Kornimate/medical-research-clean huggingface dataset:
characterization of bam8-22 as a new surrogate model of non-histaminergic itch

Conditions: Itch

Summary: with this experiment, the experimenter wish to asses if substance bam8-22 (bovine adrenal medulla) induce non-histaminergic itch.

with this experiment, the experimenter wish to establish if the substance bam8-22 (bovine adrenal medulla) induce a non-histaminergic itch by using the antihistamine doxepin. the experimenter will also compare itch and the response to antihistamine of bam8-22, histamine and cowhage.

Eligibility criteria:
inclusion criteria: * healthy men and women * 18-60 years * speak and understand english exclusion criteria: * pregnancy or lactation * drug addiction defined as any use of cannabis, opioids or other drugs * previous or current history of neurological, dermatological, immunological musculoskeletal, cardiac disorder or mental illnesses that may affect the results (e.g. neuropathy, muscular pain in the upper extremities, etc.) * moles, wounds, scars or tattoos in the area to be treated or tested * lack of ability to cooperate • * current use of medications that may affect the trial such as antihistamines and pain killers. * skin diseases * consumption of alcohol or painkillers 24 hours before the study days and between these - acute or chronic pain • * participation in other trials within 1 week of study entry (4 weeks in the case of pharmaceutical trials)
clonidine-induced spinal acetylcholine release: normal volunteers vs. neuropathic pain

Conditions: Pain

Summary: the purpose of this study is to compare the amount of acetylcholine release after a single injection of clonidine in normal volunteers and individuals with neuropathic pain.

this study is part of a pain center grant that focuses on how pain, especially chronic neuropathic pain, alters the response to traditional and non-traditional analgesics (pain medications). the way that nerve fibers carry pain information to the brain is thought to change after surgery and in cases of chronic pain. for this reason, some medicines work better to relieve pain in healthy people who have a sudden painful injury when compared to people after surgery or to people with chronic pain. currently available pain medications may not relieve all types of pain or may relieve pain only at doses that produce side effects and potential complications. the aim of this study is to understand the mechanisms by which intrathecal clonidine (or clonidine injected into cerebrospinal fluid) increases in potency and efficacy by examining the cerebrospinal fluid of healthy individuals, before and after clonidine administration, as well as looking at the spinal fluid of people with chronic neuropathic nerve pain. more specifically, in this study, researchers will compare acetylcholine release (a protein-like substance found in cerebrospinal fluid) in normal volunteers and patients with neuropathic pain after a single injection of clonidine. after baseline measurements, including blood pressure and heart rate, participants will be trained to accurately estimate pain by way of thermal heat testing. next a small amount of spinal fluid will be withdrawn from each participant to measure the amounts of naturally-made chemicals in the participants' cerebrospinal fluid. participants then will receive an injection of clonidine. after the injection, additional samples of spinal fluid will be taken to measure chemical changes in the fluid. duration of the study for participants is 1 day, and includes 1 visit to the research center, lasting approximately 3 hours.

Eligibility criteria:
inclusion criteria: * healthy adult volunteers * patients with neuropathic pain exclusion criteria: * pregnancy * allergy to clonidine * currently taking clonidine or other direct a2-adrenergic agonists * taking cholinesterase inhibitors

Keywords: pain, chronic pain acetylcholine clonidine a2-adrenergic agonists alpha2-adrenergic agonists
a trial investigating the effect of a treatment with zinkgluconaat for verrucae vulgares

Conditions: Verrucae Vulgares

Summary: a double-blind, placebo-controlled trial investigating the effect of a treatment with zinkgluconaat for verrucae vulgares

a double-blind, placebo-controlled trial investigating the effect of a treatment with zinkgluconaat for verrucae vulgares

Eligibility criteria:
inclusion criteria: * patients with verrucae vulgares exclusion criteria:
mutyh-associated polyposis

Conditions: MutYH-associated Polyposis

Summary: this is single-center, prospective, non-randomized study

the study will include patients with more than 3 polyps, without mutations in the apc gene. using molecular genetic research methods (polymerase chain reaction, sscp, sequencing by sanger method) mutations in the mutyh gene will be studied. for all patients with mutations in the mutyh gene, an optimal diagnostic algorithm will be developed. the significance of monoallelic mutations in the mutyh gene will be determined. clinical monitoring will be defined. optimal amount of surgical intervention will be suggested.

