Kornimate/medical-research-clean huggingface dataset:
the effect of catheter-associated infection control training

Conditions: Infection Control Training

Summary: the goal of this type of study: clinical trial is to determine the effectiveness of educational practices on catheter-associated infection control measures on surgical nurses. the main question it aims to answer are: * is there a difference between the knowledge and attitude levels of surgical nurses receiving and not receiving catheter-related infection control training on preventing peripheral and central catheter-related bloodstream infections? * is there a difference between the knowledge and attitude levels of surgical nurses receiving and not receiving catheter-related infection control training to prevent catheter-related urinary tract infections? the main tasks that the participants will be asked to do will be explained and their consent will be obtained. the two research groups will be compared.

this study will be conducted with a total of 70 nurses working in the surgical clinics of a city hospital in istanbul and meeting the inclusion criteria. nurses who meet the inclusion criteria of the study will be divided into two groups: intervention (n=35) and control group (n=35) according to the randomization method created with computer-based random numbers. nurses in the intervention group will be given face-to-face training on evidence-based catheter-related infection control measures. the content of the training program will also be given to the participants as written material (brochure). the training will take an average of 30 minutes. routine in-service training practices will be given to the control group. descriptive characteristics form, the peripheral and central venous catheter-related bloodstream infection prevention knowledge and attitudes scale, and catheter-associated urinary tract infections control precautions will be used in data collection. data will be collected from all participants before, immediately after, and three months after the training practices.

Eligibility criteria:
inclusion criteria: * being a nurse * working in the surgical unit * agreeing to participate in the research exclusion criteria: * being on leave/reported (maternity leave, unpaid leave, medical report, etc.) * not filling out the questionnaire

Keywords: attitude, infection, knowledge, surgical nursing
autologous antigen-activated dendritic cells in the treatment of patients with breast cancer

Conditions: Breast Cancer

Summary: the purpose of this work: to assess the tolerability and effectiveness of the autogemotherapy method on the basis of autologous antigen-activated dendritic cells in the treatment of patients with breast cancer. this technology is intended for complex treatment of patients with breast cancer and is aimed at preventing the occurrence and treatment of secondary foci. the need for this technology is justified by the widespread occurrence of breast cancer among women, a decrease in the average age at onset of the disease and a young age, and the chemoresistantness of locally advanced forms of cancer.

currently, technologies are being developed to improve the clinical outcomes of patients with complex treatment of breast cancer. many patients are immunosuppressed after surgical, radiation and chemotherapeutic treatment, which leads to dysfunction of t cells, resulting in tumor cells avoiding immune surveillance. restoration of antitumor immunity during immunotherapy is one of the modern approaches in the treatment of breast cancer, which contributes to the formation of an effective specific immune response, the destruction of tumor cells while minimizing toxicity. dendritic cells (dc) and the lymphocytes induced by them are one of the most effective methods for the destruction of residual cancer cells, which are the leading cause of relapse and metastasis.

Eligibility criteria:
inclusion criteria: 1. for the first time established morphologically confirmed diagnosis of breast cancer 2. patients with ii a, ii b, iiia, iii b stages of breast cancer; 3. patients with progressive or primary iv stage of breast cancer with cytologically confirmed and accessible soft tissue metastases; 4. patients with her-2 / neu 3 + positive and patients with triple negative breast cancer of the i-ii stage (biologically unfavorable forms of breast cancer more prone to recurrence and metastasis). 5. absence of severe somatic pathology in which medical intervention (at the stage of obtaining biological material or the stage of immunotherapy) will only worsen the patient's condition, 6. the patient's desire. exclusion criteria: 1. pregnancy at any time, 2. impossibility of correction of therapy of concomitant diseases, if the taken preparations are proved to influence the immune status, 3. rapid progression of the underlying disease, in which the use of immunotherapy is deontologically unjustified, 4. individual intolerance to the components of the vaccine and / or the development of severe side effects on any of the components, 5. refusal of the patient to participate in the study in oral or written form. 6. patient involvement in any other clinical study (including those that the patient has not been informed by the direct oncologist who has been treated, but which has become known already after the beginning of any stage of the study).

Keywords: dendritic cell, il-12, il-18, сytotoxicity
a prospective study of a new device for monitoring cerebral oxygenation on healthy volunteers

Conditions: Cerebral Ischemia

Summary: the purpose of this study is to determine whether a new cerebral oxygen monitoring device is effective and comparatively similar to the current approved devices.

cerebral oxygenation monitoring is an innovative way to monitoring cardiac surgery patients intraoperatively to reduce the incidence of postoperative hypoxic side effects. there are a number of approved devices already in the market that have proved their effectivity.

