Kornimate/medical-research-clean huggingface dataset:
correlation of cerebral state index with the richmond agitation-sedation scale in mechanically ventilated icu patients

Conditions: Sedation; Analgesia

Summary: the purpose of this study is to correlate the cerebral state index obtained from a cerebral state monitor with the richmond agitation-sedation scale assessment performed on sedated and mechanically ventilated intensive care patients.

currently there are no objective methods to measure levels of sedation in all icu patient populations. this generally does not become problematic in most patients. however, certain populations cannot be assessed by standard means. these populations would include patients who are quadriplegic and those who are being treated with neuromuscular blocking agents. the current norm is to use a sedation scale such as the richmond agitation-sedation scale to assess the patient's level of sedation. an alternative to this would be to use an eeg based method that monitors brain activity. new methods of monitoring brain activity, using cerebral state monitors may provide an effective means of monitoring sedation. the cerebral state monitor, however, and the parameters it provides, the cerebral state index, has not been tested in an icu setting. correlating the measurements gained from the cerebral state monitor with the rass assessment from sedated icu patients may allow us to develop a method of monitoring sedation in populations that were impossible to monitor previously. accurately monitoring the level of sedation in these patients may help decrease the incidence of over-sedation and under-sedation.

Eligibility criteria:
inclusion criteria: * admission the surgical-trauma intensive care unit at the charleston area medical center general hospital * adult (18-85 years of age) * anticipated duration of mechanical ventilation of at least 72 hours exclusion criteria: * patients admitted with paralysis or a brain injury * patients who are deaf, blind, or have pre-existing dementia/delirium

Keywords: sedation analgesia mechanical ventilation cerebral state monitor cerebral state index
database of all patients with microbiologically proven mycobacteria tuberculosis infection

Conditions: Tuberculosis

Summary: prospective data collection of all patients with microbiologically proven mycobacteria tuberculosis infection treated at singapore general hospital.

tuberculosis currently infects one third of the world's population and is responsible for killing approximately 2 million individuals annually. this is a major public health concern worldwide, and there has been a huge impetus to implement strategies for better tuberculosis control. the investigators have established a system to track all patients with microbiologically proven tuberculosis treated at singapore general hospital, with vigilant recording and reporting systems, from the first instance when patients were diagnosed to the time they have completed anti-tuberculosis chemotherapy. the investigators endeavour to use this system to improve patient care by adopting patient-supportive approaches that lead to high compliance rates and best possible outcomes of treatment.

Eligibility criteria:
inclusion criteria: 1) all patients with microbiologically proven mycobacteria tuberculosis infection treated at the singapore general hospital.

Keywords: tuberculosis
medical utilization in israel during second intifada

Conditions: Anxiety; Depression; Stress

Summary: in this ecological study we examine the impact of stress from repeated terrorist attacks during the second initifada on medical utilization by the israeli population. we hypothesize that in weeks following serious terror attacks there will be an increase in prescriptions for psychiatric medications and an increased number of unexplained somatic complaints. we will also examine associations with overall medical utlization. we will consider age, gender and effects of geographic poximity to location of attacks.


Eligibility criteria:
inclusion criteria: ecological study we will examine patterns of visits and prescirptions for all participants in two large health provider institutions in israel. exclusion criteria: none - ecological study
laryngeal motor evoked-potentials as a biomarker of vagus nerve stimulation in epileptic patients

Conditions: Epilepsy

Summary: the goal of this study is to record and characterize larynx evoked motor potentials induced by vagus nerve stimulation. this study will include 10 adult patients implanted with a vagus nerve stimulator, followed at the center for refractory epilepsy at cliniques st luc. the inclusion criteria are: (1) patient aged between 18 and 65 years ; (2) cervical vns device (cyberonics, houston, tx, usa) implanted for at least 6 months, (3) normal electrode impedance of the electrode. exclusion criteria are (1) presence of a concomitant laryngeal pathology or recurrent laryngeal nerve damage, independent from vns ; (2) important vns side effects reported by the patient, such as severe dyspnea (grade iii-iv) or severe pain in the neck/ear region.


Eligibility criteria:
inclusion criteria: * patients aged between 18 and 65 years * vagus nerve stimulation implanted for at least 6 months * no impedance issues with the vns electrode exclusion criteria: * presence of a concomitant laryngeal pathology or rln damage, independent from vagus nerve stimulation * important side effects of the vns reported by the patient such as dyspnea, pain in neck/ear region and gastrointestinal complaints.

