Kornimate/medical-research-clean huggingface dataset:
endoscopic ultrasound (eus) intratumoral injection of car-nk cells in the treatment of advanced pancreatic cancer

Conditions: Pancreatic Cancer Non-resectable

Summary: this is a single-center, single-arm, open-label, dose-escalation clinical study to evaluate the safety and anti-tumor efficacy of intratumoral nkg2d car-nk cell injection guided by endoscopic ultrasound in the treatment of locally advanced pancreatic cancer.


Eligibility criteria:
inclusion criteria: 1. 18\~75 years old (including boundary value), both male and female. 2. histologically or cytologically confirmed pancreatic ductal adenocarcinoma or ipmn carcinogenesis. 3. recurrent or unresectable locally advanced pancreatic cancer. patients with technically resectable tumors but are considered as unable to undergo surgical treatment due to medical comorbidities or the patient\&#39;s refusal of surgery are also eligible for enrollment. 4. ecog ps score of 0-1. 5. at least 3 months of life expectancy at screening, as judged by the investigator. 6. subject has adequate organ and bone marrow function. laboratory screening results should be within the stable range described below, and there should be no ongoing supportive care (\&#34;jaundice relieve\&#34; therapy such as ptcd, enbd, or bile duct stenting is allowed when pancreatic cancer invades the common bile duct). a) blood biochemistry: serum creatinine ≤ 1.5×uln, serum total bilirubin ≤ 2.0×uln, and serum liver aminotransferase ≤ 3 ×uln b) blood tests: neutrophil count ≥ 1.5×109/l, platelet count ≥ 60×109/l, hemoglobin ≥ 8.0g/dl, lymphocyte count ≥ 0.4×109/l; 7. childbearing status: not pregnant and, if of childbearing potential, willing to use effective contraception from the time of signing the informed consent form until 6 months after the last cell infusion (women of childbearing potential include premenopausal women and women within 2 years of postmenopausal time). 8. subjects must sign a written informed consent form. 9. subjects must be voluntary and able to comply with the scheduled treatment regimen, laboratory tests, follow-up, and other study requirements. exclusion criteria: 1. pregnant and lactating females. 2. received any anti-tumor therapy (including but not limited to radiotherapy, chemotherapy, or immunotherapy) for pancreatic cancer within 28 days prior to enrollment. 3. in the opinion of the investigator, the eus technique poses undue risks to the subject, including but not limited to: - previous eus-fna was technically deemed too difficult to perform; - imaging showing multiple collateral vessels around or near the target tumor within the pancreas; - presence of varicose veins near the target tumor. - if any of the above risk profiles become apparent after subject screening and/or enrollment, consideration should be given to withdrawal from the study prior to treatment. 4. history of malignancy within 5 years, with the exception of basal cell carcinoma of the skin and carcinoma in situ of the cervix. 5. any other health condition by the judgment of the investigator would preclude participation in the study.
evaluation of blood biomarkers as an indicator of postoperative cognitive dysfunction

Conditions: Postoperative Cognitive Dysfunction

Summary: postoperative cognitive dysfunction is defined as a cognitive decline arising after surgery. in the present study, the authors evaluate the level of d-amino acid oxidase, d-serine and serine in blood as an indicator of postoperative cognitive dysfunction after cardiac surgery.


Eligibility criteria:
inclusion criteria: * patients scheduled for elective cardiac surgery exclusion criteria: * mmse \<24 * history of psychological or neurological diseases * illiteracy
long-term safety and efficacy of prebiotic enriched infant formula

Conditions: Infection; Microbial Colonization; Healthy

Summary: the primary objective of the present study was to evaluate the effects of long-term supplementation of an infant formula supplemented with prebiotic inulin-type oligosaccharides on immunological-health related outcomes.

the study primarily aimed to evaluate the effects of long-term supplementation of an infant formula with a mixture of short and long chain inulin-type oligosaccharides on immunological-health related outcomes, as well as on gastrointestinal function and well-being in infants during the first year of life. effects on infant growth, tolerance and on the composition of fecal microbiota were further objectives of this study. the study was conducted as a multicenter, randomised, double-blind, placebo-controlled study in healthy term infants. the two groups of the study are product group (standard infant formula supplemented with inulin-type fructans) and control group (non-supplemented standard infant formula).

