Kornimate/medical-research-clean huggingface dataset:
specialist dietetic intervention in malnourished patients with fibrotic ild: a randomised controlled pilot trial

Conditions: Interstitial Lung Disease

Summary: malnutrition occurs when the body receives too few nutrients, resulting in health problems such as weight loss. the consequences of malnutrition are worrying as they include lung failure, infection, and pressure ulcers. interstitial lung disease (ild) is a term used for a group of diseases which can cause scarring of the lungs. having ild can cause malnutrition due to the lungs working hard and burning off energy. additionally, medications called anti-fibrotic agents are used to slow disease progression. however, side effects include poor appetite, diarrhoea, nausea, vomiting and weight loss which can result in malnutrition. malnutrition occurs in ild in approximately half of patients. this is important because the main signs of malnutrition such as weight loss and a low body mass index (bmi), which takes into consideration your weight against your height, are linked with worse outcomes in ild. malnutrition in ild can also reduce eligibility for lung transplant and can impact tolerability of anti-fibrotic agents. research into treatment of malnutrition in ild is limited. dietitians play a key role in diagnosis and treatment of malnutrition. this is because dietary counselling by a dietitian has been shown to increase quality of life and intake of energy in other chronic diseases. there are currently no studies documenting the benefits of dietetic intervention in patients with ild. we propose to undertake the first feasibility study in this area. a feasibility study is a first step trial which investigates whether a study can \& should be done. the main aims of this study are: 1. how easy it is to recruit ild patients to see a dietitian 2. whether patients will attend dietetic appointments 3. whether food/nutrient intake is increased following dietetic intervention 4. how acceptable is dietetic intervention to ild patients as well as these main aims, this study will also provide initial information about whether dietetic intervention stabilises weight, bmi \& quality of life.


Eligibility criteria:
inclusion criteria: * bmi ≤ 20kg/m2, or if aged \>75, bmi ≤ 21 (righini et al., 2013) * over the past 12 months, unintentional weight loss ≥ 5% of body weight, regardless of baseline bmi or weight loss \>2 kg if bmi is normal. exclusion criteria: * co-morbidities currently requiring a specialised diet (including enteral feeding) * end of life care (estimated less than 6 weeks left to live) * expected introduction of anti-fibrotic or immunosuppressive treatment or introduction/increase corticosteroid dose during trial period * pregnancy * unable to give consent
clinical study on lower limb robot for lower limb dysfunction after stroke

Conditions: Stroke

Summary: the goal of this clinical trial is to learn about effect of lower robot in stroke population. the main question\[s\] it aims to answer are: the efficacy of lower limb robot assisted training in improving walking ability, lower limb function, cognition, and quality of life in stroke patients.the robot group of patients received lower limb robot assisted training combined with routine rehabilitation treatment. the control group only received routine rehabilitation treatment.compare two groups to explore the therapeutic effect of lower limb robots on lower limb dysfunction after stroke.


Eligibility criteria:
inclusion criteria: * in line with the diagnostic criteria for stroke in the diagnostic criteria for various cerebrovascular diseases issued by the chinese medical association in 2019. * first stroke or no residual dysfunction after previous stroke. * participants have stable vital signs, clear consciousness, and no aphasia. * the onset time of stroke is between 2 weeks and 6 months after onset. * age\>18 years old. * presence of hemiplegic motor dysfunction. * ability to walk with the help of a single person. * sign an informed consent form with the participants or family member before treatment. exclusion criteria: * participants have serious musculoskeletal or other mental nervous system disease. * participants have contraindications to cardiovascular exercise. * moderate to severe contracture of the patient's lower limbs (modified ashworth scale, mas\>2 for ankle, knee, or hip joints). * presence of progressive or secondary brain injury leading to unstable condition. * unilateral neglect or diseases that affect vision. * participants have lower limb vein thrombosis. * participants present with lower limb non healing ulcers and osteoporosis.

