Kornimate/medical-research-clean huggingface dataset:
long-term outcome of punctate inner choroidopathy or multifocal choroiditis with active choroidal neovascularization managed with anti-vascular endothelial growth factor

Conditions: Choroidal Neovascularization; Punctate Inner Choroidopathy

Summary: to evaluate the long-term outcome of active choroidal neovascularization (cnv) in punctate inner choroidopathy (pic) or multifocal choroiditis (mfc) after anti-vascular endothelial factor treatment.

to evaluate the long-term outcome of active choroidal neovascularization (cnv) in punctate inner choroidopathy (pic) or multifocal choroiditis (mfc) after anti-vascular endothelial factor treatment. the age, sex, best corrected visual acuity (bcva) in snellen chart, and refractive status for each patient were recorded. all patients had thorough clinical examinations, including slit lamp biomicroscopy, indirect ophthalmoloscopy, and spectral domain optical coherence tomography during each visit. fundus photography, fluorescein angiography, and indocyanine angiography were performed on all patients. oct angiography was performed.

Eligibility criteria:
inclusion criteria: 1. patients were punctate inner choroidopathy or multifocal choroiditis with active choroidal neovascularization. 2. follow up over 4 years. exclusion criteria: 1. patients were not punctate inner choroidopathy or multifocal choroiditis with active choroidal neovascularization 2. patients were punctate inner choroidopathy or multifocal choroiditis with active choroidal neovascularization but loss follow over 1 year.

Keywords: punctate inner choroidopathy multifocal choroidits choroidal neovascularization anti-vegf long-term outcome
improving glycemic control on gms: a quality improvement study

Conditions: Diabetes Mellitus

Summary: this study will examine whether new processes and technologies for monitoring diabetic patients' insulin levels improves patient care at brigham and women's hospital.

this study will examine whether new processed and technologies for monitoring diabetic patients' insulin levels improves patient care. patients at brigham and women's hospital (bwh), staying on the general medicine service, who have type 2 diabetes and who are not on iv insulin can participate in this study. physicians and nurses will be taught new rules to care for diabetic patients, while in the hospital. also, the bwh computer system will be updated to include these new rules for administering insulin. patients who participate in the study will be randomly placed into one of two groups: one group that will be cared for by physicians and nurses who have learned these new rules for administering insulin; or the second group, who will receive diabetes care at bwh before the new rules were adopted. the study will last approximately 1 year.

Eligibility criteria:
inclusion criteria: * subjects will include all type 2 diabetic patients on the general medicine service (gms) of brigham and women's hospital (bwh) who do not have an indication for iv insulin. exclusion criteria: * type 2 diabetic patients on the general medicine service (gms) of brigham and women's hospital (bwh) who have an indication for iv insulin.

Keywords: diabetes mellitus outcome assessment (healthcare) inpatients hospital information systems education
periodontally accelerated osteogenic orthodontics with bmp2

Conditions: Malocclusion

Summary: rhbmp-2 has the potential to function as a regenerative material in periodontally accelerated osteogenic orthodontics (paoo). this study aimed to assess the effects of paoo with bmp-2 on outcomes such as treatment period, bone density, healing and pain.

subjects were randomly assigned into each of the following experimental groups; c+bmp: corticotomy with 0.5 μg/ml rhbmp-2 and c: corticotomy only. clinical parameters included recording the duration of treatment period, visual analogue scale (vas) scores and early healing index (ehi) scores. the evaluation of bone density was performed at baseline, 3 months and 6 months by using rvg.

Eligibility criteria:
inclusion criteria: * 30 subjects with moderate crowding of lower incisors based upon little's index and willing to undergo undergoing orthodontic treatment with extraction therapy of lower 1st premolars and paoo were included in the study. exclusion criteria: * smokers and subjects with severe crowding of anterior teeth, periodontitis and systemic diseases were excluded from the study.
comparison of the hyperq versus conventional electrocardiogram (ecg) to detect ischemia

Conditions: Coronary Artery Disease

Summary: the purpose of the investigation is to verify the efficiency of the hyperq™ system in detecting exercise induced ischemia, with higher specificity and sensitivity than conventional ecg stress testing. the study will be carried out by applying the hyperq™ system during cycle ergometer stress testing in patients who are referred for angiography at the department of cardiology, essen university hospital, essen, germany. the hyperq™ results will then be compared to the standard ecg stress test results using the angiography results as the gold standard. the study will be considered successful if analysis of the hyperq provides a statistically significant improvement over the diagnostic accuracy of conventional ecg stress testing analysis.


