Kornimate/medical-research-clean huggingface dataset:
web-based communication education for breast cancer survivorship care

Conditions: Breast Cancer

Summary: this two-phase research plan will develop and test a culturally relevant, web-based patient education program, hereafter known as e-talkcare. the intervention aims to empower chinese cancer patients to effectively communicate with different providers in different healthcare settings.

this two-phase study develops and tests the usability and efficacy of a culturally relevant, web-based patient education program, hereafter known as e-talkcare, in improving chinese immigrant breast cancer survivors' competence, perceived control, and self-efficacy in cancer care communication (intermediate outcomes), and patient-reported symptoms, adherence to breast cancer survivorship care guidelines, and quality of life (distal outcomes) versus the usual care control arm. in phase i, community-based participatory research (cbpr) principles will be used to develop the intervention to educate participants about culture and communication by demonstrating how to ask for and verify information with doctors and use personalized symptom reports, and by providing question prompt lists for doctor visits. in phase ii, the intervention will be tested in a pilot randomized control trial (rct). using cases from los angeles cancer surveillance program, california cancer registry, maryland cancer registry, and clinics from california, 118 chinese immigrant women (diagnosed with stage 0-iii breast cancer and 1-3 years post-diagnosis) will be enrolled and randomized to either the e-talkcare intervention or a usual care control arm. participants will be interviewed via telephone at baseline (i.e., pre-randomization), 3-, and 6-months post-randomization.

Eligibility criteria:
inclusion criteria: eligible chinese women * ≥ age 18 * foreign-born speaking mandarin and/or cantonese, * diagnosed with breast cancer at stage 0, i, ii or iii, * 1-3 years post-diagnosis and completed primary treatment (surgery, radiation, and chemotherapy); and * no recurrence, and 6) internet access. exclusion criteria: * women with other cancer types are ineligible due to different treatment complications.

Keywords: chinese american women provider-patient communication survivorship care
milking the umbilical cord versus immediate clamping in pre-term infants < 33 weeks

Conditions: Prematurity

Summary: anemia in preterm neonates is a significant problem encountered frequently in the neonatal intensive care unit. most preterm neonates born at less than 33 weeks gestation will require at least one blood transfusion during their hospital course and many will require repeated transfusions. blood transfusions, albeit necessary, carry increased risk of viral infections and transfusion reactions as well as increase the cost of healthcare. the umbilical cord and placenta harbor up to 40% of blood available during fetal life. the current standard of care is immediate umbilical cord clamping. the investigators are performing a randomized controlled trial comparing immediate cord clamping to milking the umbilical cord prior to clamping in neonate born preterm less than 33 weeks gestation. the investigators hypothesize that milking the umbilical cord will demonstrate the same benefits as delayed cord clamping, without delaying neonatal resuscitation.


Eligibility criteria:
inclusion criteria: * preterm neonates delivered between 24 0/7 and 32 6/7 * mother carrying a fetus between 24-32 6/7 weeks estimated gestational age * written parental consent exclusion criteria: * multiple gestation pregnancies (twins or higher order multiples) * rh or other antibody sensitization * hydrops fetalis * known major congenital abnormality * suspected abruptio placentae

Keywords: neonate umbilical cord cord milking prematurity
cardiovascular disease progression and prognosis in covid-19

Conditions: Covid19

Summary: the cvp-covid19 registry is both a retrospective and prospective study design in order to identify predictors of cardiovascular disease progression and mortality for covid-19. the registry enrolls consecutive patients with positive microbiological tests for sars-cov-2 admitted to an academic hospital in northern italy for worsening of covid-19 symptoms. the study does not test any new diagnostic or therapeutic approach. patients are treated according to good clinical practice. patients characteristics, including medical history (with particular attention to cardiovascular and pneumological risk factors), features of physical examination, results laboratory and radiological tests and treatments (pre- and in-hospital) are related with patient outcome. logistic analysis (univariate, multivariate and propensity) are performed in order to identify factors associated with disease progression. primary endpoint: mortality.

members of the steering committee: olivia manfrini (università di bologna, italy) raffaele bugiardini (università di bologna, italy) stefano nava (università di bologna, italy) elisabetta poluzzi (università di bologna, italy) maria carla re (università di bologna, italy) caterina vocale (policlinico sant'orsola) study coordinator: edina cenko (università di bologna, italy)

Eligibility criteria:
inclusion criteria: hospitalization for covid-19 exclusion criteria: age \<18 years

Keywords: cardiovascular diseases pneumonia, viral sars-cov-2 covid-12 ace receptor
achromobacter spp: description of epidemiology and resistance in chronic ear infections and in healthy individuals.

