Kornimate/medical-research-clean huggingface dataset:
study of a red blood cell deformability parameter in patients with sickle cell disease

Conditions: Sickle Cell Disease

Summary: sickle cell disease is the most common genetic disease in the world. it results in the synthesis of an abnormal hemoglobin (hbs) which, in its deoxygenated form, polymerizes and causes structural changes in red blood cells (rbcs). they become more rigid and less deformable. the fragility of sickle-cell rbcs leads to their massive destruction, leading to chronic anemia (i.e. low hemoglobin in the blood) and to low tissue oxygenation. more rigid and less deformable, sickle-shaped rbcs tend to obstruct microvessels, leading to particularly painful vaso-occlusive crisis (voc), which can cause organ failure (spleen, kidneys, brain, lungs, heart, liver, bone ...) and patient's lifethreatning. a preliminary work on red blood cells of sickle cell patients showed alteration of a parameter measuring the overall deformability of rbcs by assessing the nature of their movement in a shear flow. this parameter is altered sickle cell patients at basal state compared to a population of healthy individuals. this alteration is increased when sickle cell patients are in crisis. the main objective of this project is to study the evolution of this parameter in sickle cell patients according to their health status (basal state vs vaso-occlusive crisis). the investigators hypothesize that the alteration of the rbc deformability parameter is significant before symptoms of vaso-occlusive crisis (several hours to several days). the main objective is a weekly analysis of the evolution of the parameter in 30 sickle cell patients (ss or sb°) in the basal state and daily in at least 6 patients at the beginning, during and just after a vaso-occlusive crisis. the comparison between the parameter measured in a subject in the basal state and in the same subject in crisis will be performed. the criteria for the presence of a vaso-occlusive crisis were: the appearance of a attacks of pain affecting at least two territories +/- fever\> 38.3 +/- dyspnea and / or sputum. the investigators will differentiate the moderate voc managed at home with low-level analgesics and voc requiring hospitalization. the number of days of hospitalization, the occurrence of thrombotic complications, the degree of anemia and hemolysis will be noted. the measurement of the parameter will be performed on a capillary sampling of 40 microliters performed at the fingertip, weekly outside crises and daily when a crisis occurs.


Eligibility criteria:
inclusion criteria: * homozygous ss or sb° sickle cell patients * person without regular blood transfusion exclusion criteria: * other general diseases * psychiatric disorder * alcoholics * minors * absence of informed consent * pregnant or lactating woman * person under guardianship * person living in a health or social institution * person in emergency * person out of healthcare system * person deprived of liberty * person who has received a blood transfusion in the previous 3 months * person with regular blood transfusion or in a blood transfusion program
genetic and nutritional causes of heart birth defects

Conditions: Heart Defects, Congenital

Summary: each year in the united states, thousands of babies are born with heart defects. women who take folic acid during pregnancy have a lower risk of giving birth to infants with heart defects, but the reason for this remains unknown. this study will examine the relationship between genes, nutrition, and the occurrence of heart defects in infants.

congenital heart defects are the most common type of birth defect; each year, more than 30,000 babies in the united states are born with this kind of abnormality. conotruncal heart defects, considered to be a very serious type of defect, involve a structural abnormality in the chambers of the heart or blood vessels that lead to and from the heart. infants born with conotruncal defects must undergo complex open heart surgery, and there is a high fatality rate. folic acid supplementation during pregnancy has been shown to reduce the risk of conotruncal defects. however, some women who take folic acid during pregnancy still give birth to infants with conotruncal defects. specific genes may influence the way individuals metabolize folic acid, and variations in these genes may make some infants more prone to developing heart defects. this study will examine the relationship between genes, maternal nutritional intake, and conotruncal heart defects. the results from this study may help to determine genetic and nutritional causes of congenital heart defects. this study will use previously collected data on 550 infants born with conotruncal defects and 1060 infants born without heart defects. there will be no study visits specifically for this study. infant dna will be analyzed for genes that may play a role in folate metabolic pathways. blood previously collected from the mothers during pregnancy will be analyzed for differences in nutrient intake. specifically, levels of folic acid, choline, vitamin b12, and methionine will be examined.

