Kornimate/medical-research-clean huggingface dataset:
testing an hiv prevention intervention for psychiatric patients in brazil

Conditions: HIV Infection; HIV Infections

Summary: this study will test the effectiveness of a program aimed at reducing behaviors that increase hiv risk among people with severe mental illnesses.

hiv is a virus that weakens a person's immune system and can cause aids. it is most commonly transmitted through unprotected sexual contact. people with a mental illness who are sexually active may be at risk of hiv infection, but most interventions for reducing risk of hiv infection do not target this particular population. this study will test an intervention aimed at reducing behaviors with a high risk of causing hiv infection in sexually active people with a mental illness. participation in this study will last 15 months. at study entry, participants will complete a baseline interview with a research assistant. this interview will evaluate sexual activity, knowledge of hiv, the participant's psychiatric diagnosis and symptoms, attitude toward condoms, and stigma related to mental illness experienced by the participant. participants will then be randomly assigned to either an hiv risk reduction group or a general health group. both of these groups will meet once a week for 8 weeks. those in the hiv risk reduction group will learn information and take part in activities aimed at reducing behaviors that place people at a high risk of being infected with hiv. those in the general health group will learn about long-term serious medical conditions, such as diabetes and high blood pressure, that may be common in people with a mental illness. participants will complete two follow-up visits after their 8-week intervention, one the week after and one 3 months after. participants will then complete a "booster" of three weekly group sessions covering the same information from their 8-week intervention. more follow-up visits will occur 1 week and 6 months after participants complete the booster sessions. all follow-up visits will involve an interview similar to the one held at study entry. additionally, feedback forms will be completed at the first interview at study entry, after the eight group sessions, after the three booster sessions, and at the last interview.

Eligibility criteria:
inclusion criteria: * being treated as a patient in one of the study psychiatric clinics * sexually active in the past 3 months exclusion criteria: * primary alcohol or other drug use disorder * acutely psychotic or actively suicidal at the time of the screening interview * developmental disability as a primary diagnosis * unable to speak portuguese

Keywords: hiv information hiv prevention severe mental illness hiv seronegativity
safety and efficacy study of copaxone administered in combination with n-acetylcysteine

Conditions: Relapse Remitting Multiple Sclerosis

Summary: this study evaluates the effect of the therapy combining ga and nac on disease activity as reflected by mri parameters while assessing tolerability and safety.


Eligibility criteria:
inclusion criteria: 1. clinically definite multiple sclerosis (cdms) as defined by poser et al (ann neurol 1983). 2. subjects must have at least one t1 gd-enhancing lesion in one of the pre-treatment mri scans. 3. subjects must have a relapsing-remitting disease course. 4. subjects must have had at least one documented relapse within the last year prior to the screening visit (week -10). 5. subjects must be relapse-free and not have taken corticosteroids (iv, im and/or po) within the 30 days prior to the screening visit. 6. subjects may be male or female. women of child- bearing potential must practice a medically acceptable method of birth control. acceptable methods include oral contraceptive or double-barrier method (condom or iud with spermicide). 7. subjects must be between the ages of 18 and 50 years inclusive. 8. subjects must be ambulatory, with a kurtzke edss score of between 0 and 5.0 inclusive. 9. subjects must be willing and able to give written informed consent prior to entering the study. exclusion criteria: 1. previous use of injected glatiramer acetate. 2. previous use of cladribine within 2 years prior to screening visit (week -10). 3. previous use of immunosuppressive agents in the last 6 months. 4. use of experimental or investigational drugs, including i.v. immunoglobulin, within 6 months prior to study entry. 5. use of interferon agents within 60 days prior to the screening visit. 6. chronic corticosteroid (iv, im and/or po) treatment (more than 30 consecutive days) in the 6 months prior to study entry. 7. chronic use of antioxidant substance(s), including nac, (more than 30 consecutive days) within 60 days prior to the screening visit. 8. previous total body irradiation or total lymphoid irradiation (tli). 9. pregnancy or breastfeeding. 10. significant medical or psychiatric condition that affects the subject's ability to give informed consent, or to complete the study, or any condition which the investigator feels may interfere with participation in the study (e.g. alcohol or drug abuse). 11. a known history of uncontrolled asthma. 12. a known history of sensitivity to mannitol or acetylcysteine. 13. inability to successfully undergo mri scanning.
hiv-infected latin american asylum seekers in europe: insights from the eurolatin hiv cohort

