Kornimate/medical-research-clean huggingface dataset:
influence of assistive device use while performing dual task in patients with stroke

Conditions: Stroke

Summary: the primary purposes of the this three-year research proposal are to investigate the influence of assistive device use on dynamic balance and the associated attentional demands during standing and walking in patients with stroke

research has shown the effectiveness of using ambulatory assistive devices to increase standing stability of patients with stroke in clinical practice (maeda et al., 2001). however, literature has also suggested that manipulation of ambulatory assistive devices in dynamic motor tasks, such as walking, inevitably requires additional attention, even in healthy adults (wright \& kemp, 1992). given that the majority of patients with stroke suffer from balance control difficulty, which subsequently increases their attentional demands associated with maintaining balance (brown et al., 2002), it remains an important question as to whether the use of ambulatory assistive devices would take away some attentional resources that would otherwise be used for maintaining balance.

Eligibility criteria:
inclusion criteria: healthy adults * between 50 and 75 years old * having no neuromuscular or musculoskeletal disorders that would jeopardize their balance control abilities * being willing to sign an informed consent approved by the human subjects committee of the national taiwan university hospital stroke patients * between 50 and 75 years old * hemiplegic or hemiparetic as a result of a single cerebral vascular accident * medically stable with no ongoing complications * independently walking without using any assistive device for at least 10 meters, and have the exercise endurance for at least 30 minutes * having no serious hemianopsia, hemi-inattention or any obvious cognitive problems as evaluated with the mini-mental state examination * being willing to sign an informed consent approved by the human subjects committee of the national taiwan university hospital exclusion criteria: * unable to follow the order of the experimenters, and having serious comprehension and expression impairment

Keywords: hemiplegia assisstive device walking dynamic equilibrium reaction time attention dual task
hyperangulated vs macintosh blades for intubation with videolaryngoscopy in icu

Conditions: Acute Respiratory Failure; Intubation; Intubation; Difficult or Failed; Videolaryngoscopy; Intubation Complication

Summary: tracheal intubation in the intensive care unit (icu) is associated with high incidence of difficult intubation and complications. videolaryngoscopes (vls) devices have been proposed to improve airway management, and the use of vls are recommended as first-line or after a first-attempt failure using direct laryngoscopy in icu airway management algorithms. although until relatively few years ago there were doubts about whether videolaryngoscopes had advantages over direct laryngoscopy for endotracheal intubation (eti) in critically ill patients, two recent studies (device (1), intubate (2)), and a cochrane review (3) have confirmed that videolaryn should be used?, and what is the best blade? . there are two types of blades commonly used with videolaryngoscopes: the "macintosh" blade with a slight curvature, and hyperangulated blades. the "macintosh" blades have a lower angle of vision, but they have the advantage of being similar to the blades commonly used in direct laryngoscopy, making them easy to use for the person performing the eti. hyperangulated blades have a greater angle of vision, improving glottic visualization, especially in patients with an anterior glottis. however, the need to overcome this angulation could potentially hinder the passage of the endotracheal tube to the vocal cords. it is unknown if either blade has any advantage for intubating critically ill patients.

the purpose of this prospective multicenter randomized study is to compare successful intubation on the first attempt with the macintosh videolaryngoscope vs the hyperangulated videolaryngoscope during tracheal intubation in icu patients.the hypothesis of the study is that tracheal intubation using the hyperangulated videolaryngoscope will improve the frequency of successful intubation on the first attempt in icu patients requiring intubation in the intensive care unit.

Eligibility criteria:
inclusion criteria: * age 18 years or older. * admitted to an intensive care unit. * need for tracheal intubation during the stay in the icu. * the device to be used for intubation is a videolaryngoscope exclusion criteria: * pregnancy or lactation. * emergent tracheal intubation that does not allow for the randomization of the procedure. * need for tracheal intubation with a device other than the videolaryngoscope (fiberoptic bronchoscope, direct laryngoscopy, tracheostomy, etc.). * tracheal intubation performed outside the icu (emergency department, hospital ward, etc.).

