Kornimate/medical-research-clean huggingface dataset:
mri-swi as a predictor of functional outcome in acute ischemic stroke

Conditions: Acute Ischemic Stroke; Stroke; Cerebral Stroke; Cerebrovascular Accident

Summary: the purpose of the study is to use diffusion tensor imaging (dti) derived axial diffusivity and susceptibility weighted imaging (swi) to evaluate the severity of acute ischemic stroke and to predict its functional outcome.

stroke is the second leading cause of death in taiwan. the morbidity and mortality of stroke is also very high worldwide. in the united states, about one third of 800,000 stoke patients became disabled; while in taiwan, 13,000 out of 68,000 stroke patients died each year. diffusion tensor imaging (dti) characterizes the three-dimensional distribution of water diffusion, which is highly anisotropic. previous studies utilized dti derived mean diffusivity (md) and fractional anisotropy (fa) have found correlation between pathological changes of white matter and prognosis of stroke. however, the result was not specific due to the reason that any change at either axon or myelin sheath resulted in fa reduction. dti, on the other hand, differentiate morphological change at axon and myelin sheath with axial and radial diffusivity, respectively. with this data, we hypothesized that the prognosis might be more relevant to pathological change with axon post-stroke when compare to diffusion-weighted imaging (dwi)/apparent diffusion coefficient (adc). susceptibility-weighted imaging (swi) is a newer technique which use fully velocity compensation gradient echo sequence to receive magnitude and phase imaging. swi can be used to detect early phase bleed, intra-arterial thrombus, cerebral venous thrombosis, thus evaluate the prognosis of patients by detect leptomeningeal collateral circulation and intravascular deoxygenation changes. we hypothesized that the prognosis is better in post-stroke patients with preserved leptomeningeal collateral circulation and venous circulation of large blood vessel. therefore, we conduct the study to use dti derived axial diffusivity and swi to evaluate the severity and to predict the functional outcome in acute ischemic stroke patient.

Eligibility criteria:
inclusion criteria: * age greater than 20 years * patients with acute pathological changes in cns within 7 days admitted from outpatient, er, or inpatient department * confirmed diagnosis of acute ischemic stroke by clinical testings and ct scan performed by a neurologist * signed informed consent from patient exclusion criteria: * any person with pacemaker, metal implant, claustrophobia, or any other contraindication for mr examination * any person with epilepsy, brain hematomas, brain tumor, or any neurological disease confirmed by ct scan * any other clinical condition which, in the opinion of the principal investigator, would not be suitable for this study

Keywords: acute ischemic stroke stroke mri dti diffusion tensor imaging swi susceptibility weighted imaging outcome axonal injury
carboplatin and paclitaxel in treating patients with locally recurrent or metastatic nasopharyngeal cancer

Conditions: Head and Neck Cancer

Summary: rationale: drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. purpose: phase ii trial to study the effectiveness of carboplatin and paclitaxel in treating patients with locally recurrent or metastatic nasopharyngeal cancer.

objectives: i. estimate the response and toxicity of carboplatin in combination with paclitaxel in patients with locally recurrent or metastatic nasopharyngeal carcinoma. outline: patients receive paclitaxel iv over 3 hours followed by carboplatin iv over 30 minutes. this cycle is repeated every 3 weeks. patients may receive 6-8 cycles of therapy in the absence of toxicity and disease progression. patients are followed every 3 months for the first 2 years, every 6 months for the next 3 years, and yearly thereafter. projected accrual: 30 eligible patients will be accrued in approximately 18 months.

