Kornimate/medical-research-clean huggingface dataset:
single port colic laparoscopic surgery

Conditions: Colonic Neoplasms; Crohn's Disease; Diverticulitis

Summary: this study aims to compare the results of colonic surgery performed by single and multiport laparoscopy.

the aim of this study is to compare surgical results of colonic resection performed by single port and multiport laparoscopic approaches. primary endpoint is the length of postoperative hospital stay. secondary endpoints include postoperative mortality, postoperative morbidity, conversion rates, postoperative recovery, aesthetic results, postoperative pain, and costs

Eligibility criteria:
inclusion criteria: * age ≥ 18 * colonic resection performed for benign or malignant colonic neoplasm, crohn's disease, or diverticulitis * informed consent signed * social insurance exclusion criteria: * digestive stoma in place or planned during the intervention * body mass index \> 30 kg/m2 * history of previous laparotomy, except mc burney, pfannenstiel ou subcostal * subtotal colectomy * transverse colectomy * proctectomy or total coloproctectomy * synchronous metastasis * preoperative suspicion of t4 colorectal cancer * emergency procedure * associated resection (except appendectomy or liver biopsy) * pregnancy or current breast feeding.

Keywords: single port surgery colonic surgery postoperative morbidity postoperative outcomes
mri compared to pet/ct for staging and treatment response in lymphoma

Conditions: Lymphoma

Summary: the lymph nodes or masses,positron emission tomography/computed tomography (pet/ct) standardized uptake values(suv) results, whole body magnetic resonance imaging(mri) intravoxel incoherent motion(ivim) sequence d, d\*, f values and mri volumes of lymphoma patients were compared before and after the chemotherapy in this project prospectively to provide data for evaluating the dependency and differences of pet/ct and whole body mri in lymphoma staging and therapeutic evaluation. long-term therapeutic effect indexes obtained in follow-up visits of patients such as overall survival(os), progression free survival (pfs) etc. were used to evaluate the diagnostic sensitivity and differences of mri and pet/ct. the research could provide a new method of nonionizing radiation iconography for physicians to give appropriate treatments and predict prognosis.


Eligibility criteria:
inclusion criteria: * lymphoma subtypes were diagnosed on the basis of tissue samples obtained by biopsy or surgery according to the criteria outlined in the current world health organization (who) classification of hematologic and lymphoid malignancies, by a reference pathologist. * patients who gave written informed consent were referred for dwi-mri and 18f-fdg-pet/ct. * stable physical medical conditions (patients conscious and comfortable, scheduled for an elective diagnostic imaging). exclusion criteria: * pregnancy, general contraindications to mri, and therapeutic interventions between dwi-mri and 18f-fdg-pet/ct were used.
radiographic assessment of bone gain following sinus lifting with simultaneous implant placement using crestal approach with membrane control technique for bone augmentation of atrophied maxillary posterior ridge

Conditions: Implant Site Reaction; Maxillary Deficiency

Summary: this study aims to evaluate the quantity and quality of the native and the newly bone around dental implants that's simultaneously installed with sinus lifting


Eligibility criteria:
inclusion criteria: 1. patients required dental implant treatment in the posterior maxilla, in the premolar and molar regions ( both sexes). 2. residual bone height 4-8mm in the estimated implant positions. 3. the bone width of the alveolar ridge is at least 5mm in estimated implant positions. 4. the edentulous ridges are covered with optimal thickness of mucoperiosteum. exclusion criteria: 1. patients with a systemically diseases or inflammation whether local or generalized. 2. patients with bleeding disorders. 3. subjected to irradiation in the head and neck area less than 1 year before implantation. 4. poor oral hygiene and motivation. 5. pregnant or nursing. 6. severe bruxism or clenching. 7. active infection or severe inflammation in the area intended for implant placement. 8. unable to open mouth sufficiently to accommodate the surgical tooling.

