Kornimate/medical-research-clean huggingface dataset:
tai chi for behavioral modification among individuals with metabolic syndrome

Conditions: Metabolic Syndrome

Summary: this is the randomized trial to explore the effect of behavioral modification program (tai chi vs. self management) on adults with metabolic syndrome. the outcome variables include health behavior, metabolic syndrome indicators, quality of life.

1. venue: the individuals with diagnosis of metabolic syndrome are recruiting from university hospital outpatient clinic or primary clinic. 2. inclusion criteria: diagnosed of metabolic syndrome, agree to participate either programs, no history of participating regular exercise program past 6 months. 3. intervention: the behavioral modification program consisting of tai chi exercise (twice a week for 12 weeks) and self-management program (6 sessions every two weeks) is provided to the participants who randomly assigned to either group. short form yang style tai chi (16 movements) were led by trained tai chi practitioners, and self-management program were provided by nurse educators.

Eligibility criteria:
inclusion criteria: * diagnosis of metabolic syndrome * adults who agree to participate either behavioral modification programs for 12 weeks * be able to understand the questionnaire and follow the exercise or education program exclusion criteria: * who attend regular exercise program past 6 months
effects of ic with and without met on upper trapezius trigger points

Conditions: Upper Trapezius Trigger Points

Summary: the aim of the study is to check the effects of ischemic compression with and without muscle energy technique on pain, range of motion, and functional disability on myofascial trigger points in the upper trapezius. in previous studies, muscle energy technique and ischemic compression are compared with different conventional and combined therapy approaches, including most of the techniques used to treat trigger points in the upper trapezius. no study has evaluated the effects of ischemic compression with and without muscle energy technique on pain, range of motion, and functional disability on myofascial trigger points in the upper trapezius. the outcome measures are a numeric pain rating scale, universal goniometer and neck disability index questionnaire.


Eligibility criteria:
inclusion criteria: * both gender aged 18 to 50 years (40) * participants with active myofascial trigger points in the upper trapezius diagnosed by a senior physiotherapist on the basis of travel and simon criteria will be randomly allocated into two clinical groups. * taut band having palpable nodule within upper trapezius muscle * pain produced in a specific pattern which is radiating in character when firm pressure is applied on trigger points exclusion criteria: * trauma (whiplash injury) * injury to cervical spine * cervical spine surgery * cervical myelopathy and radiculopathy * osteoporosis of the cervical spine * cervical myeloma * complex regional pain syndrome * patients with the h/o any neurological, rheumatology and other serious medical illnesses.
intrastromal corneal ring segment implantation in 219 keratoconic eyes at different stages

Conditions: Keratoconus

Summary: the purpose of this study is to properly analyse the visual and refractive outcomes of implantation of keraring intrastromal corneal ring segment (icrs) at the different stages of keratoconus.


Eligibility criteria:
inclusion criteria: * patients who had keratoconus * contact lens intolerance and clear cornea. * the maximum keratometric reading was less than 60.00 diopters (d) * the minimum corneal thickness more than 300 μm. exclusion criteria: * acute or grade iv keratoconus. * previous corneal or intraocular surgery. * cataract, history of glaucoma or retinal detachment, macular degeneration or retinopathy, neuro-ophthalmic diseases, and history of ocular inflammation

Keywords: keratoconus intrastromal corneal ring segment to evaluate the visual and refractive outcomes of intrastromal corneal ring segment in keratoconic eyes at different stages
efficacy and safety of different concentrations of zk245186 in atopic dermatitis (ad)

Conditions: Atopic Dermatitis

Summary: the purpose of this study is to evaluate the efficacy and safety of three concentrations of a development drug compared to placebo in the treatment of atopic dermatitis.


