Kornimate/medical-research-clean huggingface dataset:
efficacy and safety of cilostazol in patients of vascular cognitive impairment-no dementia (vcind)

Conditions: Mild Cognitive Impairment

Summary: patients of vascular cognitive impairment-no dementia (vcind) in one group is prescribed cilostazol,in the other group is prescribed aspirin. evaluate both of them in cognitive function, mri and other sides at given time. the investigators hypothesize that cilostazol is more efficient and safer than aspirin in patients with vcind.


Eligibility criteria:
inclusion criteria: 1. aged between 50-80, both gender； 2. small vessel disease and associated cognitive impairment, diagnosed as vcind； 3. non-specific subjective symptoms (dizziness, somnolence, numbness in limbs) are acceptable. 4. normal hepatic and renal function. 5. with good compliance. exclusion criteria: 1. aged above 80 or less than 50. 2. dementia. 3. cerebral infarction(\>2cm). 4. major vascular lesion. (stenosis\>50%). 5. cardiac cerebral infarction. 6. intracerebral hemorrhage. 7. clinical manifestations cannot attribute to small vessel disease. 8. major depression or dysfunction in speech, visual ability, hearing or aphasia that would interfere with the cognitive assessment. 9. severe systematic organic impairment(cardiac, hepatic, renal dysfunction). 10. thrombocytopenic purpura. 11. history of hemorrhage in digestive system or surgery in past 3 months. 12. previously on cilostazol treatment for more than 3 month. 13. allergic to aspirin or cilostazol. 14. enrolled in other clinical trials in past 3 months. 15. lack of informed consent or compliance. 16. contraindications for mri scan.
using differences in peripheral blood leukocyte gene expression to determine cardiovascular disease risk

Conditions: Atherosclerosis; Cardiovascular Diseases

Summary: cardiovascular disease (cvd), including heart disease, heart attack, high blood pressure, and stroke, is most commonly caused by atherosclerosis, or a hardening of the arteries. traditional risk factors for cvd include age, high blood pressure, high cholesterol, diabetes, and smoking. although these established risk factors can be helpful in determining people at risk for developing cvd, the addition of novel gene markers for subclinical, or suspected, atherosclerosis (sa) may enhance cvd risk prediction and understanding of disease mechanisms. this study will compare specific genes of white blood cells in people with significant sa versus people without sa to improve identification of those at risk for developing cvd and to better understand the biological basis of sa.

cvd is the leading cause of death worldwide and accounts for almost 40% of deaths each year in the united states. in a person with cvd, oxygenated blood is not adequately distributed throughout the body because of impaired function in the heart and blood vessels. this restricted blood flow can eventually lead to organ damage, heart attack, and stroke. risk prediction for cvd, which is largely associated with sa, relies on the use of certain traditional risk factors. the widely used framingham risk score (frs) has provided excellent risk discrimination and reliable estimates of 10-year risk for cvd, but it does not account for the genetics behind sa. although numerous studies have investigated novel genetic biomarkers to attempt to add predictive value to the frs, no single biomarker to date has been able to improve risk prediction in a meaningful way. a multi-marker approach that identifies several novel markers unrelated to traditional risk factors may be more effective in improving the identification of those at risk for cvd. this study will first construct a multi-marker approach that is based on patterns of gene expression in peripheral blood leukocytes (pbls) and that can serve to identify people with substantial sa. the study will then use this approach to determine whether gene expression patterns of pbls in people with sa are distinct from those in people without sa. this study will use previously collected data and specimens, including blood samples and sa imaging, from participants in the multi-ethnic study of atherosclerosis (mesa) trial and from healthy female participants from northwestern university. blood samples will be used for analysis of patterns of gene expression in pbls. there will be no new study visits for this study. the study completion date listed in this record was obtained from the "completed date" entered in the query view report system (qvr).

