Kornimate/medical-research-clean huggingface dataset:
the effect of quran of post operative pain

Conditions: Postoperative Pain

Summary: postoperative pain management is crucial for surgical patients. management of postoperative pain entails reducing painful symptoms, improving the quality of recovery and resuming normal daily living activities. in addition to the benefits derived from relieving postoperative pain in women undergoing cesarean section, prolonged immobility as a result of pain during puerperium is associated with risk of thromboembolic disease. postoperative pain has negative physiological and psychological impact on patients' well-beings and delays the postoperative recovery. pain may also impair the mother's ability to provide an optimal care for her infant in the immediate postpartum period. besides that, it also reduces the maternal ability to breast-feed her infant effectively. effective pain relief should not interfere with the mother's ability to move around and care for her infant, and that it results in no adverse neonatal effects in breast-feeding women. non-pharmacological techniques for reduction of pain are growing rapidly. spiritual intervention with listening to quran recitations as an adjunctive therapy in the postoperative period is a non-pharmacological technique that is inexpensive, non-invasive and has no side-effects. spiritual and islamic implication could improve postoperative pain 6-8 hours and 24-30 hours in muslim patients undergoing abdominal surgery. however, there is limited number of published studies on the effect of spiritual and religious intervention on pain after cesarean section. listening to quran recitation elicits a relaxation response of calmness, mindfulness, and peacefulness in muslims. pray therapy results in optimal harmonization, which improves psychological, social, spiritual, and physical health status. the current study aims to investigate the effects of listening to quran recitation on pain intensity among patients after cesarean section according to the cultural, social and economic differences in egypt.


Eligibility criteria:
inclusion criteria: * pregnant muslim women * term (37-40 weeks) gestation * uncomplicated singleton pregnancy * scheduled for elective lower segment cesarean section under spinal anesthesia exclusion criteria: * any medical diseases * hearing impairment * any contraindication to spinal anesthesia
diagnosis of gastric intestinal metaplasia with high definition endoscopy and optic enhancement

Conditions: Gastric Intestinal Metaplasia

Summary: the purpose of this study is to assess whether high definition endoscopy with optic enhancement can reduce the biopsy number needed per patient for the detection of gastric intestinal metaplasia without the loss of corresponding diagnostic yield

gastric intestinal metaplasia is regarded as an important premalignant lesion for intestinal type gastric cancer. currently, the histological assessment of gastric intestinal metaplasia still relies on the biopsies took from five sites that the updated sydney system recommended. however, the updated sydney system biopsy protocol needs more biopsy number and procedure time, for it is unable to satisfy the diagnosis of gastric intestinal metaplasia. optic enhancement is a novel image-enhanced endoscopy system. targeted biopsy protocol based on high definition endoscopy with optic enhancement will be possible for the diagnosis of gastric intestinal metaplasia. this study aims to compare the diagnostic yield of gastric intestinal metaplasia from high definition endoscopy with optic enhancement targeted biopsies and a standard biopsy protocol and assess whether high definition endoscopy with optic enhancement can reduce the biopsy number needed per patient for the detection of gastric intestinal metaplasia without the loss of corresponding diagnostic yield.

Eligibility criteria:
inclusion criteria: * patients with dyspeptic symptoms and aged 40 years or older * or patients with helicobacter pylori infection, or histologically verified gastric intestinal metaplasia or atrophic gastritis * or patients with family history of gastric cancer exclusion criteria: * presence of gastrectomy, acute gastrointestinal bleeding, or known gastric neoplasia * presence of conditions unsuitable for endoscopy procedure including coagulopathy, impaired cardiopulmonary function , pregnancy or breastfeeding * inability to provide informed consent
treatment with radiofrequency in patients with chronic pelvic pain and history of endometriosis

Conditions: Endometriosis; Chronic Pain; Quality of Life

Summary: managing chronic pelvic pain in patients with a past history of endometriosis might be a challenge for the gynaecologist. the objective of this study is to evaluate pelvic pain after treatment with radiofrequency in patients with chronic pelvic pain and surgery for endometriosis.