Eligibility criteria:
inclusion criteria: * diagnosis of atopic dermatitis according to hanifin and rajka criteria * body surface area affected by atopic dermatitis at or less than 15% at start of treatment exclusion criteria: * pregnancy and breast-feeding * conditions that may pose a threat to the patient or effect the outcome of the study * wide-spread atopic dermatitis (ad) requiring systemic treatment * immuno-compromized conditions * at least 2 weeks after local ad treatment and treatment with systemic antibiotics * at least 1 month after systemic ad treatment
impact of emotional mimicry and oxytocin on frontotemporal dementia

Conditions: Frontotemporal Dementia

Summary: this study will evaluate the effects on emotions and neural activity of a one time dose of intranasal oxytocin vs. placebo in patients with ftd and healthy controls.

frontotemporal dementia (ftd) and pick's disease cause changes in personality, behaviour, and emotional responses. the usual treatments for frontotemporal dementia focus on reducing agitation and aggressive behaviours. however, these drugs do not help all patients who experience blunting of emotion and loss of empathy. this study will evaluate the effects on emotions and neural activity of a one time dose of intranasal oxytocin vs. placebo in patients with ftd and healthy controls.

Eligibility criteria:
inclusion criteria: patients: * ages 30-85 * meet consensus criteria for probable behavioural variant ftd (bvftd) controls: * age and sex matched with patients * mini-mental state exam (mmse) scores \>27 exclusion criteria: patients: * history of stroke * intracranial haemorrhage or other medical or neurological disorder apart from ftd that could affect cognition * diagnosis of bipolar disorder or schizophrenia not better accounted for by the diagnosis of ftd * cognitive impairment that precludes comprehension of task instructions * contraindication to mri scanning * severe language or memory deficits that preclude participation in the study visits and measures * females who are pregnant or breastfeeding (a pregnancy test will be done on females who have not completed menopause). * uncontrolled hypertension * bradycardia (rate \ 100 bpm) * current use of prostaglandins controls: * history of stroke * intracranial haemorrhage or other medical or neurological disorder * diagnosis of bipolar disorder or schizophrenia * cognitive impairment that precludes comprehension of task instructions * contraindication to mri scanning * severe language or memory deficits that preclude participation in the study visits and measures * females who are pregnant or breastfeeding (a pregnancy test will be done on females who have not completed menopause). * uncontrolled hypertension * bradycardia (rate \ 100 bpm) * current use of prostaglandins

Keywords: frontotemporal dementia emotion oxytocin fmri
selected site pacing to avoid phrenic nerve stimulation in cardiac resynchronization patients with quadripolar left ventricular leads

Conditions: Heart Failure

Summary: cardiac resynchronization (crt) therapy is well established for treatment of patients with severe heartfailure, reduced left ventricular (lv) function and ventricular dyssynchrony. roughly 1/3 of crt patients do not improve after crt implant. one possible reason is interruption of biventricular pacing. this might be caused by several conditions, including elevated left ventricular (lv) pacing thresholds or presence of phrenic nerve stimulation (pns). crt devices with quadripolar lv leads offer 10 lv pacing vectors to choose from. it's the aim of this prospective observational study to investigate efficacy and reliability of cardiac resynchronization therapy (crt) with quadripolar left ventricular leads. hypothesis: in more than 90% of patients, who received a crt system with quadripolar lv lead, at least one acceptable lv lead vector is available.

definition of an acceptable lead vector: any lv pacing vector that complies in both tested body positions (left lateral position and sitting) with both criteria: 1. phrenic nerve stimulation threshold is at least twice as high as lv pacing threshold 2. lv pacing threshold is less or equals 2.5volts (v) @0.5 milliseconds (ms)

Eligibility criteria:
inclusion criteria: * indication for implantation of a crt-d * age \>= 18 years * written informed consent exclusion criteria: * already implanted lv or coronary sinus lead * previous unsuccessful lv lead implant attempt * patient is eligible for heart transplantation * comorbidities that results in life expectancy of less than 12 months * known pregnancy * inability to provide written patient informed consent * participation to another study with active treatment arm (i.e. randomized studies etc...) * patient is not willing or is not able to visit the study center for the study assessments within the first 3 months after implant * patient is not able to understand or answer the quality of life questionaire