Eligibility criteria:
inclusion criteria: 1. patients with multiple colon polyps (n polyps = 4+) 2. patient consent to participate in the study exclusion criteria: 1. presence of mutations in the apc gene 2. patient's refusal to participate in the study

Keywords: mutyh-associated polyposis familial adenomatous polyposis biallelic mutation monoallelic mutation colproctectomy
comparative effect of mechanical and functional alignment in bilateral total knee arthroplasty on ankle alignment

Conditions: Arthropathy of Knee

Summary: mechanical alignment (ma) in total knee arthroplasty (tka) is the most commonly used with well-documented long-term results, however 20% of patients express dissatisfaction following primary tka. alternative alignment philosophies have been proposed, aiming to improve patient clinical outcomes and satisfaction. however, evaluation is focused mainly on knee alignment, the pathological findings and other adaptational changes in the ankles and hips are usually neglected. thia study aim to comparative effect between mechanical and functional alignment in patient undergone bilateral robotic tka on ankle alignment and functional outcomes.


Eligibility criteria:
inclusion criteria: * age 20-80 years * symptomatic bilateral knee osteoarthritis requiring primary tka * willing to undergo bilateral simultaneous tka * able to give informed consent exclusion criteria: * ligament deficiency requiring constrained prosthesis * bone loss with augmentation need * history of fracture around knee or previous osteotomy * history of ankle fracture * patient with neuromuscular disorder or movement disorder * patient is unable to attend the study follow-up program
preoperative ppi in sleeve gastrectomy

Conditions: Morbid Obesity

Summary: he purpose of this study is to study the effect of preoperative ppi in the early outcome of sleeve gastrectomy

in this study 200 morbidly obese patients will be included and will be undergone sleeve gastrectomy. the patients will be randomly assigned into 2 groups, group 1 will be receive ppi preoperative for 10 day and group 2 will not

Eligibility criteria:
inclusion criteria: * morbidly obese patient with bmi more than 40 with or without co-morbidity * morbidly obese patient with bmi more than 35 with co-morbidity exclusion criteria: * unfit patients for laparoscopic sleeve gastrectomy * patients refuse to share in the study * patients that already on ppi due to any indications * revisional surgery for obesity * previous upper abdominal surgery
access to infertility services: clinic perspective

Conditions: Infertility

Summary: since the identification of the human immunodeficiency virus (hiv) and the acquired immunodeficiency syndrome (aids) in the 1980s, there have been significant advances made in the management and long-term prognosis for infected individuals. currently, with the advent of highly active antiretroviral therapy (haart), hiv-positive individuals may live a healthy and productive life for years to decades after diagnosis. as life expectancy has increased, this group of people has begun to engage in family planning. this has created a need for access to advanced reproductive technologies and fertility treatments. while attempting to achieve pregnancy, utilization of these services can help to minimize the risk of transmission in serodiscordant couples, and can allow treatment of subfertile couples. access to these services may be limited in ontario for a variety of reasons. the purpose of this study is to determine the access to infertility clinics and services in ontario for couples in which one or both partners is infected with hiv.


Eligibility criteria:
inclusion criteria: * all ontario clinics offering advanced reproductive/infertility services exclusion criteria: * none

Keywords: infertility services, hiv, pregnancy planning
randomized trial of arcon in larynx cancer

