Kornimate/medical-research-clean huggingface dataset:
annexin a2 as a novel diagnostic marker in hepatocellular carcinoma

Conditions: Hepatocellular Carcinoma (HCC)

Summary: this study aimed to investigate the clinical utility of annexin a2 serum level as a novel diagnostic marker of hepatocellular carcinoma (hcc) and to correlate its level with alpha fetoprotein the current marker ofhepatocellular carcinoma (hcc).

this study was carried out in hcc clinic , ain shams university hospitals, cairo; egypt and included :group 1: fifty patients with early stage hepatocellular carcinoma(bclc stage a); group 2:twenty five patients with chronic liver disease diagnosed based on clinical, laboratory, and ultrasonographic investigations; control group: fifteen healthy, age and sex-matched subjects with seronegative hepatitis viral markers .all groups were subjected to thorough history taking, full clinical examination, and laboratory investigations including viral hepatitis markers: hbsag and hcv antibodies using elisa technique and hcv rna using real time pcr for hcv antibody positive patients, afp by electrochemiluminescence and annexin a2 estimation using elisa technique.

Eligibility criteria:
inclusion criteria: * inclusion criteria for hcc cases: 1. confirmed diagnosis of hcc according to the european association of study of liver diseases \[13\]. 2. early stage hcc (stage a), using the barcelona clinic liver cancer (bclc) staging system, (single or 3 nodules \< 3cm ps 0) for all participants:. * informed consent from all participants before enrollment in the study. exclusion criteria: * for hcc patients: 1-imtermediate or advanced stage hcc as defined by bclc 2. major vascular tumor invasion or metastasis confirmed by radiological imaging studies. 3. patients with other suspected solid malignancies or metastatic liver tumors, 4. other types of chronic liver diseases (cld) such as autoimmune hepatitis and primary biliary cirrhosis. * for all participants: * refusal to participate in the study
cardiovascular and neurovascular regulation in gwi

Conditions: Brain Blood Flow; Neurovascular Control

Summary: brain blood flow regulation and autonomic dysfunction will be measured in veterans with and without gulf war illness who served in the gulf war between 1990 and 1992.

gulf war illness (gwi) is a multi-symptom illness with unknown etiology. gwi is a leading cause of disability in gulf war veterans. cognitive complaints are a common symptom of gwi, which suggests the brain is involved in the development of this condition. as veterans age, these cognitive complaints may worsen and be compounded by the aging process. gwi may be a condition of "accelerated" brain aging. therefore, there may be long-term consequences of gwi, and the presence of gwi may increase a person's risk for developing alzheimer's disease (ad) or other dementias. in comparison to other brain-related diseases such as stroke, relatively little is known about gwi and how this condition impacts the normal age-related changes in the brain. the research aims are: 1. to determine if veterans with gulf war illness demonstrate abnormal brain blood flow regulation and autonomic dysfunction when compared with veterans without gulf war illness. 2. to determine if brain blood flow and autonomic nervous system variables in veterans are associated with other markers of brain aging that are relevant to cognitive decline.

Eligibility criteria:
inclusion criteria: * deployed to the persian gulf between 1990-1992 * body mass \<300 lbs * diagnosis of gulf war illness based on cmi/cdc and kansas definitions or no diagnosis of gulf war illness exclusion criteria: * current or lifetime evidence of: type ii diabetes, neurological disease, cancer treatment, rheumatoid arthritis, lupus, bipolar disorder, psychotic disorders, or mood disorders with psychotic features * current illicit substance use or partial remission for less than 1 year * taking multiple sedatives or anticonvulsant medications * currently pregnant * absolute contraindications to exercise testing * contraindications to mri * other significant medical conditions at investigator's discretion

Keywords: mri brain blood flow sympathetic nerve activity cardiorespiratory fitness
pilates exercises and down syndrome

