Kornimate/medical-research-clean huggingface dataset:
fabry disease screening in esrd patients in west of france

Conditions: ESRD

Summary: screening of fabry disease in end-stage renal disease (esrd) patients on dialysis or transplant in west of france.

detection of fabry disease is done by dried blood spot test, in dialyzed and transplanted men, who reached esrd for vascular or unknown disease and were not previously screened.

Eligibility criteria:
inclusion criteria: * men less than 70 years old * esrd treated by dialysis or kidney graft in one of the 4 following regions : bretagne, centre, pays de la loire and poitou-charentes * for unknown nephropathy or vascular nephropathy and/or diabetic nephropathy unproved by biopsy * agreeing freely to participate in the study exclusion criteria: * men less than 18 years old * persons subject to major legal protection (safeguarding justice, guardianship, trusteeship), persons deprived of liberty.

Keywords: esrd fabry disease
mypadmgt support of out-patients with peripheral arterial disease

Conditions: Peripheral Arterial Disease

Summary: the investigators have developed an online program to help people with peripheral arterial disease (pad) in their extremities to better self-manage their condition. some earlier testing has been done and the investigators now wish to try this system with participants who have this blood vessel disease as well as high blood pressure. investigators are hoping to help these participants to achieve healthier lifestyles and improve their quality of life through education, monitoring and continuing support. a similar online desk-top version with over 30 participants has been tested at st. michael's hospital in toronto. the investigators propose to test this newer mobile system with 210 outpatient participants from hamilton general hospital. data collected will be analyzed following the (12 months for each participant) study, along with data recorded during clinical visits at baseline and twelve months for each participant. the objective is to evaluate changes to participant health and determine whether the health self-management process has been successful in improving participant lifestyles and quality of life, when compared to usual care.


Eligibility criteria:
inclusion criteria: * out-patients with peripheral arterial disease (ankle brachial index \< 0.90) * attending the hamilton general hospital outpatient vascular clinic * may be living alone or with one or more caregivers * must have internet access. exclusion criteria: * age \< 18 years * not diagnosed with pad * unable to communicate in english * unwilling to participate * patients with dementia.
sofosbuvir containing regimens in treatment of covid 19 patients

Conditions: Covid19

Summary: efficacy and safety of sofosbuvir containing regimens in treatment of covid-19 egyptian patients,

the study aims to assess sofosbuvir containing regimens in treatment of covid-19 egyptian patients,

Eligibility criteria:
inclusion criteria: * covid 19 positive patients exclusion criteria: * covid-19 patients with critical manifestations. * sepsis. * acute respiratory distress syndrome (ards). * decompensated liver disease (child-pugh class b or c disease). * chronic renal impairment. * patients with blood diseases (severe anemia, thalassemia, itp, leukemia ....). * ischemic heart disease within the last 6 months. * chronic pulmonary disease. * malignancy. * pregnancy or breastfeeding. * hypersensitivity to sofosbuvir or ribavirin. * patients with organ transplant. * unwilling to participate in our study
using 360° videos in the treatment of anxiety disorders

Conditions: Social Anxiety Disorder; Agoraphobia

Summary: this study aims to test the feasibility and efficacy of an individualized exposure intervention using 360-degree videos for social anxiety and agoraphobia. a multiple single case design is followed with a pre-post-follow up assessment and multiple baselines. in addition, an experience sampling method is used to explore the role of dysfunctional beliefs and self-efficacy in the efficacy intervention.

