Kornimate/medical-research-clean huggingface dataset:
b-left hf: biventricular versus left univentricular pacing with implantable cardiac defibrillator (icd) back-up in heart failure patients

Conditions: Heart Failure; Ventricular Dysfunction; Heart Diseases

Summary: the purpose of this study is to demonstrate that biventricular pacing (biv) and left univentricular (left ventricular \[lv\] only) pacing are safe and effective for cardiac resynchronization therapy in heart failure patients implanted with a cardiac resynchronization therapy defibrillator (crt-d) device. the hypothesis to be tested by this clinical investigation is that patients indicated for an icd with cardiac resynchronization therapy respond as well to lv only pacing as to biv pacing.


Eligibility criteria:
inclusion criteria: * have an approved indication for implantation of an icd for treatment of a life-threatening ventricular tachyarrhythmia(s) * have advanced heart failure with a new york heart association (nyha) classification of iii or iv, despite receiving a minimum of 30 days of stable optimal pharmacological therapy * have a ventricular conduction delay manifested as a qrs width \>= 130 ms * have a left ventricular end diastolic diameter (lvedd) \>= 55 mm * have a left ventricular ejection fraction (lvef) \<= 35% exclusion criteria: * have a crt device already implanted * have a standard indication for bradycardia pacing * have a history of chronic atrial fibrillation \[af\] (continuous af lasting \> 1 month) within 1 year prior to enrollment or have undergone cardioversion for af in the past month) * have the ability to walk \> 450 meters during the 6-minute walk test * have uncorrected primary valvular disease * have had a recent myocardial infarction, unstable angina or cardiac revascularization (percutaneous transluminal coronary angioplasty \[ptca\] or coronary artery bypass graft \[cabg\]) within 1 month of enrollment * have had cerebrovascular accident (cva) or transient ischemic attack (tia) within 3 months of enrollment * have a life expectancy of less than one year * are unable to comply with the follow-up schedule and tests * are minors (age below 18 years) * are pregnant or are planning for pregnancy in the next 6 months

Keywords: ventricular dyssynchrony
dose tapering study of adalimumab in psoriasis

Conditions: Psoriasis Vulgaris

Summary: the optimal therapeutic serum trough level (ctrough) of adalimumab was defined between 3,5 and 7,0 µg/ml in patients with plaque type psoriasis. an adalimumab ctrough above this therapeutic range did not add clinical response. based on this therapeutic window, the introduction of dose adjustments based on ctroughs (therapeutic drug monitoring) will be further validated in a prospective randomized-controlled trial. here, we aim to determine whether, in patients with a good clinical response and supratherapeutic adalimumab ctroughs, dose reduction is able to maintain favorable clinical outcome.

patients will be included after signing informed consent and randomized in either a standard dose arm or a concentration based arm based on prior ctrough measurements. in the concentration based arm, dosing frequency will be lowered to once every 3 weeks. if patients still have supratherapeutic ctroughs of adalimumab, these patients will continue adalimumab self-administration every 4 weeks. in the standard based arm, patients will continue on standard dosing schedule. during each study visit blood will be taken in order to quantify ctroughs. in addition, psoriasis area and severity index (pasi) and investigator's global assessment (iga) score will be evaluated by a physician. patients complete the dermatology life quality index (dlqi) and european quality of life eq-5d instrument at each visit. in addition, in a subset of patients in each treatment arm, additional sampling will be collected by dried blood spot sampling in order to build a pk(pd) model for adalimumab.

Eligibility criteria:
inclusion criteria: 1. participants must have a clinical or histological diagnosis of chronic plaque-type psoriasis for at least 6 months prior to inclusion 2. participants must have a stable disease during maintenance on adalimumab (absolute pasi \< 3) 3. participants are not allowed to use topical steroids from 7 days before randomization until the end of the study (week 48). 4. participants must sign an icf indicating that he or she understands the purpose of, and procedures required for, the study and is willing to participate in the study exclusion criteria: 1. participants who have currently a predominant nonplaque form of psoriasis 2. participants who are pregnant, nursing or planning a pregnancy while enrolled in the study or within 12 weeks after receiving the last administration of study intervention 3. participants who are unable or unwilling to undergo multiple venapunctures 4. participants who are treated according to a different dosing schedule than standard dosing of adalimumab (regular dose regimen every 2 weeks; 40 mg)

Keywords: therapeutic drug monitoring psoriasis adalimumab
comparison of the hemodynamic effect of three positions during induction of anesthesia

