Kornimate/medical-research-clean huggingface dataset:
comparison of progel sealant to standard of care (soc) for patients undergoing decortication

Conditions: Lung Diseases; Mesothelioma

Summary: the goal of this clinical research study is to compare progel® (a type of surgical sealant that is made from human blood products) to the standard of care (talcum powder) to learn if one method is better than the other for preventing air leaks in patients having a pleurectomy decortication.

if participant agrees to take part in this study, they will have their pleurectomy decortication as planned. participant will sign a separate consent for this procedure that explains the risks. at the time of participant's surgery, sutures and staples are used to help correct air leaks, which is standard. then, participant will be randomly assigned (as in the flip of a coin) to 1 of 2 study groups. this is done because no one knows if one study group is better, the same, or worse than the other group: * one group will have progel® added to the surface of the lung before closing the chest. * the other group will have talcum powder added to the surface of the lung before closing the chest. participant will have an equal chance of being in either group. during the surgery, air leaks will be checked electronically and that information will be recorded. after surgery, participant will be asked to rate their pain on a pain scale of 0-10. participant will be asked to complete this pain scale 3 times each day while they are in the hospital. length of study participation: after participant's surgery and their air leak is resolved, their participation in this study will be over. this is an investigational study. the progel® surgical sealant is fda approved for the control of air leaks during lung surgery. it is investigational to compare the surgical sealant with the standard-of-care (talcum powder) to learn if it can reduce the number of days in the hospital after surgery. up to 48 participants will enrolled in this study. all will take part at md anderson.

Eligibility criteria:
inclusion criteria: 1. all patients with mesothelioma or other pathologies undergoing a pleurectomy decortication at md anderson cancer center 2. adequate preoperative renal function documented by serum creatinine of \ 50 ml/min exclusion criteria: 1. patients unable to consent for the procedure 2. patients with a history of allergy to human proteins 3. patients who may have insufficient renal capacity for clearance of progel® polyethylene glycol load

Keywords: lung diseases mesothelioma pleurectomy decortication progel talcum powder pain questionnaires surveys intraoperative air leaks ial
sub lingual versus traditional oral administration of ticagrelor in acute coronary syndrome/non st-elevation myocardial infarction - a platelet reactivity study

Conditions: Acute Coronary Syndromes; Non ST Elevation Myocardial Infarction

Summary: our goal is to examine sub lingual versus traditional oral administration of ticagrelor in acs/non st-elevation myocardial infarction (nstemi) patients on platelet reactivity.


Eligibility criteria:
inclusion criteria: 1. patients presenting with acs/nstemi 2. informed, written consent exclusion criteria: 1. age \ 90 years 2. active bleeding; bleeding diathesis; coagulopathy 3. increased risk of bradycardiac events 4. history of gastrointestinal or genitourinary bleeding \<2 months 5. major surgery in the last 6 weeks 6. history of intracranial bleeding or structural abnormalities 7. suspected aortic dissection 8. any other condition that may put the patient at risk or influence study results or investigator's opinion (severe hemodynamic instability, known malignancies or other comorbid conditions with life expectancy \<1 year) 9. administration in the week before the index event of clopidogrel, ticlopidine, prasugrel, ticagrelor, thrombolytics, bivalirudin, low-molecular weight heparin or fondaparinux. 10. concomitant oral or iv therapy with strong cyp3a inhibitors or strong cyp3a inducers, cyp3a with narrow therapeutic windows 11. known relevant hematological deviations: hb \<10 g/dl, plt\<100x10\^9/l 12. use of coumadin derivatives within the last 7 days 13. chronic therapy with ticagrelor, prasugrel, clopidogrel or ticlopidine 14. known severe liver disease, severe renal failure 15. known allergy to the study medications 16. pregnancy 17. human immunodeficiency virus treatment

Keywords: nstemi
a study comparing geriatric co-management with geriatric guided supportive care in older patients receiving chemoradiation therapy for their head and neck cancer

Conditions: Head and Neck Cancer

Summary: the researchers are doing this study to see whether geriatric co-management or geriatric guided supportive care are good approaches for managing side effects in older patients who have head and neck cancer and are receiving chemoradiation therapy. this study will provide valuable information about different ways to manage side effects in older patients receiving chemoradiation therapy.


