Kornimate/medical-research-clean huggingface dataset:
effects of terlipressin on blood loss and transfusion requirements during major liver resection.

Conditions: Hepatectomy, Surgical Blood Loss, Terlipressin

Summary: to evaluate the effects of terlipressin infusion on blood loss \& transfusion requirements in cirrhotic patients undergoing major liver resections.


Eligibility criteria:
inclusion criteria: * all patients older than 18 years of age, american society of anesthesiology (asa) classification class i and ii and assigned for elective resection of 2 or more liver segments portal hypertension exclusion criteria: * patients with child-turcotte-pugh grade b or c, clinically significant portal hypertension (splenomegaly, thrombocytopenia with platelets \ 160/100mmhg), and pregnancy

Keywords: hepatectomy, surgical blood loss, terlipressin
developing and pilot testing a remote smoking cessation digital therapeutic for individuals with serious mental illness

Conditions: Smoking Cessation

Summary: this is a pilot randomized clinical trial testing an implementation intervention to support delivery of a smoking cessation app tailored to the needs of those individuals with smi who at community mental health programs.

learn to quit (ltq), an evidence-based smoking cessation app tailored to the needs of individuals with serious mental illness (smi) that demonstrated promising smoking cessation outcomes in a recent pilot randomized controlled trial (r00 da037276). in parallel, several trials demonstrated that widely available social media platforms can be effectively utilized to enhance the effects of standard of care evidence-based smoking cessation treatments. both approaches capitalize on highly scalable digital technologies, and are therefore likely to have population level impact. drawing from these two separate programs of research, the central premise of this proposal is that ltq, a stand-alone smoking cessation app tailored to patients with smi, can be enhanced with peer-support delivered on social media. therefore, this proposal seeks to develop and asses the acceptability and feasibility of ltq-connect -- the integration of the evidence-based smoking cessation app, ltq, with social support delivered via social media -- to boost the efficacy and community reach of digital therapeutics tailored for patients with smi. to achieve this goal, we will: (1) determine the ideal design requirements of an ltq-connect integration among smokers with smi, and (2) investigate the feasibility of ltq-connect in a single group pilot trial. both interventions will be combined with nicotine replacement therapy, a safe and widely available medication.

Eligibility criteria:
inclusion criteria: * must be a mental health consumer at johns hopkins bayview adult psychiatry program * a regular smoker who is willing to quit * own a smart cell phone * willing to participate exclusion criteria: * women who report being pregnant or have the intention to become pregnant in the 3 months
genetics of charcot-marie-tooth dystrophy and related diseases

Conditions: Peroneal Muscular Atrophy

Summary: this is a cross-sectional study to clarify the gene lineage distribution of cmt genes in cmt patients in my country, draw a frequency map of cmt gene distribution, and assist in determining the genetic diagnosis strategy of cmt diseases. all patients will be collected for clinical and electrophysiological data. patients and families who meet the enrollment criteria will be tested for blood tests.

\[background\] peroneal muscular atrophy (charcot-marie-tooth, cmt) is a group of the most common hereditary peripheral neuropathy, with a prevalence of about 1/2500-4000. the inheritance mode can be autosomal dominant inheritance, autosomal recessive inheritance, x-linked dominant inheritance and x-linked recessive inheritance. the typical clinical manifestations are progressive, length-dependent weakness and atrophy of the distal limbs, accompanied by hypoesthesia and weakened tendon reflexes. but the generalized peroneal muscular atrophy also includes hereditary motor neuropathy and hereditary sensory neuropathy, which represents the evolution of a disease spectrum from motor nerve to motor sensory nerve and sensory nerve, collectively referred to as cmt and its related diseases. cmt can be divided into demyelinating type (cmt1), axonal type (cmt2) and intermediate type. there are more than 80 kinds of genes discovered so far, and genetic diagnosis plays a vital role in the treatment of peroneal muscular atrophy and genetic counseling. \[purpose\] 1. to clarify the gene lineage distribution of cmt genes in cmt patients in my country, draw a frequency map of cmt gene distribution, and assist in determining the genetic diagnosis strategy of cmt diseases; 2. discover new mutations and newly published types of known genes, and perform gene-phenotype correlation analysis 3. perform whole-exome sequencing on some families that have not been clearly diagnosed to find new pathogenic genes or related genes of cmt, so as to enrich the genetic and clinical types of cmt. \[design\] this is a cross-sectional study. all patients will be collected for clinical and electrophysiological data. patients and families who meet the enrollment criteria will be tested for blood tests. the inspection strategies are as follows: (1) use mlpa method for pmp22 gene duplicate or deletion mutation check (charge); (2)) use high-throughput sequencing method to detect the currently known gene panel (gene panel) (charge); (3) check the process (1) and (2) some patients and families whose disease-causing genes have not been detected by the inspection methods are tested by whole-exome sequencing (scientific research, free of charge).