Eligibility criteria:
inclusion criteria: * female participant from the mesa study who has a low framingham risk score and has either sa or no evidence of sa * healthy female below the age of 40 from northwestern university. exclusion criteria: - diabetes

Keywords: subclincal atherosclerosis
trial of zinc and hiv progression in children

Conditions: HIV Infections

Summary: to examine whether daily oral zinc supplementation to hiv-infected tanzanian preschool children reduces diarrheal and respiratory morbidity, delays hiv disease progression, and improves growth.

the purpose of this study is to examine whether daily oral zinc supplementation to hiv-infected tanzanian preschool children reduces diarrheal and respiratory morbidity, delays hiv disease progression, and improves growth.

Eligibility criteria:
inclusion criteria: * hiv infected children under 60 months of age presenting at hiv treatment clinics in dar es salaam, tanzania exclusion criteria: eligible for art: cd4 cell counts \< 20% or above pediatric clinical stage of hiv disease 3 according to who staging system. severe acute malnutrition; major congenital malformations

Keywords: zinc hiv infants children morbidity child health outcomes treatment naive treatment experienced
evaluation of health and social interventions aimed to old people discharged from hospital after a hip or wrist fracture due to a fall

Conditions: Elderly; Wrist Fracture; Hip Fracture

Summary: objectives: to describe social and health care provided to our older patients who have been admitted in the emergency department (ed) after suffering from a hip or wrist fracture due to a fall. to compare among the different hospitals and town halls, the health and social care that participants received. to compare the functional dependency and health related quality of life (hrqol) presented by the patients immediately and six months after a fall. methodology: prospective cohort study. one hundred and fifty patients suffering from each type of fracture (hip or wrist) will be recruited consecutively in the basque health system's participant hospitals sub-project. within 3 sub-projects, more than 3000 cases are expected to be collected. data will be collected from ed and hospital clinical records and by means of questionnaires to measure functional dependency (barthel and lawton indexes) and hrqol (sf-36) requesting information on status before the fall, immediately and six months later. in addition to this, data referred to care provided to the patients by traumatologist, rehabilitation or primary care provider as well as social services in their homes after the index episode will be collected.


Eligibility criteria:
inclusion criteria: * hip or wrist fracture due to an accidental fall. * providing informed consent. exclusion criteria: * physical or psychological impairments that would prevent patients from properly completing the questionnaires. * syncope. * no acceptance for taking part in the study.

Keywords: falls functionality
rirs versus eswl for the treatment of renal stones

Conditions: Renal Stones

Summary: to evaluate the effectiveness of rirs (retrograde intrarenal surgery) and eswl (extracorporeal shockwaves lithotripsy) in the treatment of renal stone ranging form 6 to 20 mm size.

european urological guidelines consider rirs and eswl the treatments of choice for renal stones \< 20 mm. rirs is a endoscopic surgery which allows to rich the kidney from the ureter. a flexible ureteroscope is used for these kind of procedure. through this device a laser fiber (holmium laser) is used to treat the stones. after that, small fragments can be removed with a basket. in some cases, according to intraoperative findings, a ureteral stent can be push in the kidney to help the drainage of the kidney. eswl is a procedure which allows to treat the stones by shock waves generated by a specific machine which work in direct contact with the skin of the patients (extracorporeal). shockwaves pass all the tissues and finally reach the stones. such energy allows to break the stones in small fragments, that wll be spontaneously passed by the patients. specific parameters of these treatments are discussed in "arms and interventions". many studies demonstrated high success rate of rirs and this technique is becoming more and more adopt. one study demonstrated better outcomes of rirs versus eswl, but only for renal stones located in the inferior calices and smaller then 10 mm. there are not other studies comparing the two procedures and there are not proofs that rirs ensures better outcomes for other renal stones (neither for size nor for location).

