Kornimate/medical-research-clean huggingface dataset:
minocycline for helicobacter pylori rescue treatment

Conditions: Helicobacter Pylori Infection

Summary: current guidelines have recommended classical bismuth-containing quadruple therapy including proton-pump inhibitor, bismuth, tetracycline, metronidazole as the empirical rescue therapy. however, tetracycline is clinically unavailable in china and the high frequency of adverse events of bismuth quadruple therapy often result in poor compliance, which limited the applicability of this recommendation. we previously showed that the efficacy of bismuth-containing quadruple therapy with minocycline and metronidazole was not inferior to classical bismuth quadruple therapy for refractory h. pylori infection, though also accompanied with high occurrence of adverse events.this study aimed to evaluate the efficacy and tolerability of four different regimens with minocycline and metronidazole compared to classical bismuth quadruple therapy for h. pylori rescue treatment in a real-world setting.


Eligibility criteria:
inclusion criteria: * confirmed h. pylori infection and with previous treatment failure exclusion criteria: * subjects naive to h. pylori treatment, * history of gastrectomy * pregnant or lactating women * severe systemic diseases or malignancy * administration of antibiotics, bismuth, antisecretory drugs, or chinese herb medicine in the preceding 12 weeks

Keywords: helicobacter pylori rescue therapy minocycline
urinary excretion of enteroviruses from children with a presumed enteroviral infection

Conditions: Enterovirus Infections

Summary: enteroviruses can infect most human organ systems, especially the heart, nervous system and pancreas. whether enteroviruses can also affect the kidneys is not known yet. therefore we will analyze urine of children with a suspected enteroviral infection for enteroviruses and signs of kidney infection.

enteroviruses have been shown to cause mesangioproliferation and glomerulonephritis in mice (especially coxsackievirus b4). in some cases, large amounts of iga are deposited in the mesangium, resembling human iga-nephropathy. in humans, case reports indicate the propensity of certain enteroviruses to cause kidney infections. our project aims to analyze urine of children with suspected enteroviral infections (e.g. meningitis, myocarditis, sepsis of the newborn etc.) to identify cases suspicious of concomitant enteroviral kidney affection. to achieve this aim, enterovirus-pcrs will be performed and microhematuria searched for.

Eligibility criteria:
inclusion criteria: * children, suspected of suffering from an enteroviral infection

Keywords: enterovirus meningitis sepsis myocarditis kidney urine glomerulonephritis
cauterization of the anterior ethmoidal artery by transconjunctival approach

Conditions: Epistaxis, Anterior Ethmoid Artery

Summary: the incidence of epistaxis varies from 7 to 14% in the general population and represents 30 per 100,000 emergency room admissions in adults. most nasal bleeding is self-limiting without the need for specific medical treatment. cauterization under local anesthesia and control of medical comorbidities (arterial hypertension and hemostasis disorders) are effective in most cases. in case of failure of cauterization or in case of more posterior epistaxis, an antero-posterior packing can be put in place for 48 hours. in case of failure or recurrence of packing removal, endoscopic sphenopalatine artery (spa) ligation or embolization is proposed. in case of persistent epistaxis despite hemostasis of the psa, ligation of the anterior ethmoidal artery (aea) is recommended. this artery cannot be embolized because of the risk to the ophthalmic artery. the ligation of the aea is most often performed via the external paracanthal approach. it can also be performed by endonasal endoscopic approach but involves the performance of an anterior ethmoidectomy, a long surgery with a significant risk of complications. its identification by the endonasal route is complicated in the event of abundant bleeding. moreover, its endoscopic cauterization is difficult if the artery is not procidente. the transconjunctival approach avoids a visible scar and the complications of an ethmoidectomy.

the objective of the study was to compare the efficacy of transconjunctival and external cauterization of the anterior ethmoidal artery in patients with refractory epistaxis

Eligibility criteria:
inclusion criteria: * male or female (age ≥18 years) * persistent epistaxis after meching * having required transconjunctival anterior ethmoidal artery cauterization surgery * subject operated at the university hospitals of strasbourg between 01/01/2015 and 01/05/2023 * subject not objecting to the reuse of his/her data for scientific research purposes. exclusion criteria: - subject who has expressed opposition to the reuse of his/her data for scientific research purposes.

