Kornimate/medical-research-clean huggingface dataset:
the effect of carer training on pressure ulcers in palliative patients

Conditions: Public Health Nursing

Summary: the aim of this article is to examine the effect of the training of carers caring for palliative care patients on the prevention and management of pressure ulcers. in this context, how the training affects the level of knowledge and practices of the carers will be evaluated. the findings obtained will contribute to improving the quality of patient care by providing strategic recommendations for the improvement of palliative care services.

palliative care is an approach that improves the quality of life of patients and their families facing problems related to life-threatening diseases. this care model focuses on meeting the physical, psychological, social and spiritual needs of patients. . pressure ulcers are one of the most common and serious problems in palliative care. pressure ulcers are injuries occurring on the skin or soft tissue. they develop due to pressure on certain parts of the body over a long period of time. if not treated immediately, they may cause fatal complications. pressure ulcers affect more than 1 in 10 adult patients admitted to hospital and are highly preventable. most palliative care patients cannot provide self-care. therefore, caregivers are one of the most important determinants of the patient's health status. at this point, the knowledge and skill levels of carers who provide direct care to patients are of great importance. increasing the level of knowledge and awareness of caregivers to prevent pressure ulcers is a critical strategy to prevent the formation of these wounds and to accelerate the healing of existing wounds. in a systematic review of thirty-one articles, it was stated that pressure ulcers significantly limit many aspects of an individual's well-being, including mental and physical health and quality of life. therefore, caregivers should have adequate knowledge about practices to prevent bedsores. the aim of this article is to examine the effect of the training of carers caring for palliative care patients on the prevention and management of pressure ulcers. in this context, how the training affects the level of knowledge and practices of the carers will be evaluated. the findings obtained will contribute to improving the quality of patient care by providing strategic recommendations for the improvement of palliative care services.

Eligibility criteria:
inclusion criteria: * over 18 years of age * being the sole informal caregiver of the palliative care patient * being able to use physical abilities such as sight and hearing * no cognitive and communication problems exclusion criteria: * palliative care patient is not the only informal caregiver * cognitive and communication problems

Keywords: palliative care pressure ulcers
comparing the safety and cosmetic outcomes between laparoscopic versus traditional open breast-conserving surgery

Conditions: Breast Cancer

Summary: in recent years, laparoscopic breast cancer surgery has received wide attention. it has advantages of minimal invasiveness, clear anatomical exposure, and good aesthetic effects. based on these advantages, we propose whether laparoscopy is suitable for breast-conserving surgery for breast cancer. the standard procedure of laparoscopic breast-conserving surgery is unclear. more high-quality clinical studies are required. therefore, we intend to conduct a multi-center, open, productive, randomized controlled study comparing the safety and cosmetic effects of endoscopic breast-conserving with traditional open breast-conserving surgery.

in recent years, laparoscopic breast cancer surgery has received wide attention. it has advantages of minimal invasiveness, clear anatomical exposure, and good aesthetic effects. based on these advantages, we propose whether laparoscopy is suitable for breast-conserving surgery for breast cancer. the standard procedure of laparoscopic breast-conserving surgery is unclear. more high-quality clinical studies are required to ensure the efficiency of cure. also, less scars and breast preservation has becoming more and more important for patients' acceptance to the treatment. therefore, we intend to conduct a multi-center, open, productive, randomized controlled study comparing the safety and cosmetic effects of endoscopic breast-conserving with traditional open breast-conserving surgery.

