative vq mismatch on the occurrence of ppc. in this trial the investigators will evaluate if intraoperative vq mismatch may predict ppc in a population of patients undergoing major surgery.

pulmonary postoperative complications (ppc) are among the main causes of surgical complications affecting both postoperative morbidity and mortality. little is known about the effect of intraoperative vq mismatch on the occurrence of ppc. ppc are classically considered associated to the occurrence of intraoperative atelectasis, and therefore to the development of a certain amount of shunt, but this concept have been recently questioned. recent studies showed indeed that, despite age is one of the main determinants of ppcs, increasing age is not associated to the increase of intraoperative shunt. shunt therefore may not be the main determinant of ppc. in this trial the investigators will evaluate if other causes of intraoperative vq mismatch (e.g. low v/q, high v/q, dead space) may predict ppc in a population of patients undergoing major surgery.

Eligibility criteria:
inclusion criteria: * age 18-90 years * major elective surgery with general anesthesia * intraoperative cannulation of the radial artery for invasive pressure monitoring exclusion criteria: * thoracic surgery with one lung ventilation * refuse to participate * emergency surgery

Keywords: anesthesia pulmonary postoperative complications alpe ventilation/perfusion mismatch
a retrospective study to investigate prevalence of capsular bag distention syndrome and its influencing factors

Conditions: Capsular Bag Distention Syndrome After Cataract Surgery

Summary: * to investigate the prevalence of capsular bag distention syndrome * to analyze influencing factors of capsular bag distention syndrome


Eligibility criteria:
inclusion criteria: * patients who underwent uneventful phacoemulsification and posterior-chamber iol implantation at the eye and ent hospital of fudan university, xuhui, shanghai, china, between november 2011 and december 2012 exclusion criteria: * patients with traumatic cataracts or zonular weakness were excluded from the study, as were eyes with intraoperative complications, such as a posterior capsule opening, radial tearing of the continuous curvilinear capsulorhexis (ccc), or inappropriate iol implantation.
lingual keratinized tissue in fully edentulous patients and its impact on implant health

Conditions: Peri-Implantitis; Peri-implant Mucositis; Recession, Gingival

Summary: cross-sectional study involving the measurement of the width of lingual keratinized tissue (in the implant locations) in fully edentulous patients restored with dental implants. the width of kt will be correlated with the primary outcome, diagnosis of peri-implantitis, defined as probing depth (ppd)\>= 6 mm, inflammation/ bleeding on probing (bop) and bone loss \>= 3 mm from the implant platform.

the study will be conducted with a cross-sectional design. all clinical parameters (width of buccal and lingual keratinized tissue, probing depth, bleeding on probing, plaque, crestal bone loss, gingival index, suppuration) will be collected in mandibular implants in fully edentulous lower arches. the width of lingual band of keratinized tissue (kt) will be be correlated with diagnosis of peri-implantitis or peri-implant mucositis.

Eligibility criteria:
inclusion criteria: * osseointegrated (non-mobile) and loaded dental implant * mandibular implants * full-arch implant-supported prostheses * removable full-arch prostheses * fixed full-arch prostheses exclusion criteria: * implants loaded less than 12 months before examination * mobile (non integrated) implants * partially edentulous patients