Conditions: Post-induction Hypotension

Summary: the most common methods for prevention of post-induction hypotension are preoperative fluid loading and vasopressors. leg elevation induces an intrinsic transfusion of 150 ml blood from the lower limbs to the central fluid compartment. leg elevation was previously reported by our group to decrease the incidence of maternal hypotension after spinal anesthesia for caesarean delivery. passive leg raising was also reported to provide a stable hemodynamic profile during induction of anesthesia for cardiac surgery. head-down position was previously reported as a useful measure for management of hypovolemia in various patient groups. no studies to the best of our knowledge had evaluated the compare both positions (leg elevation position and head-down position) during induction of anesthesia in non-cardiac surgery

upon arrival to the operating room, routine monitors (ecg, pulse oximetry, and non-invasive blood pressure monitor) will be applied; intravenous line will be secured, and routine pre-medications (ranitidine 50 mg and midazolam 3-5 mg) will be administrated. before induction of anesthesia, patients will be randomly allocated into:supine group, head-down group or leg elevation group baseline mean arterial blood pressure will be obtained as average of 3 reading before induction of anesthesia at supine position. induction of anesthesia will be achieved using fentanyl (2 mcg/kg), propofol (2 mg/kg), and atracurium (0.5 mg/kg). endotracheal tube will be inserted after 3 minutes of mask ventilation. anesthesia will be maintained by isoflurane (1-1.5%) and atracurium 10 mg increments every 20 minutes. ringer lactate solution will be infused at a rate of 2 ml/kg/hour. any episode of hypotension (defined as mean arterial pressure \< 80% of the baseline reading) will be managed by 5 mcg norepinephrine. if the hypotensive episode persisted for 2 minutes, another bolus of norepinephrine will be administered.

Eligibility criteria:
inclusion criteria: * adult patients (18-60 years), american society of anesthesiologist physical status i-ii, scheduled for elective non-cardiac surgery under general anesthesia exclusion criteria: * patients with cardiac morbidities (impaired contractility with ejection fraction \< 50%, heart block, arrhythmias, tight valvular lesions), patients on antihypertensive medications, and patients with uncontrolled hypertension will be excluded from the study. patient with decompensated respiratory disease (poor functional capacity, generalized wheezes, peripheral o2 saturation \< 90% on room air), patients at increased risk of aspiration (inadequate fasting time, chronic renal failure, diabetes mellitus, bmi≥40 kg/m2, gastroesophageal reflux disease, gastrointestinal obstruction, previous upper gastrointestinal surgery and/or undergoing upper gastrointestinal surgery), pregnant patients and patients with increased intracranial tension will be also excluded from the study
predictive models of treatment responses and survival outcomes in patients with soft tissue sarcoma

Conditions: Soft Tissue Sarcoma

Summary: the aim of this study was to developed and validated models to predict therapeutic responses and patients' survivals in patients with soft tissue sarcoma and compared these models with currently available models.

we performed a retrospective-prospective cohort study with the aim of developing and validating comprehensive models to predict treatment responses and survival outcomes in patients with biopsy-proven soft tissue sarcoma. secondly, we aimed to compare the predictive accuracy with currently available noninvasive model.

Eligibility criteria:
inclusion criteria: * receiving no treatment before diagnosis * with written informed consent exclusion criteria: * clinical data missing * without written informed consent
mental stress and bowel preparation quality

Conditions: Colonoscopy; Intestinal Disease

Summary: the goal of this cross-sectional study was to explore the relationship between physical and psychological stress and the quality of bowel preparation before a colonoscopy examination, in order to improve the quality of bowel preparation. the main questions it aims to answer are: does physical and psychological stress affect the quality of colonoscopic bowel preparation, and delay disease detection? how can we improve the quality of colonoscopy？ participants will be asked to complete a questionnaire containing their demographics, history of diseases and drugs, lifestyle habits, and physical and 14-item perceived stress scale(pss-14). quality of bowel preparation was assessed by the boston bowel preparation scale（bps）.

a total of 1000 patients who were to undergo colonoscopy at the endoscopy centre of the department of gastroenterology, renji hospital, from may 2023 to august 2023 were collected, and the general information and the physical and mental stress test scale of the patients were collected by questionnaires from random samples, and they were screened for enrolment according to the inclusion and exclusion criteria. the correlation between physical and mental stress and the quality of bowel preparation for colonoscopy was analyzed according to the boston rating scale (bps), which is used by colonoscopists to assess the quality of bowel preparation for each patient.

Eligibility criteria:
inclusion criteria: * participants aged 18 to 75 years old with an indication for colonoscopy * participants signed an informed consent form for colonoscopy and underwent colonoscopy * participants not be with a history of digestive tumors, active inflammatory bowel disease and other conditions that significantly affect colonic motility * participants with good communication and comprehension skills and be able to answer assessment questions accurately exclusion criteria: * withdrawal prior to colonoscopy * incomplete completion of information
the effect of motivational ınterviewing on ıntention to quit smoking in lung cancer patients

Conditions: Smoking Cessation; Motivational Enhancement; İntention to Quit

Summary: the effect of online video conferencing on smoking cessation intention in patients diagnosed with lung cancer was investigated.