Eligibility criteria:
inclusion criteria: * a patient who was referred to angiography. * a patient who is able (i.e., no contraindications) to perform an exercise stress test * a patient who signed an informed consent form. exclusion criteria: * contraindications for an exercise test. * wolff-parkinson-white (pre-excitation) syndrome. * left bundle branch block, complete right bundle branch block or qrs duration \> 120 ms, change in qrs morphology during exercise. * atrial fibrillation or significant ventricular arrhythmia * treatment with digoxin. * pacemaker. * having taken beta blockers within 24 hours before the exercise test. * pregnancy or suspected pregnancy.

Keywords: angiography exercise testing high frequency ecg coronary artery disease
melanoma inhibitory activity (mia): a serological marker for metastatic uveal melanoma

Conditions: Melanoma; Radiotherapy; Metastatic Disease

Summary: uveal melanoma is the most common primary intraocular tumor in adults. most tumors metastasize to the liver. so far no sensitive or specific serological tumor marker is routinely used. the marker "melanoma inhibitory activity" is a promising marker. study hypothesis is to detect metastatic lesions in an early stage. this would increase life expectance of our patients

serum is taken from each melanoma patient at every follow up after signed concent. with elisa the marker mia is evaluated. an increase of mia serum level will lead to search for metastasis by oncologists.

Eligibility criteria:
inclusion criteria: * uveal melanoma (with/without overt metastatic disease)

Keywords: uveal melanoma metastatic disease
interactive technology for media literacy drug prevention in community groups

Conditions: Substance Use

Summary: this phase ii sttr will evaluate an interactive, self-paced, e-learning media literacy intervention, real media, to prevent youth substance use among youth in the 4-h organization. participating 4-h clubs will be randomly assigned to use the curriculum or continue current practices with the option for delivery at the end of the study. 4-h members (ages 13-15) will complete a pretest, immediate posttest and follow-up posttests at 3 and 9 months to assess effects.

real media is an interactive, self-paced, e-learning media literacy curriculum that prevents adolescent substance use among 13-15-year-old teens. the program consists of 5 levels. levels 1 to 4 are 15-25 minutes; level 5 allots time for message production done offline. activities lead students to engage in critique and analysis of arguments present/absent from pro-atod and other popular product messages and to begin the process of refuting and counter-arguing these messages. these skills are reinforced in level 5 using an active involvement strategy in which youth plan and produce anti-atod messages. users first plan their message via an online worksheet, which requires engagement with and application of media literacy concepts rather than focus exclusively on technology and/or production features. next, participants design their posters/videos and upload their messages to a social media site as part of a contest, where they recruit peers and family to like or comment on their message.

Eligibility criteria:
inclusion criteria: * 4-h members and leaders must belong to a participating club in pennsylvania, ohio, new jersey, west virginia, or maryland * members must be between the ages of 13-15 * club leaders must be at least 21 years of age * written parental consent and assent from members * written consent from club leaders (online assent) exclusion criteria: * the inability to speak or read american english * access to and the ability to use a computer, or navigate the internet * for youth, lack of parental consent/youth assent/leader consent
virtual coronary intervention and non-invasive fractional flow reserve (ffr)

Conditions: Coronary Artery Disease

Summary: the investigators examined the feasibility of treatment planning using virtual coronary revascularization and fractional flow reserve (ffr) ct before the invasive procedures.


