Kornimate/medical-research-clean huggingface dataset:
innate immune response of blood cells in patients with pneumonia

Conditions: Lobar Pneumonia

Summary: pulmonary bacterial infections such as exacerbations of chronic bronchitis, nosocomial and community-acquired pneumonia represent a major public health issue. antibiotics have shown their efficacy by direct antimicrobial activity and their limit particularly in case of multidrug-resistant microorganisms or in treating patients with aggravating pathologies. innate immunity could be an alternative or complementary therapeutic pathway. innate immunity receptors bind universal and invariant microbial molecular patterns present in bacteria, virus, fungus or parasite. toll-like receptors (tlr) activation by microbial agonist stimulates the innate immunity response which results in the production of chemokines, cytokines, antimicrobial molecules and the recruitment of innate cells. the " pulmonary infection and innate immunity " team of the immunity and infection center in lille (group of dr. sirard and carnoy) has a long expertise in the study of tlr5 and its agonist, the flagellin, a structural protein of bacterial flagella. tlr5 is expressed on the cell surface of macrophages, monocytes, dendritic and epithelial cells. several studies in mice have shown the flagellin prophylactic potential during bacterial infections through a tlr5 dependent stimulation of innate immunity. recently, the group of dr. sirard and carnoy has shown that flagellin can be used in association with antibiotics to treat streptococcus pneumoniae respiratory infections in mice. the results demonstrate that an agonist of tlr can increase the therapeutic index of an antibiotic and improve the pulmonary anti-infectious reaction. this innovative approach allows us to consider new antibacterial strategies where antibiotics have reached their limit (nosocomial infection, multidrug-resistant bacteria...). tlr agonists can activate multiple human cell type. indeed, blood cells activation by tlr agonists have been recently characterized in healthy volunteers. however, there is no available data on the ability of tlr agonists to activate cells from patients with infectious pneumopathies. a study in these patients is inevitable if one is to consider the therapeutic use of agonists in respiratory pathologies.


Eligibility criteria:
inclusion criteria: * adult patient hospitalized in the department of pneumology for whom clinical, radiological and biological criteria confirm the diagnosis of lobar pneumonia * beneficiary of the french national health insurance fund * signed informed consent form exclusion criteria: * patient under guardianship * patient with acute respiratory distress syndrome or septic shock * pregnant women * patient with hiv, hcv or mycobacterium tuberculosis * transplanted patient receiving immunosuppressive therapy
does hydroxyzine decrease anxiety in underweight patients diagnosed with an eating disorder

Conditions: Anxiety in Those Patients With Anorexia Nervosa; Eating Disorder Not Otherwise Specified, BMI (<=18)

Summary: the purpose of this study is to determine the effectiveness of hydroxyzine in the treatment of meal-related anxiety in adolescents and young adults 8 to 25 years of age diagnosed with an eating disorder who are underweight. the investigators want to find out if hydroxyzine given before meals will improve meal-related anxiety compared to no hydroxyzine.

this study is a practiced-based pilot study in follow-up to clinical observations made by our treatment team that hydroxyzine attenuates meal-related anxiety and improves treatment adherence in patients with a diagnosis of anorexia nervosa (an) (excluding the amenorrhea criterion) or eating disorder not otherwise specified (ednos) specifically with low bmi (≤ 18). to our knowledge, hydroxyzine has never been formally investigated in treating meal-related anxiety and improving outcomes in patients with an or ednos specifically with low bmi (≤ 18).

Eligibility criteria:
inclusion criteria: * admitted to the intensive structured living unit (isl) at melrose institute for treatment of an eating disorder that meets dsm-iv criteria for anorexia nervosa (excluding the amenorrhea criterion), or eating disorder not otherwise specified, specifically with bmi (≤ 18) * age 8-25 years old at admission to isl. * weight ≥ 15 kg at admission to isl. * stable psychotropic and/or sedative medications for at least (≥) 6 weeks exclusion criteria: * age \< 8 years * age ≥ 25 years * weight \< 15 kg at admission to isl * prolonged qt interval on ecg at admission to isl * current substance or alcohol abuse or dependence * malabsorption syndrome or inability to take oral medications * history of hydroxyzine intolerance or hypersensitivity * history of type 1 diabetes mellitus * history of angle closure glaucoma * currently on another clinical trial * pregnancy

