Kornimate/medical-research-clean huggingface dataset:
evaluation of attachment, self-compassion and coping strategies in chronic pain patients

Conditions: Chronic Pain

Summary: compare the self-compassionate score by type of attachment, "safe" or "insecure", in chronic pain patients.

attachment theory proposes a theoretical model that helps us explain how the process of developing interpersonal relationships can affect the search for care and the response of individuals to an illness. self-compassion is a concept developed by kristin neff. it refers to the disposition of each individual to contain their feelings of suffering by a feeling of warmth, connection and care. the coping corresponds to the answers, the reactions, that the individual will develop to control, reduce or simply tolerate the aversive situation. coping can take the form of cognitions, affects and behaviors that an individual will put in place to deal with a situation. the three concepts (attachment, self-compassion, coping) seem to be interrelated, and they contribute to the explanation and management of chronic pain, in the spectrum of the bio-psycho-social model of pain. yet no study has measured these three variables together in chronic pain patients chronic and newly assisted patients at cetd (neurosurgery department, pain assessment and treatment center) (ie any patient seen for the first time in pain center, and included in the research during one of the three medical consultations preliminary to overall care at the cetd).

Eligibility criteria:
inclusion criteria: * chronic pain exclusion criteria: * legal protection measure * patients followed for cancer * patients followed for multiple sclerosis * patients followed for parkinson's disease * patients already followed in another cetd * decompensated psychiatric pathology
microwave radiometry thermometry for the diagnosis of critical limb ischemia in diabetic patients

Conditions: Diabetic Foot; Peripheral Arterial Disease; Ischaemic Neuropathy

Summary: diagnosis of vascular involvement in diabetic foot disease remains challenging. differential diagnosis between pure neuropathic or neuro-ischemic diabetic foot requires a combination of clinical examination, medical history and ankle-brachial index (abi) measurement, which is considered the "gold standard" non-invasive modality for limb ischemia diagnosis. however, in diabetic patients with suspected arterial ischemia resulting in tissue loss (critical limb ischemia; cli), false negative abi results are frequent due to monckeberg medial sclerosis producing incompressible vessels, while clinical signs are subjective and not accurate in posing definite diagnosis of cli. the investigators conducted a proof of concept study of the feasibility of microwave radiometry thermometry for non-invasive diagnosis of cli in diabetic patients with tissue loss.

this is a prospective, multi-centre, trial designed to investigate the he feasibility and efficacy of microwave radiometry thermometry for non-invasive diagnosis of cli in diabetic patients with tissue loss. the study included 80 patients, equally divided in four groups. group n: normal subjects; group dn: diabetic patients with verified neuropathic ulcers without vascular involvement; group dc: diabetic patients with cli and group ndc: non-diabetic patients with cli. all patients underwent mwr with the rtm -01-res device (university of bolton, uk) to record the mean internal tissue temperature of the foot. mwr is based on the principle that the intensity of radiation is proportional to tissue temperature. the specific device is not commercially available and has been developed to detect temperatures from internal tissues at microwave frequencies. foot temperature measurements were performed as near as possible at the site of ulceration in patients of groups dn, dc and ndc and in various sites in subjects of control group n.

Eligibility criteria:
inclusion criteria: * patients suffering from both insulin and not insulin dependent diabetes mellitus. * critical limb ischemia verified by both clinical examination, haemodynamic tests and digital subtraction angiography. exclusion criteria: * uncertainty regarding the absence of peripheral arterial disease in groups n and dn. * uncertainty regarding the diagnosis of critical limb ischemia for patients in groups dc and ndc.
miniject global long-term follow-up study

Conditions: Open Angle Glaucoma; Ocular Hypertension

Summary: the study will assess the long-term (up to 5 years) safety and performance in patients with open-angle glaucoma uncontrolled by topical hypotensive medications who had previously been implanted with a miniject glaucoma implant.

the study aims to assess long-term safety and performance of miniject glaucoma implant up to 5 years post-implantation. patients who received implant and were followed for 2 years in a previous study, will be invited to continue long-term follow-up from 2 to 5 years post-implantation at annual intervals. standard ophthalmologic assessments including measurement of intraocular pressure, fundus examination, ocular imaging, assessment of any untoward ocular events etc. will be performed.

