Kornimate/medical-research-clean huggingface dataset:
effect of diacylglycerol oil on risk factors of type 2 diabetes and complicating disease, and mechanism

Conditions: Insulin Sensitivity; Type 2 Diabetes; Cardiovascular Disease

Summary: diacylglycerol oil has been shown to lower postprandial and fasting serum triacylglycerol levels and reduce body fat. the investigators hypothesize that replacing dietary fat with diacylglycerol oil reduces excess body fat in type 2 diabetic patients and that diacylglycerol oil has a beneficial effect on cardiovascular risk factors in chinese type 2 diabetic patients.


Eligibility criteria:
inclusion criteria: 1. type 2 diabetic patients, blood sugar levels were stabilized between 7.0-10.0 mmol/l 2. male, aged 40 - 70 years old, female, aged post-menopausal - 70 years old. 3. overweight/obese patients (bmi 25 - 40 kg/m2) 4. currently under diet therapy for diabetes mellitus 5. understands the procedures and willing to participate in the study exclusion criteria: 1. patients who unwilling to give informed consent 2. type 1 diabetic patients 3. familial hyperlipemia patients or blood triacylglycerol concentration \> 400 mg/dl 4. patients with a history of cardiovascular disease and/or arteriosclerotic disease 5. patients with a history of cerebrovascular disease 6. patients with serious hepatic disease and/or renal disease 7. patients with malignancy 8. participation in another clinical study within 30 days prior to screening period. 9. has a condition the doctor in charge believes would interfere with evaluation of the subject, or may put subject at undue risk

Keywords: diacylglycerol oil insulin sensitivity type 2 diabetes cardiovascular disease risk factors
translation of neck disability index into local pakistani languages of pakistan

Conditions: Neck Pain

Summary: the aim of the study is to translate the neck disability index (ndi) questionnaire into pushto, punjabi, sindhi and balochi versions and o test the validity \& reliability of translated versions of ndi among neck pain patients in pakistan.

the neck disability index is a state-unambiguous instrument for the description of a disability. it is revised from the oswestry low back pain questionnaire it contains 10 items mentioning various activities (personal care, lifting, driving, work, sleeping, concentration, reading, recreation) and pain (pain intensity, headache) with 6 conceivable answers for each item. patients are educated to choose only one answer which most closely suits their condition at the current time. the score of each item ranges between 0 (no pain and no functional limitation) and 5 (worst pain and maximal limitation) that lead to the total score of 0 (no disability) to 50 (totally disabled), as 0-4 points (no disability), 5-14 points (10-28% disability), 15-24 points (30-48% disability), 25-34 points (50-64% disability) and 35-50 points (70-100% disability). the meantime to fill the questionnaire is 3-7.8 minutes. the ndi showed high validity and reliability for patients with neck pain. by this study, the accuracy and reproducibility of the translated versions of ndi questionnaires will be enhanced and thus can create a useful measure to obtain data from culturally/linguistically diverse people belonging to different ethnic background as in pakistan. it will create trustworthiness among clinicians and researchers to utilize the tool as a measure of what it is supposed to measure.

Eligibility criteria:
inclusion criteria: * mechanical neck pain * participants belonging to urdu, pushto, punjabi, sindhi and balochi speaking class * participants from inpatient and outpatient department of hospitals * participants should complete the questionnaire in their respective language without the help exclusion criteria: * healthy individuals * pathological neck pain * traumatic cervical or neck injuries * participants with disability due to any structural/ congenital cause

Keywords: neck pain neck disability index tool translation
ventricular reversed remodeling after ltx in pah patients

Conditions: Pulmonary Arterial Hypertension

Summary: the investigators will evaluate ventricular reversed remodelling after double lung transplantation (ltx) in patients with pulmonary arterial hypertension (pah), measured with cardiac magnetic resonance imaging (mri). reversed remodelling will be compared with control patients without pah (e.g. cystic fibrosis) who will also undergo ltx.

in this study, pre-ltx and six-months post-ltx measurements will be compared with each other and between the primary and control group. pre- and post-ltx measurements include: past medical history: including basic diagnosis; interventions, surgery and transplant related complications (re-operations, hospitalizations, infections) and medication history; these data will be collected by studying the medical files including surgical reports. present medical history: including nyha class. physical examination: including length and weight. cardiac magnetic resonance imaging: * ventricular volume, function and mass measurements * flow measurements of the pulmonary artery and aorta * disease specific measurements (e.g. septal bowing, rv trabecularisation, etc.) * t1-mapping transthoracic echocardiography resting ecg: disease specific electrophysiological findings (e.g. qrs-duration, right bundle branch block). laboratory evaluation: * nt-pro-bnp * egfr * remaining serum will be stored.

