Kornimate/medical-research-clean huggingface dataset:
a new approach in laser surgery using the regenerative solution in children diagnosed with vascular pathology

Conditions: Vascular Diseases; Vascular Malformation; Capillary Malformation-Arteriovenous Malformation; Port-Wine Stain; Sturge-Weber Syndrome; Vascular Tumor

Summary: laser treatment (lt) is the first-line treatment for vascular pathology. however even when lt is based on the selective photothermolysis it causes the first-degree burns. while being typically benign by affecting only the epidermis, or outer layer of skin, the burn site is remaining red, dry, and very painful. as haemoblock contains nanoparticles of silver and is known for both bactericidal and bacteriostatic effects, it likely decreases the potential for infection postoperatively. furthermore, after fibrin replaces the superficial structure "hemoblock-albumin", the polyacrylate matrix is plasmolyzed which initiates the cascade of signals required for the tissue regeneration processes. objective of the study was to examine the effect of the regenerative solution "hemoblock" in lowering postoperative complications in children diagnosed with vascular pathology undergoing a laser surgery if delivered with transdermal patches.


Eligibility criteria:
inclusion criteria: * clinically diagnosed vascular pathology exclusion criteria: * age * severe allergic reaction

Keywords: vascular diseases laser treatment capillary malformation port-wine stain vascular tumor
comparison of the results of arthroscopic suturing of the medial meniscus using the fast fix and fiberstitch systems

Conditions: Meniscus; Detachment, Current Injury; Detachment; Medial Mensical Tear; Medial Meniscus Knee Injury

Summary: clinical and comparative evaluation of the treatment results of arthroscopic reconstruction of the medial meniscus of the knee joint using the fast fix and fiberstitch systems.

the main goal of the project is to evaluate the results of medial meniscus traumatic injury suturing. further (detailed) objectives are: to compare the results obtained in the study groups of suturing the medial meniscus with the use of two systems: fast fix (smith \& nephew) and fiber stitch (arthrex). the results refering to the operated limb will be compared in both groups between themselves and furthermore with the results of clinical and biomechanical studies on non-operated limbs.

Eligibility criteria:
inclusion criteria: * isolated mm damage. * operation performed only in arthroscopy technique. * no any knee intervention earlier. * no other pathology in the anatomical area. * patient informed consent to participate in research exclusion criteria: * age under 18 years old or above 35 years old. * any knee intervention performed earlier. * any other pathology in the anatomical area identified during preoperative diagnostics. * any damage in the area of the second knee joint. * failure complying the same treatment protocol rigor.

Keywords: meniscus; medial; injury; suture; techniques;
non-specific response to h1n1 vaccine

Conditions: Influenza H1N1

Summary: this is a prospective observational study with recruitment of healthy volunteers from consecutive recipients of h1n1 influenza vaccine at the university clinic of respiratory and allergic diseases, golnik, slovenia. the purpose of this study is to evaluate certain safety aspects of adjuvanted influenza h1n1 vaccines.


Eligibility criteria:
inclusion criteria: * recipients of h1n1 influenza vaccine. * healthy individuals with no signs of influenza or other infectious disease. exclusion criteria: * signs of influenza or other infectious disease in 1 month before study participation.

Keywords: influenza h1n1 vaccine adjuvant t lymphocytes non-specific response interleukin-2 non-specific t cell response
n-3 fatty acids for the prevention of atrial fibrillation in patients with acute heart failure

Conditions: Acute Heart Failure; Acute Myocardial Infarction

Summary: our study is to investigate the effect of n-3 fatty acids for the prevention of atrial fibrillation in patients with acute heart failure or acute myocardial infarction


Eligibility criteria:
inclusion criteria: * sinus rhythm patients with acute heart failure or acute myocardial infarction exclusion criteria: * pregnancy,allergy to epadel
annual study to investigate inactivated subunit influenza vaccine due to new virus strains for the southern hemisphere 2015 season

Conditions: Influenza

Summary: influenza (flu) viruses change continuously, therefore also the parts of viruses used in influenza vaccines can vary from year to year. the current study is a phase iii a clinical trial with a commercially available vaccine (influvac®) supplied in pre filled syringes. the objective of this study is to investigate the immunogenicity and safety and tolerability of the changed influenza vaccine virus composition in two groups of subjects in good health: subjects aged \>= 18 and \ = 61 years of age (elderly).


