Kornimate/medical-research-clean huggingface dataset:
feeling and body investigators

Conditions: Functional Abdominal Pain

Summary: this study will provide tools to develop and pilot an intervention for functional abdominal pain (fap) using a ten session intervention with children ages 5-8. investigators will train the subjects to be "feeling and body investigators". during treatment phases the following will occur 1) gather clues (learn), 2) investigate (experience: perform interoceptive mystery missions to explore a body sensation), 3) organize body clues (contextualize: recall other contexts that evoke similar sensations), and 4) go on increasingly daring missions (challenge: decrease avoidance and safety behaviors). the fbi intervention will be developed and refined in 26 child-caregiver dyads during the current r21 phase. in the r33 phase investigators will randomize 100 subjects with fap to fbi or an active control group in order to conduct a pilot-test of the feasibility, acceptance, and clinical significance of fbi. young children with fap who complete the fbi early intervention will learn to experience changes in the viscera as fun and fascinating, rather than scary, and will develop new capacities for pain management, adaptive functioning, and emotion regulation. for the r21 phase (assessing initial feasibility) investigators hypothesize that ≥ 80% of participants enrolled in fbi will complete treatment and that ≥ 80% of participants will complete home-based practice assignments.


Eligibility criteria:
inclusion criteria: * child is between 60 and 107 months old. * parent/legal guardian is present at the clinic visit who speaks english * child screens positive for recurrent abdominal pain by having: 1) 8 episodes of abdominal pain over 2 months (based on rome iii criteria), or 2) 2 or more episodes of abdominal pain which are causing an incapacity greater than or equal to 25% of the time in the past two months). * based on pediatric medical assessment, child meets criteria for functional abdominal pain (fap) based on absence of other organic causes of recurrent abdominal pain. * consent given by caregiver and assent by child to participate. * presence of internet access, including that accessed by cell phone with video capabilities. exclusion criteria: * the index child being known to have mental retardation (iq \< 70) or other pervasive developmental disorders. * subject has a sibling who is already enrolled in our study. \*\*\*possible exclusion\*\*\* * parent/ guardian who would be participating in the study is pregnant.

Keywords: functional abdominal pain, children finding a treatment or intervention for children
a trial to assess the long-term safety and efficacy of lacosamide in subjects with painful diabetic neuropathy

Conditions: Painful Diabetic Neuropathy

Summary: the purpose of this study is to determine if lacosamide (spm 927) is safe if taken for a longer period of time and whether it continues to work well to treat pain. subjects will receive lacosamide at a dose that will be individually determined to be the one that provides most pain relief with the least side effects. the maximum dose will be 600mg/day. subjects may participate in this trial until october 2007. this time may be extended to allow them to participate until lacosamide is commercially available. if a subject meet the requirements for the study at visit 1 and after a two weeks phase without trial medication, s/he enters a titration phase to determine the personal optimal dose of lacosamide. when this dose is reached s/he will enter the maintenance phase and will be asked to return for visits every 4 weeks for the first 24 weeks and every 12 weeks thereafter.


Eligibility criteria:
inclusion criteria: inclusion criteria: * painful diabetic neuropathy exclusion criteria: * no clinically relevant liver enzyme abnormalities and impaired renal function, no cardiac abnormalities, no pregnant or nursing females exclusion criteria:

Keywords: painful diabetic neuropathy lacosamide
single session combined locoregional therapies for hepatocellular carcinoma

Conditions: Liver Cancer

Summary: hepatocellular carcinoma is the third most common cause of cancer-related mortality. in recent years, transarterial chemoembolization, radio frequency ablation and microwave ablation have been accepted as treatment modalities for patients with surgically unresectable hepatocellular carcinoma.

to compare between combination treatment with radiofrequency or microwave ablation followed by transarterial chemoembolization and performed in a single session.