Eligibility criteria:
inclusion criteria: * conotruncal heart defect exclusion criteria: * if part of control group, must not have heart defect

Keywords: congenital heart defects
effect of caffeine on preterm infants' bone mineral content

Conditions: Osteopenia (Disorder); Apnea of Prematurity

Summary: the primary objective was to determine whether caffeine therapy is associated with decreases bone mineral content using dual energy x-ray absorptiometry. secondary objectives were to determine whether caffeine therapy is associated with increased incidence of nephrocalcinosis or bone fracture.


Eligibility criteria:
inclusion criteria: preterm infants with gestational age of 34 weeks or less consecutively admitted to the neonatal intensive care unit exclusion criteria: renal or endocrinal diseases congenital anomalies suspected chromosomal aberrations receiving diuretics or steroid therapy

Keywords: caffeine bone mineral content
study of the level of a protein which could predict the development of a fungal infection in patients with acute leukemia

Conditions: Acute Leukemia; Invasive Fungal Infection

Summary: the aim of this study is to investigate levels of a protein, mannose binding lectin, in patients with acute leukemia who develop or not an invasive fungal infection.


Eligibility criteria:
inclusion criteria : * persons who have provided written consent * patients with national health insurance cover * patients with malignant hemopathy who have been treated with chemotherapy able to induce profound neutropenia (pn \< 500 / mm3) lasting more than 10 days. * patients with malignant hemopathy who have received an autologous bone marrow graft * patients with severe idiopathic medullar aplasia (pn \< 500 / mm3) who need to be hospitalized for at least 10 consecutive days (with or without treatment with immunosuppressants) exclusion criteria: * patients who have received an bone marrow psc allograft (as such patients have a risk of aspergillosis, which appears in most cases after medullar recovery; they will not be included in the study). * patients who have received an autologous psc graf (as the duration of neutropenia is in most cases less than 10 days). * patients whose neutropenia, retrospectively assessed, lasted less than 10 days.
comparison study of oxytocin versus tranexamic acid and etamsylaye versus placebo(saline)

Conditions: Blood Loss, Surgical; Blood Loss, Postoperative

Summary: comparison study between oxytocin versus tranexamic acid and ethamsylate versus normal saline as pre-operative administration.

comparison study between oxytocin versus tranexamic acid and ethamsylate versus normal saline to reduce intra operative bleeding and postoperative bleeding during elective cesarean delivery.

Eligibility criteria:
inclusion criteria: * pregnant females admitted for elective cesarean section. * gestational age of pregnancy (38 weeks to 40 weeks). * the average height of 145 to 160 cm,average body weight of 45 to 85 kgs. * singleton living fetus. * no medical disorders. * informed oral consent from the patient. exclusion criteria: * severe medical and surgical disorders as thyroid dysfunction, which was excluded by routine thyroid function test (free t3, free t4, and thyroid stimulating hormone(tsh), all of them should be within normal limits). * bleeding tendency, for example, disseminated intravascular coagulopathy, which was excluded by platelet count, coagulation time, bleeding time, prothrombin time, partial thromboplastin time, and thrombin time (all should be within normal). * acute liver or kidney diseases; blood disorders, such as anaemia. * allergy to tranexamic acid. * risk factors for pph, such as polyhydramnios, fetal macrosomia, antepartum haemorrhage. * ante partum hemorrhage such placental abruption.

Keywords: blood loss cesarean section oxytocin tranexamic acid etamsylate saline intra-operative postoperative
simulation-informed modelling and personalized evaluation (simple) in ageing populations

Conditions: Neurodegenerative Diseases; Aging; Brain; Cognitive Dysfunction

Summary: multimodal magnetic resonance imaging (mri), detecting brain structural and functional changes, has emerged as a powerful and promising technique to study individual's brain, as t1-weighted scans can detect morphometric features, diffusion tensor imaging (dti) scans can quantify structural connectivity, and functional mri can capture the features of functional connectivity. notably, with the advances in quantitative methods, computational models of brain age and brain-predicted age difference (brain-pad) detecting the ageing effects on individual's brain features are becoming increasingly popular in clinical studies, which might revolutionize the diagnostic and prognostic phonotypes of age-related brain diseases globally.

