Kornimate/medical-research-clean huggingface dataset:
angh prospective cohort of mild and severe acute biliary pancreatitis

Conditions: Acute Biliary Pancreatitis

Summary: the main objective of this work is to evaluate the recurrence of biliary episodes before cholecystectomy (hepatic colic, lithiasic migration, cholangitis, cholecystitis, pancreatitis, necrosis infections) in patients with acute biliary pancreatitis of any severity depending on the type of nutrition (oral, enteral or parenteral).

acute pancreatitis (ap) is one of the frequent causes of hospitalization in gastroenterology with an annual incidence of 13-45 cases per 100,000 patients. if we refer to the data in the white paper, hospitalizations for abdominal emergencies, such as pa, take place in at least 60% of cases in general hospital centers (chg). among these ap, approximately 40% of ap are secondary to a biliary lithiasis pathology. the main modalities of the initial management of ap have been the subject of several national and international recommendations and consensuses. although it is well accepted that early refeeding during the first 48 hours reduces the appearance of a systemic inflammatory response syndrome (sirs) or a collection infection, the feeding methods in the event of pancreatitis acute biliary (abp) during the acute phase using the oral route if it is tolerated or the enteral route by nasogastric tube before cholecystectomy remains debated. thus, in case of delayed cholecystectomy after ap, there is no consensus on the feeding methods after the acute phase (oral or enteral) until cholecystectomy nor on the benefit of a prophylactic endoscopic sphincterotomy in the absence of cholangitis.

Eligibility criteria:
inclusion criteria: * adult over 18 years old * affiliated to a social security scheme. * patients with acute biliary pancreatitis exclusion criteria: * patients with chronic pancreatitis * patients with a previous cholecystectomy * patients under guardianship, curatorship or legal protection
the renin-aldosterone axis in postural tachycardia syndrome

Conditions: Postural Orthostatic Tachycardia Syndrome (POTS)

Summary: the purpose of this study is to determine the role of the renin-angiotensin-aldosterone in the pathophysiology of postural tachycardia syndrome, and to provide an insight about the disease process in this disorder.


Eligibility criteria:
inclusion criteria: * diagnosis of postural tachycardia syndrome by the vanderbilt autonomic dysfunction center criteria * age between 18-64 years * male or females are eligible * able and willing to provide informed consent * healthy control subjects with no major medical problem (including postural tachycardia syndrome), free of medications during the study exclusion criteria: * overt cause of postural tachycardia e.g., dehydration * inability to give or withdraw informed consent * pregnancy * hypertension (bp \> 140/90) * significant co-morbid condition * other factors which in the investigator's opinion would prevent the subject from completing the protocol

Keywords: pots orthostatic intolerance
use of interim pet scan to modify therapy in advanced hodgkin's lymphoma in order to improve outcomes

Conditions: Hodgkin's Lymphoma

Summary: the current standard treatment for advanced hodgkin's lymphoma 6-8 cycles of abvd chemotherapy-this cures 70-80% patients. those not cured after 8 cycles of abvd have a poor outcome (\<10% survival). more intensive chemotherapy like escalated beacopp (eb) achieve higher cure rates have more side effects. hence the investigators propose to use interim pet ct scan (done after 2 cycles of abvd) for early identification of poor responders (it is known that those with interim pet positive disease have a cure rate of less than 10-15% if continued with abvd alone) and to use eb selectively in this population in an attempt to improve treatment outcomes - at the same time to limit side effects of therapy. thus, this study is an attempt to improve the outcome in the small subset of poor responders to abvd chemotherapy by the early use of escalated beacopp chemotherapy


