Kornimate/medical-research-clean huggingface dataset:
nac supplementation and soccer specific performance

Conditions: Skeletal Muscle Damage; Exercise-induced Aseptic Inflammation; Skeletal Muscle Performance; Antioxidant Status

Summary: in this investigation the investigators utilized nac supplementation to boost gsh availability during an one-week-microcycle consisting of three soccer games, in order to test the hypotheses that: i) antioxidant supplementation may enhance the recovery of performance and physiological stress variables following multiple match-plays and ii) redox status perturbations are critical in regulating the inflammatory response and repair in skeletal muscle, following repetitive exercise-induced muscle injuries.

after exercise-induced muscle microtrauma the thiol/disulfide couple of reduced (gsh) and oxidized glutathione (gssg) is a key regulator of important transcriptional pathways that control the inflammatory response and recovery of skeletal muscle. the objective was to examine how thiol-based antioxidant supplementation affects the muscle damage, oxidative stress, inflammatory and immune responses, as well as the level of post-game fatigue and muscle's recovery kinetics in response to three soccer games within a week. participants were randomly assigned to one of four groups: i) experimental-nac \[exp-nac, n=10, participated in daily training sessions and three games and received nac (20 mg/kg/day)\], ii) experimental-placebo (exp-pla, n=10, participated in daily training sessions and three games and received placebo), iii) control-nac \[con-nac, n=10, participated in daily training sessions only and received nac(20 mg/kg/day)\] and iv) control-placebo (con-pla, n=10, participated in daily training sessions only and received placebo). blood samples were collected at baseline, post-games and daily during recovery. performance was assessed at baseline and daily during recovery.

Eligibility criteria:
inclusion criteria: * participation at elite level (top three division leagues) of soccer competition for at least five years * abstained from consumption of performance-enhancing supplements, antioxidant supplements and medications (for at least 6 months before and during the study) * participation in at least six two-hour training sessions and one match per week * non-smokers exclusion criteria: * a known nac intolerance or allergy * a recent febrile illness * history of muscle lesion * lower limb trauma * metabolic diseases
stress cardiac mri in ischemic patients

Conditions: Ischemic Cardiomyopathy

Summary: the aim of this study is to assess the diagnostic accuracy of cmr feature-tracking (ft) at rest \& during stress with low dose dobutamine (ldd) in the evaluation of viability in ischemic cardiomyopathy (icm) patients and compare it with delayed gadolinium enhancement (dge).


Eligibility criteria:
inclusion criteria: * all patients recruited into the study have chronic lv systolic dysfunction due to coronary artery disease (cad) exclusion criteria: * all patients with a contraindication to mr study: * patients with implanted non-mri compatible electronic devices (e.g. cardiac pacemakers, intracranial metallic clips, implanted hearing aids, etc.) * patients with foreign bodies in the eye. * claustrophobic patients. * patients diagnosed with recent acute coronary syndrome within 4 weeks. * patients who had contraindications for mri or contrast agents, and those with poor image quality due to either inadequate breath holding or arrhythmias
metabolic syndrome and functional food

Conditions: Metabolic Syndrome

Summary: high blood sugar and adiposity are part of metabolic syndrome (about 24% of adults harbor it). the main approach, weight reduction, is often unattainable. aloe vera (barbadensis) (av) and cnidoscolus chayamansa (mcvaugh)(cc) are two vegetables that seem to have an effect on blood glucose and body weight. the study aims to determine if the intake of aloe gel and/or chaya infusion can reduce high blood sugar in adult women with pre-diabetes (metabolic syndrome). methods: a factorial assay, double blind, cross-over-controlled with random assignment, to four treatments: av and cc, av and placebo 1, placebo 2 and cc, and placebo 1 and placebo 2, at the outpatient clinic of the university hospital and a community clinic. two treatment periods of 4 weeks intermediated by one week for wash-out.


Eligibility criteria:
inclusion criteria: * adult women living in monterrey, mexico with at least three of the following: * waist line equal or larger than 88 cm * fasting blood sugar between 100-140 mg/dl without symptoms or known glucose intolerance or diabetes treated only with diet * known high blood pressure or 2/3 readings systolic \> 130 mmhg, diastolic \> 85 * hld \ 150 mg/dl exclusion criteria: * pregnancy or nursing * on anti-diabetic agents * diabetic symptoms or advanced dm complications * severe behavioral problems

Keywords: hyperglycemia overweight functional food aloe vera cnidoscolus chayamansa
stepup clinical trial

Conditions: Peripheral Artery Disease

Summary: this study will test whether, among patients undergoing surgery for peripheral artery disease (pad), the addition of an online multimedia patient education video to the current education regimen will improve pad knowledge, activation, and self-care engagement. the study will randomize 150 participants to one of 2 groups: current education regimen vs. current education regiment with video. the primary outcome is stage of self-care engagement. secondary outcomes are pad knowledge, self-efficacy, and activation. a subset of participants will also be randomly selected to participate in semi-structured interviews. study duration for participants is 6 months.


