predictors of post-covid-19 clinical and cognitive consequences

Conditions: Post Acute Sequelae of SARS CoV 2 Infection; Obstructive Sleep Apnea

Summary: the cdc describes post-acute sequelae of sars-cov-2 infection (pasc) for the wide range of physical and mental health consequences experienced by some patients. these sequelae may be present four or more weeks after sars-cov-2 infection, including patients who had initial mild or asymptomatic acute infection. however, there is complete absence of data whether chronic sleep changes due to covid-19 infection may influence these physical and mental health consequences. while fatigue is one of the common post-covid conditions, there are no systematic examinations of sleep disturbances in covid-19 survivors. this will be a pilot observational retrospective and prospective cohort study, to systematically assess if sleep disturbances and severity of sleep apnea comprise a modifiable facet of pasc as well as the short-term and longer-term effects of covid-19 infection itself on sleep, cognitive function, exercise capacity and lung function.

this pilot study will systematically collect data to assess if sleep disturbances and severity of sleep apnea comprises a modifiable facet of pasc. this study will be the first step towards collecting preliminary data for a larger, longer-duration and more comprehensive study regarding the relationships between long-covid and sleep disturbances which can inform future healthcare strategies and clinical decision-making. the study will also explore whether inflammatory biomarkers levels during acute covid infection predict severity and duration of long-covid or pasc and sleep fragmentation post-covid. objectives: the overall goal of this project is to determine the associations between chronic post-covid fatigue and sleep duration and sleep quality in patients after recovery from sars-cov-2 infection. the investigators have adopted the cdc definition for post-covid conditions which persist for four or more weeks after sars-cov-2 infection and also is known as post-acute sequelae of sars-cov-2 infection (pasc). specific aim 1: determine associations between sleep duration and sleep quality on pasc-related fatigue symptoms, cognitive function, biomarker levels and vigilance. specific aim 2. determine if presence of obstructive sleep apnea (osa) and level of pap adherence during and prior to covid-9 infection in patients with osa predicts pasc- related fatigue, cognitive function and quality of life (qol). exploratory aim: determine whether partial or full/booster vaccinations with covid-19 mrna vaccine vs. no vaccination has an impact on chronic post-covid fatigue and sleep disturbances.

Eligibility criteria:
inclusion criteria: * all individuals 18 years or older, with prior history of covid-19 infection diagnosis * both genders including all racial and ethnic groups * patients with osa (apnea hypopnea index of 5/hour on polysomnography) with history of covid-19 infection will be eligible with prior history of covid-19 infection and without covid-19 for aim 2 exclusion criteria: * inability to give consent * active suicidal symptoms * children of all ages * pregnant women

Keywords: covid-19 quality of life neurocognitive function sleepiness sleep quality six minute walk fatigue