the score of brain-pad has threefold explanations: a. negative score representing decelerated brain ageing (brain age\ chronological age); c. score equal to zero, representing normal brain ageing (brain age=chronological age). the score of brain-pad indicates the brain ageing pattern with the interaction of lifestyle and cognitive status at individual level. for example, based on structural mri scans, a younger brain age or a negative score of brain-pad was found to be associated with better cognition, which indicates the potential utilities of brain age matrices in predicting individual's cognitive maintenance and healthy longevity

Eligibility criteria:
inclusion criteria: * chinese old adults are the ones who are over 60 years of chronological age. * sleep disturbance: individual's subjective sleep quality is assessed using the pittsburgh sleep quality index (psqi) with a total score \>5. exclusion criteria: * history of bipolar disorders or psychosis. * history of major neurological deﬁcits, including stroke, transient ischemic attack or brain tumor. * unable to participant magnetic resonance imaging (mri) scanning.

Keywords: mri brain age deep learning healthy longevity resilence cognitive maintenance simulation imaging phenotypes
treatment of acute acl injuries in young patients using a rebound acl brace

Conditions: Anterior Cruciate Ligament Injuries; Anterior Cruciate Ligament Rupture; Anterior Cruciate Ligament Tear

Summary: this study evaluates the use of a brace in acute anterior cruciate ligament (acl) injuries in children and adolescents. half of the participants will receive a so called rebound acl brace together with a standardized rehab program supervised by a physiotherapist, while the other half will receive only the standardized rehab program supervised by a physiotherapist

a well known treatment of posterior cruciate ligament injuries in the acute phase is a brace which pushes the tibia anteriorly, and the result of the treatment is often successful with healing of the ligament. similarly, in anterior cruciate ligament injuries, it is suggested that a rebound acl brace which pushes the tibia posteriorly can facilitate healing of the acl. it does not have as successful treatment results as the pcl brace, but the type and location of the acl injury has in previous studies not been well defined. we will, after having described the localisation and type of acl injury treat the intervention group with the rebound acl brace and a standardized rehab program and the control group with standardized rehab program alone. the randomization is made blockwise of 4, to treatment a= brace+physiotherapy or b=physioterapy. the groups are stratified for gender and age (\ 14 years)

Eligibility criteria:
inclusion criteria: * no previous significant knee injury * trauma followed by hemarthrosis and clinical suspicion of an acute acl injury * acute acl rupture seen on mri exclusion criteria: * previous ipsilateral knee surgery * associated injuries which require early surgical intervention

Keywords: acl children and adolescents rebound acl brace
long-term follow-up (ltfu) for gene therapy of leukocyte adhesion deficiency-i (lad-i)

Conditions: Leukocyte Adhesion Deficiency

Summary: this long-term follow-up (ltfu) for gene therapy of leukocyte adhesion deficiency-i (lad-i) is a continuation of a phase 1/2 clinical study to evaluate the safety and efficacy of the infusion of autologous hematopoietic stem cells transduced with a lentiviral vector encoding the itgb2 gene

following the end of participation in study rp-l201-0318, patients will be offered enrollment into this ltfu protocol. patients will be followed for up to 15 years following the rp-l201 infusion in the parent study, until the patient dies, withdraws consent, or is lost to follow-up (whichever occurs first). for all follow-up visits, remote evaluation facilitated by local health care providers (with blood sample shipment to relevant laboratory facilities) is permitted; however, annual visits to the study center are required during initial 3 years post- rp-l201 infusion. visits where a bone marrow sample is being collected are required to be performed at the study center for the duration of the study. peripheral blood samples and bone marrow samples will be archived and tested when clinically or scientifically indicated, as in the event of development of a second malignancy.

