Kornimate/medical-research-clean huggingface dataset:
osteoarthritis running & cartilage assessment

Conditions: Osteoarthritis, Knee

Summary: knee osteoarthritis (oa) is a debilitating disease affecting millions of canadians. exercise is a core treatment for knee oa, and is advocated by all clinical guidelines. however, the safety of recreational running in the presence of knee oa is unclear. there are no studies available to provide direct data to appropriately inform runners and clinicians whether running should be advocated for joint health. our research study will address this gap.


Eligibility criteria:
inclusion criteria: all: * aged greater than 40 years * recreational runners who run at least twice per week for a total of at least 10 km, and have done so for a minimum of 12 months * comfortable running on a treadmill for 30 minutes. tfoa group: * exhibit radiographic evidence of mild or moderate tibiofemoral osteoarthritis (tfoa) according to the kellgren and lawrence oa classification scale (grade ≥ 2) * report knee pain on most days of the previous 3 months (during running and activities of daily living). control group: * free of any radiographic signs of tfoa according to the kellgren and lawrence scale (grade = 0) * pain free in both knees for the 12 months prior to recruitment. exclusion criteria: all: * any history of traumatic knee injury (fracture, severe sprain, meniscus injury) * presence of an inflammatory arthritic condition * presence of any health condition (other than oa in the tfoa group) affecting normal movement or precludes engaging in moderate to high impact activities such as running * use of any oral or injected corticosteroids or viscosupplementation in the previous 6 months * any history of surgery in either knee * standard contra-indications to magnetic resonance imaging (mri).

Keywords: osteoarthritis knee running magnetic resonance imaging mri
a study of thalidomide in the treatment of refractory uremic pruritus

Conditions: Haemodialysis; Uremic Pruritus; Thalidomide

Summary: the purpose of this study is to evaluate the safety and efficacy of thalidomide in the treatment of refractory uremic pruritus in maintenance hemodialysis patients.

a prospective, randomized, double-blind, placebo-controlled study was conducted to explore the efficacy and safety of thalidomide in the treatment of refractory urmia pruritus.

Eligibility criteria:
inclusion criteria: * maintenance hemodialysis patients (≥3 month), 3 times/week, 4 hours/session * spkt/v≥1.2 * the diagnosis was refractory urmia pruritus and pruritus score ≥8 score * patients with sleep disorders need to stop sleeping pills * be able to complete the form by yourself or with the help of others * informed consent exclusion criteria: * participants in other clinical trials within 1 month * people with thalidomide allergy * accompanied by severe calcium and phosphorus metabolism disorder (serum calcium≥3.0mmol/l or serum phosphorus≥2.8mmol/l or serum ipth≥800pg/ml) * patients with other medical conditions that cause itchy skin * with severe systemic infection, severe anemia and other serious complications * patients with peripheral neuropathy * other serious systemic diseases include systemic lupus erythematosus, multiple myeloma, thrombotic microangiopathy, and extensive metastasis of malignant tumors * patients with a history of thromboembolism were excluded from picc-induced thrombosis * pregnant woman
the effects of exercise on gait characteristics, balance, and performance in patients with normal pressure hydrocephalus

Conditions: NPH (Normal Pressure Hydrocephalus)

Summary: the goal of this study is to investigate effect of exercise program on balance, gait and performance in patients with normal pressure hydrocephalus applied with lumbar puncture. the main question it aims to answer are: * home based exercise program effective on balance, gait and performance * telerehabilitation exercise program effective on balance, gait and performance researchers will compare home based exercise group, telerehabilitation group and control group to see if difference in terms of balance, gait and performance


Eligibility criteria:
inclusion criteria: * age 60-90 years old * fulfilling the following clinical criteria for inph, as proposed by the relkin and colleagues * able to walk independently (without physical assistance from a person and/or a device) exclusion criteria: * patients who had severe physical disability or immobility, major primary psychiatric disorders (eg, schizophrenia, bipolar disorder), unstable major medical illnesses (eg, acute coronary syndrome, respiratory failure), acute cerebrovascular disease, severe visual or hearing impairments were excluded. * patients with diagnosis of seconder normal pressure hydrocephalus were also excluded.