Eligibility criteria:
inclusion criteria: * healthy babies born between 37 - 42 weeks of gestation and with weight appropriate for gestational age (between percentiles 3 and 97) * healthy babies aged between 0 - 4 months of age * babies exclusively fed with an infant formula on enrolment into the study exclusion criteria: * the presence of an infection at the moment of the recruitment or 1 week before recruitment * the presence of important pathologies (intestinal, cardiopathy, mental retardation, etc.) * any other diseases related to the immune system (primary immunodeficiency) * parents not able to comply with the study follow up (according to physician criteria)
correlation between voice pitch changes and tension of suboccipital muscles in normal subjects

Conditions: Voice Change; Suboccipital Muscles Tension

Summary: this study for investigation of correlation between voice pitch and tension of suboccipital muscles

participants will be assigned randomly , normal people i will use 2 instruments first : compturized speech lab (csl) to analyze voice pitch second: electromyography emg to measure suboccipital muscle tension during speech this task will be repated twice first one during normal speech , second one during change in voice pitch

Eligibility criteria:
inclusion criteria: * healthy adults aged 20-60 years. * no history of musculoskeletal disorders, voice disorders, or neurological conditions. * normal voice function (voice handicap index \[vhi\]-10 ≤ 11) . exclusion criteria: * individuals with neck pain or injury in the past six months. * history of vocal pathologies, recent surgeries, or auditory impairments

Keywords: voice pitch changes tension of suboccipital muscles correlational study
a sympathetic ganglion, high-voltage pulsed radiofrequency ablation of peripheral neuralgia

Conditions: Diabetic Foot

Summary: the sham operation group was used as control, the patients were assessed with the digital rating scale (nrs) , the quality of life-related scale (euro qol) , clinical outcome measures: physician's overall impression of changes in pain (cgic) and patient's overall impression change scale (pgic) , skin temperature measurement, toe oxygenation measurement, and anxiety and depression scores (gad-7, phq-9) , objective: to evaluate the efficacy and safety of high voltage pulsed radiofrequency in the treatment of peripheral neuralgia in patients with diabetic foot.


Eligibility criteria:
inclusion criteria: * subjects voluntarily participate in the study and sign the informed consent form; * the age is between 18 (inclusive) and 85 (inclusive), regardless of gender; * body mass index (bmi) ≤ 45; * clinically diagnosed diabetes foot with moderate and severe pain in peripheral nerve of affected limb (defined as nrs score ≥ 4), the course of disease lasts for more than 12 months, and has been treated with clinical routine standard drugs (mecobalamin α- lipoic acid, sodium valproate, carbamazepine, gabapentin/pregabalin, etc.) symptoms still exist at least 6 months later; * glycated hemoglobin\<8%; * not participating in the drug/medical device test within 3 months before the test; exclusion criteria: * patients who are in poor condition and cannot objectively describe symptoms or cooperate to complete the questionnaire score * ulcer is red and swollen, or active inflammatory infection; * the affected limb has lesions such as blackening and gangrene of the toe skin; * those suffering from severe respiratory and cardiovascular diseases, liver and kidney insufficiency, and malignant tumors; * breast-feeding and pregnant women, or subjects with pregnancy plan within 1 month after the trial (also including male subjects); * the daily dose of opioids is more than 120mg (different drug doses are converted into 120mg morphine sustained-release tablets); * people with allergic diseases and allergic constitution; * have a history of drug abuse or drug addiction; * there are contraindications to pulsed radio frequency therapy;
accelerated intermittent theta burst stimulation in unipolar versus bipolar depression

Conditions: Depressive Disorder

Summary: the goal of this interventional study is to learn if accelerated intermittent theta burst stimulation can improve symptoms of 30 participants with unipolar depression in higher manner than symptoms of 30 participants with bipolar depression

we will apply stimulatory tms protocol for participants with unipolar depression and participants with bipolar depression using magventure magpro r30 stimulator with the cool-b65 coil

