Kornimate/medical-research-clean huggingface dataset:
study of the carbon dioxide treatment for fat reduction

Conditions: Overweight

Summary: the primary objective of this study is to demonstrate the efficacy and safety of the carbon dioxide for subcutaneous fat reduction.


Eligibility criteria:
inclusion criteria: * male or female subject ages ≥ 18 years old * body mass index (bmi) between 18.5-24.99. (bmi is defined as weight in pounds multiplied by 703 divided by the square of the height in inches). subject in good health * willing and able to abstain from partaking in any treatment other than the study procedure (existing or new) to promote body contouring and/or weight loss during the course of study participation. * subject agrees to maintain their weight (i.e. within 5 pounds) by not making any changes to diet or lifestyle during the study. * the subject has the willingness and the ability to understand and provide informed consent for the use of their tissue and communicate with the investigator exclusion criteria: * pregnant or lactating or intends to become pregnant in the next 9 months. * unable to understand the protocol or to give informed consent * any previous and/or pending procedures at the treatment area or that may likely affect the treatment area * pending and/or anticipated major change in diet or exercise pattern in the six weeks following the last treatment or who has taken diet pills within the last 6 months. * history of asthma or chronic obstructive pulmonary diseases * active skin disease or skin infection in the treatment area * bleeding tendency or coagulopathy * subject who are allergic to lidocaine * any other condition that would, in the professional opinion of the investigator, potentially affect response or participation in the clinical study, or would pose as an unacceptable risk to the subject

Keywords: bmi classification-overweight
exercise training and kidney transplantation

Conditions: Solid Organ Transplant Rejection; Chronic Kidney Failure; Quality of Life; Inflammation; Muscle Weakness

Summary: the goal of this clinical trial is to investigate the physiological and molecular effects of exercise training in transplant recipients. the main questions it aims to answer are: 1. can exercise training improve physical fitness and muscle strength in transplant recipients? 2. can exercise training modulate inflammatory profile, hormones, lipid profile, and exercise-induced molecules in transplant recipients? 3. can exercise training improve blood pressure and endothelial health in transplant patients? participants will be invited to an exercise training program 6-month after their transplant surgery. body composition, physical assessment, and blood draw will be assessed at baseline and 12-weeks after exercise or control regimen. researchers will compare exercise group vs. routine care group to see if exercise training impact the health-related outcomes of this population.

the study will involve inviting participants to join an exercise training program six months after their transplant surgery. the research will include baseline assessments and measurements, such as body composition, physical assessment, and blood draws. these assessments will be conducted both at the beginning of the study and 12 weeks after participants have undergone either the exercise regimen or a control regimen. the research team will compare two groups: the exercise group and the routine care group. the goal is to examine whether participating in an exercise training program has a significant impact on various health-related outcomes in transplant recipients when compared to individuals receiving standard care. this clinical trial seeks to understand the potential benefits of exercise training on physical fitness, quality of life, inflammatory and molecular profiles, as well as cardiovascular health in individuals who have undergone organ transplantation. the comparison between the exercise group and the routine care group will provide valuable insights into the effectiveness of exercise interventions for this specific population.

Eligibility criteria:
inclusion criteria: * medical authorization: * stable health status * medication consistency * no history of severe cardiovascular events * no major orthopedic issues * non-smokers or consistent smoking habits * ability to comply with study protocols exclusion criteria: * inability to comply * cognitive disorders * unwillingness to continue * unstable health conditions * physical limitations during the protocol

Keywords: exercise training nephrology transplantation chronic kidney disease exercise physiology quality of life
mirror therapy versus task oriented training on hand function in children with unilateral cerebral palsy

Conditions: Unilateral Cerebral Palsy

Summary: the purpose of the study is to compare the effect between mirror therapy and task-oriented training on hand function in children with unilateral cerebral palsy.

dysfunction in the upper limbs and hand function is one of the most common symptoms in children with cerebral palsy (cp), particularly children with unilateral cp which intern has the potential to limit the involvement of these children in life activities and cause distress and suffering for both children and their parents. different rehabilitation intervention procedures addressing upper extremity dysfunction are essential to promote better use of disabled arms and hands in daily activities and achieving functional independence at home, in school and in the community. however, there is little evidence directed toward which intervention procedure is more effective on hand function therefore, there is need to compare between the functional outcome of mirror therapy versus task-oriented training on hand function in children with unilateral cerebral palsy.

Eligibility criteria:
inclusion criteria: 1. children ages will be ranged from 5 to 8 years old. 2. wrist flexor spasticity ranged from grade 1 to 1+ according to modified aswarth scale. 3. capacity to handle objects without continuous assistance (level i or ii in accordance with the manual ability classification system). 4. ability to sit alone. 5. sufficient cognition to follow simple verbal instructions. exclusion criteria: 1. fixed contracture or deformities in the upper limb. 2. visual or auditory defects. 3. botulinuim toxin injection in the last 6 months before the study. 4. previous surgical intervention in the upper limb.

