Kornimate/medical-research-clean huggingface dataset:
bayesian sequential single case methods to personalize low-intensity psychological interventions: initial pilot work

Conditions: Depression

Summary: the study is an initial investigation of the feasibility of applying bayesian sequential analyses to individual participant single-case data for rapid detection of whether or not the individual is benefitting from a low-intensity computerized cognitive training intervention for depression. patients waiting for, or in follow-up from, outpatient psychological therapy will complete first a two-week period of daily symptom monitoring, followed by two different two-week cognitive training interventions. data collected will be used to assess feasibility of a future formal case series using bayesian sequential analyses to determine switching of interventions, and inform the analysis parameters for such a future study.


Eligibility criteria:
inclusion criteria: * patient registered at the ruhr university of bochum outpatient psychotherapy center ("zentrum für psychotherapie", zpt) in an appropriate phase of treatment (on waiting list/ in follow-up), or from 26/10/22 having had a first consultation ("beratungsgespräch") * aged 18 years or above * owning a technical device (e.g. a laptop, computer) that is compatible with the computerized training * scoring ≥ 6 on the qids (indicating at least mild levels of depressive symptoms) * willing and able to complete all study procedures exclusion criteria: * existence of a condition or circumstances that would interfere with completion of the study procedures (e.g. severe visual impairment, neurological problem, acute psychosis, or substance withdrawal symptoms) * acute crisis with high levels of suicidal ideations or high levels of self-harm, identified either through therapist's assessment or score \>1 on item 12 of the qids

Keywords: depression anhedonia cognitive bias modification cognitive control training bayesian sequential analyses single case series
effect of scoliosis-specific exercise on lower limb biomechanics

Conditions: Scoliosis Idiopathic

Summary: purpose: to examine the effect of physiotherapeutic scoliosis-specific exercise on limb biomechanical parameters in adolescents with idiopathic scoliosis. a randomised controlled trial background: adolescent idiopathic scoliosis is one of the most common orthopaedic diseases affecting the spine during adolescence. the efficacy of exercise treatment is controversial. although evidence suggests that psse, which include auto-correction in 3d, integration in daily life, stabilizing the corrected posture, and patient education, could improve some outcomes, effect of psse on related biomechanical alterations in lower limbs have not yet been examined. hypotheses: null hypothesis there are no statistically significant effect of physiotherapeutic scoliosis-specific exercise on lower limb biomechanics in scoliotic adolescents. research question: what are the effect of physiotherapeutic scoliosis-specific exercise on lower limb biomechanics in scoliotic adolescents.?

procedures: a randomized controlled clinical trial will be conducted assessment: x-ray computed scanogram radiography of the whole spine and both lower limbs in standing will be used. the following measurements will be taken pre and post the treatment program: for the lumbar spine coronal alignment: 1. cobb's angle for dorso-lumbar scoliosis (curve apex from d10- l4) will be measured. 2. coronal balance estimated by the distance between plumb line and central sacral line from anterioposterior x-ray view for both lower limbs: 1. the length will be measured for the limb, the tibia and the femur 2. tibiofemoral angle 3. joint line convergence angle 4. mechanical axis 5. mechanical axis deviation treatment: patients will be randomly assigned into two groups to receive the prescribed treatment program for 6 months., 1 session per week in addition to a home program of daily exercise . the control group will receive the standard care composed of trunk muscles strengthening exercises, trunk proprioception exercises . the experimental group will receive the same standard treatment in addition to physiotherapeutic scoliosis-specific exercise data will be analyzed using 2 way manova.

