Kornimate/medical-research-clean huggingface dataset:
effect of implementing snap-needle therapy combined with ginger paste during anesthesia recovery on the recovery of gastrointestinal function after gynecologic laparoscopy

Conditions: Gastrointestinal Motility; Postoperative Nausea and Vomiting

Summary: the aim of this study was to investigate the effect of implementing snap-needle therapy combined with ginger paste during anesthesia recovery on the recovery of gastrointestinal function after gynecological laparoscopy.


Eligibility criteria:
inclusion criteria: 1. asa i or ii; 2. performing gynecologic laparoscopic procedures under general anesthesia; exclusion criteria: 1. age ≤ 18 or ≥65; 2. the patient has a previous history of ponv, digestive disorders, etc; 3. ulcers, infections, and skin tears at acupressure and acupuncture (snap-needle) treatment sites; 4. patients allergic to ginger； 5. inability to follow protocol or refusal to participant

Keywords: gastrointestinal motility recovery of function ponv
pet/ct evaluation of primary and metastatic brain tumors with a novel radioiodinated phospholipid ether analogue i-nm404

Conditions: Glioblastoma Multiforme; Brain Metastases

Summary: the purpose of this study is to evaluate diagnostic imaging techniques using 124i-nm404 pet/ct in human brain tumors. this goal will be accomplished by quantifying tumor uptake and determining the optimal pet/ct protocol, comparing pet tumor uptake to mri, and calculating tumor dosimetry. the long-term goals of this research are to improve the diagnosis and treatment of malignant brain tumors by using radioiodinated nm404


Eligibility criteria:
inclusion criteria: * participants will have a contrast enhanced brain mri which documents evidence of primary or metastatic brain tumor or suspected tumor recurrence after therapy * tumor size at least 1.5 cm in greatest axial dimension on mri. mri must be obtained within 2 months of study inclusion * adult patients 18 or older * female patients must not be pregnant or breast feeding and both women of childbearing potential, and men, must use appropriate means of contraception and must be maintained for at least 45 days after injection of 124i-nm404 participants must not attempt to become pregnant during this time * platelet count must be ≥ 160,000/µl, hematocrit must be ≥ 22%, leukocyte count must be ≥ 3,000/µl, creatinine must be ≤ 2.5 mg/dl, alt must be ≤ 130 u/l, ast must be ≤ 100 u/l, and urine or serum pregnancy test must be negative for pregnancy * patient provides informed consent * karnofsky score ≥ 60 * for previously treated brain tumors, targeted brain therapy (radiation or drug) must have concluded ≥2 months prior to injection of 124i-nm404 exclusion criteria: * life expectancy of \< 3 months * allergy to potassium iodide (sski or thyroshield) * unwilling or unable to complete 3 separate pet/ct imaging sessions of 90 minutes each over 3 days * pregnancy or breast-feeding during time of study and/or anticipated breast feeding at any time for 45 days after injection of 124i-nm404.
clinical impact of autonomic modulation after pulmonary vein isolation

Conditions: Atrial Fibrillation

Summary: pulmonary vein isolation (pvi) has become a standard therapy for atrial fibrillation (af), however, there is still considerable af recurrence after pvi. except for pv-left atrium (la) reconnection, the cause of recurrence has been not yet fully clarified. the alternation of autonomic tone plays an important role in initiation of paroxysmal af. it was reported that there are multiple gangliated plexus (gp) around pulmonary veins, therefore the modulation targeting those gps, resulting in modulations of cardiac autonomic tone, have been conducted. some study showed the efficacy of gp ablation for af patients. according to the previous reports, heart rate (hr) increased, and heart rate variability (hrv) reduced after pvi. these are considered to be due to "autonomic denervation" caused by catheter ablation of gp. for the best of investigators knowledge, there have been no data on heart rate turbulence (hrt) of baroreflex sensitivity (brs) concerning pvi.


