Kornimate/medical-research-clean huggingface dataset:
comparison of interventions to promote health in workers

Conditions: Health Behavior

Summary: the goal of this research was to investigate different intervention strategies in the workplace and their impact on quality of life of workers from companies in the city of londrina, parana, brazil. the interventions were composed by exercise in the workplace and educational interventions.

the workplace has special features about human behaviors. studies (shepard 1996, pratt 2008) has shown that workers participate of this kind of health promotion programs for various reasons: one reason is the convenience of doing something without having to look for it; another reason is group support, many workers who share difficulties due to their working demands can find support in each other, so that they could change health behavior. furthermore there are patterns of formal and informal communication that can contribute to help more people to become healthier making their environment better. finally, the norms of a corporate behavior can unite the group of workers seeking same objectives. additionally the literature has shown that adults increased workload, job insecurity and pressure to perform tasks (sparks 1997). these facts has been shown that workplace is different from community based interventions and leisure interventions. the outcomes proposed to study are different from other studies since the interventions focus changes in behaviors. sedentary behavior has shown to have 23% of deaths from major chronic disease (who 2002). as the populations rises around the world and with the prolonged life expectancies, the number of people with chronic diseases will raise (who 2006). by having positive changes in health behavior the costs of public health can be reduced. studying different types of interventions and testing its efficacy in different places can help the policy makers to create healthier environments. there are strategies being developed in the workplace, but its efficacy is being challenged. there are some researches that show no evidence to prove the continuity of these interventions and there are evidences proving the opposite, positive changes in clinical outcomes as diabetes, blood pressure and elevated blood cholesterol. in addition some measures as bmi, anthropometric, fitness level have shown good association as prediction of development of chronic disease with low cost (dishman 2004).

Eligibility criteria:
inclusion criteria the inclusion criteria for participation of these study were never participated of and quality of life and health intervention program at work and had an interest in participating in the study. included workers ≥ 18years who had to work in the office position, sitting at the computer most of the work shift. exclusion criteria: temporary workers and freelancers.

Keywords: physical activity occupational health quality of life health promotion
vascular and neuro-inflammatory effects of endurance exercise training in african americans

Conditions: Vascular Health; Autonomic Function

Summary: the purpose of this study is to test the effects of endurance exercise training on arterial structure and function, and to examine potential mechanisms producing changes in arterial structure and function in young (18-35 years of age) african americans when compared to caucasians.

african-americans are at greater risk than caucasians for developing hypertension, cardiovascular disease, stroke and renal disease. this is likely related to arterial dysfunction including greater arterial stiffness, and reduced microvascular reactivity of resistance arteries in african-americans. in addition, african-americans have higher levels of inflammatory markers, and a greater sympathoexcitatory response to various stressors. this imbalance between sympathetic and reduced parasympathetic activation may directly affect vascular function and potentiate a greater inflammatory response, further altering key structural and functional properties of the vascular wall. the overall aim of this proposal is to test the effects of endurance exercise training on arterial structure and function, and to examine potential mechanisms producing changes in arterial structure and function in young (18-35 years of age) african americans when compared to caucasians. we will examine these effects at rest and following a high intensity (maximal cycle ergometry) sympathoexcitation at both pre- and post-intervention time points, since sympathoexcitation may elucidate changes not evident at rest. because african-americans have higher levels of arterial stiffness, lower microvascular reactivity, greater responses to sympathoexcitation, greater levels of inflammatory markers and greater vasoconstrictive tone, we hypothesize that african-americans will show differential responses to exercise training and benefit more compared to a matched group of caucasians.

Eligibility criteria:
inclusion criteria: * subjects in good health with no cardiovascular, metabolic, or inflammatory disease, who do not use cardiovascular medications or antioxidant vitamin supplementation, including use of anti-inflammatory (including aspirin) or steroidal substances in the past 2 months will be inlcuded exclusion criteria: * subjects who smoke, are severely obese (body mass index \> 35 kg/m2), or who have hypertension (blood pressure \>140/90mmhg), diabetes (fasting glucose \>110mg/dl), hyperlipidemia, inflammatory disease (rheumatoid arthritis and systemic lupus erythematosus, etc) or diagnosed cardiovascular disease including, coronary heart disease, hypertension and cardiac arrhythmia or renal disease, will be excluded

Keywords: arterial stiffness endothelial function autonomic function inflammation
study to evaluate the safety and immunogenicity of a pandemic influenza vaccine in adults aged between 18 and 60 years

Conditions: Influenza

Summary: today, the leading contender for the next pandemic of influenza is h5n1, a strain of avian virus. prevention and control of a pandemic will depend on the rapid production and worldwide distribution of specific pandemic vaccines. candidate 'pandemic-like' vaccines must be developed and tested in clinical trials to determine the most optimal formulation and the best vaccination schedule.this study is designed to test in healthy adults aged between 18-60 years the reactogenicity and immunogenicity of one and two administrations of a candidate pandemic h5n1 vaccine formulated from split virus. the vaccines contain different antigen doses . for each dose, adjuvanted vaccine will be compared to the plain vaccine in order to detect the optimal formulation for immunization against the h5n1 influenza strain.