Eligibility criteria:
inclusion criteria: * female over the age of 18 * preoperative pathologically confirmed invasive breast cancer or ductal carcinoma in situ * clinical classification t1, t2 (maximum tumor diameter ≤5cm) * single-center tumor (preoperative confirmation by b-ultrasound, mri and other imaging examinations) * no clinical or imaging evidence of distant metastasis * able and willing to sign informed consent exclusion criteria: * tumor in the lower inner quadrant * tumor in multiple quadrants * imaging or intraoperative pathology indicates tumor invasion of the nipple areola, skin, or pectoralis major * locally advanced breast cancer patients are undergoing neoadjuvant therapy * tumor in multiple quadrants * have been participating in other clinical trials, which may affect the participation in this trial * previous history of breast cancer (patients with recurrence after ipilateral breast-conserving surgery) * pregnant and lactating women * patients with severe cardiopulmonary disease or severely impaired lung function are not suitable for surgical establishment of an air cavity

Keywords: breast cancer
microscopic images for the development of a rapid vaginitis diagnostic device

Conditions: Vaginitis

Summary: the study goal is to create an archive of microscopy images of various vulvovaginal inflammation conditions

during the study, the investigators are planning to make a secondary use of vaginal discharge samples that are primarily taken for routine wet mount microscopic diagnostics in a vulvovaginal clinic at the women's health center, ramat-eshkol, jerusalem. in order to create an anonymous archive of digital microscopy images, before each swab is disposed of, the investigator will dilute the collected discharge on the swab with 0.5ml saline into an eppendorf tube. the diluted discharge will then be applied onto the gyntools ltd vagx tray that is then scanned by a tabletop scanner. at this point the vagx tray will be washed with water, soap and both the swab and tube will be disposed of. no of participating patients: 1000 patients age: 18 years and above. only from patients capable of signing an informed consent.

Eligibility criteria:
inclusion criteria: vulvovaginal complaints exclusion criteria: younger than 18y or cannot sign an informed consent form
botulinum toxin-a as a treatment for chronic muscle-related pain in adults with spastic cerebral palsy: a randomized controlled trial

Conditions: Pain; Cerebral Palsy, Spastic

Summary: the purpose of this double-blinded, placebo-controlled study is to test if treatment with botulinum toxin-a is effective in reducing chronic muscle-related pain in adults with spastic cerebral palsy.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years. * spastic cerebral palsy. * chronic pain, related to spastic muscle. chronic pain defined as: 1)recurring regional pain for at least three months and 2)pain intensity on average for the last 24 hours ≥3 on numerical rating scale. * signed informed consent. exclusion criteria: * allergy/hypersensitivity to dysport® or any of its components. * pregnancy. * women who breastfeed their children. * treatment with botulinum toxin-a within the last five months. * if there has been dose changes in any muscle-tone altering medication within two weeks of visit 1. * a clear degenerative cause behind the pain as elucidated by the clinical examination (e.g. history of osteoarthritis). * intellectual disability and/or communication impairment that disable the individual from answering the questionnaires and giving informed consent.

Keywords: randomized controlled trial placebo controlled double blinded botulinum toxin type a adults pain spasticity cerebral palsy, spastic dysport
optimal surgery and mri based radiochemotherapy in rectal carcinoma

Conditions: Rectal Cancer Stage II; Rectal Cancer Stage III

Summary: the objective of the study is to provide proof that a mri based preoperative radiochemotherapy in patients with locally advanced rectal carcinoma allows limiting rct to high risk patients without increase of locoregional recurrence rate and decrease of overall survival provided there is a high quality of mesorectal excision.

the criteria for application of rct is the distance of the tumor from mesorectal fascia in preoperative mri of the pelvis. in case of a t 4 tumor or a tumor with a distance of 1mm of less form mesorectal fascia long-course radiochemotherapy is applied followed by surgery, in all other cases primary surgery is done.

Eligibility criteria:
inclusion criteria: * patients with histologically confirmed invasive carcinoma of the rectum infiltrating beyond the submucosa (ct3, ct2n+, cm0) * elective surgery * fit for surgery * preoperative mri of pelvis exclusion criteria: * ut1 tumors * provided for local excision * previous or synchronous malignant tumors (except squamous and basal cell carcinoma of the skin and carcinoma in situ of the cervix) * previous irradiation of the pelvis * ulcerative colitis or crohn's disease

Keywords: rectal cancer mri selective preoperative radiochemotherapy involvement of circumferential resection margin locoregional recurrence rate
diacutaneus fibrolysis on tempromandibular joint pain and trismus post oral surgery

Conditions: Temporomandibular Pain

Summary: this study is carried out on sixty patients who will have tempromandibular pain and trismuspostoral and maxillofacial surgeryand their ages will be ranged from 18 to 40 years.


