Kornimate/medical-research-clean huggingface dataset:
beijing indoor air purifier intervention study

Conditions: Pulmonary Disease

Summary: this study aimed to assess the impact of air filtration on indoor air quality and cardio-pulmonary health in residents living in high outdoor pollution settings in beijing.


Eligibility criteria:
inclusion criteria: * global initiative for chronic obstructive lung disease criteria (mild to moderate, gold stage i\~ii; * severe to very severe, gold stage iii\~iv) quit smoking for at least 1 year; * a ratio of pre-bronchodilator forced expiratory volume in one second (fev1) to forced vital capacity (fvc) equal to or less than 0.70 and an increase of fev1 with the use of 400μg of albuterol of less than 12% of the pre-bronchodilator one; * no history of asthma or any other active lung disease. * subjects were free from exacerbations for at least 6 weeks. exclusion criteria: * patients with heart pacemaker, * heart failure with bundle-branch block, * recent myocardial infarction (in the last 12 weeks) and * anticoagulant therapy
factors to obstructive granulation tissue formation after ultraflex stenting in benign tracheal narrowing

Conditions: Chronic Obstructive Pulmonary Disease

Summary: this study is aimed to determine factors leading to obstructive granulation tissue formation after placement of self-expandable metallic stent (sems) in patients with benign tracheal diseases.

from august 2001 to september 2007, patients with benign tracheal stenosis who underwent endoscopic tracheal stent placements at the chang gung memorial hospital, a university-affiliated hospital in northern taiwan, were evaluated. definition of airway conditions dynamic collapse (tracheao-malacia) was defined as tracheal lumen narrowing on expiration under bronchoscopic examination. structural tracheal stenosis was defined as tracheal stenosis excluding dynamic collapse. etiologies of structural tracheal stenosis were post-intubation or tracheostomy, post-tuberculosis infection, granulation tissue formation cause previous sems re-stenosis, previous sems fracture, corrosive injury with stricture, mediastinitis cause airway stricture, and goiter compression. obstructive granulation tissue formation after sems implantation was defined as granulation tissue obstructing the lumen of the sems under bronchoscopic examination, including the proximal and distal ends. significant variables, such as structural obstruction airway before sems implantation was entered into a forward logistical regression analysis to determine the net effect of each predictor while controlling the net effects of others to obstructive granulation tissue formation. obstructive granulation tissue formation curves between patients with and those without structural tracheal stenosis before sems implantation were compared by log rank test.

Eligibility criteria:
inclusion criteria: * age \> 18 years, * benign tracheal obstruction, * receive ultraflex metallic stent placement under flexible bronchoscopy. exclusion criteria: * malignant diseases, * feasibility to receive surgical treatment or silicon stent placement.

Keywords: granulation tissue benign tracheal stenosis ultraflex copd
west-koast study: wes analysis of testicular cancer patientsand their first-degree family members

Conditions: Testicular Cancer

Summary: the project aims to identify the possible risk factors regarding the onset of the disease and to evaluate genes and gene modifications responsible for the onset od testicular cancer.

testicular tumor represents a relatively rare disease that hit young-adults men. it represents 1% of all male cancers and 5% of all urological male tumors. its incidence grow year by year. in the field of the oncological research, the lack of knowledge about genes related to this disease represent a very relevant clinical question. for this reason this project aims to collect biological samples of saliva from testicular cancer patients and from their first-degree family members; demographic-clinical variables will be also collected in order to draft a comprehensive panel of genes and gene modifications related to the testicular cancer, combining this survey with a very detailed description of this cohort of patient in terms of clinical features and quality of life.

Eligibility criteria:
inclusion criteria: * male testicular cancer patients with an age \> 18 and \< 90 * first degree family members of male testicular cancer patients with an age \> 18 and \< 90 * ability to read and sign the informed consent * diagnosis of testicular cancer for the experimental group exclusion criteria: * female for the experimental group * second degree family members of male testicular cancer patients * people with an age \ 90 * diagnosis different from testicular cancer for the experimental group incapacity to read and sign the informed consent

Keywords: testicular cancer cancer familiarity genetic male infertility
population pharmacokinetics of amoxicillin in neonates

Conditions: Emergencies

Summary: the objective of neopopi is to conduct a population pharmacokinetic study of amoxicillin in neonates, in order to evaluate and optimize neonatal dose regimen. there will be no change to the medication treatment received by participants. an opportunistic pharmacokinetic sampling approach will be followed: samples will be scavenged from blood or cerebrospinal fluid drawn for routine biochemical tests. in this way, no additional invasive tests will be needed.

