Kornimate/medical-research-clean huggingface dataset:
the use of diluted povidone iodine irrigation in spine surgery

Conditions: Surgical Site Infection

Summary: the purpose of the study is to determine whether diluted povidone iodine solution used to irrigate surgical wounds during spine surgery decreases the incidence of surgical site infections.

post-operative infections in spine surgery have been extensively investigated in the literature. these investigations focus on the efficacy of using peri-operative antibiotics, povidone iodine skin preparations, the effects of shaving around the surgical sit, and the use of intra-operative diluted povidone iodine wound irrigation in preventing post-operative infections. povidone-iodine is a complex of polyvinyl pyrrolidine and tri-iodine ions widely used as an antiseptic agent. it has bactericidal activity against a wide spectrum of pathogens, including methicillin-resistant staphylococcus aureus (mrsa). the safety of its use intra-operatively has been evaluated in animal studies and also supported through randomized controlled trials in spinal surgery and in other surgical subspecialties. the purpose of this study is to evaluate the efficacy of the intra-operative use of diluted povidone iodine solution in reducing post-operative infections when used for irrigating surgical incisions during spinal surgery compared with 0.9% sodium chloride irrigation solution (i.e. normal saline solution). the primary outcome measure will be seen as a reduction in the number of post-operative infections. as a result and although not directly measured, it is suspected that a reduction in post-operative infections may result in quicker healing with fewer complications and pain.

Eligibility criteria:
inclusion criteria: * age of 18-75 * undergoing posterior surgical spinal procedure for degenerative spine disease, extra-dural tumors, trauma, or spinal deformity * no obvious potential infective focus * patient willing to enroll exclusion criteria: * age \ 75 * identified infective focus in the body, including furuncles,or acne at surgical incision site * patient with discitis or spinal osteomyelitis * dural tear * potential use of bone morphogenic protein (bmp) * iodine hypersensitivity * out of province patients due to difficulty in arranging follow up visits * minimal invasive spine surgical procedure (miss) due to difficulty of having diluted betadine solution contact soft tissue with the use if miss retractors * pregnancy * inability to provide informed consent
virtually assisted home rehabilitation after acute stroke-2

Conditions: Stroke

Summary: the purpose of this study is to assess feasibility of a virtual rehabilitation program in stroke patients and to assess treatment effects, patient goal attainment with self-guided rehabilitation activities, barriers to and facilitators of telerehab, hospital readmission events, and social determinants of health


Eligibility criteria:
inclusion criteria: * informed consent provided by the subject or legally authorized representative. * diagnosed with hemorrhagic or ischemic stroke * pre-stroke mrs is less than 3 * qualifying stroke event must be confirmed by ct or mri * recommended to participate in self-guided or in-person rehabilitation activities by a physician or rehabilitation therapist * must have sufficient cognitive and language abilities to comprehend verbal commands and to carry out the study assessments * able to access the internet * mild-moderate impairments in motor or cognitive function exclusion criteria: * history of neurological or other disease resulting in significant functional impairment (e.g. parkinson's disease, motor neuron disease, moderate dementia, arthritis, contractures or fixed anatomical abnormality). * subjects with a severe comorbid disorder that has reasonable likelihood of limiting survival to less than 6 months. * any other conditions that, in the opinion of the investigators, would preclude safe and/or effective participation.

Keywords: telerehabilitation
sibling-support for adolescent girls (ssage)

Conditions: Anxiety; Depression; Mental Illness

Summary: forcibly displaced adolescents face increased risks for mental illness and distress, with adolescent girls disproportionately affected in part due to the heightened gender inequity that often accompanies forced displacement. although the family unit has the potential to prevent mental illness and promote healthy development in adolescents, few family interventions have employed a gender transformative approach or included male siblings in an effort to maximize benefits for adolescent girls. therefore, the investigators propose to assess an innovative whole-family and gender transformative intervention-sibling support for adolescent girls in emergencies (ssage)-to prevent mental health disorders among adolescent girls in colombia who were recently and forcibly displaced from venezuela. the proposed r34 study will adapt the ssage curriculum through human-centered design with a range of stakeholders, including venezuelan refugees, colombian returnees and relevant civil society organizations. the proposed study will then employ a hybrid type 1 effectiveness-implementation pilot randomized control trial (rct) to test the program's effectiveness and mechanistic pathways as well as to explore determinants of implementation in order to establish the feasibility, acceptability, and fidelity of ssage. to address these aims, the investigators will enroll 180 recently arrived, forcibly displaced adolescent girls in an rct and examine the program's effectiveness on the prevention of mental illness (through reduction in anxiety, depression, interpersonal sensitivity, and somatization symptoms) one-month post-intervention. the investigators will use contextually adapted and piloted measures to collect additional data on the hypothesized mechanistic pathways, including family attachment, gender equitable family functioning, self-esteem, and coping strategies. the implementation evaluation will employ mixed methods to assess the program's feasibility, acceptability, fidelity and barriers and facilitators to successful implementation. potential findings can support humanitarian program implementation, as well as inform policy to support adolescent girls' mental health and to prevent the myriad disorders that can arise as a result of exposure to displacement, conflict, and inequitable gender norms in their households and communities.


