Kornimate/medical-research-clean huggingface dataset:
improving clinician capacity to provide interventions for manual wheelchair users

Conditions: Paraplegia; Paralysis, Legs

Summary: the objective of this study is to determine the effectiveness of remote manual wheelchair skills training program for clinicians. the study will use three-group approach: intervention with remote feedback (group 1), control group (group 2), and structured self-study (group 3). this demonstrates how the intervention compares not only to a control, but also to the next "best alternative" - therapists sourcing web-based training materials and learning independently.

a randomized, single-blinded, two-period cross-over study design for groups 1 and 2 will be used. participants will complete baseline assessments and then be randomized to either group 1 or group 2. after enrollment for groups 1 and 2 is completed, group 3 participants will be enrolled. group 1 will receive the active intervention (intervention a) which will include a two-part training in wheelchair skills. for part 1, they will review approximately 4 hours of educational videos on how to complete and teach wheelchair skills. for part 2 they will complete a practice-feedback loop with a remote trainer providing asynchronous feedback. group 3 will mirror group 1 but complete only part 1 of the training. group 2 will receive the control intervention (intervention b) participants will review approximately 4 hours of educational videos. participants will have 8 weeks to complete either training program. both groups will then complete follow-up at 2 and 6 months. following this, participants will cross over to receive the other intervention (group 1 and 3 will receive intervention b, group 2 will receive intervention a) and complete follow-up at 8 and 12 months. additionally, rehabilitation professionals who are not therapists will be able to access the training through a structured self-study (group 4). this group will receive access to both trainings with follow-up at 2 and 6 months.

Eligibility criteria:
inclusion criteria: 1. practicing rehabilitation professional whose client population includes wheelchair users. 2. willing and able to attempt practicing wheelchair skills 3. access to a spotter(s) 4. access to an internet-ready device with video capabilities. 5. speaks english exclusion criteria: 1) confident in teaching (self-efficacy on assessing, training, and spotting \[seats\] item score = 5) and able to complete (wst-q capacity item score = 2) \>50% of skills targeted by the training intervention.
dietary intake modifications to protect against changes in bone metabolism

Conditions: Bone Resorption

Summary: bone loss is not only a well-documented effect of spaceflight on astronauts, but also a condition that affects millions of men and women on earth each year. many countermeasures to bone loss have been proposed, and many have been evaluated to some degree. to date, those showing potential have focused on either exercise or pharmacological interventions, but none have targeted dietary intake alone as a factor to predict or minimize bone loss during spaceflight. the investigators proposed to document how the ratio of acid precursors to base precursors in the diet is related to directional changes in markers of bone resorption and formation during flight and recovery from flight. there is a high likelihood for success in predicting the extent of bone loss from dietary intake patterns of astronauts during spaceflight, given that this concept is strongly anchored in data obtained from ground-based experiments in our laboratory and others. the notion of manipulating diet to minimize bone loss could also have significant social and economic impacts for nasa and for the general public - especially given the increasing trends for diets that are high in animal protein and low in fruits and vegetables. the results of the proposed experiments will lead to development of a dietary countermeasure for bone loss consisting of a balanced diet with no associated risks for side effects that might be present with pharmaceuticals or supplements, no requirement for payload mass, and no additional crew time necessary during flight.


Eligibility criteria:
inclusion criteria: * astronauts flying on long-duration (3-6 months) spaceflights exclusion criteria: * non-astronauts

Keywords: bone resorption diet
clinic trial in phase 1 using amniotic membrane for the skin replacement in big wounds

Conditions: Wound

Summary: the purpose of this study is to determine the safety of use of a new therapeutic strategy for the treatment of patients with large wounds

amniotic membrane (am) is a useful tissue as a biological dressing with numerous advantages it has a very similar structure to the skin and his biological and immunological properties.