Eligibility criteria:
inclusion criteria: * patient who received a miniject glaucoma implant within a prior clinical study * patient continues to have miniject implanted at the point of enrolment * patient must provide written informed consent to participate exclusion criteria: * individuals under tutorship or trusteeship * patient who is unwilling to return to the study visits and undergo study assessments, as required by clinical study protocol

Keywords: open angle glaucoma intra ocular pressure (iop) reduction glaucoma drainage device minimally invasive glaucoma surgery (migs) supraciliary space ocular hypertension
patient satisfaction after ingrown toenail surgery

Conditions: Ingrowing Nail With Infection

Summary: in this study, demographic characteristics (age, gender, which toe is involved, family history) of the patients who were operated because of ingrown nails were examined, and the post-operative satisfaction score of the patients was noted, and the recurrence rate and complications were recorded.

the study was designed as single-center, single-surgeon observational study. approximately 4000 patients who were operated on by the same surgeon between 2015-2020 due to ingrown nails were reached by phone, and patients' satisfaction was assessed by using the surgical satisfaction questionnaire (ssq-8). outcomes such as retrospective treatment processes and complications were asked using a questionnaire, and patients' demographic characteristics were also recorded.

Eligibility criteria:
inclusion criteria: patients who underwent ingrown toenail surgery patients who could be reachable by phone over contact details on medical records exclusion criteria: patients who were not reachable patients who underwent another surgery on the targeted foot rather than ingrown toenail surgery patients who had fractures on the targeted foot clinical diagnosis of alzheimer disease or patients who have lost their cognitive functions.

Keywords: patient satisfaction operative treatment ingrown toenail onychocryptosis
examining the relationship between core muscles and bladder issues in children

Conditions: Lower Urinary Tract Symptoms; Skeletal Muscle

Summary: the goal of this observational study is to learn about functional bladder problems in children. the main questions it aims to answer are: * does bladder symptoms in children have an effect on core muscles? * how do core muscles change based on an increase or decrease in these symptoms?

the study will be a novel investigation that elucidates the current state by comparing core muscle function outcomes with the type and severity of symptoms in children with lower urinary tract symptoms. it will shed light on the necessity of evaluating not only electromyographic activity during urination but also the overall function of core muscles in children with lower urinary tract symptoms. additionally, identifying core muscle dysfunctions in children with lower urinary tract symptoms will provide a new perspective in treatment. consequently, the project will not only contribute to the literature but also serve as a pioneering study that draws attention to the necessity of physical therapy consultation and a multidisciplinary approach in clinical assessment and treatment processes for pediatric urologists. the comprehensive and objective project aims to conduct a reference study on the subject, and the project results will lay the foundation for the development of prevention and improvement strategies. data will be collected using non-invasive transabdominal ultrasound and surface electromyography to evaluate core muscle functions, and symptom questionnaires. the relationship between core muscle functions and lower urinary tract symptoms in children will be examined. research questions: does lower urinary tract symptoms have an impact on core muscle functions in children? how do core muscle functions change according to an increase or decrease in these symptoms? the study is a cross-sectional research.

Eligibility criteria:
inclusion criteria: * to have a diagnosis of lower urinary tract symptoms according to the international children's continence society (iccs) diagnostic criteria, * to have a normal neurological examination, * not to have received pelvic floor rehabilitation in the last 6 months, * to be between the ages of 6 and 18. exclusion criteria: * to have structural (anatomical) problems in the urinary system such as ectopic ureter, urethral valve issues, * to have congenital and/or spinal cord injury, acquired neurogenic problems such as spinal dysraphism, pelvic trauma, * to have active febrile illness or urinary tract infection, or any biomechanical problem such as congenital thoracic deformities that may hinder or affect the evaluation, * to have cognitive or mental impairment in the child and/or parent.

