Kornimate/medical-research-clean huggingface dataset:
a clinical safety and efficacy comparison of nevanac 0.1% to vehicle after cataract surgery in diabetic retinopathy patients

Conditions: Macular Edema

Summary: the purpose of this study is to determine whether nepafenac is safe and effective for reducing the incidence of macular edema following cataract surgery in diabetic retinopathy patients.


Eligibility criteria:
inclusion criteria: * patients with non-proliferative diabetic retinopathy (mild, moderate or severe) and planned cataract extraction by phacoemulsification. * other protocol-defined inclusion criteria may apply. exclusion criteria: * central subfiled macular thickness greater than or equal to 250 microns * cme in either eye. * other protocol-defined exclusion criteria may apply.

Keywords: diabetic retinopathy cystoid macular edema;
modulation of frontal eeg alpha oscillations during maintenance and emergence phases of general anesthesia

Conditions: Postoperative Delirium

Summary: the investigators intend to recruit 600 participants to see if alpha power during anesthesia is influenced by analgesic medication and associated with a reduction of delirium following surgery.

postoperative delirium may manifest in the immediate post-anesthesia care period. such episodes appear to be predictive of further episodes of inpatient delirium and associated adverse outcomes. intraoperative monitoring of frontal electroencephalogram (eeg) has been associated with postoperative delirium and poor outcomes. however, the efficacy of titrating anesthesia medication to proprietary index targets for preventing delirium remains contentious. the investigators aim to assess the efficacy of two pharmacologic strategies which could prevent post-anesthesia care unit (pacu) delirium (1) maximization of intraoperative alpha power during maintenance and (2) switching anesthesia regimes during the emergence phases of anesthesia.

Eligibility criteria:
inclusion criteria: * adults aged 60 years or over * has capacity to provide informed consent * undergoing elective non-cardiac surgery, which does not involve the head or neck, with planned volatile-based general anesthesia of expected duration of at least 2 hours exclusion criteria: * chronic pain with opioid requirement or concurrent use of enzyme inducers, e.g. carbamazepine, phenytoin, * illicit substance use or excessive alcohol intake * refusal by patient or case anesthesiologist responsible for patient's care

Keywords: eeg general anesthesia
investigation of the effects of bapne and qi gong exercises on balance and quality of life in individuals over 60

Conditions: Biomechanics, Anatomy, Psychology, Neuroscience, Ethnomusicology Method; qi Gong; Quality of Life; Balance

Summary: geriatric problems develop with aging in individuals over 60 years of age. these problems include muscle weakness, balance disorders and changes in quality of life. the aim of our study is to examine the effects of bapne (bme) and qi gong (qg) exercises on balance and quality of life in individuals over the age of 60. in this study, parameters such as fall risk, muscle testing, balance, functional capacity, cognitive functions, depression and sleep quality were evaluated. 56 participants were included in the study. all cases were evaluated for the first time before they were included in the study. in the initial evaluation, itaki fall risk questionnaire, 6-minute walk test, berg balance scale, pittsburg sleep quality index, world health organization quality of life scale elderly module, beck depression scale, mini mental state test, object flipping test, word fluency test, stroop test, muscle strength with jtech brand myometer and balance on libra balance board were measured. participants were divided into groups of 2-6 people, and second assessments were made after a total of 20 sessions of bme exercises for 6 weeks. after a 2-week rest period, the participants were included in the third assessment and included a total of 20 sessions of qg exercise over 6 weeks. at the end of 6 weeks, the fourth evaluation was made.