Keywords: treating meal related anxiety
dry eye evaluation system based on bioinformatics

Conditions: Dry Eye

Summary: dry eye is a common ocular surface disease of multifactorial etiology characterized by elevated tear osmolality and inflammation leading to a disrupted ocular surface. the latter is a risk factor for ocular surface infection, yet overt infection is not commonly seen clinically in the typical dry eye patient. this suggests that important innate mechanisms operate to protect the dry eye from invading pathogens. understand the pathogenesis of dry eye will be the measure to prevention and treatment of dry eye. in this essay, the investigators use the data of experiment in the patients with dry eye and normal, acquire their tear production, tear film stability, and surface damage. the investigators use weka to calculate the prediction accuracy of the 6 algorithm and select the best one, optimize the parameters to get the final prediction accuracy.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of dye eye exclusion criteria: * systemic disease (such as diabetes, glaucoma, or systemic collagen vascular disease), ocular disease, a history of tear supplement usage or contact lens wear during the past year,and pregnancy

Keywords: dry eye bioinformatics data mining
web-based smoking intervention as an add-on to routine smoking cessation clinical treatment

Conditions: Smoking Cessation

Summary: this study evaluated the effectiveness of an online psycho-education program offered in addition to routine care for individuals attending a smoking cessation clinic. conducted as a randomized controlled trial, the study assigned 103 participants to the intervention group and 105 to the control group. based on follow-up data, analyses were carried out with 37 participants from the intervention group and 24 from the control group. primary hypotheses among individuals who applied to the smoking cessation outpatient clinic at the institute on drug abuse, toxicology, and pharmaceutical science, ege university, those who receive additional online psychoeducational support integrated into the outpatient service are expected to: h1: be more successful in quitting smoking compared to those who do not receive this support. h2: be more successful in reducing the number of cigarettes smoked per day. h3: show a significant change in their level of nicotine dependence. secondary hypotheses h4: show significant progress in the stages of change regarding smoking behavior. h5: show significant improvement in their mental well-being.

abstract determination of effectiveness of online psycho-education embedded in routine service delivery for smoking cessation: a randomized controlled trial objective: this study aims to evaluate the effectiveness of online psychoeducation provided in addition to routine treatment in a smoking cessation clinic compared to routine treatment alone. method: the study is a single-center, single-blind, randomized controlled experimental trial conducted between may 2024 and january 2025 at the smoking cessation clinic of the ege university institute on substance abuse, toxicology, and pharmaceutical sciences. participants were randomly assigned to the intervention (n=103) and control (n=105) groups in a 1:1 ratio. during the study, the warwick-edinburgh mental well-being scale short form (wemwbs-sf), the fagerström nicotine dependence test (fnbt), and a case information form including hapa stages of change were administered. the primary outcomes of this study are cigarette consumption, fnbt score, and smoking cessation success. the secondary outcomes include the hapa stage of change and mental well-being score. confounding variables considered in the study include education level, age, gender, employment status, mental health issues, marital status, and smoking cessation attempt. based on follow-up data, analyses were conducted using data from 37 participants in the intervention group and 24 in the control group. data analysis included paired and independent samples t-tests, chi-square analysis, one-way anova, and linear and logistic regression analysis.

Eligibility criteria:
inclusion criteria: * using internet * being a volunteer exclusion criteria: * not using internet * not being a volunteer

Keywords: tobacco use disorder smoking cessation web-based psycho-education
preferences & treatment satisfaction drivers in rosacea patients

Conditions: Rosacea

Summary: to survey patients with rosacea about their rosacea treatment preferences as well as to assess potential drivers of rosacea treatment satisfaction.


