Kornimate/medical-research-clean huggingface dataset:
the effect of acupressure on polyneuropathy-related pain and sleep quality

Conditions: Type 2 Diabetes

Summary: this study aimed to determine the effect of acupressure on polyneuropathy-related pain and sleep quality in patients with type 2 diabetes. a randomized controlled experimental design was employed in the study. the study sample consisted of 86 patients with type 2 diabetes (44 in the acupressure group and 42 in the control group) who met the inclusion criteria and agreed to participate. participants were randomly assigned to either the experimental or control group. the experimental group received six sessions of acupressure over six consecutive days, while the control group received no intervention. data were collected using a personal information form, the pain quality assessment scale (pqas), and the pittsburgh sleep quality index (psqi). statistical analyses were conducted using spss for windows 22. acupressure was found to reduce polyneuropathy-related pain and enhance sleep quality in patients with type 2 diabetes. therefore, acupressure may be considered an alternative nursing intervention for individuals with type 2 diabetes.


Eligibility criteria:
inclusion criteria: * were between the ages of 18-65 years old * resided in the city center * had no additional diseases that could cause sensory neuropathy, such as peripheral arterial disease, peripheric vein disease, nervous system diseases, benign or malign tumor, chemotherapy history, carpal tunnel syndrome, and arthritis. * had no clotting or bleeding disorders * were not undergoing dialysis treatment during the study period * had no ulcers, physical deformities or foot calluses * had no history of analgesic medication, except for medication used for dpn * had no physical diseases, cognitive deficiencies or psychiatric disease diagnosis that would prevent understanding of the questions on the scales used for data collection.

Keywords: acupressure, diabetes, nursing, polyneuropathy, sleep quality
icotinib with concurrent radiotherapy versus chemotherapy with concurrent radiotherapy in non-small cell lung cancer

Conditions: Non-small Cell Lung Cancer

Summary: this randomised, multi-center, controlled trial is designed to assess the efficacy and safety of icotinib with concurrent radiotherapy versus chemotherapy with concurrent radiotherapy in non-small cell lung cancer

this randomised, multi-center, controlled trial is designed to assess the efficacy and safety of icotinib with concurrent radiotherapy versus etoposide/cisplatin with concurrent radiotherapy in stage iii non-small cell lung cancer with egfr 19/21 mutation, the primary endpoint is progression-free survival

Eligibility criteria:
inclusion criteria: * unresectable stage iiia / iiib non-small cell lung cancer with egfr 19/21 mutation * no previous systemic anticancer therapy * measurable lesion according to recist with at least one measurable lesion not previously irradiated, unless disease progression has been documented at that site * ecog performance status of 0 to 1 exclusion criteria: * prior treatment with anti-egfr (the epidermal growth factor receptor) monoclonal antibody or small molecular compounds therapy such as gefitinib, erlotinib or cetuximab * evidence of clinically active interstitial lung diseases (patients with chronic, stable, radiographic changes who are asymptomatic need not be excluded) * known severe hypersensitivity to icotinib or any of the excipients of this product
a multicenter study to evaluate the efficacy of a 91-day extended cycle oral contraceptive for menstrually-related migraine headaches

Conditions: Migraine

Summary: this study is being conducted to evaluate the efficacy of a 91-day extended cycle oral contraceptive compared to placebo for decreasing the frequency and severity of menstrually-related migraine headaches.


Eligibility criteria:
inclusion criteria: * premenopausal, non-pregnant, non-lactating * history of migraine headaches without aura for at least 6 months * history of migraine headaches associated with menstruation * others as directed by fda-approved protocol exclusion criteria: * history of migraine headaches with aura or focal neurological symptoms * any contraindication to the use of oral contraceptives * others as dictated by fda-approved protocol

Keywords: migraine headache menstrual oral contraceptive menstrually-related migraine headache
a randomized controlled trial of sp-01 (granisetron transdermal delivery system) in chemotherapy-induced nausea and vomiting

Conditions: Chemotherapy-induced Nausea and Vomiting

Summary: the purpose of this study is to assess the efficacy and safety of sp-01 in chemotherapy-induced nausea and vomiting (cinv) associated with the administration of moderately or highly emetogenic (me or he) multi-day chemotherapy，which will provide scientific and reliable clinical data in the drug registration in china.