Eligibility criteria:
inclusion criteria: 1. ages of patients will be ranged from 18 to 40 years. 2. all patients will have oral and maxillofacial surgery. 3. all patients will be referred by a surgeon before starting the study procedure. 4. all participants will have pain and trismus in the jaw, 5. the participants will be also cleared for periodontal issues. 6. all patients will enter the study having their informed consent exclusion criteria: 1. patients with associated vascular injuries requiring arterial repair. 2. patient with systemic diseases such as arthritis; pain attributable to confirmed migraine, head, or neck pain condition 3. patient with acute infection or other significant disease of the teeth, ears, eyes, nose, or throat 4. patient with present neurologic or cognitive deficit. 5. patients with history of previously failed surgeries.
examining the incidence of oral human papillomavirus (hpv) shedding and oral warts after beginning haart in hiv-infected adults

Conditions: HIV Infections

Summary: oral human papillomavirus (hpv) and oral warts are common health concerns for hiv-infected people. this study will examine the frequency of oral hpv dna shedding and oral warts in hiv-infected people who are enrolled in actg a5257 and who are beginning treatment with highly active antiretroviral therapy (haart).

oral hpv infection occurs at a higher rate among hiv-infected people than among the general population. recent research in the united states and europe has also found that hiv-infected people have a higher risk of oral and oropharyngeal squamous cell cancer than hiv-uninfected people. in one study, it was found that hpv seropositivity was associated with an increased risk of squamous cell carcinoma of the oropharynx (sccop). in addition to sccop, another hpv-related health concern is oral warts, a condition for which there is no effective treatment. even after beginning treatment with highly active antiretroviral therapy (haart), active hpv replication in the mouth and oropharynx may persist in hiv-infected people, leading to an increased risk of sccop and oral warts. the purpose of this study is to evaluate the frequency of oral hpv dna shedding and oral warts in hiv-infected people prior to haart initiation and at regular time points after haart initiation. actg a5257 is a study that is comparing the effectiveness of three non-nucleoside reverse transcriptase inhibitor (nnrti)-sparing haart regimens in treatment-naïve participants. this study will enroll participants from the actg a5257 study. participants will attend a baseline study visit at the same time as their actg a5257 baseline study visit. at baseline and at week 4, 16, 24, and 48 study visits, participants will undergo an examination of their mouth, throat wash and saliva collection, and behavioral questionnaires. a blood collection will also occur at week 24.

Eligibility criteria:
inclusion criteria: * meet inclusion criteria for and be enrolled in actg a5257 * ability and willingness of participant or legal guardian/representative to provide informed consent exclusion criteria: * co-enrollment in a5260s * has begun receiving haart as part of the a5257 study * has ever received an hpv vaccine or plans to receive an hpv vaccine in the 6 months after study entry
breast cancer with over-expression of erbb2-brainstorm

Conditions: Cancer

Summary: this retrospective cohort study aims to improve our understanding of the current paradigm for treatment of brain metastases in erbb2+ breast cancer patients in the asia pacific region. we aim to identify approximately 300 erbb2+ breast cancer patients with brain metastases diagnosed between 2006-2008 in 6 countries. medical records will be analyzed to determine the treatment pattern for brain metastases, including anti-erbb2 therapy. additional objectives are to understand the impact of anti-erbb2 therapy on survival after brain metastases and to investigate the relationship between anti-erbb2 therapy for brain metastases and: 1) the time interval between diagnosis of erb2+ breast cancer and brain metastasis, and 2) the occurrence of brain metastasis as the first site of disease progression.


Eligibility criteria:
inclusion criteria: 1. female patients diagnosed with erbb2+ breast cancer. erbb2 positivity will be as determined by respective institutional standards, and will be based on medical history only. 2. brain metastasis diagnosis made between january 2006 - december 2008. exclusion criteria: 1. women who have another primary cancer diagnosed between the time of breast cancer diagnosis and brain metastasis.. 2. patient has leptomeningeal metastases only without parenchymal brain involvement (since this pattern of the disease requires a different treatment approach.)

