Kornimate/medical-research-clean huggingface dataset:
effects of remote cardiac ischemic preconditioning

Conditions: Cardiac Function and Preconditioning

Summary: a heart attack occurs when blood flow is disrupted to the heart and is related to both the blockage and flow restoration (reperfusion injury). an occlusion during a heart attack can be cleared (mostly via stents), but there are no methods to decrease reperfusion injury even though animal studies have found that "preconditioning" has powerful protective effects. through the observation of jewish men wearing tefillin the investigators have discovered a method of bringing preconditioning to patients at risk for heart attacks. this study will focus on women as the majority of people who wear tefillin (and have been studied) are men.

remote ischemic preconditioning (ripc) is a process via which short bursts of ischemia result in dramatic subsequent protection in remote organs from a prolonged ischemic injury such as myocardial infarction from reperfusion injury. the translation of ripc stimuli to clinically relevant therapies has not been successful as almost all prior research on ripc (animal and human) involved the full blockage of blood flow to an organ or extremity (in humans commonly with full inflation cycles of a blood pressure cuff). our laboratory's key translational insight involved the jewish tradition of donning tefillin (phylacteries) that is traditionally worn on an almost daily basis by jewish orthodox men on the non-dominant arm in a non-obstructive manner (nob). my laboratory has made substantial progress by demonstrating that tefillin induced nob induces an ripc phenotype in healthy (mostly) men. the overarching hypothesis of this proposal is that full arm nob via tefillin results in a preconditioning stimulus in women that is sufficient to induce an ripc phenotype. the sole aim will test the hypothesis that full arm nob (in healthy females) results in an inducible ripc phenotype that increases over time as measured via clinically relevant variables derived from heart rate variability monitoring and inflammatory markers.

Eligibility criteria:
inclusion criteria: * females over 18 years of age exclusion criteria: * current medication use for medical condition or active medical condition
comparison of bacterial contamination rates between isolation and non-isolation rooms

Conditions: Methicillin-Resistant Staphylococcus Aureus

Summary: this study is to determine if medication cabinets located outside of isolation rooms in hospitals and their contents, particularly medications and the delivery folders are at a higher risk of having harmful bacteria on them.

studies show high touch areas maybe contaminated with organisms such as methicillin-resistant staphylococcus aureus(mrsa) and vancomycin-resistant enterococci. mrsa can live on hospital surfaces for 9-14 days. patients in rooms that were previously mrsa isolation rooms are at higher risk for developing a hospital-acquired infection. this study is to determine if medication cabinets located outside of mrsa isolation rooms and their contents, particularly medications and the pharmacy delivery folders are at a higher risk of having mrsa colonization on them. this study will use conventional methods to determine if mrsa colonization is present and compare results between non-isolation and isolation rooms. this will evaluate if alternate measures for the reduction of mrsa colonization are needed for the mrsa isolation rooms in regards to medication delivery and storage.

Eligibility criteria:
inclusion criteria: * patient rooms with isolation status for mrsa * patient rooms without isolation status for mrsa for 14 days exclusion criteria: * rooms without medication cabinets directly outside the room

Keywords: mrsa contamination isolation
a prospective study to evaluate continuous positive airway pressure devices to reduce pulmonary dose

Conditions: Lung Cancer; Left Sided Breast Cancer

Summary: data collection and assessment on patients with left-sided breast cancer or undergoing lung stereotactic body radiation therapy (sbrt) utilizing continuous positive airway pressure (cpap) devices.