Eligibility criteria:
inclusion criteria: * male or female aged ≥ 18years * histologically and/or cytologically confirmed cancer * the physical status score ecog ≤ 2 * life expectancy of ≥3 months * will receive multi-day me/he chemotherapy (≥2 days) with the emetogenic potential of level 3-5 * in accordance with the indication of chemotherapy and basic requirements; * peripheral haematology: hb ≥ 9.0 g/dl, absolute neutrophil count ≥ 1.5×10e9/l, platelet count ≥ 80×10e9/l * blood biochemistry: total bilirubin \< 1.25×uln, alt and ast ≤ 2.5×uln; if liver metastasis, alt and ast \< 5×uln, creatinine ≤ 1×uln, basic normal serum electrolyte (na, ka, cl, ca) * other important organs function normally * subjects voluntarily participate and signed the informed consent form
correlation of antibody response to covid-19 vaccination in pregnant woman and transplacental passage into cord blood.

Conditions: Covid-19

Summary: the goal of this study is to study the correlation of maternal and cord blood level of anti sar-cov.

the goal of this study is to study the correlation of maternal and cord blood level of anti sar-cov. sample size is 40 thai patients at labor room vachira phuket hospital in october - november 2023, who have at least one covid-19 vaccination before or when pregnant. the secondary outcome is to study time effect after covid-19 vaccination and effect of vaccine type on antibody level.

Eligibility criteria:
inclusion criteria: * thai term pregnant women * 18-45 year old * at least 1 covid vaccination received * admission at vachira phuket hospital labor room exclusion criteria: * do not want to participate * unstable or emergency condition

Keywords: anti sars-cov pregnancy cordblood vaccine
the importance of exercise to prevent injuries in athletes

Conditions: Injury;Sports

Summary: introduction: running is one of the most accessible and practiced sports in the world since the 21st century. unfortunately, the incidence of injuries in the population that practices it is high regardless of experience, although the risk of injury increases in amateur runners. one of the main keys to reduce the incidence of running related injuries may be to improve the ability to reduce the load or impact. for this, there are different strategies such as a gradual increase in the load to run, and exercise within which is muscle strengthening and balance training or proprioception. objective: to verify the effectiveness of a program of proprioceptive exercises based on the static and dynamic balance for the reduction of lower limb injuries in amateur runners during the competition season.

methodology: 66 amateur runners, after simple size calculation, will be randomized into two groups. experimental group will carry out the proprioceptive exercise program during 8 weeks at the begining of the season and control group will continue with their usual training routine. the main variable running related injury will be collected weekly during the follow-up. results: when all the data needed for the study has been collected, researchers gathers results and exports them for statistical interpretation.

Eligibility criteria:
inclusion criteria: * weekly training of at least 15 kilometers. * at least practice running 6 months for 1-3 times a week. exclusion criteria: * to have some type of lower limb or lower back injury at present or in the last 6 months. * having undergone surgery for any back or lower limb injury. * pregnant. * neural dysfunction / disability.

Keywords: proprioception running prevention injuries
accuracy of different scoring systems for predicting successful induction of labor

Conditions: Induction of Labor Affected Fetus / Newborn

Summary: induction of labour (iol) nowadays is a common procedure in obstetric practice. presently, iol is done for 20% of pregnancies for various maternal and fetal indications and nearly 20% of labour inductions end up in caesarean deliveries. the success of iol mainly depends upon "favourability" of the cervix which is usually assessed by manual examination and scored as bishop score. however, this method is limited by subjectivity and reproducibility and though done in all the patients prior to iol, several studies have demonstrated poor correlation between bishop score and outcome of iol


