Kornimate/medical-research-clean huggingface dataset:
lingual muscle training in late-onset pompe disease (lopd)

Conditions: Glycogen Storage Disease

Summary: this study is being done to test the effects of lingual muscle therapy (lmt) in patients with late-onset pompe disease (lopd) who have tongue weakness. the results of this study will help design future research studies about lmt in lopd.


Eligibility criteria:
inclusion criteria: * age ≥ 12 years * lingual weakness as measured by quantitative muscle testing (≤ 5% lower limit of normal for stratified age) * confirmed diagnosis of lopd * on enzyme replacement therapy for ≥ 26 weeks at pretest * able to follow directions for study participation * able to complete a home-based lmt regimen * access to reliable internet connection * access to use of electronic device that allows for facetime, jabber, or webex use exclusion criteria: * neurodegenerative conditions (e.g. stroke, dementia) or other serious neurologic condition that would prevent meaningful study participation as determined at the discretion of the principle investigator * any current or past history of seizures. * head and neck cancer or radiation treatment to head/neck * inability to tolerate iopi device tongue bulb * inability to give legally effective consent * inability to read and understand english
yoga, education, and nidra (yen) for chronic low back pain: a pilot study on pain modulation, well-being, and sleep

Conditions: Low Back Pain

Summary: the purpose of this study is to compare the impact of yoga, pain education, and yoga nidra with pain acceptance intention to yoga, pain education, and relaxing music on pain intensity, well-being, and sleep quality. this is a pilot study trial of individuals with chronic low back pain. participants will attend two sessions in the laboratory (week 1 and week 8) and complete their assigned intervention 2 x per week for 6 weeks at home. participants will be randomized to either receive yoga postures targeting the low back, pain education, and yoga nidra with pain acceptance intention and motor imagery or yoga postures targeting the low back, pain education, and relaxing music.


Eligibility criteria:
inclusion criteria: * chronic pain in lower back that has lasted for over three months * pain intensity rated as 3/10 or higher in the past 24 hours (0=no pain, 10=worst pain imaginable) exclusion criteria: * non-english speaking * systemic medical conditions that affect sensation (such as uncontrolled diabetes) * history of surgery or fracture within the past six months * any blood clotting disorders (such as hemophilia) * any contraindication to the application of ice (blood pressure \> 140/90 mmhg, cold urticaria, cryoglobulinemia, paroxysmal cold hemoglobinuria, circulatory compromise) * exceed pressure and heat sensory thresholds * unable to access the internet or email * pregnant * unable to exercise without medical clearance (assessed on par-q+ on first visit)
effectiveness of rotation-advancement and straight-line surgical approaches in repairing unilateral cleft lip defect

Conditions: Unilateral Cleft Lip

Summary: compare different effects of rotation-advancement based on the millard technique and straight-line based on fisher modification as surgical approaches in repairing lip defect of unilateral cleft lip patients.

twelve participants with unilateral cleft lip equally divided into two groups. both groups were photographed preoperative and postoperative. the control group treated using (rotation-advancement) based on the millard technique; and the test group treated using (straight-line) technique based on fisher modification.

Eligibility criteria:
inclusion criteria: * have complete unilateral cleft lip * from birth to 4 years old exclusion criteria: * syndromic cleft patient
perioperative modification of hemostasis during ventricular assist device implantation

Conditions: End-stage Heart Failure

Summary: implanting a ventricular assist device (vad) is a promising therapy for end-stage cardiac failure. however, the implantation of these devices is associated with a high risk of severe hemorrhages and massive blood product transfusion in the first 48 hours following the implantation. the primary purpose of this study is to assess the functionality of the von willebrand factor (vwf) which is essential for hemostasis. the hypothesis is that the high shear stress generated by these vad expose adamts13 cleaving site on the vwf. this result in a loss of high molecular weight vwf and an acquired von willebrand syndrome. the secondary purpose of the protocol is to assess platelet function after the implantation of vad. indeed, platelet function might be affected shortly after the implantation of the device.


Eligibility criteria:
inclusion criteria: * age over 18 years old * who gave his consent to the study * with an end-stage heart-failure * under surgery for a ventricular assist device implantation * scheduled or in emergency exclusion criteria: * preoperative anemia less than 7 g/dl * subject under the protection of justice * subject under guardianship or curatorship * pregnancy * breastfeeding
study to evaluate the safety and immunogenicity of a multivalent pneumococcal vaccine given with prevnar 13 in healthy infants

Conditions: Pneumococcal Infections

Summary: this is a phase 2, randomized, active-controlled, open-label study with a 3-arm parallel design. healthy 2-month old infants (42 to 98 days of age) with no history of pneumococcal vaccination will be randomized in a 1:1:1 ratio to receive a 4-dose series of: multivalent pneumococcal conjugate vaccine coadministered with prevnar 13 (group 1); multivalent pneumococcal conjugate vaccine given 1 month after prevnar 13 (group 2); or prevnar 13 with a single dose of multivalent pneumococcal conjugate vaccine (group 3).