Conditions: Achromobacter; Epidemiology; Chronic Ear Infection

Summary: hearing loss can be the result of chronic ear infections. the role of bacteria of the genus achromobacter is not known in these conditions. an epidemiological study including a large number of patients is needed to compare the prevalence of these bacteria in sick and healthy subjects, and to highlight the characteristics of the strains and the factors favouring their emergence.


Eligibility criteria:
inclusion criteria: * person or parent who has given his or her non-opposition * person over 10 years of age * sick subjects group : diagnosis of chronic infection by an ent specialist doctor if patient already included: new episode \> 3 months after the complete clinical recovery from the previous episode observed by the ent doctor - healthy group: no ear infection in the last 6 months and no antibiotics in the previous month. exclusion criteria: -
effects of wolffia globosa (mankai) in patients undergoing bariatric surgery.

Conditions: Bariatric Surgery Candidate; Diet Modification

Summary: candidates to bariatric surgery at the bariatric and metabolic institute at cleveland clinic florida are prescribed a high protein liquid diet for two weeks preoperatively and 2 weeks postoperatively. whether wolffia globosa (mankai), a plant based wholesome food, can serve as a natural alternative to liquid diet during the 2 week pre-operation and 2 weeks postoperation liquid based diet, is unknown. the investigators aim to address the effect of daily wolffia globosa (mankai) administration on morbid/severely-obese patients during the 2 week pre-operative period and 2 weeks postoperatively as compared to iso protein-iso caloric shake source on the following parameters

this study is a prospective study involving patients selected for elective surgery. patients undergoing bariatric surgery will be enrolled in this study and have several parameters checked as explained below. patients selected and consented for elective bariatric surgery will be recruited in the bariatric and metabolic institute to participate in this study and will undergo standard of care. the investigators will enroll approximately 120 candidates during a 6 months (\~5 a week) period. patients will be randomized to the a. control group: 3 traditional shakes or b. intervention group: 2 traditional shakes and 1 daily administration of substituting iso-protein green wolffia globosa (mankai) shake (4 frozen cubes of wolffia globosa (mankai) equal to 20 grams of dry wolffia globosa (mankai). each shake will provide equivalent carbohydrate, calories and protein levels from the respective source. as part of our routine pre and postoperative screening and follow up protocol, the investigators will collect anthropometric and clinical data on all patients, including standard of care blood samples collected at 2 weeks pre operatively, surgery day and at 2 months postoperatively

Eligibility criteria:
inclusion criteria: • patients that will undergo sleeve gastrectomy. exclusion criteria: * age below 18 years * american society of anesthesiologist (asa) class iv or v * patients using vitamin-k antagonists * patients with documented coagulopathies.

Keywords: bariatric surgery sleeve gastrectomy preoperative diet hepatic steatosis wolffia globosa hyperglycemia
effect of two different plane blocks on post-thoracotomy pain

Conditions: Pain, Postoperative; Thoracotomy; Erector Spinae Plane Block; Serratus Anterior Plane Block

Summary: thoracotomy is recognized as one of the most painful surgical procedures. this increases the frequency of postoperative pulmonary complications. erector spinae plane block (espb) and serratus anterior plane block (sapb) are more superficial, easier to perform, and less likely to have complications. in addition, espb and sapb applications are increasing in patients who underwent thoracotomy and thoracoscopic surgery. in this study, the investigators aimed to evaluate the effect of continuous espb and continuous sapb via us-guidance on post-thoracotomy pain.


