Kornimate/medical-research-clean huggingface dataset:
virtual peer-to-peer (vp2p) support mentoring for juvenile idiopathic arthritis (jia): a pilot rct

Conditions: Juvenile Idiopathic Arthritis

Summary: study hypothesis: a virtual peer-to-peer support intervention will improve health outcomes and quality of life in adolescents with juvenile idiopathic arthritis

the aim of this project is to develop and examine the impact of a virtual peer support program on health outcomes and quality of life of adolescents with juvenile idiopathic arthritis using a waitlist randomized controlled trial. in addition to standard medical care, adolescents in the experimental group will receive a manualized peer mentorship program that will provide modeling and reinforcement by trained young adults aged 16-25 years who have learned to function successfully with their pain. mentoring sessions consist of 10 sessions of 30-45 minute skype calls over 8 weeks. feasibility of the program will be measured in addition to quality of life, physical and emotional symptoms, pain coping, self-efficacy, social support, and self-management skills.

Eligibility criteria:
inclusion criteria: * males and females 12-18 years old * diagnosed with juvenile idiopathic arthritis (jia) by a rheumatologist (any sub-type) * able to speak and read english * access to internet connection, computer capable of using free skype software * willing and able to complete online measures exclusion criteria: * significant cognitive impairments * major co-morbid illnesses (i.e., psychiatric conditions) likely to influence hrql assessment * participating in peer support or self-management interventions (e.g., teens taking charge).

Keywords: adolescent skype peer mentorship internet self-management
balance in children with cochlear implants

Conditions: Cochlear Implants; Sensory-Neural Hearing Loss; Balance Disorder

Summary: cochlear implantation is performed in children with sensorineural hearing loss to restore hearing. fifty percent of children with sensory neural hearing loss, who are candidates for cochlear implant, have vestibular (inner ear) dysfunction prior to surgery. anatomically, the cochlea, semicircular canals, and otolith organs are located in close proximity in the inner ear and any procedure in the cochlea may affect the vestibular system, resulting in subsequent balance impairment. in addition, the process of implantation often results in further suppression of vestibular function necessary to develop normal balance. vestibular dysfunction predisposes these children to balance impairments that can affect the normal development of gross motor skills such as sitting, standing, and walking. these balance and gross motor deficits may predispose the child to difficulties with safe community participation resulting in lower quality of life for the child and family. evidence in the literature suggests that children with vestibular loss do not recover to the same levels as their peers, especially in the area of activities requiring vestibular input for balance. the purpose of this descriptive study is to examine balance, vestibular function, and gross motor skills in children following cochlear implantation over a period of one year. children, ages 1 year to 5 years will be tested post cochlear implant , and at 6 and 12 months subsequent to initial testing, using clinically based tests of vestibular impairment (head impulse test, post rotary nystagmus or head shake nystagmus), balance (pediatric balance scale) and gross motor skill development (peabody developmental motor scales, 2nd edition). quality of life will be assessed using the life-h (assessment of life habits).


Eligibility criteria:
inclusion criteria: 1. the child must be a child between 12 months and 71 months of age. 2. the child should have received a cochlear implant within the previous year. 3. the child should be able to stand unsupported for 4 seconds. 4. follow simple one step directions. exclusion criteria: 1. uncontrolled seizures 2. any physician-recommended activity limitations that would preclude performing activities in the testing protocol. 3. testing will not occur when the child is or has been acutely ill (i.e. fever, ear infection, etc.) within the previous week. 4. the participant must not have a known medical or developmental diagnosis that impacts his or her motor skills (i.e. cerebral palsy, down syndrome) -
the influence by dietary human milk oligosaccharide in low birth weight infants

Conditions: Low Birth Weight Infants

Summary: this study aims to investigate the concentration of various growth factors and cytokines in blood, and to examine the gut microbiota of low birth weight infants fed with formulas with or without human milk oligosaccharide (hmo) supplement. eligible low birth weight infants are allocated to two groups, investigational formula (with hmo) or control formula (without hmo). the subjects are taking the assigned formula when they need to be supplemented with formula. after the informed consent was obtained and eligibility was confirmed, the intervention period begins, and ends at the one-month-old medical check-up with the assessment of the various blood growth factors and cytokines, and the gut microbiota.


