Kornimate/medical-research-clean huggingface dataset:
efficacy and safety of an infant formula with milkfat and prebiotics

Conditions: Infections; Stool Flora; Stool Biochemistry; Constipation; Food Intolerance

Summary: the purpose of this clinical trial is to evaluate the effect of a new infant starter formula with added prebiotics (gos) and with a fat blend rich in beta-palmitate.

an experimental infant formula with added prebiotics (gos) and with a higher content of palmitic acid esterified in beta-position is to be tested in a double-blinded randomized controlled trial. the addition of prebiotics to an infant formula should favor growth of a beneficial bifidogenic intestinal flora and have positive effects on immunity, promote softer stool formation and short chain fatty acid content in the stools. higher proportion of beta-palmitic acid esterified in 2nd position of the triglyceride should reduce formation of fatty acid-calcium soaps in the stools and promote calcium and fat absorption in the gut, therfor reduce symptoms of constipation and colics.

Eligibility criteria:
inclusion criteria: * healthy term neonates * gestational age 37 to 42 weeks * birth weight 10th to 90th percentile (voigt reference) * infants being exclusively formula-fed at enrollment exclusion criteria: * infants with high risk of atopic disease due to family history * congenital disorder or syndrome with need for special diet / impairment of growth * antibiotic medication prior to enrollment

Keywords: infant formula prebiotics beta-palmitate stool flora bifidogenic
effects of a psychiatric intensive care unit

Conditions: Mental Disorders

Summary: the purpose of the study is to compare the effects of using or not using a psychiatric intensive care unit (picu) in an acute psychiatric department.

the main aim of the study is to compare the effects of using or not using a psychiatric intensive care unit (picu) in an acute psychiatric department.the acute ward of østmarka psychiatric department, st. olavs hospital has a picu separated from the rest of the ward. the picu is separated with a locked door. under two different conditions at different times all patients evaluated to be in need of picu were admitted to the picu. in the first condition the doors inside the picu and between the rest of the acute ward and picu were closed or locked. in the second condition the doors inside the picu and the door between the picu and the rest of the acute ward were either removed or held permanently open. in the second condition the patients thus were admitted to a picu unit not using picu principles. the patients were evaluated with different rating scales at admittance, day three and at discharge from picu.

Eligibility criteria:
inclusion criteria: * all patients admitted to østmarka psychiatric department, st. olavs hospital in need of a picu. exclusion criteria: * patients with dementia or mental retardation to an extensive degree. * patients not speaking norwegian or english.

Keywords: emergency services, psychiatric intensive care units hospitals, psychiatric aggression violence
geriatric assessment and intervention for older patients with frailty in the emergency department

Conditions: Frail Elderly Syndrome; Patient Admission; Hospital Readmission; Length of Stay; Fall; Quality of Life

Summary: comprehensive geriatric assessment (cga) is an established approach for better detection of frailty-related problems and includes individualized treatment plan with multi-discipline supportive and treating measures for the older frailty patients. however, there is limited evidence of feasibility and efficacy of the cga when provided in the emergency department setting. in the gaops-study the efficacy of the cga in emergency department setting will be studied by randomized controlled study protocol. we aim to study if the cga provided in the ed is feasible, safe and efficient method when added with standard emergency care for older frail patients.


Eligibility criteria:
inclusion criteria: * age of minimum 75 years * "clinical frailty scale" minimum 4 estimated at the arrival to the ed by nurse exclusion criteria: * non-resident of the counties (city of espoo, kirkkonummi, kauniainen) of the hospital district.
impact of mothers touch program on women's psychological functioning

Conditions: Psychological Distress; Post Partum Depression; Mood

Summary: the study investigates the effect of the mothers touch program on the psychological well-being of new mothers following 5 weeks of child birth. mothers touch program is designed based on traditional indian post-partum care given by trained carer in the family. study was designed as cohort, including a randomised controlled trial.