Eligibility criteria:
inclusion criteria: * willing and able to give informed consent and able to adhere to all protocol required study procedures. * men and women aged ≥ 18 and ≤ 60 years or ≥ 61 years of age at the day of study vaccination. * being in good health as judged by medical history, physical examination (if needed) and clinical judgment of the investigator exclusion criteria: * known to be allergic to eggs, chicken protein, gentamicin or any other constituent of the vaccine. * a serious adverse reaction after a previous (influenza) vaccination. * presence of any significant condition that may prohibit inclusion as determined by the investigator. * seasonal or pandemic influenza vaccination or laboratory confirmed seasonal or pandemic influenza infection within the previous six months before study vaccination or planned vaccination during the study period. * a history of guillain-barré syndrome or active neurological disease.

Keywords: influenza vaccine committee for medicinal products for human use (chmp) criteria
promoting resilience in early survivorship among adolescents and young adults with cancer

Conditions: Stress; Anxiety

Summary: the goal of this study is to find the best way to help participants and families manage the stress of facing a serious illness and be better able to "bounce back" or be resilient after a difficult situation. participants will take part in the "promoting resilience in stress management" prism program, which is designed to provide skills to change or improve the impact of stress in everyday life. the name of the intervention used in this research study is: -prism (a mobile app program comprised of 6 sessions of skills-based, manualized resilience education)

in this sequential, multiple assignment, randomized trial participants will be randomly selected to participate in prism program sessions with a trained research coach either by text or by video sessions, or participants will use the prism mobile app program in a self-guided way. randomization means the group participants are placed in will be decided by chance. all groups will continue to receive all the same care from primary medical, social work, and other care teams. in this two-stage study, participants will be randomly assigned to either the "app-only" (20% chance), "text" (40% chance) or "video" (40% chance) groups for the first stage. in the second stage, participants may be re-randomized again to the "app-only," or "text," groups, or will be referred to a specialty psychosocial support, social worker or counselor, based on responses to questionnaires. participants randomized to the "app-only" group in the first stage will not be re-randomized. the research study procedures include screening for eligibility and completion of questionnaires. participation in this research study is expected to last for up to 6 months. it is expected about 325 people will take part in this research study. the national institute for health (nih) is funding this research study.

Eligibility criteria:
participants that have completed their main cancer-directed therapy at one of the study sites affiliated centers who meet all the eligibility criteria will be eligible for participation in this study. inclusion criteria: * all genders ≥ 12 and ≤ 25 years of age at baseline * participant is able to speak english or spanish language (for prism sessions) * participant is able to read english or spanish language (for completion of surveys) * participant is cognitively able to participate in prism sessions and complete written questionnaires and surveys, as judged by the site investigator

Keywords: stress management
microbial community composition and metabolism in cystic fibrosis

Conditions: Cystic Fibrosis

Summary: scientist have begun to realize that many types of bacteria often live together as a complex community, and the investigators wish to apply that idea to the bacteria in the respiratory system of people with cystic fibrosis (cf). it is possible that the survival of the many millions of bacteria in the cf lung depends on the production of special chemicals that might be made only by very few types of bacteria. if that is true, medicines that interfere with those chemicals could treat the lung infections that cause trouble for nearly all people with cf. the investigators wish to study the production of several potentially critical chemicals by the respiratory bacteria and to examine the effect of those chemicals on the makeup of the entire community of bacteria. to detect all the bacteria in that community, the investigators will use new methods that use bacterial genetic information and can detect hundreds of different types of bacteria in respiratory samples of individual cf patients.


