Kornimate/medical-research-clean huggingface dataset:
the adding value of parents to nursing care in the control of fio2

Conditions: Premature Birth of Newborn

Summary: the purpose of this study is to determine whether saturation control by parents in children younger than 32 weeks or under 1500 g versus conventional care performed by nursing increases the time in which these patients remain at optimal saturation range. if the hypothesis of this study is confirmed premature infants could prevent episodes of hypoxia-hyperoxia and also give more relevance to the role of parents in caring for their children admitted in a neonatal intensive care unit.

both episodes of hyperoxia and hypoxemia in preterm infants increase morbidity and mortality. nowadays the adjustment of fio2 is manually controlled, which means it depends on the staff, needing multiple adjustments throughout the day. the investigators's hypothesis is that the fio2 control by parents, improve the percentage of time in range of optimum saturation at least 10% compared to control by nurses. the aim of this study is to compare the proportion of time with oxygen saturation (spo2) within the assigned target range, in the preterm infants whose parents modify the fraction of inspired oxygen (fio2) versus the nursing staff modifying group. this is a randomized controlled clinical study in the neonatal intensive care unit at hospital 12 de octubre. patients will be randomized in two groups, experimental group: parents controlling the saturation ranges, they will manually adjust fio2 versus the control group: controlled by nursing staff (standard procedure). saturations will be registered and adjustments of fio2 will be filmed for nonconsecutive 20-hours periods. twenty-three patients will be enrolled in each group.

Eligibility criteria:
inclusion criteria: * related to child * preterm neonates less than 32 weeks or less than 1500 g hospitalized in the neonatal intensive care unit at hospital 12 de octubre. * receiving supplemental oxygen ≤0.4 administered by cpap or conventional nasal cannula or high flow or children with bipap (flow generator with double level pressure) * minimum age 7 days old. * related to the mother: * absence of health problems that allows her to perform the task. * availability to frequently visit her baby with the father or with a companion, at least for 20 hours, not consecutive. * understanding of the study and the spanish language by the mother and father or companion. * signed informed consent. exclusion criteria: * evidence of pneumothorax or pneumomediastinum. * non-compliance with study protocol. * requiring treatment with vasoactive drugs.
a study on vertebral bone strength by micro-ct-like image

Conditions: Osteoporosis

Summary: in this study, we use conditional generation adversarial network to enhance the resolution of msct images and obtain micro-ct-like images. based on this, we measure the bone structure indexes of micro-ct-like images and analyzed the correlation between bone structure and bio-mechanical indexes.

in this study, we expect to collect 10 sets of vertebrae (between t6 and l5) from 10 formalin-fixed human cadavers. the study protocol was reviewed and approved by the local institutional review boards.the collected specimens subject to normalized micro-ct and msct image scanning, image reconstruction using standard algorithms, and bone structure observation using bone algorithms to obtain high-quality, standardized axial images. we will use a conditional generation adversarial network-based image mapping technique to train the mapping model between msct images and micro-ct images, find the correspondence between the image information contained in each of msct and micro-ct, and finally obtain high-resolution micro-ct-like images. after obtaining the micro-ct-like images of the samples, we will segment and annotate the images (including different structures such as vertebral body, bone cortex) and train the teacher-student \& u-net++ deep learning architecture to achieve accurate segmentation of vertebral body regions, and obtain cancellous bone regions of interest. based on this, we will analyze the bone structure characteristics of each spatial region in the images, including the thickness, spacing, orientation and distribution pattern of bone trabeculae and other indicators. ultimately, we will cut a standardized cubic sample from the vertebral cancellous bone , obtain the bio-mechanical performance index of this cancellous bone sample by mechanical experiments, and analyze the correlation between bone structure of micro-ct-like images and bio-mechanical index.

Eligibility criteria:
inclusion criteria: * we will collect human formalin-fixed vertebral specimens provided by the department of anatomy, peking university school of medicine. the expected number of enrolled specimens is approximately 100 vertebrae (between t6 and l5) . exclusion criteria: * the vertebrae with significant compression fractures, bone neoplasms, or other causes of significant bone destruction.
format of patient education for different sociodemographic groups

Conditions: Type2 Diabetes Mellitus; Cardiovascular Diseases

Summary: questionnaire study to investigate the effect of individual characteristics such as age, sex, ethnicity, educational level and socioeconomic status on the preferred format of patient education delivery, for patients with diabetes and/or cardiovascular disease

an anonymous questionnaire will be used to collect basic demographic data for patients with the conditions of interest, in addition to information about their preferences for the format in which they receive patient education information. this data will be statistically analysed to address the primary and secondary outcomes of the study: 1. to investigate the effect of individual characteristics such as age, sex, ethnicity, educational level and socioeconomic status on the preferred format of patient education delivery. 2. to identify reasons for preference of patient education delivery, and whether these are associated with sociodemographic factors. 3. to assess the distribution of sociodemographic factors from participants who prefer online education, in order to identify whether preference for online education is associated with particular sociodemographic factors.

