Kornimate/medical-research-clean huggingface dataset:
moon shoulder instability-cohort of patients undergoing operative treatment.

Conditions: Other Instability, Shoulder; Dislocations; Subluxations; Recurrent Dislocation of Shoulder Region

Summary: this project will be a multi-center, prospective longitudinal cohort for all patients undergoing primary shoulder instability surgery, excluding isolated slap repairs. we will be looking for risk factors for recurrent instability, revision surgery, and poor outcomes. patients will be asked to complete the rand-36, ases, shoulder activity, eq-5d and wosi outcome measures, as well as demographic and socioeconomic information. surgeons will complete a form after surgery with information on radiographic findings, physical exam, surgical findings, and the repair. patients will wear a sling post-operatively, and follow standardized rehabilitation protocols, including physical therapy. patients will be sent outcome questionnaires at 2, 6, 10, and 20 years after surgery.

the objective of this prospective multicenter cohort study of patients undergoing surgery for glenohumeral instability is to identify the outcomes, and more importantly, the previously unknown predictors of sports function, activity level, general health, recurrent instability symptoms, and surgical failures following surgery. patient information at the time of the surgery (demographics, validated outcome measures), in addition to the physical exam findings, shoulder pathology at the time of surgery, and surgical treatment will be obtained. the validated outcome instruments are american shoulder and elbow surgeons score, western ontario shoulder instability, kerlan jobe overhand athlete score, shoulder activity score, and rand-36. post-operative physical exam data will be obtained at 6 months after surgery. patient reported outcomes will be repeated at 2, 6, 10, and 20 years post-operatively. our multivariable analysis will identify which of the many factors related to the injury, intra-operative treatment, postoperative care, physical patient characteristics, and behavioral patient characteristics contribute to recurrence and poor outcome.

Eligibility criteria:
inclusion criteria: this is a prospective cohort study; there is no control group. subjects that are included are all patients undergoing surgery for shoulder instability. inclusion criteria: * anterior, posterior, and inferior instability * ages 12-99 * open and arthroscopic repair * revision of a previous shoulder instability repair * latarjet/bone augmentation exclusion criteria: * workers compensation patients * prisoners * non-english speaker * not mentally competent * unable/unwilling to return for clinical follow-up * arthroplasty patients * rotator cuff tears * fractures

Keywords: instability
data bank for eosinophilic disorders

Conditions: Eosinophilic Esophagitis; Gastritis; Enteritis; Eosinophilic Colitis; Eosinophilic Gastroenteritis

Summary: the purpose of this study is to conduct a translational study in patients with primary eosinophil associated gastrointestinal disorders \[egid\] (e.g. eosinophilic esophagitis eosinophilic gastritis, eosinophilic enteritis \[ee\], eosinophilic colitis, and eosinophilic gastroenteritis \[ege\]) with the aim of developing a data bank containing pertinent patient demographic information, tissue samples, and dna, which will facilitate research on the pathophysiology of inflammatory disorders and the development of a verified successful clinical treatment program.


Eligibility criteria:
patients with an eosinophil associated gastrointestinal disorder (egid), family members of patients with egid, or normal controls.

Keywords: eosinophilic esophagitis eosinophilic gastritis eosinophilic enteritis eosinophilic colitis eosinophilic gastroenteritis
post-trauma lumbar vertebral body reconstruction using expandable cages

Conditions: Disc Degeneration

Summary: introduction the expandable cage technology is not new, but several questions remain under-studied. among them, there are the sagittal balance, the subsidence and the adjacent disc degeneration. moreover, assessment of the correction and kyphosis regardless of the physiological angles can possibly lead to calculation bias. the objective of this study was to assess the extent to which the functional outcomes were correlated to the quality of the reduction, within a homogeneous series of lumbar vertebral body reconstruction with expandable cages for trauma. material and methods twenty-seven patients with a mean follow-up of 3.9 years were retrospectively analyzed. the oswestry disability index (odi) was the main outcome and its association with other variables was sought. the local kyphosis and the regional traumatic angle using stagnara's physiological angles were measured. the lumbar lordosis (ll) was compared to the pelvic incidence (pi). the subsidence of the cage and the adjacent disc degeneration (using the ucla grading score) were quantified. bone quality was assessed through the hounsfield unit of the vertebral body.


