Kornimate/medical-research-clean huggingface dataset:
mucoderm or connective tissue graft for treatment of gingival recessions

Conditions: Gingival Recession

Summary: coronally advanced flap plus connective tissue graft (ctg) is the gold standard therapy for root coverage. the bioabsorbable porcine collagen matrix (cm) has been widely used in periodontal and mucogingival surgery as a substitute for ctg and has achieved similar results. the cm has the advantage of no need of a second surgical area and availability overcoming the limitations of donor site in autograft. the aim of this study is to investigate the use of mucoderm® in root coverage procedures combined with extended coronally positioned flap (ecaf), test group (tg), in comparison to the connective tissue graft associated with the ecaf, control group (cg).


Eligibility criteria:
inclusion criteria: * cej without significant damage; * localized bilateral rt1 gingival recession ≥3 mm in the same arch exclusion criteria: * previous periodontal surgical treatment on the involved sites; * smokers * pregnants or lactating * compromised systemic health and contraindications for periodontal surgery

Keywords: clinical trial root coverage biomaterials collagen matrix coronally advanced flap
re104 safety and efficacy study in adjustment disorder in cancer and other medical illnesses

Conditions: Adjustment Disorder

Summary: the purpose of this study is to determine if treatment with a single dose of re104 for injection reduces depressive symptoms or depressive symptoms mixed with anxiety symptoms in participants with adjustment disorder due to cancer or other illnesses such as amyotrophic lateral sclerosis (als), multiple sclerosis (ms), parkinson's disease (pd) or idiopathic pulmonary fibrosis (ipf) as compared to active-placebo.


Eligibility criteria:
inclusion criteria: * has a ≥4 week history of ajd as defined by dsm-5-tr with either depressed mood, or mixed anxiety and depressed mood confirmed by clinical interview with evidence that the ajd was instigated by one of the following medical illnesses (e.g., diagnosis, management, recurrence, prognosis): cancer, als, ms, pd or ipf * is sufficiently ambulatory and capable of self care as necessary to complete study procedures * has normal cognitive function * is on stable use of antidepressants or psychotherapy, or is willing to delay use until the end of study * if female is not pregnant or planning to become pregnant. if male is not planning to make a partner pregnant * is willing and able to comply with the conditions and requirements of the study exclusion criteria: * has a significant risk of suicide * has active or medical history of bipolar disorder, schizophrenia, schizoaffective disorder, psychotic disorder and/or borderline personality disorder, or first-degree family history of psychosis or bipolar disorder * has active or a history of central nervous system malignancy * has other medically significant conditions rendering unsuitability for the study * has used or will need to use prohibited medications or therapies * has a known sensitivity or intolerance to study intervention or potential rescue medications

Keywords: cancer amyotrophic lateral sclerosis (als) multiple sclerosis (ms) parkinson&amp;#39;s disease (pd) idiopathic pulmonary fibrosis (ipf) depression anxiety psychiatric distress
detection of covid-19 (sars-cov-2) in the semen of covid+ patients (positive rt-pcr on a nasopharyngeal swab)

Conditions: COVID

Summary: the objective of this study is to look for the presence of sars-cov-2 in the semen of patients diagnosed with covid+ based on rt-pcr analysis of nasopharyngeal swabs.

this is a prospective monocentric, open-label, prospective study of male patients with cov-2-sars.

Eligibility criteria:
inclusion criteria: * male patient between the ages of 18 and 65 who has read and signed the consent form for participation in the study. * outpatient or inpatient without signs of respiratory severity, likely to be mobile * patient whose medical condition warrants screening for covid-19 by nasopharyngeal swab exclusion criteria: * patient under protective custody, guardianship or trusteeship * patient not affiliated to the french social security system * inability to provide the subject with informed information and/or written informed consent: dementia, psychosis, consciousness disorders, non-french speaking patient
the effect of distant reiki application on pain, functional status and sleep quality

Conditions: Rheumatoid Arthritis

Summary: rheumatoid arthritis (ra) is a chronic, multisystemic, progressive autoimmune disease characterized by joint destruction in synovial tissue, causing joint swelling, pain and morning stiffness. it is estimated to affect 0.1%-2% of the world's adult population and more women than men. ra limits individuals' work, social, and home lives and functional capacities. patients commonly experience pain and accompanying sleep problems. interventions for these problems and symptom management are important. in this regard, this study was planned to examine the effect of distant reiki application on pain, functional status and sleep quality in rheumatoid arthritis patients.


