Kornimate/medical-research-clean huggingface dataset:
measuring the balance improvement on multiple sclerosis patients after a short training period with an apos (all phase of step cycle) kit

Conditions: Multiple Sclerosis; Balance; Cerebelar Impairment

Summary: randomised double blind study of two parallel groups,one of the groups trained with the full apos kit (a shoe with an additional bio mechanical device) the control group trained with the apos shoe without the bio mechanical device. both groups will be checked at the beginning of the study, one month later and at the end of the study after two months. the tests include neurological test, functional test(fsst,up and go test and berg balance test) gate analysis and quality fo life (rays) test.


Eligibility criteria:
inclusion criteria: * diagnosis of multiple sclerosis cerebellar impairment edss under 4.5 age 18-65 years signed informed consent form exclusion criteria: * pregnancy * coronary event in last 6 month * 30 days or less after acute attack * steroidal treatment in the last 60 days * alcohol abuse
hemodynamic assessment during spinal anesthesia using transthoracic echocardiography'

Conditions: Hypotension; Hypovolemia

Summary: rationale: spinal anesthesia is a safe, frequently used anesthetic technique. the main side effect of spinal anesthesia is hypotension, occuring in up to 85 % of selected cases. this hypotension is often treated with fluid infusion. however, especially in elderly patients, high volume fluid infusion can lead to fluid overload. the effects of spinal anesthesia on preload and fluid responsiveness are not exactly known. hence, therapy for hypotension after spinal anesthesia might not be adequate. with transthoracic echocardiography, vena cava inferior diameter and collapsibility can be used to monitor fluid responsiveness and guide fluid management. objective: this study has two main objectives. the first is to explore the effects of spinal anesthesia on hemodynamic parameters of fluid status, especially vena cava inferior diameter and collapsibility. the second goal is to test the interrater variability transthoracic echocardiography exams when performed by (trained) anesthesiologists. furthermore, the correlation between vena cava inferior collapsibility and the occurence and degree of hypotension (defined as a decrease from baseline of \>20% or a systolic pressure \< 90 mmhg) after spinal anesthesia will be explored.


Eligibility criteria:
inclusion criteria: * adult age (\>18 years) * written informed consent * minor surgery under the umbilicus, e.g. herniorrhaphy, transurethral resection of bladder or prostate, orthopaedic procedures * asa class i or ii exclusion criteria: * no informed consent * asa class iii or higher * obstetric surgery * emergency procedures * pre-existing neurological injury or disease * contra-indications for spinal anesthesia (e.g. coagulation abnormalities)
clinical implications of fkbp5 in stroke

Conditions: Stroke

Summary: with contemporary lifestyle changes and global aging, it is important yet unknown how stress interacts to post-stroke outcomes. this proposal aims to study the link between the stress-responsive fkbp51-related pathways and neural plasticity after stroke, elucidating fkbp5 gene polymorphisms and blood fkbp51 regulation in relation to brain excitability and functions, understanding the effects of transcranial direct current stimulation, and characterizing brain mechanisms for individualized early rehabilitation after stroke.

stress is an underestimated risk factor and also a consequence of cardiovascular diseases and stroke. fk506-binding protein 51 (fkbp51) modulates stress responses by acting as a co-chaperone that negatively regulates glucocorticoid receptor (gr) to cortisol binding and nuclear signaling. in an oxygen-glucose deprivation (ogd) model of acute mouse hippocampal slices, fkbp5 deletion reduced ischemic neuronal hyperexcitation, and cathodal electrical stimulation of ogd-injured wild-type decreased fkbp51 levels. however, clinical implications of fkbp5 polymorphisms and fkbp51 regulation in post-stroke outcomes and neuromodulation-induced plasticity are unknown. we aim to assess the link between fkbp5 polymorphisms and blood fkbp51 regulation after stroke, and their relationship with stroke phenotypes, brain connectivity and functional outcomes.

