Kornimate/medical-research-clean huggingface dataset:
acupuncture treatment for vertebral compression fracture

Conditions: Spinal Fracture; Compression Fracture; Fractures, Bone

Summary: patients with vertebral compression fractures (vcf) may experience pain, limitation of daily activities, and various complications (e.g., insomnia, constipation, urinary infection, depression, diminished quality of life). objective: this study aims to evaluate the effectiveness, safety and feasibility of acupuncture treatments to achieve pain relief and functional recovery in patients with vcf.

patients who have subacute or chronic vertebral compression fracture in one or more thoracic/lumbar vertebral body are eligible. patients who have willingness to participate and provide written informed consents will be treated to the pusan national university korean medicine hospital with once to three times per weak for six weeks approximately. (total 12-18 sessions)

Eligibility criteria:
inclusion criteria: * is at least 19 years of age * radiographic confirmation of one more subacute or chronic stable vertebral compression fractures (x-ray, computerized tomography, or magnetic resonance imaging) * patient-reported pain intensity equal or greater than 4 points on 0 to 10 vas scale at baseline * willingness to participate in the study and provide written informed consent * is able to give written consent independently or with a supporter's help exclusion criteria: * pathological fracture (malignancy, myeloma, metabolic disease, etc.) * spine malformation * pregnancy, infection, impaired cognitive function * hypersensitive reaction to acupuncture treatment * need for surgical treatment 1. neurologic deficit: spinal cord injury, cauda equina syndrome 2. unstable fracture: three-column collapse, burst fracture, posterior ligament rupture, distraction fracture 3. scoliotic angle ≥ 12°

Keywords: integrative treatments korean traditional medicine
the effect of listening to the holy quran on vital signs in coma patients

Conditions: Sequelae of; Complications Surgical and Medical Care

Summary: the aim of this study is to examine the effect of the holy quran listened to to coma patients on their vital signs. does listening to the holy quran have a positive effect on the life values of coma patients?

this study aims to examine the effect of listening to the holy quran on vital signs (fever, pulse, respiration, systolic-diastolic blood pressure, saturation) in surgical intensive care unit patients. the unique value of this study, unlike other studies, is to examine the positive changes in patients' vital signs by listening to the holy quran (surah rahman) instead of classical music.

Eligibility criteria:
inclusion criteria: * being over 18 years of age * being a surgical intensive care patient * having a glasgow coma score of 8 points or less exclusion criteria: * the patient must be under 18 years of age * have a glaskow coma score above 8 points * be out of coma during the time the research continues
mommy-baby treatment for perinatal depression

Conditions: Depressive Disorder, Major; Postpartum Depression

Summary: perinatal depression is a major public health problem, affecting 15% of women during pregnancy through the postpartum period, with adverse consequences for the mother, the fetus, the infant, and the family. despite increasing evidence of the importance of this critical risk interval, little research has investigated the effects of depression treatment during pregnancy on infant outcomes. the purpose of this study is to test the feasibility, acceptability, and effectiveness of a new intervention, interpersonal psychotherapy for the mother-infant dyad (ipt-dyad). this intervention begins during pregnancy and continues with the mother and infant until one year postpartum. the investigators hypothesize that ipt-dyad will be better than treatment as usual in reducing depressive symptoms, improving psychosocial functioning,increasing parenting self-efficacy, improving infant emotional development, and enhancing mother-infant relationship quality.