Keywords: epilepsy
the link between physical activity and brain health in healthy adults

Conditions: Alzheimer Disease; Inactivity; Preventive Therapy

Summary: the goal of this observational study is to investigate the cross-sectional relationship between physical activity and brain health from a multiscale approach (neuropsychology, neuroimaging, peripheral biomarkers and genetics) in former athletes and sedentary individuals. the main question it aims to answer is: do former athletes have better brain structure than sedentary people? evaluating the differences in neurodegenerative processes between competitive training and sedentary and inactivity.


Eligibility criteria:
inclusion criteria: * group a: ex-athletes and continue to perform regular physical exercise (minimum 3 days/week of moderate-vigorous intensity). * group b: sedentary individuals, (i.e., perform \<150 min of moderate intensity exercise per week or ipaq score\<600 met min/week). * in both groups (a and b) the conditions of physical exercise or sedentary lifestyle must have been maintained for at least 6 months prior to the evaluations. * not having a history of neurological or psychiatric disorder or suffering from a serious medical condition exclusion criteria: * medical conditions that have a high risk of associated cognitive symptoms. * severe head injury with loss of consciousness within the previous 5 years. * alcoholism (\>3 alcoholic drinks per day). * chronic use of anxiolytics, neuroleptics, narcotics, anticonvulsants, or sedative hypnotics. * hearing or visual impairment that would preclude testing * history of neurological disease with clinically relevant impact on cognition (e.g. cerebrovascular disease). * incidental structural brain findings with impact on cognitive impairment or survival (e.g., malignant brain tumor). * presence of severe systemic disease (e.g., cancer under treatment). * consumption of anabolic substances. * problems understanding spoken or written spanish. * those with pacemakers or metallic implants that may interfere with the mri.

Keywords: physical activity
tracking response in advance of investigational trials, borderline study

Conditions: Borderline Personality Disorder

Summary: trait-bor is an open-label psychotherapy treatment study for adults who meet the diagnostic criteria for borderline personality disorder (bpd) and are seeking enrollment in a clinical trial of a novel compound to treat bpd. the current study seeks to determine if there are therapeutic benefits to more infrequent, short term, or longer term supportive psychotherapy.


Eligibility criteria:
inclusion criteria: * participant has signed an icf prior to any study-specific procedures being performed. * participant has a diagnosis of borderline personality disorder, per dsm-5 criteria, as confirmed on the mini, and ≥ 16 aapi-cr total score. * participant is in good physical health, and, in the opinion of the investigator, is a suitable candidate for treatment with monthly supportive psychotherapy. * participant is 18 to 65 years old. * for participants already receiving psychotherapy, including dialectical behavioral therapy (dbt), they must continue their regular course of treatment for the duration of the current study. exclusion criteria: * participant is pregnant, breast-feeding, or planning to become pregnant. * a history or presence of a clinically significant hepatic, renal, gastrointestinal, cardiovascular, endocrine, respiratory, immunologic, hematologic, dermatologic, or neurologic abnormality, which in the opinion of the investigator may impact participant safety or study results. * participant has a history of any psychiatric condition other than bpd, which in the opinion of the investigator is primary, or any other psychiatric or neurologic disorder or symptom that could pose undue risk to the participant or compromise the study. * any participant who represents an acute suicidal risk in the opinion of the investigator, as defined by a "yes" response to suicidal ideation on questions 4 or 5, or answer "yes" to suicidal behavior questions on the cssr-s within 90 days of screening. * any participant who represents an acute homicidal risk in the opinion of the investigator. * moderate or severe substance use disorder within 90 days prior to screen, according to dsm-5 criteria that in the opinion of the investigator could pose undue risk to the participant, or compromise the study. * any condition that, in the opinion of the investigator, makes the participant unsuitable for the study. * participants who require ongoing treatment with typical antipsychotics.
neuropathic pain after orchidectomy and sex reassignment surgery

Conditions: Neuropathic Pain; Phantom Pain; Sex Reassignment Surgery

Summary: phantom pain is associated with cortical reorganization after amputation. this phenomenon should not play a role in transsexual women, since the cortical representation of the male sex organs is presumably altered. the study investigates the incidence of phantom pain in this patient population. for this study the following question should be investigated: is the incidence of phantom pain and local chronic postsurgical pain lower in sex reassignment surgery from male to female compared to inguinal tumor orchidectomy?