Eligibility criteria:
inclusion criteria: * healthy women giving birth for first time (primiparous) * given informed consent * accepts traditional home care exclusion criteria: * previous history of mental health condition * history drug or substance abuse
comparative efficacy of saccadic and biofeedback training in homonymous hemianopia

Conditions: Hemianopia, Homonymous

Summary: this pilot study aims to understand how eye movements change in people with vision loss from stroke after completing one of two types of training. the study will look at how eye movements and reading performance change after training. researchers will compare the results of two groups: one group will complete five clinical training sessions using an eye-tracking machine for 30 minutes each, while the other group will do at-home reading exercises for 20 minutes a day, 5 days a week, for 6 weeks. the goal is to see if there is a difference in performance between the two types of training.


Eligibility criteria:
inclusion criteria: * diagnosis of stroke * presence of hemianopia with central vision involvement * stroke occurred at least 6-months before enrollment exclusion criteria: * presence of hemianopia with macular sparing * diagnosis of hemispatial neglect

Keywords: stroke vision hemianopia
exercise as cardio protective modulates in diabetic patients

Conditions: Diabetes Mellitus; Exercise

Summary: * physical exercise for 6 months produced significant improvement in adiponectin, hs-crp, and nitric oxide (no) and was significantly correlated with adiposity markers, lipid profile and glycemic control factors in both obese and non-obese diabetic patients. * patients with good physical activity reported a significant decrease in bmi, chd risk scores, reduced hs-crp, an increase in the levels of adiponectin and nitric oxide. * in patients with type 2 diabetes mellitus, adiposity markers, lipid profile, hs-crp, and adiponectin were significantly improved following moderate exercise interventions

to elucidate the potential role of exercise as anti-adiposity and anti-cardio protective modulates, we thought to investigate the effect of supervised aerobic training of moderate intensity on adiposity markers, nitric oxide level, plasma adiponectin, hs-crp, and its association with chd risk score in obese and non-obese patients with type 2 diabetes.

Eligibility criteria:
inclusion criteria: * patients with type 2 diabetes for more than 5 years. * patients who were diagnosed according to the criteria of the american diabetes association. * not receiving any drugs affecting the data obtained * had normal daily diets * not participating in any other exercise programs * without any musculoskeletal disorders affecting an exercise program exclusion criteria: * exclusion criteria included anemia, overt complications of diabetes like nephropathy, neuropathy, retinopathy, obvious ischemic heart disease (angina, myocardial infarction, and lead electrocardiogram abnormalities), hcv, hbv, chronic liver and kidney diseases, hypothyroidism, and drugs (diuretics; oral contraceptives).
management of intracerebral hemorrhage with aminocaproic acid - pilot study

Conditions: Intracerebral Hemorrhage

Summary: this is single-arm, open-label, safety and feasibility pilot study of ɛ-aminocaproic acid in ich patients. consecutive ich volume with hematoma volume less than 30 ml by abc/2 method presenting within 3 hours of symptom onset, meeting all inclusion criteria, and without exclusions will be consented and enrolled. subjects will receive 5 grams of intravenous ɛ-aminocaproic acid over 1 hour, followed by the same at 1 mg/hour for 23 hours. comupted tomography (ct) head will be done at 24 hours in order to follow hematoma size. electrocardiogram, lower extremity venous doppler and nihss will also be done at 24 hours. the patient will be followed in the clinic 30-90 days post discharge for functional status.