Eligibility criteria:
inclusion criteria: * 18 to 65 years old * asa physical status i-ii-iii * bmi 18 to 30 kg/m2 * elective thoracotomy surgery exclusion criteria: * patient refusing the procedure * emergency surgery * history of chronic opioid or analgesic used

Keywords: pain, postoperative thoracotomy erector spinae plane block serratus anterior plane block
effect of ll-bfre training on volitional muscle activation in subjects with knee joint impairment

Conditions: Arthrogenic Muscle Inhibition; Knee Injuries; Knee Surgery

Summary: the aim of this study was to investigate whether 4 weeks of exercise training against low mechanical resistance in combination with partial blood flow restriction has an additional therapeutic effect on the patients\&#39; ability to activate the knee extensor muscle. patients with chronic deficits in muscle strength due to knee injuries or surgery on one leg were invited to participate in this study on a completely voluntary basis.

the effects of low-load exercise with blood flow restriction (bfr) on the ability to voluntarily activate skeletal muscle in people with joint injuries are poorly understood. the aim of our study was to investigate the effects of low-load bfr training on the level of voluntary activation (al) of the quadriceps femoris muscle assessed using the interpolated twitch technique in people with different knee joint injuries. thirty-three orthopedic patients assigned to either the bfr group or the sham-bfr group participated in the study. over a period of four weeks, the participants completed 12 training sessions of unilateral knee extension and leg press at 30 rm. the bfr group trained with a pneumatic cuff-induced blood flow restriction (pressure = 120-140 mmhg), while the sham-bfr group trained with a sham blood flow restriction (pressure = 20 mmhg) that did not interfere with normal muscle perfusion. the assessment of knee muscle capacity and function consisted of dynamometric measurements of maximal isometric strength and endurance of the knee extensor muscles, level of voluntary muscle activation, surface electromiography, pain intensity and assessment of perceived exertion. all tests and measurements were performed twice, once before the intervention (baseline) and once at the end of the 4-week training period (post).

Eligibility criteria:
inclusion criteria: * no systemic illness, * no history of injuries to the contralateral knee, * pain intensity during exercise ≤ 2 on numeric pain rating scale (0-10). exclusion criteria: * neuromuscular impairments, * spine or other lower limb injuries, * presence or history of any vascular diseases or deep vein thrombosis * pain intensity during exercise ≥ 3 on numeric pain rating scale (0-10).

Keywords: arthrogenic muscle inhibition knee injury level of volunaty muscle activation blood flow restriction resistance exercise controlled clinical trial
impact of high mechanical index ultrasound impulses on left ventricular stroke volume with intravenous microbubbles

Conditions: Cardiac Disease

Summary: this study will investigate whether applying high mechanical index (mi) impulses from a diagnostic ultrasound transducer when using ultrasound enhancing agent (uea) microbubble infusion will result in subclinical improvement in left ventricle systolic function.

the purpose of this study is to investigate whether applying high mi impulses from a diagnostic ultrasound transducer when using ultrasound enhancing agent(uea) microbubble infusion will result in subclinical improvement in lv systolic function detected by left ventricular outflow tract velocity time integral (lvot vti).

Eligibility criteria:
inclusion criteria: age 19 years or older exclusion criteria: 1. severe aortic valve stenosis 2. pregnant or lactating women 3. atrial fibrillation 4. very poor image quality despite contrast use. 5. unstable cardiac condition such as cardiogenic shock. 6. allergy to uea 7. presence of right to left or bidirectional shunts. 8. patients on mechanical circulatory support.
hydroxychloroquine vs. azithromycin for hospitalized patients with suspected or confirmed covid-19

Conditions: COVID-19

Summary: this study will compare two drugs (hydroxychloroquine and azithromycin) to see if hydroxychloroquine is better than azithromycin in treating hospitalized patients with suspected or confirmed covid-19.


