Kornimate/medical-research-clean huggingface dataset:
long term predictors of graft patency after coronary artery bypass graft surgery (multi-slice ct coronary angiography study validated by coronary angiography)

Conditions: Coronary Artery Disease

Summary: to detect and evaluate the predictors of graft patency after coronary artery bypass graft surgery as assessed by multi-slice ct coronary angiography validated by coronary angiography

coronary artery bypass grafting (cabg) is an effective treatment of complex, multi-vessel coronary artery disease(1) .the majority of these patients receive left internal mammary artery (ima) grafts to the left anterior descending (lad) coronary artery and saphenous vein grafts (svgs) or other conduits to the remaining vessels. based on small studies of selected groups of patients, it is generally believed that svgs have a 40% to 50% 10-year patency and that the lima has a 90% to 95% 10-year patency the success of coronary artery bypass grafting (cabg) is dependent on the long-term patency of the arterial and venous grafts.(2) graft failure is a surrogate marker for future cardiac events, including repeat revascularization, myocardial infarction ,and death(3)(4). vein graft occlusion in the perioperative period is due to thrombosis resulting from technical problems. vein graft occlusion within the first year is attributed to intimal proliferation, although after 1 year, atherosclerosis is thought to be the dominant factor (5) . lima graft failure was defined as diffuse and \>95% conduit narrowing ("string sign" when ima graft failure occurs, technical error is the most common cause in the early postoperative period, while late (and rare) ima failure include progressive fibro-intimal proliferation and atherosclerosis either in the ima graft or in the native lad vessel)(6) traditionally, graft patency has been evaluated with coronary angiography (ica) but, since the advent of multi-detector computed tomography (mdct), the temptation to use a noninvasive and widely available technique to study coronary artery bypass graft (cabg) patients has been stronger. the introduction of scanners like 64-slice and 128-slice upwards-along with new scan protocols opens new perspectives in non-invasive assessment of graft patency.(7) the pooled sensitivity and specificity of detecting complete graft occlusions - according to( barbero et al ,2016) ,was 99% and 99% respectively as compared to the standard of coronary angiography. (8) computed tomographic angiography, labeled as appropriate test for evaluation of bypass grafts and coronary anatomy (9)

Eligibility criteria:
inclusion criteria: * all patients underwent coronary artery bypass graft surgery more than one year ago complaining of chest pain are included in the study from september 2017 to september 2018 * written consent, free and informed exclusion criteria: * • renal insufficiency (serum creatinine \>1.6 mg/dl). * contrast hypersensitivity. * irregular heart rhythm (e.g. atrial fibrillation). * inability to hold breath for at least 10 seconds
quetiapine fumarate as monotherapy in the maintenance treatment of patients with major depressive disorder

Conditions: Major Depressive Disorder

Summary: the purpose of this study is to determine safety \& efficacy of seroquel sr™ in the treatment of major depressive disorder compared to placebo \& to evaluate quality of sleep, overall quality of life, and effect, if any, on anxiety and satisfaction please note: seroquel sr and seroquel xr refer to the same formulation. the sr designation was changed to xr after consultation with fda.


Eligibility criteria:
inclusion criteria: * documented clinical diagnosis according to the dsm-iv (diagnostic and statistical manual of mental disorders, 4th edition, text revision) meeting criteria 296.2x major depressive disorder, * single episode, or 296.3x major depressive disorder, exclusion criteria: * patients with a dsm-iv axis i disorder other than mdd w/in 6 months of enrollment, * patients with a diagnosis of dsm-iv axis ii disorder which has a major impact on the patients current psychiatric status. * patients whose current episode of depression\>12 months or \<4 weeks from enrollment

Keywords: seroquel sr™ major depressive disorder
proof of concept of vly-686 in subjects with treatment-resistant pruritus associated with atopic dermatitis

Conditions: Treatment-resistant Pruritus Associated With Atopic Dermatitis

Summary: this is randomized, double-blind, placebo-controlled study to test whether vly-686 can reduce chronic pruritus in subjects with treatment-resistant pruritus associated with atopic dermatitis in comparison with placebo.