Conditions: HIV-1-infection; Sexually Transmitted Diseases

Summary: this is a longitudinal observational study conducted in europe that describes migrants infected with hiv from latin america who come to europe with the intention of seeking asylum or international protection. the aim of the study is to identify the barriers this population faces in accessing the healthcare system and to assess disease control

study design and setting this observational study was conducted between 2022 and 2023 in madrid, spain. participants were recruited at the hiv outpatient clinic of infanta leonor university hospital (huil) for the study and were monitored for a period of 6 months from their enrollment in the study. participant recruitment participants were primarily identified and referred by various non-governmental organizations (ngos) working with migrants living with hiv. these ngos, which included gtt-vih, apoyo positivo, cogam, acción triangulo, kif-kif, salud entre culturas, and the spanish red cross, played an essential role by establishing a crucial link and provided a vital bridge, facilitating the patients' integration into the healthcare system through an unconventional circuit. medical evaluation in the hiv unit, assessments were conducted by experienced infectious disease specialists and a unit-specific nurse. the care protocol comprised a meticulous collection of medical history, an exhaustive physical examination, along with a series of tests. furthermore, appointments were scheduled for a one-month and six-month follow-up to ensure continuous care and monitor the effectiveness of the treatment regimen. social and psychological evaluation an experienced social worker with a background in vulnerable populations was hired to perform a social assessment. six months post the initial hospital visit, the social worker re-established contact with the patients to reassess their social circumstances and their continued engagement with the hiv consultation services. ethical considerations this study adhered to the ethical principles outlined in the declaration of helsinki and received the necessary approvals from the ethics committee at infanta leonor hospital. informed consent was provided by every participant. data collection in this study, the redcap application was utilized for the collection of data. the database was stored in a secure server, and only researchers and health personnel of the project had access to it.

Eligibility criteria:
inclusion criteria: * latin american migrants infected with hiv who arrive in spain with the intent to seek international protection and who lack access to healthcare. exclusion criteria: * those who do not give their consent

Keywords: asylum seekers migration europe latin america
telephone reminder to increase appointment rates

Conditions: Reminder Systems; Substance-Related Disorders

Summary: missed appointments to outpatient substance use treatment are common and costly and can have a negative effect on the health of patients. in this quasi-experimental study, the investigators used an on-off design to examine whether a reminder "plus" intervention (telephone call from therapist before first appointment) would increase attendance and improve cancellation and rebooking practices. secondary outcomes included satisfaction with treatment and intention to complete the treatment program.


Eligibility criteria:
inclusion criteria: * newly referred patient * \> 18 years * diagnosis: substance related disorder exclusion criteria: * patients who are unable to understand or score the survey due to cognitive or language barriers
safety study of xl765 (sar245409) in combination with erlotinib in adults with solid tumors

Conditions: Cancer; Non-Small Cell Lung Cancer

Summary: the purpose of this study is to evaluate the safety and tolerability of xl765 in combination with erlotinib (tarceva®) in subjects with solid tumors. xl765 is a new chemical entity that inhibits the kinases pi3k and mtor. in preclinical studies, inactivation of pi3k has been shown to inhibit growth and induce apoptosis (programmed cell death) in tumor cells, whereas inactivation of mtor has been shown to inhibit the growth of tumor cells. erlotinib is an orally administered inhibitor of egfr (also known as her1) tyrosine kinase. it was approved by the fda as a single agent for the treatment of patients with locally advanced or metastatic non-small-cell lung cancer (nsclc) after failure of at least one prior chemotherapy regimen and in combination with gemcitabine for first line treatment of patients with locally advanced, unresectable or metastatic pancreatic cancer.


Eligibility criteria:
inclusion criteria: * confirmed diagnosis of: * advanced solid tumor that is no longer responding to therapies or * advanced or metastatic nsclc that has previously been treated with erlotinib or gefitinib * ecog performance status 0-1 * adequate organ and bone arrow function as defined by hematological and serum chemistry limits * at least 18 years old * both men and women must practice adequate contraception * informed consent exclusion criteria: * restriction of some therapies/medications within specific timeframes prior to enrollment and during the study including prior therapy with pi3k, cytotoxic chemotherapy, biologic agents, nitrosoureas or mitomycin c, small-molecule kinase inhibitors, non-cytotoxic hormonal agents * erlotinib intolerant * taking oral corticosteroids chronically or \> 1 mg/day warfarin * not recovered from the toxic effects of prior therapy * history of diabetes mellitus and an hgba1c \> 7% * uncontrolled intercurrent illness * pregnant or breastfeeding * congestive heart failure, unstable angina, or a myocardial infarction within 3 months of entering the study. * hiv positive * diagnosis of another malignancy may exclude subject from study

Keywords: cancer solid tumors nsclc
a non-interventional retrospective study of the current treatment practice in european haemophilia care

Conditions: Haemophilia A; Haemophilia B

Summary: to describe the current treatment practice during 12 months for previously treated patients diagnosed with haemophilia a or haemophilia b.

the study population consists of patients with a diagnosis of icd10: haemophilia a d66.9 or haemophilia b d67.9.