Conditions: Balance; Down Syndrome; Pilates Exercises

Summary: down syndrome is one of the genetic disorders that affect postural control and balance in children. balance involves controlling the position of the body in space to achieve stability and orientation. pilates exercises are one of several techniques that are used to improve balance and postural control in adults and children. the purpose of the study is to investigate the effect of pilates exercises on balance and gross motor co-ordination in children with down syndrome

group a performed flexibility, strength, and endurance exercises that focused on the lower extremity and trunk muscles, exercise for postural stability in various positions and surfaces, including flexibility exercises for the hip, knee and calf muscle. strengthening exercises included the core muscles, hip abductors, hip extensors hamstrings and quadriceps knee extension in high sitting. postural control involved walking in all directions, exceeding the limits of stability in various positions such as kneeling, half kneeling, standing on rough and soft surfaces, each session started with a warming up and cooling down of 5 minutes for each period and each session lasted for 45 minutes. group b received the same program of exercises given to group a in addition to 45 minutes of pilates exercises to improve balance and gross motor coordination. exercises were performed on a mat, a medical ball, and from a standing position, focusing on maintaining core contraction, spinal and pelvic alignment, and respiration rhythm. ten repetitions of pilates exercises will be performed with a 2-minute rest period between repetitions. both groups will attended the intervention program three times/week for 3 months

Eligibility criteria:
inclusion criteria: * (1) diagnosed with trisomy 21 through genetic testing, (2) aged 6 to 11 years and (3) able to follow a minimum of two-step instructions. the minimum motor ability of participants with ds was independent locomotion. exclusion criteria: * (1) medical condition that is contraindicated to moderate to vigorous physical activity such as cardiovascular problems, (2) orthopaedic instability, including those associated with ds (e.g. atlanto-axial instability) and (3) behavioural issues that hindered instruction.
polish version fatigue severity scale

Conditions: Multiple Sclerosis; Amyotrophic Lateral Sclerosis; Stroke, Ischemic

Summary: fatigue is one of main symptoms in multiple sclerosis, amyotrophic lateral sclerosis and other diseases with profound effect on quality of life and professional and social functioning. not infrequent it is misdiagnosed as sleepiness or other symptom. fatigue severity scale is a time efficient and easy to apply instrument to assess the impact of fatigue on patient's life. the aim of this study is to validate the polish-language version of the fatigue severity scale.

fatigue is one of main symptoms in multiple sclerosis, amyotrophic lateral sclerosis, post-polio syndrome, stroke, parkinsonism as well as in the chronic fatigue syndrome. it has profound effect on quality of life and professional and social functioning and in multiple sclerosis it is described as the worst symptoms by the 50% of patients. it is defined as the difficulty in initiating and maintaining a sustained mental or physical activity. not infrequent it is misdiagnosed as sleepiness or other symptom. fatigue severity scale (fss) is a time efficient and easy to apply instrument to assess the impact of fatigue on patient's life. it has been translated and validated in turkish, russian, hindi, portuguese, and many other languages. fss is a short, nine-item self-report questionnaire. each item is a likert scale, scored from one to seven, where seven refers to the most severely expressed aspect of fatigue. the aim of this study is to validate the polish-language version of the fatigue severity scale (pfss). this version has been created according to widely accepted, respective standards, including translation by two independent native polish-language speakers with acquired knowledge of english and backward translation by two independent native english-language speakers with acquired knowledge of polish as well as with the pretesting on ten patients.

Eligibility criteria:
inclusion criteria: * diagnosis of definite multiple sclerosis or definite, laboratory-supported multiple sclerosis, or definite amyotrophic lateral sclerosis, or probable amyotrophic lateral sclerosis or probable, laboratory supported amyotrophic lateral sclerosis or ischemic stroke or - for healthy controls - lack of diseases, pharmacotherapy or habits, which could induce abnormal tiredness exclusion criteria: * presence of cognitive deficits or behavioral disorder, which could disturb participation in the study.