Eligibility criteria:
inclusion criteria: * pregnant women * 18 years and older * between 12 and 30 weeks gestation * score greater than or equal to 13 on edinburgh depression scale * structured clinical interview (scid-iv) diagnosis of major depressive disorder, dysthymia, or depressive disorder, not otherwise specified * english speaking exclusion criteria: * substance abuse or dependence in past 3 months * active suicidal or homicidal ideation * bipolar disorder, psychotic disorder * unstable medical condition or other medical/obstetrical complication * evidence of severe intimate partner violence * ongoing psychosocial or pharmacotherapy for depression

Keywords: depression pregnancy postpartum psychotherapy
preoperative steroid in abdominal wall reconstruction: a double-blinded randomized clinical trial

Conditions: Hernia, Ventral

Summary: patients who undergo abdominal wall reconstruction for giant ventral hernia repair will be randomized to either methylprednisolone or saline preoperatively, to examine the effects of methylprednisolone on postoperative pain, nausea and recovery after giant ventral hernia repair.

preoperative high-dose glucocorticoid has been shown to attenuate the postoperative inflammatory response leading to decreased morbidity and length of stay (los) after colorectal and aortic surgery, as well as decreased pain and subjective recovery after orthopedic surgery. methylprednisolone (mp, "solu-medrol") is one such glucocorticoid, which has been shown to be safe for usage in surgery. giant ventral hernia repair is associated with a high risk of postoperative morbidity and prolonged los compared with other hernia repair procedures requiring laparotomy. further, the total costs of these procedures remain high. systemic administration of high-dose preoperative mp in ventral hernia repair has only been described anecdotally in the literature, and never with the aim to improve the treatment of this patient group specifically. it is however unknown to what extent benefits weigh out downsides from usage of high-dose mp in giant ventral hernia repair, patients often at increased risk of postoperative wound infection. on this background we hypothesize that a preoperative high-dose mp results in improved recovery after giant ventral hernia repair compared with placebo.

Eligibility criteria:
inclusion criteria: * ventral incisional hernia with horizontal fascial defect \> 10 cm described at either computed tomography scan or clinical assessment * planned elective open hernia repair * ability to speak and understand danish * ability to give written and oral informed consent exclusion criteria: * daily use of systemic glucocorticoid * new york heart association class 3-4 heart disease * chronic renal failure (egfr \< 60 ml/min per 1.73 m2) * insulin-dependent diabetes * excessive abuse of alcohol * known allergy to methylprednisolone or any substance in study medicine * planned pregnancy within three months postoperatively * pregnancy, evaluated by pregnancy test preoperatively * breastfeeding * actively treated ulcer disease up to one month preoperatively

Keywords: ventral hernia abdominal wall reconstruction enhanced recovery after surgery steroid
investigation of the effects of robot assisted gait training with virtual reality on cognitive functions in stroke patients

Conditions: Exoskeleton Device; Locomotion; Stroke

Summary: it was planned to examine the effects of robot-assisted walking training supported by virtual reality on cognitive functions, quality of life and activities of daily living in individuals with subacute stroke. in this context, only conventional physiotherapy was applied to one group, while the other group was given exercises with lokomat in addition to conventional physiotherapy.

according to the definition of the world health organization, stroke is a clinical syndrome characterized by the rapid establishment of signs and symptoms of focal loss of cerebral function for no apparent reason other than vascular causes. symptoms last longer than twenty-four hours or may result in death. stroke is the second leading cause of death in the world and the first cause of disability and loss of work force. many stroke survivors are dependent on someone else for some part of their daily lives, have limitations in their daily and social activities, and have significantly lost their quality of life. cognitive disorders after stroke are manifested by difficulties in information processing due to brain damage. the most common cognitive effects in stroke; attention, memory, orientation, executive dysfunction and aphasia. for cognitive rehabilitation it is known that lokomat combined virtual reality applications is more effective than lokomat exercises without virtual reality in individuals with chronic stroke. our research aims to contribute to the literature by revealing the cognitive functions, adl and quality of life of locomotive exercises together with virtual reality in individuals with subacute stroke. our research will be carried out in the robotic rehabilitation laboratory of physical therapy and rehabilitation hospital in ankara city hospital. the population of the study is the stroke clinics of the same hospital. individuals with subacute stroke who volunteered to participate in the study will be included in the study. all patients will receive conventional physiotherapy five days a week for six weeks, and the study group will receive with lokomat three times a week in addition to conventional physiotherapy. the patients will be evaluated by a therapist other than the practitioner before and after the treatment in two groups, one of which is the study group and the other is the control group.

