Kornimate/medical-research-clean huggingface dataset:
fractional co2 laser therapy versus 4% topical lidocaine gel for dyspareunia in breast cancer survivors

Conditions: Dyspareunia

Summary: this trial seeks to determine if therapy with a co2 laser to the vagina is more effective than lidocaine to the opening of the vagina before intercourse to reduce painful intercourse in women who are breast cancer survivors. this study will also be looking at whether or not the co2 laser improves pelvic floor function, bowel and bladder function, and sexual function before and after treatment.

this is a randomized trial to determine the comparative effectiveness of the co2re laser device relative to topical lidocaine in treating dyspareunia among breast cancer survivors. the large and growing population of breast cancer survivors experience a significant burden of urogenital symptoms including dyspareunia. several studies have evaluated the feasibility and effectiveness of co2 lasers for the treatment of symptomatic vulvovaginal atrophy in postmenopausal women suggesting improvements in atrophy symptoms with favorable histological and microscopic changes. there is little know about the effectiveness of co2 laser therapy in breast cancer survivors. patients who are breast cancer survivors experiencing dyspareunia and desiring intervention will be randomized to two cohorts: (1) treatment with the co2re laser or (2) application of 4% aqueous lidocaine applied to the vulvar vestibule for 3 minutes before vaginal penetration. the primary outcome will be the overall as well as lubrication, satisfaction, and pain domain scores on the female sexual function index instrument. secondary outcomes will be according to other validated pain and pelvic floor symptom instruments. following initiation of treatment, both groups will follow up at one-week, 1-month, 3-months, and 6-months. at the 3-month assessment, subjects in the lidocaine arm will be given the option to undergo co2re laser therapy. a combination of validated and non-validated physical exam and survey instruments will be utilized at each visit in order to assess pelvic floor function, bowel and bladder function, and sexual function before and after treatment.

Eligibility criteria:
inclusion criteria: * subjects included must be female breast cancer survivors over the age of 18, sexually active (at least 4 episodes of sexual intercourse per month), and find intercourse painful. subjects must also be english speaking and able to give informed consent. exclusion criteria: * subjects will be excluded if pregnant, has not had breast cancer, does not have painful intercourse secondary to treatment received for their breast cancer, is not english speaking, or lacks the ability to sign informed consent.

Keywords: dyspareunia laser co2 breast cancer vaginal atrophy lidocaine
evaluation of the relationship between neck pain and temporomandibular disorders in office workers

Conditions: Neck Pain; Temporomandibular Disorder

Summary: the current study aimed to explore the associations between neck pain and temporomandibular disorders in office workers

this is a cross-sectional study. all participants will provide informed consent before participating in the study. the study will be conducted in accordance with the helsinki declaration criteria. data will be collected using questionnaires, which include information on demographic, clinical conditions.

Eligibility criteria:
inclusion criteria: * aged between 18 and 55, * working on computer, * having neck pain at least three months. exclusion criteria: * reporting pregnancy, * having a history of accidents, * trauma or surgery in the neck region and temporomandibular region, * congenital anomaly of the spine or temporomandibular joint, * rheumatologic disease, * osteoporosis, * spondylosis, * spondylolisthesis, * infection of the spine or temporomandibular joint * cervical disc herniation, * tumor

Keywords: neck pain temporomandibular disorder office workers
comparative ultrasonic study of post operative diaphragmatic dysfunction in abdominal and head and neck surgery

Conditions: Diaphragmatic Dysfunction

Summary: diaphragmatic dysfunction (dd) is one of the main risk factors for post operative respiratory distress syndrome. ultrasonography is a diagnosis tool for dd but few studies have been published. the aim of this prospective study is to compare the achievement of diaphragmatic function depending on the type of surgery (abdominal and head and neck surgery).


