Kornimate/medical-research-clean huggingface dataset:
beneficial effects of microsurgical varicocelectomy on semen parameters for causes other than infertility

Conditions: Varicocele

Summary: the purpose of this study is to evaluate whether clinical varicoceles are associated with abnormal semen parameters and whether varicocelectomy could improve the semen parameter in patients unrelated with infertility.

while most studies are continued to validate the observations of significant improvements in sperm density and motility after varicocele ligation in infertile patients, there have been few studies to investigate the effects of varicocelectomy on semen parameters in adult men unrelated with infertility. the purpose of this study was to determine whether varicocelectomy could improve the semen parameter of these patients as well as whether clinical varicoceles are associated with abnormal semen parameters in patients unrelated with infertility.

Eligibility criteria:
inclusion criteria: * men with clinical varicoceles underwent microsurgical varicocelectomy due to causes other than infertility such as testicular pain, discomfort or scrotal mass exclusion criteria: * adolescents * men with proven fertility or azoospermia * men with preoperative normal sperm analysis * available data to compare between preoperative and postoperative semen analyses
comparing diurnal fluctuations in intra ocular pressure measured in same day versus different days in glaucoma patients

Conditions: Glaucoma

Summary: glaucoma is one of the leading causes of blindness in the west. the disease caused by high intra ocular pressure (iop) and characterized by damage to the optic nerve and gradual loss of visual field. intra ocular pressure change during the day. to evaluate the efficiency of the therapy it is common to measure the intra ocular pressure at different times of the day. most ophthalmologists admit the patient for one day at which intra ocular pressure is measured at different times. this method does not mimic the patient daily routine and may not reflect the true diurnal fluctuations. for this reason some ophthalmologists measure the intra ocular pressure at different times and at different days. it is not known if both methods give similar diurnal curves.

a study physician will install anesthetic eye drops and will color the eye drops film with fluorescein. study physician will use tonometer to measure the intra ocular pressure in each eye. this is a standard procedure done in any ophthalmological examination. each patient will undergo intraocular pressure examination at 8:00, 12:00 and 16:00. in the first day intra ocular pressure will be measured at 8:00, 12:00 and 16:00, same day measurements. the day after intra ocular pressure will be measured at 8:00, two days after at 12:00 and three days after at 16:00. one month later the patient will undergo another serious of intra ocular pressure measurements. in the first day intra ocular pressure will be measured at 8:00, 12:00 and 16:00, same day measurements. the day after intra ocular pressure will be measured at 8:00, two days after at 12:00 and three days after at 16:00. the relationship between the two diurnal curves will be analyzed.

Eligibility criteria:
inclusion criteria: * glaucoma patient. * age 18-80 years * able to read and understand hebrew, able to sign informed consent in hebrew. exclusion criteria: * ophthalmic laser treatment or surgery 3 months prior to enrollment. * eye infection or inflammation. * corneal pathology altering iop measurement. * patients not cooperating during iop measurement. * non compliant patients

Keywords: glaucoma intra ocular pressure diurnal fluctuations
physical therapy interventions following arthroscopic rotator cuff repair

Conditions: Rotator Cuff Injuries; Pain, Postoperative; Kinesiophobia

Summary: in the post-arthroscopic rotator cuff repair (arcr) management, physical therapy intervention is an important factor in bringing about a clinically positive prognosis. however, no conclusive therapeutic evidence has been found for various physical therapy interventions. in this study, the investigators would like to investigate the effects of physical therapy interventions on arcr patients.


Eligibility criteria:
inclusion criteria: * adults over 18 years old * in case of 2 weeks after receiving arthroscopic rotator cuff repair * when the participants wishes to enroll in the study exclusion criteria: * 65 years old or older * if the tear area is large and augmentation is performed * if there is a previous surgical history at the surgical site * osteoarthritis in the shoulder joint
effectiveness of testofen compared to placebo on long covid symptoms

Conditions: Long Covid19

Summary: this is a double blind, randomised, placebo-controlled trial to evaluate orally-dosed testofen (a specialised extract of trigonella foenum-graecum (fenugreek) seed) compared to placebo on post covid-19 symptoms in otherwise healthy participants 18 years and over.