Eligibility criteria:
inclusion criteria: * unilateral ischemic or hemorrhagic stroke * aged 20-80 years old exclusion criteria: * fma-ue is over 49 points * major psychiatric diseases * major neurologic diseases * global aphasia

Keywords: stroke fkbp5 motor transcranial direct current stimulation plasticity stress
a one-year study to evaluate the efficacy and safety of cp-690,550 for patients with moderate to severe chronic plaque psoriasis

Conditions: Psoriasis

Summary: the main objective of this study is to compare the effects of cp-690,550 with the effects of placebo in patients being treated for moderate to severe chronic plaque psoriasis. this one-year study will also evaluate the safety and tolerability of cp-690,550 versus placebo.


Eligibility criteria:
inclusion criteria: * 18 years or older with diagnosis for at least 12 months of moderate to severe plaque psoriasis covering at least 10% of body surface area * a psoriasis area and severity index (pasi) score of 12 or greater * are considered to be candidates for systemic or light therapy * have no evidence of active or latent tuberculosis exclusion criteria: * non-plaque or drug-induced forms of psoriasis * cannot discontinue current oral, injectible or topical therapy for psoriasis or cannot discontinue phototherapy (puva or uvb) * any uncontrolled significant medical condition

Keywords: xeljanz tofacitinib jak-inhibitor oral treatment chronic severe moderate pruritus itch dlqi treatment safety efficacy cp-690,550 plaque psoriasis psoriasis vulgaris
assessment of the safety of abt-308 in healthy volunteers and subjects with asthma

Conditions: Asthma

Summary: the primary purpose of this study is to determine the safety, tolerability and pharmacokinetics of abt-308 in healthy volunteers and patients with mild to moderate controlled asthma.


Eligibility criteria:
inclusion criteria: * healthy volunteers: 1. a condition of good health based upon the results of medical history, physical examination, vital signs, laboratory profile and ecg. 2. bmi 18 to 29, inclusive. * mild asthma patients: 1. diagnosis of well-controlled, mild to moderate asthma by gina guidelines for \> or = to 6 months 2. a condition of good health (than mild to moderate asthma) based upon the results of medical history, physical examination, vital signs laboratory profile and edg. 3. bmi 18 to 34, inclusive. exclusion criteria: 1. asthma exacerbation within 8 weeks of study day 1. 2. clinically significant allergic reaction to any drug, biologic, food, or vaccine. 3. history of allergic reaction or significant sensitivity to constituents of study drug. 4. receipt of any investigational product within 30 days or 5 half-lives (whichever is longer) prior to study drug administration. 5. subject is a smoker or has a history of smoking within the 6-month period preceding study drug administration. 6. current enrollment in another clinical study.

Keywords: adverse events pharmacokinetics
a dose-finding study of mk0974 in acute migraine (mk0974-004)

Conditions: Migraine

Summary: the purpose of this study is to investigate the efficacy and safety of an mk 0974 for migraine headache and to identify an appropriate dose range for further study.


Eligibility criteria:
inclusion criteria: * patient has at least 1 year history of migraine (with or without aura) * females of childbearing years must use acceptable contraception throughout trial * patient is in general good health based on screening assessment exclusion criteria: * patient is pregnant/breast-feeding (or is a female expecting to conceive during the study period) * patient has heart disease, uncontrolled hypertension (high blood pressure), uncontrolled diabetes or other significant disease * patient has major depression, other pain syndromes that might interfere with study assessments, psychiatric conditions, dementia, or significant neurological disorders (other then migraine) * patient has a history of gastric or small intestinal surgery or has a disease that causes malabsorption * patient has a history of cancer within the last 5 years
effects of regular submaximal exercise on asthma control and quality of life in patients with persistent symptoms

Conditions: Chronic Asthma

Summary: the effects of regular exercise on asthma control has not yet been well demonstrated. the aim of this study is to investigate the impact of submaximal physical exercise on quality of life, on symptomatic control, and on bronchial and systemic inflammatory markers in patients with persistant asthma.

while it is well known that intense physical exercise can generate bronchospasm and limit exercise performance, it recently appeared that regular physical exercise practiced aerobically could improve the clinical status of asthmatic patients. the investigators are planning a 12-week randomized controlled study to assess the effect of regular aerobic exercise on quality of life, asthma control, bronchial hyperresponsiveness and bronchial and systemic inflammation in patients with persistent asthma the hypothesis is that regular physical exercise increases control and quality of life and reduces inflammation and bronchial hyperresponsiveness compared to simple physiotherapy sessions.

