Kornimate/medical-research-clean huggingface dataset:
a study investigating oral ozanimod (rpc1063) in pediatric participants with moderate to severe active ulcerative colitis

Conditions: Colitis, Ulcerative

Summary: the purpose of this study is to evaluate the effectiveness and safety of ozanimod (rpc1063) in achieving and maintaining clinical remission. ozanimod will be administered orally to pediatric participants with moderate to severe active ulcerative colitis (uc) who have had an inadequate response to conventional therapy.


Eligibility criteria:
inclusion criteria: * moderately to severely active ulcerative colitis (uc) diagnosed prior to the screening visit * evidence of uc extending beyond the rectum, as determined by baseline endoscopy * has had an inadequate response, loss of response to, or is intolerant to at least 1 of the following treatments for uc: oral aminosalicylates, systemic corticosteroids, immunomodulators, biologic therapy exclusion criteria: * diagnosis of crohn's disease or indeterminate colitis * has documentation of positive test for toxin producing clostridium difficile, or polymerase chain reaction examination of the stool * apheresis within 2 weeks of randomization * history of or currently active primary or secondary immunodeficiency, or participants with known genetic disorders as a cause for colitis other protocol-defined inclusion/exclusion criteria apply

Keywords: ulcerative colitis ozanimod pediatric
effect of self-directed and supervised pulmonary rehabilitation approach on cough and sputum.

Conditions: COPD; Pulmonary Disease

Summary: chronic obstructive pulmonary disease (copd)is a multifactorial, progressive chronic lung disease that causes airflow restriction. study was conducted to compare the effects of supervised and self-directed pulmonary rehabilitation on cough and sputum expectoration in patients of chronic obstructive pulmonary disease.

to compare the effects of supervised and self-directed pulmonary rehabilitation on cough and sputum expectoration in patients of chronic obstructive pulmonary disease. it was a randomised control trial and participants were copd patients.

Eligibility criteria:
inclusion criteria: * age: 40 to 60 * gender: both males \& females. * diagnoses with an exacerbation of copd. * informed consent obtained. exclusion criteria: * inability to provide informed consent or complete a self-administered questionnaire. * patients with trauma. * females who were pregnant and breastfeeding.
effects and safety of caspofungin and corticosteroids in pneumocystis pneumonia in non-hiv patients

Conditions: Pneumocystis Pneumonia

Summary: pneumocystis pneumonia is increasing in immunocompromised non-hiv infected patients. the effects and safety of caspofungin and corticosteroids is not certain in this population. all immunocompromised non-hiv patients with respiratory failure were randomized into caspofungin and non-caspofungin group and corticosteroids and non-steroids group. the major outcome is 28 day mortality, the second outcome are time of respiratory rate decreases to less than 25 breath per minute, body temperature lower than 37.3℃.


Eligibility criteria:
inclusion criteria: * immunocompromised non-hiv infected patients * partial arterial o2 pressure(pao2)/fio2≤300mmhg * diagnosed as pneumocystis pneumonia exclusion criteria: * younger than 16 years old * severe organ failure * allergic to sulfanilamide, caspofungin or corticosteroid

Keywords: caspofungin corticosteroids pneumocystis pneumonia immunocompromised non-hiv respiratory failure
physical cam therapies for chronic low back pain

Conditions: Chronic Low Back Pain

Summary: this is a pilot randomized trial intended to evaluate the effectiveness of acupuncture, chiropractic and massage for chronic back pain in older and younger adults.


Eligibility criteria:
* low back pain duration of at least 3 months; * low back pain occurring in the past week; * no numbness or tingling in the lower extremities; * no pain that radiates to below the knee; * no use of massage, chiropractic or acupuncture for any reason in the past year; * able to attend scheduled appointments; * able to hear, read, and understand english; * no low back pain surgery in the past 3 years; * no unexplained weight loss; * no previous vertebral or spinal fractures; * no previous non-traumatic bone fractures; * no other spinal pathology, including scoliosis, spinal stenosis, osteoporosis, or ankylosing spondylitis; * no cancer (except simple skin cancers) in the past 5 years; * no pacemakers; * no bleeding problems or anticoagulant use; * no major organ transplants; * no oral corticosteroid use for more than 4 consecutive weeks during the past year; * cannot be pregnant; * must be able to get down to and up from the floor by yourself; * able to walk 2 flat city blocks unassisted; * willing to participate in periodic telephone interviews.

