Kornimate/medical-research-clean huggingface dataset:
flow patterns and stent thrombosis

Conditions: Stent Thrombosis

Summary: the goal of this observational study is to study the effect of haemodynamic forces on thrombus formation and identify haemodynamic markers that predict stent thrombosis events in patients who have undergone oct-guided percutaneous coronary interventions. the primary objective of the study is to examine the efficacy of blood flow patterns in predicting stent thrombosis. researchers will compare the blood flow patterns of the stent thrombosis group with that of the control group to understand the influence of blood flow patterns on thrombus formation and progression.

the incidences of stent thrombosis (st) remain high in complex lesions and in high-risk patients. the use of intravascular imaging seems to be able to identify causes of st, enabling prompt correction, and its use has been associated with better clinical outcomes in this setting. however, the efficacy of intravascular imaging features in predicting st is limited. computational fluid dynamic studies have shown that the local hemodynamic forces distribution has an effect on thrombus formation and can be responsible for the st events. however, none of the studies today has explored in vivo the value of the flow disturbances in predicting events. the investigators have recently developed a method that is able to reconstruct vessel geometry accurately using coronary angiography and optical coherence tomography (oct) data. validation of this method in vitro and in human data showed promising results in accurately measuring shear stress and shear rate distribution. this study, aims to explore the value of this method in predicting patients undergoing stent implantation with oct imaging guidance that will suffer a st. the investigators aim to collect data from 40 patients who had an st after oct-guided revascularization and from a control group of 80 patients who had no event after having stent implantation under oct guidance. investigators will further reconstruct the stented vessel from the oct and the angiographic images, perform blood flow simulation and measure the shear rate and the shear stress in these two groups to explore the value of these metrics in predicting stent occlusion.

Eligibility criteria:
inclusion criteria: * patients undergone oct-guided percutaneous coronary intervention and implanted with a second-generation drug-eluting stent * patients who have suffered thrombosis post-stent implantation exclusion criteria: -

Keywords: stent thrombosis endothelial shear stress optical coherence tomography blood flow simulations
shifts in the respiratory microbiome and clinical outcomes of sars-cov-2

Conditions: SARS-CoV-2 Infection; Bacterial Respiratory Tract Infection; Viral Respiratory Tract Infection

Summary: this is a longitudinal, prospective observational study focusing on health-related outcomes relative to potential changes in the respiratory microbiome seen with weekly sars-cov-2 testing in nursing home residents.

this study targets the influence of sars-cov-2, and the presence of mixed/co-infections on the respiratory microbiome. their interrelationship will be characterized in a prospective observational study design. the observed changes will be correlated to medical (fev1, cxr/ct, mortality, morbidity, symptoms) and clinical laboratory parameters (hematology, coagulation, bacterial/viral detection). the study aims at the detection of significant changes in microbiome in the respiratory tract following incidence of sars-cov-2 infection. these alterations in the respiratory microbiome will be determined by shotgun metagenomic sequencing. ultimately, this can provide a better understanding of how sars-cov-2 and the presence of other bacteria and viruses affect the composition of the respiratory microbiome and a description of the microbiological etiology of these respiratory tract infections.

Eligibility criteria:
inclusion criteria: * all residents of the nursing home facility, (m/f) 65 years or above, who have recently tested positive through ohio's parrt program are eligible * resident must submit weekly nasal swab sample per nursing home covid testing guidelines * clinical suspicion of a new episode of acute respiratory tract infection. * laboratory confirmed sars-cov-2 infection by either a laboratory test, pcr or any other commercial or public health test exclusion criteria: * nursing home residents that are not taking part regularly in weekly screening for sars-cov-2 or residents that test negative through ohio's parrt program cannot be included as part of study analyses * residents on hospice, residents currently intubated, residents with scheduled transfer to another nursing home facility will not be included in study analyses

Keywords: nursing home covid-19 respiratory microbiome
neuropathic pain and it's relation to sleep quality in knee osteoarthritis

Conditions: Knee Osteoarthritis; Sleep Disturbance; Neuropathic Pain

Summary: the primary aim is to investigate the frequency and severity of neuropathic pain and its association with night pain in patients with knee osteoarthritis. for this purpose a progressive longitudinal study design was planned. the secondary aim is to investigate the relationship between night pain and neuropathic pain and sleep quality.

osteoarthritis (oa) is the most common form of arthritis in the world. classically, oa presents with joint pain and loss of function; however, the disease is clinically very variable and can present merely as an asymptomatic incidental finding to a devastating and permanently disabling disorder. the severity of knee pain caused by osteoarthritis, often does not correlate with the degree of degenerative changes in the joint. in patients reporting night pain, this may be related to inflammation, but in the absence of clinical and laboratory findings of inflammation, it is not possible to explain night pain only by the degree of joint damage. the existence of a relationship between night pain and neuropathic pain may be a guide in looking for neuropathic pain in patients who have night pain and experience this pain severely and thus for planning an appropriate treatment for the patient. patients with stage 2-4 knee oa will be evaluated in terms of demographic variables and outcome measurement parameters specified in the case report form. the relationship between neuropathic pain scores and knee pain severity will be sought. it will be studied whether there is a difference in outcome measurement parameters between those with neuropathic pain and those without. correlation analysis will be performed between sleep quality score and pain intensity scores. the determinants of sleep quality will be evaluated by regression analysis. american college of rheumatology criteria will be recruited. demographics and disease related variables will be recorded.