Keywords: closed sinus lifting bone gain
side effects of different treatment methods

Conditions: Root Resorption; Pain; Chewing Function

Summary: this study aimed to compare the effects of fixed orthodontic treatment and clear aligner therapy on root resorption, periodontal status, pain experience and chewing performance.

the aim of the study is to compare the potential side effects of fixed orthodontic treatment and clear aligner therapy. 27 individuals who were treated with clear aligners (20 female, 7 male; mean age: 22.57 ± 7.37) and 22 patients treated with braces (14 female, 8 male; mean age: 17.05 ± 4.51) formed the study group. the periodontal statuses of the patients(probing depth, bleeding on probing, plaque index) were evaluated before treatment (t0), 3 months (t1) after, and at 6th month (t2) following the beginning of the treatment. the amount of root resorption in maxillary \& mandibular incisors was evaluated on periapical radiographies taken with the paralleling technique. pain experience and chewing function were also recorded during treatment.

Eligibility criteria:
inclusion criteria: * patients treated with fixed braces or clear aligners * patients with mild to moderate crowding * patients without root canal treatment or resorption in anterior teeth * patients with completed root development * patients with good periodontal health at the beginning of the treatment * patients with no congenitally missing or impacted tooth. exclusion criteria: * history of orthodontic therapy * poor patient compliance * presence of any craniofacial syndrome or systemic disease * presence of cleft lip and palate * trauma history * mental retardation * use of oral antiseptic solutions during orthodontic treatment * need for scaling and root planning during treatment * clear aligner patients with delayed movement of the anterior teeth.

Keywords: root resorption pain chewing function fixed orthodontic treatment clear aligner therapy
plasmalyte-148 solution and blood coagulation

Conditions: Blood Coagulation Disorder

Summary: fluids administered intravenously may alter whole blood coagulation. however, little is known about the dose-response relationships of hemodilution in plasmalyte-148 solution. investigators have therefore performed the present study to measure the effect of a plasmalyte-148 solution on the coagulation pathway according to the hemodilution level using a rotational thromboelastometry (rotem®) tests.


Eligibility criteria:
inclusion criteria: * healthy volunteers * age: 20 to 65 years * body weight \> 50 kg * volunteers who provided informed consent exclusion criteria: * hematologic disease * anticoagulant medication
prospective study of exercise regimens after treatment for breast cancer for hypertrophy and conditioning

Conditions: Cancer; Breast Cancer

Summary: this study investigates the impact of four standard of care, monitored group exercise regimens (resistance training) on conditioning and hypertrophy in women previously treated for breast cancer. the study will compare two conditioning regimens (6-12-25 and 8x8) and two hypertrophy regimens (5/5/5 cluster sets and double training) to assess changes in vo2 max, muscle mass, and fat mass.


Eligibility criteria:
inclusion criteria: 1. age 20-89 years 2. women prescribed exercise as a standard of care 3. women with a biopsy proven diagnosis of ductal carcinoma in situ (dcis) or invasive carcinoma of the breast 4. women must have undergone treatment for breast cancer, including one or more of the following: surgery, radiation therapy, chemotherapy, immunotherapy, or hormonal therapy. 5. women undergoing active chemotherapy are not allowed on study. immunotherapy or targeted agent usage is allowed. 6. women with \> 6 months of resistance training experience under expert guidance by a cscs exclusion criteria: 1. any current treatment with cytotoxic chemotherapy for breast cancer 2. inability to safely engage in group sessions of resistance training as deemed by study pl 3. severe arthritic, joint, cardiovascular, or musculoskeletal condition deemed by pl to be unsafe to engage in resistance training 4. beta blocker or glp-1 inhibitor medications 5. pregnant women 6. males

Keywords: exercise
clinical assessment of two daily wear reusable soft silicone hydrogel contact lenses

Conditions: Refractive Errors

Summary: the overall objective of this clinical study is to describe the clinical performance of the total30® soft contact lens compared to the acuvue® oasys® with hydraclear plus (aohp) soft contact lens in a daily wear modality.

subjects will be expected to attend 3 visits and wear the study contact lenses at least 5 days per week and at least 8 hours per day. on visits 2 and 3, subjects will be expected to wear the study lenses at least 6 hours prior to the study visit. the expected total duration of subject participation in the study will be approximately 1.5 months. this study will be conducted in the united kingdom (uk).