Eligibility criteria:
inclusion criteria: * age:18_65 years * sex:male and female * patients with unipolar depression and bipolar depression diagnosis confirmed by scid according to dsm5 * no pharmacological change in the last 4 weeks before the beginning of the stimulantion cycle * pharmacological resistance exclusion criteria: * patients complaining of psychosis.substance use disorder.current suicidal ideation.major medical and neurological disorder * patients complaining of epilepsy * pregnancy and breastfeeding * peacemaker spinal or bladder stimulator * history of skull surgery and trauma * presence of metallic foreign body
sexual health empowerment for cervical health literacy and cancer prevention

Conditions: Cervical Cancer

Summary: the purpose of this study is to learn if a cervical health literacy program is a practical and helpful way of improving women's cervical health knowledge and improving cancer screening behaviors, and ultimately preventing cervical cancer.

women in the criminal just system are 4-5 times more likely to have cervical cancer than non-incarcerated women. little is known about how to close this gap. the few investigators that have studied cervical cancer risk and disease among women in jails and prisons have found that while many women get screened for cervical cancer, less than half get follow-up care. the investigator's pilot research suggests the most important contributor to cervical cancer risk, and perhaps lack of follow-up, is incarcerated women's low health literacy about both cervical cancer and broader reproductive health issues. this study is testing a sexual health empowerment intervention (she project) to see if it improves incarcerated women's reproductive health literacy.

Eligibility criteria:
inclusion criteria: * women sentenced or anticipate a sentence of one year or less * ability to follow participants post-jail release * able to read and understand english exclusion criteria: * women who have been treated for cervical cancer with procedures that would obviate the need for regular screening * exhibit severe psychological distress
hpv serum dna levels predicting outcome in p16+ squamous cell head and neck cancer

Conditions: Subjects With p16 Positive/HPV Positive Squamous Cell Carcinomas of the Oropharynx

Summary: to assess in an exploratory manner, the pronostic utility for locoregional control, progression-free and distant metastasis-free survival of a pre-therapy and post-therapy blood dna test of hpv e6 and e7 dna for subtypes 16 and 18 in p16+ and/or hpv+ oropharyngeal cancer patients. this will entail analysis of both initial pre-therapy hpv level as a continuous variable and initial post-therapy hpv level as a dichotomous variable.


Eligibility criteria:
inclusion criteria: * histoloically proven primary cancer of the oropharynx, p16(+) and/or hpv (+), who are planned for treatment with resection, radiation and/or chemotherapy. * subsites of oropharynx:include tonsil, base of tongue, vallecula, oropharyngeal wall, soft palate, glossotonsillar sulcus. * no or minimal smoking history (\</= 10 pack-year, no smoking in the past 12 months last 10 years based on documented history and/or subject report) * age 18 years or older * subjects are capable of giving informed consent or have an acceptabl;e surrogate capable of giving consent on the subjects behalf. * enrollment on any other study, regardless of therapy is allowed. * enrollment on any other tumor or tissue banking study is allowed. * patients who have had blood drawn as part of another study, including the irb-approved ent tumor bank study, may be included in this study even if the patient has already had surgery. exclusion criteria: * previous chemotherapy or radiation therapy to the head and neck unrelated to current disease. * previous surgery for head and neck cancer unrelated to current disease. * widespread , biopsy-proven metastatic disease (stage ivc disease) at time of presentation (small indeterminate lung or mediastinal nodules are allowed) * patients who have started induction chemotherapy prior to consideration for study eligibility. * another active cancer except nonmelanomatous skin cancer. * history of cervical penile or anal cancer. * patient treated with surgery, adjuvant radiation therapy or chemotherapy outside of the university of pennsylvania. * history of smoking in the past last 12 months 10 years * history of 10 pack-years of cigarette smoking based on documented history and/or subject report * presence of sidespread leukoplakia or erythroplakia.
quality of life 10 years after bariatric surgery