* administration of the antibiotic according to the usual procedures for prescribing services: in particular, neither the indications nor the doses nor the methods of administration are fixed by the protocol * opportunistic sampling strategy: no biological samples are specifically collected for the purposes of the study (measurements of concentrations on "bottoms" or "left-over" samples); the performance of this non-invasive sampling strategy has been previously demonstrated in the neonatal population. * micro-analytical method (assay of concentrations on micro-volumes, of the order of 50μl) * population pharmacokinetic analysis

Eligibility criteria:
inclusion criteria: * neonates receiving amoxicillin and blood/csf tests during amoxicillin treatment, as part of their routine clinical care * no parental opposition to the study participation exclusion criteria: • none
unmet supportive care needs in bladder cancer patients undergoing radical cystectomy

Conditions: Bladder Cancer; Urologic Cancer; Surgery

Summary: nowadays, high-quality cancer care is more than just diagnosis and treatment of cancer. healthcare must respond to the specific needs of the patients to provide patient-centered care. to date, research on the unmet supportive care needs in bladder cancer patients undergoing radical cystectomy is scarce. because the needs of the patients may differ according to the phase in the illness trajectory, it is important that prospective research is carried out. research in other cancer populations shows that unmet supportive care needs are negatively associated with health-related quality of life, psychological distress, physical activity and the health literacy of the patient. by incorporating the above factors into this study, we can not only map the unmet supportive care needs of the patient, but also explore possible associations between the variables. since this is the first prospective study on supportive care needs in bladder cancer, this is a hypothesis-generating study.


Eligibility criteria:
inclusion criteria: * age is 18 years or older * patients diagnosed with bladder cancer who will undergo radical cystectomy * patient has to be able to sign informed consent exclusion criteria: * metastatic cancer * presence of a second primary tumor with the exception of fully deleted prostate cancer, non-melanoma skin tumor or tumor diagnosed ≥ 5 years ago and under control

Keywords: supportive care prospective observational study
a research study of greater occipital nerve block as a treatment for acute migraine attacks

Conditions: Migraine

Summary: several observational studies have shown improvement in episodic migraine with the use of greater occipital nerve block as an acute therapy, and a recent placebo controlled trial did not show a decrease in frequency of episodic or chronic migraine; however, there has never been a placebo controlled trial to investigate the efficacy of gonb as an acute treatment for headache, and there has been no determination of guidelines for selection of patients who would be most likely to respond to gonb. in light of the above, the investigators propose a double-blind, placebo-controlled, randomized trial examining the use of gonb with lidocaine/bupivocaine in patients with an acute episodic migraine. the results of this trial are expected to guide more appropriate therapeutic management of these participants and the optimal use of this procedure. 50 subjects will be entered into this study. this study is being conducted at thomas jefferson university only.


Eligibility criteria:
inclusion criteria: * between the ages of 18 and 80 years old (inclusive) with a previous diagnosis fulfilling the international classification of headache disorders (ichd3b) criteria for episodic migraine, presenting to clinic with an acute episodic migraine reported as at least a moderate pain level not lasting longer than 7 days at the time of injection. exclusion criteria: * subjects who have received greater occipital nerve block (gonb) in the past, subjects who in their own or the investigator's opinion are unable to describe their symptoms, subjects who have are scheduled to receive injection of onabotulinum toxin a within 72 hours, subjects who are pregnant or lactating.
long-term safety of pharmaceutical grade synthetic cannabidiol oral solution in pediatric participants with treatment-resistant childhood absence seizures

Conditions: Childhood Absence Epilepsy

Summary: the primary purpose of this study is to assess the long-term safety and tolerability of cannabidiol oral solution (cbd) in pediatric participants with treatment-resistant childhood absence seizures.


Eligibility criteria:
inclusion criteria: 1. completed all activities through visit 6 (end of study) of ins011-17-103. 2. participant and/or parent(s)/caregiver(s) fully comprehend the informed consent form (icf) and assent form, understand all study procedures, and can communicate satisfactorily with the investigator and study coordinator, in accordance with applicable laws, regulations, and local requirements. 3. a female participant is eligible to participate in the study if she is premenarchal, or of childbearing potential with a negative urine pregnancy test at the screening visit. if sexually active, she must agree to either complete abstinence from intercourse or use acceptable methods of contraception throughout the study and for 4 weeks after completion of study participation or discontinuation from investigational product. 4. a sexually active male participant or partner of enrolled participant must be willing to use acceptable methods of contraception throughout the study and for 4 weeks after completion of study participation or discontinuation from investigational product. 5. in the opinion of the investigator, the parent(s)/caregiver(s) is (are) willing and able to comply with the study procedures and visit schedules, including venipuncture, and the visit schedules. exclusion criteria: 1. participant or parent(s)/caregiver(s) have daily commitments during the study duration that would interfere with attending all study visits. 2. experienced an anoxic episode related to study drug requiring resuscitation during their previous study. 3. developed an adverse event thought to be related to cbd in the previous study and for whom the investigator determines that continuing treatment with cbd would not be in the best interest of the participant. 4. evidence of other clinically significant disease such as unstable hepatic, hematological, renal, cardiovascular, gastrointestinal, immunological, or pulmonary diseases or ongoing malignancies. 5. compromised respiratory function or severe respiratory insufficiency. 6. clinically significant abnormal laboratory values within the past 14 days. 7. in the opinion of the investigator, the participant is unsuitable in any other way to participate in this study.
relationship between right atrial volume index, functional capacity and inflammatory biomarkers in patients with copd.

