Kornimate/medical-research-clean huggingface dataset:
effects of ashtanga-vinyasa yoga supta on portuguese airforce military pilots performance

Conditions: Military Operational Stress Reaction

Summary: a total of 18 military pilots in their tirocinium in the air force academy from the portuguese air force course "masters in military aeronautics: aviator pilot specialist" participated in this study. participants were randomly assigned to yoga (intervention group) or waiting list (control group). procedures were approved by the évora university research ethics committee and participants will give written informed consent according to the helsinki declaration (approval number: 21050).

a randomized, prospective, controlled trial was designed, with the participants (n=18) randomly distributed into two groups. the control group (n=8) will be receiving the protocolized classes from the course "masters in military aeronautics: aviator pilot specialist" for 12 weeks, the intervention group (n=10) will receive the same course and 2 sessions per week (1h each) of the yoga classes (4). the intensity of the program (borg rating of perceived exertion scale) will be measured. the operative performance response measurements will be collected at baseline and post-intervention. participants will complete the following emergency protocols in a flight simulator: (1) take-off engine failure, (2) flight engine failure close to the base, (3) flight engine failure far away from the base, and (4) alternator failure. this intervention protocol was accepted by the portuguese airforce to be applied on airbase 11 in beja.

Eligibility criteria:
inclusion criteria: * healthy military pilots in their tirocinium in the air force academy from the portuguese air force course "masters in military aeronautics: aviator pilot specialist exclusion criteria: * military pilots on active duty before or after the tirocinium; * injured military pilots; * military pilots on sudden lifestyle changes (as in: starting or quitting smoking habits; starting or quitting any kind of medication; starting a new diet)

Keywords: yoga airforce pilots operational performance military pilots
soft tissue augmentation around immediate implants in the esthetic zone

Conditions: Recession, Gingival

Summary: following tooth loss, a considerable reduction in hard- and soft-tissue volume can be expected (tan wl, et al., 2012), (araujomg, et al., 2015). in the anterior maxilla, tissue loss can make future implant restorations more challenging and less predictable in terms of achieving and maintaining favorable soft-tissue-emergence profiles. even with careful implant planning and placement, marginal gingival recession of 0.5-1 mm has been a common finding with single-tooth implants (nisapakultorn k, et al., 2010), (suphanantachat s, et al., 2012). this is partly attributed to bone remodeling after implant surgery, and occurs regardless of implant-placement protocol used (hof m, et al., 2015).

the dome technique addresses the placement of the ct, as it is layered over the implant and takes the shape of an inverted dome. the advantage of the dome ct technique is that it allows for both buccal and coronal augmentation of local soft tissue, while maximizing blood supply to the area by using tunneling-technique principles. it enhances and augments the peri-implant tissue foundation for a favorable facial and interproximal restorative emergence profile. as this technique does not involve raising an independent buccal flap, the gingival tissue of the adjacent teeth is not compromised, and thus the risk of recession and formation of black triangles on the adjacent teeth is minimized.

Eligibility criteria:
inclusion criteria: * patients with healthy systemic condition * patients aged from 20 to 45 years old availability of bone apical and palatal to the socket to provide primary stability. * presence of adequate gingival architecture with the surrounding dentition * patient provides an informed consent * adequate inter-arch space for implant placement * favorable occlusion (no traumatic occlusion) * good oral hygiene * accepts 6-month follow-up period exclusion criteria: * patients with signs of acute infection related to the area of interest * patients with habits that may jeopardize the implant longevity and affect the results of the study such as para-functional habits * current and former smokers * pregnant females * hiv or hepatitis; 5/physical handicaps that would interfere with the ability to perform adequate oral hygiene * alcoholism or chronic drug abuse; 7/ heavy smokers \>10/cigarettes per day
assessment of biomarkers in pregnancy on unknown location and ectopic pregnancy

Conditions: Pregnancy of Unknown Location; Ectopic Pregnancy; Early Pregnancy; Early Pregnancy Loss