there is growing evidence that supports the use of virtual reality (vr) to address anxiety disorders such as social anxiety and agoraphobia. the main advantage of vr is to expose participants to their fears in a controlled and safe environment. however, the access to vr remains costly for health professionals who need to pay licenses for the use of a limited number of environments. therefore, these standardized environments only address the symptoms of standard anxious patients. as a way to provide an accessible tool that can be tailored according to patients' specific difficulties, the proposed approach builds on 360-degree videos as an alternative to vr. the aim of the present study is to test the feasibility and efficacy of an individualized expo-sure intervention using 360-degree videos. in addition, the role of cognitive processes (i.e., dysfunctional beliefs and self-efficacy) in the exposure efficacy is examined. the intervention includes eleven sessions including five sessions of exposure in 360-degree videos de-signed especially for each patient difficulties. a multiple single-case design (n=5) is adopted with three types of evaluations: (1) traditional assessment scale of primary/secondary outcomes and aspects related to the therapy, (2) daily ambulatory assessment with a multiple baseline design, (3) experience sampling of cognitive processes about feared situations. each video will also be assessed by the participants after exposure sessions.

Eligibility criteria:
inclusion criteria: * primary diagnostic (dsm 5) of social anxiety or agoraphobia * high level of avoidance * french-speaking * having a mobile phone which met vr reading criteria exclusion criteria: * having a history of psychotic or bipolar disorder * having a history of severe brain trauma or epilepsy * having a history of respiratory disturbances * with a concurrent additional psychotherapy * with acute suicidal ideation * with a primary diagnosis of depression * with a non stabilized medication * auto medication with alcohol or other substances * having migraine or motion sickness

Keywords: 360-degree videos virtual reality exposure therapy anxiety disorders
insomnia in postmenopausal osteoporosis

Conditions: Osteoporosis

Summary: aim of the study was to determine the presence of sleep problems in postmenopausal osteoporosis patients and to examine the relationship between the severity of insomnia and mood and fatigue. pain, sleep problems, depression, anxiety, and fatigue were assessed using appropriate scales

the research was planned as a clinical cross-sectional study. two hundred women, aged between 50-75 years, who were diagnosed with postmenopausal osteoporosis and followed up in the outpatient clinics of beylikdüzü state hospital and istanbul physical medicine and rehabilitation training and research hospital between may 19, 2024, and june 19, 2024, were included. sociodemographic data such as gender, height, weight, body mass index, educational status, and occupation were recorded. the date of osteoporosis diagnosis, history of falls within the last 6 months, presence of fractures due to low-energy trauma, osteoporosis treatment, medications used, and comorbidities were questioned. the presence and location of pain were asked, and if pain was present, its intensity was determined using the visual analog scale. calcium and vitamin d levels from the last 3 months were recorded. the patient's sleep problems were assessed using the insomnia severity index. subsequently, the patient's current depression and anxiety-related symptoms were measured using the hospital anxiety and depression scale (hads), and the fatigue level was assessed with the fatigue severity scale (fss).

Eligibility criteria:
inclusion criteria: * women diagnosed with postmenopausal osteoporosis. * patients who agreed to participate in the study. * age range between 50-75 years. exclusion criteria: * presence of fibromyalgia. * chronic fatigue syndrome. * chronic decompensated cardiac, renal, or hepatic failure. * known psychiatric disorders. * rheumatological diseases. * presence of other known neurological diseases. * use of medications that enhance physical performance or alleviate fatigue.
elimination of hcv through linkage and in prison treatment of incarcerated populations (eclipse)

Conditions: HCV Infection

Summary: hepatitis c (hcv) is a chronic infection with significant morbidity and mortality. the development of directly acting antivirals (daa) has dramatically improved the cure rate of hcv treatment. people who experience incarceration are disproportionately infected and often involved in ongoing transmission of disease. however, despite availability of effective treatment, people who experience incarceration are often unable to access this curative therapy, and are often not readily engaged in medical care upon release. this perpetuates transmission and progression of disease in an incredibly high risk, marginalized population. therefore, in order to effectively eliminate hcv, it is imperative that the epidemic of hcv in prisons is addressed, and that models of care are established for treatment of hcv in incarcerated individuals, both during and after incarceration. as such, the investigators propose a comprehensive model of care to engage incarcerated individuals in treatment of hcv upon release from prison. this care is provided in conjunction with collocated services to prevent hcv reinfection, including opioid agonist therapy. this pilot trial will demonstrate whether a comprehensive model of care can effectively cure hcv in recently incarcerated individuals, while simultaneously treating opioid use disorder and preventing hcv reinfection.


