Kornimate/medical-research-clean huggingface dataset:
narrowband uvb phototherapy in the treatment of psoriasis vulgaris

Conditions: Chronic Plaque Psoriasis

Summary: ultra-violet light b (uvb) therapy has been used by dermatologists to treat psoriasis for decades. only a few studies have begun to dissect the mechanism of how nb-uvb therapy causes lesion resolution. results from this study will aid in identifying other diseases that may be treated successfully with nb-uvb. if we can identify the mechanism of action of this therapy, this may give us additional new therapeutic targets for psoriasis and other diseases. our overall hypothesis is that uvb induces changes that will indicate a mechanism of action of this therapy in psoriasis.


Eligibility criteria:
inclusion criteria: * signed informed consent. * history of chronic plaque psoriasis vulgaris, for at least six months. * ≥10% body surface affected * age 18 or greater. * concomitant, chronic, but well-controlled medical conditions such as hypertension are allowable. * no treatment with topical steroids for at least 2 weeks prior to entering the study * no treatment with systemic therapies, including etretinate, uvb, puva, or cyclosporine, other biologics 4 weeks prior to entering the study. however, if a patient is considered to be "unstable", or would deteriorate clinically if the systemic agent is ceased (eg efalizumab), a shorter "washout" period may be considered, and would be documented in the patient charts. * patients who receive a stable dose of methotrexate (defined as \<15mg/week for 4 months or greater) for psoriatic arthritis may be included. exclusion criteria: * subjects who do not meet the above criteria, or who meet any of the following criteria: * guttate, erythrodermic, or pustular psoriasis as sole or predominant form of psoriasis. * photosensitivity: hypersensitivity to sunlight or uvb light of any type; history of lupus, pmle, or any disease known to be worsened by uv light exposure * a history of non-melanoma skin cancer may be acceptable, and in this situation, the patient will be carefully evaluated. * poorly controlled medical conditions of any kind. * any medical condition that, in the opinion of the investigator, would jeopardize the health or well being of the patient during the course of this study.
pioneer study of lifestyle intervention to reduced breast cancer risk

Conditions: Breast Cancer; Lifestyle Risk Reduction

Summary: a randomised controlled trial in which women discharged from the symptomatic breast clinic, who are above population risk (according to tyrer cuzick) will be asked to create lifestyle related goals. they will be told their estimated risk of developing breast cancer and will be randomised to one of three interventions: * breast cancer risk leaflet only * lifestyle website * lifestyle website plus group coaching. fifty per cent of women will also be randomised to have single nucleotide polymorphisms (snps) performed, and these will be incorporated into their risk score. the primary end point will be whether or not women achieve their lifestyle goal.


Eligibility criteria:
inclusion criteria: * female * aged between 30 and 60 years * attending the symptomatic breast clinic at rmh sutton or chelsea or the family history clinics at rmh sutton or chelsea, or has heard about the study through other means such as (but not limited to), friends who have been diagnosed with cancer, friends who are already taking part in the pioneer study, social media, mainstream media, fliers through the doors of houses in the area of rmh. * benign or b3 diagnosis if participant has attended clinic * agree to receive their personalised breast cancer risk * available to participate in a 1 year risk prevention programme * able to attend the royal marsden for a blood test if randomised to this group exclusion criteria: * malignant diagnosis * does not want to find out personalised breast cancer risk * not available to participate for the full year * note: after risk assessment, women who have a breast cancer risk lower than that of population level will be excluded from participating in the behavioural change elements.
histomorphometry analysis in fertile and infertile patients

Conditions: Infertility

Summary: to detect similarities and differences in the endometrium of fertile and infertile patients

morphometric and pathologyc analysis of the endometrium in fertile and infertile patients

Eligibility criteria:
inclusion criteria: * 18 to 41 years old * regular menses * infertility over 12 months exclusion criteria: * previous uterine surgery * use of contraceptive pills or injections less than 3 months from the inclusion in the study

