Kornimate/medical-research-clean huggingface dataset:
the retrain trial (phase 1)

Conditions: Ischaemic Stroke

Summary: the primary objective is to investigate in stroke patients the impact of geko™ nmes treatment, when used as standard of care for vte prevention, on brain haemodynamics at different stimulation levels and in three different postural positions (supine, semi-supine \[45° seated\] and seated). the aim is to identify the optimal stimulation level and postural position for the maximum response (nmes versus no nmes) with regard to relative total haemoglobin concentration (i.e., the sum of relative deoxyhaemoglobin and oxyhaemoglobin concentrations) using fnirs and eeg.


Eligibility criteria:
inclusion criteria: * adult over 18 * patient with ischaemic stroke diagnosis confirmed by a stroke physician. * no intracerebral haemorrhage as ruled out by computerised tomography (ct) or mri scan. * able to achieve a supine, sitting and semi-sitting position of 45° with the help of another person. * receiving geko™ nmes treatment as standard of care for vte prevention exclusion criteria: * inability to gain consent from the patient. * a transient ischaemic attack (tia). * stroke survivors with ischaemic stroke less than 7 days from onset. * history of epilepsy. * below/above knee amputation. * history of established peripheral neuropathy. * too unwell to participate as judged by physician. * use of any other neuromodulation device that may interact with nmes
comparison of conventional triple therapy versus sequential therapy for h. pylori in peptic ulcer disease: prospective randomized trial

Conditions: Helicobacter Infected Patients

Summary: the purpose of this study is to improve first line helicobacter pylori eradication rate and to compare the sequential versus conventional triple therapy.


Eligibility criteria:
inclusion criteria: * peptic ulcer diseae * two test positive rapid urease test, culture, histology exclusion criteria: * lactating or pregnant * previous stomach surgery * severe underlying disease
study evaluating the safety and efficacy of desvenlafaxine succinate for vasomotor symptoms in menopausal women

Conditions: Vasomotor Symptoms

Summary: the purpose of the study is to evaluate the efficacy and safety of desvenlafaxine succinate (dvs) sustained release (sr), in comparison to placebo for the treatment of vasomotor symptoms (vms) in menopausal women.


Eligibility criteria:
inclusion criteria: * generally healthy, postmenopausal women who seek treatment for hot flushes * body mass index (bmi) less than or equal to 34 kg/m\^2 exclusion criteria: * hypersensitivity to venlafaxine * myocardial infarction an/or unstable angina within 6 months of screening * history of seizure disorder

Keywords: menopause hot flush hot flash desvenlafaxine succinate sustained release
long-term safety and efficacy of furestem-cd inj. in patients with moderately active crohn's disease(cd)

Conditions: Crohn's Disease

Summary: the purpose of this clinical trial is to evaluate long-term safety and efficacy in patients who has history of furestem-cd injection at least once.

this study is an extended study of ksthd_furestem-cd phase 1 / 2a clinical trials in patients with moderate active crohn's disease who had received at least once a furestem-cd injection. the purpose of this clinical trial is to evaluate long-term safety and efficacy in patients for approximately 36 months (144 weeks).

Eligibility criteria:
inclusion criteria: * patients who has history of furestem-cd inj. injection at least once. * patients who understand and voluntarily sign an informed consent form. exclusion criteria: * any other condition which the principle investigator judges would make subject unsuitable for study participation.

Keywords: crohn's disease stem cell therapy inflammatory bowel disease hucb-msc ucb-msc umbilical cord blood rheumatoid arthritis ra stem cell cell therapy furestem mesenchymal stem cell msc
cpet in myocardial ischemia

Conditions: Myocardial Ischemia

Summary: the investigators goal is to determine whether cardiopulmonary exercise testing (cpet) can be utilized in the diagnosis of myocardial ischemia. for the study participants the investigators will recruit patients who have been referred to myocardial perfusion pet/ct scan in kuopio university hospital. the participants will perform the cpet on a cycle ergometer on separate day after the perfusion scan. the investigators will compare the results of the pet/ct scan and cpet and evaluate if the possible perfusion defects detected in pet/ct correlate with the gas exchange parameters in cpet. the patients who receive invasive coronary treatment (coronary bypass surgery or percutaneous coronary intervention) will be invited to perform additional cpet ja pet/ct tests six months after the treatment. the goal will be to determine whether the recovery of myocardial perfusion can be assessed with gas exchange parameters in cpet.