Eligibility criteria:
inclusion criteria: 1. age greater than or equal to 18 years old 2. able and willing to sign informed consent 3. for the community linkage arm: chronically infected with hcv, defined as any individual with documentation of positive hcv antibody and positive hcv rna test (hcv rna of 2,000 iu/ml or greater). 4. for the community linkage arm: ineligible for treatment through the prison/jail without a known sentence longer than 9 months, as of consent date 5. for the in-prison arm: achievement of svr through the previous standard of care treatment through the doc exclusion criteria: 1. decompensated cirrhosis (child-pugh b or c) 2. pregnant or breastfeeding women 3. for community linkage arm: prior treatment with a direct acting antiviral regimen 4. for community linkage arm: any co-medications that are contraindicated or not recommended for concomitant use with glecaprevir-pibrentasvir 5. poor venous access not allowing screening laboratory collection 6. have any condition that the investigator considers a contraindication to study participation

Keywords: hcv infection incarcerated individuals
better in better out cystectomy.

Conditions: Bladder Cancer

Summary: the current gold standard for non-metastatic muscle-invasive bladder cancer or treatment-refractory high-risk non-muscle-invasive bladder cancer is radical cystectomy (rc). this procedure is associated with high rates of perioperative complications (30-65%) and mortality (1.5-10%). patients who require radical cystectomy often present with multiple co-morbidities, a certain degree of frailty, functional deficits, and a high level of past or current tobacco use. according to the "better in, better out" principle, it is likely that by improving the physical, nutritional and psychological status, a reduction in morbidity and mortality will be observed. the literature suggests that multimodal prehabilitation may reduce complications and improve functional recovery after major cancer surgery. therefore, the prehabilitation programme used in this study includes exercise training, dietary advice, psychological support and smoking cessation advice. prehabilitation has been offered to a selection of patients with increased risk for postoperative complications since 01/05/2023. at zol genk, patients receive preparation for rc in one of three ways, depending on a balancing exercise that considers the patient's complexity and frailty, functionality, mobility and other factors. patient preference and place of residence are also taken into account in determining the most appropriate preparation pathway. 1. the patient is solely encouraged to increase his fitness level by means of independent aerobic exercise. 2. the patient receives a prescription for primary care physiotherapy in his own area. 3. the patient undergoes our full internal prehabilitation program. the primary objective of this study is to compare these three different groups in terms of mortality, icu length of stay, length of hospital stay, complication rate, type of complications and readmission rate. finally, patient adherence will be examined.


Eligibility criteria:
inclusion criteria: * histologically confirmed primary bladder cancer (cta-4n0-3m0) who underwent rarc. exclusion criteria: * patients who needed a semi-urgent cystectomy. * patients with severe cognitive or psychiatric impairment. * patients with a contraindication to perform physical exercise training or a cardiopulmonary exercise test (cpet). * metastatic or non-primary disease.
effectiveness of chiropractic cervical manipulation in lateral epicondylitis

Conditions: Lateral Epicondylitis

Summary: i̇t is aimed to examine the effect of chiropractic cervical manipulation on pain, functionality and grip strength in patients with lateral epicondylitis and whether it is preferable to placebo.

lateral epicondylitis (le) is known as chronic symptomatic degeneration of the forearm common extensor tendon attachment at the humeral ectochondyle. it is one of the most common overuse syndromes today and is characterized by loss of function and pain due to an inflammatory reaction that occurs during stretching of the condyle. the main goals of the treatments are to relieve pain, reduce overload on the arm and elbow joints, accelerate the healing process and enable the patient to regain functionality in daily life activities at the optimum time. many treatment methods have been applied for this purpose, and the number of studies on the effectiveness of manual applications is increasing. among manual applications, chiropractic applications have recently attracted attention.