Keywords: balance gait performance
allogenic mesenchymal stem cell intraarticular injection for knee osteoarthritis therapy

Conditions: Knee Osteoarthritis

Summary: this phase i and ii double blinded randomized clinical controlled trial investigates the safety and efficacy of intraarticular knee injection with allogenic adipose derived mesenchymal stem cells (ad-msc), in patients suffering from mild-moderate knee osteoarthritis compared to placebo injection with saline.


Eligibility criteria:
inclusion criteria: * chronic knee pain (defined for at least 6 months with nrs 4 or above when pain worst) * patients with grade ii-iii osteoarthritis according to the kellgren lawrence classification and a joint width space of 1-3 mm. * axial hip, knee, ankle x-ray with no more than 5 degrees valgus/varus deformity * medial, lateral or dual compartment oa as determined above * bmi \<35 * danish speaker * patients must be legally competent and must be able to sign the written consent exclusion criteria: * severe osteoarthritis (grade iv according to kellgren lavrence classification) * intraarticular tumor, infection or fracture * pregnancy and breast feeding * cognitive impairment * treatment with cytostatic drugs * previous intraarticular knee injection in the past 3 mo. * unable to perform mri scan (non-compatible implants, claustrophobia and severe obesity(\>bmi 35) * previous ligament reconstruction * meniscal operation with resection with more than 50% or multiple meniscal operations (more than one resection) * diabetes mellitus type 1 and 2 * knee instability on physical examination * history of allergy to antibiotics * concomitant severe infection, malignant tumor, coagulation diseases or uncontrolled or unmanaged systemic disease * presence of other types of inflammatory arthritis

Keywords: allogenic adipose derived mesenchymal stem cells adipose derived mesenchymal stem cells mesenchymal stem cells stem cells
prevalence and dynamic of sleep-disordered breathing in patients pre and post heart transplantation

Conditions: Sleep Disordered Breathing Central; Heart Failure; Heart Transplantation

Summary: sleep-disordered breathing is believed to appear at a high prevalence in end-stage heart failure patients and the presence of sleep-disordered breathing has been associated with increased mortality. this study is designed to investigate prevalence and dynamics of sleep-disordered breathing in end-stage heart failure patients pre and post heart transplantation.

sleep-disordered breathing is believed to appear at a high prevalence in end-stage heart failure patients and the presence of sleep-disordered breathing has been associated with increased mortality. this study is designed to investigate prevalence and dynamics of sleep-disordered breathing in end-stage heart failure patients pre and post heart transplantation, as this topic is hardly studied yet and previous reports suggest changes in the entity of sleep-disordered breathing through heart transplantation. the circumstances and the impact of sleep-disordered breathing or residuals in heart transplant patients is not well understood yet and will be subject of this study.

Eligibility criteria:
inclusion criteria: * end-stage heart failure patients assigned and eligible for heart transplantation exclusion criteria: * heart failure patients not eligible for heart transplantation

Keywords: sleep-disordered breathing heart failure heart transplantation
efficacy of wb-ems in frail older people

Conditions: Frailty Syndrome

Summary: exercise in general and resistance training (rt) in particular have demonstrated positive effects on frailty outcomes, including physical functioning. however, frail older people with functional impairments are among the least physically active and have problems reaching high-intensity levels. whole-body electromyostimulation (wb-ems) allows the simultaneous innervation of all large muscle groups by external electrical stimulation, inducing a high-intensity rt at a low subjective effort level. the efficacy of wb-ems in frail older people has yet to be determined. the primary objective of this study is to investigate the efficacy of wb-ems in frail older people.