Eligibility criteria:
inclusion criteria: * age 12-65 years old * newly diagnosed histology proven patients of advanced hl (stage iib, iii and iv) * patients' performance status ecog 0-2 * normal hematopoetic parameters except if due to marrow involvement by disease (wbc \> 4000/cmm, platelet count \> 100,000/cmm) * no uncontrolled hepatitis b/c infection; and normal lft values with s -bilirubin, sgot and sgpt not more than 2.5 times upper limit of normal (unless initially due to liver involvement by disease) * serum creatinine ≤ 2mg/dl unless elevated due to involvement by disease * cardiovascular/ metabolic: no severe cardiac disease that would limit normal life expectancy or preclude study. lvef at least 50%; controlled blood glucose if diabetic; controlled blood pressure if hypertensive * pulmonary: no severe pulmonary disease that would limit normal life expectancy or preclude study * others: hiv negative status; no prior haematological cancers or chemotherapy or radiation therapy in the past exclusion criteria: * pregnancy * nursing mothers

Keywords: hodgkin's lymphoma pet ct scan escalated beacopp abvd response adapted therapy
task-oriented circuit class training in multiple sclerosis subjects

Conditions: Multiple Sclerosis

Summary: aims of the study: this is a single blind randomized-controlled trial to test the feasibility and the effects of a task oriented training on locomotor function, mobility and balance in multiple sclerosis subjects with moderate gait impairments (edss 4 - 5,5). the control group will not be treated with a specific physical therapy (usual care). subjects and methods: 60 multiple sclerosis patients will be recruited in an outpatient rehabilitation clinic (azienda ospedaliero-universitaria di ferrara). informed consent will be obtained. participants will be randomized to (toct) task-oriented training (experimental group) or usual care (control group) through a randomization stratification approach, according to a block randomization of 6. the experimental group will receive 10 task-oriented training sessions over 2 weeks (5 sessions/week=intensive training). three subjects with a supervisor physiotherapist will take part at the toct. feasibility outcome will be measured with a specific questionnaire. treatment efficacy outcome measures will be clinical test for gait speed (10m walking test), walking endurance (six minute walking test), balance (dynamic gait index) and mobility (time up and go test); a structured interview for the performance(lower extremity mal); self-assessment questionnaire for motor fatigue (fatigue severity scale fss), multiple sclerosis physical and psychological impact (multiple sclerosis impact scale msis-29), walking ability (multiple sclerosis walking scale msws-12). outcome measures will be assessed the week before the treatment (t0), after the treatment (t1) and at 3 months follow-up (t2) to evaluate treatments retention, by a clinician blinded to the treatment.


Eligibility criteria:
inclusion criteria: * males and females, * community dwelling, * age 18 or older * diagnosis of multiple sclerosis in a stable phase, with relapses \> 3 months prior to study enrollment * moderate gait impairments referred to expanded disability status scale (edss) between 4 and 5,5 exclusion criteria: * neurologic conditions in addition to multiple sclerosis that may affect motor function * medical conditions likely to interfere with the ability to safely complete the study * impaired cognitive functioning: mini mental status examination \< 24

Keywords: multiple sclerosis gait rehabilitation
reading analysis in ophthalmologic patients

Conditions: Diabetic Maculopathy; Age Related Macular Degeneration; Glaucoma; Epiretinal Membrane

Summary: investigation of the reading parameters and fixation behavior in patients with different ocular diseases (age-related macular degeneration, glaucoma, diabetic maculopathy, epiretinal membrane) and healthy subjects. in addition, fixation analysis and retinal sensitivity measurements will be done with a microperimeter in each subject.

reading is a complex function. it requires a proper retinal image that is received by the brain. there it is analyzed for letter and word recognition and then the semantics is detected. reading speed slows down when letters are blurred, or do not have enough contrast or luminance or when binocular fusion is hampered. hence, it is obvious that reading ability is reduced in patients with various ocular diseases. especially, pathologies effecting the posterior pole (central and paracentral vision) might impair reading parameters significantly. recently, the eyetracker eyelink 1000 (sr research ltd, canada) became available. it´s application was described previously. briefly, a high-speed infrared camera detects the position of eye (pupil and corneal reflex) and in turn the direction of gaze 500 times per second. during the calibration process the position can be linked to the position on a screen where, for instance, a text or a fixation target can be projected. direction of gaze is recorded during the reading process and the gathered data are analyzed. fixation ability was assessed using eyelink 1000 in patients with age-related macular degeneration. it was shown that fixation is related to visual function. the worse eye showed reduced fixation ability which is improved during binocular fixation. this study investigates reading parameters in patients with various ocular diseases.

