Kornimate/medical-research-clean huggingface dataset:
indications of erector spinae plane block in pediatric patients

Conditions: Postoperative Pain

Summary: patients who were operated by department of pediatric surgery between the 1 september 2017 and 28 february 2019 and who received erector spinae plane blocks as a part of postoperative analgesia management will be scanned.

there are a few randomized prospective studies of espb for its clinical effectiveness and all of them are in adults, except one. also pediatric case reports are limited when compared to adults. we have been applying espb to our patients almost since from its first definition. but espb applications for pediatric patients, in our clinic, have started after a learning curve. patients who were operated by department of pediatric surgery between the 1 september 2017 and 28 february 2019 and who received erector spinae plane blocks as a part of postoperative analgesia management will be scanned. demographical data of the patient, patient position for the block, indication/surgery type, level of espb, unilateral or bilateral application, total volume applied, additional analgesic use, type of the analgesic if used will be investigated.

Eligibility criteria:
inclusion criteria: * patients who were operated by department of pediatric surgery exclusion criteria: * incomplete patient forms

Keywords: erector spinae plane block postoperative pain pediatric patients
mindfulness app versus mindfulness-based intervention for healthcare students

Conditions: Students

Summary: the main purpose of this study is to compare the efficacy of a mindfulness-based training app ('rem volver a casa') versus a regular, presence-based program (mbsr) on the reduction of anxiety and other factors related to the physician-patient relationship, in healthcare grade students.

healthcare students suffer from higher levels of anxiety and depression than the general population. it compromises not only their mental health, but also the quality of care provided. aptitudes such as empathy and self-compassion are essential to improve this deficit and overcome the well-known burnout syndrome. mindfulness-based stress reduction (mbsr) program has proven to be an effective intervention for lowering stress in numerous studies. however, this intervention asks for a significant degree of personal involvement, thus the number of dropouts is often reported as a problem. new technologies might allow users to adapt training to their personal schedules. the present randomized trial aims to compare the efficacy of a mindfulness-based training delivered through a mobile application ('rem volver a casa'), a presence-based program (mbsr), and a control group in healthcare grade students.

Eligibility criteria:
inclusion criteria: * student of medicine, nutrition, psychology or nursing. * ability to read and understand spanish language. * signature of informed consent. exclusion criteria: * previous mbsr or anorther standardized mindfulness training. * inability to read or understand spanish language.

Keywords: mindfulness mobile application students anxiety depression self-compassion empathy burnout
lactoferrin use in (sars-cov-2) management

Conditions: Covid19

Summary: background: preventive, adjunctive and curative properties of lactoferrin have been evaluated since the first wave of severe acute respiratory syndrome coronavirus (sars-cov), viral respiratory disease, emerged 18 years ago. despite the discovery of new vaccine candidates, there is currently no widely approved treatment for sars-cov-2 (covid-19). strict adherence to infection prevention and control procedures, as well as vaccines, can, however, prevent the spread of sars-cov-2. objective: hence, this study evaluated the efficacy of lactoferrin treatment in improving clinical symptoms and laboratory indices among individuals with mild to moderate coronavirus disease-19 (covid-19). design and participants: a randomized, prospective, interventional pilot study conducted between july 8 and september 18, 2020 used a hospital-based sample of 54 laboratory confirmed participants with mild to moderate symptoms of covid-19. randomization into a control and two treatment groups ensured all groups received the approved egyptian covid-19 management protocol; only treatment group participants received lactoferrin at different doses for seven days. clinical symptoms and laboratory indices were assessed on days 0, 2 and 7 after starting treatments. mean values with standard deviation and one-way analysis of variance with least significant difference post hoc of demographic and laboratory data between control and treatment groups were calculated. key results: our study showed no stastically significant difference among studied groups regarding recovery of symptoms or laboratory improvement. conclusion: further research into therapeutic properties particularly related to dosage, duration and follow-up after treatment with lactoferrin in individuals with covid-19 is required.


Eligibility criteria:
inclusion criteria: 1. participants over 20 years of age 2. positive for nasopharyngeal swab reverse transcriptase polymerase chain reaction (rt-pcr) for covid-19 3. blood oxygen saturation (spo2) \> 93%. exclusion criteria: 1. pregnant and breastfeeding women 2. individuals confirmed to be allergic to milk protein 3. those with a medical history of bronchial hyperactivity or pre-existing respiratory diseases 4. icu inpatients with covid-19.
a prospective randomized comparison of fentanyl, methadone and morphine for epidural analgesia in an experimental pain model

Conditions: Pain

Summary: the aims of this study are to provide pharmacokinetic-pharmacodynamic data to quantify the analgesic and side effect profiles of epidural methadone, fentanyl and morphine. the investigators will compare the analgesic effect at three dermatomes to assess the rostral spread of drug, the investigators will assess plasma levels to assess the systemic redistribution of drug and the investigators will assess surrogate markers of central opiate effects (nasal capnography and pupilometry). the investigators hypothesize that due to the long-duration of action of methadone, and its intermediate lipophilicity, that methadone will provide a predominantly segmental analgesia of long duration of action, with low rostral spread and low direct central depressant effects (including respiratory depression).