Eligibility criteria:
inclusion criteria: * acute wounds in granulation phase with a minimum surface of 100cm2 * ≥ 18 years * signing informed consent form * guarantee adherence to protocol exclusion criteria: * chronic arterial insufficiency * pregnant patients, lactating women or fertile adults that they don't use an effective contraceptive method * involved in other assay * previous disease; kidney, heart, hepatic, systemic or immune * inability to understand informed consent form

Keywords: skin injury membrane amniotic wound
establishment of a registry of patients with parathyroid disease

Conditions: Hyperparathyroidism; Hypoparathyroidism

Summary: establishment of a registry with which to census all patients under the care of the o.u. endocrinology for parathyroid pathology in order to longitudinally evaluate biochemical, clinical, radiological, medico-nuclear and histological data in future studies.

inclusion in the registry will be offered consecutively to any patient with parathyroid pathology (hyperparathyroidism or hypoparathyroidism) diagnosed and evaluated at the endocrinology operating unit through at least two endocrinology visits. the registry will include patients seen from 1/1/2000 for a duration of 30 years. follow-up duration for each patient is expected to be 10 years, with enrollment until 12/31/2029, and registry update deadline on 12/31/2039.

Eligibility criteria:
inclusion criteria: * age ≥18 years * diagnosis of hyperparathyroidism or hypoparathyroidism based on biochemical parameters (calcemia, parathormone, phosphormia, creatinine, albumin, vitamin d25oh) * obtaining informed consent exclusion criteria: * none
pharmacological intervention in diabetic retinopathy

Conditions: Diabetic Retinopathy

Summary: the purpose of this study is to determine if diabetic retinopathy can be treated with prostaglandin analogues, prostaglandin synthesis inhibitors or carbonic anhydrases inhibitors.

disturbances in retinal perfusion is believed to be involved in the pathophysiology of diabetic retinopathy. these disturbances may be due to changes in the basal diameter of retinal arterioles and to disturbances in the autoregulation of the diameter of these vessels when the blood pressure and the retinal metabolism changes. in vitro studies have shown that prostaglandins and carbonic anhydrases inhibitors are involved in the tone regulation of retinal arterioles, but it is unknown whether this finding is relevant in clinical practice. this can be tested in vivo by an retinal vessel analyzer measuring the dynamics of the retinal vessel diameter changes.

Eligibility criteria:
inclusion criteria: * diabetes type 1 with moderate diabetic retinopathy/healthy * blood pressure \< 135/85 mmhg exclusion criteria: * eye disease (excluding diabetic retinopathy) * allergic * kidney disease * liver disease * severe asthma * heart disease * hypertension arterial * users of drugs that influence the metabolism of the prostaglandins in the carbon dioxide * pregnant and breastfeeding women and women who don't use secure contraception * persons who can't do without contact lens in the treated eye.
relationship of trunk control and endurance with balance and functional mobility in cerebral palsy

Conditions: Cerebral Palsy

Summary: it is predicted by studies that the motor and cognitive performance disorders seen in children with cerebral palsy (cp) may lead to loss of balance, postural control and mobility. at the same time, trunk muscle fatigue seen in children with cp is a critical motor problem and may cause deficits in adjusting the proper connection between the trunk and pelvis stabilizers.these deficits can lead to impairments in balance, postural control and mobility. considering the relationship between the deficits seen in children with cp and postural control and postural control with the trunk, the idea that there is a need for studies that evaluate the trunk in every way and reveal its relationship with balance, postural control and mobility in order to organize the rehabilitation program effectively in children with cp. therefore, in the planning of our study, it was aimed to evaluate trunk control and endurance in children with cp and to examine their relationship with balance and functional mobility parameters, as well as to reveal their relationship with functional health and quality of life.


Eligibility criteria:
inclusion criteria: being diagnosed with cerebral palsy volunteer be between the ages of 6-18 being at level 1 and 2 according to gross motor function classification system (gmfcs) (level 1-2). to have the cognitive skills to understand and apply the evaluation parameters. exclusion criteria: participants diagnosed with cerebral palsy having cognitive disorders participants diagnosed with cerebral palsy having vision or hearing problems participants diagnosed with cerebral palsy have a history of trauma such as botox or muscle relaxation operation and / or fracture at least 6 months before participating in the study.