Eligibility criteria:
inclusion criteria: * live with a male and female caregiver and an adolescent male sibling or relative * immigrated to colombia within the last year * are available, along with their family members, to participate in the ssage intervention for three months * are available to participate in survey questionnaires immediately before and one month after the intervention exclusion criteria: * none

Keywords: mental illness adolescent girls forcibly displaced populations randomized-controlled trial implementation science family functioning gender inequity
the anca vasculitis questionnaire (aav-pro©)

Conditions: Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss) (EGPA); Churg-Strauss Syndrome (CSS); Granulomatosis With Polyangiitis (Wegener's) (GPA); Wegener Granulomatosis (WG); Microscopic Polyangiitis (MPA); ANCA-Associated Vasculitis (AAV); Vasculitis

Summary: the aim of this project is to develop a disease specific patient reported outcome measure (prom) for patients with aav (the aav-pro). investigators are developing and validating a questionnaire to assess quality of life in patients with anca-associated vasculitis (aav). patients with aav have inflammation in the small blood vessels leading to involvement of a range of organs and can suffer from ongoing disease activity or treatment side effects. quality of life can be measured by patient reported outcome measures (proms).

patients with anca-associated vasculitis have inflammation in the small vessels that impact a range of organs and investigators understand that patients may suffer ongoing disease activity, as well as side effects from the treatments. assessing patients quality of life can be an important tool for conducting clinical trials for new treatments and medications. quality of life can be measured by questionnaires called "patient reported outcome measures" (prom). what is a patient-reported outcome? patient-reported outcomes, or pros, are patients' feedback on what they are feeling or what they are able to do as participants are dealing with a chronic disease . patient-reported outcomes are important because they provide doctors and researchers information about patients' quality of life. questionnaires can be designed to measure specific pros that are of specific importance to a disease and can provide much needed information on evaluating the effectiveness of health care. the aim of this survey is to develop a disease specific patient reported outcome measure, or prom, for patients with aav. a small group of investigators and patient-partners developed this survey for people with anca-associated vasculitis (the aav-pro). investigators will invite patients with aav to complete the questionnaire they have designed, called the aav-pro. by analysing how people fill in the questionnaire, investigators will be able to find out how well the questions work, and whether they need to ask all of them.

Eligibility criteria:
inclusion criteria: * registered in the vasculitis patient-powered research network (v-pprn) * patients greater than 18 years of age * diagnosis of anca-associated vasculitis including: eosinophilic granulomatosis with polyangiitis (also called churg-strauss syndrome), granulomatosis with polyangiitis (also called wegener's granulomatosis or gpa), microscopic polyangiitis (mpa)
centralized pan-south african survey on the undertreatment of hypercholesterolaemia

Conditions: Undertreatment of Hypercholesterolaemia

Summary: this is a multi-centre survey of patients who are currently on lipid lowering pharmacological treatment in south africa.


Eligibility criteria:
inclusion criteria: * subject must be 18 years of age or older of either gender or race. * subject must provide informed consent and comply with the survey procedures. * subject is on lipid lowering drug treatment for at least 3 months, with no dose change for a minimum of 6 weeks. exclusion criteria: * subjects who are unwilling or unable to provide informed consent.

Keywords: pan south african survey on the undertreatment of hypercholesterolaemia
the effect of different diets on arterial stiffness in obese patients on semaglutide

Conditions: Obesity; Weight Loss

Summary: in patients initiating semaglutide for weight management, the objective is to compare the effect of the mediterranean diet and the high protein/low carbohydrate (hp/lc) diet cv parameters, namely arterial stiffness, measured by carotid-femoral pulse wave velocity (cfpwv), and visceral adipose tissue, in addition to other metabolic indicators.

this is a 6-month open label pilot rct that will be conducted on lebanese subjects with obesity, upon the initiation of semaglutide for medical weight management, as recommended by their physician. patients will be randomized to 2 treatment arms: med diet and hp/lc diet. med diet will be hypocaloric, allowing the same energy restriction, of 500 kcal/d, while the hp/lc diet will be ad libitum. participants will be recruited from the endocrine clinics at aub-mc, and from satellite clinic next in beirut. brochures and posters of the trial will be available in the clinic waiting areas. patients of both participating and non-participating physicians will be recruited in the study.