Eligibility criteria:
inclusion criteria: * men and women ages 18 - 65 years, inclusive; suffering from atopic dermatitis with a scorad index at inclusion ≤80; with atopic lesions on arms, legs, trunk and neck; * chronic pruritus with pruritus being actively present for at least 6 weeks prior to screening; * males, non-fecund females, or females of child-bearing potential using 2 independent highly effective barrier methods of birth control when used correctly for a period of 35 days before the first dosing, during the study and for one month after the last dose and must have a negative pregnancy test at the screening and baseline visits. exclusion criteria: * chronic pruritus due to conditions other than atopic dermatitis (ad) including the following conditions: prurigo nodularis, lichen simplex chronicus, bullous pemphigoid; * acute superinfection of ad.

Keywords: pruritus atopic dermatitis vly-686
acupuncture as migraine prophylaxis in reducing frequency, duration and intensity of migraine with minimum acupoint, seen up to eight weeks from baseline

Conditions: Migraine; Headache; Migraine Disorders

Summary: migraine is a primary headache attack, specific, paroxysmal, with or without aura, with subjective manifestations both before and after the attack, a chronic type of headache with symptoms of recurrence, attacks at productive age and can cause a decrease in work productivity up to 80%, so that it will affect the quality of life, economic life and education globally which leads to losses for migraine sufferers and institutions where migraine sufferers attend school, work and in the lives of sufferers' families.

migraine is a primary headache attack, specific, paroxysmal, with or without aura, with subjective manifestations both before and after the attack, a chronic type of headache with symptoms of recurrence, attacks at productive age and can cause a decrease in work productivity up to 80%, so that it will affect the quality of life, economic life and education globally which leads to losses for migraine sufferers and institutions where migraine sufferers attend school, work and in the lives of sufferers' families. with the high prevalence and disability rates for migraine sufferers, on the other hand, the right treatment for migraine has not yet been obtained to the maximum, it is necessary to deepen the treatment and prevention of migraine is needed, and until now there has been no definitive cure, both for prevention and treatment, so it is necessary to develop therapies that can provide more accurate relief for migraine sufferers. the purpose of this study is to assess the success in managing migraine in reducing the frequency of attacks, reducing the intensity of attacks and reducing the duration of attacks from weeks 0, 4 to 8

Eligibility criteria:
inclusion criteria: * subjects aged 19-50 years * subjects with history of clinical diagnosis of migraine (interictal period) * signed research approval forms, and were willing to take the study to completion. exclusion criteria: * subjects with pregnancy, * lesions, wounds, infections and suffering from malignant diseases or tumor and thrombophlebitis in the area at the selected acupuncture point * increasing liver function three times above normal values.

Keywords: migraine acupuncture visual analogue scale headache
quality of life after biliodigestive anastomosis (bda) or stents to treat biliary obstruction in pancreas cancer

Conditions: Local Tumor Spread; Advanced Cancer; Metastasized; Pancreatic Cancer Non-resectable; Jaundice

Summary: to compare the quality of life (qol) in patients receiving a bilioenteric anastomosis vs. endoscopical stenting for palliation of biliary obstruction due to locally unresectable or metastatic pancreatic cancer. in the past, endoscopy seems to have been favoured based on older studies, but with new chemotherapeutic regimens available, the likelihood to experience stent complications has increased. therefore, the issue as to which palliation should be favoured has to be reconsidered.

the aim of this multi-centre, prospective-randomised study was to compare the effectiveness of palliative applications on patients suffering from a local, advanced and/or hepatic, metastasising, non-resectable pancreas head carcinoma and jaundice. before randomisation, all patients are fitted with an endoscopically inserted biliary tract drainage endoscopically inserted. when postoperatively ascertained that the pancreas head carcinoma is non-resectable, the patient shall be electronically registered and randomly assigned to one of the palliative strategies. group 1 will be fitted with a biliodigestive anastomosis. group 2 will continue with the endoscopically inserted drainage. regardless of which group they belong to, all patients will receive a palliative chemotherapy. the primary parameter is the average quality of life over a period of 6 months post-operatively, to be analysed monthly using identical questionnaires. the comparison of the randomisation groups will be carried out using a co-variance analysis (ancova) with the initial value, taken directly before the operation, to be used as co-variant.