Eligibility criteria:
inclusion criteria: 1. enrolled in the phase i/ii study rp-l201-0318. 2. received an autologous infusion of cd34+ hematopoietic stem cells modified with a lentiviral vector containing the itgb2 gene, encoding for the human cd18 receptor in the parent study rp-l201-0318. 3. able to adhere to the study visit schedule and other protocol requirements. 4. provided written informed consent and, as applicable, assent to participate in the current study. exclusion criteria: there are no criteria for exclusion in this study.

Keywords: lad-i lad
therapeutic imaging biomarkers for amyotrophic lateral sclerosis

Conditions: Amyotrophic Lateral Sclerosis

Summary: study the cervical spinal cord and brain over time to assess changes and differences in subjects with amyotrophic lateral sclerosis.

investigators will study cervical spinal cord chemical concentrations and cervical spinal cord and brain microstructure in amyotrophic lateral sclerosis(als) patients who have had a stem cell transplant compared to als patients who have not had a stem cell transplant. investigators intend to determine cervical spinal cord chemical concentrations and cervical spinal cord and brain microstructure in amyotrophic lateral sclerosis(als) patients who have had a stem cell transplant and compare these to corresponding measures in amyotrophic lateral sclerosis(als) patients who have not had a stem cell transplant.

Eligibility criteria:
inclusion criteria: 1. 18 years of age or older 2. subjects with amyotrophic lateral sclerosis - exclusion criteria: 1. do not have opportunistic central nervous system infection 2. do not have a history of head injury 3. do not have cerebrovascular disease 4. do not have a contraindication for mri(e.g. cardiac pacemaker, ferromagnetic or metallic implants). 5. must not be pregnant -
attention bias modification treatment for children with social anxiety

Conditions: Social Phobia

Summary: children with social anxiety will be randomly assigned to either attention bias modification treatment (abmt) designed to direct attention away from threat or a placebo control condition not designed to change attention patterns. outcome measures will be depression and social anxiety symptoms as measured by gold standard questionnaires as well as diagnosis of social phobia disorder and symptom counts derived from structured clinical interviews with children and their parents. we expect to see significant reduction in social anxiety symptoms in the attention bias modification treatment (abmt) group relative to the placebo control group.


Eligibility criteria:
inclusion criteria: * children suffering from social anxiety exclusion criteria: * pharmacological or psychological treatment

Keywords: attention bias modification treatment cognitive bias modification attention training social anxiety
fresh start experiment

Conditions: Diabetes; Hypertension

Summary: the investigators are proposing an experiment to help humana investigate when to launch programs or send messages that are designed to improve customers' engagement. the investigators' past research has shown that certain life events and calendar events (e.g., a job change, a birthday, a holiday, monday) feel like a "fresh start" to people and have the potential to motivate them to begin pursuing their health goals (e.g., exercising, starting a diet, quitting smoking).

the investigators are proposing an experiment to help humana investigate when to launch programs or send messages that are designed to improve customers' engagement. the investigators' past research has shown that certain life events and calendar events (e.g., a job change, a birthday, a holiday, monday) feel like a "fresh start" to people and have the potential to motivate them to begin pursuing their health goals (e.g., exercising, starting a diet, quitting smoking). in this experiment, the investigators will test (a) whether humana can increase the effectiveness of its messages by sending them to customers around fresh starts moments and (b) whether highlighting a recent fresh start event in humana's messages can further increase customer engagement.

Eligibility criteria:
inclusion criteria: * customers of our insurance company partner exclusion criteria: * none
serum creatinine change / renal adverse effect with use of non-steroidal painkillers in axial spondyloarthritis patients

Conditions: Axial Spondyloarthritis

Summary: 2 non-steroidal anti-inflammatory drugs (nsaids), indomethacin and etoricoxib were prescribed sequentially in axial spondyloarthritis patients according to the internationally accepted guidelines to determine serum creatinine change with nsaids use.

the study had 2 phases. in phase 1, patients of axial spondyloarthritis were randomized into 2 groups; group a and group b. they were put on indomethacin 150 mg/day and indomethacin 100 mg/day respectively and were followed up at 3rd week. those who had normal serum creatinine and responded with the drug were followed up to 24th week. those who did not respond were excluded from phase 1 and were enrolled in phase 2. non-responders of indomethacin 150mg and indomethacin 100 mg were put on etoricoxib 90 mg and etoricoxib 60 mg respectively. again followed up to 24th week.

