Kornimate/medical-research-clean huggingface dataset:
pediatric bronchoscopy and lus

Conditions: Atelectasis; Atelectasis, Postoperative Pulmonary

Summary: rigid bronchoscopy is commonly used for diagnosing and treating lung and airway diseases, including foreign body removal. patients often experience atelectasis post-procedure, which lung ultrasound (lus) can effectively detect. lus is a rapid, noninvasive imaging technique that provides real-time evaluation without the need for patient transportation. in this observational study, researchers will assess the incidence and severity of atelectasis in patients undergoing elective rigid bronchoscopy, comparing those who were intubated and awakened post-procedure with those who were not intubated. the study aims to determine whether intubation influences the development of atelectasis after bronchoscopy.

rigid bronchoscopy has been used for many years in the diagnosis and treatment of various primary diseases of the lungs and airways, removal of tracheobronchial foreign bodies and therapeutic procedures for central airway pathologies. most patients have atelectasis after the procedure. lung ultrasound (lus) has begun to take its place in clinical use as a new tool for the detection of both acute and chronical pathologies in the perioperative period and intensive care follow-up of patients. its use is rapid, noninvasive, point-of-care, without radiation and no need patient transportation. the imaging pattern of atelectasis is similar to that of lung consolidation, and the b line image and loss of lung shear are considered typical findings. atelectasis after a bronchoscopy procedure can be recognized with lus. as standard procedure, after bronchoscopy, patients are given drugs (neostigmine or sugammadex) to reverse the effect of muscle relaxants and are allowed to wake up. during this time, patients are sometimes intubated until their respiratory function is fully restored and the patient wakes up. which patient is intubated depends on factors such as the patient's comorbidities, lung capacity, the procedure performed and the clinician's preference. intubation may reduce the development of atelectasis due to positive airway pressure. in this observational study, we aim to determine the frequency and degree of atelectasis in patients undergoing elective rigid bronchoscopy using lung ultrasound. specifically, we will compare the frequency and degree of atelectasis in patients who were intubated and awakened after bronchoscopy and those who were awakened without intubation.

Eligibility criteria:
inclusion criteria: * elective rigid bronchoscopy * american society of anaesthesiologists (asa) physical status i or ii exclusion criteria: * emergent rigid bronchoscopy * asa iii or above * patients left intubated after the procedure
azacytidine plus chidamide in the treatment of relapsed and refractory angioimmunoblastic t-cell lymphoma

Conditions: Angioimmunoblastic T-cell Lymphoma

Summary: this is a multicenter prospective single arm phase ii study. the purpose of this study is to evaluate the safety and efficiency of azacytidine combined with chidamide in the treatment of relapsed/refractory angioimmunoblastic t-cell lymphoma.

azacytidine was given subcutaneously at a dose of 75 mg/m2 on days 1-7. chidamide was an oral tablet which was administered 20mg twice weekly. this regimen was repeated every 28 days. treatment was given until disease progression, unacceptable toxicity, or patient/investigator discretion.

Eligibility criteria:
inclusion criteria: * pathologically confirmed angioimmunoblastic t-cell lymphoma according world health organization (who) classification; * age≥18years; * ecog≤2; * patients received at least one systemic treatment previously and achieved no remission or relapsed after first-line treatment; * adequate bone marrow hematopoietic function: anc\>1.5 × 109/l，hgb\>90g/l，plt\>80 × 109/l; * adequate organ function: alt≤3 times uln, tbil≤1.5 times uln, scr≥50ml/min/m2, cardiac function grade 0-2 (nyha); exclusion criteria: * active or uncontrolled infections requiring systemic treatment within 14 days before enrollment; * any instability of systemic disease, including but not limited to severe cardiac, liver, kidney, or metabolic disease need therapy; * pregnant or lactating women;

Keywords: angioimmunoblastic t-cell lymphoma azacytidine chidamide
evaluation of dry eye symptoms in cae with application of intranasal neurostimulation

Conditions: Dry Eye Syndromes

Summary: this study evaluates the safety and effectiveness of the intranasal tear neurostimulator applied intranasally (active) compared with the same device applied extranasally (control) relating to symptoms of dry eye exacerbated by the controlled adverse environment model.

participants will be randomized to a single application sequence, either sequence "a" (intranasal application followed by control application) or sequence "b" (control application followed by intranasal application) using the device. upon entering the cae, participants will complete dry eye questionnaires every five minutes and will administer the device either intranasally or extranasally in randomized sequence when a certain level of ocular discomfort has been reached.