Eligibility criteria:
inclusion criteria: * aged 18 years or over. * diagnosed with cardiovascular disease (defined as heart disease, peripheral vascular disease or stroke) or type 2 diabetes * has not already completed the questionnaire * able and willing to complete questionnaire exclusion criteria: * participant unable or unwilling to complete questionnaire * under the age of 18 * not diagnosed with any of the conditions of interest * participant has already completed the questionnaire * unable to communicate (assisted or otherwise) in written english
acetylsalicylic acid and type 2 diabetes mellitus

Conditions: Diabetes Mellitus, Type 2; Antioxidant Enzyme System

Summary: objetive to assess the effect of acetylsalicylic acid on antioxidant enzymatic system in patients with type 2 diabetes

a randomized, double blind placebo controlled clinical trial was carried out in 21 adult patients with type 2 diabetes. acetylsalicylic acid 300mg/d was administered orally for 3 months to study group (n=11) and placebo to the control group (n=10).

Eligibility criteria:
inclusion criteria: * type 2 diabetes * bmi 25.0 - 35.0 kg/m2 * hba1c between 6.5 - 9%. * written informed consent * same residential area and socioeconomic status. exclusion criteria: * sedentary or heavy physical activity. * nonsmokers. * body weight was stable for al last 3 months before the study. * personal history of hepatic, renal, gastric or coronary artery disease. * hypersensibility to acetylsalicylic acid.

Keywords: acetylsalicylic acid antioxidant enzyme system stress oxidative type 2 diabetes mellitus.
effects of curcumin-containing toothpaste on dental biofilm and associated oral halitosis

Conditions: Halitosis

Summary: purpose: to investigate the short-term clinical effect of curcumin-containing toothpaste on halitosis as compared to placebo and to assess potential shifts in the composition of dental biofilm associated with the use of curcumin-containing toothpaste participants: this clinical study will 30 adult participants under prophylactic or periodontal maintenance protocol. procedures (methods): participants will be included and throughout the protocol will not allow the use any other oral hygiene products except standard manual toothbrush and study toothpaste (either test -curcumin-containing or placebo). additionally participants will be instructed to odiferous foods such as onions, garlic and spices. at each of the three examination sessions, plaque index (six sites, o'leary) and volatile sulphur compounds (vsc) will be measured.


Eligibility criteria:
inclusion criteria * participants must be adult males or females between the ages of 18 and 65 years (inclusive) reporting halitosis * participants must be able and willing to follow study procedures and instructions * participants must have read, understood and signed an informed consent form * participants must present with at least 8 teeth in the functional dentition and with at least 4 teeth in each posterior sextant, 3 of which are adjacent teeth with interproximal papilla in each posterior sextant that will have the stent * participants must be in good general health exclusion criteria * patients ongoing restorative or periodontal dental treatment or any other medical treatment * subjects with any pathological alterations of the oral mucosa * any known allergy to previously used oral hygiene products or any known allergy to any of the ingredients of the study products, which are used during the study * pregnant women * subjects with untreated periodontitis or active caries lesion * subjects diagnosed with acute sinusitis, bronchitis or tonsillitis * subjects under treatment on medications which can cause malodor, e.g. amphetamines, nitrates and nitrites * known diabetes, liver or kidney insufficiency * subjects diagnosed with reduced salivary flow due to pathological reasons (e.g. sjögren syndrome) * subjects who underwent preventive periodontal treatment, i.e. oral prophylaxis treatment, within the last week * volunteers unwilling to abstain from additional oral hygiene (only tooth brushing allowed) particularly mouthrinse, chewing gums, breath strips, etc and alcohol 12 h prior the first measurement at the study site and until the completion of all measurements
a study to evaluate caregiver connections via technology for patients with alzheimer's and other types of dementia

Conditions: Caregiver Stress; Dementia; Alzheimer Dementia; Lewy Body Dementia; Parkinson Disease Dementia; Frontotemporal Dementia

Summary: this research is being done to develop a unique matching process for caregivers of persons living with dementia, such as alzheimer's disease, lewy body dementia, frontotemporal degeneration, or other dementia syndromes. dementia caregivers often assume greater caregiving burden than do non-dementia caregivers, and the caregiving duration tends to be longer. many caregivers do not have the adequate support they need. peer-to-peer support has been shown to improve quality of life, increase use of services, improve caregiver health, and reduce hospitalizations in the person they are caring for. this study will assess a technology platform and matching process for the purpose of peer-to-peer emotional support aimed at improving overall wellbeing in dementia care partners/caregivers.