Eligibility criteria:
inclusion criteria: * patients over the age of 18, * diagnosed with lung cancer, who had smoked at least 100 cigarettes in their lifetime and had smoked at least one cigarette in the last month, * who volunteered to participate in the study, * who had no communication problems, and who had internet access were included in the study. exclusion criteria: * occasional smokers, * those using a different type of nicotine than cigarettes, * those actively participating in other smoking cessation programs, and those reporting dependence on any medication were excluded from the study.

Keywords: motivational enhancement real-time video counselling lung cancer i̇ntention to quit smoking
correlation of metamorphopsia and aniseikonia to retinal shift following retinal detachment surgery

Conditions: Retinal Detachment

Summary: individuals operated for rhegmatogenous retinal detachment will be prospectively evaluated for postoperative retinal shift. fundus autofluorescence will be used to evaluate retinal shift that will be correlated to visual acuity, metamorphopsia, aniseikonia, and stereopsis.


Eligibility criteria:
inclusion criteria: * acute rhegmatogenous retinal detachment, fovea detached, able to signe exclusion criteria: * secondary retinal detachment like tractional, serous or with ora serrata dialysis, fovea on

Keywords: retinal shift aniseikonia metamorphopsia autofluorescence
micropulse 577nm laser vs traditional laser treatment in central serous chorioretinopathy

Conditions: Central Serous Choroidopathy

Summary: the purpose of this study is to observe whether micropulse laser (mpl) is noninferiority to traditional laser therapy in central serous chorioretinopathy.

central serous chorioretinopathy (csc) is characterized by serous detachment of neurosensory retina which can cause lose in visual acuity. some studies have shown that traditional laser treatment (tlt) is effective on csc, although accompanied with side-effects, such as scar. recent retrospective studies suggest micropulse laser (mpl) therapy may also be effective without obvious complications in this disease. but to date, there is no study on effectiveness of csc between tlt and mpl. the study is the first prospective randomized controlled trial about 577nm micropulse laser versus traditional laser treatment in central serous chorioretinopathy. it is a noninferiority study. the investigators hypothesize that application of 577nm micropulse laser in patients with csc will prompt resolution of csc as measured by ocular coherence tomography and best corrected visual acuity.this will be a pilot study to establish sound methods and provide some insights to the safety and efficacy of csc treatment. the primary outcome measures is the change of bcva in 12 week.

Eligibility criteria:
inclusion criteria: 1. patients with csc； 2. age\>=18 years old; 3. duration is less than 6 months； 4. the presence of subretinal fluid(srf) involving the macula and detected by use of optical coherence tomography (oct), and crt\>=250um; 5. active leakage located at ring 2 and ring 3 (etdrs rings) on fluorescein angiography (fa). exclusion criteria: 1. patients with no case of csc； 2. patients with other macular comorbidities including but not limited to diabetic retinopathy, macular degeneration； 3. patients with prior retinal treatment less than 3 months； 4. inability to obtain photographs or to perform fa

Keywords: central serous choroidopathy micropulse laser treatment traditional laser treatment optical coherence tomography
nutritional status and asd severity of autistic spectrum disorder children in addis ababa, ethiopia; case control study

Conditions: Autistic Spectrum Disorder

Summary: the study conducts a case control analysis of the nutritional status and intake of autistic spectrum disorder diagnosed children as compared to typically developing children in addis ababa, ethiopia. it included analysis of anthropometric measurements, three days food diary food intake, urinary iodine analysis, childhood autism rating scale diagnosis, food frequency and eating behavior questioner and proximate analysis of one day major meals of selected subjects.

sample population was addis ababa city in which subjects were selected from one of the two autism centers in the country. random sampling method was applied to select subject from the total enrolled children in the center using ryan 2013 sample size calculation formula. subjects already diagnose with autistic spectrum disorder that didn't have any other chronic disease that affect diet and nutrition were included in the study. subjects were selected randomly from each grade level in the center. they were registered and taken for data collection. sample and data was collected with the help of each child's center caregiver and parent. childhood autism rating scale diagnosis, eating behavior analysis were analyzed for the asd and anthropometric indices z scores, urine iodine concentration, three days food diary analysis, major meals proximate analysis, food frequency and dietary diversity was assessed and compared to typically developing children in addis ababa. data entry and analysis was conducted using emergency nutrition assessment software, microsoft excel and statistical package for the social sciences software.