Eligibility criteria:
inclusion criteria: * significant stenosis at ct angiography * normal ejection fraction on echocardiography * informed consented patient exclusion criteria: * total occlusion and collateral flow to target vessel * av conduction abnormality * left ventricular hypertrophy * significant valvular heart or primary myocardial disease

Keywords: coronary artery disease ct computational flow dynamics
the effects of peanuts and peanut products on glucose control and vascular function

Conditions: Cardiovascular Disease

Summary: pilot study data have demonstrated that peanuts ameliorate the postprandial glucose and insulin response when incorporated into an acute high fat/high glucose meal. however, it is unclear whether acute consumption of peanuts can also influence vascular function. this study will therefore evaluate the effects of acute peanut consumption on vascular function, glycemic control, and plasma lipids. the hypothesis is that that addition of peanuts to a high fat/high glucose meal will reduce the production of triglycerides, glucose, and improve endothelial function as measured by flow-mediated dilation (fmd).


Eligibility criteria:
inclusion criteria: * 20-50 years of age * ldl-c below 160 mg/dl * triglyceride below 350 mg/dl * blood pressure within normal ranges (below 140/90 mmhg) * not taking medication for elevated lipids, blood pressure or glucose exclusion criteria: * allergies to peanuts or dairy products * known intolerance for high fat meals * history of cardiovascular disease (cvd), kidney disease, diabetes or inflammatory diseases such as gi disorders and arthritis * use of non-steroidal anti-inflammatories or immunosuppressants * conditions requiring the use of steroids * use of medication or supplements for elevated lipids, blood pressure or glucose * donation of blood or plasma during the study * history of thyroid disease * women * lactose intolerance
effect of the nasal provocation on the breathing style

Conditions: Birch Pollen Allergy; Healthy Control Subjects

Summary: the purpose of this study is to find out how the provocation of the nose changes breathing style (specifically, frequency and tidal volume changes)

it is intended to clarify on both healthy and birch pollen allergic adults how the provocation of the nose with the birch pollen, dilutant and xylometazoline affect the breathing style (breathing pattern) and how these possible changes could be controlled in the measurement of the breathing with respiratory effort belts. in addition to this, our intention is to clarify the effect of the facial mask on the breathing. the allergic and control subjects undergo nasal provocation in 2 sessions. the first is done with birch pollen extract (should block the nose in allergic subjects) and the second with xylometazoline (should open the nose). the mask group undergo similar measurements without nasal exposures. the second objective of the study is to clarify if there are differences between the allergic and control subjects in the function of the autonomous nervous system during these provocations. this is done with the heart rate variability analysis method.

Eligibility criteria:
inclusion criteria: * birch pollen allergic subjects must have clear nasal symptoms during the birch pollen season and birch specific ige \>= 0.70 * healthy subjects: birch specific ige \< 0.35 * the subjects are not allowed to be under medication that affects the function of their nose during a specific time period before the measurement * they have to be free of any acute respiratory symptoms during the prior two weeks to the measurements * before measurement, they are not allowed to have heavy meal or sport * they are not allowed to have caffeine or other stimulants for 12 hours or alcohol for 24 hours. exclusion criteria: * heart diseases * brain circulatory disorders * surgical operations of nose * chronic nasal symptoms * pregnancy * smoker

Keywords: birch pollen allergy breathing pattern exposure
visibility™ iliac study

Conditions: Peripheral Arterial Disease; Claudication

Summary: the visibility iliac study is a prospective, multi-center, non-randomized study confirming the safety and effectiveness of stenting using the visi-pro™ balloon expandable stent system for the treatment of stenotic, restenotic or occluded lesions in the common and external iliac artery.