Conditions: Obesity

Summary: importance: improvement of the qol after bariatric surgery is an important outcome of the treatment. the investigators believe that assessment of distant qol results, could provide new insight into effectiveness of most popular bariatric procedures. objective: the investigators aim to analyze the bariatric surgery effect on the long term qol, considering the type of surgery. design: a cohort study including patients undergoing bariatric surgery. setting: one academic referral center. exposures: patients undergo laparoscopic sleeve gastrectomy or laparoscopic roux-en-y gastric bypass . surgical technique is standardized and consistent in the whole study group. main outcomes and measures: the main outcome is the change of qol after bariatric surgery. it is assessed in three different time points: pre-surgery, first follow up (1 year after surgery) and second follow-up (10 years after surgery). the investigators use two licensed and standardized questionnaires: (short form health survey) and ma-qolqii (moorehead-ardelt quality of life questionnaire ii).


Eligibility criteria:
inclusion criteria: * informed consent to participate in the study * meeting the eligibility criteria for bariatric treatment, either for laparoscopic sleeve gastrectomy (lsg) or laparoscopic roux-en-y gastric bypass (lrygb). exclusion criteria: * previous bariatric procedures
a multi-centre rct of the axium® neurostimulator for the treatment of chronic inguinal pain following surgery

Conditions: Chronic Inguinal Pain Refractory to Previous Surgical Intervention (Neurectomy)

Summary: 24-smi-2014 is a randomised controlled trial with an optional one way cross-over comparing conservative medical management (cmm) to treatment with the axium neurostimulator + cmm. subject population is chronic inguinal pain refractory to previous surgical intervention (neurectomy).


Eligibility criteria:
inclusion criteria: 1. subject is at least 18 years old 2. subject is able and willing to comply with the follow-up schedule and protocol 3. chronic inguinal pain following pfannenstiel incision or open inguinal hernia repair for at least 6 months 4. previously undergone neurectomy procedure as a treatment for chronic inguinal pain 5. minimum daily average baseline pain rating of 5 out of 10 in the inguinal area on an 11-point nprs 6. subject is able to provide written informed consent 7. meets of the inclusion criteria for the implantation of a neurostimulation system as set out by the dutch neuromodulation society 8. subject has been screened by a multi-disciplinary panel including the designated psychologist of the máxima medical center and deemed suitable for implantation exclusion criteria: 1. female subject of childbearing potential is pregnant/nursing or plans to become pregnant during the course of the trial 2. escalating or changing pain condition within the past month as evidenced by investigator examination 3. subject has had injection therapy or radiofrequency treatment of a target neural structure within the past 3 months 4. subject currently has an active implantable device including implantable cardioverter defibrillator, pacemaker, spinal cord stimulator or intrathecal drug pump 5. subject is unable to operate the device 6. subjects currently has an active infection 7. subject has participated in another clinical investigation within 30 days 8. subject has a coagulation disorder or uses anticoagulants that, in the opinion of the investigator, precludes participation 9. subject has a current or on going condition, which will probably require mri investigation sometime in the following 2 years 10. subject has had a spinal surgical procedure at or between vertebral levels t10-l2 11. subject has been diagnosed with cancer in the past 2 years, except for skin malignancies.
mobile observation of depression

Conditions: Major Depressive Disorder; Major Depressive Episode; Bipolar Disorder

Summary: the primary aim of this project is to test if ocosense glasses can function as a digital phenotyping tool derived from behavioural and physiological signals related to facial expression and motion recorded using the glasses.

assessment of participants living with a dsm5 research diagnosis of bipolar disorder or major depressive disorder as well as healthy controls who will be recruited and characterised through precision phenotyping involving cross-sectional assessment of biobehavioural and physiological markers of the symptoms of depression. correlations between objective (i.e., ocosense glasses captured) and subjective (i.e., self-reported) symptoms of depression will be measured within as well as across diagnoses. the resulting biobehavioral clusters will form the building block of a digital phenotyping tool based upon the wider spectrum of non-verbal behaviours and physiology defined and affected by the phenotype of depression.