Eligibility criteria:
individuals in a current or former caregiving role for a family member living with dementia will be recruited for this study. there will be no sex or gender restrictions, or exclusion based on race or ethnicity. participants must be at least 18 years of age. inclusion criteria: * the participant must have a family member that has been diagnosed with dementia. * the participant must identify as a care partner or caregiver who has contact with their loved one with dementia, in person or by phone, and who provides social/emotional support and full or partial assistance with daily activities at least 3 days per week. * the participant must have been caring for their loved one with dementia for at least 3 months. * all participants must have access to a computer and be able to use the internet. * all participants must be english speaking. * all participants must agree to participate in the 15-month study, which includes completing questionnaires, brief "virtual" interactions with the study coordinator quarterly, and actively interacting with the website and potential matches. * all participants must agree to follow-up contact throughout the duration of the study, which is anticipated to last 3 years. exclusion criteria: * care partner's loved one does not have a confirmed diagnosis of dementia. * care partner is unable to provide consent. * care partner was or has been in that role for less than 3 months.
the difference in the biological characteristic characteristics of the heart and lung meridians

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the association between viscera and the body surface remains obscure, but a better understanding of it will maximize its diagnostic and therapeutic values in clinical practice. therefore, this study aimed to investigate the specificity of the association between viscera and the body surface in the pathological state.

study subjects included 40 chronic obstructive pulmonary disease (copd) participants in the copd group and 40 age-matched healthy participants in the healthy control group. laser doppler flowmetry, infrared thermography, and functional near-infrared spectroscopy were respectively adopted to measure (1) the perfusion unit (pu), (2) temperature, and (3) regional oxygen saturation (rso2) of 4 specific somatic sites distributing in the heart and lung meridians. these 3 outcome measures reflected the microcirculatory, thermal and metabolic characteristics of the body surface, respectively.

Eligibility criteria:
inclusion criteria: * copd participants were eligible if they 1) satisfied the diagnostic criteria of copd; 2) were in the stable phase of copd; 3) were 20 ≤ age ≤ 75 years; 4) fully understood the study protocol and signed the written informed consent. healthy participants were eligible if they 1) were healthy subjects who provided a medical examination report within 6 preceding months for confirming their health conditions; 2) were age-matched with the copd group; 3) fully understood the study protocol and signed the written informed consent. exclusion criteria: * copd patients were excluded if they 1) had other major lung diseases, such as bronchiectasis, pneumothorax, and lung tumors; 2) had concomitant heart diseases; 3) had serious concomitant diseases in major systems that were not controlled effectively 4) had mental diseases, history of drug abuse, and alcohol dependence; 5) were lactating or pregnant and 6)had scarring, hyperpigmentation, redness, swelling and heat in the skin around the measurement sites, which would affect the accuracy of examinations. healthy subjects were excluded if they 1) had mental illness, history of drug abuse and alcohol dependence; 2) were lactating or pregnant; 3) had scarring, hyperpigmentation, redness, swelling, and heat in the skin around the measurement sites, which would affect the accuracy of examinations.

Keywords: acupuncture meridians biological characteristic
the effect of aerobic exercises and yoga exercises in axial spondyloarthritis

Conditions: Axial Spondyloarthritis and Ankylosing Spondylitis

Summary: axial spondyloarthritis (axspa), mainly affecting the axial skeleton and sacroiliac joints, is a chronic, systemic, inflammatory disease that causes structural and functional disorders. exercise has a significant role to play in managing treatments. this study aimed to determine the effect of yoga-based exercises combined with aerobic exercise on spinal mobility, disease activity and aerobic capacity in axspa.

the study included 60 axspa patients according to asas criteria. patients will be divided into two groups randomised. group 1 (n=30) received only aerobic exercise, group 2 (n=30) received aerobic exercise and yoga exercises will be applied. aerobic exercise intensity will be measured by cardiopulmonary exercise test (cpet). determined. aerobic exercises will be performed with a lower extremity ergometer for 30 minutes and 12 sessions. in group 2, in addition to aerobic exercises, spinal stretching, relaxation, respiration and meditation will be performed. a yoga-based exercise programme consisting of exercises will be applied for 40 minutes and 12 sessions. functional capacity before and after treatment, 6-min walk test (6mwt) and vo2 maximum and disease activity will be assessed by asdas-crp. clinical measurements bath ankylosing spondylitis functional index (basfi), bath ankylosing spondylitis metrology index (basmi), ankylosing spondylitis quality of life (asql) scale will be used. fibromyalgia symptom severity scale and widespread pain index scores will be calculated.