phantom pain is a common and much studied phenomenon after amputation.the loss of visceral organs is also associated with phantom pain. under entirely different conditions than the removal of a tumorous testicle, sex reassignment surgery from male to female sex occurs in transsexual women. in this operation, parts of the penis and both testicles are removed and a plastic surgical transformation is made into a female genital.the surgical trauma is greater compared to an orchidectomy. the sex reassignment surgery is expressly desired, the amputated tissues are rejected or perceived as not belonging to the patient's own body and thus do not appear as a loss. the group of patients with tumor orchidectomy acts as a control group. in addition to the incidence of phantom pain and chronic local postoperative pain in comparison between the two groups, the secondary objectives of the study were defined as the occurrence of phantom pain, the type of pain and the intensity of pain. two patient groups were compared, the group after sex reassignment surgery (gac) and the group after inguinal orchidectomy for testicular tumor (orc). a total of 265 transgender women were written to, 46 of whom had undergone surgery in tübingen and 219 in munich. the operations took place between 2002 and 2014. for the group of patients after orchidectomy, 158 men who had undergone surgery in tuebingen between 2010 and 2014 were contacted by letter. the pseudonymization was done with a combination of letters and numbers, which were created with a key generator program. the patients received a questionnaire divided into several categories, these categories were questions on demography, pre- and postoperative pain as well as phantom pain, pain processing, quality of life, sex life and urological questions.

Eligibility criteria:
inclusion criteria: * surgery at least 6 month before data collection * german speaking exclusion criteria: -
white spot lesions development in mixed dentition patients

Conditions: Anterior Functional Shift

Summary: 36 patient will be divided into two equal groups. one for removable inclined plane while the other will be treated using clear aligner appliances. evaluation of the white spot lesion will be accumplished for all patients clinically before anr after completion of treatment.

the sample size was calculated using g\*power (version 3.1.9.4; germany) and designed to have a power of 82% assuming type i statistical error of 5% and one-tailed statistical test based on azeem and hamid.13 the calculated sample was 15 patients in each group. the sample will be increased to include 36 patients: 18 patients per group for a 20% expected loss. patients with the age range of 9 to 12 years will be selected for the study. all patients and their parents will be informed of the procedures and will sign the informed consent. patients who had periodontal diseases, bone resorption cleft lip and palate deformities, orofacial syndrome, hypoplastic enamel defects, and multiple restorations on the facial surfaces or unable to maintain good oral hygiene will be excluded from the study. all patients will be randomly allocated into two groups according to the management protocol: inclined plane and clear aligner. the patients will be examined for any white spot lesion on the labial surface of the teeth in the upper and lower jaws clinically and using lateral and frontal intraoral photographs immediately before treatment and monthly along the treatment procedures. each tooth will be evaluated, and the total lesions count will be recorded for each patient. all patients will be instructed to maintain good oral hygiene using fluoridated toothpaste daily. statistical analysis: the incidence of the wsl in each tooth and the total lesions count will be calculated for each patient. these data will be collected and subjected to the appropriate statistical tests using the spss version 20.0 software for windows (ibm, usa).

Eligibility criteria:
inclusion criteria: * patients with the age range of 9 to 12 years with anterior crossbite will be selected for the study exclusion criteria: * periodontal diseases, bone resorption cleft lip and palate deformities, orofacial syndrome, hypoplastic enamel defects, and multiple restorations on the facial surfaces or unable to maintain good oral hygiene

Keywords: white spot lesion mixed dentition patients clear aligner anterior functional shift
study of safety and efficacy of refacto af in previously untreated hemophilia a patients in the usual care setting

Conditions: Hemophilia A

Summary: study to evaluate the safety and effectiveness of refacto af for the treatment of severe hemophilia a in patients who have not yet received treatment for their hemophilia. study subjects will be males less than 6 years old who have not taken any clotting factor or other blood products before the study. the safety and effectiveness of refacto af will be determined in this study by tests and procedures done at the doctor's office.

regulatory commitment

Eligibility criteria:
inclusion criteria: * male subjects \<6 years of age with severe hemophilia a (fviii:c \<1%) based on clinical records, including newborns. * no prior exposure to factor products or any blood products. exclusion criteria: * presence of any bleeding disorder in addition to hemophilia a. * treatment with any investigational agent or device within the past 30 days. * any condition(s) that compromises the ability to collect study-related observations, or that poses a contraindication to study participation (these conditions include, but are not limited to, inadequate medical history to assure study eligibility; and expectation of poor adherence to study requirements).

Keywords: refacto af factor viii inhibitors antibodies
gonadotropin-releasing hormone antagonist on triggering day: a randomized controlled study

Conditions: Infertility

Summary: gonadotropin-releasing hormone (gnrh) antagonists have been widely used for the prevention of premature luteinizing hormone (lh) surges during controlled ovarian hyperstimulation (coh) for in vitro fertilization and embryo transfer (ivf-et) since the late 1990's. many years have passed since gnrh antagonists were introduced to prevent premature lh surges during stimulated cycles. however, there is still no consensus on the optimal gnrh antagonist protocol. attempts at modifying gnrh antagonist protocols have been made to improve coh outcomes. however, a meta-analysis of 27 randomized controlled trials, including recent reports, showed significantly lower clinical ongoing pregnancy rates in the antagonist group. thus, additional efforts are needed to identify the optimal stimulation protocols to achieve better follicular and embryonic development and to improve the pregnancy rates in coh using gnrh antagonist. given the assumption of a detrimental effect of gnrh antagonist on the pregnancy rate, with current protocols, we hypothesized that a shorter duration of gnrh antagonist administration might improve outcome.


