Kornimate/medical-research-clean huggingface dataset:
association study of gene polymorphisms with cardiac performance

Conditions: Genetic Polymorphism; Coronary Artery Disease; Hemodynamics

Summary: the purpose of this study is to determine whether polymorphisms in g protein subunits, namely galphas and galphaq, are associated with altered cardiac performance in heart failure patients.

g protein pathways plays a pivotal role in mediating positive inotropy and cardiac hypertrophy by transducing signals of neurohormones in cardiomyocytes. single nucleotide polymorphisms (snps) in the g protein subunits galphas and galphaq have been shown to result in altered protein expression. we now want to examine whether g protein polymorphisms alter nyha functional class, and hemodynamic variables in patients with coronary artery disease scheduled for coronary artery bypass grafting .

Eligibility criteria:
inclusion criteria: * clinical diagnosis of coronary artery disease * patients scheduled for coronary artery bypass grafting exclusion criteria: * emergency operation * combined vitium
beijing friendship hospital metabolic surgery database

Conditions: Metabolic Surgery

Summary: metabolic surgery, as a recognition treatment option for patients with clinical morbid obesity, is gaining increasing appreciation. in addition to substantial weight loss, emerging studies have highlighted that metabolic surgery can substantially ameliorate obesity-related metabolic diseases, including but not limited to type 2 diabetes mellitus (t2dm), hypertension, dyslipidemia, obstructive sleep apnea-hypopnea syndrome (osahs) and polycystic ovary syndrome (pcos)in severely obese patients. however, further investigations with larger sample size and longer observation time still needed to clarity the efficacy and safety of metabolic surgery in chinese patients with obesity and encouraging future research in this field.


Eligibility criteria:
inclusion criteria: * be able to receive metabolic surgery (lsg or lrygb) exclusion criteria: * can not be able to understand and willing to participate in this registry with signature

Keywords: metabolic surgery metabolic disease
radiographic and inflammatory biomarker changes in chronic low back pain

Conditions: Low Back Pain

Summary: objective: to find and compare the effects of isokinetic training and virtual reality training on pain intensity, trunk muscle strength, radiographical (muscle cross-sectional area and muscle thickness), and biochemical effects in chronic low back pain (lbp) patients.

objective: to find and compare the effects of isokinetic training and virtual reality training on pain intensity, trunk muscle strength, radiographical (muscle cross-sectional area and muscle thickness), and biochemical effects in chronic low back pain (lbp) patients. methods: randomized, double-blinded controlled study was conducted on 60 lbp patients and they were divided into isokinetic training (ikt; n=20), virtual reality training (vrt; n=20), and a control group (n=20). the vrt group received virtual training for core muscles of the trunk, the ikt group received training for trunk muscles through an isokinetic dynamometer and the control group received conventional trunk balance exercises. pain intensity (visual analog scale -vas), trunk muscle strength, radiographical (muscle cross-sectional area through magnetic resonance imaging - mri \& muscle thickness through ultrasound - us), and biochemical (crp, tnf-α, il-2, il-4, il-6) variables were measured at baseline and after 4 weeks (short term effect) of training.

Eligibility criteria:
inclusion criteria: * university male football players * age group of 18 - 25 years * chronic (≥3 months) lbp, * 4 to 8 pain intensity in visual analog scale (vas). exclusion criteria: * participants with severe musculoskeletal, neural, somatic, and psychiatric conditions, * waiting for spine surgery, * having alcohol or drug abuse, * involved in other weight and balance training programs. * participants with other soft tissue injuries, fractures in the lower limbs and pelvic bone, deformities.