Eligibility criteria:
inclusion criteria: * patients who are on the waiting list for double-ltx, in our institution, for pulmonary arterial hypertension. * eligible for cmr imaging * no claustrophobia * no pacemaker, icd, etc. * informed consent exclusion criteria: * inability to comply with primary endpoint measures. * body mass index ≥40 kg/m2. * pregnant patients will not be included, they may be included \>3 months after pregnancy. * patients with age \<18 years.

Keywords: pulmonary arterial hypertension lung transplantation mri
observational study of the conjugated rehabilitation on children with cerebral palsy

Conditions: Cerebral Palsy

Summary: this study is designed to assess effectiveness, safety and cost-utility of conventional rehabilitation and traditional korean medicine conjugated rehabilitation on children with cerebral palsy.

1. survey 1. an interview survey on baseline * basic characteristics * cause of cerebral palsy * accompanied disorders * health problems * operation history * drug-taking * rehabilitation treatment * korean medicine treatment * health functional food * medical care cost 2. an interview survey on 26th and 52nd weeks * accompanied disorders * health problems 3. a weekly tracking survey * health problems * therapeutic change * medical care cost * quality of life 2. assessment for function development on baseline, 26th and 52nd weeks * gross motor function classification system (gmfcs) * gross motor function measure-66 (gmfm-66) * pediatric evaluation of disability inventory (pedi)

Eligibility criteria:
inclusion criteria: * children with cerebral palsy * age from 6 to 78 months * whose guardian consent to the present study exclusion criteria: * who had an orthopedic operation due to cerebral palsy * who has congenital muscular disease, hereditary disease, or progressive central nervous system diseases * who suffers from severe diseases (ie, cancer, severe heart disease, severe infectious disease)

Keywords: cerebral palsy gmfm-66 pedi
observational study for the cytofluorimetric analysis of cerebrospinal fluid in non-hodgkin's lymphoma patients

Conditions: Diffuse Large Cell Lymphoma; Lymphoblastic Lymphoma; Burkitt's Lymphoma

Summary: the purpose of this study is to define if flow cytometry has more sensitivity for detecting neoplastic cells in cerebrospinal fluid versus conventional cytology.

aggressive b-cell non-hodgkin's lymphoma (b-nhl), lymphoblastic lymphoma and burkitt's lymphoma are at high risk of cns relapse. for this reason is recommended a prophylaxis therapy. this suggests that negative leptomeningeal localization patients at diagnosis are really positive and that would be a very high risk of cns relapse subtype patients. it's very important detecting neoplastic cells in cerebrospinal fluid as soon as possible. this study will evaluate only patients that have been flow cytometry and cytology at diagnosis.

Eligibility criteria:
inclusion criteria: 1. diagnosis of * diffuse large cell lymphoma hiv positive, * lymphoblastic lymphoma, * burkitt's lymphoma, * mantle cell lymphoma blastoid type. 2. dlcl patients who presented one risk factor for leptomeningeal involvement as: * testis, bone marrow, orbit, palate, paranasal cavity or peridural disease localization, * 2-3 age-adjusted ipi score with more than 1 extranodal site and ldh \> normal. 3. patients with cytologic and flow cytometry on cerebrospinal fluid at diagnosis. exclusion criteria: 1. patients with clinical or strumental evidence of meningeal localization disease.
efficacy and safety of two different botulinum toxin type a treatments for moderate to severe cervical dystonia

Conditions: Spasmodic Torticollis

Summary: the purpose of this study is to compare two types of botulinum toxin type a to treat the involuntary muscle contractions in the neck


Eligibility criteria:
inclusion criteria: * diagnosed with cervical dystonia/spasmodic torticollis for at least 18 months * successfully treated previously with botulinum toxin type a exclusion criteria: * breast feeding, pregnant, or could become pregnant * surgery or spinal cord stimulation for cervical dystonia * previous injections of phenol, alcohol for cervical dystonia
development of a behavioral team intervention for obsessive compulsive disorder

Conditions: Obsessive Compulsive Disorder

Summary: the overall aim of this study is to determine modifications to exposure and response prevention (erp) therapy that are needed in order to effectively deliver treatment for obsessive compulsive disorder (ocd) in a community mental health center. this study is the final study in a series of three projects executed to adapt and pilot-test a team erp (t-erp) intervention that will optimize therapist time by utilizing paraprofessionals to assist with group-erp treatment plans. the intervention will be tailored to meet the unique needs of low-ses individuals with ocd and be implemented in a community mental health center (cmhc).


