Kornimate/medical-research-clean huggingface dataset:
study evaluating pantoprazole in children with gerd

Conditions: Gastroesophageal Reflux

Summary: the purpose of this study is to characterize the pk profile, safety and tolerability of single and multiple doses of pantoprazole in children aged 1 through 11 years with endoscopically proven gerd.


Eligibility criteria:
inclusion criteria: * endoscopically proven gerd diagnosed within 6 months before study entry. * weight must be equal to or over 8.3 kg; for subjects 6 years or greater, weight must be equal to or under 25 kg exclusion criteria: * history of gi disorders, ie, unrepaired tracheal esophageal fistula, gi malabsorption, eosinophilic esophagitis * subjects 6-11 years old unable to swallow tablets

Keywords: gastrointestinal reflux disease
safety, tolerability and efficacy of zd6126 in combination with oxaliplatin, 5-fluorouracil and leucovorin in subjects with metastatic colorectal cancer.

Conditions: Colorectal Neoplasms; Metastases, Neoplasm

Summary: the purpose of this study is to assess the safety, tolerability and efficacy of zd6126 in combination with oxaliplatin, 5-fluorouracil and leucovorin in subjects with metastatic colorectal cancer.


Eligibility criteria:
inclusion criteria: * metastatic colorectal carcinoma * suitable for first-line treatment of metastatic disease exclusion criteria: * peripheral neuropathy greater than grade 1 * adjuvant therapy within 6 months prior to study treatment * prior oxaliplatin * prior pelvic or whole abdomen radiation * any history of coronary angioplasty or history of myocardial infarction

Keywords: metastatic colorectal first-line adjuvant cancer colorectal cancer colorectal carcinoma colorectal tumors neoplasms, colorectal
effect of thoracic epidural analgesia for thoracotomy on the occurrence of af

Conditions: Posterolateral Thoracotomy; Lung Resection; Thoracic Epidural Analgesia; Sympathetic Outflow; Atrial Fibrillation

Summary: thoracic epidural anesthesia and analgesia for patients undergoing lung resection can reduce the occurrence of af if it is continued for six postoperative days instead of just three.

thea is considered a very effective technique of providing intra and post-operative analgesia for thoracic surgical procedure and it seems that can also be effective in reducing the incidence of postoperative af in patients undergoing lung resection. nevertheless the timing of stopping the epidural analgesia and its further substitution with other therapies, remains unclear. in this study patients who are scheduled for lung resection surgery will undergo the surgery under combined general anesthesia with volatile anesthetics and thoracic epidural anesthesia. immediately after surgery the patients will be divided into two groups: * those who will receive thoracic epidural analgesia for 6 days * those who will receive thoracic epidural analgesia for 3 days and will then switch to intravenous morphine for another 3 days all the patients will be monitored daily for arrythmias

Eligibility criteria:
inclusion criteria: * lung resection * pneumonectomy exclusion criteria: * patient refusal * af (present or in the past * contraindications for epidural catheter placement

Keywords: thoracotomy thoracic epidural analgesia arrythmiogenesis atrial fibrillation sympathetic outflow
therapeutic instrumental music performance with sensory-enhanced motor imagery in chronic post-stroke rehabilitation

Conditions: Stroke

Summary: research has shown that music engages the brain bilaterally throughout cortical and subcortical regions, accessing extended sensorimotor, cognitive and affective networks. this research explores the hypothesis that use of these shared neural networks allows neurologic music therapy interventions targeting upper extremity motor control to promote plasticity and functional improvements in persons recovering from a cerebrovascular accident. the potential therapeutic benefits of these interventions on attentional processes and affective responding will also be examined.

more individuals are surviving and living with the effects of stroke, a trend that is expected to continue. upper extremity limitations present a common, persistent challenge for stroke survivors, impacting quality of life. in addition, links have been found between physical impairment and depression, and depression and stroke-induced cognitive impairment. music has been shown to exert multimodal effects on individuals and may be used as a mediating stimulus to promote therapeutic change. furthermore, motor imagery may enhance the effectiveness of upper extremity interventions by engaging the same brain areas that are active in physical movement. the purpose of this study is to investigate the effects of therapeutic instrumental music performance and sensory-enhanced motor imagery on upper limb movement, affect and cognition following a stroke. participants will be assessed at two baselines, and randomly assigned to one of three intervention groups: therapeutic instrumental music performance, therapeutic instrumental music performance and sensory-enhanced motor imagery, or therapeutic instrumental music performance and motor imagery without sensory enhancement.