Eligibility criteria:
inclusion criteria: * moderate to severe dry eye disease * normal lid/lash anatomy, blinking function and closure as determined by the investigator * literate, able to speak english, and able to complete questionnaires independently exclusion criteria: * chronic or recurrent epistaxis, coagulation disorders or other conditions that, in the opinion of the investigator, may lead to risk of clinically significant increased bleeding * nasal or sinus surgery (including history of application of nasal cautery) or significant trauma to these areas * implanted metallic or electronic device in the head, a cardiac demand pacemaker, or an implanted defibrillator * corneal transplant in either or both eyes * a woman who is pregnant, nursing an infant, or planning a pregnancy at the screening visit * be currently enrolled in an investigational drug or device study or have used an investigational drug or device within 30 days prior to the screening visit
comparison of nexfin pulse contour analysis and cardiac magnetic resonance imaging for the measurement of cardiac output

Conditions: Cardiac Diseases

Summary: a growing interest in monitoring cardiac output (co) non-invasively has emerged, however its determination has been difficult using the standard approaches. the aim of the study is to evaluate the accuracy and precision of pulse contour analysis (pca) as compared to cardiac magnetic resonance imaging (cmr).


Eligibility criteria:
inclusion criteria: * indication for cmr exclusion criteria: * contraindication for cmr * claustrophobia * no consent obtained
effect of propolis nanoparticles on postoperative pain and bacterial reduction in mandibular premolars

Conditions: Necrotic Pulp

Summary: the aim of this study is to clinically compare the intensity of post-operative pain and the amount of bacterial reduction after using 20mg/ml propolis nanoparticles extract solution during chemo-mechanical preparation, versus 2.5% naocl, in asymptomatic necrotic mandibular premolars treated in a single visit.


Eligibility criteria:
inclusion criteria: 1. systematically healthy patient (asa i,ii). 2. age between 20 and 55 years 3. male or female. 4. asymptomatic mandibular premolar teeth diagnosed with pulp necrosis with or without apical periodontitis. 5. radiographic examination using digora intraoral periapical sensor plate and software (digora; soredex, helsinki, finland) showing mandibular premolars with (smaller than 3 mm (0-2 mm)) periapical radiolucency. exclusion criteria: 1. medically compromised patients having significant systemic disorders. (asa iii or iv). 2. history of intolerance to nsaids. 3. teeth with: * immature roots * vital pulp tissues. * association with swelling. * acute peri-apical abscess or acute exacerbation of a chronic abscess. * mobility grade ii or iii. * previously accessed or endodontically treated * deep periodontal pockets more than 4 mm * vertical root fractures, coronal perforation, calcification, and external or internal root resorptions. 4. patients who could not interpret the nrs. 5. patients with diabetes, immune-compromising, and immunosuppression disease and pregnant women were, also, excluded.
minimally invasive knee replacement outcomes (mikro) study

Conditions: Knee Osteoarthritis

Summary: the purpose of this study is to evaluate and compare the clinical, radiographic (x-ray) and cost effectiveness outcomes (cost relative to risks and benefits) of two different minimally invasive knee joint replacement surgical techniques. the primary study hypothesis is that in comparing total knee replacement performed with the two different surgical techniques that respect four minimally invasive surgery principles (low-profile instrumentation, "minimally invasive" incision, overall minimal knee surgical intervention), a faster return to function will result when the technique does not incise the tendon.

this study does not include financial compensation for treatments involved.

Eligibility criteria:
inclusion criteria: * presence of severely symptomatic knee osteoarthritis that has failed non- operative treatment * males and non-pregnant females, 35-85 years of age at the time of surgery * asa class 1 or 2 * procedure will not require computer navigation * patient/surgeon has not requested another implant * patient has signed an irb approved study consent form * patient is able and willing to actively participate in post-operative rehabilitation program * patient understands study requirements * patient is willing to comply with follow-up visits and diary documentations * patient is capable of independent ambulation exclusion criteria: * skeletal immaturity * more than 10 degrees of valgus or varus deformity as measured from a weight bearing ap alignment view * patients with bilateral knee osteoarthritis who are considering a simultaneous bilateral procedure * bone or ligament insufficiency that requires the use of augments or stems, or constrained component * daily pre-operative use of narcotic pain medication * prior knee arthroplasty * patient is a prisoner * patient has had prior tibial tubercle osteotomy * patient's surgical knee would require removal of hardware prior to tka * patient has \< 95 degrees flexion pre-operatively

Keywords: total knee arthroplasty minimally invasive knee replacement knee osteoarthritis cost effectiveness minimally invasive knee surgery
post-hospital case management to improve clinical outcomes in individuals requiring mechanical ventilation

