Kornimate/medical-research-clean huggingface dataset:
acthar gel in participants with pulmonary sarcoidosis

Conditions: Sarcoidosis, Pulmonary

Summary: the purpose of this study is to find out if acthar gel is safe and effective to treat pulmonary sarcoidosis. participants will be randomly assigned (like flipping a coin) to receive a shot under their skin of acthar gel or a matching placebo gel that has no drug in it. they will receive their assigned shot twice a week for 24 weeks. all participants who complete the 24-week treatment period will be eligible to receive acthar gel for 24 more weeks, even if they were originally in the placebo group.


Eligibility criteria:
inclusion criteria: * has biopsy-confirmed sarcoidosis meeting american thoracic society criteria ≥ 1 year at screening (visit 1) * has protocol-defined symptomatic pulmonary disease * has been receiving a stable prednisone dose between 5 mg and 40 mg (or equivalent) for pulmonary sarcoidosis, for at least 4 weeks before screening, or a stable dose of another disease-modifying anti-sarcoidosis drug for at least 3 months before screening * has lung function within protocol-defined parameters exclusion criteria: * has at least a 10% change in forced vital capacity (fvc) on spirometry between visits 1 and 2 * has pulmonary arterial hypertension requiring treatment * has been treated with antitumor necrosis factor-α antibody within the past 3 months * has any pulmonary condition that requires treatment, therefore impeding corticosteroid tapering
permeaderm® vs. mepilex-ag® in promoting healing of partial-thickness burn wounds

Conditions: Partial-thickness Burn

Summary: the purpose of this study is to compare the effectiveness of the wound dressings currently used at our institution for partial-thickness burn wounds: permeaderm® (permeaderm, inc., carlsbad, california, usa) and silver impregnated foam dressing (mepilex ag®, health care, göteborg, sweden)

in this prospective, randomized parallel study, the effectiveness of the wound dressings currently used at our institution for partial-thickness burn wounds will be compared: permeaderm®, and silver coated foam dressing mepilex ag®.this study is therefore considered a minimal risk study. procedures related to research apart from randomization to one of the dressings, will include review of medical records, non-invasive wound and scar assessments and additional photographs. 60 patients with partial thickness burns meeting the inclusion criteria of the study will be enrolled to receive either permeaderm® (n=30) or silver coated foam dressing (mepilex ag®; n=30) in an outpatient or observational setting. prior to placement of wound dressings, baseline assessments of wound size and burn depth will be performed by the experienced physician and documented using photography and when indicated laser doppler (moor laser speckle®, moor instruments, devon, uk) measurements. time to heal will be defined as the time after which complete re-epithelialization is reached and permeaderm® detaches or there are no more changes of mepilex ag® needed. secondary goals of the study are to assess pain, and scarring associated with the use of the different dressings in our burn patients, as well as to assess cost-effectiveness of the therapy. pain will be assessed at every patient visit using visual analog scale (vas) or wong-baker faces respectively; mid and long-term scar development is assessed at approximately 1 and 6 months after enrollment in the study using patient and observer scar assessment scale (posas) and dermalab combo® (cortex technology, denmark).

Eligibility criteria:
inclusion criteria: * superficial partial thickness burn injury due to flame burn, scald injury or contact burn that does not require excision and grafting * total body surface area burned (tbsa) total ≤30 % * admission within 72 hours of burn injury * non-infected wound as diagnosed by the attending physician upon admission * treated as an outpatient or in an observational setting exclusion criteria: * patient younger than 6 months * causes other than contact burn, flame or scald injuries (i.e., electrical, chemical or frostbite) * admission time greater than 72 hours after the injury * wounds noted to be infected at admission * previous treatment efforts such as previous debridement, silver sulfadiazine ointment or other pseudo eschar-forming topical agents * pregnancy/lactation

Keywords: permeaderm, mepilex ag, partial thickness burn wounds
resolvin d1 levels in patients with periodontitis

Conditions: Periodontitis

Summary: the purpose of the study was to determine the levels of resolvin d1 (rvd1) in the gingival crevicular fluid (gcf) and saliva of the patients with periodontitis (p) and also to investigate the effects of non-surgical periodontal treatments (nspts) on its levels. a total of 26 subjects (15 p, 11 healthy) were included. clinical periodontal measurements, gcf and saliva samples were collected from each individual at baseline and 1 month after nspts in p group. rvd1 levels were determined by enzyme-linked immunosorbent assay (elisa) method.