patients with pelvic chronic pain and a past history of endometriosis without imaging evidence of endometriosis in the present will be enrolled in this study. the main objective of this study is to evaluate improvement of pelvic pain these patients. moreover, quality of life and sexual function will be also assessed. patients who are enrolled will come once a week per eight weeks to the hospital to have 30 minutes treatment with radiofrequency. they will be randomised in two groups, one receiving the radiofrequency and the other not (the device will be not give the energy). at the enrollement visit, the sf-36, vas score, anxiety and depression tests and sexual function tests will be answered the patients. at the end of the treatment, and one month after the end, they will answer the same questionnaires.

Eligibility criteria:
inclusion criteria: * chronic pelvic pain * past surgery for endometriosis exclusion criteria: * active endometriosis, diagnosed by imaging techniques * presence of other diseases that can cause chronic pelvic pain * contraindication for the radiofrequency use: pregnancy, metallic prothesis
efficacy and safety of oral salmon calcitonin in patients with knee osteoarthritis

Conditions: Osteoarthritis

Summary: the purpose of this phase iii study is to evaluate the efficacy and safety of oral salmon calcitonin in the treatment of patients with osteoarthritis of the knee.


Eligibility criteria:
inclusion criteria: * medical history and symptoms of knee osteoarthritis exclusion criteria: * any other disease or medication affecting the bone or cartilage. * any clinical signs or laboratory evidence diseases, which in the investigator's opinion would preclude the participant from adhering to the protocol or completing the trial. other protocol defined inclusion/exclusion criteria may apply

Keywords: osteoarthritis, oral salmon calcitonin, treatment, efficacy, tolerability
the effects of estradiol and progesterone on arginine vasopressin regulation and serum sodium concentration

Conditions: Exercise Induced Hyponatremia

Summary: women are at greater risk for exercise-induced hyponatremia (low blood sodium concentration) and this risk has been attributed to their lower body weight and size, excess water ingestion and longer racing times relative to men. while these factors contribute to the greater incidence of hyponatremia in women, it is likely that their greater levels of estradiol in plasma and/or tissue also play a role in increasing the risk of hyponatremia in women. more importantly, estradiol may also leave women more susceptible to the extreme consequences of hyponatremia (i.e. brain damage, death). hyponatremia is generally attributed to inappropriately elevated levels of the hormone arginine vasopressin (avp). avp is the most important hormone controlling water retention in the kidney. earlier studies in our laboratory have demonstrated that estradiol lowers the threshold for thirst sensation and avp release during exercise. the purpose of these studies is to test the hypotheses that in women with a history of hyponatremia, estradiol lowers the thresholds for thirst and avp release, leading to greater fluid retention, lower blood sodium concentration during endurance exercise in the heat. however, we further hypothesize that progesterone administration along with estradiol administration will attenuate the effect of estradiol on the regulation of thirst and avp, normalize fluid retention, and serum sodium concentration during endurance exercise in the heat. in women without a history of hyponatremia, we expect that estradiol administration will lower the thresholds for thirst and avp release, but will not increase fluid retention or reduce blood sodium concentration during endurance exercise in the heat. we hypothesize that progesterone administration along with estradiol administration will attenuate the effect of estradiol on thirst and avp, but have no effect on fluid retention or serum sodium concentration during endurance exercise in the heat. to test these hypotheses, women will perform endurance exercise in the heat under three hormonal conditions: 1) during gonadotropin-releasing hormone (gnrh) antagonist alone--which will suppress estradiol and progesterone; 2) during gnrh antagonist+estradiol; and 3) during gnrh antagonist+estradiol+ progesterone. during exercise, fluid will be replaced with either water or a carbohydrate-electrolyte beverage (random assignment).