Keywords: fatigue multiple sclerosis stroke quality of life
assessment of what patients and healthcare providers value

Conditions: Gastric Adenocarcinoma; Pancreatic Adenocarcinoma; Pancreatic Neuroendocrine Carcinoma

Summary: to assess the importance patients place on each of the attributes of value (i.e., outcomes, quality of life \[qol\], cost, experience), and how these patientsâ€™ views differ depending on the stage of their therapy (pretreatment, preoperative therapy, post-operative, long-term surveillance, recurrence).

primary objective: i. to assess the importance patients place on each of the attributes of value (i.e., outcomes, quality of life \[qol\], cost, experience). secondary objectives: i. to assess which attributes of value (i.e., outcomes, qol, cost, experience) health care providers (i.e., physicians, nurses, administrators) feel are most important in health care delivery. ii. to assess how these patients' views differ depending on the stage of their therapy (pretreatment, preoperative therapy, post-operative, long-term surveillance, recurrence). iii. to assess how patients' view differ to health providers. outline: patients and healthcare providers complete a survey over 10-15 minutes.

Eligibility criteria:
inclusion criteria: * any patient who has been treated, or is anticipated to be treated, for potentially resectable, biopsy-proven pancreatic adenocarcinoma, pancreatic neuroendocrine malignancy, or gastric adenocarcinoma * providers involved in the care of gastric and pancreatic cancer patients. providers will include non-collaborative surgical oncologists, medical oncologists, radiation oncologists, administrators, nurses, mid-level providers * able to understand the description of the study and willing to participate exclusion criteria: * inability to read and answer questions in english
cognitive groove (brought to you by geras dance)

Conditions: Frailty; Frail Older Adults; Frailty in Aging; Frailty Syndrome

Summary: the goal of this clinical trial is to determine the effect of a community-based rehabilitation intervention (cognitive groove, brought to you by geras dance), compared to usual care, on clinical outcomes in community-dwelling older adults living with frailty. the main questions it aims to answer are: 1. in community-dwelling older adults living with frailty, is cognitive groove more effective than usual care in improving functional movement, physical performance and strength? 2. in community-dwelling older adults living with frailty is cognitive groove more effective than usual care in improving frailty status, fear of falling, balance confidence, mood, cognition, grip strength, activities of daily living, life space mobility, loneliness, and quality of life? 3. as a community-based rehabilitation intervention, is cognitive groove a cost-effective intervention embedded within the community for older adults living with frailty after 12-months? participants will participate in cognitive groove classes twice per week for 3 months or receive no intervention (usual care).


Eligibility criteria:
inclusion criteria: * community-dwelling aged ≥65 years * at high risk for mobility disability/functional limitations as assessed by the frail scale ≥2 * able to ambulate independently (25 m) with or without an assistive device * able to follow two-step instructions * medical clearance from referring clinician, or for self-referrals, medical clearance from family physician to safely participate in exercise * can arrange transportation to the ymca up to 2 times per week exclusion criteria: * unable to speak or understand english * current regular participation in a structured exercise program or receiving active physical therapy services * severe cardiac or pulmonary disease * unstable angina or heart failure * severe osteoarthritis (e.g., awaiting joint replacement) * parkinson's disease or other progressive neurological disorder * receiving palliative care * travel/commitments requiring missing more than two weeks

Keywords: frailty rehabilitation dance
laparoscopic versus open pyloromyotomy for infants with idiopathic hypertrophic pyloric stenosis

Conditions: Hypertrophic Pyloric Stenosis

Summary: pyloric stenosis is a condition that develops in infants and that leads to an obstruction of the channel going out of the stomach. this study is being performed to determine if there is an advantage to the laparoscopic approach or the open approach for the surgical correction of the enlarged pylorus.

pyloromyotomy for pyloric stenosis has traditionally been performed via an open technique. with advancements in minimally invasive surgery in infants a laparoscopic approach has been developed. these two approaches have never been critically evaluated with regard to superiority of one technique over the other. this is a prospective randomized trial involving infants with pyloric stenosis. it will enroll 100 patients in each arm (statistical and power analysis was performed by steve simon, phd). parental consent will be obtained and the patients will be randomized to undergo open or laparoscopic pyloromyotomy. patient age at diagnosis, electrolyte disturbances at diagnosis, ultrasound findings, operative approach, length of pyloromyotomy, operative times, time to tolerating full feeds, number of emesis episodes, length of hospitalization, operative charges, and hospital charges will be collected for comparison between the groups.