Eligibility criteria:
inclusion criteria: * adults 18 years and over * able to provide informed consent * diagnosed with covid-19 infection (rat or pcr test) \>4 weeks, but \< 12 months and experiencing post covid symptoms (1) * agree not to participate in another clinical trial while enrolled in this trial 1. common post covid symptoms may include fatigue, cough, chest pain, hair loss, weakness, joint pain, cardiac issues, neurocognitive impairment including memory loss, and decreased quality of life exclusion criteria: * symptoms resulting from vaccination (2) * unstable or serious illness (e.g., serious mood disorders, neurological disorders such as ms, kidney disease, liver disease, heart conditions, diabetes, thyroid gland dysfunction) (3) * current malignancy (excluding bcc) or chemotherapy and radiotherapy treatment for malignancy within the previous 2 years * receiving/prescribed coumandin (warfarin), heparin, dalteaparin, enoxaparin or other anticoagulation therapy * receiving pharmaceutical treatment for anxiety, libido, low energy * active smokers, nicotine use, alcohol, or drug (prescription or illegal substances) abuse * chronic past and/or current alcohol use (\>14 alcoholic drinks per week) * allergic to any of the ingredients in the active or placebo formula * known pregnant or lactating women * any condition which in the opinion of the investigator makes the participant unsuitable for inclusion * participants who have participated in any other related clinical study during the past 1 month * history of infection in the month prior to the study (2) symptoms must be as a direct result of having contracted covid. if symptoms only appeared within 2 weeks of a vaccination it will be considered a vaccine injury and not classed as a result of covid. (3) an unstable illness is any illness that is currently not being treated with a stable dose of medication or is fluctuating in severity. a serious illness is a condition that carries a risk of mortality, negatively impacts quality of life and daily function and/or is burdensome in symptoms and/or treatments.
a study of mabthera/rituxan (rituximab) in patients with non-bulky follicular non-hodgkin's lymphoma

Conditions: Non-Hodgkin's Lymphoma

Summary: this study will evaluate the efficacy and safety of mabthera/rituxan (rituximab) in treatment-naive patients with non-bulky follicular non-hodgkin's lymphoma. the anticipated time on study treatment is 3 months.


Eligibility criteria:
inclusion criteria: * adult patients 18-75 years of age * newly diagnosed non-bulky follicular non-hodgkin's lymphoma * \>/=1 measurable lesion * no prior treatment (no corticosteroids or radiotherapy) exclusion criteria: * transformed follicular lymphoma * cerebral or meningeal lymphomaotus localization * uncontrolled concurrent infection
mrd application in colorectal cancer patients

Conditions: Colorectal Cancer; Surgery; Chemotherapy Effect

Summary: we first collect tumor tissue and adjacent tissue to peform the wes sequencing, then collect blood after postoperative surgery 1, 3. 6, 9, 12, 18, 24 month to detect ctdna.

ctdna is obtained from plasma rather than serum, as the latter contains more dna released from immune cells during clotting. blood should be drawn into a k2edta or cell stabilization tube (e.g., streck cfdna collection tube). plasma isolation should be performed as soon as possible, no later than 24 hours, using k2edta (preferably within 4-6 hours) and, if using cell stabilization tubes, within 2-7 days, temporarily stored at 4°c. sample disposal procedure: collect whole anticoagulated blood, gently invert to fully anticoagulate, plasma fractionation should be performed as soon as possible, no later than 24 hours, temporarily stored at 4°c using k2edta (preferably within 4-6 hours), and stored at -80°c for long term. the collected anticoagulant blood is placed in an ice box containing ice packs and transported vertically to a centrifugable laboratory. centrifuge at 3000 rpm at 4°c for 15 min, take the upper layer, and aliquot 0.5 ml/tube into 1.5 ml centrifuge tubes. cryopreserved at -80 °c, 1 ml of whole blood yields approximately 0.5 ml of plasma.

