Kornimate/medical-research-clean huggingface dataset:
a study to assess the engagement and usefulness of care4today digital platform for disease management in coronary artery disease (cad) and/or peripheral artery disease (pad) population

Conditions: Coronary Artery Disease (CAD); Peripheral Artery Disease (PAD)

Summary: the purpose of this study is to assess the engagement and usefulness of care4today® connect cad-pad digital platform in participants with coronary artery disease or peripheral artery disease (cad or pad).


Eligibility criteria:
inclusion criteria: * must have a diagnosis of cad and or pad, who are on therapy or about to initiate therapy * own an iphone or android mobile device * have an active email account * must sign a participation agreement or informed consent form (icf) allowing data collection in accordance with local requirements * willing to download and use care4today (c4t) cad-pad application (app) exclusion criteria: * any cardiovascular conditions (for example, recent stroke, high bleeding risk, severe heart failure) or non-cardiovascular condition deemed as poor prognosis by the investigator and which may percent a patient from completing the study * unable to read or write the language used for the c4t (english, or spanish if spanish version is available) * visual or hearing impairment or mental disability that would preclude independent app use * patients currently using the c4t app prior to the signing of icf

Keywords: care4today, coronary artery disease, peripheral artery disease, cad, pad
altered calcium and vitamin d in pmdd or severe pms

Conditions: Premenstrual Syndrome

Summary: osteoporosis has become one of the most widely recognized disorders of our times affecting an estimated 25 million women in this country. recent evidence has suggested that premenstrual syndrome (pms) is associated with a calcium deficiency state and bone loss. this may place premenopausal women at greater risk for osteoporosis. an entity such as pms may be an important physiological marker of a calcium disturbance. the purpose of this investigation is to understand more completely the extent to which calcium balance is disturbed in severe pms or premenstrual dysphoric disorder (pmdd) by utilizing new tools to assess calcium and bone turnover. the long term objective is to elucidate the pathophysiology of pmdd or severe pms as it relates to calcium hormones and bone markers. the experimental design involves the comparison between women witn severe pms and asymptomatic controls.


Eligibility criteria:
inclusion criteria: * medical history of severe pms for the pms group * no medical history of pms for the control group * prospective 2 month documentation of moderate to severe symptoms for the pms group * prospective 2 month documentation of absent symptoms for the control group * general good health * regular menstrual cycles * no history of metabolic bone disease exclusion criteria: * amenorrhea * anorexia nervosa * malabsorption * inflammatory bowel disease * erosive gastrointestinal disease * gastrectomy * malignancy * multiple myeloma * primary hyperparathyroidism * use of suppressive doses of thyroxine * cushing's syndrome * use of glucocorticoids or anticonvulsants * use of diuretics * metabolic bone disease * pregnancy or perimenopause or menopause * mental retardation * menstrual irregularity * significant gynecologic abnormality * use of birth control pills

Keywords: premenstrual dysphoric disorder severe premenstrual syndrome calcium metabolism vitamin d bone markers premenopausal menstrual cycle
prevention of coronary slow flow or no-reflow during ppci in patients with acute stemi

Conditions: ST Segment Elevation Myocardial Infarction; Primary Percutaneous Coronary Intervention

Summary: primary percutaneous coronary intervention (ppci) is the gold standard of treatment of st segment elevation myocardial infarction (stemi).slow flow / no-reflow phenomenon following ppci in stemi patients has been a serious and common complication that closely related to the incidence of major adverse cardiovascular events (mace) and affected patients' prognosis. no reflow is a multi-factorial phenomenon. and its preventive and therapeutic effects are not satisfactory. this prospective randomized controlled study aimed to compare favorable effects of nitroprusside versus tirofiban on the prevention of slow flow / no-reflow phenomenon during ppci.


