Kornimate/medical-research-clean huggingface dataset:
clinical efficacy of heparin and tocilizumab in patients with severe covid-19 infection

Conditions: Covid19

Summary: the covid-19 infection primarily manifests itself as a respiratory tract infection, although new evidence indicates that this disease has systemic involvement involving multiple systems including the cardiovascular, respiratory, gastrointestinal, neurological, hematopoietic and immune systems. recent studies have shown that in its pathophysiology, inflammation and thrombogenesis predominate, especially in the severe forms of covid-19. thus, the investigators hypothesized that the use of heparin and tocilizumab could potencially reduce inflammation and thrombogenesis in patients with severe covid-19 infection, improving patients outcomes and survival.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years; * informed consent form signed by the patient or guardian or by audio with the guardian; * positive result for covid-19 in pcr (polymerase chain reaction) in nasopharyngeal swab or tracheal secretion up to 10 days before the inclusion and radiological evidence of covid-19, by chest radiography or chest computed tomography; * need for ≥ 4 l of supplemental oxygen to maintain peripheral oxygen saturation equal to or greater than 93% or need for invasive mechanical ventilation. exclusion criteria: * risk of bleeding: * clinical: active bleeding, major surgery in the last 30 days, gastrointestinal bleeding within 30 days; * laboratory: platelet count \ 2 or aptt\> 50s; * known or suspected adverse reaction to ufh, including heparin-induced thrombocytopenia (tih); * adverse reaction or allergy to tocilizumab; * use of any of the following treatments: ufh to treat a thrombotic event within 12 hours before inclusion; hpbm in therapeutic dose within 12 hours before inclusion; warfarin (if used 7 days before and if inr greater than 2; thrombolytic therapy within 3 days before; and use of glycoprotein iib / iiia inhibitors within the previous 7 days; * pregnant or lactating; * absolute indication of anticoagulation due to atrial fibrillation or diagnosed thromboembolic event; * refusal by family members and / or patient; * active tuberculosis; * bacterial infection confirmed by culture; * neutropenia (\<1000 neutrophils / mm3); * use of another immunosuppressive therapy that is not a corticosteroid; * septic shock.

Keywords: covid-19 heparin tocilizumab
smoking and ventricular repolarization

Conditions: Sudden Cardiac Death; Prolonged QTc Interval

Summary: randomized controlled trial of acute use of electronic cigarette or tobacco cigarette on parameters of ventricular repolarization.

non-user or chronic electronic cigarette (ec) users will use an ec or control on three occasions:1) ec with nicotine, 2) ec without nicotine, 3) empty ec (control). chronic tobacco cigarette (tc) smokers will use a tc or control on three occasions: 1) tc with nicotine (subject's own brand), 2) research tc with very low nicotine, 3) straw (control). the electrocardiogram will be recorded before and after acute exposures and analyzed for parameters representative of ventricular repolarization.

Eligibility criteria:
inclusion criteria: * healthy non-smokers chronic tc smokers (non-e-cig users) chronic ec smokers (non-tc smokers) exclusion criteria: * cardiac disease, respiratory disease, diabetes

Keywords: e-cigarettes tobacco cigarettes nicotine ventricular repolarization
measurement of blood perfusion in response to loading in patients with wounds

Conditions: Wound Formation

Summary: the purpose of this study is to monitor the skin blood flow in the lower leg, with different levels and types of applied loads. these loads will not be placed over the patient's wound nor will they be higher than loads the skin normally experiences in daily activities. the results of this research will help investigators understand the development of pressure ulcers, commonly known as bedsores and stasis ulcers.


