Kornimate/medical-research-clean huggingface dataset:
study on osseospeed™ tx narrow implants in the upper jaw in a chinese population

Conditions: Partially Edentulous Jaw

Summary: the purpose of this study is to investigate the clinical efficacy of osseospeed™ tx 3mm diameter implant in a chinese population by evaluation of marginal bone level alteration, implant stability and implant survival in the posterior maxilla up to 3 years after loading. hypothesis: early loading of the 3 mm implant is a safe and predictable procedure.


Eligibility criteria:
inclusion criteria: 1. provision of informed consent 2. aged 20-75 years at enrollment 3. history of edentulism in the study area of at least two months 4. neighboring tooth/teeth to the planned crown(s) must have natural root(s) 5. presence of natural teeth, partial prosthesis and/or implants in the opposite jaw in contact with the planned crowns 6. deemed by the investigator to have a bone height and width suitable for 3.0 mm diameter study implant 7. deemed by the investigator as likely to present an initially stable implant situation exclusion criteria: 1. unlikely to be able to comply with study procedures, as judged by the investigator 2. uncontrolled pathologic processes in the oral cavity 3. known or suspected current malignancy 4. history of radiation therapy in the head and neck region 5. history of chemotherapy within 5 years prior to surgery 6. systemic or local disease or condition that could compromise post-operative healing and/or osseointegration, as deemed by the investigator 7. uncontrolled diabetes mellitus 8. corticosteroids or any other medication that could influence post-operative healing and/or osseointegration 9. smoking more than 10 cigarettes per day 10. present alcohol and/or drug abuse 11. involvement in the planning and conduct of the study (applies to both astra tech staff and staff at the study site) 12. previous enrollment in the present study 13. simultaneous participation in another clinical study, or participation in a clinical study during the last weeks prior to enrollment
post-market study of robotic-arm assisted total knee arthroplasty

Conditions: Osteoarthritis, Knee

Summary: this is an early user evaluation of the robotic-assisted total knee arthroplasty platform. the objective of this surgeon group is to capture data on the defined objectives and provide stryker with feedback.


Eligibility criteria:
inclusion criteria: * patient requires primary total knee surgery * patient is willing and able to comply with postoperative follow-up requirements and self evaluations * patient is willing to sign an irb approved informed consent * patient is at least 18 years of age exclusion criteria: * patient has a bmi \> 50 * patient is skeletally immature * patient has an active infection or suspected infection in or about the joint * bone stock that is inadequate to support fixation of the prosthesis * neuromuscular disorders, muscular atrophy or vascular deficiency in the affected limb rendering the procedure unjustified. * patients with mental or neurological conditions which may be incapable of following instructions. * blood supply limitations * collateral ligament insufficiency. * patients with prior htos or unis.
diaphragm function in low back pain people

Conditions: Low Back Pain; Low Back Pain, Mechanical

Summary: pathomechanism of nonspecific low back pain is not clear for the researchers yet. our aim is to evaluate the function of one of the stabilizer muscles of the low back area. diaphragm's postural function is evident. however, we do not understand its changes of function in low back pain. postural function of diaphragm was screened in supine position and in sitting too in a relaxed and in a contracted state. the thickness of diaphragm was measured and contraction ratio was calculated. additionally, the stability limits of the trunk were measured. we were curios about the differencies in contraction ratio between asymptomatic and low back pain individuals.

pathomechanism of nonspecific low back pain is not clear for the researchers yet. our aim is to evaluate the function of one of the stabilizer muscles of the low back area. diaphragm's postural function is evident. however, we do not understand its changes of function in low back pain. the postural function of diaphragm was screened with zonare zone ultrasound system in supine position and in sitting too in a relaxed and in a contracted state. the thickness of diaphragm was measured by using an elecric caliper of the ultrasound device and the contraction ratio was calculated. additionally, the stability limits of the trunk were measured with sitting functional reach and sitting lateral reach tests. we were curios about the differencies in contraction ratio between asymptomatic and low back pain individuals.