Keywords: endometrium infertility uterus histeroscopy
the effects of continuous intake of ons on the nutritional status of taiwanese elderly

Conditions: Malnutrition Elderly

Summary: past studies have pointed out that adequate intake of calories and protein in the elderly can deferred sarcopenia and debilitating conditions. therefore, this study intends to use oral nutrition as a way of nutritional supplements, without affecting the subjects' normal meal intake, and supplements with snacks it is expected that there will be benefits in protein and muscle synthesis. however, the palatability of oral nutritional products will affect the effectiveness of nutritional supplements. therefore, this test provides nutrients that are easy for the subjects to ingest with a variety of flavors, in order to achieve the test calories and protein needs. in order to investigate and compare the nutritional status, serum zinc and vitamin d status in healthy (must score 0) elderly and at risk of malnutrition elderly, we recruited healthy elderlies in the nursing home.

in this study, subjects were randomly assigned. through a multi-center research method, a total of 100 eligible subjects were recruited, and their consent was obtained and a subject consent form was signed. the subjects were divided into two groups according to the way of nutritional intervention, including nutritional education (ne) and nutritional supplement drink (nsd), with 50 people in each group. the ne group is given regular nutrition education by qualified clinical nutritionists to ensure the effectiveness of nutrition education. in the nsd group, in addition to nutrition and health education, daily oral supplements (meiji mei balance, meiji co., ltd., tokyo, japan) are provided daily, and snacks are supplemented between lunch and dinner and before bedtime, 2 per day. bottle. the two groups were divided into groups by lottery, and the intervention period was 12 weeks. during the intervention period, blood will be drawn at the beginning, 6th, and 12th week of the case, and blood pressure, body position, body composition and muscle strength will be measured, and dietary intake will be assessed. at the same time, a quality of life survey will also be conducted. survey, qol survey. moreover, we recruited 50 healthy elderly to investigate and compare the nutritional status, serum zinc and vitamin d status in healthy elderly and at risk of malnutrition elderly. this group was considered as a control group and we didn't do any intervention after blood collection and physical measurements.

Eligibility criteria:
inclusion criteria: 1. age \>65 years old (regardless of gender) 2. malnutrition risk judgment: subjects were assessed as moderate and high malnutrition risk with the malnutrition risk screening tool must (malnutrition universal screening tool) exclusion criteria: 1. chronic diseases such as diabetes, end stage of chronic kidney disease, cancer.

Keywords: sarcopenia, oral nutritional supplement, elderly people, nutritional education, malnutrition risk
a study of tagraxofusp in combination with venetoclax and azacitidine in adults with untreated cd123+ acute myeloid leukemia who cannot undergo intensive chemotherapy

Conditions: Acute Myeloid Leukemia

Summary: this study will be divided into 2 parts (part 1 and part 2). part 1 will evaluate 2 doses of tagraxofusp (9 and 12 micrograms/kilogram/day \[μg/kg/day\]), used in combination with venetoclax and azacitidine, to determine the dose for part 2. this determined dose, in combination with venetoclax and azacitidine, will then be further evaluated in part 2 in 2 cohorts (tp53 mutated and tp53 wild type). both parts will be conducted in participants with previously untreated cd123+ aml who are ineligible for intensive chemotherapy.