Keywords: chronic low back pain acupuncture chiropractic massage therapy cam therapies
a study to assess the safety and effects of intravenous (iv) conivaptan on the hepatic hemodynamic response in cirrhotic patients

Conditions: Liver Cirrhosis

Summary: to evaluate the safety of iv conivaptan in stable euvolemic or hypervolemic cirrhotic patients, and to characterize the effects of iv conivaptan on the hepatic hemodynamic response in patients with cirrhosis.


Eligibility criteria:
inclusion criteria: * institutional review board (irb)/independent ethics committee (iec)-approved written informed consent and appropriate privacy language as per national regulations must be obtained from the subject or legally authorized representative prior to any study-related procedures (including withdrawal of prohibited medication, if applicable) * subject is euvolemic or hypervolemic (edematous) secondary to cirrhosis * subject has clinical evidence of portal hypertension by the presence of esophageal varices, ascites or both exclusion criteria: * clinical evidence of volume depletion or dehydration * subject has a history of bleeding from esophageal varices within three months before the start of the study

Keywords: conivaptan liver cirrhosis hypertension, portal
does visceral manipulation works in treating functional dyspepsia?

Conditions: Functional Dyspepsia

Summary: the goal of this study is to determine if visceral manipulation (vm) is effective in treating functional dyspepsia in addition to drug therapy. null hypothesis is that vm does not influence fd symptoms.

50 patients with functional dyspepsia (fd) diagnosed by general practitioners are randomized in two therapy group: 1) drug only group and 2) drug + visceral manipulation group. group 1 receive drug therapy for 4 weeks, group 2 receive drug therapy for 4 weeks and 4 visceral manipulation visits with weekly frequency (visit 1 at day 1 of drug therapy). fd symptoms are recorded with vas at baseline and after 1 and 4 weeks of therapy, and after 8 weeks (4 weeks after the finish of all therapies).

Eligibility criteria:
inclusion criteria: * clinical diagnosis of functional dyspepsia exclusion criteria: * diabetes mellitus * mental disturbance * thyroid gland dysfunction * intestinal, liver and biliary tract disease * concurrent medications that could interact with gi function * positive helicobacter pylori status

Keywords: functional dyspepsia, visceral manipulation
study to assess speed of onset and durability of effectiveness of upadacitinib in adult participants with moderate to severe crohn's disease (cd) in real world clinical practice.

Conditions: Crohn's Disease

Summary: crohn's disease (cd) is an incurable chronic inflammatory disorder of the gastrointestinal tract. this study will assess how safe and effective upadacitinib is in treating moderately to severely active cd in real world. speed of onset and durability of effectiveness will be assessed. upadacitinib is a drug approved for the treatment of cd. all study participants will receive upadacitinib as prescribed by their study doctor in accordance with approved local label. approximately 1200 participants will be enrolled in approximately 230 sites across the world. participants will receive upadacitinib as prescribed by their physician according to their routine clinical practice and local label. participants will be followed for up to 3 years. there is expected to be no additional burden for participants in this trial. study visits may be conducted on-site or virtually as per standard of care.


Eligibility criteria:
inclusion criteria: * a diagnosis of moderate-to-severe crohn's disease (cd). * participants initiating upadacitinib at the clinician's discretion as part of their routine clinical care; the decision to administer upadacitinib must be made prior to and independent of recruitment into the study. * participants prescribed upadacitinib in accordance with the approved local label. * able to understand and communicate with the investigator and comply with the requirements of the study. * willing to continue with study documentation after cessation of upadacitinib. * willing and able to participate in the collection of pro data via a cloud-based application on their personal or provided mobile phone or website app. exclusion criteria: * any contraindication to upadacitinib. * previously exposure to upadacitinib in a clinical trial. * currently participating in interventional research (not including non-interventional study, post-marketing observational study (pmos) , or registry participation). * initiation of upadacitinib prior to enrollment.

