Kornimate/medical-research-clean huggingface dataset:
association of urinary incontinence with depression, insomnia, frailty and falls in older adults

Conditions: Urinary Incontinence,Stress; Urinary Incontinence, Urge; Depressive Disorder; Insomnia; Frailty; Fall

Summary: the aim of our study is to provide a holistic analysis of the geriatric syndromes associated with urinary incontinence, which can result in significant adverse outcomes in the elderly, and to explore the gender-specific relationships within these associations. the study revealed that urinary incontinence is highly prevalent among the older adults, particularly in women, and is associated strongly with depression, insomnia, frailty, and falls. moreover, while older women with urinary incontinence exhibited more depressive symptoms than men, urinary incontinence was associated with similar frequencies of insomnia in both sexes. considering the negative outcomes of depression, insomnia, frailty, and falls in older adults, as well as a decline in functionality, cognitive impairment, and prolonged hospitalizations and even mortality they cause, it becomes evident that urinary incontinence must be routinely assessed and treated by clinicians.


Eligibility criteria:
inclusion criteria: * the patients with comprehensive geriatric assessment data exclusion criteria: * dementia, * those who experienced cerebrovascular occlusion with resulting neuromuscular paralysis * active infections, * schizoaffective disorder, * epilepsy * neuromuscular disorders * those who were wheelchair or bed-bound, * advanced chronic obstructive pulmonary disease (copd) * advanced chronic heart failure (chf)
kt on low back pain patients

Conditions: Low Back Pain

Summary: this study aim evaluates the effect of kinesio taping (kt) on back muscle fatigue of low back pain patients, analysing the electromyography activity of longissimus muscle (median frequency) and the sustained time during a fatigue test (ito test).

individuals with low back pain usually have poor back muscles endurance, which may be improved with the application of kinesio taping. the aim of this study is evaluate the effect of kinesio taping on back muscle fatigue of low back pain patients. sixty-four women, between 18 to 50 years old, with chronic nonspecific low back pain will attend this study. they will be randomly assigned in four different groups: control group (cg), kt with tension group (ktt), kt no tension group (ktnt) and micropore® group (mp) and submitted to three evaluations: pre, three and ten days after intervention, analysing the electromyography activity of longissimus muscle and the sustained time during a fatigue test. the variables analysed during the evaluations will be median frequency (mp) slope of longuissimus muscle and sustained time during the ito test.

Eligibility criteria:
inclusion criteria: * female between 18 and 50 years of age with chronic nonspecific low back pain for more than three months. exclusion criteria: * serious spinal pathologies (fractures, tumors, and inflammatory pathologies such as ankylosing spondylitis); * nerve root compromise (disc herniation and spondylolisthesis with neurological compromise, spinal stenosis, and others); * fibromyalgia * corticosteroid treatment in the previous two weeks; * antiinflammatory treatment in the previous 24 hours; * contraindications to the use of kinesio taping (allergy or intolerance); * score of two or less on visual analogue scale of the first day; * pregnancy; * previous kinesio tape therapy on lumbar.

Keywords: bandage low back pain muscle fatigue electromyography
feasibility study of take-home laam medication - 3

Conditions: Opioid-Related Disorders

Summary: the purpose of this study is to test therapeutic benefits of take-home laam. (1) do subjects with take-home laam availability show increased clinical responsibility over subjects without; (2) do subjects with take-home laam attempt diversion when random recall and other diversion safeguards are used; (3) does treatment response correlate with background or drug use variables at intake, discharge, or during treatment?

1-year study, participant will be randomly assigned to one of two groups: one will have the opportunity to earn take-home doses by turning in a designated number of clean urines. two will not have the opportunity to earn take-home doses. clinic visits three times per week. urine sample given at each visit.