Keywords: epistaxis anterior ethmoid artery arterial hypertension hemostasis disorders endoscopic sphenopalatine artery endonasal endoscopic anterior ethmoidectomy
rapid opiate detoxification and naltrexone induction using buprenorphine - 2

Conditions: Opioid-Related Disorders

Summary: the purpose of this study is to develop a clinical protocol to detoxify patients from opiates to naltrexone using buprenorphine and to develop pilot data for a grant application for a controlled study of the efficacy of the new clinical protocol for outpatients.


Eligibility criteria:
inclusion criteria: males/females, ages 21-50. opiate dependence according to dsm-iv criteria. self-reported use within the last 30 days. agreeable to conditions of study and signed informed consent. exclusion criteria: psychiatric disorder that requires medication therapy. history of seizures. pregnant and/or nursing women. dependent on etoh or benzodiazepines or other sedative-hypnotics. acute hepatitis. other medical conditions that deem participation to be unsafe.

Keywords: opioid-related disorders
study to examine effect of recombinant luteinizing hormone (r-lh) and recombinant human chorionic gonadotropin (r-hcg) for ovarian stimulation in assisted reproduction techniques (art)

Conditions: Controlled Ovarian Stimulation; Infertility

Summary: the study is a prospective, randomised, controlled, and non-blinded multi-center pilot study to evaluate endocrine efficacy of recombinant luteinizing hormone versus recombinant human chorionic gonadotropin administered during controlled ovarian stimulation for ivf/icsi in normogonadotrophic women.


Eligibility criteria:
inclusion criteria: * women who plan to undergo ivf or icsi treatment * woman's age \> 18 years but ≤ 35 years * regular menstrual cycle (25-34 days) * bmi 18 to 30 inclusive * signed patient information and informed consent forms exclusion criteria: * pcos * more than 2 prior ivf/icsi attempts * diabetes mellitus, epilepsy, lever-, kidney-, heart- and metabolism disorders, according to the investigator's assessment.

Keywords: cos art infertility
diet management on hepatic encephalopathy of patients with variceal bleeding after intrahepatic portosystemic shunt creation

Conditions: Hepatic Encephalopathy

Summary: hepatic encephalopathy is a severe complication of transjugular intrahepatic portosystemic shunt (tips) treatment in patients with cirrhosis and variceal bleeding. this study is specially designed to explore whether diet management strategy could decrease incidence of encephalopathy after tips treatment.

hepatic encephalopathy (he) is a severe complication of tips treatment in patients with cirrhosis and variceal bleeding. the overall incidence of post-tips encephalopathy ranges between 10% and 50%, and even the percentage of the new or worsened he was evaluated up to 13-36%. no approach or medication was evidenced for prophylaxis of post-tips encephalopathy, including lactulose and rifaximin. diet management has been used as an important part of the prophylaxis and treatment strategy for patients with metabolic diseases like diabetes and nephritis, which has drawn increasing interest of clinicians. nevertheless, there is still no standard consensus or even recommendation for patients after tips procedure for now, which worsened malnutrition and affected survival. thus, this study is specially designed to explore whether diet management strategy, drawn up from the nutritional management consensus of hepatic encephalopathy (ishen consensus), could decrease incidence of encephalopathy after tips treatment of the patient with cirrhosis and variceal bleeding.

Eligibility criteria:
inclusion criteria: * patients with decompensated liver cirrhosis regardless of the etiology * acute variceal bleeding or with history of variceal bleeding evidenced by endoscopy * an age between 18 and 75 years old exclusion criteria: * a total bilirubin level more than 3mg/dl (51.3mmol/l) * a creatinine level greater than 3 mg/dl(265umol/l) * severe dysfunction of heart and respiratory system * pregnancy * uncontrolled neoplasm * active systemic infection * history of any kind of encephalopathy, mental disease, alcohol dependence, or any other status that influence brain function * diabetes or any other metabolic diseases