Eligibility criteria:
inclusion criteria: * ischemic symptoms \< 12h, or evidence of ongoing ischemia 12h after symptom onset * continued ischemic chest pain \> 30min * st-segment elevation ≥ 0.1 millivolt in 2 or more contiguous leads on the 12-lead ecg or new left bundle branch block (lbbb) * detection of a rise of cardiac biomarker values with at least one value above the 99th percentile upper reference limit (url) * primary coronary artery angiography was planned. exclusion criteria: * emergency thrombolytic therapy was performed before primary coronary artery angiography * cardiogenic shock with no response to hypervolemic treatment or vasopressor * severe cardiomyopathy or valvular disease requiring intervention * coronary ectasia * severe heart failure * contraindication or allergy to antiplatelet drugs * contraindication or allergy to experimental drugs * unable to receive at least 1 year of dual antiplatelet therapy * active bleeding or extreme-risk for major bleeding * severe liver or renal failure * life expectancy \< 1 year * unable or unwilling to provide informed consent * women of child bearing potential * under 18 years of age * hemoglobin \< 90g/l * platelet count \< 100×10\^9/l * can not cooperate (with mental disorders or cognitive disorders)

Keywords: prevention slow flow no reflow nitroprusside tirofiban
effects of traditional moderate intensity training and high intensity interval training in polycystic ovarian syndrome

Conditions: Polycystic Ovarian Syndrome

Summary: to determine the comparative effects of traditional moderate intensity training and high intensity interval training on anxiety, fatigue and quality of life in females with polycystic ovarian syndrome


Eligibility criteria:
inclusion criteria: * participants with bmi greater than 25kg/m2 * oligo- or anovulation/irregular cycles i.e 35 days * married women * primary infertility * a diagnosis of polycystic ovaries based on ultrasound results exclusion criteria: * use of psychiatric or psychotropic medications. * unresolved gynecological conditions i.e cervical dysplasia, pelvic floor prolapse, uterine fibroids, urinary incontinence * diabetes, pregnancy, smoking, illness or injury that prevented or limited exercise performance and existing participation in regular physical activity

Keywords: anxiety fatigue high intensity interval training polycystic ovarian syndrome quality of life.
corteras study: the effect of corticosteroids on early recovery after major surgery in elderly patients

Conditions: Inflammatory Response; Weakness, Muscle

Summary: major surgery induces a systemic inflammatory response, which can influence the post-operative morbidity, such as coagulation disorders and post-operative muscle weakness, hampering early recovery after surgery. single administration of high dose corticosteroids is known to reduce this inflammatory response and could possibly improve the post-operative outcome. the corteras study will evaluate the effect of administration of corticosteroids, as compared to no corticosteroids, on postoperative muscle weakness and quality of recovery after surgery in elderly patients.

the number of elderly patients undergoing surgery is expected to increase in the coming years, due to the increase in life expectancy in the developing world. compared to younger surgical patients, the older patients are at greater risk of mortality and morbidity after surgery. post-operative fatigue is an important complication after surgery. not only is it reported by patients as one of the most distressing symptoms, it is also thought to be a significant contributor to delayed recovery after surgery. from a pathophysiological point of view, muscle weakness could be a major contributor to this post-operative fatigue. recent studies showed a profound reduction in muscle strength after surgery in elderly patients, which lasted for more than 3 months after surgery. this decrease in muscle strength might be induced by an excessive inflammatory response to surgery. glucocorticosteroids are capable of tampering an excessive inflammatory response to surgery and could improve the quality of recovery after surgery. however, a possible effect on post-operative muscle weakness hasn't been specifically investigated. therefore, the main objective of this prospective clinical trial is to evaluate the effect of corticosteroids on early post-operative outcome, focusing on muscle weakness, in elderly patients (≥60 years) undergoing surgery.