Eligibility criteria:
inclusion criteria: * all patients suffered from a traumatic lumbar fracture requiring a posterior fusion first exclusion criteria: -
a text messaging (sms) intervention to improve adherence to stimulant medication in adults with adhd in the primary care setting

Conditions: Attention Deficit/Hyperactivity Disorder

Summary: this study will assess the efficacy of the text messaging (sms-based) disease management intervention to improve adherence to stimulants in adults with attention deficit/hyperactivity disorder (adhd) within the partners primary and psychiatry care settings. participants in the study will receive customized text messages twice a day, every day, for a duration of 9 months. the text messages will include reminders to adhere to the individualized medication regimen, reminders to call their clinician for a prescription refill followed by reminders to pick up medication from the pharmacy, and educational reminders about adhd and its treatment


Eligibility criteria:
inclusion criteria: * male and female adults ages 18-55 years * receipt of a prescription for stimulant medication by their primary care physician or psychiatrist * proficient in english * has a cellular phone with text messaging capabilities and is interested in and willing to receive free of charge planned text messages exclusion criteria: * investigator and his/her immediate family * unwilling/unable to comply with study procedures

Keywords: attention deficit/hyperactivity disorder adhd sms intervention
desmopressin melt: impact on sleep and daytime functioning

Conditions: Monosymptomatic Nocturnal Enuresis

Summary: nocturnal enuresis affects 10% of the 7-year-old children and is essentially caused by a mismatch between nocturnal bladder capacity and the amount of urine produced during the night together with failure of the child to awaken in response to a full bladder.urine overproduction at night or nocturnal polyuria (np) is a major factor contributing to monosymptomatic nocturnal enuresis (mne) pathophysiology in a large proportion of patients. since np is related to an abnormal circadian rhythm of arginine vasopressin (avp) secretion, the synthetic avp analogue desmopressin is widely used to treat mne. it is recommended by the international consultation on incontinence (grade a,level 1). desmopressin is available in 3 different formulations: nasal spray, tablet and the newest form melt. baeyens et al demonstrated an increased prevalence of attention deficit-hyperactivity disorder (adhd) in children with mne according to recent data there is a high incidence of periodic limb movements in sleep at night in children with nocturnal enuresis. those children have an increased cortical arousability leading to awakening. the frequent awakening most likely has an influence on concentration and other adhd-symptoms in daily life. this study will assess the impact of desmopressin melt on prepulse inhibition, adhd-symptoms, cognition and learning, sleep, quality of life and self esteem. new patients aged 6-16 years with monosymptomatic nocturnal enuresis, nocturnal polyuria and sleep problems are tested before the start of the study medication desmopressin melt (t1) and 6 months later (t2). it is a multi-method, multi-informant study.


Eligibility criteria:
inclusion criteria: * new patient * age 6 to 16 years * monosymptomatic nocturnal enuresis, nocturnal polyuria and sleep problems exclusion criteria: * mental retardation * autism spectrum disorders * daytime incontinence resistant to therapy * dysfunctional voiding * poor therapy-compliance * diuretics, antihypertensives, uropathy, renal abnormalities

Keywords: enuresis
physical activity counseling after bariatric surgery

Conditions: Obese; Quality of Life; Exercise; Behavior, Health; Bariatric Surgery

Summary: this study will examine whether providing physical activity counseling and guidance to patients post bariatric surgery, along with long-term personal follow-up for six months after the surgery, may increase the level of physical activity, and it's effect on anthropometric and functional measures.