Eligibility criteria:
inclusion criteria: * patients who undergo pvi for paroxysmal atrial fibrillation * patients in sinus rhythm at baseline exclusion criteria: * prior left atrial ablation * left atrial diameter \>55mm * frequent atrial extrasystole, frequent ventricular extrasystole * diabetes mellitus * sleep apnea syndrome

Keywords: atrial fibrillation pulmonary vein isolation heart rate turbulence baroreflex sensitivity
mepolizumab: real world evidence study for the treatment of severe eosinophilic asthma in greece

Conditions: Severe Eosinophilic Asthma

Summary: a prospective multi-centre, non-interventional observational study, that will be conducted in several centers in greece for a 2-year time period (completion date december 2020), to describe patient characteristics, medical history, and the clinical benefit of mepolizumab in patients with severe eosinophilic asthma newly initiated to the drug.


Eligibility criteria:
inclusion criteria: * patients with uncontrolled severe eosinophilic asthma placed under treatment with mepolizumab, i.e. in patients with peripheral blood eosinophils ≥300 cells/μl at any measurement in the previous year or ≥150 cells/μl in a recent measurement, with poor symptom control and increased number of exacerbations (2 or more) despite optimal treatment with high doses of inhaled corticosteroids and β2 stimulants exclusion criteria: * patient refusal to participate in the study

Keywords: severe eosinophilic asthma mepolizumab anti-il5 treatment
avenovatm as a sterile skin preparation agent

Conditions: Cleaning Product Causing Toxic Effect

Summary: aim 1: to determine in vivo capability of avenovatm against common cutaneous microbial biome on human skin aim 2: to compare to povidone-iodine 5% solution, 4% chlorhexidine and isopropyl alcohol against avenovatm as a sterile skin agent

a total of approximately 30 eligible participants will be identified with clinically-acquired information by dr. wendy lee, an oculoplastic surgeon and aesthetic treatment specialist at bascom palmer eye institute, during regular clinic visits. part one: patients will have their skin swabbed and then cultured for various skin flora agents. the petri dish will then be swabbed with avenova to see what percent of skin flora microbe is killed. part two: patients will have their skin divided into 4 quadrants. the area will be pre-swabbed to monitor microbe growth. each of 4 quadrants will be cleansed for one minute with avenovatm , povidone-iodine 5% solution, 4% chlorhexidine and isopropyl alcohol, then swabbed to monitor for microbe growth. the swabs will be placed in thioglycollate broth to monitor for bacterial growth. if growth if observed in the thioglycollate, the samples will be cultured on blood agar plates and the bacterial specie(s) identified.

Eligibility criteria:
inclusion criteria: * adults age 18 and above able to provide informed consent to participate adults attending dr. wendy lee oculoplastics clinic exclusion criteria: * adults unable to consent * individuals who less than 18 years of age * prisoners * pregnant women - while these cleansing agents are used on pregnant women as standard cleansing agents, effects to fetus unknown * patients currently using oral or topical antimicrobial agents * history of skin infection to facial injectable of surgery * inability to tolerate cleansing procedure * inability to sit comfortably for 15 - 30 minutes
eficacy of long-term suplementation with docosahexaenoic acid in patients with cystic fibrosis

Conditions: Cystic Fibrosis

Summary: cystic fibrosis (cf) is a congenital disease secondary to the abnormal function of cftr. patients with cf have an alteration of essential fatty acids, arachidonic acid (aa) is increased and docosahexanoic acid (dha) is decrease and the ratio ω-6/ ω-3 is elevated, all these alterations stimulated a chronic and bad regulated state of inflammation. for this porpoise, a fase iv trial, multicentric, controlled, double blind, placebo and parallel in patients elder than two months old and randomized to received every day a dietetically supplement with dha or placebo, will be done during 12 months. the trial has as a principal objective to proved if this long term supplementation could decrease in contrast with placebo.


Eligibility criteria:
inclusion criteria: * diagnosed of cystic fibrosis over than 2 months age * tolerance clinical supplementation with dha * clinical situation stable exclusion criteria: * changes in the routine treatment in the 2 weeks prior to baseline * admission to hospital or administration of oral or intravenous antibiotics within 2 weeks before inclusion
mini-laparotomy versus mini lumbotomy

Conditions: Abdominal Aortic Aneurysms; Abdominal Aortic Thrombosis

Summary: this study aims to compare the results of two mini invasive surgical approaches in abdominal aortic surgery: mini lumbotomy with retroperitoneal approach versus mini laparotomy with transperitoneal approach. respiratory and renal functions and recovery of intestinal transit will be assessed after 30 days. the secondary purpose of this study is to assess the life quality and morbi-mortality at 30 days, as well as at 6 and 12 months.