Eligibility criteria:
inclusion criteria: * aged 60 years or older. * scheduled for one of the predefined surgical procedures: * off-pump coronary bypass surgery * on-pump coronary bypass surgery * aortic and mitral valve replacement * laparoscopic hemicolectomies * thoracoscopic lung resections * femoral popliteal and tibial bypass surgery and femoral profundoplasty * laparoscopic radical prostatectomies exclusion criteria: * lack of informed consent or inability to give informed consent. * severe postoperative nausea \& vomiting (ponv), needing corticosteroids as ponv prophylaxis. * urgent, not elective surgery * hypersensitivity or known allergic reactions to methylprednisolone * preoperative systemic use of steroids: * including, but not limited to, the use of corticosteroids \> 4 weeks before surgery of at least 4 mg methylprednisolone equivalents. * excluding inhalational and topical steroids * preexisting muscle disease o including, but not limited to: steinert's disease, amyotrophic lateral sclerosis (als), duchenne dystrophy, amputation of dominant arm or hand.
reversal of complete heart block with aminophylline in inferior wall myocardial infarction patients

Conditions: Complete Heart Block; Inferior Wall Myocardial Infarction

Summary: in this study, the investigator will evaluate the rate of reversal of complete heart block with aminophylline in atropine resistant patients with inferior wall myocardial infarction (mi)

administration of aminophylline can result in reversal of complete heart block in a significant number of atropine resistant patients with inferior wall mi. hence, in this study our primary aim is to evaluate the rate of reversal of complete heart block with aminophylline in atropine resistant patients with inferior wall mi.

Eligibility criteria:
inclusion criteria: * adult patients admitted with recent acute inferior wall myocardial infarction (mi) * hemodynamically stable blood pressure * complete heart block with narrow qrs \ 40/min persisting for at least 6 hours, resistant to atropine * temporary pacemaker (tpm) already placed * patient asymptomatic with a mean arterial pressure of greater than 65 mmhg with tpm rate placed at 40/min exclusion criteria: * patients with cardiogenic shock * patients with preexisting permanent pacemaker and implantable cardioverter defibrillator (icd). * patients with a prior history of av block * drugs with dromotropic effects (beta blocker, calcium channel blocker, inotropes) * known liver disease (cirrhosis, hepatitis) * hypothyroidism * unable to consent
the role of placental myeloid cells during gestation, labor and disease

Conditions: Congenital Anomaly of Pregnant Women

Summary: immature myeloid cells (imcs) that are generated in the bone marrow, and differentiate into mature granulocytes, macrophages and dendritic cells (dcs) in the steady state. recently, it was demonstrated that the imc population expands in malignancy, both in animal models and in humans. these cells were described as immunosuppressants but have also been shown to promote tumor angiogenesis. accordingly, imcs were also found to take part in the burn injury wound healing process and other pathologies that involve angiogenesis. it was shown in the investigators' laboratory, that a very similar population of imcs populates the mouse and human placenta, and that these cells actively promote angiogenesis. dendritic cells (dcs) that can differentiate from imcs, are antigen presenting cells (apcs) that initiate and coordinate the innate and adaptive immune responses. dcs can take up a diverse array of antigens and present them to t cells as peptides bound to mhc products. these antigen-specific responses are critical for resistance to infection and tumors. conversely, dcs have roles in autoimmunity, transplant rejection and immunological tolerance. in the reproductive system, dcs were shown to account for 5%-10% of all hematopoietic cells in the uterine decidua at the embryonic implantation site. they were shown to promote angiogenesis during early pregnancy, especially during implantation. very little is known about their function in the placenta and in the latter part of pregnancy when significant angiogenesis takes part. the investigators' preliminary mouse experiments and human data, demonstrate a shift in imc/dc populations with the development of the placenta. the investigators hypothesize that this population shift may contribute to the labor and delivery process. the investigators' aim is to understand the role of these myeloid cell populations during pregnancy, to characterize their phenotype and try to shed light on the cellular and molecular mechanisms of pregnancy complications, such as preeclampsia, pre-term labor, intrauterine growth restriction, etc.