Eligibility criteria:
disease characteristics: histologically confirmed locally recurrent or metastatic nasopharyngeal carcinoma that is not curable with resection or radiation therapy bidimensionally measurable disease patient characteristics: age: 18 and over performance status: ecog 0-1 life expectancy: not specified hematopoietic: absolute neutrophil count greater than 1500/mm3 platelet count greater than 100,000/mm3 hepatic: bilirubin less than 1.5 mg/dl renal: creatinine less than 3.0 mg/dl other: no active infections serum calcium within institutional normal range no history of hypercalcemia prior malignancy other than nasopharyngeal carcinoma allowed no concurrent malignancy not pregnant or lactating fertile patients must use effective contraception prior concurrent therapy: biologic therapy: prior biologic therapy allowed chemotherapy: no prior chemotherapy for metastatic or recurrent disease prior induction or adjuvant chemotherapy concurrent with radiation therapy allowed no prior treatment with paclitaxel endocrine therapy: not specified radiotherapy: see chemotherapy surgery: not specified

Keywords: stage iv nasopharyngeal cancer recurrent nasopharyngeal cancer
a non-interventional study in patients with moderate to severe rheumatoid arthritis treated with roactemra/actemra (tocilizumab)

Conditions: Rheumatoid Arthritis

Summary: this non-interventional study will evaluate the use and efficacy of roactemra/actemra (tocilizumab) in patients with moderate to severe rheumatoid arthritis. eligible patients initiated on roactemra/actemra treatment according to the local label will be followed for 12 months.


Eligibility criteria:
inclusion criteria: * adult patients, \>/= 18 years of age * moderate to severe rheumatoid arthritis according to the revised (1987) acr criteria * patients in whom the treating physician has made the decision to commence roactemra/actemra treatment (in accordance with the local label); this can include patients who have received roactemra/actemra treatment within 8 week prior to the enrolment visit exclusion criteria: * patients who have received roactemra/actemra more than 8 weeks prior to the enrolment visit * patients who have previously received roactemra/actemra in a clinical trial or for compassionate use * treatment with any investigational agent within 4 weeks (or 5 half-lives of the investigational agent, whichever is longer) before starting treatment with roactemra/actemra * history of autoimmune disease or any joint inflammatory disease other than rheumatoid arthritis
the use of indocyanine green near-infrared fluorescence for bowel perfusion quantitative assessment in order to prevent anastomotic leakage in colorectal surgery

Conditions: Colo-rectal Cancer; Colonic Neoplasms Malignant

Summary: anastomotic leakage (al) is a serious complication after surgery for colon cancer, leading to a significant increase in mortality.intraoperative fluorescence imaging using indocyanine green has proven to be a feasible and reproducible technique for real-time perfusion assessment. an increasing number of studies are being published on the use of indocyanine green (icg) fluorescence imaging in colorectal cancer surgery, showing promising results. therefore, we propose conducting a multicenter, randomized controlled trial to investigate the potential use of quantitative assessment of near-infrared fluorescence imaging with indocyanine green (icg) to prevent anastomotic leaks during colorectal surgery.


Eligibility criteria:
inclusion criteria: * patients aged over 18 years old * ecog status 0-2 * written informed consent * histologically confirmed neoplasms malignant of the colon (caecum, ascending, transverse, descending, sigmoid) * scheduled for colorectal resection with primary anastomosis exclusion criteria: * pregnancy or breast feeding * colon obstruction, perforation or bleeding complicating the tumor * medical contraindications for surgical treatment * known allergy or history of adverse reaction to icg, iodine or iodine dyes

Keywords: icg-guided quantitative assessment of bowel perfusion
a clinical study of optimized ct-guided pulmonary nodule microcoil localization technique

Conditions: Pulmonary Nodule, Solitary

Summary: in the early stage of the study, the ct-guided micro-coil locating method for pulmonary small nodules was optimized. this study will use a single set of target values non-randomized controlled trials to evaluate the safety and effectiveness of the optimized pre-loaded micro-coil locating method in pulmonary small nodules.

a series of optimization and improvement measures were tried for the complications of the ct-guided micro-coil locating method. after discussion, the method of micro-coil pre-loaded in the puncture needle and sealed first, and then for subsequent locating has more advantageous. the method avoids the direct penetration of the puncture needle into the atmosphere during operation, and the operation is simpler. in vitro tests of isolated lung specimens and pre-tests of 9 clinical patients were carried out. the results showed that this method not only reduced the number of operators on site, but also had the tendency to shorten the operation time, reduce the incidence of pneumothorax, and improve the success rate. however, there is currently no rigorous scientific research to provide objective evidence for its safety and effectiveness. therefore, this study intends to use a single set of target values non-randomized controlled trials to evaluate the safety and effectiveness of the optimized pre-loaded micro-coil locating method in pulmonary small nodules.