Eligibility criteria:
inclusion criteria: 1. age 18-80 years 2. supratentorial ich ≤ 30 ml in volume and seen on ≥ 2 slices on a 0.5 mm ct head 3. ivh involving \< 50% of the ipsilateral lateral ventricle will be allowed 4. treatment initiated within 1 hour of baseline ct and 3 hours of onset or last known normal exclusion criteria: 1. baseline mrs ≥ 2 2. infratentorial hemorrhage (brainstem/cerebellum) 3. any supratentorial hemorrhage extending to the brainstem 4. ich \> 30 ml 5. patients who undergo surgical evacuation 6. presenting outside of the 3 hour window 7. intraventricular extension \> 1/2 of one lateral ventricle 8. intraventricular extension into the 3rd or 4th ventricle, or the aqueduct or involving \>50% of the ipsilateral lateral ventricle 9. ich due to trauma 10. ich due to aneurysm of arteriovenous malformation 11. ich due to underlying neoplasm or infectious mass 12. ich due to warfarin or other oral or intravenous anticoagulants 13. international normalization ratio \> 1.4 14. life expectancy \< 1 year (prior to ich onset); due to any cause. 15. history of recent ischemic stroke (within the past 3 months) 16. history of deep vein thrombosis or pulmonary embolism 17. history of recent myocardial infarction (within the past 3 months) 18. known history of hypercoagulable state 19. history of cancer 20. glomerular filtration rate \< 60 ml/min 21. received any hemostatic therapy for any indication (last 14 days) 22. received any investigational therapy in last 90 days 23. "do not resuscitate" order in place or expected, advance directives that could limit aggressive treatment measures.

Keywords: intracerebral hemorrhage stroke cerebrovascular
alveolar management following teeth extraction

Conditions: Alveolar Bone Loss; Bone Resorption

Summary: investigation of the volume stability of the alveolar ridge, the bone structure and soft tissue appearance at a delayed dental implantation using two bone substitute materials (1. human-spongiosa, gefriergetrocknet, chb; 2. collacone®)


Eligibility criteria:
inclusion criteria: * signed informed consent * indication for tooth extraction resulting in a edentulous gap * male and female patients with an age range 20-60 years * caucasian * for female patients: a negative pregnancy test * normotonic blood pressure (according to the who definition): * men: 110/70 - 140/90 mm hg * women: 100/60- 140/90mm hg exclusion criteria: * parallel implantation of another implant * parallel planned prosthetic restoration of the adjacent teeth * smoker (less than 5 years non-smoker) * nursing women * participation in another clinical trial which dates back to less than 3 months before inclusion in this clinical trial * intake of bisphosphonates * radiation therapy (medical history or current) * known diabetes mellitus * inflammatory processes in the mouth (psi\> 2) * presence of autoimmune diseases (rheumatoid arthritis, sjögren's syndrome, systemic lupus erythematosus) * presence of blood coagulation disorders (haemophilia a/b), or the intake of anticoagulants (warfarin, new oral anticoagulants, aspirin\> 100 mg) * osteogenesis imperfecta * osteoporosis * leukemia * agranulocytosis * immunocompromised patients * acute phase and rehabilitation phase of myocardial infarction * oncogenes diseases * patients undergoing chemotherapy * sepsis * acute and chronic infections: sinusitis, rhinitis, pharyngitis and otitis media * wound healing disorders * seizures * gingival hyperplasia * alcohol abuse * drug abuse * infectious diseases (hiv, hepatitis b and c)

Keywords: alveolar bone bone resorption dental implants
use of nitric oxide metabolites for predicting embryo quality in in-vitro fertilization (ivf)

Conditions: Infertility

Summary: improvements in in-vitro fertilization (ivf) outcomes have largely been due to the generation of excess embryos allowing for multiple embryo transfer. unfortunately this has also increased the risk of multiple pregnancy with associated maternal and neonatal morbidity and mortality. the investigators believe that the concentration of nitric oxide metabolites measured in the culture medium from the first day of culture can identify the best quality embryos allowing us to transfer a limited number of embryos without compromising the optimum chance for pregnancy.


