Kornimate/medical-research-clean huggingface dataset:
knee osteoarthritis and kinesiophobia

Conditions: Knee Osteoarthritis; Kinesiophobia

Summary: kinesiophobia after total knee arthroplasty is an important parameter affecting recovery. however, the relationship between kinesiophobia and the factors it may cause is not clear. therefore, this study aimed to examine the relationship between kinesiophobia, pain, fear of falling, mobility and proprioception in the early period after total knee arthroplasty.

various biopsychosocial factors affect the recovery process and quality of life after total knee arthroplasty. this situation reaches a level that can affect the daily life activities of patients, especially in the long term. especially kinesiophobia is one of these factors. this condition also affects the proprioceptive sense in the knee, the capacity to move and the fear of falling. however, studies have generally examined long-term effects after total knee arthroplasty. early studies are limited in number. more studies are needed to better understand the relationship between kinesiophobia and biopsychosocial factors. additionally, the lack of relationship between the patients' kinesiophobia level, fear of falling, and proprioception in the early period after tka draws attention. therefore, this study aimed to examine the relationship between kinesiophobia, pain, fear of falling, mobility and proprioception in the early period after tka.

Eligibility criteria:
inclusion criteria: * being between the ages of 18-80 * total knee arthroplasty surgery due to knee osteoarthritis * volunteering to participate in the study exclusion criteria: * previously had knee surgery or fracture * diagnosed with rheumatoid arthritis * those with severe obesity (bmi \> 40 kg/m2) * those with sensory and motor impairments * revision knee arthroplasty planned * venous thromboembolism * neurological diseases (ms, parkinson, etc.) * early post-surgical complications
the use of steri3x for prevention of post-operative wound infections in cesarean sections

Conditions: Surgical Site Infection; Cesarean Section; Complications, Wound, Infection (Following Delivery); Postpartum Complication

Summary: postpartum infection if a major cause of maternal morbidity and mortality and surgical site infections are some of the common complications following cesarean section. this study aims to determine the effect of steri3x on the incidence of cesarean section ssi at regional one hospital.

postpartum infection is a major cause of maternal morbidity and prolonged hospitalization, and places a large burden on the healthcare system with an additional cost of $3,700 (olsen et al., 2010). surgical site infection (ssi) is one of the most common post-operative complications following cesarean section, with an incidence of 3-15% worldwide (zuarez-eaaston et al., 2017). wound dressings that are applied after closure of a surgical incision may help healing by providing physical support, protection from external contaminants, and by absorbing exudate (dumville et al., 2016). a new fda-approved microbicidial liquid adhesive, steri3x, has been shown to reduce the incidence of pin-tract infection by 100% in a randomized-controlled trial following external fixation in patients undergoing reconstructive surgery for deformity correction (pema, 2020). steri3x is reported to be effective against s. aureus (both mssa and mrsa), candida albicans, e. coli, p. aeruginosa, and candida auris, which are common organisms involved in dermatological infections. the most common organisms responsible for cesarean section ssi include enteric gram negative bacilli, enterococci, and group b streptococcus (gur et al., 2015). the advantage of this polymer following c-sections is unknown, and a larger study is needed to provide a more robust analysis. this study aims to determine the effect of steri3x on the incidence of cesarean section ssi at regional one hospital.

Eligibility criteria:
inclusion criteria: * age 16 years old or older * c-section patients only (primary, repeat, or stat) * diabetes, obesity ok to include (but not required) * patients receiving pcn for gbs prophylaxis ok to include (but not required) * application of steri3x immediately post-op exclusion criteria: * chorioamnionitis or other existing infection excluded (single maternal fever \>39 c, 2 maternal fevers \> 38, or clinical risk factors for chorioamnionitis) * patients receiving antibiotic treatment for existing or prior infection other than pcn for gbs prophylaxis * patients receiving prevena or other wound vac * rupture of membranes \>24 hours

Keywords: intrauterine infection, cesarean, postpartum endometritis, surgical site infection, postoperative wound infection
a study to assess the safety of administering cp-675,206 as a one hour infusion in patients with surgically incurable advanced melanoma

Conditions: Melanoma

Summary: this will show if cp-675,206 can be administered safely as an intravenous infusion lasting one hour. cp 675,206 already has been administered to 835 subjects over 1.0 - 7.5 hours.

this study was prematurely discontinued on april 28, 2008 because a concomitant phase 3 study met pre-specified futility criteria. the decision to close enrollment early was not based on any safety concerns.