Eligibility criteria:
inclusion criteria: * meet the clinical diagnostic criteria of peroneal muscular atrophy; sign informed consent exclusion criteria: * those who have recently received blood transfusion treatment will not be able to collect blood samples.
postoperative orthostatic intolerance and hypotension in unilateral tka

Conditions: Orthostatic Intolerance; Orthostatic Hypotension; Postoperative Complications

Summary: incidence of postoperative orthostatic intolerance and postoperative orthostatic hypotension in patients undergoing unilateral total knee arthroplasty

early postoperative mobilization is a cornerstone in the so-called fast track multimodal perioperative approach and is essential in preventing postoperative morbidity and reducing hospital length-of-stay. intact orthostatic blood pressure regulation is essential for early postoperative mobilization. however, early postoperative mobilization can be delayed due to postoperative orthostatic hypotension (poh) defined as a fall in systolic pressure \> 20 mmhg and/or diastolic pressure \> 10 mmhg or due to postoperative orthostatic intolerance (poi), characterized by dizziness, nausea, vomiting, blurred vision or syncope during mobilization. previous prospective studies of major surgery have reported that oi and oh are common problem during early postoperative mobilization, with a prevalence of 42-50%. retrospective studies with a less-defined mobilization protocols have reported am oi prevalence in the range of 12-60 % across surgical procedures. the aim of our study is to determine the incidence of oi during early postoperative mobilization in fast track unilateral total knee arthroplasty.

Eligibility criteria:
inclusion criteria: * age ≥ 18 * written informed consent * patients that speak and understand danish * patients undergoing primary unilateral total knee arthroplasty in spinal anesthesia and standardized fast-track setting exclusion criteria: * alcohol or drug abuse * cognitive dysfunction * known orthostatic hypotension * use of anxiolytic drugs

Keywords: orthostatic intolerance orthostatic hypotension knee arthroplasty
two different dietary interventions for girls with polycystic ovary syndrome

Conditions: Polycystic Ovary Syndrome; Obesity; Androgen; Hypersecretion; Diet, Healthy

Summary: this study was conducted to evaluate the efficacy of the metabolic syndrome reduction in navarra (resmena) diet versus a control diet based on american heart association (aha) recommendations for the treatment of pcos in adolescents with obesity and pcos. a total of 40 adolescents diagnosed with pcos between the ages of 13-18 years were randomized to either a resmena or control diet for 6 months. dietary status, anthropometry, body composition, biochemical parameters, and reproductive endocrine hormones were compared between the 2 groups before and after the intervention.

the purpose of this study was to investigate the effect of a high meal frequency, low carbohydrate, high protein, high n-3 pufa, healthy fatty acid and antioxidant content, low glycemic load resmena diet or a control diet based on aha recommendations on anthropometric measurements, body composition, insulin resistance, lipid metabolism levels, inflammatory markers and reproductive endocrine levels in adolescents with obesity and pcos..randomized controlled study design was used in the study. patients in the study were allocated to the control and study intervention groups. participants were invited to face-to-face interviews at the beginning of the study and monthly for 6 months. anthropometric measurements, body composition analysis, and a physical activity questionnaire were performed at the beginning and end of the study, and three-day food consumption records and blood samples for the measurement of biochemical parameters were collected. in addition, the physical activity and food consumption records of the participants were repeated in monthly controls and their anthropometric measurements and body composition were analyzed and compared.