Keywords: isokinetic training virtual reality training cross sectional area muscle thickness inflammatory biomarkers chronic low back pain
pain relief effects on length of labor

Conditions: Labor Pain

Summary: this study divides patients into two groups when they ask for medicine to help relieve the pain of contractions. one group will be selected to receive an epidural and another group will be selected to receive both a spinal dose and an epidural. the investigators will then measure how long it takes to deliver the baby. the investigators think that the group that has the combination spinal and epidural will have a faster labor.

in this randomized controlled trial, the investigators will evaluate conventional continuous lumbar epidural analgesia compared to the combined spinal-epidural analgesia. the primary outcome of interest will be duration of the active phase of the first stage of labor. secondary outcomes include the cesarean delivery rate, operative vaginal delivery rate, analgesia requirements, maternal and neonatal safety profiles (incidence of maternal hypotension, post puncture dural headache, fetal acidemia and nicu admissions, respectively), adequacy of maternal pain relief will also be measured using visual analog scores (vas). the investigators hypothesize that the instantaneous pain relief that is achieved with combined spinal-epidural analgesia reduces catecholamines quickly and to a greater degree than the conventional epidural, leading to a more effective uterine contraction pattern thus decreasing the duration of the active phase of the first stage of labor.

Eligibility criteria:
inclusion criteria: * nulliparous women * term gestation, defined as equal to or greater than 37 weeks * ages 16-44 years * singleton gestation * cephalic presentation * induction of labor on monday 0700 through friday 0700 at parkland hospital * intact membranes on admission exclusion criteria: * chorioamnionitis at randomization * intrauterine fetal death * coagulopathy * allergies to amide local anesthetics * localized back infection

Keywords: labor analgesia epidural spinal
the effects of treadmill training with visual and auditory cues on gait parameters in parkinsonian patients in advanced stages of disease.

Conditions: Parkinson Disease

Summary: the first aim of this study was to evaluate the effect of a gait training using treadmill with visual and auditory cues in patients in stages iv hoehn \& yahr (h\&y). the second aim was to compare the obtained data of these patients in advanced stages with those in mild to moderate stages.

gait is altered in parkinson's disease (pd) patients. it has been shown that treadmill training with visual and auditory cues is useful in improving the gait's parameters in patients in early-moderate stages of disease. no data are available about the effectiveness of this training in those subjects in advanced stages of pd. the first aim of this study was to evaluate the effect of a gait training using treadmill with visual and auditory cues in patients in stages iv hoehn \& yahr (h\&y). the second aim was to compare the obtained data of these patients in advanced stages with those in mild to moderate stages. 150 patients with pd in early-moderate and advanced stages of disease (50 in h\&y stage 2, group 1, 50 in h\&y stage 3, group 2 and 50 in h\&y stage 4, group 3) were enrolled. all patients underwent an intensive treatment: 20-minutes treadmill training per day, 6 times a week, for 4 weeks. treadmill speed was previously set at 2.0 km/h and progressively increased until a maximum of 3.5 km/h, taking always into account the patients' physical abilities. all patients were evaluated at the enrolment and at the end of the 4-weeks treatment. the first evaluation consisted in one-minute walking on treadmill without the use of cues at 1.5 km/h speed, for all patients. the outcome measurements were: the average length of the right step, the average length of the left step, the coefficient of variance of both steps, and the gait cycle.

Eligibility criteria:
inclusion criteria: parkinson disease exclusion criteria: comorbidity with other neurological condition

Keywords: parkinson disease treadmill rehabilitation
the treatment of carpal tunnel syndrome using thumb pressure along the median nerve

Conditions: Carpal Tunnel Syndrome

Summary: the purpose of this study is to find the efficacy of treating the muscles in the inside (biceps,pronator teres) of the arm in order to eliminate the carpal tunnel syndrome .the authors hypothesise that eliminating the trigger points located in these muscles would diminish the symptoms associated with the carpal tunnel syndrome.

the carpal tunnel syndrome is a common condition which should treated by surgery only when conservative approaches has been tried.in the present trial the authors intend to find the effectiveness of treating the triggers points located in the biceps muscle, the pronator teres muscle and the biceps aponeurosis on the symptoms normally associated with the carpal tunnel syndrome. the technique used in this trial will be ischemic compression(thumb tip pressure)on the trigger points located on the previous sites.