Eligibility criteria:
inclusion criteria: * patients (men and women) scheduled for extracorporeal shock wave lithotrypsy (for nephrolithiasis) under regional anesthesia. exclusion criteria: * inability to understand consent form; poor communication refusal to sign consent form contraindication to regional anesthesia chronic opioid administration asa classification 3 or greater age \ 70

Keywords: epidural analgesia methadone morphine pharmacokinetic-pharmacodynamic experimental pain - analgesic response
titanium surgical mesh and moss-miami screws for lumbar fusion.

Conditions: Degenerative Disc Disease

Summary: the purpose of this study is to determine the clinical success of depuy spine titanium surgical mesh with moss miami spinal fixation system pedicle screws in the treatment of one or two levels of degenerative disc disease of the lumbar spine. the observed success rate at 24 months will be compared to an historical control group treated with the lumbar i/f cage with vsp system.

this is a single arm multi-center study to determine the clinical success of the depuy spine titanium surgical mesh with moss miami spinal fixation system pedicle screws in the treatment of one or two adjacent levels of degenerative disc disease of the lumbar spine (l2 - s1). study success is as a compound endpoint requiring: * radiographic fusion, * improvement in pain/function, * maintenance/improvement in neurologic status, and * freedom from secondary surgical intervention. * the rate of adverse events must be no worse than in the control group as well. secondary endpoints include: * adverse events * sf-36 health related quality of life * disc space height * work status comparison: results will be compared to an historical control group treated with the lumbar i/f cage with vsp system.

Eligibility criteria:
inclusion criteria: * persistent back and/or leg pain refractory to 6 months of non-surgical therapy * radiographic evidence of significant disc degeneration at one or two of the adjacent lumbar levels l2-s1. exclusion criteria: * abnormality at more than two levels, * prior fusion surgery of the lumbar spine; prior discectomies or idet allowed, * infection in the disc or spine, past or present, * active infection at time of surgery, * tumor in the spine, * significant osteoporosis or metabolic bone disease, * greater than grade i spondylolisthesis or significant bony defect in the lumbar spine, * pregnant or lactating, or wishes to become pregnant within duration of study,

Keywords: degenerative disc disease at up to 2 levels (l2-s1)
motivational interviewing to increase prep uptake (mi-prep)

Conditions: Risk Factor

Summary: the purpose of this study is to test a counseling program for black women at high risk for hiv


Eligibility criteria:
inclusion criteria: * hiv-negative * identify as black and/or african american * age 18 or older * cis-gender female * english speaking * is capable of completing and fully understanding the informed consent process and the study procedures and * meets the center for disease control's indications for prep use (17): (a) any sex with opposite sex partners in the past 6 months and (b) not in a monogamous partnership with a recently tested hiv-negative partner or (c) any injection of drugs not prescribed by a clinician in the past 6 months and (d) at least one of the following: (i) infrequently uses condoms in sex with one/more partners of unknown hiv status (ii) in a sexual relationship with an hiv-positive partner or (iii) any sharing of injection/drug preparation equipment in past 6 months. exclusion criteria: * not capable of completing/fully understanding the consent process and the study procedures.

Keywords: hiv prevention prep black african american women motivational interviewing at risk for hiv
accelerated rehabilitation after arthroscopic bankart repair surgery

Conditions: Bankart Lesion

Summary: the aim of this study was to prospectively evaluate the efficacy of an accelerated rehabilitation regime for patients undergoing early arthroscopic stabilization for first-time anterior dislocation in terms of clinical outcome, return to play data and recurrence rates.

traditional rehabilitation regimes post arthroscopic stabilization commonly stipulate a period of immobilization of between 2 weeks and 6 weeks.this is apparently embedded in practice and is reportedly based on tissue healing times. however early mobilisation would allow good clinical results in terms of clinical outcome, return to play data and recurrence rates.