Eligibility criteria:
inclusion criteria: * patients are eligible if he/she has a wound on one or both legs. exclusion criteria: * under the age of 18 * individuals with mental illness * individuals who are unable to sit for an hour * individuals whose wound care method prohibits testing
lifestyle practices with chronic diseases among different professionals

Conditions: Chronic Diseases in Adolescence; Cardio Vascular Disease; Diabetes Type 2

Summary: a qualitative study conducted in 2018 exploring socio-cultural factors impacting adherence to type 2 diabetes therapy in rural sargodha featured respondents who were primarily doctors, patients, and. diet, exercise, and smoking were all variables. the void we investigators will fill will be comprised of several professionals assessing sleep and sedentary lifestyle. a book on anthropology published in 2021 shows the gap are still the same about sedentary life style. the investigators aim to determine lifestyle practices in relation to sedentary behaviour in different occupations \& comparing which profession is prone to chronic diseases in accordance to lifestyle practices

considering all the numerous variables that can have an effect on someone's health, it seems obvious that prior research into all the potential determinants of a health intervention's success is necessary. care for a sickness requires knowledge of both the disease itself and the patient's social and cultural context, thus it's important to learn about both. since diabetes is chronic, it must be managed permanently. idf's most recent projections for 2019 show that the prevalence of diabetes in pakistan has risen dramatically. there will be 33 million diabetic adults in pakistan in 2021, a 70% rise from 2019. after china (with 141 million cases) and india (with 102 million), pakistan presently has the third-highest rate of diabetes prevalence worldwide (74 million). the growth in the prevalence of type 2 diabetes can be attributed to multiple variables, including but not limited to those in the areas of economics, demography, ecology, and heredity. urbanization, an ageing population, a decline in physical activity, and a rise in overweight and obesity are all contributing factors. in addition to providing useful information for larger-scale diabetes initiatives at the national and provincial levels (and their partners), this study's unique emphasis on the patient's point of view could be seen as groundbreaking (as an illness). the recommended treatment will be interpreted from patient's viewpoint and their respective issues, concerns, challenges and socio-cultural elements at large that may influence or compromise the adherence towards the proposed treatment of diabetes. therefore, from the patient's vantage point, the proposed treatment's implementation through pilot intervention in chosen health facilities can be understood as an explanatory model of sickness (of/for diabetes).

Eligibility criteria:
inclusion criteria: * people between the ages of 30 and 50 * sedentary professions, such as teachers and bankers, it experts, doctors, administrative job personal * working for the past 03 years . exclusion criteria: * disabled people who cannot move or engage in an active lifestyle . * those individuals already diagnosed with mental health issues

Keywords: sedentary professionals lifestyle practices lifestyle medicine medical anthropology
nimotuzumab in combination with chemoradiation for esophageal cancer

Conditions: Advanced Esophageal

Summary: nimotuzumab (hr3) is an igg1 humanized monoclonal antibody that recognized an epitope located in the extra cellular domain of the human epidermal growth factor receptor (egfr). clinical efficacy has been shown in adult with head and neck cancer. the phase i study assessed the safety, and efficacy of the combination of nimotuzumab administered concomitantly with chemo-radiotherapy in patients with locally advanced esophageal cancer tumours.


Eligibility criteria:
inclusion criteria: * informed consent form signed before performing any of the study's specific procedures. * ecog performance status 0-2. * age \> 18 and \< 75. * measurable disease by response evaluation criteria in solid tumors (recist) criteria, greater than or equal to 1 cm (longest diameter) by spiral computed tomography (ct) scan and mri or greater than or equal to 2 cm by other ordinary radiographic technique. * histologically confirmed diagnosis of locally advanced esophageal. * life expectancy of more than 3 months. * use of an effective contraceptive method for patients of both sexes when there is a risk of conception and/or pregnancy. * no serious blood producing,abnormal function of heart,lung, liver, or kidney or immuno-deficiency * neutrophils ≥3×109/l, platelet count≥100×109/l and haemoglobin≥9g/dl ,creatinine ≤ 1.5 x nul exclusion criteria: * previous radiotherapy or chemotherapy * pregnant or breast-feeding women * drug abuse, unhealthy drug/alcohol addiction,or virus (hiv) infection * evidence of distant metastasis * participation in other clinical trials * patients with aphthosis, complete obstruction, fistula or deep peptic ulcer in the esophagus, or haematemesis * uncontrolled psychiatric disease or seizure * patients not fit for the clinical trial judged by the investigators