Keywords: videolaryngoscopy tracheal intubation complication
comparison of treatment of recurrent hcc with repeat hepatectomy,and tace with afp conversion

Conditions: Recurrent Hepatocellular Carcinoma

Summary: the purpose of this study is to compare the treatment of recurrent hepatocellular carcinoma with repeat hepatectomy,and transcatheter arterial chemoembolization (tace) with afp conversion.

though many hcc patients have been benefited from hepatectomy treatment, still the high recurrence rate after the hepatectomy led to limited effectiveness. this is the first study in same case system on comparison of effectiveness among repeat hepatectomy, and tace with afp conversion.

Eligibility criteria:
inclusion criteria: 1. via clinical diagnosis and confirm it is early recurrent liver cancer with afp conversion, and not accept any anticancer treatment. 2. age:18-70years 3. better liver function (child-pugh，class a or b) exclusion criteria: 1. reject to attend； 2. impossible to come to our hospital for physical examination regularly. 3. cancer epitome、seed focus、lymph node or distant metastasis 4. blood clotting function hindrance; 5. serious heart、lung、kidney disease

Keywords: recurrent hepatocellular carcinoma transcatheter arterial chemoembolization afp conversion
taichi-dtx for treating long covid symptoms

Conditions: Fatigue; Dyspnea; Cognitive Impairment; Muscle Pain

Summary: the randomized controlled trial will be conducted to evaluate the effectiveness of a multi-domain tai chi digital therapy for treating the individuals suffering from the long term covid-19 syndrome (long covid).

the randomized controlled trial will be conducted to evaluate the effectiveness of a multi-domain tai chi digital therapy for treating the individuals suffering from the long term covid-19 syndrome (long covid). this intervention will comprise of traditional tai chi physical therapy with background music entraining 40 hz sound wave and respiratory control training. the multi-domain tai chi digital therapy will be delivered via a tablet or smart phone to participants for a 4-week therapeutic cycle. clinical standardized physical tests and self-scored questionnaires will be collected to understand the change in symptoms, including fatigue, dyspnea, and brain fog, as well as absenteeism.

Eligibility criteria:
inclusion criteria: 1. clinical diagnosis with sars-cov2 infection via pcr during the past 3 to 6 months 2. must be grade 2 and grade 3 assessed by the post-covid-19 functional status (pcfs) scale exclusion criteria: 1. admitted in the intensive care unit due to sars-cov2 infection or any other serve illness 2. psychiatric diseases and somatic co-morbidities 3. covid-19 infections or co-morbidities started or exacerbated during the same time

Keywords: long covid, tai chi, digital therapeutics
erector spinae plane block in cardiac surgery

Conditions: Pain, Acute

Summary: ultrasound guided bilateral erector spinae plane block will be used as adjuvant to general anaesthesia in cardiac surgery


Eligibility criteria:
inclusion criteria: * elective surgery exclusion criteria: * emergency * patient refusal * infection at or near catheter insertion
internally versus externally guided body weight-supported treadmill training (bwstt) for locomotor recovery post-stroke

Conditions: Stroke

Summary: the overriding goal of this proposal is to identify the critical physiological and biomechanical effects of bwstt for promoting improved locomotor function in persons with post-stroke hemiparesis.

in this pilot study, we tested two forms of locomotor training for gait rehabilitation in persons post-stroke: traditional locomotor training (partial body-weight support and manual assistance of therapists) vs. robotic-assisted locomotor training (partial body-weight support and robotic guidance with the lokomat). we enrolled 16 persons with chronic (\>6 months) hemiparesis post-stroke who were randomized to traditional/manual or robotic locomotor training. all individuals received 12 sessions (thrice weekly for four weeks) of training. each session involved 30 minutes of stepping. the complete study results are published.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of cerebrovascular accident * single event * unilateral hemiplegia * locomotor disability * ability to walk independently 25' on level ground (may use an assistive device \[cane or walker\]; may not use a brace) * cognitive ability to follow 3-step commands exclusion criteria: * unstable or uncontrolled blood pressure * uncontrolled seizures * severe cognitive impairment