Keywords: cerebral palsy trunk control mobility balance functional health endurance
investigation of the effects of holistic group exercise program on muscle thickness and physical performance in older adults with sarcopenia

Conditions: Sarcopenia

Summary: a decrease in muscle mass and function can cause the development of many chronic diseases, including sarcopenia. it has been reported that the best intervention for sarcopenia is exercise. despite this, the optimal type of exercise for sarcopenia has not yet been determined. although the holistic approach is used in the literature in the elderly population, it is noticeable that it does not find much space for itself in this patient group. in this study, it was aimed to examine the effects of holistic approach-based exercise program on individuals with sarcopenia.


Eligibility criteria:
inclusion criteria: * being over the age of 65 * getting a diagnosis of sarcopenia * to be able to walk at least 10 meters independently in public * getting a score of 4 and above from the clock drawing test * volunteer individuals exclusion criteria: * having a neurological disease * having an uncontrollable cardiopulmonary disease * acute illness that will prevent him/her from understanding and performing the exercises to be performed status or the presence of significant cognitive impairment * providing continuity for less than 80% of the exercise program
a pilot study on the effect of cannabis oil in untreatable liver cancer patients

Conditions: Hepatocellular Carcinoma; Cannabis

Summary: to study the anti-tumor effect of cannabis oil (thc10% / cbd5%) in untreatable hcc patients based on mrecist and recist criteria


Eligibility criteria:
inclusion criteria: * age =\>18 yrs * histologically proven hepatocellular carcinoma * non-cirrhosis or child pugh a cirrhosis * hepatic encephalopathy grade 0 or 1 * multidisciplinary treatment (mdt)-advised best supportive care for untreatable advanced hcc or patients unable to undergo or declining treatment for advanced hcc. * minimal life expectancy of 3 months * willing and able to attend follow-up examinations * willing to stop active traffic participation or controlling machinery during the study period if applicable * signed informed consent * language: dutch or english exclusion criteria: * child pugh b or c cirrhosis * hepatic encephalopathy grade 2 or more * previous systemic treatment for hcc * mental conditions rendering the subject incapable to understand the nature, scope and consequences of the trial * use of medicinal cannabis for other purposes * contra-indications for medicinal cannabis oil: * patients who have experienced a myocardial infarction or clinically significant cardiac dysfunction within the last 12 months or have had a cardiac disorder that, in the opinion of the investigator would have put the participant at risk of a clinically significant arrhythmia or myocardial infarction. * patients with known psychotic disorders * female patients who are pregnant or lactating * patients (men or women) intending to start a family * hypersensitivity to cannabinoids or any of the excipients of the cannabis oil
evaluation of the compatibility of different eye lid retractors to the direct selective laser trabeculoplasty (dslt) procedure

Conditions: OAG - Open-Angle Glaucoma

Summary: direct selective laser trabeculoplasty (dslt) is an emerging therapeutic technology to treat glaucoma. dslt was previously tested in 2 clinical trials and demonstrated promising safety and efficacy results in reducing the patient's intra ocular pressure. experience gained in the previous clinical studies indicates that a full exposure of the limbal area may be a challenge in patients with narrow palpebral fissures, narrow or floppy eyelids, and patients with deep-set eyes.

the dslt procedure is carried out in the doctor's office while the patient sits in front of the dslt device (termed the "eagle" device) for couple of minutes. in this procedure, 120 laser applications are performed around the full circumference of the ocular limbus, after the system automatically recognizes the limbal target area. it is therefore essential that a full exposure of 3600 limbal area will be achieved, and this is done by placing an eye lid retractor (speculum) in the treated eye at the beginning of the procedure. the purpose of this study is to evaluate the compatibility of different types of lid retractors. the lid retractors will be tested in adult volunteers visiting the study eye clinic for any reason.