Eligibility criteria:
inclusion criteria: * age\>18 years * upper abdominal or head and neck surgery * written consent exclusion criteria: * age \<18 years * pregnancy * history of neuropathy or myopathy, * history of diaphragm paralysis, thoracic surgery, pneumothorax, pneumomediastinum

Keywords: diaphragmatic dysfunction ultrasonography respiratory distress abdominal surgery age gender biometric body mass index asa score smoking status history of respiratory disease
a phase iii study to compare the efficacy and safety of tachosil and surgicel original as an adjunct to control mild to moderate soft tissue bleeding during surgery

Conditions: Hemorrhage

Summary: the purpose of this clinical study is to assess the efficacy and safety of tachosil compared to the widely known and used for \> 60 years local hemostatic product surgicel original as an adjunct to control mild to moderate soft tissue bleeding during surgery.


Eligibility criteria:
inclusion criteria: 1. elective open abdominal, retroperitoneal, pelvic, or thoracic surgery. elective transplant surgery except for liver or heart transplants is included. 2. the participant has a need for secondary hemostatic study intervention at the tbs with mild to moderate bleeding grade 1 and grade 2 according to the vibe scale. 3. presence of an appropriate mild to moderate bleeding soft tissue tbs identified intra-operatively by the surgeon. 4. the tbs size \< 21 cm2/3.3 in2. 5. ability to firmly press study intervention at tbs until 3 minutes after randomization. exclusion criteria: 1. participants undergoing cardiovascular, hepatic, and laparoscopic and robotic surgeries. 2. congenital or acquired disorders of coagulation. 3. diseases requiring constant use of any anticoagulant drugs that cannot be safely washed out prior to randomization. 4. screening hemoglobin \ 1.5. 5. acute major bleeding during surgery. 6. participant with tbs in an actively infected field. 7. target bleeding site is from large defects in arteries or veins where the injured vascular wall requires repair with maintenance of vessel patency. 8. target bleeding site with major arterial bleeding requiring suture or mechanical ligation. 9. bleeding site is in, around, or in proximity to foramina in bone, or areas of bony confine. 10. participants with grade '0', '3', and '4' bleeding at tbs according to vibe scale.
glutathione and function in hiv patients

Conditions: HIV Infection; Erythrocyte Glutathione Deficiency

Summary: we have recently reported that older patients with hiv are deficient in glutathione (gsh) due to decreased availability of cysteine and glycine, and that oral supplementation with cysteine (as n-acetylcysteine) and glycine for 2-weeks corrects their own levels, and improves (but does not fully normalize) concentrations of red-cell gsh. we also found that when gsh deficient, subjects had impaired mitochondrial fuel oxidation and this improved with an increase in intracellular gsh concentrations. these older hiv patients also had significant increases in muscle strength with improvement of gsh levels.the current proposal in older hiv patients will investigate study if cysteine and glycine supplementation for a duration of 12 weeks will result in changes in : (a) gsh levels; (b) body composition/anthropometry; (c) strength and function; (d) quality of life; (e) mitochondrial energetics; (f) biochemistry (including dyslipidemia and oxidative stress); (g) protein and glucose metabolism; (h) cognition and memory. after completing supplementation for 3 months, gsh concentrations, strength, function, mitochondrial energetics and neurocognitive tests will be measured for a further 2 months to determine the effects of washout.

detailed data are not as yet available

Eligibility criteria:
inclusion criteria: hiv patients: * age 45-65 years non-hiv subjects: * age 45-65 years exclusion criteria: 1. hospitalization in the past 3 months 2. untreated hypothyroidism or hyperthyroidism 3. known diabetes mellitus, hypercortisolemia, coronary artery disease. 4. known liver impairment (alt and ast \>2uln) 5. renal impairment (creatinine\>1.4) 6. inability to walk 7. patients on anticoagulation or antiplatelet therapy. 8. patient with triglyceride concentrations \>500 mg/dl.
enrichment of day centers in community-based psychiatry

Conditions: Enrichment With Meaning-generating Activities; Rehabilitation as Usual