Eligibility criteria:
inclusion criteria: * adult (age ≥ 18 years) * confirmed or suspected covid-19, * confirmed: positive assay for covid-19 within the last 10 days * suspected: pending assay for covid-19 with high clinical suspicion * scheduled for admission or already admitted to an inpatient bed exclusion criteria: * allergy to hydroxychloroquine or azithromycin * history of bone marrow transplant * known g6pd deficiency * chronic hemodialysis or glomerular filtration rate \< 20ml/min * psoriasis * porphyria * concomitant use of digitalis, flecainide, amiodarone, procainamide, propafenone, cimetidine, dofetilide, phenobarbital, phenytoin, or sotalol * known history of long qt syndrome * current known qtc\>500 msec * pregnant or nursing * prisoner * weight \< 35kg * seizure disorder * severe liver disease * outpatient use of hydroxychloroquine for treatment of a disease other than covid-19 or has received more than 2 days of hydroxychloroquine or azithromycin for suspected or confirmed covid-19 * patient has recovered from covid-19 and/or is being discharged from the hospital on day of enrollment. * treating physician refuses to allow patient participation in the study * unable to obtain informed consent * prior enrollment in this study

Keywords: sars-cov-2 hydroxychloroquine azithromycin
cryoablation for phantom limb pain

Conditions: Phantom Limb Syndrome

Summary: the purpose of this study is to determine if treatment with percutaneous cryoablation yields significant differences in the evaluative criteria of phantom limb syndrome (pls).

this study aims to treat phantom limb syndrome (pls) with cryoablation of the remaining nerve stumps. the rationale is that because the pain in pls follows the known distribution of nerves, and because the amputated nerves are known to undergo changes after the surgery that may lead to excessive "firing," that interruption of the nerve impulses will reduce patient pain.

Eligibility criteria:
inclusion criteria: * subjects are status post (s/p) amputation of an upper or lower limb. that is, the amputation is not congenital. * refractory pain symptoms, following tissue healing(postoperatively, or post injury) are related to amputation as determined by referring physician and investigator, to include: stump pain, phantom pain, unpleasant phantom sensations, and/or undesirable and/or life-limiting kinesthetic sensations. the character, frequency, location, description, and exacerbation or relieving elements will be recorded. patients will be questioned as to the location of their sensation, be it pain, movement, burning, tingling, or other. the location of their pain will be correlated with the corresponding proximal nerve stump. * positive anesthetic/steroid block, as performed under ct guidance in an analogous fashion to the cryoablation procedure. * absence of infection * absence of coagulopathy * ability and willingness of patient to provide written informed consent exclusion criteria: * active infection * underlying congenital segmentation or other spinal anomalies that result in differential nerve root pressures * significant spinal stenosis interpreted as "severe" on any cross sectional imaging study * pregnant or planning to become pregnant * immunosuppression * history or laboratory results indicative of any significant cardiac, endocrine, hematologic, hepatic, immunologic, infectious, metabolic, urologic, pulmonary, gastrointestinal, dermatologic, psychiatric, renal, neoplastic, or other disorder that in the opinion of the principal investigator would preclude the safe performance of cryoablation. * uncorrectable coagulopathies * concurrent participation in another investigational trial involving systemic administration of agents or within the previous 30 days. * have undergone a previous surgical intervention - post amputation - that may have altered the target nerve.
a 4 week study to investigate the safety and tolerability of azd5069 in patients with moderate to severe chronic obstructive pulmonary disease (copd)

Conditions: Scientific Terminology Chronic Obstructive Pulmonary Disease (COPD); Laymen Terminology Chronic Bronchitis and Emphysema

Summary: the purpose of this study is the evaluate the safety and tolerability of azd5069 in patients with chronic obstructive pulmonary disease


Eligibility criteria:
inclusion criteria: * clinical diagnosis of copd with symptoms for more than one year before screening * body mass index of 18-30 kg/m2 and weight of 50-100kg * current or ex-smokers with a smoking history of at least 10 pack years (1 pack year = tobacco consumption corresponding to 20 cigarettes smoked per day for one year) at screening * fev1 of 30% or above and less than 80% of the predicted normal value post-bronchodilator at screening * fev1/fvc less than 70% post-bronchodilator at screening exclusion criteria: * any clinically significant disease or disorder * exacerbation of copd which was not resolved within 30 days of first dosing * patients who have received live or live-attenuated vaccine in the 2 weeks prior to first dosing * asthma and any current respiratory tract disorder other than copd which is considered to be clinically significant * disease history suggesting reduced or abnormal immune function other than that related to copd