Eligibility criteria:
inclusion criteria: (1) patients with colorectal tumors, whose clinical symptoms meet the diagnostic criteria of colon cancer in my country, and pathologically diagnosed as colorectal cancer after surgery; (2) patients with stage ii-iii colorectal cancer; (3) aged 30-80 years; (4) all underwent conventional radiotherapy and chemotherapy after operation; (5) complete clinical data and follow-up records were available. exclusion criteria: * (1) other serious diseases (cardiovascular and cerebrovascular diseases, kidney diseases, etc.) before operation; (2) combined with multiple primary colorectal cancers; (3) patients with other malignant tumors within the past 5 years; (4) combined with digestive tract obstruction, perforation, bleeding and other indications for emergency surgery.
prospective randomized evaluation of celecoxib integrated safety vs ibuprofen or naproxen

Conditions: Arthritis, Rheumatoid

Summary: to answer the question of overall benefit: risk of celecoxib when compared to two most commonly prescribe traditional (non-selective) nonsteroidal anti-inflammatory drugs (nsaids) in the treatment of arthritis pain. for this purpose, patients with osteoarthritis or rheumatoid arthritis with or at risk of developing cardiovascular disease will be recruited. the cardiovascular, gastrointestinal and renal safety and symptomatic benefit in each treatment group will be assessed accordingly.


Eligibility criteria:
inclusion criteria: * subjects with osteoarthritis or rheumatoid arthritis with or at risk of developing cardiovascular disease and who require and eligible for chronic, daily therapy with an nsaid to control arthritis sign and symptoms. exclusion criteria: * subjects have had a recent cardiovascular event, unstable cardiovascular conditions, or any major surgery (cardiac or non-cardiac) within 3 months prior to randomization; * subjects with medical or laboratory abnormality that would make the subject inappropriate for entry into this trial * subjects require treatment with aspirin \> 325 mg /day * subjects with known hypersensitivity to celecoxib, ibuprofen, naproxen, aspirin or esomeprazole, etc.
prevalence of hyperhomocysteinemia in thai chronic kidney disease (ckd) patients

Conditions: Cardiovascular Disease; Hyperhomocysteinemia

Summary: it is well recognized that patients with chronic kidney disease (ckd) have an increased risk for cardiovascular disease (cvd) and hyperhomocysteinemia appears to be a predictor of future cvd events. hyperhomocysteinemia has been reported to bo of high prevalence in patients with ckd. the investigators aim to study the prevalence of hyperhomocysteinemia in thai ckd patients by using thai screening and early evaluation of kidney disease (seek) study database and their relationship to cvd.

ninety eight subjects were sampling from thai seek study database traditional traditional risk factors of cvd such as total cholesterol, triglyceride, age, sex, history of smoking and blood pressure levels were examined and recorded. stored sera of these subjects were analyzed for the total homocysteine (thcy) level. analysis of variance was used to evaluate the different of mean thcy among groups

Eligibility criteria:
inclusion criteria: * ckd stages 3-4 from thai seek study exclusion criteria: * ckd stage 5

Keywords: hyperhomocysteinemia chronic kidney disease
cost of illness associated with influenza in the uk

Conditions: Influenza

Summary: the objective of this study is to describe the burden associated with influenza in the uk, from both primary and secondary care perspectives, and to stratify the burden by the annual degree of mismatch between predicted and actual virus strains.

this is a retrospective, cross sectional, exploratory, observational study using database analysis and therefore there is no patient or user group involvement.

Eligibility criteria:
inclusion criteria: * male or female patients coded within the database as having acute respiratory events that could be related to an infection between 2001 and 2009. * patients must have a minimum of 14 days observation before and after the index event to permit the capturing of complications attributable to influenza. exclusion criteria: not applicable

Keywords: illness influenza cost uk
metacognitive therapy for health anxiety

Conditions: Hypochondriasis

Summary: the study involves a comparing a new psychological treatment- metacognitive therapy (mct) which has shown promising results in the treatment of health anxiety to no treatment at all- a waiting list.

