Kornimate/medical-research-clean huggingface dataset:
a study of rhbmp-2/cpm in closed fractures of the humerus

Conditions: Fractures

Summary: the primary objective of this study is to assess whether fracture union is accelerated in subjects with humeral fractures (proximal,diaphyseal) treated with conservative therapy (standard of care) and a single dose of rhbmp-2/cpm compared to subjects who receive standard of care alone.


Eligibility criteria:
inclusion criteria: * skeletally mature subjects age 18 years or older. * subjects with either a closed proximal humeral fracture or a diaphyseal humeral fracture. * treatment plan that includes only conservative (nonoperative) therapy within 48 hours following injury. exclusion criteria: * shoulder dislocation at the time of injury. * planned procedure(s) at that would stimulate fracture union at the time of application of the initial immobilization device. * fractures located in the distal third of humerus.

Keywords: fracture humerus
active warming in prehospital trauma care

Conditions: Body Core Temperature; Thermal Comfort

Summary: prevention and treatment of hypothermia by active warming in prehospital trauma care is recommended but scientifical evidence of its effectiveness in a clinical setting is scarce. the objective of this study was to evaluate the effect of additional active warming during road or air ambulance transportation of trauma patients. patients were assigned to either passive warming with blankets or passive warming with blankets with the addition of an active warming intervention using a large chemical heat pad applied to the upper torso. ear canal temperature, subjective sensation of cold discomfort and vital signs were monitored. mean core temperatures increased from 35.1°c (95% ci; 34.7-35.5 °c) to 36.0°c (95% ci; 35.7-36.3 °c) (p\<0.05) in patients assigned to passive warming only (n=22) and from 35.6°c (95% ci; 35.2-36.0 °c) to 36.4°c (95% ci; 36.1-36.7°c) (p\<0.05) in patients assigned to additional active warming (n=26) with no significant differences between the groups. cold discomfort decreased in 2/3 of patients assigned to passive warming only and in all patients assigned to additional active warming, the difference in cold discomfort change being statistically significant (p\<0.05). patients assigned to additional active warming also presented a statistically significant decrease in heart rate and respiratory frequency (p\<0.05). in mildly hypothermic trauma patients, with preserved shivering capacity, adequate passive warming is an effective treatment to establish a slow rewarming rate and to reduce cold discomfort during prehospital transportation. however, the addition of active warming using a chemical heat pad applied to the torso will significantly improve thermal comfort even further and reduce the cold induced stress response.


Eligibility criteria:
inclusion criteria: * subjects were sequential trauma patients, age ≥ 18 years, who had sustained an injury outdoors and were transported by one of the participating ems units. exclusion criteria: * patients were excluded if initial level of consciousness was affected, (glasgow coma scale \< 15), if they required prehospital cpr or if duration of transportation was expected to be shorter than 10 minutes. * as the aim of the study was to investigate the effect of active warming intervention in cold stressed patients, those patients who had already received active warming or had been taken indoors for more than 10 minutes before ems unit arrival or had an initial cold discomfort rating ≤ 2 were also excluded.

Keywords: hypothermia, body temperature regulation,thermal comfort, active warming, passive warming, prehospital trauma care
barbed reposition pharyngoplasty in patients complaining of unilevel palatal snoring

Conditions: Snoring; Sleep-Disordered Breathing

Summary: the aim of the study is to determine whether there is a statistically significant difference in snoring intensity before and after performing a barbed reposition pharyngoplasty as a single-level snoring procedure. the investigators aim to determine whether this is a valid alternative to the more classical techniques of pharyngoplasty. furthermore, the investigators also wish to map the various postoperative complications and compare them with those of the more conventional techniques. the investigators compare the snoring intensity before surgery with the snoring intensity at 2 weeks (first postoperative control), at 6 weeks (second postoperative control) and at 6 months (third postoperative control). for the evaluation of snoring, the investigators use 4 scales/questionnaires. these questionnaires are currently also used as standard at the outpatient clinic for snoring problems. these 4 scales/questionnaires are completed at every check-up. during the first postoperative check-up, the postoperative side effects are checked (bleeding, infection, readmission, needed consultation with another doctor, date of resumption of work). the investigators also map the pain with a visual analog scale and measure this the day after the operation and let the patient fill it in 3 days, 1 week and 2 weeks after the operation.


