Kornimate/medical-research-clean huggingface dataset:
acupuncture for sleep disruption in cancer survivors

Conditions: Sleep Initiation and Maintenance Disorders; Breast Cancer

Summary: the proposed study will recruit 60 women with breast cancer who finished undergoing treatment who complain of persistent insomnia problems that began with onset of their cancer diagnosis. the eligible women would be randomized and stratified by sleep problems to two arms: (acupuncture arm vs. sham acupuncture) with a goal of having 48 patients complete the study (we anticipate about 20% attrition rate). the study interventions will begin after patients completed their treatment. the placebo control for acupuncture will be a validated sham acupuncture control assessments will be made with daily diaries and with weekly questionnaires. psg data will be collected on the subsample of the population. data will be gathered via pencil-and-paper measures before, during, immediately following, one month following the completion of treatment and six months after the conclusion of treatment. in addition, actigraphy data (objective sleep continuity data) will be acquired prior to and following treatment


Eligibility criteria:
inclusion criteria: * females diagnosed with breast cancer who are not currently undergoing cancer treatment (hormonal treatment is permitted). * the last cancer treatment ≥ 2 weeks prior to screening. * ≥ 21 years of age. * able to understand written and spoken english. * have a habitual bedtime between 9:00 pm and 3:00 am and a habitual rise time between 4:00 am and 11 am. * meet dsm-iv criteria for insomnia (determined by the of the duke structured interview of sleep disorders) with duration ≥ 1 month by screening. * willingness to discontinue the use of any current sleep aides (prescription, otc, or naturopathic agents). * properly executed informed consent. * karnofsky performance scale index score ≥ to 70, (patients who score between 61-69 might be included per pi's evaluation). * insomnia severity index (isi) \> 8 at screening. * able to travel to stanford university and vicinity for assessments and acupuncture treatments. exclusion criteria: * unstable medical or psychiatric illness (emini, current or within the last 5 years). * exposure to acupuncture within 6 months prior to screening. * currently pregnant or nursing. * history of substance abuse or meet criteria for current alcohol abuse or dependence. * center for epidemiological studies depression scale (ces-d) \>27 at screening. meet criteria for sleep apnea, restless legs syndrome or circadian rhythm sleep disorder on the basis of the duke structured interview of sleep disorders (dsisd) or stop-bang is ≥ to 3. * major surgery within 4 weeks prior to first acupuncture treatment.
clinical and radiographic outcomes in arthroscopic "inlay"bristow surgery with screw fixation vs suture-button fixation

Conditions: Shoulder; Dislocation, Chronic

Summary: retrospective comparative case-cohort study to investigate the efficacy of the modified arthroscopic bristow-latarjet surgery and to compare the clinical and radiographic outcomes using screw fixation vs suture-button fixation.

background：some studies have advocated the use of suture-button fixation during bristow-latarjet surgery to reduce complications associated with screw fixation. however, these studies are not comparative studies, and their data are relatively incomplete. purpose: to compare the clinical and radiographic outcomes using screw fixation vs suture-button fixation. study design: retrospective comparative case-cohort study methods: patients who underwent the modified arthroscopic bristow-latarjet surgery between june 2015 and february 2018 were selected. shoulders were separated into two groups based on surgical fixation method. radiological results on 3d ct scan and clinical results were assessed preoperatively, immediately after operation, and postoperatively at 3 months, 6 months, 1 year and during the final follow-up.