Eligibility criteria:
inclusion criteria: * spa (axial) patients according to assessment of spondyloarthritis international society (asas) criteria with basdai \> 4 exclusion criteria: * inadequate response to therapeutic dose of indomethacin or etoricoxib, taken for at least 2 weeks continuously * abnormal serum creatinine : serum creatinine \>1.3 mg/dl * abnormal sgpt: sgpt \> 40 u/l * hypertension: systolic blood pressure \> 140 mm hg and/ or diastolic blood pressure \>90 mm hg or on anti-hypertensive drug * dyspepsia or active peptic ulcer disease : upper abdominal discomfort or upper abdominal pain related with food or peptic ulcer disease diagnosed by upper gastrointestinal endoscopy * diabetes mellitus: abnormal random plasma glucose or diagnosed case of diabetes mellitus * ischemic heart disease: history of angina or ecg changes suggestive of ischemic heart disease * active congestive heart failure: pedal edema with tender hepatomegaly with raised jvp or diastolic dysfunction on echocardiography * asthma: diagnosed case of asthma or rhonchi on chest auscultation * bleeding problems: having a history of prolonged bleeding * pregnancy: missed period followed by positive pregnancy test * simultaneous use with certain medications such as warfarin, phenytoin, cyclosporine, probenecid, lithium, digoxin, ace inhibitor, thiazide
postoperative pain of robotic, endoscopic and open lateral neck dissection

Conditions: Pain, Postoperative; Thyroid Diseases; Surgery

Summary: postoperative pain is a good indicator to confirm the advantages of the surgical methods in the era of minimally invasive surgery. lateral neck dissection requires extensive dissection which may leads to postoperative numbness and pain. robotic thyroid surgery has the advantage of precise and careful dissection and avoid the l-shape incision in the open approach. the study aims to explore the pain intensity and severity of lateral neck dissection on operation day, postoperative month 1 and postoperative month 3 among the robotic, endoscopic and open approach.


Eligibility criteria:
inclusion criteria: * patients underwent lateral neck dissection via robotic, endoscopic or open approach * clinical diagnosis of differentiated thyroid cancer * clinical diagnosis of metastatic lateral lymph nodes exclusion criteria: * participants with distant metastasis * participants with history of neck surgery or radiation * participants with vocal fold fixation by preoperative fibrolaryngoscope

Keywords: lateral neck dissection robotic thyroid surgery minimally invasive surgery
iv papaverine prior to propess for labor induction

Conditions: Induced Vaginal Delivery

Summary: we aim to evaluate the effect of administering papaverine prior to pge2 (propess) insertion on changes in bishop-scores and on the induction-to-delivery interval.

more than 22% of all pregnant women undergo induction of labor. induction of labor is usually medically indicated for maternal and fetal related conditions; however, elective induction has become more common since the arrive trial. women with an unfavourable cervix, according to bishop-score (\<6), are prone to higher induction failure rates and are candidates for cervical ripening. the cervix is composed of connective tissue and smooth-muscle located mainly beneath the internal os. papaverine is an antispasmodic-musculotropic drug that targets smooth-muscle, resulting in decreased muscle spasm and subsequent smooth-muscle relaxation. the half-life of the drug is in the range of 0.5-2 hours, and its action starts 10 minutes after administration. short-term use of papaverine during the first trimester has been reported as safe. however, outcome data are lacking of the use of mucosotropic-agents prior to pge2 (propess) insertion. we will investigate this in a trial in which the co-primary outcomes were the change in bishop-score after pge2 extraction and the pge2 insertion-to-delivery interval

Eligibility criteria:
inclusion criteria: * singleton term pregnancy * bishop score * need for labor induction with pge2 * vertex presentation * viable fetus exclusion criteria: * prelabour rupture of membrane * twins pregnancy * previous cesarean section * allergy to the study medication * fetal anomaly contraindications for vaginal delivery * maternal supraventricular tachicardia

Keywords: labor induction papaverine propess bishop score induction to delivery interval