Kornimate/medical-research-clean huggingface dataset:
total intravenous anesthesia and inhalation anesthesia

Conditions: Postoperative Complications

Summary: the aim of us is to define the incidence of postoperative complications and recovery time in view of two anesthesia procedures. during the period between 01.01.2016 and 01.01.2017, totally 583 patients were included in the study, who had oral and maxillofacial surgeries. anesthesia types were determined as total intravenous anesthesia (tiva) and inhalation anesthesia (ia). postoperative complications and recovery period were determined as tachycardia, bradycardia, hypertension, hypotension, recovery time, additional analgesia, nausea-vomiting. both anesthesia procedures were compared in terms of these postoperative complications and recovery time.

totally american society of anesthesiologists (asa) i-ii, 18-60 ages, 583 patients who had had oral and maxillofacial operations for 30 minutes and over with tiva and ia methods between 1st jan, 2016 and 1st jan, 2017. the ones who had insufficient data in their files and who were conscious / superficial sedation patients were excluded from the study. the patients were allocated to two groups as tiva and ia. the total intravenous anesthesia group was named "group tiva" , and the volatile anesthesia group was named "group ia". all the patients were opened vascular access after being taken into the operation room and were given anesthesia induction with 1 µg/kg fentanyl, 2 mg/kg propofol and 0,8 mg/kg rocuronium. the patients in group ia were given 1-2% volume sevoflurane in 50% oxygen and 50% nitrous oxide during maintenance of anesthesia, while the patients in group tiva were applied 4-10 mg/kg/h propofol and 0.05-0.1 µg/kg fentanyl iv infusion with 50% oxygen and 50% air. while being woken up, each patient was given 0.3 mg/kg tenoxicam for analgesia and 0.2 mg/kg metoclopramide for nausea-vomiting prophylaxis in a routine way. each patient was taken into recovery room after extubation and pulse rate, non-invasive blood pressure (nibp) and oxygen saturation monitorization were done. postoperative complication and vital finding tracks of each patient were done as usual and were recorded.

Eligibility criteria:
inclusion criteria: * totally american society of anesthesiologists (asa) i-ii, 18-60 ages patients who had had oral and maxillofacial operations for 30 minutes and over with tiva and ia procedures between 1st jan, 2016 and 1st jan, 2017. exclusion criteria: * the ones who had insufficient data in their files and who were conscious/superficial sedation patients were excluded from the study.

Keywords: postoperative pain recovery period total intravenous anesthesia inhalation anesthesia
effectiveness and safety of single lower limb rehabilitation training robot in stroke patients with hemiplegia

Conditions: Hemiplegia

Summary: this trial is a multi center, randomized, controlled, excellent effect, open and loading trial design. the subjects are randomly assigned to the experimental group and the control group. the experimental group adopts litestepper single lower limb rehabilitation training robot walking training on the basis of routine rehabilitation management of stroke patients with hemiplegia, walking training once a day, 40 ± 5 minutes each time; the control group was treated with routine rehabilitation management of stroke patients with hemiplegia. the trial was an open design. both researchers and subjects knew the treatment allocation and conducted three evaluations within 21 days to evaluate the effectiveness and safety of litestepper single lower limb rehabilitation training robot in the training of lower limb motor function of stroke patients with hemiplegia.

by collecting the movement gait information of the patient's healthy side limb, judging the patient's movement intention, analyzing and learning the gait characteristics of the patient's healthy side, so as to drive the movement of the single lower limb rehabilitation training robot and drive the patient's affected side limb to carry out the rehabilitation training suitable for the healthy side limb, which can enable the patient to complete the normal walking process and achieve the purpose of auxiliary rehabilitation. through long-term walking rehabilitation, patients can gradually recover their normal walking gait.