Eligibility criteria:
inclusion criteria: * children already diagnosed with asd * school aged children (4-18 years old) exclusion criteria: * children with chronic illnesses ( such as cancer..) * children taking heavy medications that may affect diet and nutrition

Keywords: autistic spectrum disorder (asd) typically developing children (tdc) nutritional status nutrient intake urine iodine autistic severity
risk of methicillin-resistant s.aureus (mrsa) infections in mrsa carrier under introduction of rapid mrsa screening

Conditions: Inflammatory Bowel Disease; Hepatobiliary Disease; Pancreas Disease

Summary: this study was designed to evaluate the effect of a targeted preoperative methicillin-resistant staphylococcus aureus (mrsa) detection by polymerase chain reaction (pcr) on either endogenous or exogenous postoperative mrsa infections in a high risk population undergoing gastroenterological surgery. the primary endpoint was to investigate whether the potentially high incidence of mrsa infections in patients with mrsa nasal colonization before surgery can be prevented with a pcr-based strategy. the second endpoint was to investigate the impact of acquisition of mrsa colonization after surgery on the occurrence of mrsa infections. investigators hypothesize that postoperative mrsa infection is prevented by a targeted screening strategy in preoperative mrsa carrier, and there is limited effect in patients with postoperative mrsa acquisition.

target screening for nasal carriage of mrsa by polymerase chain reaction (pcr) was performed before or on admission. in order to identify mrsa nasal acquisition while on the ward, all patients who were negative before surgery were re-screened every 7 days until discharge. the inclusion criteria for screening were patients undergoing inflammatory bowel disease surgery on ward a, and those undergoing major hepato-biliary-pancreatic surgery on ward b. investigators classified enrolled patients into preoperative mrsa nasal carriage, postoperative nasal acquisition in patients who were negative for pcr assay before surgery, and non-nasal mrsa carriage during hospitalization. development of postoperative infections caused by mrsa was assessed according to the nasal mrsa carriage status. mrsa infections rate was also compared between the 2-years of the intervention period and the previous 2-year control period on each ward. control measures in identified mrsa carriers consisted of contact precautions, antibiotic prophylaxis with a single dose of vancomycin 1g in addition to cephalosporins, and topical decolonization of mrsa (application of 2% mupirocin ointment twice daily to nares for 5 days and a bath with 4% chlorhexidine daily for 3-5 days). although contact precautions were used when caring for mrsa-colonized patients, isolation/cohorting was not routinely practiced.

Eligibility criteria:
inclusion criteria: * patients undergoing inflammatory bowel disease (ibd) surgery * patients undergoing major hepato-biliary-pancreatic surgery exclusion criteria: * emergency surgery, * age less than 18 years old * known allergy to mupirocin or chlorhexidine.
a study to determine the effectiveness and tolerability of mk8141 in patients with high blood pressure (mk-8141-006)

Conditions: Hypertension

Summary: this study will evaluate the effectiveness and tolerability of mk8141 in lowering blood pressure in patients who have hypertension (high blood pressure).


Eligibility criteria:
inclusion criteria: * you are 35 to 65 years of age * in the past 14 days you have not been treated for hypertension * in the past 14 days you have not taken more than 2 medications to treat high blood pressure * you are a woman who is not able to have children or do not use birth control exclusion criteria: * you are taking more than 2 medications to treat high blood pressure * you have a history of a stroke, transient ischemic attack (tia), heart attack, congestive heart failure, coronary artery bypass surgery * you have type 1 or 2 diabetes mellitus * you have an active liver disease, gallbladder disease, or bowel disease * you are hiv positive * you have certain types of cancer * you abuse drug or alcohol * you have participated in another clinical study in last 4 weeks
effectiveness of an integrated care program on asthma control and inhaled corticosteroids adherence

Conditions: Asthma

Summary: the investigators propose to implement and evaluate an integrated care program for enhancing the care of patients with asthma in a region of quebec province, canada. the investigators will implement our intervention in a family medicine group practice setting and plan to deliver it to 150 experimental group subjects. the investigators will simultaneously study 300 control subjects who are receiving usual care in other regions of the province of quebec. our hypothesis is that the program will improve the quality of life of patients with asthma exposed to the program, asthma control, inhaled corticosteroid adherence, knowledge of asthma, and a number of variables that relate to the conceptual model selected as a framework for this study (the precede-proceed model of green and kreuter).


Eligibility criteria:
inclusion criteria: individuals aged 12 to 45 years, for whom the pharmacists had dispensed at least one anti-asthma drug in the previous six months were screened and randomly contacted by phone. those who reported an asthma diagnosis and who were using a short-acting beta-2-agonist (saba) \>3 times a week (except before exercise) or a corticosteroid (inhaled or oral), irrespective of frequency were included. exclusion criteria: pregnancy, no prior asthma diagnosis, participation in an ongoing respiratory study, or another respiratory illness.

Keywords: asthma intervention medication adherence inhaled corticosteroids asthma control integrated care