Eligibility criteria:
inclusion criteria: 1. adult patient with local, advanced adenocarcinoma of the pancreas head and jaundice. 2. performance-status of 50 or above on the karnofsky-scale (see attachment). 3. adequate bone marrow reserves: leukocyte level \> 3.5 x 10´/l, thrombocyte level level \> 100 x 10/l; haemoglobin\> 80g/l. 4. male or female patients, at least 18 years old. 5. women of child bearing age must be sufficient protected against pregnancy (contraception) during and for 3 months after the end of the study. exclusion criteria: 1. adult patients with focal, advanced adenocarcinoma of the pancreas head and no jaundice; also no jaundice in their anamnesis and with no endoscopic retrograde cholangio-pancreaticography (ercp)-induced intervention. 2. pregnancy 3. breast feeding 4. contra-indication for gemcitabine

Keywords: advanced, metastasising pancreatic head carcinoma jaundice biliodigestive anastomosis endoscopically inserted biliary tract drainage quality of life
the role of regulatory t cell in patients with type 1 diabetes mellitus

Conditions: Type 1 Diabetes Mellitus

Summary: evaluate the regulatory t cell function in patients with type 1 diabetes mellitus, and find the pathogenesis of this autoimmune disease.

type 1 diabetes mellitus (t1d) is an autoimmune disease characterized with t cell mediated destruction of pancreatic βcell. dysregulated b and t cells were reported in the animal model. the loss of maintenance of immune homeostasis is thought to be major mechanism and result in persistence of autoreactive t cell in the periphery. therapies which modulate the immune dysfunction may be helpful for the patients of t1d. immune homeostasis means a balance between the responses that control infection and tumor growth and reciprocal responses that prevent inflammation and autoimmune disease. cd4+ cd25+ regulatory t cells (tregs) are critical to maintain such functions. their actions can be through cell-to-cell contact or bystander effect. the specific markers of tregs include cd25 molecule (il-2 receptorαchain), foxp3 (forkhead-winged helix transcription factor). the foxp3 is a transcription factor that controls some genes encoding tregs associated molecules, such as cd25, ctla-4 and gitr. the previous studies of modulation of tregs in t1d show positive results in animal model. but the relative sizes of cd4+cd25+ population in human are still controversial. our hypothesis is that the imbalance of tregs and autoreactive t cells is the pathogenesis of t1d. therefore, we used flow cytometry to determine the number of cd4+cd25+ tregs population and quantitative real-time pcr to assay the expression of foxp3, clta-4, gitr in patients with different stages and normal control. besides, autoantibodies to gad65 is associated with t1d in 60-80% patients. it is a marker of autoimmune diabetes. we anticipated that the realization of tregs functions in patients of t1d will help our further guide of immunotherapy of patients with t1d and other autoimmune disease.

Eligibility criteria:
inclusion criteria: * pediatric type 1 dm exclusion criteria: -
the effect of hypertonic saline on the lung clearance index in patients with cystic fibrosis

Conditions: Cystic Fibrosis

Summary: this study is examining the effect of hypertonic saline compared to placebo on the lung clearance index in cystic fibrosis patients.

