Kornimate/medical-research-clean huggingface dataset:
long-term survival with hiv: psychological and behavioral factors associated with the transition from adolescence to young adulthood

Conditions: HIV Infection

Summary: this study will examine the emotional and behavioral aspects of long-term survival of hiv/aids among adolescents and young adults with hiv infection. hiv-infected individuals between 13 and 23 years of age may be eligible for this study. they must be aware of their hiv diagnosis, have been infected for at least 13 years and have been on an active nih protocol during the past 5 years. in addition to the usual stresses of growing up, children with hiv infection may have spent much of their time in hospitals and may have lost parents, friends and other loved ones. this study will explore psychological aspects of growing up with hiv, including self esteem, possible risk behaviors, how disclosure to others changes over time, the commonness of anxiety and depression, and the impact that losses have had on the adolescents' emotional health. to gather this information, participants will be interviewed and asked to fill out a set of forms. caregivers will also fill out forms. patients who are not currently on an active nih protocol will have the option of having a physical examination and routine blood work. the results will be sent to their home care provider.

children and adolescents with hiv/aids are living well beyond the life expectancy that was projected for them in the past. as the number of survivors of vertically or transfusion associated pediatric hiv disease increases, attention to the psychosocial adjustment of these adolescents and young adults becomes increasingly important. studies in the late 1990s described child and adolescent survivors as generally well adjusted, though difficulties become more apparent as the child approached the age of 18. nothing is known about these hiv positive youngsters as they enter late adolescence and young adulthood. this study will examine psychosocial factors associated with long-term survival of hiv/aids, including the prevalence of psychiatric diagnoses, risk behaviors, evaluation of self competence, and the impact that multiple losses has on the adolescents' emotional well-being. in addition, data will be collected from the primary caregivers on the prevalence of parenting stress compared to national norms. subjects will include children who have been infected (either perinatally or through transfusion) for at least eight years and who are aware of their diagnosis.

Eligibility criteria:
inclusion criteria hiv-infected adolescents 13-24 years of age with documented hiv infection for greater than or equal to 13 years. on active protocol at nih during the past 5 years. willingness to sign informed consent. ability to understand and read english. exclusion criteria presence of psychotic symptoms. cognitive impairment or full scale iq less than or equal to 75. not aware of hiv diagnosis.

Keywords: hiv infection mental health risk behaviors post-traumatic stress disorder youth hiv long term survivor
preemptive versus preventive antiemetic treatment

Conditions: Postoperative Nausea and Vomiting

Summary: patients aged between 20 and 70 years, asa physical status i-iii, and scheduled for laparoscopic cholecystectomy under general anaesthesia will be enrolled in the study. patients will be randomized to the preemptive group to receive an antiemetic regime 1h before the start of surgery or to the intraoperative group to receive the same antiemetic drugs in the same doses intraoperatively, 30 min before the end of surgery. in the operating room standard monitoring and a standardized anesthetic technique will be implemented in all patients. nausea, vomiting, retching and ponv (cumulative) will be recorded at pacu, at 4h, 8h and 24h postoperatively. pain scores assessed by nrs (numerical rating scale) will be recorded at the same time points. also, when patients received fluids and solid food by mouth will be recorded.


Eligibility criteria:
inclusion criteria: * asa physical status i-iii patients * surgical procedure: scheduled for laparoscopic cholecystectomy * type of anesthesia: general exclusion criteria: * antihistamines the last three days * antiemetic drugs the last three days * hiatus hernia * reflux * gastrointestinal disease * pregnancy * bmi \> 35 * parkinson * known allergy to the drugs of the protocol * epilepsy
the effect of various external pressure on blood

Conditions: Hemorrhage

Summary: rapid infusion of blood is needed occasionally for control massive bleeding. for rapid infusion, external pressure can be used. the investigators will study correlation between external pressure and hemolysis and deformability of red blood cell.

rapid infusion of blood is needed occasionally for control massive bleeding. for rapid infusion, external pressure can be used which cause hemolysis and alteration of red blood cell. the investigators will study correlation between variable external pressure and hemolysis and deformability of red blood cell. differ from previous study, the investigator will use scanning electron microscope for observation red blood cell.