following abdominal aortic surgery, post-operative outcomes are considered favorable with a rapid recovery of respiratory, renal functions and intestinal transit, with limited cardiac events. complications are still frequent after the classic open abdominal surgery. in abdominal aortic surgery, "mini" abdominal incision has been proposed as an alternative to the classic large surgical approach. two mini surgical approaches are possible: mini lumbotomy with retroperitoneal approach, and mini laparatomy with transperitoneal approach. previous studies have only compared classic versus mini surgical approaches and many are retrospectives studies. pain control through the mini-incision surgery allowed early mobilization of patients, improved lung function, reduced muscle loss, and favoured intestinal motility. so far, no study has compared the results of two mini invasive aortic approaches. the aim of this prospective randomized study is to compare two mini-invasive surgical approaches and to determine which of them allows the improvement of surgical outcomes with less morbi-mortality.

Eligibility criteria:
inclusion criteria: * elective abdominal aortic repair. * abdominal aneurysm or occlusive aortic disease requiring intervention. * written consent previously provided by the patient. * affiliation to social security. * preliminary medical examination. exclusion criteria: * hostile abdomen. * juxta renal abdominal aortic aneurysm. * aneurysmal extension to the iliac arteries. * concomitant visceral arteries lesions. * urgent surgery. * contraindication to surgery.

Keywords: mini-lumbotomy mini-laparotomy retroperitoneal approach transperitoneal approach abdominal aortic surgery
yoga@work for reducing musculoskeletal pain in neck and shoulder

Conditions: Neck Pain; Shoulder Pain; Musculoskeletal Pain

Summary: work-related musculoskeletal disorders (msds) are disorders of muscles, tendons, joints and nerves which can affect all body parts, although the neck, upper limb and back are the most common areas. the peer-reviewed literature about workplace prevention describes a variety of interventions that have been implemented and evaluated.but only few studies show sustainable positive effects on symptom outcomes. yoga@work program was developed to self manage pain around neck and shoulder areas among office workers.


Eligibility criteria:
inclusion criteria: * office workers * willing to participate and give consent * non specific neck and shoulder pain exclusion criteria: * neck injury * trauma * cancer related pain * psychiatric disorder/ medication * pregnancy
neozol_follow-up study

Conditions: Locally Advanced Breast Cancer

Summary: breast cancer is the most common cancer in women and is the leading cause of death from cancer in france. the main types of treatment used to treat breast cancer are surgery, chemotherapy, radiotherapy, hormone therapy and targeted therapies. in locally advanced breast cancer, a neo-adjuvant chemotherapy treatment is currently recommended as it may provide a sufficient tumour response to allow for conservative breast treatment. zoledronic acid (zol) is an n-biphosphonate used in the prevention of bone complications and in the treatment of hypercalcaemia in vitro and in vivo studies have shown an effect of zol on tumour and endothelial cells, supporting an anti-tumour activity of n-biphosphonates. between april 2010 and october 2013, 50 patients with locally advanced breast cancer were randomized in the neozol study to receive neoadjuvant chemotherapy with (n=26) or without (n=24) zoledronic acid (clinicaltrials.gov identifier: nct01367288). the primary objective of this study was to evaluate the effect of the addition of zometa® to neoadjuvant chemotherapy on the change in serum vegf concentration before and after neoadjuvant treatment (i.e. at the time of surgery). assessment of long-term survival was not planned in the neozol study protocol. the objective of neozol_fu study is to evaluate the survival of patients included in the neozol study, 7 years after inclusion of the last patient. this study will provide essential data on the long-term survival and risk of relapse of patients with locally advanced breast cancer who have received neo-adjuvant chemotherapy with or without zoledronic acid (zometa®).


Eligibility criteria:
inclusion criteria: * woman who signed a written consent, included and randomised in the main analysis of the neozol study exclusion criteria: * patient's opposition to the use of her data in this study

Keywords: breast cancer zometa® survival survey neoadjuvant chemotherapy
study with gw274150 in patients with mild asthma

Conditions: Asthma

Summary: this is a study investigating whether 14 days of dosing with gw274150 has a beneficial effect on a model of asthma type inflammation called the allergen-induced late asthmatic response. this will be compared with the response after treatment with a dummy (placebo) and a tablet treatment for asthma called singulair (montelukast). subjects in the study will receive all 3 treatments in a random order. the study is double-blind so subjects will not know which treatment they are taking at any given time.