Eligibility criteria:
inclusion criteria: * referral to coronary perfusion pet/ct scan in kuopio university hospital exclusion criteria: * age under 18 years * pregnancy or breastfeeding * handicap * imprisonment * care under forensic psychiatry
telephone support for dementia caregivers

Conditions: Dementia

Summary: caring for a patient with dementia is associated with increased feelings of burden and depression. the proposed study will examine the efficacy of family intervention: telephone tracking - dementia (fitt-dementia), a multi-component, family-based, telephone intervention, as a tool to reduce caregiver stress.

a previous pilot study of this approach showed reduced burden and reaction to memory and behavior problems for dementia caregivers. this study will test the intervention in a larger group of caregivers and have a more detailed analysis of outcomes. the caregiver of a person with dementia will receive telephone support calls. they will receive telephone calls from a trained member of the research team. these calls will occur over a six-month period and will be scheduled at a time that is convenient for the caregiver. they will receive a total of 16 calls over 6 months. during each call, the support person will discuss their current caregiving situation and provide various forms of support.

Eligibility criteria:
inclusion criteria: * 1) diagnosis of dementia; * 2) mild to moderate dementia; * 3) family member or other adult in caregiver role for at least 6 months, and who provides at least 4 hours of supervision or direct assistance per day for the person with dementia; * 4) care recipient lives in the community, including senior/retirement centers, but excluding nursing homes and assisted living centers; and * 5) there is no plan for the care recipient to be placed in long term care or the caregiver to end their role within the next 6 months exclusion criteria: patient: * 1) other major medical condition affecting independent functioning * 2) older than age 90; and * 3) younger than age 50. caregiver: * 1) major acute medical illness; * 2) english not primary language; * 3) cognitive impairment; * 4) no access to a telephone; or * 5) older than age 90.

Keywords: dementia caregivers alzheimer's disease
cognitive impairment in ageing people

Conditions: MCI; Alzheimer Disease; VAD - Vascular Dementia; Cognitive Impairment

Summary: mild cognitive impairment (mci) and neurocognitive disorder such as alzheimer's disease (ad) and vascular dementia (vad) have become common diseases in the elderly. the burden of dementia is rising in china, with major medical, social and economic impacts. to address this important public health problem, cohort study on elderly cognitive disorders should be carry out. the methods of early prevention, early diagnosis and early treatment the cognitive disorders in elderly should be found to reduce the burden of the social and economic issue due to dementia. at present, the international corresponding guidelines have taken gene and brain imaging biomarkers as important indicators of dementia pathogenesis research, accurate diagnosis and targeted intervention. the study will construct a prospective cohort to establish database that provide not only comprehensive epidemiological data on the mci and neurocognitive disorder in ageing people, but also complete the construction of biological samples bank and clinical diagnosis and treatment information database. using the database, the study will identify the conversion rates from mci to dementia and risk factors for the progression from mci to dementia or ad. the study will also apply and develop brain structural and pathological imaging technology to support precision diagnosis of senile cognitive disorders. the study have goals to identify and validate imaging and blood/csf biomarkers for the early detection and tracking of cognitive disorders.