Eligibility criteria:
inclusion criteria: * renal stone measuring 6 to 20 mm * signing informed consent * who performance status 0-2 exclusion criteria: * other stone \>5 mm * concomitant ureteral stones * bmi \> 35 * severe coagulopathy * impossibility to sign informed consent * pregnancy * age \ 85

Keywords: ureterorenoscopy extracorporeal shock waves lithotripsy
the effect of aerobic exercise on nomophobia and anxiety

Conditions: Anxiety Disorders

Summary: it was aimed to examine the effect of aerobic exercise on nomophobia and anxiety in nomophobic university students.

it was aimed to examine the effect of aerobic exercise on nomophobia and anxiety in nomophobic university students. there is no study in the literature examining the relationship between aerobic exercise and nomophobia in young people. since our study will be the first to investigate the subject, we foresee that it is scientifically important and will shed light on future studies. in addition, national or international publications are planned after the study is completed.

Eligibility criteria:
inclusion criteria: * individuals who scored above 22 points on the beck anxiety scale and 60 points or higher on the nomophobia scale exclusion criteria: * any condition that may prevent the participant from exercising
therapeutic endoscopic ultrasound for gastrointestinal disorders: a multicenter registry study

Conditions: Therapeutic Endoscopic Ultrasound; Advanced Endoscopy; Therapeutic Endoscopy; Interventional Endoscopy; Interventional Endoscopic Ultrasound; Gastro-Intestinal Disorder; Gastrointestinal Disease; Gastrointestinal Cancer; Gastrointestinal Dysfunction; Gastrointestinal Fistula; Gastrointestinal Infection; Gastrointestinal Injury; Pancreatic Disease; Bile Duct Diseases

Summary: the purpose of this retrospective chart-review registry study is to evaluate the safety profile, efficacy profile and cost-effectiveness of the various therapeutic endoscopic ultrasound (eus) procedures (for benign and malignant gastrointestinal disorders). 1. to assess the clinical and technical success rates of eus-guided interventions 2. to document the impact of therapeutic eus procedures on the management of gastrointestinal disorders including malignancies through cost effective analyses. 3. compare endoscopic interventions to non-endoscopic interventions for the same clinical indications and evaluate safety and efficacy.

our tertiary-care institution performs clinically-indicated therapeutic endoscopic ultrasound (teus) guided interventions, including biliary and pancreatic drainage, for both malignant and benign gastrointestinal indications in more than 2000 patients annually. procedures such as biliary and/or pancreatic sphincterotomy, stents placement (metallic or plastic) and removal for revision, cysts and pseudocysts drainage are conducted in patients suffering from pancreatico-biliary disorders, gastrointestinal disorders and esophageal disorders. teus procedures are less invasive approach than surgery. moreover, they can be available to patients who are ineligible for surgery or who have refused more aggressive surgical intervention. they improve quality of life and extend survival duration. currently, there is limited multi-center data on therapeutic endoscopy clinical outcomes and standardized treatment algorithms in western populations. due to continuing variations in therapeutic eus procedures, as well as introduction of some teus procedure accessories; it is necessary to periodically evaluate the efficacy and safety of specific teus procedures and accessories for several indications to check for improved clinical outcomes. evaluation of these clinical details would help us compare them to conventional treatment modalities within our current facility and scope of practice; and consequently, help us identify safe and cost-effective treatment techniques, develop treatment algorithms and improve clinical management of patients at rwjms and other tertiary-care centers.

Eligibility criteria:
inclusion criteria: * subjects undergoing interventional therapeutic endoscopic ultrasound procedures for gastrointestinal indications exclusion criteria: * subjects not undergoing interventional therapeutic endoscopic ultrasound procedures for gastrointestinal indications
effect of esmolol on pain due to rocuronium

Conditions: Injection Site Irritation

Summary: 90 american society of anesthesiology (asa) physical status i and ii patients undergoing general anesthesia for elective surgery will be included in the study. patients will be randomized into three groups. group e will receive esmolol (1 mg/kg), group il lidocaine (0.5 mg/kg)and group c placebo(nacl 0.9%, 5 ml), followed by a 0.05 mg/kg rocuronium. after intravenous induction with propofol, adequate muscle relaxation for intubation will be received by 0.5 mg/kg rocuronium.

patients will be observed after injection of rocuronium 0.05mg/kg, then immediately asked if they have pain in the arm. the response are assessed; discomfort, pain, and withdrawal of the hand are recorded and graded using a 4-point scale (none, mild, moderate, or severe). after the intubating dose of rocuronium, withdrawal reactions are scored as follows: (a) no pain response, (b)pain limited to the wrist, (c) pain limited to the elbow/shoulder, or (d) generalized pain response.

