Kornimate/medical-research-clean huggingface dataset:
brief online personalised feedback intervention for gambling harm

Conditions: Problem Gambling

Summary: purpose and significance a brief self-directed online personalised feedback intervention was developed for the uk context designed to prevent, reduce, and address gambling harm. the intervention, which also comes in a paper format, comprises of normative feedback and personalised information on the risk of gambling above lower-risk gambling guidelines. the content is based on recent work adapting the canadian lower-risk gambling guidelines to the uk context. the purpose of this exploratory research is to conduct the first randomised controlled trial of this intervention. further, given the increased prevalence of online gambling, the project will target this at-risk population. rationale this project will generate participant feedback on the intervention important to improve its utility. the project will also produce publishable findings on the intervention's efficacy. this evaluation provides a necessary first step towards the wide-spread implementation of this free-of-charge intervention in the uk. methodology first, using methods developed in our previous research, we will rapidly recruit 926 online gambling participants with moderate or problem gambling from an existing online panel of uk residents. these participants will be randomised to receive the self-directed online intervention or assigned to a no intervention control group. participants will be followed-up up at one- and three-months to provide detailed feedback on their impressions of the intervention (and what further modifications are needed) and to assess the short-term impact of the intervention on gambling frequency and harm. potential implications of the proposed research the intervention can be accessed at any time of the day and allow the delivery of help without requiring face-to-face contact. online interventions also have the potential to promote reductions in social inequalities through reducing barriers to accessible care. at present, there appears to be no uk online at-risk gambling intervention that is publicly available.


Eligibility criteria:
inclusion criteria: * problem gambling severity index score of 3 or more * willingness to complete 1 and 3-month follow-up surveys exclusion criteria * do not live in the united kingdom * incorrectly answer attention check question on baseline survey * do not endorse that they answered all questions truthfully on the baseline survey
deporra-coprost: assessment of new fluorescence imagery techniques using prostate chips from transurethral resections

Conditions: Prostate Cancer

Summary: the aim of this study is divided in 4 different steps: * the first step has two different purpose: assess the impact of the storage medium of fresh prostatic chips on fluorescence signal and adjust the entire chain (immunolabelling,counter-stain and imaging), * the second step is the adaptation of immunolabelling protocol on histopathology slides, using fresh prostatic tissue, * the third step is to validate the use of: 1. the medical device created by the femto-st institute use for the detection of fluorescence signal on fresh tissue, 2. the light-ct scanner use for tissue structural observation. * the four step is to check the preservation of morphological structure of tissue under the effect of laser excitation from the medical device.


Eligibility criteria:
inclusion criteria: * male patient over 18 years old. * patient scheduled for trans-urethral resection of prostate with: 1. prostate specific antigen (psa) blood level ≤ 4 ng/ml and age \> 80 years old 2. a suspected prostate cancer after a digital rectal examination (dre) and a psa blood level \> 50 ng/ml or an existing prostate cancer * patient affiliated to social security or beneficiary of such a regime. exclusion criteria: * protected patient referred to in articles l1121-6 to l1121-8 of the code of public health

Keywords: prostate cancer medical device fluorescence
painful procedures in the emergency department: a distraction intervention (3-5 year olds)

Conditions: Anxiety; Pain

Summary: this study is designed to assess the effectiveness of the video-based intervention over and above current standard practice for pain control in the pediatric emergency department (ed). this is a single-center trial based at the iwk health centre. the primary outcome will be based on the child-adult medical procedures interaction scale (campis) coding of the video-taped pain response of the research participants (3-5 years old).

the purpose of this study is to determine if the pain and anxiety that children experience when they have venipuncture procedures performed can be reduced by a video-based distraction and coping strategy intervention. an instructional video has been designed to educate parents and children about what is going to happen during the venipuncture procedure, to teach coping skills that can be used before and during the painful procedure, and to provide distraction during the procedure by using an entertaining video segment. approximately 168 children (3-5 years of age) who are seen in the iwk ed requiring venipunctures for blood collection or iv starts will be randomized. parent and child training in distraction and coping strategies will be provided by means of a self-administered video-delivery via a portable dvd player. fifty percent of the eligible participants will receive the distraction and coping strategies intervention and 50% will receive the standard medical care provided by the iwk ed. those receiving standard care will be evaluated for outcome results and then be compared to the intervention group. it is expected that children who receive the intervention will report less pain and anxiety associated with venipunctures than those who receive standard care.