Keywords: mirror therapy task oriented training hand function unilateral cerebral palsy
the analgesic efficacy of local anaesthetic wound infiltration versus intrathecal morphine for total knee replacement

Conditions: Total Knee Replacement

Summary: total knee replacement (tkr) is associated postoperatively with considerable pain and analgesic requirement. total knee replacement is routinely performed under spinal anaesthesia with intrathecal bupivacaine plus preservative free morphine. we hypothesize that infiltration of the surgical site with peri- and intraarticular levobupivacaine local anaesthetic would be an efficacious pain management technique and would not be inferior to intrathecal morphine for postoperative pain management. we further hypothesize that the use of this surgical site infiltration technique would decrease post-operative systemic opioid requirements as well as the side effects associated with intrathecal and systemic opioids.


Eligibility criteria:
inclusion criteria: * patients scheduled for unilateral total knee replacement * consent to spinal anaesthesia * asa grade i to iii exclusion criteria: * patient refusal * mini-mental score \< 25 (see appendix 3) * allergy to bupivacaine, morphine, paracetamol, diclofenac * skin lesions/infection at site of injection * uncorrected renal dysfunction * coagulation disorders * chronic pain condition other than knee pain

Keywords: total knee arthroplasty total knee replacement local infiltration analgesia intra-articular local anaesthesia patients undergoing total knee arthroplasty (total knee replacement)
active surveillance reporting to identify adverse events following chiropractic care in older adults

Conditions: Musculoskeletal Pain; Musculoskeletal Symptoms

Summary: in canada, almost 19% of chiropractic patients are aged over 65 years. although most of patients ≥65 years seek care for musculoskeletal conditions (such as back, neck and lower limb pain), there is inadequate prospective data on the safety of chiropractic care for these patients and the frequency of potential associated adverse events remains unknown. our study will investigate changes in symptoms reported by older adults receiving chiropractic care, with a focus on safety.

rationale: musculoskeletal conditions are more common and more severe in older adults than in younger adults and have a negative effect on their overall health-related quality-of-life by decreasing mobility, reducing social participation and causing substantial difficulties with activities of daily living. canada's population is rapidly aging and the socioeconomic burden associated with these conditions will continue to escalate. indeed, older patients (≥65 years) account for 18.8% of a chiropractor's case load. given the high proportion of older adults as chiropractic patients, research on the safety of chiropractic care for this population is critical. previous studies have reported adverse events (aes) following specific chiropractic techniques or as secondary outcome measures in older adults; however, there has been no attempt to prospectively capture changes in symptoms (and specifically aes). purpose: to: 1) calculate the frequency of aes reported by older adults following chiropractic care with an active surveillance reporting system; and 2) explore patient and provider factors related to changes in symptom (e.g., new, worsening, improving) following chiropractic care. more specifically, this study will use active surveillance reporting system to track the change in symptoms experienced by older adult patients after a chiropractic visit, in comparison to before. these symptoms can be pain, stiffness, fatigue, weakness, dizziness, nausea, etc. as active surveillances track the change in all symptoms experienced by all patients in a participating clinic, no specific condition/disease is being studied, but how the symptoms experienced by older adults seeking chiropractic care for a musculoskeletal condition (such as low back, neck, hip, should pain) change.

Eligibility criteria:
inclusion criteria: * older adults (≥65 years) seeking chiropractic care exclusion criteria: * diagnosed with cognitive decline (e.g. alzheimer's disease, dementia), acute infections, unable to read english and no access to email.

Keywords: older adult adverse event patient safety
validation of software for assessment of atrial fibrillation from ppg data acquired by a wearable smartwatch

Conditions: Atrial Fibrillation

Summary: validate the fitbit ppg rhythmdetect software system algorithm for providing notifications by identifying rhythms suggestive of atrial fibrillation or atrial flutter events.


Eligibility criteria:
inclusion criteria: * adults 22 years of age or older * capable of giving informed consent * u.s. resident * no prior history of atrial fibrillation or atrial flutter * fitbit account, with one of the following devices paired: * ionic, versa, versa lite, versa 2, versa 3, charge 3, charge 4, inspire hr, inspire 2, or sense updated to the latest available firmware. exclusion criteria: * diagnosis or history of atrial fibrillation at time of consent * diagnosis or history of atrial flutter at time of consent * current use of anticoagulation medication * cardiac pacemaker or implantable cardioverter-defibrillator
management of pericarditis in children.

