Kornimate/medical-research-clean huggingface dataset:
ibuprofen versus acetaminophen vs their combination in the relief of musculoskeletal pain in the emergency setting

Conditions: Pain

Summary: the purpose of this study is to determine whether the combination of ibuprofen and acetaminophen, is more effective than either single agent alone in treating pain from acute musculoskeletal injuries in the emergency department.

the purpose of this study is to determine whether the combination of ibuprofen and acetaminophen, is more effective than either single agent alone in treating pain from acute musculoskeletal injuries in the emergency department. we hypothesize that the combination will be more effective than either agent alone in patients presenting to the emergency department with acute pain from musculoskeletal injuries such as sprain, and bruises. while each agent alone is effective to some degree, many patients do not find complete relief with them and often narcotic agents (with all of their potential side effects) are added. in this study patients experiencing any pain will be randomly given either ibuprofen or acetaminophen or their combination and their degree of pain severity will be measured every 15 minutes up to one hour. at the end of this 1 hour patients still experiencing pain and requiring additional pain relief will receive additional analgesics at the discretion of their treating physician. we will not only measure how much the pain severity was reduced but also the percentage of patients that require some form of additional or "rescue" medication.

Eligibility criteria:
inclusion criteria: * adult patients who presented to the emergency department with pain (a verbal numeric pain score greater than 0 on a scale of 0 to 10 from none to greatest) secondary to an acute musculoskeletal injury of less than 24 hours of duration when one of the study investigators was present were eligible for enrollment exclusion criteria: * patients who had taken an opioid containing analgesic as well as those with a prior history of allergy or contraindications to ibuprofen or acetaminophen.

Keywords: musculoskeletal pain acetaminophen ibuprofen
pharmaceutical care service in diabetes

Conditions: Diabetes Mellitus, Type 2

Summary: the purpose of this study is to examine the effectiveness of pharmaceutical care service in the management of poorly controlled type 2 diabetes mellitus.


Eligibility criteria:
inclusion criteria: patients who visit endocrinology and metabolism department of pusan national university hospital, are with type 2 diabetes mellitus, and meet one of the following criteria * who are diagnosed with type 2 diabetes mellitus for the first time * who need the education for medication or disease * who are with poorly controlled blood glucose * who have poor medication adherence * who have been hospitalized with diabetes complication or poorly controlled blood glucose * whose physician recommend the pharmaceutical care to them exclusion criteria: patients who meet one of the following criteria * who are with gestational diabetes * who are not able to respond to questionnaires * who are with severe condition such as cerebrovascular disease, mental disorder, and acquired immune deficiency syndrome * who are not able to be followed-up during 9 months in pusan national university hospital

Keywords: diabetes mellitus, type 2 pharmaceutical services
primary cell culture of hepatic tumorous cells from routine fine-needle aspiration

Conditions: Hepatocellular Carcinoma

Summary: the purposes of this prospective study were to evaluate the successful rate of primary culture of hepatocellular carcinoma cells and cancer-associated fibroblasts from the residual specimens in routine fine-needle aspiration of hepatic tumor and the potential application of this method as an additional tool for personalized treatment of hepatocellular carcinoma patients.

fine-needle aspiration (fna) cytology or biopsy of hepatic tumor is frequently applied in the collection of specimens because it is considered safe, efficacious, accurate and cost effective. our previous study from small number of patients showed that specimens obtained from fna had potential to be applied for primary culture of cancer cells. this study was to modified our method for primary culture of both hepatocellular carcinoma cells and cancer-associated fibroblasts in patients with tumor measuring larger than or equal to 3cm. all patients received one session of aspiration for the diagnosis of hepatic tumor. the aspirated specimens were applied for both cytologic and pathologic examinations at first. after then, 10 ml 0.9% nacl was aspirated by the same needle connected with the same syringe and injected into 15 ml sterilized centrifugation tube. if the tube contained visible specimens, these specimens were sent for primary culture.

