Kornimate/medical-research-clean huggingface dataset:
impact of a booster course of antenatal steroids on neonatal outcome in patients with premature rupture of the membranes

Conditions: Premature Birth

Summary: this trial hopes to prospectively evaluate the impact of one versus two courses of antenatal steroids on the incidence of major neonatal morbidity in pregnant women with pre-labor premature rupture of the membranes.

this is a multicenter randomized double blinded trial that hopes to prospectively evaluate the impact of one versus two courses of antenatal steroids on the incidence of major neonatal morbidity including respiratory distress syndrome in pregnant women with a singleton gestation between 24w0d - 32w6d gestation who have documented premature rupture of the membranes.

Eligibility criteria:
inclusion criteria: * participants age 18 years or older * 24w0d to 32w6d weeks gestation * singleton pregnancy * received first course of acs at or prior to 31w6d gestation * began first course of acs at least 7 days ( =/\> 168 hours) prior to randomization * expectant management planned * premature ruptured membranes (prom) before onset of labor exclusion criteria: * known major fetal anomalies * multiple gestation * not a candidate for expectant management * clinical chorioamnionitis (two or more of the following: temperature \> 38.0 degrees centigrade; uterine tenderness; foul smelling vaginal discharge or amniotic fluid; maternal tachycardia \>100 bpm; fetal tachycardia \>160 bpm; maternal white blood cell (wbc) count \>20 x 109/l; c-reactive protein (crp) \> 5.9 * already receiving corticosteroids for another condition * any contraindications to the maternal use of corticosteroids
interaction of statins and nondepolarizing muscle relaxants

Conditions: Pain

Summary: provide evidence for prevention or reduction muscle pain.

the purpose of this study is to determine interaction of statins and nondepolarizing muscle relaxant,in order to provide evidence for prevention or reduction muscle pain.

Eligibility criteria:
inclusion criteria: * patients with american society of anesthesiologists physical status i-iii * patients taking statins for at least 3 months and those who had never used statins were considered to be eligible exclusion criteria: * orthopedic * spinal surgery * surgery involving extensive muscle manipulation * history of liver and kidney failure * neuromuscular disease * susceptibility to or family history of malignant hyperthermia * extensive denervation of skeletal muscle * chronic pain syndromes * taking medications that might interact with the effect of rocuronium or serum myoglobin difficult intubation

Keywords: statins nondepolarizing muscle relaxants rocuronium myalgia
correlation between dental inclination and bone thickness in patients with class iii dentofacial deformities

Conditions: Dentofacial Deformities

Summary: the correlation between tooth inclination and bone thickness and the comparison between thickness measurements and buccolingual inclination before and after dental decompensation will be evaluated through tridimensional images in individuals with class iii dentofacial deformities.

class iii dentofacial deformity is associated with important functional, psychological and aesthetic changes and thus individuals affected by this type of deformity are motivated in seeking treatment. the sample will consist of three-dimensional images of 40 individuals with class iii dentofacial deformities. from these images generated by cbct scans, the buccolingual inclinations of all teeth and maxillo-mandibular alveolar bone thickness in three different heights will be measured (3, 6 and 8 mm) from the cementoenamel junction through the dolphin 3d® program. the 3d scans of the sample will be evaluated in two stages: the initial stage and after dental decompensation at the end of pre-surgical orthodontic phase. pearson correlation test will be used to verify the relationship between tooth inclination and bone thickness. the thickness measurements and buccolingual inclination will be compared between treatment times (initial and pre-surgical) using paired student t-test.

Eligibility criteria:
inclusion criteria: * brazilian nationality; * class iii malocclusion, for molars and canines; * concave facial profile; * indications for orthodontic-surgical treatment; * craniofacial growth finalized ; * absence of tooth extractions; * no local and / or general contraindications for surgery; * no previous orthodontic-surgical treatment; * good dental and periodontal conditions. exclusion criteria: * facial asymmetry; * absence of teeth (except the third molars); * periodontal disease and vertical or horizontal bone resorption; * extensive metal restorations; * previous orthodontic treatment; * root anomalies.