Eligibility criteria:
inclusion criteria: * child classification a or b. * serum albumin ≥ 3 gm/l. * serum bilirubin \< 2.5 mg/dl. * platelet count ≥70,000 mm3. * inr ≤ 1.6. * serum creatinine \< 2 mg/dl. * tumor size more than 4 cm and confined to one lobe of the liver. exclusion criteria: * patients with portal vein thrombosis. * a technically inaccessible hepatic artery. * metastatic hcc. * more than three lesions. * lesions in close proximity to the portal vein (pv),inferior vena cava (ivc) or gall bladder were excluded from the study.
paracetamol and ibuprofen/indomethacin in closing patent ductus arteriosus

Conditions: Patent Ductus Arteriosus

Summary: the purpose of this pilot trial is to study efficacy and safety of simultaneous intravenous (iv) ibuprofen/indomethacin and paracetamol medications in the closure of patent ductus arteriosus (pda) in preterm infants. it is randomized, placebo-controlled, double-blind, phase 1, multicenter, clinical trial.

premature infants (born before 37 weeks gestational age) with patent ductus arteriosus (pda) are the focus of the study since no trials on the additive efficacy of these two medications on the contraction of ductus arteriosus are available. preterm infants who are diagnosed to have a hemodynamically significant pda and who, according to the decision of the attending clinician, need ibuprofen/indomethacin therapy, are eligible to this trial. if the parents deny the consent, the patient will be treated according to the standard pda treatment: three days' iv ibuprofen pedea® 5mg/ml solution infusion (oulu, helsinki, tartu) dosing: 10mg/kg + 5mg/kg + 5mg/kg (q24h); or three days' iv indomethacin (turku) 0.2mg/kg + 0.1mg/kg + 0.1mg/kg (q24h). in case of any contraindications for ibuprofen/indomethacin, the treatment would be surgical ligation.

Eligibility criteria:
inclusion criteria: * preterm infants (born before 37+0 gestation weeks) who are diagnosed to have a hemodynamically significant pda and who, according to the decision of the attending clinician, need ibuprofen therapy, are eligible to this trial. exclusion criteria: * severe malformation or suspected chromosomal defect * other very severe life-threatening disease (e.g. very severe birth asphyxia or persistent pulmonary hypertension, etc.)

Keywords: acetaminophen ibuprofen preterm infant near infra-red spectroscopy indomethacin
use of 31p mrs to assess brain nad+ in healthy current and former collegiate athletes

Conditions: Concussion, Mild

Summary: can nicotinamide riboside (750 mg/day for 12 weeks) affect the levels of nad+ in the brain as measured by 31p mrs?

healthy collegiate athletes (football, soccer, rugby, hockey, and volleyball) will take nicotinamide riboside (nr) or placebo twice daily for 84 days. pre- and post-intervention evaluations include physical assessment, blood tests for safety and toxicity monitoring, blood tests for biomarkers, neurologic testing, quality of life questionnaires, and the 31p mri exam.

Eligibility criteria:
inclusion criteria: * adult current and former (within 2 years) collegiate athletes (football, rugby, soccer, hockey, and volleyball) * body mass index (estimated based on height and weight) from 23 to 37 * willing to provide informed consent, ingest test substance, and provide blood specimens * willing to comply with study instructions and maintain current level of physical activity throughout the study exclusion criteria: * history of loss of consciousness of more than 5 minutes * contraindications to magnetic resonance imaging (mri), such as implanted medical devices, metal objects, or pacemakers * history of epilepsy * history of more than 3 concussions * history of headache preceding a concussion * history of depression preceding a concussion * history of developmental delays or attention deficit hyperactivity disorder (adhd) * history of post-traumatic seizures * history of complex spine and/or skull trauma

Keywords: brain nicotinamide adenine dinucleotide (nad+) adenosine triphosphate (atp) depletion polyadenosine diphosphate-ribosepolymerase (parp) activation
effect of lower limb exproprioception training in virtual environment on locomotion performance in stroke patients

Conditions: Spatial Perception; Stroke; Virtual Reality; Exercise Training; Exproprioception

Summary: the purpose of this study is to determine if a virtual reality training of foot placement with or without visual cues about the location of the foot in the environment would improve locomotion-related function in persons in the chronic stage of stroke. participants were randomly assigned to receive twice per week, for a total of 2 weeks' training with visual cues (control group) or without (experimental group). it was hypothesized that the experimental group would be able to place the foot closer to the target when stepping and have more symmetrical gait. so far, 22 stroke patients completed the experiment. preliminary results support the hypothesis. this project is still ongoing.