Eligibility criteria:
inclusion criteria: * adults between 20 and 60 years old from the city and the surrounding trois-rivières with chronic carpal tunnel syndrome, * daily pain in the hand that lasted at least 3 months exclusion criteria: * history of upper limb or neck surgery, * pregnancy and systemic pathologies possibly related to carpal tunnel syndrome, such as hypothyroidism, diabetes and rheumatoid arthritis.
retrograde ejaculation and sexual dysfunction in men with diabetes mellitus

Conditions: Diabetes Mellitus

Summary: diabetic men and controls are examined for retrograde ejaculation, and erectile dysfunction is registered with a validated questionaire (international index of erectile function-15). concentration, total number of sperm and motility is determined in freshly delivered ejaculates and postejaculatory urine. our hypothetis is that diabetics exhibit significantly higher rate of retrograde ejaculation than healthy controls.


Eligibility criteria:
inclusion criteria: * men 30-55 years of age * men registered in a diabetic biobank including 6000 diabetics and 6000 controls exclusion criteria: * men who do not understand danish
a positive psychology intervention for patients with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: positive psychology (pp) uses targeted activities to increase the frequency and intensity of positive emotional experiences such as positive affect. examples of pp activities include recalling positive life events and performing acts of kindness. this pilot study will examine the tolerability and efficacy of a pp training program to increase positive affect in patients with multiple sclerosis (ms). in the intervention phase, subjects randomized to the intervention group will complete five weeks of pp exercises, one exercise per week. subjects will also have weekly calls with the study trainer. the control group will have no study activities. in the extension phase, subjects in the control group will complete pp training as described above. the investigators will examine the tolerability of the program by calculating the proportion of subjects who complete the program. the investigators will also examine exercise-specific ratings of ease and utility to measure the acceptability of each exercise. finally, the investigators will evaluate the efficacy of pp training by comparing subjects in the intervention and control groups on measures of positive affect, emotional function, health-related quality of life (hrqol) and self-reported functional activities such as work. if successful, this study will advance the use of pp as a low cost, innovative and effective tool for increasing positive affect, decreasing depression and anxiety and improving hrqol in patients with ms.


Eligibility criteria:
inclusion criteria: * diagnosis of multiple sclerosis according to the mcdonald 2010 diagnostic criteria * age 18-65 * ability to speak, read and write in english * enrollment in the comprehensive longitudinal investigation of multiple sclerosis at the brigham and women's hospital, partners ms center: the climb study. exclusion criteria: • moderate or marked cognitive abnormalities on brief mental status testing identified that would preclude meaningful participation in the pp exercises.

Keywords: positive psychology positive affect
database of monochorionic pregnancies

Conditions: Monochorionic Diamniotic Placenta; Monochorial Monoamniotic Placenta; Twin; Complicating Pregnancy; Twin to Twin Transfusion Syndrome; Twin Reversal Arterial Perfusion Syndrome

Summary: the purpose of this study is to collect and analyze data regarding natural history, indications for fetal interventions, and maternal and fetal/neonatal outcomes associated with complicated monochorionic twin pregnancy.


Eligibility criteria:
inclusion criteria: * the study population will consist of mc pregnancies (maternal, fetal, and neonatal data) that have undergone evaluation and/or treatment for complications attributable to monochorionic twin pregnancy at the university of miami. * maternal age 18 years and older. exclusion criteria: * participation declined or consent not granted in prospective arm * loss to follow-up

Keywords: multiple pregnancies twins
vermont oxford network very low birth weight database

Conditions: Neonatology

Summary: vermont oxford network maintains a database for live born infants \<=1500 grams or \<=29 weeks gestational age who are born at participating hospitals or admitted to them within 28 days of birth, regardless of where in the hospital the infant receives care.

the database collects observational baseline data on both mothers and infants, and the therapies used and outcomes of the infants. the information collected is not specific to a disease or treatment. the data collected includes information on: * demographics of mother and infant * mother's health, labor and delivery * infant's health upon admission, procedures and interventions, and medical outcomes these data are used to: provide member centers with reporting for use in quality improvement; examine associations between baseline characteristics, treatments, and outcomes; and track trends in incidences of disease and effectiveness of therapies.