Eligibility criteria:
inclusion criteria: * hemiparesis following a unilateral stroke (hemorrhagic or ischemic), sustained more than 6 months prior, with at least minimal volitional movement of the affected limb * permission from a physician to participate in an upper extremity rehabilitation program, including confirmation that the following disorders are not present: rheumatoid arthritis, upper extremity fracture, apraxia, neuropathy, somatosensory impairment * adequate language comprehension and neurocognitive function to understand and follow simple instructions exclusion criteria: * currently enrolled in an upper extremity rehabilitation program or another upper extremity study * comorbid neurological disorder (e.g. multiple sclerosis, parkinson's disease) * evidence of perceptual or cognitive impairment; e.g., unilateral spatial neglect, significant hearing impairment, montreal cognitive assessment score of 25 or less * presence of aphasia * injections for spasticity within three months of participation
fluticasone versus esomeprazole to treat eosinophilic esophagitis

Conditions: Eosinophilic Esophagitis

Summary: the purpose of this study is to assess the clinical efficacy of proton pump inhibitors in comparison to aerosolized swallowed steroids for the treatment of eosinophilic esophagitis (ee). ee is an increasingly recognized disorder that has been associated with dysphagia and food impaction. the presence of anatomical abnormalities in the esophagus such as longitudinal furrows, corrugated rings and a narrow caliber esophagus with friable mucosa are classic endoscopic findings. diagnosis is established with the histologic finding of large numbers (\> 15) of eosinophils per high power field. the underlying pathologic mechanism remains poorly understood but food allergies and aeroallergens have been implicated. it is well known that gastroesophageal reflux disease (gerd) may cause esophageal eosinophilia, but it is unclear whether a complex relationship exists between gerd and ee, as recent data suggests. furthermore, a large number of patients with clinical presentations and endoscopic findings highly suggestive of ee which is confirmed on histology are responding favorably to proton pump inhibitors. the aims of the study are to (1) compare the clinical efficacy of aerosolized swallowed fluticasone to esomeprazole for the treatment of eosinophilic esophagitis, (2) determine whether proton pump inhibitors are effective in the treatment of eosinophilic esophagitis, (3) determine the number of patients with eosinophilic esophagitis that have coexisting gastroesophageal reflux disease, and (4) correlate change in eosinophil count to improvement in symptoms before and after therapy.


Eligibility criteria:
inclusion criteria: * patients with an established diagnosis of ee defined as \> 20 eosinophils/hpf in the setting of dysphagia or food impaction. * males and females age \> 18 years of age. * ability to undergo ambulatory ph monitoring. * deers (defense enrollment eligibility reporting system) eligible. * willingness to take a one month holiday from a ppi or steroids if they have been prescribed this prior to enrollment. * willingness to participate and have additional biopsies taken during endoscopy and answer a questionnaire. exclusion criteria: * patients \< 18 years of age. * inability to give consent. * inability to undergo endoscopy or contraindications to endoscopy. any medical condition or disorder (including drug allergies), which would preclude the use of conscious sedation or the ability to tolerate upper endoscopy. * contraindications to proton pump inhibitors or steroids. * inability to accurately fill out a short questionnaire. * pregnant females. a urine beta human chorionic gonadotropin (bhcg) prior to endoscopy will be offered to all female patients of child bearing potential (exceptions include post-menopausal, hysterectomy or bilateral tubal ligation). positive bhcg results will prevent enrollment. * known coagulation abnormalities, thrombocytopenia and patients on coumadin.