Keywords: angle class iii tomography tooth inclination bone thickness
longitudinal evaluation of taxane induced neuropathy in early stage breast cancer

Conditions: Breast Cancer

Summary: longitudinal evaluation of taxane induced neuropathy in early stage breast cancer.

a study assessing the feasibility of evaluating neuropathy symptoms prospectively using testing of gate and balance parameters.

Eligibility criteria:
inclusion criteria * patients (men and women) diagnosed with breast cancer stages i-iii initiating first line adjuvant or neoadjuvant therapy with paclitaxel or docetaxel * ability to understand and the willingness to sign a written informed consent document. * patients with functional limitations due to musculoskeletal conditions can be included, because these conditions are known to remain stable over the relatively short duration of the study. * concurrent standard and investigational agents are permissible with the standard chemotherapy drugs. exclusion criteria * prior known chemotherapy or targeted therapy (for breast cancer or other malignancies that is known to be associated with neuropathy in the last 12 months(platinum therapy, bortezomib, vinblastine, etc.) * prior taxane exposure at any time * preexisting known diagnosis of any type of neuropathy prior to start of paclitaxel or docetaxel chemotherapy * pregnant or nursing women. * unable to give informed consent. * preexisting lower extremity amputation * inability to walk or stand without assistance due to any condition * neuropathic pain medications prior to start of study including gabapentin, pregabalin, amytriptyline, and duloxetine (but initiation of neuropathic pain medications during treatment are permissible) * patients needing ambulatory assist devices * back or lower extremity surgery in the last 6 months * back or lower extremity surgery at any timepoint that interferes with gait and balance per patient or provider report

Keywords: breast cancer taxane gait men women
homocysteine in acute coronary syndrome

Conditions: Acute Coronary Syndrome

Summary: this study aims to determine the relation between high homocysteine levels and increased incidence of acute coronary syndrome in young patients

cross sectional study to: assess homocysteine level in young adult patients presenting with acute coronary syndrome

Eligibility criteria:
inclusion criteria: 1. - the patients who presented in the hospital with chest pain consistent with acute coronary syndrome with any of the following features: 1. electrocardiogram (ecg) changes: * st elevation * st depression * t wave inversion * recent left bundle branch block 2. troponin t elevation (norma value \< 0.06) 2- age: -between 18- 40 years (group a) - age \> 40 years (group b) exclusion criteria: 1. chest pain not consistent with acute coronary syndrome 2. chronic kidney disease (ckd) 3. rheumatic heart disease (rhd) 4. congenital heart disease 5. anemia 6. cancer
determinants of functional capacity in children with asthma

Conditions: Asthma in Children

Summary: the primary aim of this study is to compare the respiratory function, respiratory muscle strength, functional capacity, and lower extremity strength of children with asthma and healthy children in the same age group. the secondary aim of our study is to determine the determinants of functional capacity in children with asthma.


Eligibility criteria:
asthma group inclusion criteria: * being between the ages of 6-17 * being diagnosed with asthma * able to walk, cooperate and clinically stable * being a volunteer to participate in the study * to be able to speak, read, understand, and cooperate in turkish asthma group exclusion criteria: * history of previous lung or liver transplant * having an acute exacerbation and/or a history of hospitalization in the last 1 month * having diagnosed orthopedic problems affecting mobility or a history of musculoskeletal surgery control group inclusion criteria: * being between the ages of 6-17 * to be able to speak, read, understand, and cooperate in turkish * being a volunteer to participate in the study control group exclusion criteria: * having a diagnosed vision, hearing, or neurological disease that may affect balance * having any other neurological, orthopedic, cardiovascular, thoracic, or metabolic disease or pathological condition that would affect assessments * resting saturation below 90% during exercise tests
telenhealth and adherence to stains

Conditions: Telehealth , Lipid Lowering Medication Adherence

Summary: to evaluate the effect of telehealth through short messaging services (smss) on adherence to statins in patients with diabetes.