Eligibility criteria:
inclusion criteria: * patient has claudication as defined by a rutherford clinical category score of 2, 3 or 4. * evidence of ≥ 50% stenosis, restenosis or occlusion of target lesion(s) located in the common iliac artery and/or external iliac artery. * willing to comply with all follow-up evaluations at the specified times. * provides written informed consent prior to enrollment in the study. exclusion criteria: * previous implantation of stent(s) in the target vessel. * received endovascular treatment of the target lesion within six months prior to the index procedure. * known hypersensitivity to contrast material that cannot be adequately pretreated. * known hypersensitivity to 316l stainless steel. * life expectancy of less than 12 months

Keywords: peripheral arterial disease claudication stent visi-pro iliac artery
peginterferon lambda-1a for the prevention and treatment of sars-cov-2 (covid-19) infection

Conditions: Sars-CoV-2 Infection

Summary: this is a phase 2b prospective, randomized, single-blind, controlled trial of a single subcutaneous injection of peginterferon lambda-1a versus placebo for prevention of sars-cov-2 infection in non-hospitalized participants at high risk for infection due to household exposure to an individual with coronavirus disease (covid-19). the study will also evaluate the regimens participants with asymptomatic sars-cov-2 infection detected at study entry. all participants will be followed for up to 12 weeks.


Eligibility criteria:
inclusion criteria: * willing and able to provide written informed consent * peripheral capillary oxygen saturation (spo2) ≥ 95% on room air at screening * age ≥18 years exclusion criteria: * hospitalized or impending hospitalization at the time of screening * symptoms of cough, fever or shortness of breath within 72 hours * prior or current treatment with other experimental or approved agents targeting sars-cov-2 or sars-cov-1 * positive pregnancy test * active autoimmune disease or sarcoidosis (with the exception of controlled thyroid disease) * active decompensated liver disease (ascites, encephalopathy) * active congestive heart failure

Keywords: sars-cov-2 covid-19 lambda interferon
serum metrnl concentration in type 2 diabetes

Conditions: Diabetes Mellitus, Type 2

Summary: the investigators measured serum metrnl levels in newly diagnosed patients with type 2 diabetes (t2dm) compared with normal glucose tolerance or prediabetes and explored the correlations between its serum levels and various metabolic parameters


Eligibility criteria:
inclusion criteria: * subjects who have not been diagnosed diabetes mellitus exclusion criteria: * person with diabetes who were treated with oral hypoglycemic agent or insulin * individuals with type 1 diabetes, gestational diabetes, active hepatitis/liver cirrhosis, chronic renal failure on hemodialysis, congestive heart failure, or other known major disease
longitudinal study of chronic wounds using novel wound measurement technologies

Conditions: Diabetic Foot Ulcer

Summary: an open, non-randomised longitudinal study of diabetic foot ulcers receiving standardised treatment, over a 16 week period conducted at out-patient level, utilising novel optical wound measurement technologies.

diabetic foot ulcers are a major burden on the healthcare system, and it is highly desirable to develop a practical, reliable, non-invasive means of diagnosing, assessing and measuring wound healing, so as to provide wound care specialists with key data with which to make effective decisions for clinical management. optical coherence tomography (oct) is a novel technique of imaging of cutaneous tissue. using low-power infrared light, it is a non-invasive in-vivo imaging technique which provides resolution of \<10microns to a depth of 1 - 1.25 mm in skin, (adequate to resolve capillaries) utilizing the optical scattering characteristics of tissue to provide imaging contrast. this open, non-randomised, observational study will assess the feasibility of using oct to diagnose chronic diabetic foot ulcers. one cohort of 15 patients will be scanned over a 16 week period and results studied to determine whether there is an association between rate of wound healing and oct measurements.

Eligibility criteria:
inclusion criteria: * defining abpi ≥0.5 - \<1.2 * patients with dfu for over 4 weeks but less than 1 year duration. dfu resulting from neuropathy will be included. * neuropathy scores defined by 10g semmes-weinstein monofilament tests at 10 sites on plantar and dorsal surfaces exclusion criteria: * patients with uncontrolled diabetes, the charcot foot, cancer (except non-melanoma skin cancer in the limb), decompensated cardiac failure, clinically significant renal failure, history of stroke or significant peripheral arterial disease, or those who are pregnant, or on a waiting list for interventional therapy.
impact of keratinized mucosa augmentation on treatment outcomes of peri-implant mucositis