Summary: this rct study addresses the topic of improving the possibilities for people with severe mental illness (smi) to be engaged in meaningful daily occupations at community-based activity (cba) centers. meaningful occupation, which includes not only work-related activities, but also leisure, household and social activities, is assumed to generate health and wellbeing. it is well established that there is a relationship between satisfaction with daily occupations and well-being. a swedish mental health care reform stated that the social services should provide meaningful daily occupations to people with smi. however, evaluations of the effects of the reform conclude that the target group's needs for meaningful daily occupation have not been met. thus, on the basis of governmental reports and evaluations, there is an urgent need for improving the quality of the activities and support offered at cba centers. therefore, the overarching aim of this project is to develop and implement an intervention method for improving the activities offered and support given at cba centers, and evaluate the outcomes of that intervention. specific aims * developing and implementing an intervention that means reorganization of cba centers in such a way that they become enriched with characteristics that have been identified as rewarding and meaningful in previous research. * evaluating the outcome of that intervention on: * the unit level, i.e., in terms of changes in the characteristics of the cba centers, * the individual level, in terms of changes among the consumers regarding satisfaction with the activities at the cba center, perceived control, social interaction, quality of life, etc. cluster randomization is used. day centers are randomized to either giving the new intervention ("enrichment") or continuing with "care as usual" during the study period, which is 14 months. this means that all participants in a day center get the type care their specific day center offers during the study period.


Eligibility criteria:
inclusion criteria: * severe mental illness \> 2 years * age 18-65 years * visiting the day center \> 4 hrs per week exclusion criteria: * comorbidity of dementia or developmental disorder * acute psychosis * primary diagnosis of substance use disorder * insufficient knowledge of swedish

Keywords: everyday activities rehabilitation mental illness occupational therapy
effects of preventive physiotherapy practices on posture and work-related functions in office workers

Conditions: Work-related Musculoskeletal Disorders; Office Workers

Summary: in this study; aimed to determine an individual-centered, effective physiotherapy method to reduce the negative impacts of the forward head posture on work-related functions and to increase body awareness and functionality among office workers. in addition, aimed to reduce the loss of work with measures to improve the quality and efficiency of work.

the purpose of this study is to determine the effects of preventive physiotherapy practices on work related musculoskeletal disorders in office workers. with this purpose, in this study; aimed to achieve improvement on forward head posture, upper extremity functions and cervical pain reduction through three interventions (supervised emg biofeedback exercise training, home-based exercise program and posture training/ergonomic regulations). work related changes in muscle activation of upper trapezius and posture will be evaluated while working on a computer task in actual work environment. differences in posture and muscle activation between computer task and resting position, will be determined before and after the intervention.

Eligibility criteria:
inclusion criteria: * age below 40, full-time and regular employees in the last 1 year, * office workers using computers at desk for at least 3 hours per day * according to rula, working in a posture that above acceptable level, * no trauma history * non-specific neck pain but no chronic conditions of cervical spine and upper extremity exclusion criteria: * during the study; need of receiving a treatment/ interventions for the upper body due to trauma or any other conditions is concluded with withdraw from the study

Keywords: surface electromyography biofeedback forward head posture posture trapezius muscle task- specific performance exercise office worker
comparison of efficacy, safety and anti-inflammatory effect between topical 0.05%cyclosporine a emulsion and refresh® in patients with moderate to severe dry eyes

Conditions: Dry Eye

Summary: to compare the efficacy, safety and tolerability of 0.05% topical cyclosporin eye drop to refresh in moderate to severe dry eye patients. null hypothesis is: there is no difference between these two groups.

inclusion criteria: 1. participants are moderate to severe dry eye patients aged more than 18 years of age 2. oxford staining scores of more than five. 3. osdi scores of more than 0.1 outcome measurements: main parameter is staining score (corneal + conjunctival) other parameter is osdi score, symptom of ocular surface discomfort score, number of daily artificial tear needed, tbut, schirmer i score, cytokines level \& markers safety parameters: va, iop, cyclosporin level

Eligibility criteria:
inclusion criteria: * moderate to severe dry eye exclusion criteria: * lid anomaly, previous csa use

Keywords: dry eye
safety/efficacy of sitagliptin in patient w/ type 2 diabetes (0431-801)

Conditions: Type 2 Diabetes Mellitus

Summary: the purpose of this study is to test the safety and effectiveness of sitagliptin in patients with type 2 diabetes.