Eligibility criteria:
inclusion criteria: * capable to get the scene of the measurements * age is over 18 exclusion criteria: * serious neurologycal disorder, which affects the performance on the functional tests * previous surgical intervention which has been affected the trunk * intensive pain, which prevent the individual to perform the needed positions (supine and sitting) * serious lung disease or breathing disorder

Keywords: lbp diaphragm msk ultrasound
comparing intubating conditions using succinylcholine or rocuronium for rigid bronchoscopy

Conditions: Intubating Conditions; Postoperative Myalgia; Patient Satisfaction

Summary: succinylcholine is commonly used for neuromuscular relaxation for short procedures such as rigid bronchoscopy. a more modern alternative is the application aof rocuronium, reversed by sugammadex. the investigators compare the intubating conditions, incidence of postoperative myalgia (pom) as well as patient satisfaction for these two muscle relaxants.


Eligibility criteria:
inclusion criteria: * age \> 18 yr * scheduled for elective rigid bronchoscopy exclusion criteria: * known neuromuscular disease * significant hepatic or renal dysfunction * family history of malignant hyperthermia * known allergy to one of the drugs used in this protocol * pregnancy or breastfeeding

Keywords: succinylcholine rocuronium rigid bronchoscopy
phase ii study of reuse of oxaliplatin hypersensitivity in gastrointestinal tumors

Conditions: Gastrointestinal Tumors

Summary: the incidence of oxaliplatin allergy reactions is between 12-15%, while the incidence of severe (grade 3-4) allergic reactions is between 0.5-2%. the purpose of this study is to prospectively investigate the incidence of oxaliplatin allergy and neurotoxicity, and to evaluate the use of effective anti-allergic and desensitization therapies to enable patients who are already allergic to oxaliplatin to complete their prescribed doses smoothly.

the incidence of oxaliplatin allergy reactions is between 12-15%, while the incidence of severe (grade 3-4) allergic reactions is between 0.5-2%. the purpose of this study is to prospectively investigate the incidence of oxaliplatin allergy and neurotoxicity, and to evaluate the use of effective anti-allergic and desensitization therapies to enable patients who are already allergic to oxaliplatin to complete their prescribed doses smoothly. patients with gi receiving oxaliplatin-containing regimens were prospectively observed, and patients with oxaliplatin grade i-iii hypersensitivity reactions judged by clinicians based on clinical symptoms and signs entered the oxaliplatin reuse study . for patients with grade i-iii oxaliplatin allergy, oxaliplatin skin test with 3 concentration gradients (0.01 mg/ml, 0.1 mg/ml and 5 mg/ml) was performed, and 5% glucose water served as a negative control. 15-20 minutes to read test results. if the largest diameter of the rash was greater than 3 mm of the negative control, it was judged as a positive result. afterwards, interventions were performed in different ways according to the grade of oxaliplatin allergic reaction.

Eligibility criteria:
inclusion criteria: 1. patients who plan to receive oxaliplatin treatment; 2. male or female aged 18-75 year; 3. ecog ps 0-2; 4. the expected survival time is more than 3 months; 5. capable and willing to accept survey patients exclusion criteria: 1.patients who were not suitable for the enrollment of this study judged by the investigator
evaluation in the treatment of nosocomial sepsis comparing polymerase chain reaction with conventional blood culture.

Conditions: Sepsis; Bacteremia; Fungemia

Summary: the objective of this study is to evaluate the consumption of antimicrobial therapy in patients comparing a rapid molecular test (pcr in real-time multiplex) with blood cultures to identify the etiological agents of sepsis.

patients staying more than 48 hours in hospital with clinical suspicion of sepsis could be included in the study. blood samples for cultures and multiplex pcr will be collected immediately prior to initiation of antibiotic therapy. patients will be randomly selected into two groups. in group i, the pcr results will be immediately reported to the medical researcher (6-12 hours), which will change the antimicrobial regimen (de-escalation). in group ii, the multiplex pcr results will not be informed, being focused care as a result of blood culture (at least after 72 hours). the initial empirical antimicrobial therapy will be the same in both groups, according to the standardization of the institution.