Keywords: lower urinary tract symptoms children physical therapy core muscles
a randomized phase 3 study to evaluate two formulations of romosozumab in postmenopausal women with osteoporosis

Conditions: Postmenopausal Osteoporosis

Summary: the purpose of this study is to compare 2 formulations of romosozumab (amg 785) on bone mineral density (bmd) in postmenopausal women with osteoporosis.

upon confirmation of eligibility, participants were randomized in a 22:5:22:5 ratio to the following treatment groups: * romosozumab 90 mg/ml * placebo 90 mg/ml * romosozumab 70 mg/ml * placebo 70 mg/ml after completing a 6-month treatment period, participants entered a 3-month follow-up period with an end of study (eos) at month 9. for the analysis of efficacy endpoints, the 2 placebo groups were combined into a single placebo group. for safety analyses, the data for placebo were presented separately for each group.

Eligibility criteria:
inclusion criteria: postmenopausal women with osteoporosis at high risk for fracture defined as * bmd t-score ≤ -2.50 at the lumbar spine, total hip, or femoral neck and * a history of fragility fracture or at least 2 other risk factors exclusion criteria: * bmd t score \< -3.50 at the total hip or femoral neck. * history of hip fracture. * history of metabolic or bone disease (except osteoporosis). * use of agents affecting bone metabolism. * vitamin d insufficiency. * history of solid organ or bone marrow transplants. * hyper- or hypocalcemia. * hyper- or hypothyroidism. * hyper- or hypoparathyroidism.

Keywords: postmenopausal osteoporosis
assessment of efficacy and safety of topical administration of 1% glycopyrronium bromide (gpb) in patients with primary axillary hyperhidrosis and the assessment of long-term efficacy and safety of topical administration of 1% gpb cream in patients with primary axillary hyperhidrosis.

Conditions: Primary Axillary Hyperhidrosis

Summary: the aim of this study is to investigate the efficacy and safety of 1% gpb cream after 4 weeks of treatment compared with placebo with a sufficient number of patients to obtain statistically significant results, and to assess the long-term safety of 1% gpb cream.


Eligibility criteria:
inclusion criteria: * diagnosis of severe primary axillary hyperhidrosis with a hdss score of 3 or 4 * at least 50 mg of sweat production in each axilla measured gravimetrically at room temperature and at a humidity consistent with the normal climate in that area over a period of 5 minutes (patients should have acclimatized to that room for at least 30 minutes) * men and women aged 18 to 65 years at the time of informed consent with a body mass index of 18-32 kg/m2 * able to comply with protocol requirements, including overnight stays, blood sample collections as defined in the protocol subjects * willing and able to provide written informed consent exclusion criteria: * known allergy to any of the components in the investigational product. * hypersensitivity against glycopyrrolate * secondary hyperhidrosis, for example, hyperhidrosis that is secondary to other underlying diseases including hyperthyroidism, lymphoma and malaria, climacteric hyperhidrosis. * previous surgical treatment of hyperhidrosis including sympathectomy, surgical debulking of the sweat glands, subcutaneous tissue curettage and ultrasonic surgery. * botulinum toxin treatment in the prior 4 months. * angle closure glaucoma or its precipitation (narrow angle). * mycotic, other skin infections and other dermal disorder including infection at anticipated application sites in either axilla. * any condition or situation that, in the investigator's or sub-investigator's opinion, may interfere with the patient's participation in the study;

Keywords: excessive sweating
cytoreduction with or without intraoperative intraperitoneal hyperthermic chemotherapy (hipec) in patients with peritoneal carcinomatosis from ovarian cancer, fallopian tube or primary peritoneal carcinoma

Conditions: Peritoneal Carcinomatosis From Ovarian Cancer; Fallopian Tube Carcinoma; Primary Peritoneal Carcinoma

Summary: the purpose of this clinical trial is to investigate whether the administration of hipec with cisplatin (75 milligrams per square meter of body surface) after surgical cytoreduction in women with ovarian, tubal or primary peritoneal carcinoma increased disease-free survival period compared with patients without hipec treatment.