Eligibility criteria:
inclusion criteria: * healthy volunteers, without any underlying disease. exclusion criteria: * history of delivery, abortion in past 6 months. * weight : male under 50kg, female under 45kg * heart rate under 50 or over 100 * fever : over 37.5 * blood pressure : over 180/100
visual impairment, oscillopsia and multiple sclerosis

Conditions: Multiple Sclerosis

Summary: this study consists of two parts. the first part is a survey to examine vision-specific health-related quality of life in a cohort of patients with multiple sclerosis. we test visual impairment like visual acuity, visual field, colour discrimination, contrast sensitivity, eye movement. the aim of this part is to examine the association between responses to the quality of life scale and objective measures of visual impairment. the second part is an open controlled study, in which we measure motion detection threshold in ms patients with oscillopsia due to pendular nystagmus and in a group of control subjects. the objective of this part is to determine whether patients with pendular nystagmus develop adaptation to oscillopsia using increased threshold of motion detection. we plan to test the effect of visuo-motor rehabilitation on this threshold in patients with oscillopsia due to pendular nystagmus.

in the first part, 100 patients with multiple sclerosis are included. a vision-specific health-related quality of life scale and neuro-ophthalmological tests are administered. the duration of intervention is about 3 hours by patient and one year to finish this part. in the second part, we include about 40 of 100 ms patients who present an oscillopsia due to pendular nystagmus and a group of 20 control subjects. the patients and subject will perform a motion detection task and the vision-specific health-related quality of life, the intervention lasting 1 hour. then the patients will be randomized in one group treated by rehabilitation (one 30 mn session per week during 3 months) and the other one without treatment. a motion detection task and the vision-specific health-related quality of life scale will be performed at the end of the treatment for both groups.

Eligibility criteria:
inclusion criteria: * age 18 to 90 * patients with established multiple sclerosis * visual impairment recovering from ms * understanding rules task * patient can stay set a long time * patient's agreement * membership to the social security * no relapsing since three months exclusion criteria: * brain damage * cognitive or behaviour disorder * patients with peripheral vestibular, otologic or ophthalmologic pathology antecedent * not stabilized disease (other one than ms) * patient under guardianship

Keywords: multiples sclerosis oscillopsia eye movements motion detection retinal slip nystagmus
disparity driven vergence in mild traumatic brain injury (mtbi)

Conditions: Mild Traumatic Brain Injury

Summary: this study aims to determine the validity and safety of disparity driven vergence using a portable goggle system (i-pas) using a pseudorandom ternary sequence of frequencies for testing.


Eligibility criteria:
inclusion criteria: * age 18 to 65 * both females and males exclusion criteria: * central processing disorder * impaired vision without corrective lenses (max 20/60 uncorrected) * moderate to severe hearing loss (\>55 decibels (db) pure tone audiometry (pta), \<50% word identification) * vestibular disorder except for patients recruited for subjects recruited with a history of mild traumatic brain injury to compare to normal participants * history of ear surgery other than myringotomy with or without tube placement * pregnant women * prisoners * adults unable to consent