Conditions: Pericarditis

Summary: the pericardium is a double-walled sac containing the heart and the roots of the great vessels. the pericardial sac has two layers, a serous visceral l layer (also known as epicardium when it comes into contact with the myocardium) and a fibrous parietal layer. it encloses the pericardial cavity, which contains pericardial fluid. the pericardium fixes the heart to the mediastinum, gives protection against infection and provides lubrication for the heart. pericardial diseases may be either isolated disease or part of a systemic disease diseases of the pericardium present clinically in one of several ways * acute and recurrent pericarditis * pericardial effusion without major hemodynamic compromise * cardiac tamponade with cardiac compromise * constrictive pericarditis

* pericarditis usually present with chest pain and dyspnea. effusion can present with no symptoms, dull ache in left chest and abdominal pain cardiac tamponade is recognized by the excessive fall of systolic blood pressure * diagnostic workup a) chest x-ray:_ chest x-ray can detect varying degree of cardiomegaly. b) echocardiography: it is the first-line imaging test. clinically, two-dimensional echocardiography with doppler provides the most cost-effective way of diagnosing c) electrocardiograph d) cardiac computerized tomography :- also may be helpful 4)therapy of pericarditis in pediatrics the medical lines of treatment of pericarditis are:_ a)aspirin and non-steroidal anti-inflammatory:_ are the mainstay of the therapy of inflammatory pericardial diseases b)steroids: a minority of patients will require treatment with systemic steroid therapy as * patients with symptoms refractory to standard therapy * acute pericarditis due to connective tissue disease ●uremic pericarditis c)immunosuppressant and biological drugs (more commonly used in recurrent pericarditis) .interventional therapeutic techniques-_ most patients with acute pericarditis can be managed effectively with medical therapy alone. however, patients may require invasive therapies for: * a moderate to large pericardial effusion, particularly if hemodynamically significant. * frequent, highly symptomatic recurrences of acute pericarditis with pericardial effusion ●evidence of constrictive pericarditis (a late occurrence when present) a)pericardial drainage :prolonged catheter drainage of a pericardial effusion is an effective means of preventing fluid reaccumulation. b)pericardiotomy, pericardial window and pericardiectomy: pericardiectomy may be considered for frequent and highly symptomatic recurrences of pericarditis tamponade .. c)surgical decompression of the pericardium :_can be achieved either by conventional heart surgery or video-assisted thoracoscopy.

Eligibility criteria:
inclusion criteria: * children with pericarditis and/or pericardial effusion above one year of age detected clinically and by echocardiography exclusion criteria: * children below one year of age. - children with malignant effusion.
comparative evaluation of partial and complete pulpotomy in permanent molars

Conditions: Pulpitis - Irreversible

Summary: this study will compare the outcome of partial pulpotomy and complete pulpotomy in mature permanent molars with clinical signs indicative of irreversible pulpitis

after thorough history and clinical and radio graphic examination, and confirmation of eligibility for the study, written informed consent will be taken after explaining the procedure and its associated risks and benefits. clinical diagnosis of irreversible pulpitis will be established based on a history of spontaneous pain or pain exacerbated by cold stimuli and lasting for a few seconds to several hours (lingering pain) compared to control teeth and which is reproducible using cold testing. once included, study subjects will be randomly allocated to either complete pulpotomy group or partial pulpotomy group. (mineral trioxide aggregate) mta will be used as pulpotomy agent. a layer of resin modified glass ionomer liner will be placed over the mta and tooth will be permanently restored with composite resin in second appointment. pain analysis will be carried out preoperatively and postoperatively at every 24 hours till 7 days after intervention. all the subjects will be followed up for evaluation of success at every 3 months from baseline to 1 year.

Eligibility criteria:
inclusion criteria: inclusion criteria * the patient should be ≥18 years of age. * restorable molar teeth. * tooth should give positive response to pulp sensibility testing. * clinical diagnosis of irreversible pulpitis. * tooth with probing pocket depth and mobility are within normal limits. * no signs of pulpal necrosis including sinus tract or swelling. * non-contributory medical history exclusion criteria: * teeth with immature roots. * no pulp exposure after caries excavation. * bleeding could not be controlled in 6 minutes. * insufficient bleeding after pulp exposure, the pulp is judged necrotic or partially necrotic.

Keywords: irreversible pulpitis complete pulpotomy partial pulpotomy vital pulp therapy
pilot study of topical steroid for prevention of chronic lung disease in extremely premature infants.