Eligibility criteria:
inclusion criteria: 1. 18 years to 65 years 2. english speaking 3. primary dsm-iv ocd (identified by the patient and therapist as the most problematic disorder over the past year) 4. at least moderate severity ocd (ybocs \> 16) 5. not currently on psychotropic medications or on the same psychotropic medications for at least 4 weeks prior to screening 6. have never received 10 or more sessions of erp 7. not currently attending psychotherapy for ocd 8. low-income based on the u.s. housing and urban development (huds) threshold for ri (less than $41,000 per year for individuals). exclusion criteria: 1. significant cognitive impairment (mmse \< 25) 2. prominent suicidal ideation 3. current psychosis, mania, alcohol or drug dependence as assessed by the scid-p. 4. prominent hoarding
changes in blood lipids after long-term consumption of n-3 lc-pufa-enriched dairy products

Conditions: Hypertriglyceridemia

Summary: the study was performed to investigate the effects of n-3 lc-pufa supplemented dairy products cardiovascular risk factors in hypertriglyceridemic patients.

recent studies suggest that n-3 lc-pufa intake might be useful to prevent coronary heart diseases. as a precondition for participating in this study, the patients were provided information in writing and verbally about the details of the study. informed consent was obtained from all volunteers. before the beginning of the study, all participants were subject to a medical examination by their general practitioners. fifty-one hypertriglyceridemic patients (25 f, 26 m; with triacylglyceride (tag) values ≥ 150 mg/dl or ≥ 1.7 mmol/l) entered the study. the placebo-controlled, randomized double-blind cross-over study consisted of two investigation periods of 15 weeks, with a ten-week washout period in between. after the washout period the intervention was crossed between the groups and the respective products were consumed for another 15 weeks. patients received about 40 g fat daily (200 g yoghurt with 3.8% fat, 30 g cheese with about 50% fat in the dry matter, and 20-30 g butter). the milk fat was partially exchanged by special oils (fish oil, rapeseed oil) with high amounts of eicosapentaenoic acid (epa), docosahexaenoic acid (dha), and alpha linolenic acid (ala). the daily dose of n-3 fa amounted to 3.3 g, consisting of 1.5 g epa, 1.2 g dha, 0.2 g dpa, and 0.2 g ala. venous blood and 24h urine were collected at the beginning and at the end of each period.

Eligibility criteria:
inclusion criteria: * tag values ≥ 150 mg/dl or ≥ 1.7 mmol/l exclusion criteria: * blood diluted medications * lipid lowering medications * glucocorticoids * gastrointestinal or metabolic diseases (e.g., diabetes mellitus, hyperthyroidism or hypothyroidism, hypercholesteremic patients with familial previous impacts) * daily alcohol abuse * taking dietary supplements (e. g., fish oil capsules, vitamin e) * known allergies or foodstuff indigestibility

Keywords: n-3 lc-pufa hypertriglyceridemic human tag
preoperative melatonin or vitamin c administration on postoperative analgesia

Conditions: Postoperative Pain

Summary: the investigators designed a randomized double-blind placebo-controlled trial to evaluate the effect of preoperative single dose of oral melatonin and vitamin c administration on postoperative analgesia in patients undergoing elective major abdominal surgery.

the investigators designed a randomized double-blind placebo-controlled trial to evaluate the effect of preoperative single dose of oral melatonin and vitamin c administration on postoperative analgesia in patients undergoing elective major abdominal surgery. one hundred-sixty five asa i-ii adult patients between 18-65 years of age, undergoing elective major abdominal surgery with general anesthesia will be included in this double blinded, randomised, controlled study. patients will randomly divided into equal (n=55) three groups. preoperatively, one hour before surgery, patients will receive melatonin (6 mg) in group m, vitamin c (2 gr) in group c or placebo tablet in group p orally. a standard anesthetic protocol will be administered to all patients. at the end of surgery, postoperative pain control will be provided via a patient controlled analgesia (pca) device including morphine in all groups. hemodynamic parameters, pain, sedation, patient satisfaction, total morphine consumption, supplement analgesic requirement, incidence of nausea and vomiting and other side effects will be recorded at 5, 10, 30 min and 1, 2, 4, 6, 8, 12, 24 hr after surgery.