Keywords: stroke robotics
prophylactic methylprednisolone for renal protection in cardiac surgeries with cardiopulmonary bypass

Conditions: Cardiopulmonary Bypass; AKI - Acute Kidney Injury

Summary: the aim of the planned study is to assess the prophylactic effect of intraoperative administration of a single dose of methylprednisolone 2 (mg/kg) in decreasing the incidence of postoperative acute kidney injury after cardiac surgeries with cardiopulmonary bypass.

patients undergoing any type of elective cardiac surgical procedure requiring cpb will be randomly assigned into one of the following groups 1. placebo group / control group will receives normal saline as a placebo after the induction of anesthesia and before initiating cpb. 2. methylprednisolone group / interventional group receives a single intra-venous dose of methylprednisolone (2 mg/kg) after the induction of anesthesia, and before the initiation of cpb. measurements: primary outcome: incidence of occurrence of postoperative acute kidney injury for 7 days according to the rifle criteria. secondary outcome: 1. incidence of postoperatively hyperglycemia (blood glucose level of ≥ 140 mg/dl) for 7 days, 2. duration of icu stay, 3. length of hospital stay (los), 4. incidence of wound infection, 5. incidence of peptic ulcer, 6. incidence of sepsis.

Eligibility criteria:
inclusion criteria: 1. age 18-65 years. 2. sex: both sexes. 3. patients with american society of anesthesiologists (asa) score iii-iv. 4. patients scheduled for any kind of elective cardiac surgical procedure requiring cardiopulmonary bypass (e.g., coronary artery bypass grafting (cabg), valve repair/replacement, or combined procedures ( exclusion criteria: 1. declining to give written informed consent. 2. history of allergy to the medications used in the study. 3. diabetic patients with hba1c \>6.5 4. moderate to severe hepatic diseases (child b-c) 5. hepatic dysfunction: inr \> 1.5, serum albumin \< 2.9 g%. 6. renal dysfunction (serum creatinine level \>1.3 mg/dl, or gfr \< 80 ml/min./1.73/m2 7. patients with a recent history of aki. 8. patients undergoing urgent cardiac surgery. 9. patients undergoing cardiac surgeries with deep hypothermic total circulatory arrest. 10. planned off-pump procedure. 11. any cardiac surgery exceeds 45 minutes on aortic cross clamp. 12. patients requiring high doses of inotropes and/or vasopressors intraoperative or postoperative (high-dose dopamine is defined as peak doses of \>15 μg/kg/min, high-dose norepinephrine is defined as peak dose \>0.1 μg/kg/min, high-dose epinephrine is defined as peak dose \>0.1 μg/kg/min) 13. delayed extubation for more than 6 hours postoperative. 14. patients developed postoperative complications as (septic shock and bleeding)

Keywords: aki cpb
bssplus versus lactated ringer's for phacoemulsification

Conditions: Cataract

Summary: two intraocular irrigating solutions (bssplus versus lactated ringer's) are compared in this prospective, randomized, masked trial to investigate for differences in preservation of corneal integrity after phacoemulsification cataract surgery.


Eligibility criteria:
inclusion criteria: * patients with senile cataract * visual acuity between 20/400 and 20/40 exclusion criteria: * presence of corneal opacity * presence of corneal disease * traumatic, toxic, hereditary (congenital)and complicated cataracts(uveitis) * anterior chamber cells or flare detected before surgery * previous ocular surgery * any condition which may affect documentation or follow-up

Keywords: cataract phacoemulsification irrigation solution endothelial cell density corneal thickness
dual-task assessment and rehabilitation for individuals with residual symptoms after mtbi

Conditions: Brain Injury Traumatic Mild; Concussion, Brain

Summary: this research aims to develop an intervention that combines mtbi-specific motor and cognitive challenges into a progressive and challenging rehabilitation program. we plan to develop and refine a combined motor and cognitive intervention using healthy athletic young adults (n=12) and people with a positive history of non-resolving mtbi (n=12). we will conduct limited feasibility testing by conducting 6 week training sessions with each subject group. we also plan to identify best measures for determining readiness for duty or full function by incorporating and testing 3 dual-task assessment measures using state-of-the-art wearable sensors to quantify movement.