Eligibility criteria:
inclusion criteria: 1. singleton pregnancy. 2. pregnant ≥ 37 weeks gestation. 3. fetus with longitudinal lie and vertex presentation. 4. intact membranes. 5. no vaginal bleeding. exclusion criteria: 1. patients with previous cesarean delivery. 2. previous uterine surgery. 3. antepartum hemorrhage. 4. cephalopelvic disproportion. 5. category ii or iii non-stress test. 6. malpresentation. 7. intrauterine fetal death. 8. fetal growth restriction. 9. fetuses with major congenital malformations
detection of endoscopic resection scars and delineation of recurrence is trainable

Conditions: Colorectal Polyp; Colorectal Cancer

Summary: colorectal cancer is prevented by colonoscopy and polypectomy. failure to recognize the endoscopic resection scar after endoscopic mucosal resection (emr) risks unrecognized recurrent or residual adenoma (rra), which may propagate into post-colonoscopy colorectal cancer. expert series suggest scar recognition and interrogation is well performed with a high negative predictive value of endoscopic imaging vs histopathology. in this study the authors will investigate the performance of endoscopic imaging in detecting rra at an endoscopic resection scar amongst general endoscopist and the impact of a learning intervention on recognition of rra. after consent is given, the participant will open the online survey and fill this in. first the participant will be asked to create a pseudonym (name+year of birth) and fill in their demographical information (grade, years in current role, colonoscopy experience, experience of colonic tissue resection, country of employment the first 15 pictures will be shown prior to a learning intervention. for each picture the same questions will be asked: * is this an endoscopic resection scar? * based on this image does the scar demonstrate evidence of residual or recurrent adenoma (rra)? * what is your level of confidence? * if the scar shows rra, how would you treat it? (skip if you feel no rra). * if the scar does not show rra do you feel there is another diagnosis? after the first 15 pictures a video-based learning tool will be shown on detection of rra. after the learning tool 15 different pictures will be shown, the same questions will be asked. all responses will be collected by the investigators. statistical analysis will be performed using visual studio code (microsoft, redmond, usa) images will be selected from the 'australian colonic lsl endoscopic resection study' (ace) database, which is an international multicentre registry of images and videos for retrospective analysis of colonic lesions. images, videos, procedural information, and histopathological data are stored on a secure online web portal after written informed consent of every participating patient.


Eligibility criteria:
inclusion criteria: * endoscopists of any experience level exclusion criteria: * non consenting adults

Keywords: endoscopy advanced imaging post-colonoscopy colorectal cancer colorectal polypectomy
nutritional intake and bone health in celiac disease

Conditions: Celiac Disease

Summary: celiac disease leads to malnutrition and secondary conditions including osteoporosis. the dietary habits of adults with untreated, undiagnosed celiac disease has not yet been observed, but presents a critical piece in understanding the effects of the disease on bone health. objective was to evaluate differences in nutritional intake of calcium, vitamin d, and phosphorus; serologic indices of these nutrients; and bone health among adults with and without celiac disease. cross-sectional data from what we eat in america (wweia) and the national health and nutrition examination survey (nhanes) 2009-14 was analyzed.

celiac disease leads to malnutrition and secondary conditions including osteoporosis. the dietary habits of adults with untreated, undiagnosed celiac disease has not yet been observed, but presents a critical piece in understanding the effects of the disease on bone health. objective was to evaluate differences in nutritional intake of calcium, vitamin d, and phosphorus; serologic indices of these nutrients; and bone health among adults with and without celiac disease. cross-sectional data from what we eat in america (wweia) and the national health and nutrition examination survey (nhanes) 2009-14 was analyzed, including self-reported dietary and supplement intake from one day of 24-hour recalls, serologic indicators, and dual x-ray absorptiometry (dxa) scans were analyzed in adults (n=49) testing positive for celiac disease to the tissue transglutaminase endomysial antibody assay (ttg-ema). statistical analysis included multiple linear regression modelling controlled for age, sex, race/ethnicity, energy intake, and poverty income ratio.