Eligibility criteria:
inclusion criteria: * asa physical status i and ii patients * undergoing general anesthesia for elective surgery exclusion criteria: * known allergy to esmolol or lidocaine * chronic pain * pregnancy * withdrawal of consent by the patient

Keywords: esmolol, injection pain, lidocaine, rocuronium
complex exercise program for stroke patients

Conditions: Stroke; Sports Physical Therapy; Program, Communication

Summary: the physical and social effects of exercise programs and daily exercise have already been demonstrated in stroke. however, stroke survivors have shown a passive attitude towards the exercise program and there was little guideline and experience of the stroke exercise program in the community. therefore, the study provides patients with an adequate guide to a complex exercise program after discharge based on the medical records.


Eligibility criteria:
inclusion criteria: * community indwelling stroke patients discharged from pusan national university yangsan hospital * independent ambulator (fac over 4) * independent daily activities (modified rankin scale less than 2) * no apparent spasticity on hemiplegic side (modified ashworth scale less than 1) * hemiplegic side motor grades (manual muscle testing, mmt) more than 3 exclusion criteria: * mmse less than 18 * bbs less than 41 * severe aphagia who cannot communicate * severe cardiovascular conditions inhibiting exercise programs * musculoskeletal problems inhibiting exercise programs * other medical conditions considered by physiatrists
treatment of acute severe 2019-ncov pneumonia with immunoglobulin from cured patients

Conditions: 2019-nCoV; Immunoglobulin of Cured Patients

Summary: the new coronavirus pneumonia is an acute infectious pneumonia. the pathogen is a previously unknown new coronavirus, namely 2019 new coronavirus (2019 novel coronavirus, 2019 ncov). however, there is no specific anti-viral drug. it has been found that the specific antibodies against virus antigen are produced after these patients were cured, which could block the infection of 2019 ncov on the host cells. at present, immunoadsorption is the most direct, rapid and effective method to separate immunoglobulin from the cured patients. therefore, the study aims to prepare the immunoglobulin from 2019-ncov pneumonia cured patients, evaluate the efficacy and safety of the immunoglobulin in 2019-ncov pneumonia cured patients on the treatment of acute severe 2019-ncov pneumonia, and provide a new strategy for the treatment of 2019-ncov pneumonia.


Eligibility criteria:
inclusion criteria: 1. volunteers who have understood and signed the informed consent; 2. age ≥18 years, gender unlimited; 3. patients diagnosed with acute severe 2019-ncov pneumonia: 1. laboratory (rt-pcr) confirmed infection with 2019-ncov. 2. lung involvement confirmed with pulmonary ct scan. 3. at least one of the following conditions should be met: respiratory distress, rr ≥ 30 times/min; oxygen saturation ≤ 93% in resting state; pao2/fio2 ≤ 300mmhg; respiratory failure and mechanical ventilation are required; shock occurs; icu monitoring and treatment is required in combination with other organ failure. exclusion criteria: 1. viral pneumonia with other viruses besides 2019-ncov. 2. patients are not suitable for immunoglobulin therapy. 3. participation in other studies. 4. other circumstances in which the investigator determined that the patient is not suitable for the clinical trial.
safety and early efficacy of radical prostatectomy for newly diagnosed very high risk locally advanced and oligometastatic prostate cancer