Keywords: crohn's disease cd upadacitinib
global investigation of therapeutic decisions in hepatocellular carcinoma and of its treatment with sorafenib

Conditions: Carcinoma, Hepatocellular

Summary: in this international non-interventional study safety and clinical data concerning the treatment of patients suffering from hepatocellular carcinoma (hcc) will be collected.


Eligibility criteria:
inclusion criteria: * outpatients with histologically/cytologically documented or radiographically diagnosed unresectable hcc who are candidates for systemic therapy and for whom a decision to treat with nexavar has been made. radiographic diagnosis hcc nis, needs typical findings of hcc by radiographic method i.e. on multi-dimensional, dynamic ct, ct hepatic arteriography (ctha)/ct arterial portography (ctap), or mri. * patients must have signed an informed consent form * patients must have a life expectancy of at least 8 weeks exclusion criteria: * exclusion criteria must follow the approved local product information

Keywords: hepatocellular carcinoma hcc sorafenib
full-leg vs below-knee elastic stockings for prevention of the post-thrombotic syndrome

Conditions: Deep Vein Thrombosis

Summary: prospective controlled randomized clinical trial. consecutive patients with acute proximal deep vein thrombosis of the lower extremities, with or without contemporary manifestations of pulmonary embolism, are randomized to receive either a below-knee or a full-leg graduated compression (30-40 mm hg at the ankle) elastic stocking for prevention of the post-thrombotic syndrome (pts). all patients are followed up to three years to assess the development of the pts, defined according to a validated clinical score (the villalta scale). the rate of pts is compared between the two study groups. in addition, there is an assessment of patients' compliance and tolerability of the two different devices.


Eligibility criteria:
inclusion criteria: * first episode of proximal deep vein thrombosis, as shown by compression ultrasound exclusion criteria: * previous ipsilateral deep vein thrombosis * preexisting chronic venous insufficiency * bilateral deep vein thrombosis * life expectancy lower than 1 year * severe arteriopathy of the lower limbs * known allergy to elastic stockings * lack of written informed consensus

Keywords: deep vein thrombosis of the lower extremities
research on suicidal ideation of university students in harbin city and cognitive behavior therapy

Conditions: Suicide

Summary: the purposes of this research are: * to understand the status of suicidal ideation, suicidal behavior, and depression in harbin university students; and * to analyse the infect factors of suicidal ideation and suicidal behavior. with cognitive behavior interventions on students with suicidal ideation, suicidal behavior, and middle or high degree of depression, the researchers can provide a scientific and effective intervention to the students. cognitive therapy for the prevention of suicide attempts: a randomized controlled trial. brown gk, ten have t, henriques gr, xie sx, hollander je, beck at. department of psychiatry, university of pennsylvania, philadelphia 19104, usa. gregbrow@mail.med.upenn.edu jama. 2005 aug 3;294(5):563-70.

by using suicidal ideation scale, to assess the status of suicidal ideation and suicidal attempt in 6000 university students in harbin city. about 300 students with suicidal ideation and depression disorder randomized into two groups (control and intervention groups) accept the cognitive behavior intervention. we will assess the depression after intervention.

Eligibility criteria:
inclusion criteria: * suicidal ideation or the scores of beck depression inventory ≧14 exclusion criteria: * have no suicidal ideation and the scores of beck depression inventory \<14

Keywords: suicidal ideation cognitive behavior therapy
fluorescence identification of melanoma by a multicenter based algorithm (flimma)

Conditions: Melanoma; Moles

Summary: all patients will undergo dermoscopic diagnosis and be documented with a video image storing. the diagnosis based on dermoscopy will be immediately documented. then, as a second diagnostic procedure, fluorescence diagnostics based on the two photon excitation from a dye-laser will be performed. the classification as non-melanoma or malignant melanoma by the medical device limes will also be documented immediately. afterwards, the lesion will be excised and undergo histopathologic examination by the respective histopathologist of the participating centers. the histopathologic diagnosis will serve as gold standard for subsequent evaluations of the diagnostic accuracy.