Eligibility criteria:
inclusion criteria: * a male or female between, and including, 18 and 60 years of age at the time of the first vaccination. * healthy subjects as established by medical history and clinical examination before entering into the study. * if the subject is female, she must be of non-childbearing potential. exclusion criteria: * administration of any vaccine during the period starting 15 days before the first administration of the study vaccine and ending 21 after the second one. * administration of an influenza vaccine other than the study vaccines during the entire study period. * chronic administration (defined as more than 14 days) of immunosuppressants or other immune-modifying drugs within six months prior to the first administration of the study vaccine. * any confirmed or suspected immunosuppressive or immunodeficient condition, based on medical history and physical examination * history of hypersensitivity to vaccines. * history of allergic disease or reactions likely to be exacerbated by any component of the vaccine. * acute clinically significant pulmonary, cardiovascular, hepatic or renal functional abnormality, as determined by physical examination or laboratory screening tests. * acute disease at the time of enrolment. * administration of immunoglobulins and/or any blood products within the three months preceding the first administration of the study vaccine or during the study. * lactating women * use of any investigational or non-registered product (drug or vaccine) other than the study vaccine(s) within 30 days prior to the first vaccination, or planned use during the study period.

Keywords: prophylaxis of pandemic influenza
peripheral nerve block in patients with painful diabetic polyneuropathy

Conditions: Painful Diabetic Neuropathy; Neuropathic Pain; Neuropathy;Peripheral

Summary: the purpose of the present study is to evaluate the role of peripheral afferent input for spontaneous pain in painful diabetic polyneuropathy

both peripheral and central changes in the nervous system contribute to the development of painful diabetic neuropathy, but how these changes contribute to the pain generation remains yet to be fully understood. the purpose of this study is to evaluate if a peripheral regional nerve block relieves spontaneous pain in painful diabetic polyneuropathy.

Eligibility criteria:
inclusion criteria: * aged 18 years or older. * probably diabetic neuropathy confirmed using the toronto criteria in a "conservative manner", i.e. three out of three symptoms/signs of neuropathy must be present (sensory neuropathy symptoms, distal reduced sensibility, reduced ankle reflexes) 7. * definite or probable neuropathic pain for minimum the last 6 months * mean pain intensity at \> 4 nrs the last week17. since we expect a large effect of the block it is not necessary to discontinue pain medication. exclusion criteria: * other causes of pain in the same area or other pain that cannot be distinguished from the neuropathic pain. * unable to understand and speak danish. * non-cooperative. * warfarin or other medication that contraindicate regional anesthesia. * infection in the injection area. * allergy to lidocaine. * pregnancy or lactating (fertile women must to show negative pregnancy test or use anticonception). * severe psychiatric disease e.g. severe depression during the last 6 months. * alcohol or drug abuse.
platelet-rich plasma in the sacroiliac joint

Conditions: Sacroiliac Joint Arthritis

Summary: this is a double-blinded study where the injecting physicians and the patients will not know which arm they are randomized to. each participant will be followed up for 6 months following the injection, and will have in office visits at the injection and approximately 2 weeks post injection. they will be called at month 1, 3, and 6 post injection to assess for any adverse events and number of physical therapy hours or changes in medication. at time of injection, 2 weeks post, and 1, 3 and 6 months after they will be asked to answer some questionnaires on pain and function.

sacroiliac joint (sij) pain is a common and significant source of chronic low back pain. it has been broadly defined as pain located in the area of the sij that can be elicited by various pain provocation tests and relieved after infiltration of the joint with local anesthetic. essentially, a patients own blood is collected and spun at varying speeds until it separates into 3 layers, one of which is the platelet-rich plasma. platelet-rich plasma (prp) injections are commonly used in various conditions including chronic tendinopathy, soft tissue injuries, and ligamentous injuries. more recently, there has been a greater interest in examining the efficacy of prp as a treatment for musculoskeletal conditions affecting joints, such as osteoarthritis (oa). to the investigators' knowledge, there are currently no reported studies evaluating the efficacy of prp for sij pain. given the previously discussed application and evidence behind the use of prp in the knee and hip joints, the investigators propose that prp can also provide a similar solution for treating sij pain.