Eligibility criteria:
inclusion criteria: * mild asthma: taking reliever medication (e.g. salbutamol) only. * screening involves measuring responses to the lung challenge agents: allergen, amp, and methacholine. only those with specific types of response to these will be eligible for the study. exclusion criteria: * recent steroid treatment. * significant illnesses or diseases other than asthma.

Keywords: asthma allergen challenge
effects of healing touch on patients undergoing hematopoietic stem cell transplant

Conditions: Anxiety Disorder; Fatigue; Hematopoietic/Lymphoid Cancer; Pain

Summary: this randomized pilot clinical trial studies healing touch or usual care in improving quality of life in patients undergoing stem cell transplant. healing touch may improve the quality of life of patients undergoing stem cell transplant.

primary objectives: i. to estimate the effects of healing touch (ht) vs usual care in the following clinical outcomes of stem cell transplant (sct) patients; length of hospital stay, days to engraftment, and number of hospital readmissions during 100 days post-transplant. ii. to estimate changes in quality of life (qol) which occur during hospitalization of sct patients who receive ht vs. usual care. iii. to examine differences in effects of ht vs. usual care (uc) in patients receiving related allogeneic (allo) transplant compared to those receiving autologous (auto) transplant. outline: patients are randomized to 1 of 2 arms. arm i: patients receive daily ht sessions comprising pain drain, chakra connection, magnetic clearing, and mind clearing over 30 minutes from day 1 until 2 days before discharge from the hospital. arm ii: patients receive routine nursing care from doctors and nurses from day 1 until 2 days before discharge from the hospital. after completion of study treatment, patients are followed up for 100 days.

Eligibility criteria:
inclusion criteria: * currently undergoing autologous (auto) or related allogeneic (related allo) stem cell transplantation * admitted to the university (u) adult blood and bone marrow transplant unit (uibmtu) of the university of iowa hospitals and clinic * ability to provide written informed consent obtained prior to participation in the study and able to complete questionnaires * pregnant woman who are eligible for stem cell transplant are included in this study exclusion criteria: * patients with any significant history of non-compliance to medical regimens, with inability to grant a reliable informed consent or unable to complete questionnaires * patients with evidence of a significant psychiatric disorder by history that would prevent completion of the study will not be allowed to participate, i.e., schizophrenia, anxiety disorder, major depressive disorder and bipolar disorder * diagnosis of dementia or other disease affecting cognitive function * nursing women are excluded
in-hospital healthcare professionals' attitudes and their experience in performing cardiopulmonary resuscitation.

Conditions: In-hospital Cardiac Arrest

Summary: attitudes among healthcare professionals can possibly affect the treatment given in cardiac arrest situations. the attitudes of healthcare professionals towards cardiopulmonary resuscitation (cpr) has been poorly studied. the few existing previous international results shows attitudes reported by nurses as hesitation, fear of defibrillation, anxiety and fear of harming the patient. the aim of this study was to describe the attitudes towards performing cardiopulmonary resuscitation among in-hospital healthcare professionals, furthermore to assess if experience in performing cpr has an effect on attitudes.

data will be collected using questionnaires containing attitude questions. the questionnaires contains questions regarding attitudes towards being required to perform cpr (6 questions), previous experience in performing cpr (time since last performance and number of performances) and attitudes during the latest cpr performance (8 questions). all attitude questions are constructed as multiple choice questions. results regarding attitudes towards being required to perform cpr and attitudes during the latest cpr performance will be presented descriptively. to analyse a possible effect of time since cpr performance and number of cpr performances on attitudes during the latest cpr performance logistic regression will be used. response variables will be "yes" or "no" on 8 specific attitude questions with predictors consisting of time since cpr performance (0-3 months ago, 4-23 months ago and \>24 months) and number of cpr performances (1-3 times, 4-10 times and \>10 times).

Eligibility criteria:
inclusion criteria: * in-hospital healthcare professionals. * patient contact exclusion criteria: * absent during the survey * parental leave * leave of absence * sick leave.