Eligibility criteria:
inclusion criteria: * first stroke * subacut stroke (from 21 days to 180 days) * can do lokomat exercises exclusion criteria: * incompatibility to lokomat (femur lenght problems, severe cognitive impairment, excess weight etc.)

Keywords: lokomat augmented performance feedback
preoperative nutritional intervention and outcomes of children submitted to heart surgery for congenital heart diseases

Conditions: Congenital Heart Disease; Malnutrition

Summary: the hypothesis of this study is a nutrition preoperatively in infants and children undergoing elective cardiac surgery with cardiopulmonary bypass leads to improvement in nutritional status, intervention, and that this results in good postoperative results.

if this hypothesis is confirmed, there will be subsidies for systematic implementation of nutritional interventions in patients seen in service.

Eligibility criteria:
inclusion criteria: * patient with congenital heart disease requiring elective surgical correction; * age\> 30 days and ≤ 5 years, with the aim of excluding the neonatal period, which are operated children with complex heart defects, and older children, where the time living with the disease damages the myocardium and the pulmonary circulation, leaving only children with fewer serious and, in general, are less subjected to complex surgery diseases. exclusion criteria: * chronic gastrointestinal diseases (defects, malabsorption, celiac disease, inflammatory bowel disease, diabetes mellitus); * patients with other organic defects that may compromise the growth and / or nutritional status; * patients undergoing emergency surgery; * request of parents or guardians at any time; * patients receiving exclusive breastfeeding; * died during the study period; * patients using cardiac pacemaker or other electrical or electronic device that interferes with the reading of the electrical bioimpedance.

Keywords: children congenital heart disease nutritional status bioelectrical impedance
a study of capecitabine (xeloda) in participants with locally advanced or metastatic pancreatic cancer

Conditions: Pancreatic Cancer

Summary: this study will evaluate the efficacy and safety of oral capecitabine plus intravenous (iv) gemcitabine in participants with locally advanced or metastatic pancreatic cancer. the anticipated time on study treatment is 3 to 12 months, and the target sample size is 56 individuals.


Eligibility criteria:
inclusion criteria: * adult participants 18 to 75 years of age * locally advanced or metastatic pancreatic cancer exclusion criteria: - prior chemotherapy for pancreatic cancer
an open label extension (ole) study to evaluate long-term safety and tolerability of pelacarsen (tqj230)

Conditions: Hyperlipoproteinemia (a)

Summary: this non-randomized, open-label extension study will provide post-trial access to pelacarsen (tqj230) to participants in germany with hyperlipoproteinemia(a) and established cardiovascular disease who have successfully completed the double-blind parent study (ctqj230a12302).

this study will allow to evaluate a long-term safety and tolerability of pelacarsen (tqj230) 80 mg qm in patients. all consenting participants from the parent study who meet the eligibility criteria will be participating in this open label extension study. the maximum duration of this study is approximately 5 years.

Eligibility criteria:
inclusion criteria: * signed informed consent * participant has successfully completed the parent study and is considered safe to participate by investigator's clinical judgement. exclusion criteria: * any medical condition(s) that may put the participant at risk in the investigator's opinion * pregnant or nursing (lactating) women * women of child-bearing potential, unless they are using effective methods of contraception during dosing and for 16 weeks (= 5 times the terminal half-life) after stopping of study medication

Keywords: lipoprotein(a) cardiovascular disease apheresis post trial access pelacarsen (tqj230)
a safety, tolerability, and efficacy study of ibi314 in patients with mild to moderate covid-19

Conditions: COVID-19

Summary: this is a phase 1/2 study evaluating the safety, tolerability and efficacy of ibi314.

phase 1 is a randomized, double-blind, placebo-controlled, single ascending dose study in up to 24 health volunteers. this phase of the study is designed to assess the safety, tolerability and pk of ibi314 administered as a single iv infusion. phase 2 is a randomized, double-blind, placebo-controlled expansion study in approximately 198 mild to moderate adult patients with covid-19. this phase of the study is designed to assess the efficacy, safety, pk and pd of ibi314.