Eligibility criteria:
inclusion criteria: * men and premenopausal women, 18-49 years, with obesity defined as bmi ≥ 30 kg/m2 * upon the initiation of semaglutide (within the first 1-4 weeks) for medical weight management, for clinical purposes, as advised by the primary physician * able to commit for a 6-month trial visits exclusion criteria: * pregnant women * patients who are taking or have taken other weight reducing drug therapies in the previous 6 months * patients who have undergone metabolic weight loss surgery * patients known to have diabetes (hba1c ≥6.5% at screening) * patients with uncontrolled hypertension * patients with uncontrolled cardiac disease, pulmonary, renal or liver diseases, active cancer or psychiatric diseases * patients with excessive alcohol intake, defined as ≥ 2 glasses per day * patients known to have uncontrolled/ untreated thyroid disorders. * patients with cushing disease or polycystic ovaries, and those with neuro-endocrine or drug induced obesity (such as anti-psychotic, steroids, hormonal therapy): such patients are resistant to weight loss, and they need treatment of their primary disease and/or cessation of the culprit medication to lose weight * patients with untreated gout * patients who have undergone bariatric surgery
thoracolumbal interfascial plane block versus erector spinae plane block for lumbar posterior decompression stabilization

Conditions: Lumbar Posterior Decompression

Summary: this study aimed to found out the comparison of perioperative analgesia effectiveness between thoracolumbal interfascial plane block with erector spinae plane block in lumbar posterior decompression and stabilization.

this is a double blind randomized controlled trial. forty subject will be recruited with non-probability consecutive sampling method. subjects who meet all inclusion criteria and do not have exclusion criteria will be asked to sign the informed consent form before included in this study. subjects will be randomized into two groups. the first group is the group who will get bilateral thoracolumbal interfascial plane block after general anesthesia and the second group will be the group who will get bilateral erector spinae plane block after general anesthesia. after surgery, pain scale, time to first morphine dose, total morphine consumption in 24 hours, cardiovascular stability and adverse events will be recorded for both group.

Eligibility criteria:
inclusion criteria: 1. age 18 - 65 years old 2. patients schedule for elective posterior decompression and stabilization lumbar spine surgery 3. asa i - iii 4. decompression and posterior stabilization's patients who didn't caused by infection or abscess exclusion criteria: 1. patients who refuse to participate in this study 2. body mass index \ 27,0 kg/m2 3. patient with history of chronic opioid 4. patient with coagulation disorder 5. patient with cognitive disorders 6. infection at the injection area

Keywords: thoracolumbal interfascial plane block erector spinae plane block lumbar posterior decompression and stabilization
corneal flap thickness planed vs measured after lasik by using tree different systems cut

Conditions: Refractive Errors

Summary: determine the flap thickness created by femtosecond laser or a mechanical microkeratome using in vivo confocal microscopy and compare measured versus intended flap thickness.

eighty-six eyes had undergone lasik were examined, al within 2 weeks to 1 month after surgery. study involved 3 treatment groups: one with 30 eyes of 15 patients, corneal flaps were created with the microkeratome femtosecond laser 15 khz 100μm (intralase corp, irvine, calif.), one with 30 eyes of 15 patients, corneal flaps were created with mechanical microkeratome (hansatome 160μm (chiron vision corp, claremont, calif) and one with 26 eyes of 13 patients, corneal flaps were created with mechanical microkeratome k3000 130μm ( bd ophthalmic systems, waltham, mass) . a central scan of the total corneal thickness was taken with the confocal microscope (confoscan 4, fortune technologies, italy) before and at 2 weeks and 1 month after surgery. corneal epithelial thickness and the anterior stroma morphology were analyzed by using the navis software v. 3.5.0 (nidek, multi-instrument diagnostic system, japan).

Eligibility criteria:
inclusion criteria: * patients ask for lasik surgery * patients with stable refraction in the last year * patients without systemic and ocular disease * patients with 500 microns in pachymetry * normal topography exclusion criteria: * patients cannot attend their appointments * residual, recurrent or active ocular disease * previous ocular surgery except lasik * autoimmune or connective tissue disease * pregnancy

Keywords: lasik confocal microscopy flap
effect of tolvaptan on renal plasma flow (rpf) and glomerular filtration rate (gfr) in adpkd

Conditions: Polycystic Kidney, Autosomal Dominant

Summary: polycystic kidney disease (adpkd) is a common genetic disorder, characterized by the formation of cysts in the kidneys, causing gradual renal function-loss. previous studies have shown that, reduced glomerular filtration rate (gfr) and renal plasma flow (rpf) play a role in the progression of renal disease in adpkd. tolvaptan is a vasopressin 2 antagonist, which seems to reduce the growth of total kidney volume (tkv) and the decline in e-gfr in adpkd. the mechanism is not fully understood and could, at least partly, be caused by stimulation of the renal blood flow. the purpose of this trial is to investigate if tolvaptan´s improve renal blood flow and glomerular filtration in adpkd, in a randomized, cross-over, double-blind, placebo-controlled study.

the aim is to measure the acute effects of tolvaptan on: 1. renal hemodynamics (rpf, gfr, filtration fraction ((ff)) and renovascular resistance ((rvr)) 2. blood pressure (central blood pressure ((cbp)) and brachial blood pressure bbp) 3. several vasoactive hormones (plasma renin ((prc)), plasma angiotensin ii ((p-ang-ii)), plasma aldosterone ((p-aldo)), plasma vasopressin ((p-avp)) in patients with adpkd.

