Kornimate/medical-research-clean huggingface dataset:
cognitive muscular therapy for patients with long-covid and breathing pattern disorder

Conditions: Long COVID; Respiratory Disease

Summary: the aim of the study is to test a treatment known as "cognitive muscular therapy (cmt)" for reducing breathlessness and improving autonomic function in patients with long-covid.

a key symptom of long-covid is dysfunctional breathing, characterised by an alteration in the muscular and mechanical control of breathing, such as altered movement/coordination of diaphragm and ribs. long-covid patients also experience symptoms such as dizziness and fatigue, which have been linked to dysautonomia (dysfunction of the nervous system controlling automatic body functions). importantly, dysautonomia is connected to alterations in breathing mechanics. specifically, rapid breathing, high in the chest, is associated with increased activity in the fight-or-flight system and decreased activity in the rest-and-repair system. given this link, interventions capable of improving breathing mechanics could alleviate many long-covid symptoms. however, current breathing retraining methods lack visualisation of breathing mechanics and do not integrate a whole-body approach to improving postural control. we have developed a clinical system which can visualise breathing mechanics in real-time, providing patients with a "window into their body". we propose to integrate this system within a new intervention, known as cognitive muscular therapy (cmt). cmt integrates psychological informed physiotherapy with training to reduce overactivation of postural muscles which can interfere with the mechanics of breathing. we propose to test this combined intervention on 20 people with long-covd to understand if we can improve respiratory function and symptoms associated with dysautonomia. if successful, this pilot study could pave the way for large-scale studies in long-covid

Eligibility criteria:
inclusion criteria: * above 18 years old * experience moderate/severe breathlessness, quantified using the modified covid-19 yorkshire rehabilitation scale (c19-yrsm) scale. * speak and understand english sufficiently to read the information sheet and sign the consent form * ability to stand without any assistive device for at least 20 minutes (to ensure sufficient capacity to complete the intervention) exclusion criteria: * dementia or other major cognitive impairment * bmi \>32 (as increased subcutaneous fat prevents use of breathing measurement system) * current smoker or smoked regularly within last 6 months * any cardiorespiratory disease that requires medical intervention (except asthma management) * currently receiving physiotherapy-based treatment for lc or breathing pattern disorder * significant respiratory co-morbidity (e.g. copd, uncontrolled asthma)
a study of two approved drugs in the treatment of postoperative dental pain (0966-182)

Conditions: Postoperative Pain

Summary: the purpose of this study is to compare the safety and effectiveness of two approved drugs in the treatment of pain following dental surgery.

the duration of treatment is 24 hours.

Eligibility criteria:
inclusion criteria: * impaction of a molar tooth requiring removal exclusion criteria: * known allergy to the study drugs

Keywords: dental surgery molar removal
inflammatory cell trafficking after myocardial infarction

Conditions: Myocardial Infarction; Inflammation

Summary: myocardial infarction (heart attack) is usually the consequence of rupture of a fatty 'plaque' in a heart artery. the presence of this fat and debris causes the propagation of a blood clot and blockage of the artery. the heart muscle normally supplied by the artery becomes deprived of oxygen and, if starved for long enough, this area of muscle dies. much of the heart muscle damage is caused by overactivation of inflammatory cells. whilst inflammation can be beneficial in healing processes, there is accumulating evidence that overactivation of inflammatory processes contributes to further muscle damage and cell death during myocardial infarction. we have recently developed a means of labelling human blood cells with 'nanoparticles' of iron oxide which can then safely be reinjected into the blood to allow the cells to be tracked and seen in the body using a conventional magnetic resonance scanner. in the proposed study we aim to recruit patients with recent heart attacks to perform similar cell labelling and reinjection of labelled cells into the same volunteer's blood stream via the arm to track the fate of the blood cells over the course of days to months. we think that the labelled inflammatory cells will 'home' to the site of the heart attack and will be visible using magnetic resonance imaging (mri) of the heart. we aim not only to highlight the role of inflammatory cells in myocardial infarction, but also propose that, if successful, this technique could be used in the future to assess the effects of antiinflammatory treatments currently being developed for the treatment of patients with heart attacks. the technique could also be extended to allow labelling of other cell types, including stem cells, to let us further understand how these cells may contribute to repair of damaged organs including the heart.


