Kornimate/medical-research-clean huggingface dataset:
show improved vision with the hoya af-1 aspheric intraocular lens after cataract surgery

Conditions: Cataracts

Summary: the doctors participating in this study are looking to show improved vision with the hoya af-1 aspheric intraocular lens after cataract surgery. they will also study the use of revital vision (neuro-sensory testing) in providing the highest potential for improved vision.


Eligibility criteria:
inclusion criteria: 1. patients must desire to pursue some type of mono-vision fit, mono-vision lasik, or mono-vision cataract surgery with lens implant. 2. patients must be candidates for intraocular lens implantation for the correction of aphakia following extracapsular cataract extraction by phaco-emulsification. 3. patients must be candidates for bilateral implantation and desiring post-operative spectacle independence through targeted mono-vision. 4. patients must have less than 1.50 diopters of corneal astigmatism 5. patients must have the potential for best corrected visual acuity of 20/30 or better in each eye. 6. patients must have the mental capacity to cooperate when undergoing a detailed postoperative refractive examination. 7. patients must be an adult. 8. patients must provide written informed consent for cataract surgery. 9. patients must be willing and able to return for scheduled follow-up examinations for a period of 3 months (post-second eye) post-operatively. 10. patients must be willing and able to provide feedback to various survey questions regarding overall satisfaction and ease of adaptation to mono-vision and range of vision, etc. exclusion criteria: 1. patients with 1.50 diopters or more of corneal astigmatism 2. patients requiring a lens power less than 6 d or greater than 30 d 3. patients with any anterior segment pathology (chronic uveitis, iritis, iridocyclitis, rubeosis iridis, corneal dystrophy or corneal degeneration, tear film deficiency, poor pupil dilation, etc.). 4. patients with uncontrolled glaucoma or who require current treatment for glaucoma, or with visual field loss as a result of glaucoma. 5. patients with retinal pathology or a history of retinal detachment. 6. patients with proliferative diabetic retinopathy, macular degeneration, or other degenerative visual disorders. 7. patients with a history of previous ocular surgery including corneal refractive surgery. 8. patients with congenital bilateral cataracts. 9. patients with marked microphthalmos or aniridia. 10. patients who have only one functioning eye. 11. patients who do not have the potential for visual acuity of 20/30 or better in each eye. 12. patients lacking intact binocular vision. 13. patients who do not have an intact capsulorhexis and posterior capsular bag at the time of cataract removal and lens implantation. 14. patients who have incomplete or damaged zonules, or who have zonular rupture during cataract removal. 15. patients with pupils greater than 7mm

Keywords: cataract surgery
a study to evaluate the pharmacokinetics of crizotinib (pf-02341066) in subjects with impaired renal function

Conditions: Renal Impairment

Summary: the present study is being conducted to evaluate whether or not severe renal impairment has an effect on crizotinib pharmacokinetics.


Eligibility criteria:
inclusion criteria: all subjects * healthy male and/or female of non childbearing potential subjects between the ages of 18 and 65 years, inclusive ('healthy' is defined as no clinically relevant abnormalities identified by a detailed medical history, full physical examination, including blood pressure and pulse rate measurement, 12 lead ecg, and clinical laboratory tests). * body mass index (bmi) of 18 to 40 kg/m2 inclusive; and a total body weight \>50 kg (\>110 lbs). subjects with normal renal function (group 1) * normal renal function (clcr =\>90 ml/min) during the screening period. * matched 1-to-1 to subjects in group 2 with respect to age (+/-5 years), weight (+/-10 kg), gender, and race according to protocol. subjects with severe renal impairment (groups 2) * good general health commensurate with the population with chronic kidney disease. * severe renal impairment (clcr\<30 ml/min) during the screening period. exclusion criteria: all subjects * renal allograft recipients. * any condition possibly affecting drug absorption. * 12 lead ecg demonstrating qtc \>470 msec at screening. * urinary incontinence without catheterization. * a positive urine drug screen. * history of regular alcohol consumption. * treatment with an investigational drug within 30 days (or as determined by the local requirement, whichever is longer) or 5 half lives preceding the first dose of study medication. * pregnant or nursing females; females of childbearing potential, including those with tubal ligation. * blood donation of approximately 1 pint (500 ml) within 56 days prior to dosing. subjects with severe renal impairment (groups 2) * subjects with any significant hepatic, cardiac or pulmonary disease (apart from stable ischemic heart disease), or subjects who are clinically nephrotic. * subjects requiring hemodialysis. * subjects with strict fluid restriction (ie, \<1500 ml/24 hours). * significant bleeding diathesis which could preclude multiple venipuncture. * use of food or drugs that are cyp3a4 inhibitors and inducers. * herbal supplements and hormone replacement therapy must be discontinued 28 days prior to the first dose of trial medication * concurrent use of drugs that are cyp3a4 substrates with narrow therapeutic indices.