Eligibility criteria:
inclusion criteria: * confirmed diagnosis of cystic fibrosis * 2 to 55 years of age exclusion criteria: * none
rwd patients with pulmonary arterial hypertension treated with ip prostacyclin receptor agonists

Conditions: Pulmonary Arterial Hypertension

Summary: this is an observational, ambrispective study of patients in real world clinical practice, who has pulmonary arterial hypertension in whom a prostacyclin ip receptor agonist (selexipag) is initiated between 2017 and 2021. the aim of this study answer the following questions: * changes in the mortality risk profile of these patients after treatment administration. * baseline characteristics of patients initiating selexipag. * parameters used for risk stratification prior to treatment escalation. * events during follow-up. no comparison group available


Eligibility criteria:
inclusion criteria: * they agree to participate in the study by signing an informed consent form exclusion criteria: * decline to participate in the study * patients living 6 months or less in the reference health area * patients with active malignant tumors

Keywords: pulmonary arterial hypertension selexipag real world data effectiveness
conttribute: a global observational study of patients with transthyretin (ttr)-mediated amyloidosis (attr amyloidosis)

Conditions: Transthyretin-Mediated Amyloidosis; ATTR Amyloidosis

Summary: the purpose of this study is to: * describe epidemiological and clinical characteristics, natural history and real-world clinical management of attr amyloidosis patients * characterize the safety and effectiveness of patisiran and vutrisiran as part of routine clinical practice in the real-world clinical setting * describe disease emergence/progression in pre-symptomatic carriers of a known disease-causing transthyretin (ttr) variant


Eligibility criteria:
inclusion criteria: * diagnosis of attr amyloidosis or documented known disease-causing ttr variant for the cohort of pre-symptomatic carriers * germany only: patients must be treated per the summary of product characteristics (smpc) for any approved treatment for attr amyloidosis exclusion criteria: * current enrollment in a clinical trial for any investigational agent

Keywords: rnai therapeutic transthyretin ttr amyloidosis hereditary transthyretin-mediated (hattr) amyloidosis hattr amyloidosis hereditary attr amyloidosis wild-type amyloidosis wtattr amyloidosis attrv amyloidosis attrwt amyloidosis polyneuropathy familial amyloid polyneuropathies attr transthyretin amyloidosis ttr-mediated amyloidosis polyneuropathies amyloid neuropathies amyloid neuropathies, familial amyloidosis, familial
immunologic response to secukinumab in plaque psoriasis

Conditions: Psoriasis

Summary: this is a single-arm, open-label study, which will examine the effect of secukinumab on the immunologic and genetic environment within psoriatic lesions.

quantitative analysis of the immunologic changes in immune cell populations will be performed after secukinumab treatment in 15 patients at weeks 2, 4, and 12 compared to baseline week 0. the immunologic profiles in psoriasis patients will also be compared to healthy control skin surgical discard specimens (n=10). the number of differentially expressed genes in each cell population will be quantified by rna-seq at weeks 2, 4, 12 after secukinumab compared to baseline.