Eligibility criteria:
inclusion criteria: * asthmatic patient * aged 18- 90 years * acq \> 1.5 * stable background treatment comprising at least one inhaled corticosteroid or an anti-leukotriene exclusion criteria: * imc \> 35 * severe osteoarthritis of the knees and hips * unstable angor * severe uncontrolled hypertension
mode of action study of omalizumab in patients with chronic idiopathic urticaria (ciu) who fail to respond to antihistamine treatment

Conditions: Chronic Idiopathic Urticaria

Summary: the study is designed to explore the mode of action for omalizumab therapy in patients with chronic idiopathic urticaria.


Eligibility criteria:
inclusion criteria: * diagnosis of chronic spontaneous urticaria refractory to h1 antihistamines at baseline exclusion criteria: * clearly defined underlying etiology for chronic urticarias other than ciu (main manifestation being physical urticaria). this includes the following urticarias: acute, solar, cholinergic, heat, cold, aquagenic, delayed pressure or contact, as well as the following diseases as these diseases may have symptoms of urticaria or angioedema: urticarial vasculitis, urticaria pigmentosa, erythema multiforme, mastocytosis, hereditary or acquired angioedema, lymphoma, leukemia, or generalized cancer. * previous treatment with omalizumab. * a history or presence of atopic dermatitis, bullous pemphigoid, dermatitis herpetiformis, senile pruritus or other skin disease associated with itch. other protocol-defined inclusion/exclusion criteria may apply.

Keywords: chronic idiopathic urticaria ciu xolair ige025 fcεri ige
pediatric integrative manual therapy in babies with deformational plagiocephaly and congenital muscular torticollis

Conditions: Plagiocephaly, Nonsynostotic; Plagiocephaly, Positional; Congenital Muscular Torticollis

Summary: this study evaluates the efficacy of pediatric integrative manual therapy in the treatment of positional plagiocephaly in infants. 25 participants will receive a protocol of pediatric integrative manual therapy and educational physiotherapy in combination, while the other 25 will receive a stretching protocol and educational physiotherapy

the manual therapy has shown efficacy in different pathologies in the adult but it is not know its utility in infants and children population, nor in specific pathologies as non synostotic plagiocephaly. in the conservative treatment of plagiocephaly the educational physiotherapy and the helmet therapy have the better level of evidence among other treatments. when babies present preferential position of the head or congenital muscular torticollis, stretching has shown efficacy. a protocol of ten sessions of pediatric manual therapy will be applied to infants with positional plagiocephaly in combination with educational physiotherapy. the protocol consists in soft cervical mobilisation, myofascial induction and the application of some pressures to the cranial bones to improve the asymmetry of the head. educational therapy which consists in more "tummy time" stimulation, stimulation to the non preference position of the head and counter positioning. the control group will receive a protocol of stretching at home done by their parents and educational therapy.

Eligibility criteria:
inclusion criteria: * sign of positional plagiocephaly * infants below 12 moths age exclusion criteria: * no neurological disorders * no infectious diseases * no respiratory diseases * no other treatments

Keywords: manual therapy physical therapy cranial asymmetry preferential position of the head
effects of resisted versus balance exercises on cognitive and motor function in patients with mild cognitive impairment

Conditions: Mild Cognitive Impairment

Summary: mild cognitive impairment affects older adults and it includes memory and attentions deficits, and problem-solving difficulties in activities of daily living. resisted exercises is considered a viable strategy to improve balance and motor function in older population. balance exercises comprises proprioceptive, visual and motor learning to a larger degree and has positive effects on memory and spatial cognition and improves balance and motor function. this study aims to determine the effects of resisted and balance exercises on cognition and motor function in patients with mild cognitive impairment.