Keywords: eosinophilic esophagitis acid reflux
study of quinvaxem for vaccination against diphtheria, pertussis, tetanus, hepatitis b and diseases caused by haemophilus influenzae type b

Conditions: Diphtheria; Pertussis; Tetanus; Hepatitis B; Haemophilus Influenzae Infections

Summary: the aim of this study was to evaluate the immunogenicity and safety of the quinvaxem vaccine (a liquid combination vaccine against diphtheria, tetanus, b. pertussis, hepatitis b and h. influenzae type b). healthy vietnamese infants received three doses of vaccine at 2, 3 and 4 months of age according to the local expanded programme on immunisation (epi) schedule


Eligibility criteria:
inclusion criteria: * infants are at age of dtp vaccination of the local epi program (60-120 days old) and free from any obvious health problems * have a normal gestational age (≥ 37 weeks); birth weight \> 2.5 kg * there is no congenital disease detected through interview and clinical examination * already had or not yet received hepatitis b vaccination at birth * do not have dermatological diseases such as eczema, allergies * parent or legal guardian voluntarily provides consent for their child for participation in the study by signing the informed consent and agrees to comply with all study procedures exclusion criteria: * already vaccinated with dtp vaccine * have an acute infection at the time of study vaccination * contraindications to quinvaxem * receiving treatment with systemic corticosteroids * currently participating in another clinical trial * in receipt of a parenteral immunoglobulin preparation and/or blood/blood products since birth * parents intend to move to another location during the study (the next 12 months)

Keywords: vaccination immunisation virus diphtheria pertussis tetanus hepatitis b haemophilus influenzae immunity
dose finding study in copd

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: the primary objective of this study is to determine the optimum dose of bea 2180 br inhalation solut ion delivered by the respimat ? inhaler once daily for four weeks in patients with copd.


Eligibility criteria:
1. patients must have relatively stable, moderate to severe airway obstruction with an fev1 \>=30% and \<= 60% of predicted normal and fev1 \<=70% of fvc at the baseline pfts at visit 1 (at both timepoints). 2. all patients must have an increase in fev1 of at least 12% from baseline (th e -10 minute measurement) 45 min after inhalation of 80 ?g atrovent mdi. 3. male or female patients 40 years of age or older. 4. smoker or ex-smoker with a history of more than 10 pack years. 1. patients with any other significant disease will be excluded. 2. patients with a history of asthma or allergic rhinitis will be excluded.
assessment of the uterus using ultrasonographic elastography in women with dysmenorrhea

Conditions: Primary Dysmenorrhea

Summary: the aim of this study is to perform sonoelastographic assessment of the uterus in patients diagnosed with primary dysmenorrhea and to compare these measurements with sonoelastographic evaluations of the uteri in asymptomatic individuals. this will enable, for the first time, the demonstration of whether the elasticity of the myometrial tissue contributes to the etiology of primary dysmenorrhea. secondary objectives: to determine whether there is a correlation between the severity of primary dysmenorrhea and ultrasonographic markers.


Eligibility criteria:
inclusion criteria: 1. women aged 18-40 years. 2. women with primary dysmenorrhea who are willing to participate in the study. 3. women without primary or secondary dysmenorrhea who agree to participate as a control group. exclusion criteria: 1. women with secondary dysmenorrhea. 2. patients with underlying uterine or adnexal pathologies (e.g., endometrial polyps, adenomyosis, uterine fibroids, adnexal masses, ovarian pathologies and cysts) identified via ultrasonography. 3. individuals with a history of uterine surgery. 4. individuals with a history of pelvic surgery. 5. individuals who have delivered via normal spontaneous vaginal delivery or cesarean section.

Keywords: dysmenorrhea sonoelastography
autologous bone marrow stem cells in cirrhosis patients

Conditions: Stem Cell Transplantation; Cirrhosis

Summary: liver cirrhosis (lc) is the end stage of chronic liver disease. the liver transplantation is one of the only effective therapies available to such patients. however, lack of donors, surgical complications, rejection, and high cost are it's serious problems. the potential for stem cells in bone marrow (bm) to differentiate into hepatocytes cells was recently confirmed. moreover, bmc transplantation has been performed to treat hematological diseases, and several clinical studies have applied bmc injection to induce regeneration of myocardium and blood vessels. in this study we will evaluate safety and feasibility of autologous bone marrow mono nuclear (bm-mnc) and enriched cd133+ hematopoietic stem cell transplantation through the portal vein in patients with decompensate cirrhosis.

bm (200 ml) will be harvested from the iliac crest according to standard procedures under general anesthesia and is collected in plastic bags containing anti coagulant. after precipitation of red blood cells, low density mononuclear cells will be collected by centrifugation in ficoll-paque density gradient. for cd133+ cells separation the clinimacs instrument will be used. cells are injected via portal vein under sonography monitoring. after cell therapy, patients are followed up every week for 4 weeks, and laboratory data are analyzed for 24 weeks.