Eligibility criteria:
1. inclusion criteria: 1-1) for infants i. low birth weight infants (defined as a birth weight ≥1,500 g and \<2,500 g) during hospitalization and may require milk powder formula as supplement. 1-2) for mothers i. mothers who do not find serious viral infection ii. mothers who are willing to provide consent for provision of study required information and specimen(s) from both mothers and infants iii. mothers who are willing to provide consent as infant's legally acceptable representative (lar) 2. exclusion criteria: 2-1) for infants i. infants who receive any formulas before informed consent. ii. infants with serious infections. iii. infants with necrotizing enteritis. iv. infants with gastrointestinal perforation. v. infants whom the pi determines inappropriate as a study subject (e.g. inflammatory, metabolic abnormalities and difficulty in enteral feeding). 2-2) for mothers i. mothers the pi determines inappropriate as a study subject ii. mothers under 18 years old. 3. withdrawal criteria: a subject must be discontinued from treatment with test formula if any of the following apply: i. if the mother, who is a subject of the study as well as infant's lar , asks for withdrawal from the study or withdraws consent. ii. when a serious adverse event occurs. iii. when an adverse event occurs, and the pi or co-investigator determines that the study should be discontinued. iv. if it is decided that there is a risk of compromising the safety of the study subject. v. if a subject is found to be ineligible after the start of the study. vi. if it is found that there is a serious or continued non-compliance with the study protocol by a study subject. vii. in addition, if the pi decides to end the study.
evaluation of gw406381 in treating adults with osteoarthritis of the knee

Conditions: Osteoarthritis, Knee

Summary: this study was designed to evaluate the effectiveness of gw406381 (a cox-2 inhibitor) in treating the signs and symptoms of osteoarthritis of the knee.

a phase iii, 12-week, multicentre, double-blind, double-dummy, randomised, placebo- and active comparator-controlled, parallel group study to investigate the efficacy and safety of gw406381 1mg, 5mg, 10mg, 25mg and 50mg administered orally once daily, in adults with osteoarthritis of the knee (cxa30007).

Eligibility criteria:
inclusion criteria: * subjects have a primary diagnosis of osteoarthritis of the knee with symptom duration of at least 3 months. * use pain medication, such as a cox-2 inhibitor or nsaid (non-steroidal anti-inflammatory drug) at least 5 days per week. exclusion criteria: * history of hypersensitivity or intolerance to pain medications. * history of gastroduodenal perforations and/or obstructions. * history of upper gi (gastrointestinal) ulceration within the previous 6 months. * history of upper or lower gi bleeding within the previous year. * history of inflammatory bowel disease. * currently take sucralfate or misoprostol. * currently taking aspirin daily for the heart. * other restrictions around the use medications apply and would need to be discussed. * history of coronary artery disease, (angina, mi) or surgery. * history of congestive heart failure or renal artery stenosis. * history of stroke or transient ischemic attack. * history of uncontrolled hypertension.

Keywords: cox-2 inhibitor knee osteoarthritis
feasibility of strength training in patients hospitalized due to copd

Conditions: COPD; Muscle Weakness

Summary: to examine the feasibility of progressive unilateral knee-extension strength training using ankle weight cuffs in patients hospitalized due to acute exacerbation in copd

we decided that feasibility is indicated if: 1) the absolute training loads increase progressively, 2) more than 80% of the planned training sessions are completed, and 3)if the absolute training loads do not exceed 20 kg (2 x10kg weight cuffs) for 90% of patients.

Eligibility criteria:
inclusion criteria: * have a primary diagnosis of copd * be admitted to the pulmonary ward due to an exacerbation in copd * provide informed consent to participation in the study * be able to maintain an upright position on a chair * be able to be guided to training and understand instructions for participating exclusion criteria: patients suffering from diseases that prevents the use of wrist weights such as * deep venous thrombosis (dvt) * erysipelas * painful edema of the limbs * lack of ability to walk, habitually * predicted hospital stay of less than four days as predicted by a pulmonary physician * patients admitted friday night or saturday morning cannot be stared up within 24 hours of admittance

Keywords: copd acute exacerbation physiotherapy resistance training muscle strength handheld dynamometer
thalidomide maintenance treatment in dlbcl

Conditions: Lymphoma, Large B-Cell, Diffuse

Summary: this is a randomized, multi-center,phase iii study to evaluate the ability of thalidomide maintenance therapy to prolong relapse-free survival in diffuse large b cell lymphoma(dlbcl).

this is a randomized, phase iii study to evaluate the ability of thalidomide maintenance therapy to prolong relapse-free survival(rfs), in diffuse large b cell lymphoma(dlbcl).patients will be enrolled after successful standard induction therapy (cr or cru following standard r-chop-like therapy with 8 infusions of rituximab plus chop-like chemotherapy (4-8 cycles). patients will be followed until an event occurs as defined in the protocol. to evaluate the clinical efficacy of thalidomide maintenance therapy as compared to observation in patients with dlbcl who have achieved a complete remission after appropriate first-line therapy, measured by rfs, 226 patients with dlcbl will be recruited.