Keywords: renal impairment crizotinib pharmacokinetics
efficacy of various aerobic exercises on abdominal obesity in women with metabolic syndrome.

Conditions: Metabolic Syndrome

Summary: objective: to show metabolic and hormonal responses and effects on abdominal obesity of aerobic exercise in different intensity and duration and detraining period in women with metabolic syndrome.

objective: to show metabolic and hormonal responses and effects on abdominal obesity of aerobic exercise in different intensity and duration and detraining period in women with metabolic syndrome. methods: fifty-one women with metabolic syndrome were divided into three groups: 12 weekly sessions of high intensity supervised treadmill group, respectively, at % 70 of maximum oxygen consumption (group i, n=17), low intensity supervised treadmill group, respectively at % 50 of maximum oxygen consumption (group ii, n=17) and walking at low intensity, respectively at % 50 of maximum oxygen consumption with ecepedo pedometer (group iii, n=17). target heart rate (hr) corresponding to values of 50-70 % vo2max were determined by the submaximal treadmill test. group 1 and 2 were instructed walking at their target hr on a treadmill. the number of steps taken in a minute corresponding to target hr was determined by a criterion pedometer and group 3 was instructed walking in this step range recorded to ece pedo giving audible feedback. participants were evaluated by weight, bmi, waist circumference (wc), blood sugar, ldl, hdl and triglyceride; viseral fat, trunk fat and waist circumference by bioelectrical impedance device (viscan); ergospirometric vo2max at baseline, 12-week and 4-week detraining period.

Eligibility criteria:
inclusion criteria: * eligible participants who meet the criteria for inclusion were women with metabolic syndrome diagnosis according to national cholesterol education program adult treatment panel iii (ncep atp iii) criteria and were 25-65 years old. * participants were well communicative, motivated and willing to participate in the study. exclusion criteria: * the exclusion criteria were presence of uncontrolled hypertension, type 2 diabetes mellitus, atherosclerotic heart disease, using drugs to affect thyroid, lipids metabolism and insulin sensitization, musculoskeletal or systemic diseases contradicting the exercise, a neurological or psychiatric disease affecting cooperation and cognitive function.

Keywords: aerobic exercise metabolic syndrome pedometer
e-health coping skills training for women whose partner has a drinking problem

Conditions: Alcohol Abuse

Summary: this study evaluates web-based interventions to help women cope with the stress arising from living with a problem-drinking partner


Eligibility criteria:
inclusion criteria: * resides in new york state * fluent in english * male partner has an alcohol problem * computer access and smart phone * married or cohabiting exclusion criteria: * substance use disorder * serious mental disorder * participation in prior studies * severe relationship violence
phase i pilot study to evaluate the prognostic value of perfusion ct for primary cervical cancer

Conditions: Cervical Cancer

Summary: the investigators hope to learn whether perfusion ct is a useful way to assess primary cervical tumor microenvironment and whether there is a relationship between pretreatment perfusion ct measurements and primary cervical tumor size, lymph node involvement (as assessed by standard of care pretreatment fludeoxyglucose positron emission tomography/ct (fdg-pet/ct)), and treatment response (as assessed by standard of care 3-month post-therapy fdg-pet/ct).