Keywords: hepatic encephalopathy diet management transjugular intrahepatic portosystemic shunt
role of dcr3 in t cell activation in sle and ra

Conditions: SLE; Rheumatoid Arthritis

Summary: decoy receptor 3 (dcr3), a new member of tumor necrosis factor receptor (tnfr) superfamily, is a decoy receptor for fasl and could inhibit fasl-induced apoptosis, has recently been shown to induce costimulation of t cells. systemic lupus erythematosus (sle) is an autoimmune disease with pathogenic autoantibodies and immune complexes results from abnormal immune responses including t and b lymphocyte hyperactivity, and formation of pathogenic subsets of autoantibodies. rhematoid arthritis (ra) is a multi-systemic autoimmune disease characterized by persistent inflammatory synovitis. activated t lymphocytes infiltration to synovium is strongly correlated with the symptoms. dcr3 mrna is expressed in peripheral-blood t cells and is up-regulated after antigenic stimulation. the dcr3 gene has been demonstrated to be overexpressed in patients with sclerosis or sle; however, role of dcr3 in sle and ra as well as the effects of dcr3 on t cell immune response is still not clear. this study is to investigate role of dcr3-induced t cell activation in sle and ra. the genetic polymorphisms of dcr3 in association with sle and ra will be studied to elucidate the genetic factors associated with development of sle and ra. for further explore the possible molecular mechanisms of elevated dcr3 in association with sle, we attempt to study whether dcr3 could induce t cell activation via costimualtion and/or inhibit the activation induced cell death (aicd) of activated t cells in sle and ra. this study will provide a new direction of therapy in reverse t cell hyper-reactivity in sle and ra.

specific aim 1. study dcr3-induced t cell activation in sle and ra. a. patients and controls patients with sle and ra in department of internal medicine, national taiwan university hospital will be studied. all patient meet the criteria of the american college of rheumatologists for diagnosis of sle and ra. as controls, 20 healthy age- and gender-matched volunteers will be used. all the studies including samples involving human is in accordance with institutional guidelines. b. detection of serum dcr3 protein in sle and ra patients c. t cell proliferation assay specific aim 2. study effects of dcr3 on activation-induced cell death (aicd) in sle and ra in order to understand whether dcr3 could reduce the aicd in activated t cells in sle and ra patients, the t cells from these patients will be assayed their aicd in the presence and absence of soluble dcr3-fc. specific aim 3. to investigate the association of clinical manifestation of sle and ra with genetic polymorphism on dcr3 genes. a. the gene sequencing and single nucleotide polymorphism (snp) analysis of dcr3 genes. b. the association of clinical manifestation of sle and ra with genetic polymorphism on dcr3 genes.

Eligibility criteria:
inclusion criteria: * sle, ra exclusion criteria: * nil
effect of new topical preparation for treatment of acne vulgaris

Conditions: Acne Vulgaris

Summary: the investigators propose a randomized, double-blind control trial study to evaluate the efficacy and safety of the optimized topical combination me of the investigated drugs in the treatment of acne vulgaris containing dap-flu in comparison with standard therapy of adapalene at mansoura university dermatology and andrology outpatient clinic.


Eligibility criteria:
inclusion criteria: 1. male and females age 12 or older 2. clinical diagnosis of mild to moderate facial acne vulgaris defined as: 1. ≥ 5 inflammatory lesions, and; 2. ≥ 10 non-inflammatory lesions, and; 3. iga 2-3 3. willing to refrain from using any treatments, other than the investigational product, for acne present on the face. this includes the use of antibiotics for the treatment of acne. 4. willing and able to provide informed consent and to comply with the study protocol. exclusion criteria: 1. women were excluded if they were pregnant, nursing, or planning a pregnancy as were men with facial hair that would interfere with the assessments. 2. continuous or planned use of tanning booths or excessive sun exposure, in the opinion of the investigator. 3. treatment with systemic corticosteroids within 28 days prior to baseline. 4. two or more active nodular lesions. 5. use of androgen receptor blockers (such as spironolactone or flutamide) in the 7 days prior to randomization.
use of fosfomycin in the treatment of bacterial infections