Eligibility criteria:
inclusion criteria: 1. patients between 18 years old (including 18 years old) and 85 years old (including 85 years old); 2. the nodule is clinically suspected to be malignant; 3. those who have no distant metastases; 4. intrapulmonary lesions must meet the following imaging criteria: ① pure ground glass opacity or non-pure ground glass opacity of solid components ≦ 25%; ②solid nodules with diameter ≦ 1 cm or solid components≦ 1 cm non- purely ground glass, and the distance between the solid component of the nodule and the visceral pleural ≧0.5cm; ③ no pleural traction or involving the pleura. exclusion criteria: 1. the lesion site is not suitable for percutaneous lung puncture; 2. those who have pneumothorax and pleural effusion; 3. poor general condition, severe damage to cardiopulmonary function, cachexia, and inability to tolerate surgery; 4. those who refuse surgery; 5. those who did not sign the informed consent form.

Keywords: micro-coil ct-guided locate
an international survey of the occurrence of diseases that affects the heart and blood vessels among people with type 2 diabetes

Conditions: Diabetes Mellitus, Type 2

Summary: the purpose of the study is to register the occurrence of cardiovascular disease among type 2 diabetes (t2dm) patients across five selected countries in europe. participants will be asked to give information about their health. participants will continue their normal way of life and will not get any medication other than what has been prescribed to them by their doctor. participants' participation will be one day/one visit at study doctor. the study will last for about 3 months in total.


Eligibility criteria:
inclusion criteria: * signed informed consent obtained before any study-related activities (study-related activities are any procedures related to recording of data according to protocol) * male or female, age greater than or equal to 18 years at the time of signing informed consent * diagnosed with type 2 diabetes mellitus greater than or equal to 180 days prior to the day of signing the informed consent exclusion criteria: * previous participation in this study. participation is defined as having given informed consent in this study * diagnosed with type 1 diabetes * mental incapacity, unwillingness or language barriers precluding adequate understanding or cooperation * patients with known congenital heart disease/malformation
short term growth in children with atopic dermatitis

Conditions: Atopic Dermatitis

Summary: main objective:to assess short term growth in children with atopic dermatitis during treatment with tacrolimus 0.1% and mometasone furoate 0.1%. a singl blind randomised cross over trial including 20 children. the study consists of 5 periods: run in, treatment(1),wash out, treatment(2) and run out. each period 14 days where the children will use tacrolimus ointment tvice daily, mometasone furoate once daily or moisturizer (in run in wash out and run out)


Eligibility criteria:
inclusion criteria: age 5-14, atopic dermatitis, normal current growth, tanner 1, informed consent by the parent or guardian, willing and able to comply with study procedures exclusion criteria: tanner 2-5, treatment of atopic dermatitis with anti-inflammatory agent within 1 week before the first visit, current asthma or rhinoconjunctivitis that requires treatment with glucocorticoids, endocrine diseases, major surgery within 4 weeks prior to visit 1, fever \>39.5 for \>3 days
effect of early physical exercise on pulmonary ventilation and recruitment

Conditions: Critical Illness

Summary: in the critically patient bed rest and immobilization are some of the responsable of the development of respiratory complications. early physical exercise is a tool to prevent respiratory complications as lost of respiratory muscle strength, decrease in functional residual capacity and hypoxemia improving oxygenation. new technology as electrical impedance tomography (eit) are available to visualize changes of regional lung aeration. the aim of this study is to assess the effect of early physical exercise improving alveolar recruitment and pulmonary ventilation in intensive care unit (icu) patients, evaluated with eit. the icu patients included at day of evaluation will be evaluated continuously with eit in different positions. 1) in the supine position (at 30° of inclination), 2) sitting in chair 3) active physical exercise 4) and rest in chair after exercise