Eligibility criteria:
inclusion criteria: * (1) age between 20-50 years, * (2) dominant right extremity and ipsilateral lateral epicondylitis, * (3) full range of motion in the cervical region, exclusion criteria: * (1) spinal root compression (radiculopathy), * (2) neurologic symptoms such as loss of strength in the lower extremities, upper extremities and face, numbness, involuntary movements, abnormal gait pattern, dizziness, nausea/vomiting of unknown cause, swallowing and speech difficulties, * (3) pregnancy, * (4) presence of active malignancies, * (5) positive pre- manipulative vertebrobasilar insufficiency test, * (6) use of anticoagulant and antiaggregant drugs, * (7) history of previous cervical surgery or whiplash, * (8) acute inflammatory disease, * (9) positive results of the test performed before manipulation in the cervical spine (foraminal compression test, * (10) any deformity in the new york posture analysis, * (11) unwillingness to participates

Keywords: lateral epicondylitis chiropractic cervical manipulation
comparative efficacy of lidocaine spray versus vaginal misoprostol in iud insertion

Conditions: Contraception

Summary: the aim of the present study is to compare the safety and efficacy of lidocaine spray versus misoprostol in reducing pain during iud insertion in adolescents and nulliparous women


Eligibility criteria:
inclusion criteria: * adolescent and young nulliparous women requesting iud insertion exclusion criteria: * multiparous women, contraindications to iud insertion or to study drugs
video laryngoscopy in pre-hospital critical care

Conditions: Airway Morbidity; Airway Disease; Respiratory Insufficiency; Respiratory Failure

Summary: difficult conditions and critically ill and injured patients may complicate endotracheal intubation in the pre-hospital setting. the incidence of complications increase when two or more endotracheal intubation attempts are needed. the aim of this study is to estimate the incidence of difficult pre-hospital endotracheal intubation after the introduction of the mcgrath mac video laryngoscope as the primary airway device for pre-hospital endotracheal intubation. hypothesis: • in our pre-hospital critical care teams, staffed with experienced anaesthesiologists, the rate of difficult pheti (defined as more than one intubation attempt needed to secure a patent airway) is lower than 10 %, when using the mcgrath mac vl as primary choice in pre-hospital intubations.


Eligibility criteria:
inclusion criteria: * patients where the anaesthesiologists on the participating pre-hospital critical care teams attempt prehospital endotracheal intubation. exclusion criteria: * patients\< 15 years of age

Keywords: video laryngoscope pre-hospital endotracheal intubation difficult endotracheal intubation pre hospital critical care mcgrath mac airway device
the effects of weight loss on tinnitus symptoms

Conditions: Subjective Tinnitus; Obesity

Summary: subjective tinnitus is the perception of irregular sound at different frequencies. although the underlying cause of tinnitus is unclear, increased body weight is known to increase tinnitus symptoms. this study aimed to determine the effects of dietary and physical activity interventions on tinnitus symptoms. sixty-three obese subjects with tinnitus aged 20 to 65 years were divided into diet + physical 8 activity (p.a.), diet, p.a., and control groups. dietary and anthropometric records, tinnitus handicap 9inventory (thi), beck depression inventory (bdi), short-form health survey (sf-36), and visual analogue scale (vas) of all individuals were compared at the baseline and at the end of the study.

although the underlying cause of tinnitus is unclear, increased body weight is known to increase tinnitus symptoms. the present study aimed to determine the effects of dietary and physical activity interventions on tinnitus symptoms. sixty-three obese subjects with tinnitus aged 20 to 65 years were divided into diet + physical activity (p.a.) (n = 15), diet (n = 16), p.a. (n = 15), and control (n = 17) groups. dietary records, anthropometric measurements, tinnitus handicap inventory (thi), beck depression inventory (bdi), short-form health survey (sf-36), and visual analogue scale (vas) of all individuals were recorded and compared at the baseline and at study completion.