Eligibility criteria:
inclusion criteria: * patients had residual aspirated specimens for primary culture. exclusion criteria: * patients did not have residual aspirated specimens for primary culture.
profile and regulatory network of exercise in improving metabolic phenotypes of patients with prediabetes

Conditions: Prediabetes

Summary: this study is a single-arm, self-control, single-center study to investigate the molecular mechanism under exercise improving metabolism of patients with prediabetes. 40 overweight/obese patients with prediabetes will be recruited in this study and instructed to participate in an 8-week exercise program. we aim to investigate 1) the changes of clinical phenotypes such as body weight, body fat, laboratory values, and resting energy expenditure before and after exercise 2) the changes of peripheral blood mononuclear cell by single cell sequencing 3) search for potential biomarkers of exercise in improving metabolism through multi-omics integrated analysis of single-cell transcriptome, phenomics, metabolomics, etc.


Eligibility criteria:
inclusion criteria: 1. han chinese 2. 5.6 mmol/l≤fasting blood glucose\<7 mmol/l, and/or 7.8 mmol/l≤2h-postload glucose\<11.1mmol/l, and/or 5.7% ≤hba1c\<6.5% without anti-hyperglycemic medicine treatment 3. voluntary participation and provide informed consent exclusion criteria: 1. participated in any clinical study in relation to weight-loss in the past 1 year 2. had a weight change of more than 10% present weight in the past 1 year 3. had a drug usage not suitable for this study in the past 3 months, such as hormone drug, orlistat, metformin, glp-1 receptor agonists, lipid-lowering agents, liver protection drug, etc 4. presence of diseases influencing glucose and lipid metabolism ,such as hyperthyroidism, hypothyroidism, cushing syndrome, etc 5. poorly controlled blood pressure: systolic blood pressure≥180mmhg, and/or diastolic blood pressure≥100mmhg 6. presence of serious heart, liver, kidney or systemic diseases 7. presence of skeletal and muscular diseases which make it difficult to exercise 8. received any kind of surgery in the past 1 year 9. covid-19 positive or recovery from covid-19 within 4 weeks 10. presence of eating disorders or have a history of eating disorders 11. presence of sleep disorders 12. work in disrupted circadian rhythms 13. pregnancy and breastfeeding women
therasphere for the treatment of unresectable hepatocellular carcinoma

Conditions: Hepatocellular Carcinoma

Summary: therasphere is a medical device containing yttrium-90 (y-90) a radioactive material that has been used to treat liver tumors. when y-90 is put into very tiny glass beads (therasphere), it can be injected into the liver through a blood vessel. this allows a large local dose of radiation to be delivered to the tumor with less risk of toxic effects from radiation to other parts of the body or to healthy liver tissue.

surgical resection of the affected portion of the liver offers the best chance for disease-free survival in patients with hepatoma (hcc). unfortunately, most hepatoma patients present with disease that is not amenable to resection (multifocal disease) or have other medical contraindications to surgery (limited hepatic reserve related to advanced cirrhosis or chronic hepatitis). fewer than 15%1 of hepatoma patients are suitable surgical candidates. the objective of treatment with therasphere is to selectively administer a potentially lethal dose of radioactive material to neoplastic tissue in the liver of patients with hcc. regional therapies for hcc may have several advantages over systemically administered treatments. irradiating a cancer prior to treatment with regional chemotherapy may be more effective than either therapeutic modality alone. therasphere may also be of value as a 'bridging' treatment for hcc patients awaiting a donor organ for liver transplantation.