Eligibility criteria:
inclusion criteria. * adult volunteers (age ≥18 years old) of both sexes visiting the study eye clinic for any reason. * willing and able to participate in the study and to comply with the study procedures. * participant capable of giving informed consent. exclusion criteria: * prior incisional ocular surgery or ocular trauma in the tested eye. * women who are pregnant. * any medical condition that interferes with the subject's ability to sit steady in front of the eagle device. * known allergy to local anaesthesia eye drops.
intravascular ultrasound for hepatocellular carcinoma staging

Conditions: Hepatocellular Carcinoma

Summary: to diagnose hepatocellular carcinoma (hcc) and to determine the extent of the disease, a triphasic ct scan or a magnetic resonance imaging are required. the characterization of hepatic nodules is more difficult when the hcc lesions have a diameter of less than 2 cm. since accuracy in the assessment of the number and the size of hcc nodules, as well as of the invasion of blood vessels is crucial to determine outcome after liver transplantation due to tumour recurrence, there is a need for techniques with a higher definition potential. as a consequence, to improve outcome and to optimize organ allocation, patients on the liver transplantation waiting list might benefit from intravascular ultrasound as an additional examination to complete the pre-transplant tumour staging process.


Eligibility criteria:
inclusion criteria: * hepatocellular carcinoma nodules * patient on liver transplantation waiting list * written informed consent exclusion criteria: * thrombosis of hepatic veins or vena cava

Keywords: hepatocellular carcinoma liver transplantation staging intravascular ultrasound
circadian variation in serum-progesterone levels following controlled ovarian hyperstimulation.

Conditions: Infertility

Summary: the aim of the study is to investigate the circadian variation in serum-progesterone in women undergoing controlled ovarian stimulation.


Eligibility criteria:
inclusion criteria: women undergoing standard ivf/icsi treatment. exclusion criteria: previous participation in the study.
protective effects of dexmedetomidine on myocardial injury during liver transplantation

Conditions: Evidence of Liver Transplantation; Myocardial Injury

Summary: the purpose of this study was to evaluate the protective effect of dexmedetomidine on myocardial injury during liver transplantation

liver transplantation surgery may lead to myocardial injury. dexmedetomidine, a highly specific α2-adrenoeptor agonist, has sedative and analgesic properties without significant respiratory depression at the clinically approved dosage. some investigations indicated that dexmedetomidine was able to protect the myocardium via improving the activity of na+-k+-adenosine triphosphate enzyme and ca2+-adenosine triphosphate, alleviating inflammation reaction and avoiding ca2+ overload. however, the effect and the mechanism of dexmedetomidine on myocardial injury during liver transplantation remain unclear.

Eligibility criteria:
inclusion criteria: * end stage liver disease scheduled for liver transplantation in tianjin first center hospital exclusion criteria: * pre-existing respiratory failure,renal failure,hepatic encephalopathy

Keywords: dexmedetomidine
the role of gastric content microaspirations in the pathogenesis of idiopathic pulmonary fibrosis

Conditions: IDIOPATHIC PULMONARY FIBROSIS

Summary: the pathogenesis of idiopathic pulmonary fibrosis (ipf) is debatable. looking for an insult to lung parenchyma that generates the pathogenesis of the disease is challenging. pepsin is a proteolytic enzyme present in the gastric juice. microaspirations of gastric content were described as a potential factor for injury in many chronic lung disorders. bronchoalveolar lavage (bal) is a routine investigation technique in interstitial lung diseases. the presence of pepsin in the bal fluid recovered from patients with ipf may indicate a possible role for gastric microaspirations in the pathogenesis of the disease.