Eligibility criteria:
inclusion criteria: * all infants less than 12 weeks of age who have undergone surgical consultation and abdominal ultrasound confirming the diagnosis of pyloric stenosis and whose parents have given consent for inclusion in the study. exclusion criteria: * all patients greater than 12 weeks of age, or without parental consent, or without pyloric stenosis will be excluded from the study.

Keywords: pyloric stenosis laparoscopy idiopathic hypertrophic pyloric stenosis
safety study of four candidate influenza vaccines to prevent influenza disease in the elderly population

Conditions: Influenza

Summary: as influenza vaccine efficacy is reported to be lower in elderly subjects compared to healthy adults, probably as a result of immunosenescence, there is a desire to devise ways to increase the current vaccines efficacy for this target population. adjuvants are known to boost immune responses, thus representing one way to increase the efficacy of the current glaxosmithkline fluarix™ influenza vaccine in elderly subjects. the purpose of this study is to evaluate the immunogenicity and the reactogenicity of a vaccination with four different adjuvanted glaxosmithkline influenza vaccines administered to elderly subjects. for immunogenicity and safety evaluations, healthy adults aged 18 to 40 years old and elderly aged 65 years and older will receive fluarix™ and form the control groups of this trial.


Eligibility criteria:
inclusion criteria: * a male or female aged between 18 and 40 years or aged 65 years or older at the time of the vaccination. * free of obvious health problems as established by medical history and clinical examination before entering into the study. exclusion criteria: * use of any investigational or non-registered product (drug or vaccine) other than the study vaccine(s) within 30 days preceding the administration of the study vaccine, or planned use during the study period. * chronic administration (defined as more than 14 days) of immunosuppressants or other immune-modifying drugs within six months prior to the administration of the study vaccine. * history of confirmed influenza infection since a year from the date of previous vaccination. * any confirmed or suspected immunosuppressive or immunodeficient condition, based on medical history and physical examination * history of hypersensitivity to vaccines. * history of allergic disease or reactions likely to be exacerbated by any component of the vaccine. * acute clinically significant pulmonary, cardiovascular, hepatic or renal functional abnormality, as determined by physical examination or laboratory screening tests. * acute disease at the time of enrolment. * administration of immunoglobulins and/or any blood products within the three months preceding the administration of the study vaccine or during the study.
study of anti-hiv cellular therapy based on dendritic cells pulsed with chemically inactivated virus

Conditions: HIV Infection

Summary: the aim of this study was to assess tolerability and safety of three different formulations of an anti-hiv immunotherapy based on autologous dendritic cells (dcs) pulsed with hiv chemically inactivated with aldrithiol™-2 (at-2). patients were chronically infected with hiv, naïve for antiretroviral drugs. a possible immunological and virological favorable impact was also assessed.


Eligibility criteria:
inclusion criteria: * patients with hiv infection; * absence of antiretroviral therapy, antineoplastic therapy or the use of corticosteroids for at least six months prior to study entry; * plasma viral load ≥ 1,000 copies / ml, stable (ie no variation \> 0.5 log) in the six months before the start of the study; * blood cd4+ t cells ≥ 350 /ml, stable (ie no variation \> 25%) in the six months before the start of the study. exclusion criteria: * individuals without proper venous access for blood and apheresis collection procedure. * use of drugs, alcohol, psychiatric disorder or any condition that interferes with the ability of patients to follow the requirements of the study; * history of diagnosis of hiv infection \<01 years; * pregnancy or breast-feeding; * use of antiviral therapy, in anticancer therapies or corticosteroids six months prior to study start; * presence of chronic diseases, such as infection with hepatitis b (hbv) and c (hcv), human t-lymphotropic virus (htlv) i / ii or any condition that promotes immune system dysfunction, with the exception of hiv infection.