Eligibility criteria:
inclusion criteria: * age ≥ 65 * pathologically (histologically or cytologically) diagnosis of head and neck cancer of oral cavity, oropharynx, larynx, or hypopharynx * patient will receive a 6 to 7 week course of intensity modulated radiation therapy and concurrent chemotherapy either in definitive or post-operative setting * able to read and understand english * able to provide informed consent exclusion criteria: * patients who have previously consulted with or are followed by a geriatrician * inability to use telemedicine if unable to present to clinic visits in person * inability to complete the erfa (patient is unable to comprehend or answer questions included on the erfa) * treatment with proton therapy * patients on therapeutic clinical trials of experimental therapies or those not receiving standard of care

Keywords: supportive care older patients with head and neck cancer receiving radiation and chemotherapy 22-016
motor learning through virtual reality task in individuals with down syndrome

Conditions: Down Syndrome

Summary: background: down syndrome (ds) has unique physical, motor and cognitive characteristics. despite cognitive and motor difficulties, there is a possibility of intervention based on the knowledge of motor learning. however, it is important to study the motor learning process in individuals with ds during a virtual reality task to justify the use of virtual reality to organize intervention programs. the aim of this study was to analyze the motor learning process in individuals with ds during a virtual reality task. methods: a total of 40 individuals participated in this study, 20 of which were with ds (24 males and 8 females, ranging between 11-28 yrs.) and 20 typically developing individuals matched by age and gender to the individuals with ds. to examine this issue, we used software that uses 3d images and reproduced a coincidence timing task.


Eligibility criteria:
inclusion criteria: * medical diagnosis of ds and the ability to understand the task. exclusion criteria: * disorders in cognitive function that would prevent comprehension of the experimental instruction

Keywords: virtual reality
subcutaneous daptomycin in healthy volunteers (daptosc)

Conditions: Antibiotics; Subcutaneous Injection; Daptomycin

Summary: background: multidrug-resistant bacteria are a major public health problem worldwide, notably due to excess mortality and an increase in the length of hospital stay. antibiotics that can be used to treat these infections are limited. daptomycin is one of the most widely used antibiotics for the treatment of infections with gram-positive bacteria, such as methicillin-resistant staphylococcus aureus (mrsa). however, it is only administered intravenously (iv). it is therefore interesting to find new routes of administration in order to widen the possibilities of using daptomycin, especially in people who have difficulties with the venous approach. methods/design: in a randomized, single blinded, crossover, noninferiority study in the chu of caen, the investigators aim to demonstrate the pharmacokinetic bioequivalence between the subcutaneous and the intravenous route of daptomycin in healthy volunteers. they will conclude the bioequivalence if the confidence interval of the area under the curve obtained is entirely within the interval \[80% - 125%\]. discussion: this clinical trial could, if bioequivalence is demonstrated, lead to the completion of a clinical trial in infected patients in order to assess the efficacy and safety of daptomycin by the subcutaneous route.


Eligibility criteria:
inclusion criteria: * healthy volunteer from 18 to 65 years old * subject determined in good health by a doctor * signature of free and informed consent * affiliated to the french healthcare insurance * fluent in french exclusion criteria: * active bacterial or viral infection * immunocompromised * body mass index \ 30 kg / m2 * kidney failure with glomerular filtration rate \<90ml / min / m2 calculated according to the ckd-epi method * known or suspected liver disease * pregnant or lactating woman * guardianship or curators * any situation that could interfere with the self / hetero assessment of pain (dementia, psychiatric disorders, for example) * concomitant intake of myotoxic drugs (statins, fibrates, ciclosporin, for example) * allergy or known side effects to daptomycin * dermatological pathologies which may interfere with the subcutaneous injection (eczema, psoriasis, etc.) * localized tattoo or piercing on the abdomen which may interfere with the subcutaneous injection or the evaluation of possible local effects of the injection * parenteral exposure to daptomycin in the previous 30 days * the inclusion of the subject in another interventional research protocol (during the present study and in the 3 months before inclusion).
treatment modification to reduce symptom burden in hemodialysis

Conditions: End Stage Renal Disease

Summary: many patients on hemodialysis experience high rates of symptom burden, such as pain, depression, anxiety and difficulty breathing. this study seeks to reduce these symptoms by modifying the usual guidelines used to manage patients on hemodialysis. for example, rather than trying to keep serum phosphorus below 5.5, patients enrolled in this study may have treatment goals of less than 6.5, in order to reduce the number of pills they need to take and potentially reduce harmful side effects. blood pressure and serum parathyroid hormone goals will also be modified, to see if these modifications help hemodialysis patients feel better.


Eligibility criteria:
inclusion criteria: * hemodialysis patient * transplant ineligible exclusion criteria: * dementia * unable to answer questionnaires for any reason
maximizing treatment outcome in post-traumatic stress disorder (ptsd)

Conditions: Post-Traumatic Stress Disorder

Summary: the purpose of this study is to examine the efficacy of exercise + therapy to therapy alone to determine if they can improve the effects of prolonged exposure therapy (pe) in reducing symptoms of anxiety associated with post-traumatic stress disorder (ptsd). in addition the two strategies (i.e., exercise + therapy and therapy alone condition) will be compared in terms of levels of brain-derived neurotrophic factor (bdnf). bdnf is a protein that helps to support the survival of existing neurons and stimulate the growth of new neurons and synapses. bdnf is important to learning and memory in general and therefore may be associated with the learning and memory as it relates to pe and corresponding symptoms ptsd improvement.