Keywords: erbb2+ breast cancer erbb2 treatment brain metastases
parent program to improve child behavior problems

Conditions: Child Behavior Problems

Summary: the purpose of this research study is to learn whether or not a brief parenting program called child adult relationship enhancement (care) offered at a primary care office can help improve behavior problems in children who are 2-6 years old.

the study will be a randomized controlled trial (rct) of the care intervention. the study will include 2-6 year old children who receive their primary care at the children's hospital of philadelphia, south philadelphia primary care clinic and whose caregiver and/or doctor has concern about a behavior problem in the child. the caregivers will also be subjects in the study. child-caregiver pairs who agree to be in the study will be randomly assigned to receive the care training immediately or in 3-4 months. the care intervention will last 6 weeks and child behavior and parenting will be measured at baseline, 6-8 weeks, and 14-18 weeks. investigators will also measure parent satisfaction with the care intervention. * child adult relationship enhancement (care) is a group parent training program. * the goals of the program are to teach parents skills that help their children successfully reach developmental milestones while increasing positive behaviors. * the program also was designed to help parents manage and decrease negative child behaviors. * each training will be led by 2 therapists and 4-10 parents will attend the care program together. * children do not attend the training but parents are encouraged to practice the skills learned at care between the sessions.

Eligibility criteria:
inclusion criteria: 1. caregiver is 18 years or older 2. caregiver is english speaking 3. child is 2-6 years old 4. caregiver reports that child has a behavior problem 5. child attends chop south philadelphia primary care for primary care 6. parental/guardian permission is provided (informed consent) exclusion criteria: 1. child has a cognitive age less than 2 years old as determined by the referring clinician 2. child is already receiving behavioral health therapy or medication (other than medication for attention deficit hyperactivity disorder)

Keywords: child behavior problems parent training program
pelvic floor muscle training(pfmt) on lower urinary tract symptoms (luts) in men with stroke

Conditions: Male; Stroke; Urinary Incontinence

Summary: the aim of this study is to evaluate the effect of pelvic floor muscle training (pfmt) on lower urinary tract symptoms (luts) in men after stroke. 120 men with luts or increased luts after stroke is included and randomized into a treatment group or a control group. the subjects in the treatment group follows a 12 week standard pfmt program, while the control group is not given specific treatment of their luts but like the treatment group follows the standard rehabilitation program for stroke patient. outcome are measured by * 5 questionnaires * voiding diary * 24-hour pad test * pelvic floor muscle assessment test


Eligibility criteria:
inclusion criteria: 1. men, diagnosed with stroke clinical defined according world health organisation (who 1989) and confirmed by ct and mri scan 2. onset of last stroke ≥ 1 month 3. normal cognitive function (minimal mental examination score \> 25 ) (folstein, folstein et al. 1976). 4. luts according to ics definition (abrams, cardozo et al. 2002), with start or aggravation in close relation to the stroke 5. independent walking abilities indoor \> 100 m with/without aids 6. independence in toilet visits 7. age \> 18 years exclusion criteria: 1. prior history of luts surgery, pelvic surgery or trauma 2. more than 2 hospital diagnosed stroke 3. other severe neurological diseases including dementia 4. severe dysphasia 5. severe psychiatric disease 6. prostate cancer 7. do not speak danish or english

Keywords: pfmt stroke luts men
rhythmic stabilization versus ball balancing

Conditions: Spastic Cerebral Palsy (sCP)

