Kornimate/medical-research-clean huggingface dataset:
diosmin versus cabergoline for prevention of ovarian hyperstimulation syndrome

Conditions: Infertility

Summary: the purpose of this study is to compare the effect of oral diosmin to oral cabergoline in the prevention of ovarian hyperstimulation syndrome (ohss) in high-risk women underwent intracytoplasmic sperm injection (icsi).

two hundred women at risk of ovarian hyperstimulation syndrome during icsi cycles will be randomly scheduled into two equal groups. in group a, (diosmin group), 2 tab / 8 hs diosmin ( 500mg) will be given at day of hcg injection and for 2 weeks ; while in group b (cabergoline group), 1 tab/day cabergoline( 0.5 mg) will be given at day of hcg injection and for eight days.

Eligibility criteria:
inclusion criteria: infertile women undergoing intracytoplasmic sperm injection or polycystic ovarin syndrome (pco) with one of the following: 1. presence of more than 20 follicles by ultrasound 2. e2 more than 3000 pg/ml 3. retrieval of more than 15 follicles exclusion criteria: * none

Keywords: infertility icsi ohss diosmin cabergoline
safety and feasibility of the infinity catheter for radial access

Conditions: Brain Tumor; Stroke, Acute; Brain Aneurysm; Intracranial Arteriovenous Malformations; Carotid Stenosis; Cavernous Sinus Thrombosis

Summary: the main objective of this single arm study is to evaluate the safety and feasibility of the axs infinity ls (stryker, freemont, ca, usa) and axs infinity ls plus (stryker, freemont, ca, usa) catheters during the transradial approach through a secondary use of the data collected during neurointerventional procedures. this includes evaluating the conversion rates to a transfemoral approach. a secondary aim of the study is to assess the radial artery occlusion rates post procedure.

patients who are undergoing endovascular intervention will be enrolled into the study. consent will be obtained for the procedure and for the use of their prospectively collected clinical data. as the metrics analyzed in this study are already normally collected, this study can be considered as a secondary use of the data. the procedure will be done using standard criteria as per operator preference. all interventional cases at the study institution undergo a "radial first" approach, meaning that the access site of choice is the radial artery. the investigators will measure the radial artery size to ensure that the artery is greater than 2.4 mm in order to use the infinity catheter (8fr). if the artery does not meet the size criteria, only a 6fr sheath will be used, and the data recorded during the procedure will not be utilized for analysis in this study. the preoperative and postoperative care will be the same for all the patients. no tests will be done outside of standard of care.

Eligibility criteria:
inclusion criteria: * age group 18 years and above. * patients undergoing neuro-embolization using large bore catheters exclusion criteria: * patients with radial artery diameter less than 2.4 mm measured with ultrasound * age\<18 * patients who have previous surgeries at either approach site which precludes the use of one of the approach sites * patients who has poor collateral circulation, raynaud's phenomenon, radial loop, brachial or subclavian stenosis, aberrant origin of the subclavian artery * pregnant patients

Keywords: neuro-embolization
multimodal drug infiltration in total knee arthroplasty: is posterior capsular infiltration worth the risk?

Conditions: Osteoarthritis, Knee

Summary: multimodal local anesthetic infiltration (lai) provides effective pain control in patients undergoing total knee arthroplasty (tka). some surgeons avoid posterior capsular infiltration (pci) for fear of damaging posterior neurovascular structures. data are limited on the added benefits of pci using different combinations of local anesthetic agents. therefore, the investigator wanted to know the effectiveness of pain control in lai with and without pci. half of participants received lai with pci, while the other half received lai without pci during total knee arthroplasty.

analgesic agents were bupivacaine, morphine, ketorolac and epinephrine. all patients received spinal anesthesia and patient controlled analgesia (pca) for 24 hours post surgery. the surgical technique and postoperative medication protocols were identical in both groups. the visual analogue scale (vas) for pain during activity and at rest, and morphine consumption were recorded at 6, 12, 18 and 24 hours postoperatively. lai-related side effects, blood loss, length of hospital stay, and vas for satisfaction were monitored. the reviewer was blinded to treatment groups.