Eligibility criteria:
inclusion criteria: * single-level retro-palatal collapse observed during drug-induced sleep endoscopy (dise) exclusion criteria: * osas defined as having an obstructive ahi (oahi) ≥ 30 * obese patients with a body mass index (bmi) ≥ 30 kg/m². * patients with multilevel airway collapse observed during dise * patients younger than 18 years old.

Keywords: pharyngoplasty barbed reposition pharyngoplasty snoring surgery
questionnaire about risk factors of iron deficiency anemia in pregnancy

Conditions: Iron Deficiency Anaemia

Summary: anemia in pregnancy,and especially iron deficiency anemia is both a long standing scholarly interest ,the aim of my research to summarise the risk factors of iron deficiency anemia in pregnancy, especially in egypt as a less developed country,and suggest recommendations about how to prevent it


Eligibility criteria:
inclusion criteria: * women aged 18 years or older with established iron deficiency anemia (hb less than 10) * established intrauterine pregnancy * women want to participate in the study exclusion criteria: * anemia due to other causes * recent blood transfusion in the last 3 months * women with threatened miscarriage * women are known to have pathological blood loss (urinary bleeding or git bleeding) 5- history of haematological disorder 6- women used iron in the past 3 months
cancer diagnoses from exhaled breath with na-nose

Conditions: Volatile Organic Compounds; Cancer; Diagnoses Disease

Summary: early diagnoses of malignant tumors are pivotal for improving their prognoses. the exhaled breath is made up of oxygen, carbon dioxide, nitrogen, water, inert gases and volatile organic compounds (vocs). theoretically, the concentration of vocs in exhalation produced by metabolism in human body is only about nmol/l-pmol/l, which can significantly increase under certain pathological conditions. a series of studies of vocs diagnosing solid tumors the investigators had been conducted in the past decade. it was found that vocs in exhaled breath can not only distinguish different types of tumors, but also can make a clear distinction between different stages. our long-term collaborator, professor hossam haick (israel institute of technology) has developed a nano sensor array, so called na-nose, which can detect vocs of the exhaled breath by binding gases to specific chemiresistors coated with gold nanomaterials. the na-nose has the advantages of low cost, easy to use, good reproducibility and real-time detection for large scale clinical application. this study was to use large clinical samples to validate the diagnostic efficacy of the newly developed nano-nose( sniffphone and breath screener) for malignant tumors .

israel institute of technology provides two type of na-nose. one is breath screener used for large-scale sampling and feature vocs extraction to establish database. the other is called sniff phone aim at clinical real-time vocs detection assisted by software. about 10,000 patients will participate in the subject of breath screener in batches. first, 7000 patients will have a definitive diagnosis and exhaled breath collected. feature vocs of specific tumors will be extracted from these samples and employed to build predictive model by using discriminant factor analysis (dfa). after the predictive model had been completed, 3000 definitively diagnosed patients will participate in validating the specificity and sensitivity of the prediction model. with the assistance of breath screener clinical database and software services, sniff phone is more suitable for clinical real-time detection for its small and convenient design characteristics. at last, breath screener and sniff phone will continue enriching databases and improve diagnosis efficacy in their clinical applications.