hypochondriasis or severe health anxiety is characterised by excessive, disproportionate and persistent thoughts, behaviour and emotion focused on physical symptoms and/or fear of developing a serious illness. there is often excessive worry about illness or disease in the absence of supporting medical evidence and contrary to continual medical reassurance. the most effective psychological treatments are cognitive and behavioural therapies (cbt). however, cbt has failed to demonstrate consistent gains in the treatment of this disorder. a newer form of psychological therapy, metacognitive therapy (mct) has shown to be more effective than cbt in the treatment of anxiety disorders and depression. mct is based on the principle that health anxiety is caused by a pattern of extended thinking, this pattern is called the cognitive attentional syndrome (cas). the cas is made up of chains of verbal thought in the form of excessive worry about having an illness; a pattern of focusing attention on threat, such as scanning the body for signs of illness and excessive body checking; and coping strategies that have negative effects, such as internet searching for illnesses or trying to block out thoughts of illness. rather than stopping negative thinking the cas extends it and leads to the belief that illness is present. to help reduce these symptoms mct teaches specific techniques that help people develop new ways of experiencing negative thoughts about illnesses, allow them to abandon worry and learn to disengage from unhelpful coping attempts. a recent small study has provided some limited evidence that metacognitive therapy (mct) can be applied to cases of hypochondriasis and demonstrated that the therapy was associated with improvement in symptoms. to provide future evaluation of mct in this client group a more definitive trial will be carried out to ascertain the effects of mct in a larger group when compared to a control group. if the results are positive this will provide a rationale for a larger research study, which will compare mct with evidence based treatment such as cbt.

Eligibility criteria:
inclusion criteria: * be over 18. * exceed cut off on bp and wi * not undergoing any other form of psychological therapy during treatment. * if on medication must be stable six weeks prior to treatment onset. * willing to undergo randomisation * provide written consent exclusion criteria: * be under 18 * not exceeding cut off on bp and wi * undergone cbt for health anxiety over the past three months. * having started medication less than four weeks before assessment * not willing to undergo randomisation * not willing to provide written consent
lysophosphatidylglycerol in asthma pathogenesis

Conditions: Asthma

Summary: the study aims to investigate the relationship between the small molecule metabolite lysophosphatidylglycerol and asthma clinical features and explore its involvement in asthma pathogenesis.

this study screened lpg as a asthma marker by performing metabolomics of the included asthma patients and normal controls, explored the relationship between lpg and clinical features of asthma (including acute exacerbation, asthma control state, asthma treatment steps，lung function, and inflammatory signals including eosinophils, feno and total ige), and further performed in vitro tests to investigate the specific mechanism of lpg's involvement in asthma inflammation through its influence on treg function.

Eligibility criteria:
inclusion criteria: 1. clinical diagnosis of asthma. exclusion criteria: 1. combined with chronic obstructive pulmonary disease, bronchiectasis, pneumonia, obstructive sleep apnea hypopnea syndrome, malignant tumor 2. combined with acute and chronic respiratory failure 3. combined with severe cardiovascular disease 4. pregnant woman.

Keywords: asthma lysophosphatidylglycerol treg
escape room game in oncology nursing

Conditions: Oncology; Education

Summary: this research will be conducted to evaluate the effect of the escape room game activity applied to nursing students taking oncology nursing courses on their academic self-efficacy and critical thinking motivation.

considering the characteristics of cancer patients and the complexity of care, it is essential to include a separate oncology nursing course in the education curriculum to increase the qualifications of nursing students. during undergraduate nursing education, clinical practices for care in oncological diseases are limited. new approaches are needed that will contribute to increasing the effectiveness of the educational processes of nursing students. escape room game-based educational approaches, which have begun to be used in nursing education in recent years, are presented as an example of this situation. escape games are defined as a type of student-centered activity designed to improve students' learning and skills in professional development programs. the main purpose of using escape games in nursing education is to create practice environments where students will gain clinical decision-making competence in order to provide safe and qualified patient care services. this research was designed to determine the effect of the escape room game applied to students taking oncology nursing courses on their academic self-efficacy and critical thinking motivation.