Keywords: hiv immunotherapy clinical trial dendritic cell
combining rtms and video game-based dexterity training to improve dexterity in parkinson's disease

Conditions: Parkinson Disease

Summary: we investigate the effectiveness of a combined repetitive transcranial magnetic stimulation (rtms) - video game-based training (vbt) dexterity intervention in parkinson's diseases. the short and long-term benefits of this training program will be evaluated. for these purposes, a blinded sham controlled randomized controlled trial will be performed.

patients with parkinson's disease (pd) often exhibit dexterous difficulties during the performance of activities of daily living (adl) such as tying shoe laces, hand-writing, using remote controls, smartphone or tablet. these difficulties further add to the burden of the disease, leading to reduced quality of life (qol). a relatively new, but rapidly growing aspect of training in pd neurorehabilitation is exergaming. to enhance training effects a combination of repetitive transcranial magnetic stimulation (rtms) with exergaming will be tested.

Eligibility criteria:
inclusion criteria: 1. confirmed pd 2. hoehn \& yahr i to iv 3. age 50-80 years old 4. written and signed informed consent 5. dexterous difficulties- exclusion criteria: 1. significant medical, psychiatric co-morbidity including dementia as defined by montreal cognitive assessment (moca \< 21) 2. inability to understand the scope of the study and to follow study procedures according to the protocol e.g. complete questionnaires (i.e. due to cognitive problems) 3. exclusion criteria for tms and sham application, such as current pregnancy, personal history of epilepsy or epileptic fits, and any psychiatric, neurologic, or medical history. 4. participation in another interventional trial.

Keywords: transcranial magnetic stimulation dexterity video game-based training
hypertension in management of military medicine

Conditions: Hypertension

Summary: this study is a retrospective database review of primary care appointments of patients' charts with new diagnoses of hypertension.

compare the degree of blood pressure control of patients with stage 1 (bp \ 20/10 mm hg above goal bp) before and after the release of the seventh report of joint committee on prevention, detection, evaluation and treatment of high blood pressure (jnc 7) recommendations.

Eligibility criteria:
inclusion criteria: * newly diagnosed hypertension

Keywords: hypertension
interpersonal psychotherapy for treatment resistant depression

Conditions: Treatment Resistant Depression

Summary: the purpose of this study is to determine whether combination of antidepressant drugs plus interpersonal psychotherapy is superior to antidepressant drugs alone in treatment resistant depression.


Eligibility criteria:
inclusion criteria: * primary diagnose of unipolar treatment resistant depression exclusion criteria: * patients diagnose of: bipolar disorder, psychosis, high suicide risk, intellectual disability, illicit drug dependence. * currently in or having received psychotherapy in the last 4 weeks

Keywords: psychotherapy, treatment resistant depression, depression
collaborative redesign of implementation strategies for the brief intervention for school clinicians

Conditions: Anxiety Disorders; Depressive Symptoms; Mental Health Issue

Summary: schools are the most common venue for youth mental health services, but school mental health (smh) typically does not use evidence-based clinical interventions (ci), common elements of effective mental health, or effective implementation strategies. to address this gap, a multidisciplinary team developed the brief intervention for school clinicians (brisc), a four-session engagement, brief intervention, and triage strategy targeting a range of mental health (e.g., anxiety, depression, past trauma) and other problems (academic, peer, family). brisc outperformed smh usual care on engagement, treatment completion, and youth self-reported problem severity. although there are many evidence-based smh strategies such as brisc, integration into practice is poor because accompanying implementation strategies are often absent, poorly defined, or insufficiently tailored to the education context.

the investigators will evaluate the impact of original brisc (br-o) implementation versus adapted brisc (br-a) implementation for students referred to smh on mental health outcomes (i.e., student top problems, anxiety, depression, mental health functioning). the investigators hypothesize: h-1: in both br-o and br-a, more students will experience clinical improvement on mental health outcomes (i.e., top problems, anxiety, depression, mental health functioning) than deteriorate or remain unchanged. h-2: br-a will demonstrate noninferiority to br-o on mental health outcomes.

Eligibility criteria:
inclusion criteria: * clinician participants: counselors will be included if they (a) provide school-based services; (b) have not previously received formal training in brisc; and (c) are not actively receiving support to implement another intervention. * youth participants: students must meet eligibility criteria for brisc including (a) being in grades 9-12 and 13 years or older (b) receiving school mental health services exclusion criteria: * anyone not meeting inclusion criteria.

Keywords: school mental health