Eligibility criteria:
key inclusion criteria: * currently wearing any commercial spherical soft contact lenses with at least 3 months wearing experience. * willing to wear the study lenses for a minimum of 5 days per week and 8 hours per day. * willing to not use rewetting/lubricating drops at any time during the study. * other protocol-defined inclusion criteria may apply. exclusion criteria: * participation in a clinical trial within the previous 14 days or currently enrolled in any clinical trial. * habitual aohp contact lens wearers (in the past 3 months). * monovision wear during the study. * other protocol-defined exclusion criteria may apply.

Keywords: contact lenses myopia
study evaluating the safety and pharmacokinetics of a single dose of gsi-953

Conditions: Healthy

Summary: the purpose of the protocol is to assess the initial pharmacokinetic (pk) profile of a single oral dose of gsi-953 to healthy male japanese subjects and healthy elderly male japanese subjects.


Eligibility criteria:
* healthy males aged 20 - 40 and healthy males aged greater than 65. * body mass index range of 17.6 - 26.4 kg/m2 greater than or equal to 45 kg. * non-smokers or smoker of fewer than 10 cigarettes a day.

Keywords: japanese healthy alzheimers disease
bifeprunox in the treatment of schizophrenia

Conditions: Schizophrenia

Summary: study of the long-term efficacy and safety of bifeprunox in the treatment of schizophrenia. extension to study s154.3.001.


Eligibility criteria:
inclusion criteria: diagnosis of schizophrenia, understand nature of study, able to be managed in out-patient setting for long-term bifeprunox treatment exclusion criteria: current primary diagnosis other than schizophrenia, suicide risk, diagnosis or history of substance abuse, uncontrolled hypertension

Keywords: open-label study in the treatment of schizophrenia
hypothalamo-, pituitary-, adrenal axis dysfunction in subarachnoid hemorrhage

Conditions: Subarachnoid Hemorrhage; Cerebral Aneurysm

Summary: subarachnoid haemorrhage (sah) may cause damage to the hypotalamo-pituitary-adrenal axis (hpa) thus disturbing the hormonal response of these structures. the aim of our study is to characterize the function of hpa-axis acutely and over time up to three months in patients with sah.

the hypotalamo-pituitary-adrenal (hpa)-axis may be affected in sah by temporary or permanent damage to the hypothalamus and/or pituitary gland. also surgery or endovascular treatment of a ruptured intracranial aneurysm may affect the hormonal response of the hpa-axis. some data suggest a high incidence of delayed endocrine abnormalities in patients with sah but only little data exists on the acute endocrine abnormalities in this disease. we will study the pituitary-adrenal hormone levels in patients with acute aneurysmal sah and patients admitted for elective cranial aneurysm surgery will serve as a control population. we will use serum free cortisol calculation and total cortisol measurements as well as adrenocorticotrophic hormone (acth) stimulation test in assessing the responsiveness of the adrenal gland to exogenous acth. the hormone levels will be measured repeatedly during the first seven days after sah and once at three months.

Eligibility criteria:
inclusion criteria: sah-group: * \>age 18, * subarachnoid hemorrhage due to an cerebral aneurysm control group: * age \>18 * admitted for elective primary cerebral aneurysm surgery exclusion criteria: sah group: * any corticoid treatment (also inhaled) * usage of etomidate before study entry or during the study period * exact bleeding day unknown * previous history of sah or more than three days of current bleeding * previous aneurysm surgery or embolization * traumatic sah * known pituitary insufficiency and moribund state of the patient * refusement of the patient control group: * any corticoid treatment (also inhaled) * usage of etomidate before study entry or during the study period * previous history of sah or cerebral aneurym surgery or embolization * admitted for elective aneurysm embolization * known pituitary insufficiency * refusement of the patient

Keywords: subarachnoid hemorrhage pituitary gland adrenal gland
the effect of two distraction methods on the level of pain, fear and anxiety in children

Conditions: Pain; Anxiety; Fear; Venipuncture Site Reaction; Nursing Caries

Summary: the aim of this study is to determine the effect of watching cartoons with virtual reality glasses and tablets applied during the blood collection process on the level of pain, fear and anxiety experienced by children.

needle procedures applied to children for diagnosis and treatment cause fear, anxiety, and pain. in cases where children's pain and fear cannot be controlled, health professionals and parents may experience feelings of stress, helplessness, and guilt. many approaches reduce pain and anxiety in children during painful procedures. the most commonly used of these approaches is the distraction technique, also known as the distraction technique, which is constructed with cognitive and behavioral processes. there are many methods used to divert attention. some of those; watching cartoons, inflating balloons, creating balloons by blowing foam, directing techniques, parent coaching, using virtual reality (vr) glasses, listening to music, kaleidoscope, and using distraction cards. the research is a randomized controlled experimental study designed to determine the effects of two different methods (watching 360-degree cartoons with virtual reality glasses and watching cartoons with a tablet) during the blood collection procedure in children, on the level of pain, fear, and anxiety experienced by children.