Eligibility criteria:
inclusion criteria: * aged 65 years and older * frail according to tilburg frailty indicator * residing in assisted living facility or nursing home * able to walk 4m w/o walking aid but without personal assistance * no prior wb-ems exposure exclusion criteria: * severe visual or hearing impairments * major cognitive impairment (mmse \<10) * medications with muscle-anabolic effects * medical conditions affecting trainability of muscles (e.g. myasthenia gravis, cushing syndrome, morbus mcardle) * surgery within past two months * history of rhabdomyolysis * medical conditions affecting sensation of electrical stimuli (e.g. severe polyneuropathy) * severe renal insufficiency (egfr\<30 ml/min/1.73m²) * electronic implants * acute or untreated abdominal wall or inguinal hernia * ventricular arrhythmias requiring therapy
massage to improve uterine artery blood flow

Conditions: Pregnancy; Depression

Summary: this project will investigate the effects of massage therapy on depressed pregnant women. the investigators expect that massage therapy will improve blood flow from the mother to the fetus and reduce prematurity and depression.

prenatal depression has been associated with adverse neonatal outcomes including preterm birth and low birthweight. potential underlying mechanisms for prenatal depression effects on prematurity and low birthweight involve the elevated sympathetic nervous system sns and hypothalamic pituitary adrenal hpa axis function noted in depressed pregnant women. these may lead to increased uterine artery resistance and the resulting limited blood flow, oxygen and nutrients to the fetus. moderate pressure massage therapy may reduce this problem in depressed pregnant women by decreasing sns and hpa axis function, resulting in decreased uterine artery resistance, increased oxygen and nutrients to the fetus and lower prematurity and low birthweight. an alternative model being explored here is that moderate pressure massage may increase progesterone/estriol ratios, which counteract the negative cortisol effects on gestational age. eighty pregnant women with depression symptoms will be recruited at approximately 20 weeks gestation and randomly assigned to a moderate pressure massage therapy or to a sham light pressure massage touch/attention control group. the women will receive 20-minute weekly massage therapy sessions from 20 to 30 weeks gestation. at 20 and 30 weeks gestation, depressed symptoms will be assessed using the ces-d, and saliva samples will be collected to assay alpha amylase as an sns marker, cortisol as an hpa axis marker and progesterone and estriol levels. maternal doppler ultrasound will be conducted to assess the uterine artery resistance index as an estimate of uterine artery blood flow. upon delivery, the mothers' medical charts will be reviewed to record gestational age and birthweight. the investigators are hypothesizing that the moderate pressure massage group will elicit an increase in progesterone/estriol ratios and decreases in alpha amylase and cortisol levels, which in turn will lead to reduced uterine artery resistance and a lower incidence of prematurity and low birthweight.

Eligibility criteria:
inclusion criteria: * uncomplicated singleton pregnancy * depression * \< 20 weeks ga at recruitment exclusion criteria: * pregnancy complications * hiv * smoking, drug use

Keywords: pregnancy depression massage
influence of wrap fixation technique on the results of fundoplication

Conditions: Gastro Oesophageal Reflux Disease

Summary: patients who underwent anti-reflux surgery were divided into two groups. in the i group nissen fundoplication was supplemented with suturing wrap to the crura or the body of stomach using two non-absorbable stitches on each side. control group included patients who underwent classic nissen fundoplication without wrap fixation. all patients were assessed before and after surgery using validated symptoms and quality of life (gerd-hrql) questionnaires, 24-h impedance-ph monitoring and barium-swallow.


Eligibility criteria:
inclusion criteria: * age: 20 - 80 years; * gastroesophageal reflux disease as evidence by gastroscopy and ph-monitoring; * hh type i, ii exclusion criteria: * age \ 80 years; * unable to undergo laparoscopic fundoplication due to: severe comorbidities (asa iii and more), previous major surgery with severe adhesions, etc.; * hh type iii, iv; * bmi \ 45 kg/m²; * pregnancy (in females); * oesophageal motility disorders; * oesophageal peptic strictures; * oesophageal diverticula, other types (i.e. non-reflux) of chronic esophagitis, connective tissue disorders (e.g. scleroderma); * history of oesophageal/gastric/duodenal surgery including vagotomy; * relapsing course of ulcer disease/hyperacid gastritis including complicated by delayed gastric/duodenal emptying

Keywords: gastro oesophageal reflux disease, nissen fundoplication
comparing the effects of upper and lower body aerobic exercise on pain in individuals with chronic knee pain

Conditions: Chronic Knee Pain

Summary: the investigators want to compare the effects of upper versus lower body moderate aerobic exercise on the experience of pain in individuals with chronic knee pain. participants will attend the laboratory on 4 separate occasions to complete a series of exercise tests and experimental pain tests.