Eligibility criteria:
inclusion criteria: * patients over 18 years of age, of any race or sex, who have hepatocellular carcinoma of the liver * patients who are able to give informed consent, will be eligible. * patients must have an ecog performance status score of \< or = 2 * must have a life expectancy of \> 3 months * non-pregnant with an acceptable contraception in premenopausal women * patients must be \> 4 weeks since prior radiation or prior surgery and at least 1 month post chemotherapy exclusion criteria: * contraindications to angiography and selective visceral catheterization * evidence of potential delivery of greater than 16.5 mci (30 gy absorbed dose) per treatment of radiation to the lungs * evidence of any detectable tc-99m maa flow to the stomach or duodenum, after application of established angiographic techniques to stop or mitigate such flow (ex. placing catheter distal to gastric vessels) * significant extrahepatic disease representing an imminent life-threatening outcome * severe liver dysfunction or pulmonary insufficiency * active uncontrolled infection * significant underlying medical or psychiatric illness * pregnancy * patients will be excluded if they have pre-existing diarrhea/illness, or if they have a co-morbid disease or condition that would preclude safe delivery of therasphere treatment and place the patient at undue risk.

Keywords: unresectable hepatocellular carcinoma therasphere yttrium-90
countering stimulus-induced alpha-desynchronization to treat tinnitus

Conditions: Tinnitus

Summary: the purpose of the study is to examine the effect of alpha-neurofeedback while subjects listen to a noise on tinnitus.


Eligibility criteria:
inclusion criteria: * duration of tinnitus \>= 6 months and \<= 20 years * subjective tinnitus exclusion criteria: * history of neurological or more than mild psychiatric diseases
deep brain stimulation of the nucleus accumbens as a novel treatment in severe opioid addiction

Conditions: Addiction

Summary: the main objective of this study is to assess the efficacy of bilateral deep brain stimulation (dbs) of the nucleus accumbens (nac) as a novel treatment in severe opioid addiction. the included patients have been treated so far with a substitute in form of methadone. our hypothesis is that bilateral dbs of the nac will significantly reduce the craving for heroin and thus enable the patients to decrease their levomethadone-dosage substantially.


Eligibility criteria:
inclusion criteria: * age \> 18 years * proficiency in the german language * long lasting heroin addiction (fulfilled diagnostic-criteria according to dsm-iv,icd-10) * at least one detoxication-treatment without a long-term period of abstinence has already taken place * long-term inpatient treatment to support abstinence have occurred * free patient's decision / informed consent (existing comprehensive ability in meaning, methodology and execution of the study and ability of acceptance) * if prior medication, stable dosage of psychopharmacological drugs over the last three months, which shall, after checking be retained during the study * substitution treatment with constant dose within the last three months before study inclusion exclusion criteria: * hospitalization by psychkg * clinical relevant psychiatric comorbidity (schizophrenic psychoses, bipolar affective diseases, severe personality disorder) * contraindications of a mri-examination, e.g. implanted cardiac pacemaker/ heart defibrillator * current and in the last six months existent paranoid-hallucinated symptomatology * foreign aggressiveness in the last six months * verbal iq \< 85 (evaluated with the german mehrfachauswahl-intelligenz-test (mwt-a/b)) * stereotactic respectively neurosurgical intervention in the past * neoplastical neurological diseases * contraindications of a stereotactic operation, e.g. increased bleeding-disposition, cerebrovascular diseases (e.g. arteriovenous malfunction, aneurysms, systemic vascular diseases) * serious and instable organic diseases (e.g. instable coronal heart disease) * tested positively for hiv * pregnancy and/or lactation
to identify and evaluate the predictive factors for depression in patients diagnosed with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: this is an observational, non controlled, multicentric, prospective study planned to be conducted in 350 subjects diagnosed with multiple sclerosis (ms) in 20 centres of argentina to identify the predictive factors leading to depression. the incidence of depression symptoms and its influence in the evolution of the disease are unknown in the argentinean population. early diagnosis of depression symptoms allows the specific treatment of them and can also delay the rich apparition of the disease. this study intends to quantify the incidence of these symptoms and also aims to evaluate which are the predictive factors of the apparition of the depression.