bariatric surgery is considered to be most effective in treating morbid obesity for patients with bmi≥40 or bmi≥35 with comorbidity for obesity. postoperative weight loss following any type of bariatric surgery is largely dependent on the extent to which patients can make and sustain changes in their eating habits and activity level. adopting physical activity habits can help to optimize outcomes after bariatric surgery, such as contributing to the rate of weight loss after the surgery and maintain lean body mass. in order to successfully implement a behavioral change regarding the adaptation of healthy lifestyle habits in obese patients, it is vital to promote physical activity counseling after the surgery, and to find an effective intervention that can support habitual physical activity. the aim of this trial is to examine the effect physical activity counseling after bariatric surgery on the amount and intensity of activity performed, quality of life, anthropometric and functional measures during the first year after surgery. up to eighty participants will be recruited for the trial, and will be randomly assigned to one of the two study arms (control, intervention). the intervention group will receive physical activity counseling and guidelines for the following six months after the surgery. all participants will receive a pedometer to track daily steps for 7 days at different time points before and after the intervention. additional measurements will be taken at a pre-surgical baseline assessment and throughout the trial, and will include anthropometric measures (weight, bmi, and body composition) and functional measures (handgrip, 6-minute walk test, chair stand-up test). all participants will fill out a the 7-day international physical activity questionnaire, self-efficacy for physical exercise scale, and sf-36 questionnaire, before and after the intervention.

Eligibility criteria:
inclusion criteria: * bmi ≥ 40 kg/m2 or 35 kg/m2 with comorbidities * 18 to 50 years old * patient is suitable according to the pre-operative evaluation standards to undergo bariatric surgery * speaks hebrew/arabic fluently exclusion criteria: * cognitive decline or severe psychiatric or mental illness * patient undergone bariatric surgery in the past * pregnancy or breastfeeding * orthopedic disease that limits training and mobility (such as severe arthritis, injury or fractures) * heart disease with a risk to exercise (heart failure, severe aortic stenosis, uncontrolled arrhythmia, and acute coronary syndrome) * moderate /severe lung disease or copd with fev1 / fvc \<70% on a pulmonary function test

Keywords: physical activity exercise
supplemental study to evaluate the safety and effectiveness of the novacross™ micro-catheter

Conditions: Coronary Occlusion

Summary: this study will include up to 60 eligible male and female subjects. the purpose of this trial is to evaluate the safety and effectiveness of the novacross™ micro-catheter when used to facilitate crossing of chronic total occlusion (cto) lesions in coronary arteries. the procedure will be conducted on consenting patients diagnosed with a cto in a coronary vessel that requires revascularization after a previously failed attempt to cross or refractory to 10 minutes of conventional guidewire attempt. this study is an extension study of nitiloop's pivotal study.

the purpose of this trial is to evaluate the safety and effectiveness of the novacross™ micro-catheter when used to facilitate crossing of chronic total occlusion (cto) lesions in coronary arteries. the procedure will be conducted on consenting patients diagnosed with a cto in a coronary vessel that requires revascularization after a previously failed attempt to cross or refractory to 10 minutes of conventional guidewire attempt.

Eligibility criteria:
inclusion criteria: 1. adult aged 25-80 2. patient understands and has signed the study informed consent form 3. patient has an angiographic documented chronic total occlusion (i.e. \>3 months occlusion duration) showing distal timi flow 0, with a reference diameter of at least 2 millimeters. 4. left ventricle ejection fraction \> 25% exclusion criteria: 1. patient unable to give informed consent. 2. elevated ck-mb or troponin at baseline 3. patient is known or suspected not to tolerate the contrast agent 4. chronic total occlusion is located in aorto-ostial location, svg cto, in-stent occlusion 5. appearance of a fresh thrombus or intraluminal filling defects 6. intolerance to aspirin and/or inability to tolerate a second antiplatelet agent (clopidogrel and prasugrel and ticagrelor) 7. cardiac intervention within 4 weeks of the procedure 8. severe renal insufficiency with egfr\ 180/100 mmhg) v. unstable angina requiring emergent percutaneous trans-luminal coronary angioplasty (ptca) or coronary artery bypass graft (cabg)
a retrospective study to evaluate the early real-world evidence of brolucizumab in patients with neovascular age-related macular degeneration (namd) in india