Keywords: nimotuzumab esophageal chemo-radiotherapy
mental health and vigorous-intensity physical activity

Conditions: Mental Health Issue

Summary: twenty-five percent of the population worldwide will experience a severe mental illness during their lifetime (world health organization, 2017). these people present strong barriers to adhering to moderate and vigorous-intensity continuous training. it is fundamental to overcome these barriers for practicing moderate-to-vigorous physical activity by adding behavioural change techniques into physical activity interventions (maurus et al., 2023), in order to design and implement sustainable interventions that empower people to engage in it. the main objective of this protocol is to evaluate the impact of a moderate-to-vigorous physical activity program on improving clinical, functional and personal recovery outcomes in order to seek for a diverse array of improvements in mental, physical health, quality of life and functioning in people who have severe mental illness

multi-centric, controlled clinical trial. data will be collected from recuperation services from central catalonia. a sample size of 80 people will be allocated into a control group (n=40) or intervention group (n=40), with post-intervention follow-up at 7 and 10 months. professionals from recuperation services will explain the physical activity program to everyone included, and they will invite them to participate through a specific interview guide. the control group will receive usual healthcare from their recuperation service. the intervention group will participate in a 7-month vigorous-intensity physical activity program which pretends to increase the number of physical activity daily bouts.

Eligibility criteria:
inclusion criteria: * severe mental illness diagnosis, according to the 5th edition of the diagnostic and statistical manual of mental disorders (dsm-5) * volunteers to engage in a physical activity program. exclusion criteria: * decompensation of the underlying disorder * have absolute contraindications due to the practice of physical exercise * have lack of understanding of the catalan or spanish language.

Keywords: vigorous-intensity physical activity fitness sedentary behavior severe mental illness mental health rehabilitation services
efficacy and safety of a continent cutaneous urinary diversion in spinal cord injury patients

Conditions: Spinal Cord Injuries; Urinary Diversion; Neurogenic Bladder

Summary: continent cutaneous urinary deviation (cud), using the mitrofanoff, yang-monti or casale principle, is offered to patients with neurological diseases who are unable to perform intermittent catheterisation through the native urethra due to upper limb disability. there is very little data in the literature examining the long-term efficacy and complications of this technique. the main objective of this study is to evaluate the effectiveness of long-term cuds in spinal cord injury patients. the secondary objectives are to evaluate the surgical complications and the impact on the patient's quality of life. for each patient, several data will be collected and analyzed: age at operation, sex, body mass index (bmi), asa score, asia score, type of bladder dysfunction assessed by urodynamic evaluation, urinary abnormalities assessed by morphological examination (ultrasound and / or computed tomography) and cystoscopy, creatinine clearance, operative indications, initial mictional mode, surgical assembly and any immediate or late complications. in a second stage, a questionnaire survey will be conducted by telephone.


Eligibility criteria:
inclusion criteria: specific inclusion criteria for the study : * no history of continuous cystostomy in another centre * a follow-up \> 24 months, * a continent cutaneous urinary diversion for a spinal cord injury. general inclusion criteria : * patient affiliated to or beneficiary of a health insurance scheme. * adult patient (≥18 years of age) and under 85 years of age. exclusion criteria: * criteria for non-inclusion specific to the study : * all urinary incontinence outside of medullary waiting period. * a history of continuous cystostomy in another centre. * a follow-up of less than 24 months, * a continent cutaneous urinary diversion for a neurological pathology other than spinal cord injury. general criteria for non-inclusion : * patient in a period of exclusion determined by another study. * patient for whom it is impossible to give enlightened information. * patient under legal protection, guardianship or curatorship. * patient unable to express consent

Keywords: intermittent catheterization mitrofanoff yang-monti
a study of preferences for the first-line treatment of advanced/metastatic non-small cell lung cancer

Conditions: Carcinoma, Non-Small-Cell Lung

Summary: the purpose of this observational study is to determine participants' preferences for outcomes associated with first-line treatment of advanced/metastatic non-small cell lung cancer (nsclc) using a discrete-choice experiment (dce).