Eligibility criteria:
inclusion criteria: * age 21-37 * female * less than two previous unsuccessful ivf cycles exclusion criteria: * day 3 fsh \>9.9 * fewer than 8 mature oocytes retrieved * fewer than 8 normally fertilized embryos on day 2 after fertilization

Keywords: infertility assisted reproductive technology nitric oxide
arch size study for anatomical variations

Conditions: Aortic Arch; Aneurysm; Dissection, Aortic

Summary: the aortic arch with a common origin of the innominate and left carotid artery (cilca) prevalence in the general population is 13.6%. its reputation as a benign anatomical variant has been ultimately shattered by further studies that identified the cilca arch as a potential marker for thoracic aortic disease (tad) the aim of this work is to report the ct anatomical characteristics of the aortic arch in subjects with or without aneurysms requiring treatment, in 5 major european cardiovascular centers.


Eligibility criteria:
inclusion criteria: all patients with aortic arch ct scan at investigating centers exclusion criteria: none

Keywords: aortic arch bovine arch thoracic aortic disease
predict mde outcomes after mst

Conditions: Major Depressive Episode

Summary: this trial attempts to explore the treatment outcome of magnetic seizure therapy (mst) for major depressive episode. half of the participants will receive mst, while the other half will receive electroconvulsive therapy (ect).

magnetic seizure therapy (mst) is likely to be an alternative options to electroconvulsive therapy (ect). widespread stimulation of cortical and subcortical regions is inevitable for ect since the substantial impedance of the scalp and skull shuts most of the electrical stimulus away from the brain. nevertheless, magnetic pulses are capable to focus the stimulus to a specific area of the brain because they can pass the scalp and skull without resistance. in addition, electric current will penetrate into deeper structures, while magnetic stimulus are only capable to reach a depth of a few centimeters. as a consequence, mst are able to generate focus stimuli on superficial regions of the cortex while ect can't, which may give mst the capability to produce comparable therapeutic benefits with the absence of apparent cognitive side effects.

Eligibility criteria:
inclusion criteria: 1. dsm-5 diagnosis of major depressive episode; 2. convulsive therapy clinically indicated, such as severe psychomotor excitement or retardation, attempts of suicide, being highly aggressive, pharmacotherapy intolerance, and ineffectiveness of antipsychotics; 3. the hamd-17 ≥ 24; 4. informed consent in written form. exclusion criteria: 1. primary diagnosis of other mental disorders; 2. severe physical diseases, such as stroke, heart failure, liver failure, neoplasm, and immune deficiency; 3. present with a laboratory abnormality that could impact on efficacy of treatments or safety of participants; 4. failure to respond to an adequate trial of ect lifetime; 5. are pregnant or intend to get pregnant during the study; 6. unremovable metal implants. 7. other conditions that investigators consider to be inappropriate to participate in this trial.
a randomized trial of rosuvastatin in elective angioplasty to prevent contrast-induced nephropathy (clear-cin).

Conditions: Nephropathy

Summary: the investigators analyzed the hmg-coa reductase inhibitor, rosuvastatin, for the prevention of contrast-medium-induced nephropathy in patients undergoing primary angioplasty.

patients with stable coronary artery disease already taking chronic statin undergoing elective angioplasty are at risk for contrast-medium-induced nephropathy because there are specified risk factors as age more than 75 years, chronic renal insufficiency, diabetes, use of contrast and the lack of effective prophylaxis.

Eligibility criteria:
inclusion criteria: * chronic statin use * positive stress test findings (electrocardiography, nuclear imaging, or stress echocardiography * elective angioplasty. exclusion criteria: * non-statin therapy * any presentation of acs within 24 hours before the time of randomization * current use of potent cyp3a4 inhibitors, including azole antifungals, protease inhibitors, macrolide antibiotics, and cyclosporine * renal replacement therapy, a history of kidney transplant, pregnant and with renal failure (serum creatinine \> 3.0 mg/dl).