Eligibility criteria:
inclusion criteria: meets dsm-iv criteria for opiate dependence. m/f, 18 years or older. certified for laam treatment by a physician. able to understand english. willing to provide names, addresses, and numbers of 3 relatives who can aid in patient location for follow-up visits. exclusion criteria: hypertensive to laam. pregnant or nursing women. female of childbearing potential who refuses to use an acceptable form of birth control. clinically significant abnormality in hematology, blood work, or ua, etoh and/or sedative/hypnotic dependence according to dsm-iv criteria. medical or psychiatric illness which would jeopardize safe study participation.

Keywords: opiate dependence
a study of dabrafenib plus cetuximab/panitumumab with folfox in the first line of therapy in people with metastatic colorectal cancer

Conditions: Neoplasms

Summary: the purpose of this study is to evaluate the efficacy and toxicity of folfox regimen with dabrafenib and cetuximab/panitumumab in the first line of therapy for the potential treatment of colorectal cancer that: has a metastatic, inoperable; has a mutation in the braf gene and mss. participants in this study will receive one of the following study treatments: these participants will receive folfox regimen with dabrafenib and cetuximab or panitumumab in the first line of therapy this study is currently enrolling participants who will receive either folfox regimen with dabrafenib and cetuximab or panitumumab in the first line of therapy. the study team will monitor how each participant responds to the study treatment for up to about 3 years.

the purpose of the study is to evaluate the efficacy and toxicity of first-line folfox with dabrafenib and cetuximab or panitumumab in patients with previously untreated metastatic inoperable colorectal cancer who have mss and braf mutation.

Eligibility criteria:
inclusion criteria: * histologically confirmed colorectal adenocarcinoma that contains mss and braf v600e mutation * metastatic inoperable colorectal cancer * adequate function of hematopoiesis and basic indicators of internal organs * has measurable or evaluable disease according to response evaluation criteria in solid tumors (recist v1.1). * lacking antitumor systemic treatment for colorectal cancer. * patients with progression after adjuvant chemotherapy may be included if progression is recorded no earlier than 12 months after the last course of chemotherapy. * the primary tumor is removed or asymptomatic. * absence of grade 2 or higher neuropathy. * absence of tumor msi or dmmr. * ecog ps 0-2 exclusion criteria: * participants having more than 2 lines of treatment (a progression of disease within 12 months of the completion of adjuvant and/or perioperative chemotherapy with oxaliplatin and fluoropyrimidines is acceptable). * presence of any other malignancy, except radically treated basal cell carcinoma, cervical cancer in situ, currently or within 5 years prior to enrolment. * pregnant and breastfeeding women. * male and female patients with preserved reproductive potential who refused to use adequate contraception throughout the study. * hiv-infected patients. * patients with a life expectancy of less than 3 months. * the presence of a disease or condition that, in the opinion of the investigator, prevents the patient from participating in the trial.

Keywords: metastatic colorectal cancer braf v600e- mutated first line mss treatment
assessment of distal limbs fractures with cone-beam ct newtom 5g

Conditions: Distal Limbs Bones Fractures

Summary: conebeam scanner (cbct) is a widely technique used for dental and maxillofacial imaging. patients can be set up in a sitting or a laying position in the, newtom 5g cbct allowing for an analysis of the distal appendicular skeleton. the investigators' hypothesis is that the cone-beam scanner could detect and characterize fractures of the extremities similarly to a multidetector ct (mdct). 150 patients over 18 years requiring a ct scan for a suspected distal limb fracture or a preoperative assessment will be enrolled. the primary endpointis based on the ability of cone-beam scanner to properly characterize the type of fracture using a classification derived from maurice e. müller (ao) classification. secondary endpoints will concern the depiction of the fracture, the assessment of the soft tissues near the fracture, quality of images, inter and intra-operator reproducibility and tolerance of the patient for the examination. patients will have a mdct considered as the reference exam, then a cbct. exams will be anonymized and read twice by two trained radiologists with 3-6 week intervals. the inter-observer agreement for the diagnosis of fracture type between the two techniques will be evaluated by a kappa coefficient. the evaluation of diagnostic performance will be achieved by studying the sensitivity, specificity, negative predictive value and positive predictive value, and its likelihood ratio. kappa test will be performed to evaluate the consistency of the characterization of the fracture and the evaluation of soft tissue near the fracture. a student t test will be performed for paired data if distributions are normal, a wilcoxon test if not. to assess patient's tolerance, the percentages of (painful, not painful) will be calculated for each technique and will be compared using the chi2 test (or fisher's exact test if the chi can not apply).