Eligibility criteria:
inclusion criteria: * understand the whole process of the experiment, voluntarily participate and sign the informed consent; * 18-75 years old for both sexes; * stable vital signs, stable condition, tolerance to low-intensity sitting and standing training; ④ weight ≤ 100kg, height 1.50m \~ 1.90m; ⑤ patients with stroke hemiplegia diagnosed as the first onset, including cerebral infarction and intracerebral hemorrhage, the course of disease is within one month after the onset; ⑥ one level of sitting or standing balance, able to wear a single lower limb rehabilitation training robot with the help of medical staff; ⑦ the passive range of motion of hip and knee is not significantly limited, and the passive range of ankle can be kept in neutral position. exclusion criteria: * the range of motion of the joint is severely limited and the walking movement is limited; * skin injury or infection of the lower limb in contact with the robot; * history of unstable angina pectoris, severe arrhythmia and other heart diseases; ④ history of severe chronic obstructive pulmonary disease; ⑤ other contraindications or complications that may affect walking training; ⑥ pregnant women, women preparing for pregnancy or lactation; ⑦ those who participated in any clinical trial within 1 month before enrollment; ⑧ other circumstances that the researcher believes cannot participate in the clinical trial.

Keywords: hemiplegia
a study to evaluate the safety and effectiveness of mirogabalin in chinese adult patients with diabetic peripheral neuropathic pain (dpnp) in real-world clinical practice setting (remission study)

Conditions: Diabetic Peripheral Neuropathic Pain

Summary: this study will evaluate the safety and effectiveness of mirogabalin in adult patients with diabetic peripheral neuropathic pain (dpnp) in real-world clinical practice setting in china.

mirogabalin has been approved in china for the treatment of dpnp. although there is evidence of the safety and efficacy of mirogabalin, there is a lack of real-world evidence on its safety and effectiveness to inform decision-making among a more diverse patient population in real-world clinical practice, such as patients with moderate or severe renal impairment; patients with more complications, comorbidities, and treatments; and patients with different severity of pain. this study aims to collect safety and effectiveness data to guide physicians in the clinical use of mirogabalin for the treatment of patients with dpnp in the real-world clinical practice setting.

Eligibility criteria:
inclusion criteria: patients must meet all the following criteria to be eligible for this study. 1. age ≥ 18 years at the time of informed consent form (icf) signed. 2. patients diagnosed with dpnp (defined as patients diagnosed with type 1 or type 2 diabetes and painful distal symmetric polyneuropathy). 3. patients with a pain scale of visual analog scale (vas( ≥ 40 mm on the day of icf signed. 4. patients who are mirogabalin naïve prior to icf signed and planned to initiate mirogabalin treatment. 5. patients who are able to give signed icf for study participation and willing to provide access to previous and future medical information. patients who meet any of the following criteria will be excluded from this study. 1. patients who have other severe pain unrelated to dpn at baseline, which may confound the assessment of dpnp. 2. patients who previously received pregabalin ≥ 300 mg/day or gabapentin ≥ 1200 mg/day to treat dpnp and declared lack of effectiveness. 3. patients who received pregabalin, gabapentin, crisugabalin, or any other dpnp analgesic medications\* within 7 days prior to icf signed. \*other dpnp analgesic medication includes tcas (amitriptyline, nortriptyline), snris (duloxetine, venlafaxine), antiepileptics (carbamazepine), opioids (tapentadol, tramadol). 4. patients with major psychiatric disorders (depression, alzheimer disease, parkinson disease, mania, bipolar disorder, psychosis, or schizophrenia, etc.) at baseline. 5. patients with contraindications for mirogabalin treatment according to china package insert of mirogabalin. 6. patients with simultaneous participation in any interventional clinical study. 7. female patients at the status of pregnancy, potential pregnancy, or breast feeding. 8. patients who have been judged by the investigator to be unsuitable to participate in the study.