Eligibility criteria:
inclusion criteria: 1. a glenoid defect ≥10% 2. contact sport athletes with a glenoid defect \< 10% 3. failure after bankart repair. exclusion criteria: 1. epilepsy 2. multidirectional shoulder instability 3. concomitant other lesions including rotator cuff tear, symptomatic acromioclavicular joint pathology or pathological involvement of the long head of the biceps 4. follow-up was less than 2 years or incomplete follow-up data.
assessment of the effects of pressors on graft blood flow after free tissue transfer surgery

Conditions: Oral Cancer; Head and Neck Cancer; Free Flap; Hypotension

Summary: following surgery to remove tumours of the head and neck, patients undergo reconstruction with free flaps - tissue that is taken from elsewhere in the body and given a new blood supply by attaching it to vessels in the neck. following this type of surgery, patients often need medication to maintain their blood pressure in the intensive care unit. the effect of these drugs on the transplanted tissues is unknown. this study investigates the effects of four commonly used drugs on free flap perfusion.

the optimal sympathomimetic drug to support blood pressure without adverse vasoconstriction of free flap circulation remains unknown. this study examined the effects of four agents (epinephrine, norepinephrine, dobutamine and dopexamine) on free flaps following resection of head and neck cancer. twenty five patients were recruited to the study. each patient received an infusion of the four drugs in a random order with an intervening washout period between drugs, at four infusion rates. continuous free flap skin blood flow monitoring was performed using laser doppler velocimetry, with a second sensor on normal skin acting as a control. global cardiovascular variables were monitored using the lidco rapid pulse contour analysis system.

Eligibility criteria:
inclusion criteria: * patients undergoing free tissue transfer surgery at the john radcliffe hospital wih planned post-operative admission to the intensive care unit. exclusion criteria: * pregnancy * weight \>100kg * contraindications to pressor infusions * overnight ventilation not indicated

Keywords: noradrenaline norepinephrine epinephrine adrenaline dobutamine dopexamine inotrope pressor sympathomimetic free flap transplantation free tissue transfer microsurgery survival
glasgow asthma and allergy study

Conditions: Asthma; Allergy

Summary: in the past, doctors separated people with asthma into two groups, those with "allergic asthma" (about 2/3rds of people) and those with "non-allergic asthma". these labels are not much used now as the treatments for all people with asthma don't depend on this classification. however, new treatments for asthma may become available and the classification may again become important. it could be useful for clinicians to know how to identify which patients are likely to benefit from particular treatments. additionally, some new blood tests are becoming available and some of these might help to categorise the type of asthma people have. what the study hopes to do is to identify patient features which make a diagnosis of "allergic asthma" more likely and to see which new blood tests are most likely to be helpful in confirming this diagnosis.


Eligibility criteria:
inclusion criteria: * male and female patients aged 18 years old and over with a diagnosis of asthma and having received at least two prescriptions for any asthma medication in the last 12 months, who have signed an informed consent form prior to initiation of any study-related procedure exclusion criteria: * under 18 years * current smokers * unwilling or unable to give informed consent * a clinical diagnosis of copd * a history of anaphylaxis (skin prick test) * participated in any clinical study in the last 12 months

Keywords: asthma allergy diagnosis correlation study
eating disorders prevention: an effectiveness trial for at-risk college students

Conditions: Eating Disorders; Obesity

Summary: this three-site effectiveness trial will test whether a brief dissonance-based eating disorder prevention program produces intervention effects when college counselors, psychologists, and nurses are responsible for participant recruitment, screening, and intervention delivery under ecologically valid conditions.

threshold and subthreshold eating disorders affect over 10% of young women and are associated with functional impairment, distress, psychiatric comorbidity, medical complications, mortality, and risk for obesity onset. accordingly, a pressing public healthy priority is to develop effective prevention programs for eating pathology. the proposed project will be the first effectiveness trial to test whether an eating disorder prevention program with strong empirical support from efficacy trials produces effects under ecologically valid conditions among high-risk female college students, which is a vital step toward widespread dissemination of programs developed with nih funding. the proposed cost-effectiveness analyses and examination of process factors that predict larger intervention effects will also represent novel contributions to the literature.

