Kornimate/medical-research-clean huggingface dataset:
tourniquet vs. dual-flow arthroscopy sheath in anterior cruciate ligament (acl) reconstruction

Conditions: Anterior Cruciate Ligament Reconstruction

Summary: this is a prospective randomized study comparing tourniquet use versus a dual-flow arthroscopy sheath in anterior cruciate ligament (acl) reconstruction surgery. the acl is largely responsible for knee stability and contributes to central pivot with the posterior cruciate ligament. acl rupture is associated with a violent twisting motion of the knee, which is usually irreparable without surgical intervention. acl reconstruction via arthroscopy is the gold standard treatment for young, active patients with knee instability. reconstruction is commonly performed using a thigh tourniquet to improve intraoperative visibility, reduce bleeding, and shorten procedure time. however, numerous studies associate tourniquet use with an increased risk of postoperative complications such as increased pain, muscle injury, postoperative bleeding, and deep vein thrombosis. therefore, it seems relevant to conduct further investigations into the benefits of new methods to replace tourniquet. in this context, the dual-flow arthroscopy sheath could improve postoperative recovery after acl reconstruction and could limit the risk of complications, thus improving ambulatory care for patients. this study propose to compare two groups of patients undergoing acl reconstruction: those operated on with a tourniquet versus those operated on using the dual-flow arthroscopy sheath.

initial assessments will be conducted preoperatively. the follow-up examination will take place during the first 7 days following surgery and then at 21 days (d21), 45 days (d45), and 5 months postoperatively.

Eligibility criteria:
inclusion criteria: * primary acl reconstruction * age 18 years or older * provided informed consent prior to study participation * affiliated to or beneficiary of a social security regimen exclusion criteria: * multi-ligamentous surgery * revision acl surgery * presence of a meniscal and/or chondral lesion not allowing immediate weight-bearing postoperatively * bleeding disorder * pregnant, parturient or breastfeeding women * patient under legal guardianship * any other reason which, in the opinion of the investigator, could interfere with the evaluation of the objectives of the study objectives

Keywords: anterior cruciate ligament arthroscopy dual-flow arthroscopy sheath tourniquet pain surgery
acute myocardial infarction and acute cerebral infarction (amiac) registry and follow-up

Conditions: Myocardial Infarction; Cerebral Infarction; Chronic Kidney Diseases; Mortality

Summary: a registry of consecutive patients who were admitted and diagnosed with acute myocardial infarction or acute cerebral infarction were conducted at the guangdong general hospital or the first affiliated hospital of guangzhou university of chinese medicine, yue bei people's hospital, china, between january 2000 and december 2016. the adverse clinical outcomes, including all-cause mortality, were followed from the date of admission for acute myocardial infarction or acute cerebral infarction until study end (december 31, 2016). all-cause mortality, including the date of death, was identified from the electronic hospitalization data, phone follow-up, and confirmed by the household registration (hukou) system, a record of registration required by law in china. baseline characteristics, including major treatment of acute myocardial infarction or acute cerebral infarction, estimated glomerular filtration rate (egfr) and proteinuria, were collected. demographic data were determined from the electronic hospitalization data and electronic hospital discharge records. all comorbid conditions were identified using international statistical classification of diseases, tenth revision (icd-10), coding algorithms applied to electronic physician claims and electronic hospital discharge records. life style (smoking), treatment regimen at discharge, including angiotensin-converting enzyme inhibitor (acei), angiotensin ii receptor blocker (arb), were determined from the electronic hospitalization data.