Eligibility criteria:
inclusion criteria: * patient undergoing surgery for pad in division of vascular surgery at northwestern memorial hospital exclusion criteria: * inability to provide informed consent * inability to complete study protocol * previously viewed the pad education video * participation in pilot study
study of new imaging criteria for the diagnosis of caroli's disease

Conditions: Caroli Disease; Magnetic Resonance Imaging; Cholangiopancreatography

Summary: the caroli disease is a very rare pathology that can be revealed early in childhood or in adulthood, whose diagnosis is based on magnetic resonance cholangiopancreatography, which shows the communication of these malformations with the rest of the biliary tree and allows to eliminate biliary stenosis. the radiologist has a central role in the diagnostic orientation between malformative intra-hepatic bile duct dilatation and obstructive benign or malignant intra-hepatic bile duct dilatation dilatation. however, imaging of caroli disease is polymorphous and therefore subject to misinterpretation. the benefit of this research is to reduce diagnostic errors by highlighting imaging criteria specific to the caroli disease

the magnetic resonance cholangiopancreatography will have been performed in all patients using different magnetic resonance imaging systems (gyroscan intera, philips medical systems, best in the netherlands, magnetom avanto, siemens medical solutions, and signa hdxt, general electric medical systems) with a free-breathing three-dimensional high-spatial-resolution fast spin echo sequence and/or a breath-hold two-dimensional single-shot sequence. magnetic resonance cholangiopancreatography may also include a fast spin echo weighted t2-weighted sequence with fat-spectral saturation, a t1-weighted breath-suppressed gradient echo pulse sequence and a chemical shift sequence in phase and opposite phase, in the axial plane, and a weighted three-dimensional t1 saturated fat sequence after intravenous administration of gadolinium chelate. images will be analyzed in consensus by two abdominal radiologists on a picture archiving and communication system station and compared with the pathological results.

Eligibility criteria:
inclusion criteria: * were patients identified in the database of the hospitals who underwent * a diagnosis of caroli disease on an imaging report with bile duct dilatation limited to the intrahepatic biliary tree and * an available magnetic resonance cholangiopancreatography on a picture archiving and communication system. exclusion criteria: * obstructive benign or malignant proximal biliary stricture on magnetic resonance cholangiopancreatography * prior surgical interventions for hepatobiliary disease except cholecystectomy
parathyroid hormone kinetics during crrt

Conditions: Critical Illness; Multi Organ Failure; Renal Failure; Circulatory Failure; Respiratory Failure

Summary: the objective of this study is to assess the parathyroid hormone serum concentrations and kinetics in critically ill patients admitted to the intensive care unit due to multi-organ failure and undergoing citrate anticoagulation continuous renal replacement therapy.


Eligibility criteria:
inclusion criteria: * acute respiratory failure * acute circulatory failure * acute kidney injury treated with regional citrate anticoagulation continuous renal replacement therapy by means of continuous veno-venous hemodiafiltration (cvvhdf * continuous renal replacement therapy started no later than 48 hours after admission * sofa score 5 or more exclusion criteria: * age less than 18 years * acute liver failure * hypercalcemia at admission (total calcium plasma level \> 10.6 mg/dl; total ionized calcium plasma level \> 1.35 mmol/l * parathyroid glands disease * end stage renal disease * therapeutic plasma exchange * extracorporeal membrane oxygenation * unfavorable outcome (death) predicted within 72 hours (as assessed by investigator) * lack of relatives consent

Keywords: acute kidney injury parathyroid hormone continuous renal replacement therapy citrate anticoagulation intensive care
development and validation of perceived fatigue meaning scale on walking program

Conditions: Gastric Cancer

Summary: the aims of this three-year study are to: 1. develop and validate a perceived meaning of fatigue scale 2. examine the effect of individualized patient education and walking programs on alleviating fatigue in patients with gastric or colorectal cancer,and further explore the relationship between the perceived meaning of fatigue and intervention outcome.

in the first year, patients will be recruited from oncology inpatient wards and outpatient clinics in two medical center hospitals in taipei. purposive sampling will be used to recruit outpatients or inpatients receiving chemotherapy. data will be analyzed by descriptive analysis, independent t-test, pearson correlation, one-way analysis of variance, and exploratory factor analysis. in the second and third years, an experimental design consisting of three groups including a control group, an education only group, and an education and walking program group will be used. data will be collected at treatment weeks 1, 4,8,12,16 including three cycles of chemotherapy. data will be analyzed by descriptive analysis, independent t-test, pearson correlation, and generalized estimating equations. at least 230 subjects will be interviewed in the first year. at least 105 of patients with gastric cancer or colorectal will be classified into the three groups in the second and third year. we expect the results of this study to explore the meaning of fatigue and to help develop a common strategy to manage fatigue in taiwan. the results can help clinicians and researchers to tailor interventions for cancer patients with severe fatigue.