Eligibility criteria:
inclusion criteria: * first time unilateral stroke and onset over 6 months * able to independent walking with or without aids over 10 meters * mini-mental state examination (mmse) score above 24 * orientation intake, able to identify right and left * normal or corrected-to-normal vision, able to see the 2 cm diameter circle on the floor while standing exclusion criteria: * gait nearly normal * had other neurological and musculoskeletal disease which can affect walking ability * hemineglect * use virtual reality device will severely discomfort, such as headaches, blurred vision, vertigo or vomiting
pre-hospital cerebral oxygenation and end-tidal co2 during cardiopulmonary resuscitation (cpr)

Conditions: out-of Hospital Cardiac Arrest

Summary: cerebral saturation will be measured pre-hospital during an out-of hospital cardiac arrest with o3tm regional oximetry for root® (masimo®). the o3tm regional oximetry for root® (masimo®) is a device that can measure not only cerebral saturation but also end-tidal co2 (capnography). currently, end-tidal co2 is already measured during advanced life support following most recent european resuscitation guidelines but with another monitor. until now it is the only parameter which may predict return of spontaneous circulation. because of this, researchers want to measure both with the same device, which gives the investigators the opportunity and advantage to compare end-tidal co2 and cerebral saturation very precisely. in this manner researchers want to investigate the predictive value of cerebral saturation and compare it end-tidal co2.


Eligibility criteria:
inclusion criteria: * all consecutive ohca patients exclusion criteria: * dnr code * no possibility to attach cerebral oxygenation sensor

Keywords: cerebral saturation capnography pre-hospital
prevention of de novo hcv with antiviral hcv therapy post-liver and post-kidney transplant

Conditions: Hepatitis C; Transplantation Disease Transmission

Summary: in this study, subjects that do not have hepatitis c virus (hcv) will be transplanted with livers or kidneys from donors who do have hcv. medications that are used to treat hcv will be given to the study subjects shortly after transplant to protect them from developing the problems hcv can cause to the liver.


Eligibility criteria:
inclusion criteria: * adult (≥ 18 year-old), wait-listed for primary kidney or liver transplant without a potential suitable living donor or for simultaneous liver kidney transplant; * hcv non-infected at the time of transplant. subjects who were previously hcv infected but who have had documented svr12 are eligible to participate; * agree to use two methods of birth control during the study; * donor characteristics: serum hcv nat-positive and negative for hepatitis b surface antigen. for liver transplant: pre-donation liver biopsy with no fibrosis (f0) or minimal fibrosis (f1). for kidney transplant: kidney donor profile index \< 85%. exclusion criteria: * donor and/or recipient hiv infection * subject pregnant or nursing * donor and/or recipient hepatitis b surface antigen positive * kidney-pancreas transplant * single organ liver recipients who received hemodialysis for more than 7 days prior to liver transplantation * kidney recipients: on dialysis for \> 5 years at time of screening; subjects sensitized with panel reactive antibody \> 80%; for single organ kidney transplant, subjects with advanced liver fibrosis (knodell stage 3) or cirrhosis * individuals being treated with and needing to continue rifabutin, rifampin, carbamazepine, phenytoin, phenobarbital, oxcarbazepine, st. john's wort (hypericum perforatum), medium- or high-dose rosuvastatin or atorvastatin, or high-dose proton pump inhibitors (see concomitant medications). * individuals treated with amiodarone within 42 days of organ transplant.
the effects of neuromuscular electrical stimulation on swallowing functions in stroke patients with dysphagia

Conditions: Stroke; Swallowing Disorder; Dysphagia; Stroke, Complication; Cerebrovascular Accident

Summary: in our study, our aim is to evaluate the effect of neuromuscular electrical stimulation added to traditional dysphagia therapy in stroke patients with dysphagia, on functional oral intake status, dysphagia-related symptoms, quality of life, and complications related to dysphagia.