Eligibility criteria:
inclusion criteria: * primary oa of the knee, aged less than 80 years old, and able to understand and comply with the study procedures. exclusion criteria: * previous drug dependency * inability to undergo a spinal block * allergy to study drugs * renal insufficiency * abnormal liver function * history of stroke * history of coronary artery disease

Keywords: local anesthetic infiltration posterior capsular infiltration multimodal anesthesia knee arthroplasty pain control osteoarthritis, knee
effectiveness of an interactive educational website for improving the quality of mental health care for people with schizophrenia

Conditions: Schizophrenia

Summary: this study will evaluate the effectiveness of an interactive educational website in enhancing discussions about treatment issues and improving the quality of care for people with schizophrenia.

schizophrenia is a disabling mental disorder that causes hallucinations and delusions in those affected by it. research has proven that certain treatment methods are more effective in treating schizophrenia than others. however, not everyone with schizophrenia responds to treatment in the same way, and not all physicians use the same treatment methods. educating individuals with schizophrenia about all treatments available instead of only the treatments they are receiving may improve the quality of care and lead to better correlation between treatment and quality standards. this study will evaluate the effectiveness of an interactive educational website in enhancing discussions about treatment issues and improving the congruence between expected quality of treatment and treatment received among people with schizophrenia. participants in this open label study will be randomly assigned to either use the interactive website or read written materials and watch a video. all three sources will contain information about evidence-based treatment recommendations. both groups will complete a brief interview before performing their assigned tasks. upon completion of the interview, participants in the written materials/video group will be given the reading material and will watch a 20-minute video. participants in the web-user group will sit with a laptop computer, answer questions about themselves and their treatment, receive feedback on care that may be inconsistent with current recommendations, and receive suggestions on how to discuss this with their physicians. participants in clinical settings will be asked to allow their next clinician visit to be audiotaped to assess outcomes. a phone interview will be conducted with all participants 2 months following the intervention to assess treatment satisfaction and other outcomes. medical records will be reviewed to collect treatment information 6 months before and after the intervention.

Eligibility criteria:
inclusion criteria: * diagnosis of schizophrenia * able to read and write english * scheduled to see a participating clinician at one of the study sites exclusion criteria: * n/a

Keywords: patient participation patient education consumer involvement
a research study looking into blood levels of nnc0174-0833 in people with normal and impaired kidney function

Conditions: Overweight; Obesity

Summary: the study looks at the blood levels of a new study medicine in people with normal and impaired kidney function. participants will get the study medicine called nnc0174-0833. this is an experimental medicine and has not been approved by the us fda. it is being developed as a new medicine for weight management. participants will get 1 injection of the study medicine by a study nurse at the clinic. the injection will be with a needle in a skin fold in the stomach area. the study will last for about 9 weeks. participants will have about 7 visits with the study staff or the doctor. at the visits, participants will have clinical checks done and blood samples taken. participants will be collecting their urine several times during the study. participants will be asked about their health, medical history and habits. people who are already in another research study cannot take part. only women who are not able to become pregnant can take part in the study. only men who do not plan to father a child during the study or 6 weeks following the dose administration can take part in the study.


Eligibility criteria:
inclusion criteria: * male or female of non-childbearing potential, aged 18-80 years (both inclusive) at the time of signing informed consent. * meeting the pre-defined gfr criteria using estimated gfr (egfr) based on serum creatinine for any of the renal function groups: * for subjects with normal renal function: egfr of equal to or above 90 ml/min * for patients with mild renal impairment: egfr of 60-89 ml/min * for patients with moderate renal impairment: egfr of 30-59 ml/min * for patients with severe renal impairment: egfr of \<30 ml/min not requiring dialysis exclusion criteria: * any disorder, which in the investigator's opinion might jeopardise subject's safety or compliance with the protocol. * use of prescription or non-prescription drugs, or non-routine vitamins, which at the investigators judgement may affect subject safety or the results of the trial.
the association between autoimmune or inflammation and thyroid disease

Conditions: THYROTOXICOSIS

Summary: this study aims to evaluate the effects of thyroid functions on energy homeostasis and inflammation.

the subjects were enrolled for evaluation of thyroid functions. the associations between thyroid function and energy homeostasis and inflammation will be assessed.

Eligibility criteria:
inclusion criteria: * subjects visits outpatient department due to a suspicion of thyroid disease exclusion criteria: * psychological disorders, severe inflammatory or infection diseases.
pilot randomized controlled trial (rct): remote sbirt vs. in-person sbirt

Conditions: Pregnancy; Substance Use; Depression; Anxiety

Summary: specific aim 1: conduct a pilot, small-scale randomized controlled trial to examine feasibility and preliminary efficacy of ltw, compared to tau. outcomes related to feasibility include percentage of eligible patients recruited, study attrition, study retention, and mental health and substance use treatment appointment attendance. outcomes related to preliminary efficacy will include participation in screening, referral and treatment at baseline, compared to tau. specific aim 2: conduct a randomized controlled trial to examine the effectiveness of ltw, compared to tau. outcomes related to effectiveness include screening, screening positive, referred to and attendance to treatment at baseline, compared to tau.