Eligibility criteria:
inclusion criteria: * diagnosis of pcos in adolescent girls according to the rotterdam criteria * age 13-18 years, * body mass index (bmi) ≥ 95th percentile exclusion criteria: * other endocrine etiological disorders (cushing's syndrome, congenital adrenal hyperplasia, mccune albright syndrome, mutations in the glucocorticoid receptor gene, ovarian and adrenal androgen-secreting tumors, hyperprolactinemia, diabetes mellitus, thyroid dysfunction, adrenal, and other endocrine disorders), * cardiovascular and cerebrovascular diseases, * hematologic disorders * liver and kidney failure * mental disorders * eating disorders * contraceptive use in the last 3 months * use of insulin-sensitizing agents * use of drugs affecting lipid metabolism (such as fish oil) * smoking.
control of emergence blood pressure during craniotomy for tumor surgery between labetolol and diltiazem

Conditions: Hypertension; Craniotomy

Summary: the purpose of this study is to determine the effectiveness of the antihypertensive drugs in the control of emergence blood pressure after tumor resection craniotomy; compared between labetalol (avexa) and diltiazem (herbessor). also the investigators seek to determine the effective dose of the antihypertensive drugs and their side effects in thai population.

the study was randomized equivalence trial

Eligibility criteria:
inclusion criteria: * patients who scheduled for craniotomy for tomor removal exclusion criteria: * allergic to labetalol or diltiazem * bradycardia \< 60 beat/min * second or third degree heart block * severe asthma or severe copd * brain stem tumor

Keywords: hypertension emergence craniotomy hypertension during the emergence after craniotomy
c-protein reactive for the detection of anastomotic leakage after surgery for digestive cancer

Conditions: C-Reactive Protein; Anastomotic Leak; Digestive System Neoplasm

Summary: the aim of this study is to investigate the diagnostic accuracy of the c protein reactive (crp) for the detection of anastomotic leakage after surgery for digestive cancer. the standard protocol in our unit is to measure the crp on the second and fourth postoperative day. the main aim of the study is to investigate the diagnostic accuracy of the ratio crp on the fourth postoperative day on crp on the second postoperative day (crp_d4/crp_d2). secondary outcomes are the diagnosis accuracy of the crp_d4 and crp_d2.

the occurrence of anastomotic fistula (af) is the most feared complication after digestive cancer surgery. it is responsible for high morbidity and accounts for more than a third of the deaths observed. the rate of anastomotic fistula reported in the literature varies between 1 and 40% according to the definition chosen by the authors. in the literature, the occurrence of the anastomotic fistula is responsible for a mortality rate of 4% and an overall morbidity of 35%. in the short term, the anastomotic fistula can put the patient's vital prognosis at risk by its septic consequences. also, it is responsible for increasing the length of stay and costs. in the longer term, anastomotic fistula affects the functional prognosis of the patient as well as oncology in patients operated for cancer. early rehabilitation becomes a standard in colorectal surgery, with exits around the 5th postoperative day. anastomotic fistulas and their complications may appear well beyond. the diagnosis is made on average around 6-7 postoperative days. at an early stage, clinical signs are inconsistent and not very specific. anastomotic fistula can manifest itself in a variety of clinical presentations, ranging from no symptoms to life-threatening septic shock. routine imaging is neither reliable nor cost-effective for the detection of anastomotic fistulas and has the disadvantage of radiation. it is necessary to find an intraperitoneal infection marker with a high negative predictive value. this is particularly important in the era of early rehabilitation, allowing for safe patient discharge with a low risk of readmission. c-reactive protein (crp) has already shown its utility in the early detection of infections after digestive surgery, however, because of conflicting results, no clear recommendations are established in the literature. our study aims are to investigate the diagnostic accuracy of the postoperative crp trajectory as an approach to eliminate the diagnosis of anastomotic fistula and to try to establish an optimal threshold with high sensitivity and negative predictive value.