Eligibility criteria:
inclusion criteria-healthy control: * adults aged 18-34 years of age. * strong history of athletic participation including high school and collegiate varsity and/or club sports * current sport or recreational sport participation at least 3 days per week * willingness to participate in 3 times a week 60 minute exercise program conducted at courage kenny research center (ckrc). exclusion criteria-healthy control: * history of concussion. * history of orthopedic or neurologic diagnosis (stroke, multiple sclerosis, parkinson's disease, etc.) interfering with subject's ability to exercise * unwilling to exercise. * at risk for cardiopulmonary disease as defined by the american college of sports medicine. * active medical contraindications by self-report after explanation of dual-task exercise program. * active chemical dependency or major psychiatric disorders (ie., schizophrenia, major psychosis) by self-report. inclusion criteria-subjects with mtbi residual symptoms: * adults aged 18-50 years of age. * self-report of some consistent exercise or activity a minimum of 2-3 days per week. * 3 weeks to 24 months post most recent concussion seeking treatment at courage kenny rehabilitation institute (ckri) clinics * willingness to participate in 3 times a week 60 minute exercise program conducted at ckrc. exclusion criteria- subjects with mtbi residual symptoms: * history of orthopedic or neurologic diagnosis (stroke, multiple sclerosis, parkinson disease, etc.) interfering with subject's ability to exercise * unwilling to exercise. * at risk for cardiopulmonary disease as defined by the american college of sports medicine. * active medical contraindications by self-report after explanation of dual-task exercise program, * active chemical dependency or major psychiatric disorders (ie., schizophrenia, major psychosis).
myofascial points treatment with focused extracorporeal shock waves (esw)

Conditions: Plantar Fasciitis; Myofascial Trigger Point Pain; Foot Injury

Summary: plantar fasciitis (pf) is a common cause of heel pain. among the several conservative treatment options, extracorporeal shock wave therapy (eswt) is considered the standard treatment. recent studies suggest that pf may be sustained by a myofascial impairment proximal to the pain area with a biomechanical disequilibrium of the entire lower limb and pelvis. therefore, by combining the concepts of fascial manipulation and eswt, the purpose of this open label randomized controlled clinical trial is to evaluate the effectiveness of the eswt on myofascial trigger points of lower limb in a sample of subjects with pf. patients with pf were randomly assigned to an experimental treatment group (eg), treated with focused eswt on myofascial points, and a control group (cg), treated with the focused eswt traditional approach on the medial calcaneal tubercle. outcome measures included the foot and ankle outcome score (faos) and the italian foot functional index (17-iffi). the assessment was made before the first session(baseline-t1), immediately before the second session (t2), immediately before the third session (t3), at 1month (t4) and 4 months' follow-up (t5). thirty patients who satisfied inclusion and exclusion criteria were enrolled.


Eligibility criteria:
inclusion criteria: * ≥ 18 years of age, * the presence of heel pain ≥ 3 months duration unresponsive to first-choice conservative treatments (non-steroidal anti-inflammatory and/or other analgesic drugs, exercise program, insoles), * specialist diagnosis of plantar fasciitis confirmed with clinical examination, * pain intensity ≥ 5 at the visual analog scale (vas) exclusion criteria: * previous ankle/foot fracture or surgery, * previous ankle/foot infections, * neurological deficits of the lower limbs, * diagnosis or suspect of fibromyalgia, * local steroid injection within the previous 3 months, * diabetes mellitus, * vascular diseases
safety of nxy-059 for the treatment of patients who have suffered from a stroke

Conditions: Intracerebral Hemorrhage

Summary: this study will determine if nxy-059 is safe in patients with an acute stroke caused by bleeding in the central nervous system. the primary objective was to assess the safety and tolerability of nxy-059 compared to placebo.