Eligibility criteria:
inclusion criteria: * \>18 years old * with biopsy-proven squamous, adenocarcinoma or adenosquamous cervical cancer * no history of prior pelvic radiation and should be able to receive chemoradiation * non-pregnant women who have not previously undergone a hysterectomy, as that would have removed the cervix. * able to give informed consent exclusion criteria: * subjects whose tumors are not fdg avid on the pre-therapy pet. * allergy or inability to receive iodinated ct contrast

Keywords: cervix uteri
a study to estimate the effect of pf-06651600 on the pharmacokinetics (pk) of oral contraceptive (oc)

Conditions: Healthy Females

Summary: this is a phase 1, randomized, 2 way crossover, multiple dose, open label study of the effect of multiple dose pf-06651600 on single dose oc pk in healthy female subjects. subjects will be randomized to 1 of 2 treatment sequences.


Eligibility criteria:
inclusion criteria subjects must meet all of the following inclusion criteria to be eligible for enrollment in the study: 1. healthy female subjects of non childbearing potential female subjects of non childbearing potential must meet at least 1 of the following criteria: 1. achieved postmenopausal status, defined as follows: cessation of regular menses for at least 12 consecutive months with no alternative pathological or physiological cause; and have a serum follicle stimulating hormone (fsh) level confirming the postmenopausal state; 2. have undergone a documented hysterectomy and/or bilateral oophorectomy; 3. have medically confirmed ovarian failure. all other female subjects (including female subjects with tubal ligations) are considered to be of childbearing potential and are not eligible for this study. 2. body mass index (bmi) of 17.5 to 35 kg/m2; and a total body weight \>50 kg (110 lb). exclusion criteria subjects with any of the following characteristics/conditions will not be included in the study: 1. evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurological, or allergic disease (including drug allergies, but excluding untreated, asymptomatic, seasonal allergies at the time of dosing). 2. history of drug abuse with less than 6 months of abstinence prior to the baseline visit. 3. history of regular alcohol consumption exceeding 7 drinks/week for female subjects (1 drink = 5 ounces \[150 ml\] of wine or 12 ounces \[360 ml\] of beer or 1.5 ounces \[45 ml\] of hard liquor) within 6 months before screening. 4. any medical reason which would contraindicate the administration of oral contraceptives (as per the label) or history of discontinued use of oral contraceptives due to medical reasons. 5. subjects with a known immunodeficiency disorder or a first degree relative with a hereditary immunodeficiency. 6. subjects who have a malignancy or a history of malignancy, with the exception of adequately treated or excised non metastatic basal cell or squamous cell cancer of the skin or cervical carcinoma in situ. 7. any current evidence of untreated active or latent or inadequately treated infection with mycobacterium tuberculosis (tb). 8. history of human immunodeficiency virus (hiv), hepatitis b, or hepatitis c; positive testing

Keywords: female post-menopausal healthy oral contraceptive
pressure variability study

Conditions: Heart Failure

Summary: the purpose of this study is to understand how the pressure in the pulmonary artery changes under different conditions of posture, respiration and exertion.

this is a prospective, multi-center, observational study with enrollment up to 30 subjects at 2 u.s. sites. all study data can be collected on a single day as a one-time visit (lasting approximately 90-120 minutes). this study is a non-significant risk (nsr) investigational device exemption (ide) study as linq™ hf investigational ramware is required to activate additional sensors in the reveal linq icm. the patient will come to the clinic for a single in-office visit. pa pressure will be measured while the patient is in a variety of positions and during different respiratory exercises and after brief exertion. data will be collected on ecrfs. the effects of the different postures, respiration and exertion will be quantified using descriptive statistics (mean, standard deviation).