Eligibility criteria:
inclusion criteria: participants will be eligible for this study if they: * are between 3-5 years of age * are presenting in the iwk emergency department requiring venipuncture for blood collection or intravenous (iv) initiation. * are able to read and speak english * provide written parental authorization exclusion criteria: participants will be excluded for this study if they: * are in critical condition as determined by ed staff * are in significant pain for other reasons other than the venipuncture * have severe cognitive delay * require sedation for the venipuncture as determined by the ed staff

Keywords: pediatric anxiety pediatric pain emergency room procedures
a study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of pf-06882961 in japanese adults with type 2 diabetes mellitus

Conditions: Type 2 Diabetes Mellitus

Summary: this is a phase 1, randomized, double blind (sponsor open), parallel, placebo controlled, twice daily oral dosing study of pf 06882961 in adult japanese participants with t2dm inadequately controlled on diet and exercise alone.


Eligibility criteria:
inclusion criteria: * patients with t2dm who are treated with diet and exercise * hba1c greater than or equal to 7% and less than or equal to 10.5% * total body weight \>50 kg (110 lb) with bmi 22.5 to 45.4 kg/m\^2 exclusion criteria: * any condition possibly affecting drug absorption * diagnosis of type 1 diabetes * history of myocardial infarction, unstable angina, arterial revascularization, stroke, heart failure, or transient ischemic attack within 6 months of screening * any malignancy not considered cured * personal or family history of mtc or men2, or participants with suspected mtc * acute pancreatitis or history of chronic pancreatitis * symptomatic gallbladder disease * known medical history of active proliferative retinopathy and/or macular edema * known history of hiv, hepatitis b, hepatitis c or syphilis * supine blood pressure greater than or equal to 160 mmhg (systolic) or greater than or equal to 100 mmhg (diastolic) * clinically relevant ecg abnormalities * positive urine drug test
ketoprofen with or without vaginal isonicotinic acid hydrazide prior to hysterosalpingography

Conditions: Infertility, Female

Summary: the aim of our study is to determine the efficacy of ketoprofen with or without vaginal isonicotinic acid hydrazide on the pain scores during hsg.

hysterosalpingography can cause pain and discomfort in several ways: use of the tenaculum to grasp the cervix and straighten the uterus for proper insertion; trans-cervical actions including measuring uterine depth, inserting the cannula; and injection of the dye

Eligibility criteria:
inclusion criteria: * any patient came for hysterosalpingography exclusion criteria: * any patient has contraindication to hsg
maximizing patient goal attainment

Conditions: Knee Osteoarthritis; Knee Injuries; Knee Pain Chronic; Knee Injuries and Disorders

Summary: to evaluate the effectiveness of the goal development intervention in guiding individual patients through the identification of high quality, specific, measurable, relevant and time-bound goal for treatment.


Eligibility criteria:
inclusion criteria: * individuals 21 years of age or older * new patients or existing patients with a new problem that are scheduled to see an orthopaedic surgeon in the hip and knee arthroplasty service for a knee consult. exclusion criteria: * individuals who are unable to consent or complete surveys without assistance * non-english speaking * patients who are less than 12 months from surgery on the knee they are being evaluated for, less than 6 months from surgery on the spine, or less than 3 months from another knee/hip surgery

Keywords: orthopaedic knee patient goals
timing for rectal surgery after chemoradiotherapy

Conditions: Rectal Cancer

Summary: the aim of this study is to determine whether greater rectal cancer downstaging and regression occurs when surgery is delayed to 12 weeks after completion of radiotherapy/chemotherapy compared to 8 weeks. hypothesis: greater down-staging and tumor regression is observed when surgery is delayed to 12 weeks after completion of chemoradiotherapy compared to 8 weeks.


Eligibility criteria:
inclusion criteria: * over 18 years old * eastern cooperative oncology group (ecog) 0-1, * american society of anesthesiologists' (asa) score i-iii * histological confirmation of adenocarcinoma of rectum * t3 or t4 n0, t any n positive cancer on mri, without metastasis on ct scan * undergoing preoperative radiotherapy/ chemotherapy * curative total mesorectal excision intended * written informed consent * patients undergoing preoperative radiotherapy should not be excluded exclusion criteria: * patients with distant metastasis * t1 or t2, n0 cancer on mri * rectal cancer 12 cm above the dentate line * contraindications to mri * patients previously treated of pelvic organ cancer * medical or psychiatric conditions that compromise the patients ability to give informed consent

Keywords: rectal cancer chemoradiotherapy surgery
acute normovolemic hemodilution on serum-creatinine concentration in cardiac surgery