pain has a multifaceted nature encompassing peripheral drivers (i.e. loading), peripheral and central nervous systems (peripheral and central sensitisation) and cognition (i.e. fear). most recently, evidence supports that chronic pain in oa may cause alterations to the peripheral and central nervous systems. despite this, current research has mainly targeted peripheral drivers (usually weight reduction) and cognition (educational programmes) with results highlighting that such methods are not always effective in reducing pain. it would be useful to provide a wider range of choice when prescribing exercise for oa for those which the current prescription is ineffective or un-desirable. acutely, both localised and generalised exercise involving the knee joint in individuals with koa is known to increase symptomatic pain in some. however, research suggests that diverting exercise away from the affected joint may improve pain perception and pain experience in a subset of individuals by targeting cognition (attention away from the joint) and alleviating peripheral drivers of pain (reduced loading) while still presenting systemic physiological benefits that come with acute aerobic exercise which target peripheral and central sensitisation. currently, there is only one study (burrows et al, 2014) which has compared the effects of acute upper vs. lower body exercise on pain perception in koa patients and this was employing resistance exercise. although this study found positive effects of upper body exercise on pain, this pain was experimentally induced, and symptomatic pain was not measured. the investigators aim is to determine the effects of a single bout of upper body aerobic exercise on experimentally induced and symptomatic pain in individuals with chronic knee pain in comparison with lower body aerobic exercise.

Eligibility criteria:
inclusion criteria: * aged ≥45 years * male or female * knee pain for ≥3 months * activity related joint pain * no joint related morning stiffness, or morning stiffness lasting less than 30 minutes. exclusion criteria: * specific joint injury within the last 6 months * inability to undertake cycling exercise * use of anti-inflammatory medication * smoker (or having quit \<6 months ago) * osteoarthritis at any upper body sites that would affect ability to complete arm-cycling exercise.
expanding live donor kidney transplantation through advocacy training and social media

Conditions: Kidney Failure; Kidney Diseases

Summary: this pilot study will be a clinical trial to test the feasibility and effectiveness of an educational intervention and a mobile health intervention in adults with end stage renal disease (esrd) who have not yet identified a potential live donor.

transplant candidates are hesitant to discuss their illness and the difficulties associated with dialysis, and are therefore reluctant to pursue live donor kidney transplant (ldkt). the investigators will conduct a prospective 3-arm randomized controlled trial with two novel interventions to increase live donation. arm 1 includes ldc program and the facebook app, arm 2 includes just the facebook app, and arm 3 includes standard of care. the investigators primary objective is to demonstrate the the effectiveness of these interventions in increasing live donor transplantation rates for candidates with no prior potential live donor.

Eligibility criteria:
inclusion criteria: * kidney transplant candidates aged≥18 added to the waitlist in the last year with no potential live donors are eligible. * if there is an individual willing to donate, but the candidate is unwilling to consider this option or this particular individual, the candidate is eligible for the trial and may still benefit from identification of new donors or increased comfort accepting donation from others. * participants at johns hopkins university or university of alabama must speak english. participants at northwestern university must speak english or spanish. exclusion criteria: * candidates with live donors currently under evaluation for donation will be excluded. * those with a previous kidney transplant will be excluded

Keywords: live donor transplant, social media, education, advocacy, live donor
alternate day buprenorphine administration, phase xi - 16

Conditions: Opioid-Related Disorders

Summary: the purpose of this study is to evaluate open buprenorphine dosing with dose choice after open exposure.


Eligibility criteria:
please contact site for information.
adjuvant radiotherapy after cystectomy for muscle invasive bladder cancer