Eligibility criteria:
inclusion criteria: * be 60 years old or older * able to walk independently * volunteering to exercise at least 3 days a week within the scope of the research exclusion criteria: * having an orthopedic or surgical problem that prevents walking or exercising * having any neurological problems * the presence of a pulmonary, cardiac, or systemic disease that would constitute a contraindication for exercise.
cardiac output and other hemodynamic changes with prone position in cervical myelopathy patients undergoing surgery

Conditions: Hemodynamics Instability

Summary: positioning a patient in prone position under anaesthesia significantly alters cardiovascular physiology. cervical myelopathy patients are known to have autonomic dysfunction. such patients when positioned in prone position under anaesthesia carry a higher risk of developing hemodynamic changes and this can compromise spinal cord perfusion. this prospective observational study was conducted on 30 patients with cervical myelopathy who underwent surgery in prone position at nimhans, bangalore hospital. the non invasive cardiac output monitor (nicom, cheetah medicals) was used to record various hemodynamic parameters. the hemodynamic parameters were recorded at baseline, post induction, post intubation, prior to prone position, post prone position, and every five minutes thereafter upto 20mins. the hemodynamic parameters that were recorded using the nicom monitor: * hr - heart rate (beats /min) * nibp - non invasive blood pressure (mmhg) * map - mean arterial pressure(mmhg) * co - cardiac output (l/min) * ci - cardiac index (l/min/m2) * sv - stroke volume (ml/beat) * svv -stroke volume variability (%) * tpr - total peripheral resistance (dynes. sec/cm5)


Eligibility criteria:
inclusion criteria: cervical myelopathy patients undergoing surgery in prone position with: * asa class i , ii and iii * age between 18 to 65 years * nurick's grade 2 or more exclusion criteria: * atlanto occipital dislocation and cervicomedullary junction pathology * tumour pathology * diabetic patients * patients positioned prone in the awake state (without induction of anaesthesia)

Keywords: prone positioning non-invasive cardiac output monitoring
contrast nephropathy and nitrates

Conditions: Contrast Induced Nephropathy

Summary: contrast-induced nephropathy (cin) is a complication of percutaneous coronary angiography that occurs in about 10 to 20% of patients exposed to contrast media. iodinated contrast is used during coronary angiography to see the coronary arteries. it has been shown that exposure to this agent may cause kidney injury. cin usually goes away on its own but in some high risk patients it progresses into renal failure. this research study offers a new possible option to prevent cin. we propose that if intravenous nitroglycerin is given before the procedure it may lower the chances of developing contrast-induced nephropathy.

the contrast nephropathy and nitrates trial (conan) is a single center, randomized, 1 x 1 factorial clinical trial designed to test the effects of intravenous nitroglycerin infusion in renal function given prior to pci. specific aims for this trial include: * to determine whether the intravenous nitrates have any effect on the glomerular filtration rate (gfr) after the exposure to contrast media. * to determine if intravenous nitroglycerin will decrease the incidence of contrast induced nephropathy. 400 patients with a mehran score of \> 6 and a pre-procedural creatinine measurement will be enrolled. following baseline assessments, patients will be randomly assigned to receive intravenous infusion nitroglycerine plus intravenous normal saline or normal saline only. subjects will participate in this study from the time they sign consent (prior to angiographic procedure), until 48-72 hours post procedure.

Eligibility criteria:
inclusion criteria: 1. patient must be scheduled for percutaneous coronary angiography. 2. patients must have a mehran score more or equal to 6 before the procedure. 3. patients must have baseline creatinine and hemoblogin drawn before the procedure. 4. signed informed consent. exclusion criteria: 1. patients on renal replacement therapy before randomization, will be excluded. 2. being exposed to any types of nitrates 48 hours prior to randomization, 3. history of allergic reaction to any of the components of intravenous nitroglycerin. 4. exposure to contrast media 4 days prior randomization. 5. planned revascularization in the next 24 to 48 hours of the first pci procedure. 6. the patient is hypotensive (\<90/60mmhg) at the time of randomization.
yoomi: effect of gamified physical therapy exercise software on inpatient mobility

Conditions: Weakness, Muscle; Delirium in Old Age; Muscle Atrophy or Weakness; Muscle Loss; Hospital Acquired Condition; Physical Disability; Physical Inactivity