Eligibility criteria:
inclusion criteria: * age \> 18 years * diagnosis with adpkd * informed consent * contraception for fertile women exclusion criteria: * renal transplantation * operation in the kidney * diabetes mellitus * neoplastic conditions * pregnancy, nursing * unwillingness to participate * egfr \> 30 * intolerance towards tolvaptan * alcohol or medical abuse, * bp \>\>170/110 blood pressure despite regulation

Keywords: cysts, kidneys
using technology to optimize collaborative care management of depression in urban and rural cancer centers, scope

Conditions: Depression; Hematopoietic and Lymphoid Cell Neoplasm; Malignant Solid Neoplasm

Summary: this study compares the effectiveness of technology-enhanced collaborative care management (t-cocm) to usual collaborative care management (u-cocm) in achieving fidelity to processes of care and reducing depression symptoms in patients currently receiving cancer treatment. cocm is a population-based, integrated care approach, where care managers, who are clinicians (typically clinical social workers), deliver behavioral treatments, coordinate psychosocial care, monitor outcomes, and adjust treatment with the input of a psychiatric consultant. the use of t-cocm may improve the treatment of depression and improve patient outcomes and quality of life.

outline: patients are randomized to 1 of 2 arms. arm i (t-cocm): patients use the t-cocm digital app platform and clinic care managers use the t-cocm web-based patient registry platform to support delivery of collaborative care. patients complete surveys at baseline, 3, 6 and 9 months. some patients also participate in an interview or focus group about their user experience with the t-cocm digital platform. care managers also participate in interviews or focus groups regarding their experience with cocm and the newly developed web-based platform. arm ii (u-cocm): patients receive usual care and clinic care managers deliver usual cocm. patients complete surveys at baseline, 3, 6 and 9 months.

Eligibility criteria:
inclusion criteria: * patients receiving active treatment (surgery, chemotherapy, immunotherapy, targeted therapy, stem cell transplant, hormone therapy, radiation therapy) for a malignancy * \>= 18 years old * participants must be ambulatory for clinical care visits * clinically significant depression (patient health questionnaire-9 (phq-9) \>= 10 with at least one cardinal symptom \> 1) * access to smartphone, tablet, or computer with internet access; or landline * patients who do not have a smartphone will be offered assistance in obtaining a free smartphone through the government-sponsored lifeline phone program for low-resourced individuals exclusion criteria: * advanced cancer or other condition that limits remaining life expectancy to less than 9 months * already engaged in or needing immediate specialty mental health care e.g., for bipolar disorder or schizophrenia * inability to speak and read english
study on the impact of education website on the quality of outpatient bowel preparation for colonoscopy

Conditions: Colon Cancer

Summary: colorectal cancer (crc) is a common and life threatening condition that will affect one in thirteen individuals. colonoscopy is the most commonly used procedure to identify colorectal malignancies or precancerous lesions at an earlier stage, which affords an opportunity for cure. however, low level of bowel cleanliness hinders polyp detection and therefore can limit colonoscopy effectiveness. historically, the majority of the studies have focused on pharmacological factors to optimize bowel preparation quality. recently, non-pharmacological factors have been found to have significant increases in bowel preparation quality. the purpose of this study is to evaluate the effectiveness of web-based instructions vs. the historical phone/letter instructions given to patients planning to have a colonoscopy.

this study is a prospective randomized trial. four hundred and fifty consecutive eligible patients will be randomized to ideally have two hundred and twenty five patients in each arm. those who will have traditional paper based instructions and those who will be using an online system. both groups will receive their instructions by the research assistant prior to leaving the office after being consented. the paper based instructions will be given as a handout and those in the online group will receive their bowel preparation instructions via an email sent by a scheduling assistant

Eligibility criteria:
inclusion criteria: * age 19 or greater * patients scheduled for a colonoscopy using a doctors "normal prep" as outpatients * willing to participate by filling out the survey * must be able to read and understand english * must have ability to use email, have a functioning email account, and are willing to be contacted by email. exclusion criteria: * unable to speak english * unwilling to participate in reading online materials