Eligibility criteria:
inclusion criteria: the following is the inclusion criteria for pretest interviews and final online survey. participants: * must be 18 years of age or older * must be a us resident. * lung cancer participants with a physician diagnosis of nsclc. global perspectives will be involved to suggest alternative strategies to a physician-confirmed diagnosis to ensure that actual cancer participants are recruited. exclusion criteria: * not applicable other protocol-defined inclusion/exclusion criteria apply

Keywords: preference advanced/metastatic nsclc discrete choice experiment (dce)
multidisciplinary management of hcc in elderly patients

Conditions: HCC; Quality of Life

Summary: aim of this study is to evaluate whether treating hcc recurrences in resected elderly patients is advantageous or not.

introduction- hepatocellular carcinoma (hcc) is the most common primary liver malignancy. it usually develops in cirrhotic liver with high recurrence rates. more than 2/3 of patients are elderly, often excluded from surgery and follow-up protocols. aim of this study is to evaluate whether treating hcc recurrences in resected elderly patients is advantageous or not. materials and methods- 126 patients, aged between 65 and 90 years, submitted to liver resection for hcc were enrolled. they were divided into three classes. class 1 included patients submitted to major resections, class 2 to minor resections and class 3 to minor resections associated with thermoablation. all of them were clinically and radiologically followed up. patients who developed recurrences (group a) were referred to further treatments (surgery, interventional radiology or pharmacological therapy). mortality, disease-free survival (dfs), overall survival (os) and quality of life (qol) were evaluated and compared with non-recurrent patients (group b). used interventional radiology means were radiofrequency ablation (rf), microwaves ablation (mwa) or transcatheter arterial chemoembolization (tace).

Eligibility criteria:
inclusion criteria: * hcc patient * eligible for surgery exclusion criteria: * non eligible for surgery at first hcc diagnosis

Keywords: hcc hcc in elderly recurrent hcc liver resection quality of life intervention radiology rf tace
reveal iii: risk evaluation and education for alzheimer's disease

Conditions: Alzheimer Disease

Summary: the purpose of this study is to provide healthy adults with genetic testing and information about their chances of developing alzheimer's disease.

alzheimer's disease is a common condition affecting memory and thinking. genes can sometimes be used to provide risk estimates for the eventual development of certain common diseases. apolipoprotein e (apoe) is one gene that has been identified which can provide information about a person's chances of developing alzheimer's diseases. previous research explored the behavioral and psychological impact of receiving genetic risk information for alzheimer's disease (ad). the reveal i study, funded in 1999, showed that an alzheimer's disease genetic risk assessment can be given to relatives of people with ad in a safe way. reveal ii, which was funded in 2003, demonstrated that this same information can be given in a condensed education and counseling protocol without causing severe psychological harm. reveal iii will further study different ways of providing genetic risk information for alzheimer's disease. participation in this study will entail an initial screening phone call to determine eligibility, followed by a phone interview which will ask about demographic information and thoughts and feelings about ad. participants will complete a mailed survey. following completion of the survey, a genetic counselor will meet with the participant at the clinic to review family and medical history, administer additional questionnaires asking about ad and genetic testing, and draw blood for genetic testing. results will be disclosed either in person or over the phone about 3 to 4 weeks later. the genetic counselor will make a brief follow-up phone call 1 week after that. the participant will visit the clinic twice to provide additional information, at 6 weeks and 6 months after disclosure. finally, the participant will complete a mailed 12 month survey, and the genetic counselor will make a brief follow-up phone call.