Eligibility criteria:
inclusion criteria: * being over 18 years old, * not having a communication problem, * receiving outpatient treatment from the clinic where the research was conducted, * to have the physical and cognitive competence to answer the data collection forms, * not having received body-mind therapy (yoga, reiki, meditation, etc.) in the last six months, exclusion criteria: * individuals who have done reiki therapy before * being under 18 years old, * hearing and speaking problems that prevent communication, * participating in yoga, reiki, meditation practices in the last 6 months, * individuals with cognitive and severe psychiatric problems who cannot answer the survey questions
us-guided percutaneous electrolysis (epe®) in plantar fasciosis

Conditions: Plantar Heel Pain, Plantar Fasciosis

Summary: scientific evidence of conservative management of individuals with plantar fasciosis is sometimes conflicting. there is evidence that regular exercise programs are effective for this pain condition. the inclusion of other therapeutic modalities is still controversial. some authors have suggested that the use of us-guided percutaneous electrolysis (epe®) maybe useful for the management of chronic tendinopathies; however, no study has investigated the potential placebo effect of this intervention. the objective of this randomized clinical trial is to determine the effectiveness of us-guided percutaneous electrolysis (epe®) versus sham us-guided percutaneous electrolysis for the management of patients with plantar fasciosis for pain, function, and disability.


Eligibility criteria:
inclusion criteria: * insidious onset of sharp pain under the plantar heel surface upon weight bearing after a period of non-weight bearing; * plantar heel pain which increases in the morning with the first steps after waking up; * symptoms decreasing with slight levels of activity, such as walking. exclusion criteria: * prior surgery in the lower extremity; * diagnosis of fibromyalgia syndrome; * previous physical therapy interventions for the foot region in the previous 6 months * lidocaine or other injections in the plantar fascia for the management of pain in the previous 6 months
safety and efficacy of intradermal injections of newfill versus eutrophill in the treatment of facial lipoatrophy in hiv-infected patients anrs 132 smile

Conditions: HIV-Associated Lipodystrophy Syndrome

Summary: treatment of facial lipoatrophy with dermal injections polylactic acid (newfill tm) is a safe procedure and has been now widely used with a good efficacy. however, this therapy is not effective in all treated patients and the benefit of the injections may decrease with time necessitating re-injections several months after the first sets of injections. in this study we would like to compare the efficacy and safety of eutrophill(polyacrylamid gel), a resorbable filler compound versus newfill in a comparative, randomised, multicenter trial. primary endpoint will be the self-perception by the patient with a visual analogue scale (vas index). secondary endpoints are a quality of life questionnaire (mos-hiv), the a-nbc questionnaire (perception by the patient and by the doctor of the severity of the lipoatrophy), the measure of the dermal thickness and cheek skin fold as assessed by the skinfold caliper, the ordering of digital photographs and the evaluation of the dermal thickness by ct scan.

the aim of the study is to compare the efficacy and safety of eutrophill (polyacrylamid gel), a resorbable filler compound versus newfill( polylactic acid) in a comparative, randomised, multicenter trial and patient-blinded study, in the treatment of facial lipoatrophy in hiv-infected patients, one year after the first injection (week 48). the efficacy will be assessed by measuring the median self-perception index of the patients with a visual analogue scale (vas index).the study will compare between treatments, at week 48, week 72 and week 96 versus baseline :the median increase of the vas index, the rate of treatment failure, the scores of 2 patients-questionnaires (a-nbc and mos-hiv),the ordering of digital photographs,the median increase of the facial dermal thickness of the cheek and the dermal skin fold as assessed by a skinfold caliper. the study will compare at week 48 and week 96 versus baseline: the median increase of dermal thickness as assessed by ct scan of the face. safety will be assessed by the frequency and nature of immediate and delayed side effects.