Eligibility criteria:
inclusion criteria: * healthy male or female volunteers * 18 years old or older * capable and willing to operate a bicycle * understand enough about the risks and benefits of the study to be able to make an informed decision before agreeing to be in the study exlusion criteria: * history of cerebrovascular disease * history of skin problems on forehead (skin rashes, acne, allergies, etc.) * pregnancy

Keywords: cerebral oxygenation oxygen monitoring
hereditary paraganglioma: evaluation of screening methods to detect tumors in sdh positive carriers

Conditions: Paraganglioma; Pheochromocytoma

Summary: hereditary paraganglioma -due to sdh (sdhd, sdhb, sdhc) germline mutations- causes paragangliomas and pheochromocytomas. presymptomatic genetic testing should be offered to all first-degree relatives if an sdh mutation is detected in an index case with paraganglioma or pheochromocytoma. the main objective of our national clinical research project is to test different screening methods to detect presymptomatic tumors in order to establish guidelines for the work-up and the follow-up of sdh mutation carriers.


Eligibility criteria:
inclusion criteria: identification of an sdh (sdhd, sdhd, sdhc) germline mutation
role of octreotide in non variceal bleeding

Conditions: Non-variceal Gastrointestinal Bleeding

Summary: the rationale for using somatostatin (octreotide0 is that it has been shown to inhibit the secretion of various gastrointestinal hormones, including gastrin and secretin, which can contribute to the development of non-variceal gastrointestinal bleeding (nvgib). somatostatin has also been found to reduce splanchnic blood flow, which can decrease the risk of rebleeding in patients with nvgib. previous studies have suggested that somatostatin may be effective in reducing the risk of rebleeding in patients with nvgib, but there is a lack of high-quality randomized controlled trials evaluating its efficacy. therefore, this study aims to provide more rigorous evidence regarding the use of somatostatin in the management of nvgib. aim of the study: to evaluate the efficacy of medical treatment with somatostatin analogue (octreotide) combined with ppi in the treatment of non-variceal gastrointestinal bleeding in comparison to ppi alone a randomized.

all patients admitted will receive the routine monitoring for the vital signs and supportive treatment. resuscitation of a hemodynamically unstable patient begins with assessing and addressing the "abcs" (i.e. airway, breathing, circulation) of initial management. patients who are at an increased risk for aspiration, should be electively intubated. intravenous access will be inserted and fluid resuscitation, blood, and blood products transfusion according to laboratory results. nasogastric tune will be inserted andperform lavage, and endoscopic consultation post resuscitation within 24 hours. enrolled patients were assigned to one of two groups. after the initial endoscopy, both groups received either an 80-mg bolus of ppi alone (control group= a), followed by continuous intravenous (iv) infusion at 8 mg/h for a total of 72 hours or the octreotide adjunctive group, in addition to the pantoprazole (study group= b) for 72 h, received a 100-μg bolus of octreotide, followed by continuous iv infusion of 50 μg/h for a total of 72 hours. hourly monitoring for vital signs including pulse, blood pressure, respiratory rate, oxygen saturation by pulse oximetry, 24hours urine output. daily follow up for complete blood count, coagulation profile, urea, and creatinine will be done.

Eligibility criteria:
inclusion criteria: * the subjects are adults aged ≥18years old * admitted to the intensive care unit of the national hepatology and tropical medicine research institute and alexandria university presenting with acute non-variceal gastrointestinal bleeding exclusion criteria: * if they have variceal bleeding * received active endoscopic treatment (e.g. hemoclips or monopolar coagulation) * known hypersensitivity to somatostatin analogue (octreotide) or any of its components * pregnancy or breastfeeding * active malignancy * and use of somatostatin analogue within the past 7 day.
comparative evaluation of the mcgrath videolaryngoscope and the direct laryngoscopy for tracheal intubation in the prehospital setting

Conditions: Indication of Orotracheal Intubation; Cardio Respiratory Arrest; Respiratory Failure; Neurological Failure