Eligibility criteria:
key inclusion criteria: * previously untreated with histological confirmation of aml by world health organization 2022 criteria and are ineligible for treatment with a standard cytarabine and anthracycline induction regimen due to age, or comorbidity. * participant has any level of cd123 expression on blasts confirmed centrally by flow cytometry. * must be considered ineligible for intensive chemotherapy, defined by the following: * ≥75 years of age; or * ≥18 to 74 years of age with at least 1 of the following comorbidities: * eastern cooperative oncology group (ecog) performance status of 2 or 3. * diffusing capacity of the lung for carbon monoxide of ≤65% or forced expiratory volume in 1 second ≤65%. * baseline creatinine clearance ≥30 to \<45 milliliters/minute calculated by the cockcroft gault formula or measured by 24-hour urine collection. * hepatic disorder with total bilirubin \>1.5 x upper limit of normal. * any other comorbidity that the investigator judges to be incompatible with intensive chemotherapy must be reviewed and approved by the sponsor. * ecog performance status: * 0 to 2 for participants ≥75 years of age, or * 0 to 3 for participants ≥18 to 74 years of age. key exclusion criteria: * participant has received prior therapy for aml. * willing and able to receive standard induction therapy. * treatment for an antecedent hematologic disease with a hypomethylating agent, venetoclax, tagraxofusp, purine analogue, cytarabine, intensive chemotherapy, chimeric antigen receptor-t therapy, or other experimental therapies. * aml with central nervous system involvement. note: other inclusion/exclusion criteria may apply.

Keywords: cd123+ tagraxofusp venetoclax azacitidine
evaluation of the elasticity of the mitral valve

Conditions: Mitral Valve Disease

Summary: there is no information in the literature on the mechanobiological characteristics of mitral valve chords in living humans. all examinations were carried out on tissues taken from animals, either from cadavers or from frozen human tissues. the objective is to determine mechanobiological and histological characteristics of the mitral valve chords in living humans, as well as to compare differences in elasticity in different groups (group a: patients with mitral valve prolapse versus group b: patients with restrictive ischemic mitral valve).

the prospective study will be conducted on 20 patients, who will be selected consecutively without randomization. the inclusion and exclusion criteria are determined. the harvested tissue will not be frozen and will kept in natural conditions as close as possible.

Eligibility criteria:
inclusion criteria: all patients programmed for mitral valve replacement who have more than 45 years old exclusion criteria: * patients with mitral calcification * mitral valve rheumatic disease * mitral valve infections * redo surgery on the mitral valve

Keywords: mitral valve mitral valve chords elasticity young's modulus mitral valve histology
a stepped care model to deliver cbt-i in community

Conditions: Insomnia; Sleep Disturbance

Summary: insomnia is one of the most common sleep disorders and affects approximately 10 - 40% of the population across different age groups in hong kong. cognitive behavioral therapy for insomnia (cbt-i) is the first line treatment for adult insomnia due to its comparable effect to medication in short term but is more sustainable in the long run. however, only a few sufferers have received cbt-i, due to limited accessibility, lack of trained sleep therapists, time costing and geographical limitations. to increase cbt-i accessibility, different formats of cbt-i have been proposed. empirical evidence including ours consistently suggested that self-help digital cbt-i is effective in improving sleep while its augmentation with a guided approach could further enhance the treatment gain. previous evidence has suggested that although self-help cbt-i could lead to positive outcomes, the drop out rate is quite high and maybe less effective for patients with comorbidity or high level of distress. thus, a stepped-care approach to cbt-i that utilizes online self help and therapist-guided modes of delivery might be a potential way to facilitate efficient dissemination of effective insomnia treatment resources. the effectiveness of the stepped care model will be evaluated in a real world setting using stepped-wedge cluster randomized controlled design. the program will be rolled out to different districts in hong kong sequentially in 18 districts over 4 steps with a eqaully spaced time periods.

this interventional study will be a multicenter, assessor-blinded, pragmatic stepped-wedge cluster randomized controlled trial. a total of 18 districts will be included in the study and the randomization will be carried out based on the districts. the stepped-care cbt-i intervention will be sequentially rolled out to the 4-6 districts per step according to a computer-generated random number while the remaining clusters will continue to stay unexposed to the cbt-i intervention over the control period. therefore after 4-step exposure, all clusters will receive the stepped-care cbt-i intervention. a total of 3 follow-up assessments (post intervention, 3-month and 12-month follow up) will be conducted to assess the effectiveness and long-term effects of the stepped care model.