Eligibility criteria:
inclusion criteria: * patient admitted at the intensive care medical/surgical unit of clinic saint luc * days of hospitalization between 1 and 10 * hemodynamically stable * patient or family member sign the informed consent exclusion criteria: * with risk of evisceration * therapy withdrawal * with cardiac devices (pace maker) * persistent cough * patches or open wounds in zone of electrodes * presence of high vasopressor medication (noradrenaline \> 3 mg/h) * peep \> 15 cm h2 * acute myocardial infarction * active bleeding * intracranial pressure \> 20 mm hg or with major instability

Keywords: early physical exercise alveolar recruitment electrical impedance tomography oxygenation ventilation
study to assess effect and safety of high dose of biotin (qizenday®) in progressive multiple sclerosis

Conditions: Progressive Multiple Sclerosis

Summary: the purpose of this observational study is to collect efficacy and safety data in real life condition within the first year of treatment in patients with progressive multiple receiving a daily dose of biotine of 300 mg.


Eligibility criteria:
inclusion criteria: * progressive multiple sclerosis patients with an edss score ≤ 7 who have been prescribed high dose of biotin (temporary use administration) at nantes university hospital (france) exclusion criteria: * patient with remittent recurrent multiple sclerosis * pregnant women or women contemplating pregnancy

Keywords: disability edss
esomeprazole, moxifloxacin and amoxicilin for rescue therapy of helicobacter pylori infection

Conditions: Helicobacter Pylori Infection; Chronic Gastritis

Summary: successful h. pylori eradication therapy remains a challenge in medical practice. despite promising data for first-line, second-line and rescue treatment options based on clinical trials as well as guidelines and expert recommendations, success rates can often not be reproduced in general practice. rescue options for patients with failed initial or second-line therapy are definitely needed. the new fluoroquinolone moxifloxacin may represent an effective and save treatment option (in combination with a ppi and amoxicillin) for rescue therapy of h- pylori positive patients.however, optimal duration of therapy (7-day course vs 14-day course) has to be determined

successful h. pylori eradication therapy remains a challenge in medical practice. currently, a ppi - based triple therapy containing clarithromycin, amoxicillin or nitroimidazole given for 7 days is the recommended first line treatment approach with an expected eradication success rate of approximately 80%. as second-line treatment option in case of failure, a rbc-based quadruple therapy is currently recommended curing another 80% of patients, leaving a subset of patients with persistent h. pylori infection. resistance to fluoroquinolones is low in most countries,hence these compounds are potential candidates for second-line and rescue treatment. the new fluoroquinolone moxifloxacin launched by bayer in 1999 for the treatment of respiratory tract infections, has a broad antibacterial spectrum comparable to levofloxacin but fewer phototoxic and central nervous system excitatory effects. the possible role of moxifloxacin in h. pylori eradication is since under clinical investigation

Eligibility criteria:
inclusion criteria: * male/female, age \>/=18 years * helicobacter pylori infection proven by histology and culture * indication for eradication therapy according to the maastricht-iii * at least one failed prior eradication attempt * pretherapeutic resistance testing (culture) * written informed consent exclusion criteria: * in vitro resistance to moxifloxacin or amoxicillin * current complicated peptic ulcer disease * daily intake of nsaids * co-medication with drugs known to interact with the study medication * history of gastric surgery/vagotomy * medical treatment for depression, known suicide attempt * severe cardiological diseases such as bradyarrythmia, qt changes * malignant disease * gravidity, nursing * women with child bearing potential must perform contraceptive measures

Keywords: helicobacter pylori rescue therapy eradication therapy esomeprazole moxifloxacin resistance
study of budesonide as an addition to standard therapy in adult asthmatics in the emergency room.