Conditions: COPD; Right Heart Failure

Summary: right ventricular (rv) dysfunction is associated with increased morbidity and mortality in patients with chronic obstructive pulmonary disease (copd). assessment of rv function by echocardiography is challenging. easy visualization of the right atrium (ra) by echocardiography , allows quantitative, highly reproducible assessment of ra volume. the aim of the present study is to evaluate the relationship between the right atrial volume index (ravi) and functional capacity in patients with copd , quantified by the copd assessment test (cat) questionnaire as an early predictor of right heart affection.

1. approval will be obtained from research ethics committee of faculty of pharmacy, damanhour university. 2. all participants agreed to take part in this clinical study and provide informed consent. 3. patients who were selected from patients visited chest department or attending chest outpatient clinic of tanta university hospitals, echocardiography was done in the cardiology department.. 4. complete physical and laboratory assessment will be done for all patients. 5. serum samples will be collected for measuring the biomarkers. 6. 150 patients with copd and preserved left ventricular systolic function, ejection fraction (lvef) \> 55% will enrolled. the ra volume calculated by biplane area length method using four chamber view twice and indexed to body surface area (ravi). assessment of rv systolic function was done using tricuspid annular plane systolic excursion (tapse), and peak systolic velocity (s'tri) using tissue doppler imaging at the tricuspid annulus. the functional capacity was assessed by the copd assessment test (cat) questionnaire. 7. for each participant, blood samples were obtained and levels of adiponectin, il-1b, high-sensitivity c-reactive protein and neopterin will be determined in all studied subjects. 8. statistical tests appropriate to the study design will be conducted to evaluate the significance of the results. 9. results, conclusion, discussion and recommendations will be given.

Eligibility criteria:
inclusion criteria - patients included were \> 18 years old of both sexes and left ventricular ejection fraction (lvef) \>55%.the following clinical and demographic parameters were recorded; age, sex, current cigarette smoking was defined as active smoking within the past 12 months. coronary artery disease was obtained by history or previous medical records. exclusion criteria - patients with diagnosis of other respiratory diseases (e.g. asthma, interstitial pulmonary fibrosis , tuberculosis or lung cancer ), ischemic heart disease, congestive heart failure, valvular heart disease and congenital heart diseases, were excluded. other chronic diseases, such as kidney or liver failure and cancer were also excluded.

Keywords: chronic obstructive lung disease. right atrial volume index. functional capacity. adiponectin. hs-crp. il1b. neoptrin.
the effect of remote smbg combined with the application of app on the improvement of t2dm management in the community

Conditions: Diabetes Mellitus, Type 2

Summary: to investigate whether strengthen community diabetes patients self-monitoring of blood glucose can improve the patient's blood glucose control under chinese guidelines for the prevention and treatment of diabetes (cds 2017) and whether this intervention produces health and economic benefits.

this project is a cohort intervention study for randomized controlled trials. community health service centers are the main body of implementing treatment and community diabetes patients are the objects of intervention. 498 t2dm patients with poor blood glucose control (7%\<hba1c≤9.5%) from 4 different community health service centers will be randomized into two groups (strengthen group and control group). strengthen self-monitoring of blood glucose by app is the intervention and its duration is 12 months. follow-up time of this study is 24 months (12 months after the intervention stopped). the diabetes treatment of patients from both groups follows chinese guidelines (cds 2017).

Eligibility criteria:
inclusion criteria: * diagnosis of type 2 diabetes * between 18 and 79 years old * 7.0%\<hba1c ≤ 9.5% * routinely uses a smart phone * capability of operating the designated app * long-time residents in jiading district, shanghai, china * subordinated to shanghai medical insurance * contracted residents of community in jiading district, shanghai, china * being cognitively able to participate * provision of written informed consent exclusion criteria: * type 1 diabetes, gestational diabetes mellitus or other types of diabetes mellitus * currently pregnant or contemplating pregnancy within the next 24 months * lactating women * was not able to insist until the end (24 months) * cognitive impairment * migrant population
lifetech ceraflex™ asd closure system post-market clinical follow-up

Conditions: Atrial Septal Defect

Summary: the objective of this post-market registry is to assess the clinical use of the lifetech ceraflex™ closure system in a real-world and on-label fashion.

the study intends to collect data from patients who have implanted with the device between 2019 and 2022. the data collection process is expected to complete by end of 2024. final report shall be available in 2025.