Eligibility criteria:
inclusion criteria: * male or female infant born at \>36 weeks of gestation and aged 2 months (42 to 98 days) at the time of consent (the day of birth is considered day of life 1). * healthy infant determined by medical history, physical examination, and clinical judgment. exclusion criteria: * previous vaccination with licensed or investigational pneumococcal vaccine. * prior receipt of routine pediatric vaccines, with the exception of hepatitis b vaccine. * previous receipt of \>1 dose of hepatitis b vaccine. * prior hepatitis b vaccine must have been administered at age \<30 days. * major known congenital malformation or serious chronic disorder. * receipt of blood/plasma products or immunoglobulins.
predicting oxygen desaturation in chronic obstructive pulmonary disease (copd) patients

Conditions: COPD

Summary: oxygen desaturation (so2 \< 88-90%) during walking is a common clinical feature of chronic obstructive pulmonary disease (copd) patients. by a predicted analysis our study is aimed to evaluate anthropometric and functional characteristics of copd patients correlated with oxygen desaturation during six-minute walking test (6mwt).


Eligibility criteria:
inclusion criteria: * copd patients * ability to perform 6mwt * normal oxygen saturation at rest and at the begin of 6mwt exclusion criteria: * no-copd patients * chronic respiratory failure patients in long-term oxygen therapy (ltot) * any co-morbidities

Keywords: copd oxygen desaturation walking test
three-dimensional lumbar myofascial release and motor control in lumbar radiculopathy

Conditions: Lumbar Radiculopathy

Summary: to investigate the efficacy of three-dimensional lumbar myofascial release with motor control training on back perception and pain in lumbar radiculopathy patients with lumbar radiculopathy demonstrate impairments in function and range of motion to deficits in patient's quality of life.

purpose: to investigate the efficacy of three-dimensional lumbar myofascial release with motor control training on back perception and pain in lumbar radiculopathy patients with lumbar radiculopathy demonstrate impairments in function and range of motion to deficits in patient's quality of life. hypotheses: it will be hypothesized that there will be no statically effect of three dimensional lumbar myofascial release with motor control training on back perception and pain in lumbar radiculopathy research question: is there an effect of three-dimensional lumbar myofascial release with motor control training on back perception and pain in lumbar radiculopathy

Eligibility criteria:
inclusion criteria: * their ages range from 35 to 50 years. * both sex * unilateral lumbar radiculopathy for more than 6 months. * normal body mass index (18.5 - 24.99kg/m2). exclusion criteria: * • any other musculoskeletal disorders of the spine or upper extremity * patients with any other neurological deficits, psychiatric disease lumbar myelopathy, cognitive problems, vertebral fractures and previous history of spine or lumbar surgery. * clinical instability, recent trauma * structural abnormalities of the spine, osteoporosis, and spasmodic torticollis. * inflammatory or other specific disorders of spina such as ankylosing spondylitis and rheumatoid arthritis
effect of sodium bicarbonate buffered lidocaine on the success of ian block of teeth with irreversible pulpitis

Conditions: Local Anesthesia

Summary: buffering of local anesthetics (alkalinization) has been suggested in achieving pain control. the purpose of this prospective, randomized, double-blind study was to evaluate the effect of adding 0.6 ml 8.4% sodium bicarbonate to 3.0 ml 2% lidocaine with 1: 80,000 epinephrine on the success rate of ian block for endodontic treatment of mandibular molars with symptomatic irreversible pulpitis.

some studies have been shown buffering of local anesthetics reduce pain of injection, hasten the onset of anesthesia, and improved success rate of anesthesia. others reported buffering of local anesthetics cannot reduce pain of injection, hasten the onset of anesthesia, and improve success rate of anesthesia. there are no studies evaluating a sodium bicarbonate-buffered lidocaine formulation for ian block for teeth with irreversible pulpitis.