Summary: patients admitted to the hospital often develop functional impairments due to being in bed most of the day. each day of bedrest leads to significant muscle loss. as a result, many patients become dependent on others or require rehabilitation at a facility to improve mobility and function prior to returning home. staff in the hospital is limited and often unable to mobilize patients every day while hospitalized. the investigators are testing a new experimental gamified physical therapy exercise software to see if it can be a fun, enjoyable way to help mobilize patients without the assistance of staff. the primary aim of this pilot/proof of concept study is to determine whether gamified physical therapy software can help inpatients exercise within the safety of their own beds and preserve pre-hospitalization function.


Eligibility criteria:
inclusion criteria: * \>= 65 years of age * english-fluency in reading and speaking * capacity to consent * enrolled in help program * attending physician confirms there are no medical contraindications to in-bed exercises exclusion criteria: * unstable psychiatric illness * unstable/critically ill patients requiring icu-level of care * surgical tube present (e.g. jp drains) * surgery during the hospitalization * bed rest activity order

Keywords: artificial intelligence (ai) physical therapy hospitalization related muscle atrophy hospitalization associated decline inpatient rehabilitation ai driven physical therapy
pulmonary function test study - automated interpretation

Conditions: Respiratory Disease

Summary: a multicentric study to explore variability when clinicians are intrepreting lung function tests. comparison with results of in-house built software for automatic interpretation.

this is a multi-center non-interventional retrospective study that will use data obtained from clinical routine. in the hospital, subjects with or without respiratory complaints undergo subset of (or complete) pulmonary function tests if clinically indicated. results of these tests, expressed as numerical values are send to the clinical workstation (kws) for immediate clinical use. these results are subsequently being interpreted by a clinician. a random sample of 50 lung function printouts of subjects followed at the leuven pulmonary service with a final diagnosis of a respiratory disease have been randomised. these anonymized printouts will be given to different pulmonologists for examination in 18 different centers and compared with the interpretation of in-house developed software.

Eligibility criteria:
inclusion criteria: 1. age more than 18 years 2. completed one or more pulmonary function tests exclusion criteria: 1. younger than 18 2. lung transplantation, lung cancer.
exodx prostate evaluation in prior negative prostate biopsy setting

Conditions: Prostate Cancer

Summary: the study is designed to confirm the performance of the exodx prostate test in prior negative biopsy patients now presenting for a repeat prostate biopsy. note: exodx prostate test results are collected for correlation to biopsy results and are not disclosed to the physician or study subject.

primary endpoint: evaluate the correlation of the exodx prostate test results with the outcome of prostate biopsies in a prior negative repeat biopsy patient cohort. secondary endpoints (exploratory): 1. evaluate the clinical performance of the exodx prostate test at the cut-point of 15.6 defined for the initial biopsy patient cohort. 2. associate exodx prostate test results with other ancillary studies including the use of radiographic imaging (e.g. multiparametric mri). 3. evaluate the correlation of exodx prostate as a function of risk. it is known that a higher exodx prostate score correlates to a higher risk of finding prostate cancer, including hgpc, upon biopsy. 4. evaluate exodx prostate with and without inclusion of standard of care parameters such as psa, ethnicity, dre, age and family history.

Eligibility criteria:
inclusion criteria: * 50+ years of age * clinical suspicion for prostate cancer * elevated prostate-specific antigen between 2.0-10 ng/ ml * at least one (1) prior negative prostate biopsy exclusion criteria: * use of medications or hormones that are known to affect serum psa levels within 3-6 months of study enrollment including 5-alpha-reductase inhibitors used in the treatment of an enlarged prostate gland (benign prostatic hyperplasia). drugs in this class are finasteride (proscar, propecia) and dutasteride (avodart). * clinical symptoms of urinary tract infection (including prostatitis) at the time of enrollment. * history of prostate cancer. * history of invasive treatments for benign prostatic hypertrophy (bph) or lower urinary track symptoms within 6 months of study enrollment. * no known hepatitis status (all types) and/or hiv documented in patient's medical record. * patients with history of concurrent renal/bladder tumors.