participants: 450 adult, pregnant or postpartum women intervention: listening to women is a mobile phone-based program designed to enhance delivery of screening, brief intervention, and referral to treatment (sbirt), an evidence-based approach for mental health and substance use screening and treatment for perinatal women. this program was created as a result of key informant interviews with obstetric providers and pregnant and postpartum women with opioid use disorders. the program utilizes mobile phone text message-based screenings with immediate automated feedback, paired with remote care coordination and, if appropriate, home-based telemedicine mental health and substance use disorder treatment services. design: specific aim 1: a two arm pilot rct (n=35) with 2:1 allocation will examine feasibility and preliminary efficacy of ltw, compared to tau. specific aim 2: a rct (n=415) with 1:1 allocation will examine effectiveness of ltw, compared to tau. this study is part of the heal initiative (https://heal.nih.gov/).

Eligibility criteria:
inclusion criteria: 1) age 18-41; 2) currently pregnant or postpartum; 3) if pregnant, receiving prenatal care; 4) english fluency; 5) owner of a cell phone with short message service (sms) text-message based capability; 6) access to wireless fidelity (wifi) and a device to allow audio and video teleconferencing; 7) able to provide informed consent. exclusion criteria: none

Keywords: pregnancy depression substance use anxiety
sentinel lymph node mapping with different injection sites of icg in endometrium cancer

Conditions: Endometrial Cancer

Summary: the primary goal of this prospective study is to define the efficacy of the sentinel lymph node biopsy (slnb) procedure by comparing different method performed in patients with endometrial cancer. the aim of this study is to investigate whether the detection rate of sentinel lymph node (sln) with two different injection sites may be increased compared to the standard use with single site (cervix) injection in endometrial cancer.

the primary treatment for endometrial cancer involves total hysterectomy and bilateral salpingo-oophorectomy, with adjuvant radiotherapy and/or chemotherapy reserved for patients with advanced disease or who have risk factors for relapse. the tumor is confined to the uterus in 85% of endometrial cancers. hence, it's controversial to perform systematic lymphadenectomy to all patients. the primary purpose of the present study is the to investigate the feasibility of sentinel lymph node determination in endometrial cancer patients operated via conventional laparoscopy. to determine sentinel lymph nodes cervical indocyanine green will be injected prior to the surgery. during the surgery using fluorescent imaging systems sentinel lymph nodes will be removed and examined by frozen section. afterwards, systematic pelvic lymphadenectomy will be performed if sentinel lymph node is positive.

Eligibility criteria:
inclusion criteria: * • 1.age \>18 and \<80 years old * 2. the pathological diagnosis was epithelial ovarian cancer * 3.survival time is expected to exceed 3 months * 4.signed consent form exclusion criteria: * 1. patients with myocardial infarction or stroke, or unstable angina pectoris or decompensated heart function * 2.patients with a history of exhaustion or deep vein thrombosis; * 3. liver insufficiency (transaminase \>2.5 times the upper limit of the standard); * 4. renal insufficiency (serum muscle liver \>2 times the standard upper limit); * 5. pregnancy and perinatal patients; * 6. history of major organ transplantation and immune disease; * 7. psychiatric condition or language barriers * 8. alcohol or drug abuser (current or previous) * 9. unable or unwilling to sign informed consent or comply with study requirements; * 10. patients with other malignant tumors.
isocyanate antigens and t cells that cause asthma

Conditions: Asthma; Lung Diseases

Summary: to investigate whether isocyanate-induced asthma is dependent on isocyanate antigen-driven t-cell mediated, airway inflammation.

background: isocyanates are a group of highly reactive widely used low-molecular weight chemicals, and are the most commonly reported cause of occupation asthma in developed countries. yet, the mechanisms by which isocyanates cause asthma are not well defined. design narrative: the study investigates isocyanate antigen-driven t-cell responses in vitro-, following in vivo exposure using patient samples acquired through collaboration with ongoing field epidemiological and clinical studies. the study compares isocyanate antigen-reactive t-cells from primary exposure sites (skin/lung) with those from blood, to evaluate potential routes of sensitization and identify diagnostic indicators of isocyanate sensitivity/susceptibility. specifically, the study : generates and characterizes hexamethylene diisocyanate (hdi) antigens including isocyanate metabolites, and isocyanate conjugated t normal human and foreign proteins; evaluates the t-cell antigenicity of the hdi antigens, based on blood and lung lymphocyte proliferation, cytokine production, and phenotype in order to identify the molecular form of hdi that initiates airway cytokine production in asthma patients; establishes t-cell lines from the skin, lung and peripheral blood of hdi asthma patients and characterizes the phenotype, antigen specificity, cytokine production and tcr expression of isocyanate responsive t-cells in these different compartments; compares isocyanate responsive of t-cells found in the skin, lung and blood and correlates with clinical sensitivity to determine characteristics associated with exposure and sensitization leading to clinical asthma. the study was renewed in fy 2002 to extend follow-up and analysis through march 2007.