Eligibility criteria:
inclusion criteria: * adult (≥18 years) * both sexes * type 1 and 2 diabetes * had a prescription of lipid lowering medication with a minimum duration of two weeks * have an active contact phone number that can receive text messages * able to read sms text messages (patient, or family member) exclusion criteria: * communication impairment * taking any psychotropic medications * familial hypercholesterolemia * already established coronary heart disease * not on lipid lowering medication
safety and efficacy of brimonidine intravitreal implant in patients with geographic atrophy due to age-related macular degeneration (amd)

Conditions: Macular Degeneration

Summary: stage 1 is a patient-masked, dose-escalation, safety evaluation of brimonidine intravitreal implant. patients will receive implant in one eye and "sham" treatment (meaning no treatment) in the fellow eye. stage 2 will begin after 1 month of safety has been evaluated for stage 1. stage 2 is a randomized, double-masked, dose-response, sham-controlled evaluation of the safety and efficacy of brimonidine intravitreal implant in patients with geographic atrophy from age-related macular degeneration. patients will be followed for up to 2 years.


Eligibility criteria:
inclusion criteria: * geographic atrophy in both eyes due to age-related macular degeneration * visual acuity between 20/40 to 20/320 exclusion criteria: * known allergy to brimonidine * uncontrolled systemic disease or infection of the eye * recent eye surgery or injections in the eye * female patients who are pregnant, nursing or planning a pregnancy
brain imaging study of brain plasticity in chronic stroke patients

Conditions: Chronic Stroke

Summary: in chronic stroke patients, brain network reorganization and recovery mechanism are investigated after stroke onset using functional mri and diffusion tensor imaging analyses.


Eligibility criteria:
inclusion criteria: * more than 3 months post-stroke * ischemic or hemorrhagic stroke * a person who understands the experiment and has a willingness to participate and signs the agreement exclusion criteria: * user of artificial heartbeat * patients with claustrophobia * patients with metal implants * patients who are contraindicated for other common mri

Keywords: brain connectivity magnetic resonance imaging brain plasticity recovery
immediate implant placement with connective tissue graft or socket shield

Conditions: Tooth Fractures

Summary: the present study aims to evaluate the clinical outcomes of immediate implant placement with connective tissue graft or socket shield. previous studies have demonstrate the intact buccal bone plate plays an important role in the stability of peri-implant soft tissue around immediately placed implants. however, it remains controverisal whether soft tissue stability could be achieved in immediate implant placement with connective tissue graft or socket shield.


Eligibility criteria:
inclusion criteria: * patients in need of single implant treatment in anterior maxilla patients with small dehiscence in the buccal bone plate （\<2mm vertical bone loss and \<5mm horizontal bone loss） patients with natural teeth adjacent to implant site exclusion criteria: * uncontrolled periodontal diseases heavy smokers (\>10 cigarettes/day) unwilling to participate in the present study

Keywords: immediate implant placement connective tissue graft samll dehiscence
follow-up study with retarded release phosphatidylcholine in ulcerative colitis

Conditions: Ulcerative Colitis

Summary: follow-up study with retarded release phosphatidylcholine in ulcerative colitis objectives: the objective of the study is to evaluate the follow up of patients treated with retarded release phosphatidylcholine in three controlled, randomized studies. main question is to investigate whether treatment with phosphatidylcholine could spare patients the intake of steroids and immunosuppressants without clinical deterioration. study population: * retarded release phosphatidylcholine in chronic-active ulcerative colitis. * retarded release phosphatidylcholine in steroid dependent ulcerative colitis. * dose finding study for retarded release phosphatidylcholine outcome parameters: definition of remission: 1. sccai \<2,5 2. likert scale: grade 1 or 2 3. subjective impression of remission: yes/no 4. no blood in stool definition of relapse: 1. subjective impression: yes/no 2. sccai ≥ 5 3. blood in stool definition of low clinical activity: sccai \< 5 primary endpoint: sparing effect of steroids and/or immunosuppressants by rpc in chronic active uc. secondary endpoints 1. maintenance of continuous remission 2. improvement of disease activity: a. clinical activity (sccai) b.life quality (sibdq-d) c.likert score 3. relapse rate: a. time to first relapse b. clinical activity during relapses c. number of relapses in relation to length of treatment