multiple sclerosis is a chronic, demyelinating disease of the central nervous system and is considered to be one of the most common cause of neurological disability in young adults. the clinical and pathophysiological characteristics of the disease lead to the association of several conditions over time, among which the depression and/or the depression symptoms are one of the most important ones. the underlying mechanism of depression is not clear and the etiology of depression is considered to be multifactorial and especially associated to the psychosocial stress, to the presence of focal demyelinating lesions and to the immune malfunction. several scales like beck depression inventory fast screen (bdi fs), mini mental state examination (mmse), hamilton depression rating scale (hdrs) have been used to objectify the presence of depression symptoms in subjects with ms. objectives primary objective: * identification of the predictive factors for the development of depression symptoms in subjects with ms in argentina secondary objective: * evaluation of the proportion of subjects that develop depression symptoms during the follow up the subjects will be managed with the clinical and therapeutic elements that the treating doctors considered appropriate, without modifying their decisions due to the subjects' inclusion into the study.

Eligibility criteria:
inclusion criteria: * subjects aged between 18 65 years of both sexes * subjects with established ms diagnosis according to the revised mc donald criteria - 2005 in any of its clinical forms * subjects with signed informed consent * subjects wiling to follow the study procedure exclusion criteria: * subjects with diagnosis of depression at the moment of the initial evaluation * subjects receiving antidepressant drugs at the moment of the initial evaluation * subjects with moderate or severe cognitive impairment * antecedents of any other psychiatric disease * subjects that were receiving or have received any experimental treatment during the 6 months before the inclusion

Keywords: multiple sclerosis depression
comparison of patient work of breathing and tidal volumes with high flow nasal cannula oxygen therapy and niv (non-invasive ventilation) after extubation in the icu.

Conditions: ICU; Extubation; Non-invasive Ventilation; High-Flow Nasal Oxygen Therapy; Respiratory Effort; Work of Breathing; Tidal Volume

Summary: this study is aimed at evaluating patient work of breathing and tidal volumes with three methods of oxygenation: standard oxygen, high-flow oxygen therapy and non-invasive ventilation.


Eligibility criteria:
inclusion criteria: * minimum age: 18 years * planned extubation decided by the physician in charge of the patient after success of weaning trial * patients at high risk of reintubation according to the following criteria: patient older than 65 years, or those having any underlying chronic cardiac or lung disease * hypoxemia defined by pao2/fio2 \< 300 mmhg under mechanical ventilation before extubation exclusion criteria: * duration of mechanical ventilation prior to extubation \< 24h * contraindication to niv * contraindication to nasogastric tube * do-not-reintubated order at time of extubation * people under legal protection * opposition to participate
long-term observation of patient engagement in automated insulin delivery

Conditions: Type 1 Diabetes Mellitus

Summary: the purpose of this study is to assess the long-term evolution of patient interaction with the control-iq (tandem™) hybrid closed-loop (hcl) system in individuals with type 1 diabetes over 24 months. specifically, the study examines user-initiated boluses and carbohydrate announcements to determine whether initially low-engagement users increase their involvement over time or, conversely, whether highly engaged users gradually rely more on automation.

automated insulin delivery (aid) systems have revolutionized type 1 diabetes (t1d) management, offering superior glycemic control and quality of life compared to sensor-augmented insulin pumps or multiple daily injections (mdi). however, current aid systems operate as hybrid closed-loop (hcl) systems, requiring user intervention for meal boluses, including carbohydrate counting and timely insulin administration. control-iq (tandem™) was the second aid system reimbursed by the french national health insurance and is now widely used in france. it combines the tandem™ t:slim insulin pump with dexcom™ g6 continuous glucose monitoring (cgm), adjusting basal insulin every five minutes based on glucose predictions and delivering automatic correction boluses once per hour. despite these automation features, users must still manually initiate meal boluses, and additional correction boluses remain optional. while engagement in carbohydrate counting and timely meal announcements improves metabolic outcomes, real-world data suggest that aid benefits individuals across varying engagement levels. long-term data on patient behavior and engagement, particularly regarding carbohydrate announcements and the ratio of automatic to user-initiated boluses, remain limited. understanding these patterns could reveal whether initially low-engagement users increase involvement over time or whether highly engaged users eventually rely more on automation. this single-center, 24-month observational study will follow all t1d patients treated with control-iq at the centre hospitalier sud-francilien between october 2021 and october 2024.