Eligibility criteria:
inclusion criteria: * 18 years of age and older * confirmed laboratory diagnosis of hiv infection * facial lipoatrophy * stable antiretroviral treatment or no treatment for at least 3 months * written informed consent exclusion criteria: * history of surgical or cosmetic intervention for facial lipoatrophy * no history of antiretroviral therapy * current opportunistic infection * currently stavudine containing antiretroviral regimen * cd4 cell count under 200per µl, plasma hiv rna above 10000 copies per ml under antiretroviral therapy * platelets under 50000 per µl and or abnormal coagulation tests * pregnancy * major or concomitant illness

Keywords: hiv-associated lipodystrophy syndrome polylactic acid polyacrylamide gels
a comprehensive community approach for diabetes prevention and care for a vulnerable population in galveston

Conditions: Diabetes Mellitus, Type 2

Summary: to improve diabetes self-management outcomes, patients with type 2 diabetes (n=150 - aged 13-84) recruited from st. vincent clinic (svc) and teen health center inc., clinics will be randomized using block randomization to receive standard of care or the integrated model. patients in the intervention arm will be assessed for social and physical needs before being enrolled in a year-long education program (idsmes). enrollees will receive dietary counseling, physical and occupational therapy, in addition to other mental, financial and social benefits counseling. the investigators will compare the intervention outcomes.


Eligibility criteria:
inclusion criteria: 1. patients aged 13-84, and 2. patients diagnosed with type 2 diabetes, and 3. patients have a bmi equal to or \>25 (23, if asians), and 4. hemoglobin a1c value equal to or \>7% exclusion criteria: 1. ages \ 84 2. pregnancy. if a subject becomes pregnant, they will advised to discontinue the study. 3. previous diagnosis of type 1 diabetes 4. inability to participate for 12-month duration (e.g., disorders that might compromise survival, planning to relocate outside the geographical coverage of university of texas medical branch (utmb) clinics 5. other medical condition or medication administration deemed exclusionary by the study investigators 6. prisoners
effect of cefazolin and normal saline irrigation on surgical site infections (ssis)

Conditions: Surgical Site Infections

Summary: this study conducted to assess the effects of normal saline or cefazolin irrigation on the incidence of ssis. hypothesis: normal saline or cefazolin irrigation decreases the incidence of ssis.

all pregnant women who underwent cesarean after 6 hours passed their rupture of membrane and attended to shariati hospital of bandarabbass were eligible for our study.

Eligibility criteria:
inclusion criteria: * pregnant women * 6 hours passed their rupture of membrane * needed to undergo cesarean exclusion criteria: * allergy to penicillin * allergy to cefazolin * history of immunosuppressive drug use * gestational diabetes mellitus * preeclampsia

Keywords: surgical wound infection cefazolin cesarean section
relationship between erythropoietin administration and stress responses in trauma patients

Conditions: Multiple Trauma

Summary: the purpose of this study is to determine whether erythropoietin decrease stress responses and inflammation in trauma patient.

transfusion of blood products has many disadvantages. erythropoietin is used to increase red blood cells production and decrease such disadvantages.in some studies anti inflammatory effects is shown for erythropoietin. one of the most problems in the intensive care unit is stress response. we are going to evaluate effects of erythropoietin on oxidative stress and inflammation in trauma patient in intensive care unit.