Summary: to further develop the patient care pathway for women classified with a pregnancy of unknown location (pul) and ectopic pregnancy (ep).

purpose and design-there is a need for the patient care pathway to evolve in order to aid and improve the diagnosis and management of women with a pregnancy of unknown location (pul) and ectopic pregnancy (ep). there is potential for this to be achieved by the incorporation of a statistical model that uses one or more novel markers identified by this study. recruitment-1000 patients. inclusion: patients attending the early pregnancy unit (epu) in the first trimester with a pul or ectopic pregnancy on trans-vaginal ultrasound scan between the ages of 18-50 years. exclusion: patients diagnosed with cancer, presence of acute medical condition, patients aged less than 18 years, patients who cannot give fully informed study consent. consent - posters will advertise the study. patients in epu will be invited to the study by a member of the clinical care team. written consent will be required. confidentiality - the chief investigator will preserve the confidentiality of participants taking part in the study and is registered under the data protection act. patient consent forms will be stored securely within the study file. all patient identifiable information, where required, will be stored electronically on national health service (nhs) approved computers, accessible only by personnel involved in the study via password. conflict of interest - none involved in the study have a conflict of interest. dissemination of results - no patient identifiable information will be included in the research report or publication. anonymised results will be disseminated to scientific community by means of publication in peer-reviewed literature and presented at national and international meetings.

Eligibility criteria:
inclusion criteria: * patients attending the early pregnancy unit in the first trimester of pregnancy (≤14 weeks gestation) aged between 18-50 years old and categorized as having a pul or ectopic pregnancy exclusion criteria: * younger than 18 years of age * women who in the opinion of the researcher by virtue of language or learning impairment would be unable to give fully informed consent to the study * viable intrauterine pregnancy (the presence of a fetal pole with a fetal heartbeat within the uterine cavity) * miscarriage * presence of an acute medical condition
a phase 1 dose escalation study of vx-973 in healthy participants

Conditions: Pain

Summary: the purpose of the study is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple doses of vx-973 in healthy participants.

this clinical trial information was submitted voluntarily under the applicable law and, therefore, certain submission deadlines may not apply. (that is, clinical trial information for this applicable clinical trial was submitted under section 402(j)(4)(a) of the public health service act and 42 cfr 11.60 and is not subject to the deadlines established by sections 402(j)(2) and (3) of the public health service act or 42 cfr 11.24 and 11.44.).

Eligibility criteria:
key inclusion criteria: * body mass index (bmi) of 18.0 to 32.0 kilogram per meter square (kg/m\^2) * a total body weight of more than (\>) 50 kg * participants of non-childbearing potential * nonsmoker or ex-smoker for at least 3 months before screening key exclusion criteria: * history of febrile illness or other acute illness that has not fully resolved within 14 days before the first dose of study drug * any condition possibly affecting drug absorption, distribution, metabolism, or excretion other protocol defined inclusion/exclusion criteria may apply.
gated radiotherapy in left sided breast cancer patients

Conditions: Breast Neoplasm Female; Radiotherapy Side Effect; Heart Diseases

Summary: to assess the need of respiratory gated radiotherapy in left sided breast cancer patients.


Eligibility criteria:
inclusion criteria: * left sided breast cancer patients treated with breast conserving surgery exclusion criteria: * patients treated with mastectomy * patients with positive lymph nodes
long-term clinical feasibility of the new indwelling provox vega 20 voice prosthesis

Conditions: Total Laryngectomy

Summary: the purpose of this study is to investigate long-term clinical feasibility of a new voice prosthesis and insertion system provox vega 20 with smartinserter) for voice rehabilitation after total laryngectomy. outcome measures are voice quality, ease of insertion, device life, and reason for replacement.