Eligibility criteria:
inclusion criteria: adults aged 18+ years with a complete 24-hour recall in wweia and a completed celiac disease serologic test. two groups were used in the analysis. the control group consisted of a normal adult population without celiac disease, as indicated by a negative serologic test for celiac disease and no self-reported celiac disease. the serologically positive group were considered to have undiagnosed, untreated celiac disease based on a positive serologic test for celiac disease (ema+), no self-reported celiac disease, and no adherence to a gluten-free diet. nhanes employs two steps of serologic tests for selected participants to screen for celiac disease antibodies that develop as a t-cell-mediated response to gluten. exclusion criteria: * adults were excluded if they were pregnant or breastfeeding at the time of the study, or if they reported any history of celiac disease.
systemic consolidation therapy after primary chemoradiation therapy for locally advanced cervical cancer

Conditions: Cervical Cancer

Summary: the purpose of this study is to determine the therapeutic efficacy and complications of systemic consolidation therapy with paclitaxel plus carboplatin following primary chemoradiation for locally advanced cervical cancer.

systemic consolidation therapy with paclitaxel plus carboplatin (3 cycles per 3 weeks) following primary chemoradiation (3 cycles per 3 weeks) for locally advanced cervical cancer will elevate the therapeutic efficacy by removing the microscopic metastatic lesions which could not be identified by naked eye and diagnostic imaging tests.

Eligibility criteria:
inclusion criteria: * patients who underwent three cycles of concurrent chemoradiation therapy with paclitaxel and carboplatin for non-small cell type cervical cancer stage ib2, bulky size (\>4cm) iia,iib-iva * above 20 years * gog performance status 0-2 * informed consent * platelet\>100k, hb\> 10.0 g/dl, anc\>1500/mm3, cr \<1.25\*upper normal limit, bilirubin\<1.5mg/dl, ast \& alt\<\*3 upper normal limit * expected life \> 6 months exclusion criteria: * peripheral neurotoxicity \> nci ctcae grade 2 * sever infection * previous history with chemotherapy or radiation therapy * pleural effusion, pericardial effusion, and ascites which could cause dyspnea \> nci grade 2 * paraaortic lymph node metastasis * allergy with platinum * previous history of atrial or ventricular arrhythmia or congestive heart failure * uncontrolled infection, diabetes mellitus, hypertension, ischemic heart disease, myocardiac infarct within 6 months * severe disease such as acute or chronic renal failure and acute cerebral infarct, cerebral hemorrhage, recurrent hepatitis, liver cirrhosis, unknown fever above 39 degrees centigrade
pharmacokinetics study of donepezil hcl in subjects receiving haemodialysis.

Conditions: End-Stage Renal Disease

Summary: the purpose of this study is to investigate the pharmacokinetics of donepezil hcl 3 mg in subjects with end-state renal disease who were receiving haemodialysis.

this is a randomised, single-center, open-label, single-dose, two-period crossover pharmacokinetics study of donepezil hcl tablets 3 mg in subjects receiving haemodialysis. subjects will be or will not be receiving haemodialysis. after intervals of over 15 days, the subjects will be receiving the other treatment.

Eligibility criteria:
inclusion criteria: subjects with end-stage renal disease who were receiving haemodialysis. subject who are able and willing to give written informed consent. exclusion criteria: subjects with known hypersensitivity to drugs or foods. subjects with a corrected qt interval greater than 450 msec at screening period.

Keywords: end-stage renal disease hemodialysis donepezil hydrochloride pharmacokinetics cross-over study
effect of probiotics in childhood abdominal pain

Conditions: Abdominal Pain

Summary: the purpose of this study is to assess the effect of probiotics in childhood recurrent abdominal pain. patients will be randomly assigned to receive l. reuteri or placebo for 4 weeks with a follow up phase of additional 4 weeks.

prospective randomized double-blind placebo-controlled trial.