Eligibility criteria:
inclusion criteria: * being enrolled in the oncology nursing course and volunteering to participate in the study exclusion criteria: * not completing the game during the escape room game and/or filling in the scales and forms incompletely

Keywords: game self efficacy thinking student oncology nursing education
the novel electrolyzed water spray treatment mild periodontitis

Conditions: Periodontitis

Summary: the purpose of this study is to test whether spraying the tooth of patients by use of the novel electrolyzed water spray will produce improvement in the condition of mild periodontitis.

in this study, water inculding tap water,pure water and salt water, and an apparatus for producing electrolyzed water (https://www.deposon.com.cn; https://www.deposon.com）were used to generate an electrolyzed water mist spray or spray. this instantly generated electrolyzed water mist spray or spray has oxidation-reduction potential (orp) ≥1200mv,and contains non-specific total oxidation capacity which equals to 0.28±0.10ppm,0.06±0.04ppm and 3.92±0.39ppm of desolved ozone. this instantly generated electrolyzed water mist spray or spray does not release detectable ≥0.1mg/m3 of gaseous ozone. this instantly generated electrolyzed water mist spray or spray has ph 8.4±0.4 and releases negative air ion.the apparatus for producing electrolyzed water has a positive electrode which is covered by a conductive diamond material (patent# cn215308550u). this is an open-label, single-arm, and before and after treatment comparison study. this study uses this novel electrolyzed water device and the water spray to treat mild periodontitis.

Eligibility criteria:
inclusion criteria: * mild periodontitis accompanied by gingival discomfort. * patient \> 18 years old. * systemically healthy individuals exclusion criteria: * severe periodontitis. * 80 years or older. * patients who take anticoagulants or antiplatelet agents * pregnant or breastfeeding women

Keywords: electrolyzed water device hydroxyl radical tap water spray periodontitis gingival redness gingival swelling gingival bleeding
the therapeutic use of botulinum toxin type a in subacute cervical/upper back pain

Conditions: Subacute Cervical Pain; Subacute Upper Back Pain

Summary: to determine the therapeutic efficacy of botox not only for chronic cervical/upper back pain but also for subacute pain.

subjects diagnosed with subacute (2-6 months post-onset) bilateral cervical/ upper back pain will be recruited in this double-blind control study. a total of 30 subjects with subacute cervical/upper back pain will be recruited. if patients are qualified as participants and agreed to participate in the study by signing the consent form, they will be randomized into either (a) control group (injection of normal saline injection) or (b) study group (injection of botox). the initial history taking step will include medical history including medication and surgery history, duration of pain, pre-injection neck disability index (ndi) and visual analogue scale (vas) for pain. vas score will be collected for 4 weeks before injection to ensure stable vas, otherwise medical records will be reviewed to ensure stable feature of pain. short form (sf) -36 health survey will be used to assess functional status, and the beck depression inventory (bdi) will be applied to assess psychological aspect. physical examination will be performed to determine the most tender cervical/ upper back muscles, and rule out operative condition. a simple swallowing test (3-oz water swallowing test) will be applied for dysphagia screening. the patients will be maintained with routine, standardized physical therapy, oral medication, and stretch exercise after the injection. ndi, vas, and sf-36 questionnaire will be re-collected at 1, 2, 3, 4, and 6 months after the injection session.

Eligibility criteria:
inclusion criteria: * male or female 18 y/o or greater, * subacute bilateral cervical/ upper back pain, pain of longer than 2 months and shorter than 6 months duration, * vas pain score of 5 or greater for the cervical/ upper back pain for 4 week period before injection, * if female or child bearing potential, concurrent use of a reliable method of contraception. exclusion criteria: * known allergy or sensitivity to botulinum toxin type a. * any medical condition that may put the subject at increased risk with exposure to botox®, including diagnosed myasthenia gravis, eaton-lambert syndrome, amyotrophic lateral sclerosis, or any other significant disease that might interfere with neuromuscular function * use of aminoglycoside antibiotics, curare-like agents, or other agents that might interfere with neuromuscular function * pregnancy, breast feeding, or planned pregnancy * acute or operative pathology on cervical mri * history of treatment for gatro-esophageal reflux disease * abnormal finding on 3-oz water swallowing test on the initial screening visit