Conditions: Neurovascular Age-related Macular Degeneration

Summary: this non-interventional, retrospective, observational, noncomparative, non-randomized, single-arm, multi-centre study included patients (≥50 years) diagnosed with neovascular age-related macular degeneration (namd) in at least 1 eye. anonymized data of patients treated with brolucizumab intravitreal injection (ivi) who had received the first dose of brolucizumab between 01 october 2020 and 31 march 2021 was collected. patients could either be treatment-naïve or previously treated with single or a combination of other ivi of anti-vascular endothelial growth factors (vegfs). the primary outcome measure was the change in fluid levels (intra-retinal fluid \[irf\], sub-retinal fluid \[srf\], and pigment epithelial detachment \[ped\]) from baseline to month 3. secondary outcome measures included change in best-corrected visual acuity (bcva) and central retinal thickness (crt), number of brolucizumab injections, and safety (number of adverse events \[aes\]). descriptive statistics were tabulated for the demographic and clinical characteristics as well as outcome variables.


Eligibility criteria:
inclusion criteria: * treatment-naïve namd patients or patients previously treated with a single or a combination of other intravitreal anti-vegfs * patients (male or female) ≥50 years of age at the index date * patients with visual acuity (va) and optical coherence tomography (oct) assessments at baseline and at least 1 month after initiating treatment with brolucizumab * patients treated with ivi of brolucizumab (received the first dose of anti-vegf injection during the index period \[01 october 2020 to 31 march 2021\]) exclusion criteria: * patients with dry amd, geographic atrophy, and other retinal diseases in the study eye * patients who were part of any other namd trial/study during the study period * patients undergoing additional ocular treatment along with other anti-vegf agents
mucosal impedance and eosinophilic esophagitis

Conditions: Eosinophilic Esophagitis

Summary: do patients with eosinophilic esophagitis have baseline increased esophageal mucosal impedance? and will treatment that reverses esophageal eosinophilia in patients, correct abnormalities in mucosal impedance?


Eligibility criteria:
inclusion criteria: * adults ages 18-90 undergoing clinically indicated upper endoscopy * patients with eoe, defined as dysphagia with histologic finding of greater than or equal to 15 eosinophils per high powered field on esophageal biopsy despite at least 6 weeks of twice daily proton pump inhibitor therapy * patients undergoing clinically indicated upper endoscopy for indications other than dysphagia or gastroesophageal reflux disease (gerd) with normal appearing esophageal mucosa. exclusion criteria: * medical conditions such as severe heart or lung disease that preclude safe performance of endoscopy * patients with conditions known to be associated with esophageal eosinophilia, including crohn's disease, churg-strauss, achalasia, and hypereosinophilic syndrome * inability to read due to: blindness, cognitive dysfunction, or english language illiteracy

Keywords: mucosal impedance eosinophilic esophagitis eoe
ozurdex® in patients with non-infectious uveitis affecting the posterior segment of the eye

Conditions: Non-infectious Uveitis

Summary: this observational study will evaluate the safety, efficacy, characteristics of patients, characteristics of physicians and quality of life in patients who are prescribed ozurdex® as treatment for non-infectious uveitis of the posterior segment of the eye in france.


Eligibility criteria:
inclusion criteria: -patient with non-infectious uveitis affecting the posterior segment of the eye. exclusion criteria: -patient not residing in metropolitan france.
hand massage after acute coronary syndrome

Conditions: Acute Coronary Syndrome; Anxiety

Summary: patients suffering from acute coronary syndrome may be hospitalized again in a shorter time than expected, and after being discharged, they may live within the limitations imposed by the disease until the end of their lives. this situation causes anxiety in individuals. today, various methods are used to reduce high levels of anxiety. massage is the planned and purposeful application of touch and is the most common, most important and oldest complementary treatment used in traditional practices. it is also thought that the comfort levels of individuals experiencing acs will increase by reducing their anxiety. this study was planned to determine the effect of hand massage applied to patients with acs on comfort, anxiety level and vital signs.