Eligibility criteria:
inclusion criteria: 1. chinese adults aged 18-70 years old, 2. the score of insomnia severity index ≥ 10. exclusion criteria: 1. present with psychotic disorders such as bipolar disorder and schizophrenia, 2. present with severe depression or suicidal ideation, 3. present with neurodegenerative diseases that prevent participant from completing the intervention (e.g., dementia and parkinson's disease). 4. unable to provide consent

Keywords: insomnia stepped care model stepped wedge cluster randomized trial
single versus multiple visits endodontic treatment

Conditions: Periapical Periodontitis

Summary: healing rate after single visit or multiple visit endodontic treatment using triple paste intracanal medicament will be assessed both clinically and radio-graphically for follow-up period up to one year

patients with necrotic teeth with apical periodontitis will be selected according to the eligibility criteria and patients are then randomized to either single visit or multiple visit using triple paste intracanal medicament. postoperative pain will then assessed using numerical rating scale after 1, 2, 3 and 7 days post-instrumentation. radiographic healing will be assessed every 3 months up to one year.

Eligibility criteria:
inclusion criteria: 1. adult patients; age between 16-55 years old. 2. males or females. 3. maxillary or mandibular single-root tooth or a multi-rooted tooth with: * non-vital response of pulp tissue. * radiographic evidence of periapical lesions (minimum size 2.0 mm × 2.0 mm) related to one root in case of multi-rooted teeth. * asymptomatic patients. 4. positive patients' acceptance for participation in the study. exclusion criteria: 1. primary teeth, and permanent teeth with immature apex. 2. teeth previously accessed or endodontically treated. 3. patients with diabetes and immune-compromising disease. 4. patients allergic to metronidazole, ciprofloxacin, or minocycline. 5. vital cases or necrotic without periapical lesion. 6. pregnant women. 7. teeth with unfavorable conditions for rubber-dam application. 8. tooth associated with vertical root fracture, coronal perforation, calcification and external or internal root resorption.
post-ercp pancreatitis prevention by stent insertion

Conditions: Post-ERCP Acute Pancreatitis

Summary: the presented study is designed to analyze the efficacy of pancreatic stent insertion in patients undergoing ercp with accidental cannulation of the pancreatic duct.


Eligibility criteria:
inclusion criteria: * all patients undergoing ercp with unintended cannulation or opifiacation of main pancreatic duct * age \> 17 years * signed informed consent exclusion criteria: * intention to intervene main pancreatic duct * age \< 18 years * pregnancy * absent of signed informed consent

Keywords: ercp endoscopy pancreatitis
interaction study of zanubrutinib with moderate and strong cyp3a inhibitors in participants with b-cell malignancies

Conditions: B-cell Malignancies

Summary: the primary objective of this study was to assess the steady-state zanubrutinib pharmacokinetics (pk) when co-administered with moderate and strong cytochrome p450 family 3 subfamily a (cyp3a) inhibitors.


Eligibility criteria:
key inclusion criteria: 1. histologically or cytologically confirmed cll/sll, mcl, wm, or mzl. 2. relapsed or refractory disease after at least 1 prior line of systemic therapy. participants with mzl are required to have failed an anti-cd20 monoclonal antibody-containing chemotherapy regimen. 3. baseline eastern cooperative oncology group performance status of 0 to 1. 4. meet protocol guidelines for adequate bone marrow, kidney, liver, and cardiac function. key exclusion criteria: 1. requirement of chronic treatment with strong and moderate cyp3a inhibitors or inducers or with drugs that are not allowed to be used in combination with diltiazem, clarithromycin, fluconazole, or voriconazole. 2. history of stroke or intracranial hemorrhage (within 6 months of treatment start). 3. known hypersensitivity or contraindication to zanubrutinib, diltiazem, clarithromycin, fluconazole, or voriconazole. 4. prior exposure to zanubrutinib or other bruton tyrosine kinase inhibitor 5. unable to swallow capsules or disease significantly affecting gastrointestinal function such as malabsorption syndrome, resection of the stomach or small bowel, bariatric surgery procedures, symptomatic inflammatory bowel disease, or partial or complete bowel obstruction. note: other protocol defined inclusion/exclusion criteria may apply.
chronic pelvic pain in endometriosis