Eligibility criteria:
inclusion criteria: * nccn-ipi\>1, * known ipi, cell of origin and dhl at time of diagnosis, * negative pregnancy test, * men must agree not to father a child during the therapy, * 6 to 8 cycles r-chop/like, total of 8 x rituximab, * cr, cru exclusion criteria: * transformed lymphoma, * secondary malignancy, * hiv positive, * evidence of cns involvement, * cardiac dysfunction (systolic ejection fraction \<50%), * creatinine \> 2.0 mg/dl

Keywords: diffuse large b-cell lymphoma thalidomide maintenance
reduction of risk for cardiovascular diseases

Conditions: Cardiovascular Diseases

Summary: to establish and evaluate a new prediction model for assessing cardiovascular disease risk in community-dwelling adults.

this is an ambispective, observational cohort study. in the retrospective part, we will enroll residents from guangzhou or foshan who participated in the annual health checks provided by the chinese national basic public health service project between january 2015 and december 2019. the demographic characteristics, anthropometric measurements, laboratory assays, medical history, living habits, and medications will be collected through personal electronic health records obtained from the regional chronic disease management platform. in the prospective part, residents who participated in the annual health checks provided by the chinese national basic public health service project after january 2020 will be enrolled. in addition to the data collected in the retrospective part, blood, urine and fecal samples and lifestyle questionnaires will be collected for further analysis. all participants will be followed-up till december 2025. a new prediction model for assessing cardiovascular disease risk will be established and evaluated.

Eligibility criteria:
inclusion criteria: * meet at least one of the following conditions: 1. age ≥ 65 years; 2. diabetes mellitus; 3. hypertension; exclusion criteria: * refuse to provide informed consent;

Keywords: cardiovascular diseases prediction model community
virtual reality on the imc

Conditions: Feasibility of Virtual Reality Stimulation for Critically Ill Patients

Summary: the goal of this substudy (main study nct04498585) is to determine the feasibility of applying virtual reality stimulation to patients in the intermediate care unit. patients on this ward are generally more awake and alert than patients in the intensive care unit, thereby they are able to provide feedback about their experience. as the intermediate care unit is not without stress, examining the physiological parameters (e.g., heart rate, respiration rate, blood pressure, etc.) could also provide telling information as to the calming effect of virtual reality. the movements of these patients are also recorded using accelerometers which will provide valuable information about the characteristics of the movements that patients make while confined to their beds. these movements can act as a reference for further investigation into movements related to delirium which is a secondary outcome measure of the main study.


Eligibility criteria:
inclusion criteria: * written informed consent * aged ≥18 years * no severe visual or auditory impairments (strabismus, macular degeneration, retinopathy) * german or french speaking * estimated length of stay (from time of study inclusion) \>24 hours exclusion criteria: * patients without calotte, with external ventricular drainage or other intracranial pressure probes * patients with epilepsy * patients with covid-19

Keywords: virtual reality intermediate care unit critical care movement analysis
improving the school vaccination experience: what cards are you going to play?

Conditions: Vaccine Adverse Reaction; Vaccination; Complications; Fear

Summary: vaccination hesitancy is identified as a threat to global health by the world health organization (who). for adolescents undergoing vaccination at school, prior studies demonstrate that concerns about pain and/or fear of needles contribute to negative experiences with vaccination and non-compliance with vaccination. the investigators developed an intervention that addresses vaccination hesitancy. in this study, investigators will evaluate the effectiveness of this intervention in a randomized controlled trial.

vaccination hesitancy is identified by the world health organization (who) as one of ten threats to global health. the who's 3c model of vaccination hesitancy identifies 3 domains of vaccine hesitancy: 1) confidence (trust in health care providers), 2) complacency (perceived importance of vaccine-preventable disease) and 3) convenience (improving clinic processes). the investigators developed a multifaceted knowledge translation intervention that addresses vaccination hesitancy in school-based vaccinations. the intervention is called the card(tm) system (c-comfort, a-ask, r-relax, d-distract). card is a framework for delivering vaccinations that is student-centred and promotes coping. card integrates evidence-based interventions related to planning and execution of school vaccination clinics to directly tackle all 3 domains of vaccination hesitancy. it tackles confidence by improving pain/fear management (it teaches students and public health staff how to reduce student symptoms which improves the vaccination experience and improves student trust in health care providers). it tackles complacency by educating students about what vaccines are, why they are needed, community immunity, as well as the specific diseases they are being protected against. it tackles convenience by improving school-based clinic processes by integrating student preferences (e.g., privacy, having a support person present). in this randomized controlled trial, the investigators will evaluate the impact of card (vs. usual care) on student important outcomes and process outcomes.