Eligibility criteria:
inclusion criteria: * patient were included based on their history of a clear mechanism of injury resulting in traumatic anterior dislocation, with clear evidence of labral injury confirmed on magnetic resonance imaging. exclusion criteria: * patients with inflammatory, autoimmune, endocrine or kidney diseases * recurrence * bony bankart lesion

Keywords: bankart repair accelerated rehabilitation shoulder
i-scan for adenoma detection

Conditions: Colorectal Adenomatous Polyps

Summary: this study is a randomized controlled trial to determine whether i-scan can improve the detection of conventional adenomas and sessile serrated adenomas/polyps.

this is a randomized controlled trial comparing the use of i-scan (digital surface and contrast enhancement of the mucosa) versus standard high-definition white light for the detection of conventional adenomas and sessile serrated adenomas/polyps. recent studies have indicated that colonoscopy is more effective in preventing cancer in the left side of the colon than the right side of the colon. the reasons for this difference may be partly biologic, in that a special group of polyps known as sessile serrated adenomas/polyps (ssa) are located primarily proximal to the splenic flexure. sessile serrated adenomas/polyps share molecular features with a group of cancers that occur primarily in the proximal colon. these molecular features include cpg island methylator phenotype (cimp) and microsatellite instability. these lesions are endoscopically subtle in that they are often flat, have the same color as the surrounding mucosa, and are hard to differentiate from normal mucosa. recent studies have shown that image enhanced endoscopy can highlight the appearance of these lesions. this study will test whether i-scan increases the detection of conventional adenomas and sessile serrated adenomas/polyps in a randomized controlled trial.

Eligibility criteria:
inclusion criteria: * age 50-75 * intact colon and rectum * willing to sign an informed consent form exclusion criteria: * subjects less than 50 years of age or greater than 75 years of age * subjects who are in the inpatient unit * subjects with diverticulitis, * subjects with inflammatory bowel disease * subjects with polyposis syndromes * subjects with previous surgical resection of any portion of the colon or rectum * subjects referred for endoscopic resection of previously diagnosed colorectal polyp
efficacy study of mirtazapine to treat interferon-related depression during antiviral therapy for hepatitis c

Conditions: Depression

Summary: the purpose of this study is to evaluate the anti-depressive efficacy of mirtazapine in depression induced by peginterferon alpha-2a and ribavirin treatment in korean patients with chronic hepatitis c.

depression is a common serious adverse event (30%-50%) during the interferon treatment for chronic hepatitis c. adequate control of depressive symptoms might enable to adhere to antiviral therapy and lead to the favorable prognosis for patients with chronic hepatitis c. mirtazapine is an effective antidepressant for depressive mood as well as insomnia and anxiety. mirtazapine has also relatively lower drug-drug interactions, which are important for patients with hepatic dysfunction. in this study, the investigators are going to perform an 8-week, randomized, open label trial comparing anti-depressive efficacy between mirtazapine and supportive psychotherapy in depression induced by peginterferon alpha-2a and ribavirin treatment in korean patients with chronic hepatitis c.

Eligibility criteria:
inclusion criteria: * major depressive episode diagnosed with diagnostic and statistical manual diploma in social medicine-iv (dsm-iv) * hamilton depression scale (hamd-17) ≥ 14 exclusion criteria: * any other axis i primary diagnoses except major depressive disorder * having serious adverse events or hypersensitivity to mirtazapine * having major depressive disorder prior to the first injection of interferon

Keywords: depression interferon chronic hepatitis c mirtazapine
phase ii dose finding study of rdea3170 versus placebo in japanese patients with gout or asymptomatic hyperuricemia

Conditions: Gout and Hyperuricemia

Summary: this study is to examine the hypothesis that administration of rdea3170 to japanese patients with gout or asymptomatic hyperuricemia in doses of 5 mg, 7.5 mg, 10 mg, 12.5 mg and 15 mg once daily, respectively will result in greater reduction of sua compared to placebo.


Eligibility criteria:
inclusion criteria: * subject meets any of the following criteria and with sua ≤10.0 mg/dl: 1. sua level of \>7.0 mg/dl at 7 days prior to baseline with gout; 2. sua level of ≥8.0 mg/dl at 7 days prior to baseline without gout but with complications (hypertension, ischemic heart disease, diabetes, metabolic syndrome); 3. sua level of ≥9.0 mg/dl at 7 days prior to baseline without gout and complications. exclusion criteria: * subject with an acute gout flare that has not resolved at least 14 days prior to the baseline visit. * subject has a history or suspicion of kidney stones. * subject has an estimated creatinine clearance \<60 ml/min calculated by the cockcroft gault formula * subject is receiving strong or moderate cyp3a inhibitors
compare outcomes of cpr between the video-laryngoscopy (vl) users and the direct-laryngoscopy (dl) users

Conditions: Cardiopulmonary Arrest

Summary: this is a clinical study based on the analysis of video-clip data of cardiopulmonary resuscitation (cpr) and clinical data for out of hospital cardiac arrest patients between 2011 and 2015. aim of study is to compare the endotracheal intubation performance and cpr outcomes between videolaryngoscopy (vl) and direct laryngoscopy (dl) users.

endotracheal intubation (eti) has been considered to be the best method of airway management during cardiopulmonary resuscitation (cpr). however eti during cpr is a highly skill-dependent procedure, then it should be attempted only highly trained physicians. because of technical difficulty in using direct laryngoscopy (dl), various types of videolaryngoscopy (vl) devices using micro-camera technology have been designed to overcome the problems of dl. this study tried to compare the recovery of spontaneous circulation (rosc) and survival discharge between use of standard device (dl) and vl in a real clinical setting. in addition, this study also compare the first pass success rate of eti,speed of eti, incidences of complications, and chest compression interruptions during cardiopulmonary resuscitation between both device users.