Keywords: mtbi tbi brain injury concussion
exercise for young adults with cancer

Conditions: Fatigue; Cancer; Physical Activity; Exercise

Summary: over the past decade, importance of supportive care in cancer treatment of young cancer patients has increased. however, most common cancer-related side effects, such as physical deconditioning, psychological problems, infertility, and cancer-related fatigue, are particularly problematic for young adults (aya). short- and long-term side effects result in impaired quality of life, social life, and physical activity levels. while there is growing evidence that physical exercise is effective in reducing disease- or treatment-related side effects, programs are generally not tailored to the unique needs of young adults. in addition, social media or web-based programs are rarely structurally integrated into existing care programs. the objective of the your exercise program (youex) study is therefore to address these specific needs and to improve physical exercise services for young people in germany. to this end, this pilot study presents three approaches to physical activity enhancement, with a particular focus on web-based and cross-regional programs. all three approaches will be evaluated for their feasibility and effectiveness on fatigue, distress, quality of life, and activity levels, as well as sustained effects over 24 weeks. the youex study is an exploratory intervention study in the form of a 12-week exercise program for patients aged 18 to 39 years who currently have or have had a cancer diagnosis within the past 5 years. eligible patients can choose from three support programs: social media exercise program, online exercise platform, supervised exercise program. the goal is to recruit 70 to 80 patients over an 8-month period. evaluation questionnaires will be sent at three time points (t0: start of exercise program, t1: after 6 weeks; t2: after 12 weeks; t3: after 24 weeks) with a short weekly questionnaire between t0 and t2 to assess weekly adherence and changes in fatigue. youex study will collect detailed information on the acceptability and feasibility of different physical activity programs for young people and their lasting effects on fatigue, quality of life and physical activity. should these be positive, the findings can directly inform health care practice, which would be highly relevant especially in light of the covid pandemic.


Eligibility criteria:
inclusion criteria: * cancer diagnosis within the past five years * signed informed consent exclusion criteria: * cancer-related cognitive impairment * lack of sports clearance from the attending oncologist (e.g. in case of fragile bone metastases) * current participation in another exercise intervention * insufficient german language skills

Keywords: cancer social media exercise virtual training app
a pilot study of neurocysticercosis treatment

Conditions: Neurocysticercosis

Summary: the purpose of this study is to determine if treatment with albendazole improves the clinical outcome of neurocysticercosis infection and/or leads to the disappearance of cysts sooner when compared with symptomatic treatment.

neurocysticercosis-a disease in which a young tapeworm infects the brain-is common in much of the developing world. it affects approximately 1 out of every 10 people in the united states and is said to be the primary cause of adult-onset epilepsy. the infection creates cysts in the brain, causing seizures and headaches among other symptoms. to date no successful preventive treatment for neurocysticercosis exists. at present, medicines that kill the adult tapeworm in the stomach and intestines are also used to treat neurocysticercosis caused by the young tapeworm. however, in cases of neurocysticercosis, the methods of administration, doses, and duration of treatment with these medicines still have not been determined. although these medicines may kill the worm in the brain more rapidly than the natural mechanisms of the body, the long-term benefit of using the medicines to eliminate the worms after the first 1 or 2 months is not clear. in addition, the drugs that kill the worm may be associated with in increased seizures and headache during treatment, and may cause inflammation of the meninges-the covering of the brain-leading to symptoms that may require surgery. the goal of this trial is to determine if treatment with the antiparasitic agent albendazole improves the outcome of neurocysticercosis infection. this trial will also determine if albendazole leads to the disappearance of cysts sooner when compared with symptomatic treatment. participants will be randomly assigned to receive either the study medication, albendazol, or a placebo, an inactive substance, for an 8-day inpatient or outpatient therapy period. additionally, all participants will receive prednisolone, a corticosteroid, as well as other medications. participants will remain under the care of a doctor for 2 years and will have regularly scheduled visits and testing. information learned in this study may lead to improved treatment of neurocysticercosis.

Eligibility criteria:
inclusion criteria: * patients presenting with new onset of symptoms associated with neurocysticercosis within two months of identification and have active and/or transitional neurocysticercosis cysts on computed tomography (ct) or magnetic resonance imaging (mri) exclusion criteria: * patients with only calcifications * patients who are pregnant * patients with one of the following conditions: papilledema, active tuberculosis, syphilis, ocular cysticercosis, active gastric ulcers, or a progressive and life-threatening disorder * patients who received anthelmintic drugs (ahd) during the year preceding presentation or who received steroids within 30 days of presentation

Keywords: neurocysticercosis albendazole tape worm
wrap north america

Conditions: Venous Stenosis; Venous Occlusion

Summary: the goal of this observational study is to investigate the safety and efficacy of the wrapsody cie in a real-world north american population. participants treated with the wrapsody cie device in accordance with the device instructions for use will be followed in accordance with standard of care up to 3-years post-procedure.