Eligibility criteria:
inclusion criteria: * (1) is a registered student at a participating school, (2) self-reports body image concerns exclusion criteria: * meets dsm-iv criteria for anorexia nervosa, bulimia nervosa, or binge eating disorder

Keywords: eating disorders obesity body dissatisfaction female
european serrated adenoma classification score

Conditions: Colorectal Neoplasms

Summary: the aim of the study is to develop a score system in order to differentiate adenomatous polyps, hyperplastic polyps and serrated adenomas on the basis of optical features. endoscopic images of colorectal polyps will be collected from a prospectively managed database. histopathological diagnoses are available for all polyps. histopathological diagnoses serve as gold standard in this study. in the first phase of the study optical features of serrated adenomas are extracted from the database. discriminators are then defined on the basis of the extracted features. in the second phase a test set of high quality pictures are provided to both novices and experts of colorectal endoscopy. participants are asked to use the above named discriminators in order to rate pictures and to classify polyps into three classes (adenomatous polyps, hyperplastic polyps and serrated adenomas). in the third phase of the study accuracy of optical bases diagnoses is calculated by comparing optically derived diagnoses with histopathological diagnoses (gold standard).


Eligibility criteria:
inclusion criteria: * indication for colonoscopy * patients \>= 18 years exclusion criteria: * pregnant women * indication for colonoscopy: inflammatory bowel disease * indication for colonoscopy: polyposis syndrome * indication for colonoscopy: emergency colonoscopy e.g. acute bleeding * contraindication for polyp resection e.g. patients on warfarin
integration of the 5g-based remote healthcare system in critical care

Conditions: Emergency Medicine; Telemedicine; Augmented Reality

Summary: the primary objective of this initial report is to address the following questions: under what circumstances do clinical teams at satellite locations utilize the 5g rhs? does the implementation of 5g rhs result in significant clinical enhancements? furthermore, additional analyses will be conducted to assess specific improvements in various use cases (e.g., emergency room, diagnosis, treatment, task guidance, and medical education) and to examine whether factors such as the expertise of central physicians, patient and physician locations, and the timing of calls influence clinical outcomes.

background: augmented reality (ar) has undergone rapid development in recent years, gaining prominence in healthcare, especially when coupled with 5g internet technology. this study delves into the integration of 5g augmented reality in emergency medicine, with a focus on its impact on clinical outcomes. methods: this study will utilize the 5g-based remote healthcare system (5g rhs) to connect four satellite emergency room (er) teams with central experts to assess its effectiveness in critical cases. data will be collected from july 2022 to june 2023 to address key research questions, including the circumstances prompting the use of 5g rhs, the extent of clinical improvement achieved, and the influence of central physician expertise, patient and physician locations, and calling time on clinical outcomes.

Eligibility criteria:
inclusion criteria: * 1) age range (≥18 years old). * 2) patients with acute chest pain, stroke and trauma were diagnosed in the departments of emergency medicine of the relevant medical community, branches of run run shaw hospital, zhejiang university school of medicine. * 3) voluntarily participate in the study and sign the informed consent; if the subject does not have the ability to understand or sign the informed consent, his/her guardian will represent him/her in the informed process and agree to participate in the study; if illiterate, his/her will need a witness to witness the knowledge process and his/her will decide to participate in the study. exclusion criteria: * 1) incomplete clinical data. * 2) minors. * 3) pregnant women.

Keywords: teleconference mentoring augmented reality emergency patient outcome
observational, safety study of novonorm® (repaglinide) and insulin analogue combination therapy in type 2 diabetes in korea

Conditions: Diabetes; Diabetes Mellitus, Type 2

Summary: this trial is conducted in asia. the primary objective of this study is to evaluate the clinical safety profile during 26 weeks of novonorm® (repaglinide) and insulin analogue combination therapy in type 2 diabetes under normal clinical practice conditions in korea while the secondary objective is to evaluate the safety and efficacy after 13 and 26 weeks of novonorm® and insulin analogue combination therapy in type 2 diabetes under normal clinical practice conditions in korea.