Eligibility criteria:
inclusion criteria: * patient 18 or more years old * patient staying more than 48 hours in hospital * patient with clinical suspicion of infection and presenting at leat two of the following criteria:temperature \> 38oc or \ 90 beats/minute, respiratory rate \> 20 breaths/minute or paco2 \ 12 000/μl or leukopenia \ 10% immature forms * patient or responsible able to provide informed consent exclusion criteria: * patient submitted to cardiovascular surgery in the last fifteen days * patient or responsible are not able to provide informed consent

Keywords: sepsis real time pcr blood culture bacteremia diagnosis fungemia diagnosis
survival of implant-supported all-ceramic prostheses

Conditions: Partial Edentulism; Disorder of Prostheses and Implants; Dental Prosthesis Failure

Summary: the purpose of this research study is to identify reasons that cause an all-ceramic bridge to fracture which include the thickness of the bridge material, the type of bridge material and the bite force of the person. this all-ceramic bridge will be compared to a metal-ceramic bridge. the investigators are conducting this study so we can make bridges which can withstand forces in the mouth which tend to break them. the overall objective of this research is to analyze how properties of ceramic materials and different forces in the mouth interact with each other to affect the longevity of these bridges. these include fracture toughness, elastic modulus of ceramic layers and supporting substrate, core thickness, connector height, wear, loading orientation, and maximum clenching force.

the long-range goal of the proposed research is to formulate design survival statistics that will aid the dental community in fabricating properly designed prostheses that can predictably survive the oral environment. patients who qualify for this study will be randomized (as in chanced with the flip of a coin) into two groups. the first group is a metal-ceramic group where patients will receive a bridge with a metal substructure underneath. the second group is an all-ceramic group where patients will receive a bridge which is made of hard ceramic material. all patients will receive two dental implants which will bond to bone for a period of 4-6 months. an impression or mold of the implants will then be made and a bridge will be fabricated based on the randomization of the patient. patients will be asked to return at 6 months and yearly thereafter up to 5 years. during these recall appointments, photographs will be taken and impressions of the bridge and other teeth will be made. this will allow us to measure the amount of wear happening with the bridge and the other teeth. the investigators can also examine the amount of bone around the implants as well as the integrity of the bridge.

Eligibility criteria:
inclusion criteria: * aged between 21-75 years, and no contraindications to dental treatment. * good overall dental health, no active caries, no periodontal disease, and periodontal pocket depths not greater than 4 mm. * missing at least three teeth in the posterior area of the mouth. * natural teeth opposing the edentulous area and a full complement of teeth or restored teeth in all other areas of the mouth * adequate bone height and width at areas of proposed implant sites * adequate interocclusal distance to accommodate prosthesis * good oral hygiene and compliance with oral hygiene instructions as determined by the amount of plaque present on tooth surfaces. * compliance with appointments and willing to pay $2625 for a 3-unit implant supported fdp exclusion criteria: non compliance not enough teeth remaining uncontrolled medical condition
inspiratory muscle training in ventilator dependent patients

Conditions: Failure to Wean; Respiratory Failure; Ventilator Dependent

Summary: the purpose of this study is to determine if inspiratory muscle strength training will increase the proportion of ventilator dependent patients weaned versus sham treated patients.

the inspiratory muscle strength training consists of 4 sets of 6-10 breaths through a threshold inspiratory muscle strength training device, 5 days per week. the inspiratory muscle training is conducted at the highest pressure setting tolerated by the patients. the sham groups uses an inspiratory muscle trainer that does not increase inspiratory muscle strength. both the treated and sham groups participate in progressively lengthening periods of breathing without ventilator as tolerated. patients are considered weaned when they can breathe for 72 consecutive hours without any ventilator support.