Eligibility criteria:
inclusion criteria: * consecutive patients who were admitted and diagnosed with acute myocardial infarction or acute cerebral infarction exclusion criteria: * lacunar infarction
iv nsai versus nebulized morphine analgesia for first-line renal colic

Conditions: Renal Colic

Summary: the aim of the investigators study was to evaluate the feasibility, efficacy and safety of nebulized morphine compared with non-steroidal anti-inflammatory (nsai)intravenously in the management of renal colic. determine the need for systematic outpatient prescription of nsai.

renal colic are a frequent cause of consultation in the emergency departement (ed). they count for approximatively 20% of patients presenting to the ed with severe acute onset abdominal pain. for acute treatment of renal colics (rc), guidelines recommend the use of intravenous (iv) non-steroidal anti-inflammatory (nsai) drugs in association with antalgics like paracetamol or morphine. but the nsaid present many inconvenient and cannot be used in some type of patients; that's why the investigators investigated the use of other drugs, such as nebulised morphine, in the ed treatment of renal colics. the nm has the adequacy of being quickest, more practical to use and more tolerated than the iv nsaid. in this study, the investigators aim to assess the feasibility, efficacity and safety of nebulised morphine compared to intravenous nsaid in the treatment of rc.

Eligibility criteria:
inclusion criteria: * over 16 years old * consenting to participate in the study * diagnosis of renal colic matching flank pain / lumbar fossa sided with dipstick and / or imaging confirmed the diagnosis * vas\> 50% at consultation exclusion criteria: * inability to assess pain vas; * pregnant or lactating woman; * recognized renal disease (glomerular filtration rate \<60ml/kg/1.73m2); * known hepatic insufficiency; * known or suspected allergy to nsaids, morphine * peptic ulcer known;

Keywords: renal colic nebulised morphine intravenous nsaid
effects of inspiratory muscle training in copd

Conditions: COPD; Inspiratory Muscle Weakness

Summary: the additional effect of inspiratory muscle training as an adjunct to a general exercise training program in patients with copd with inspiratory muscle weakness will be studied. the main hypothesis is that inspiratory muscle training combined with an exercise training program improves functional exercise capacity more than an exercise training program without the addition of an inspiratory muscle training program.


Eligibility criteria:
inclusion criteria: * patients with copd * eligible to participate in a exercise training intervention of 8 weeks * pi,max \<60cmh2o or \<50% of the predicted normal value exclusion criteria: * major comorbidities preventing successful participation in an 8 week exercise training intervention
effects of combined cryolipolysis and high intensity interval training on insulin resistance and body composition in polycystic ovarian patients

Conditions: Polycystic Ovary Syndrome; Hyperinsulinism

Summary: this study will be carried to investigate the effect of cryolipolysis and high intensity interval training on insulin resistance and body composition in pco women

this study will be carried out on ninety females with polycystic ovarian syndrome (pcos)l. their age ranges from 17-28 years, body mass index 25-30 kg/m2. they experience hyperandrogenism and hyperinsulinemia. pcos females will be randomly assigned into three equal groups: group (a) consists of 30 women who receive cryolipolysis and group (b) consists of 30 women who receive high intensity interval training and group (c) receive both

Eligibility criteria:
inclusion criteria: * women diagnosed with polycystic ovarian syndrome * age ranges from 17-28 years * body mass index ranges 25-30 kg/m2 exclusion criteria: * diabetic patients. * women with bmi\>30 * women having circulatory dysfunction. * women with respiratory or cardiac disease * liver disease. * skin disease . * previous abdominal or uterine surgery * any medications affecting hormones * any physical impairments * physical impairment

Keywords: pco
investigate the role of microrna in chronic rhinosinusitis from dc-th axis

Conditions: Rhinosinusitis

Summary: this study aimed to evaluate the upstream events of th17/treg imbalance in crs and their immune regulatory factors. then the investigators aimed to explore the regulatory role of mirna on dc-th axis and its dysfunction in the pathogenesis of crs, in order to determine the mirna expression profile in crs and clarify the role of mirna in the pathogenesis of crs by regulating the dc-th axis.

chronic rhinosinusitis (crs), commonly encountered in the ﬁeld of clinical otorhinolaryngology, is still a challenging proposition for doctors because of its high incidence and the unsatisfactory treatment outcomes. nowadays, studies on the pathogenesis of np are still attached great importance by researchers from each country. np has become a global health problem with a considerable socioeconomic burden. recently, research showed that the impaired balance of th17/treg was the significant basis of np. nevertheless, the pathogenesis of th17/treg imbalance was unclear. in this study, dc-th axis was designed as the main line, and the regulation of mirna on dc was designed as the entry point. this study aimed to evaluate the upstream events of th17/treg imbalance in crs and their immune regulatory factors. then the investigators aimed to explore the regulatory role of mirna on dc-th axis and its dysfunction in the pathogenesis of crs, in order to determine the mirna expression profile in crs and clarify the role of mirna in the pathogenesis of crs by regulating the dc-th axis. this study will play an important role in clarifying the pathogenesis of crs eventually and will fill the blanks of the research between mirna and crs in the investigators'country. this study is with important clinical value for establishing control strategies for crs.