Eligibility criteria:
inclusion criteria: patients undergoing elective major abdominal surgery with general anesthesia exclusion criteria: a history of psychiatric disorders, chronic pain syndromes, obstructive sleep apnea, severe asthma, chronic obstructive pulmonary disease, congestive heart failure, hepatic or renal failure, patients with pregnancy or in lactation period or a history of allergic reaction to any drugs

Keywords: melatonin vitamin c morphine consumption
rdea3170 and allopurinol combination study in gout subjects

Conditions: Gout

Summary: this is a phase 1b, randomized, open-label, drug-drug interaction study in adult male subjects with gout. it is designed to assess the pharmacokinetics (pk) and pharmacodynamics (pd) of rdea3170 or allopurinol alone and in combination in the fed state.


Eligibility criteria:
inclusion criteria: * subject meets one or more criteria for the diagnosis of gout as per the american rheumatism association criteria for the classification of acute arthritis of primary gout. * subject has a body weight ≥ 50 kg (110 lbs.) and a body mass index ≥ 18 and ≤ 45 kg/m2. * subject has a screening serum urate level ≥ 8 mg/dl and ≤ 10 mg/dl * subject is free of any clinically significant disease or medical condition, per the investigator's judgment. exclusion criteria: * subject is unable to take colchicine for gout flare prophylaxis. * subject has a history or suspicion of kidney stones. * subject has an estimated creatinine clearance \< 60 ml/min calculated by the cockcroft-gault formula using ideal body weight at screening prior to day -2. * subject is on unstable doses of chronic medications. subjects taking medications for chronic medical conditions must be on stable doses during the course of the study, including the screening period. dose adjustments are allowed if deemed medically necessary by the investigator and following discussion with the medical monitor * chronic and stable doses of losartan, fenofibrate, guaifenesin, and sodium-glucose linked transporter-2 inhibitors are permitted if the dose is stable for at least 14 days prior to study medication dosing. * subject is unable or unwilling to comply with the study requirements or has a situation or condition that, in the opinion of the investigator, may interfere with participation in the study.
artificial intelligence-supported reading versus standard double reading for the interpretation of magnetic resonance imaging in the detection of local recurrence for nasopharyngeal carcinoma: a randomised controlled multicenter study

Conditions: Artificial Intelligence Supported Image Reviewing

Summary: the aim of this randomized controlled study is to investigate whether the previously developed artificial intelligence model can triage post-radiotherapy magnetic resonance images of patients with nasopharyngeal carcinoma and assist radiologists in their interpretation.


Eligibility criteria:
inclusion criteria: * patients with treatment naive nasopharyngeal carcinoma who had finished radiotherapy for 6 months or more * the previous magnetic resonance imaging examination had showed complete remission in the primary site * images are acquired using a 3t magnetic resonance imaging device, including unenhanced t1-weighted and t2-weighted sequences and contrast-enhanced t1-weighted sequences exclusion criteria: * patients are enrolled in this study for a specific magnetic resonance imaging scan and not for subsequent follow-up magnetic resonance imaging scans.

Keywords: artificial intelligence image reviewing magnetic resonance imaging
non-ira functional evaluation with accuffrangio in nste-acs

Conditions: Non ST Segment Elevation Acute Coronary Syndrome; Coronary Artery Disease; Percutaneous Coronary Intervention

Summary: this is a prospective, single-center clinical trial. accuffrangio (arteryflow technology co., ltd., hangzhou, china) is a novel method for evaluating the functional significance of coronary stenosis by computing the pressure in the vessel based on angiographic images. the purpose of this study is to investigate the diagnostic performance and prognostic ability of accuffrangio for non-ira in nste-acs patients.