Eligibility criteria:
inclusion criteria: * failure to wean patients in the medial, surgical and intermediate respiratory care units at shands hospital * medically stable * able to initiate spontaneous breaths * able to provide informed consent * able to follow simple instructions exclusion criteria: * life expectancy \< 12 months due to malignancy * damaged phrenic nerves * neuromuscular diseases * heart or lung transplant

Keywords: ventilator weaning weaning respiratory failure inspiratory muscle strength training
clinical and financial impact of an evidenced-based adhesive small bowel obstruction management protocol

Conditions: Intestinal Obstruction

Summary: this research study is for patients with adhesive small bowel obstruction (asbo). asbo is a condition in which the small intestine gets blocked due to scars called adhesions. to see the blockage, a contrast agent is given and an x-ray is taken of the belly (abdomen). md gastroview and omnipaque are two contrast agents that may be given as part of your normal care for asbo. this study hopes to see if one is better than the other.

small bowel obstruction is a common general surgical diagnosis providing a significant proportion (16%) of the emergency general surgery admissions. unfortunately, there is a paucity of clear, well defined management protocols for this very common problem which results in a wide array of management techniques used by the general surgeon. it has already been shown that ct scan with iv contrast is the most accurate method of identifying strangulated bowel, a diagnosis that requires urgent surgical intervention(4). there is no variability in this aspect of the treatment arm for asbo, rather the variability is found in the medical management of asbo. nasogastric tube (ngt) decompression is a universal component of non-operative management but the duration of ngt therapy and the definition of failed medical management requiring surgery lack a clear consensus. it is this aspect of the management of asbo that i am hoping to better define. water soluble contrast (md-gastroview) has been shown to be both diagnostic and therapeutic in the management of asbo decreasing length of stay in this patient population. not only does it expedite the resolution of asbo, but is also yields objective evidence whether or not asbo will resolve with medical management alone, therefore decreasing delay in the inevitable surgical intervention. the hypothesis of this study is that the implementation of an evidence based adhesive small bowel obstruction protocol can reduce length of stay and reduce the financial burden on the health care system regarding this common general surgical problem. a second hypothesis is that md-gastroview and omnipaque will have similar properties regarding their diagnostic and therapeutic impact on asbo.

Eligibility criteria:
inclusion criteria: * principle diagnosis of adhesive small bowel obstruction exclusion criteria: * evidence of strangulation on initial ct scan leading to emergent operation * any known allergy to either contrast agent
a study to analyse the immediate effect of dry needling and extra corporeal shock wave therapy on hand grip strength

Conditions: Muscle Weakness Condition

Summary: an argument to analyse the immediate effect of dry needling or extra corporeal shock wave therapy on hand grip strength in normal healthy individuals with a hypothesis of dry needling or shock wave on forearm muscles have influence on the hand grip strength.

after written consent obtained from all the participants randomization and allocation will be done with sealed non transparent envelopes and participants will be assign to two groups dry needling(dn) and extra corporeal shock wave therapy (eswt).pre and post data of hand grip strength measured with jamar hand dynamometer.post data shall be collected precisely after 1 hr of intervention from both groups.

Eligibility criteria:
inclusion criteria: * no pain on the visual analog scoring scale of 100 mm scale, * muscle power of 4+ on oxford manual muscle testing of forearm and wrist extrinsic and intrinsic muscles * full range of motion in all dominant upper extremity joints. exclusion criteria: * history of previous fractures of the dominant upper extremity, * teno-synovitis of flexor tendons , * dequervains synovitis, * left hand dominance.