Conditions: Bronchopulmonary Dysplasia

Summary: a pilot study to evaluate the safety and the efficacy of endotracheal instillation of pulmonary surfactant, with or without topical steroid (budesonide), as a prophylactic treatment for bronchopulmonary dysplasia (a form of chronic lung disease) in extremely low birth weight infants. cytokines (a group of inflammatory mediators) are measured in the tracheal aspirate before and after instillation of the study drugs.

bronchopulmonary dysplasia (bpd) is still one of the most common complications of ventilated premature infants. lung inflammation plays a major role in its pathogenesis. systemic steroids can be given to control this inflammatory process but their widespread use is limited by their systemic side effects and concerns for long neurodevelopmental adverse sequelae. delivering steroids by inhalation which has been proven to be effective in young infants with asthma has been shown to be unsatisfactory for elbw infants with bpd. this may be due to the fact that current delivery devices do not meet the requirements of the specific anatomical and physiologic characteristics of the airways and breathing patterns in this special group of patients. a novel approach to facilitate delivery directly to the lungs, thereby avoiding systemic concerns has been demonstrated in a recent study in which budesonide ( a topical steroid) was given to ventilated preterm infants using surfactant as a vehicle.

Eligibility criteria:
inclusion criteria: 1. birth weight 501-1000 g and ≤ 28 weeks gestational age 2. diagnosed as rds requiring mechanical ventilation and surfactant therapy during the first 4 hours after birth 3. still ventilated on day 5-9 of life. 4. an interval of at least 24 hours' duration between the last dose of indomethacin and the endotracheal instillation of study drug. exclusion criteria: 1. congenital or chromosomal anomalies 2. occurrence of perinatal sepsis 3. use of intravenous steroids \> 7 days

Keywords: bronchopulmonary dysplasia budesonide infasurf
evaluation of the efficacy and safety of an equimolar mixture of oxygen and nitrous oxide in external cephalic version (ecv)

Conditions: Breech Presentation in Pregnancy

Summary: the variety of breech presentation at term is about 3-4% of all births. our study aims to assess the value of using an equimolar mixture of oxygen and nitrous oxide. indeed, in some patients algic or relaxed, the success rate seems more important. it's a single blind prospective randomized controlled study, comparing success rate of ecv after an equimolar mixture of oxygen and nitrous oxide or placebo (medical air). we need to include 150 patients (75 in each arm), for a period of 2 years. after ecv, we will give the patient a satisfaction questionnaire. we compare the success rate of ecv as primary outcome.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * pregnancy at term (≥36 weeks) * singleton foetus in breech or transverse presentation * acceptance of ecv * signature of informed consent exclusion criteria: * contraindications of ecv: placenta praevia, obstacle praevia, multiple pregnancy, foetal death, foetal heart rhythm disorder, lack of amniotic fluid, hiv-positive patient * contraindications of equimolar mixture of oxygen and nitrous oxide : patient who require pure oxygen ventilation, disorders of consciousness that impede the cooperation of the patient, pneumothorax, pulmonary embolism, ocular surgery

Keywords: breech presentation equimolar mixture of oxygen and nitrous oxide external cephalic version
tcd followed by autosct for newly diagnosed mm patients

Conditions: Multiple Myeloma

Summary: multiple myeloma is a incurable disease. thalidomide in combination with other agents are currently in trials for the newly diagnosed patients, we designed treatment of tcd, followed by high dose chemotherapy with autologous stem cell transplantation and td maintenance therapy for the patients with newly diagnosed multiple myeloma.

phase ii clinical trial for the patients with newly diagnosed. tcd (thalidomide, cyclophosphamide and dexamethasone) will be applied for the patients as an induction chemotherapy, followed by high dose chemotherpy and autologous stem cell transplantation. afterthen, they will receive td (thalidomide and dexamethasone) maintenance therapy for one year.

Eligibility criteria:
inclusion criteria:newly diagnosed multiple myeloma in aged between 18 and 75 years old with following mesurable leisons: (serum m-protein ≥ 1 g/dl or urine m-protein ≥ 400 mg/day) - exclusion criteria: - 1. smoldering or indolent myeloma 2. ecog performance status \> 3 point 3. known hypersensitivity to cyclphosphamide, thalidomide or dexamethasone 4. peripheral neuropathy or neuropathic pain grade 2 or higher as defined by nci ctcae version 3 5. uncontrolled or severe cardiovascular disease, including mi within 6 months of enrolment, new york heart association (nyha) class iii or iv heart failure, uncontrolled angina, clinically significant pericardial disease, or cardiac amyloidosis, cardiac ejection fraction \<0.5 : severe conduction disorder : hypotension (sitting systolic bp ≤ 100 mmhg and/or sitting diastolic bp ≤ 60 mmhg 6. impaired hepatic function (ast or alt ≥ x 3 upper normal, t-bilirubin ≥ x 2 upper normal) 7. creatinine cliearance \< 20 ml/min 8. corrected serum calcium ≥ 14 mg/dl 9. sepsis or current active infection 10. pregnancy or breast feeding 11. uncontrolled diabetes mellitus 12. previous history of recurrent dvt or pulmonary embolism 13. active ulcers detected by gastroscopy 14. serious medical or psychiatric illness likely to interfere with participation in this clinical study. 15. receipt of extensive radiation therapy within 4 weeks