Eligibility criteria:
inclusion criteria: * aged 18 years and older * sacroiliac/lower back pain * positive block * eligible for steroid injection * positive physical manual assessments exclusion criteria: * steroid allergy

Keywords: prp platelet-rich plasma sacroiliac joint pain sij pain osteoarthritis
comparison of two continuous positive airway pressure systems

Conditions: Obstructive Sleep Apnoea

Summary: randomised crossover trial of a novel and traditional continuous positive airway pressure (cpap) system in obstructive sleep apnoea patients.


Eligibility criteria:
inclusion criteria * participant is willing to provide written informed consent * participant is able to read and comprehend written and spoken english * participant is ≥ 18 years of age * participant has been diagnosed with obstructive sleep apnoea (osa) * participants has been established on continuous positive airway pressure (cpap) for ≥ 6 months * participants is currently using the same mask type/variant as the interventional mask system to be evaluated * participants is able to participate for the duration of the study exclusion criteria * participant is not willing to provide written informed consent * participant is unable to read and comprehend written and spoken english * participant is \< 18 years of age * participant has not been diagnosed with obstructive sleep apnoea (osa) * participant has not been established on continuous positive airway pressure (cpap) for ≥ 6 months * participant is not currently using the same mask type/variant as the interventional mask system to be evaluated * participant is unable to participate for the duration of the study * participant is pregnant * participant is established on bi-level support therapy * participant, or participants bed partner, has metallic implants in head neck or chest * participant has a with a pre-existing lung disease or a condition that would predispose them to pneumothorax (e.g. chronic obstructive pulmonary disease (copd), lung cancer; fibrosis of the lungs; recent (\< 2years) case of pneumonia or lung infection, lung injury) * participant is unsuitable to participate in the study in the opinion of the researcher
effects of sensory flicker and electrical flicker stimulation

Conditions: Brain Diseases

Summary: the study will evaluate whether sensory flicker can modulate neural activity of deep brain regions in humans, and whether it can have relevant effects on behavior. moreover, it will compare those effects to the gold-standard method of modulating brain circuits, direct electrical stimulation of the brain (the same mechanism as deep brain stimulation), using a powerful within-subjects design.

clinical trials have explored the modulation of brain circuits to treat several brain disorders, including parkinson's disease, alzheimer's disease (ad), depression, and obsessive-compulsive disorder (ocd). however, current means to non-invasively modulate brain activity are limited. the study will evaluate whether sensory flicker can modulate neural activity of deep brain regions in humans, and whether it can have relevant effects on behavior. moreover, it will compare those effects to the gold-standard method of modulating brain circuits, direct electrical stimulation of the brain (the same mechanism as deep brain stimulation), using a powerful within-subjects design.

Eligibility criteria:
inclusion criteria: * adult (\>18 years, regardless of gender, race or ethnicity). * to be implanted with intracranial depth or grid/strip electrodes for surgical evaluation. * patient was not shown, during phase i seizure monitoring, to exhibit abnormal eeg activity in response to photic stimulation, and is not clinically suspected to be susceptible to photic-induced seizures. * patient has no pre-existing diagnosis of autism. * patient is not considered at risk for psychogenic nonepileptic seizures (pnes) triggered by sensory stimulation. * fluent in english. * able to understand an informed consent (comprehend potential risks and benefits). * give written and verbal informed consent to all experiments patient would participate in. exclusion criteria: * failure to meet any one inclusion criteria.

Keywords: sensory flicker stimulation electrical flicker stimulation neurophysiological effects behavioral effects brain circuits modulation steady-state evoked potentials
dose finding study to treat high phosphate levels in the blood.

Conditions: Hyperphosphatemia

Summary: randomized. double blind, placebo controlled, parallel arms dose finding study with a 4 weeks treatment period

the study consists of a screening period of approximately 1 week, a wash out period of up to 3 weeks, where existing phosphate lowering medication is withheld, a 4-week treatment period and a follow-up period of up to 2 weeks, during which patients are put back on their pre washout phosphate lowering medication. the wash out period will be either 1 week, 2 weeks or 3 weeks depending on the increase in s-phosphate levels. there are 7 parallel treatment arms in the study with bid and od treatment regimens. laboratory efficacy endpoints and safety assessments will be evaluated at various times throughout the study. the target population of the study is: male or female patients, above18 years of age with end stage renal disease (esrd) on chronic maintenance hemodialysis (hd) 3 times a week for a minimum of 3 months.