Eligibility criteria:
inclusion criteria: * vital mandibular molar tooth * diagnosis of symptomatic irreversible pulpitis exclusion criteria: * younger than 18 years old * history of significant medical conditions * allergies to local anesthetics or sulfites * pregnancy * taking any medications that might influence anesthetic assessment * active sites of pathosis in area of injection * inability to give informed consent

Keywords: buffered inferior alveolar nerve block irreversible pulpitis local anesthesia sodium bicarbonate
telemedicine for patients suffering from heart failure (danish telecare north trial)

Conditions: Heart Failure

Summary: there are two main aims in this study. the first objective is to evaluate whether a particular telehealth solution, in addition to standard treatment and care, lead to a significant decrease in the mortality and an increase in health related quality of life for patients suffering from heart failure that may benefit from telehealth compared with only standard treatment and care. the second objective is to examine the additional costs of the telehealth solution and assess whether this solution is a cost-effective way to care for patients with heart failure across patients and municipality districts. it is hypothesized that telehealth care will increase patients quality adjusted life years compared to usual practice, since no difference in mortality and a higher health related quality of life is expected. furthermore, it is hoped that there will be a 30% reduction in the number of admissions and readmissions to hospitals and a 30% reduction in the number of outpatient visits resulting in fewer costs for hospitals. however, it is uncertain as to whether these savings are offset by other costs such as more visits to general practitioners, community care or the implementation costs.


Eligibility criteria:
inclusion criteria: * all heart failure patients that may benefit from telehealthcare. * participants are qualified for inclusion if they have been diagnosed with hf according to national guidelines and are nyha classified 2,3, and 4. * patients must have a permanent residence and be motivated for using telehealthcare. \*patients must have a landline or mobile phone and be able to speak danish or they must live with a relative speaking danish. such that the relative must be able to help the patient in translating the information in the use of telehealthcare. exclusion criteria: * patients without landline phone / mobile phone or gsm (global system for mobile communications) coverage. * patients not able to understand danish adequately to complete the questionnaires in the study or patients having a cognitive impairment. * comorbidity is not an exclusion criterion.

Keywords: telemedicine effectiveness cost-effectiveness
fes-rowing: preventing the secondary conditions of paralysis through vigorous exercise

Conditions: Paralysis, Legs

Summary: over the past ten years, the cardiovascular research laboratory at spaulding has refined a unique form of exercise for those with spinal cord injuries (sci). functional electrical stimulation row training (fesrt) couples volitional arm and electrically controlled leg exercise, resulting in the benefits of large muscle mass exercise. despite the success of the fes-rowing program at spaulding, fes-rowing systems have not yet evolved beyond research prototypes, and ours is the only program in the us where fes-rowing is available. a new design is critically needed to enable people with paralysis to participate in fes rowing in their own homes, which we believe will maximize both the health and commercial impacts of fes-rowing.

the purpose of this observational study is to gain insights into user needs, and market perception of physical activity and fes-rowing to further develop a new, home-based fes-rowing system that meets the needs of people with paralysis. we will enroll a total of 20 subjects, male and female, 18 years and older with lower-limb paralysis who use a wheelchair as their primary means of mobility. ten subjects will be current fes-rowing participants (especially those doing fes-rowing at home) and 10 subjects will be non-participants. to determine user needs we will survey prospective customers to discover their motivations, preferences and challenges pertaining to participation in physical activity in general and fes-rowing. questionnaires: barriers to physical activity questionnaire for people with mobility impairments (bpaq-mi): measures barriers to physical activity across the intrapersonal and interpersonal domains. physical activity and disability survey (pads): measures physical activity for people with chronic neurological conditions. demographic and mobility questionnaire: important information to inform on user and design needs and potential market for at home fes-row system. quebec user evaluation of satisfaction with assistive technology (quest 2.0)-(fes-row participants only): measures satisfaction with current fes-row system used in the expd program.

Eligibility criteria:
* male and female, * 18 years of age and older * lower-limb paralysis who use a wheelchair as their primary means of mobility. exclusion criteria: * under 18 years of age * no lower-limb paralysis * people who do not use a wheelchair as their primary means of mobility
respiration in chronic low back pain

Conditions: Chronic Low-back Pain

Summary: the goal of this observational study is to learn about respiratory muscle strength, respiratory functions, and balance in patients with chronic low back pain.

coordination between the stabilizer muscles of the trunk and respiratory functions may be lacking in people with chronic low back pain. however, a specially designed study investigating the relationship between respiratory functions and balance parameters in individuals with chronic low back pain is lacking. the goal of this observational study is to learn about respiratory muscle strength, respiratory functions, and balance in patients with chronic low back pain. twenty-four individuals with low back pain for at least 6 months are going to include in the study. pain assessment is going to assess with a visual analogue scale. respiratory muscle strength is going to measure by maximal inspiratory pressure (mip) and maximal expiratory pressure (mep). pulmonary function assessment (pft) is going to assess using a spirometer. balance assessment is going to evaluate with star balance test and berg balance scale. flexibility is going to evaluate with the functional reach test.