Keywords: dry needling extra corporeal shockwave therapy hand grip strength post 1 hour
the acute effect of interval-walking

Conditions: Type 2 Diabetes Mellitus

Summary: four months of interval walking training (iwt) is superior to energy-expenditure matched continuous walking training (cwt) with regards to weight loss and improvements in glycemic control. the reason for this is unclear. one potential explanation for the differential outcome in weight loss is excess post-exercise oxygen consumption (epoc), which is defined as the elevated oxygen consumption measured during the hours following an exercise bout. a large epoc means greater energy expenditure which, if energy intake does not change, leads to a greater weight loss. this weight loss may subsequently improve glycemic control * aim 1: to assess the effect of an acute bout of iwt vs. an acute bout of cwt on glycemic control in type 2 diabetics and to assess mechanisms responsible for differences (if any). it is hypothesised that iwt will be more advantageous for improving glycemic control. * aim 2: to examine the effect of an acute bout of iwt vs. an acute bout of cwt on epoc. it is hypothesised that iwt will produce an epoc of larger magnitude than cwt.


Eligibility criteria:
inclusion criteria: * diabetes mellitus, type 2 exclusion criteria: * smoking * pregnancy * insulin dependence * contraindication to physical activity (as judged by medical history and screening) * evidence of thyroid, liver, lung, kidney or heart disease

Keywords: glycemic control excess post-exercise oxygen consumption
mepitel film treatment for the prevention and cutaneous toxicity due to radiotherapy

Conditions: Post-surgery Radiotherapy

Summary: this is a randomized study, mepitel vs standard of care for the prevention and skin toxicity due to radiotherapy in patients with post-surgery breast cancer. mepitel film will be placed on the skin of the patients just before the start of the radiotherapy and will be replaced once a week until the end of the radiotherapy. in case of skin toxicities mepitel film will be placed until resolution of toxicities.

for patients randomized in the mepitel arm: mepitel film will be placed on the patients' skin just before the start of the radiotherapy and will be replaced once a week until the end of the radiotherapy. in case of skin toxicities mepitel film will be placed until resolution of the toxicities. in case of new skin toxicities appearance the patient will be retreated with mepitel. for patients randomized in the standard of treatment arm: patients will be treated with aqueous (excipial u hydrolotion) or antiseptic (flammazine o ialugen plus) cream in case of skin erythema. in case of new skin toxicities appearance the patient will be retreated with standard of care treatment.

Eligibility criteria:
inclusion criteria: * patients with breast cancer treated with conservative surgery who need radiotherapy treatment * capability and willness to participate to the study * informed consent form signature exclusion criteria: * contraindication to the correct placement of the mepitel film * previous breast radiation treatment * participating in other clinical trials * previous breast reconstruction * concomitant treatment with antiblastic chemotherapy
study to evaluate viagra's ability to provide a better sexual experience through quality erections and satisfaction

Conditions: Impotence

Summary: the study objective is to: 1. to evaluate the effect of sildenafil citrate versus placebo on the iief_ef domain at the end of the double-blind phase 2. to assess the relationship between treatment with sildenafil citrate or placebo and responses to the quality of erection questionnaire (qeq) and sexual experience questionnaire (sex_q).


Eligibility criteria:
inclusion criteria: * male subjects aged 18-65. * documented clinical diagnosis of erectile dysfunction confirmed by an iief-ef domain score of less than or equal to 25. (if the subject scores greater than 25 on the iief-ef domain, screening procedures should be terminated.) exclusion criteria: * subjects who have been treated with more than 6 doses of sildenafil citrate or any other phosphodiesterase type 5 (pde-5) inhibitor such as vardenafil or tadalafil for erectile dysfunction \[note: subjects should not have taken any pde-5 inhibitors within 4 weeks prior to the date of screening\].
evaluating a new iloperidone titration scheme in bipolar i disorder or schizophrenia

Conditions: Bipolar I Disorder; Schizophrenia

Summary: this is a single-center open-label study to be conducted in the united states in subjects with bipolar i disorder or schizophrenia.


Eligibility criteria:
inclusion criteria: * male or female patients 18 to 65 years of age (inclusive) * diagnosed with either schizophrenia or bipolar i disorder, manic or mixed type as per dsm-v criteria * symptomatically stable within the past two months exclusion criteria: * exposure to any investigational medication, including placebo, in the past 60 days * non-response to clozapine