Eligibility criteria:
inclusion criteria: * patients ≥ 18 years of age * male or female * patients having pigmented lesions with suspicion of dysplastic nevus or melanoma, in whom an excision is performed in order to exclude or diagnose malignant melanoma * patients who gave their written informed consent. exclusion criteria: * patients with skin type v and vi according to fitzpatrick's scale; * where there is a risk that the scanning head is torn off be-cause the patient cannot be placed at rest (e.g. due to motoric disorders like tremor, convulsions, tics, compulsive acts * patients who cannot understand the patient information and provide informed consent * deep dermal lesions ≥ 5 mm beneath the stratum corneum * clinically or reflected-light microscopically obviously non-melanocytic lesions * peri- and subungual lesions * mucosal lesions * lesions with trauma, erosion (superficial defect), excoriation (defect down to the basement membrane) or ulceration (deep substantial defect) on more than 50 % of the lesion area (measurements must in any case not be carried out directly on the trauma, erosion, excoriation or ulceration) * tattooed lesions * pregnant or breast feeding women * patients suffering from albinism * lesions with dominant (\>50%) regression * lesions which are not suitable to fix the scanning cap

Keywords: dermoscopy
"is instrumentation necessary for "static" degenerative spondylolisthesis"

Conditions: Degenerative Spondylolisthesis; Spinal Stenosis

Summary: the purpose of this study is to determine whether instrumented lumbar fusion provides superior clinical outcomes in comparison to non-instrumented fusion in patients with "static" degenerative spondylolisthesis.

this study will determine whether instrumented lumbar fusion will provide superior clinical outcomes in comparison to non-instrumented fusion in patients with "static" degenerative spondylolisthesis. at the time of scheduling surgery, patients who meet the inclusion/exclusion criteria will be asked to participate. patients who agree, will be randomized to either non-instrumented or instrumented arthrodesis group. intra-operative, peri-operative, and post-operative data will be collected and compared. the investigators predict to get very similar clinical outcomes between the two groups, with possibly less complications from the non-instrumented group and definitely a reduction in cost compared to the instrumented group.

Eligibility criteria:
inclusion criteria: 1. patients with stable l4-5 spondylolisthesis on lumbar flexion and extension radiographs. stability will be determined by the treating physician. 2. patients with concomitant spinal stenosis. 3. laminectomy at any lumbar levels of stenosis. 4. fusion only at l4-5 level. exclusion criteria: 1. prior lumbar spine surgery 2. multi-level spondylolisthesis 3. anterior interbody work/fusion 4. tumor 5. infection 6. trauma
customized self-controlled power-driven or mechanical orthoses for the upper limb - a pilot study

Conditions: Upper Limb Deformities, Congenital

Summary: patients with congenital or acquired upper limb structural abnormalities and peripheral nerve or brachial plexus palsies have significant loss of function. the use of orthoses may improve function particularly in performing specific tasks for which the orthoses are designed, depending on the patients' deficiencies and needs. the performance of orthoses may be enhanced by being light-weight, motor-driven, and ergonomic. this pilot, prospective study is designed to test the feasibility and effectiveness of the specially designed orthoses.