Eligibility criteria:
inclusion criteria: * patient age 18 years old or above, weight ≤ 160 kg * patient require mdct for a suspected distal limb fracture or a preoperative assessment * french spoken an read * free and informed consent signed * being affiliated to a french social security system or similar. exclusion criteria: * patients already included in the study for a previous fracture * patient with severe pain and reduced spontaneous mobility that could prevent proper positioning for the cone-beam * lack of effective contraception (risk of pregnancy) or pregnancy proven data on interrogations * patient on protection of the court, under supervision or trusteeship * inability to express a consent * patients already enrolled in a study with a conflict of interest with this study. * the presence of osteosynthesis materiel or capital may interfere with image quality. a sample of 3 to 5 patients may be included at the beginning of the study to test the image quality in presence of material.

Keywords: distal limbs fracture, acute trauma, imaging, cone beam computed tomography,
effect of extracorporeal shock wave combined with autologous platelet-rich plasma injection on rotator cuff calcific tendinitis

Conditions: Rotator Cuff Tendinitis; Rotator Cuff Tendinosis

Summary: the purpose of this study is to explore the effect of extracorporeal shock wave combined with autologous platelet-rich plasma injection on the rehabilitation of rotator cuff calcific tendinitis, to provide new treatment methods and evidence for the rehabilitation of rotator cuff calcific tendinitis, and to reduce patients; pain and return to normal life as soon as possible.

the purpose of this study is to explore the effect of extracorporeal shock wave combined with autologous platelet-rich plasma injection on the rehabilitation of rotator cuff calcific tendinitis, to provide new treatment methods and evidence for the rehabilitation of rotator cuff calcific tendinitis, and to reduce patients\&#39; pain and return to normal life as soon as possible.

Eligibility criteria:
inclusion criteria: * meet the diagnostic criteria for rotator cuff calcific tendonitis, aged between 40 and 60 years old * persistent pain in the affected shoulder, with obvious tenderness under the acromion and rotator cuff, as confirmed by x-ray and computed tomography (ct) and magnetic resonance imaging (mri) examination showed one or more round-shaped high-density calcium salt deposits near the greater tuberosity of the humerus * all were diagnosed for the first time * complaints of severe pain in the shoulder joint, obvious exclusion criteria: * combined with rotator cuff trauma, long head of biceps tendonitis and other shoulder joint diseases * past combined history of shoulder joint surgery * patients with internal fixation of the shoulder joint * shoulder joint combined with infection, tumors and other lesions * combined with severe heart, liver, and kidney dysfunction * do not agree to participate in the study or fail to sign the informed consent form.

Keywords: rotator cuff calcifying tendinitis prp esw
based on the ultrasound evaluating the effect of xiaozhong fang particles for knee osteoarthritic with synovial fluid

Conditions: Knee Osteoarthritis

Summary: this study is a randomized, single blind, controlled trial. aim to compare the effectiveness (especially the absorption degree of the synovial effusion measured by b ultrasonic) of the treatment group with the control group. the treatment group was given xiao zhong fang granules orally and short wave infrared radiation and the control group was given the placebo xiao zhong fang granules orally and short wave infrared radiation. to evaluate the clinical efficacy of the chinese medicine in the treatment of the synovial effusion of knee osteoarthritis.