Eligibility criteria:
inclusion criteria: * presentation with acute st segment elevation myocardial infarction: * 1 mm st elevation in at least two contiguous limb leads, or * 2 mm st elevation in at least two contiguous praecordial leads, or new onset bundle branch block * successful treatment with primary percutaneous coronary intervention restoration of timi grade 3 flow in infarct-related artery * troponin i ≥10 iu/ml at 12 hours after the onset of chest pain * age 18 - 80 years exclusion criteria: * left main stem or severe multi-vessel coronary artery disease * continued symptoms of angina at rest or minimal exertion * atrial fibrillation * symptomatic heart failure; killip class ≥2. * hepatic or renal failure (estimated glomerular filtration rate \<25 ml/min) * terminal illness or malignancy * anaemia * contraindication to magnetic resonance imaging * hepatitis b, hepatitis c, htlv, hiv or syphilis infection * patients at risk of allergy to protamine (fish allergy, infertile men, previous vasectomy)

Keywords: myocardial infarction magnetic resonance imaging nanoparticles mononuclear cells cell tracking
comparing hall vs conventional technique in placing preformed metal crowns from sudan

Conditions: Caries, Dental

Summary: preformed metal crowns (pmcs) have high success rates in restoring primary molars in children but they were not generally used by dentists, especially in developing countries due to its demand of high clinical skills with the conventional technique (ct). the biological approach, hall technique (ht), requires less training and can be placed by less experienced dental operators including therapists. previous studies were mainly carried out in developed countries. the aims were to investigate and compare the efficacies and cost-effectiveness of pmcs placed by these two techniques.

a prospective randomised control trial design was used. the study was carried out in a dental practice in sudan, an under-developed country with lower social economic group. children between 5-8 years were invited and selected if they met the inclusion criteria. only those who had 1-2 carious primary molars needing pmcs were randomised. the pmcs were placed by a dentist in the ct arm and by a therapist in the ht arm. the children were follow up every 6 months up to 2 years. the demographic details, periodontal health, occlusion, children anxieties, and procedure time were recorded. the kaplan-meier survival rates for each arm were calculated. the incremental cost effectiveness ratio (icer) was calculated using the results and the local salaries

Eligibility criteria:
inclusion criteria: * healthy children with class i or class ii carious primary molars exclusion criteria: * had a compromised medical history * were pre- or un-cooperative to have clinical examinations * lived in remote villages and were unlikely to return for follow-up * had teeth with pain or sepsis * had teeth with caries extended in pulp either from clinical or radiographic examinations
beta-arrestins and response to venlafaxine in major depressive disorder (mdd) (deparrestclin)

Conditions: Major Depressive Disorder; Major Depressive Episode

Summary: predictive factors and biomarkers of response to antidepressants in major depressive disorder are scarce. beta-arrestins are proteins which inhibit g protein coupled receptors and desensitize serotonergic and dopaminergic receptors. the study hypothesis is that beta-arrestins 1 and 2 are predictive factors and biomarkers of response to antidepressants in major depressive disorder. in a controlled prospective open naturalistic monocentric 3-month study, 60 patients with a major depressive disorder requiring a treatment with venlafaxine will be included and assessed before treatment, 1 month and 3 months post-treatment. 20 controlled healthy subjects matched for age and gender will also be assessed. the beta-arrestin pathway will be assessed using genetic polymorphisms, peripheral blood mononuclear cell measures and functional pathway. antidepressant response will be assessed using depression scales, olfaction and memory as surrogate markers of neurogenesis.