Eligibility criteria:
inclusion criteria: * the patients with gastric cancer during receiving chemotherapy * those who are willing to participate in the research * aged above 18

Keywords: fatigue meaning education walking program
study of the safety and biologic activity of xoma 052 in subjects with type 2 diabetes mellitus

Conditions: Type 2 Diabetes Mellitus

Summary: the study hypothesis is that xoma 052 is likely to improve glycemic control in subjects with type 2 diabetes mellitus. the purpose of this study is to determine whether xoma 052 improves glycemic control in subjects on metformin monotherapy whose diabetes is still not adequately controlled.


Eligibility criteria:
inclusion criteria: * diagnosed with t2d (disease duration \>= 6 months) * hba1c measurements \>= 7.0% and \<= 10.0% * on a stable regimen of metformin monotherapy * age \>= 18 and \<= 75 * stable diet and exercise regimen * bmi \<= 40 kg/m2 exclusion criteria: * significant signs and symptoms of uncontrolled hyperglycemia (i.e., polyuria, polydipsia, or polyphagia) * uncontrolled hypertension (systolic \> 170 mmhg and/or diastolic \> 110 mmhg) * known to be positive for hep b surface antigen (hbsag), hep c virus (hcv), or hiv * history of allergic or anaphylactic reactions to humanized or murine monoclonal antibodies * advanced stage heart failure (new york heart association \[nyha\] class 3 or 4) * pulmonary disease requiring medication other than inhaled corticosteroid s * history of tuberculosis or positive ppd test. * active leg, foot, or decubitus ulcer * any significant inflammatory, rheumatologic, or systemic autoimmune disease * history or any symptoms of a demyelinating disease * history of severe non-proliferative or proliferative retinopathy other protocol-defined inclusion/exclusion criteria may apply

Keywords: diabetes type 2 mellitus
laparoscopic splenic flexure mobilization

Conditions: Splenic Flexure Mobilization

Summary: this retrospective cohort study conducted on 140 patients who underwent laparoscopic anterior resection for upper rectal cancer in the period from may 2011 to november 2015, comparison will be done on splenic flexure mobilization excluding .

presently, it is acknowledged that laparoscopic colectomy for left sided colorectal cancer is the most common surgery operated in laparoscopic colorectal surgeries, however the most debatable question in such type of operations that is it mandatory to do splenic flexure mobilization or not? in the literatures colorectal surgeons divided into 2 teams, those with splenic flexure mobilization in laparoscopic left colorectal resection to have tension free, well vascularized anastomosis on the other hand those against splenic flexure mobilization reported that omitting this step does not significantly affect the leakage rate, morbidity or the oncological outcomes in this study, we evaluate the necessity of splenic flexure mobilization in laparoscopic anterior resection for upper rectal tumors and its impact on the operative time, total morbidity, leakage rate, oncological safety and continence level

Eligibility criteria:
inclusion criteria: * patients with upper rectal tumors. exclusion criteria: * low and mid rectal cancer * splenic flexure tumors, descending colon cancer, * patients with associated lesions in the right or transverse colon * emergency cases.

Keywords: laparoscopic colectomy. splenic flexure mobilization. anastomotic leakage.
baerveldt (bgi) valve versus ahmed(agv) valve in management of difficult glaucoma cases

Conditions: Glaucoma, Open-Angle; Glaucoma Secondary; Glaucoma, Neovascular; Glaucoma, Angle-Closure

Summary: refractory glaucoma is a difficult subject as many glaucoma devices attempt to reduce iop. baerveldt implant is considered as a large implant, and, on the contrary, ahmed implant is considered a small implant as many comparisons have showed. investigators have previously used two models s2 and fp7 ahmed implant. currently, investigators use baerveldt implant in refractory glaucoma cases in order to compare it with the ahmed implant.

eighty-one participants with glaucoma after ocular surgery or secondary glaucoma with persistent and uncontrolled iop \> 21 mmhg were randomized for placement of baerveldt implant or ahmed implant models using a standardized surgical technique. the primary outcome was failure, which was defined as iop \>16 mmhg with glaucoma medication on 2 consecutive study visits. secondary outcomes were iop, medication use, visual acuity, complications, and interventions.