Eligibility criteria:
inclusion criteria: * stage 3, grade b and generalized periodontitis patients exclusion criteria: * excessive forces; * presence of systemic diseases * administration of non-steroidal and anti-inflammatory drugs or antibiotic therapies within the previous 6 months * having received non-surgical periodontal treatment within the past 6 months * allergy or sensitivity to any drug, * pregnancy, lactation * current and former use of tobacco.

Keywords: gingival crevicular fluid resolvin d1
efficacy study of bromfenac ophthalmic solution in patients undergoing cataract surgery

Conditions: Pain; Inflammation

Summary: efficacy study of bromfenac ophthalmic solution in cataract surgery


Eligibility criteria:
inclusion criteria: * male or female at least 18 years of age who are scheduled for unilateral cataract surgery exclusion criteria: * have known hypersensitivity to bromfenac or to any component of the investigational product

Keywords: pain and inflammation as a function of cataract surgery
diagnostic value of 18f-fluoride-pet/mri in the management of suspected facet joint arthropathy

Conditions: Arthropathy of Lumbar Facet; Pain, Back

Summary: prior to the injection, the facet joints have to be defined according to standard radiological techniques (e.g. mri and physical correlation). patients are then sent to 18f-fluoride-pet/mri imaging, in order to localize facet joints with increased uptake. facet joints to be injected are again defined according to the location(s) of highest uptake as demonstrated by 18f-fluoride-pet/mri. the defined injection sites before and after pet/mri are compared. in equal defined injection sites, patients are sent for infiltration as scheduled, otherwise patients are randomized into two groups. one group will undergo facet injection(s) according to the 18f-fluoride-pet/mri result, with standard injections performed under ct-guidance by the radiology department of the study site. the control group will undergo facet injections blinded to the 18f-fluoride-pet/mri results, but based on current standard clinical practise (mri and clinical correlation). the patients are asked to complete a validated pain and function questionnaire immediately before the facet joint injection, at 15 minutes, 1 day, 1 week and 1 month after the injection, as performed routinely in our institution. the purpose of this study is to prospectively evaluate the value of 18f-fluoride-pet/mri imaging in patients with low back pain with evidence of painful facet joint arthropathy, which would potentially benefit from facet joint injections.


Eligibility criteria:
inclusion criteria: 1. patients over 18 years old with low back pain who have failed conservative management in the primary care setting, namely, analgesia and physical therapy. 2. imaging evidence (e.g. mri) of facet joint degeneration, such as facet hypertrophy, subchondral sclerosis, and joint space narrowing. 3. obtained informed consent exclusion criteria: 1. had undergone prior spinal surgery or prior facet joint injections or 2. had other spinal abnormalities (benign or malignant tumors, congenital defects, isthmic spondylolisthesis) or 3. are unable to tolerate pet/mri imaging 4. are pregnant or nursing.
fluorouracil in treating patients with recurrent or metastatic bladder cancer

Conditions: Bladder Cancer; Transitional Cell Cancer of the Renal Pelvis and Ureter; Urethral Cancer

Summary: rationale: drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. purpose: phase ii trial to study the effectiveness of fluorouracil given as a continuous infusion in treating patients with recurrent or metastatic bladder cancer.

objectives: i. determine the response rate and toxic effects of continuous fluorouracil in patients with recurrent locally advanced or metastatic transitional cell urinary tract carcinoma. ii. determine the feasibility of this treatment in this patient population. outline: patients receive continuous intravenous fluorouracil by a baxter infusor for 24 weeks. patients are evaluated for complete and partial response at 8, 16, and 24 weeks after the start of intravenous fluorouracil. patients experiencing disease progression or unacceptable toxic effects are removed from the study. patients are followed monthly for 6 months post treatment. projected accrual: a maximum of 45 patients will be accrued.

Eligibility criteria:
disease characteristics: histologically proven recurrent locally advanced or metastatic transitional cell urinary tract carcinoma that has been previously untreated with systemic chemotherapy pelvic relapse after radiotherapy or surgery no relapse solely within a previously irradiated field nodal or metastatic disease lesions within the abdomen or pelvis must be assessed using ct scanning at least one site of disease must be previously unirradiated and assessable for response bone metastases cannot be used as an indicator lesion measurable disease patient characteristics: age: not specified performance status: not specified life expectancy: not specified hematopoietic: wbc at least 3,500/mm3 platelet count at least 100,000/mm3 hepatic: not specified renal: glomerular filtration rate at least 50 ml/min creatinine clearance at least 25 ml/min prior concurrent therapy: biologic therapy: not specified chemotherapy: no prior systemic chemotherapy endocrine therapy: not specified radiotherapy: see disease characteristics surgery: see disease characteristics

Keywords: recurrent bladder cancer transitional cell carcinoma of the bladder recurrent urethral cancer recurrent transitional cell cancer of the renal pelvis and ureter
inspiratory muscle training in patients with end stage renal failure