Conditions: Mitral Regurgitation; Mitral Stenosis; Tricuspid Regurgitation

Summary: serum-creatinine level (s-cr) is an important factor for predicting perioperative patient's outcome regarding acute kidney injury. although cardiopulmonary bypass (cpb), an essential procedure for cardiac surgery, dilutes patient's blood components, possible impact of applying acute normovolemic hemodilution (anh) and cpb on s-cr has not been well investigated. in patients undergoing cardiac surgery employing moderate hypothermic cpb (age 20-71 years, n=32), anh will be randomly applied to 15 patients (group-anh) but not in 17 patients (group-c) before initiating cpb. for anh procedure consisting of 5 ml/kg of blood salvage and administering 5 ml/kg of balanced hydroxyethyl starch (hes) 130/0.4 for 15 min will be started at 30 min after anesthesia induction and before cpb application for surgery. in both groups, moderate hypothermic cpb will be initiated by using 1600-1800 ml of bloodless priming solution. the changes of hematocrit (hct), na+, k+, hco3-, ca2+, osmolarity, s-cr will be determined before anh (t1), after the first anh of 2.5 ml/kg (t2), and after the second anh of 2.5 ml/kg (t3), 30 sec and 60 sec after the initiation of cpb (t4, t5), immediately and 1 hour after the weaning from cpb (t6, t7) and at the end of surgery (t8). s-cr will be determined by using a point-of-care test device (statsensor™ creatinine, nova biomedical, usa).


Eligibility criteria:
inclusion criteria: * patients undergoing cardiac surgery with cardiopulmonary bypass who signed written informed consent exclusion criteria: * preoperative renal failure requiring reran replacement therapy * preoperative liver disease * preoperative low cardiac output (ef \< 50%) * preoperative iabp application, atrial fibrillation, pacemaker, * contraindication for applying tee * intraoperative withdrawal

Keywords: cardiac surgery acute normovolemic hemodilution
expandability of aging adipose tissue

Conditions: Aging; Obesity

Summary: the purpose of this pilot study is to determine whether adipose tissue loses some of its ability to expand in response to overfeeding in older compared to younger men. the investigators hypothesize that the adipose tissue response to overfeeding may be weakened in older when compared to younger men, thereby leading to worsened ectopic storage depots for older men.

this pilot study will begin to address whether adipose tissue biology changes with advancing age. specifically, we will test whether adipose tissue loses some of its ability to expand in response to overfeeding in older compared to younger men. to test this possibility the investigators will recruit overweight and mildly obese older (age 55-75y) and younger (age 25-40y) men and collect adipose tissue biopsies before and after 7 days of overfeeding. the investigators will test how well the cells in adipose tissue expand in response to overfeeding and whether this differs between younger and older men.

Eligibility criteria:
inclusion criteria: * men * aged 25-40y or 55-75y * bmi 28-35 kg/m2 * weight stable (±2kg over past 3 mo) * sedentary to moderately active (\ 20min) * non-smokers (never used or quit \>7yrs prior) exclusion criteria: * women * currently using hormones, glucose or lipid lowering medication * engaged in exercise or diet program * currently gaining or losing weight or using weight loss drugs * diabetes mellitus (diagnosis, treatment, fbg ≥126 mg/dl) * uncontrolled metabolic disorders (e.g., thyroid)

Keywords: adipose tissue overfeeding
efficacy of aleo vera use in prevention and treatment of chemotherapy-induced oral mucositis in a group of egyptian children with acute leukemia

Conditions: Oral Mucositis

Summary: evaluatation the efficacy of aleovera in prevention and treatment of chemotherapy-induced oral mucositis in children suffering from acute leukemia in terms of appearance and severity


Eligibility criteria:
inclusion criteria 1. patients suffering from acute leukemia( acute lymphocytic leukemia ). 2. patients scheduled for chemotherapy treatment. 3. patients who range from 3 to 13 years old. 4. patients with no history of any chemotherapy or radiotherapy. 5 -both sexes exclusion criteria 1-patients scheduled for radiotherapy treatment . 2-existence of any signs or symptoms of oral mucositis. 3-unwilling to participation in the study 4- patients with any other systemic diseases or other neoplasms.
the performance of the appy1 test in the evaluation of possible acute appendicitis

Conditions: Acute Appendicitis

Summary: this study will consist of a brief interaction with the subject or parent or guardian to obtain consent, collect a blood sample, medical history, and physical examination of those who meet the inclusion criteria. the blood sample will be tested for the wbc value, as well as processed into plasma in order to compute the appy1 test result, which is based on a combination of the wbc value and the plasma mrp 8/14 and crp concentrations received from the appy1 test cassette. there will be a 2-week (14 days +/- 3) follow-up telephone call for those subjects that were discharged from the ed without an appendectomy or diagnosis of acute appendicitis. use of the appy1 test to help identify low risk patients could significantly reduce the use of ct scans in diagnosis of aa, thereby reducing the exposure to ionizing radiation in children, adolescents, and young adults.