Eligibility criteria:
inclusion criteria: * surgical resection for digestive cancer * creation of anastomosis. * at least one measurement of crp at the second and/or fourth postoperative day. exclusion criteria: * surgical resection without anastomosis creation * no measurement of crp on the second or the fourth postoperative day.
resynchronization in paced heart failure patients with implantable cardioverter defibrillator (icd) indication

Conditions: Heart Failure; Left Bundle-Branch Block

Summary: today patients with a cardiac resynchronization therapy (crt) indication usually receive 2 ventricular leads, right ventricular (rv) apex and left ventricular (lv) (postero-) lateral, gaining a responder rate of approximately 70%. however, the physiological agitation of the left ventricle takes place over two pathways. therefore single point stimulation might be insufficient for a dilated, insufficiently and asynchronously contracting left ventricle, resulting in either insufficient or no response to the therapy. in the "crt icd dual lv" study the patients receive a second lv lead in an anterior vein. when this lead is placed, temporary dual lv stimulation is started. to assess the effectivity of the dual lv lead stimulation intraoperatively a lv dp/dt-pressure measurement is taken. if there is an increase in lv dp/dt, the patients will be stimulated with both leads permanently. if not they will be stimulated conventionally. the patients participating in this study are monitored for 12 months after implantation.


Eligibility criteria:
inclusion criteria: * ef less than 35 percent * cad or dilatative cardiomyopathy * sinus rhythm * nyha iii or iv, stable recompensated * qrs more than 120ms * lbbb * patient signed consent form * age more than 18 and less than 80 y exclusion criteria: * permanent atrial fibrillation * permanent av-block ii or iii * tricuspidal- and or artificial aortic valve * indication for acb or acb less than 3 months ago * myocardial infarction less than 3 months * hypertrophic obstructive cardiomyopathy; constrictive pericarditis * heartfailure with iv catecholamine therapy * manifested, uncontrolled, hypo- oder hyperthyreosis * severe renal insufficiency with creatinine more than 2,5 mg per dl * patients, who did not sign the consent form * general medical conditions, which restrict the patient compliance * participation in another study * life expectancy less than 1 y * age less than 18 y or more than 80y * pregnant women or women of childbearing age

Keywords: crt dual lv triple ventricle stimulation two leftventricular leads av vv optimization lv dp/dt measurement
an endotracheal tube inserted to the level of the hypopharynx

Conditions: Intubation; Difficult or Failed; Pediatric ALL; Ventilator Lung

Summary: the goal of this observational study is to assess the incidence of successful ventilation using an ett inserted orally above the vocal cords in pediatric patients undergoing surgeries. the main question it aims to answer are: is the use of an endotracheal tube (ett), positioned in the hypopharynx with its tip placed just above the vocal cords an easy, safe and effective way for the ventilation of pediatric patients who are undergoing surgery under general anesthesia via orotracheal intubation? the procedures to be performed in this study are standard of care. they are also used by pediatric anesthesiologists in the oral intubation of pediatric patients suffering from tumor or abscess.

background: tracheal intubation can be challenging in the pediatric age group. the difficult airway algorithm is followed starting with ventilation via a facemask. in cases of difficulties in intubation and ventilation, and especially in neonates and small infants, oxygen desaturation can happen very quickly and can be life threatening. the endotracheal tube (ett), which is readily available and bypasses the tongue of the patient, can provide a safe and efficient ventilation. specific aim (s): in our study, we aim at assessing the incidence of successful ventilation using an ett inserted orally above the vocal cords in pediatric patients undergoing surgeries. secondary objectives include comparing the rate of successful ventilation between attending anesthesiologist and residents, assessing the incidence of success at first attempt, incidence of severe hypoxemia (spo2 less than 85%), and incidence of adverse events such as bradycardia, stomach insufflation, laryngospasm, and desaturation. methods: this prospective observational study will include infants and children under 6 years of age who undergo surgeries at the american university of beirut medical center (aubmc). the tube will be inserted orally above the vocal cords following which ventilation will be attempted. the exclusion criteria include pediatric patients with an existing endotracheal tube, a bmi \> 30 kg/m2, a risk of aspiration or a history of gastroesophageal reflux disease (gerd), and those undergoing emergency surgeries or whose legal guardian/representative is unwilling/unable to provide an written consent. the primary outcome is to assess successful ventilation (chest rise, end tidal co2 wave and spo2 levels). significance: this ett technique is simple to implement and use, requiring no special training or equipment. this technique can save time by ensuring patients' oxygenation and ventilation.

