study on the mechanism of prevotella copri promoting the occurrence and development of atherosclerosis

Conditions: Atherosclerosis

Summary: mainly studying the correlation between the abundance of prevotella copri （p.copri） in the gut microbiome and the progression of clinical coronary atherosclerotic heart disease（cad） patients, and confirming that an increase in p.copri abundance will accelerate the occurrence and development of cad disease, accompanied by an increase in serum branched chain amino acid（bcaa）, lipopolysaccharide（lps）, and serotonin; for people who mainly consume a high carbon water diet, blood sugar is a stronger risk factor for as compared to blood lipids; explore the kap status（study composes of knowledge, attitude, and practice） of coronary heart disease patients and their caregivers regarding coronary heart disease and diet, and investigate whether the popularization of science after kap investigation can change the treatment effect of patients.

confirming the progression of coronary heart disease in patients and the proportion of p.copri in the gut microbiome; confirming that due to the increased abundance of p.copri, factors related to blood glucose metabolism disorders are more associated with the progression of cad disease compared to lipid factors; confirming that p.copri induces insulin resistance and inflammation in the body while altering intestinal permeability through the synthesis of bcaa, lps, and serotonin;; through controlled experiments conducted at our center, investigators effectively popularized disease science to patients and their caregivers, promoted their participation in disease treatment, and confirmed that the kap survey method can optimize patient treatment effectiveness, improve doctor-patient relationships, and enhance patient hospitalization experience. through this research project, investigators explore the application of kap research in the form of a questionnaire in this discipline. through kap research, investigators aim to popularize knowledge about dietary patterns and coronary heart disease among multi center coronary heart disease patients and their caregivers. investigators also investigate the "knowledge", "belief", and "behavior" of current coronary heart disease patients and their caregivers regarding coronary heart disease diagnosis and treatment knowledge, and conduct a knowledge lecture, establish a new model for mastering, attitudes, and actions related to the diagnosis and treatment of coronary heart disease among patients and their accompanying caregivers through data push and other forms, while also providing theoretical and practical basis for subsequent related research. through this project, investigators will discuss the feasibility of kap survey in increasing patients' subjective initiative, improving doctor-patient relationships, and promoting the effectiveness of patient treatment. investigators will also discuss its promotion and inclusion in routine diagnostic and treatment methods.

Eligibility criteria:
inclusion criteria: 1. atherosclerosis mechanism research: diagnosis is made through clinical diagnostic technical indicators, mainly coronary ct or coronary angiography. experimental group: patients with coronary heart disease are identified; control group: admitted patients without coronary heart disease but may have other heart diseases or risk factors; age:\>50 years old 2. kap study: coronary heart disease patients and their families exclusion criteria: 1. atherosclerosis mechanism research: age\ 2mg/dl (176.8 μ mol/dl), collagen diseases, etc; patients who have been using antibiotics within the past 6 months; patients with malignant tumor disease 2. kap study: non coronary heart disease patients and their caregivers