Kornimate/medical-research-clean huggingface dataset:
the efficacy of oral dissolution therapy (odt), extracorporeal shock wave lithotripsy (eswl), and combined eswl and odt as non-invasive modalities for treating small and medium-sized radiolucent renal stones

Conditions: Oral Dissolution Therapy; Extracorporeal Shock Wave Lithotripsy; Noninvasive; Small; Medium; Radiolucent Renal Stones

Summary: this study aimed to compare oral dissolution therapy (odt), extracorporeal shock wave lithotripsy (eswl), and a combination of eswl and odt as noninvasive modalities for treating small and medium-sized renal radiolucent.

various methods exist for managing small and medium-sized radiolucent renal stones. these range from observation to oral dissolution therapy (odt), percutaneous nephrolithotomy (pcnl), retrograde intrarenal surgery (rirs), and extracorporeal shock wave lithotripsy (eswl). oral dissolving therapy diminishes the recurrence rates of stones. it positively influences the medical management of stone activity following eswl in cases with residual calculi. by integrating oral dissolution therapy with extracorporeal shock wave lithotripsy, cases may experience the advantages of both non-invasive techniques. the combination of oral dissolution therapy and eswl is an efficient therapeutic modality for radiolucent renal stones, dramatically reducing the overall stone volume. it also reduces the frequency of necessary extracorporeal shock wave lithotripsy sessions compared to treatment with eswl alone

Eligibility criteria:
inclusion criteria: * age ≥ 18 years. * both sexes. * patients with a single radiolucent renal stone 0.5-2 cm at largest diameter diagnosed by non-contrast msct of the urinary tract (ctut) ≤ 500 hu (hounsfield unit) and not seen on kidney, ureter, and bladder (kub) x-ray. exclusion criteria: * patients with coagulation disorders, a pacemaker, severe deformity of the skeletal system, anatomical obstruction distal to the stone, and obesity (body mass index more than or equal to 35 kilograms per meter square). * patients with renal insufficiency (creatinine more than 1.7 mg/dl). * patients with active urinary tract infections.
go2 peep study: bidirectional oxygenation valve in postoperative atelectasis

Conditions: Postoperative Atelectasis

Summary: this study compares a novel breathing device, called the go2 mouthpiece, to the standard breathing tool called the incentive spirometer, thus improving respiratory dynamics of the postoperative patient.

postoperative pulmonary complications (ppcs) are the principal cause of morbidity, mortality and prolonged hospitalizations in surgical patients, which results in a 50% increase in healthcare costs compared to postoperative cardiac complications. this is especially evident following cardiovascular surgery. one of the most common ppcs is atelectasis, resulting in dyspnea, tachypnea and hypoxemia. postoperative atelectasis is a predictable consequence of anesthesia, surgical trauma, and pain associated with breathing. methods aimed at increasing lung volume and treating atelectasis, commonly known as postoperative physiotherapy, play an important role in preventing ppcs. these methods include cough and deep breathing, continuous positive airway pressure (cpap), postural drainage, incentive spirometry and positive end expiratory pressure (peep). incentive spirometry has served as a convenient approach for the postoperative patient to sustain maximal inflations and encourage deep breathing. although incentive spirometry is used commonly by post-operative patients, evidence fails to support its benefit. peep is a well-known pulmonary physiologic principle. there are on average 600 million alveoli in the lung. each alveolus has surfactant to resist the natural propensity for these small air sacs to collapse during exhalation. despite this surfactant, some alveoli will collapse and not be available for gas exchange. this atelectasis results in a ventilation/perfusion mismatch where alveolar units are perfused but not adequately ventilated. this is referred to as shunting and results in hypoxemia (decreased pao2). peep decreases the propensity for the alveoli to collapse by increasing the air pressure in the lungs. this residual pressure in the lungs at the end of exhalation decreases shunting and allows for more complete gas exchange and improved oxygenation. in patients, peep is one of the safest ways to increase pao2 and is used on almost all modern ventilator settings. the purpose of this study is to compare a novel breathing device, called the go2 mouthpiece, which uses the concept of peep, to the incentive spirometer in postoperative patients.