Eligibility criteria:
inclusion criteria: * after the first week after a stroke, detecting dysphagia by using bedside water assessment test * lesion location is shown by mri or ct * unsupported sitting balance * the score of mini-mental state examination test (mmse) 20 and above * over 18 years old exclusion criteria: * global aphasia or cognitive disorders that may affect the understanding of the instructions * patients with major medical problems that may affect participation * tracheostomy presence * previous neck surgery * to have received radiotherapy in the head or neck area * presence of a cardiac pacemaker or a history of epilepsy

Keywords: stroke swallowing disorder dysphagia stroke rehabilitation neuromuscular electrical stimulation traditional dysphagia therapy
the effect of continuous management of suction cuff pressure and subglottic irrigation suction on preventing valri study

Conditions: Ventilation Acquired Pneumonia

Summary: assessing the effectiveness of continuous cuff pressure management combined with subglottic suction irrigation in reducing ventilator-associated lower respiratory tract infections (valrti) in mechanically ventilated patients at high risk of aspiration.


Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years; 2. undergoing endotracheal intubation or tracheostomy; 3. expected duration of mechanical ventilation exceeding 72 hours; 4. presence of one or more high-risk factors for reflux/aspiration: recurrent laryngeal nerve injury, cerebral infarction/cerebral hemorrhage (new or pre-existing swallowing dysfunction), cranial surgery/traumatic brain injury (tbi), neuromuscular junction disorders (e.g., myasthenia gravis, muscular dystrophy, parkinson's disease, or other conditions that weaken swallowing muscle strength and coordination), continuous use of muscle relaxants for ≥ 48 hours during mechanical ventilation, icu-acquired myopathy, icu-acquired weakness, gastroparesis (gastric residual volume \> 500 ml/6 hours), or impaired consciousness; 5. voluntary participation in the study by the subject or their legal representative, with signed informed consent. exclusion criteria: 1. expected duration of mechanical ventilation less than 48 hours; 2. pregnant or breastfeeding women; 3. patients with tracheoesophageal or bronchopleural fistula; 4. difficult intubation (more than three attempts) or patients with reflux/aspiration during intubation (with lung injury and secondary pulmonary infection); 5. patients with irreversible disease, end-stage conditions, or those expected to die in the near future; 6. patients already diagnosed with ventilator-associated pneumonia (vap), i.e., excluding hospital-acquired pneumonia; 7. patients participating in other clinical trials that are expected to influence the results of this study; 8. patients deemed unsuitable for inclusion in the study by the investigator.
rapid extremity pain relief by battlefield acupuncture after orthopedic surgery

Conditions: Pain

Summary: the purpose of this study is to determine if the addition of battlefield auricular acupuncture (bfa) to standard therapy causes reduction in pain, medication use, time to ambulation without assistance, hours missed from work and increases quality of life after lower extremity surgery at two air force medical centers.

we will recruit 429subjects into this research study, for an expected 309 completing the study. we estimate 120 subjects will either withdraw consent or become ineligible for the study. subjects will be ≥18 years or older and scheduled for lower extremity surgery. to randomize subjects, we will employ a random number generator, which will minimize difference between study groups. additionally, we will collect data about patients' length of hospital stay, which will allow for statistical control of the variable, complexity of surgical procedure. the research assistants/coordinators will be responsible for obtaining informed consent and hipaa authorization from subjects, collecting data, and de-identifying data prior to review and analysis by the investigators. the investigators will be responsible for ongoing protocol monitoring, insertion of needles, verifying inclusion/exclusion criteria, and analyzing data.