lung stereotactic body radiation therapy (sbrt) has emerged as a definitive treatment for patients with early-stage lung cancers as well as for patients with limited metastases to the lung. one challenge with the treatment of the lung is the risk of pulmonary toxicity, particularly for early-stage lungs cancers that are inoperable (those receiving primary lung sbrt) or those with metastatic cancers receiving systemic therapy that may impact pulmonary function (those receiving lung sbrt for metastatic cancers). continuous positive airway pressure (cpap) devices are commonly utilized for patients with obstructive sleep apnea. however, through the use of continuous pressure, lung volumes are increased. preliminary data in patients undergoing breast radiation as well as lung radiation has demonstrated the safety and feasibility of such an approach, demonstrating increased lung volumes with decreases in heart dose6-8. additional potential advantages of cpap include increased ease of use for patients and the potential for cost savings as compared to traditional respiratory management techniques. this prospective study is to allow for the collection and assessment of data on patients with left-sided breast cancer or undergoing lung sbrt utilizing cpap. this will allow for the assessment of lung doses with and without cpap as well as cardiac doses. no additional changes to our standard of care breast or lung radiation will occur. with respect to the safety profile, cpap is commonly used with limited toxicity concerns. the potential benefit of cpap has reduced lung and heart doses and, consequently, radiation-related toxicities.

Eligibility criteria:
inclusion criteria: * patients with left-sided breast cancers * patients must be undergoing left breast/chest wall radiation with or without regional nodal irradiation * patients undergoing lung sbrt * primary lung cancers * metastatic lung tumors exclusion criteria: * patients with right side breast cancer * patients who are unable to tolerate the cpap device

Keywords: stereotactic body radiation therapy continuous positive airway pressure cpap radiation cancer lung deep inspiratory breath hold (dibh)
treatment of acute exacerbation of chronic obstructive pulmonary disease with qingkepingchuan granules clinical observation of phlegm-heat and lung depletion

Conditions: Chronic Obstructive Pulmonary Disease

Summary: through the clinical observation of qingcheng pingxian granules in the treatment of acute exacerbation of chronic obstructive pulmonary disease (phlegm-heat lung syndrome), (1) to evaluate the safety of qingcheng pingxian granules in the acute exacerbation of chronic obstructive pulmonary disease; (2) to observe the clinical efficacy of qingcheng pingxian granules in the treatment of acute exacerbation of chronic obstructive pulmonary disease, to provide an effective medication and solution for the treatment of acute exacerbation of chronic obstructive pulmonary disease, and to provide data for the development of the further application of qingcheng pingxian granules.


Eligibility criteria:
inclusion criteria: 1. meet the diagnostic criteria of aecopd. 2. chinese medicine diagnosis is consistent with phlegm-heat and lung depletion evidence 3. 40 years old ≤ age ≤ 90 years old 4. patients who signed the informed consent form and volunteered to participate in the study exclusion criteria: 1. combined with other primary lung diseases such as bronchial asthma, bronchiectasis, etc. 2. combination of serious cardiovascular, urinary, digestive, haematopoietic, endocrine metabolic system diseases, other psychiatric and neurological diseases. 3. pregnant or lactating patients. 4. allergic to the clinical trial drugs.
outcomes in patients with myeloproliferative neoplasm and splanchnic vein thrombosis

Conditions: Myeloproliferative Neoplasm; Splanchnic Vein Thrombosis; Splanchnic Venous Thrombosis; Myeloproliferative Disorders

Summary: patients with myeloproliferative neoplasms are at particular risk for developing arterial and venous thrombosis, especially thrombosis in the splanchnic venous system. the patho-physiology and natural history of mpn related svt is poorly understood and treatment algorithms vary greatly. this is of considerable importance since the morbidity and mortality in this group of patients is high. this study aims to observe patients with mpn related svt over a period of five years to document their clinical progress. methods of observation include clinical assessment, standard investigations and laboratory based research investigations