the life expectancy of patients with cystic fibrosis (cf) has greatly increased over time due to improved clinical care. while this is certainly beneficial to cf patients, the overall stability in lung function has made it more difficult to assess the effect of therapeutic interventions. currently, fev1 (forced expiratory volume in 1 second) remains the primary outcome measure for most clinical trials, but many cf patients have normal pulmonary function and the annual rate of decline is now less than 2% in large specialized centres. therefore, additional parameters are needed that are more sensitive parameters to define abnormalities in cf patients and be used in therapeutic trials. one such promising parameter is the lung clearance index (lci). the lci is a test to quantify ventilation inhomogeneity by assessing the washout of an inhaled inert gas. abnormalities in gas clearance from the lung are largely due to retention of inhaled gases due to mucous obstruction in the lower airways. interventions that improve mucus accumulation are expected to improve the lci. hypertonic saline has been shown to increase airway surface liquid (asl), mucociliary clearance and pulmonary function. therefore, this study will examine the effect of hypertonic saline compared to placebo on the lung clearance index in cystic fibrosis patients.

Eligibility criteria:
inclusion criteria: * diagnosis of cf as defined by two or more clinical features of cf and a documented sweat chloride \> 60 meq/l by quantitative pilocarpine iontophoresis test or a genotype showing two well characterized disease causing mutations * informed consent and verbal assent (as appropriate) provided by the subject's parent or legal guardian and the subject * 6-18 years of age at enrolment and able to perform reproducible spirometry * clinically stable at enrolment * fev1 % predicted ≥ 80 % as calculated by the wang reference equations * ability to comply with medication use, study visits and study procedures exclusion criteria: * respiratory culture positive for ntm or b. cepacia complex within past year or screening * use of intravenous antibiotics or oral quinolones within 14 days of screening * investigational drug use within 30 days of screening * physical findings at screening that would compromise the safety of the participant or the quality of the study data

Keywords: cystic fibrosis lung clearance index hypertonic saline pediatrics
duration of postop analgesia after inguinal hernia surgery treated with tap block vs ii/ih nerve block

Conditions: Postoperative Analgesia

Summary: comparing postop analgesia after inguinal hernia surgery treated with tap block vs ilioinguinal/ iliohypogastric nerve block

comparison of mean duration of postoperative analgesia in patients undergoing inguinal hernia surgery treated with transversus abdominal plane block versus ilioinguinal/ iliohypogastric nerve block

Eligibility criteria:
inclusion criteria: * patients giving written informed consent * patients undergoing inguinal hernia surgery * patients with ages 18-60 years * asa 1 and 2 patients exclusion criteria: * inr \> 1.0 (patients with bleeding tendency) * ef \< 45 % (patients with cardiac dysfunction) * fev1 \< 80 % of normal (patients with pulmonary dysfunction) * patients with renal disease

Keywords: postop analgesia postoperative analgesia tap block transversus abdominis plane block ilioinguinal/ iliohypogastric nerve block ilioinguinal/iliohypogastric nerve block inguinal hernia surgery abdominal nerve block nerve block nerve blocks bupivacaine ultrasound guided nerve block ultrasound guided nerve blocks 0.25% bupivacaine 0.25 percent bupivacaine hernioplasty internal oblique transversus abdominis iin ihn iin/ ihn ii/ ih nerve block transversus abdominis muscle ilioinguinal muscle iliohypogastric muscle
modulation of the gut microbiota and metabolism in elderly by algae products.

Conditions: Frailty

Summary: the goal of this clinical trial is to determine whether a fermented black soybean and adlay supplement can improve frailty. the main questions it seeks to answer are: * does the fermented black soybean and adlay supplement improve physical performance? * what is the effect of the fermented black soybean and adlay supplement on gut microbiota? researchers will compare the fermented black soybean and adlay supplement to a placebo (a non-fermented black soybean and adlay supplement) to assess its impact on physical performance. participants will: * take either the fermented black soybean and adlay supplement or a placebo daily for 12 weeks. * visit the clinic for checkups and tests before and after consuming the product.

this study aims to evaluate the effects of fermented black soybean and adlay supplements on frailty and gut microbiota in older adults. older participants are recruited from national taiwan university hospital. parcitipants will be stratified randomization into placebo and experimental groups based on their robustness status. older participants will take either the fermented black soybean and adlay supplement or a placebo daily for 12 weeks. baseline characteristics of the participants, including demographic data, chronic disease history, and anthropometric data, will be collected. cognitive function will be evaluated using the mini-mental status examination. a 15-item version of the geriatric depression scale will be used to identify depressive symptoms. nutritional status will be assessed with the mini nutritional assessment. blood and fecal samples, as well as data on physical performance and frailty status, will be collected before and after consuming the product.