Eligibility criteria:
inclusion criteria: * adolescents with age 10-18 years * complaining of dorsolumbar scoliosis * curves (apex lies between d10 and l4) * curve magnitudes greater than 15 degrees and less than 90 * using or not using brace * all maturity levels (risser = 0-5) exclusion criteria: * other types of scoliosis ; congenital or neuromuscular * current physical therapy or medical treatment for scoliosis, * contracture or surgery affecting the lumbar spine or lower limbs * pathologies such as inflammatory diseases * congenital anomalies * neurological disorders like cerebral palsy or ataxia * dislocations * visual or auditory problems

Keywords: scoliosis exercise lower limb biomechanics
using the musical track from gc-mrt as a treatment booster in stressful situations

Conditions: Social Anxiety

Summary: the study examines whether musical tracks played during gaze contingent music reward therapy (gc-mrt) for social anxiety could later be used as a booster to reduce anxiety before a stressful situation. to this end, highly socially anxious participants will undergo 4 gc-mrt sessions designed to train participants' attention away from threat and towards neutral social stimuli. subsequently, participants will be asked to perform a socially stressful speech task. prior to the speech, half of the participants will listen to a musical track the participants were trained with, and half of the participants will listen to a musical track the participants like but were not trained with during the gc-mrt sessions. the investigators expect that listening to musical track taken from the gc-mrt sessions will moderate the increase in anxiety levels prior to the speech and will improve performance during the speech compared to a non-trained musical track.

gaze contingent music reward therapy (gc-mrt) is designed to modify threat-related attention biases through operational conditioning between beloved music and gaze patterns favoring neutral stimuli over threat-related stimuli. gc-mrt has shown efficacy in reducing social anxiety symptoms. the current study is designed to explore whether the musical tracks played during the gc-mrt conditioning could be later used as a treatment booster to reduce anxiety in a socially stressful situation. to this end, 60 high socially anxious participants will undergo four gc-mrt sessions and then will be asked to perform a stressful speech task. prior to the speech, half of the participants (randomly determined) will listen to a musical track the participants were trained with, and half of the participants will listen to a musical track the participants like but were not trained with during gc-mrt sessions. the investigators expect that the listening to musical track taken from the gc-mrt sessions will moderate the increase in anxiety levels prior to the speech and will improve performance during the speech compared to a non-trained musical track.

Eligibility criteria:
inclusion criteria: * a signed consent form * an age of 18 years or above * a score greater than 60 on lsas exclusion criteria: * a self-reported history of neurological or psychiatric illness
evaluation of deterioration in body posture of older patients during gait compared to stance

Conditions: Degenerative Spine Disease; Sagittal Balance

Summary: the goal of this observational study is to analyze how spinal alignment changes when walking compared to standing still in adults aged 50 to 80 years who have sagittal imbalance. the main questions we aim to answer are: 1. do patients with radiological parameters indicative of sagittal imbalance experience a statistically significant deterioration in sagittal balance during walking compared to a control group? 2. do radiographs taken after six minutes of walking provide comparable results to dynamic measurements during the walking test? 3. do patients with a greater deterioration in sagittal balance during walking show poorer clinical self-assessment scores? 4. is there a significant correlation between parameters obtained using established diagnostic methods and the degree of sagittal balance deterioration during walking? participants will be divided into two groups: patients with radiological indicators of sagittal imbalance and a control group of healthy individuals with back pain of similar age. participants will: 1. complete questionnaires about their back pain and mobility. 2. have x-ray images taken of their spine before and after walking for six minutes. 3. undergo muscle strength tests and gait analysis using motion capture and electromyography (emg) to monitor muscle activity while walking.


Eligibility criteria:
inclusion criteria: * pelvic incidence-lumbar lordosis deficit (pi-ll) greater than 10 or sagittal vertical axis (sva) greater than 4 centimeters * the main symptom is low back pain * age between 50-80 years. exclusion criteria: * symptoms of spinal stenosis * previous instrumented spinal surgery * cobb angle greater than 30° * symptoms of hip or knee arthrosis * symptoms of vascular intermittent claudication * cardio-pulmonary disease that lowers the patient's physical capability * neuromuscular disease
study of trifluridine/tipiracil (tas-102) in patients with metastatic colorectal cancer in asia

Conditions: Colorectal Cancer

Summary: to compare the effects of tas-102 with placebo in patients with metastatic colorectal cancer refractory or intolerable to standard chemotherapies.

this is a multinational, double-blind, two-arm, parallel, randomized phase 3 comparison study evaluating the efficacy and safety of tas-102 versus placebo in patients with refractory metastatic colorectal cancer. patients will be randomly assigned (2:1) to tas-102 (experimental arm) or placebo (control arm).