Eligibility criteria:
this study is being conducted at a military installation. you must have military insurance in order to participate in this study. inclusion criteria: male and female subjects (dod beneficiaries), 18 years or older who are scheduled for lower extremity surgery below the hip. exclusion criteria: pregnant or breastfeeding absence of their ear active cellulitis of their ear ear anatomy precluding identification of acupuncture landmarks non-english speaking use of hearing aids that preclude the insertion of asp needles inability to comply with study protocol
exploring effectiveness and mechanism of change of an implementation strategy on guideline implementation in schools

Conditions: Mental Disorder; Stress

Summary: this project is a two-armed randomized-controlled trial exploring the effectiveness and mechanisms of change of two different implementation strategies for implementing the guideline for the prevention of mental ill-health at the workplace. the project will be conducted among public primary and secondary schools belonging to four municipalities in sweden. data will be collected with mixed-methods at baseline and different time-points of follow-up.

there is an urgent need for more knowledge on effective implementation strategies, as two-thirds of implementation efforts fail to achieve the intended change, and half have no effect on outcomes of interest. these implementation failures are partly due to the limited understanding of how implementation strategies work-the mechanisms of change through which implementation strategies affect implementation. this project will fill this research-gap by exploring mechanism of change during a cluster randomized controlled trial that compares the effectiveness of two implementation strategies for implementing the guideline for the prevention of mental ill-health at the workplace in schools. schools are chosen as the setting for implementation given the high prevalence of mental ill-health among teachers. moreover, schools lack a structured approach to the prevention of mental ill-health. the aim of the project is to investigate how implementation strategies affect the defined mechanisms and guideline implementation. mechanisms that will be tested include hypothesized mediators originating from the individual behavior change theory com-b. the project will be conducted in public primary and secondary schools in four municipalities in sweden. data will be collected with mixed-methods from school-management and personnel at baseline, and different time-points during follow-up.

Eligibility criteria:
inclusion criteria: * all personnel employed by the school exclusion criteria: * personnel not employed by the school (e.g. cleaning- and canteen-personnel)

Keywords: guideline implementation implementation strategies mechanism of change workplaces organisational and social work environment schools
does dry needling affect treatment outcomes of interlaminar epidural steroid injection in cervical disc herniation?

Conditions: Pain, Myofacial; Pain, Neck; Pain, Chronic

Summary: chronic neck pain is among the most frequently seen chronic painful conditions. as an important cause of disability, chronic neck pain is a musculoskeletal disorder that negatively affects quality of life. cervical disc herniation is one of the leading causes of chronic neck pain and conservative methods such as exercise and pain medications are used first in the treatment. in patients unresponsive to conservative treatment, epidural steroid injection is successfully and frequently used treatment option. epidural steroid injection in the cervical region can be applied with two approaches: interlaminar or transforaminal. myofascial trigger point characterized by intramuscular taut band and hypersensitive spots is a condition in which central and peripheral sensitization play a role in the pathophysiology. there are underlying myofascial trigger points in many etiologies that cause chronic neck pain. trigger points can increase the severity of pain and in some cases they can be the main factor in the etiology of pain. therefore, the presence of myofascial trigger points should be investigated, even if another cause is detected in chronic neck pain. dry needling is an easily applicable and effective treatment option in myofascial trigger point. although it is well known that myofascial trigger points frequently accompany cervical disc herniation, their effect on treatment outcomes has not been investigated. in this study, we aimed to investigate the effect of dry needling for trigger points on the treatment results of interlaminar epidural steroid injection in patients diagnosed with cervical disc herniation.


Eligibility criteria:
inclusion criteria: * between the ages of 18-65 * chronic neck pain due to cervical disc herniation for at least 3 months and being unresponsive to conservative treatment * presence of at least one active myofascial trigger point on physical examination of cervical paraspinal muscles, scapulothoracic muscles and extremity muscles. exclusion criteria: * previous surgical/interventional procedure for the cervical region * previous application of dry needling/acupuncture to any part of the body * presence of other musculoskeletal disorders (such as lateral epicondylitis, tendinitis, entrapment neuropathy) that may cause diagnostic confusion in terms of pain pattern and localization * signs of trauma, fracture, malignancy, or active infection * rheumatological (ra, as, etc.), endocrinological (such as osteoporosis, paget's disease) or another systemic disease that may change the anatomical or physiological structure of the relevant regions * presence of coagulopathy * history of whiplash injury, cervical spinal stenosis, cervical spondylosis * have a diagnosis of fibromyalgia * being pregnant and breastfeeding * presence of mental deterioration or psychiatric/neurological disease that can affect flow of the study.

Keywords: myofascial trigger point pain disc, herniated epidural injections