Eligibility criteria:
inclusion criteria: * liver biopsy showing histological cirrhosis, grade b or c (child-pugh score) * alkaline phosphatase between 2 x to 3x normal value * liver cirrhosis in sonography study * incomplete response to udca after 6 months of treatment. * negative pregnancy test (female patients in fertile age) * written consent exclusion criteria: * presence of active hepatic encephalopathy * refractory ascites * evidences of active autoimmune liver disease (e.g. gamma globulin of more than 2 times of upper limit of normal, and alt \> 3 times normal in patients with autoimmune hepatitis) * hepatocellular carcinoma or other malignancies * sepsis * presence of significant extrahepatic biliary disease (e.g. cbd stone, psc, etc.) * hiv, hbv or hcv infection * cardiac, renal or respiratory failure * active thrombosis of the portal or hepatic veins * inr\>2

Keywords: autologous bone marrow stem cells cirrhosis
oxygen insuflation and arterialdesaturation during tracheal intubation in children

Conditions: Infants; Difficult Airway

Summary: infants (0-1 yr.) with anticipated difficult airways will be enrolled in the study. specifically, we will include infants with cleft palate, pierre robin, treacher collins, trisomy 21, or similar congenital malformations. patients with american society of anesthesiologists physical status scores ≥3 will be excluded, as will those with congenital heart disease and left-to-right shunting. patients will be randomly assigned to laryngoscopy with or without simultaneous insufflation of oxygen at 4 l/minute. oxygen will be provided by a flowmeter connected via rigid tubing to the track-mounted endotracheal tube on the airtraq. randomization (1:1) will be based on computer-generated codes with random block sizes and stratified by hospital; allocation will be concealed and provided to clinicians via a secure web site that will be accessed shortly before induction of anesthesia.


Eligibility criteria:
inclusion criteria: * infants (0-2) difficult airways exclusion criteria: * . patients with american society of anesthesiologists physical status scores ≥3 congenital heart disease left-to-right shunting

Keywords: infants with cleft palate pierre robin treacher collins trisomy 21
impact of equestrian sports, crossfit, and gym training on pelvic floor health (pelfisport )

Conditions: Pelvic Floor Dysfunction; Urinary Incontinence; Pelvic Organ Prolapse (POP); Chronic Pelvic Pain

Summary: this observational cross-sectional study investigates the impact of equestrian sports, crossfit, and gym training on pelvic floor health in both athletes and non-athletes. the study aims to determine whether specific sports are associated with a higher risk of pelvic floor dysfunction, including urinary incontinence, pelvic organ prolapse, and chronic pelvic pain. participants will complete an online survey that collects demographic information, sports participation details, and pelvic floor health symptoms. the survey includes standardized questionnaires to assess pelvic floor function. data will be analyzed to compare the prevalence of pelvic floor issues among different sports and between athletes and non-athletes. the study seeks to provide insights into how sports participation influences pelvic health and to raise awareness of pelvic floor dysfunction in both male and female athletes.


Eligibility criteria:
inclusion criteria: * adults 18 years or older. * voluntary participation with signed informed consent. * completion of the online survey. * for the sports groups (equestrian, crossfit, gym, other sports): * minimum 2 years of experience in the sport. * minimum 2 training sessions per week. exclusion criteria: * individuals under 18 years old. * participants who do not complete the survey. * individuals with neurological conditions affecting mobility. * individuals with mobility impairments unrelated to sports. * sports participants with less than 2 years of experience or training less than twice per week.