Eligibility criteria:
inclusion criteria: * the child and family agree to participate in the research, * the child is between the ages of 5-12 * the child does not have a chronic and mental health problem. * not having a visual and hearing disability * no history of sedative, analgesic or narcotic substance use within 24 hours before admission * not having a febrile illness at the time of application * absence of a disease causing chronic pain * being treated in the green area according to the 3-level (red-yellow-green) triage system. * performing the operation at once exclusion criteria: * • the child and family's refusal to participate in the research * having a visual and auditory problem * the child is less than 5 years old or older than 12 years old * the child has a chronic and mental health problem * being treated in the red or yellow area according to the 3-level (red-yellow-green) triage system.
study to evaluate the effectiveness of the initial specimen diversion device

Conditions: Septicemia

Summary: this is a matched, open label study to evaluate the initial specimen diversion device (isdd) in reducing the contamination rate in blood culture analysis. blood culture data will be derived from inpatient and/or outpatient settings in a variety of hospital departments (e.g. er, surgical, medical, etc.). only samples that are collected via peripheral venipuncture may be included in this study. the isdd will be compared to current laboratory practices for the collection of blood for culture purposes. laboratory standard procedures (lsp) is defined as collection of venipuncture blood for culture without an initial diversion method to divert and sequester potential blood contaminants.


Eligibility criteria:
inclusion criteria: * adults \>19 years old exclusion criteria: * not a good candidate for direct-to-media (dtm) technique
safety and tolerability of ciclesonide nasal spray in patients with perennial allergic rhinitis (2-5 years old) (by9010/m1-416)

Conditions: Hay Fever; Perennial Allergic Rhinitis

Summary: the purpose of this study is to evaluate the safety and tolerability of ciclesonide nasal spray for long term use in relieving symptoms in perennial allergic rhinitis.


Eligibility criteria:
main inclusion criteria: * general good health, other than perennial allergic rhinitis * history and diagnosis of perennial allergic rhinitis by skin prick test * history of perennial allergic rhinitis for a minimum of 90 days immediately before the screening visit main exclusion criteria: * participation in any investigational drug trial within the 30 days before the screening visit * use of any disallowed concomitant medications within the prescribed withdrawal periods before the screening visit * a known hypersensitivity to any corticosteroid

Keywords: hay fever allergic rhinitis perennial allergic rhinitis ciclesonide
iht for mild cognitive impairment

Conditions: Mild Cognitive Impairment; Memory Impairment

Summary: this phase i clinical trial will examine the safety and efficacy of intermittent hypoxia training (iht) for up to 12 weeks to treat subjects with mild cognitive impairment (mci).


Eligibility criteria:
inclusion criteria: * adult men and women ages 55 to 79 years old who have been diagnosed with mci. * must be willing to be assigned to either group: treatment or sham-treatment control. * able to pay multiple visits to the lab for the proposed assessments. * able to breathe moderately hypoxic air via an air-cushioned, disposable facemask. * to have controlled stabilized chronic conditions of at least 6 months duration, such as hypertension, coronary artery disease, diabetes or metabolic disease, chronic bronchitis, degenerative osteoporosis or arthritis and/or other aging-related chronic conditions. * must be depression-free at the time of enrollment. * must have arterial oxygen saturation at or above 95% and cerebral tissue oxygenation at or above 50% at rest. * woman subject must be post-menopausal. exclusion criteria: * unwilling to sign a written consent to participate in this double-blinded placebo-controlled phase i trial. * diagnosed with ad-dementia or have impaired independent daily functioning; with mmse \<20 and/or cdr ≥1. * unable to visit the lab independently. * claustrophobic to facemask and hyper-reactive to hypoxia exposure. * expecting any major surgery or transplant. * have un-controlled chronic conditions including systolic-diastolic pressures over 150/90 mmhg with medications, diabetes, chronic renal failure (based on the medical history questionnaire), obstructive sleep apnea (based on the medical history), recurrent chest pain, seizures or epilepsies, moderate to severe carotid stenosis or calcification, brain aneurysm, uncontrolled allergic rhinitis, pulmonary fibrosis, emphysema, cancer, infectious disease, atrial fibrillation, regular pre-mature ventricular contractions, myocardial ischemia or infarct, 2nd or 3rd degree atrio-ventricular blockade. * have severe head injury or traumatic brain injury, stroke (hemorrhagic and/or ischemic). * have currently diagnosed depression. * currently have covid-19. * have any metallic implants or who are claustrophobic. * currently participating in any interventional study and/or have been previously exposed to hypoxia, such as residing more than two months at altitudes above 5000 ft. within the past 3 years or previously participated in a hypoxia training study.
incidence of pancreatic fistula after radical gastrectomy