Eligibility criteria:
inclusion criteria: * both ovaries present with no morphological abnormalities * normal ovulatory cycle with cycle lengths of between 25 and 35 days * basal serum fsh (day 3) level of \< 15 miu/ml * body mass index (bmi) ranging between 18 and 27 kg/m2 exclusion criteria: * history of a poor ovarian response * evidence of endocrine abnormalities, such as, hyperprolactinemia, thyroid dysfunction, or polycystic ovary syndrome * hydrosalpinx * severe endometriosis (stage iii-iv)
effectiveness of patient-centered community health worker support to help patients control chronic disease

Conditions: Obesity; Diabetes; Hypertension; Asthma/COPD With Tobacco Dependence

Summary: the purpose of this proposal is to compare the effectiveness of community health worker (chw) support vs. usual primary care for helping chronically-ill, low-ses patients to improve control of chronic conditions. upon enrollment each patient will select one of their multiple chronic conditions as a focus for the trial and work with his/her pcp to set a chronic disease management goal. patients are then randomized to receive usual primary care vs. chw support for moving towards that goal.


Eligibility criteria:
inclusion criteria: * patient of target practices for at least 1 yr defined as having one office visit within preceding 12 month * home zip code including any of the following: 1. 19104 2. 19131 3. 19139 4. 19143 5. 19146 * 2 or more of the following conditions: 1. obesity (bmi greater than 30), 2. htn (icd9 relating to htn in emr), 3. dm (icd9 relating to dm in emr), 4. asthma/copd and tobacco dependence (icd9 for asthma or copd in emr and documentation of tobacco use) * uninsured, insured by medicaid or dually eligible for medicaid/managed medicare * patients who have scheduled appointments in the future. exclusion criteria: * will not provide informed consent for this study. * does not have the capacity to provide informed consent for this study. * previously enrolled in this study

Keywords: multiple chronic conditions
autonomic dysreflexia in spinal cord injury

Conditions: Autonomic Dysfunction; Spinal Cord Injured

Summary: autonomic dysreflexia in high spinal cord-injured can be initiated by a full bladder or bowel, or when trying to empty either. this randomised study aims at evaluating whether irrigation procedure or digital stimulation or evacuation of the rectum is less provocative of autonomic dysreflexia. participants have their bowels emptied on different days, in the morning fasting. bladder filling with sterile saline water is evaluated on a third day as a control.


Eligibility criteria:
inclusion criteria: 1. people with a spinal cord injury above th6 and with symptoms of autonomic dysreflexia. 2. at least one year post injury. 3. 18 years or older. 4. informed consent. exclusion criteria: 1. usage of prophylactic anti-autonomic dysreflexia medication. 2. pregnant or breastfeeding. 3. people who is not able to follow the sudy protocol. 4. no former major surgery in the abdomen or pelvic region. 5. no former radiotherapy in the pelvic region.

Keywords: autonomic dysfunction spinal cord injured neurogenic bowel neurogenic bladder
evaluation of the shape up rhode island campaign

Conditions: Obesity

Summary: obesity is a major health problem that has reached epidemic levels. efforts are needed to develop cost-effective public health approaches for weight loss and maintenance. one such approach is to develop team-based programs that may motivate people to lose weight and/or increase their physical activity. one such program is entitled shape-up rhode island (suri). the purpose of this project is to evaluate the overall effectiveness of suri and to test if a behavioral intervention can enhance the effectiveness of the original program. the current trial is investigating whether adding a behavioral intervention delivered online would enhance the outcomes of suri participants.

background: given the epidemic of obesity, approaches to weight loss that can be applied on a community, state, or national level are needed. this project is an ongoing evaluation of shape up rhode island (suri) program, a state-wide internet based program involving team-based competition to increase physical activity and achieve weight loss. aim: to enhance the effectiveness of suri utilizing a minimal contact intervention delivered online. design: suri 2008 participants were invited to join a research study focusing on weight loss. interested participants were randomized to two groups including a suri enhanced (behavioral intervention presented in 12 weekly online presentations) or a suri standard group (group given a list of previously existing online resources to aid with weight loss).

Eligibility criteria:
inclusion criteria: * overweight or obese * current participant in the shape up ri program weight loss competition exclusion criteria: * none

Keywords: obesity weight loss internet