Eligibility criteria:
inclusion criteria: 1. ability to provide written informed consent and comply with the protocol. 2. at least 18 years of age. 3. diagnosis of predominately plaque psoriasis for at least 6 months prior to enrollment. 4. subject is considered a candidate for phototherapy or systemic therapy 5. pasi ≥ 12 6. pga ≥ 3 7. subject has a negative quantiferon gold, or if positive undergoes cxr. if cxr negative, subject initiated prophylactic therapy with isoniazid for a course of 9 months with one month of therapy completed prior to first dose of secukinumab. 8. subject is unlikely to conceive (male, post-menopausal, or using adequate oral contraceptive therapy or iud). 9. physical exam within clinically acceptable limits. exclusion criteria: 1. subject is unable to provide written informed consent or comply with the protocol. 2. subject is younger than 18 years of age. 3. subject has predominately non-plaque form of psoriasis. 4. subject with mild psoriasis (pasi\<12 and pga\<3) or is not a candidate for phototherapy or systemic treatments. 5. subject has drug-induced psoriasis. 6. subject with current, or a history of, severe psoriatic arthritis well controlled on current therapy. 7. subjects with a serum creatinine level exceeding 176.8 μmol/l (2.0 mg/dl). 8. screening total white blood cell (wbc count) \< 2,500/μl, platelets \< 100,000/μl, neutrophils \< 1,500/μl, or hemoglobin \<8.5 g/dl. 9. evidence of active tuberculosis infection as defined by a positive quantiferon tb-gold test (qft) with a positive chest x-ray at screening, or untreated latent tuberculosis defined by positive qft with a negative chest x-ray without prophylactic therapy with isoniazid for a course of 9 months with one month of therapy completed prior to first dose of secukinumab. 10. history of an ongoing, chronic or recurrent infectious disease including past medical history record of hiv, hepatitis b or hepatitis c. 11. subjects possess other diagnoses that, in the investigator's opinion, preclude him/her from safely participating in this study or interfere with the evaluation of the subject's psoriasis. 12. history of known or suspected intolerance to any of the ingredients of the investigational study product.
remote motivational interviewing to improve self-care in heart failure patients

Conditions: Heart Failure

Summary: the purpose of this study is to evaluate if motivational interviewing, performed remotely through videocalls, is effective to improve self-care in patients with heart failure

after signing the informed consent form, patients with heart failure will be assigned to the intervention or control group (1:1). the intervention group will receive a total of seven motivational interviewing sessions over 12 months. the control group will receive the standard care.

Eligibility criteria:
inclusion criteria: 1. a diagnosis of hf according to international guidelines; 2. class ii, iii or iv in the new york heart association (nyha) functional; 3. poor self-care, defined as at least two items of the self-care heart failure index 7.2 (schfi 7.2) with a score of 0, 1 or 2; 4. age ≥ 18 years; 5. having an internet access to allow the videocalls; 6. willingness to sign the informed consent form. - exclusion criteria: 1. severe cognitive dysfunction, with a score 0 - 4 on the six-item screener; 2. acute coronary events event in the prior three months; 3. living in nursing homes a residential settings where self-care cannot be performed; 4. if the patient's informal caregiver is not willing to participate in the study.

Keywords: heart failure motivational interviewing self-care self-management behavior change video calls
real-life second-line epirubicin-paclitaxel regimen as treatment of relapsed small-cell lung cancer : epitax study.

Conditions: Advanced Small Cell Lung Carcinoma

Summary: initial chemosensitivity is known concerning sclc but relapse is almost systematic, especially at a metastatic stage. brain metastasis are identified around 40 to 50% during the evolution of the disease. concerning the efficacy of epirubicin combined with paclitaxel from the second-line treatment, data is lacking more particularly about specific response on brain metastasis. in this retrospective multicentric observational study in real life conditions, we try to evaluate systemic and specific cerebral efficacy and safety of a regimen combining epirubicin and paclitaxel in patients treated between 2010 and 2020 for a small cell lung carcinoma from the second-line treatment.


Eligibility criteria:
inclusion criteria: * adults (age ≥18 years) * histologically or cytologically sclc diagnosis * treated with epirubicin-paclitaxel doublet between january 2010 and december 2020 exclusion criteria: * opposition to participate registered * patients under legal protection * patients afflicted by another subtype of lung carcinomas * sclc not treated with the epirubicin-paclitaxel doublet

Keywords: small-cell lung cancer epirubicin paclitaxel cerebral efficacy real-life
environmental influence on mental illness via modifications of genomes and metabolomes in adolescents with autism

Conditions: Autism; Autism Spectrum Disorder

Summary: the aim of the study is to enrich the understanding of the physiological mechanisms that predispose autistic adolescents to mental illness. it will inform a possible pathway and biomarker handprint of mental illness severity and prognosis to formulate a neurobiologically informed personalization strategy that could be applied for selecting appropriate evidence based intervention (ebi) for treating an adolescent formally diagnosed with autism.

the goal of this observational study is: 1. to identify environmental factors which may significantly contribute to the already vulnerable mental health of autistic adolescents in the age group of 11 - 15 years in developing mental illness; 2. to perform quantitative modelling of the epigenetic - genetic/metabolomic - mental health (egm) process chain for designing control strategies based on the subjects' personal, environmental, historical, and current state.