Eligibility criteria:
inclusion criteria: * infants and children under 6 years of age undergoing surgery * legal guardian/representative willing to sign consent exclusion criteria: * existing endotracheal tube * bmi \> 30 kg/m2 * patient with a risk of aspiration of history of gerd * inability or unwillingness of research participant's legal guardian/ representative to give consent * need for emergency surgery * asa ⅲ-ⅳ * neonates below 28 days of age
the value of post-radiation detectable plasma ebv dna in high-risk nasopharyngeal carcinoma patients

Conditions: Nasopharyngeal Carcinoma

Summary: an additional blood test at 2-3 months after rt is a valuable biomarker in predicting treatment outcome for npc patients. patients with persistently detectable ebv dna during re-staging survey 2-3 months after rt should strengthen adjuvant therapy due to very high subsequent relapse rate and poor survivals.

one week post-radiation therapy (rt) blood test showing persistently detectable ebv dna is a very poor prognostic factor for nasopharyngeal carcinoma (npc) patients. we hypothesize that additional ebv dna confirmation test could enhance diagnostic sensitivity of relapse detection and predict survivals. we screened 706 newly diagnosed npc patients who finished curative rt with or without chemotherapy from march 2001 to december 2012. additional ebv dna blood test was performed at re-staging survey 2-3 months after rt. the association between treatment outcome (tumor relapse and patients' survival) and this additional blood test along with various clinical parameters were analyzed.

Eligibility criteria:
inclusion criteria: * histologically-proven nasopharyngeal carcinoma without distant metastasis (m0) at initial presentation * npc patients who finished curative rt with or without chemotherapy exclusion criteria: * initial present m1 disease * secondary primary cancer diagnosed within 5 years * performance status (who scale) less than 2

Keywords: nasopharyngeal carcinoma radiotherapy epstein-barr virus
dopaminergic enhancement of learning and memory in healthy adults and patients with dementia/mild cognitive impairment

Conditions: Alzheimer's Disease; Mild Cognitive Impairment; Healthy

Summary: this study aims to determine whether levodopa is effective in boosting learning and memory in healthy subjects and patients with dementia or mild cognitive impairment. we also examine in healthy subjects using functional magnetic resonance imaging which brain regions mediate improved learning after levodopa administration.

prior work of our group shows that the dopamine precursor levodopa markedly improves word learning success in healthy subjects. in this randomized, placebo-controlled, double-blind trial, we probe whether administration of levodopa improves learning performance as compared to placebo administration on neuropsychological tests and in an associative learning paradigm. we postulate that levodopa improves learning success and memory performance in healthy subjects, while the effect in patients with dementia or mild cognitive impairment might depend on other factors, including severity of memory impairment.

Eligibility criteria:
inclusion criteria for patients with dementia: * patients: clinical diagnosis of ad or mild cognitive impairment * primary language german exclusion criteria for healthy subjects and patients with dementia/mci: * known allergy to levodopa or tetrazine * history of medication/drug abuse * acute nicotine withdrawal or \> 15 cigarettes per day * \> 6 cups/glasses of coffee, caffeine drinks or energy drinks per day * \> 50 grams of alcohol per day * severe hypertonia (systole \>160 mm hg) * severe arteriosclerosis * diabetes, asthma, or glaucoma * severe hearing disability * no focal brain lesions * premorbid depression or psychosis * medication with dopamine agonists or antagonists * parkinsonian symptoms

Keywords: dementia mild cognitive impairment mci levodopa learning enhancement