Conditions: Renal Failure; Chronic Renal Insufficiency

Summary: this study will investigate whether inspiratory muscle training in patients with end stage renal failure can improve strength and function.

patients with chronic renal failure commonly have weak respiratory muscles leading to problems in everyday activities and respiratory infections. this project aims to investigate if threshold inspiratory muscle training improves the strength, everyday function and participation of patients on haemodialysis. forty eight patients will be recruited in a randomized controlled trial of inspiratory muscle training vs sham training. outcome measures include the maximal inspiratory pressure and the frenchay activities index. initial data will be collected by a blinded assessor; the patients will train at 40 % of initial maximal inspiratory pressure for six weeks and be reassessed. if the inspiratory muscle training is effective, it will improve both the physical and functional components of the patient's lives and be recommended for all renal patients.

Eligibility criteria:
inclusion criteria: * documented chronic renal failure * attending either haemodialysis or pre-dialysis clinic * age 18 * english speaking * no prior experience with inspiratory training devices. exclusion criteria: * lung collagen disorders * renal diseases associated with autoimmune pulmonary diseases * current pleural effusion * pulmonary oedema * decreased conscious level * behavioural disturbances * unable or refused to give consent * taking medications that influence respiratory muscle function (e.g. steroids or cyclophosphamide)

Keywords: renal failure respiratory muscles resistance training
evaluation of diaphragm in chronic obstructive pulmonary disease patients by ultrasound in relation to severity

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the study of the diaphragm is an important point in the assessment of copd patients. ultrasonographic evaluation of the diaphragm is considered a simple, non-invasive, available bedside technique. ultrasonography can be used for evaluation of the site, structure, and motion of the diaphragm, assessment of excursion, and thickness. the aim of the study is ultrasonographic assessment of the diaphragm in copd patients and its relation to disease severity

the study was conducted on eighty patients, forty copd patients who were diagnosed and classified into four groups according as following: the first group: included 10 patients with a mild stage. the second group: included 10 patients with a moderate stage. the third group: included 10 patients with a severe stage. the fourth group: included 10 patients with a very severe stage. the study also included forty healthy individuals of the same age and sex as copd patients. all participants gave their informed consent for inclusion before sharing in the study. every person was submitted to: full medical history, clinical examination,chest x-ray, spirometry and ultrasonographic assessment of diaphragm function (thickness and excursion)

Eligibility criteria:
inclusion criteria: * • stable copd patients aged more than 40 years who were diagnosed and classified into four groups of severity according to gold 2020. * age and sex-matched healthy controls exclusion criteria: * • patient with a known neuromuscular disorder. * patient with known anatomical malformation of the diaphragm. * post abdominal or thoracic surgery.

Keywords: ultrasonography, diaphragm, copd, fayoum
the effect of care given using levine's conservation model on postpartum quality of life in primiparas

Conditions: Breastfeeding; Quality of Life; Nursing Caries; Postpartum; Nursing Model; Levine Conservation Model

Summary: background: postpartum period is a physiologically, emotionally and socially critical period for the woman who gave birth and also for their family. in order for women to go through their postpartum period without any problems, be able to perform self-care and have an unaffected quality of life, they need qualified, comprehensive and integrative nursing care. aim and objectives: this study aimed to investigate the effect of care given using levine's conservation model on postpartum quality of life in primiparae. design: a randomized controlled trial. methods: levine's conservation model was used as the theoretical framework for this study. a literature review was used to determine the contents of the intervention program. the program consisted of 8 sessions. the puerpera were given trainings on different subjects based on the module during each session. for these trainings, the researcher prepared, in the light of the literature data, leaflets containing information about breastfeeding, personal hygiene, fatigue, nutrition and pilates exercises. the puerpera in the control group received only the standard nursing care given after birth. standard nursing care contain solely breastfeeding training.


Eligibility criteria:
the study included puerpera who * were in the 18-35 age interval and were at least a primary school graduate, * had no loss of their senses of vision or hearing, * were open to communication and cooperation, * had a nuclear type of family, * were able to understand and read turkish, * were primiparae, * had a full-term (between weeks 38-42) vaginal delivery, * had a haemoglobin value of at least 10 mg/dl, * experienced no risky conditions during gestation (placenta previa, pre-eclampsia, any systemic ailment) or during delivery (ablatio placenta, dystocia, etc.), * were administered mediolateral episiotomy (because episiotomy impair the integrity of tissue. healing such episiotomy incisions as soon as possible is quite important to conserve structural integrity). exclusion criteria: - those who do not meet the eligibility criteria

Keywords: nursing care levine's conservation model postpartum care postpartum quality of life postpartum problems
a single arm trial with resolute onyx in one-month dapt for high-bleeding risk patients who are considered one-month clear (onyx one clear)

Conditions: Coronary Artery Disease

Summary: the purpose of this trial is to evaluate the clinical safety and effectiveness of the resolute onyx stent in subjects deemed at high risk for bleeding and/or medically unsuitable for more than 1 month dapt treatment receiving reduced duration (1 month) of dapt following stent implantation.