Eligibility criteria:
inclusion criteria: * 18 years and older * non-st-segment elevation acute coronary syndrome patients with at least 1 non-ira * diameter stenosis of 50%-90% by visual estimate * reference vessel size \> 2 mm in stenotic segment by visual estimate exclusion criteria: * lvef ≤ 40% * egfr \< 60 ml/min * allergy to contrast media, adenosine * prior cabg
comparison between metformin and glyburide in the management of gestational diabetes

Conditions: Gestational Diabetes Mellitus in Pregnancy

Summary: this study aims to compare the maternal, fetal, and neonatal outcomes associated with the use of metformin versus glyburide for managing gestational diabetes. the objective is to assess the safety and effectiveness profiles of both medications as potential alternatives to initiating insulin therapy.

primary outcome: treatment failure is defined as the initiation of insulin due to failure of glycemic control (more than 10% of high values using 4-point glucose checks) or side effects. secondary outcomes: maternal: * percentage of fasting and postprandial glucose levels within target levels after initiation of treatment * incidence of maternal hypoglycemia * reported maternal side effects * maternal weight gain * preterm delivery * development of pregnancy-induced hypertension * labor dystocia. * instrumental delivery and its indication (fetal compromise, delay in progress, or maternal exhaustion) * mode of delivery * incidence of third and fourth perineal tear fetal and neonatal: * fetal large for gestational age * intrauterine fetal death * newborn weight * gestational age at delivery * neonatal birth injuries * stillbirth and neonatal death * apgar score at 1 minute

Eligibility criteria:
inclusion criteria: * pregnant women over 18 years old. * gestational age between 24 - 28 weeks. * new diagnosis of gestational diabetes mellitus using a 2-hour glucose tolerance test. * medical therapy is indicated to control blood glucose following the failure of diet and lifestyle changes to solely achieve glycemic control (a2gdm). exclusion criteria: patients with pre-gestational diabetes. * first trimester fasting blood glucose ≥105 mg/dl or hba1c \> 6.4%. * major fetal anomalies. * intrauterine growth restriction (iugr) before 24 weeks. * abnormal renal or liver function. * contraindications to metformin or glyburide. * medical treatment declined by the patient. * direct indication to commence insulin (initial fasting blood glucose \>= 7 mmol/l or 126 mg/dl or \>= 6 mmol/l or 108 mg/dl with macrosomia or polyhydramnios). * significant medical co-morbidities requiring continuous medical treatment in pregnancy. * non-compliance to blood glucose self-monitoring (missing 50% or more of total readings)

Keywords: metformin and glyburide
miniplate versus k wires in management of metacarpal fracture

Conditions: Metacarpal Fracture

Summary: to compare between buried k wires and miniplate in management of metacarpal fracture.

fractures of the carpals, metacarpals and phalanges account for approximately 15-19% of fractures in adults, with 59% of these occurring in the phalanges, 33% in the metacarpals and 8% in the carpal bones \[1\]. the single most common fracture site in the hand is the sub capital region of the fifth metacarpal bone (boxer's fracture) \[2\], which usually results from a direct blow to the metacarpal head \[3\]. most hand fractures are caused by accidental falls or other sports-related injuries \[4\]. hand fractures are among the most common fractures of upper extremity \[5, 6\]. hand fractures can be treated conservatively or surgically, depending on the severity, location and type of fracture. the main objective of both operative and non-operative treatments is to provide fracture stability for early mobilization \[7\]. surgical fixation is mainly indicated for displaced fractures because casts are often not sufficient to maintain reduction \[8\]. open reduction with internal fixation (orif), using pins or plates, has historically been used to stabilize hand fractures which have rotational deformity or lateral angulation \[9\]. open reduction may result in scarring, joint stiffness and tendon adhesion \[7\]. closed reduction with internal fixation (crif), using percutaneous k wire or screws, is now used to treat the majority of unstable closed simple hand fractures \[10\]. it is generally considered percutaneous kirschner wire (k wire) fixation may not provide adequate stabilization to allow for early mobilization \[8\] .

Eligibility criteria:
inclusion criteria: 1. age: ( 20-60) years, 2. fresh (fixed within 3 days), 3. single or multiple fractures of metacarpals. exclusion criteria: 1. pathological fracture, 2. major systemic illness, malignancy, 3. patient on drugs affecting fracture healing like steroid, anticancer drugs, 4. polytrauma patients, 5. extensive comminution of the metacarpal or phalanx detected pre- or intra-operatively, 6. dislocations at either end of the fractured bone 7. parents/guardians/patients not willing to participate in study.