Eligibility criteria:
inclusion criteria: * histologically confirmed melanoma that is surgically incurable note: prior therapies for melanoma, including cancer vaccines, are permitted but are not required. there is no limit to the number of prior regimens for melanoma a patient may have received. * evidence of at least one lesion * eastern cooperative oncology group (ecog) performance status 0-1 * ct scan of the brain with contrast or mri of the brain within 6 weeks prior to enrollment showing no evidence of active brain metastases. pet scans and pet/ct scans are also acceptable. exclusion criteria: * previous treatment with other anti ctla4 agents (eg, ipilimumab, mdx 010). * previously randomized to pfizer study a3671009: a phase 3, open label, randomized comparative study of cp 675,206 and either dacarbazine or temozolomide in patients with advanced melanoma. * history of chronic autoimmune disease (eg, addison's disease, multiple sclerosis, graves disease, hashimoto's thyroiditis, psoriasis, rheumatoid arthritis, systemic lupus erythematosus, hypophysitis, etc.). * history of inflammatory bowel disease (eg, crohn's disease or ulcerative colitis), celiac disease, or other chronic gastrointestinal conditions associated with diarrhea, or current acute colitis of any origin, and any history of diverticulitis (even a single episode) or evidence of diverticulitis at baseline, including evidence limited to ct scan only. * brain metastases that have not been adequately treated with surgery or stereotactic radiosurgery and have not been stable at least 3 months prior to enrollment.
performance evaluation of artificial intelligence screening model in coronary heart disease detection

Conditions: Coronary Heart Disease

Summary: to determine whether an integrated ai decision support can save time and improve accuracy of assessment of obstructive coronary heart disease (chd), the investigators are conducting a randomized controlled study of ai guided measurements of obstructive chd probability compared to clinical assessment in preliminary evaluations by physicians.

this is a randomized controlled trial (rct) evaluating the effectiveness of an ai-based decision support tool in the preliminary assessment of obstructive chd by physicians. retrospectively collected medical records of participants with chest pain or dyspnea will be randomly assigned to either guideline group or ai group after baseline assessment: there are three settings: 1. clinical intuition (baseline assessment) physicians assess obstructive chd probability without any external assistance. assessment relies solely on the physician's clinical judgment and experience. 2. guideline-based group (guideline group) physicians use a rf-cl table (risk factor weighted clinical likelihood table) to calculate the probability of obstructive chd. this approach aligns with current clinical guidelines to assist in decision-making. 3. ai-assisted group (ai group) physicians receive chd probability estimates and diagnostic recommendations from an ai model based on retinal photographs. the ai tool provides individualized obstructive chd probabilities, leveraging retinal biomarkers associated with cardiovascular risk. primary objective to evaluate whether ai-guided decision support could improves diagnostic accuracy of obstructive chd to a greater extent than standard clinical assessments, both compared to clinical intuition. secondary objective to assess whether ai-guided decision support reduces the time required to complete preliminary assessments of obstructive chd. participants, readers and randomization participants: case records of participants with chest pain or dyspnea, all underwent ct coronary angiography or invasive coronary angiography. readers: physicians performing preliminary evaluations of obstructive chd patients. randomization: participants and readers will be randomized into one of the groups (rf-cl or ai) after clinical assessment at baseline using block randomization to ensure balanced group sizes.

Eligibility criteria:
inclusion criteria: * individuals with symptoms of coronary heart disease * age range: 18-75 years old * can accept and cooperate with the examination and potential follow-up work after being selected for clinical trials exclusion criteria: * severe hypertension (\>180/110mmhg) * complex arrhythmia (atrial fibrillation, atrial flutter, frequent premature beats) * severe lung disease and chest malformation or surgery patients * acute myocardial infarction occurring less than 3 months ago * individuals with severe liver and kidney dysfunction and electrolyte imbalance

Keywords: obstructive coronary heart disease retinal images artificial intelligence
effects of regular exercise on adult asthma

Conditions: Asthma

Summary: the purpose of this study is to assess the effects of regular exercise on physical fitness, asthma control, and quality of life among adult asthmatics.


Eligibility criteria:
inclusion criteria: * diagnosis of asthma made by physician, or reimbursement for asthma medication from the national social insurance institution of finland (code 203), or patient fulfills the diagnostic criteria for asthma as outlined in the finnish guidelines for asthma management (käypä hoito -suositus 2006 and 2012) exclusion criteria: * fev1 \< 60 % of predicted in spirometry * pef variability \> 30 % at least 2 times during a 1-week monitoring period * use of bronchodilating medication at least 4 times daily * permanent, daily steroid tablet treatment * patients who exercise regularly already at baseline at least 3 times a week at least 30 min at a time * serious coronary heart disease * severe hypotension * severe heart failure * severe musculoskeletal disorder * dementia * physician-diagnosed chronic obstructive lung disease

Keywords: asthma exercise asthma control physical fitness quality of life
a study to assess stroke risk among users of typical versus atypical antipsychotics stratified by broad age group

Conditions: Stroke

Summary: the purpose of this study is to extend the recent food and drug administration (fda) sentinel tabulations regarding stroke risk among new users of typical and atypical antipsychotics to participants who were aged 18-64 years and did not have dementia to participants aged 65 years and older regardless of dementia status.