Eligibility criteria:
inclusion criteria: * healthy volunteers (18-35 yrs) with and without previous exercise induced hyponatremia exclusion criteria: * conditions that would preclude safe exercise or safe use of hormones
polypharmacy outpatient clinic

Conditions: Polypharmacy

Summary: to investigate the effect of physician-initiated, medication reviews in geriatric patients on self-reported health-related quality of life, admissions, mortality and falls.

aim: to investigate the effect of physician-initiated, medication reviews in geriatric patients on self-reported health-related quality of life, admissions and mortality. trial design: randomized trial with polypharmacy intervention in addition to standard geriatric care. after referral to the geriatric outpatient clinic (but before the first visit), a medical secretary screens the patient's medication on the electronic medication list. if the patient is taking more than 8 different drugs, the patient is randomized to either standard geriatric care or standard geriatric care plus polypharmacy intervention. during the first visit, the patient is informed of the project and asked for written, informed consent. if given, we collect data regarding the patient's medication and any medication changes during the intervention, demographics, frailty (frail scale), charlson comorbidity index, self-reported history of falls, recent admissions, self-reported, health-related quality of life (eq-5d-5l) and death. data is collected at baseline, 4 months follow-up and 13 months follow-up. participants: all randomized, polymedicated (\>8 drugs) patients referred to the geriatric outpatient clinic. outcomes: the primary outcome is the between-group difference in the eq-5d-5l difference (self-reported, health-related quality of life) between baseline and 13 month follow-up. the secondary outcomes are number of medications, number of successful medication discontinuations, number of admissions and visits to the emergency department, self-reported low-energy falls, and death.

Eligibility criteria:
inclusion criteria: * new referral to the geriatric outpatient clinic * more than \> 8 different substances in drugs on the electronic medication list before the first visit. regular and prn drugs count. excluding topical treatment (eye drops, ear drops, creams etc) but including inhalation, excluding antibiotics with limited duration, excluding multivitamins, and excluding protein drinks. exclusion criteria: * inability (or refuses) to give informed consent (e.g. because of lack of interest, inability to understand the intervention or language barriers). * inability to understand the consent form and/or the intervention. * patients referred to the dementia diagnostics unit.

Keywords: polypharmacy medication review randomized deprescribing
impact of maternal covid-19 vaccines on breast milk

Conditions: COVID-19 Vaccines

Summary: prospective multicenter study the main aim is to study the impact of maternal covid-19 vaccination on breast milk immune, microbiological, and metabolic profile.


Eligibility criteria:
inclusion criteria: * priority groups for coronavirus (covid-19) vaccination (health and social care workers) following breastfeeding practices and receiving vaccines. exclusion criteria: * cessation of breastfeeding and vaccine side-effects requiring specific treatment and/or hospitalization.

Keywords: breast milk microbiota metabolites immune compounds growth and development
prescribing patterns of antihypertensive drugs in uncomplicated hypertension

Conditions: Hypertension,Essential; Cardiovascular Diseases

Summary: hypertension incurs substantial cardiovascular morbidity and mortality, particularly in primary prevention settings. general practitioners (gps) play a pivotal role in the management of hypertension in primary care, yet variations exist among gps. the determinants shaping gps' antihypertensive medication (ad) prescription patterns in the setting of hypertension remain ambiguous. this investigation sought to elucidate how gps' characteristics and professional activities influence ad prescriptions. a cross-sectional study utilizing a sample of 2,165 gps was conducted in normandy, france, in 2019. the ratio of ad prescriptions to overall prescription volume was computed for each practitioner. gps were classified as 'low' or 'high' ad prescribers based on the median of this ratio. the ratio was examined in relation to gps' demographic and professional variables such as age, gender, practice setting, years of experience, consultation frequency, the demographics and socioeconomic status of their patient panels, and prevalence of chronic conditions in patients. these associations were explored using both univariate and multivariate analyses.