Eligibility criteria:
inclusion criteria: * males and females * intracerebral hemorrhage as the cause of stroke symptoms * onset of symptoms within 6 hours * full functional independence prior to the present stroke exclusion criteria: * unconsciousness * subjects who are unlikely to complete the infusion of investigational product and/or are unlikely to undergo active medical management during that period due to a severe clinical condition. * severe illness with life expectancy less than 6 months. * known severe kidney disorder. * current known alcohol or illicit drug abuse or dependence. * pregnant or breast-feeding. * treatment with acetazolamide and methotrexate is not permitted during the infusion * participation in a previous clinical study within 7 days. * meets all other exclusion criteria

Keywords: stroke cerebral vascular accident cva hemorrhage intracerebral hemorrhage (ich) brain attack cataplexy
smart gaming in obesity

Conditions: Obesity

Summary: obesity (body mass index ≥ 30 kg/m2) is associated with diminished executive functioning. the primary objective of this randomized, controlled trial is to evaluate the efficacy of a behavioral weight loss program coupled with enhanced executive functioning training via serious gaming on weight loss and weight loss maintenance in adults with obesity and executive functioning deficits compared to adults undergoing standard behavioral treatment alone (n = 200). serious gaming interventions that target the specific cognitive functions needed for weight-loss maintenance may improve long-term weight-loss success.

this randomized, controlled study will evaluate the efficacy of a behavioral weight loss program coupled with enhanced executive functioning training via serious gaming (bwl+gaming) on weight loss and maintenance in adults with obesity and executive functioning deficits compared to standard behavioral treatment alone (bwl) at two urban philadelphia university-based clinics (pcom \[philadelphia college of osteopathic medicine\] and temple university). participants will be recruited from the community. all participants (n = 200) will complete 12 weeks of behavioral weight loss treatment. intervention participants will also complete 30-minutes (5 days per week for 8 weeks) of a serious gaming program, which will feature online games developed specifically to enhance executive functions. the primary outcomes are weight change and weight change maintenance, which will be measured at 12 and 52 weeks, respectively. neuropsychological testing will evaluate the proposed mechanism of action, changes in executive functioning, before and after treatment (12 and 52 weeks).

Eligibility criteria:
inclusion criteria: * obesity * executive functioning deficits * internet access exclusion criteria: * under 18 years of age * over 65 years of age * taking weight loss medication * pregnant
metabolomics of thyroid hormones

Conditions: Central Hypothyroidism; Hypothyroidism; Hyperthyroidism

Summary: the aim of this study is to develop a metabolome signature of thyroid hormone status. the metabolome signature could be useful in diagnosis and treatment of thyroid dysfunction diseases, especially in cases where tsh cannot be reliably used.

primary hypothyroidism is a frequent endocrine disorder, where the thyroid gland does not produce sufficient amounts of thyroid hormones. the substitution therapy is guided by measurement of the pituitary gland hormone thyrotropin (tsh). patients with central hypothyroidism in whom pituitary insufficiency leads to hypothyroidism, tsh cannot be used to guide therapy. so far there are no reliable methods for therapy control in patients with central hypothyroidism. the measurement of small endogenous metabolites might give investigators a metabolomics profile. this could help to discriminate between euthyroid, hypothyroid and hyperthyroid state and therefore could be used for diagnosis and therapy control of thyroid dysfunction diseases.

Eligibility criteria:
inclusion criteria: all participants: * age 18 to 80 years * bmi 19 to 35 kg/m2 * informed consent as documented by signature a) patients with primary hyperthyroidism tsh \ 25 pm or ft3 \> 8 pm b) patients with primary hypothyroidism, currently not sufficiently substituted tsh \> 8 milli-international unit (miu)/l or ft4 \< 10 pm c) patients with diagnosis of primary hypothyroidism, sufficiently substituted documented diagnosis of primary hypothyroidism substitution with l-thyroxin tsh in target range between 0.5 and 2.5 miu/l d) patients with secondary hypothyroidism pituitary disease with documented secondary hypothyroidism exclusion criteria: * diabetes mellitus (hba1c \>6.5%) * severe concomitant diseases: chronic heart failure, liver cirrhosis, kidney failure, active cancer * abuse of alcohol or illicit drugs * women who are pregnant or breast feeding * inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant * previous enrolment into the current study

Keywords: hypothyroidism metabolomics thyroid hormones hyperthyroidism
cosmetic outcome study of lid laceration repair with suture versus tissue adhesive