Keywords: biomechanics stroke electromyography gait disability stroke locomotor therapy muscular weakness reflex variability stroke
efficacy and safety study of bmn 110 for morquio a syndrome patients who have limited ambulation

Conditions: Mucopolysaccharidosis IVA; Morquio A Syndrome; MPS IVA

Summary: the primary objective of this study is to evaluate the effect of 2.0 mg/kg/week bmn 110 in a patient population that has limited ambulation, in a period of up to 144 weeks.

effect is defined by the following key domains: * upper extremity function and dexterity * mobility

Eligibility criteria:
inclusion criteria: * is willing and able to provide written, signed informed consent (or their legally authorized representative) after the nature of the study has been explained and prior to performance of any research-related procedure. patients who do not meet country and local age requirements for informed consent must be willing and able to provide written assent after the nature of the study has been explained and prior to performance of any research-related procedure. * has documented clinical diagnosis of mps iva based on clinical signs and symptoms of mps iva and documented reduced fibroblast or leukocyte galns enzyme activity or genetic testing confirming diagnosis of mps iva. * is ≥ 5 years of age. * if sexually active, is willing to use an acceptable method of contraception while participating in the study. * females of childbearing potential must have a negative pregnancy test at the screening visit and be willing to have additional pregnancy tests during the study. * is willing and able to perform all study procedures as physically possible. exclusion criteria: * is able to walk farther than a specified distance as assessed by the 6mwt. * has previous hematopoietic stem cell transplant (hsct). * has received previous treatment with bmn 110. * has a known hypersensitivity to any of the components of bmn 110. * has had major surgery within 3 months prior to study entry or is planning to have a major surgery during the first 24 weeks of the study. * has used any other investigational product or investigational medical device within 30 days prior to the screening visit or requires any investigational agent prior to completion of all scheduled study assessments. * is pregnant or breastfeeding at the screening visit or planning to become pregnant (self or partner) at any time during the study. * has a concurrent disease or condition, including but not limited to symptomatic cervical spine instability or severe cardiac disease or complete paralysis due to a spinal cord injury (defined as an inability to move arms and legs), that would interfere with study participation or safety as determined by the investigator. * has any condition that, in the view of the investigator, places the patient at high risk of poor treatment compliance or of not completing the study.

Keywords: mucopolysaccharidosis iva type a mps iva type a mucopolysaccharidosis iva mps iva morquio a syndrome lysosomal storage disorder lsd n-acetylgalactosamine-6-sulfatase n-acetylgalactosamine-6-sulfate sulfatase galactose-6-sulfatase galns enzyme replacement therapy ert mor-006 cpet limited ambulation grip/ pinch
somofilcon a 1-day multifocal study - real world subjective acceptance study

Conditions: Presbyopia

Summary: the objective of the study is to evaluate the performance of somofilcon a 1 day multifocal when worn on a daily disposable wear modality over a period of up to 3 weeks.