Eligibility criteria:
inclusion criteria: 1. patients over 50 years old. 2. sign informed consent. 3. according to dsm-iv, the diagnostic standard of dementia was not met. 4. the clinical dementia rating (cdr) was 0.5. exclusion criteria: 1. subjects with mental retardation. 2. refuse to have blood sampling, imaging and other examinations. 3. uncooperative subjects that have serious organic diseases, or have a history of mental illness, or have physical disability (including severe aphasia). 4. contraindications of mr scanning. 5. suffering from serious physical or mental illness.
telehealth stretching exercise program for women with fibromyalgia during the covid-19 pandemic

Conditions: Fibromyalgia; Fibromyalgia, Primary

Summary: this study is a randomized, single-blinded, parallel, superiority, controlled trial. the main objective is to verify the effects of a telehealth stretching exercise program on pain, depression, sleep parameters and functionality of women with fibromyalgia, during the covid-19 pandemic. participants will be women with primary fibromyalgia, seen at public and private health services, in the city of pelotas (south of brazil). participants will be recruited through social networks, newspapers and support from the national association of fibromyalgia and correlated diseases (anfibro). eligible participants will be randomized, stratified by age (30 to 45; 46 to 60), and allocated to one of the two groups, experimental or control. the experimental group will receive a telehealth stretching exercise program twice a week (guided by a professional) and counseling guide to stretching exercises with explanatory video regarding the execution of the protocol proposed by the guide. the total duration of exercise program will be 40 minutes (will be 12 exercise, 3 sets of each stretching for 10 seconds, carried out individually by a video call application - whatsapp). the control group will receive only counseling guide to stretching exercises with explanatory video regarding the execution of the protocol. both interventions will last 12 weeks, with outcomes evaluations in three moments: baseline (week 0), midpoint (week 6) and after the intervention (week 13). the following outcomes will be evaluated: generalized index of pain, fatigue and severity of symptoms, depression, level of physical activity, functionality, quality of life and sleep. all outcomes will be evaluated by questionnaires self-completed, that will be answered on google docs by video call, with exception of functional test that will be applied by video call. the study's hypothesis consists of improving outcomes for both groups, but with superiority for the experimental group.


Eligibility criteria:
inclusion criteria: * women between 30 and 60 years of age; * diagnosis of fibromyalgia (according medical confirmation) at least three months before eligibility; * inactive for at least three months; * inability or unwillingness to give informed consent for participation and to complete the questionnaires; * consent to participate in the study regardless of the allocation group. exclusion criteria: * presence of another associated rheumatic pathology (secondary fibromyalgia); * uncontrolled systemic disease; * being under physiotherapeutic treatment; * lack of internet access.

Keywords: stretching exercise telehealth
evaluation of an organized consultation "return home" of patients with a cancer (credo)

Conditions: METASTATIC CANCER

Summary: prospective, open label, randomized and multicentric study evaluating the efficacy of an organized consultation "return home" compared to a current standard of care in patient hospitalized due to metastatic solid tumor cancer. subject will be randomized (1:1) as described below : • arm a (standard) : current standard of care ; connection documentation faxed to gp ( general practitioner) on the day of patient's discharge arm b (experimental) : credo standard of care, organized consultation "return home" between patient, gp desc (diploma of complementary specialized study) and patient's referent gp


Eligibility criteria:
inclusion criteria: 1. age \> or = 18 years old 2. subject hospitalized in an oncology dedicated center for administration of the first chemotherapy cycle. 3. subject with metastatic solid tumor whatever the organ 4. subject planned to be discharged home after chemotherapy administration 5. affiliated to the french social security system. 6. subjects must provide written informed consent prior to any study-specific procedure or assessment exclusion criteria: 1. subject included in another trial evaluating the pathways care 2. pregnant or breastfeedings women 3. subject law protected
scientific information and beliefs about psychological therapy

Conditions: Anxiety

Summary: the success of psychological therapy can be impacted by patients' beliefs, such as their belief in their own ability to complete therapy and their belief that therapy will work. the goal of this clinical trial is to learn whether and when scientific information about distress and coping can affect beliefs about psychological therapy in adults who experience anxiety. this study will compare two different types of scientific information in a one-hour study. participants will view educational videos for 30 minutes and complete surveys, including quiz questions about the videos and surveys about their beliefs about psychological therapy.