this randomized clinical trial will be conducted at aziz bhatti shaheed teaching hospital gujrat in seven months after approval of synopsis. the sample size for this trial is 78 patients with mci. the participants will be randomly allocated into two groups using online randomization tool. group a will receive resisted exercises for 30 minutes and group b will receive balance exercises for 30 minutes. participants will receive 3 sessions on alternate days per week for 12 weeks.montreal cognitive assessment (moca) and computerized battery test will be used to assess cognitive impairment, mini-bestest and time up and go test (tug) for balance and motor function.data will be entered and analysed by using spss 26 software.

Eligibility criteria:
inclusion criteria: 1. patients with mild cognitive impairment. (having score between 18 - 24) on moca. 2. participants with both genders will be included . 3. the age limit for the participants will be 60 to 75 years. 4. patients having independence of life (ability to walk independently without any walking aid). exclusion criteria: 1. previous and current history cardiovascular, neurological, psychiatric and motor disorders like (fractures, diagnosis of osteoporosis) 2. patients taking any medication for mild cognition. 3. depressive symptoms, acute and chronic conditions that would preclude exercise, regular exercise (\>30 min/day, \>3days/week). 4. patients having estrogen replacement therapy. 5. simultaneous participation in other studies. 6. regular physical activity (once a week during the last 3 months); physio therapeutic treatment in the last 3 months. 7. diseases that promote incapacity; severe visual deficiency; recurrent vertigo; and uncontrolled systemic arterial hypertension.

Keywords: cognition motor control randomized clinical trial
ticap - titanium clips for appendiceal stump closure

Conditions: Appendicitis

Summary: laparoscopic appendectomy is progressively accepted as the treatment of choice for acute appendicitis. although the surgical technique of laparoscopic appendectomy has been well established, some controversy exists regarding the closure of the appendiceal stump. the available methods for stump closure are currently: pre-knotted loops (roeder loops or endoloop, linear stapler and polymeric clips. a new device is a the ds titanium ligation clip. the design of the ds-clip is characterized by two parallel shanks. the aim of this study is to collect data of a large number of patients treated with the product in real-life clinical routine.


Eligibility criteria:
inclusion: * indication for a laparoscopic appendectomy * informed consent inclusion criteria to be checked intraoperatively: * conventional laparoscopic approach (no sils, notes, spa) * aesculap ds titanium ligation clips were used exclusion: * patient age under 16 years * appendix is severely inflamed with involvement of the caecum

Keywords: laparoscopic appendectomy appendical stump closure
preliminary safety and efficacy study of extracellular vesicle infusion in the intervention of age-related phenotypes with impaired glucose tolerance.

Conditions: Impaired Glucose Tolerance

Summary: the objective of this exploratory study was to evaluate the initial safety of human mesenchymal stem cell-derived extracellular vesicle infusion in an age-related phenotype with impaired glucose tolerance