Eligibility criteria:
inclusion criteria: 1. females and males aged ≥18 years 2. chronic maintenance hemodialysis 3 x/week for a at least 3 months 3. prescribed and taking at least 3 doses of phosphate binder per day 4. serum phosphate levels should be between 3.5 and 8.0 mg/dl ; 1.13 mmol/l and 2.58 mmol/l (inclusive) at screening 5. total serum calcium levels 2.0 - 2.6 mmol/l inclusive at screening 6. for randomization in the study, after up to 3 weeks wash out of phosphate binders, patients must have serum phosphate levels of at least 6. 0 mg/dl (1.94 mmol/l) but below 10 mg/dl (3.23 mmol/l) and have had an increase of at least 1.5 mg/dl (0.48 mmol/l) vs pre wash out exclusion criteria: 1. severe hyperphosphatemia defined as \>10 mg/dl on phosphate-binders at all time points during clinical routine monitoring for the 3 preceding months before screening visit. 2. serum parathyroid hormone \>1200 pg/ml 3. significant metabolic acidosis 4. clinical signs of hypovolemia at randomization -

Keywords: s-phosphate, hyperphosphatemia, hemodialysis, esrd
effects of percussion therapy on the biomechanics of pickleball movement

Conditions: Injury;Sports; Muscle Soreness

Summary: with increased demand on pickleball as a recreational exercise, it is of interest in investigating the biomechanical characteristics of pickleball and determining the impacts of percussion therapy on them. this study aims to examine the effects of percussion therapy on the biomechanics of pickleball movement and muscle activation patterns in recreational pickleball players. it is hypothesized that kinematics and kinetics of pickleball performance improves after 4 weeks of percussion therapy.

pickleball has rapidly increasing its playing population among people with different ages and performance levels. while pickleball is keeping people of all age active, injury prevalence of recreational pickleball players particularly for elderly populations has rapidly become a great concern in health care in recent years. it is crucial not only for individuals who play the sports but also for sports medicine professionals to prevent injuries and assure wellbeing of pickleball players. percussion therapy with a handheld massage gun has widely utilized both in clinical or sports settings and by individuals as a self-care device, allowing the treatment popular and accessible. while previous research has examined acute effects of percussion therapy, the impacts of percussion therapy on exercise performance are not yet fully understood mainly due to diverse designs, protocols, and qualities of previous studies. moreover, little is known how biomechanical characteristics (i.e., joint kinematics and kinetics) of sports specific movements of pickleball are altered after the percussion therapy. with increased demand on pickleball as a recreational exercise, it is of interest in investigating the biomechanical characteristics of pickleball and determining the impacts of percussion therapy on them. the proposed project aims to examine the effects of percussion therapy on the biomechanics of pickleball movement and muscle activation patterns in recreational pickleball players. it is hypothesized that kinematics and kinetics of pickleball performance improves as well as static joint range of motion (rom) after the percussion therapy.

Eligibility criteria:
inclusion criteria: * age range: 18 - 80 years old * free from injury in lower extremity for the last 6 months * plays pickleball regularly defined as self-reported participation on at least a weekly basis for a year or more exclusion criteria: \* joint injury within previous 6 months

Keywords: kinematics kinetics electromyography
mood and kids diet (make-it) pilot trial

Conditions: Depression - Major Depressive Disorder; Adolescent

Summary: this study is being done to examine the feasibility, including recruitment, retention and acceptability of a randomized controlled trial of a personalized dietary intervention in adolescents with depression. evidence suggests that dietary quality may affect an individual's mood. a healthy diet includes vegetables, fruit, nuts, seeds, and olive oil, as well as minimally processed whole grains, legumes, and moderate amounts of lean meat, fish, and dairy. the investigators will examine the feasibility of testing a personalized nutrition eating plan in a study that uses a randomized controlled trial design for children and youth with depression.


Eligibility criteria:
inclusion criteria: * diagnosis of mdd * center for epidemiological studies depression scale for children (cesd-c) score ≥ 25 at baseline * access to the internet and a computer or smart phone * presence of a parent who is willing to participate exclusion criteria: * adherent to a high-quality diet at baseline * presence of an eating disorder * currently participating in other dietary programs or studies * actively attempting to increase or decrease body weight; * presence of a chronic medical condition; * unstable psychiatric condition (e.g., mania, active suicidal ideation)

Keywords: adolescent diet depression randomized controlled trial pilot