Eligibility criteria:
inclusion criteria: * all multiple trauma patients\>16 years with informed consent exclusion criteria: * hypertension * allergy * erythroid leukemia * pregnancy and breast feeding * pre operative patient * severe cardiovascular and cerebrovascular diseases * thromboembolic disorders

Keywords: multiple trauma
a study to learn about the study medicine called pf-07905428 in healthy participants and participants with acne vulgaris

Conditions: Acne Vulgaris

Summary: the purpose of this clinical trial is to learn about the safety and effects of the study medicine (called pf-07905428) for the potential treatment of acne vulgaris. this study is seeking participants who: * are male or female between the ages of 18 and 40 * are generally healthy * are diagnosed with moderate to severe acne vulgaris (cohort 4 only) the study medicine will be applied every day on the participant's face and/or back for 14 days (cohorts 1 and 2) or for 28 days (cohort 3 and 4). the investigators will compare the experiences of people receiving the study medicine to those of the people who do not. this will help the investigators determine if the study medicine is safe and effective. participants will take part in this study for approximately 2 months. during this time, they will have 17 study visits (cohorts 1 and 2) or 31 study visits (cohorts 3 and 4) at the study clinic. the study team will also call participants once at the end of the study over the phone.


Eligibility criteria:
inclusion criteria: * participants who are overtly healthy as determined by medical evaluation. * only for participants who are enrolling with acne vulgaris: diagnosis of acne vulgaris for 3 months or greater * for participants enrolling in cohort 1-3 with acne vulgaris (optional): mild to moderate facial acne vulgaris * for participants enrolling in cohort 4 with acne vulgaris: moderate to severe facial acne vulgaris exclusion criteria: * participants with very severe acne * participants with autoinflammatory syndromes * evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurological, or allergic disease * history of human immunodeficiency virus (hiv) infection, hepatitis b, or hepatitis c. * participants with clinically significant laboratory abnormalities
multi center observation of sentinel skin graft for detecting acute rejection after renal transplantation

Conditions: Kidney Transplant Rejection; Skin Graft

Summary: the purpose of this study was to explore the accuracy of sentinel skin grafts from the same donor source in diagnosing renal allograft rejection, and to provide new ideas and options for the later clinical diagnosis of renal allograft rejection. further, try to provide timing guidance for early immunization intervention.


Eligibility criteria:
inclusion criteria: 1. patients with end-stage renal disease undergoing renal transplantation; 2. 18-60 years old; 3. postoperative follow-up points are complete (visit the hospital every week in the first month after surgery, every two weeks in 2-3 months, every four to six months, and every three months in 7-12 months. follow up at any time when skin rejection is observed. the follow-up time may be adjusted when the condition changes); 4. the participants had good compliance, volunteered to participate in the test and signed the informed consent form. exclusion criteria: 1. untreated or disseminated malignant tumor; 2. active period of infectious diseases; 3. serious cardiovascular disease occurred recently; 4. combined with other important organ failure; 5. history of mental illness or cognitive impairment;
routine or on-demand fentanyl in colonoscopy

Conditions: Pain

Summary: colonoscopy may be an unpleasant procedure. sedation and/or analgesics is therefore routinely administered in most countries. in norway, however, routine sedation is rare, and medication is normally given on demand, that is, if necessary during the procedure. the investigators want to evaluate whether the effect of fentanyl, a synthetic opioid with fast onset of action, is better given before the procedure than during the procedure.


Eligibility criteria:
inclusion criteria: * age 18-75 * referred for out-patient colonoscopy exclusion criteria: * asa-score 3 or higher * same day upper endoscopy * pregnancy * pacemaker * patient require medication before colonoscopy * previous resection of colon or rectum * significant psychiatric morbidity * oxygen saturation \< 95% without supplementary oxygen * contra indications to fentanyl * inability to sign inform consent * inability to understand information about the trial

Keywords: colonoscopy pain
evaluative conditioning: a brief cognitive intervention aimed to modify addiction behaviour of alcohol-dependent patients

Conditions: Cognitive Intervention to Modify Addiction Behaviour of Alcohol-dependent Patients

