Kornimate/medical-research-clean huggingface dataset:
effect of antenatal corticosteroids on neonatal hypoglycemia

Conditions: Antenatal Corticosteroids

Summary: comparing the incidence of neonatal hypoglycemia in infants born to mothers who received antenatal corticosteroids to those who did not.

antenatal corticosteroids (acs) are widely used to enhance fetal lung maturation in pregnancies at risk of preterm birth. however, their role in early-term pregnancies (37 to 38 weeks gestation) prior to planned cesarean section has been gaining attention. early-term neonates delivered by cesarean section are at an increased risk of respiratory complications, and studies have shown that acs can reduce these risks by accelerating fetal lung development. the use of acs in this population, however, has raised concerns about its potential effects on neonatal metabolic outcomes, particularly neonatal hypoglycemia. neonatal hypoglycemia, a common metabolic disorder in the early postnatal period, is often associated with antenatal corticosteroid exposure. acs may increase fetal insulin production by stimulating pancreatic beta cells, leading to an increased risk of hypoglycemia after birth. research indicates that while acs effectively reduces respiratory morbidity in early-term neonates, it may concurrently raise the risk of neonatal hypoglycemia. for instance, a meta-analysis found a significant association between acs and an increased incidence of hypoglycemia in term and near-term infants. given these findings, research is crucial to assess the balance of risks and benefits of acs in early-term cesarean deliveries. while acs appears to reduce respiratory complications, understanding its full impact on neonatal hypoglycemia will help guide its use in clinical practice

Eligibility criteria:
inclusion criteria: - 1. women with singleton pregnancies at 37-38 weeks of gestation (early-term) scheduled for planned cesarean sections. 2. participants who have received antenatal corticosteroids prior to cesarean section as part of their prenatal care. exclusion criteria: * 1. women delivering before 37 weeks or after 39 weeks of gestation would be excluded, as the study focuses on early-term deliveries. 2. women with any form of diabetes, including pre-existing type 1 or type 2 diabetes, and gestational diabetes. this ensures that the study focuses on non-diabetic populations, as diabetes can independently affect neonatal glucose regulation and complicate the assessment of hypoglycemia risk due to corticosteroids. 3. women with severe maternal health such as preeclampsia, chronic hypertension, or other systemic illnesses, might be excluded to avoid confounding variables. 4. women who did not complete the full course of antenatal corticosteroids may be excluded, as the effect of partial doses could differ from complete treatment. 5. women with multiple gestations (e.g., twins or triplets) may be excluded due to the added complexity of multiple-birth pregnancies and their unique risk. 6. neonates with known congenital anomalies, genetic disorders, or other pre-existing medical conditions that could affect glucose metabolism
evaluation of sleep quality, nutrition, anxiety and depression in mastalgia

Conditions: Mastodynia

Summary: the aim of this study is to investigate the sleep quality, anxiety and depression levels in women with mastalgia using internationally validated scales. additionally the investigators aim to question the amount and frequency of consumption of nutritional elements which are known to aggravate mastalgia. finally by combining and analyzing the information gathered, the investigators intend to set light to the etiopathologic and clinic aspects of mastalgia.

mastalgia is encountered in 70% of premenopausal women and is one of the most frequent reasons for attending general surgery clinics. in most of the cases no physical cause is demonstrated and the etiopathogenesis is still not yet determined. in 1949 patey, for the first time, proposed that mastalgia might be a psychologically based problem. in the following years, research was focused in this issue and some articles were published demonstrating the relationship of anxiety, depression and high stress levels with mastalgia. the efforts for finding out the etiopathologic mechanism and defining the risk factors revealed that smoking and consumption of tea, coffee and carbonated beverages in particular worsen mastalgia whereas essential fatty acids (especially gamma linoleic acid) provides a symptomatic relief. additionally it is known that sleep irregularities cause serious deterioration in daily life quality as well as can exaggerate some medical, neurologic and/or psychiatric conditions. more than half of the population experience sleep irregularities from time to time and chronic sleep disturbances effect 20% of adult population in western countries. therefore sleep irregularities might have contributing effects in the etiopathogenesis and/or symptomatology of therapy resistant conditions like mastalgia.