Eligibility criteria:
inclusion criteria: * all patients who had at least one visit to their gp in 2019 were included, but minors were omitted. exclusion criteria: * minors

Keywords: hypertension prescriptions primary care
validation of new diagnostic indices to simplify hyponatremia therapy assessment in patients on thiazide diuretics

Conditions: Thiazide Associated Hyponatremia

Summary: this study is looking at two new parameters, asid and chu, to see if these can help physicians to distinguish between different causes of low sodium levels (hyponatremia) in patients taking a medicament against high blood pressure (thiazide). researchers also want to see if using these new parameters to decide on treatment works just as well, or better, than the current standard treatments.

thiazide or thiazide-like diuretics associated hyponatremia (thiazide associated hyponatremia, tah) has a high prevalence in hospitalized patients. patients might present either with a hypovolemic hyponatremia due to volume loss as a diuretic effect of thiazide, or with a syndrome of inadequate antidiuresis (siad) like hyponatremia in need of fluid restriction. canonical urine indices are not useful in differential diagnosis, being directly influenced by thiazide itself. current guidelines suggest the use of a clinical volume status assessment, but this approach has a poor diagnostic performance, with less than 50% of patients being rightly diagnosed thru that. the investigators showed in a retrospective analysis the possible role of strong apparent ion difference (asid) and of chloride and potassium levels in urine (chu) in differential diagnosis of tah. the goal of this study is to investigate prospectively whether implementation of asid and, in case of inconclusive asid, chu, allows a correct differential diagnosis and treatment of tah.

Eligibility criteria:
inclusion criteria: * hospitalized patients presenting at university hospital basel * aged 18 years or older * able to give informed consent as documented by signature * with serum sodium level \< 130 mmol/l and serum osmolality \< 300 mosm/kg * with treatment with thiazide or thiazide-like diuretic exclusion criteria: * symptomatic hyponatremia in need of 3% hypertonic solution or intensive care treatment * inability or contraindications to undergo the trial (i.e., any acute severe cardiovascular event requiring an immediate intervention) * decompensated liver cirrhosis child c * decompensated heart failure nyha iii or higher * severe valve impairment * untreated adrenal insufficiency * severe kidney disease in need of dialysis * pregnancy or breastfeeding * end of life care * inability to follow the study procedures (i.e., language problem, dementia or critical illness).

Keywords: hyponatremia strong apparent ion difference potassium levels in urine
the role of antibiotic prophylaxis in cleft palate and velopharyngeal insufficiency repair

Conditions: Cleft Palate

Summary: cleft lip and palate surgical repair is one of the most common procedures performed by plastic and reconstructive surgeons in the world. with this in mind, it is curious that no consensus exists regarding the usage of postoperative antibiotics or the effects this might have on wound complications such as cellulitis, dehiscence, or fistula formation. the surgical bed in cleft lip/palate repair is known to harbor a myriad of pathological organisms, indeed the human bite is one of the more clinically and microbiologically significant injuries to treat. this research study is to elucidate the role, if any, that prophylactic antibiotics have in the prevention of complications post cleft palate (cp) and vpi repair and potentially establish a new paradigm of care.

this will be a randomized prospective research study. participants who will undergo an elective cp or vpi surgery will be randomized to receive either 1) antibiotics or 2) nothing postoperatively. all participants will be evaluated for infection, fistula formation, and dehiscence upon discharge and at 30-day follow-up based on standards of care.

Eligibility criteria:
inclusion criteria: 1. ages 1 month to 60 years 2. subjects undergoing independently scheduled elective cleft palate of vpi repair 3. do not meet any exclusion criteria exclusion criteria: 1. any repeat repair 2. symptoms of upper respiratory infection 3. immunosuppressed 4. allergy to amoxicillin or any other penicillins 5. antibiotic usage \<2weeks prior to scheduled surgery other than immediate pre-operative antibiotics 6. inability to follow up

Keywords: cleft palate surgery antibiotic treatment
exploring participant preference for screening methods and experience into colorectal cancer screening programme

Conditions: Screening for Colon Cancer; Survey and Questionnaire

Summary: the goal of this low-risk interventional study is to analyze participants' assessment of colorectal cancer screening program through screening method preference and experience after fobt analysis in screaned participant population for colorectal cancer; could include any of the following: both sexes, age 50-69 years, asympthomatic volunteers. the main aims to answer are: * values of experience of participants into screening programme. * values of preferences of participants for screening methods. participants will answer two questionnaires and they'll be given their information and clinical data to investigator or health personnel.