Summary: spastic cerebral palsy (cp) is the leading cause of upper motor neuron syndrome (umn) in children. the primary factors contributing to motor behavior disorders in these children are impairments in motor control and muscle strength. these impairments result in changes in muscle growth and hinder the development of motor skills, leading to reduced muscle force generation and decreased flexibility. spastic cerebral palsy is the most prevalent type, affecting 77% of individuals with cp, and is caused by damage to the motor cortex and pyramidal tracts. the motor cortex is responsible for transmitting voluntary movement signals from the brain to the muscles. characteristics of spastic cerebral palsy include stiff muscles (hypertonia), which can cause jerky and repetitive limb movements (spasticity). additionally, individuals with cp often have difficulties in processing somatosensory and proprioceptive information. proprioceptive training refers to interventions aimed at enhancing proprioceptive function to ultimately improve motor performance, a concept that has been explored in studies focused on sports injuries. in this study, we will utilize two proprioceptive exercises-rhythmic stabilization and ball balancing-to promote functional improvement in the upper extremities of children with spastic cp.

there will be two groups: group a will consist of 16 patients undergoing rhythmic stabilization, while group b will also have 16 patients participating in ball balancing activities. data will be collected both before and after the intervention to determine the most effective approach. data analysis will be conducted using spss version 23.00. this study will be a randomized clinical trial, with data collected from the university of lahore teaching hospital (ulth) and the pakistan society for the rehabilitation of the disabled (psrd) in lahore. a total of 32 patients will participate, equally divided into two groups through random allocation. the inclusion criteria will consist of children aged 5-12 with spastic cp, encompassing both genders. patients with any neurological conditions, other orthopedic issues, a history of spine surgery, severe systemic disorders, psychiatric disorders, or neuromuscular disorders will be excluded from the study.

Eligibility criteria:
inclusion criteria: * spastic diplegic cp children age 6 to 12 years, * each gender included * grade 1 of spasticity according to modified ashworth scale (21) * with normal i.q. greater than 70 (assessed by psychologist), * can follow commands( exclusion criteria: * children with any other neurological impairment * children with audio visual impairment

Keywords: ball balancing corticobulbar tracts corticospinal tracts epilepsy rhythmic stabilization spastic cp
two treatment regimens of cocamide dea lotion for head lice

Conditions: Pediculosis; Head Louse Infestation

Summary: to assess the efficacy and safety of 10% cocamide dea using two treatment regimens in the eradication of head lice. to assess the ability of each treatment regimen to kill all viable ova and to assess patient acceptability of the product in use

a previous study found that a formulation of 10% cocamide diethanolamine (dea) aqueous lotion showed some efficacy to eliminate head louse infestation but that the treatment regimen was inadequate to kill all lice or louse eggs. this study has been designed to compare two different application regimens that have been shown effective in vitro. a planned total of 120 patients who, following examination, are found to suffer from active head lice infestation will be recruited to the trial. the patient will be treated with 10% cocamide dea lotion using the appropriate treatment regimen according to the randomization code from a pre-prepared listing in balanced blocks of 12. group 1: 10% cocamide dea is applied directly to dry hair, the excess water evaporated off using a hair dryer and is then left for 8 hour/overnight before washing off with clean water. group 2: 10% cocamide dea is applied directly to dry hair, the excess water evaporated off using a hair dryer and is then left for 2 hours before washing off with clean water. a follow up treatment is given after 7 days. treatments will be applied by experienced investigators throughout the study. assessments will be made by other investigators unaware of the treatment regimen used. after treatment (day 0), follow up assessments will be performed on days 4, 8,11 then again at day 14 after which they will leave the study. any adverse events or side effects from the treatments will be monitored during the study.

Eligibility criteria:
inclusion criteria: * male and female patients over the age of 4 who are found to have a head louse infection. * patients who give written informed consent and, if the patient is under 16 years of age, whose guardian gives written informed consent to participate in the study. * available for the duration of study i.e. 15 days. exclusion criteria: * patients with a known sensitivity to paraben preservatives. * patients who have been treated with other head lice products within the last 2 weeks. * patients who have undergone a course of antibiotic treatment within the last 4 weeks. * patients who have any persistent skin disorder of the scalp (i.e. eczema, chronic dermatitis, psoriasis). * patients whose hair has been bleached, colour treated or permed within the last 4 weeks. * patients who have participated in another clinical trial within 1 month prior to entry to this study. * patients who have already participated in this clinical trial.