Keywords: diabetic peripheral neuropathic pain real-world evidence mirogabalin
combined effects of ba-duan-jin based deep breathing exercises and forced expiratory technique

Conditions: Chronic Obstructive Pulmonary Disease

Summary: this study will be a randomized control trial. a total of 68 patients will be recruited and randomly assign to the experimental group or the control group in a 1:1 ratio. participants in the experimental group will receive a 8-week ba-duan jin exercise training intervention along with forced expiratory technique at least 3 days a week and 30 minutes a day, while participants in the control group will be only given forced expiratory intervention and will be told to maintain their original lifestyle for 8 weeks along with standard copd treatment.

this study will be a randomized control trial. a total of 68 patients will be recruited and randomly assign to the experimental group or the control group in a 1:1 ratio. participants must have a documented diagnosis of chronic obstructive pulmonary disease (copd) based on established clinical criteria (such as gold guidelines). participants should be between 40 and 55 years old. participants should be in a stable condition, free from exacerbations or respiratory infections for at least four weeks prior to the study enrollment. participants in the experimental group will receive a 8-week ba-duan jin exercise training intervention along with forced expiratory technique at least 3 days a week and 30 minutes a day, while participants in the control group will be only given forced expiratory intervention and will be told to maintain their original lifestyle for 8 weeks along with standard copd treatment. all participants will continue with their prescribed medication. during this study time participants will be given instructions on how to perform the prescribed pulmonary exercises. after each exercise session the fev1 and exercise capacity of the patients will be checked.

Eligibility criteria:
inclusion criteria: * both genders * diagnosis of copd: participants must have a documented diagnosis of chronic obstructive pulmonary disease (copd) based on established clinical criteria (such as gold guidelines) * participants should be between 40 and 55 years old * participants should be in a stable condition, free from exacerbations or respiratory infections for at least four weeks prior to the study enrollment. * participants must be physically able to participate in ba-duan-jin based deep breathing exercises. exclusion criteria: * individuals with significant comorbidities such as asthma, pulmonary fibrosis, bronchiectasis, or lung cancer * participants with severe cardiovascular conditions, such as recent myocardial infarction, unstable angina, or uncontrolled hypertension, which could limit exercise participation * individuals with severe cognitive impairment or psychiatric conditions preventing them from understanding and following the exercise program * individuals with severe physical impairments unrelated to copd, hindering their ability to perform exercises or assessments.

Keywords: pulmonary disease breathing exercises ba-duan jin
interventional study on the impact of the hypnosis used as sedation or relaxation in the breast oncologic surgery

Conditions: Breast Neoplasm

Summary: the aims of the study are to compare the recovering period between a group of patients with conventional sedation, a group using hypnosis as sedation during the surgery and a third group using hypnosis as a relaxation method and preparation but enjoying a classic sedation for their surgery. comparaison of pain ( different types of pain), consumption of pain killers ,anxiety and fatigue on day0,1, 8 after surgery and every. 3 months during the first 2 years of follow up. comparisons are also performed in substudies defined by treatments modalités. inflammatory parameters s ( crp_ c reactive protein, nlr- ( neutrophils to lymphocyte ratio) are measured on day 0, 1, 8 and also salivary immunoglobulins and different endocannabinoids.

hypnosis has already demonstrated benefits among breast cancer patients undergoing oncologic surgery. different side effects were measured during the post operative period and at each follow up visit by physicians in order to carefully compare side effects in the 3 armes of patients.. our hypothesis was that hypnosis sedation generates less perioperative inflammatory reaction. a substudy of 50 patients was also dedicated to the investigation ofsalivary immunoglobulins and dosage of differents endocannabinoids

Eligibility criteria:
inclusion criteria: * patient over 18 years old * signed informed consent form * patient has to be in possession of her administrative laws and affiliated to the social security insurance. * the patient must have a diagnosis of resectable breast cancer (in situ or invasive breast cancer). . surgical procedure must include evaluation of the axillary area (sentinel lymph node biopsy and or axillary dissection) exclusion criteria: * patient under 18 years old * no signed informed consent form * patients who haven't her social security insurance and prisoners are not eligible. * no evaluation of the axillary area. * breast cancer in men
intervention to enhance numeracy in diabetes (intend)