Eligibility criteria:
inclusion criteria: * total laryngectomy * use provox2 voice prosthesis * at least two prior prosthesis changes exclusion criteria: * current puncture problems (f. ex. infection)

Keywords: laryngectomy larynx cancer
oral arsenic trioxide for newly diagnosed acute promyelocytic leukaemia

Conditions: Acute Promyelocytic Leukemia

Summary: acute promyelocytic leukemia (apl) is characterized by t(15;17)(q24;21) and the fusion gene pml-rara. we have formulated an oral preparation of as2o3 (oral-as2o3), and shown that it is efficacious for apl in r1, inducing cr2 in more than 90% of patients. furthermore, in an effort to prevent relapse, we have moved oral-as2o3 forward to the maintenance of cr1. this strategy results in favorable overall-survival (os) and leukemia-free-survival (lfs), implying that prolonged treatment with oral-as2o3 may prevent relapses. current protocols have incorporated i.v.-as2o3 in the treatment of newly-diagnosed apl. in regimens comprising i.v.-as2o3, atra and chemotherapy, 5-year overall survivals in excess of 90% is achieved. in this study, we evaluate the use of oral-as2o3 and atra based induction regimens in newly diagnosed patients with apl. in this study, we evaluate the efficacy and tolerability of frontline oral arsenic trioxide-based regimen in newly diagnosed patients with acute promyelocytic leukaemia


Eligibility criteria:
inclusion criteria: * newly diagnosed patients with acute promyelocytic leukaemia (apl) with t(15;17) (q24;q21)according to the world health organization (who) classification 2016 * patients aged ≥18 years * able and willing to comply with the study procedures and restrictions * having given voluntary written informed consent exclusion criteria: * ecog performance status above 2 * decompensated heart failure with left-ventricular ejection fraction of less than 40% and global hypokinesia on echocardiogram. * prolonged corrected qt interval (qtc) \> 500ms, in the absence of electrolyte disturbances and medications known to prolong qtc * significant liver function derangement (bilirubin \> 3 times upper limit normal and/or alt \> 5 times upper limit of normal) * acute myeloid leukaemia with variant rara translocation

Keywords: acute promyelocytic leukaemia oral arsenic trioxide
the effect of coconut oil on alopecia

Conditions: Breast Cancer

Summary: i̇n this study will be conducted to evaluate the effect of coconut oil on alopecia in 86 female breast cancer patients treated at dr abdurrahman yurtaslan ankara oncology training and research hospital between 01.02.2025-31.12.2025.

cancer is a disease in which the cells in our body multiply uncontrollably and develop by metastasizing, and the symptoms, course and consequences of the disease can show complex qualities in each patient. cancer treatments have benefits and harms. one of these side effects is alopecia. alopecia due to cancer treatments is a condition of hair loss, partial or complete, usually temporary but rarely permanent. in chemotherapy-induced alopecia, the hair follicle is damaged due to the pause in the anagen phase and causes the hair to break off spontaneously during activities such as washing and brushing the hair. various scales are used in the evaluation of alopecia due to cancer treatments, such as the national cancer institute common terminology criteria for side effects and the dean alopecia scale. some applications are made to prevent and treat alopecia. these include strategies and pharmacological applications to physically reduce the amount of medication given to the hair follicle. coconut oil helps regrow damaged hair. it provides essential proteins necessary for hair and softens the scalp and hair. in the literature, it has been observed that studies showing the effects of coconut oil for the prevention and treatment of alopecia are insufficient. this study will be conducted on 86 breast cancer patients to determine the effect of coconut oil on the development of alopecia.

Eligibility criteria:
inclusion criteria: * • to have been diagnosed with breast cancer. * the chemotherapy treatment plan should be planned as the doxorubicin-cyclophosphamide protocol. * volunteer to participate in the study. * be 18 years of age or older. * being a woman. exclusion criteria: * • having any health problem or disability that prevents communication (vision-hearing problems, neurological, psychiatric diseases). * planning other treatments other than the doxorubicin-cyclophosphamide protocol for the treatment of breast cancer. * not volunteering to participate in the study. * having previously experienced any disease/skin problem that causes hair loss. * having received chemotherapy before.