Eligibility criteria:
inclusion criteria: * age 21 and older * absence of ocular disease (group 1) * present ocular disease (age-related macular degeneration, glaucoma, diabetic maculopathy, epiretinal membrane/macular hole) as judged by the investigator (group 2 - 5) * maximum of allowed cylinder-power in the spectacles: +1.50d exclusion criteria: * ocular pathologies, that may interfere with study measurements, such as corneal scars * in case of pregnancy (pregnancy test will be taken prior to inclusion into the study in women of reproductive age)

Keywords: diabetic maculopathy age related macular degeneration glaucoma epiretinal membrane reading analysis
bioavailability of lacidipine and telmisartan fixed dose combination tablets relative to separate tablets in healthy subjects

Conditions: Healthy

Summary: study to compare the bioavailability of lacidipine and telmisartan administered as fixed dose combination tablets with the separate telmisartan and lacidipine tablets.


Eligibility criteria:
inclusion criteria: * healthy male and female caucasian subjects as determined by results of screening * age ≥ 18 and ≤ 50 years * broca ≥ - 20 % and ≤ + 20 % * written informed consent in accordance with good clinical practice and local legislation given exclusion criteria: * any finding of the medical examination (including blood pressure, pulse rate and electrocardiogram) deviating from normal and of clinical relevance * gastrointestinal, hepatic, renal, respiratory, cardiovascular, metabolic, immunological or hormonal disorders * surgery of gastrointestinal tract (except appendectomy) * disease of the central nervous system (such as epilepsy) or psychiatric disorders or neurologic disorders * history of orthostatic hypotension, fainting spells or blackouts * chronic or relevant acute infections * history of allergy/hypersensitivity (including drug allergy) which is deemed relevant to the trial as judged by the investigator * intake of drugs with a long half-life (\> 24 hours) (≤ 1 month prior to administration or during the trial, except for oral contraceptives) * use of any drugs which might influence the results of the trial (≤ 10 days prior to administration or during the trial except for oral contraceptives) * participation in another trial with an investigational drug (≤ 2 months prior to administration or during the trial) * smoker (\> 10 cigarettes or \> 3 cigars or \> 3 pipes/day) * inability to refrain from smoking on trial days * alcohol abuse (\> 60 g/day) * blood donation \> 100 ml (≤ 4 weeks prior to administration or during the trial) * excessive physical activities (≤ 10 days prior to administration or during the trial) * any laboratory value outside the reference range of clinical relevance * females only: * no reliable contraception (e.g. oral contraceptives, 3-month injection, intrauterine device, sterilisation) * pregnancy of breast feeding period
exploring clinical study experiences of people with post traumatic stress disorder

Conditions: Post Traumatic Stress Disorder

Summary: participation in post traumatic stress disorder observational study serves as a crucial contribution to advancing medical knowledge and refining the care provided to individuals facing similar health challenges. the primary objective centers on a meticulous examination of trial completion rates and voluntary withdrawals within this distinct patient population.


Eligibility criteria:
inclusion criteria: * diagnosis of post traumatic stress disorder * no prior treatment for post traumatic stress disorder * willing and able to provide informed consent. exclusion criteria: * enrolled in another research study * psychiatric or behavioral illness * inability to provide written informed consent

Keywords: post traumatic stress disorder
the mindfulness-based psycho-educational program focused on emotion regulation strategies

Conditions: Depressive Symptoms; Hope; Difficulties of Emotion Regulation

Summary: in this study, the effects of a mindfulness-based emotion-focused psychoeducation program applied to individuals diagnosed with schizophrenia on emotion regulation difficulties, depressive symptoms, and hope levels will be examined. the research will be carried out as a randomized controlled experimental study with a pre-test-post-test and follow-up design.