Eligibility criteria:
inclusion criteria 1. undergoing coronary artery bypass surgery (cabg) and/or valve replacement surgery 2. able to provide written informed consent 3. maintenance of an arterial line postoperatively exclusion criteria 1. active smoking, within three months of surgery 2. forced expiratory volume in one second (fev1) \<75% predicted 3. relative risk to develop pulmonary barotrauma as evident by history of pneumothorax or emphysema 4. unable or unwilling to provide informed consent, cognitive impairment

Keywords: cardiac surgery coronary bypass heart valve replacement postoperative pulmonary complications
the influence of anatomic deformities on the clinical efficacy in the patients with patellar dislocation

Conditions: Patellar Dislocation; Anatomic Abnormality; Trochlear Dysplasia; Femoral Anteversion; Treatment; Sport Injury

Summary: all the data of patients with patellar dislocation will be collected to evaluate the anatomic deformities. the data includes x-ray, ct, mri examinations, medical records, and physical examination information. finally, we correlate the anatomic deformities with clinical efficacy. to search for the risk factors that lead to patellar dislocation and influence the therapeutic effect.


Eligibility criteria:
inclusion criteria: -patients with patellar dislocation. exclusion criteria: * patients with significant ligamentous knee injury. * previous fracture or surgery of the lower limb. * patellar dislocation caused by car accidents or other high-energy force directly on the patella.

Keywords: patellar dislocation anatomic deformity trochlear dysplasia treatment
the observance of emergency exit treatments during the stay of care at the exit of reims emergencies

Conditions: Patient Coming to the Emergency Department for Any Reason

Summary: the investigators would like to include patients consulting in a accident and emergency department (aed) during the permanence of care the week of march 11 to 17, 2018. the data collection would concern socio-demographic data, their consultation to the aed, the follow-up given to the consultation and would take place by telephone contact of patients within 48 hours of the consultation. why patients come to the emergency room, what are they waiting for? what are their main motivations? what do they do in emergencies, do they follow the treatments and recommendations?

study of the observance of emergency exit treatments during the permanence of care. this is a descriptive study with a prospective data collection that does not alter the management of the patient. the study is epidemiological, cross-sectional, prospective inclusion. the investigators would like to include patients consulting in a aed during the permanence of care the week of march 11 to 17, 2018. the data collection would concern socio-demographic data, their consultation to the aed, the follow-up given to the consultation and would take place by telephone contact of patients within 48 hours of the consultation. the objective is to study the follow-up given by the consultation to the emergencies, in terms of compliance, follow-up of the recommendations, the objective sought by the patient coming to the emergency department. understand the motivation of the consultation and why the treatment was not followed where appropriate. is there a sociodemographic explanation or is it the health network that results in the saturation of emergency services? does the system still meet the expectations of people using it?

Eligibility criteria:
inclusion criteria: * adults * consultation during the early stages of care * leaving after consultation * agrees to participate in the study exclusion criteria: * minor patients * permanently off care * hospitalized patients * refusal to participate in the study
aortoiliac stenosis in kidney transplantation

Conditions: Aorto-Iliac Arterial Stenosis; Peripheral Arterial Disease; Kidney Transplant Failure

Summary: the impact of aortoiliac stenosis on kidney transplant patients remains unclear. this study aims to investigate the safety and efficacy of kidney transplantation in patients with aortoiliac stenosis.

kidney transplantation is the optimal treatment for end-stage renal disease (esrd). unfortunately, not all esrd patients are eligible for kidney transplantation. aortoiliac stenosis, an increasingly common type of peripheral arterial disease in esrd patients, is considered as relative contra-indication for kidney transplantation. there are several reasons for concern, such as the complexity of the vascular anastomosis and inferior life expectancy. consequently, it is still debated whether patients with aortoiliac stenosis would benefit from kidney transplantation. this study aimed to supplement current literature on the safety and efficacy of kidney transplantation in patients with aortoiliac stenosis. to achieve this, all patients undergoing kidney transplantation in erasmus medical center between january 2010 and december 2020 were enrolled, and propensity score matching was used to minimize confounding factors. additionally, long-term graft function was investigated to evaluate the impact of stenosis on graft function.