Conditions: Larynx Carcinoma

Summary: title: a multicentre, randomised, phase iii clinical trial comparing accelerated radiotherapy with accelerated radiotherapy plus carbogen and nicotinamide (arcon) in clinical stage t2-4 laryngeal carcinoma. primary objective: does the addition of carbogen and nicotinamide to a schedule of accelerated radiotherapy in patients with clinical stage t2-4 laryngeal carcinoma improve local primary tumour control? definitive analysis will be performed on local control rates at two years after completion of radiotherapy. secondary objectives: does the addition of carbogen and nicotinamide * increase the larynx preservation rate? * increase the regional control rate? * increase the toxicity of accelerated radiotherapy? * improve the overall quality of life? * improve the disease-free survival? * improve the overall survival? study design: an open-label, randomised clinical trial assigning patients in a 1:1 ratio to one of the following treatment arms: * accelerated radiotherapy * accelerated radiotherapy plus carbogen and nicotinamide patient characteristics and number: 344 patients with clinical t2-4 laryngeal carcinoma measurements: * time to local failure * time to regional failure * survival with functional larynx * overall and disease-free survival * frequency and severity of complications related to radiotherapy and carbogen and nicotinamide * quality of life assessment


Eligibility criteria:
inclusion criteria: * pathological confirmed squamous cell carcinoma of the larynx. * tnm-classification (uicc 1997, appendix i): * t3-4 glottic or supraglottic carcinoma * t2 glottic carcinoma with impaired cord mobility or subglottic extension * t2 supraglottic carcinoma with invasion of mucosa of base of tongue or vallecula or invasion of the medial wall of the piriform sinus. * any n-stage, m0. * who performance status 0 or 1 (appendix ii). * age \> 18 years. * written informed consent. * quality of life questionnaire completed. exclusion criteria: * prior or concurrent treatment for this tumour. * severe stridor and adequate debulking of airway not possible. * impaired renal function: serum creatinine above upper normal limit. * use of nefrotoxic medication (including ace-inhibitors) that cannot be discontinued for the duration of the radiation treatment. * impaired hepatic function: asat and alat more than 1.5 times the upper normal limit. * use of anti-convulsants that cannot be discontinued for the duration of the radiation treatment. * history of malignancy during the previous 5 years except basal cell carcinoma of skin, carcinoma in situ of the cervix, or superficial bladder neoplasm (pta).

Keywords: larynx carcinoma radiotherapy carbogen nicotinamide
preoperative physical activity intervention in patients before planned liver resection for cancer (apache)

Conditions: Primary Liver Cancer; Secondary Liver Cancer; Liver Metastases

Summary: the aim of this study is to assess the impact of preoperative physical activity on physical capacities of patients undergoing liver resection for primary or secondary liver cancer.

the purpose of this study is to investigate the effects of a preoperative exercise program in patients with primary or secondary liver cancer undergoing hepatectomy. preoperative exercise programs have been shown to be effective in other cancer populations, but have been poorly studied in patients with liver cancer. for these patients, it remains unclear what the optimal composition of such programs should be and how they should be delivered. outcome measures in this study will include preoperative outcomes (oxygen consumption, quality of life, fatigue and physical activity level, anthropometric measures, plasma concentrations of hepatokines) and postoperative outcomes (length of hospital stay and postoperative complications). after the study is explained and consent obtained, subjects will be tested on a submaximal exercise on cycloergometer with gas exchanges analysis and with pre and post blood test. then, they will answer various questionnaires assessing physical activity, quality of life and fatigue. patients scheduled for liver resection will be randomized to one of two groups. the first group (experimental group) will be subdivided into two groups: interval training 1 and interval training 2, which differentiate themselves by two different intensities.the second group (control group) will receive standard care. the prehabilitation program will last 6 weeks with 3 sessions per week and will consist in two interval training programs on a cycloergometer with two different intensities. one month after surgery, peri and postoperative complications will be noted.