Eligibility criteria:
main inclusion criteria: first onset of covid-19 symptoms \<7 days at randomization, symptoms such as fever and/or chills, fatigue, muscle or body aches, headache, new loss of taste or smell, sore throat, congestion or runny nose, nausea or vomiting, and diarrhea. have a positive sars-cov-2 reverse transcription-polymerase chain reaction (rt-pcr) test using an appropriate sample such as nasopharyngeal (np), nasal, oropharyngeal, or saliva within 72 hours prior to randomization. a historical record of a positive result from a test conducted ≤72 hours prior to randomization is acceptable. male or female patients ≥18 years of age at the time of signing informed consent. agree to use an adequate method of contraception throughout the study period and for 6 months after the dose of study drug is administered. women of childbearing potential (wocbp) must have a negative urinary pregnancy test at screening. main exclusion criteria: have oxygen saturation (spo2) ≤93 % on room air at sea level or a ratio of arterial oxygen partial pressure (pao2 in millimeters of mercury) to fractional inspired oxygen (fio2) \<300, respiratory rate ≥30 per minute, heart rate ≥125 per minute. have evidence of multi-organ dysfunction/failure. systolic blood pressure \<90 mmhg, diastolic blood pressure \<60 mmhg, or requiring vasopressors. require or anticipated impending need for endotracheal intubation, mechanical ventilation, oxygen delivered by high-flow nasal cannula noninvasive positive pressure ventilation, extracorporeal membrane oxygenation (ecmo).
the optical coherence tomography in age-related macular degeneration study: the oct in amd study

Conditions: Macular Degeneration

Summary: the optical coherence tomography (oct) is a non-contact, non invasive method to examine the retina by providing cross-sectional scans through the retina. measurements of the retinal thickness based on automatically set border lines created by threshold algorithm provide information concerning the amount of intraretinal fluid and activity of the lesion. in this study the reproducibility of retinal thickness measurements in patients suffering from age-related macular degeneration performed by two independent examiners of two examinations of the same day but performed in a time interval of at least two hours should be evaluated. using the macular thickness program of stratus oct, 6 radial lines through the center of the foveal avascular zone are performed, differences between the first and second measurement will be investigated by a 95% confidence interval, a bland-altman plot (with corresponding regression analysis) and a random effect model with time, examiner and diagnosis as fixed factors. although threshold algorithm failures and fixation problems are common in age-related macular degeneration evidence of reproducibility and repeatability of maximum retinal thickness is expected.


Eligibility criteria:
inclusion criteria: * age over 50 years * age related macular degeneration exclusion criteria: * macular pathologies other than age related macular degeneration (diabetic maculopathy, macular pucker, macular hole, * visualization of the macula not possible (dens cataract, vitreous haemorrhage) * not consented patients

Keywords: age-related macular degeneration optical coherence tomography retinal thickness exudative age-related macular degeneration
measuring the impact of real time fmri neurofeedback in borderline personality disorder

Conditions: Borderline Personality Disorder

Summary: this study will test the impacts of real time fmri neurofeedback in patients with borderline personality disorder. this is a pilot study in a small number of people enrolled in clinical programs at yale new haven hospital.