Eligibility criteria:
inclusion criteria: * healthy children exclusion criteria: * any chronic or organic illness

Keywords: childhood abdominal pain probiotics
stronger: muscle strengthening for menopause

Conditions: Resistance Training

Summary: menopause is a period of time with increased risk for muscle and bone loss. very few people strength train regularly at least 2 times per week, and commonly reported barriers include inadequate time and resources, worries of safety, inadequate knowledge base of what moves to do and how to do them. menopause-aged women may report unique barriers - or perceived facilitators - to strength training. this pilot study will develop and test the feasibility and acceptability of an at-home, band-based, expert-supported strength training intervention.

women are at particular risk for low muscle mass as they age, because menopause causes a dramatic reduction in circulating estrogen, which accelerates muscle decline. preserving muscle is one of the single most important factors to maintaining lifelong independence, with bone, metabolic, cardiovascular, and cognitive health benefits. the most critical behavior for growing and preserving muscle is resistance training, and conservative estimates indicate 4 in 5 us adults do not engage in any resistance training. commonly cited barriers for women include gender-based stigmas, discouragement, negative comments, poor knowledge of how to do resistance training, poor gym accessibility, and difficulty balancing work and family life. finally, many menopause practitioners note that with bodyweight as a large concern, many women decrease calorie intake and increase cardiovascular (not resistance) training, further compounding muscle loss. this proposed intervention study aims to develop and pilot a muscle health building intervention with and for menopausal women. broadly, the investigators will identify the adherence, feasibility, acceptability, and preliminary changes of a resistance training intervention for menopausal women. the investigators will pilot the 3-month "stronger" intervention, utilizing a protocol co-designed from focus groups. we will recruit women with menopause and randomize them into one of 2 groups: 1) single-session strength training (stronger); or 2) "stronger snacks," the same exercises as the single-session training but broken into single-set snack sizes that are performed throughout the week. the investigators hypothesize that the strength snacks will have the highest adherence and be the most behaviorally accessible and acceptable, but post-study interviews will also help us identify motivational differences.

Eligibility criteria:
inclusion criteria: * one year of no periods or categorized as menopause * female at birth * english speaking exclusion criteria: * unable to perform strength training movements * currently performing regular strength training activities or exercise
microparticles in scuba divers with decompression sickness

Conditions: Decompression Sickness; Dysbarism

Summary: the investigators hypothesize that membrane microparticles (mps) are liberated into the blood stream in response to decompression stress and that certain mps characteristics initiate inflammatory responses that contribute to the clinical syndrome the investigators call decompression sickness. the research goal is to evaluate the number, type and time-course for elevations in mps in sport scuba divers who present for treatment of decompression sickness. blood samples are to be taken from consenting patients before and after they undergo treatment for decompression sickness and at a follow-up clinic visit from 1 to 3 weeks later (three samples total).

microparticles (mps) are small membrane bound vesicles shed from the surface of a variety of cells by what appear to be well regulated processes. they are elevated in many physiological and disease states and in some instances have been associated with organ injury. shear stress - as can be caused by intravascular bubbles - is one of the stimuli known to cause cells to release microparticles. most sport scuba dives have been shown to generate intravascular bubbles - even safe dives well within limits established by the us navy and sports authorities. the investigators have reported elevations in several sub-types of mps in a group of individuals undergoing a well monitored series of open-water scuba dives. there is no information of the occurrence of mps in injured divers. the investigators have published results using a murine model which demonstrated that mice subjected to varying decompression stresses exhibit progressive elevations in circulating mps derived from leukocytes, erythrocytes, platelets and endothelial cells. using novel interventions the investigators demonstrated that mps cause intravascular neutrophil activation and inflammatory perivascular injuries. therefore, there is pathophysiological information to suggest that one or more element of mps (number and/or pro-inflammatory subtype) may be proximal elements that precipitate the clinical syndrome the investigators call decompression sickness.

Eligibility criteria:
inclusion criteria: * patients who are given the diagnosis of decompression sickness will be offered entry into this study exclusion criteria: * inability to provide informed consent

Keywords: decompression intravascular bubbles neutrophil activation