Keywords: hear failure cardiac resynchronization crt-d quadripolar
the impact of covid-19 on patients waiting for knee surgery

Conditions: Osteoarthritis, Knee; Osteochondral Defect; Cartilage Injury; Cartilage Damage; Knee Injuries; Knee Injuries and Disorders

Summary: the covid-19 pandemic has led to the postponement and cancellation of elective orthopaedic surgeries worldwide. these delays to elective procedures combined with ongoing demand have led to increasingly longer waiting list times. this cross-sectional pilot study aims to investigate the change in patients' perceptions of knee pain and function since being waitlisted for surgery. a bespoke survey will be administered to eligible patients over the phone from trafford general hospital, manchester. the survey will also investigate the coping mechanisms and the preventative measures patients are taking to manage symptoms during the pandemic, and question what kinds of communication and support patient would like to be offered whilst waiting for treatment. this study will improve clinicians' and researchers' understanding of how patients are coping with symptoms during this pandemic, and provide information on how to better support patients who are waiting for knee surgery. this information could be used to enhance orthopaedic care during, and in the aftermath, of this pandemic. the information gathered in this study may also be used to inform a larger multi-centre study.


Eligibility criteria:
inclusion criteria: * patients identified by a consultant orthopaedic surgeon as being on a waiting list for surgery on their knee. * patients identified by a consultant orthopaedic surgeon who are experiencing a delay to their knee surgery as a result of the covid-19 pandemic. * patients over 18 years old. exclusion criteria: * patients who are no longer waiting for their surgery (e.g. surgery performed elsewhere or patient has changed their mind about undergoing surgery). * patients who are on a waiting list for any surgery other than surgery of the knee. * patients who are on a waiting list for surgery at a hospital which is not a part of manchester university nhs foundation trust. * patients who cannot read and speak english. * patients who cannot complete the survey over the phone. * patients who cannot give informed consent due to cognitive impairment (e.g. dementia or similar cognitive condition).

Keywords: covid-19 knee surgery knee pain knee function coping mechanisms
organized program to initiate lifesaving treatment in hospitalized patients with heart failure (optimize-hf)

Conditions: Heart Failure, Congestive

Summary: this program is designed to improve medical care and education of hospitalized patients with heart failure and accelerate the initiation of evidence-based heart failure guideline recommended therapies by administering them before hospital discharge. a registry component focusing on admission to discharge and 60- to 90-day follow-up is designed to evaluate the demographic, pathophysiologic, clinical, treatment, and outcome characteristics of patients hospitalized with heart failure.


Eligibility criteria:
inclusion criteria: * hospitalized for episode of worsening heart failure as primary cause of admission or significant heart failure symptoms that develop during the hospitalization when the initial reason for admission was not heart failure. * systolic dysfunction (lvef \< 40%) or heart failure symptoms in the setting of preserved systolic function (diastolic dysfunction). exclusion criteria: * this study has no exclusion criteria.

Keywords: registry optimize heart failure optimize-hf
pivotal assessment of the effects of bioactive on health and wellbeing. from human genome to food industry

Conditions: Metabolic Syndrome

Summary: this is a multi-centre, randomised, double-blind, placebo-controlled, parallel-arm dietary intervention study. in total, 800 men and women at risk for metabolic syndrome (ms) will be recruited. subjects will be eligible to the study if they present with two to four of the ms diagnostic criteria, at least one of them being: * fasting triglycerides ≥150 mg/dl but ≤400 mg/dl or * hdl-cholesterol ≤50 mg/ml in women, ≤ 40mg/ml in men (with fasting triglycerides ≥110 mg/dl). each of the four recruiting centres will recruit 200 volunteers. participants will be randomly assigned to one of four groups to receive either: * dairy bef + egg placebo + bakery placebo * egg bef + dairy placebo + bakery placebo * bakery bef + dairy placebo + egg placebo * dairy, egg and bakery placebo participants will be required to consume all three of the allocated products each day for 12 weeks. eligible volunteers will be included and randomly allocated to one of the four groups. at baseline, 6 weeks and 12 weeks after inclusion, each participant will visit the recruiting centre for clinical and biochemical investigations. at 3 weeks and 9 weeks participants will complete questionnaires relating to their satisfaction with the food products, compliance to consumption of the study food products, and any gastrointestinal side effects or health-related adverse events that have occurred in the previous 3 weeks. at each recruiting centre 40 participants will be required to take part in additional activities, these are: stool sample collection, adipose tissue aspiration, body composition analysis by dual energy x-ray absorptiometry (dexa) and assessment of physical activity.