Eligibility criteria:
inclusion criteria: * having mastalgia as a presenting symptom (mastalgia group) * presence of mastalgia confirmed by a general surgeon (mastalgia group) * absence of mastalgia (control group) exclusion criteria: * previously diagnosed breast carcinoma (both groups) * previously exposed to thoracic radiotherapy (both groups) * previous breast or thoracic surgery for any reason (both groups) * presence of tietze syndrome (both groups) * use of nutritional supplements (both groups) * presence of any self-perceived pain (control group) * presence of psychogenic based conditions and psychosomatic illnesses (control group)

Keywords: mastodynia anxiety depression sleep quality
comparison between hysterectomy and conservative management in treatment of placenta accreta regarding maternal complication

Conditions: Placenta Accreta

Summary: aim of the work the aim of the study is to compare the maternal morbidity and mortality between obstetric hysterectomy and conservative surgery for pregnant ladies \> 28 weeks with placenta accreta during caesarean section at ain shams university maternity hospital in the last five years and prospective study in the next six months. hypothesis in women with placenta accrete undergoing hysterectomy may be similar to conservative surgery as regard maternal morbidity and mortality.

the study included all cases of placenta accreta that were diagnosed preoperative or intra-operative and treated by conservative surgery or by hysterectomy during caesarean section between january 2011 to december 2015 at ain shams university maternity hospital and from july 2016 to january 2017. the collected data will be categorized according to the way of management and will be analyzed regarding: mortality rates. intraoperative morbidities: blood loss and it's amount and need for transfusion. amount of blood and blood products transferred. injury to adjacent organs eg: bladder or bowel injury. early postoperative morbidities: blood and blood product transfusion length of maternal hospital admission post operative acquiring intensive care unit admission and identifying the cause and duration wound sepsis septic shock peritonitis dvt acute pulmonary embolism hysterectomy after conservative management and its indication wound dehiscence burst abdomen late postoperative morbidities: anemia recurrence of placenta accretes in next pregnancy. hysterectomy after conservative management and its indication uterine necrosis fistula eg. urinary fistula

Eligibility criteria:
inclusion criteria: * women admitted for elective caesarean section. pregnant women more than 28weeks of gestation. women with no associated medical diseases eg. dm, pet. pre-operatively hemodynamically stable women. women diagnosed with placenta accrete either preoperative or accidentally discovered intraoperative. exclusion criteria: * pregnant women less than 28weeks of gestation. women with associated medical co-morbidity eg bleeding tendency eg: dm, pet.
microbial diversity of small bowel stoma effluent and colonic faeces

Conditions: Intestinal Failure

Summary: several studies suggested that dysbacteriosis usually happened in patients with intestinal failure (if). however, differences of microbiota diversity in small intestine stoma effluents and colonic faeces were rarely studies. thus this study is aimed to investigate the microbiota compositions and differences of output of small intestine stoma and colon in pediatric if patients. fecal samples from if patients. each patient received fistula closure in our centre and fecal samples from both small intestinal stoma and colon were collected. fecal microbial compositions were determined by high-throughput sequencing.


Eligibility criteria:
inclusion criteria: * patients with intestinal failure. patients showed good tolerance to parenteral and enteral nutrition administration. proportion of enteral nutrition is more than 80%. stool output maintained at less than 50ml/kg/day. no complications occurred for at least 1 week. exclusion criteria: * patients depend mainly on parenteral nutrition. symptoms like fever, abdominal distention and diarrhea. complications like parenteral nutrition-associated liver disease, pneumonia and catheter related infection.

Keywords: intestinal failure microbiota
helping eliminate marijuana use through pediatric practice

Conditions: Marijuana

Summary: this study adapts the public health service (phs) 5as model for use with adolescent marijuana users and pilot the intervention to test feasibility and acceptability in pediatric primary care settings. the specific aims are as follows: aim 1: develop a marijuana screening and brief counseling intervention for adolescents based on the public health service 5as model and previously developed adolescent smoking cessation intervention. hypothesis 1: the 5as model can be adapted for use as a marijuana screening and counseling intervention for adolescents. aim 2: test the feasibility and acceptability of the 5as marijuana screening and brief counseling intervention in pediatric primary care practice. hypothesis 2a: pediatric clinicians will find the 5as intervention feasible and acceptable for addressing marijuana use in routine clinical visits with adolescents and their families; and hypothesis 2b: adolescents will find the 5as intervention delivered by their clinicians to be acceptable in the context of routine preventive services delivery.