: identification of proangiogenic myeloid cell populations in human placentas. placental myeloid cells from different stages of pregnancy will be analyzed, using flow cytometry. aim 2: characterization of the physiology of myeloid cells identified. cells will be isolated, cultured and tested for proangiogenic properties using matrigel plug assays, endothelial tube formation assays, etc. immune tolerance will be analyzed in vitro using t cell proliferation studies, cytokine production, etc. aim 3: the role of placental myeloid cell populations in pathologies of pregnancy. placentas from human pregnancy pathologies that involve placental dysfunction, such as preeclampsia, pre-term labor, intrauterine growth restriction, will be analyzed using the methods mentioned above

Eligibility criteria:
inclusion criteria: * pregnant women exclusion criteria: * none
a registry study on reduning（a chinese medicine injection）used in hospitals in china

Conditions: Upper Respiratory Tract Infection;; Acute Tracheobronchitis

Summary: this study was advocated by institute of basic research in clinical medicine, china academy of chinese medical sciences in january 2013. the purpose of this study is to make a event monitoring to see whether reduning injection is safe and the characteristic and mechanism of anaphylactic reaction used reduning injection in hospitals in china.

it is very common that chinese medicine injection used in hospitals in mainland china. however safety problems rose in recent years. there could be many uncertain factors influence chinese medicine injection in clinical practice. in order to ensure the safety of public drug use and lower drug-induced risks, a registry study for reduning injection safety surveillance with 3000 patients will be conducted from jan.2013 to mar.2013.at the same time,patients who have anaphylactic reaction are selected as the allergic group and not have anaphylactic reaction are selected as the control group.the proportion of allergic group and control group is 1:4.all the patients who are selected should draw blood. eligibility criteria patients who will use reduning injection in selected hospitals.

Eligibility criteria:
inclusion criteria: * patients using reduning injection from january to march 2013 exclusion criteria: -
the effect of triple p training on children's repetitive behaviors and parents' mood and burnout levels in parents of children with autism

Conditions: Autism Spectrum Disorder

Summary: this project will be conducted in a private autism center in order to investigate the effects of triple p training, which will be given to parents of children with autism spectrum disorder, on the children's repetitive behaviors and the parents' burnout levels. the study is a randomized controlled trial and the study sample will consist of parents of children with autism spectrum disorder. the children/parents included in the study sample will be numbered according to the order of arrival and 35 will be assigned to the intervention group and 35 will be assigned to the control group. during the randomization phase of the study, 70 children/parents with asd will be randomly assigned to the intervention and control groups using statistical analysis software. data analysis will be performed using the statistical package for social sciences (spss v26.0, ibm corp., armonk, ny, usa). descriptive data will be analyzed as mean, frequency and percentage. the conformity of quantitative data to normal distribution will be evaluated using the kolmogorov-smirnov test. paired sample t-test will be used to compare dependent groups with normal distribution, independent sample t-test will be used to compare independent groups with normal distribution. p value will be considered significant if it is less than 0.05.


Eligibility criteria:
inclusion criteria: * having a child diagnosed with autism spectrum disorder between the ages of 0 and 12 * being willing to participate in the study * parents who speak turkish exclusion criteria: * parents of children with autism spectrum disorder who are 13 years of age or older * parents who do not speak turkish

Keywords: autism positive parenting program parent education psychiatric nursing
measuring taste perception during chemotherapy for muscle invasive bladder cancer

Conditions: Bladder Cancer

Summary: alteration in the sense of taste is a frequent symptom that is closely linked to chemotherapy exposure, lowering quality of life and nutritional status. malnutrition is of particular concern in muscle-invasive bladder cancer (mibc), as malnutrition is associated with many negative outcomes from radical cystectomy (the surgical procedure in mibc), which include higher morbidity, poor wound healing, and higher rate of infections after surgery. it is essential to understand taste changes among participants receiving chemotherapy for mibc to create future treatment trials.