Eligibility criteria:
inclusion criteria: 1 - patients with glaucoma who underwent a previous failed trabeculectomy or other intraocular surgery. 2- patients who had secondary glaucoma and are known to have a high failure rate with trabeculectomy such as neovascular, uveitis, or iridocorneal endothelial syndrome-associated glaucoma, were included in the study. exclusion criteria: 1 - patients lacked light perception, unwilling or unable to give informed consent, were expected to be unavailable for follow-up visits. 2-had previous aqueous shunt implanted in the same eye, other external impediment to supero-temporal drainage device implantation. 3- presence of silicone oil, vitreous in the anterior chamber sufficient to require a vitrectomy. 4-uveitis associated with a systemic condition like juvenile rheumatoid arthritis, nanophthalmos, sturge-weber syndrome or other conditions associated with elevated episcleral venous pressure.
the value of preoperative dynamic lymphscintigraphy and ultrasoundscanning, eventually with fna, for identification of malignant sentinel node(s) in patients with melanoma

Conditions: Melanoma

Summary: the goal with this study is to evaluate the value of dynamic lymphscintigraphy and ultrasoundscanning preoperative in patients with melanomas.


Eligibility criteria:
inclusion criteria: histologically verified melanomas, at least 1 mm thickness, or thinner melanomas with ulceration and/or clarks level iv-v and/or mitoserate at least 1/mm2. exclusion criteria: other malignant illness known local, regional or non-regional metastasis on the time of diagnonsis comorbidity which contraindicate lymphnoderemoval age less than 18 yrs
the effect of coffee and hot water on gastroıntestınal functıons

Conditions: COFFEE; Gastrointestinal Motility and Defecation Conditions

Summary: the aim of this study is to examine the effects of coffee and hot water consumption on gastrointestinal system functions after cesarean section performed under general anesthesia. the study is in a randomized controlled experimental design. the sample of the study consisted of 25 participants in the coffee group (group 1), 26 participants in the hot water group (group 2) and 27 participants in the control group (group 3). after cesarean section, at the 4th, 8th and 12th hours of the operation, the first intervention group (coffee group) received 2 gr. granulated coffee, the second intervention group (hot water group) was given 100 ml of 50-60 c0 sugar-free hot water, the third group (control group) was given no intervention other than routine applications.

objective: the aim of this study is to examine the effects of coffee and hot water consumption on gastrointestinal system functions after cesarean section performed under general anesthesia. materials and methods: the study is in a randomized controlled experimental design. patients who had an uncomplicated cesarean section under general anesthesia, were older than 18 years of age, completed the 37th week of pregnancy, did not have any gastrointestinal system disease that could affect the results of the study, and did not use drugs, and who could understand and speak turkish were included in the study. the sample of the study consisted of 25 participants in the coffee group (group 1), 26 participants in the hot water group (group 2) and 27 participants in the control group (group 3). after cesarean section, at the 4th, 8th and 12th hours of the operation, the first intervention group (coffee group) received 2 gr. granulated coffee, the second intervention group (hot water group) was given 100 ml of 50-60 c0 sugar-free hot water, the third group (control group) was given no intervention other than routine applications.

Eligibility criteria:
inclusion criteria: * cesarean section performed by the physician determined in the research * over 18 years old, * completing the 37. gestational week, * do not have any gastrointestinal system disease that may affect the results of the research and do not use drugs, * able to understand and speak turkish, * women who voluntarily participated in the study exclusion criteria: * cesarean section performed by a different physician than the physician determined in the study. * younger than 18, * not completing the 37.gestational week * having any gastrointestinal system disease that may affect the research results and using medication * can't understand or speak turkish.

Keywords: cesarean section coffee bowel sound flatulence
therapeutic omegas for triglyceride suppression

Conditions: Pregnancy

Summary: this study plans to learn more about how an omega-3 fatty acid supplement effects triglyceride levels in pregnancy. triglycerides are a type of fat found in your blood. your body converts extra calories into triglycerides to be stored and used later for energy. it is normal for triglyceride levels to go up during pregnancy however some women have levels that are \~30-40% higher than normal when they reach their third trimester of pregnancy. having high triglycerides in pregnancy may be related to an increased chance of having a baby that is large for their age. the goal of this study is to determine if taking an omega-3 fatty acid supplement can slow the rise in triglyceride levels later in pregnancy.


Eligibility criteria:
inclusion criteria: * pregnant women between the ages of 21-39 yrs * pre-pregnancy bmi 28-39 * fasting triglyceride ≥120 mg/dl measured by 15 wks exclusion criteria: * pre-gestational diabetes or prediabetes * history of gestational diabetes, * history of pre-eclampsia, spontaneous pre-term delivery, or gestational hypertension \<34wks * tobacco or illicit substance use * chronic steroid use

Keywords: triglycerides glucose adiposity air displacement plethysmography continuous glucose monitoring