rationale: predictive factors and biomarkers of response to antidepressants in major depressive disorder are scarce. beta-arrestins are proteins which inhibit g protein coupled receptors and desensitize serotonergic and dopaminergic receptors. hypothesis: the study hypothesis is that beta-arrestins 1 and 2 are predictive factors and biomarkers of response to antidepressants in major depressive disorder. method: in a controlled prospective open naturalistic monocentric 3-month study, 60 patients with a major depressive disorder requiring a treatment with venlafaxine will be included and assessed before treatment, 1 month and 3 months post-treatment. 20 controlled healthy subjects matched for age and gender will also be assessed. assessments: the beta-arrestin pathway will be assessed using genetic polymorphisms, peripheral blood mononuclear cell measures and functional pathway. antidepressant response will be assessed using depression scales, olfaction and memory as surrogate markers of neurogenesis.

Eligibility criteria:
inclusion criteria: * major depressive disorder * current major depressive episode * hamilton depression rating scale score \> 18 * requiring a new treatment with venlafaxine * written informed consent exclusion criteria: * bipolar disorder * psychotic disorder * unstable somatic condition * contraindication to cerebral rmi * current treatment with mood stabilizers

Keywords: major depression antidepressant drug beta-arrestin biomarker predictive factor
intelligence changes following minor surgery

Conditions: Hypospadia; Phimosis; Inguinal Hernia

Summary: animal studies showed that many general anesthetics might result in neuron apoptosis and neurocognitive impairment in the developing brain. however results from human studies are conflicted. in present study, the investigators examined the association between early exposure to anesthesia and surgery for minor surgery and intelligence changes in adolescence using the wechsler intelligence scale for children.


Eligibility criteria:
inclusion criteria: 1. born from 1995 2. male 3. parents or guardian agree to attend this study 4. undergone minor surgery (repair of hypospadias, phimosiectomy, cryptorchidectomy or cryptorchidopexy and repair of inguinal hernia) 5. children who scarify the no.1 to no.3 but no experience of any surgery. 6. those who undergone minor surgery in renji hospital 4-6years ago. exclusion criteria: 1. any congenital central nervous system diseases 2. any congenital heart diseases 3. any congenital dysgnosia 4. birth weight less than 2kg 5. ever been hypoxic encephalopathy when birth

Keywords: anesthestics minor surgery wechsler intelligence scale for children cognitiion
a 12-week, multicenter, safety and dose-ranging study of 3 oral doses of tch346 in patients with amyotrophic lateral sclerosis

Conditions: Amyotrophic Lateral Sclerosis

Summary: this study is the first to be performed in amyotrophic lateral sclerosis (als) patients with the novel compound tch346. its purpose is to evaluate the safety and clinical effects of 3 dose levels of tch 346 compared to placebo in patients with a clinical diagnosis of laboratory-supported probable, probable or definite als. the study will require patients to visit the study center a total of at least 7 times over the course of up to 14 weeks. the study consists of 2 phases: a screening phase (up to 2 weeks) when patients will be evaluated for eligibility to participate in the study, and a double-blind treatment phase (12 weeks) when patients will receive daily doses of either tch346 or placebo and will be evaluated for clinical effects. in addition, patients eligible to participate in this study will be required to have 3 magnetic resonance spectroscopic (mrs) scans. the mrs is a non-invasive, painless, "brain scan". the mrs will require traveling to a designated center in montreal, canada, which is very experienced in performing such mrs scans in als patients.


Eligibility criteria:
* clinical diagnosis of laboratory-supported probable, probable, or definite als; * have sporadic or familial als; * have shown als symptom onset for no more than 3 yrs., inclusive, prior to randomization; * fvc of \>60%; * ability to tolerate mrs evaluation

Keywords: (als)
water-filtered infrared-a radiation in patients with hand osteoarthritis

Conditions: Hand Osteoarthritis

Summary: the aim of this clinical trial is to evaluate the effects of water-filtered infrared-a radiation on patients suffering from hand osteoarthritis. the main questions it aims to answer are: * does water-filtered infrared-a radiation reduce pain and improve the function of finger joints over time? * are patients satisfied with the treatment results when compared to those who were on a wait-list?