Eligibility criteria:
inclusion criteria: * probable anxiety disorder based on the overall anxiety severity and impairment scale (oasis) score * fluent in english * willingness and ability to comply with the protocol * age 18-80 * the ability to enroll in the study through prolific.com exclusion criteria: * having previously seen the study's videos

Keywords: beliefs mindsets exposure therapy neuroscience education psycho-education neuro-education
shanghai high myopia study for adults

Conditions: High Myopia

Summary: high myopia retinopathy has become the first cause of irreversible blindness and severe visual impairment in chinese adults, in order to avoid the blind and visual impairment caused by high myopia retinopathy, it is very necessary to research the mechanism of early visual impairment to prevent and control damages. our recent research found that the decreasing of macular retina vascular density and subfoveal choroidal thickness, the increasing of beta zone area in optic atrophy and the rising of glycosylated hemoglobin in high myopia patients were significantly related to visual impairment, which suggested that the source of visual impairment was the abnormal structure changes surrounding optic and fovea, but so far there is no related study. we will conduct a 5 years prospective cohort study in the population of 2420 high myopia and controls which have established in college student population, working population and aged more than 50 years old population, using the latest oct-a and ss-oct to measure macular retina vascular density, subfoveal choroidal thickness, beta zone area in optic atrophy, combined with the semiparametric mixed effects model, we will analysis the prediction index between fundus structure parameters, blood biochemical index and individual characteristics prediction to explore the public health management mode of early prevention and treatment during high myopia population.


Eligibility criteria:
inclusion criteria: * ≥18 years old; spherical equivalent refraction ≤-6.00d; exclusion criteria: * a history of ocular or systemic diseases including congenital cataract and glaucoma; previous intraocular or refractive surgery;other evidence of retinal pathology

Keywords: high myopia, fundus structure, early visual impairment
the effect of bicarbonate profiling in dialysis fluid on phosphate removal during hemodialysis and blood ph

Conditions: Phosphorus Metabolism Disorders; Acid-Base Balance Disorder

Summary: hyperphosphatemia is still an unresolved problem among hemodialysis patients and significantly increases the risk of death from cardiovascular diseases. research to date has not answered the question of whether dialysate bicarbonate concentration profiling can improve phosphate removal and its concentration without negative impact on the acid-base balance. this study addressed this issue. twenty stable hemodialysis patients will enroll to a four-week study during which different dialysate bicarbonate concentration profiles will be used each week. each patient will undergo the following profiles (one-week periods): treatment a - stable dialysate bicarbonate concentration dbic 35 mmol/l during the whole hd session, treatment b - dbic 35 mmol/l for the first two hours and dbic 30 mmol/l for the next two hours and treatment c - the opposite mid-hd change dbic from 30 to 35 mmol/l and one week wash-out period between treatment b and c. we will collect blood samples each hour during the session and one hour after hd completion.


Eligibility criteria:
inclusion criteria: * stable general condition * hemodialysis more than 3 months * dialysis 3 times a week/ 4 hours +/- 20 minutes * dialysis with arterio-venous fistulas * bicarbonate titer before hemodialysis 22-24 mmol/l exclusion criteria: * diabetes mellitus * cachexia * inflamation processes * usage of sevelamer last month * utrafiltration during dialysis more than 2500 ml

Keywords: phosphorus hemodialysis bicarbonate acidosis alkalosis
a clinical trial to evaluate the efficacy and safety of hl301 versus placebo in acute bronchitis patients

Conditions: Acute Bronchitis

Summary: a multicenter, randomized, double-blinded, placebo-controlled, parallel, phase ii clinical trial to evaluate the efficacy and safety of hl301 versus placebo in acute bronchitis patients. endpoint: bss, the improvement and improvement rate of the tester for the treatment response, the satisfaction of the subject, total usage of acetaminophen