Eligibility criteria:
inclusion criteria: * grade 7 students eligible for vaccination at school * public health staff working in the school vaccination program exclusion criteria: * unable to understand and read english

Keywords: school vaccinations pain management vaccination hesitancy knowledge translation
effectiveness of exercises in patient with diabetic peripheral neuropathy

Conditions: Diabetic Peripheral Neuropathy

Summary: diabetic peripheral neuropathy (dpn) is the common complication seen in the diabetic patients. moreover, it will lead to another complication as disabilities and difficulties in activities of daily living (adl). most of the intervention for diabetes and diabetic neuropathic patients are mostly focusing on the prevention of foot ulcer. diabetic foot care can prevent only for diabetes-related foot ulcer and foot amputation. it cannot be reduced dpn and cannot be improved the activities of daily living of the patient with dpn. moreover, there is the restriction of weight-bearing exercise on the recommendation of exercises for the patients with dpn. therefore, exercise program which may be suitable for all the patients with dpn was introduced in this study to improve adl and decrease the neuropathic symptoms in the diabetic patients. compliance with exercise or intervention is not only critical to get adherence but also for the long-term use of its. easy to do exercise in the short duration which can able to do on their own in their home promote their compliance and adherence to the exercises. in this study, the effectiveness of exercises in the patients with diabetic peripheral neuropathy was examined to fulfill the requirement of exercises which is simple and can be done in a short time. the objective of the study is to examine the effectiveness of exercise in the patients with diabetic peripheral neuropathy.


Eligibility criteria:
inclusion criteria: * the patients receiving diabetic care at the out-patient-department of designated hospitals, able to contact via the telephone, presence of signs and symptoms of dpn, agreed to involve in the study (informed consent), and aged over 25 years exclusion criteria: * the persons who are suffering from dpn other than diabetes, severe illness of diabetic patients, diabetes with other comorbidities, amputation of hands and feet from any reasons, mental illness and alcoholism

Keywords: diabetic peripheral neuropathy, exercises
impact of a sleep debt in middle-aged and older adults

Conditions: Sleep Restriction

Summary: this project has 6 aims. 1. to examine the impact of recurrent partial sleep loss in young, middle-aged and older men and women. sleep will be restricted to 4 hours. 2. to test the hypothesis that extending bedtimes to allow for sleep recovery will reverse the metabolic, endocrine, and cardiovascular and neuro-behavioral alterations resulting from sleep restriction. sleep will be extended to 12 hours following the 4 hour sleep restriction. 3. to test the hypothesis that there are age and gender differences in the total amount of sleep recovery obtained during the week of 12-hour bedtimes. 4. to test the hypothesis that there are age and gender differences in sleep capacity (the amount of time an individual can sleep per night when there is no sleep debt). 5. to test the hypothesis that sleep capacity is partly determined by baseline levels of slow-wave sleep and slow-wave activity. 6. to determine whether sleep capacity is related to sleep need by examining metabolic, endocrine, cardiovascular and neuro-behavioral changes with the amount of the individual sleep debt.


Eligibility criteria:
inclusion criteria: * normal weight * healthy * age 18-75 old exclusion criteria: * sleep disorder * irregular life habits (shift workers, travelers) * smokers * on medication * consumption of \> 2 alcohol or caffeinated beverages/day

Keywords: sleep young adults middle-age adults older adults
standardization of ambulance equipment

Conditions: Safety Issues

Summary: the aim of the research is to find out what effect the standardization of ambulance equipment has on the speed of performing specific medical procedures.

the aim of the research is to find out what effect the standardization of ambulance equipment has on the speed of performing specific medical procedures. in two simulated scenarios, the times from the decision to execution of medical procedures will be measured. in the first scenario, the equipment is located in the standard way and the research participants know where it is located. in the second scenario, the equipment is placed elsewhere and participants do not have the opportunity to check the equipment before the scenario. for the statistical comparison the student's t-test and wilcoxon signed-rank test will be used. for analysis of variance will be used the anova test and for more than two dependent selections the friedman's anova test will be used.

Eligibility criteria:
inclusion criteria: * consent to participate * times of all procedures recorded * all procedures provided in a correct way - in meaning of quality of the procedure exclusion criteria: * disagreement with participation * not all procedures provided or not provided correctly

Keywords: quality and safety emergency medical services paramedics equipment standardisation