Eligibility criteria:
inclusion criteria: all participants: * ability to read \& understand english. this is because the majority of our questionnaires are validated in the english language only. * able to walk, sit, lay and stand unaided clinical cases: ● ≥ 15 on the patient health questionnaire-9 (phq9) (moderate to severe depression) exclusion criteria: healthy control participants: * self-reported current or past history (suspected or diagnosed) of any psychiatric condition * \<5 on the generalised anxiety disorder-7 questionnaire (gad-7) * \<5 on the phq-9 (no depression) * receiving medication for any psychiatric disorder (excluding fibromyalgia) all participants: * \ 40 years of age * anatomical constraints that affect fit (e.g. facial disfigurement) * facial nerve damage which limits the ability to make facial expressions * body mass index (bmi) \>29.9 which we deem may affect physical mobility

Keywords: digital phenotyping emotion ocosense wearables multimodal
is intercostal tube enough in management of empyema

Conditions: Empyema

Summary: is intercostal tube enough in management of empyema ?

empyema refers to presence of pus in the pleural space -causes primary: bacterial pneumonia (staph aureus, strept pneumonia , h.influenza) , tb secondry : posttraumati postoperative :open heart , esophageal, mediastinum , lung rupture of lung absess -pathophysiology and stages during an inflammatory process such as pneumonia, there is an increase in fluid production in the pleural cavity known as the exudate stage. as the disease progresses microorganisms, usually bacteria, can colonize the fluid and generated an empyema. this fluid is characterized by elevated lactate dehydrogenase, proteins, neutrophils, and dead cells. macroscopically is a thick opaque fluid found in the fibrinopurulent stage. after the resolution of the infection and as a consequence of the inflammation, there is a process of fibrosis that can lead to restriction of the lung parenchyma which is stage of chronic organization

Eligibility criteria:
inclusion criteria: * patients admitted to assuit university hospital and diagnosed with empyema exclusion criteria: * patient diagnosed with post-operative empyema * patient diagnosed with post traumatic empyema * patient diagnosed with bronchopleural fistula * patient diagnosed with tb
implementing an ipts treatment approach to improve outcomes in suicidal youth

Conditions: Suicidal Ideation; Depression

Summary: the purpose of this project is to evaluate a set of interventions derived from a theory of suicide that supplements a clinical program and compare their effects on outcomes to the outcomes of the unsupplemented program. this study proposes to evaluate the effect of these interventions on reducing specific negative cognitions associated with depression and suicide ideation in an intensive outpatient program for suicidal youth (suicide prevention and resilience at children's, sparc).

the trial will be conducted in a program where half of the clients are enrolled into either the original program (sparc a which has a general focus on negative cognitions) or sparc b (which will overlap significantly with sparc a but targets in some sessions specific negative cognitions of perceived burdensomeness). the program is already structured so that each patient consistently attends either a morning or an afternoon track, with different therapists running each track. this allows for separate programs in each track. clinically justifiable innovations are routinely introduced into the program usually in a stepwise fashion in one or another part by one set of therapists at a time. the investigators propose to take advantage of this partial introduction by assessing relative impact of sparc a and sparc b on depressive symptoms and suicide ideation. the investigators have no data to indicate that one program will be better than the other. the investigation will, however, allow the investigators to assess whether this innovation in fact is effective. patients will not be randomized at the individual level, but rather their time slot (usually decided based on opening within the program) will place them into either sparc a or sparc b. the two programs are of identical length with numerous features in common, differing only in the specificity of the exercises and examples and their relevance to perceived burdensomeness. routine assessments at entry and discharge from the program will not change based on study enrollment. however, suicide ideation, depressive symptoms, and negative cognitions (perceived burdensomeness and thwarted belongingness) will be more formally assessed at the one-month follow-up meeting or phone call which will add approximately 10 minutes to the contact.

Eligibility criteria:
inclusion criteria: * adolescents, ages 12 - 17 * enrolled in the sparc program at children's medical center of dallas * completed at least 5 sparc group therapy sessions exclusion criteria: * adolescents who have previously received treatment in the control arm of the study