Conditions: Asthma

Summary: to determine whether adding nebulized inhaled steroids to the standard care of acutely ill ed patients with refractory acute asthma helps improve forced expiratory volume at one second (fev1) and decrease the need for hospitalization.

this is a randomized clinical trial studying the effect of nebulized budesonide (pulmicort) in acutely ill adults presenting to the emergency department with severe asthma. budesonide is an inhaled steroid fda approved for the treatment of pediatric chronic asthma. ed entry criteria include hyporesponsiveness to nebulized beta-agonists and an fev1\<50% predicted. the trial will evaluate the efficacy of multiple doses of nebulized budesonide as an adjunct to a highly regimented standardized treatment protocol; standard care consists of bronchodilators (beta-agonists/anticholinergics), systemic steroids, and intravenous magnesium sulfate (if the fev1\<25% predicted). the primary efficacy endpoint will be the fev1 4 hours after administration of the study intervention. an additional safety and efficacy endpoint will take place at 5 hours after study intervention. the treatments will be coupled with a protocol-defined assessment regimen, with endpoints measured before each treatment and on ed disposition (at 5 hours after study intervention).

Eligibility criteria:
inclusion criteria: * fev1\<50% predicted after bronchodilator therapy, age 18-60, presenting to an emergency department with acute asthma exclusion criteria: * other chronic lung disease, \>15 pack years smoking

Keywords: acute, emergency department
the impact of emergency physician empathy on litigation propensity

Conditions: Empathy

Summary: the purpose of this study is to observe whether people would report being less likely to sue a physician who shows more empathy when giving a patient potentially bad news regarding their medical condition.

the investigators hypothesized that patients will have less propensity to sue emergency physicians after a poor outcome if the physician demonstrated empathy by verbalizing that they recognize the patient is concerned about their symptoms, and that the patient knows their typical state of health better than a physician seeing them for the first time. accordingly, the investigators will assess whether the presence or absence of emergency physician empathetic statements in videotaped simulated encounters will alter patient propensity towards litigation. secondary objectives are to assess whether the presence or absence of empathetic statements alters patient perceptions of discharge instruction clarity, physician expertness, physician caring, and physician desirability.

Eligibility criteria:
inclusion criteria: * emergency room patient exclusion criteria: * non-english speaking * not healthy enough to be in waiting room

Keywords: empathy communication physician litigation
comparison of reversal of neuromuscular blockade with sugammadex versus neostigmine plus glycopyrolate in patients undergoing burn surgery

Conditions: Burns

Summary: the purpose of this study is to learn if there is a difference in recovery time when using sugammadex versus neostigmine. the researchers also hope to add further knowledge and data to the safety of using sugammadex in burn patients who are hypermetabolic.


Eligibility criteria:
inclusion criteria: * undergoing burn surgery under general anesthesia exclusion criteria: * patients without a non-burned upper extremity * renal insufficiency or failure * sensitivity or hypersensitivity reaction to sugammadex * liver impairment, neuromuscular degenerative disease or dependence on drugs or alcohol

Keywords: muscle function
epidemiology, management and complications related to pancreatic trauma in children

Conditions: Pancreas Injury; Child, Only

Summary: the aim of this study is to better evaluate the treatment and development of children and adolescents who have had a pancreatic trauma and who are being followed in belgian hospitals.

the aim of this study is to better evaluate the treatment and development of children and adolescents who have had a pancreatic trauma and who are being followed in belgian hospitals. through this study, the investigators hope to be able to understand: 1. the epidemiology of pancreatic trauma in belgium. how these traumas occur (accident, fall,...). 2. pancreatic trauma management in belgian hospitals according to severity grade. 3. short- and medium-term complications associated with the trauma 4. long-term complications of trauma on growth and on the endocrine and exocrine function of the pancreas. on the basis of all the information collected, the investigators hope to be able to provide indicators on the epidemiology of pancreatic trauma in children, short-term risks as well as nutritional and functional risks, taking into account the initial management of the patient.

Eligibility criteria:
inclusion criteria: * child aged ˂18 years at the time of the trauma * child regularly followed in paediatric gastroenterology consultation * positive history of pancreatic trauma * child with at least one blood lipase measurement * child with at least one pancreatic imaging available exclusion criteria: * age \>18 years

Keywords: pancreas injury child