prospective, multicenter, observational study to evaluate the merit wrapsody® cell impermeable endoprosthesis for treatment of stenosis or occlusion within the dialysis outflow circuit (wrap north america)

Eligibility criteria:
inclusion criteria: 1. subject provides written informed consent for study participation. 2. subject is male or female, with an age ≥ 18 years at date of enrollment. 3. subject is willing to comply with site standard of care procedures and follow-up visit schedules over 36 months. 4. subject is undergoing chronic hemodialysis with the hemodialysis access the intervention will be performed upon. 5. the dialysis access is considered mature and has been used to deliver hemodialysis treatments for at least one session. 6. subject has stenosis or occlusion within the dialysis outflow circuit and is treated with wrapsody cie in accordance with device instructions for use. exclusion criteria: 1. subject has a planned surgical revision of access site. 2. subject has a known or suspected infection of the hemodialysis access site, systemic infection and/or septicemia. 3. subject has an uncorrectable coagulation disorder. 4. known hypersensitivity to nickel or titanium. 5. subject's hemodialysis access is anticipated to be abandoned within 6 months. 6. subject is scheduled for kidney transplant or peritoneal dialysis within the next 6 months post-procedure. 7. full expansion of a pta balloon cannot be achieved during predilatation. 8. device would be placed in the superior vena cava 9. any inflow or outflow lesion that could jeopardize patency access long-term beyond the target treatment area.

Keywords: arteriovenous fistula (avf) arteriovenous graft (avg) av fistula av graft
a multicenter study of anlotinib in hepatocellular carcinoma (hcc) patients at high risk of post surgery recurrence

Conditions: Hepatocellular Carcinoma

Summary: to assess the primary effects and safety of anlotinib in hcc patients at high risk of post surgery recurrence.

hepatocellular carcinoma is one of the most common malignant tumors in the world with high incidence and mortality. recurrence of hcc is still a great challenge and threat to the patients after resection surgery. anlotinib is a new, orally administered tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (vegfr), fibroblast growth factor receptor (fgfr), platelet-derived growth factor receptors (pdgfr), and c-kit. hcc patients who meet the eligibility criteria of this clinical trial will be administrated anlotinib 12mg qd po d1-14, 21 days per cycle. the disease free survival (dfs), overall survival (os) and any adverse effect during the 8 cycles of anlotinib treatment will be evaluated in order to assess the primary effects and safety of anlotinib in hcc patients at high risk of post surgery recurrence.

Eligibility criteria:
inclusion criteria: * no allergic history of anlotinib * 18-75 years * no history of severe arrhythmia or heart failure * no history of severe ventilation dysfunction or severe pulmonary infection * no acute or chronic renal failure, creatinine clearance \> 40 ml/min * liver function is normal: child-pugh grade a or grade b (≤7 points), total bilirubin ≤ 3.0 mg/dl, albumin ≥ 28 g/l, ast, alt, alp≤ 5 times of the upper limit of normal value * blood test: the absolute neutrophil count ≥ 1.5×10\^9 /l, hb ≥ 8.5 g/l, plt ≥ 75×10\^9 /l (without blood transfusions and drug therapy 14 days before the screening) * blood coagulation function: inr≤2.3 * ecog: 0-2 * pathology: hepatocellular carcinoma * satisfy any of the following: a. portal vein, hepatic vein or bile duct carcinoma thrombus b. microvascular invasion (mvi) grade ii (\> 5 mvi, or mvi occurs in the area more than 1 cm from the tumor) c. tumor number ≥ 3 d. preoperative rupture of tumor or tumor invasion adjacent organs * patients participate in the study voluntarily and sign informed consent exclusion criteria: * pregnant or lactating women * patients who have had or are currently complicated with other malignant tumors * recurrent hepatocellular carcinoma * patients who participated in other clinical trials within 1 month * patients with mental illness * patients treated with targeted drugs, immunotherapy (such as pd1 antibody), folfox systemic chemotherapy or huaier granules after surgery * urine protein ≥ ++，and 24-hour urinary protein excretion\>1.0 g confirmed
burn out and quality of life at french general practioners