Eligibility criteria:
inclusion criteria: 1. crs diagnosis is accord with diagnostic criteria of the european nasal sinusitis, nasal polyps guidelines (epos 2012) . 2. selected subjects are stopped using systemic or topical corticosteroids in one month before experiment. 3. all the patients have sinus ct and nasal endoscopy and allergen skin prick test in preoperative. 4. aged from 18 to 75 years old. 5. woman or man. exclusion criteria: 1. choanal polyp, fungal nasal sinusitis, cystic fibrosis. 2. acute upper respiratory tract infection and other diseases associated with the body.

Keywords: chronic rhinosinusitis microrna dendritic cell helper t cell
injection of local anesthetic to trocar insertion sites after laparoscopy

Conditions: Pain, Postoperative

Summary: the primary objective of this study is to assess if injection of local anesthetic to the laparoscopic trocar sites after a hysterectomy will make a difference in a patient's pain after surgery.

the growing interest in minimally invasive gynecologic surgeries have increased the number of patients undergoing laparoscopic hysterectomies. although many patients are being discharged home the same day of surgery, majority of patients complain of immediate postoperative pain after a laparoscopic hysterectomy. since postoperative pain is usually transient and improves over a short period of time, infiltration of local anesthetic to trocar insertion sites might alleviate the patient's discomfort during the recovery period. immediate post-operative pain relief further facilitates early discharge and faster patient recovery. published data regarding the effects of preemptive port site local anesthesia in gynecologic operative laparoscopy have been limited and controversial. visceral pain control through afferent nerve block could minimize pain perception especially during the first postoperative hours. this study aims to assess the influence of infiltration of local anesthetic to trocar insertion sites after laparoscopic hysterectomy on postoperative pain.

Eligibility criteria:
inclusion criteria: * patients who are scheduled for a laparoscopic hysterectomy for benign indications at the department of obstetrics \& gynecology's division of minimally invasive surgery at milton s. hershey medical center will be included. exclusion criteria: * patients who are scheduled for a hysterectomy through the vaginal or abdominal approach will be excluded. patients with preoperative indications of endometriosis or chronic pelvic pain will also be excluded since these patients could potentially have higher thresholds of pain.

Keywords: local anesthesia pain laparoscopic hysterectomy trocar site port site
incidence of various types of systemic reactions related to spinal steroid injection: a prospective study

Conditions: Incidence and Types of Systemic Reactions Occurring After Spinal Steroid Injection in a Large Population

Summary: many systemic reactions occur commonly after spinal steroid injections, especially in patients, and may be associated with underlying disease, such as hypertension and diabetes mellitus, as well as steroid dose and repetition of spinal steroid injection.

evaluate the incidence and types of systemic reactions after spinal steroid injections and to investigate the association of spinal steroid injection with patient demographics, history of previous injections, type and dose of steroid, and method and site of previous and current injections.

Eligibility criteria:
inclusion criteria: * indicaion of steroid injction. exclusion criteria: * contraindiation of steroid injction.