Conditions: Acute Respiratory Distress Syndrome

Summary: king county lung injury project: survivor outcome study (kclip:sos) is a randomized trial for individuals who have survived prolonged mechanical ventilation (5 days or more). the objective is to enroll individuals who are likely to have impaired health status resulting from prolonged critical illness but whose long term prognosis is good. such individuals are most likely to benefit from the study intervention of case management targeted at post intensive care complications. kclip:sos will test whether an outpatient intervention based on a nurse using a targeted case management tool can reduce patient morbidity and improve quality of life in the 6 months following hospital discharge. this intervention will be compared to usual post-hospital care.

background: the purpose of this study is to understand individuals' physical and emotional conditions and concerns after being ventilated in the hospital. modern hospital care helps many people survive even if they are on ventilators for long periods of time. some individuals who leave the hospital after this kind of intensive care suffer from depression, post-traumatic stress disorder, muscle weakness, tiredness or breathing difficulties that may decrease their quality of life. doctors know little about finding and treating these problems in survivors of mechanical ventilation. design narrative: participants will be randomly assigned in blocks of 10 (5 participants to usual care and 5 participants to case management) for home or skilled nursing facility discharges. the outcome assessors (the interviewers collecting outcomes data) will be blinded to group assignment. primary outcome: all participants will have a baseline interview soon after hospital discharge and a final interview at the end of the 6-month intervention period (outcome assessments). all subjects will be asked to keep a diary/journal of their medical appointments, health services, and medications. participants will be called once a month to collect this information. key secondary outcomes: case management participants will be contacted by the nurse case manager who will provide follow-up care for 6 months. at the end of the study, interview results will be sent to the personal physician of the usual care participants so that appropriate care can follow.

Eligibility criteria:
inclusion criteria: * on a ventilator for 5 or more days * expected to survive the 6 months post-hospital discharge period * lives in the sos zip code area (king, pierce and snohomish counties) exclusion criteria: * severe pre-hospital health conditions * lack of availability for follow-up (e.g. homeless, chronic substance abuse) * non-english speakers * severe psychiatric issues * need for special rehabilitation services not available in the intervention * predicted survival of less than 6 months
food intake and appetite in the children of mothers with diabetes

Conditions: Diabetes

Summary: this protocol is for study of the effect of inhibition of parasympathetic outflow on insulin secretion and glucose metabolism. insulin secretion will be measured during infusions of escalating doses of atropine. other clinical parameters of parasympathetic inhibition by atropine will also be assessed.

children of mothers who had diabetes during pregnancy are at an increased risk of diabetes and obesity in later life, effects partly mediated by the early environment experienced by the offspring of diabetic mothers in utero. in this protocol, we address why intra-uterine exposure to maternal diabetes might lead to later childhood obesity. previous studies of children of diabetic mothers have not detected any alteration in energy expenditure, either as resting metabolic rate or physical activity. we will now examine whether they are at an increased risk of obesity due to differences in food intake. we will assess composition of the diet, patterns of eating, taste preference and physiological responses to a mixed meal. no previous work in human subjects has addressed these issues.

Eligibility criteria:
* inclusion criteria: group 1: offspring of mothers with diabetes during pregnancy. maternal diagnosis of type 2 diabetes (by who criteria after a 75g ogtt or on clinical grounds with at least one random plasma glucose greater than 200mg/dl) before or during the index pregnancy. group 2: offspring of mothers with diabetes diagnosed following pregnancy. maternal diagnosis of type 2 diabetes (by who criteria after a 75g ogtt or on clinical grounds with at least one random plasma glucose greater than 200 mg/dl) after the index pregnancy. it is important to also ensure that these mothers did not have any major disturbance in glucose tolerance during the index pregnancy and a record of normal glucose tolerance after the index pregnancy; therefore they will only be included if there are also: adequate records of glucose testing during the index pregnancy and these records are not in keeping with a diagnosis of gestational diabetes (by either who criteria if a 75g oral glucose tolerance test has been carried out). at least one non-diabetic ogtt after the index pregnancy. exclusion criteria: 1. history of weight loss for child (greater than 2kg over last 6 months). 2. presence of other major illnesses which might interfere with appetite or food intake in mother or child. 3. child not living with mother.

Keywords: obesity etiology macronutrient selection taste preference mixed meal test
disparities in emergency contraceptive metabolism dictate efficacy

Conditions: Contraceptive Usage

Summary: the purpose of this study is to learn more about why some people are at greater risk for oral emergency contraceptive failure while others are not. the investigators want to learn if genetic differences impact the risk of emergency contraception failure.

each of us can respond differently to a drug or medication based on our genetics. an emergency contraceptive, ulipristal acetate or upa, normally works by stopping or delaying the ovary from releasing an egg (ovulation). our bodies break down upa in order to use it through a system call the cytochrome p450 pathway but this pathway can be faster or slower depending on our genetics. the investigators want to learn more about how our individual genetic differences in this pathway change how the ovary responds to upa. the overall goal of this research is to improve the effectiveness of emergency contraception for all people.