Eligibility criteria:
inclusion criteria: * 18-75 years * cancer/benign disease having been diagnosed by pathology * ecog \< 2 exclusion criteria: * concomitant malignancies other than one malignant tumor * diabetes, fatty liver * autoimmune disease * ventilation and transaired function obstacle

Keywords: volatile organic chemicals cancer diagnose disease na-nose breath diagnoses
cardiovascular events for a long time end of covid 19 infection

Conditions: Myocardial Disease

Summary: in the follow-up of partecipants with covid-19 infection, persistence of cardiovascular symptoms is common. studies on the acute phase of covid-19 infection have demonstrated a significant prevalence of acute myocardial damage (15-44%), and imaging studies have confirmed the presence of structural changes in the pericardium and myocardium several months after the acute phase. the aim of the project is to identify the prevalence and characteristics of long-term cardiovascular changes in covid-19 infection.

the study is a continuation of the "cardicovrisk" registry project ("cardiovascular risk and effects ancillary effects of cardiology drug therapy during n-cov-19 infection"), which collected data on alterations cardiovascular changes during the acute phase and shortly after the acute phase. the design of the current study is observational cross-sectional comparison with historical data. the study plans to enroll 240 patients hospitalized during the acute phase of covid-19 infection. enrollment of patients will be carried out in three separate centers. enrolled patients will undergo a baseline assessment by history, objective examination, laboratory tests, ecg, 6-minute walking test and echocardiogram.

Eligibility criteria:
inclusion criteria: * partecipants with previous hospitalization for covid-19 infection confirmed by pharyngeal molecular swab at least 12 months prior to enrollment; * adult partecipants between the ages of 18 and 90 years old; * signature of informed consent; exclusion criteria: * partecipants with poor echocardiographic acoustic window impairing the performance of the examination * partecipants with atrial fibrillation * partecipants with ischemic or nonischemic heart disease with known decreased systolic function of the left ventricle left

Keywords: acute myocardial injury covid-19
the effect of massage and musıc therapy on birth pain, posttravmatic comfort and posttraumatic development

Conditions: Labor Pain; Posttraumatic Growth

Summary: birth pain is the most severe painful experience faced by primiparous people. massage and music therapy reduce tension in the muscles and reduce the feeling of pain. massage and music therapy will be applied to pregnant women. no intervention will be made to a group of pregnant women. numerical pain assessment, post traumatic development scale and birth comfort scale will be used in the research.

birth pain is one of the most severe and difficult to control pains known. non-pharmacological methods used to cope with labor pain are cheap and reliable. massage and music therapy in the first stage of labor are non-pharmacological methods used to reduce labor pain. the purpose of this research; non-pharmacological methods applied to primiparous in labor; the aim of this study is to examine the effects of massage and music therapy on labor pain, postpartum comfort and posttraumatic development. a total of 114 primiparous pregnant women who had a normal delivery expectation and were in the active phase of labor (4-5 cm dilatation) were planned to be included in the study. massage and music therapy will be applied to pregnant women. no intervention will be made to a group of pregnant women. numerical pain assessment, post traumatic development scale and birth comfort scale will be used in the research.

Eligibility criteria:
inclusion criteria: * expectation of normal vaginal delivery * having a term pregnancy * being primiparous - being in the active phase of labor (cervical dilatation 4 cm) * single pregnancy * being in vertex presentation * uncomplicated prenatal process * volunteering to participate in the study * being pregnant without back pain exclusion criteria: * pregnant women whose birth resulted in cesarean section due to failure of labor to progress during labor * pregnant women who did not undergo induction * pregnant women who underwent pharmacological intervention for labor pain
the canadian triage and acuity scale for children; a prospective multi-center evaluation.

Conditions: Triage; Pediatrics

Summary: the aim of this study is to evaluate the validity and the reproducibility of the canadian triage and acuity scale when applied by regular nurses for the triage of children in the emergency department.

the role of triage in the emergency department (ed) is to assign high priority to patients who need urgent care while identifying patients that may be able to wait safely. the canadian triage and acuity scale (ctas) is a triage tool constructed from a consensus of experts that is universally used in canada. until now, there has been no evaluation of the validity of the tool for children in a clinical context. also, its inter-rater reproducibility has not been evaluated. the expected implementation of a revised version of the canadian triage tool in 2008 would be an ideal moment to evaluate its validity and reproducibility. specific objective: 1. to evaluate the validity of the ctas for children visiting a pediatric ed and 2. to measure the inter-rater agreement for nurses using the ctas in these settings.