Eligibility criteria:
inclusion criteria: 1. patients with a confirmed diagnosis of atrial septal defect (asd) and implanted with the investigational device as per ifu instructions. 2. patients or legally authorized representatives have signed data release consent or equivalent documents. exclusion criteria: patients did not conduct any follow up visit after hospital discharge.

Keywords: lifetech atrial septal defect asd ceraflex asd closure system
inside: intervention in nutritional supplementation to improve cognitive decline in elderly.

Conditions: Cognitive Dysfunction, Cognitive Disorder; Dietary Supplements

Summary: this study investigates the effect of nutritional supplementation on cognitive performance in older adults over a 90-day period using a double-blind randomized controlled design. the study includes 50 participants, aged 65 or older, randomly assigned to either a supplement group or a placebo group. participants will be randomly assigned to either the experimental or control group. assessments will be conducted pre- and post-intervention to determine the effect of the supplementation on cognitive performance. key outcomes include cognitive status measured by moca, adherence to supplementation, and potential side effects. the findings will provide insights into the potential role of nutritional interventions in mitigating age-related cognitive decline.


Eligibility criteria:
inclusion criteria: * inclusion criteria: community-dwelling adults aged 65 years or older evidence of mild cognitive decline (score \< 26 on the montreal cognitive assessment - moca) ability to provide written informed consent willingness and ability to comply with study procedures and attend scheduled evaluations - exclusion criteria: diagnosis of dementia or any neurodegenerative disease (e.g., alzheimer's, parkinson's) epilepsy and neurologically related conditions severe sensory deficits (e.g., profound visual or hearing impairment) that impair cognitive assessment current use of cognitive-enhancing medications or supplements that cannot be discontinued history of allergy or intolerance to components of the nutritional supplement unstable chronic medical conditions (e.g., uncontrolled diabetes, heart failure, renal insufficiency) participation in another clinical trial in the previous 3 months

Keywords: cognitive decline mild cognitive impairment aging nutritional supplementation
mri-guided stereotactic body radiation therapy in treating patients with liver metastases or liver cancer

Conditions: Adult Hepatocellular Carcinoma; Metastatic Malignant Neoplasm in the Liver

Summary: this pilot clinical trial studies magnetic resonance imaging (mri)-guided stereotactic body radiation therapy (sbrt) in treating patients with liver metastases or liver cancer. sbrt is a specialized radiation therapy that delivers a single, high dose of radiation directly to the tumor and may kill more tumor cells and cause less damage to normal tissue. combining mri with sbrt may help doctors to highlight the tissues surrounding the tumor better.

primary objectives: i. to assess the feasibility of utilizing an mri-guided tri-60co teletherapy system for liver sbrt, as determined the treating radiation oncologist's ability to accurately visualize and align to the target lesion(s). ii. to assess the feasibility of using a three versus five fraction scheme, for one versus multiple (i.e., =\< 5) target lesions. secondary objectives: i. to determine the tumor local control (lc), disease specific survival (dss), and overall survival (os). ii. to gather biomarkers that may elucidate differential immunogenic responses from the three versus the five fraction sbrt regimens. outline: patients undergo mri-guided tri-60co teletherapy sbrt 3-5 fractions over 1-2 weeks. after completion of study treatment, patients are followed up at approximately 4-6 weeks, and then every 3 months for 2 years.

Eligibility criteria:
inclusion criteria: * patients may have either metastatic lesions from another primary site or primary hepatocellular carcinoma; patients with one histologically confirmed metastatic lesion of the liver who are presenting for local therapy for lesions concerning for metastases that cannot or should not be biopsied will also be considered for enrollment on a case by case basis; patients can simultaneously receive treatment for multiple hepatic lesions meeting the prior two requirements, at the discretion of the treating radiation oncologist * karnofsky performance status (kps) \>= 70 * no active infections requiring systemic antibiotics * if a woman is of childbearing potential, a negative urine or serum pregnancy test must be documented; women of childbearing potential must agree to use adequate contraception (hormonal or barrier method of birth control; or abstinence) for duration of study participation and for up to 4 weeks following the study * ability to understand and willingness to sign a written informed consent exclusion criteria: * pregnant women, or women of childbearing potential who are sexually active and not willing/able to use medically acceptable forms of contraception for the entire study period and for up to 4 weeks after the study * refusal to sign the informed consent * patients who are participating in a concurrent treatment protocol * patients for whom a plan meeting institutional quality criteria cannot be designed for sbrt treatment via the mri-guided teletherapy unit, but for whom an sbrt plan meeting institutional quality criteria can be designed for a conventional linear accelerator