Eligibility criteria:
inclusion criteria: * obese exclusion criteria: * diagnosed with tinnitus

Keywords: tinnitus diet physical activity
empagliflozin and sympathetic nerve traffic

Conditions: Type 2 Diabetes Mellitus

Summary: in this study the effects of the inhibition of the sodium-glucose linked transporter 2 in the kidney with empagliflozin compared to hydrochlorothiazide on blood pressure and on central sympathic nervous activity will be examined.

the drug empagliflozin is a selective oral inhibitor of the sodium-glucose co-transporter 2 (sglt-2) in the kidney.on the market empagliflozin is approved for the treatment of type 2 diabetes. the mechanism of action can be described as follows: sglt-2 is responsible for 90% of the reabsorption of glucose in the kidney. if this transport system is inhibited the secretion of glucose via the urine is increased. therefore the blood glucose concentration will be lowered. it has been noted that the sglt-2 drugs are lowering the blood pressure as well, but the specific characteristics of the durg leading to this effect have not been examined in adequate clinical trial up to now. to evaluate the central sympathic nervous activity a microneurography will be performed in this study; this examination will provide information if empagliflozin dose decrease the sympathic nervous activity. if this is the case new effects of empagliflozin have to be discussed, otherwise it can be assumed that the blood pressure decrease is a result of an increase of urine volume. in this case the sympathic activity should be increased. this study will be performed in parallel groups who will receive a double-blind, randomised treatment, either empagliflozin or hydrochlorothiazide. the hypothesis that empagliflozin - in contrast to hydrochlorthiazide - does not increase the sympathic nervous activity in obese, hypertensive subjects with type 2 diabetes treated with metformin will be tested.

Eligibility criteria:
inclusion criteria: * women and men \>= 50 and \<= 80 years of age * type 2 diabetes mellitus for \>=2 years * only metformin monotherapy is allowed; metformin dose must have been stable for \>=12 weeks exclusion criteria: * previous empagliflozin treatment within the last 3 months * heart failure nyha ii - iv * subjects who have received any investigational medicinal product or have used any investigational medical device within 30 days prior to the screening visit, or who are actively participating in any investigational medicinal product or medical device trial, or who are scheduled for any such trial during the course of the trial.
the impact of climate environment in different latitudes on the occurrence of picc complications

Conditions: Cancer; Thrombus; Phlebitis; Infections

Summary: in this study, eligible subjects were randomly assigned to the experimental or control group through randomization (1:1). under the guidance of electrocardiographic doppler ultrasound guided puncture and catheterization (edug) technology, the tunnel puncture method was compared with the conventional puncture method. the two groups of patients were observed and evaluated intraoperative and postoperative 7 ± 3 days, 30 ± 7 days, 60 ± 10 days, and 90 ± 10 days 120 ± 10 days (if any) and the occurrence of complications during extubation or unplanned extubation at the end of treatment, comparing cases in the north and south, as well as complications related to different catheterization methods


Eligibility criteria:
inclusion criteria: * patients aged ≥ 18 years old; * patients who follow medical advice and require picc catheterization; * patients who have not participated in other clinical studies; * patients who voluntarily participate in this clinical study and can cooperate with clinical follow-up; * there are no serious cardiovascular diseases, such as atrial fibrillation, pulmonary heart disease, and other p-wave abnormalities before catheterization, as well as severe heart conduction block exclusion criteria: * known allergies to catheter materials; * there is a history of infection, injury, and radiation therapy at the puncture site; * the puncture site has a history of venous thrombosis or surgery; * severe abnormal coagulation function; * superior vena cava compression syndrome; * surgical side limbs of breast cancer patients undergoing radical mastectomy or axillary lymph node dissection; * heart pacemaker and arteriovenous fistula on the same side of the limb; * patients or patients' family members refuse to sign the informed consent form.