Kornimate/medical-research-clean huggingface dataset:
kap of dental practitioners regarding cra

Conditions: Caries,Dental; Tooth Decay; Tooth Diseases

Summary: the aim of the study is to evaluate the knowledge, attitude, and practice of a group of dental practitioners from cairo and riyadh regarding caries risk assessment and management.

dental caries is a preventable major public health disease affecting people of all ages and substantially impacting overall health. caries remain the single most common chronic childhood disease. dental caries is a dynamic and complex process. several variables influence the occurrence of dental caries, including oral flora, saliva flow and composition, and lifestyle. dental caries development can be primary (new carious lesion) or secondary (lesion progression or reactivated carious lesions). there has been much progress over the past several decades in the prevention of dental caries, shifting from the management of dental caries from a "surgical approach" to a "medical prevention strategy", based on a better understanding of the caries disease process. caries risk assessment (cra) is a significant part of successfully applying the minimum intervention dentistry philosophy in managing dental caries. as recommended by aapd, dental caries-risk assessment should be a routine component of new and periodic examinations by oral health and medical providers. therefore, this study aims to assess the knowledge, attitude, and practice of a group of dental practitioners from cairo and riyadh regarding caries risk assessment and management. benefits to practitioner: * increasing awareness of the importance of cra practices. * implementing a positive attitude regarding cra and management. * improve practices toward cra benefits to patient: * increasing the awareness and knowledge of early caries prevention by dentists. * increasing awareness about caries risk assessment and management. benefits to community: • increasing the knowledge and awareness of the community regarding preventive dentistry and the importance of primary prevention

Eligibility criteria:
inclusion criteria: * licensed egyptian and saudi general dentists. exclusion criteria: * undergraduate dental students * dental specialists * dentists who refused to participate

Keywords: caries risk assessment caries prevention general practitioners
future 3 study extension

Conditions: Pulmonary Arterial Hypertension

Summary: the objectives of the future 3 study extension are to evaluate the long-term safety, tolerability and efficacy of the pediatric formulation of bosentan two versus three times a day in children with pulmonary arterial hypertension (pah).


Eligibility criteria:
inclusion criteria: 1. patients who completed the future 3 core study (ac-052-373) or prematurely discontinued due to pah-progression, if bosentan was not permanently discontinued 2. patients who tolerated bosentan pediatric formulation and for whom bosentan is considered beneficial at the end of the future 3 core study (ac-052-373) 3. signed informed consent by the parents or the legal representatives prior to any study-mandated procedure. exclusion criteria: 1. known intolerance or hypersensitivity to bosentan or any of the excipients of the dispersible bosentan tablet 2. any clinically significant laboratory abnormality that precludes continuation of bosentan therapy 3. pregnancy 4. ast and/or alt values \> 3 times the upper limit of normal range (uln) 5. moderate to severe hepatic impairment, i.e., child-pugh class b or c 6. premature and permanent study drug discontinuation during the future 3 core study (ac-052-373) 7. any major violation of the future 3 core study (ac-052-373) protocol.

Keywords: pediatric pulmonary arterial hypertension bosentan tracleer
superno2va™ and general anesthesia postoperative care

Conditions: Hypoxemia; Acute Respiratory Failure

Summary: the purpose of the study is to randomly and prospectively evaluate the differences in outcomes between the control group (closed full facemask immediate post-extubation with standard oxygenating device used post-operatively in pacu) and the superno2va™ group (superno2va™ immediate post-extubation and post-operatively in pacu)


