effects of perturbation-based balance training on postural control and cortical modulation in elderly with fall risk

Conditions: Old Age; Debility; Fall

Summary: this is a single-blinded randomized controlled trial with pre- and post- measurements. forty community-dwelling elderly (age\> 65 y/o) with fall risk (defined as functional reach test≦25.4 cm) will be recruited and randomly assigned to experimental group or control group (n=20 for each group). participants in the experimental group will receive the balance training under perturbation on balance systemtm sd, including limits of stability training, maze control training, random control training. the intervention is 40 min/session, 3 sessions/week for 6 weeks. participants in the control group will remain their regular activity without additional training. the primary outcomes include the limit of stability (los) of posture control by balance master® and brain modulation by event-related desynchronization (erd) collected by electroencephalogram (eeg). secondary outcomes include the sensory organization test (sot), berg balance scale (bbs), and falls efficacy scale international (fes-i).

background: falling is one of the common factors affecting the health in older people. it would cause severe consequences and result in decreasing mobility and independent activity of daily living. according to previous study, balance impairment is the frequent factor for fall in elderly. to maintain balance, reactive postural control ability is the key element from falling. it is suggested that perturbation-based balance training can improve reactive balance performance. however, few studies focus on multi-direction perturbation to mimic the perturbation experienced in daily living. furthermore, the related cortical activity changes after perturbation-based balance training is not known. purpose: the purpose of this study is to explore the effects of multi-directional perturbation-based balance training on posture control and brain modulation in elderly with fall risk. methods: this is a single-blinded randomized controlled trial with pre- and post- measurements. forty community-dwelling elderly (age\> 65 y/o) with fall risk (defined as functional reach test≦25.4 cm) will be recruited and randomly assigned to experimental group or control group (n=20 for each group). participants in the experimental group will receive the balance training under perturbation on balance systemtm sd, including limits of stability training, maze control training, random control training. the intervention is 40 min/session, 3 sessions/week for 6 weeks. participants in the control group will remain their regular activity without additional training. the primary outcomes include the limit of stability (los) of posture control by balance master® and brain modulation by event-related desynchronization (erd) collected by electroencephalogram (eeg). secondary outcomes include the sensory organization test (sot), berg balance scale (bbs), and falls efficacy scale international (fes-i). independent t test and chi-square test are used for baseline characteristic analysis. all outcomes will be analyzed by repeated measures two-way anova with tukey post hoc test for within-group and between-group comparisons. statistical significance is set at p\<0.05.

Eligibility criteria:
inclusion criteria: * over 65 y/o community-dwelling elderly with fall risk (functional reach test ≦25.4 cm). * mini-mental state examination score (mmse) ≧ 24. * able to walk independently without assistance at least 10 meters. exclusion criteria: * with any neurological, mental or cognitive disorders, and orthopedic, pulmonary or cardiac problems that could restrict or preclude their participation in exercise.

Keywords: perturbation-based balance training postural control cortical modulation elderly