Eligibility criteria:
inclusion criteria: * patients who underwent kidney transplantation in the erasmus medical center between january 2010 and december 2020 exclusion criteria: * patients who were under 18 years at transplantation * patients who underwent combined organ transplantation * patients who had no follow-up

Keywords: aortoiliac arterial stenosis peripheral arterial disease kidney transplantation outcomes
study of the predictors of the course and early outcome of patients with systemic lupus erythematosus: nature versus nurture

Conditions: Systemic Lupus Erythematosus

Summary: objectives: i. continue yearly ascertainment visits of all patients of the established lupus in minority populations: nature vs nurture (lumina) study cohort. ii. recruit into the lumina cohort newly diagnosed patients with systemic lupus erythematosus (sle). iii. determine the impact of additional major histocompatibility complex (mhc) and non-mhc genetic factors not previously examined, specifically tumor necrosis factor, mannose binding protein, interleukin-1 receptor antagonist, and bcl-2, on the course and outcome of sle. iv. refine the assessment of those clinical and behavioral-cultural factors found to be important predictors of disease activity, damage, and functioning, thus far in these patients. v. determine the relationships among disease activity, disease damage, and physical and mental functioning in these patients as the sle progresses and the factors that predict them.

protocol outline: this is a parallel, follow up study of a natural history study. patients are stratified according to ethnicity (caucasian vs african-american vs hispanic). patients are examined at baseline and then every 6 months thereafter in order to determine the relative impact of genetic, sociodemographic, and behavioral-cultural factors on disease outcome. patients are assessed for the following outcome variables: disease activity by the systemic lupus activity measure (slam), disease damage by the systemic lupus international collaborative clinics damage index (sdi), and physical and mental functioning by the medical outcomes study 36 item short-form health survey (sf-36). patients are also assessed for independent variables belonging to the following domains: socioeconomic-demographic, clinical, immunogenetic, and behavioral-cultural. patients undergo genetic analysis utilizing polymerase chain reaction and electrophoresis to further study the immunogenetic domain and genetic markers that may be related to disease. specifically, patients' blood is analyzed for tumor necrosis factor alpha, tumor necrosis factor beta, mannose binding protein, interleukin-1 receptor antagonist, and bcl-2.

Eligibility criteria:
* all systemic lupus erythematosus (sle) patients currently constituting the established lupus in minority populations: nature vs nurture (lumina) cohort or new recruits meeting at least 4 of the 1997 american college of rheumatology criteria for the classification of sle * disease onset within the past 5 years * african-american, hispanic, or caucasian self stated, plus the same for all 4 grandparents * no concurrent participation in any intervention studies * not pregnant * not mentally retarded * no prisoners * no other concurrent disability that would preclude study

Keywords: arthritis & connective tissue diseases immunologic disorders and infectious disorders rare disease systemic lupus erythematosus
study on practical experiences of treatment with foslevodopa/foscarbidopa in advanced parkinson's disease

Conditions: Parkinson's Disease

Summary: main objective of this study is to describe the evolution of infusion settings (base, high and low infusion rates) of foslevodopa/foscarbidopa subcutaneous infusion (ldp/cdp) at different timepoints in the treatment of advanced parkinson's disease (apd) as captured in one-crm.


Eligibility criteria:
inclusion criteria: - diagnosed with levodopa-responsive idiopathic parkinson's disease prescribed on ldp/cdp csci in routine clinical practice who have consented to be enrolled in the abbvie patient support program.

Keywords: parkinson's disease
nabilone for the treatment of phantom limb pain

Conditions: Phantom Limb Pain; Neuropathic Pain

Summary: the purpose of this proposed study is to conduct a randomized double-blind placebo controlled trial assessing the benefit of nabilone in pain management and improvement of quality of life in patients with phantom limb pain. our hypothesis is that the synthetic cannabinoid nabilone will significantly reduce the phantom limb pain and improve quality of life, compared to the placebo controlled group. this will be evident by finding significant differences in visual analogue scale pain scores, frequency of phantom pain episodes, the depression, anxiety and stress scale, and the groningen sleep quality scale and daily prosthetic wearing time.