Conditions: Locally Advanced and Metastatic Prostate Cancer

Summary: prostate cancer is the most common non-skin cancer diagnosed among men and the second leading cause of male cancer deaths in the united states. in 2013, it is estimated that 29,270 men have died from prostate cancer. although radiation and surgery are quite effective for localized disease, there is no effective cure for men who present with metastatic prostate cancer as the 5-year relative survival rate is only 28%. currently, androgen deprivation therapy (adt) via medical or surgical castration is the standard first-line therapy in men with metastatic disease but castration-recurrent prostate cancer (crpc) eventually emerges with a median time of 18-24 months. once crpc develops, secondary hormonal manipulation, chemotherapy, and immunotherapy are marginally effective. given the dismal prognosis of metastatic prostate cancer, new ideas and novel approaches must be explored to improve the clinical outcome. in this regard, recently emerging data suggest that local tumor control may enhance the effectiveness of subsequent systemic therapies. therefore, in this proposal, the investigators have designed a phase i/ii study in which they will prospectively evaluate the safety and feasibility of cytoreductive prostatectomy in men with newly diagnosed mpca.


Eligibility criteria:
inclusion criteria: * adenocarcinoma of the prostate * very high risk pca (psa ≥ 20 oder gleason score ≥ 8 oder ≥ ct3) and/or oligometastasierte pca (t any n positive m any, oder t any n any m positive) * ≤5 bone metastasis * ≤75 years * ability for informed consent * clinically no infiltration into the rectum or pelvic wall * clinically no visceral metastasis * male, \>18 jahre * fit for surgery * ecog performance status 0 oder 1 exclusion criteria: * male, \< 18 jahre * \> 5 bone metastasis * \> 75 years * no ability for informed consent * clinically infiltration into the rectum or pelvic wall * not fit for surgery * clinically visceral metastasis
tegsedi pregnancy surveillance program

Conditions: Hereditary Transthyretin-mediated Amyloidosis With Polyneropathy; Pregnancy

Summary: this is a worldwide safety surveillance study of pregnancy outcomes in women with hattr-pn who may have been exposed or were not exposed to tegsedi prior to or during the pregnancy and of pediatric outcomes up to 1 year of age.


Eligibility criteria:
inclusion criteria: tegsedi exposed patients (cohort 1) meeting the following criteria will be eligible for study entry: 1. pregnancies exposed to at least 1 dose of tegsedi within 25 weeks prior to conception or during pregnancy. 2. able and willing to provide informed consent. unexposed patients (cohort 2) meeting the following criteria will be eligible for study entry: 1. have a diagnosis of hattr-pn during pregnancy. 2. have not been exposed to tegsedi within 25 weeks prior to conception or during pregnancy. 3. able and willing to provide informed consent. exclusion criteria: none

Keywords: hereditary transthyretin amyloidosis with polyneuropathy hereditary transthyretin amyloidosis hattr hattr-pn rare disease
low-carbohydrate diet in children with type 1 diabetes

Conditions: Type1diabetes

Summary: the primary aim of this pilot study is to test whether low-carbohydrate diet (lcd) instituted in children/adolescents with type 1 diabetes (t1d) can improve their disease control. the primary objective of the trial is the change in continuous glucose monitoring time in target range 3.9-10.0 mmol/l (tir) in a 5-week period on lcd as opposed to a 5-week period on recommended carbohydrate diet (rcd). secondary objectives are: changes in immune parameters during the lcd period; differences in fecal microbiome during the lcd period; differences in fecal, serum and urine metabolome during the lcd period;


Eligibility criteria:
inclusion criteria: * t1d diagnosed according to the ada (american diabetes assocciation) criteria * t1d duration for at least 1 year prior to the intervention * continuous glucose monitor (cgm) worn \> 70% time in the month prior to the intervention exclusion criteria: * last hba1c \ 70 mmol/mol * subject has celiac disease * daily average carbohydrate intake \< 130 g/day from 14 days food record prior to the intervention * any concomitant disease possibly affecting glucose control * any chronic medication possibly affecting glucose control