Keywords: spinal injection; steroid; systemic reaction; complication; side effect; diabetes mellitus; hypertension; risk factor
development of a neuronal microscope

Conditions: Hepatic Carcinoma

Summary: hepatocellular carcinoma (hcc) is the most common type of primary liver cancer and is a leading cause of cancer-related death worldwide. the prognosis of hcc remains poor, with a 5-year survival rate of 18%. risk factors for hcc include viral infection, autoimmune hepatitis, chronic alcohol use or metabolic fatty liver disease, obesity, and diabetes mellitus.

hepatocellular carcinoma (hcc) is the most common type of primary liver cancer and is a leading cause of cancer-related death worldwide. the prognosis of hcc remains poor, with a 5-year survival rate of 18%. risk factors for hcc include viral infection, autoimmune hepatitis, chronic alcohol use or metabolic fatty liver disease, obesity, and diabetes mellitus. furthermore, alterations and chronic inflammation of the microenvironment can facilitate the transformation of normal liver stem cells into precancerous tumor stem cells. all these underlying pathogenic stimuli can induce a spectrum of genetic and epigenetic modifications, which are involved in the cell cycle, cell growth and regulation of adhesion. therefore, heterogeneity and tumor priming potential arise from a combination of both endogenous and exogenous factors. however, current in vitro models, based on conventional hepatoma and hepatocarcinoma cell lines, fail to recapitulate key characteristics of tumor tissue such as three-dimensional tissue architecture, cellular heterogeneity, and cell-cell interactions. organoids, which are 3d cellular structures generated from induced pluripotent stem cells and adult tissue-resident stem cells, have recently been exploited to overcome the limitations of 2d cell culture systems, emerging as powerful tools for studying human diseases. therefore, organoid structures stably preserve the genetic information of autologous tissue by mimicking the pathological state of the tissue itself.

Eligibility criteria:
inclusion criteria: patients aged \>18 years: * undergoing surgical cholecystectomy, liver resection for hepatocellular carcinoma (both intra-tumoral and extra-tumoral tissues) or whole liver explants; * who have given consent to participate in the study. exclusion criteria: • positivity for chronic viral hepatitis (hcv-rna and hbsag).
pims-ts in intensive care: retrospective cohort trial

Conditions: Pims-Ts

Summary: pediatric multisystem inflammatory syndrome temporally associated with sars-cov-2, (pmis-ts) represents the new unit, partially imitating the previously described kawasaki disease. due to variable and frequently incomplete clinical presentation together with variable disease severity, the real incidence in pediatric population remains unclear. currently, pims-ts is defined by persistent fever, elevation of inflammatory markers, organ dysfunction (cardiac, central nervous system, respiratory, coagulation, renal, gastrointestinal), skin lesions (exanthematous), and absence of other possible etiology.

during the world covid-19 pandemic (2020-2022), pediatric patients with pims-ts represented a significant part of pediatric intensive care unit (picu) load. the initial clinical presentation of patients with pims-ts could vary significantly, and also due to progressively evolving recommendations, the diagnostic a therapy could vary regionally and over the time too. the aim of this retrospective cohort trial was to describe the initial clinical presentation, diagnostics, therapy and clinical outcome of pediatric patients admitted during 2020-2022 to the one of the 3 university hospital picus.

Eligibility criteria:
inclusion criteria: * pediatric patients with pims-ts * picu admission exclusion criteria: * insufficient data * patients not admitted to picu

Keywords: pims-ts children child intensive care critical illness
study of airway inflammation in relation to exercise in elite athletes

Conditions: Exercise Induced Asthma

Summary: high school elite training programs are today more and more under development in several 'elite sport schools' in belgium, in order to select and train future elite athletes already at young age. little is known about the effects of sustained training on the potential development of asthma in adolescents during lung growth. it would be of great importance to be able to select the individuals at risk to develop exercise-induced asthma, already at the start of their enrollment in the 'elite sport school. this would allow physicians to follow their lung function parameters very closely and regularly; and, if necessary, start treatment early after the first signs of exercise-induced asthma.