Eligibility criteria:
inclusion criteria: to qualify as high-bleeding risk and/or a candidate for 1-month dapt, subject had to meet at least one of the criteria detailed below: * adjunctive chronic oral anticoagulation treatment planned to continue after pci * age ≥ 75 years old * baseline hgb \<11 g/dl (or anemia requiring transfusion during the 4 weeks prior to procedure) * any prior documented intracerebral bleed * any documented stroke in the last 12 months * hospital admission for bleeding during the prior 12 months * active non-skin cancer currently undergoing treatment or surveillance (in lieu of treatment) * planned daily nsaid (other than aspirin) or steroids for ≥30 days after pci * planned surgery that would require interruption of dapt (within the next 12 months) * renal failure defined as: creatinine clearance \<40 ml/min * thrombocytopenia (plt \<100,000/mm3) * severe chronic liver disease defined as: subjects who have developed any of the following: variceal hemorrhage, ascites, hepatic encephalopathy or jaundice * expected non-compliance for at least 6 months dapt for other medical reasons exclusion criteria: * pregnant and breastfeeding women * subjects requiring a planned pci procedure after 1 month of index procedure * procedure planned to require non-trial stents, stand-alone poba, or stand-alone atherectomy * active bleeding at the time of inclusion * cardiogenic shock * subject with planned surgery or procedure necessitating discontinuation of dapt within one month following index procedure * subject not expected to comply with long-term single antiplatelet therapy * a known hypersensitivity or contraindication to aspirin, heparin and bivalirudin, p2y12 inhibitors, mtor inhibiting drugs such as zotarolimus, biolimus a9 (or its derivatives), cobalt, nickel, platinum, iridium, chromium, molybdenum, polymer coatings (eg, biolinx™), stainless steel (or other metal ions found in 316l stainless steel), zinc, or a sensitivity to contrast media, which cannot be adequately pre-medicated. * pci during the previous 6 months for a lesion other than the target lesion of the index procedure * participation in another clinical study within 12 months after index procedure * subjects with life expectancy of less than 2 years
intelligent evaluation and supervision of cataract surgery

Conditions: Cataract

Summary: research purpose: intelligent identification and evaluation of cataract surgery steps research methods: a total of 9 items (such as gender, age, visual acuity, etc.) were extracted from the surgical videos of senile cataract patients and the clinical data recorded by the electronic medical record system. the machine learning algorithm 3d-cnn was applied to identify the 11 steps in cataract surgery and the pictures (blank pictures) without instrument manipulation on the eyeball during the operation. six key cataract surgery steps were scored using deep learning algorithms (probability smoothing window and softmax). we employ precision, precision, recall, and f1-score to evaluate the model's performance for recognizing surgical steps. to evaluate the reliability of the model's scoring of surgical steps, we used a human-machine comparison method to calculate the agreement (kappa value) between machine and expert scores.


Eligibility criteria:
inclusion criteria: -videos of phacoemulsification and iol implantation for senile cataracts will be included exclusion criteria: -the peak signal-to-noise ratio (psnr) is utilized to assess whether a video was blurred. if the psnr of a video was less than 20 decibels (dbs), the whole video was discarded.

Keywords: cataract surgery
prevalence of bacteria following endodontic treatment

Conditions: Root Canal Infection

Summary: sampling of accessed root canals with endodontic paper points during treatment and immediately pre-obturation of endodontic root canals was carried out.

following ethical approval (rec ref: 05/q0705/051), informed consent was obtained from patients undergoing root canal treatment.the teeth included in the study had been referred to a specialist centre for the treatment of endodontic infection. they all responded negatively to vitality tests and presented pre-operative apical radiolucencies. the source population were referred by their general dental practitioner into specialist endodontic clinics of guy's hospital, king's college london dental institute.treatments on the teeth were carried out by a total of 19 postgraduate endodontic students.

Eligibility criteria:
inclusion criteria: * patients with single or multi-rooted teeth undergoing root canal treatment. exclusion criteria: * for certain aspects of the study secondary treatments and vital teeth are excluded.

Keywords: bacteria root canal treatment endodontics