Eligibility criteria:
inclusion criteria: * informed consent obtained before any study-related activities. (study-related activities are any procedure related to recording of data according to the protocol.) * patients with type 2 diabetes mellitus * patients who are currently treated with novonorm® alone or in combination with metformin or tzd * age: at least 18 years old * patients who will be prescribed with insulin analogue in addition to current novonorm® (with/without metformin/tzd) treatment at the discretion by the physician exclusion criteria: * known or suspected allergy to study product(s) or related products * previous participation in this study. participation is defined as screened * patients who have been treated with insulin preparations (including insulin analogues) previously * females of childbearing potential who are pregnant, breast-feeding or intend to become pregnant or are not using adequate contraceptive methods (adequate contraceptive measures as required by local law or practice) * patients who are unlikely to comply with protocol requirements, e.g. uncooperative attitude, inability to return for the final visit * any other disease or condition that the physician feels would interfere with study participation or evaluation of results
the effect of early iron deficiency on developmental brain and behavior in infants

Conditions: Iron Deficiency

Summary: the purpose of this project to examine brain functions and behavior related to id including sensory ,motor, cognitive and social /emotional functioning, and address unanswered questions about brain and behavior impacts of different timing of id(pre- and /or postnatal id) in infants.

iron deficiency (id) is the most common single nutrient disorder in the world. pregnant women and children before pre-school age are at highest risk. data from animal models provide evidence that early id affected developing brain in specific regions and functions by varies processes include myelination, dopamine neurotransmitter system, and neurometabolism. these impacts appeared differential at different time of brain development and different brain regions, depending on the timing of id. the reversibility of these effects also appeared to depend on the timing of id. this project uses innovative neuropsychologic/ neurophysiologic and behavioral techniques, such as event-related potentials(erp), abr and vep, to study brain functions and behavior related to id including sensory ,motor, cognitive and social /emotional functioning, and address unanswered questions about brain and behavior impacts of different timing of id(pre- and /or postnatal id) in the human infants. this research has the potential to understand reversibility of effects depending on timing of id and treatment as well as basic understanding of mechanism of impact of id in human developing brain. it may also have important implications with regard to policy of interventions for different timing of id, and improve children early development and the quality of population.

Eligibility criteria:
inclusion criteria: * full- term infants exclusion criteria: * prematures, * perinatal high risk infants(asphyxia,infection etc.), * maternal alcohol, * smoking, * drug abuse, * inherited diseases

Keywords: iron deficiency brain cognition behavior
randomized study of ph-10 for psoriasis

Conditions: Psoriasis

Summary: ph-10 is an aqueous hydrogel formulation of rose bengal disodium (rb) for topical administration to the skin, and is being studied for the treatment of cutaneous skin disorders, specifically psoriasis and atopic dermatitis. this multicenter phase 2 study of subjects randomized sequentially by center to one of four treatment cohorts will assess efficacy and safety of topical ph-10 applied once daily to areas of mild to moderate plaque psoriasis.


Eligibility criteria:
inclusion criteria: * men or women, age 18 or older. * presence of mild to moderate plaque psoriasis on the trunk or extremities (excluding palms, soles, scalp, and facial or intertriginous areas). * fitzpatrick skin type i-vi. * written informed consent by the subject or legal guardian. exclusion criteria: * female subjects of childbearing potential who are pregnant, attempting to conceive, not using effective contraception, or who are nursing an infant. * subjects who have received psoralen plus ultraviolet a (puva) therapy or systemic antipsoriatic therapy (immunosuppressants, cytostatics, corticosteroids) within 28 days of study initiation (two weeks for methotrexate). * subjects who have received ultraviolet b (uvb) light therapy within 14 days of study initiation. * subjects who have received topical antipsoriatic therapy (including corticosteroids, tar, anthralin or vitamin d analogs) to the study plaque areas within 14 days of study initiation. * subjects who have received agents posing a clinically significant risk of photosensitivity reaction within 5 half-lives of study initiation. * subjects who have received any approved or investigational biologic drug therapy for psoriasis within 90 days or 5 half-lives of study initiation. * subjects who have participated in a clinical research study within 28 days of study initiation. * subjects with a history of porphyria, systemic lupus erythematosus or xeroderma pigmentosum. * subjects with clinical conditions that, in the opinion of the investigator may pose a health risk to the subject by being involved in the study or detrimentally affect regular follow-up of the subject.
nurse-administered, gut-directed hypnotherapy for patients with irritable bowel syndrome (ibs).