schizophrenia is a chronic illness that begins at a young age and leads to impairments in thought, perception, and affect. patients experience a loss of functionality in occupational, social, and personal areas and face emotional challenges such as depression, anxiety, and hopelessness. difficulties in emotion regulation are common among individuals with schizophrenia, making disease management more challenging. emotion regulation refers to the process of recognizing, accepting, and managing emotions using appropriate strategies. literature indicates that difficulties in emotion regulation among individuals with schizophrenia are associated with depression and an increased risk of suicide. mindfulness-based interventions have been found effective in enhancing emotion regulation skills and reducing depressive symptoms, rumination, and hallucinations. this study aims to examine the effects of a mindfulness-based psychoeducation program for individuals diagnosed with schizophrenia on emotion regulation difficulties, depressive symptoms, and levels of hope. the findings are expected to contribute to nurse-led interventions that support the mental health and rehabilitation process of patients.

Eligibility criteria:
inclusion criteria: 1. being diagnosed with schizophrenia according to dsm-5 diagnostic criteria 2. being between 18-65 years old 3. not having any problems with communication 4. being literate 5. being willing to participate in the research 6. having schizophrenia for at least 2 years exclusion criteria: 1. having a neurological disease 2. having a neurocognitive disease 3. having comorbid depression according to dsm-5 diagnostic criteria 4. being a substance abuser 5. having participated in and currently receiving a structured psychotherapeutic intervention program within the last year

Keywords: difficulties of emotion regulation depressive semptoms hope psychiatric nursing
renal denervation in patients after acute coronary syndrome

Conditions: Acute Coronary Syndrome; Arterial Hypertension

Summary: this study is aimed to evaluate the effect of renal denervation to decreasing blood pressure and left ventricle remodeling progression in patients after acute coronary syndrome.


Eligibility criteria:
inclusion criteria: * acute q negative myocardium infarction (during first 14 days) * non stable angina * significant stenosis * bp \> 140/90 torr. during more than 1 year exclusion criteria: * absence of arterial hypertension * thrombolysis during previous 24 hours * indications for cabg
physical activity intervention for patients following lumbar spine surgery

Conditions: Spinal Degenerative Disorder; Spinal Stenosis; Spondylosis

Summary: there is a critical need to target physical activity during postoperative management to optimize long-term recovery after lumbar spine surgery. the overall objective of this study is to conduct a two-group randomized control trial (rct) to examine the feasibility and acceptability of a physical activity telehealth intervention delivered by a physical therapist for improving disability, physical function, pain, and physical activity compared to usual care after spine surgery for a degenerative lumbar condition. the physical activity intervention will include wearable technology and remote physical therapist support to counsel patients on a realistic progression of physical activity (steps per day). the central hypothesis is that this 8-week physical activity intervention performed at two weeks after surgery will be feasible and acceptable. the results of our randomized trial will be used to support a large multi-site clinical trial to test the effectiveness and implementation of this intervention


Eligibility criteria:
inclusion criteria: 1. adults age 18 years or older, of both sexes and all races 2. scheduled for surgical treatment of a lumbar degenerative condition (spinal stenosis, spondylosis with or without myelopathy, and degenerative spondylolisthesis) using laminectomy with or without arthrodesis (i.e., fusion) procedures. 3. participants will be english speaking due to the feasibility of employing study personnel to deliver and assess the study intervention. exclusion criteria: 1. patients having microsurgical techniques as the primary procedure, such as an isolated laminotomy or microdiscectomy will be excluded because individuals having these minimally invasive surgical techniques tend to have a less severe case of lumbar degeneration. 2. patients having surgery for spinal deformity as the primary indication or surgery secondary to pseudarthrosis, trauma, infection, or tumor 3. prior history of lumbar spine surgery 4. presence of back and/or lower extremity pain \< 3 month 5. history of neurological disorder, resulting in moderate to severe movement dysfunction 6. unable to provide stable address and access to a telephone indicating the inability to participate in the intervention.