Eligibility criteria:
inclusion criteria: * patient has type 2 diabetes * currently taking metformin \>1500 mg/day for at least 10 weeks * male or female exclusion criteria: * patient has peripheral edema * history of type 1 diabetes * patient required insulin within prior 8 weeks * have participated or are currently participating in another study with an investigational compound or device within 12 weeks of starting this study * participating in a weight loss program
myocardial stress perfusion computed tomography in the evaluation of patients with acute chest pain using a novel 3rd generation dual-source ct system

Conditions: Chest Pain

Summary: to assess the ability of a novel 3rd generation dual-source ct system to demonstrate myocardial perfusion in a cohort of patients presenting to the chest pain center with acute chest pain.

the investigators will assess the latest generation of ct scanner for heart disease detection. on this new machine the investigators will analyse the ability of the machine to show the delivery of blood to the heart muscle. results will be compared with the results from the gold standard test for myocardial perfusion imaging, which is an imaging test that shows the blood supply to the heart muscle. further analyses will record the amount of radiation, which is how the ct machine acquires images, and compare the amount of radiation necessary to produce images to previous ct systems. with this new ct system there should be reductions in the amount of radiation dose compared to previous systems.

Eligibility criteria:
inclusion criteria: * subject must present with symptoms of acute but atypical or recurrent chest pain. * subject must have been referred for cardiac ct angiography or subject must have undergone clinically indicated spect with positive or equivocal findings or subject must have undergone clinically indicated spect with prior cardiac ct angiography that showed moderate or severe stenosis. * subject must be 18-85 years of age. * subject must provide written informed consent prior to any study-related procedures being conducted. * subject must be willing to comply with all clinical study procedures. exclusion criteria: * subject is a pregnant or nursing female. * subject has severe asthma or copd requiring frequent inhaler use. * subject has prior diagnosis of obstructive cad that has not been revascularized. * subject with implanted rhythm devices (pacemaker, defibrillator). * subject has significant arrhythmia. * subject has high grade heart block. * subject has resting heart rate \< 45 bpm, systolic blood pressure \<90 mm hg, or has consumed caffeine within the last 12 hours. * subject has an acute psychiatric disorder. * subject is unwilling to comply with the requirements of the protocol. * subject has previously entered this study. * subject has an allergy against iodinated contrast or pharmaceutical stressors used in this study. * subject suffers from claustrophobia. * subject has impaired renal function (creatinine \> 1.5 mg/dl). * subject is in unstable condition. * st-elevations, new transient st changes greater than 0.05mv or t-wave inversions with symptoms. * subject cannot safely be administered lexiscan per prescribing information as as determined by investigator. * subject has received interventional (pci, stenting) or surgical (cabg) treatment that may alter the cardiac condition regarding myocardial perfusion status and/or stenosis degree between cardiac cta, spect, and/or ct stress perfusion studies.
mobile smoking treatment for spanish-speaking latinx smokers

Conditions: Smoking Cessation

Summary: the specific aims of the project are to develop and test a spanish language, mobile app for smoking cessation called impacto.

a total of 38 spanish-speaking, latinx smokers with high anxiety sensitivity (as) will be recruited for this project. eight (8) participants will complete user interviews in spanish and thirty (30) participants will participate in a randomized controlled trial (rct) for smoking cessation. participants will be randomized to receive either the impacto mobile app or a generic, spanish language, smoking cessation, mobile app control (dejar de fumar asistente).