Eligibility criteria:
inclusion criteria: * ability of participant or legally authorized representative (lar) to understand this study, and participant or lar willingness to sign a written informed consent. * age ≥ 18 years. * histologically proven mibc (muscle invasive bladder cancer) without metastatic disease diagnosis. * planning to undergo neoadjuvant chemotherapy and radical cystectomy for mibc exclusion criteria: * no prior systemic chemotherapy for mibc. * cannot be simultaneously enrolled in any therapeutic clinical trial, unless receiving standard neoadjuvant chemotherapy on said clinical trial. * any oral or cognitive pathology impairing the ability to perform taste testing procedures. * no other known malignancy within previous 2 years with the following exceptions: low-grade prostate cancer on active surveillance, cll on surveillance / observation, non-melanoma skin cancers. * no psychiatric illness/social situations that would limit compliance with study requirements.

Keywords: musle invasive
a long term safety study to test the combination of aliskiren/ amlodipine / hydrochlorothiazide in participants with essential hypertension

Conditions: Essential Hypertension

Summary: this study tested the safety of the combination of aliskiren/amlodipine/hydrochlorothiazide in participants with essential hypertension.


Eligibility criteria:
inclusion criteria: * outpatients 18 years of age or older * male or female participants are eligible. * mean sitting diastolic blood pressure (msdbp) and mean sitting systolic blood pressure (mssbp) requirements: * for newly diagnosed/untreated participants, msdbp ≥ 100 and \< 120 millimeters of mercury (mmhg), and/or mssbp ≥ 160 and \< 200 mmhg at visit 1 and visit 2. * for previously treated participants, msdbp ≥ 100 and \< 120 mmhg, and/or mssbp ≥ 160 and \< 200 mmhg at visit 2, visit 3, or visit 4. * for participants requiring tapering off their previous antihypertensive medication, they must meet the above criteria and completely discontinue all antihypertensive treatment prior to entering the treatment phase of the study. * participants who are eligible and able to participate in the study, and who consent to do so after the purpose and nature of the investigation has been clearly explained to them (written informed consent). exclusion criteria: * inability to discontinue all prior antihypertensive medications safely for a period of 1 week to 4 weeks as required by the protocol. * participants on three antihypertensive drugs with msdbp ≥ 110 mmhg and/or mssbp ≥ 180 mmhg at visit 1. * participants on four or more antihypertensive drugs at visit 1. * participants with an mssbp ≥ 200 and msdbp ≥ 120 mmhg anytime during the washout period of the study visit 1-4 must be discontinued from the study. * pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive human chorionic gonadotropin (hcg) laboratory test (\>= 5 milli-international units per milliliter miu/ml).

Keywords: essential hypertension high blood pressure
qingre huashi granules combined the modified dual therapy for helicobacter pylori infection

Conditions: Helicobacter Pylori Infection

Summary: this is an open-label, randomized controlled trial. the aim of the study is to evaluate the efficacy and safety of the qingre huashi granules combined the modified dual therapy (or called high dose dual therapy) for helicobacter pylori infection specifically in geriatric patients, compared with the bismuth containing quadruple therapy. a total of 160 eligible patients will be enrolled in 4 hospitals. the eradication rate, symptoms, and the adverse events will be recorded and analyzed.


Eligibility criteria:
inclusion criteria: * current helicobacter pylori infection. * age ≥ 60 years. * diagnosed with syndrome of dampness-heat by traditional chinese medicine. * signed the informed consent document. exclusion criteria: * history of helicobacter pylori treatment. * history of gastric surgery. * allergic to any medications involved in the intervention. * sever complications, such as lung dysfunction, uncontrolled hypertension, diabetes, cardiovascular disease, renal dysfunction (egfr\<60ml/min'1.73m2) , malignant tumor，mental disorder. * taking medications that may be conflict to the intervention drugs. * failing to express symptoms, unwilling to cooperate. * taking any antibiotics within a month.

Keywords: helicobacter pylori geriatic dual therapy bismuth-containing quadruple therapy qingre huashi decoction