Keywords: exosome exodx prostate
computed tomography perfusion (ctp) to predict response to recanalization in ischemic stroke project (crisp)

Conditions: Stroke

Summary: the overall goal of the ctp to predict response to recanalization in ischemic stroke project (crisp) is to develop a practical tool to identify acute stroke patients who are likely to benefit from endovascular therapy. the project has two main parts. during the first part, the investigators propose to develop a fully automated system (rapid) for processing of ct perfusion (ctp) images that will generate brain maps of the ischemic core and penumbra. there will be no patient enrollment in part one of this project. during the second part, the investigators aim to demonstrate that physicians in the emergency setting, with the aid of a fully automated ctp analysis program (rapid), can accurately predict response to recanalization in stroke patients undergoing revascularization. to achieve this aim the investigators will conduct a prospective cohort study of 240 consecutive stroke patients who will undergo a ctp scan prior to endovascular therapy. the study will be conducted at four sites (stanford university, st luke's hospital, university of pittsburgh medical center, and emory university/grady hospital). patients will have an early follow-up mri scan within 12+/-6 hours to assess reperfusion and a late follow-up mri scan at day 5 to determine the final infarct.


Eligibility criteria:
inclusion criteria: 1. be 18 or older; 2. have a clinical diagnosis of ischemic stroke and a score of 5 or more points on the nihsss; 3. be scheduled to undergo intraarterial (ia) therapy for acute hemispheric stroke (either as primary therapy or as adjuvant therapy following intravenous tpa treatment); 4. be scheduled to have a standard ct including perfusion imaging and ct angiography of the circle of willis (cta) prior to ia therapy; 5. begin intra-arterial thrombectomy within 90 minutes of completion of the ct scan and within 18 hours of symptom onset. (start of ia therapy is defined as the time of insertion of the femoral artery sheath; time of brain scan is defined as the time that the scan is completed); and 6. have provided informed consent. exclusion criteria: 1. have any pre-existing illness resulting in a modified rankin scale score of 3 or higher prior to the qualifying stroke; 2. are pregnant.
virtual training role-plays to improve patient suicide outcomes in primary care settings

Conditions: Suicidal Ideation

Summary: simmersion, in collaboration with the institute for family health (ifh) and the educational development center (edc) propose to develop a web-based training product, suicide prevention role-plays for interactive training (spirit), a series of 4 modules to train providers to more effectively manage patients who screen positive for risk of suicide in this phase i/phase ii fast-track application. if funded, the team will develop the risk assessment module in phase i and utilize a within group pre-post design to evaluate its feasibility. twenty practicing clinicians will be recruited to utilize the module and complete a pre-post knowledge test. in phase ii, the team will develop safety planning, access to lethal means, and willingness to accept a referral modules. the efficacy of the product to positively influence patient outcomes will be tested with a historically controlled trial (hct) enlisting 65 practicing clinicians across five ifh sites. all providers will be trained and patient outcomes will be tracked for 6 months post training. this data set will be compared to 6 months of historical data for the same provider group. primary outcomes of this study will measure the participants' ability in obtain improved patient outcomes related to: 1) rate of same-day c-ssrs screening; 2) rate of suicide being added to the problem list; 3) rate of same-day safety planning; 4) rate of same day c-ssrs lifeline/recent completion; 5) rate of same-day risk assessment; 6) rate of acceptance and attendance to within-institute referrals for post intervention patients who are offered the referral at the first visit; 7) and lower rates of documented suicide attempts. ultimately, the development and successful testing of this product would provide the us health care system a novel technology to scale up a clinician's confidence and skill to better manage patients who identify as at-risk for suicide. additionally, if effective, this product will have a direct impact on patient outcomes, a vital component to any training product that attempts to train health care professionals. the utility and scalability of the proposed product will move health care systems toward the goal of zero deaths from suicide consistent with the zero suicide approach.