Conditions: Analyze the Medical Records of Patients Admitted At ASST Lecco from 01/04/2020 to 31/12/2023 Treated with Fosfomycin IV

Summary: fosfomycin is an antibiotic discovered since 1969. disodium fosfomycin, for intravenous use (c3h5na2o4p) is a bactericidal antibiotic, available in italy since 2019 (aifa approval). it works by blocking the enzyme udp-n-acetylglucosamine enolpyruvil transferase, inhibiting the synthesis of peptidoglycan. it binds poorly to plasma proteins and is distributed very well in various tissues such as: eyes, bones, skin and subcutaneous tissue, muscles, lungs, prostate, bile and inflamed meninges. it also has a strong anti-biofilm activity. fosfomycin is active against gram-positive bacteria (staphylococci, streptococci, enterococci, including mrsa and vre) and gram-negative bacteria (enterobacterales, haemophilus influenzae, proteus mirabilis, pseudomonas aeruginosa, including mdr strains) and against difficult-to-treat bacteria such as serratia marcescens, stenotrophomonas maltophilia, bacteroides spp and intracellular bacteria such as chlamydia and mycoplasma. it has no activity against acinetobacter spp, peptococcus spp. and peptostreptococcus spp, burkholderia cepacia, and mycobacterium tuberculosis. iv fosfomycin is approved for the treatment of osteomyelitis, complicated urinary tract infections, pneumonia including hospital-acquired and ventilator-associated pneumonia, complicated skin and soft tissue infections, bacterial meningitis, and complicated bacteremia. in this retrospective study, the investigators want to analyze the medical records of all patients admitted to the asst of lecco from 01/04/2020 to 31/12/2023 treated with fosfomycin iv in order to evaluate different clinical outcomes given the recent introduction at asst lecco


Eligibility criteria:
inclusion criteria: * age \> 18 years; * patients hospitalized at a. manzoni lecco between april 2020 and december 2023; * patients treated with iv fosfomycin as monotherapy or in combination with other antibiotics for at least 72 hours. exclusion criteria: * patients who received fosfomycin iv for less than 72h for any cause (death, adverse events, clinical decision).
the effect of dietary intervention on endothelial glycocalyx in psoriasis

Conditions: Psoriasis

Summary: the food supplement endocalyx is considered to support the endothelial glycocalyx integrity by supplying sulfated polysaccharides, anti-oxidant enzymes and additional substrates for glycocalyx synthesis. the investigators will study the effect of endocalyx on endothelial, vascular and left ventricular myocardial function in patients with psoriatic disease.

sixty patients with psoriatic disease, who are referred to the outpatient psoriasis clinic of the attikon university hospital, will be randomized to receive food supplement endocalyx (4 capsules per day) (n=30) or placebo (n=30) for 4 consecutive months.

Eligibility criteria:
inclusion criteria: * caucasian patients with psoriatic disease (plaque-type psoriasis or psoriatic arthritis) * body mass index ≥18.5 kg/m2 * if female, patients must be non-pregnant and non-breastfeeding exclusion criteria: * history of acute coronary syndrome. coronary artery disease will be excluded by a clinical history, examination and electrocardiogram. * moderate or severe valve disease * primary cardiomyopathies * chronic obstructive pulmonary disease * asthma * chronic kidney disease * liver failure * malignancies

Keywords: psoriasis endothelial glycocalyx arterial stiffness coronary microcirculation left ventricular myocardial deformation
efficacy and safety of rhegf in diabetic foot ulcer patients with uncontrolled diabetic mellitus

Conditions: Diabetic Foot Ulcer Patients With Uncontrolled Diabetes Mellitus

Summary: the purpose of this clinical trial is to evaluate the safety and efficacy of rhegf (recombinant human epidermal growth factor) in diabetic foot ulcer patients with uncontrolled diabetes mellitus.