Eligibility criteria:
inclusion criteria: * generally healthy women * aged 18-40 * regular menses (every 21-35 days) experiencing ovulatory cycles proven by a single progesterone level of 3 ng/ml or greater during the luteal phase of the screening cycle. exclusion criteria: * pregnant, seeking pregnancy, or breastfeeding * known allergy to study medication * recent use of hormonal contraception * irregular periods (\ 35 day cycles) * routine use of nonsteroidal anti-inflammatory drugs * metabolic disorders * smoking * any condition that would preclude the provision of informed consent * using drugs (within 2 weeks of study enrollment) known to interfere with the metabolism of upa as well as drugs known to be cyp3a4 inducers, inhibitors, or cyp3a drug substrates

Keywords: ulipristal acetate emergency contraception
efficacy of the quell wearable device for chronic low back pain

Conditions: Low Back Pain

Summary: this is a 1-year trial designed to gather information about the use of the quell for persons with chronic musculoskeletal low back pain.

research objectives: this is a 1-year trial designed to gather information about the use of the quell for persons with chronic musculoskeletal low back pain. the investigators hypothesize that those assigned to using the device will report reduced back pain compared with those in the control condition; with those using the device also showing improvement in sleep, mood, and level of activity. the investigators hypothesize that frequency of using the quell (increased tolerability and adherence) will be correlated with greater reduction in pain. the investigators hypothesize that the device will be safe to use and will demonstrate a reduction in healthcare utilization (reduced clinic and emergency department visits). finally, based on preliminary analyses limited by few subject numbers, the investigators will investigate whether certain individuals report greater benefit from using the quell than others and, in particular, would predict that those with more intense and longer duration of pain will demonstrate most benefit.

Eligibility criteria:
inclusion criteria: * all participants will be adults age 21 or older and diagnosed with axial musculoskeletal back pain without radiculopathy. * patients will be invited to participate if they own a smart phone (iphone or android device) and are able to download the pain app and the quell relief program app onto their device. * patients will also be included if they: 1. have chronic pain for \> 3 months' duration 2. average 4 or greater on a pain intensity scale of 0 to 10 3. are able to speak and understand english. exclusion criteria: * patients will be excluded from participation if they meet any of the following criteria: 1. diagnosis of cancer or any other malignant disease 2. acute osteomyelitis or acute bone disease 3. present or past diagnostic and statistical manual-v diagnosis of schizophrenia, delusional disorder, psychotic disorder, or dissociative disorder that would be judged to interfere with study participation 4. pregnancy 5. any clinically unstable systemic illness judged to interfere with treatment 6. a pain condition requiring urgent surgery 7. an active substance use disorder, such as cocaine or iv heroin use, (positive on the mini international neuropsychiatric interview; m.i.n.i. v.5.0) that would interfere with study participation 8. any prescription opioid use for pain 9. have an implanted cardiac pacemaker, defibrillator, or other implanted device. all subjects will be asked to not change their treatment during the study period.
the link between the clinical resting heart rate and sympathetic overactivation

Conditions: Cardiovascular Disease

Summary: it is a retrospective study with no products limitation to investigate the link between clinical resting hr and soa. use hr≤60bpm as control group, compare other three groups with the control group and find out the correlation between hr and soa indexes.


Eligibility criteria:
inclusion criteria: 1. provision of subject informed written or oral consent 2. female and male aged≥ 20 to ≤ 80 years; 3. records on mean clinical heart rate and soa indexes were available. exclusion criteria: 1. participation in another clinical study with an investigational product during the last 6 months; 2. drug intervention on heart rate 1 month prior to the inclusion; 3. patients with missing data in the database from the shanghai institute of hypertension, ruijin hospital, shanghai.
changes in everydaylife activity of children with cp during habit-ile

Conditions: Cerebral Palsy

Summary: studying in a rct the changes in everyday llife activities of children with cp during habit-ile or control period, changes being scored by parents and by experts.

studying in a rct the changes in everyday llife activities of children with cp (unilateral and bilateral) during habit-ile or control period, changes being scored by parents and by experts on abilhand-kids, the pedi, the activlm-cp and the copm. investigate neuroplastic changes and correlation with everyday life changes.

Eligibility criteria:
inclusion criteria: * cerebral palsy * ability to make a few steps with a walking device * ability to pick a light object from a table with the more affected hand * ability to understand simple games exclusion criteria: * no active seizure * no botulinum toxin in the 6 months previous to the intervention or during intervention time * major visual deficit

Keywords: motor skill learning functional changes neuroplastic changes