Eligibility criteria:
inclusion criteria: * autistic adolescents * must be able to interact verbally * parental consent and participants must be able and willing to give written informed assent and to comply with the requirements of the study protocol * must be willing to return for all study visits and wear the study device at home * must have access to and be able to operate a smartphone. exclusion criteria: * adolescents with severe motor impairments or schizophrenia * complex medical conditions, which would interfere with ability to take part in the study visits or outcomes. * intellectual disability, not capable to attend mainstream school
effectiveness of calcium and vitamin d, with and without collagen peptide, in enhancing bone mineral density on postmenopausal women with osteopenia

Conditions: Osteopenia

Summary: osteopenia is characterized by bone mineral density (bmd) being lower than normal but not reaching the osteoporosis threshold, poses a serious problem for women after menopause. osteopenia is a precursor to osteoporosis that is associated with increased risk of fractures, morbidity, and mortality. using strategies to improve or maintain bone density is important for preventing osteoporosis and its associated complications. the combination of collagen peptide (cp) with calcium and vitamin d supplementation may provide several ways to improve bone health. this study aims to provide preliminary evidence of the effectiveness of traditional medicine in improving bone health through the effectiveness of cp.

osteopenia is characterized by bone mineral density (bmd) being lower than normal but not reaching the osteoporosis threshold, poses a serious problem for women after menopause. osteopenia is a precursor to osteoporosis that is associated with increased risk of fractures, morbidity, and mortality. using strategies to improve or maintain bone density is important for preventing osteoporosis and its associated complications. the combination of collagen peptide (cp) with calcium and vitamin d supplementation may provide several ways to improve bone health. this study aims to provide preliminary evidence of the effectiveness of traditional medicine in improving bone health through the effectiveness of cp.the study was single blinded randomized controlled trial, involving 30 post-menopausal women that were equally divided into two groups by computer generated simple random sampling technique. group a received bioactive collagen peptide along with calcium lactate, and vitamin d3. the control group (group b) consisted of 15 participants who were given a chewable tablet daily, containing 1.25 grams of calcium carbonate (equivalent to 500 mg of elemental calcium) and 400 iu of vitamin d3.

Eligibility criteria:
inclusion criteria: * postmenopausal patients * (-1. 0\>t-score\>-2. 5) exclusion criteria: * fracture, * primary hyperparathyroidism

Keywords: bone mineral density collagen peptide osteoporosis osteopenia vitamin d3
acupuncture to managed pain during induced labor with cook's balloon

Conditions: Labor Induction

Summary: in france, labor induction rate is above 25.8%. labor induction with cook's balloon is a non-hormonal mechanical method but this technique can provide pain. at roubaix's maternity, midewifes can adminitred acupuncture therapy to help to manage this pain. no studies where found about an effect of acupuncture therapy on pain provoked by labor induction with cook's balloon.

investigators aim to demonstate that acupuncture therapy during labor induction with cook's balloon can reduced pain and improved patient's experience. investigators will use 7 acupuncture points (yin tang/ 4 gi bilateral/ 36 e bilateral and 5tr bilateral) before the application of the balloon. a visual analog scale will be used before and after balloon insertion to collect pain level. a questionnary will be filled by patient to collect their experiences. investigators will collect data about analgesia, failed of induction and cesarean section to see effect of acupuncture on them. patients will be randomised.

Eligibility criteria:
inclusion criteria: * pregnant woman with a gestational age of 37 weeks and above * age\>=18 years old * having medical indication to be labor induced by cook's balloon * speaking french * agreeing to participate by signing informed consent form exclusion criteria: * patient having contraindication for the use of cook's balloon * patients under curatorship and/or guardianship

Keywords: acupuncture therapy labor induction pain management