Eligibility criteria:
inclusion criteria: * male or female patients of at least 18 years of age at index date * at least one prescription for a topical rosacea treatments: azelaic acid gel, azelaic acid cream, metronidazole gel, metronidazole cream, metronidazole emulsion, metronidazole lotion, brimonidine tartrate gel * at least one medical record with a diagnosis code for rosacea (icd-9: 695.3) * at least 6 months of data history prior to the index date * had at least one encounter at the reliant medical group within 3 months prior to 01 january 2015 exclusion criteria: * none
clinical evaluation of aromatic wentong in the treatment of coronary microvascular disease

Conditions: Coronary Microvascular Disease

Summary: coronary microvascular disease (cmd) is a condition where patients experience chest pain (angina) even though their coronary arteries appear normal on angiography. it is common among people with coronary heart disease, especially those with chest pain as their main symptom. unfortunately, there are no effective treatments available for these patients, and symptoms like chest tightness and persistent pain greatly affect their quality of life. traditional chinese medicine (tcm) suggests that the root cause of microvascular disease is blocked collateral blood vessels. aromatic wentong, a tcm approach, aims to improve blood flow and relieve blockages. kuangxiong aerosol is a chinese patent medicine developed based on the principles of aromatic wentong. this study is a multicenter, randomized, double-blind, placebo-controlled trial involving 528 patients with chest pain and suspected cmd. participants are recruited from several hospitals, including china-japan friendship hospital, fuwai hospital, and xiyuan hospital. patients are randomly divided into two groups: the intervention group receives standard guideline-recommended treatment plus kuangxiong aerosol. the control group receives standard treatment plus a placebo version of kuangxiong aerosol. the treatment lasts for 8 weeks.


Eligibility criteria:
inclusion criteria: * aged between 18 and 80 years, regardless of gender. * clinical symptoms of myocardial ischemia. * objective evidence of myocardial ischemia, including: 1. ecg changes during chest pain episodes, 2. stress test-induced chest pain symptoms and/or abnormal myocardial blood flow and/or abnormal cardiac wall motion with ischemic ecg changes. * coronary angiography (cag) showing \>50% reduction in the diameter of the epicardial coronary artery. * qfr \> 0.80 and amr \> 2.5 mmhg·s/cm. * discontinuation of all chinese medicine interventions for at least two weeks prior to enrollment. * provision of informed consent and a signed informed consent form. exclusion criteria: * significant liver or kidney dysfunction, defined as alt, ast, or blood creatinine levels \>3 times the upper limit of normal. * severe cardiac conditions, including heart failure, myocarditis, cardiomyopathy, acute pericarditis, structural heart disease. * severe systemic diseases, such as severe mental illness, hematopoietic system disorders, or malignant tumors. * suspected or confirmed allergy to the trial drug. * individuals deemed by researchers to be unsuitable for participation in the clinical trial. * women who are pregnant, planning to become pregnant, or currently lactating.
paclitaxel with / without gw572016 (lapatinib) as first line therapy for women with advanced or metastatic breast cancer

Conditions: Neoplasms, Breast

Summary: the purpose of this study is to determine the efficacy and safety of an oral dual tyrosine kinase inhibitor (gw572016) in combination with paclitaxel compared to paclitaxel alone in first line advanced or metastatic breast cancer.


Eligibility criteria:
inclusion criteria: * signed informed consent * able to swallow an oral medication * cardiac ejection fraction within the institutional range of normal as measured by echocardiogram * adequate kidney and liver function * adequate bone marrow function * tumor tissue available for testing * prior adjuvant or neoadjuvant therapy is permitted with an anthracycline or anthracenedione-containing regimen however, subjects must have had cumulative doses of less than 360 mg/m2 of doxorubicin, 720 mg/m2 of epirubicin, or 72 mg/m2 of mitoxantrone * no her2/neu overexpression in tumor tissue tested or status unknown if tissue has never been tested exclusion criteria: * prior treatment regimens for advanced or metastatic breast cancer. * pregnant or lactating * conditions that would effect the absorption of an oral drug * active infection * brain metastases * treatment with egfr (endothelial growth factor receptor) inhibitor. * known hypersensitivity to taxol or excipients of taxol * peripheral neuropathy of grade 2 or greater is not permitted * severe cardiovascular disease or cardiac disease requiring a device. * serious medical or psychiatric disorder that would interfere with the patient's safety or informed consent.