Conditions: Eyelid Laceration

Summary: this project is a randomized, controlled trial investigating wound cosmetic appearance after repair of traumatic lid lacerations with three different approaches to skin closure: absorbable sutures, non-absorbable sutures, and tissue adhesive. photographs will be taken at two intervals after repair and later blindly assessed using standard cosmetic assessment scales. the investigators hypothesize that cosmetic wound outcome will be equivalent in across all three treatment arms.

this project is a randomized, controlled trial investigating the cosmetic appearance after repair of traumatic lid lacerations with three different approaches to skin closure: absorbable sutures (surgical gut suture), non-absorbable sutures (polypropylene suture), and tissue adhesive (octyl-2-cyanoacrylate). the population will include patients presenting to memorial hermann hospital requiring repair of traumatic lid lacerations. the study will include partial thickness, full-thickness, and margin-involving lacerations where first standard layered tarsal and marginal suture repair will be performed if necessary, and then the patient will be randomized to superficial skin closure with either polypropylene suture closure, surgical gut suture closure, or tissue adhesive closure. subjects will be followed in an outpatient setting at 1 week and 1 month post-repair at which time standardized photographs will be taken and later assessed using two standardized appearance assessment tools: visual analogue scale (vas) and hollander wound evaluation score (hwes).

Eligibility criteria:
inclusion criteria: * 18 years of age or older. * any laceration caused by trauma and involving the skin of the upper and/or lower eyelid. * must be able to understand and sign an informed consent when applicable and health insurance portability and accountability act(hipaa) form that has been approved by an institutional review board (irb) or follow standard informed consent procedure of the irb exclusion criteria: * eyelid lacerations that include avulsion or missing eyelid tissue * patients with known hypersensitivity to octyl-2-cyanoacrylate or previous poor reaction to octyl-2-cyanoacrylate * eyelid lacerations resulting in necrosis or ischemia of tissue prior to repair * patients who demonstrate intoxication or mental status changes that would make them unfit to provide informed consent for repair

Keywords: trauma eyelid laceration tissue adhesive suture cosmetic octyl-2-cyanoacrylate
effect of exercise training in alzheimer's patients

Conditions: Alzheimer Disease

Summary: the objective of this study was to examine the effects of exercise training on physical function and biochemical markers in elderly alzheimer's disease patients.

alzheimer's disease is a neurodegenerative disease characterized by progressive and irreversible degeneration of nerve cells. the loss of these cells leads to the continuous decline in muscle function with alterations in biochemical and haematological parameters. the objective of this study was to examine the effects of exercise training on physical function and biochemical markers in elderly alzheimer's disease patients.

Eligibility criteria:
inclusion criteria: * subjects with official diagnosis of alzheimer's disease; * subjects with mmse higher than12. exclusion criteria: • subjects with mmse below 12 (indicating severe dementia and impairment).
impact of postural balance changes on low back pain during pregnancy

Conditions: Pregnancy; Low Back Pain

Summary: this study will be conducted to determine the impact of postural balance changes on low back pain during pregnancy

back pain is a major problem in the general population, and it is thought to be even more common in pregnant women who have given birth. it has been hypothesized that this type of pregnancy-related low back pain (lbp) may be related to changes in lumbar posture, perhaps accompanied by stretching abdominal muscles or specific hormonal effects of pregnancy .during pregnancy, many hormonal, anatomical, and musculoskeletal changes occur. these changes alter the postural balance and increase the risk of falls. falls during pregnancy can cause maternal and foetal injuries. moreover, the incidence of falls during pregnancy is higher compared to non-pregnant women of the same age. the risk of falls increases with the gestational age, and most falls are experienced in the third trimester. so, this study will be designed to conduct new information about the relation between postural changes and low back pain during pregnancy

Eligibility criteria:
inclusion criteria: * pregnant women in 2nd and 3rd trimesters. * pregnant women suffering from low back pain * their age will range from 20-35 years. * their body mass index (bmi) will be less than 35 kg/m2 exclusion criteria: * non pregnant women. * women who have any history of diseases associated with balance disorder * women who have any neurological disorders. * women who have lower limbs deformities * women who have optical problems and disorders * women who have cerebrovascular disease

Keywords: postural balance low back pain pregnacy