Eligibility criteria:
inclusion criteria: * is at least 17 years of age and has full legal capacity to volunteer; * has read and signed an information consent letter; * is willing and able to follow instructions and maintain the appointment schedule; * has had a self-reported oculo-visual examination in the last two years. * currently wears multifocal soft contact lenses, and have worn multifocal contact lenses for at least one month; * presently wears lenses for minimum wear 4 days/week and 10 hours/day * participant has an anticipated ability to wear test lenses for minimum 5 days/week and 10 hours/day. * can be fit with the available test contact lens power range to achieve satisfactory vision i.e. 0.18 logmar (20/30) binocular distance acuity with the test lenses. * current refraction indicates a reading addition of +1.50 or higher * uses a digital device (computer/laptop/tablet etc.) for at least 5hrs/day * spends 10 hrs or more indoors at least 5 days/week * possesses a smartphone and is willing to download the metricwire app to receive exclusion criteria: * is presently wearing clariti 1 day multifocal lenses * has astigmatism greater than -0.75 dcyl as determined with subjective refraction * is participating in any concurrent clinical or research study; * has any known active\* ocular disease and/or infection; * has a systemic condition that in the opinion of the investigator may affect a study outcome variable; * is using any systemic or topical medications that in the opinion of the investigator may affect a study outcome variable; * has known sensitivity to fluorescein dye or products to be used in the study; * is pregnant, lactating or planning a pregnancy at the time of enrolment (by verbal confirmation at the screening visit); * is aphakic; * has undergone refractive error surgery; * is an employee of the centre for contact lens research
analysis of bacterial microbiome of endodontically infected primary and permanent teeth

Conditions: Endodontic Disease; Endodontic Inflammation

Summary: recognition of community profiles in endodontic infections may allow a better understanding of the pathogenesis of the disease and the establishment of more effective treatment protocols. therefore, the aim of the present study was to investigate bacterial diversity in endodontically infected primary and permanent teeth using 16s rrna gene sequencing and qiime 2tm (quantitative insights into microbial ecology 2) bioinformatics pipeline

endodontic infections are defined as an infection of the pulp and periapical tissues. this infection is caused by microorganisms that invade the pulp via dental caries or dental trauma. in these mixed population infections, anaerobic bacteria have been reported to be conspicuously dominant and the number of microorganisms per canal may vary. traditionally, the endodontic microbiome has been identified by culture-based (phenotype-based) techniques. inability to cultivate approximately 40-55% of bacteria in the endodontic microbiome, bias or inexperience of researchers may limit the results of cultural research. microbiome-based new generation sequencing (ngs), which was initially used in ecological studies, has been widely used in recent years to identify bacterial diversity using the 16s ribosomal rna (rrna) gene in endodontic infections microbiome, bias or inexperience of researchers may limit the results of cultural research. there are few studies investigating the endodontic microbiome in primary teeth. however, to the best of our knowledge, to date, there is no metagenomic study that investigates the endodontic microbiome of the primary and permanent teeth. it is a still question of whether there is a difference in the endodontic microbiomes during the mixed dentition period when both dentition types can be seen.

Eligibility criteria:
inclusion criteria: * have intact roots or \<1/3 of physiological root resorption * have clinical crowns that permit effective rubber dam isolation * no mobility, fistula, pus discharge, gingival swelling, periapical abscess or internal resorption. exclusion criteria: * have marginal periodontitis, a history of pharmacological treatment, antibiotics or fluoride intake within the last 2 months * a history of cancer, diabetes or immunodeficiency disorders

Keywords: endodontic disease microbiome permanent teeth primary teeth
rectal cancer shared care

Conditions: Rectal Cancer; Low Anterior Resection Syndrome

Summary: the investigators propose a multifaceted rectal cancer survivorship care program involving oncology specialists, nursing support and primary care physicians. this initiative centers on regular meetings with oncology nursing support, enhanced communication and coordination of care among clinicians including primary care physicians, and an educational platform for patients regarding the late and long-term effects of cancer. initial efforts will target rectal cancer patients specifically as they have been identified as being at high risk of having unmet needs. once we have realized measurable, successful implementation in this population, our hope is then to expand our initiative to all colon cancer patients.