Eligibility criteria:
inclusion criteria: * any infant who is born alive and whose birth weight is \<=1500 grams or \<=29 weeks 6 days gestational age (inclusive) who is born at or admitted to a vermont oxford network member center within 28 days of life without having first gone home, regardless of the where the infant receives care exclusion criteria: * stillborn infants * infants discharged home prior to admission to a member center * infants admitted after 28 days

Keywords: birth weight gestational age very low birth weight infant neonatal
modulation of behavioral inhibition in attention deficit hyperactivity disorder

Conditions: ADHD

Summary: the main purpose of this study is to investigate how the brain responds to a procedure known as transcranial direct current stimulation (tdcs) and how tdcs affects performance on a behavioral task. research suggest that this procedure leads to improvement in brain and behavioral measures of inhibitory control (controlling impulses) in healthy control participants. the investigators want to explore whether the same improvement will be seen in kids with adhd.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of adhd * parent informed consent and child assent exclusion criteria: * intracranial pathology from a known genetic disorder (e.g., neurofibromatosis type 1 (nf1), tuberous sclerosis) or from acquired neurologic disease (e.g. stroke, tumor), cerebral palsy, history of severe head injury, or significant dysmorphology * history of fainting spells of unknown or undetermined etiology that might constitute seizures * history of seizures, diagnosis of epilepsy, or immediate (1st degree relative) family history epilepsy * chronic (particularly) uncontrolled medical conditions that may cause a medical emergency in case of a provoked seizure (cardiac malformation, cardiac dysrhythmia, asthma, etc.) * history of head injury resulting in prolonged loss of consciousness * substance abuse or dependence within the past six months * chronic treatment with prescription medications that decrease cortical seizure threshold that the patient is unable to withhold from taking during study visits * damaged skin on the scalp (i.e., skin with ingrown hairs, acne, razor nicks, wounds that have not healed, recent scar tissue, broken skin, etc.)

Keywords: attention deficit hyperactivity disorder (adhd)
robustness and usability of the dreem 3 system for at home sleep monitoring in an insomnia population.

Conditions: Insomnia, Secondary; Sleep Disturbance; Sleep; Sleep Initiation and Maintenance Disorders

Summary: there is an unmet medical need for monitoring sleep for multiple nights in a patient's home, without the inconvenience of traveling and staying overnight in a medical center, and without the need for a technician to set up a polysomnography (psg) device at the patient's home. several disorders, and particularly sleep disorders, are associated with insomnia symptoms, and longitudinal sleep assessment may support a better understanding and management of these patients, who currently seldom access sleep lab psg. on one hand, this study aims at demonstrating whether the final device's user interface supports safe and effective use when being used at home over multiple nights. on the other, the study aims at confirming that stable and consistent data are measured in the device's actual use, for the records to be clinically usable in daily practice.


Eligibility criteria:
inclusion criteria: * subjects must be ≥ 22 and ≤ 70 years old inclusive, including: * 8 subjects under 55 years old. * 7 subjects over 55 years old. * subjects who are under the care of a sleep clinician for experiencing insomnia symptoms. * subjects have wifi connection at their home. * subjects have a smartphone where they can install the alfin app. * subjects agree to not having abnormal drugs or alcohol consumption 24 hours before the start of the measurement, and during the 3 days of measurement. * able to read, understand and sign an informed consent form. exclusion criteria: * under 22 and above 70 years old inclusive. * bmi ≥ 40. * obstructive sleep apnea diagnosis with ongoing cpap therapy. * abnormal drugs or alcohol use during the measurement part of the study. * head circumference \< 53 cm or device fitting issues as determined during training. * not able to read, understand and sign an informed consent form.