Conditions: Cross-Sectional Studies

Summary: the suffering of caregivers is constantly increasing. general medicine, because of its primary role in primary care, is particularly exposed to the risk of burn-out and must protect itself. the aim of this study was to find an inverse relationship between health-related quality of life and being severely burned by french general practitioners.

descriptive quantitative cross-sectional study

Eligibility criteria:
inclusion criteria: * french general practitioner in liberal activity exclusion criteria: * retired doctor * junior general practioner

Keywords: burn out quality of life general practioners french
the experiences of patients living with malignant pleural effusions

Conditions: Malignant Pleural Effusion

Summary: up to 20 patients with malignant pleural effusions will be interviewed about their experiences of having this condition and its management.


Eligibility criteria:
inclusion criteria: 1. adults diagnosed with a malignant pleural effusion 2. has undergone either talc pleurodesis or ipc 3. have signed a consent form prior to entering the study 4. life expectancy \> 6 weeks based on lent guidelines (low/moderate risk group) - the lent score calculation assigns 0 (\ 1500 iu/l) for pleural fluid ldh level; 0 to 3 points for matching ecog performance scores (3 and 4 are combined); 0 (\ 9) for neutrophil-to-lymphocyte ratio; and 0 (lowest risk), 1 (moderate risk), or 3 (highest risk) for tumor type. exclusion criteria: 1. any patient who is unable to understand sufficient english to take part in the semi-structured interviews 2. weakness or fatigue sufficient so that the patient is unable to take part in the interviews
effect of intraoperative dexamethasone on post-op dry eye

Conditions: Dry Eye Syndromes

Summary: to compare the signs and symptoms of dry eye after cataract surgery between subjects randomized to receive intraoperative dexamethasone in addition to the use of a standard topical post-op treatment regimen.

forty patients requiring cataract surgery will be randomized to treatment of post-operative inflammation with a single intraoperative dexamethasone injection plus a standard course of topical ophthalmic corticosteroid drops or the standard treatment alone. dry eye testing will be administered at baseline, 1 week and 3 weeks following surgery.

Eligibility criteria:
inclusion criteria: * undergoing bilateral cataract surgery exclusion criteria: * central corneal staining with fluorescein and/or a tear film osmolarity of greater than 340 in either eye
evaluation of serratus plane block on the respiratory pattern in patients with multiple rib fractures

Conditions: Rib Fractures; Spirometry

Summary: in patients admitted following a trauma, the incidence of multiple rib fractures is reported to be 9,7%, and this can be even higher in high energy trauma like motor vehicle accidents (1). pain deriving from rib fractures cause the patient to breath shallow in order to limit discomfort and this bring about negative consequences: shallow breathing and inability to clear secretions may cause pulmonary atelectasis eventually evolving to pneumonia. given the aforementioned concerns, it is easy to understand why, in a context like this, control of chest pain become crucial. the best way to achieve adequate pain control have not yet been established: the aim of this study is to investigate on this clinical dilemma. in this study, 72 people with at least two monolateral rib fractures are going to be randomized into three groups: 1) standard treatment alone (intravenous analgesia: acetaminophen + morphine pca); 2) continuous serratus plane block + standard treatment; 3) single-shot serratus plane block + standard treatment. the variables that are going to be recorded are the following: pain through the nrs scale, fev1 and fvc through spirometry and finally an arterious gas analysis. recording are going to be repeated at 72h after admission. the primary endpoint is to evaluate if the continuous serratus plane block is able to improve the fev1/fvc compared to single shot or standard treatment alone. secondary endpoints will be: the effect of continuous block on 1) resting and incident pain; 2) opioid consumption; 3) blood gas analysis parameters; 4) pulmonary complications at 1 month; 5) length of stay


Eligibility criteria:
inclusion criteria: 1. chest trauma with at least 2 monolateral rib fractures (monofocal or multifocal) with no flail chest 2. age\>18 years 3. hospital admission 4. ability to provide written informed consensus 5. awake patient, spontaneous ventilation