Eligibility criteria:
inclusion criteria: for entry event of an initial drug exposure: * first exposure to the particular drug(s) in the past 183 days (index date) * had at least 183 days of continuous observation time prior to index * exactly 0 condition occurrences of 'cancer' any time in the 183 days before or on the index date * exactly 0 condition occurrences of 'stroke' any time in the 183 days before or on the index date * exactly 0 exposures to any other typical or atypical antipsychotics any time in the 183 days before or on the index date
oracell™ vs. connective tissue in miller class 3 defects

Conditions: Gingival Recession

Summary: the purpose was to compare root coverage outcomes between autogenous connective tissue graft (ctg) and decellularized human dermis (oracell™) in areas of facial gingival recession.

twenty-four non-smoking, healthy patients, with 2mm or greater facial gingival recession at a minimum of one site that classified as a miller class i, ii, or iii recession defect were included. patients were randomly assigned to either control (ctg) or oracell™ (test) groups, which were treated with identical surgical techniques. all root coverage clinical parameters were evaluated at baseline, 3-, and 6-months.

Eligibility criteria:
inclusion criteria: 1. patients must be between 18 and 80 years old, with recession present in one quadrant as either single or multiple buccal vertical recession sites 2. the defect must be at least 2mm in length, (measured from the cej to the midfacial gingival margin) and classified as either miller class i, ii or iii 3. study is limited to vital and nonvital incisors, canines, and premolars 4. if teeth adjacent to the site to be treated had recession as well, they were included in the grafting procedure but not included in measurement 5. plaque control defined as modified o'leary index of 85% was established before surgical intervention 6. only sites with probing depths of 3mm or less and no bleeding on probing were accepted for surgery exclusion criteria: 1. subjects who smoke more than ten cigarettes per day or use nicotine replacement therapy 2. history of previous history of surgery performed at surgical sites included in study 3. subjects who have uncontrolled or poorly controlled systemic conditions that could compromise or contraindicate periodontal surgery 4. non-english speakers 5. pregnant or lactating females 6. immunosuppressant medications

Keywords: gingival recession connective tissue graft oracell decellularized dermis periodontics
links between perception of temporal order judgment and causality in schizophrenia

Conditions: Schizophrenia

Summary: people with schizophrenia show disturbances in the perception of time. among these alterations are the perturbations of the temporal order judgment. they are characterized by the fact that, as opposed to the general population, people with schizophrenia require a longer time interval between two successive stimuli to estimate which of the two events appeared first. if these alterations are now well documented, their consequences remain little explored. among these consequences could however appear distortions of the judgment of causality (likely to underlie certain delusional interpretations) as well as a distressing experience of loss of the continuity of the lived experience (that could contribute to the alterations basic of self-awareness).

the objective of our work lies in the study of the links between temporal sequencing, subjective perception of time and causality. to carry out this work, the investigators will rely on an experimental paradigm (derived from michotte's paradigm) which makes it possible to explore the links between temporal sequencing and perception of causality, validated in the normal subject. subjective consequences of these alterations will be explored using a phenomenological-inspired clinical scale (eawe time-scale items)

Eligibility criteria:
inclusion criteria: subjects with schizophrenia: * age from 18 to 45 years * diagnosis of schizophrenia according to dsm v criteria * french mother tongue * psychotropic treatment unchanged during the month preceding the inclusion * stable symptomatology * normal or corrected visual acuity (\> 0.8 at snellen scale) and normal color vision * patients who gave informed consent to participate in the study control subjects (healthy volunteers): * age from 18 to 45 years * absence of neurological and psychiatric disorders * french mother tongue exclusion criteria: * recent addiction and abuse of cannabis or any other substance (according to dsm v criteria) * neurological disorders of vascular, infectious or neurodegenerative origin * taking somatic drugs with a cerebral or mental impact (eg corticosteroids) * disabling sensory disturbances, and in particular visual acuity * participation in a neuro cognitive remediation program * schizophrenia resistant to neuroleptic treatments * persons protected by law (pregnant women, minors, major under guardianship ...)
experience of hospital students in the odontology department

Conditions: Occupational Stress

Summary: during their studies, the dental students of brest (france) learn their future profession by working in the dental university hospital, from the fourth academic year. this clinical activity is considered as both a source of satisfaction and stress by most of the students. the main objective of this study is to investigate the experience of brest dental students through a qualitative methodology, with individual interviews, followed by an analysis by grounded theory (paillé, 1994).

during their studies, the dental students of brest (france) learn their future profession by working in the dental university hospital, from the fourth academic year. this clinical activity is considered as a source of satisfaction by most of the students. they are also reassured because they know that they will easily find an employment at the end of their studies. however, the clinical activity can also create a stress among the students, which varies with their progress in their studies (polychronopoulou et divaris, 2009). other sources of stress could also be identified. this multifactorial stress can influence their well-being, their practices and their relationships with patients. the stress and satisfactions of the dental students have mainly been studied by some questionnaires (inquimbert et al., 2017). the main objective of this study is to investigate the experience of brest dental students through a qualitative methodology, with individual interviews, followed by an analysis by grounded theory (paillé, 1994). this type of research can enable us to keep a broad approach of students' experience and to stay faithful to it.