Eligibility criteria:
inclusion criteria: 1. both gender, 19 years ≤ age ≤ 80 years 2. (bronchitis severity score)\* ≥ 5point at visit 2 (randomized visit) 3. acute bronchitis within 48hr based on visit 2 (randomized visit) 4. those who can comply with the requirements of clinical trials 5. written consent voluntarily to participate in this clinical trial exclusion criteria: 1. patients with respiratory and systemic infections requiring systemic antibiotic therapy 2. patients with bleeding tendency 3. patients who investigators determines to severe respiratory disease that would interfere with study assessment 4. patients who were treated with oral systemic adrenocortical hormone or immunosuppressive drug within 4 weeks prior to visit 2 5. patients who were treated with oral antihistamines, ace suppressive. or systemic/inhalative glucocorticosteroid within 2 weeks prior to visit 2

Keywords: acute bronchitis
multinight cpap for sleep apnea patients

Conditions: Sleep Apnea; Sleep Disordered Breathing

Summary: obstructive sleep apnea (osa) is a prevalent disorders characterized by intermittent obstructions of the upper airway during sleep. continuous positive airway pressure (cpap) has been shown to be the most efficacious treatment for osa. it consists of a small device that provides positive airway pressure delivered by a mask attached to the patients nose/mouth.

the primary purpose of this study is to evaluate the multinight (mnt) algorithm on patients with obstructive sleep apnea (osa) over 45 nights while using a cpap machine at home. the researchers are evaluating the performance of the existing algorithm as well as capturing the data to make enhancements. two main stages of this algorithm will be assessed: i. fast track (ft) stage. in the ft stage the aim is to assess if the algorithm reliably and timely reaches approximate therapeutic pressure levels. ii. slow titration (st). in the slow titration stage the aim is to assess if data samples have been appropriately collected in a pressure range so that the therapeutic pressure can be inferred according to the algorithm proposed.

Eligibility criteria:
inclusion criteria: * \> 18 years of age * no contradictions to continuous positive airway pressure (cpap) * able to provide consent exclusion criteria: ° vulnerable subjects

Keywords: sleep disordered breathing sleep apnea
evaluation of pulse fibre supplementation on obesity and the metabolic syndrome

Conditions: Obesity

Summary: the recent dramatic increase in obesity has been linked to a reduction of dietary fibre intake. we hypothesized that supplementing the diet of overweight and obesity adults with pulse fibre will improve their metabolic status, chiefly defined as greater weight loss. other metabolic health improvements may include improved glucose control and reduced inflammatory markers.

the main objective of our study is to assess the effects of pulse fibre supplementation on weight loss in an overweight and obese adult population. primary objective - to determine the effects of a 12 week intake of 15g/day of pea hull fibre on weight loss supported by body composition measures. secondary objective - to measure glucose control and appetite regulation in overweight and obese adults consuming 15g/day of pea hull fibre compared to a placebo control with the use of plasma hba1c and an oral glucose tolerance test (ogtt). tertiary objective - to examine mechanisms of action of pulse fibre supplementation by determining the impact of pulse fibre supplementation on gut microbiota, serum metabolomics and fecal short-chain fatty acid and bile acid concentrations.

Eligibility criteria:
inclusion criteria: * males and females * age 18 - 70 years * bmi 25 - 38 kg/m-2 * stable body weight for at least 3 months prior to the study exclusion criteria: * concomitant use of any weight loss medication, diet or exercise regime * use of corticosteroids, anti-depressants, anti-epileptic medications, lipid lowering medication, diabetes medications * previous bariatric or other intestinal surgeries * pregnancy or lactation * weight loss \> 3 kg within preceding 3 months to enrollment * use of bulk laxatives or probiotics/prebiotics supplements * antibiotic use in the past month * clinically significant cardiovascular or respiratory or liver disease

Keywords: dietary intervention dietary fibre obesity metabolic syndrome weight loss glucose regulation pulse fibre