Eligibility criteria:
inclusion criteria: * has provided written informed consent * has adenocarcinoma of the colon or rectum * has failed at least 2 prior regimens of standard chemotherapies for metastatic colorectal cancer * eastern cooperative oncology group (ecog) performance status of 0 or 1 * is able to take medication orally * has adequate organ function (bone marrow, kidney and liver) * women of childbearing potential must have a negative pregnancy test and must agree to adequate birth control if conception is possible. males must agree to adequate birth control.
safety and efficacy study of mk0974 in the acute migraine (0974-016)

Conditions: Migraine

Summary: the purpose of this study is to investigate the efficacy and safety of mk0974 compared to a placebo for acute migraine.


Eligibility criteria:
inclusion criteria: * patient has at least 1 year history of migraine (with or without aura) * females of childbearing years must use acceptable contraception throughout trial exclusion criteria: * patient is pregnant/breast-feeding (or is a female expecting to conceive during the study period) * patient has history or evidence of uncontrolled diabetes, or human immunodeficiency virus (hiv) disease. patient has uncontrolled cardiovascular disease * patient has major depression, other pain syndromes that might interfere with study assessments, psychiatric conditions, dementia, or significant neurological disorders (other than migraine) * patient has a history of gastric or small intestinal surgery or has a disease that causes malabsorption * patient has a history of cancer within the last 5 years
effects of home-based surface electrical stimulation for patients with cervical myofascial pain syndrome

Conditions: Myofascial Pain Syndrome of Neck

Summary: the aim of this study is to compare the developed home-based surface electrical stimulation program to the controls in computer office workers with mps.

cervical myofascial pain syndrome (mps) is a common problem among workers who have large amount of computer use. additionally, owing to the high workload and long hours of staying in thier cubicle, the office employees are often unable to have extra time to receive rehabilitation and treatment regularly. a home-based surface electrical stimulation (ses) program is developed to help intervention be time-saving and more accessible for office-based staff busy at work. in this single-blind randomized controlled trial, participants will be assigned to one of the following three groups and undergo 3 weeks (20 minutes/ time, three times/ week) of intervention: 1. ses combined with telemedical support 2. ses 3. no intervention the outcome assessments will be performed before and after the intervention (0-wk and 4-wk) and 4 weeks after the endpoint of intervention (8-wk). the outcome assessor was blind to the intervention and group allocation.

Eligibility criteria:
inclusion criteria: * time of using computer \> 4hrs/day * neck pain \> 2 months * diagnosis of cervical myofascial pain syndrome * vas pain ≥ 3 (0\~10) exclusion criteria: * had a history of neck surgery * pregnancy * systematic disease (e.g. autoimmune disorders, arthritis, infection, etc.) * malignancy * neurological signs such as radiating pain, motor weakness in the upper extremities. * skin defect or scars at the planned placement of ses * pacemaker user * history of seizure attack * history of diabetes * fear of receiving ses

Keywords: myofascial pain syndromes surface electrical stimulation remote medical support telemedicine
mk0524a phase iib study (0524a-011)(completed)

Conditions: Flushing

Summary: part a: this study will determine that mk0524 is well tolerated and does not effect lipids and blood glucose when given alone. part b: determine dose ranges for mk0524 and mk0524 plus niaspan(r) on the effects of lipids and blood glucose.