Keywords: physical activity wearable technology behavioral model funciton disability pain
ciprofol versus propofol for tracheal intubation in icu

Conditions: Emergency Tracheal Intubation in Critically Ill Patients

Summary: the physiological reserves of critically ill patients are relatively low, and the risk of complications related to tracheal intubation in the icu is higher than in the operating room. icu tracheal intubation complications account for approximately 40% -45% of patients, including severe hypotension (10% -43%), severe hypoxemia (9% -25%), and cardiac arrest (2% -3%).ciprofol is a novel 2,6-disubstituted phenol derivative that targeting γ-aminobutyric acid type a (gabaa)-receptor. there are four indications of ciprofol that have been approved by nmpa in recent two years: sedation and anesthesia in non-tracheal intubation procedure/operation, induction and maintenance of general anesthesia, sedation during intensive care, sedation and maintenance in gynecological outpatient surgery. the aim of this study is to compare the effects of propofol and propofol on the circulatory system during tracheal intubation in icu patients, in order to provide a safer induction sedation regimen for emergency tracheal intubation in critically ill patients.


Eligibility criteria:
inclusion criteria: * patients who need to undergo tracheal intubation under sedation after entering the icu; * age range from 18 to 85 years old; * patients or their families have a full understanding of the purpose and significance of this trial, voluntarily participate in this clinical trial, and sign an informed consent form. exclusion criteria: * patients who are allergic to the study drugs, or patients with contraindications to the study drugs; * patients with difficult airways (macocha ≥ 3 points); * patients who require emergency intubation due to sudden cardiac arrest; * patients who require conscious intubation; * patients who can maintain mean arterial pressure (map) above 65mmhg using of one or more vasoactive drugs (equivalent (-)-noradrenaline \> 0.3 μg kg min); * in a state of imminent death; * pregnant and/or lactating women; subject judged by the investigator to have any other factors unsuitable for participation in the study
gonadal tissue cryopreservation for fertility preservation in children with a disorder of sex development

Conditions: DSD, 46,XY; DSD, Ovotesticular; DSD, Sex Chromosome; Disorders of Sex Development; Disorder of Sex Development, 46,XY; Disorder of Sex Development, 46,Xy, Cbx2-Related

Summary: the purpose of this study is to offer gonadal tissue freezing and storage to children who are diagnosed with a disorder of sex development (dsd), who are at increased risk of infertility and certain malignancies (cancer). this study involves the storage of gonadal tissue that is being removed for medical reasons (e.g. prevention of cancer development). it includes the processing and freezing of this gonadal tissue, hopefully for potential future use. the tissue will then be stored long-term until the child wishes to try to use the tissue.

dsd are conditions in which there is incongruence in an individual's chromosomal, gonadal, or phenotypic sex (refers to sex as determined by an individual's internal or external genitalia and expression of secondary sex characteristics).different dsd diagnoses have varying degrees of risk for future malignancy. the treating doctor has or will discuss with the participant the risk of developing cancer due to the child's specific diagnosis, and help decide whether this option is in the best interest of the child, and if there are other options to consider (e.g. leaving gonadal tissue in place and monitoring for development of malignancy). if the participant and family have decided to move forward with removal of gonadal tissue for this clinical reason, they will be asked if they would like to have the child participate in this study. this study seeks to find out if removing gonadal tissue in adolescents and children at risk for losing fertility potential (the ability to have children) and who are scheduled to receive a gonadectomy (removal of gonads) for clinical purposes may preserve, or keep, their ability to have children in the future. additionally, a primary objective of this study is to use donated research tissue to study long-term ways to preserve and restore reproductive function for children diagnosed with a dsd. gonadal tissue cryopreservation in patients diagnosed with a dsd is still considered experimental. there have been no reported live births or pregnancies in this population following gonadal tissue cryopreservation at this time.

Eligibility criteria:
inclusion criteria: * individual \< 30 years of age * children diagnosed with a disorder of sex development who have any risk for malignancy in their gonadal tissue or will have their gonads removed for another clinical indication exclusion criteria: * pregnant children * patients likely to retain inherent fertility and reproductive function * children deemed high risk for perioperative complications * patients 12-18 unable to provide assent (i.e. significant psychiatric problems/cognitive delay) * patients 18 and older unable to provide consent (i.e. significant psychiatric problems/cognitive delay)

Keywords: dsd gtc gonadectomy cryopreservation fertility preservation