Eligibility criteria:
inclusion criteria: * patients with any congenital or acquired upper limb structural abnormalities * patients' condition is not suitable for surgical intervention or patients are not keen for surgical treatment exclusion criteria: * patients have no available muscle signal input * patients fitted with a pacemaker or an implantable cardioverter defibrillator (icd) or other implantable electrical devices * patients with contact dermatitis
project neuroartemis

Conditions: Stimulant Use; Human Immunodeficiency Virus (HIV); Depression

Summary: the purpose of this research is to understand how chronic stress affects the way our brain and immune systems function, and in turn how this affects the way people feel, think, and behave. by learning more about how these processes work, the hope is to be able to develop better treatments to help with problems like depression and substance use. this study is intended for individuals that are hiv positive, currently taking prescription antiretroviral medications, and use stimulants. through this intervention, the aim is to determine if this positive affect intervention can lead to reductions in stimulant use and depressed mood.

participants who meet initial eligibility criteria will complete a baseline assessment that includes psychosocial and behavioral measures, biospecimen collection, and an mri brain scan. participants will then be randomized to either: 1) artemis; or 2) a waitlist control (wlc) condition. artemis participants will receive 5 sessions delivered individually over zoom across 3 months. all participants (including wlc) will receive contingency management (cm) for antiretroviral therapy (art) adherence to support sustained viral suppression over the active phase of the trial. during the intent-to-treat period, assessments at 3- and 6-month follow-ups will characterize changes in neural activity (assessed via fmri) and conserved transcriptional response to adversity (ctra) leukocyte signaling (assessed via rna sequencing) as plausible mediators of behavioral outcomes following artemis. wlc participants will be offered the artemis intervention after a 6-month delay.

Eligibility criteria:
inclusion criteria: * 18-59 years old * weekly use of stimulants reported in the past month or a score of 4 or more on the alcohol, smoking and substance involvement screening test (assist) * confirmed hiv diagnosis * current receipt of daily oral antiretroviral therapy (art) medication * english fluency/literacy exclusion criteria: * acute brain infection (e.g., neurosyphilis, toxoplasmosis) * acutely symptomatic bipolar i or psychotic disorder * prescription for immunomodulatory medications or other immunotherapy * any mri contraindications * if applicable, on antidepressant medication regimen for at least 2 months

Keywords: hiv stimulant use substance abuse chronic stress
genetics of cardiovascular reactivity in black youth

Conditions: Cardiovascular Diseases; Heart Diseases; Hypertension

Summary: to evaluate individual differences in cardiovascular responses to acute stress in black adolescents.

background: the prevalence and severity of essential hypertension (eh) are greater among black americans than other ethnic groups in the u.s. blacks are at increased risk for target organ damage from elevated blood pressure, including heart disease, stroke, and endstage renal failure. there are significant ethnic differences in cardiovascular reactivity (cvr) to stress, which is a risk factor for elevated blood pressure. studies have shown that cvr to stress is stable over time, heritable, and predictive of future elevations in blood pressure and the development of essential hypertension. these properties make measures of cvr a valuable intermediate for genetic studies of hypertensive risk. design narrative: the genetic epidemiology study will test the hypothesis that individual differences in cvr to acute stress in black youth are associated with well defined polymorphisms in candidate genes related to blood pressure including: 1) alpha- and beta-adrenergic receptor genes; 2) genes involved in catecholamine metabolism; 3) genes involved in endocrine function; 4) genes involved in the renin angiotensin system. by focusing on normotensive youth at risk for developing essential hypertension, the investigators hope to identify genes associated with the onset, rather than the sequelae, of hypertension. moreover, given that cvr to acute stress is defined as a change in cardiovascular function evoked by an environmental manipulation of stress, the research is inherently a study of gene-environment interactions. a total of 500 unrelated black adolescents and young adults (equal numbers of males and females), 15-21 years of age will be studied. buccal cell samples will be collected for dna extraction from all subjects for genetic association analyses. impedance cardiography and blood pressure monitoring will be used to assess components of cvr to stress during video game, mental arithmetic, cold pressor, and whole body cold exposure tasks, all of which have been utilized or developed in the laboratory. various methods will be used to evaluate genetic associations with cvr to acute stress, including analyses of single nucleotide polymorphisms and haplotypes. supplementary analyses will evaluate potential gene-gene interactions and additional gene-environment interactions involving chronic environmental stress.

Eligibility criteria:
african american non-hypertensive, no chronic disease which would affect blood pressure