Eligibility criteria:
inclusion criteria: * men and women, 18 to 70 years of age for whom treatment with niacin would be appropriate but who are not taking \> 50mg at screening * must be willing to complete electronic diary exclusion criteria: * subject is having menopausal hot flashes and/or receiving hormone replacement therapy (hrt) * you have a history of cancer, gout, peptic ulcers, diabetes, liver, heart disease or high blood pressure or you are hiv positive * you consume more than 14 alcoholic drinks per week or more than 2 drinks per day
alterations in quality of life after thyroidectomy for benign thyroid disease

Conditions: Benign Thyroid Nodule; Quality of Life

Summary: to detect any changes in quality of life in patients with benign thyroid diseases who undergo thyroidectomy compared to patients with benign thyroid diseases and conservative treatment and healthy subjects.

benign thyroid diseases are a common public health problem. it has been reported that thyroid diseases can affect quality of life (qol), but this is not easy to be assessed. therefore, a valid instrument is necessary. such an instrument is thyroid-related patient-reported outcomes questionnaire (thypro). thypro has been recently translated and validated in greek language. the questionnaire consists of 85 items grouped in 14 scales concerning goiter, hypothyroidism, hyperthyroidism and eye symptoms, tiredness, cognitive impairment, anxiety, depression, emotional susceptibility, cosmetic complaints and impaired social, and daily and sex life, as well as overall quality of life. a few studies have demonstrated that various thyroid therapies may improve some aspects of qol. the aim of the present study is to address the impact of thyroidectomy in qol in patients with benign thyroid diseases.

Eligibility criteria:
inclusion criteria: 1. patient is over 18 years old 2. patient scheduled for a non-emergency operation 3. patient diagnosed with benign thyroid disease exclusion criteria: 1. patient is participating in another clinical trial which may affect this study's outcomes 2. patient with thyroid cancer 3. previous operation at the thyroid and parathyroid glands or neck irradiation 4. patient unable to read and write in greek
integrated platform for measuring and reducing symptoms of autism spectrum disorder

Conditions: Autism Spectrum Disorder

Summary: this study will consist of a randomized, double-blind, sham-controlled clinical trial at suny upstate medical university with 40 autistic children evaluating the effects of transcranial photobiomodulation (tpbm) on multiple clinically validated scales.

the proposed intervention will noninvasively deliver near infra-red (nir) light - transcranial photobiomodulation (tpbm) - to the brains of autistic children. the nir light is delivered to specific brain areas by cognilum, a wearable device developed by jelikalite. the cognilum system is a non-invasive headband medical device specifically designed to safely and comfortably deliver tpbm to autistic children. cognilum has been designated as a non-significant risk breakthrough device by the food and drug administration. this study will consist of a randomized, double-blind, sham-controlled clinical trial at suny upstate medical university with 40 autistic children using cognilium device and measuring the impact using multiple clinically validated scales. hypothesis 1: significant reduction of average childhood autism rating scores (cars; before and after treatment comparison) in the active group compared to sham-control group. hypothesis 2: significant change in average scores (before and after treatment comparison) on the social responsiveness scale (srs), and clinical global impression - improvement (cgi-i) scale in the active group compared to sham control group.

Eligibility criteria:
inclusion criteria: * ages 2 - 8 * autism spectrum disorder diagnosis * cars-2 score of 30 - 45 exclusion criteria: * cars scores less than 30 or over 45. * taking psychotropic medications. * having skin lesions on scalp * having history of seizures * having history of abnormal eeg * being a relative of the pi or a researcher * having implanted devices (including cochlear implants).

Keywords: transcranial photobiomodulation autism spectrum disorder
yoga for adolescent and young adult non-curative cancer patients

Conditions: Advanced Cancer

Summary: adolescents and young adults who are living with cancer are not benefiting from the same age-appropriate physical and psychosocial care, as are children and older adults. as a result, their unique needs often go unmet or unaddressed. studies have demonstrated that a lack of age-appropriate care may be responsible for a deceased quality of life. studies have also shown that physical activity is able to reduce many of the negative side-effects linked to cancer and its treatment (e.g., nausea, vomiting, fatigue). a light form of physical activity that is both safe and manageable for cancer patients is yoga. the purpose of this study is to examine the achievability and safety of a light 7-week home/hospice-based hatha yoga program (available on dvd) in the adolescent and young adult non-curative cancer population. this study will also examine the ability of yoga to reduce cancer related side effects.