Keywords: urinary incontinence pelvic organ prolapse chronic pelvic pain equestrian sports crossfit gym training women&#39;s health physical activity
the relationship between covid-19 anxiety level and emotional eating in individuals with metabolic syndrome

Conditions: Metabolic Syndrome; Emotional Eating; COVID-19

Summary: the aim was to determine the coronavirus anxiety levels and emotional eating status of cases with diagnosis of mets according to diagnostic criteria published by the international diabetic federation (idf) in 2005 and healthy individuals with similar bmi to mets subjects.

the aim was to determine the coronavirus anxiety levels and emotional eating status of cases with diagnosis of mets according to diagnostic criteria published by the international diabetic federation (idf) in 2005 and healthy individuals with similar bmi to mets subjects. this study was completed with the descriptive, cross-sectional and relational screening model. the full sampling method was used in the study. the study was completed with 105 individuals with metabolic syndrome attending the diet clinic and 109 healthy individuals without mets diagnosis also attending the diet clinic. collection of data used anthropometric measurements and biochemical findings, blood pressure and a survey form, the coronavirus anxiety scale (cas) and emotional eating scale (ees).

Eligibility criteria:
inclusion criteria: * the research included individuals aged 18 years and older, who were not pregnant or breastfeeding, without any psychological disorder diagnosed by psychiatry, without diagnosis of covid-19 and not using any psychiatric medications. the mets group for the research included individuals with metabolic syndrome diagnosis according to idf-2005 diagnostic criteria. the non mets group in the research included healthy individuals not using any psychiatric medications, without any chronic disorder, and with similar bmi to the individuals in the subject group. exclusion criteria: * the research included individuals aged 18 years and older, who were pregnant or breastfeeding, with psychological disorder diagnosed by psychiatry, with diagnosis of covid-19 and using psychiatric medications.

Keywords: metabolic syndrome covid-19 eating
correlation tests for patients with benign paroxysmal positional vertigo

Conditions: Positional Vertigo; Reflexes, Vestibo-Ocular; Nystagmus Vestibular

Summary: this study aimed to investigate whether there is a relationship between nystagmus intensity and vestibular-ocular reflex gains by comparing videonystagmography and video head impulse test in patients with posterior semicircular canal-benign paroxysmal positional vertigo.

the aim of this study is to investigate the relationship between the vestibulo-ocular reflex (vor) gains obtained by video head impulse test (vhit) and the slow phase velocity (spv) of nystagmus in patients with benign paroxysmal positional vertigo (bppv) originating from the posterior semicircular canal (pscc). the patients were included in two groups. the study group consisted of patients with isolated pscc bppv (pscc-bppv), and the control group consisted of age and gender-matched healthy individuals. vor gains were measured by vhit in both the study group and the control group. the spv values of the nystagmus observed during the dix-hallpike maneuver in the study group were recorded by videonystagmography (vng) and compared with the vor gains.

Eligibility criteria:
inclusion criteria: * patients with isolated benign paroxysmal positional vertigo were included in the study group. * the patients included in the control group were composed of those who did not complain of vertigo. exclusion criteria: -participants with a history of neuro-otologic disease, an orthopedic disease that prevents neck movements, and any disease or surgery that causes impairment in ocular movements were excluded from the study.

Keywords: vestibular function tests head impulse test semicircular canals
stress levels and mental well-being among slovak students during e-learning

Conditions: Anxiety State; Depression

Summary: introducing restrictions on human contact has been effective in preventing the uncontrolled spread of covid-19, however, it appears to have negatively impacted mental health. psychological problems in different age groups occur with different intensity and duration of the pandemic. this study was aimed to assess the impact of introducing distance learning (e-learning) on the stress levels and mental well-being among slovak students.

socially isolated young people, condemned to constant contact with the internet, find themselves in sorrowful situations where their basic need were impossible. previous studies report that university students report high levels of stress, anxiety, and depression, which affects student motivation and attitudes toward learning; however, to date, no such studies have been conducted on a population of slovakian students. this study considered 4 slovak universities. using standardized questionnaires, students' mental status during e-learning was assessed at the beginning of the summer semester (february, march 2021).

Eligibility criteria:
inclusion criteria: * students attending the course cycle exclusion criteria: * inability to self-complete the research questionnaires; * psychiatric or psychological treatment, likewise taking medications that affect the psyche during the research project;

Keywords: depression e-learning covid-19 anxiety