Keywords: in-hospital cardiac arrest attitudes cardiopulmonary resuscitation cpr
emergency ventilator splitting between two or more patients (covid-19)

Conditions: COVID-19

Summary: the purpose of this study is to develop a safe, easily scalable, and simple method to split a single ventilator for use amongst two or more patients, thus serving as a capacity bridge to save patient lives until manufacturers can produce enough ventilators.


Eligibility criteria:
inclusion criteria: * phase i * undergoing routine thoracic surgery which will include the use of a dual lumen endotracheal tube at stanford. * phase ii * able to give consent * on venovenous extracorporeal membrane oxygenation for reason other than covid-19 * phase iii * able to give consent * infected with covid-19 and will likely require mechanical ventilation. exclusion criteria: * phase i * significant cardiac comorbidities * liver disease * phase ii * significant cardiac comorbidities * pre or post-transplant patient * infection with covid-19 * phase iii * co-infection with disease aside from covid-19 * severely ill requiring high ventilator requirements and not stable for ventilator splitting
accuracy of the apple watch series 4 for detection of heart rhythm: a pilot study

Conditions: Heart Rate Fast; Heart Rate Low

Summary: the objective of this study is to assess the accuracy of the apple watch 4 series watch in generating an ecg that is suitable for determination of heart rhythm compared to rhythms monitored via telemetry. secondary objective is to assess the accuracy of the apple watch 4 series watch in identifying atrial fibrillation when it is present.

the study will assess the accuracy of the apple watch 4 series watch when worn by post-operative cardiac surgery patients after they have transferred from the icu to the cardiac telemetry unit. during testing each subject will wear: 1. an apple watch 4 series watch for no more than 5 minutes. 2. standard continuous telemetry monitor the location of the watch (left or right wrist) will be randomly assigned. heart rate and rhythm will be assessed by obtaining tracings from the apple watch 4 series watch while at the same point in time obtaining tracings from a standard telemetry monitor. ecgs from the apple watch 4 will be collected by asking the patient to place his/ her finger on the digital crown of the apple watch 4 for 30 seconds. the rhythm displayed by the apple watch 4 will be viewed on the apple health app (available on the iphone 8) and will be saved for subsequent viewing and analysis. each enrolled patient will have a minimum of three assessments of heart rhythm per day for at least two days, generating a minimum of six data points per patient. after conclusion of the study for each subject, the ecg's from the health app pertaining to that subject will be reviewed by a board certified cardiologist as will the telemetry tracings. in order to obtain tracings of new onset post-operative atrial fibrillation. 50% of the subjects enrolled will be in sinus rhythm and 50% will be in atrial fibrillation at the time of enrollment.

Eligibility criteria:
inclusion criteria: * age \> 18 years * post-operative cardiac surgery patients on the cardiac telemetry floors at the cleveland clinic main campus exclusion criteria: * presence of a cardiac pacemaker * use of a radial artery graft for coronary artery bypass grafting * tattoos located on the skin of the wrist or forearm where the apple watch 4 will be placed

Keywords: post-op atrial fibrillation heart rhythm accuracy apple watch
nox4 and related biomarkers in adpkd

Conditions: Autosomal Dominant Polycystic Kidney Disease

Summary: to determine the value of nox4, markers of mitochondria injury and function, and oxidative stress as real-time biomarkers to assess disease severity in patients with early autosomal dominant polycystic kidney disease (adpkd).

this will be a cross sectional study and will include male and female, young (15-40-years) well characterized patients with early (egfr\>70ml/min/1.73m2) adpkd. patients with different classes of disease severity will be selected using the adpkd imaging classification. the study will include 60 class-1 (a-e) patients (n=12 per each sub-class).

Eligibility criteria:
inclusion criteria: * adpkd (based on ravine et al. criteria) * class 1 a-e according to imaging classification * male and female subjects 15 - 40 years of age * estimated gfr\> 70 ml/min/1.73 m2 (ckd-epi) * ability to provide written, informed consent exclusion criteria: * class 2 according to imaging classification * concomitant systemic disease affecting the kidney * diabetes mellitus * predicted urine protein excretion in \>1 g/24 hrs * use of antioxidants i.e. vitamins, nrf2 activators * abnormal urinalysis

Keywords: oxidative stress mitochondria injury and function nadph oxidase 4