Eligibility criteria:
inclusion criteria: * diagnosed with a non-curative cancer and assigned to non-curative or palliative care * between 15-39 years of age * have primary physician/oncologist consent to participate exclusion criteria: * experience any medical conditions that contraindicate yoga (e.g., bone metastases) * exhibit cognitive limitations (e.g., psychiatric disorders) * score below 30% on palliative performance status scale

Keywords: cancer adolescent and young adult exercise physical activity quality of life end-of-life palliative terminal yoga alternative therapies fitness fatigue
taurine supplementation on lower extremity vasculopathy in patients with diabetes

Conditions: Taurine; Diabetes; Lower Extremity Artery Disease

Summary: diabetes has become important risk factors for threatening human life and health. lower extremity arterial occlusive are the common complications of diabetes.sulfur amino acid is the indispensable amino acid in mammals, and its metabolites include taurine, hydrogen sulfide (h2s) and sulfur dioxide (so2). taurine was first isolated more than 150 years ago from ox (taurus) bile. although the taurine can be synthesized in vivo by cysteine in the presence of cysteine dioxygenase, it is mainly acquired from dietary sources, such as eggs, meat, and seafood. h2s is a biologically relevant mediator and plays potential roles in several physiological processes and disease states in the body. h2s is synthesized from 2 sulfur-containing amino acids, l-cysteine andl-methionine, by the 3 enzymes,cystathionine-γ-lyase (cse), cystathionine-β-synthetase(cbs), and3-mercaptopyruvate sulfurtransferase (3-mst). previous studies have demonstrated that taurine and h2s may play important roles in the development of the microangiopathy and lower extremity arterial occlusive.


Eligibility criteria:
inclusion criteria: 1. male or female, age between 18-80 years old 2. type 2 diabetes exclusion criteria: 1. type2 diabetes with acute diabetic complications. 2. type1 diabetes. 3. history of cardio-cerebral vascular events, such as congestive heart failure, myocardial infarction or stroke within 3 months. 4. hypohepatia (ast or ast is twice higher than the upper limit) or history of hepatitis or cirrhosis, hepatic encephalopathy. 5. renal insufficiency (serum creatinine 1.5 times higher than the upper limit) or history of dialysis and nephritic syndrome. 6. acute infections, tumor, severe arrhythmia, mental disorders, alcohol or medicine addiction. 7. fertile woman without contraceptives. 8. any surgical or medical conditions that significantly influence absorption, distribution, metabolism or excretion of the intervention drugs. 9. allergic to or have contraindication to the intervention drugs.
the management of pilonidal wounds with acell micromatrix® and cytal® wound matrix: a case series

Conditions: Pilonidal Disease

Summary: a case series involving the concomitant use of micromatrix® and cytal® wound matrix 2-layer with standard of care negative pressure wound therapy (npwt) during the management of pilonidal wound healing.

this is a prospective case series examining the concomitant use of micromatrix® and cytal® wound matrix 2-layer with standard of care negative pressure wound therapy (npwt) during the management of pilonidal wound healing. wound healing will be evaluated at 2 weeks, 6 weeks, and 3 months. if subjects heal prior to the 3 month visit, wound healing will be documented at that visit. a maximum of ten subjects will be included in this series.

Eligibility criteria:
inclusion criteria: 1. subject has a clinical diagnosis of pilonidal disease. 2. subject is being scheduled for surgical excision of pilonidal disease. 3. subject is at least 18 years of age. 4. subject is willing and able to adhere to protocol requirements and agrees to participate in the study program and comply with the study follow-up regimen. 5. subject is willing to provide written informed consent. exclusion criteria: 1. subject has a known allergy to porcine-based materials. 2. subject is pregnant

Keywords: acell acell micromatrix® acell cytal® wound matrix urinary bladder matrix