Eligibility criteria:
inclusion criteria: * men and women aged \>18 years old. * patients with primary liver cancer, biliary tract cancer, liver metastasis endorsed in the university hospital of besancon * no opposition of patients * join a french social security or receiving such a scheme exclusion criteria: * legal incapacity or limited legal capacity * patients being in the disqualification of another study or under the national register of volunteers * patients unlikely to cooperate or anticipated low cooperation * patients with a maximal oxygen consumption above 35 ml/min/kg

Keywords: exercise adapted physical activity preoperative liver resection hepatectomy
study of posaconazole in the treatment of invasive fungal infections (study p02095)

Conditions: Mycoses

Summary: this study is designed to evaluate the safety, tolerance and efficacy of posaconazole (sch 56592) under an open label, treatment protocol for subjects with invasive fungal infections: a. which are refractory or resistant to standard antifungal therapies; b. for which there are currently no effective therapies; c. with a prior history of serious, severe or life-threatening toxicities while receiving antifungal therapy; d. with pre-existing organ dysfunction which precludes the administration of standard antifungal therapies.

the current clinical trial is designed to provide posaconazole (sch 56592 to subjects with invasive fungal infections a) which are refractory or resistant to standard antifungal therapies or b) for which there are currently no effective therapies. subjects with such invasive fungal infections cannot be enrolled in controlled, randomized clinical trials. secondly, this clinical trial is also designed to provide posaconazole (sch 56592) to subjects with invasive fungal infections who c) have experienced serious or severe toxicities while receiving standard antifungal therapies or d) have pre-existing organ dysfunction such as renal dysfunction who require standard antifungal therapy which is precluded because of the toxicities associated with such therapy. this clinical trial also serves to allow collection of preliminary data regarding the safety and efficacy of posaconazole (sch 56592) against a variety of invasive fungal infections which although serious and life-threatening are sufficiently rare so that they cannot be studied in a controlled, randomized clinical trial. this is an open-label, treatment protocol for a multi-center study of posaconazole (sch 56592) 200mg orally four times daily (qid) while hospitalized followed by posaconazole (sch 56592) 400mg orally twice daily (bid) on discharge from hospital, in the treatment of invasive fungal infections. approximately 320 subjects have been enrolled at 160 clinical study centers in the us and worldwide.

Eligibility criteria:
inclusion criteria: * proven or probable invasive fungal infections according to eortc/msg criteria. * ifi are documented to be refractory to standard antifungal therapy or intolerant to standard therapy. * able to take oral medication or take medication via enteral feeding tube. exclusion criteria: * history of serious or severe hypersensitivity or idiosyncratic reactions to azole antifungals. * concurrent progressive neurological disease (except if due to invasive fungal infection) * use of medications that are known to interact with azoles and that may lead to life-threatening side effects: terfenadine, cisapride, ebastine at entry or within 24 hours prior to therapy, or astemizole at entry or within 10 days prior to entry.concentration/efficacy of azole antifungals: rifampin, carbamazepine. * females pregnant or nursing.

Keywords: aspergillosis, candidiasis, cryptococcosis, phaeohyphomycosis invasive fungal infections
td-1792 in gram-positive complicated skin and skin structure infection

Conditions: Staphylococcal Skin Infection

Summary: the purpose of this study is to determine whether td-1792 is safe and effective when used to treat complicated skin and skin structure infections caused by gram-positive bacteria.

td-1792 is compared to vancomycin for the treatment of csssi.

Eligibility criteria:
inclusion criteria: * major abscess requiring surgical incision and drainage,infected burn, deep/extensive cellulitis, infected ulcer, wound infections * requires at least 7 days of intravenous antibiotic treatment exclusion criteria: * more than 24 hours of antibiotic therapy * moderate or severe liver disease * severely neutropenic * baseline qtc \> 500 msec, congenital long qt syndrome, uncompensated heart failure, uncorrected abnormal k+ or mg++ blood levels or severe left ventricular hypertrophy

Keywords: csssi staph mrsa
acceptance-based treatment for generalized anxiety disorder

Conditions: Anxiety Disorders; Generalized Anxiety Disorder

Summary: this study will develop and implement an awareness- and acceptance-based for treatment of individuals with generalized anxiety disorder.

participants in this study are recruited from intakes at the center for anxiety and related disorders at boston university. participants will be randomly assigned to receive either acceptance and mindfulness-based strategies plus cognitive behavioral therapy or no treatment for 16 weeks. the treatment will involve daily practice of mindfulness techniques to help draw attention to and accept various emotional states. interviews, questionnaires, and depression and anxiety scales will be used to assess participants. assessments will be conducted post-treatment and at 3- and 9-month follow-up visits.