Eligibility criteria:
inclusion criteria: * patients from previous studies with retarded release phosphatidylcholine exclusion criteria: * patients with less then 6 weeks follow-up after end of initial study
consequences of parenteral nutrition photoprotection on oxidant related diseases among extremely low birth weight infants

Conditions: Infant, Premature

Summary: the antioxidant system of very low birth weight infants is immature. this immaturity is implicated in the pathogenesis of diseases such as bronchopulmonary dysplasia or retinopathy. the main source of oxidant is oxygen, and parenteral nutrition is contaminated with oxidant. photoprotection decreases the oxidant load infused with parenteral nutrition. in a preliminary study, photoprotection reduced the frequency of pulmonary bronchodysplasia, increased the quantity of enteral nutrition tolerated, and decreased the arterial blood pressure among very low birth weight infants. the aim of this study is to evaluate the impact of photoprotection on oxidant related diseases among very low birth weight infants. this study is a randomized multicenter trial. in the intervention group, photoprotection is applied until the infusion of parenteral nutrition with amber bags, tubing, and syringes. the quality of photoprotection is controlled by measuring malondialdehyde and cysteine after 24 hours of infusion. the control group will receive parenteral nutrition with transparent bags and tubing. the outcomes are evaluated at 36 weeks, and 680 infants will be enrolled, with stratification among centers and gestational age.


Eligibility criteria:
inclusion criteria: * infants born before 30 weeks gestational age * postnatal age between 1 and 6 days * apgar score up to 2 exclusion criteria: * severe congenital abnormalities * intraventricular hemorrhage grade up to 2 * proven sepsis before inclusion * transfusion before inclusion * use of intravenous lipids or parenteral nutrition before randomisation

Keywords: photoprotection, parenteral nutrition oxidant stress infant, premature
prospective biceps study

Conditions: Biceps Tendon Rupture

Summary: the primary goal of this study is to determine if surgical repair of the distal biceps fully restores the supination strength of the forearm. secondarily, the investigators want to examine the insertion site location of the tendon and determine if it correlates with the patients' functional outcome as determined by disabilities of the arm, shoulder, and hand (dash), visual analog pain scale (vaps), and isometric supination torque testing.


Eligibility criteria:
inclusion criteria: * primary distal biceps repair with endobutton exclusion criteria: * any ipsilateral wrist, forearm, or elbow condition * any contraindication to having an mri

Keywords: rupture of distal bicep tendon
a study to investigate the pharmacokinetics of act-1014-6470 in subjects with severe renal impairment compared to control subjects

Conditions: Healthy

Summary: an open-label, single-dose study to investigate the pharmacokinetics of act-1014-6470 in subjects with severe renal impairment compared to control subjects


Eligibility criteria:
inclusion criteria: * signed informed consent in a language understandable to the subject prior to any study-mandated procedure. * male or female subject aged at least 18 years at screening. * women of non-childbearing potential (e.g. post-menopausal) additional inclusion criteria for subjects with severe renal impairment (group a). - severe renal function impairment as confirmed at screening based on an estimated glomerular filtration rate (egfr) using the modification of diet in renal disease (mdrd) formula of \< 30 ml/min (not on dialysis). additional inclusion criteria for control subjects (group b): * normal renal function as confirmed at screening based on egfr. * each control subject must be matched to the values of one subject with severe renal impairment based on age (±10 years difference allowed), bmi (±15% difference allowed), and sex, determined by results at screening. exclusion criteria: - any circumstances or conditions, which, in the opinion of the investigator, may affect full participation in the study or compliance with the protocol.
project amd: comprehensive characterisation of age-related macular degeneration and its progression