Eligibility criteria:
post-approval study of the tecnis® toric extended cylinder range intraocular lens (iol)

Conditions: Cataract; Astigmatism

Summary: this study is a prospective, multicenter, bilateral, non-randomized, open-label, clinical study conducted at up to 20 sites in the usa. subjects were to be bilaterally implanted with one eye having an extended cylinder (high cylinder) toric iol (model zct450, zct525 or zct600) and the fellow eye having a high cylinder toric iol (model zct450, zct525 or zct600) or a lower cylinder toric iol (zct300 or zct400). this study evaluates the outcomes for subjects implanted with at least one higher cylinder toric iol.

the purpose of this study is to evaluate the performance of the higher cylinder (zct450,zct525 and zct600) toric iols. some subjects had the higher cylinder toric iols in both eyes with other subjects having a higher cylinder toric iol in one eye and the lower cylinder toric iol in the other eye. per the statistical plan, data for the zct450/525/600 toric iols were to be pooled together and reported as one group. the primary endpoint is the rate of severe visual distortions reported by subject at 6 months via questionnaire. the analysis population for this endpoint will be bilaterally implanted subjects with a high cylinder iol (zct450/525/600) in the primary eye and a high cylinder iol (zct450/525/600) or a low cylinder iol (zct300/400) in the fellow eye. there were no formal secondary endpoints. data from a few other endpoints (rate of iol repositioning due to iol misalignment and percent change in cylinder) have been reported. for these endpoints the analysis population contains all subjects implanted with a zct450/525/600 in at least one eye. adverse events were reported by subject for all subjects with a high cylinder iol (zct450/525/600) in at least one eye.

Eligibility criteria:
inclusion criteria: * minimum 22 years of age * bilateral cataracts * preoperative keratometric cylinder of at least 2.00 d in both eyes with at least one eye having approximately 3.00 d to 4.75 d of corneal astigmatism. * ability to understand, read and write english in order to consent to study participation and complete a study questionnaire * signed informed consent and hipaa authorization exclusion criteria: * irregular corneal astigmatism * any corneal pathology/abnormality other than regular corneal astigmatism * previous corneal surgery or recent ocular trauma or intraocular surgery that is not resolved/stable or may affect visual outcomes * any pupil abnormalities * subjects with conditions associated with increased risk of zonular rupture, including capsular or zonular abnormalities that may lead to iol decentration * known ocular disease or pathology that may affect visual acuity or that may require surgical intervention during the course of the study * concurrent participation or participation during 30 days prior to preoperative visit in any other clinical study * planned monovision correction * patient is pregnant, plans to become pregnant or is lactating
prospective evaluation of the role of mri in the perioperative management of pancreas adenocarcinomas

Conditions: Pancreas Adenocarcinomas

Summary: the precision of mri has improved over the past few years, in particular for the hepatobiliary and pancreatic pathologies. the role of mri in the management of operated pancreas tumors remains nevertheless unclear and few studies have compared mri to the actual gold standard (ct). compared to ct, mri is not only a morphologic imaging technique but also a functional imaging technique. mri could therefore evaluate in a non-ionizing and dynamic way several important pre- and postoperative aspects after pancreaticoduodenectomy (pd). this study on the perioperative role of mri includes 3 parts: first, ct is known to minimize the real size of the pancreatic tumors and to underestimate the vascular invasion correlated to resectability. the preoperative determination of the resection surgical margins could be improved thanks to the high-contrast resolution of mri. moreover, pd is a complex surgery encompassing a fragile anastomosis between the pancreatic parenchyma and the digestive tract. the permeability of the pancreatic anastomosis after pd remains presently unknown and has not been correlated to the clinical state of the patient. mri associated with secretin injection allows evaluating this permeability, which cannot be done by ct due to the absence of functional evaluation. finally, present radiological follow-up after pd for tumors of the pancreatic head is performed with ct. the mri performance has not been demonstrated yet in the context of follow-up. this imaging modality nevertheless offers unique specificities that are very interesting and that could be helpful for the diagnosis of recurrence.


Eligibility criteria:
inclusion criteria: * patients over 18 years old * indication for a pd for a resectable adenocarcinoma of the pancreatic head. exclusion criteria: * chronic pancreatitis * absence of discernment * patients not speaking french * preoperative radio/chemotherapy * patients with claustrophobia * patients with metallic implants.