Keywords: metastatic breast cancer erbb1 kinase inhibitor erbb2 egfr lapatinib her2-neu
is three d power doppler of the endometrial and subendometrial regions effective in predicting endometrial implantation?

Conditions: Infertility

Summary: three d power doppler us was done for every woman at the day after hcg administration. ovum pick up was done after 35 hours following hcg administration. the luteal phase was supported by progesterone 300 mg per day (progest, micronized progesterone 100mg, technopharma, egypt, for pharco pharmaceuticals, amriya- alexandria). five days following ovum pick up, the embryos were transferred at the blastocyst stage.

all women underwent long agonist protocol for controlled ovarian hyperstimulation described by chang et al. (14) the gnrh agonist was started in the previous mid-luteal phase (decapeptylr r 0.1mg, triptorelin-acetate, ferring gmbh, wittland 11, d-24109, and kiel, germany). after the confirmation of pituitary down regulation (serum lh less than 5 m iu/ml and serum e2 less than 50 pg /ml), the hmg ampoules were started by 225 iu/day (gonapure 75 iu, ibsa institute biochimique sa, switzerland). during the follow up of overstimulation, the doses were adjusted according to the response of patient. all women underwent serial tvs until at least three dominant follicles were reached in every woman. when the dominant follicles reached 18-20 mm, hcg 10000 (choriomon 5000 iu, ibsa institute biochimique sa, switzerland) was administered. three d power doppler us was done for every woman at the day after hcg administration. ovum pick up was done after 35 hours following hcg administration. the luteal phase was supported by progesterone 300 mg per day (progest, micronized progesterone 100mg, technopharma, egypt, for pharco pharmaceuticals, amriya- alexandria). five days following ovum pick up, the embryos were transferred at the blastocyst stage. twelve days later to embryo transfer, serum pregnancy test was done and if positive (chemical pregnancy), the clinical pregnancy was confirmed by tvs for detection of gestational sacs and embryo cardiac activity. the ongoing pregnancy was detected by abdominal ultrasound at 12 weeks.

Eligibility criteria:
inclusion criteria: a * age; 22-35 years, * bmi; less than 35 kg/m2, * husband with oligo- or oligoasthenospermia. exclusion criteria: * \\1-gross uterine and tubal pathology, * 2-development of ohss, * 3-poor responders, * 4-failure of oocyte fertilization or failure of the embryos to reach the blastocyst stage and * 5-refusal to participate in the study at any step of the icsi cycle.

Keywords: doppler,endometrial,implantation
protexa® versus tiloopbra® in immediate breast reconstruction- a pilot study

Conditions: Breast Cancer; Hereditary Breast and Ovarian Cancer Syndrome

Summary: randomized controlled trial to look at early complications, cosmetic outcome, patient satisfaction and thickness of the tissue overlying the implant at the lower pole in immediate implant based breast reconstruction after skin or nipple sparing mastectomy with either a mesh (tiloop bra) or an adm (protexa). multicenter austrian trial with four breast cancer centers, 50 patients randomized 1:1 in the tiloop or protexa group.


Eligibility criteria:
inclusion criteria: * breast cancer patients with indication for skin or nipple sparing mastectomy * brca1/2 mutation carriers with indication for skin or nipple sparing mastectomy exclusion criteria: * prior local radiotherapy * inflammatory breast cancer

Keywords: breast reconstruction mesh acellular dermal matrix
anorexia and personality traits in elderly individuals

Conditions: Anorexia; Personality; Aging; Chronic Disease

Summary: the aim of this study is to evaluate the relationship between age-related anorexia and personality traits in elderly individuals with comorbidities.

there is no study in the literature investigating the relationship between personality traits and age-related anorexia. the aim of this study is to evaluate the relationship between age-related anorexia and personality traits in elderly individuals with comorbidities.