Keywords: alopecia breast cancer coconut oil
rirs for treatment of stones in congenital anomalous kidneys

Conditions: Renal Calculi; Renal Anomaly

Summary: the anatomic renal abnormalities like altered spatial relations with adjacent organs, abnormal calyceal orientation, and anomalous vascular patterns make the active treatment of stones in the congenitally malformed kidney a great challenge for urologists. in this prospective study, the investigators will evaluate the outcome of retrograde intrarenal surgery (rirs) with extracorporeal shockwave lithotripsy (swl) for the treatment of stones in the kidneys with rotation or position anomalies.

in current stone guidelines, the recommendations for stone therapy in the kidneys with normal anatomy are clearly stated; however, there is also no clear suggestion and treatment modality in regards to the stone treatment in anomalous kidneys. nowadays, open surgery, percutaneous nephrolithotomy (pnl), swl, and rirs are used for the treatment of these kidney stones. however, there is no clear consensus on which treatment modalities should be used; each modality has its unique advantages and drawbacks. in this study, the investigators will prospectively evaluate the safety and efficacy of rirs in treatment of stones in kidneys with rotation or position anomalies. the investigators will compare the results with a matched group of patients who were treated with swl. the results of this study may help clarify treatment options in the management of patients with stones and renal anomalies.

Eligibility criteria:
inclusion criteria: * the study will include patients with renal stones up to 20 mm in size in a kidney with rotation or position anomalies. exclusion criteria: * pregnant women. * uncorrectable coagulation disorders. * urinary tract obstruction distal to the stone. * active infection. * stone in a calyceal diverticulum
sucrose as a standard in cesarean section surgical wound healing to reduce hospital time

Conditions: Surgical Wound Infection; Cesarean Wound; Dehiscence

Summary: it is a randomized, single-blind clinical trial, whose population to be studied will be randomized patients with a diagnosis of dehiscence and infection of a cesarean surgical wound who meet the inclusion and exclusion criteria. h0: sucrose does not reduce hospital days in patients with surgical wound dehiscence. ha: sucrose reduces hospital days in patients with surgical wound dehiscence.

cesarean section is one of the most performed surgical interventions at the maternal and child hospital. infection and dehiscence of the surgical site are some of the most common complications in post-cesarean section patients. the honduran population, like those around the world, is susceptible to surgical site infections due to several risk factors and depends on each patient. regarding the patients treated at the maternal and child hospital, a surgical site risk of approximately 2-3% is estimated. therefore, the investigators consider it beneficial to look for alternatives to treating surgical infections that help to reduce hospital time. granulated sucrose has previously been used as a method for treating surgical wounds, however, no trial has been conducted to determine the benefits of its use. therefore, the investigators consider that it will be beneficial for the gynecology and obstetrics service of the maternal and child hospital, especially the septic ward, to carry out a study that helps to determine if the use of granulated sucrose reduces the hospitalization time of patients with infection and dehiscence of the surgical site due to cesarean section, as well as replacing the use of other methods that must be paid for by the patients.

Eligibility criteria:
inclusion criteria: 1. delivery of a signed and dated informed consent form. 2. declared willingness to comply with all study procedures and availability for the duration of the study. 3. women from 18 to 45 years old 4. enjoy good general health, as demonstrated by your medical history, and have been diagnosed with post-cesarean surgical wound dehiscence and fascia integra. 5. ability to take oral medication and be willing to comply with the sucrose regimen. 6. agreement to comply with lifestyle considerations exclusion criteria: 1. known allergic reactions to sucrose components. 2. treatment with another investigational drug or other intervention within the previous 7 days. 3. current smoker or tobacco consumption within the previous 3 months. 4. treatment with antibiotics at least 2 weeks before hospitalization 5. reinterventions before hospitalization -
risk factors for cytomegalovirus disease in solid organ transplantation

Conditions: Transplantation; Infection; Cytomegalovirus Infections

Summary: this study will investigate the clinical variables that may be used to predict who among the solid organ transplant recipients will develop cytomegalovirus (cmv) disease after completing antiviral prophylaxis.

this study will investigate the clinical and laboratory variables that may be used to predict who among the solid organ transplant recipients will develop cmv disease after completing antiviral prophylaxis. this is a retrospective study of patients seen at the mayo clinic during the past five years.