Eligibility criteria:
inclusion criteria: axial spondyloarthritis patients according to asas criteria having a stable health condition, having ongoing fatigue, dyspnea, decreased stamina, difficulty in activities of daily living, anxiety, or depression complaints exclusion criteria: * hemodynamically unstable, cardiac and pulmonary system unstable, with neurological, and psychological disorders patients

Keywords: axial spondyloarthritis, yoga, aerobic exercise
injectable collagenase and percutaneous needle fasciotomy for dupuytren's contracture

Conditions: Dupuytrens Contracture

Summary: comparing injectable collagenase and percutaneous needle fasciotomy for dupuytren's contracture affecting proximal interphalangeal joints. an open label, medico-independent randomized controlled trial.


Eligibility criteria:
inclusion criteria: * dc affecting pip joint with passive extension deficit (ped) more than 20 degrees * clearly defined strings exclusion criteria: * allergies to used medication * international normalised ratio more than 2.0 * pregnancy and breastfeeding * previous treatment for dc in affected finger * former inclusion in the study with another string * activity in disease at time of study * ped more than 20 degrees for metacarpophalangeal or distal interphalangeal joint in affected digit
the effect of peri-implant surgery and chair-side supportive post surgical peri-implant therapy

Conditions: Periimplantitis; Peri-implant Mucositis

Summary: peri-implantitis is defined as inflammation in the mucosa surrounding an oral implant with loss of supporting bone. the goals of peri-implantitis treatment are to resolve inflammation and to arrest the progression of disease. it is important to systematically gather information on the effect of surgical peri-implant treatment and to assess different protocols regarding chair-side maintenance of peri-implant tissue after surgery the aims of this clinical investigation are to evaluate the clinical, microbiological and radiographic outcomes of surgical treatment of peri-implantitis and to evaluate the efficacy of 2 supportive treatment protocols based on the use of titanium cyrettes or by the use of a flexible, biodegradable chitosan brush. furthermore, to evaluate the impact of this therapy on selected biochemical markers associated with chronic inflammation and bone tissue destruction.

little is known about the effect of chair-side maintenance of dental implants after peri-implantitits surgery. traditionally, the maintenance has been performed by titanium curettes to remove microbiological deposits from the submucosal area. the labrida biodegradable brush is a novel debridement device intended for use on dental implants. the concept of using a biodegradable material is related to the suggested problems with leaving remnants on the treated implant surface which would be negative from a bone regenerative aspect. the use of a flexible brush relates to the access problems when treating dental implants both related to the threads as well as due to the prosthetic supra construction hindering access for debridement with regular instruments developed for teeth. the material used in the brush will be chitosan which is a natural polysaccharide, chitosan (poly-n-acetyl glucosaminoglycan), which is a nontoxic and bioabsorbable (rek-approval 2012/791 polymer). h0: it is possible to maintain peri-implant health after surgical peri-implantitis treatment. there is no short- or long term clinical or radiographical differences between patients surgically treated for peri-implantitis maintained by the use of titanium cyrettes or with the labrida brush in chair-side supportive care

Eligibility criteria:
inclusion criteria: overt peri-implantitis presenting at least one implant with; * radiographic bone loss ≥ 2.0 mm * bleeding on probing (bop) main exclusion criteria: * radiotherapy * chemotherapy * systemic long-term corticosteroid treatment * pregnancy or nursing * anatomical abnormalities * history of previous treatment of peri-implantitis within 6 months after the screening * american society of anesthesiologists (asa) classification for assessing the fitness of patients before surgery \> 2
effectiveness of vancomycin loading therapy

Conditions: Infection

Summary: the goal of tish clinical research study is to identify that loading of vancomycin can facilitate rapid attainment of target trough serum vancomycin concentration.

the study drug * vancomycin : a glycopeptide antibiotic, is the first line agent in the treatment of methicillin resistant staphylococcus aureus study design : randomized controlled trials study drug administration * if your doctor believes you are eligible, and you agree to take part in this study, you will be randomized to two treatment groups.

Eligibility criteria:
inclusion criteria: * admission to samsung medical center micu and general wards for infectious diseases and hematology division * patients with sirs (systemic inflammatory response syndrome) * intravenous vancomycin therapy deemed necessary exclusion criteria: * age less than 20 years * age more than 75 years * current renal insufficiency defined as estimated glomerular filtration rate \< 50mg/min/1.73 m2 by mdrd equation * history of adverse events to vancomycin 5. pregnant woman