Eligibility criteria:
inclusion criteria: * being 65 years or older, * volunteering to participate in the study, * being conscious and not having communication problems, * having a charlson comorbidity index of 1 or higher and/or a diagnosis of hypertension, * being fed orally. exclusion criteria: * oropharyngeal dysphagia, * presence of neurological or muscular disease that prevents swallowing, * being fed by nasogastric tube, percutaneous endoscopic gastrostomy or intravenous nutrition, * using drugs that affect appetite (corticosteroid, cancer chemotherapy digoxin, opioids, serotonin reuptake inhibitors, topiramate), * using appetizers (megestrol acetate, dronabinol, mirtazapine, growth hormone analogue), * having an active cancer disease, * major neuro-psychiatric disease (alzheimer's, dementia, major depression, mania, psychosis, etc.), * presence of acute infection, * not having sufficient communication skills (mini mental test score below 24 points).

Keywords: anorexia personality aging chronic disease
continuous versus interrupted sutures for repair of episiotomy or second degree tears: a randomised controlled trial

Conditions: Pain

Summary: the best technique for this repair would be that which requires least time in realisation, least consumption of material for the repair and that which produces less pain at short and long-term permitting the resumption of intercourse quicker and with less pain thereby requiring less necessity to take out the stitches and less frequency of re stitching. the investigators research is looking for a technique for repairing the perineum more advantageously.

445 women who participated in the project had undergone normal deliveries with episiotomy or second-grade tearing of the perineum. one group was repaired with continuous non-locking suture in the vagina, perineum and subcutaneous tissue. the other group used continuous locking suture of the vagina, interrupted sutures in the perineum muscle and interrupted transcutaneous suture. the threads used for stitching were identical in both groups. the same questions were asked concerning the sensation of pain and the use of painkillers, the second and the tenth day and at the three months.

Eligibility criteria:
inclusion criteria: * vaginal childbirth * at least 37 weeks of gestation * assistance by one of the 4 matrons who participated in the project * have been subjected to an episiotomy or the appearance of tearing that affected skin and muscle * the newborn child had to be alive, viable exclusion criteria: * instrumentation * produce injury in the anal sphincter or in the rectum. * serious congenital malformations.

Keywords: episiotomy perineal lesion vaginal trauma
effectiveness of screening and counselling for elderly with psychological problems

Conditions: Mental Illness

Summary: the aim of the study is to test whether screening followed by brief problem-solving counselling in primary care could improve the quality of life of elderly patients with undiagnosed psychological problems. we hypothesize that undiagnosed psychological problems detectable by screening are common in the elderly and brief counselling could improve the quality of life of these patients.

objectives: the aim of the study is to test if screening followed by brief problem-solving counselling by primary care doctors can improve the health-related quality of life (hrqol) of elderly patients with previously undiagnosed psychological problems. it will also find out the effects of undiagnosed psychological problems on hrqol and consultation rates of elderly patients. design, setting \& subjects: this is a prospective single-blinded randomised controlled trial on 450 patients aged 60 or above attending a government general outpatient clinic in hong kong, who have been screened for psychological problems. methods: elderly patients attending the general outpatient department of the ap lei chau clinic who are not known to have the diagnosis of psychological problems with the hospital anxiety \& depression scale (hads) were screened in order to recruit 300 subjects who are screened positive for undiagnosed psychological problems will be randomised into the counselling or no-counselling groups, and 150 subjects who are screened negative for psychological problems will be selected as normal controls interventions: the counselling group will receive brief problem-solving counselling from a trained primary care doctor in addition to their usual medical care; the no-counselling group will receive general health education and their usual medical care; and the normal control group will continue with their usual care only. main outcome measures: health-related quality of life measured by the sf-36, the hads scores and consultation rates. the baseline and changes in outcomes of the three groups will be compared at 0, 6, 12, 36 and 52 weeks after screening. conclusions: the results will provide evidence on whether screening followed by brief problem-solving counselling in primary care is effective in improving quality of life and reducing consultation rates for the elderly with undiagnosed psychological problems.

Eligibility criteria:
inclusion criteria: 1. aged 60 or above 2. attending the study primary care clinic 3. no known diagnosis of psychological problem 4. written consent provided exclusion criteria: 1. known psychological disease diagnosed by a registered practitioner 2. taking any psychotropic drug prescribed by a registered practitioner of western medicine within the last year; 3. has suicidal plan or strong suicidal thought; 4. has psychotic symptom; 5. any impairment in cognitive function; or 6. any communication problem 7. refuses to participate

Keywords: mental health screening elderly chinese problem-solving counselling