Eligibility criteria:
inclusion criteria: 1. enrolled in ynhh dbt-iop 2. must meet specific clinical criteria 3. inclusion in experimental group requires participants meet standard safety and quality control requirements for mr scanning 4. for female participants, not pregnant and willing to use a reliable method of contraception during the study exclusion criteria: 1. iq\<70 2. vision problem not able to be corrected to normal range 3. medication changes w/in one month 4. lifetime hx of schizophrenia, schizoaffective d/o, bipolar i disorder. 5. illicit substance use within 7 days of mri scans 6. taking scheduled opiates 7. taking scheduled benzodiazepines 8. taking scheduled anti-histamines 9. history of seizures 10. significant current or past neurologic illness 11. bmi \< 16.5
the effect of breast cancer and breast self-examination

Conditions: Breast Carcinoma

Summary: background: somali women face extremely high mortality and incidence rates for breast cancer (bc). one of the suggested techniques for screening for breast cancer early detection is breast self-examination, or bse. studies have revealed that somalian women, however, lack sufficient understanding and practice about bc and bse. in this study, female students at a university in mogadishu, somalia, had their knowledge, attitudes, health beliefs, and bse practices evaluated with reference to the effects of health belief model-based health education addressing bc and bse. methods: it was conducted as a randomized controlled study on 86 female university students in mogadishu, somalia, between september 2021 and june 2022. randomization was used to assign participants to the intervention group (n = 43) and control group (n = 43). data were gathered using two instruments: a self-administered questionnaire was the first tool used to gather information on individuals\&#39; sociodemographic and level of awareness about bc and bse. the health belief model scale is the second instrument. a validated checklist and a modified structured questionnaire were used to gather data. subsequently, the students in the experimental group took part in the three 90-minute training sessions that made up the program. the control group did not receive any intervention. three months later, further student data were gathered. data analysis was performed using ibm-spss software version 20, descriptive and inferential statistical tests (t-test, chi-square, repeated measures).


Eligibility criteria:
inclusion criteria: * turkish and somali instructors work together at the faculty and students are given education in turkish. if students are successful in one year of turkish preparation, they can then continue to the department of their choice. the population of the research consisted of 500 female students over the age of 18 studying at the recep tayyip erdoğan faculty of health sciences in mogadishu, somalia. exclusion criteria: -

Keywords: awareness belief breast cancer breast self-examination health education students somalia
linkage and retention: a randomized trial to optimize hiv/tb care in south africa

Conditions: HIV

Summary: the purpose of this study is to test the effects of a health system navigator intervention on rates of linkage to human immunodeficiency virus (hiv) and tuberculosis (tb) care among newly diagnosed hiv-infected outpatients in durban, south africa. subjects will be approached in the outpatient department and enrolled prior to an hiv test. subjects will then be randomized to the navigator arm or the standard of care arm. subjects in the navigator arm will receive scheduled phone and short message service (sms) contacts throughout the follow-up period to help guide them through the hiv and tb care pathways. the navigator will provide personalized support to help subjects overcome barriers they may face along the way.

this project is a randomized controlled trial of an intervention to improve linkage to hiv and tb care for south africans undergoing hiv testing. subjects undergoing hiv testing will be enrolled at three sites in the greater durban area. these sites comprise two hospital-affiliated outpatient departments and primary health clinics served by a mobile health van. routine tb screening, regardless of signs or symptoms, will be offered to all hiv-infected participants. hiv-infected participants will be randomized to determine whether they will be assigned to a health system navigator or will receive the current standard of care in durban. block randomization will be stratified by site and gender, with blocks of varying length. the health system navigator will help patients identify barriers to entering care and devise solutions, optimize use of available resources, and serve as a trusted social supporter who is knowledgeable about the health care system but remains outside of it. the health system navigator will help subjects engage the hiv and tb care system through face-to-face contact, telephone conversations, and short messaging service sms text reminders which are free for patients to receive. these phone contacts and sms will follow a standardized protocol. we will evaluate the efficacy of the intervention, as measured by increased rates of antiretroviral therapy (art) initiation and, for those with tb co-infection, tb treatment completion. we will also evaluate the cost and cost-effectiveness of this intervention.

Eligibility criteria:
inclusion criteria: * english or zulu speaking * presenting for outpatient care * voluntarily undergoing an hiv test * able to give informed consent * report no prior hiv test * willing to share hiv and tb test results with research staff exclusion criteria: * pregnant * lying in a stretcher * not oriented to person, place and time