Eligibility criteria:
inclusion criteria: * investigator believes the patient's condition is sufficiently stable to safely participate in the study procedures * subject is currently implanted with a commercially available pulmonary artery pressure sensor and device communication has been reliable (recent history of successful communications with patient communication system) exclusion criteria: * subject has a history of primary pah
effects of chronic antihypertensive therapy on clinical outcomes in septic shock

Conditions: Atrial Fibrillation; Septic Shock

Summary: retrospective two-cohort study to determine the effect of chronic antihypertensive therapy on new onset atrial fibrillation and clinical outcomes in septic shock.

this will be a retrospective two-cohort study to determine the effect of chronic antihypertensive therapy on new onset atrial fibrillation and clinical outcomes in septic shock. the two cohorts will be septic shock patients that were: 1) not on either a chronic β-blocker or angiotensin-converting-enzyme inhibitor (ace inhibitor) or 2) on a chronic β-blocker, on chronic ace-inhibitor, or on both chronic β-blocker and ace-inhibitor

Eligibility criteria:
inclusion criteria: * adult patients 18 years of age or older * diagnosis of septic shock requiring vasopressor therapy (norepinephrine, epinephrine, phenylephrine, dopamine, or vasopressin) * admitted to the medical intensive care unit (micu) at rush university medical center (rumc) * time frame: 01/01/2012 to 07/1/2016 exclusion criteria: * pregnant patients * transfer from outside hospital on vasopressors * admitted to micu in cardiopulmonary arrest * prior arrest within 24 hours of admission to rumc

Keywords: chronic antihypertensives new onset atrial fibrillation septic shock
brief child safety interventions in emergency departments (safety in seconds)

Conditions: Injury Prevention

Summary: safety in seconds is a randomized controlled trial of a computer tailored injury prevention program which was conducted in the waiting area of a level 1 pediatric trauma center. a computer kiosk was used to randomly assign participants to study groups, collect baseline data and generate tailored reports based on responses to assessment items. an intervention group received a personalized and stage-tailored safety report and a control group received a personalized, but otherwise generic report on other child health topics. telephone follow-up interviews were conducted 2-4 weeks and again 4-6 months after enrollment. home visits were completed for a subset (n=100) of parents who completed the 4-6 month follow-up interview. the study aimed to increase knowledge, self reported and observed safety behaviors.


Eligibility criteria:
inclusion criteria: * eligible parents or guardians had to be english-speaking; * have a child between 4-66 months of age seeking treatment for an injury or medical complaint, or have an age-appropriate sibling of a child being seen for these reasons; * live in baltimore city; * and live with the child at least some of the time. exclusion criteria: -parents which did not meet inclusion criteria

Keywords: injury prevention smoke alarms car seats
nutrition sufficiency, allergy efficacy and safety of neocate jr in children with food protein allergy

Conditions: Food Allergy in Children; Cow Milk Allergy

Summary: the main purpose of this study is to evaluate efficacy and safety of an amino acid-based formula neocate jr in children with food protein allergy, and to evaluate nutrition sufficiency of neocate jr in 1 to 10 years old children with food protein allergy.

this is an open, self-controlled multi-center clinical study. target population is 1～10 years old children allergic to cow's milk and/or food protein, confirmed by pediatrician. the study plans to recruit about 50 subjects to have an intervention period of 4 weeks. data will be collected at baseline, week 1, 2 and 4. the hypothesis is that the amino acid formula (neocate jr) is effective in relieving food protein allergy symptoms, and meanwhile supporting normal growth in children with food protein allergy. efficacy parameters are the the improvement of food protein allergy symptoms (scorad score, serum ige), growth and development index (weight, height, weight for height), and nutrition related labs (such as hemoglobin, total blood protein, albumin, pre-albumin).