Eligibility criteria:
inclusion criteria: * peritoneal carcinomatosis arising from ovarian epithelial carcinoma (stage iii or higher), carcinoma of the fallopian tube and primary peritoneal carcinoma. * residual tumor \< 2.5 mm after completion of cytoreductive surgery. * aged \< 75 years. * baseline ecog 0-1 (eastern cooperative oncologic group). * adequate bone marrow function with hemoglobin ? 8 g/dl (after correction for iron deficiency anemia), white blood cell count ? 3,000/mm3, platelets ? 100,000/mm3. * adequate renal function with creatinine ? 1.5 mg/ dl. * adequate liver function with bilirubin levels ? 1.5 mg / dl and ast and alt ? 80 iu / l. * optimal cardiopulmonary function. * in recurrences, disease-free interval \> 6 months. * voluntary and signed written informed consent. exclusion criteria: * extraperitoneal tumor disease. * suboptimal debulking (residual tumor \> 2.5 mm). * previous history of other malignancies (excluding skin) * intestinal obstruction at the time of evaluation. * renal failure. * heart failure. * uncontrolled infection. * pregnant or lactating patients. * in recurrences, disease-free interval \< 6 months.
a modified sinus floor elevation technique - a pilot study on 12 patients

Conditions: Maxillary Sinus; Atrophy

Summary: the aim of the present study is to establish a modified minimally invasive surgical technique for sinus floor augmentation with a residual bone height of 3-6mm. hypothesis: the investigators expect that the present surgical technique allows to achieve an adequate implant bed of at least 10mm height after a healing period of 3-5 months. further the modification of the technique enables a reduced patient stress level.


Eligibility criteria:
inclusion criteria: * residual bone height of 3-6mm * residual bone width of \>4mm exclusion criteria: * not treated periodontal disease * smoker (\>5cig/day) * acute or chronic sinusitis
effects of personalized training program on coronary flow reserve in healthy volunteers

Conditions: Coronary Artery Disease; Heart Infarction

Summary: this study investigates whether an individualized exercise program, including a personal trainer, can improve cardiovascular status quantified with ultrasound to assess coronary flow reserve and other non-invasive techniques. the subjects in the study will be divided into two groups; one group will have a personalized exercise- and nutrition program and the other group will have acess to a gym membership, but no personal trainer.

coronary heart disease is one of our most common diseases that causes significant morbidity and mortality. because the risk of serious cardiovascular events, such as myocardial infarction and death, is evident in this patient population, it is of utmost importance to develop diagnostic methods to identify patients at risk. the most appropriate diagnostic methods are those that are safe to implement for both patient and physician, but also accessible and cost-efficient. by using non-invasive techniques such as ultrasound, coronary artery function can be examined as coronary flow reserve (cfr). in the platform of non-invasive techniques used by the investigators for examinations of cardiovascular status, other methods are included, such as measurement of intima-media thickness in the carotid and radial arteries. the investigators goal is to compare the group with the personalized program with its placebo, and to compare the two study-groups with each other, to investigate whether the personalized program provides greater health benefits.

Eligibility criteria:
inclusion criteria: * non-smokers * no current medication, * no known diseases that require regular medication * no known risk factor for cardiovascular disease (hypertension, hyperlipidemia, diabetes, heredity, obesity, peripheral vascular disease) * no physically fit athletes. exclusion criteria: * ongoing treatment with medicine containing dipyridamole (asasantin, persantin) * known hypersensitivity to adenosine * chronic obstructive pulmonary disease * atrial fibrillation or other obvious arrythmias * av-block grade 2 or higher * other serious illness
the ability of perfusion index and positional perfusion index variation to predict spinal anesthesia-induced hypotension in elderly patients

Conditions: Spinal Anesthesia Induced Hypotension

Summary: in this study, we will test the ability of positional perfusion index variation to predict post-spinal anesthesia hypotension in elderly patients.