Eligibility criteria:
inclusion criteria: * diagnosis of finger polyarthritis (confirmed by a specialist, radiological findings available) * local pain for more than 50% of the day in the past 3 months. * subjective pain intensity of local pain in the last 24 hours on a vas scale of 0 to 10 being \>4. * no planned local treatment in the next 6 months. * no planned intra-articular injections within the next 6 months. * the patient must be able to understand the study explanations and appropriately follow the instructions of the investigating physician. exclusion criteria: * chronic inflammatory joint diseases. * poor general health. * febrile diseases. * fibromyalgia syndrome. * psychotic disorders. * severe comorbidities. * acute unclear skin diseases. * heat urticaria. * painful diseases/diagnoses of the shoulder and/or arm. * lymphatic vessel diseases (lymphedema, lymphangitis). * porphyria. * pain-associated diseases/diagnoses of the shoulder and/or arm. * intra-articular injections or arthroscopies within the last 3 months. * previous or planned surgical procedure on the affected joints in the last 8 weeks or in the upcoming 6 months. * intake or application of photosensitizing drugs or extracts (e.g., porphyrins, tetracyclines, sulfonamides, psoralenes, st. john's wort). * systemic medication with glucocorticoids or immunosuppressants. * pain medication with opioid analgesics. * known pregnancy. * concurrent participation in another clinical trial.
safety and efficiency of γδ t cell against liver cancer

Conditions: Liver Cancer

Summary: in this study, effects of γδt cells on human liver cancer in combination with tumor reducing surgery, for example, cryosurgery going to be investigated.

a liver tumor will be removed using tumor reducing surgery such as cryosurgery.pbmc of the patient will be separated from peripheral blood. after making them potential cancer killer γδ t cell and dc-cik, they will be infused to the patients as an immunotherapy treatment. note: originally, our designed proposal was to use autologous pbmcs from cancer patients to ex vivo expand vγ9vδ2-t cells, and then perform adoptive transfer therapy. however, pbmcs of majority of cancer patients could not be effectively expanded, including cell number, cell purity and cell function could not meet the requirements of reinfusion. meanwhile, those patients could not tolerate 100ml of blood drawing for culture every 2 \~ 3 weeks. therefore, we submitted new clinical study application to the ethical committee of the fuda hospital affiliated with jinan university (guangzhou, pr. china) by changing the autologous protocol with the allogeneic protocol. after the allogeneic protocol was approved, we adapted allogeneic cells instead of autologous in our subsequentially clinical study.

Eligibility criteria:
inclusion criteria: 1. age: 18-75 2. karnofsky performance status \>50 3. diagnosis with liver cancer based on histology or the current accepted radiological measures 4. classification tumor,nodes,metastasis-classification(tnm) stage: ⅱ,ⅲ,ⅳ 5. will receive cryosurgery, ire, gd t cells 6. life expectancy: greater than 3 months 7. ability to understand the study protocol and a willingness to sign a written informed consent document exclusion criteria: 1. patients with other kinds of cancer 2. history of coagulation disorders or anemia 3. patients with heart disease

Keywords: immunotherapy, γδ t cell, liver cancer
life skills intervention for adolescents perinatally infected with hiv

Conditions: HIV Infections

Summary: the life skills intervention model is designed to help adolescents promote their physical and mental health through cognitive and behavioral techniques (e.g., problem solving, coping, and communication skills) designed to help them achieve social and personal competencies used to manage various life challenges.

one of the salient advantages of this intervention model is that it has been developed and implemented in several studies with adolescents. however, data concerning the effects of this model are much less extensive with adolescents perinatally infected with hiv. the proposed study is designed to address this gap in knowledge by conducting a pilot intervention tailoring the life skills intervention to the needs of young adolescents, perinatally infected with hiv, and to their primary caregivers. given the emphasis on peer group interaction, the proposed intervention model also has the potential to reduce some of the social isolation imposed by the experiences related to hiv infection by creating opportunities for adolescents to interact with others who are managing comparable stressors and treatment regimens.