Summary: in the prehospital setting, the risk of difficult intubation and life-threatening complications is increased under particular conditions due to the environment or the frequent instability of patients. to limit this risk procedures and devices to ease and secure tracheal intubation must be developped and integrated. as the prevalence of complications increase with the number of attempts of intubation, one strategy is to facilitate the intubation technic itself. direct laryngoscopy with macintosh blades is the standard device commonly used in first place for tracheal intubation. other devices are available and used, mostly for difficult intubation, included videolaryngoscopy. this device has been used and studied for years now. allowing a better view and glottic visualisation, videolaryngoscopy could increase the first-pass success rate. among all videolaryngoscopes, the mcgrath videolaryngoscope is the most similar device to the standard macintosh laryngoscope. it is light, compact, with a screen directly linked to the handle, easy to use and offering excellent view. its usability and efficacy make it a device of choice for the prehospital setting and worth further clinical trials to define its place in the airway strategy. hypothesis: in the prehospital setting, the use of mcgrath videolaryngoscope as the primary device for tracheal intubation could facilitate tracheal intubation and decrease the number of attempts of intubation and complications. the objective of our study is to determine if the use of mcgrath videolaryngoscope increase the rate of successful first-pass intubation in the prehospital setting compared to direct view macintosh laryngoscopy. the primary outcome is the rate of successful intubation at the first attempt. one attempt is defined as an advancement of the tube towards the glottis during a laryngoscopy ; every new try even during the same laryngoscopy is considered as a new attempt. successful intubation is confirmed by the visualisation of 6 waves of etco2.


Eligibility criteria:
inclusion criteria: * age more than 18 * indication of orotracheal intubation * operators trained to the use of the mcgrath exclusion criteria: * pregnancy * no insurance * major patient under guardianship or curatorship
a single-center, prospective, pilot study to compare the effect of diet in overweight or obese patients with psoriasis on light therapy

Conditions: Psoriasis

Summary: weight loss may help psoriasis. phototherapy helps psoriasis. combining the two treatments may help even more. determining if a high protein diet vs a low protein diet results in improving psoriais may help lead to future dietary effects on psoriasis therapy


Eligibility criteria:
inclusion criteria: * psa greater 10 * bmi greater than 30 exclusion criteria: * psa less than 10 * less than 18 years old

Keywords: psoriasis
integrative intervention strategies for binge eating in patients with overweight or obesity

Conditions: Binge Eating; Overweight and Obesity

Summary: the main goal of the clinical trial is to compare the short- and long-term outcomes of three 12-week interventions among outpatients with overweight/obesity and binge eating (be): 1. treatment-as-usual for weight loss (tau); 2. combined tau and guided self-help for improving eating behaviors (tau+gsh); 3. combined tau, gsh, and biofeedback (tau+gsh+bf). the primary outcomes will be self-reported reduction of days with objective be episodes (obes). the secondary outcomes will be impulsivity, emotion dysregulation, interoceptive awareness, distress, physiological correlates of arousal (skin conductance and heart rate variability), and inflammatory biomarkers. the tau+gsh arm is expected to be comparable to the tau+gsh+bf arm in reducing the number of days with obes but is expected to be significantly less effective in improving secondary outcomes (impulsivity, emotional dysregulation, interoceptive awareness, distress, physiological inflammatory markers). the tau arm is expected to show significant inferiority regarding the primary and secondary outcomes and cost-effectiveness compared to the tau+gsh and tau+gsh+bf conditions.


Eligibility criteria:
inclusion criteria:(1) age 18-65 years; (2) bmi≥25 kg/m2; (3) ability to read and write in italian; (4) binge eating disorder (bed) or subthreshold bed status. - exclusion criteria: (1) current treatment for be with a registered psychologist; (2) severe psychiatric disorders; (4) cognitive impairment; (5) pregnancy; (6) severe medical comorbidity. -

Keywords: binge eating overweight obesity guided self-help biofeedback
using a lay health worker program to increase breast and cervical cancer screening in low-income hispanic women

Conditions: Breast Cancer; Cervical Cancer

Summary: the primary purpose of this study is adapt the cultivando la salud (cls) intervention for a new community and priority population and to train community health workers (promotoras) from the prosalud promotora program to implement the adapted cls breast and cervical cancer screening program. the adaptation and delivery of the cls intervention program focuses on meeting the needs and supporting of chws and hispanic/latina women in the greater houston area. finally, this study aims to evaluate the process and effect of the adapted cls program (renamed salud en mis manos (semm) on increasing mammography and cervical cancer screening.

chws identify women in the community in need of breast and/or cervical cancer screening. based on their screening needs, they invite women to participate in the cls behavioral intervention. women are randomized to intervention and usual care comparison (delayed intervention) groups. after women are consented to participate in the study, the study team administers the baseline survey. after the baseline survey is administered, the cls-adapted intervention (renamed salud en mis manos), is delivered to participants randomized to the intervention group. after the follow-up survey is administered to the participants, women in the comparison group are offered the cls (semm) intervention.