Conditions: Diabetes

Summary: the objective of this project is to test two interventions designed to improve diabetes-related numeracy. numeracy is the ability to understand and use numbers. people with diabetes use numbers in a variety of ways in managing their condition (e.g., understanding blood sugar values, counting carbohydrates, taking medications at the right dose and time). as part of this project, the investigators developed and pilot tested two interventions to improve diabetes-related numeracy: (1) a series of in-person education classes and (2) a one-time, online diabetes education class. the investigators will look to see whether participants in the education classes show improvements in their diabetes-related numeracy skills, self-care behavior and attitudes, and clinical outcomes (i.e., body mass index, blood pressure, blood sugar \[a1c\]).

sixty-five american indians with diabetes were enrolled. each participant was randomly assigned to 1 of 3 study arms: (1) the in-person education group, (2) the online education group, and (3) a control group. the in-person intervention group attended four class sessions addressing numeracy skills used in the management of diabetes (e.g., counting carbohydrates). the online education group completed a single online module providing training on diabetes-related numeracy skills. the control group received written diabetes educational materials. the investigators collected data at baseline, then again immediately after intervention participation (in-person or online classes), and one final time about three months after the conclusion of the intervention. the investigators will conduct analyses to determine if intervention participants experienced positive changes in diabetes numeracy (the primary outcome) as well as several secondary outcome measures following intervention. secondary outcomes include: diabetes knowledge, self-efficacy, outcome expectancies, readiness to change, self-care behavior, and clinical outcomes (i.e., body mass index, blood pressure, blood sugar \[a1c\]) . the investigators also will assess whether change in numeracy predicts change in these secondary outcomes.

Eligibility criteria:
inclusion criteria: * american indian/alaska native; * 18 to 89 years old; * diabetes diagnosis documented in medical records; * active patient of the yakama indian health service. exclusion criteria: * does not speak english; * pregnancy; * dialysis; * current cancer treatment; * blindness; * active alcohol/substance abuse; * planning to move out of the area in the next six months.

Keywords: numeracy health literacy
effect of touch screen tablet on fine motor functions

Conditions: Hemiplegic Cerebral Palsy

Summary: the objective of this study to asses the effect of touch screen tablet on fine motor functions


Eligibility criteria:
inclusion criteria: * hemiplegia * mid spasticity of upper limb * able to follow instructions exclusion criteria: * fixed deformities visual or respiratory problem
long-term durability study of collagenase clostridium histolyticum (cch)

Conditions: Edematous Fibrosclerotic Panniculopathy

Summary: this study will evaluate the long-term safety and duration of efficacy of cch in the treatment of women with cellulite. this study will be a single day evaluation, approximately 48 months after the first dose of study drug was received in the en3835-201.


Eligibility criteria:
inclusion criteria: 1. have participated in and completed studies en3835-201, en3835-202 and en3835-219 and had composite improvement of at least 2 levels on both the cr-pcss and pr-pcss in study en3835-201. 2. be willing and able to cooperate with the requirements of the study. exclusion criteria: 1. has had retreatment with cch in the area initially treated during the en3835-201 study since the completion of study en3835-219. 2. has received collagenase treatments (eg, santyl® ointment and/or xiaflex®/xiapex®) since the completion of study en3835-219. 3. has had liposuction on the body region treated during the en3835-201 study since the completion of that study. 4. has had any surgery, invasive procedure (eg, liposuction), injectable treatment (eg, kybella®) or any similar treatment in the area treated during the en3835-201 study since the completion of that study. 5. has any other condition(s) that, in the investigator's opinion, might indicate the participant to be unsuitable for the study.

Keywords: efp cellulite
hemoglobin-to-red blood cell distribution width ratio and hypothermia for elderly patient

Conditions: Transurethral Resection of Prostate Syndrome; Elderly (People Aged 65 or More); General Anesthetic

Summary: as individuals age, they often enter a phase of increased "frailty." elderly and frail patients represent a population that requires heightened sensitivity and close monitoring during surgical procedures. this study aims to investigate the relationship between the hemoglobin-to-red blood cell distribution width (hb/rdw) ratio and perioperative hypothermia in elderly patients undergoing transurethral prostatectomy. this is an observational study. preoperative blood test results and intraoperative body temperature measurements of the patients will be recorded in our data forms.