Eligibility criteria:
inclusion criteria: 1. having a clinical diagnosis of knee osteoarthritis according to the american rheumatology association/acr criteria 2. knee oa is of kellgren-lawrence stage 2-4 3. the participant gives signed consent - exclusion criteria: exclusion criteria: 1. having diabetes mellitus 2. chronic kidney failure 3. hypothyroidism 4. presence of orthopedic disability (such as implant, prosthesis, contracture, shortness) in the lower extremity 4. neurological diseases that can cause neuropathic pain 5. presence of fibromyalgia 6. malignancy 7. pregnancy 8. neurological deficit in the lower extremity 9. drug use that may cause neuropathy (colchicine, etc.) i̇n the last 3 months 10. drug use (antidepressant, antipsychotic, antiepileptic) due to sleep disturbance or widespread pain in the last 3 months. -
prevalence and characterisation of asthma patients according to disease severity in portugal

Conditions: Asthma

Summary: this study aims to determine the prevalence of asthma, difficult-to-treat and severe asthma in portugal, and characterize patients to better understand their disease characteristics, treatment profile and health care resource use to improve clinical management of the disease.

data on the epidemiology of asthma in portugal were mainly grounded in studies using questionnaires and covering limited age groups. studies assessing the prevalence of asthma diagnosis and of its sub-groups with more accurate methods are therefore needed this study aims to determine the prevalence of asthma, difficult-to-treat and severe asthma in portugal, and to characterize patients to better understand their disease characteristics, treatment profile and health care resource use to improve clinical management of the disease. we will conduct a population-based nationwide study with a multicentre stepwise approach, enrolling 7500 adult subjects, randomly selected, from the portuguese national health service patients' database of 38 primary care centres: stage 0 - phone call invitation and enrolment of participants stage 1 - telephone interview survey to assess respiratory symptoms. stage 2 - clinical assessment, diagnostic confirmation, and patient characterization stage 3 - characterization of asthma patients (sub-group) and characterization of difficult- to-treat asthma \& severe asthma patients after 3 months follow up period.

Eligibility criteria:
inclusion criteria: * adults =\>18 years old registered in portuguese national health service patients' database of primary care units. * give voluntary signed informed consent, * ability to understand ans answer questionnaires. exclusion criteria: * participants that have a physical condition that could interfere with the study assessments or prevent the participant from adequately participating in the study (e.g. mobility problems, not able to perform spirometry,...)

Keywords: asthma severe asthma difficult-to-treat asthma prevalence
physical activity and nutrition intervention in afterschool programs

Conditions: Childhood Obesity

Summary: the investigators long-term goal is to advance the adoption and successful implementation of policies that promote pa and nutrition in after school programs (asp) nationwide. the investigators objective here is two fold. first, the investigators will test the effectiveness of two promising strategies designed to 1) increase the amount of pa children accumulate while attending an asp and 2) promote changes in the nutritional quality of the snacks served. this represents a fundamental step in establishing practice-based guidelines (best practices) for the uptake and achievement of public health policy goals (ca and harvard). second, the investigators will examine the barriers and facilitators to implementing these strategies. the expected outcome of this study is evidence supporting best practices for asps to employ to meet policy goals.

the investigators will use a 3-year delayed treatment, cluster randomized controlled trial design with 20 asps that serve mostly low-income and minority children (approximately 1300 children ages 6-12yrs) in columbia, sc and address the following specific aims: aim 1. evaluate the impact of a staff-level intervention, a professional development training program focused on core competencies to promote physical activity, on children's physical activity levels; aim 2. evaluate the impact of a site-level intervention, a snack modification program that includes a discount buying program, on the quality of snacks served and consumed; and aim 3. evaluate the implementation of the staff-level and site-level interventions and identify organizational, staff, and setting characteristics that influence the process of implementing these strategies.