the hempp study involves three phases: researchers will (1) develop a marijuana screening and brief counseling intervention for adolescents, based on expert input, current literature, and themes gathered from focus groups with adolescents and clinicians; (2) pilot test the acceptability of the 5as marijuana intervention in 2 pediatric primary care practices, where researchers will test the intervention and determine acceptability via in-depth interviews with clinicians, office staff, adolescents and parents; and (3) pilot test the feasibility of the 5as marijuana intervention in 8 practices (4 intervention/4 comparable control), wherein each practice will enroll 100 adolescents and conduct baseline/exit interviews with all of them. twenty percent of adolescents/practice (including identified marijuana users) will complete one follow-up interview 3-6 weeks after their practice visit. these interviews will assess physician-delivery of the intervention and any change in use, attitude or behavioral intentions toward marijuana since their clinical visit. findings will inform the development of a future large-scale trial of adolescent marijuana use, screening and cessation counseling in pediatric primary care. the long-term goal is to improve clinical preventive services for adolescent marijuana cessation. conducting this work within the aap pros network will lead to rapid dissemination of effective interventions.

Eligibility criteria:
inclusion criteria: * adolescents presenting for regular well or sick visits at their pediatrician's office * must live in a home or apartment with access to a telephone and mailing address * must be cognitively able to consider the risks of marijuana use * must be able to speak english * must be able and willing to give informed consent (if 18 years of age or older) or assent (if 14-17 years of age) * in addition: parents/legal guardians of minors must be able and willing to give informed consent exclusion criteria: * none

Keywords: media use
a phase ia, dose escalation study of humanized anti-vegf monoclonal antibody (sevacizumab) injection in patients with advanced or metastatic solid tumors

Conditions: Advanced Solid Tumors; Metastatic Solid Tumors

Summary: this study is to assess the safety, tolerability and pharmacokinetics of single dose and multiple doses of humanized anti-vegf monoclonal antibody (sevacizumab) in patients with advanced or metastatic solid tumors. the secondary objective is to explore the preliminary anti-tumor effects.


Eligibility criteria:
inclusion criteria: * histologically or cytologically confirmed advanced or metastatic malignant solid tumors; * patients failed the standard anti-tumor therapy or don't have standard regimen; * at least one measurable lesion; * at least 4 weeks from the last chemotherapy, 6 weeks from mitomycin, and nitrosourea treatment. if patients received anti-tumor biological products, at least four t1/2 of washout period is needed; * toxicity from previous treatment has to restore to ≤ grade 1 (nci ctc4.0); * ecog performance status 0-1; * life expectancy ≥ 3 months; * adequate hematologic function: anc ≥ 1.5 × 10\^9 /l, hb ≥ 90 g /l (blood transfusion allowed), plt ≥ 100 × 10\^9 /l; * adequate hepatic function: alt ≤ 2.5 × uln, ast ≤ 2.5 × uln, tbil ≤ 1.5 × uln (patients with liver metastases alt ≤ 5 × uln, ast ≤ 5 × uln, tbil ≤ 3 × uln); * adequate renal function: creatinine ≤ 1 × uln; * coagulation function: inr ≤ 1.5 × uln, aptt ≤ 1.5 × uln; * patients of childbearing potential (male and female) must agree to use reliable methods of contraception until at least 12 weeks after the last dose. exclusion criteria: * hcv, tp or hiv antibody positive; * previously received anti-vegf protein drugs, such as bevacizumab; * histologically proven squamous cell lung cancer or squamous cell carcinoma of the head and neck; * active hepatitis b infection; * evidence of serious infection; * symptomatic brain metastases; * patients with proteinuria at screening (urine protein ≥ 1+); * history of abdominal fistula, gastrointestinal perforation, abdominal abscess within 6 months prior to enrollment; * serious non-healing wounds, ulcers or fractures; * major surgery (excluding biopsy) or significant trauma within 4 weeks prior to enrollment; * active bleeding within 3 months prior to enrollment; * bleeding diathesis or coagulation disorder; * history of arterial or venous thrombosis; * history of myocardial infarction or stroke within 6 months prior to enrollment; * unstable angina, congestive heart failure, new york heart association (nyha) class ii heart failure, uncontrollable arrhythmia, uncontrolled hypertension (systolic blood pressure\> 150 mmhg and/or diastolic blood pressure\> 100 mmhg); * pregnant and lactating women; * known allergies to any excipient in the study drug; * patients with alcohol or drug dependence; * participation in other clinical trials within 4 weeks before enrollment.
virtual reality for pediatric palliative care team