Eligibility criteria:
inclusion criteria: * patients who provided informed consent. * patients scheduled for transurethral prostatectomy surgery. * patients classified as asa-ps 1, 2, or 3. * male patients aged 65 years or older. * patients undergoing elective surgery. * patients receiving general anesthesia. exclusion criteria: * patients who did not provide informed consent. * patients undergoing emergency surgery. * patients with conditions that disrupt thermoregulation (e.g., intracranial mass, peripheral vascular diseases, sepsis). * patients with a body temperature of \ 38℃ upon arrival at the preoperative waiting room. * patients who used heating methods other than the routine cotton cover in the preoperative waiting room. * patients who received additional heating methods other than the routinely applied intraoperative hot air blower drapes. * patients undergoing surgery under any type of anesthesia other than general anesthesia. * patients who were taken out of the operating room while intubated.

Keywords: elderly hypothermia
a phase 2 study of the latanoprost punctal plug delivery system in subjects with ocular hypertension or open-angle glaucoma

Conditions: Glaucoma; Ocular Hypertension

Summary: the purpose of this study is to evaluate iop response to experimental dose of latanoprost- ppds in subjects with ocular hypertension or open-angle glaucoma.


Eligibility criteria:
inclusion criteria: * over 18 yrs of age with ocular hypertension or open-angle glaucoma * subjects who have a best corrected visual acuity of 20/100 or better exclusion criteria: * subjects who wear contact lenses. * uncontrolled medical conditions * subjects requiring chronic topical artifical tears, lubricants and/or requiring any other chronic topical medications * subjects who have a history of chronic or recurrent inflammatory eye disease
risk of venous thromboembolism in critically ill patients with severe covid-19

Conditions: COVID-19; Critical Illness; Venous Thromboembolism; Venous Thromboses; Venous Thromboses, Deep; Venous Thrombosis Pulmonary; Pulmonary Embolism; Pulmonary Embolism and Thrombosis; Sars-CoV2; SARS-CoV Infection

Summary: severe covid-19 patients at a high risk of venous thromboembolism. we studied patients in 2 intensive care units of university hospitals in barcelona and badalona, spain. we performed a cut-off screening of deep venous thrombosis (dvt) with bilateral duplex ultrasound to 230 patients.

sars-cov-2 infection has been associated with coagulation disorders and increased risk of venous thromboembolism (vte). the aim of the study is to determine the cumulative incidence of vte in critically ill patients with covid-19 and its impact on prognosis. methods cohort study of critically ill patients due to covid-19. a bilateral venous compression (cus) ultrasound screening of the lower extremities was performed during a cut-off period in 2 intensive care units of university hospitals in spain. asymptomatic and symptomatic vte were registered: pulmonary embolism (pe) (diagnosed by ct-angiography) and deep venous thrombosis (dvt). the characteristics of the patients, results of their blood tests and their evolution after 7 days of follow-up were recorded.

Eligibility criteria:
inclusion criteria: * patients with severe covid-19 pneumonia admitted to the intensive care unit exclusion criteria: * treatment with extracorporeal membrane oxygenation (ecmo) * pregnant or postpartum women * under 18 years old
a study in children with growth failure due to chronic renal insufficiency (cri) or end stage renal disease (esrd)

Conditions: Chronic Renal Insufficiency; End-Stage Renal Disease

Summary: this study is a multicenter, open-label, observational, postmarketing surveillance study that will collect information on the use of genentech growth hormone (gh) preparations to treat children with cri in the united states.


Eligibility criteria:
inclusion criteria: * children diagnosed with cri or esrd and treated with a genentech gh preparation on or after 1 january 2001 * cri documented using the schwartz formula indicates a calculated creatinine clearance (crcl) of \<=75 ml/min/1.73 m\^2 * ability to keep follow up appointments throughout the study exclusion criteria: * subjects receiving a non-genentech gh preparation * subjects with closed epiphyses * subjects with active neoplasia * current participation in another gh clinical study * current participation in the core study