Conditions: Endometriosis; Physical Inactivity; Chronic Pelvic Pain Syndrome; Quality of Life

Summary: endometriosis is a chronic, inflammatory disease affecting 10% (1 out of 10) of women of reproductive age. pelvic pain is common among women with endometriosis. women with chronic pelvic pain conditions have elevated rates of relational stress and lower quality of life. the aim of our study is to analyse the extent of pelvic pain associated with endometriosis, as well as the study focuses on correlations between pelvic pain and physical activity, pain-related self-efficacy, perceived stress and different aspects of health related quality of life.

a cross-sectional study was conducted involving women with diagnosis of endometriosis.patients with endometriosis and healthy women as controls are also recruited in the study. the investigators used self-composed questionnaire for evaluating socio-demographic data and life-style factors, gynecological anamnesis, endometriosis diagnosis and further chronic conditions. pain intensity was evaluated using visual analog scale (vas) focusing on perceived pain at present, the avarage perceived pain last month and the most intense perceived pain last month. further measuring instruments were the perceived stress scale (pss) for evaluating stress levels among subjects, sf 36 short form health survey questionnaire for measuring health-related quality of life, global physical activity questionnaire (gpaq) for evaluating physical activity of the subjects, pain catastrophizing scale (pcs) for examining the subjects' perception of and reaction for a painful event, pelvic pain impact questionnaire (ppiq) for evaluating the pelvic pain impact on the subjects' ability to perform physical activity, prolonged sitting, limitations in social activities, sexual activities and intimacy, pain self-efficacy questionnaire (pseq) for evaluating the confidence in performing different activities. the participants are women between 18-50 years old and provided written informed consent. the investigators used convenience sampling method and the data were collected through online surveys. data were analysed using ibm spss 28.0 and microsoft excel 2018 softwares and descriptive statistics, average, mean, standard deviation, two sample t-test, pearson chi square test, kolmogorov-smirnov and shapiro-wilk test. dependent variables were the level of pelvic pain, physical activity, scores on the questionnairies, body mass index (bmi), independent variables were age, diagnosis of endometriosis, educational level. in the course of this study, the cultural adaptation of the pseq questionnaire into hungarian is also carried out based on beaton's guidelines.

Eligibility criteria:
inclusion criteria: * women * for study population: women diagnosed with endometriosis * for control: women not diagnosed with endometriosis * women between 18-50 years old * signed informed consent exclusion criteria: * malignant tumor * current pregnancy

Keywords: endometriosis pelvic pain physical activity chronic pain health related quality of life
biliary drainage preceding possible pancreaticoduodenectomy. are self-expandable metallic stents (sems) superior to plastic stents?

Conditions: Pancreatic Cancer

Summary: this study looks in to the rate of biliary stent dysfunction for plastic and metallic stents in patients who need biliary drainage due to a tumor in pancreas before possible pancreaticoduodenectomy. complications related to the biliary decompression, and possible post-surgical complications in all patients are also recorded. this trial aims to confirm whether metallic biliary stents really are superior to plastic stents as some previous studies suggest. specific patient groups are also evaluated individually to see, whether patients with ongoing cholangitis at the time of diagnosis or patients receiving neoadjuvant treatments have less stent dysfunction cases and complications with metallic stents than with plastic stents.


Eligibility criteria:
inclusion criteria: * resectable tumor of the head of the pancreas * elevated serum bilirubin levels * radiologically visible dilatation of the biliary system exclusion criteria: * distant metastasis * inoperable tumor or other reason, why the patient is unfit for surgery

Keywords: pancreatic cancer biliary decompression