Eligibility criteria:
inclusion criteria: * the patient has been diagnosed with phantom limb pain by a rehabilitation medicine specialist. * 18-70 years old. * any gender. * the patient has not had resolution of their phantom limb pain with other treatments, such as a tricyclic antidepressant, or anticonvulsant medication. * no previous use of oral cannabinoids for pain management. exclusion criteria: * the patient's pain is better explained by a treatable cause of stump pain, such as neuroma or bony overgrowth. * gross abnormalities on routine baseline blood work including electrolytes, urea and creatinine, a complete blood count, and liver function tests (ast alt ggt, alk phos, and ldh) that are twice the limit of normal. normal tests taken within 3 months prior to the study will be accepted if there is no history of acute illness since the time the blood was drawn. * heart disease. (cannabinoids can reduce heart rate and blood pressure) patients with heart disease will be excluded based on a history of symptomatic angina, mi or chf as well as a clinical exam. * schizophrenia or other psychotic disorder * severe liver dysfunction. * history of untreated non-psychotic emotional disorders. * cognitive impairment. * major illness in another body area. * pregnancy. * nursing mothers. * history of drug dependency. * a known sensitivity to marijuana or other cannabinoid agents

Keywords: neuropathic pain phantom limb
effect of functional electrical stimulation versus theratogs on treatment of children with hemiplegic cerebral palsy.

Conditions: Cerebral Palsy

Summary: to compare the effect of functional electrical stimulation (fes) versus theratogs on gait and balance in children with hemiplegic cp.

the aim of this study was to evaluate the effect of fes versus theratogs on gait and balance in children with hemiplegic cp. thirty children with hemiplegic cp will be assigned randomly into two groups (a \& b). group a received fes by using the walkaide foot drop stimulator while group b received theratogs. patients' evaluation will be carried out before and after training to assess gait and balance performance.

Eligibility criteria:
inclusion criteria: * their weight should be less than 40 kg. * the spasticity degrees of the affected lower limb will range between grades (1, 1+ \& 2) according to modified ashworth scale (mas). * those children functioning scores at gross motor function classification system (gmfcs) levels i and ii. * they can walk 10 min conditionally without an orthosis. * ought to be intellectually skilled and ready to comprehend and take after directions. * they will have neither serious nor recurring medical complications. * children's height will be more than 100 cm to fit with the biodex balance equipment that will be used in this study to evaluate balance performance. * no serious hip \& knee flexion tightness will be present. knee flexion at starting contact should be between 20-40º . * peroneal nerve and the proximal leg muscles ought to be in place. * they ought to have no significant issues influencing balance other than spasticity. exclusion criteria: * children who demonstrate skin diseases or allergic reactions to adhesive tape or any other materials used in this study. * children with visual, auditory or perceptual deficits. * children with surgical interference for the lower limb. * children with seizures or epilepsy. * children who received botulinum toxin in the lower extremity musculature during the past 6 months or who wish to receive it within the period of study, other spasticity medication within 3 months of pre-treatment testing . * children with pacemakers or other diseases that are contraindicated by electrical stimulation.
stimulatory autoantibodies to the platelet-derived growth factor receptor (pdgfr) in patients with systemic sclerosis

Conditions: Systemic Sclerosis

Summary: this study is to determine if subjects with .systemic sclerosis have stimulatory autoantibodies to the pdgf receptor and to confirm activation (phosphorylation) of the pdgf receptor in skin sites with varying degrees of skin thickening

pilot study to assess whether patients with systemic sclerosis have stimulatory autoantibodies to the pdgf receptor and to confirm activation (phosphorylation) of the pdgf receptor in skin sites with varying degrees of skin thickening

Eligibility criteria:
inclusion criteria: 1. fulfill the american college of rheumatology criteria for systemic sclerosis or: 2. have no diseases that result in primary fibrosis of an organ system, including the skin and do not have an autoimmune disease exclusion criteria: 1. if the subject has systemic sclerosis resulting from an environmental exposure 2. if the subject has an autoimmune disease excluding scleroderma 3. if the subject has an active infection (including, but not limited to hepatitis b, hepatitis c and hiv) 4. if the subject has been treated with cyclophosphamide in the past 8 weeks. 5. if the subject is prone to bleeding because they are on medications that thin the blood or have a low platelet count.