Keywords: contrast,nephropathy, angioplasty, stable coronary
shield study: using naso-oropharyngeal antiseptic decolonization to reduce covid-19 viral shedding

Conditions: COVID-19; SARS-CoV 2

Summary: essential workers in positions with increased likelihood of exposure to sars-coc-2 will be most impacted by the proposed project. evidence has shown that the sars-cov-2 novel coronavirus is easily transmissable through close contact between individuals, especially during aerosol-generating procedures such as intubation of patients. the intervention proposed in this study (nasal and oral decontamination with povidone-iodine and chlorhexidine, respectively) presents an opportunity for a safe, effective, and feasible treatment to decontaminate the primary entry points for sars-cov-2. as such, the intervention to be studied in this project may protect healthcare and other essential workers by preventing transmission of sars-cov-2 from patients to healthcare workers, as well as the general public to essential worker,. and thus reducing the incidence of covid-19 in these workers.


Eligibility criteria:
inclusion criteria: * participant is a essential worker performing at least some in-person job duties (not 100% remote) * participant is willing and able to perform intervention and data collection procedures. * participant is able to provide informed consent in english language. exclusion criteria: * diagnosis of covid-19 within 2 months prior to enrollment, or active respiratory illness symptoms at time of enrollment * known medical contraindication to chlorhexidine gluconate or povidone-iodine treatment ingredients (such as a known allergy) * participant has a known medical and/or surgical reason prohibiting nasal swab sampling. * participant is female who is pregnant, or believes she may be pregnant, at time of enrollment. * participant is actively taking/using any treatments or interventions as part of any other covid-19 related investigational trials.

Keywords: covid-19 povidone-iodine chlorhexidine gluconate transmission virology
local anesthetic nebulization and instillation for pain control after laparoscopic surgery

Conditions: Laparoscopic Cholecystectomy

Summary: studies evaluating intraperitoneal local anesthetic instillation for pain relief after laparoscopic procedures have provided conflicting results. this randomized, double-blind study was designed to assess the effects of a novel intraperitoneal local anesthetic administration technique using nebulization on pain relief after laparoscopic cholecystectomy.

studies evaluating intraperitoneal local anesthetic (la) instillation for pain relief after laparoscopic cholecystectomy have provided conflicting results. one of the factors that might contribute to failure of the instillation technique may be related to inadequate distribution of local anesthetic throughout the peritoneal surface. in contrast, nebulization should provide a uniform spread of drugs throughout the peritoneal cavity and thus may be beneficial to improve pain relief after laparoscopic procedures. a recent study reported that bupivacaine nebulization significantly reduced pain after laparoscopic cholecystectomy compared with bupivacaine instillation in the gallbladder bed. however, these investigators used a custom-made nebulization system that needs a separate gas source and tubing that is cumbersome and may not be easily available. recently, the investigators reported that a microvibration-based nebulization device (aeroneb pro® system, aerogen, galway, ireland) could be used for ropivacaine delivery into the insufflation gas required to create pneumorpeitoneum. the investigators hypothesized that intraperitoneal ropivacaine nebulization would provide superior pain relief after laparoscopic cholecystectomy than intraperitoneal ropivacaine instillation. this randomized, double blind, controlled clinical trial was designed to assess the analgesic efficacy of ropivacaine nebulization using the aeroneb pro® device laparoscopic cholecystectomy compared with intraperitoneal ropivacaine instillation.

Eligibility criteria:
inclusion criteria: * asa score i-iii * scheduled for laparoscopic cholecystectomy * free from pain in preoperative period * not using analgesic drugs before surgery * without cognitive impairment or mental retardation * written informed consent exclusion criteria: * emergency/urgency surgery * postoperative admission in an intensive care unit * cognitive impairment or mental retardation * progressive degenerative diseases of the cns * seizures or chronic therapy with antiepileptic drugs * severe hepatic or renal impairment * pregnancy or lactation * allergy to one of the specific drugs under study * acute infection or inflammatory chronic disease * alcohol or drug addiction

Keywords: laparoscopic cholecystectomy nebulization ropivacaine