Eligibility criteria:
no eligibility criteria
fluoxetine vs aripiprazole comparative trial (fact)

Conditions: Attenuated Psychosis Syndrome

Summary: we are conducting a randomized, 24-week, double-blind study, comparing fluoxetine with aripiprazole in 48 patients with attenuated positive symptoms at a level of at least moderate severity.

to compare fluoxetine and aripiprazole on all-cause discontinuation/need to add another psychiatric medication, symptomatic improvement, and adverse effects

Eligibility criteria:
inclusion criteria: * consent obtained from patients and their parents (assent for patients under 18); * age 12-25 years (inclusive); * english-speaking; * at least one positive (scale a) sops score of 3-5, i.e., moderate, moderately severe or severe. exclusion criteria: * lifetime diagnosis of an axis i psychotic disorder, including: schizophreniform disorder, schizophrenia, schizoaffective disorder, bipolar disorder, or major depression with psychotic features; * current psychosis (any positive symptom sops score of 6, i.e., extreme); * current diagnosis of major depressive disorder, single episode or recurrent, severe without psychotic features; * current stimulant treatment; * history of neurological, neuroendocrine or other medical condition known to affect the brain; * any significant medical condition that contra-indicates treatment with either aripiprazole or fluoxetine; * past or current substance dependence; sunstance abuse within the last 4 weeks; * iq \< 70.
positive changes in quality of life of older cancer patients and their caregivers

Conditions: Psychosocial Effects of Cancer and Its Treatment; Unspecified Adult Solid Tumor, Protocol Specific

Summary: rationale: gathering information about the positive changes in quality of life of older patients with cancer and their care givers may help doctors learn more about the disease and plan better treatment. purpose: this research study is looking at positive changes in the quality of life of older cancer patients and their caregivers.

objectives: primary * to use prior data from an existing registry (quality of life survey registry for persons with cancer and family caregivers protocol case-8z05) and to expand upon these data by adding measures that capture the particularly salient concepts of the patient/caregiver dyadic relationship and posttraumatic growth. * to identify rates and psychosocial correlates of posttraumatic growth among older adult cancer patient/spouse or partner dyads. outline: patients and their caregivers complete three questionnaires that will take approximately 20 minutes either by mail or telephone. the questionnaires comprise of demographic and psychosocial correlates of posttraumatic growth including age, ethnicity, socioeconomic status, education, anxiety, relationship quality, coping style, social support, and cultural beliefs about caring for elders.

Eligibility criteria:
disease characteristics: * patient must meet the following criteria: * confirmed cancer of any type * currently receiving medical care at the ireland cancer center at university hospitals of cleveland * must have enrolled and participated in case-8z05 * identified available family caregiver of a patient diagnosed with stage iii or iv cancer patient characteristics: * patients must meet the following criteria: * ecog performance status 0-3 * cognitively competent to be interviewed * able to speak and comprehend english * caregivers must be able to speak and comprehend english prior concurrent therapy: * see disease characteristics

Keywords: psychosocial effects of cancer and its treatment unspecified adult solid tumor, protocol specific
congestive heart failure weight study

Conditions: Congestive Heart Failure

Summary: early morning weights to monitor chf patient's fluid status is common practice but there is a lack of evidence that this is the best practice. the purpose of this study is to determine if there is a difference in net weight gain or loss for hospitalized patients with chf who are weighed in the evening instead of early morning.

this is a quasi-experimental pilot study with prospective cohort design. study subjects will be weighed in the early morning and then again in the evening for a minimum of three days. analysis will be accomplished on data by analysis within-subjects data utilizing the paired t test. other data to be collected includes dates of hospitalization, demographics, dose and timing of medications, lab results and documentation of comorbid conditions.

Eligibility criteria:
inclusion criteria: * 18-85 years old * admitted to hospital with a primary diagnosis of heart failure or fluid overload * ambulatory with a medical order to be out of bed * able to stand on a scale * have no problems with balance exclusion criteria: * patients with a primary diagnosis other than heart failure or fluid overload * patients diagnosed with renal failure * non-english speaking * unable to follow directions or consent due to cognitive impairment * medical order for bed rest * involved in another study

Keywords: chf congestive heart failure