Keywords: chronic obstructive pulmonary disease, neutrophil, respiratory disease
cognitive function after radiation therapy for primary brain tumours

Conditions: Primary Brain Tumour; Radiation Toxicity; Cognitive Impairment

Summary: this study will assess cognitive function in patients with a primary brain tumour treated with radiation therapy (rt) to generate radio-sensitivity and volume effect parameters for the development of cognitive dysfunction. all types of brain tumours apart from glioblastoma will be included.

rt is fundamental in the treatment of primary brain tumours. rt contributes to improved local control and prolonged progression-free survival in patients with a broad range of tumour types. irradiation to the normal brain may lead to cognitive impairments. clarifying the nature and severity of impairment in adult rt-treated brain tumour patients, including region-specific effects, are important for optimal utilization of novel conformal rt technologies such as proton therapy. the study is a prospective nationwide study including approximately 300 brain tumour patients from the danish center of particle therapy and the four neuro oncology centers in denmark. the patients will be assessed with a comprehensive battery of standardized cognitive tests and complete a questionnaire (pro's). they will do this prior to rt treatment and 1, 3, 5 and 10 years afterwards. the pro's includes measures on quality of life, fatigue, sleep, depression, anxiety, and socio demographics. the standardized tests are: trail making test (tmt); hopkins verbal learning test (hvlt); controlled oral word association test (cowat) - animals and s; coding and digit span from wais-iv. the correlation between cognitive scores and rt dose-volume parameters to specific areas in the brain will be tested. this study will elucidate the dose-response relationship in radiation-induced damage to substructures of the brain such as hippocampus, thalamus, temporal and frontal lobes that will allow the clinician to prioritize these structures in planning of proton radiotherapy.

Eligibility criteria:
inclusion criteria: * 18 years or older and danish speaking. * performance status who 0-2 * capable of cooperating on testing * tumour histology (who 2016 classification) of the following types: anaplastic astrocytoma (idh mutant), diffuse astrocytoma (idh-mutant), gemistocytic astrocytoma (idh mutant), diffuse astrocytoma (nos), oligodendroglioma, meningioma, medulloblastoma (nos), pituitary adenoma, other brain tumours including skull base sarcomas exclusion criteria: * glioblastoma * performance status 3-4 (karnofsky performances of 60 or less)

Keywords: brain tumour radiation therapy cognitive function hippocampus patient reported outcomes
use of diagnostic measures in chronic obstructive pulmonary disease (copd) in routine practice and their impact on treatment decisions

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: this study will evaluate the diagnostic measures (including blood eosinophil counts) commonly used by lung specialist's in routine clinical care of subjects with copd in germany and how these diagnostic tests influence the physician's treatment decisions. the study will be conducted in three parts. in the first part, lung specialist's, who will not participate in the survey, will develop doctor's questionnaire. the second part is an interventional cross-sectional study, wherein approximately 30 lung specialists will be enrolled and data on their perspective on diagnosis and treatment of copd subjects will be collected via the revised doctor's questionnaire. the third part is a retrospective non-interventional study where each doctor will collect retrospective data from selected subjects with copd from the time of informed consent up to 12 months before. the retrospective data will be collected from subject files of approximately 250 subjects with copd.


Eligibility criteria:
inclusion criteria: for participating centers (sample 1: 30 lung specialists from germany) * more than 10 years of experience in respiratory medicine * at least 500 subjects under supervision in hospital- or office-based setting: a) focus on obstructive lung diseases. b) board certification. c) informed consent to participate in this study and to share files of consenting subjects. for subjects (sample 2: 250 copd subjects from these 30 doctors from sample 1) * written informed consent to use his/her data. * age \>=40 years * pack years \>10, current or former smoking * duration of copd: \>=1 year since copd diagnosis record in subject files (also confirmed by spirometry) * no concurrent asthma diagnosis * at least one year of documented disease history at participating study doctors and have to be under the care of the before mentioned physician during this time because of copd. exclusion criteria: * subjects who are pregnant and breastfeeding (in the last 12 months) * subjects currently participating in any interventional study * subjects with severe comorbidities which would have influence on the copd therapy

Keywords: blood eosinophil count copd diagnostic test doctor's questionnaire lung specialist