Eligibility criteria:
inclusion criteria: * participants ages from 50 to 69 years (both included) at the time of informed consent signed. * participants invited to participate in population-based screening programme who are eligible to undertake fobt at the primary health care center. * participants should sign an informed consent. they must understand the nature, significance, implications, and risks of the clinical study before signing the informed consent form. exclusion criteria: * participants who have not delivery a stool sample in the primary health care center before signing the informed consent form. * participants with a previous colonoscopy in consequence of a fobt positive result. * participants who are in a dependent personal or non-medical relationship with the sponsor or the investigators.

Keywords: colorectal cancer screening programme experience preference questionnaire
safety and tolerability of lithium in spinocerebellar ataxia 2 (sca2)

Conditions: SPINOCEREBELLAR ATAXIA 2

Summary: the purpose of this study is to determine safety and tolerability of the treatment with lithium in spinocerebellar ataxia 2. moreover, clinical symptoms, neuronal loss, quality of life and depressive symptoms, will be considered to further investigate the effect of lithium therapy.

patients will be progressively enrolled in the study and undergo a screening visit to test for inclusion/exclusion criteria. patients will then be randomized to receive either lithium carbonate or placebo. patients will visit study center at 2, 4, 8, 12, 24, 36 and 48 weeks, for endpoint and laboratory assessments.

Eligibility criteria:
inclusion criteria: * molecular diagnosis of sca2 (≥34 cag in the ataxin-2 gene) * age ≥18, \<80 * sara score ≥8 exclusion criteria: * sara score \>32 * heart failure * liver disease * kidney failure * thyroid disease * sick sinus syndrome and/or significant ecg alterations * hyposodemia * treatment with diuretics * treatment with haloperidol and/or other antipsychotics * treatment with nsaids or corticosteroids * treatment with ace inhibitors * treatment with aminophyllines * treatment with mannitol * pregnancy and/or breastfeeding * acute diseases that might interfere with the trial

Keywords: sca2 lithium
risk of mental health conditions in children and young adults with inflammatory bowel disease and influence on health

Conditions: Inflammatory Bowel Diseases; Depressive Episode; Recurrent Depressive Disorder; Anxiety Disorder; Psychological Disorder; Self Harm; Suicide, Attempted; Parasuicide; Eating Disorders; Body Image Disorder; Attention Deficit Hyperactivity Disorder; Behavioral Disorder; Adjustment Disorders; Acute Stress Disorder; Schizophrenia; Bipolar Disorder; Post-traumatic Stress Disorder; Sleep Disturbance

Summary: this study is a large population-based analysis in the united kingdom (uk) using routine primary care data to investigate the impacts on quality-of-life outcomes and use of healthcare services in people aged 5 - 25 years diagnosed with inflammatory bowel disease (ibd) and the impacts of mental health conditions in those diagnosed with ibd.

this study will use routinely electronic medical record (emr) data from primary care practices within the optimum patient care research database (opcrd). stream 1 primary objective is to compare the prevalence and cumulative incidence of mental health conditions in children, adolescents and young adults (aged 5-25 years) with a diagnosis of inflammatory bowel disease (ibd), compared to matched population controls without a diagnosis of ibd. the secondary objective is to determine the severity of mental health outcomes in those with and without a diagnosis of ibd. stream 2 primary objective is to determine the impact of mental health conditions in children, adolescents and young adults (aged 5-25 years) diagnosed with ibd on quality-of-life indicators, such as records for absence from work or school, unemployment, sleep disturbance and substance abuse. the secondary objectives are to compare indicators of ibd severity, such as medication use, surgical intervention, nutritional supplement prescriptions and markers of nutritional status including underweight or growth retardation,and healthcare resource utilisation.these impacts and indicators will be assessed using participants that have been diagnosed with ibd, comparing those with the presence of a mental health condition to those without a mental health condition.

Eligibility criteria:
inclusion criteria: * aged between 5 years and 25 years * registration with a general practices (gp) contributing routinely collected electronic healthcare data to the optimum patient care research database (opcrd) for more than 6 months during the follow up period * a recorded diagnosis of ibd in the clinical record (cases) exclusion criteria: • none