study title morbidity and portal circulation in patients with myeloproliferative neoplasms and splanchnic vein thrombosis: mascot protocol no. mpn-svt v11; 02/dec/2013 study design prospective observational longitudinal study of patients with mpn related splanchnic vein thrombosis(study group) and patients with mpn without svt (control group) study participants patients with myeloproliferative neoplasms (mpn) and splanchnic vein thrombosis (svt), patients with mpn and splenomegaly. number of subjects 40 patients follow-up duration 5 years study duration january 2014- january 2019. primary objectives 1. to describe morbidity/portal circulation in the patient group over the 18m from baseline 2. to examine if there are changes in endpoints from baseline to 18m 3. to compare patients with mpn related svt and mpn without svt secondary objectives 1. to describe morbidity/portal circulation in the patient group over 5 years from baseline 2. to examine if there are changes in endpoints from baseline to 5 years 3. to assess the impact of treatment including cytoreductive therapy, janus kinase (jak) inhibition and antithrombotic treatment on end points. 4. to assess adequacy of anti-thrombotic agents with reference to recurrence, recanalisation and extension of splanchnic thrombosis, non-splanchnic thrombotic events and bleeding frequency. exploratory objectives 1. assess the utility of endothelial colony assay as marker of disease 2. assess the utility of adhesion molecules as markers of disease primary endpoint composite end point comprising occurrence or change in morbidity or portal circulation over 18 months secondary endpoint occurence or change in morbidity or portal circulation over 3-5 years

Eligibility criteria:
inclusion criteria: 1. mpn with svt between 3 weeks to 5 years of diagnosis of svt: study arm 2. mpn with palpable splenomegaly or enlarged by ultrasound: control arm exclusion criteria: age \<18 years patients with svt without mpn

Keywords: thrombosis splanchnic anticoagulation tipss myeloproliferative
comparing adjustable sutures surgery

Conditions: Strabismus, Comitant

Summary: adjustable suture surgery will be done in patients with horizontal strabismus comparing the time of adjustment

forty patients will be equally divided into two groups and time of adjustment of the suture will be compared as regards efficacy and pain tolerance

Eligibility criteria:
inclusion criteria: * more than 16 years old patients comitant esodeviation and exodeviation 15-45 prism diopters cooperative patients exclusion criteria: * patients with previous strabismus surgery patients with oblique deviations
suicide risk assessment by digital means

Conditions: Suicide

Summary: this study is an observational study, without intervention. using a tablet application that developed for this study. in addition, sensors are used to examine the possibility of using the system to assess the risk of suicide. it should be noted that this is a pilot study, only for a wider study involving a larger number of patients. the system developed for the benefit of this study is based on a smartphone application installed on a standard smartphone device that will be found in the ed or by the examiner. the system collects data from five channels one by one (the information collected from each channel is collected separately). the data recorded from the various channels is saved on the tablet device. then, the information transferred to the database using a cable. a statistical analysis of the data from the various channels is carried out in order to assess suicidal behavior. after the statistical analysis, correlations will be examining between the results of the measurements and the results of the accepted questionnaires for the assessment of suicidality, which will be performed simultaneously. note that the duration of participation is the duration of the measurements, ie a single session that lasts up to two hours the duration of the participants in the study is determined by the time of the measurements, ie a single session lasting up to two hours.


Eligibility criteria:
inclusion criteria: * every patient who is examined in the psychiatric ward at the sheba medical center * proper ability to give informed consent exclusion criteria: * a patient who is not independent and without an active therapist / guardian involved in the treatment
pulmonary microbiota and ards mortality

Conditions: Acute Respiratory Distress Syndrome

Summary: acute respiratory distress syndrome (ards) is due to diffuse and severe lung inflammation. despite intensive research, few therapeutics have emerged and treatment is still mostly symptomatic. as lung microbiota seems to be associated with lung inflammation in numerous chronic respiratory diseases, this study aims to analyse the correlation between lung microbiota and mortality.

ards is caused by diffuse intense lun inflammation. its mortality rate is still about 40%. despite decades of research, few therapeutics have emerged. treatment is based on the treatment of ards cause, if possible and on protective ventilation, curare use and prone position. for more severe cases, nitric monoxide inhalation and extra-corporeal membrane oxygenation can be considered. nevertheless, no treatment specifically addresses lung inflammation. lung microbiota has been shown to be associated with lung inflammation in asthma, chronic obstructive disease and cystic fibrosis. lung microbiota also plays a role in lung immunity. regarding specifically ards, one study correlated lung microbiota with the occurrence of non-infectious ards in trauma patients. thi study therefore aims to analyse the correlation between lung microbiota at admission to icu for ards with mortality.