Eligibility criteria:
inclusion criteria: * volunteer students of brest dental university hospital, having given his/her consent * adult students of brest dental university hospital, in fourth, fifth and sixth academic year exclusion criteria: * students in work-stoppage * students in erasmus program * non-volunteer students or students refusing to give his/her consent

Keywords: stress well-being anxiety confidence satisfaction
changes of pain and functional parameters in back pain patients over time

Conditions: Changes Over Time in Pain and Functional Parameters

Summary: back pain affects patients' daily life. patients can suffer from various symptoms which appear intermittent or permanent; pain, sensory malfunction, reduction of muscular strength and coordination. therefore, patients are impaired in participation and activity. physiotherapy is recommended to improve those symptoms and to positively affect the cause of the problem. however, some patients do not benefit from physiotherapeutic treatment and require a surgery. the investigators intend to attend patients suffering from back pain and to document the changes of pain and functional parameters over a period of 6 months. the investigators include pre-operative, post-operative or non-operated patients which allows to discuss the different treatment options and its effects.

to assess pain and functional parameters physicians, medical staff and physiotherapist often use subjective clinical testings which impede the comparability of testings over time, between testers and between subjects. therefore, a second aim of this study is to evaluate each subjective clinical test with a standardized objective measurement tool.

Eligibility criteria:
inclusion criteria: * appointment at the neurosurgery department due to back pain * german speaking * willingness to see a physiotherapist * willingness to participate in 3 measurements over 6 months exclusion criteria: * no appointment at the neurosurgery department due to back pain * not german speaking * no willingness to see a physiotherapist * no willingness to participate in 3 measurements over 6 months
preoperative risk score for postoperative right ventricular dysfunction in adult cardiac surgery

Conditions: Right Ventricular Dysfunction

Summary: right ventricular dysfunction (rvd) is common following cardiac surgery, and it is characterised by impaired right ventricular function that can lead to decreased cardiac output and hemodynamic instability. rvd is consistently associated with poor outcomes. the mechanisms behind rvd post-surgery involve changes in preload, after load, and rv contraction. factors linked to higher incidence of postoperative rvd include decreased tricuspid annular plane excursion (tapse), elevated preoperative pulmonary artery pressure, lung diseases, duration of extracorporeal circulation, and left valve surgery. while predictive scores for rvd exist for left ventricular assist device (lvad) patients, no such models are available for other cardiac surgeries. identifying specific predictors could lead to models that identify high-risk patients, allowing for tailored monitoring and treatment strategies. the primary aim of this study is to create a preoperative risk score for predicting the development of right ventricular dysfunction following adult cardiac surgery through a retrospective analysis on patients who underwent heart surgery.

postoperative rvd will be defined as: - echocardiographic parameters suggestive of rvd (at least 2 out of 3): tapse \ 3 cm (measured from the septum to the free wall). and - need for inotropic and/or pulmonary vasodilator drug support and/or mechanical support. data will be collected retrospectively on: demographic characteristics; basic patient characteristics (weight, height, body mass index -bmi, etc.); preoperative pharmacological therapy; preoperative comorbidities; abnormalities in blood tests; chest x-rays and ecgs; abnormalities in coronary angiography and carotid ultrasound; preoperative echocardiographic examination: tapse, left ventricular ejection fraction- lvef, valvular pathologies, pulmonary artery systolic pressure- paps, pericardial effusion; type of surgical intervention; occlusion of the posterior interventricular coronary artery (acute or chronic); duration of the surgical procedure; duration of extracorporeal circulation; non-revascularized right coronary artery disease; blood product transfusions; postoperative pharmacological therapy (with particular regard to the use of inotropes/pulmonary vasodilators/vasopressors); postoperative echocardiographic examination: tapse; rvfac; right ventricular dilation at end-systole; postoperative complications; intensive care unit (icu) length of stay and hospital length of stay.

Eligibility criteria:
inclusion criteria: * age \> 18 years * elective or urgent cardiac surgery at campus biomedico between january 2016 to december 2023 * postoperative echocardiogram execution * asa class i-iv exclusion criteria: * age \< 18 years * inotropic therapy at the time of surgery