Eligibility criteria:
inclusion criteria: (1) hold an active license issued by the state of new york for their profession and be in good standing; (2) actively see patients at an ifh site; and (3) have completed ifh's mandated suicide prevention training. exclusion criteria: (1) have not completed their ifh suicide prevention training as outlined in the ifh's suicide prevention training policy; or (2) have uncorrected vision or hearing problems that prevent the person from using the software. specific to phase ii an additional criteria is (3)participated in the phase 1 feasibility testing.

Keywords: safety planning access to lethal means zero suicide
human papilloma viruses (hpv) vaccine adherence community clinic study

Conditions: Patient Compliance

Summary: there has been very limited research that has looked at electronic reminders (text messages) and its effectiveness in adherence to vaccination among low-income minority populations. results have shown that text messages, among low-income parents and adolescents who were identified as having a cellphone, is an effective strategy to increase the likelihood of adolescent vaccination adherence. hard copy and electronic messaging reminders have also been proven to be effective when coupled with other prevention strategies for immunizations for influenza and pneumococcal pneumonia and screening for colon, breast, and cervical cancer in adults. additionally, merck and co. recommend electronic reminders in their patient compliance program as a key strategy for adherence. to our knowledge, this community-based pilot intervention study will be the first to assess electronic reminders and hpv vaccine initiation and adherence among rural uninsured and medicaid populations. the investigators hypothesize that adolescent whose parents who receive the intervention will be more likely to initiate hpv vaccination and be compliant at 3 months and at 7 months as compared to the control group.


Eligibility criteria:
inclusion criteria: * parent/caretaker has medicaid or is uninsured * parent/caretaker has a child between 11- 18 y/o * parent/caretaker should be able to read english or spanish * parent/caretaker should have a phone and/or email address to provide for the study exclusion criteria: * parents who have children younger than 11 or older than 18 years of age * parents who are not currently uninsured or enrolled in medicaid/medicare. * parent/caretaker's child who received the 1st dose of hpv vaccine before enrolling in study

Keywords: hpv vaccine adherence electronic reminders
evaluation of visual acuity in myopic cataract patients using trifocal intraocular lens

Conditions: Cataract; Myopia; Intraocular Lens

Summary: the panoptix trifocal iol is a new trifocal intraocular lens which is proved to provide good range of vision for distance, intermediate and near and good visual quality in cataract patients with normal axial length. but whether it can get the same visual quality in myopia is still unknown

there are a few publications of multi-focal iols on chinese patients with high myopia. from published papers, it is known that performance of multifocal iols is satisfied in myopic patients. however there is no publication to investigate panoptix in moderate and high myopic patients. so it is imperative to demonstrate good performance of panoptix in those special patients. the purpose of this study is to assess visual performance and patient satisfaction after the implantation of panoptix in myopic patients.

Eligibility criteria:
inclusion criteria: 1. axial myopic patients（refractive condition match the axial length after eliminate the nuclear cataract induced myopia factor） 2. corneal astigmatism \<1.0d (iol-master 500/700, carl zeiss meditec, jena, germany); 3. eyes with pupil diameter\>2.5 mm (photopic) and\<6 mm (mesopic) (pentacam hr, oculus optikgerate gmbh); 4. eyes with angle kappa\<0.50 mm (pentacam hr); 5. eyes with corneal spherical aberration\<0.50 (pentacam hr) exclusion criteria: 1. irregular corneal astigmatism 2. any retinal disease, macular disease(including myopic md and retinal diseases) could affect va, glaucoma and other severe intraocular diseases 3. moderate-severe dry eye 4. amblyopia（bcdva\<0.7 before cataract appears） 5. patients having difficulties with examinations or 3 months' follow-up.

Keywords: myopia visual acuity monocular defocus curve binocular contrast sensitivity