Keywords: systemic sclerosis autoantibodies
an observational clinical study plan on the effects of radiotherapy on the immune system of patients with malignant tumors.

Conditions: Malignant Neoplasm

Summary: to explore the impact of radiotherapy on peripheral blood myeloid-derived suppressor cells (mdscs), t cells and extramedullary erythroid precursor cells in patients with malignant tumors, and to evaluate the correlation between changes in the proportion of these cells before and after radiotherapy and the efficacy of radiotherapy in patients.

to clarify the impact of radiotherapy (and/or other treatment combinations) on the proportion of myeloid-derived suppressor cells (mdscs), t cells and extramedullary erythroid precursor cells in the peripheral blood of patients with malignant tumors, and to evaluate the changes in the proportion of these cells before and after radiotherapy and the relationship between the patients correlation with the efficacy of radiotherapy. on this basis, it provides theoretical guidance for the determination of new clinical treatment plans.

Eligibility criteria:
inclusion criteria: 1. over 18 years old, diagnosed with breast cancer, nasopharyngeal cancer, colorectal cancer, cervical cancer, lung cancer, head and neck cancer and requiring radiotherapy, and the above malignant tumors have not metastasized. 2. complete inspection information. 3. no other serious complications. 4. no infectious diseases. 5. able and willing to take blood tests. 6. all researchers gave informed consent and signed an informed consent form, which complied with the requirements of the medical ethics committee. exclusion criteria: 1. people with mental illness. 2. people with autoimmune system diseases. 3. those combined with serious diseases of other organs. 4. those with severe alcoholism and drug abuse. 5. research subjects who voluntarily withdraw from the study.

Keywords: erythroid precursor cells
quality of life and nutritional status after two surgical techniques in pancreatoduodenectomy

Conditions: Delayed Gastric Emptying

Summary: this was a randomized unblinded single-centre trial. the main hypothesis of the study was that pylorus-preserving pancreatoduodenectomy reduces the incidence of delayed gastric emptying . patients undergoing pancreatoduodenectomy were randomized to undergo one of two types of surgical technique: pylorus-preserving pancreatoduodenectomy versus stardard pancreatoduodenectomy with antrectomy. the primary endpoint was the incidence and severity of delayed gastric emptying. secondary endpoints were postoperative morbidity and mortality, length of hospital stay, and nutritional status and quality of life.

this was a randomized unblinded single-centre trial without masked evaluation of the main outcome.the authors decided to compare pancreatoduodenectomy with antrectomy versus pancreatoduodenectomy with pyloric preservation. the primary aim of this randomized clinical trial was to determine whether pancreatoduodenectomy with pyloric preservation is associated with a lower incidence and severity of delayed gastric emptying. secondary endpoints were postoperative complications, postoperative mortality and duration of hospital stay. patients undergoing pancreatoduodenectomy were randomized to undergo one of two types of gastroenteric anastomosis for reconstruction. analytical parameters such as c-reactive protein, prealbumin, and albumin; as well as anthropometric measures (mean) as preoperative arm circumference mean and tricipital skinfold mean were registered preoperatively, at 5th week, and at 6th mounth. scintigraphic study had performed following a specific protocol for gastric emptying. at the end, quality of life was also analized with a quality of life questionnaire (qlpan26) preoperativelly and postoperatively.

Eligibility criteria:
inclusion criteria: * patients who underwent surgical resection of the head of the pancreas at the authors' institution from august 2003 to august 2008. adults of either sex aged over 18 years were included. exclusion criteria: * associated resections of other organs, except for the portal or superior mesenteric vein * total pancreatectomy * previous gastrectomy or other gastric surgeries * neoadjuvant treatment * liver cirrhosis.

Keywords: delayed gastric emptying pylorus-preserving pancreatoduodenectomy