Eligibility criteria:
inclusion criteria: * patients who suffer sudden out-of hospital cardiac arrest exclusion criteria: * cardiac arrests from multiple trauma * cases of requesting the do-not attempt resuscitation before eti * intubated cases before arrival to emergency department

Keywords: intubation cardiopulmonary resuscitation
seizure recurrence after unprovoked first seizure

Conditions: Single Seizure; Epilepsy

Summary: one in 10 people have a seizure during their life. usually no cause is identified. seizures without an identified cause are called unprovoked first seizure (ufs). most people with ufs do not have further seizures. being able to predict the risk of more seizures as soon as possible would help doctors decide whether to suggest treatment after ufs. studies show that seizures are associated with changes in brain structure and function that are difficult to detect with standard assessments but can be detected with advanced techniques. changes in connections between brain regions are also linked to subtle problems in thinking and mood. the investigators will examine brain connections using detailed brain scans, thinking, and mood in people with ufs and develop an accurate method for calculating the risk of further seizures. 200 adult patients and 75 matched healthy controls from the halifax and kingston first seizure clinics will undergo cognitive screening assessment of major cognitive domains, mri imaging including structural scans, resting-state functional mri (rsfmri) and diffusion-weighted imaging (dwi), and eeg. seizure recurrence will be assessed prospectively and a multimodal machine learning model will be trained to predict seizure recurrence at 12 months.


Eligibility criteria:
inclusion criteria: * this study will consider adult patients between the ages of 18-65 years seen in the first seizure clinics in halifax and kingston with unprovoked first seizure. * the investigators will also include a sample of age, sex, and education-matched healthy controls with the same exclusion criteria. exclusion criteria: * individuals over the age of 65 will not be included to reduce the probability of including individuals with early dementia. * the investigators will also exclude individuals who, upon assessment during their first clinic appointment, are determined to have non-epileptic events, recurrent events or diagnosis of epilepsy (e.g. based on abnormal ct or eeg), provoked seizure (e.g. medication, substance misuse, metabolic), acute symptomatic seizures, those with an existing prescription for antiseizure drugs, significant cns comorbidity that may affect cognition and brain networks (e.g. progressive neurological disorder, ms), previous neurosurgery, or contraindication to mri. * finally, although there is no known risk to a fetus from mri scanning, as is standard in research studies involving mri, pregnant participants will be excluded and those that suspect that they may be pregnant require a negative pregnancy test before scanning.

Keywords: cognition mood brain connectivity neuroimaging neurophysiology
a study of lu ag06466 for the treatment of spasticity in participants with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: the main purpose of this study is to investigate lu ag06466 as a treatment for spasticity in participants with multiple sclerosis (ms).

the participants will be randomized to lu ag06466 or placebo in a 2:1 ratio.

Eligibility criteria:
key inclusion criteria: * the participant has a diagnosis of ms, as per the 2017 mcdonald criteria. * the participant has clinically stable ms (such as no relapse and/or stable expanded disability status scale \[edss\] or alternative clinical assessment score) for at least 6 months prior to screening. * the participant has ongoing spasticity for at least 90 days prior to screening. * the participant is on a stable regimen for at least 30 days prior to screening for all medications and non pharmacological therapies, including therapies that are intended to alleviate spasticity (for example, oral baclofen, tizanidine, dalfampridine), and willing to remain on the same regimen throughout the duration of the study. * the participant reports walking impairment due to lower limb spasticity. key exclusion criteria: * the participant has any concomitant disease or disorder that has spasticity-like symptoms or that may influence the participant's level of spasticity or the participant's overall ability to participate in the study. * the participant has ambulation difficulties due to any concomitant disease or disorder other than ms. * the participant has any known or suspected hypersensitivity to cannabinoids (cbs) or any of the excipients of the investigational medicinal product (imp). * the participant has a positive drug screening test, except for non-cb medications used to treat a medical condition and reported as such by the participant; the participant has a positive drug screen test for cannabis/delta-9-tetrahydrocannabinol. other inclusion and exclusion criteria may apply.