Eligibility criteria:
inclusion criteria: * subjects presenting with two to four diagnostic criteria for metabolic syndrome, at least one of them being elevated fasting triglycerides or hdl-cholesterol ≤50 mg/ml in women, ≤ 40mg/ml in men (with fasting triglycerides ≥110 mg/dl). exclusion criteria: * subjects with five clinical criteria for metabolic syndrome * regular drug therapy with impact on serum lipids; * diabetes (fasting glucose \> 1.26 g/l, or anti-diabetic treatment); * celiac disease, lactose intolerance, allergy to milk or egg proteins; * antibiotic treatment within the last 3 months; * recent history of cancer or cancer treatment (less than 2 years); * active or recently diagnosed intestinal malabsorption; * diagnosis of organ failure * familial dyslipidemia (tg ≥ 4.5 mmol/l or 400 mg/dl); * illegal drug use or chronic alcoholism or smoking; * intensive physical exercise (≥ 5 hour/week); * consumption of nutritional supplements containing dha, bg or ac; * history of allergy or intolerance to any components used in bef; * women who are pregnant or lactating;

Keywords: bioactive enriched foods anthocyanins (ac) beta-glucans (bg) docosahexaenoic acid (dha)
comparative efficacy and safety of benzoyl peroxide used in combination with clindamycin vs. benzoyl peroxide used in combination with clindamycin and doxycycline in the treatment of moderate acne

Conditions: Acne

Summary: to compare the efficacy and safety of benzoyl peroxide used in combination with clindamycin vs. benzoyl peroxide used in combination with clindamycin and doxycycline in the treatment of moderate acne

to compare the efficacy and safety of benzoyl peroxide used in combination with clindamycin vs. benzoyl peroxide used in combination with clindamycin and doxycycline once daily in the treatment of moderate acne

Eligibility criteria:
inclusion criteria: * male or female subjects with acne vulgaris . able to understand the requirements of the study and sign informed consent/hipaa authorization forms. exclusion criteria: * known hypersensitivity to any of the components of the study drugs or used of prohibited medications or any medical condition that contraindicate the subject's participation in the clinical study

Keywords: acne
race, ethnicity, and diffuse parenchymal lung disease

Conditions: Idiopathic Pulmonary Fibrosis; Interstitial Lung Disease; Diffuse Parenchymal Lung Disease

Summary: the purpose of this study is to identify factors that contribute to higher mortality rates among blacks and hispanics with diffuse parenchymal lung disease.

it is well known that both socioeconomic and biological factors may contribute to race- and ethnicity-based health disparities. black and hispanic americans have worse access to healthcare services and tend to receive care from physicians who cannot themselves access the same services for their patients that physicians who care for white patients can. these factors may play important roles in the development and maintenance of health disparities. in addition, biological differences may contribute to disparities. we propose to identify factors that explain survival disparities in a group of lung diseases called diffuse parenchymal lung diseases (dplds), including a severe form of dpld called idiopathic pulmonary fibrosis (ipf). we will follow patients with dpld at our center and measure both social and biological factors to try to identify the factors that lead to survival disparities between races. results of this study will be used to design clinical trials aimed at reducing these disparities.