Eligibility criteria:
inclusion criteria: * male patients with severe or moderate haemophilia a or haemophilia b. * treatment with factor viii/factor ix products initiated at least 24 months before inclusion in the study. * informed consent is obtained from the patient or patient's legal representative (as applicable according to legal regulation). exclusion criteria: * confirmed positive inhibitor test detected in the past 24 months.
fertility preservation for transfeminine adolescents via semen cryopreservation or testicular sperm extraction

Conditions: Gender Dysphoria, Adolescent

Summary: the goal of this observational cohort study is to identify and predict parameters for successful testicular sperm extraction (tese) procedures or semen cryopreservation more accurately and to evaluate the decision making process and the experience of postponing or temporarily discontinuing puberty suppression to undergo successful fertility preservation. in transfeminine (assigned male at birth) adolescents. the main question\[s\] it aims to answer are: * what is the optimal timing for fertility preservation before the start or after temporarily discontinuing puberty suppression puberty suppression * how do transfeminine adolescents and their parents experience the decision making process of fertility preservation * how do transfeminine adolescents and their parents experienced postponing or temporarily discontinuing puberty suppression to undergo successful fertility preservation? participants will be asked to use their medical data, answer a questionnaire or participate in a (online) interview.


Eligibility criteria:
inclusion criteria: * before start of puberty suppresion with a wish for fertility preservation * after discontinuing puberty suppersion before the start of hormone therapy exclusion criteria: * tanner stage \> 4/5

Keywords: testicular sperm extraction fertility preservation puberty suppresion
tipranavir expanded access program (eap) in pi-experienced patients with hiv-1 infection

Conditions: HIV Infections

Summary: this study was designed to provide early access to and evaluate the safety of tpv/r in pi-experienced patients with hiv-1 infection.


Eligibility criteria:
combustion derived air pollution and vascular function

Conditions: Endothelial Dysfunction

Summary: air pollution is a major cause of cardiovascular morbidity and mortality. the components of air pollution responsible and the mechanisms through which they might mediate these harmful effects remain only partially understood. the link between cardiovascular disease and air pollution is strongest for fine particulate matter. fine particulate matter (pm) is produced from the combustion of fossil fuels with the most significant threat thought to be posed by small particles less than 10µm (pm 10) which can be inhaled into the lungs. we propose to identify the precise component of diesel exhaust that mediates the adverse cardiovascular effects using a carbon particle generator, and a particle concentrator. the aim of this study proposal is to assess the vascular effects of different types and components of air pollution in healthy subjects. we intend to test the hypotheses that: 1. combustion derived nanoparticulate causes an acute impairment of endothelial vasomotor and fibrinolytic function in healthy volunteers. 2. exposure to combustion derived air pollution is associated with increased thrombus formation.


Eligibility criteria:
inclusion criteria: * healthy volunteers exclusion criteria: * current smokers * significant occupational exposure to air pollution * history of lung disease * women of child-bearing potential * malignant arrhythmias * renal or hepatic failure * significant co-morbidity * systolic blood pressure \>190 or \<100 mmhg * previous history of blood dyscrasia * unable to tolerate the supine position * lack of informed consent * blood donation within last 3 months

Keywords: air pollution particles particulate matter vascular function endothelial function thrombosis
a healthcare economic study of the click sexual health test

Conditions: Sexually Transmitted Diseases

Summary: this is a multicenter study with a minimum of three clia-waived intended operator sites in which prospectively collected vaginal swab specimens will be evaluated with the click sexual health test as compared to standard of care. the specimen collection will occur over one study visit for each enrolled subject, but study staff will continue to follow the subject through standard of care until the subject receives treatment or she is lost to follow up.