competitive swimmers, competitive indoor athletes and control individuals performing sports at a recreational level will be recruited for the study. they will perform a sport-specific training (swimmers and controls: swimming for 90 minutes, indoor athletes: basketball or volleyball for 90 minutes) baseline measurements: * airway inflammation upper and lower airways will be assessed by collection of nasal fluid (nasal sponge will be inserted in nostril for 5 minutes), fraction of exhaled nitric oxide measurement and sputum induction. * upper and lower airway symptoms will be assessed by questionnaires (sinonasal outcome measure-22, visual analogue score, asthma symptom score and juniper score) * allergy will be assessed by skin prick test (on skin) and immunocap test (in blood, 1 tube of 10 ml). * lung function and nasal patency will be measured by spirometry and peak nasal inspiratory flow measurement. * exercise induced bronchoconstriction will be assessed by eucapnic voluntary hyperventilation test. measurements immediately after training: * collection of nasal fluid * assessment of upper airway symptoms (visual analogue score) * spirometry and fraction of exhaled nitric oxide measurement * peak nasal inspiratory flow measurement measurements 24 hours after training: * collection of nasal fluid * assessment of upper airway symptoms (visual analogue score) * spirometry and fraction of exhaled nitric oxide measurement * peak nasal inspiratory flow measurement * sputum induction * venous puncture (1 tube of 10 ml)

Eligibility criteria:
inclusion criteria: * performing sports at national or international level (swimmers and indoor athletes) exclusion criteria: * performing sport at recreational level (not more than 4 hours/week for healthy individuals)
circulating tumor dna based adjuvant chemotherapy in stage ii colon cancer patients: the medocc-create trial

Conditions: Circulating Tumor DNA; Recurrence; Colon Cancer Stage II

Summary: patients in the prospective dutch colorectal cancer cohort (plcrc) with non-metastatic colon cancer that gave consent for additional blood withdrawals are enrolled in the observational plcrc-medocc substudy. in this study, blood is collected before surgery, after surgery and during follow-up. within plcrc-medocc, patients with stage ii colon cancer that are not considered to have an indication for adjuvant chemotherapy, can be included in the medocc-create subcohort under the condition that they gave informed consent in plcrc for biobanking of tissue and for future studies (trial within cohorts design). patients included in medocc-create will be randomized 1:1 to the (a) ctdna-based treatment group versus (b) the standard of care group. a total of 1320 patients will be randomized. patients randomized to the ctdna-based treatment group will have their post-surgery samples analysed directly after informed consent for medocc-create. all patients with detectable ctdna will be offered adjuvant chemotherapy (3 months capox). patients with undetectable ctdna will receive routine follow-up at the surgical department. the aim of this trial within cohorts study is to investigate how many patients with detectable ctdna after surgery start with adjuvant chemotherapy.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * informed consent for plcrc with specific consent for: * additional blood withdrawals * collection and use of tissue for scientific research * invitation for future (experimental) research within the cohort, including twics studies * inclusion in observational plcrc -medocc substudy * histological confirmed stage ii colon cancer * fit enough to receive treatment with combination chemotherapy (fluoropyrimidine and oxaliplatin) according to the treating physician exclusion criteria: * indication for adjuvant chemotherapy according to treating physician * another malignancy in previous 5 years, with the exception of treated carcinoma in situ or skin cancer other than melanoma * incomplete primary tumor resection (r1 or r2 resection) * contra-indication for fluoropyrimidines or oxaliplatin * pregnancy
muscle strength and functional autonomy of elderly women

Conditions: Muscle, Ligament and Fascia Disorders

Summary: this study shows an evaluation of the correlation between the muscle strength levels and functional autonomy of elderly women.

the aim of this study was to evaluate the correlation between the muscle strength levels and functional autonomy of elderly women with impaired muscle-skeletal system depending on the normal igf-1 level. the target-population was composed by elderly women aged between 60 and 75 years (age: 67.79 ± 5.11 years, bmi: 28.01 ± 5.4), residents of an asylum, with igf-1 levels within the normal values for the age (normo-igf-1). evaluations of the muscle strength (1-rm test) and the functional autonomy (gdlam protocol) in the performance of activities of daily living (adl), and a measurement of basal serum levels of igf-1 (chemiluminescence method) were performed.

Eligibility criteria:
inclusion criteria: * present a muscle-skeletal dysfunction, such as osteoporosis, arthritis, tendinitis, but being able to perform their adl without help from others; * did not practice physical activity for at least 12 months; * provide a normal igf-1 level for their age; exclusion criteria: * elderly women unfit to perform the strength and functional autonomy tests for the medical assessment;