Eligibility criteria:
inclusion criteria: * aged 18 years to 85 years old exclusion criteria: * unable to visit a study site * current untreated depression or anxiety * family history of ad diagnosed under age 60 * more than one first-degree relative diagnosed with ad (e.g. mother and brother)

Keywords: disease /disorder proneness /risk family genetics genetic counseling genetic marker genetic polymorphism genetic screening genetic susceptibility
the ddi study of sp2086 and valsartan

Conditions: Type 2 Diabetes

Summary: the purpose of the study is to investigate the potential pk interaction between sp2086 and valsartan after multiple oral doses treatment in healthy male volunteers.


Eligibility criteria:
inclusion criteria: * healthy volunteers with a body mass index (bmi, a measure of a person's weight in relation to height) between 19 and 26 kg/m2. exclusion criteria: * history of diabetes * history of heart failure or renal insufficiency * urinary tract infections, or vulvovaginal mycotic infections * history of or current clinically significant medical illness as determined by the investigator * history of clinically significant allergies, especially known hypersensitivity or intolerance to lactose * known allergy to sp2086 or valsartan or any of the excipients of the formulation of sp2086 or valsartan
effect of a simulated flight in patients with type 2 diabetes and healthy volunteers

Conditions: Type 2 Diabetes

Summary: diabetes is an increasingly common condition which affects millions of people in the united kingdom. patients with type 2 diabetes are at increased risk to develop severe heart disease and vascular complications and these can result in death. a cornerstone of the treatment is lifestyle and diet. the number of travellers is increasing quickly and there are more people than ever travelling by airplane. during a commercial flight the pressure of the air is lower than the pressure on the surface and that results in lower concentration of oxygen in the air we are breathing while flying. also the humidity is very low inside an aircraft. the aims of this study are to show if we can use a simulated flight as a method to look at how the endothelial cells react and to see if this is different between patients with type 2 diabetes mellitus and healthy volunteers. a sub-study is also incorporated to look at different dietary interventions in type 2 diabetes.


Eligibility criteria:
inclusion criteria: diabetes group: * diagnosis of type 2 diabetes * patients on stable medication (for their diabetes metformin being the only treatment if any), for 3 months prior to entry into the study * age between 45-75 years at the start of the study; women need to be postmenopausal and not undergoing hormone replacement therapy (hrt) healthy volunteers group: * no current disease or medication which would have effect on the safety of the subjects or interfere with the study results * age between 45-75 years at the start of the study; women need to be postmenopausal and not undergoing hrt exclusion criteria: * for both groups: * patients with concurrent illness or any medication in the last 3 months that would interfere with the study based on the investigator's judgement * acute coronary syndrome in the last 3 months or any major clinical event in the previous 3 months that would effect the study based on the investigator's judgement * patients not wishing to allow disclosure to their general practitioner (gp)s. * hba1c \>9% * smokers * pre-menopausal women or post-menopausal women on hrt * claustrophobia, panic attacks in the anamnesis * subjects must not have been subjected to a commercial flight within 4 weeks of the study
personalized treatment for patients with premature ventricular beats

Conditions: Ventricular Premature Complexes

Summary: frequent premature ventricular beats (pvbs) are common, negatively affects the quality of life for many patients, and can lead to impaired contractile function. rule-out of structural heart disease is key in the assessment of pvbs. cardiac mr has a high sensitivity for structural heart disease, but the diagnostic gain from this resource-demanding procedure in the work-up of patients with pvbs is unknown. there is a need to establish the role of mr in the evaluation of patients with pvbs to improve diagnostic efficacy, establish treatment strategies, and promote further research. this project will answer three key questions: 1) what is the diagnostic gain from cardiac mr in patients with pvbs? 2) is mr the real gold standard to rule-out structural heart disease in patients with pvbs? 3) can non-invasive heart rate parameters guide the strategy for induction of pvbs during invasive electrophysiological procedures?


Eligibility criteria:
inclusion criteria: patients referred for pvc ablation