Eligibility criteria:
inclusion criteria: 1. age 18 years of age or older 2. patients scheduled for general anesthesia with a supraglottic device or ett 3. american society of anesthesiology (asa) physical status i-iv (e) 4. has provided written informed consent 5. bmi \> 35 kg/m2 or documented obstructive sleep apnea exclusion criteria: 1. inability to give informed consent 2. asa v (e) 3. allergy to propofol 4. any condition, in the investigator's opinion, that would conflict or otherwise prevent the subject from complying with study required procedures, schedule or other study conduct 5. bmi \< 35 kg/m2 with no documented diagnosis (known) of obstructive sleep apnea 6. known diagnosis of moderate to severe copd/lung disease 7. patients that remained intubated post-operatively 8. patient refusal to wear the treatment device (superno2va™, nasal cannula, or oxygen facemask) for the duration of the study period postoperatively
restricted vs. free knee range of motion for primary traumatic patellar dislocation

Conditions: Patellar Dislocation

Summary: knee immobilization in near extension has been proposed as a nonoperative treatment for primary traumatic patellar dislocation, although there exist no prospective studies regarding the method of immobilization. the objective of this prospective randomized study was to compare the clinical outcome after nonoperative treatment with restricted vs. free range of motion (rom) for primary traumatic patellar dislocation.


Eligibility criteria:
inclusion criteria: * a primary (first-time) patellar dislocation verified by clinical examination * signs of patellar dislocation in mri exclusion criteria: * anyone with previous patellar instability * osteochondral fracture requiring surgery * associated knee injuries

Keywords: patella knee brace
loc387715/htra1 and the combined photodynamic therapy with intravitreal bevacizumab in polypoidal choroidal vasculopathy

Conditions: Age-Related Macular Degeneration

Summary: this study is to investigate whether there is an association of the loc387715/htra1 variants with response to treatment with combined photodynamic therapy and intravitreal bevacizumab for patients with polypoidal choroidal vasculopathy.

this is a retrospective cohort study comprised of 70 eyes being treated for polypoidal choroidal vasculopathy with combined photodynamic therapy and intravitreal bevacizumab injections. patients were genotyped for the loc387715 (rs10490924) and the htra1 gene polymorphism (rs11200638).

Eligibility criteria:
inclusion criteria: * patients older than 60 years of age at onset * polyp-like terminal aneurysmal dilations with or without branching vascular networks in indocyanine green angiography (icga) and subretinal reddish-orange protrusions corresponding to polyp-like lesions * patients who had combined photodynamic therapy and intravitreal bevacizumab injections, and followed up for more than 12 months after the first treatment exclusion criteria: * patients with retinal or choroidal diseases including pathologic myopia, angioid streaks, idiopathic choroidal neovascularization (cnv), presumed ocular histoplasmosis, and other secondary cnv * patients who refused genotypic analyses
treatment of infertility by collagen scaffold loaded with umbilical cord derived mesenchyma stem cells

Conditions: Infertility; Intrauterine Adhesions

Summary: study of the treatment of infertility caused by recurrent intrauterine adhesions (iua) by collagen scaffold loaded with umbilical cord derived mesenchymal stem cells (uc-mscs) to provide clinical evidence of safety and effectiveness for the treatment of uterine infertility.

infertility is defined as a women fails to become pregnant after having a normal sex life for two years without contraception. there is limited treatment to the infertility caused by severe iua especially recurrent iua after adhesiolysis which hinders embryos implantation. the existing drugs, physical or surgical treatments had no significant effects to severe recurrent intrauterine adhesions. collagen is the main component of the extracellular matrix with good biocompatibility, uc-mscs have been used in the clinical treatment of diseases, and achieved good results. in this study, collagen scaffold and umbilical cord blood-derived mesenchymal stem cells are combined, and they showed good biological safety.

Eligibility criteria:
inclusion criteria: * secondary infertility or failure of embryo transfer caused by recurrent intrauterine adhesions who desired to be pregnant * hysteroscopy examination confirmed intrauterine adhesions * sign a consent form * follow the test plan and follow-up process exclusion criteria: * have hysteroscopic contraindications * chromosome karyotype abnormalities * congenital uterine malformations * severe adenomyosis * contraindications to estradiol treatment * medical history of pelvic tumors or receiving pelvic radiotherapy
efficacy and safety of perlane-l in the correction of midface volume deficit

Conditions: Facial Volume

Summary: the purpose of this study is to determine if perlane-l is safe in increasing cheek volume.