Conditions: Peri-implant Mucositis

Summary: this study aims to observe the effects of keratinized mucosa width on peri-implant tissues by evaluating clinical and biochemical parameters. the main question it aims to answer is: would increasing the width of the keratinized mucosa with free gingival graft (fgg) in peri-implant mucositis be beneficial in terms of clinical periodontal parameters and peri-implant crevicular fluid levels of inflammatory cytokines compared to non-surgical therapy alone? our study consists of 4 groups: peri-implant healthy group with sufficient keratinized mucosa (≥ 2mm) (n=16), peri-implant mucositis group with sufficient keratinized mucosa (n=16), peri-implant mucositis group with insufficient keratinized mucosa (\< 2mm) receiving only non-surgical treatment (n=16), peri-implant mucositis group with insufficient keratinized mucosa receiving fgg in addition to non-surgical treatment (n=16). clinical and biochemical measurements will be recorded at the baseline, 1st month, 4th month and 7th month of the study. peri-implant crevicular fluid samples will be collected at baseline, 1st month, 4th month and 7th month. il-1β, rankl, opg levels, and rankl/opg ratio will be analyzed from collected samples. researchers will evaluate the possible benefits of fgg application in addition to non-surgical therapy by comparing the biochemical and clinical changes in areas with and without fgg application in the treatment of peri-implant mucositis.


Eligibility criteria:
inclusion criteria: * individual dental implants with a fixed prosthetic restoration that has been functional for at least 1 year * no systemic disease and medication use that may affect periodontal or peri-implanter tissues * not receiving periodontal treatment in the last 6 months * volunteering to participate in the study exclusion criteria: * prosthetic restorations with an excessive contour which do not allow peri-implant pocket measurement * being pregnant or breastfeeding, * autoimmune and/or inflammatory diseases of the oral cavity, * active periodontal disease * smokers (≥ 10 cigarettes per day) * improperly positioned implants
a randomized, placebo-controlled trial of prednisone in refractory restless legs syndrome: a pilot study

Conditions: Restless Legs Syndrome

Summary: restless legs syndrome is a common sleep-related movement disorder that affects up to 15% of the population in north america, characterized by an uncomfortable urge to move the legs. this has been associated with poor quality of sleep and overall decreased quality of life. chronic inflammation has been implicated as a key mediator of the low intracranial iron stores that characterize restless legs syndrome (rls). current medications for rls target concomitant low serum iron levels or the dopaminergic pathway, but none target the inflammatory pathway. a novel therapy that focuses on inflammation would allow for additional research into the role of inflammation and cytokines in the development of rls, and potentially unlock a new class of medications to treat patients with rls. a small amount of prior evidence suggest that rls symptoms improve with steroids, with associated improved quality of life, and with decreasing hepcidin levels as a biomarker of symptom severity. this pilot study, using an rct design, serves to assess the efficacy of glucocorticoids in the alleviation of rls symptoms, which would further anchor the association between rls, inflammation, and one of its potential mediators - hepcidin. by giving a prednisone taper versus placebo, this study primarily aims to assess the effect of glucocorticoids on 1) decreasing rls symptom severity. this study also aims to measure 2) objectively measured improvement in sleep, 3) changes in baseline and post-treatment hepcidin levels, and 4) prevalence of adverse events including psychosis and weight gain. rls can be a debilitating disease and several non-traditional medications have been tested but with unequivocal results. glucocorticoids may be an easily accessible and affordable key to better quality of life for rls patients, especially those with refractory rls.


Eligibility criteria:
inclusion criteria: * outpatient * refractory rls defined as restless legs unresponsive to monotherapy with tolerable doses of first-line agents due to reduction in efficacy, augmentation, or adverse effects * irls score greater than 15 exclusion criteria: * pregnancy * prescence of iron deficiency anemia * history of diabetes mellitus type 1 and type 2 * history of uncontrolled hypertension * presence of immunosuppression (hiv or currently taking immunosuppressants) * any prior adverse reaction to glucocorticoids * history of dementia or major psychiatric diseases with psychosis * lack of ability to understand the experimental protocol and to adequately communicate in english

Keywords: refractory rls rls restless legs syndrome