Eligibility criteria:
inclusion criteria: * 1) the american society of rheumatology established the diagnostic criteria for knee oa in 2001; * 2) kellgren/lawrence score of knee joint grade as i,ii and early iii. * 3) according to "principles of clinical guidance for new drugs of traditional chinese medicine ",diagnosed as "xi bi disease". * 4) patients with informed consent. * 5)blood and urine routine tests, liver and kidney functions, electrocardiogram were normal before recruitment. * 6) patients were not treated with nsaids drugs or hormone drugs, and no patients were treated with drugs related to this disease at least 2 weeks. exclusion criteria: * 1)patients suffer from other rheumatic and metabolic diseases such as gout, rheumatoid arthritis, diabetes and so on. * 2) patients with knee joint inflammatory infection, such as suppurative and nonspecific. * 3)patients accompanied by traumatic synovitis, villonodular pigmented synovitis, synovial membrane of the knee is the main lesion. * 4) patients with informed consent. * 5)the color of joint fluid of patients' knees is pink or other color or cloudy; the white blood cell counts \> 1000 /mm3 or with crystal in the joint fluid. * 6)patients blood rf \> 30iu/ml, esr \> 20mm/h, crp \> 10mg/l. * 7)patients combined with severe cardiovascular, cerebrovascular, liver, kidney and other primary diseases and mental diseases.

Keywords: knee osteoarthritis synovium effusion rct placebo
food and the brain

Conditions: Binge Eating

Summary: the proposed study will examine the role of reward and emotion in women with and without a history of binge eating. it is important to understand how the brain responds to reward and emotion in binge eating in order to identify different pathways toward binge eating and provide individualized targets for treatment. this is particularly important in light of the fact that for many patients, the current treatments for binge eating are not effective.


Eligibility criteria:
inclusion criteria: * female * ages 18-35 * with or without current binge eating behaviors exclusion criteria: * any contraindication for mri (orthodontia, vascular stents, metallic ear tubes, metal implants, piercings, etc). * substance abuse * traumatic brain injury * bmi \< 18.5 * pregnant women

Keywords: fmri emotion conflict task monetary incentive delay
improving trans-oral surgical outcomes through intra-operative image guidance

Conditions: Oropharyngeal Cancer

Summary: the objective of this research is to perform a pilot study on patients undergoing laryngoscopy for diagnostic and tumor staging purposes (for pharyngeal or laryngeal cancer) in which intraoperative ct imaging will be performed both prior to (but after induction of general endotracheal anesthesia) and during placement of the laryngoscope in order to better understand anatomic changes that occur during instrumentation of the oral cavity and oropharynx. the goals of the study are: 1. develop a suite of de-identified images and surface renderings that qualitatively show how a tumor and the upper aerodigestive tract anatomy deform during a laryngoscopic evaluation. 2. create deformation models of the upper aerodigestive tract. this data to be used for future retractor development as well as for virtual image guided surgery.


Eligibility criteria:
inclusion criteria: * adult patients (\>18 years) seen in the head and neck tumor clinic who will require laryngoscopy in the operating room for diagnosis and staging of known or suspected tumors of the upper aerodigestive tract. exclusion criteria: * patients who are unable to tolerate general anesthesia. * patients who are felt to be a "difficult airway" for induction of general endotracheal anesthesia. * patients with excessive dental restorations and amalgam.
effect of thiamin supplementation on thiamin status in children with heart disease receiving diuretic drugs

Conditions: Heart Diseases

Summary: the purpose of this study is to determine effect of thiamin supplementation on thiamin status by measuring thiamin pyrophosphate effect in children with heart disease receiving diuretic drugs.

children with heart disease receiving diuretic drugs are susceptible to thiamin deficiency due to increase renal loss. thiamin deficiency causes abnormal cardiac contraction resulting in heart failure.

Eligibility criteria:
inclusion criteria: * children aged 1 month old to 15 years old diagnosed as heart disease * receiving diuretic drugs at least 1 month exclusion criteria: * receiving thiamin-containing vitamins * receiving hemodialysis or peritoneal dialysis * having problems of intestinal malabsorption, chronic lung disease, red blood cell abnormality such as thalassemia , abnormal hemoglobin typing, g6pd deficiency * receiving thiamin-producing probiotics * receiving inotropic drugs * severe anemia: hb \< 7 g/dl

Keywords: diuretic drugs thiamin deficiency
short course radiation therapy in palliative treatment

Conditions: Palliative Care

Summary: the study wants to define the maximum tolerated dose (mtd), safety and efficacy of a short course radiation treatment in patients with symptomatic advanced head and neck cancer.

the study wants to define the maximum tolerated dose (mtd) of a conformal short course accelerated radiation therapy delivered in twice daily fractions and 2 consecutive days, and the feasibility of this fractionation in term of safety and efficacy for symptomatic palliation of metastatic or locally advanced head and neck cancer.