Eligibility criteria:
inclusion criteria: * 65 years of age or more. * asa score i \& ii. * patients scheduled for surgeries under spinal anesthesia. exclusion criteria: * negative consent. * pre-existing hypertension * diabetes mellitus or autonomic neuropathy. * emergency operations. * absolute contraindications or failure to perform spinal anesthesia.
comparison of rigid annuloplasty ring with a band in the correction of secondary tricuspid insufficiency

Conditions: Tricuspid Regurgitation

Summary: randomized study which include comparison rigid ring and band devices in treatment tricuspid regurgitation.

study include 308 patients. patient will be randomized and 154 patient will receive band for treatment tricuspid regurgitation, rest patient will receive rigid ring. follow up will be 1 year. primary outcome - freedom of moderate or severe regurgitation. secondary outcome - rv function, quality of life.

Eligibility criteria:
inclusion criteria: * moderate or severe tricuspid regurgitation exclusion criteria: * refusal to participate in the study

Keywords: tricuspid regurgitation insufficiency, tricuspid valve valvular annuloplasty cardiac valve annulus repair
the usefulness of self-expandable metal stents(sems) for malignant gastric outlet obstruction: a prospective study using new designed stents

Conditions: Malignant Gastric Outlet Obstruction

Summary: the purpose of this study is to evaluate usefulness of new designed winged stent(sems).


Eligibility criteria:
inclusion criteria: 1. gastric outlet obstruction symptom 2. diagnosis of gastric outlet obstruction by radiologist or endoscopist 3. gastric outlet obstruction by malignant disease 4. aged over 19 5. informed consent exclusion criteria: 1. gastric outlet obstruction by benign disease or infectious disease 2. could not endoscopic intervention by poor general condition 3. refusal of patient

Keywords: winged stents self-expandable metal stents(sems) partial covered uncovered endoscopic insertion
a prospective safety follow up study of subjects enrolled in study a4321001 and who have received drug product

Conditions: Siderosis

Summary: this protocol intends to detail investigations necessary to evaluate the ocular safety of subjects enrolled in study a4321001 and who have received formulated drug product (lot 8716-098).


Eligibility criteria:
inclusion criteria: * a subset of subjects enrolled in study a4321001 and who have received formulated drug product (lot 8716-098) will be included in the safety follow up study. exclusion criteria: none
an observational study of optive plus® for the treatment of dry eye disease

Conditions: Dry Eye Syndromes

Summary: this is an observational study of optive plus® in patients with dry eye disease in a routine clinical setting. treatment decisions are made by the physician and reflect the physician's current standard of care.


Eligibility criteria:
inclusion criteria: * diagnosis of dry eye * physician decision to treat with optive plus® in accordance with the physician's standard practice exclusion criteria: * none
uss training to improve social function in people with psychosis

Conditions: Psychosis

Summary: psychotic spectrum disorders (psd) are associated with poor social function. by doing this study, the investigators hope to learn which of two different types of 2-month long training courses is more effective in improving day-to-day interactions and quality of life.

participants will be randomly assigned to one of the two training courses. all participants will be asked to fill out questionnaires, engage in interviews, and complete paper and pencil tasks at the beginning of the study, at the halfway point of the training course (1 month), and end of the training course (2 months), and another 2 months later. one training focuses on how to make good judgments about what other people may be thinking or feeling in social situations, and why people might act in certain ways in different situations. the other training focuses on different strategies for handling everyday problems and stressors. both trainings are done in one-on-one sessions with a research staff member. there will be 16-20 training sessions, each about 45-60 minutes long. the investigators will ask participants to attend 2 training sessions per week, so the total training time should be about 2 months.

Eligibility criteria:
inclusion criteria: * veteran with diagnosis of psychotic disorder (e.g. schizophrenia, schizoaffective disorder, delusional disorder, psychosis nos, etc); * psychiatrically stable (30 or more days since last hospitalization/change in psychiatric medication) * fluent in english * able to provide legal written informed consent exclusion criteria: * current substance use disorder * developmental disability * severe, uncorrected auditory/visual impairment * diagnosis of medical or neurological illness known to impair brain function including dementia, presence of seizures, history of head trauma with loss of consciousness \> 1hr, or clear cognitive sequelae from other illness or injury * currently enrolled in another treatment study targeting, or expected to impact, functioning.

Keywords: psychosis social function social cognition