Eligibility criteria:
inclusion criteria: * patient above 18 year-old admitted to intensive care unit * ards according to berlin criteria * needing oro-tracheal intubation for mechanical ventilation * within the first 48 hours of ards evolution exclusion criteria: * guardianship or curatorship * prisoners * no health insurance * no legal representative

Keywords: acute respiratory distress syndrome microbiota intensive care unit
cannabis and parkinson's disease tremor: a natural history study

Conditions: Parkinson's Disease

Summary: this is a prospective, observational study designed to describe the effects of cannabis on parkinson's disease tremor.

ten individuals with parkinson's disease (pd) and tremor who use cannabis were observed for two weeks. individuals were asked to keep a journal of cannabis use (form, delivery method, amount) and wear an accelerometer on the wrist with the dominant tremor. analyses will be performed to describe whether cannabis use affects pd tremor following use.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of parkinson's disease * presence of pd-related tremor * currently using cannabis for management of tremor * obtaining cannabis in accordance with washington state law * willing to log activities and experiences * willing to wear a motion sensor * able to attend 2 on-site visits exclusion criteria: * presence of active infection within 5 days prior to enrollment * presence of unusual stressor within 5 days prior to enrollment * pregnancy
helena study: an observational study of perjeta (pertuzumab) in first-line treatment in patients with her2-positive advanced breast cancer after adjuvant herceptin therapy

Conditions: Breast Cancer

Summary: this observational study will evaluate the efficacy, safety and patient reported quality of life of palliative first-line perjeta (pertuzumab) in combination with herceptin (trastuzumab) in patients with her2-positive advanced breast cancer (metastatic or locally recurrent, inoperable) who relapsed after completed adjuvant herceptin therapy. additionally, information on selection criteria of breast cancer patients treated first-line with perjeta, herceptin and chemotherapy and their treatment duration will be collected and analyzed. data will be collected from eligible patients for up to 20 months of treatment and 24 months of follow-up.


Eligibility criteria:
inclusion criteria: * female adult patients, \>/= 18 years of age * her2-positive advanced breast cancer (metastatic or locally recurrent, inoperable) relapsing after completed adjuvant herceptin therapy * indication for first-line treatment with perjeta in combination with herceptin and chemotherapy according to the summary of product characteristics * prior herceptin therapy as systemic adjuvant treatment (postoperative treatment in a potentially curable setting); additional upfront neoadjuvant herceptin therapy is allowed * no prior chemotherapy and/or immunotherapy for advanced (metastatic or locally recurrent, inoperable) her2-positive breast cancer exclusion criteria: * pregnant or breastfeeding women * contraindications to perjeta, herceptin or concomitant chemotherapy according to the summary of product characteristics * no herceptin treatment for early breast cancer in the adjuvant setting
effects of resistive diaphragmatic training on chronic stroke

Conditions: Stroke (CVA) or TIA

Summary: to determine the effects of resistive diaphragmatic training on pulmonary function of chronic stroke patients. and also assessing their compromised respiratory functions

this study is to examine the effects of diaphragmatic breathing exercises with resistance and digital spirometer training for improving pulmonary functions in chronic stroke patients. diaphragmatic resistance training is based on the same principal as for the any other skeletal muscle training. the selection of 20 subjects divided equally and placed into an experimental group and a control group and the interventions would applied three times per week for 4 weeks. in each session, both groups receive digital spirometer training for 15 minutes. in addition, experimental group receive diaphragm breathing exercises with resistance for 30 minutes. resistance is applied through different thera bands and then performing the breathing exercises. first of all resistance applied through yellow band(1-6 pounds of resistance) and then red, green and black which give (4-18 pounds of resistance) the patient is asked to breath in deeply and slowly while not to move upper chest .weight increased weekly as per patient's tolerance. further digital spirometer training perform to determine the pulmonary functions fvc,fev1,fvc/fev1,pef,vc. in both control and experimental groups