Summary: evaluative conditioning: a brief cognitive intervention aimed to modify addiction behaviour of alcohol-dependent patients


Eligibility criteria:
inclusion criteria: * participants in this study will be patients: * with an alcohol use disorder according to dsm 5 * follow-up at the laborit hospital center * aged between 18 and 70 years with informed consent after receiving written information * engaged in a process to reduce alcohol consumption * with a score of moca\> 20 * whose mother tongue is french * patients benefiting from social security or benefiting from it through a third party in accordance with the french law on research involving the human person. exclusion criteria: * - patient with less than 6 heavy drinking days in the month * patient with schizophrenia * patient with bipolar disorder type 1 * patient with korsakoff syndrome or degenerative neurological disorder * patient with hearing impairment, uncorrected visual impairment * patient under curatorship or guardianship * patient with addiction to another substance other than tobacco * patient already enrolled in another interventional study * pregnant or nursing woman * patient with difficulties of expression or comprehension in french * patients in emergency situations or unable to give their consent. output criteria: * patient who has manifested verbally or in writing, the desire to leave the study in progress. * patient who will be hospitalized during the study for a problem related to his addiction.

Keywords: evaluative conditionning, addiction, alcohol, patients
docetaxel, irinotecan, and carboplatin in extensive stage non-small cell lung cancer

Conditions: Non-small Cell Lung Cancer; Extensive Stage Unresectable

Summary: primary objective: to determine the maximum tolerated dose of docetaxel when given with irinotecan and carboplatin for the treatment of inoperable lung cancer. secondary objective: to evaluate the dose-related toxicities of this triple regimen in patients with inoperable lung cancer.

a phase i/ii dose escalating study to determine the maximum tolerated dose of docetaxel when given with irinotecan and carboplatin for the treatment of inoperable lung cancer.

Eligibility criteria:
inclusion criteria: * 18 years or older unresectable lung cancer measurable or evaluable lesions karnofsky ps greater than or equal to 60% exclusion criteria: * untreated cns metastases

Keywords: non-small cell lung cancer
precision preoperative embolization of pelvic tumors to improve surgical outcomes

Conditions: Embolization; Pelvic Tumor

Summary: the main purpose of this study is to assess the efficacy of precision preoperative embolization in decreasing operative blood loss, reducing surgical complications in pelvic tumor surgery. furthermore the study aims at describing the vascularity in a series of pelvic tumors, and to correlate this with perioperative blood loss.

the main purpose of this study is to assess the efficacy of precision preoperative embolization in decreasing operative blood loss, reducing surgical complications in pelvic tumor surgery，which including poor wound healing，nerve injury，and pelvic organs dysfunction. furthermore the study aims at describing the vascularity in a series of pelvic tumors,which contains four grade：poor，moderate，rich and abundant and to correlate this with perioperative blood loss.

Eligibility criteria:
inclusion criteria: * primary or metastatic pelvic tumor * confirmed by contrast-enhanced magnetic resonance imaging (mri) or computed tomography (ct) of the pelvic * planned surgical resection exclusion criteria: * contrast medium allergy * uncontrolled or concurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
role of femoral vein wall thickness and inflammatory markers in patients with behcet disease

Conditions: Behçet

Summary: evaluation of femoral vein wall thickness and inflammatory indices in patients with behcet disease and assessment of their relation to the disease activity and related some clinical manifestations


Eligibility criteria:
inclusion criteria: * patients fulfill the international criteria for behcet's disease (icbd) * age above 18 years old * patients cooperative and can answer questions * patients who are able and willing to give informed consent exclusion criteria: * other rheumatological and vascular diseases * patients with abnormal hepatic or renal function tests , hyperlipidemia and impaired coagulation tests * patients with hypertension , diabetes mellitus , malignant and active infectious diseases * patients who are using aspirin and other platelet active drygs during the previous 6 months * patients who are not able and willing to give written consent