Conditions: Occupational Stress

Summary: is virtual reality a useful and usable tool to improve the psychological well-being of ppc operators? study primary obtv: assessment of occupational psychological well-being (divided into stress, depression, anxiety and risk of burnout) in the population of health professionals working in pediatric palliative care; verify if the virtual reality tool leads to an improvement change at the level of the investigated items (feasibility study). the treatment will have a duration of 4 weeks, with the execution of two sessions per week with the use of a viewer positioned on the head that allows users to navigate and interact in real time with a three-dimensional (3d) environment at time zero (t0), the participants will be administered, shortly before the application of virtual reality, the mini-z survey 2.0 questionnaires (the single item burnout question), depression anxiety stress scales 21 (dass-21), and a demographic questionnaire (gender, age, profession, shift work, years of work in ppcs). at the end of the compilation, two vision treatments will follow, which will take place three to four days apart. at time t1 (second week) and time t2 (third week) the dass-21 will initially be administered followed by two weekly treatments with a visor. at the end (t3) the compilation of both tests (mini-z survey 2.0-the single item burnout question and the dass-21) will be repeated following the last two applications of the viewer.


Eligibility criteria:
inclusion criteria: * work within the pediatric hospice of padua * absence of neurological pathologies * personnel who actively engage in membership/participation during all 4 weeks of the project exclusion criteria: * subject do not sign written consent

Keywords: virtual reality pediatric palliative care anxiety burnout
fabry and stroke epidemiological protocol (fasep): risk factors in ischemic stroke patients with fabry disease

Conditions: Cerebrovascular Accident; Stroke, Acute; Cerebral Stroke

Summary: more than one million people in europe suffer from a stroke every day. normally older people have a stroke, but also a significant number of younger people between 18 and 55 years. usually, these can only be explained for a minority by the classical risk factors such as diabetes, overweight and high blood pressure. new studies indicate that in about 1 - 2 % of the younger stroke patients the etiology can be an undiagnosed genetic disease, e.g. fabry disease. fabry disease is a lysosomal storage disorder known to cause vasculopathy. the purpose of this study is to determine in a large number of young stroke patients, how many strokes were caused by fabry disease and what risk factors might be able to predict this disease.


Eligibility criteria:
inclusion criteria: * adult patients (18 - 60 years of age) with an acute ischemic cerebrovascular event either acute ischemic stroke or transient ischemic attack within 10 days * diagnosis of the cerebrovascular event (cve) by a stroke experienced physician * diagnostic procedures for cve according to the local guidelines and recommendations * written informed consent from patient or legal representative according to local regulations exclusion criteria: * patients being younger than 18 years or older than 60 years of age. * acute ischemic stroke or transient ischemic attack longer than 10 days before enrollment into the study * cve associated with intracranial hemorrhage as evidenced by cerebral ct scan * any uncertainty in the diagnosis * no written informed consent from the patient or legal representative

Keywords: cerebrovascular accident cerebrovascular accident, acute fabry disease fabry´s disease anderson-fabry disease cva (cerebrovascular accident) stroke, acute cerebral stroke
smartphone addiction and temporomandibular dysfunction

Conditions: Smartphone Addiction

Summary: the aim of this study was to investigate the effect of smartphone addiction on temporomandibular dysfunction with the determinants of pain threshold, head posture and neck disability level.

firstly, the purpose of the research and the evaluation methods were explained to the students. students who volunteered to participate in the study and met the inclusion criteria were included in the evaluation. approval was obtained from the evaluated students with the 'informed voluntary consent form'. then, the students will fill in the descriptive data form. the risk of smartphone addiction of the students who filled out the descriptive data form was assessed with the smartphone addiction scale-short form, tmd dysfunction status was assessed with the fonseca anamnestic index, neck disability status was assessed with the neck disability index, tmj pain was assessed with the numeric pain scale, head posture was assessed with a goniometer, and pressure pain threshold of the tenar and masseter muscles was assessed with an algometer. the evaluations took an average of 45 minutes for each student. the evaluations of the students were performed only once.

Eligibility criteria:
inclusion criteria: * to study at bandirma onyedi eylül university * students between the ages of 18-30 years, whose voluntary consent was obtained and who use smartphones exclusion criteria: * individuals undergoing masseter botox application * individuals diagnosed with tmj disorder and/or bruxism * individuals with musculoskeletal system problems such as fractures of the hand, fingers, upper extremities and/or tmj, rheumatoid disease with evidence of systemic, specific pathological conditions * individuals who have undergone any surgical operation related to hand, finger, upper extremity and/or tmj problem * individuals who have received hand, finger, upper extremity and/or tmj-related physiotherapy and rehabilitation services in less than 6 months * individuals with facial paralysis * individuals with diagnosed psychiatric illness.

Keywords: smartphone addiction temporpmandibular disorders head posture pain