Eligibility criteria:
inclusion criteria: * age limit 40-50yrs both genders. * stroke patients with compromised pulmonary functions. * chronic stroke patients with impaired breathing exclusion criteria: * patients having any systemic illness * patients who have a damage accompanying orthopedic disease such as thoracic deformation or rib fracture. * patients with stroke (less than 6 months duration)

Keywords: stroke resistive diaphragmatic training pulmonary function
in-use test with a cosmetic product to treat pruritus

Conditions: Pruritus

Summary: the aim of the study is to evaluate the cosmetic features of the product wo 3308 by means of a questionnaire in an interview situation after two weeks of product treatment, giving special consideration to the cosmetic performance, efficacy and skin compatibility and with special focus on the reduction of pruritus. additionally the tolerance will be evaluated by a dermatologist.


Eligibility criteria:
inclusion criteria: * age: ≥ 18 years * sex: approx. 25% to 50% male and 50% to 75% female * with acute pruritus (lasts less than 6 weeks) or chronic pruritus (lasts longer than 6 weeks): max. 50% with acute pruritus and at least 50% with chronic pruritus exclusion criteria: * any deviation from the above-mentioned criteria * known incompatibilities to cosmetics and ingredients of cosmetic test products (please see inci) * topical medication in the test area within 1 month prior to study start * systemic medication with antibiotics within 2 weeks prior to starting of the study * change in the medication with anti-inflammatory agents within 2 weeks prior to starting the study * systemic medication with immunomodulators (immunsuppressive drugs in the course of a transplantation) and/or chemotherapeutic agents within 4 weeks prior to starting the study * neurodermatitis (atopic dermatitis) * pregnancy and period of breastfeeding

Keywords: chronic pruritus acute pruritus
defeating urinary incontinence with exercise training (duet) feasibility study

Conditions: Toileting Disability; Functional Urinary Incontinence

Summary: pilot study to determine the feasibility and possible treatment effect of a multi-component intervention combining non-drug treatments for urinary incontinence and physical activity to improve urinary incontinence, toileting skills, physical function, and quality of life in frail older women without dementia living in senior housing facilities.

this was a single blinded, two-arm pilot randomized controlled trial designed to test the feasibility and potential treatment effects of a multi-component intervention that combined behavioral urinary incontinence treatments with physical activity to improve urinary incontinence, toileting skills, quality of life, and physical function in frail older women without dementia living in senior apartment buildings.the intervention included a 12-week program of tailored behavioral ui treatments delivered by a nurse practitioner during 4 home visits, 150 minutes of weekly walking, and twice weekly strength training classes.

Eligibility criteria:
inclusion criteria: * female * age 60 years or older * have urinary incontinence * not currently meeting national recommendations for physical activity (150 minutes of weekly moderate intensity aerobic exercise and twice weekly strength building exercise. * at risk for functional decline per the vulnerable elders survey (score of 3+) * free of dementia (pass mini-cog screening) exclusion criteria: * cognitive impairment * grade 4 vaginal prolapse or pessary use * orthopedic surgery in past year * urinary retention (catheter use) * neurological cause for urinary incontinence (i.e. parkinson's disease, ms) * bladder cancer * bladder or incontinence surgery in past year * recipient of hospice or palliative care * ostomy * new prescription or dosage change in past three months for anti-incontinence medication

Keywords: toileting disability functional urinary incontinence urinary incontinence frailty physical activity
drug combination on exercise performance at high altitude

Conditions: Acute Mountain Sickness

Summary: this study is being conducted to determine the effectiveness of using two fda approved medications in concert to reduce the likelihood of sickness due to low oxygen levels and to reduce the decrement in physical performance at higher elevations. the investigators hypothesize that this drug combination will reduce the symptoms of acute mountain sickness and improve exercise performance at high altitude compared to placebo.


Eligibility criteria:
inclusion criteria: * healthy males exclusion criteria: * vo2max below 45ml/kg/min * currently taking any medication

Keywords: exercise performance