Eligibility criteria:
inclusion criteria: * generalized anxiety disorder (gad) * willing to maintain medication levels and refrain from any additional psychosocial treatment during the course of the study exclusion criteria: * bipolar disorder, psychotic disorder, or substance dependence
tracheal positive pressure during high flow nasal oxygen administration in critically ill patients: a physiologic study.

Conditions: Acute Respiratory Failure; High Flow Nasal Cannula; Critically Ill; Airway Disease; Positive End Expiratory Pressure; Diaphragm Disease

Summary: high flow nasal cannula administration in critically ill patients is frequently used to improve acute respiratory failure or to prevent respiratory failure after extubation. it acts generating a mild positive pressure in the airways and by reducing respiratory effort of patients. however to the best of our knowledge, no study to date has directly measured the amount of positive pressure generated in the trachea of patients. the primary aim, therefore, of this study measures this positive pressure after extubation in critically ill patients.


Eligibility criteria:
inclusion criteria: critically ill patients after mechanical ventilation lasted at least 72 hours * age 18-80 years exclusion criteria: * copd stage \>1 according to gold classification * end stage organ disease (liver, kidney, heart, lung) * neuromuscular disease * neoplasm * previous tracheostomy * obesity with bmi \> 35 kg/m2 * non collaborative patient

Keywords: intensive care unit, critically ill patient, high flow nasal cannula, peep, respiratory failure, non invasive ventilation
immune activation, hypoxia and vasoreaction in sepsis of pulmonary versus abdominal origin

Conditions: Sepsis

Summary: sepsis remains a common entity in critical care patients with remarkable mortality. pulmonary and abdominal infections (with subsequent sepsis) are the most common in the icu. despite extended research activities, no differences in patient outcome or organ dysfunction were revealed. sepsis is a complex immune reaction phenomenon based on unbalanced activation and suppression. in addition to changes of cytokine levels and immune cell activity, underlying genetic reactions are present. for instance, expression of mirna (as a potential important step of immune cell activation) is likely changed during systemic and local immune reactions. the aim of this study is to perform a detailed assay of immune cell activation, to investigate the levels of pro- and antiinflammatory cytokines and the various expression of mirna depending on the origin of infection in the two most common sides. this means in icu patients with early pulmonary or abdominal sepsis as well as in healthy controls. additionally, clinical parameters of organ function, current infection markers as crp and procalcitonin, cardiovascular function and heart rate variability will be assessed. parameters of local tissue perfusion in a dynamic testing during forearm ischemia and plasma adenosine concentration will be measured.


Eligibility criteria:
inclusion criteria: * sepsis (according to the criteria of the international sepsis definition conference) exclusion criteria: * pregnancy * malignancy * corticoid therapy * organ transplantation * renal insufficiency with hd

Keywords: sepsis tissue oxygenation tissue perfusion immune reaction
therapeutic effect of an herbal medicine on anxiety

Conditions: Anxiety Disorders

Summary: phase iii, double blind, randomized study, controlled by valeriana officinalis l for evaluating the efficacy of association of passiflora incarnata l; crataegus oxyacantha l and salix alba l. in generalized anxiety disorder. the treatment period will last four weeks and be followed by a post treatment visit.

the main objective of this study is to evaluate the clinical efficacy of the drug passiflorine® (passiflora incarnata l; crataegus oxyacantha l and salix alba l) compared to valeriana officinalis over a period of four weeks. the improvement of anxiety disorders parameters (primary outcome) will be measured by the score of the hamilton anxiety scale (ham-a). does the administration of 2 tablets a day over a period of four weeks vs. valeriana officinalis lead to an improvement in anxiety disorders?

Eligibility criteria:
inclusion criteria: * clinical diagnosis of generalized anxiety disorder * ham-a scale \> 17 and \<30 exclusion criteria: * ham-a scale \> 30 * psychotherapy

Keywords: herbal phytotherapy passiflora valeriana anxiety