Eligibility criteria:
inclusion criteria: * every patient younger than 18 years old that presents to the ed will be eligible except for those that need to go directly to the resuscitation room (triage level 1) exclusion criteria: * for ethical reasons, patients that need an immediate treatment will not be recruited in the study. * patients for whom an informed consent could not be obtained (example: insurmountable language barriers) will not be included.

Keywords: triage pediatrics emergency department
evaluate the efficacy and safety of brightening micro-needle patch on facial solar lentigines

Conditions: Solar Lentigines

Summary: this is a single center, randomized, double-blind and placebo controlled clinical study to evaluate the efficacy and safety of brightening microneedle patch on facial solar lentigines. subjects who are 30 to 65-year-old with solar lentigines on their faces will receive brightening microneedle patches on facial solar lentigines once a day for 4 weeks. afterwards, facial images and skin detectors will be used to analysis their skin, according to various skin tone indexes and skin response score sheets.

method: 35 subjects, fitzpatrick skin type ii to iv. each subject has at least two brown solar lentigines on the face, and the two spots are independent, each with a clear boundary and diameter ≥ 0.5 cm. this trial includes 1 screening visit (day -1), wash-out period (2 weeks before the trial), trial period (4 weeks in total), and 3 return visits for detecting (baseline detecting at the end of the wash-out period, the 2nd week and the 4th week of the trial period).

Eligibility criteria:
inclusion criteria 1. men or women between 30 and 65 years old (inclusive); 2. the pi determines the subject's skin type as fitzpatrick skin type ii to iv; 3. the pi's diagnosis is that the subject has at least two brown solar lentigines on the face, and the two spots are independent, each with a clear boundary and diameter ≥ 0.5 cm; 4. the subject can understand and follow the requirements, instructions and restriction of the plan; 5. the subject signs patient consent form in writing. exclusion criteria 1. the pi's diagnosis is that the subject has tissue mutation, inflammation or other lesions on the face; 2. those who have received aggressive facial treatments within the past six months, including laser, ipl, rf (radio frequency), hifu(high-intensity focus ultrasound), or dermal filler injection; 3. those with a history of chronic skin diseases or autoimmune diseases, such as atopic dermatitis, psoriasis, chronic urticaria, vitiligo, rosacea, keloid and so forth; 4. those who have a history of allergies to the product ingredients of the brightening micro-needle patch, the moisturizer or the sunscreen provided by the trial; 5. pregnant or lactating women; 6. those who have used facial blemish-lightening products (such as products claiming to have whitening or blemish-lightening effects), topical or oral whitening drugs within 21 days before entering the trial; 7. those who have smoking habits within 12 months before entering the trial; 8. those who have used any skin medication on the face within 30 days before entering the trial, determined by the pi to have effect on this study; 9. those who have participated in other clinical trials within 30 days before entering the trial; 10. those who are currently undergoing medical treatment and their ability to participate in this trial will be affected; 11. those who the pi considers to be unsuitable to join this trial.

Keywords: solar lentigines micro-needle patch
mindfulness-based relapse prevention for opioid and alcohol use disorders

Conditions: Opioid-use Disorder; Opioid Abuse, in Remission; Alcohol Use Disorder; Alcohol Use Disorder, in Remission