Conditions: Gastric Cancer; Pancreatic Fistula; Complication

Summary: this study is designed to investigate the incidence of pancreatic fistula after radical gastrectomy in gastric cancer patients.

pancreatic fistula, which can lead to fatal end, is one of the most serious complications after radical gastrectomy. it is usually treated as a key factor to evaluate the quality of gastrectomy. the incidence of pancreatic fistula is far different between different areas, knowing the prevalence of pancreatic fistula and risk factors can help us to prevent pancreatic fistula and improve the short time outcome of gastric cancer surgery treatment. so, we designed this perspective, multi-center study to investigate the incidence of pancreatic fistula and its outcome in china.

Eligibility criteria:
inclusion criteria: * pathological confirmed stomach adenocarcinoma * preoperative curatively resectable tumor exclusion criteria: * pancreas resection * emergent surgery due to gastric cancer acute complications * cancer of gastric remnant

Keywords: gastric cancer pancreatic fistula gastrectomy
long-term effectiveness of the motiva implants® round and round ergonomix

Conditions: Breast Augmentation

Summary: post-marketing surveillance study to demonstrate the silent rupture rate and satisfaction of patients who underwent a primary and revision breast augmentation surgery with motiva implants®, 3 to 10 years before enrollment.

single-arm, multicenter study with a minimum of 160 subjects who underwent breast implant surgery from 3-10 years postoperatively. following irb / ec approval - and if applicable competent authority approval - magnetic resonance imaging (mri) and patient-reported outcome (pro) with the validated breast-q will be collected at a single time point for all enrolled subjects. mri data will be used for the analysis of silent rupture, and breast-q postoperative augmentation module scales to record patients for satisfaction. two styles of motiva implants® will be used for this study: * motiva implants® silicone gel-filled breast implants, smoothsilk® round (referred to as "motiva implants® round progressivegel® plus", or "round") * motiva implants® silicone gel-filled breast implants, smoothsilk® round ergonomix® (referred to as "motiva implants® ergonomix® round progressivegel® ultima®", or "round ergonomix"). henceforth, these devices will generally be referenced as "motiva implants®."

Eligibility criteria:
inclusion criteria: * cisgender women. * the subject has undergone primary or revision augmentation surgery with motiva implants® round or round ergonomix®, which are still implanted before enrolling in the study. * the subject underwent breast implant surgery at least three (3) years or more before enrolling in the study. * the subject has undergone an mri to evaluate implant rupture in the last 3 years before enrolling in the study or is willing to undergo an mri evaluation. * the subject is willing to follow all study requirements (signing informed consent, completing questionnaires, attending a baseline visit, and allowing access to previous mri images or having new mri images for the study). exclusion criteria: * the subject had undergone fat grafting, needle biopsy, or any procedures that might have caused an iatrogenic rupture. * the subject or investigator are aware of a possible ruptured device that has not been removed. * the subject is pregnant or nursing. * the subject has any condition that impedes the use of magnetic resonance imaging (mri), including implanted metal devices, claustrophobia, or other conditions that would prohibit mri scans.

Keywords: revision breast augmentation primary breast augmentation breast augmentation motiva breast implant silent rupture patient-reported outcomes