Eligibility criteria:
inclusion criteria: * 1～10 years old * the children with cow's milk/food protein allergy confirmed by pediatrician including sequential feeding/newly diagnosed children, and children with eosinophilic esophagitis, gastroesophageal reflux disease, food protein-induced enterocolitis syndrome (clinical symptoms and signs, ige, oral food challenge, etc.) * stable vital signs * written informed consent from the children's parents/guardian exclusion criteria: * allergic to any ingredient in the recipe * gi function failure * complete obstruction of the digestive tract * intractable diarrhea * noncooperation of neurologic or mental diseases * disapproval of pediatricians
impact of age and bmi on liver transplant outcomes

Conditions: Liver Transplant; Complications; Perioperative/Postoperative Complications

Summary: prospectively enrolled retrospective chart review and liver transplant database review to determine the modifiable and nonmodifiable risk factors specifically relating to living donor liver transplants. to observe the impact of age and bmi on graft outcomes and whether they impact the intraoperative management, post-operative length of stay, and complications.

there has been a great deal of research into the characteristics of the donor for organ transplant, with older donors and those with more comorbidities having worse function once the organ is implanted. there has not been a great deal of research in the united states about the recipient's characteristic including age and bmi and the effects on donor organ function. with increasingly expanded criteria for organ recipients especially in the field of living donor organs the investigators plan to show the impact of older age and increased bmi on newly transplanted organs.

Eligibility criteria:
inclusion criteria: * all patients who received a liver transplant at upmc- montefiore hospital age\> 18 exclusion criteria: * excludes children (\<18 years old) as they do not receive their operation under the same protocols lost to follow-up prior to 1 year participation in alternate research protocol that significantly altered the care they received in the perioperative period that may make their inclusion skew results.

Keywords: age related outcomes bmi related outcomes liver transplantation
the need for rehabilitation and the connection with attachment styles among patients with gynaecological cancer

Conditions: Needs for Rehabilitation; Adult Attachment Style; Quality of Life.; Depression; PTSD

Summary: the purpose of this study is to provide new knowledge about: * integration of rehabilitation in a highly specialized gynaecological department. * development and testing of an individually adapted rehabilitation process. * needs for rehabilitation among women with gynaecological cancer. * connection between adult attachment style for women with gynaecological cancer and their quality of life, rehabilitation needs and symptoms of depression /ptsd.


Eligibility criteria:
inclusion criteria: * suspicion of gynaecological cancer * surgery for gynaecological cancer exclusion criteria: * do not speak danish
inspiratory muscle strength training for sleep-related breathing disorders

Conditions: Obstructive Sleep Apnea

Summary: the purpose of the current study is to investigate the effects of a novel breathing training, called inspiratory muscle strength training (imst), on sleep patterns, breathing and blood pressure for patients diagnosed with mild, moderate and severe sleep apnea.

aims of the study: 1. to determine the influence of imst on resting blood pressure and baroreceptor sensitivity. 2. to determine the effect of imst on sympathetic nervous system by measuring plasma cathecholamines and nerve recording (msna). population: 30 subjects aged 30-75 years, who have previously been diagnosed with obstructive sleep apnea, as defined by the national institutes of health (national heart lung, and blood institute) will be included in this study. study protocol: * pre-training assessment and overnight sleep study * 5-10 minutes each day breathing training (imst) at home using a hand-held device for 6 weeks * once weekly laboratory visit * post-training assessment and overnight sleep study pre- and post-training assessment include blood pressure measurement, body weight, neck circumference, cardiorespiratory monitoring, nerve recording, blood draw and sleep surveys.

Eligibility criteria:
inclusion criteria: * age 30-75 years * diagnosed with obstructive sleep apnea with apnea hypopnea index (ahi) \> 15 * neck circumference \> 16 cm exclusion criteria: * body mass index (bmi) \> 40kg/m2 * implanted pacemaker * on anticoagulant medication * on hypnotic medication * on immunosuppressive medication * acute or recent (3 months prior to study) infection * history of hypothyroidism * history of stroke or neuromuscular disease * moderate to severe heart failure * severe ischemic heart disease * severe obstructive and restrictive lung disease * cor pulmonale * cognitive disorders * obstructive nasal disease or history of spontaneous pneumothorax or rib fracture * history of neurological, respiratory, head /neck, or thoracic surgery

Keywords: obstructive sleep apnea inspiratory muscle strength training baroreceptor sensitivity blood pressure