Eligibility criteria:
inclusion criteria: * loss of fullness in midface area * other items as identified in the protocol exclusion criteria: * history of allergy or hypersensitivity to injectable hyaluronic acid gel or lidocaine. * other items as identified in the protocol
the cardiovascular changes associated with septal local anaesthesia

Conditions: Hypothalamic Neoplasms; Pituitary Diseases; Anesthesia, Local

Summary: the purpose of this study is to determine the effects on the heart of injecting local anaesthetic into the nose prior to surgery on the pituitary gland?

people sometimes require surgery on their pituitary gland. this is a gland at the base of your brain which secretes hormones. at the royal hallamshire hospital the investigators are currently conducting a study into the effects of local anaesthetic (a medicine which causes numbness) injection on patients undergoing this particular type of operation. after patients are anaesthetised (asleep) but before surgery starts the surgeon injecst a local anaesthetic solution into the nose. this is routine practice and is done to provide pain relief afterwards and also to decrease the amount of bleeding during the operation to ensure that the surgeon has a good view. the investigators have known for a long time that local anaesthetic affects the heart rate and blood pressure, however the investigators would like to describe exactly how, in much more detail.

Eligibility criteria:
inclusion criteria: * any adult patient undergoing trans-sphenoidal pituitary surgery. exclusion criteria: * under 16 years of age, pregnancy, uncontrolled hypertension, allergy to any local anaesthetic, patient refusal or revision pituitary surgery.
the prevalence of vitamin d deficiency in patients with alzheimer's disease

Conditions: Alzheimer's Disease

Summary: recent studies indicate that there is a relationship between cognitive decline and vitamin d deficiency. up to now, no study has investigated the prevalence of vitamin d deficiency in patient with alzheimer's disease. our aim is to investigate the prevalence of vitamin d deficiency and analysis the associated characteristics in patients with alzheimer's disease.

vitamin d has many physiological functions via skeletal and extra-skeletal effects. nowadays, it is well known that vitamin d deficiency causes to an increase in disease burden. as the role of vitamin d, the maintenance of balance, the improvement of muscle power, and the augmentation of innate immunity were proven. some recent studies showed that vitamin d deficiency associates with cardiovascular diseases, autoimmune diseases, and the risk of cancer. vitamin d carries out your functions by vitamin d receptors (vdr) located in many cells. brain neurons and glial cells are including vdr's. it is presumed that the functions of vitamin d in neurons are the regulation of neurotransmission, neuron protection, and immunomodulation. also,vitamin d has a role in brain development and maturation. except the functions in central nerve system, vitamin d has effects on peripheral nerve system. it was reported that nerve transduction velocity decreased in vitamin d deficiency. vitamin d deficiency and alzheimer's disease are major public health problems that their incidences increase in advanced ages.recent studies indicate that there is a relationship between cognitive decline and vitamin d deficiency. vdr receptors in brain specially in hippocampus, hypothalamus, limbic system, subcortical and spinal motor areas were determined. up to now, no study has investigated the prevalence of vitamin d deficiency in patient with alzheimer's disease. our aim is to investigate the prevalence of vitamin d deficiency and analysis the associated characteristics in patients with alzheimer's disease.