Eligibility criteria:
inclusion criteria: 1. the subjects are between 35 and 65 years old (inclusive), regardless of gender; 2. the subject's body mass index (bmi) is between 20kg/m2 and 30 kg/m2; 3. the subjects were assessed by the clinical expert group as having abnormal glucose tolerance (ppg 7.8-11.0mmol/l 2h postprandial); 4. subjects voluntarily participate in this clinical study and sign a written informed consent. exclusion criteria: 1. the subject has a severe allergy or is allergic to any component used in cell culture; 2. the subject has used or is using drugs that affect glucose metabolism (such as glucocorticoids, tricyclic antidepressants, etc.) within 1 month; 3. the subjects have chronic diseases such as diabetes and hypertension (very high-risk group) which have not been effectively controlled after treatment; 4. subjects with severe cardiovascular and cerebrovascular diseases: patients with a history of decompensated cardiac insufficiency (nyha grade ⅲ or ⅳ), myocardial infarction or cerebral infarction, or cerebral hemorrhage within 6 months before screening; 5. the subjects had abnormal liver function (alt and/or ast≥ 2.5 times the upper limit of normal), significant abnormal renal function, male serum creatinine ≥1.5mg/dl, female serum creatinine ≥1.4mg/dl; 6, the subject's hiv antibody, hepatitis b surface antigen, hepatitis c antibody, syphilis test positive, hepatitis b virus dna quantitative \> the upper limit of normal test unit; 7. subjects with other serious systemic diseases affecting the study, including malignant tumors, nervous central system, blood system, digestive system, endocrine system, respiratory system, infectious diseases, etc.; (8) drug or alcohol abuse (subjects who consumed \>2 alcoholic beverages per day or \>14 alcoholic beverages per week (one alcoholic beverage is defined as 150ml of wine, 350ml of beer, or 50ml of 80% (40 proof) spirits); or drug abusers; 9. pregnant and lactating women; have a pregnancy plan in the next 2 years (including the spouse's pregnancy plan); refusal to use effective contraception; 10. exclude intracranial lesions and early lung tumors; 11. used stem cell (exosome) therapy or participated in stem cell (exosome) clinical researchers 3 months before screening; clinical investigators who have participated in drugs within 3 months before screening; 12. high risk groups with padua score ≥4 or caprini score ≥5; 13. the subject has a history of major surgery within the past six months or is expected to have surgery within six months; 14. there are other conditions that the researcher considers inappropriate to participate in this clinical study.

Keywords: extracellular vesicle aging human mesenchymal stem cells impaired glucose tolerance
recording for potential af drivers and patient specific atrial anatomy & atrial electrogram maps

Conditions: Atrial Fibrillation

Summary: the 64 pole basket catheter used for the mapping procedure will be defined "atypical" sites which sustain atrial fibrillation. the ablation through the driver will lead to more rapid ablation of the atrial fibrillation.

atrial fibrillation (af) is a common abnormal and rapid heart rhythm characterized by erratic electrical activity of the upper chambers of the heart. this cardiac arrhythmia may lead to stroke, heart failure, low blood pressure, chest pain, and increased mortality rate. treatment may include medication to stop the rhythm abnormality, blood thinners, and/or ablation. ablation involves application of heat or freezing to the area sustaining the rhythm abnormality. this requires tubes (catheters)to be placed in the heart. human atrial fibrillation may be sustained by localized drivers (rapid and/or organized sites of atrial electrical activation). by mapping/recording the patient's specific atrial anatomy and atrial electrical activity with the 64-pole basket catheter, we may add to the knowledge base of these driver locations. we may also add to the knowledge about where best to ablate to terminate the arrhythmia. typical anatomic

Eligibility criteria:
inclusion criteria: * patients at vcu medical center who are 21 years or older undergoing eps for ablation of persistent af (non-rheumatic) whose af episodes last equal to or greater than 7 days but terminate with dc cardioversion or anti-arrhythmic drugs and do not recur within 24 hours. * per current standard of care, af patients must have failed equal to or greater than 1 anti-arrhythmic drug to qualify for ablation. exclusion criteria: * active coronary ischemic in the past year * rheumatic valve disease, that leads to distinct af and increases thromboembolic risk * prior ablation or cardiac surgery, that alters atrial electophysiology * left atrial clot or dense contrast on tee, which would increase thromboembolic risk * out of range serum electrolytes, including k outside 4.0-5.0 mmol/1 * left atrial diameter greater than 60 mm, to exclude extreme structural remodeling and failure to maintain sinus rhythm * thrombotic disease, venous filters, transient ischemic attack or cerebrovascular accident, to minimize additional risk * pregnancy * inability or unwillingness to provide informed consent * unable to converse in english * use of anti-arrhythmic drug less than 5 x half-life prior ablation or cardiac surgery, that alters atrial electophysiology

Keywords: atrial fibrillation cardiac ablation