Conditions: Toxicity

Summary: a radical cystectomy + extended pelvic lymph node dissection is considered to be the treatment of choice for patients with muscle invasive bladder cancer (mibc). despite this aggressive treatment the outcome is poor and ultimately, 30% of the patients with ≥pt3 tumors develop a pelvic recurrence. one- and 2-years survival for patients developing a local recurrence after cystectomy is only 8% and 3% respectively, with a median survival of \<4 months. for patients with lymph node recurrence prognosis is somewhat better, but nevertheless still disappointing with reported 1- and 2 years survival of 42% and 11% respectively. the investigators hypothesize that an earlier implementation of external beam radiotherapy (ebrt) i.e. in the adjuvant setting, will prevent local and lymph node recurrence and improve disease free- and overall survival as local recurrence is linked to the development of distant metastasis. adjuvant ebrt was tested in a prospective randomized trial and resulted in a 20% increase in 5-year disease free survival. despite those impressive results, severe intestinal toxicity rates hampered the enthusiasm to use adjuvant ebrt, till now. in the last decade, great technological advancements in ebrt planning, such as intensity modulated arc therapy (imat), and positioning have been realised. this has resulted in a better coverage of the target volume while sparing normal tissue (mainly small bowel) and in a more precise delivery of the ebrt. therefore, it is desirable to reconsider the use of adjuvant ebrt in selected mibc patients.

the investigators plan to perform a prospective phase 2 study including 76 patients. radiation up to a median dose of 50 gy in 25 fractions will be delivered with imat to the pelvic lymph node regions. if there is a positive surgical margin, the operative bladder bed will be included in the radiation field. a simultaneous integrated boost to 64 gy to the positive lymph nodes will be delivered. pathological evaluation on cystectomy specimen includes: tumor stage and grade, area of necrosis (absolute and relative), micro vessel density, epidermal growth factor receptor.

Eligibility criteria:
inclusion criteria: muscle invasive bladder cancer with: * ≥ pathological tumor stage (p)t3 stage + presence of lymphovascular invasion on pathological examination * pt4 * \<10 lymph nodes removed * positive lymph nodes * positive surgical margins exclusion criteria: -

Keywords: assessment of qol (eortc qlq-c30)
evaluation of clinical and microbial efficacy and safety of azasite compared to vehicle for bacterial conjunctivitis (c-01-401-003)

Conditions: Bacterial Conjunctivitis

Summary: the purpose of this study is to evaluate the clinical and microbial efficacy and safety of azasite compared to vehicle for bacterial conjunctivitis. adults and children one year of age and older with bacterial conjunctivitis in at least one eye may be eligible. subjects will be randomly assigned to receive either 1.0 % azasite or vehicle. three visits will be required for this study.


Eligibility criteria:
inclusion criteria: * male or female subject, of any race, who is at least 1 year of age. * subjects must have a clinical diagnosis of acute bacterial conjunctivitis and exhibit mucopurulent or purulent conjunctival discharge (crusty or sticky eyelids, globular and yellow discharge) and redness in at least one eye. * the symptoms of bacterial conjunctivitis must be present for 3 days (approximately 72 hours) or less. * must be willing to discontinue contact lens wear for the duration of the study. exclusion criteria: * any uncontrolled, systemic, debilitating disease. * use of topical ophthalmic solutions including tear substitutes within 2 hours before and during the study. * use of any topical ophthalmic anti-inflammatory agents within 48 hours before and during the study. * any active upper respiratory tract infection. * pregnant or nursing females. * use of any antibiotic (topical or systemic) within 72 hours of enrollment

Keywords: bacterial conjunctivitis pink eye conjunctivitis eye infection eye discharge
effects of buteyko breathing exercise in children with uncontrolled asthma

Conditions: Breathing Techniques; Asthma Control Level; Asthma in Children; Asthma Patients; Breathing Exercise

Summary: this randomized controlled trial study aimed to measure the effectiveness of the combination of 4-weeks buteyko breathing exercises and pharmacological therapy compared with pharmacological therapy alone in children with uncontrolled asthma.


Eligibility criteria:
inclusion criteria: 1. children aged 7-17 years 2. uncontrolled or partially controlled asthma (gina symptom control tool score \> 1) 3. receive bronchodilator therapy, either oral or inhaler from a pediatrician. 4. children and parents/care givers agree to participate in the study until the end, and parents/care givers sign the informed consent form. 5. can understand instructions. exclusion criteria: 1. inpatients 2. have received buteyko breathing exercises or other breathing exercises. 3. have congenital heart disease, pneumonia, or other significant and uncontrolled health disorders. 4. have severe physical disabilities or mental retardation that could potentially prevent the implementation of buteyko breathing exercises. 5. have contraindications for spirometry examination

Keywords: asthma buteyko breathing retraining pediatrics