Eligibility criteria:
inclusion criteria: * recipients of liver, kidney, pancreas, heart or lung transplantation

Keywords: cytomegalovirus
misoprostol before and after cesarean section

Conditions: Post Partum Hemorrhage

Summary: comparison of the effect of misoprostol before and after cesarean on the blood loss

70 women who received 600 mg misoprostol rectally preoperatively versus 70 women who received 600 mg misoprostol postoperatively at operating theatre

Eligibility criteria:
inclusion criteria: * women not in active labor have reactive non-stress test. * no contraindications to prostaglandins. * have no history of coagulopathy. exclusion criteria: * placenta previa. * maternal hypertension. * diabetes mellitus. * previous cs and those with active labor. * multiple fibroid uterus. * multiple pregnancies or polyhydramnios. * previous myomectomy, previous history of pph.

Keywords: misoprostol postpartum haemorrhage
an implantable microstimulator for the chronic treatment of refractory urinary urge incontinence

Conditions: Urinary Incontinence

Summary: this clinical trial is being conducted to investigate the safety and effectiveness of a new device designed to treat urinary urge incontinence in those patients who have tried and failed two or more conservative therapies.


Eligibility criteria:
key inclusion criteria: 1. age 18 years and above. 2. diagnosed with urinary urge incontinence. 3. have no reported history of urethral obstruction/stricture, bladder calculi or bladder tumor. 4. have normal upper urinary tract function. 5. be capable of giving informed consent. 6. be capable and willing to follow all study related procedures. key exclusion criteria: 1. have any active implantable device regardless of whether stimulation status is on or off. 2. are pregnant as confirmed by a urine pregnancy test or plan to become pregnant during the following 12 months period. 3. less than one year post partum and/or are breast-feeding. 4. have any passive implant that contains metal or electrically conductive materials. 5. have conditions requiring magnetic resonance imaging (mri) evaluation. 6. have conditions requiring diathermy procedures. 7. have an inability to operate the bion remote control and bion recharging system either by self or caregiver. 8. have diabetes with peripheral nerve involvement or have severe uncontrolled diabetes. 9. have history of coagulopathy or bleeding disorder. 10. have a history of pelvic pain as primary diagnosis. 11. have anatomical restrictions such that the study device placement is not possible. 12. are currently participating or have participated within the past 30 days in any clinical investigation involving or impacting urinary or renal function. 13. have a life expectancy of less than 1 year. 14. cannot independently comprehend and complete the qol questionnaires.

Keywords: incontinence refractory urinary urge stimulation nerve microstimulator neuromodulation
"effects of neuromuscular reeducation versus post facilitation stretch technique for upper cross syndrome among it professionals

Conditions: Upper Cross Syndrome

Summary: this study is a randomised control trial and the purpose of this study is to determine the "effects of neuromuscular reeducation versus post facilitation stretch technique for upper cross syndrome among it professionals .

the purpose of this study is to determine the "effects of neuromuscular reeducation versus post facilitation stretch technique for upper cross syndrome among it professionals we make 2 groups control and treatment group . we give nmr technique to treatment group and pfs technique to control group in patients with upper cross syndrome. first we take base line readings of cervical rom , nprs and neck diasbilty index. after 2 weeks of treatment again we take same readings and compare both readings. with techniques we also perform strengthning excercise of weal muscles for both groups

Eligibility criteria:
inclusion criteria: * it profressionals * 20 - 40 years * both genders * diagnosed ucs * pain from 2 months * minimum 4 - 6 hiurs working exclusion criteria: * history of cervical spine * fracture * trauma to neck