Eligibility criteria:
inclusion criteria: * patients with interstitial lung disorders including ipf exclusion criteria: * patients younger than 18 years or older than 85, * pregnant women, * patients that present with medical conditions contra -indicated for performing bronchoscopy including sedation

Keywords: idiopathic pulmonary fibrosis microaspiration
an adjunctive family intervention for individual posttraumatic stress disorder treatment

Conditions: Posttraumatic Neuroses

Summary: this study aims to test a brief family intervention (the bfi) to enhance individually-delivered ptsd treatment for veterans.

the investigators will enroll pairs of veterans and one adult family member who lives with them. veterans will be beginning a course of ptsd-focused treatment at the boston va; veterans' treatment will not be limited or changed by their participation in this study. family members will receive or not receive (depending on which phase of the study they are recruited in) the bfi. the bfi consists of 2 sessions in which the family member meets one-on-one with a clinician to discuss ptsd, ptsd treatment, and how families can be most helpful to patients in treatment. veterans and family members will also be interviewed about their opinions and experiences regarding family-inclusive treatment for ptsd. clinicians will be recruited and enrolled to obtain their information and feedback (via qualitative interviews), and to deliver the intervention in phase ii.

Eligibility criteria:
inclusion criteria: * veterans must have a diagnosis of ptsd and be beginning a course of prolonged exposure (pe) or cognitive processing therapy (cpt) at the boston va. * must also have an eligible family member who is willing to participate. exclusion criteria: * current diagnosis of unstable bipolar disorder, substance dependence, past or present psychosis, or organic mental disorder * clear and current suicidal risk * current participation in family/couples therapy
non-invasive assessment of colonic motility

Conditions: Colon Disease; Functional Constipation; Electroenterography; Slow Transit; Hirschsprung Disease

Summary: the current diagnostic process of colonic motility disorders often takes a long time and involves multiple invasive, painful and/or unnecessary diagnostic procedures. to improve this diagnostic process, the potential of electro-entero-graphy (eeng) is investigated. during the eeng procedure, several surface electrodes are positioned (under ultrasound guidance) on the abdomen so that electrical activity originating in the colon can be measured. measurements will be performed after a period of fasting (when the colon is 'silent') and just after a meal (when the colon is moving) in both participants suffering from colonic motility disorders and healthy controls. it is hypothesized that these measurements are an indication of colonic motility and can be used as a diagnostic tool for colonic motility disorders. it is also hypothesized that this eeng procedure is not more burdensome than the gold standard procedures for diagnosing colonic motility disorders. this will be assessed using questionnaires.


Eligibility criteria:
inclusion criteria: * all participants: * age ≤ 11 years for babies and children * age ≥ 18 years for adults. patients * for babies/children: * suffering from surgically untreated hscr as determined by a rectal biopsy, or * suspected of hscr, for which a rectal biopsy is planned * for adults: suffering from a (suspected,) surgically untreated functional colonic motility disorder (such as slow-transit constipation, idiopathic/therapy resistant constipation of the colon), as diagnosed previously or will be diagnosed in the near future using the gold standard method. exclusion criteria: * all participants: * for adults: bmi \> 27 kg/m2 * for babies/children: weight for length \> 2.5 standard deviations of who child growth standard * pregnancy * diabetes * any food intolerance * presence of an intestinal stoma * use of continuous tube feeding * healthy controls: * the presence of any known gastro-intestinal conditions * use of laxatives in the past two years * participants with (suspected) motility disorder: * (part of) colon removed * inflammatory bowel disease
safety and efficacy comparison study of nk-104-cr (controled release) in patients with primary hyperlipidemia or mixed dyslipidemia

Conditions: Hyperlipidemia; Dyslipidemia

Summary: the purpose of this study is to compare the efficacy of nk-104-cr with placebo and livalo® on the reduction of ldl-c and to evaluate the safety of nk-104-cr in patients with primary hyperlipidemia or mixed dyslipidemia


Eligibility criteria:
inclusion criteria: * male and female patients with primary hyperlipidemia or mixed dyslipidemia who are ≥18 and ≤80 years of age at the time of consent; * fasting plasma ldl-c ≥160 mg/dl and ≤250 mg/dl and tg values of ≤300 mg/dl * patients who are naïve to statin or who are able to safely discontinue the use of all lipid-lowering agents for 6 weeks before randomization and throughout study participation exclusion criteria: * homozygous familial hypercholesterolemia; * any conditions which may cause secondary dyslipidemia. * newly diagnosed or poorly controlled diabetes mellitus as defined by hba1c \>8%