Eligibility criteria:
inclusion criteria: * patients experiencing acute coronary syndrome for the first time, * anxiety score of 16 and above (moderate and severe anxiety) * 18 years and above, * no psychiatric disease, * patients who do not have communication problems and are competent to answer all questions, exclusion criteria: * patients with uncontrolled diabetes mellitus * patients who cannot communicate and have confusion, * those who have any limb, vascular problem or wound that prevents hand massage, * thrombophlebitis, occlusive arterial disease, fever etc. those for whom massage therapy is inconvenient due to illness,

Keywords: acute coronary syndrome anxiety comfort han massage
muscle energy technique versus mulligan technique for treating neck pain in breast feeding women

Conditions: Neck Pain; Breast Feeding

Summary: the purpose of this study will determine the effect of muscle energy technique versus mulligan technique on neck pain in breastfeeding women.

conservative treatments used to manage neck pain are numerous and include usual medical care ( face to face interview, education, reassurance, medication, ergonomic and stay active advice), various forms of exercise, massage, and acupuncture among others, but a lack of evidence regarding their relative efficacy was found. more research is needed to determine specific exercise programs that can decrease neck pain in breastfeeding women. so, this study will be conducted to determine clinical evidence of the effectiveness of muscle energy technique versus mulligan technique on neck pain, which constituted a great problem facing the mother during the breastfeeding period.

Eligibility criteria:
inclusion criteria: * patients will be examined by a physician before the study and will be chosen according to the following criteria: * all patients will be in the breastfeeding period at least 6 weeks after delivery. * all patients will be clinically diagnosed with neck pain (with no neurological or rheumatological problem). * their ages will range from 25-35years. * their bmi will be less than 30 kg/m². * their parity will not be more than 3 times. exclusion criteria: * the patients will be excluded if they have any of the followings: 1. any contraindication to spinal mobilization (e.g., inflammation, infection, advanced degeneration, congenital malformation, trauma, cerebrovascular abnormalities). 2. positive neurological examination (presence of positive motor reflex, or sensory abnormalities indicating spinal root compression). 3. cervical spine surgery or stenosis, metabolic or systemic disorder, or cancer. 4. associated pathology of the upper cervical region or upper limb that may cause overlapping with the clinical finding as referred pain from the costotransverse joint, rotator cuff tendonitis, and cervical rib syndrome.
an investigational scan (ga-68 psma-11 pet/ct) for the detection of therapy response in patients with metastatic adenoid cystic carcinoma

Conditions: Metastatic Adenoid Cystic Carcinoma

Summary: this phase ii trial tests whether gallium-68 (ga-68) prostate specific membrane antigen (psma)-11 positron emission tomography (pet)/computed tomography (ct) imaging is useful for detecting therapy response in patients with adenoid cystic carcinoma (salivary gland cancer) that has spread from where it first started (primary site) to other places in the body (metastatic). the pet scan detects and takes pictures of where the radioactive imaging agent (68ga psma-11) has gone in the body and the ct scan uses x-rays to create images of the bones and internal organs within the body. combining a pet scan with a ct scan can help make the images easier to interpret. this study may help researchers learn whether ga-68 psma-11 pet/ct is useful for detecting treatment response and guiding treatment decisions in patients with metastatic adenoid cystic carcinoma.

primary objectives: i. evaluate the feasibility of serial ga-68 psma pet/ct for response assessment in metastatic adenoid cystic carcinoma. ii. assess the correlation of psma pet/ct response assessment with serum extracellular vesical (ev) psma levels for patients undergoing treatment for metastatic adenoid cystic carcinoma. outline: patients receive ga-68 psma-11 intravenously (iv) and then undergo pet/ct 50-70 minutes after injection at baseline and approximately 12-20 weeks during investigational therapy. after completion of study intervention, patients are followed up at 1 day.

Eligibility criteria:
inclusion criteria: * ≥ 18 years of age * diagnosis of metastatic adenoid cystic carcinoma * enrolled in protocol mc200708 * ability to tolerate a ga68 psma pet/ct imaging study * willingness to return for a second psma pet/ct scan in approximately 12-20 weeks from the baseline pet/ct * ability to give appropriate consent or have an appropriate representative available to do so exclusion criteria: * unable to undergo pet/ct scan * not a participant in mc200708 * \< 18 years of age * persons who are pregnant or nursing * persons unable to consent to the study