Eligibility criteria:
inclusion criteria: * clinically-identified hiv-1 infected participants 11-14 years of age and their primary caregivers. * hiv status has been disclosed to the adolescent. * caregiver is the legal guardian of the adolescent as indicated by the medical team. * adolescent lives with the caregiver * adolescent and caregiver speak and understand english. exclusion criteria: * caregiver consent or permission denied or adolescent does not assent. * adolescent diagnosed as mentally retarded as previously reported or confirmed through chart review. * adolescent and/or caregiver too medically fragile. medically fragile is functionally defined as being physically unable to attend the group.

Keywords: hiv aids adolescent hiv positive
hypopressive exercise associated with strength and resistance training in women treated for gynecological cancer

Conditions: Gynecologic Cancer

Summary: the study aims to evaluate the effects of 4 weeks of hypopressive exercise associated with resistance training and aerobic exercises on fatigue, symptoms of urinary incontinence, sexual function and quality of life in women treated for gynecological cancer compared to a group that will perform conventional training. .

objective: to evaluate the effects of 4 weeks of hypopressive exercise associated with resistance training and aerobic exercises on fatigue, symptoms of urinary incontinence, sexual function and quality of life in women treated for gynecological cancer compared to a group that will perform conventional training. methods: this will be a single-blind randomized clinical trial. a hypopressive exercise intervention associated with resistance training and aerobic exercise will be carried out during twelve telerehabilitation sessions. patients over 18 years of age who are diagnosed with gynecological cancer and who are indicated for radiotherapy or chemotherapy will participate. patients will be randomly assigned to an experimental group of hypopressive exercises associated with resistance training and aerobic exercises or conventional training. fatigue, quality of life, symptoms of urinary incontinence and sexual function will be evaluated before and after the intervention. discussion: the results of this clinical trial will determine the impact of conventional training associated with hypopressive exercise on the negative side effects of cancer treatment in women with gynecological cancer.

Eligibility criteria:
inclusion criteria: * candidates must have a medical diagnosis of gynecological cancer * participants should have an indication for chemotherapy or radiotherapy, associated or not with pelvic lymphadenectomy * women with an age range over 18 years with a limit of up to 60 years * participants who are able to practice physical activity exclusion criteria: * recurrence of gynecological cancer * presence of lymphedema in the lower limb, measured by cytometry of the lower limb with a tape measure; asymmetries of more than 2 cm between the limbs were considered edema * diagnosis of metastasis * heart disease

Keywords: exercise therapy neoplasms fatigue quality of life urinary incontinence
decrease artery occlusion by distal radial arterial cannulation, observational study

Conditions: Acute Coronary Syndrome; Procedural Complication; Outcome, Fatal

Summary: the site of arterial access for coronary angiography and intervention has been the focus of research for decades as it is the source of major complications. transradial access (tra) reduces complications among patients undergoing percutaneous coronary procedures but is reported with the complication of radial artery occlusion (rao) that limits the radial artery for future needs. distal radial access (dtra) has recently gained global popularity as an alternative access route for vascular procedures. among the benefits of dtra are the low risk of entry site bleeding complications, the low rate of radial artery occlusion, and improved patient and operator comfort. this study aims to reveal the feasibility and safety of dtra and routine tra procedures in acute coronary syndrome patients. the primary endpoints are forearm radical occlusion rate and major adverse cardiovascular events (maces) in the two groups. investigators conduct this retrospected analysis to demonstrate the difference of the two procedure of cannulation.


Eligibility criteria:
inclusion criteria: * presence of a pulse in the snuffbox exclusion criteria: * absence of pulse * ultrasound indication of arterial occlusion or severe calcification * severe forearm artery malformation * patients with severe liver and renal failure, or abnormal coagulation function * established cardiogenic shock * history of previous coronary artery bypass grafting and radial artery use. * raynaud's disease in the medical history

Keywords: distal radial access radial artery occlusion major adverse cardiovascular events