Eligibility criteria:
inclusion criteria: programs that: * operate immediately after the school day * operate every day of the school year for a minimum of 2 hours * serve a minimum of 30 children of elementary age (6-12 years) * operate in a school, community or faith setting * provide a snack * provide homework assistance/completion time * provide enrichment * provide opportunities for physical activity * all children enrolled, staff, and afterschool program (asp) leaders in the asps were eligible to participate in the study. exclusion criteria: * programs that: * were singularly focused * programs that were physical activity focused children that: * have any physical and/or orthopedic impairment that would limit a child's ability to participate in regular physical activity.
treatment of macrolide-resistant mycoplasma pneumoniae

Conditions: Pneumonia, Mycoplasma

Summary: a randomized clinical trial comparing treatment effectiveness of azithromycin and doxycycline for pediatric mycoplasma pneumonia.

mycoplasma pneumoniae accounts for 10-30% of community-acquired pneumonia (cap) in children. proportionally, m. pneumoniae has become the most important pathogen for childhood pneumonia after the widespread use of streptococcus pneumoniae vaccines. m. pneumoniae is routinely treated with antibiotics, and the macrolides antibiotics are the drug of choice for m. pneumonia infection. however, macrolide-resistance rates have increased to 20 and 100% in asia. in previous studies, the most common mutation point, a2063g, was detected from 23% of local strains in taiwan. the evolution and spreading of mycoplasma in taiwan and different countries are unknown. genotyping based on multiple-locus variable-number tandem-repeat and resistance analysis (mlva) will be used to study the classification and possibly the evolution of m. pneumoniae strains. while the macrolide-resistance is increasing, the optimal therapy remains unclear. both tetracyclines and fluoroquinolones showed promises in treating macrolide-resistant m. pneumoniae in adults. however, their use in children is not recommended due to safety concerns. recently, evidence are accumulating that doxycycline, unlike other tetracyclines, does not cause staining of teeth. in the current study, the investigators are going to carry out a randomized control trial to compare the efficacy and safety of doxycycline against macrolide-resistant m. pneumoniae. on the other hand, the investigators are going to update the macrolide-resistant rates in taiwan and analyze m. pneumoniae strains in taiwan by mlva. by using this rapid and highly discriminatory tool, the investigators could provide more reliable information about the relationship between resistance strains

Eligibility criteria:
inclusion criteria: * children aged 1-18 years, admitted due to lower respiratory tract infections. mycoplamsa pneumonia is diagnosed. * the diagnosis is made within 72 hours after fever onset. * the patient and his/her guardians are willing to participate the study and able to follow the instruction. exclusion criteria: * patients who have already taken macrolides, tetracyclines, or fluoroquinolones. * patient's with congenital or acquired immunodeficiency. * severe patients who needs icu care. * patients or their guardians who are not willing to participate in the study.

Keywords: mycoplasma pneumoniae macrolide-resistance children
a study of aminolevulinic acid used to enhance visualization and surgical removal of brain tumors

Conditions: Malignant Glioma; Glioma; Glioblastoma; Glioblastoma Multiforme; Astrocytoma

Summary: in this study subjects will be administered a single oral dose of aminolevulinic acid (ala) prior to surgical resection of their brain tumor. the ala ultimately causes brain tumor tissue to fluoresce or light up under ultraviolet light. during surgery an ultraviolet light in the microscope chain will be turned on. the tumor tissue will fluoresce bright pink allowing the surgeon to more easily differentiate tumor tissue from normal brain tissue. the aim of the study is to determine whether ala and fluorescent visualization of tumor tissue improves the surgeon's ability to completely resect or remove the brain tumor.

this is a phase 2 study and all subjects will receive open label aminolevulinic acid in a dose of 20mg/kg given orally 3 hours prior to surgery. brain tumors will be resected with the aid of ultraviolet light to visualize the tumor. after surgery an mri will be done to determine whether the tumor has been completely or partially resected. all subjects will be followed for safety. all subjects will be followed closely by clinical examination and by mri to monitor for disease recurrence.

Eligibility criteria:
inclusion criteria: * clinically documented primary brain tumor for which surgical resection is indicated. * age 18 years and older. * ecog performance status less than or equal to 2. * laboratory values as follows: leukocytes greater than or equal to 3,000. anc greater than or equal to 1,500. platelets greater than or equal to 100,000. total bilirubin wnl. ast/alt less than or equal to 2.5 times uln. creatinine wnl. or creatinine clearance greater than or equal to 60ml/min/1.73m2 if scr above institutional normal. -ability to provide informed consent or consent from a legally authorized representative. exclusion criteria: * receipt of an investigational agent within 30 days. * allergy to ala or similar compounds. * personal or family history of porphyria. * uncontrolled intercurrent illness. * inability to comply with the protocol. * pregnancy, breastfeeding.