Eligibility criteria:
inclusion criteria: * documentation that the subject has provided informed consent prior to conducting study procedures * subject is symptomatic or asymptomatic for sexually transmitted infections * subject is female and 14 years of age or older at the time of enrollment * able and willing to follow study procedures exclusion criteria: * subject has been previously enrolled in the study * subject has a contraindication, medical condition, serious intercurrent illness or other circumstance that in the investigator's judgement, could jeopordize the subject's safety or could interfere with the study procedures * use of antiperspirants and deodorants or the following vaginal products: douches, washes, lubricants, vaginal wipes, vaginal moisturizers, or feminine hygiene spray in the genital area, within 48 hours prior to enrollment.
endoscopic submucosal dissection combine with laparoscopic regional lymph node dissection for early gastric cancer

Conditions: Early Gastric Cancer

Summary: the purpose of this study is to determine whether endoscopic submucosal dissection combine with laparoscopic regional lymph node dissection for early gastric cancer can improve disease-free survival ？

patients with early stage of gastric cancer(t1a/t1bn0m0,nccn2014.v1) will depart into two group randomized double-blind, then experimental group accept endoscopic submucosal dissection combine with laparoscopic regional lymph node dissection ,and control group accept endoscopic submucosal dissection only.the follow-up time is from operation to recrudescence.

Eligibility criteria:
inclusion criteria: * ct1a：ulcer（+）and lesion diameter\>3cm and differentiated type. any ulcer and lesion diameter d\>2cm and poorly differentiated type. * ct1b: submucosal injection (+) exclusion criteria: * metastasis * recrudescence

Keywords: endoscopic submucosal dissection laparoscopic regional lymph node dissection early gastric cancer disease-free survival
mandibular advancement bite block efficacy observational study

Conditions: Airway Obstruction

Summary: the purpose of this study is to compare the effect of mandibular advancement bite block to standard bite block for prevention of hypoxemia, intervention events and adverse effects during endoscopic examinations.

during endoscopic examinations, especially upper gastrointestinal, bile duct, or bronchoscopic examinations, the endoscope need to be placed through the mouth. a bite block is used to protect vulnerable endoscope and protect patient's teeth. during sedative endoscopic exams, respiratory depression, apnea or upper airway obstruction will occur under the influence of the sedative medications. serious adverse events may occur such as hypoxemia. a nasal airway, larson's maneuver, jaw thrust or chin lift may be needed to open airways. mandibular advancement devices has been widely used in treating obstructive sleep apnea. a modified bite block that provides mandibular advancement could provide entry inlet of endoscope as well as provide mandibular advancement to provide patent airway during sedative endoscopy. in this study, we group the patients into test group using mandibular advancement bite block and a control group using standard bite block. after anesthetic induction, gastric endoscopy was performed. degree of upper airway obstruction will be evaluated and recorded. differences between the two groups will be evaluated.

Eligibility criteria:
inclusion criteria: * american society of anesthesiologist class i or ii * patients undergoing routine upper gastrointestinal endoscopy under sedation exclusion criteria: * baseline oxygen saturation \< 90% * known difficult airway * oral or facial surgery history * bmi \> 35 * patients with gastroparesis or gastrointestinal bleeding * anticipated exam time \> 30 minutes

Keywords: gastrointestinal endoscopy moderate sedation airway management
effects of a nutritional supplementation on the functional status of frail elders with low socioeconomic status (ses)

Conditions: Frail

Summary: the purpose of this study is to determine whether protein-energy nutritional supplementation improves geriatric function in community-dwelling frail older adults of low socioeconomic status.

chronic undernutrition is a common condition in older people, and is clearly an important component of frailty. however, the effect of protein-energy nutritional supplementation on the functional status of frail older people is controversial. some investigators suggested that, if nutritional or functional status has deteriorated too far, it could be very difficult for single nutritional supplementation to reverse malnutrition progression or functional decline. the investigators believe one of the reasons for these ineffective results, especially for the community-dwelling frail elderly, may be due to a lack of regard to the socioeconomic status of the study population. for this reason, the investigators recruited a study sample with low socioeconomic status and evaluated the effect of protein-energy nutritional supplementation on their disability scores and physical performance.

Eligibility criteria:
inclusion criteria: * older adults over 65 years of age, registered in the national home healthcare service database * require more than 5 seconds to perform 3m walking test (usual gait speed \<0.6 m/sec) * get less than 24 points on mini nutritional assessment (mini nutritional assessment \<24) exclusion criteria: * unable to walk or are too functionally deteriorated to receive home health care services * who were participating in any kind of exercise program or clinical nutrition program * who were restricted to a high-protein diet by an internist (i.e., for liver failure or severe renal failure)

Keywords: frailty, nutritional supplementation, functional status