Eligibility criteria:
inclusion criteria: * women who identify as hispanic/latina ancestry or descent and live in the greater houston area in texas * no previous diagnosis of breast or cervical cancer exclusion criteria: * pregnant women, and women who are adherent to screening guidelines * prior or current cancer diagnosis

Keywords: mammogram pap test
magnetic resonance guided focused ultrasound for uterine fibroids

Conditions: Uterine Fibroids

Summary: this is a pilot randomized, blinded, placebo-controlled trial of a noninvasive, fda approved treatment for uterine fibroids called mr guided focused ultrasound (mrgfus). our hypothesis is that mrgfus provides superior relief of fibroid symptoms compared with the placebo, a sham mrgfus treatment. the investigators will recruit 20 premenopausal women with symptomatic uterine fibroids to participate in the trial. participants will be randomly assigned in a 2:1 ratio to the active treatment arm (mrgfus) versus the sham mrgfus treatment. participants will remain blinded to their group assignment for 3 months. after 3 months, participants will be told their treatment group and those assigned to the sham group will be offered complimentary mrgfus if they desire it. women will be excluded if they are inappropriate candidates for a 3 month delay in fibroid treatment, such as those with significant anemia. the investigators will assess the change from baseline to 1 and 3 months after treatment in fibroid symptoms, quality of life, fibroid volume measured by mri, and hematocrit.


Eligibility criteria:
inclusion criteria: * age\>18 years * premenopausal * symptomatic fibroids * fibroids accessible for focused ultrasound treatment exclusion criteria: * desires future fertility * current pregnancy * hematocrit \<30% * emergency room visit in last 3 months for fibroid symptoms * history of venous thromboembolism * fibroids that are: \>10cm, non-enhancing with contrast * adenomyosis * contraindications to undergoing mri * unexplained menstrual irregularity

Keywords: fibroids uterine focused ultrasound magnetic resonance focused ultrasound hifu noninvasive treatment
evaluation of a personalized physical activity coaching program in parkinson's disease

Conditions: Parkinson's Disease

Summary: there is growing interest for physical activity in parkinson's disease in order to improve mobility and function of these patients. it seems from previous studies that difficulty, intensity and specificity of physical exercises are important parameters conditioning the effect of physical activity on cerebral plasticity and clinical improvement. thus, the aim of this study is to evaluate the benefits of a personalized physical activity coaching program, including scheduled and frequent follow up associated with progressive readaptation of exercise intensity depending on individual performances (during 3 months), versus free practice of physical activity in parkinson's disease.

type of study: a randomized, single-blind, parallel-group, controlled clinical trial. number of centers: 1 (clermont-ferrand) patients patients eligible for inclusion will be randomized to one of the two groups: * apa + : patients will beneficiate of personalized physical activity coaching program during 3 months (1 hour, twice by week, during 3 months) * apa- : patients will do free practice of physical activity during 3 months. study performance patients will be evaluated 3 times : at j0 (baseline, v1), 3 months after personalized physical activity coaching program (j0+3m, v2), and 3 months after the end of the personalized physical activity coaching program (j0+6m) v1: * signature of an informed consent form. * demographic and clinical characteristics (sex, age, disease duration, treatments). v1, v2, v3 * neurological evaluation (unified parkinson disease rating scale part iii score) * evaluation of quality of life (parkinson's disease questionnaire 39-item version (pdq-39), participation to daily life activities (lawton and brody activities of daily living scale (iadl questionnaire25) * evaluation of performances for specific tests for balance (stabilometry), muscular strength (isometry) * evaluation of cardiorespiratory function (vo2pic et 6 min walk test) * evaluation of body composition (lean body mass/fat mass) with dexa. * dropout rates at v2 and v3 * evaluation of the activity with the emouve application in a subgroup of patients.

Eligibility criteria:
inclusion criteria: * clinical criteria for parkinson's disease * men or women aged from 18 to 80 years old. * social security coverage. * ability to provide informed consent. exclusion criteria: * neurological disease other than parkinson's disease * severe depression (beck depression inventory\>37) or psychiatric comorbidities (updrs i ) * significant cognitive impairment (moca\<24) * orthopedic impairment with functional restriction * contraindication to physical exercise

Keywords: parkinson's disease physical activity physical exercise