Eligibility criteria:
inclusion criteria: * age 65 years or older * independent in activities of daily living exclusion criteria: * being bedridden or residing in a nursing home * having a life expectancy of less than 6 months * having severe hearing or communication disorders * having hyperuricemia, gouty arthritis, or swallowing dysfunction

Keywords: frailty black soybean adlay fermentation gut microbiota
study on the treatment of degenerative lumbar spine stenosis with a percutaneous interspinous implant

Conditions: Lumbar Spinal Stenosis

Summary: neurogenic intermittent claudication is a specific symptom complex occurring in patients with lumbar spinal stenosis. characteristic of this disease is the occurrence of increasing leg, buttock or groin pain with or without lower back pain when walking a certain distance or reclining. bending forward or sitting leads to a rapid pain relief. lumbar spinal stenosis is defined as a reduction of the diameter of the spinal canal. the mechanism leading to stenosis is a remodeling and overgrowth of the spinal canal with osteophyte formation. any loss of tissue or decrease of the disc height results in a relative laxity of the ligament structures and accelerates the degeneration of the spinal joints. as a therapy option, conservative therapy with oral analgesics and physical therapy is considered. this treatment can be intensified by adding epidural pain treatment. is the conservative treatment not successful surgical intervention is necessary. in patients over 65 years of age operative decompression of the lumbar spinal stenosis constitutes the most common surgical operation of the spine. a relatively new therapy alternative is the interspinous process decompression (ipd). studies have shown that the ipds prevent narrowing of the spinal canal and neural foramens. the study is intended as a randomised, monocentre study to investigate the safety and the benefit of a minimally invasive percutaneous ipd-device in comparison with the best non-surgical operative treatment of lumbar spinal stenosis.


Eligibility criteria:
inclusion criteria: 1. male or female over 50 years of age 2. one, two, or three segment degenerative lumbar spinal stenosis (dlss) 3. symptoms of radiographically confirmed dlss like leg, buttock, or groin pain with or without back pain and absence of a peripheral motoric deficit 4. pain relief in inclination or sitting 5. ability to walk over a distance of 50 m 6. unsuccessful conservative therapy for 3 months under outpatient conditions 7. informed consent exclusion criteria: 1. fixed motoric deficit 2. cauda equina syndrome 3. previous surgery of the lumbar spine 4. severe osteoporosis of the vertebrae and/or of the hip 5. spondylolisthesis more severe than meyerding i (on scale of i-iv) 6. metastasis of the vertebrae 7. mentally disabled persons

Keywords: pidlss, spacer
lung and diaphragm ultrasound evaluation during weaning from mechanical ventilation in covid-19 patients

Conditions: Weaning; COVID-19; Lung Ultrasound; Diaphragm Ultrasound

Summary: the goal of this observational study is to learn about the function of lung and diaphragm ultrasound during weaning from mechanical ventilation in covid-19 patients. the aim of this study was that the lung ultrasound score and diaphragm muscle mobility could be a potential predictive factor of weaning success.


Eligibility criteria:
inclusion criteria: * age \> 18 years, * critically ill patients with covid-19 (defined as those requiring mechanical ventilation due to respiratory failure), and eligible for their first sbt according to the attending physician's judgement that the underlying disease which led to intubation had sufficiently resolved. exclusion criteria: * patients with previous cardiothoracic surgery or pleurodesis and patients who presented with stridor (due to upper airway involvement) as a cause of extubation failure * neuromuscular disease