Eligibility criteria:
inclusion criteria: * 2 to 20 years old (up until the 21st birthday), * right lower quadrant or poorly localized abdominal pain, or tenderness that includes the right lower quadrant, and/or other features including, but not limited to, nausea, vomiting, and/or anorexia, requiring acute appendicitis to be added to the differential, * onset of abdominal pain within 72 hours or less, * patients of either gender may participate and, * patient or accompanying parent or guardian is able to provide informed consent. exclusion criteria: * history includes prior appendectomy, * subjects whose presentation history and physical examination place them at such high risk of acute appendicitis that it would be clinically reasonable to proceed with exploratory laparotomy and/or appendectomy without advanced imaging, * treatment with any immunosuppressive medication or chemotherapeutic agents within 28 days, or systemic steroids (oral or intravenous) within 14 days, * history of end-stage, metastatic cancer or an active immune disorder, * history includes abdominal trauma or invasive abdominal procedures/surgery within the previous two weeks, * patients who have received diagnostic imaging (ct, mri, or us) for abdominal pain in the previous two weeks, * patients with report of abdominal pain greater than 72 hours, * history of active bleeding disorder, which may complicate phlebotomy or placement of peripheral iv catheter, * participation in a research study within the previous 30 days, * prisoners of an adult or juvenile detention center, and * subject, parent or guardian unable to provide informed consent.
study to evaluate the safety and pharmacokinetics of efmarodocokin alfa in combination with standard of care in participants undergoing allogeneic hematopoietic stem cell transplantation

Conditions: Acute Graft-versus-host Disease

Summary: this is a phase ib, open-label, multicenter, dose-escalation study to evaluate the safety, tolerability, and pharmacokinetics of efmarodocokin alfa and to make a preliminary assessment of activity of efmarodocokin alfa in combination with standard-of-care (soc) in the prevention of acute graft-versus-host disease (agvhd) in participants undergoing allogeneic hematopoietic stem cell transplantation (hsct).


Eligibility criteria:
inclusion criteria: * eligible for hematopoietic stem cell transplantation (hsct) * donor meeting human leukocyte antigen (hla) matching criteria of hla-matched related or hla-matched unrelated (hla-a, hla-b, hla-c, and hla-drb1, eight out of eight) from either peripheral blood or bone marrow stem cells and meeting donor-eligibility criteria as outlined by the u.s. food and drug administration (fda) in 21 cfr 1271 (including screening for zika and sars-cov-2 exposure or infection) * planned hla (hla-a, hla-b, hla-c, and hla-drb1)-matched (eight out of eight) related or planned hla-matched (eight out of eight) unrelated hsct, from either peripheral blood or bone marrow stem cells, for patients with acute myeloid leukemia (aml) or acute lymphocytic leukemia (all) in first complete remission (per institutional criteria) or patients with intermediate or high-risk myelodysplastic syndrome (mds) * planned myeloablative conditioning regimen per institutional guidelines * planned agvhd prophylaxis consisting of tacrolimus and methotrexate; in cases of tacrolimus intolerance, cyclosporine or sirolimus may be used as a substitute exclusion criteria: * prior receipt of autologous or allogeneic hsct * diagnosis of myelofibrosis or myelodysplastic/myeloproliferative overlap syndrome * treatment with investigational biologic or non-biologic therapy within 5 drug elimination half-lives (or within 90 days or 30 days, respectively, if half-life is unknown) prior to initiation of study drug * positive hepatitis b virus (hbv) or hepatitis c virus (hcv) serologies * history of grade \>1 cervical intraepithelial neoplasia * a marked baseline prolongation of qt/qtc interval * risk factors for torsades de pointes * pregnant or breastfeeding * any serious medical condition or abnormality in clinical laboratory tests that, in the investigator's judgment, precludes the patient's safe participation in and completion of the study
the effect of occupational therapy on subthreshold attention deficit hyperactivity disorder

Conditions: Attention Deficit and Disruptive Behavior Disorders

Summary: the purpose of this study is to investigate the effectiveness of occupational therapy in subthreshold attention deficit hyperactivity disorder.

subthreshold attention deficit hyperactivity disorder may occur in a subset of children who are possibly more sensitive to their environment. therefore, it is very important to target the elimination of symptoms with appropriate preventive therapies before this disorder occurs. one of the promising preventive therapy option may be occupational therapy. attention deficit hyperactivity disorder can have a negative impact on occupational performance such as: activities of daily living, education, resting, sleeping, playing and social participation. occupational therapists are able to provide interventions to improve engagement in daily activities on social skills, play, executive functioning, impulsivity, inattention, and motor coordination. although the guidelines about the treatment of adhd are primarily medically and psychologically based, certain treatment components are useful for occupational therapy practice; for example, behavioural management of the child and psychoeducational programmes for families. however, treatment recommendations for subthreshold adhd cases or the population at risk are limited. this study investigates the effectiveness of occupational therapy in subthreshold attention deficit hyperactivity disorder.

Eligibility criteria:
inclusion criteria: * subthreshold attention deficit hyperactivity disorder exclusion criteria: * attention deficit hyperactivity disorder