Eligibility criteria:
inclusion criteria: * the patient must have alzheimer's dementia and their diagnosis must be made according to national institute of neurological and communicative disorders and stroke and the alzheimer disease and related disorders association (nincds/adrda) and dsm-iv criteria * the informed consent form must be given by patients and/or their representatives exclusion criteria: * if the causes of dementia (lewy body dementia, vascular dementia, pick disease, frontotemporal dementia...) is out of alzheimer's dementia, * having chronic liver disease and/or end-stage renal disease * if the informed consent form is being withdrawn

Keywords: vitamin d deficiency alzheimer's disease
coronary flow reserve evaluation in pet and in mri scanner in heart transplanted patients : comparison with multi-detectors scanner

Conditions: Heart Disease

Summary: heart transplantation is the ultimate therapeutic option in patients with end-stage heart failure. since advances in the treatment of acute rejection has increased early transplant survival, cardiac allograft vasculopathy (cav) is the main factor limiting long-term survival. the prevalence of angiographically proven cav is high, documented in 40-50% of transplant recipients 5 years after transplantation. therefore, annual coronary angiography remains widely used to monitor transplanted patients, although pathologic studies and intravascular ultrasonography have demonstrated that coronary angiography underestimates the severity of cav. perfusion spect may underestimate allograft vasculopathy in case of diffuse coronary lesions. in this setting, the assessment of coronary reserve by means of positron emission tomography (pet) and perfusion cardiac magnetic resonance imaging (cmr) have not been investigated.

aim of the study. the aim of the study is to compare the quantitative (using 15o-h2o pet) and semi-quantitative (using perfusion cmr) assessment of coronary reserve to the presence of coronary artery lesions documented by multidetector ct coronary angiography. methods. 30 patients with heart transplantation \> 3 yrs will be included in two heart transplantation centers (caen and rouen university hospitals) expected results. * to demonstrate that quantitative analysis of coronary reserve using 15o-h2o pet allows the assessment of cardiac allograft vasculopathy * to establish the feasibility of adenosine stress cmr in this population * to show a relationship between coronary lesions demonstrated using mdct and the extent of coronary reserve impairment assessed using cardiac functional imaging (pet and cmr).

Eligibility criteria:
inclusion criteria: * patient with heart transplantation \> 3 years * candidate to a routine coronary angiography * age \> 18 years old * signed informed consent exclusion criteria: * pregnancy or breast feeding women * recent acute coronary syndrome (\<4weeks) * high blood pressure ((sbp \>=180 mmhg or dbp \>=110 mmhg) * significant ventricular or supraventricular arrythmia * atrioventricular 2nd or 3rd degree blocks, long qt syndrome * standard contraindications to mri including pacemaker/defibrillator, metallic clips on brain aneurysms, metal fragment in the eye etc... * congestive heart failure * hemodynamic instability * intolerance or contraindication to adenosine (history of asthma or bronchoplastic disease). * severe and known pulmonary artery hypertension * severe hypotension \< 90 mmhg * contraindication to contrast iodinated media (allergy, patients with chronic renal failure with creatinine clearance \< 50 ml/min, multiple myeloma, hyperthyroidism,...)

Keywords: heart transplantation
study to assess the effect of dosing azd6244 hydsulfate in the presence and absence of food in patients with advanced solid malignancies

Conditions: Melanoma; Malignant Melanoma

Summary: the purpose of this study is to test if the levels of azd6244 in blood are affected by taking food at the same time as the capsules compared to taking capsules on an empty stomach


Eligibility criteria:
inclusion criteria: * able to eat a high fat breakfast within a 30-minute period * advanced cancer which is refractory to standard therapies, for which no standard therapies exist * who or ecog performance status 0-2 (those with performance status 2 must have been stable with no deterioration for over 2 weeks) exclusion criteria: * any radiotherapy or chemotherapy within 21 days prior to starting the study treatment (not including palliative radiotherapy at focal sites). * any evidence of severe or uncontrolled systemic disease (eg., severe hepatic impairment, severe renal impairment, uncontrolled diabetes, acute uncontrolled infection) or current unstable or uncompensated respiratory or cardiac conditions or peripheral vascular disease including diabetic vasculopathy. * refractory nausea and vomiting, chronic gi diseases (eg., inflammatory bowel disease) or significant bowel resection that would preclude adequate absorption.