Eligibility criteria:
inclusion criteria: * being diagnosed with chronic low back pain * being age 25-65 * defining pain with a minimum of 5 out of 10 in visual analog scale (vas) * getting at least 24 points from the mini mental test. exclusion criteria: * having physical therapy in the last one month * orthopedic, neurological, and vestibular problems that will affect balance * severe discopathy * compression fracture * pregnancy * body mass index (bmi) of \> 30kg

Keywords: respiratory muscles respiratory function test muscle strength
difference in pain perception by patients with prostate biopsy using instillagel compared with guided ultrasound gel

Conditions: Prostate Biopsy

Summary: this is a randomized controlled trial. one group (intervention group) will get in advance to the prostate biopsy rectal approximately 5 cc instillagel. and one group (control group) will get in advance to the ultrasound -guided prostate biopsy rectal gel. pain is measured using the numerical rating scale (nrs). the nrs is an imaginary line from 0 until 10. the 0 is no pain and 10 is most worst imaginable pain.

urologist within rijnstate use both instillagel and ultrasound gel during prostate biopsy. according to the protocol, the ultrasound-guided prostate biopsy must be performed using ultrasound gel. some urologists departed from the protocols because they think that instillagel will give a pain reduction. with this research we investigate whether instillagel will have an effect on the pain perception bij the patients. there will be three moments of pain measurements; prior to het prostate biopsy. immediately after the prostate biopsy. and five to thirty minutes after the prostate biopsy, when the patient is dressed and before the patient goes home. primary endpoint pain measured by the numeric rating scale secondary endpoints * age of patient * previous prostate biopsy * the number of biopsies taken * presence of prostate cancer * other complications as after prostate biopsy the prostate biopsy will be performed by a urologist working at the outpatient clinic of rijnstate. the ultrasound equipment that will be used during prostate biopsy is aloka prosound ssd-3500 or aloka prosound ssd or sv-3500 sx.

Eligibility criteria:
inclusion criteria: * outpatient ultrasound guide prostate biopsy * \> 40 years old. * good knowledge of dutch language exclusion criteria: * coagulation disorders * disorders of the rectum like hemorrhoids, anal fistula, proctitis, rectal polyps and rectal cancer. * treated for active urinary tract infection * known of allergy to lidocaine * taking antidepressants * using anaesthetic agents * neurological disorders such as parkinsons disease, hernias and spinal cord injury * treated with radiotherapy for prostate cancer

Keywords: prostate biopsy nrs-score instillagel ultrasound conductive gel
efficacy of a full-thickness placental allograft in lumbar microdiscectomy

Conditions: Surgical Wound; Herniation

Summary: to evaluate the efficacy of full thickness placental allograft use in microdiscectomy application. to evaluate post-microdiscectomy reherniation rate in patients treated with full-thickness placental allografts.

the primary objective is to evaluate the efficacy of full thickness placental allograft use in improving back and leg pain, when applied to patients undergoing lumbar microdiscectomy.

Eligibility criteria:
inclusion criteria: * ambulatory with radiating low back and leg pain for greater than 6 months prior to surgery with clinical diagnosis of lumbar protruding disc. * consent and compliance with all aspects of the study protocol, methods, providing data during follow-up contact. exclusion criteria: * severe hypertension systolic blood pressure (greater than or equal to 200 mm -hg or diastolic blood pressure greater than or equal to 182 mm hg) * bmi greater than 45 kg/m2 * subject has had major surgery at the index level * is an active smoker or stopped smoking in the last 6 months * any pain that could interfere with the assessment of index level pain (e.g. pain in any other part of the spine) * active rheumatoid arthritis * active, local or systemic malignancy such as lung cancer or leukemia * history of vascular disease or sickle cell anemia * use of the following medications: no significant anticoagulant therapy (e.g. heparin or lovenox) during the study (treatment such as aspirin and plavix are allowed) * no systemic treatments that may interfere with safety or efficacy assessments during the study * no immunosuppressants * no use of corticosteroids * subject is pregnant or plans to become pregnant within 24 months of treatment * subject does not provide full consent * personal injury, workman's compensation or other legally-related treatment patients.