Eligibility criteria:
inclusion criteria: 1) 18 to 55 year of age, 2) current smoker (i.e., at least 6 cigarettes/day), 3) not currently engaged in smoking cessation treatment, 4), high anxiety sensitivity (as) score defined as an asi-iii score of ≥ 23, 5) motivation to quit \> 5 on a 10 pt. scale, 6) spanish speaking, and 7) currently own an android-compatible mobile phone. exclusion criteria: 1) use of other tobacco products (including e-cigarettes), 2) current non-nicotine substance dependence and/or current or intended participation in a concurrent substance abuse treatment, 3) ongoing psychotherapy of any duration directed specifically toward the treatment of anxiety or depression, or 4) active suicidality (i.e., suicidal ideation, intent, and/or plan) or current psychosis

Keywords: smoking cessation mobile app anxiety sensitivity
ischaemic stroke and sleep apnea in northern part of finland

Conditions: Sleep Apnoea; Cerebral Palsy

Summary: obstructive sleep apnoea is a risk factor for ischaemic stroke. study hypothesis: in prospective study the investigators want to know how many ischaemic stroke patients have sleep apnoea and does thrombolysis play a role in severity of osa in six months follow up.

in prospective study the investigators include all over 18 years old patients who came to emergency room for ischaemic stroke. exclusion criteria is not able to co-operate or need for intensive care unit.the investigators shall take 100 control patients who have ischaemic stroke and no thrombolysis and 100 study patients who will have thrombolysis. the investigators do sleep registration during hospital staying within 2 days after patients have felt ill.follow-up registration will be done after 6 months at home.

Eligibility criteria:
inclusion criteria: * over 18 years old patients that have cerebral palsy and are able to participate to the study. exclusion criteria: * no co-operation and need for intensive care unit

Keywords: osa cerebral palsy thrombolysis in cerebral palsy sleep registration
nk cell deregulation in hbv patients

Conditions: Hepatitis B Virus

Summary: natural killer (nk) cells play a large role in the innate immune response as they are equipped to kill infected or tumor cells. they express a panel of activating and inhibitory receptors that regulate the destruction of the target cell. many reports have shown that nk cell function is suppressed in chb patients. exhaustion occurs when activating receptors become over stimulated leading to the loss of nk function. the investigators hypothesize that nk cells are rendered dysfunctional/ exhausted by hbv. the primary objective is to determined the phenotypical modifications and mechanisms associated to nk cell dysfunction, during different phases of chb infection, in not treated patients.

using a previous cohort from the limoges hospital, the investigators have identified by multi-parametric flow cytometry phenotypic, cytokine and signaling molecules that are altered in nk cells from chb patients during the inactive phase. phenotypic changes observed include the downregulation of cd160, nkp30, cd16 and tim-3. the expansion of 'adaptive' nk cells (fcεrg- nkg2c+ or cd57hi), and the upregulation of cd107a (steady state), nkg2d and 41bb. functional changes include the decrease in the levels of ifnγ, tnfα and mip1β. cellular metabolism is now recognized to regulate functional properties of immune cells such as t or nk cells. the mammalian target of rapamycin (mtor) kinase is a key regulator of cellular metabolism, integrating environmental cues to control downstream metabolic pathways. mtor is the catalytic subunit of two different complexes: mtorc1 and mtorc2, the activity of which can be measured by measuring the level of phosphorylation of the proteins s6 and akt respectively. the lab has previously shown that the mtor pathway regulates nk cell development and activation 2. the investigators have observed that ps6 and pakt are also decreased in chb patients.

Eligibility criteria:
inclusion criteria: patients must meet all of the following inclusion criteria to be eligible for participation in this study: * male or female, age ≥18 years * hbv infection or chronic hbv infection * willing and able to provide written informed consent healthy donors must meet all of the following inclusion criteria to be eligible for participation in this study: * male or female, age between 18 and 50 years * willing and able to provide written informed consent exclusion criteria: * subjects who meet any of the following exclusion criteria are not to be enrolled in this study: * infection with hepatitis c virus (hcv) or human immunodeficiency virus (hiv) * chronic liver disease of a non-hbv etiology * immune or cancerous disease

Keywords: hepatitis b virus - natural killer