rectal cancer is a life-altering diagnosis that can have long-lasting effects not only on one's physical health, but also their psychological, emotional and financial well-being. with advancements in both disease detection and therapeutic options, there is now a growing cohort of patients who have successfully completed active rectal cancer treatment and transitioned into post-treatment care. unfortunately, the post-treatment phase has its own set of challenges. lost in transition was one of the first major publications to advocate for dedicated survivorship planning, raising awareness of the needs of cancer survivors. since then, both the national comprehensive cancer network (nccn) and the american cancer society have released guidelines for survivorship care focused on prevention, surveillance, assessment, intervention, coordination of care and survivorship planning. despite these efforts to bolster survivorship care, studies have found an average of 2.88 unmet needs among cancer survivors affecting physical, financial, educational, emotional and psychology domains. the investigators propose a multifaceted rectal cancer survivorship care program involving oncology specialists, nursing support and primary care physicians. this initiative centers on regular meetings with oncology nursing support, enhanced communication and coordination of care among clinicians including primary care physicians, and an educational platform for patients regarding the late and long-term effects of cancer. initial efforts will target rectal cancer patients specifically as they have been identified as being at high risk of having unmet needs. once the investigators have realized measurable, successful implementation in this population, the hope is then to expand this initiative to all colon cancer patients.

Eligibility criteria:
inclusion criteria: * adult (\>18 years-old) * rectal cancer patients who underwent curative intent treatment between 2019-2020 (i.e. in the last 2 years), including those who underwent surgical resection (abdominoperineal resection or restorative proctectomy with or without ileostomy) and those managed non-operatively, with chemoradiotherapy will be included. exclusion criteria: * cannot be contacted by telephone * unable to read and comprehend english or french; * unable to give clear and informed consent.
the ai prognostic assessment and pathological basis research of early hcc after minimally invasive treatment

Conditions: Hepatocellular Carcinoma

Summary: the study evaluates artificial intelligence method based on multimodal magnetic resonance imaging (mri) images and clinical data in preoperative prediction of prognosis in early hepatocellular carcinoma (hcc) patients treated with minimally invasive treatment. the correlation between prognosis-related mri features and pathological features was studied through artificial intelligence method, so as to provide the interpretability of image features for predicting the prognosis of hcc patients treated with minimally invasive treatment.

the prognosis prediction of early stage hepatocellular carcinoma (hcc) after minimally invasive treatment involves clinical decision of treatment and follow-up. magnetic resonance imaging (mri) has become the main approach for monitoring and following up of hcc, however it's difficult to predict hcc prognosis before surgery. we found the following limitations among previous researches: multimodal mri using different sequences shows uncertain boundaries of hcc, which makes precise segmentation more difficult, and also leads to an additional workload for extracting high throughput radiomics features, which are limited in quantity and repeatability. regarding to prognosis aspect, the mri images, clinical data, and follow up information have not been fully exploited yet. in addition, the prognosis result obtained by radiomics workflow is difficult to be explained and applied to clinical application. therefore, we conduct a study to solve the problems mentioned above: (1) to explore an effective deep learning neural network method and a pre-training model for improving tumor segmentation accuracy. (2) to establish a method for extracting high-throughput multi-dimensional and multimodal mri radiomics features related to hcc prognosis. (3) to explore a correlation between "multimodal mri based pathological features of early stage hcc" and the results of "multimodal mri based prognosis depth network of early stage hcc after minimally invasive treatment". based on above approaches, we aim to establish "multimodal mri based prognosis model of early stage hcc after minimally invasive treatment" in different clinical application scenarios guiding to clinical decision-making. moreover, we also aim to explore the correlation between mri radiomics features and pathology, which provides theoretical foundations for the mri radiomics based pathological researches.

Eligibility criteria:
inclusion criteria: * hepatocellular carcinoma patients received minimally invasive treatment (transcatheter arterial chemoembolization, radiofrequency ablation, or combined) or hepatectomy; * patients received mri examination within 1 month before treatment; * complete post-treatment prognosis information. exclusion criteria: * local or systemic treatment before mr examination; * incomplete clinical and pathological data; * heavy image artifacts.

Keywords: precision medicine information processing lesion recognition feature extraction deep learning diagnosis model