Summary: a randomized controlled trial will examine mindfulness-based relapse prevention (mbrp) program outcomes for 240 individuals who have completed treatment for opioid or alcohol use disorders. mbrp is a group aftercare program that integrates mindfulness skills training with cognitive-behavioral relapse prevention strategies. primary outcomes will include frequency of opioid/alcohol use, craving, withdrawal, and quality of life. secondary outcomes include time to first opioid/alcohol use, adherence to medication-assisted treatment plans, perceived stress, posttraumatic stress symptoms, and chronic pain. we will also examine the following potential moderators of intervention outcomes: comorbid diagnoses, life events history, and mbrp intervention adherence. in addition, we will examine the following mediators of intervention outcome: mindfulness skills, emotion regulation skills, executive functioning skills, savoring, and positive and negative affect.

a randomized controlled trial will examine mindfulness-based relapse prevention (mbrp) program outcomes for 240 individuals who have completed treatment for opioid or alcohol use disorders. participants will be recruited from outpatient medical clinics and substance use recovery centers. they will be assigned to an intervention group (group 1) or waitlist control (group 2), completing assessments at baseline, 8, and 16 weeks. group 1 will receive the intervention in weeks 1-8 and group 2 will receive the intervention in weeks 9-16. mbrp is a group aftercare program that integrates mindfulness skills training with cognitive-behavioral relapse prevention strategies. primary outcomes will include frequency of opioid/alcohol use, craving, withdrawal, and quality of life. secondary outcomes include time to first opioid/alcohol use, adherence to medication-assisted treatment plans, perceived stress, posttraumatic stress symptoms, and chronic pain. we will also examine the following potential moderators of intervention outcomes: comorbid diagnoses, life events history, and mbrp intervention adherence. in addition, we will examine the following mediators of intervention outcome: mindfulness skills, emotion regulation skills, executive functioning skills, savoring, and positive and negative affect.

Eligibility criteria:
inclusion criteria: * over 18 years of age * completed behavioral health treatment for opioid use disorder (oud) or alcohol use disorder (aud) within the previous eight weeks * continues to be followed by a behavioral health provider * meets dsm-5 criteria for oud or aud * english fluency * able to attend intervention sessions exclusion criteria * current psychosis * dementia * moderate to severe traumatic brain injury * pregnancy * active suicidality * persistent antisocial behavior * acute episode of an sud (past two weeks) * persistent self-injury requiring clinical management * already completed or attending a mindfulness-based intervention
third party viral specific t-cells (vsts)

Conditions: Viral Infection; Viral Reactivation; Infection in an Immunocompromised Host

Summary: the purpose of this study is to demonstrate that viral specific t-cells (a type of white blood cell) can be generated from an unrelated donor and given safely to patients with viral infections.

viral reactivation and infection is a major cause of morbidity in immunocompromised patients (including hsct recipients). in this study we will draw blood from unrelated (third party) donors and use the blood to generate viral specific t-cells (vsts) with specificity for epstein-barr virus (ebv), cytomegalovirus (cmv), adenovirus (adv), bk virus (bkv), and jc virus. the vsts will be infused into immunocompromised children with specific viral infections (ebv, cmv, adv, bkv , or jc virus). cells will be selected for infusion based on the recipient's hla type and the viral specificity of the cells.

Eligibility criteria:
inclusion criteria: * immunocompromised patient with evidence of viral infection or reactivation * age \>1 day * recipients who have had a stem cell transplant must be at least 21 days after stem cell infusion * clinical status must allow tapering of steroids to \< 0.5mg/kg prednisone or other steroid equivalent * must be able to receive ctl infusion in cincinnati * informed consent obtained by pi or sub-investigator either in person or by phone exclusion criteria: * active acute gvhd grades ii-iv * uncontrolled bacterial or fungal infection * uncontrolled relapse of malignancy requiring treatment with chemotherapy * infusion of atg or alemtuzumab within 2 weeks of vst infusion * biopsy confirmed acute rejection of solid organ transplant or empiric treatment of suspected but not confirmed acute rejection of solid organ transplant within the last 30 days

Keywords: epstein-barr virus (ebv) adenovirus (adv) cytomegalovirus (cmv) t-cells donor bk virus (bkv)