Eligibility criteria:
inclusion criteria: * patients using the control-iq hybrid closed-loop system with data uploaded to the mydiabby platform at least once between october 2021 and october 2024, affiliated with the diabetology department of chsf. exclusion criteria: * patients with a type of diabetes other than type 1 diabetes. * patients who have objected to the use of their data.

Keywords: type 1 diabetes mellitus automated insulin delivery continuous glucose monitoring carbohydrate counting meal announcement
efficacy and safety of insulin rinsulin® nph compared to humulin® nph in type 2 diabetes mellitus patients

Conditions: Diabetes Mellitus, Type 2

Summary: the study is designed to approve non-inferior efficacy and safety of rinsulin® nph compared to humulin® nph.


Eligibility criteria:
inclusion criteria: * signed written consent * diabetes mellitus type 2 * indications for rinsulin nph / humalog nph treatment * glycosylated hemoglobin (hba1c) level of 6.5 to 12.0 % at screening (both values inclusive) * body mass index (bmi) of 18.0 to 35 kg/m2 at screening (both values inclusive). * female patients of childbearing potential who are willing to use two acceptable methods of contraception, (e.g., intra-uterine device plus condom, spermicidal gel plus condom, diaphragm plus condom, etc.), from the time of screening and for the duration of the trial, through trial completion. exclusion criteria: * age less than 18 years old at screening * pregnant and breast-feeding women * need of administration of glucocorticoid therapy or any other therapy that may influence glucose level * administration of any immunosupressive drugs (cyclosporinum, methotrexatum) * serological evidence of human immunodeficiency virus (hiv), hepatitis b (hbsag), hepatitis c (hcvab) or antibodies to treponema pallidum (syphilis) at screening. * history of hypersensitivity to any of the active or inactive ingredients of the insulin/insulin analogue preparations used in the trial, or history of significant allergic drug reactions. * history of hematological disorders that can affect the reliability of hba1c estimation (hemoglobinopathies, hemolytic anemia, etc.). * history or presence of a medical condition or disease that in the investigator's opinion would embarrass glycemic control and completion of the study * presence of severe diabetes complications * receipt of another investigational drug in the 3 months prior to screening * acute psychiatric disorder or exacerbation of chronic psychiatric disorder at screening * history or presence of drug abuse * positive test for addictive substance in urine at screening

Keywords: diabetes mellitus insulin
coffee consumption and pregnancy

Conditions: Coffee; Pregnancy

Summary: coffee, tea, and cocoa contain caffeine, a plant alkaloid. they are frequently consumed during pregnancy. we examined the effect of coffee consumption on fetal renal artery blood flow and amniotic fluid index (afi) in the third trimester of pregnancy

this cross-sectional study occurred in a tertiary center with volunteer pregnant women who agreed to drink coffee. in healthy pregnant women with isolated borderline oligohydramnios, afi and fetal renal artery blood flow indices were evaluated before and after coffee consumption. sixty three patients for the borderline oligohydramnios group (the study group) were included in this study. these patients were compared with 63 healthy pregnant women who had normal amniotic fluid volume (the control group)

Eligibility criteria:
inclusion criteria: * pregnant women with a singleton, uncomplicated pregnancy between the 34th and 37th weeks of gestation were included in this study during routine antenatal examinations exclusion criteria: * abnormal amniotic fluid volume (afv), any intake of nutrient or fluid within the 4 hours previous to ultrasonographic examination \[10\], abnormal doppler blood flow, hypertension, preeclampsia, chromosomal anomaly, intrauterine growth restriction, fetal anomaly, collagen vascular disease, ruptured fetal membranes, and multiple pregnancies.

Keywords: amniotic fluid index caffeine coffee oligohydramnios