Eligibility criteria:
inclusion criteria: * histologically proven locally advanced or metastatic h\&n cancer * excluded from curative therapy because of disease stage and/or presence of multiple comorbidities and/or poor performance status * age \> 18 years * eastern cooperative oncology group (ecog) performance status \< 3 exclusion criteria: * prior rt to the same region.

Keywords: palliative care head and neck cancer radiotherapy pain quality of life
the role of igf-1 generation test in diagnosis and treatment of short stature

Conditions: Short Stature

Summary: the purpose of the study is to evaluate the predictive value of igf-1 generation test for growth velocity during gh treatment for 12 months.


Eligibility criteria:
inclusion criteria: * ability to provide written informed consent * prepubertal males and females form 5- 11years old * bone age \<11 years in males and \<9 years in females * height sd score\<-2.25sd in males and females * igf-1sd score \<-1sd in both males and females * peak gh level after stimulation \>10ng/ml exclusion criteria: * history of prior chemotherapy and or radiation * active neoplasm * pediatric patients with closed epiphyses * prader-willi syndrome, turner syndrome or any other genetic or chromosomal anomaly * treatment with inhaled or systemic steroids * bmi \ 95th percentile * tanner 2 at clinical or biochemical examination by ultrasensitive lh and fsh

Keywords: igf-1 short stature gh
remote ischemic conditioning on cerebral small vessel disease

Conditions: Cerebral Small Vessel Diseases

Summary: this trial is a randomized, controlled, single-center, double-blind trial. cerebral small vessel disease (csvd) patients will be recruited and randomized into ric or control group.the protective effect of remote ischemic conditioning (ric) on csvd will be investigated.


Eligibility criteria:
inclusion criteria: 1. 45-80 years old, and gender not limited; 2. patient and/or caregiver report of cognitive declines with regard to memory and/or other cognitive domains lasting for at least 3 months; 3. neither normal nor demented on the basis of the criteria of the diagnostic and statistical manual of mental disorders (fourth edition) with normal or slightly impaired activities of daily living9, with mini-mental state examination (mmse) score ≥ 20 (primary school) or ≥ 24 (junior school or above)10 and montreal cognitive assessment (moca) score ≤ 26; 4. the presence of lacunes and/or wmhs and/or cmbs on mri 5. absence of vascular narrowing \>50% luminal diameter that could cause hemodynamic changes (mfv\>90 cm/s for the intracranial internal carotid artery, 100 cm/s for mca, \>80 cm/s for basilar artery \[ba\] or vertebral artery) measured by tcd exclusion criteria: 1. clinical manifestations indicating that the patient was at the end-stage of csvd; 2. hereditary or inflammatory small vessel disorders 3. cerebral venous injury or changes; 4. diagnosis of nervous system degenerative diseases alzheimer's disease, dlb, frontotemporal dementia (ftd), and so on; 5. history of intracranial hemorrhage or significant bleeding in other parts of the body 6. brain tumor, psychoses, or acute stroke within 6 months; 7. cardiogenic embolism; 8. significant bleeding coagulation dysfunction; 9. serious liver and kidney function is not complete, malignant tumor, or serious diseases need to medical intervention or surgery; 10. any soft tissue or vascular injury, and any disease of the extremities that may contraindicate ric; 11. pregnant women; 12. life expectancy\<6 months; 13. refused to sign a consent form, poor compliance, or not to cooperate to complete whole treatment, and so on.

Keywords: cerebral small vessel diseases remote ischemic conditioning