Keywords: melanoma phase i azd6244
reduction of breast hypertrophy by means of coelioscopique surgery

Conditions: Breast Reduction

Summary: the objective of this interventional study is based on the hypothesis that coelioscopique surgery could be used to reduce breast hypertrophy. this study can be expected to scientifically validate the use of laparoscopic surgery to obtain a clinical result in the context of reduction of medium volume breast hypertrophy.

breast reductions are common procedures. one of the main difficulties related to this surgery remains the healing, wide at the peri-areolar level, vertical at the sub-areolar level and in the sub-mammary fold. in addition, this intervention remains subject to the vagaries of hypertrophic or even keloidal healing, especially in young subjects. on this study can be expected to scientifically validate the use of laparoscopic surgery to obtain a clinical result without scarring in the context of the reduction of medium volume breast hypertrophy. ultimately, the results of this study may serve as a basis for further research by proposing: * prophylactic mastectomies and immediate breast reconstruction without lateral scar and with a less visible sub-breast scar. * a breast reduction in young patients before the skin undergoes the effects of the heaviness of the breasts.

Eligibility criteria:
inclusion criteria : * women over the age of 18. * category 1 or 2 according to the regnault classification. * c cup breast size or larger. * areola "looks ahead" i.e. a distance between point a (at the top of the areola) at the median suprasternal point of approximately 16 cm to 24 cm. * ptosis (distance between the lowest part of the breast and the submammary fold) of a maximum of 7cm (measured in a seated position). * expected correction of half ptosis with decrease of 1 to 3 cup sizes. * patient has good quality thick skin. * social security scheme. * patient requesting breast reduction. * patient having signed the free and informed consent. non inclusion criteria : * areola "look down"; point a more than 25 cm. * ptosis greater than or equal to 8 cm. * thin skin. * smoker. * patient under effects of anti-coagulant. * patient participating in another clinical study. * protected patient: adults under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision. * pregnant, lactating woman.
effects of whole-body vibration exercise on serum igf-1 in fibromyalgia

Conditions: Fibromyalgia; Hormonal Responses to Exercise in Patients With Fibromyalgia.

Summary: the purpose of this study was to investigate the acute and chronic effect of whole-body vibration exercise on serum insulin-like growth factor-1 levels in women with fibromyalgia (fm). it was hypothesized that women with fm would exhibit an increase in igf-1 following both acute and chronic wbv. twenty-four women with fm were randomized into two groups: vibration group (vg) and control group (cg). the vg underwent a protocol with wbv exercise twice a week for a total of six weeks, whereas the cg performed the same protocol without vibratory stimulus. both groups continued with their usual pharmacological treatment. serum igf-1 levels were determined using enzyme-linked immunosorbent assay (elisa). to test the effect of chronic wbv, serum igf-1 measurements were taken at baseline and at weeks 1,3, and 6 of intervention. to test the effect of acute wbv, within week 1, serum igf-1 measurements were taken before and immediately following a session of wbv.


Eligibility criteria:
inclusion criteria: * patients diagnosed of fibromyalgia according to the american college of rheumatology criteria for at least three years. exclusion criteria: * orthopedic limitation, or cardiovascular, pulmonary, or metabolic disease that would preclude exercise. * participation in any other study.

Keywords: fibromyalgia whole-body vibration exercise igf-1
tapentadol versus oxycodone - a mechanism-based treatment approach in neuropathic pain

Conditions: Peripheral Neuropathy

Summary: the purpose of this study is to elucidate whether the additional mechanism of analgesia, i.e. reuptake inhibition of norepinephrine, of tapentadol leads to a change in different pain signs and symptoms in comparison to oxycodone.


Eligibility criteria:
inclusion criteria: * thermal or mechanical hyperalgesia * chronic neuropathic pain (nrs =\> 6) exclusion criteria: * non-specific

Keywords: qst (quantitative sensory testing) neuropathic pain tapentadol pr oxycodone