Conditions: Age Related Macular Degeneration; Geographic Atrophy; AMD; Age-related Macular Degeneration

Summary: age-related macular degeneration (amd) is the leading cause of irreversible vision loss worldwide, and nearly two million australians have some signs of amd. this proposed project is a prospective, observational study that seeks to to understand the underlying aetiology of amd, factors associated with differences between age-related macular degeneration (amd) phenotypes or severities, or between amd and healthy individuals. it also seeks to understand the natural history of amd progression and the factors associated with the rate of progression. in this project, the disease phenotype, genotype and severity and rate of progression will be determined based on non-invasive clinical imaging or functional assessment of the retina, from obtaining biological samples from the participants, or from patient-reported outcomes.


Eligibility criteria:
inclusion criteria: 1. 18 years of age or older; and 2. either amd (defined as having at least a medium druse \>63 um), or having eyes with normal ageing changes (including small drusen ≤63 um) or no abnormalities as control participants exclusion criteria: 1. ocular or systemic conditions other than amd that could compromise retinal assessment or assessment of amd and its progression; or 2. any participant with any mental or physical impairment that prevents them from signing an informed consent form or participating in this study.

Keywords: age related macular degeneration geographic atrophy drusen macular disease
an intervention for cardiac arrest survivors with chronic fatigue

Conditions: Heart Arrest; Cardiac Arrest; Fatigue

Summary: the primary aim was to examine the feasibility of an energy conservation + problem solving therapy (ec+pst) intervention delivered over the telephone and to evaluate the preliminary intervention effect on fatigue impact in daily activities in post-cardiac arrest (ca) adults with chronic fatigue.

the primary aim was to examine the feasibility of recruiting and retaining participants for an energy conservation + problem solving therapy (ec+pst) intervention delivered over the telephone, to evaluate the acceptability of the intervention, and to assess the appropriateness of the outcome measures. the secondary aim was to evaluate the preliminary intervention effect on fatigue impact, activity performance, and participation in daily activities in post-cardiac arrest (ca) adults with chronic fatigue.

Eligibility criteria:
inclusion criteria: * at least 3 months post-cardiac arrest * presence of moderate-to-severe fatigue: ≥ 4 score on the fatigue severity scale * availability of landline telephone or cell phone * living within 150 miles of the university of pittsburgh, oakland * functional english fluency and literacy * intact cognition * community living

Keywords: heart arrest cardiac arrest fatigue
work and health disparities among rural women

Conditions: Tendonitis; Carpal Tunnel Syndrome; Cumulative Trauma Disorders; Overuse Syndrome

Summary: this is a study of the effects of fast paced assembly line work on women. we are studying problems women in poultry processing have with their muscles, tendons, and nerves as well as acute injuries they have in the workplace. we are also studying how their work affects the quality of their lives.


Eligibility criteria:
women employed in poultry processing less than 9 months

Keywords: industrial injuries tendonitis assembly line
study of nalbuphine hcl er tablets in patients with prurigo nodularis

Conditions: Prurigo Nodularis; Nodularis Prurigo; Prurigo; Pruritus

Summary: the primary objectives of the study are to evaluate the effects of two doses of nalbuphine hcl er tablets on the change from baseline in the worst itch numerical rating scale (nrs) in patients with prurigo nodularis and to evaluate the safety and tolerability in the study population.


Eligibility criteria:
inclusion criteria: * subject suffering from generalized prurigo nodularis * have demonstrated pruritus intensity during screening * male or female who are at least 18 years old at the time of consent exclusion criteria: * subject has chronic pruritus resulting from other conditions * subject has a history of substance abuse within the past year * subject has a known drug allergy to opioids * subject is a pregnant or lactating female

Keywords: itch chronic itch nalbuphine