Conditions: Irritable Bowel Syndrome

Summary: adult ibs patients with symptoms refractory to standard medical treatment received nurse-administered, gut-directed hypnotherapy. the primary outcome measure was change in gastro-intestinal symptom severity.

ibs patients with symptoms refractory to standard treatment and who were referred to a specialist unit for hypnotherapy, were consecutively included in the study. the patients received gut-directed hypnotherapy given by a nurse trained in cognitive behavioral therapy (cbt) and hypnotherapy. between 2005 and 2015 patients received 8-12 sessions in an individual manner for 12 weeks. from 2016 the treatment was given in a group format. effects of treatment were measured by validated questionnaires at baseline and at various time points during the treatment period, as well as after the completion of the treatment at follow-up 6 months, 1 and 2 years after treatment.

Eligibility criteria:
inclusion criteria: ibs diagnosis. - exclusion criteria: organic gi disease. -
a multiple dose study of pf-04620110 in type 2 diabetes patients

Conditions: Type 2 Diabetes Patients

Summary: pf-04620110 is a novel compound proposed for the treatment of type 2 diabetes mellitus. the primary purpose of this trial is to evaluate the safety and tolerability, and pharmacodynamics, of multiple oral doses of pf-04620110 in t2dm patients.


Eligibility criteria:
inclusion criteria: * male and/or female subjects between the ages of 18 and 60 years; * body mass index (bmi) of \>25.0 kg/m2 and \<40 kg/m2; * subjects must have a historical diagnosis of t2dm in accordance with the ada guidelines; * subjects who have been on well-tolerated and stable doses of metformin exclusion criteria: * recent evidence (6 months prior to screening) or history of unstable major organ disease; * diagnosis of type 1 diabetes mellitus; * current medical history of myocardial infarction, unstable angina, or history of stroke (including tia) within 6 months prior to screening; * treatment with thiazolidinediones (tzds), or subcutaneously administered antidiabetic agents;

Keywords: multiple dose study in type 2 diabetes patients
heart rate sensing and response in persons with anorexia nervosa

Conditions: Anorexia Nervosa

Summary: there are two major goals of this investigation. first, to develop pilot data to justify a larger randomized clinical trial of an intervention designed to train interoceptive signals (is) and interoceptive responsivity (ir) in persons with anorexia nervosa (an). second, the investigators will determine whether persons with an have similar or different is and ir for heart rate while exercising as compared to age and gender matched controls.

the purpose of this pilot investigation is to assess an interoceptive sensitivity and responsivity as it pertains to heart rate during exercise. thirty adults, 18 years and older will be recruited for a cross-sectional comparison of is and ir in the context of exercise.

Eligibility criteria:
inclusion criteria: study participants will include adults with anorexia spectrum disorders and healthy age and gender matched controls. there will be two control groups, one that includes regularly exercising age and gender matched persons and one where controls do not engage in regular exercise. for those with an, the following inclusion criteria must be met: * age ≥ 18 years old * bmi 25 kg/m2 or less * diagnosis of anorexia spectrum disorder * medications: stable use of all medications ≥ three months for age and gender matched controls, the following inclusion criteria must be met: * age ≥ 18 years old * bmi 25 kg/m2 or less * no diagnosis of anorexia spectrum disorder * medications: stable use of all medications ≥ three months * age (+/- 2 years) and gender matched to study participant exclusion criteria: * history of diabetes, heart disease or taking medications for those conditions * history of hypertension (high blood pressure) not controlled with medication * orthopedic limitations, musculoskeletal disease and/or injury * inability to consent * lack of transportation to the duke center for living campus

Keywords: anorexia nervosa exercise healthy adults physical activity