Keywords: polysomnography sleep assessment dreem eeg dry eeg accuracy
study kbp-2020-cphg documenting new cases of primary lung cancer (plc) diagnosed in respiratory medicine departments and lung cancer units at general hospitals from january 1st to december 31st 2020

Conditions: Lung Cancer

Summary: twenty years after kbp-2000-cphg study and ten years after kbp-2010-cphg study, the cphg proposes to conduct a new epidemiological study on primary plc in order to evaluate and analyze the changes that have occurred over the last decade. primary endpoint: estimate 1-year- and 5-year-mortality rates in patients with plc. secondary endpoints: * describe plc patient population managed by pulmonologists at french general hospitals in 2020 * describe plc diagnostic and therapeutic management by pulmonologists at french general hospitals in 2020 and compare them to kbp-2000-cphg and kbp-2010-cphg studies * estimate prognostic factors * compare patient and tumor characteristics to those observed for kbp-2010-cphg and kbp-2000-cphg studies * compare observed survival rates to those reported for kbp-2000-cphg and kbp-2010-cphg studies


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * primary lung cancer histologically (or cytologically or presence of a mutation on liquid biopsy with compatible imaging) proven between january 1st and december 31st, 2020\* * follow-up by a lung specialist at a general hospital * oral informed consent \* date of collected sample exclusion criteria: * age \< 18 years * secondary lung cancer * recurrence of same histological type plc- left to the investigator discretion according to the clinic and the imagery * previous enrolment in the study * freedom deprived patient following a legal or administrative decision * patient unable to give his(her) consent
study to assess drug levels and safety of golcadomide (bms-986369) in healthy participants and participants with different degrees of hepatic impairment

Conditions: Hepatic Impairment; Healthy Volunteers

Summary: the purpose of this study is to assess the drug levels and safety of golcadomide (bms-986369) in adult participants with moderate and severe hepatic impairment (hi), and in matched healthy control participants with normal hepatic function.


Eligibility criteria:
inclusion criteria for all participants (group a, group b, group c): * body mass index (bmi) between 18 and 40 kg/m\^2 (inclusive), and body weight ≥ 50 kg. inclusion criteria for participants with moderate or severe hepatic impairment (group a and group b): * participants have moderate hi (group a), severe hi (group b) or cirrhosis due to chronic hepatic disease and/or prior alcohol use. * participants have moderate (group a) or severe (group b) hi as defined by national cancer institute-organ dysfunction working group (nci-odwg) criteria. inclusion criteria for a matched healthy participant (group c): * participants must have liver-related laboratory test results within the respective reference ranges or with clinically insignificant excursions as agreed by the investigator and the sponsor medical monitor. * participants must be free of any clinically significant disease that would interfere with the study evaluations. exclusion criteria for all participants (group a, group b, and group c): * any surgical or medical condition possibly affecting drug absorption, distribution, metabolism, and excretion (adme). * history of major surgery within 8 weeks before the study intervention administration. * any other clinically significant medical, psychiatric, and/or social reason, or other active issues, as determined by the investigator. * other protocol-defined inclusion/exclusion criteria apply.

Keywords: healthy volunteers pharmacokinetics liver diseases moderate and severe hepatic impairment bms-986369 cc-99282 hepatic impairment golcadomide
a study of participants with squamous cell oesophageal carcinoma receiving nivolumab as part of an early access to medicines scheme (eams) program in the united kingdom

Conditions: Esophageal Squamous Cell Carcinoma

Summary: this purpose of this observational study is to review medical chart and patient survey data collection within an early access to medicines scheme (eams) program. participant who are eligible, provide consent and enroll into the squamous cell oesophageal cancer eams to receive nivolumab will be included in this study.


Eligibility criteria:
inclusion criteria: * adult participant (≥18 years of age) enrolling into the squamous cell (including adenosquamous) oesophageal cancer early access to medicines scheme (eams) and plans to initiate treatment with nivolumab * willing and able to comply with the study requirements and provide informed consent exclusion criteria: • does not receive at least one dose of nivolumab as part of the eams other protocol-defined inclusion/exclusion criteria apply

Keywords: bms-936558 early access to medicines scheme eams nivolumab prospective study quality of life real world evidence squamous cell oesophageal carcinoma survival