Eligibility criteria:
inclusion criteria: * diagnosis of ipf or other dpld according to ats criteria * signed informed consent exclusion criteria: * none

Keywords: idiopathic pulmonary fibrosis interstitial lung disease diffuse parenchymal lung disease health disparities
recovery group pilot

Conditions: Bipolar Disorder; Schizophrenia; Schizoaffective Disorder

Summary: the purpose of this study is to develop and evaluate a low-cost, joint consumer/counselor-led, health education and support intervention that will foster self-care and recovery among adults with serious mental illness. results from the study will indicate how well the workbook and the overall program were received by individuals with serious mental illness, and whether participating in the program appeared to improve recovery and functioning.

recent research suggests that many individuals with serious mental illnesses may recover from these conditions and become fully integrated into their communities. although improved medications may be most responsible for these developments, self-help groups, social support, and empowerment have been identified as important facilitators of the recovery process. recovery-oriented, consumer-led approaches are gaining in popularity, but few of these interventions have been evaluated scientifically. this pilot study proposes to develop and evaluate a recovery-oriented program that centers on the use of a self-help workbook. results from the study will indicate how well the workbook and the overall program were received by individuals with serious mental illness, and whether participating in the program appeared to improve recovery and functioning. objectives: 1. to develop group-facilitator materials to complement the self-help workbook. 2. to conduct a randomized trial of the intervention with kaiser permanente northwest (kpnw) members with bipolar disorder or schizophrenia/schizoaffective disorder, using a delayed control group design and 6- and 12-month post-intervention follow-up. 3. to assess participant attendance and satisfaction with the group sessions; 4. to assess whether participating in the group intervention was associated with improvements in short-term recovery and functioning.

Eligibility criteria:
inclusion criteria: * diagnosis of bipolar disorder or schizophrenia/schizoaffective disorder * current membership in kpnw * age 18 or over exclusion criteria: * having a guardian * psychotic symptoms that interfere with group interactions * dementia, mental retardation (other than mild) or other organic brain conditions that affect an individual's ability to participate in an interview, a group intervention, or complete questionnaires

Keywords: recovery serious mental illness bipolar disorder schizophrenia schizoaffective disorder
ancillary effects of dexmedetomidine sedation after cardiac surgery

Conditions: Heart Disease

Summary: ancillary effects of dexmedetomidine sedation after cardiac surgery

the investigator goal is to evaluate the effects of intraoperative and postoperative dexmedetomidine sedation (versus placebo after cardiac surgery.

Eligibility criteria:
inclusion criteria: 1. 18-85 years old; 2. scheduled for cardiac surgery with bypass (cabg, valve, or combined); 3. able to provide a written informed consent; 4. hemodynamically stable (heart rate\>= 55). exclusion criteria: 1. sick sinus syndrome or wolff-parkinson-white syndrome 2. atrio-ventricular block 3. hypersensitivity or known allergy to dexmedetomidine 4. hepatic disease, e.g. twice the normal level of liver enzymes 5. atrial fibrillation within 1 preoperative month; 6. permanent pacemaker; 7. use of amiodarone or dexmedetomidine within the last 30 days; 8. patients with an ejection fraction under 30% or who had severe heart failure 9. myocardial infarction in the previ¬ous 7 days; 10. body mass index =\< 40 (bmi= mass (kg) / height (m)2); 11. those taking clonidine within last 48 hours.
transthoracic ultrasonography findings and their relation to spirometric indices in patients with obstructive and restrictive respiratory diseases

Conditions: Lung Ultrasound; Spirometry; Respiratory Diseases; Diaphragm Ultrasound

Summary: evaluation of respiratory function is considered a crucial component in the assessment of patients with a wide range of respiratory diseases. spirometry is considered a common method of measuring pulmonary function. recently, transthoracic ultrasound yields important diagnostic information within minutes. respiratory muscle ultrasound is used to evaluate the anatomy and function of the respiratory system.


Eligibility criteria:
inclusion criteria: 1 -age \>18 years 2-patients diagnosed with copd or asthma. 3-patients diagnosed with ild or any other restrictive lung diseases. 4-normal people. exclusion criteria: 1. age \<18 years old. 2. critically ill patients in intensive care units. 3. patients with neurological diseases.