Keywords: glioma glioblastoma glioblastoma multiforme astrocytoma brain tumor
long-term benefit of aortic stent-graft in patients with distal aortic dissection

Conditions: Aortic Dissection; Aortic Aneurysm; Stent-graft

Summary: background: aortic stent-graft is useful to occlude intimal tear and prevent further dilatation of the false lumen in patients with aortic dissection. the long-term benefit of aortic stent-graft in patients with uncomplicated distal aortic dissection has not been well demonstrated, especially in patients at high risk of aneurysmal change and death. purpose: the purpose of the study is to evaluate long-term clinical benefit of stent-graft insertion performed just after the acute phase into the descending thoracic aorta in patients with distal aortic dissection and at high risk of aneurysmal change of the dissected aorta.


Eligibility criteria:
inclusion criteria: * uncomplicated distal aortic dissection * initial false lumen diameter \>= 22 mm exclusion criteria: * old age (\> 75 years old) * other comorbidity or malignancy with life expectancy \< 5 years * complicated dissection requiring aortic surgery or intervention * sudden death in acute phase * marfan syndrome
wireless micropump in dry eye patients

Conditions: Dry Eye

Summary: the purpose of this study is to carry out a trial to get more convincing and valuable results of the wireless micropump in dry eye patients and compare the outcomes before and after eye drops usage. the investigators hope to investigate the micropump comprehensively, including the comparison of tear film break-up time, corneal epithelium defect percentage, and tear film thickness. to meet the demands of a trial, all the examination equipment should be the same for each patient, and this will limit the variations within a study.

the purpose of this study is to carry out a trial to get more convincing and valuable results of the wireless micropump in dry eye patients and compare the outcomes before and after eye drops usage. the investigators hope to investigate the micropump comprehensively, including the comparison of tear film break-up time, corneal epithelium defect percentage, and tear film thickness. to meet the demands of a trial, all the examination equipment and methods should be the same for each patient, and this will limit the variations within a study.

Eligibility criteria:
inclusion criteria: * elimination of serious mental and psychological diseases; * be accompanied by a parent or guardian who is able to give informed consent as demonstrated by signing a record of informed consent; * be willing to comply with the clinical trial visit schedule as directed by the investigator; * at baseline, be within the age range of 18 to 80 years old inclusive; * bcva≥1.0 of both eyes for each patient; * dry eye test is but\<5s and or schimer test\<5mm/5min； * without other ophthalmic diseases; exclusion criteria: * at the same time, patients with other eye diseases (such as glaucoma, corneal opacity, uveitis, etc.) were diagnosed; * serious mental and psychological diseases; * history of refractive surgery; * nystagmus or failure to cooperate; * history of intraocular surgery; * patients with systemic diseases (such as diabetes, hypertension, heart disease, etc.)

Keywords: micropump dry eye sodium hyaluronate
technical performance assessment of tc-99m tetrofosmin for differentiation of recurrence vs radiation necrosis in patients with glioma

Conditions: Glioma (Diagnosis)

Summary: this study aims to assess the technical performance of tc-99m tetrofosmin spect as compared to f-18 fdg pet for the differentiation of radiation necrosis from glioma relapse and to obtain estimates of diagnostic accuracy for tc-99m tetrofosmin spect and f-18 fdg pet in an intra-individual comparison.


Eligibility criteria:
inclusion criteria: 1. confirmed high grade glioma (e.g., anaplastic astrocytoma, glioblastoma, anaplastic oligodendroglioma, or anaplastic oligoastrocytoma) 2. being in follow-up for at least 3 months after completion of radiation therapy (with or without concurrent chemotherapy) 3. inconclusive mri results regarding the differentiation between recurrence and radiation necrosis 4. willing and able to undergo all study procedures 5. informed consent in writing (dated and signed) exclusion criteria: 1. age: less than18 years 2. if female, pregnant or breast feeding (females of child-bearing potential must use adequate contraception and must have a negative pregnancy test performed within 7 days prior to inclusion into this study) 3. contraindications for tc-99m tetrofosmin 4. contraindications for f-18 fdg 5. close affiliation with the investigational site; e.g. first-degree relative of the investigator 6. participating in another therapeutic clinical trial or has completed study participation in another therapeutic clinical trial within 5 days of enrolment into this trial 7. having been previously enrolled in this clinical trial 8. being mentally disabled 9. mental conditions rendering the subject incapable to understand the nature, scope, and consequences of the trial 10. being clinically unstable or requiring emergency treatment
"unmasking study" for atrial fibrillation recurrences typing in early postoperative period

Conditions: Atrial Fibrillation

Summary: the aim of this study is to identify the most appropriate method for managing patients with af recurrences after the first ablation procedure, through the diagnostic data stored by a subcutaneous af monitor.


Eligibility criteria:
inclusion criteria: * highly symptomatic patients refractory to at least two antiarrhythmic drugs * patients with sustained paf episodes and/or history of persaf interrupted with cardioversion. exclusion criteria: * congestive heart failure * ejection fraction \<35% * left atrial diameter \>60 mm * previous ablation procedure

Keywords: atrial fibrillation percutaneous continous monitoring ablation