Eligibility criteria:
inclusion criteria: * you have ptsd. * you are between the ages of 18 and 65. * you have written physician approval/medical clearance to participate in an exercise protocol. * you are currently taking no psychotropic medications or are able and willing to discontinue these medications prior to the first pe session. exclusion criteria: * you are currently participating in a structured exercise program. * you have severe depression. * you have any history of bipolar disorder, psychotic disorder, or obsessive compulsive disorder. * you have a diagnosis of eating disorder, or substance abuse or dependence (excluding nicotine) within the past six months. * you have any history of a suicide attempt, or are at a significant risk or self-harm or harm to others. * you have ever been diagnosed with organic brain syndrome, mental retardation, or other cognitive dysfunction.

Keywords: ptsd anxiety behavior therapy prolonged exposure exercise wellness post-traumatic stress
human epidemiology of newly identified arboviruses

Conditions: Arbovirus Infections; SARS-CoV Infection

Summary: a local network is being set up to study the impact of arboviruses in our region. it is committed to a one-health approach, in particular with research without a priori for new viruses hosted among vectors and wildlife. the candidates identified by high throughput sequencing approaches will serve as a basis for the development of serological and molecular tools for their detections. these tools will be used to assess the possible circulation of these new viruses in humans in biological collections created within the framework of this project arbodocc .


Eligibility criteria:
inclusion criteria: - patients admitted at the monpellier university hospital for any infectious syndrome compatible with an arboviral infection with samples available exclusion criteria: - informed consent non obtain for samples used

Keywords: patients with arboviral infection compatible signs unexplained isolated fever neurological infection conditions without any identified etiology arbovirus arboviral like infectious disease
photoplethysmography detects changes in vascular tone

Conditions: Vascular Diseases

Summary: changes in the vascular tone of anesthetized patients is common and cause hemodynamic problems. the monitoring of such changes in vascular resistance using simple and non-invasive tools is lacking. the present study was designed to determine if photoplethysmography can detect changes in the systemic vascular resistance using doppler as the reference method.

this is a prospective and observational study designed to test the reliability of photoplethysmography to diagnose changes in the vascular resistance during anesthesia. the investigators will studied 50 mechanically ventilated patients undergoing general anesthesia. photoplethysmography will be continuously recorded in the right thumb during anesthesia. duplex color and power doppler will measure flow in the radial artery of the right hand.the contour analysis of both, photoplethysmogram and radial artery flow will be analyzed, correlated and compared using the bland-altman plot.

Eligibility criteria:
inclusion criteria: * written inform consent * programmed surgery * supine position exclusion criteria: * emergency surgery * peripheral vascular diseases
abnormal eating and taste perception in subjects with obesity

Conditions: Obesity

Summary: the identification of safe and effective strategies for weight loss and long-term maintenance is critical to reduce the alarming prevalence of obesity worldwide and mitigate obesity-associated health risks. specifically, binge eating (be) and food addiction (fa) behaviors are well known causes of failed weight loss and weight regain. the definitions of their clinical phenotypes are currently evolving. recent evidence suggests that food choices, behavior and reward may be driven also by taste perception. the hypothesis of this study is that subjects with dysfunctional eating behavior have different taste thresholds compared to obese subjects without eating disorders, and that this characteristic influences food choice and eating behavior. identifying a difference in the taste thresholds between obese with and without eating disorder will allow us to understand why certain individuals over-consume or binge on densely caloric foods and to give them a tailored dietary treatment so as to maintain weight loss for a long time. the binge eating and food addiction is assessed using binge eating scale and yale food addiction scale 2.0. subjects with obesity recruited are divided in 4 groups: without eating disorder, with food addiction (fa), with binge eating (be) and with fa + be. in these groups sweet and salty taste will be measured with the 3-alternative-forced-choice method.


Eligibility criteria:
inclusion criteria: * bmi\>30 kg/m2 and \<45 kg/m2 exclusion criteria: * uncooperative patients * heavy smokers * pregnancy or recent (in the last 6 months) childbirth * thyroid disorders * presence of endocrine abnormalities associated with obesity * current or recent oral, nasal or sinus infections * major psychiatric disorder even in pharmacological compensation * patients who had undergone bariatric surgery

Keywords: taste; obesity; food addiction; binge eating; sweet; salty
establishing normal values for neuropsychological testing in hiv-negative thais

Conditions: HIV Infections

Summary: the purpose of this study is to establish normal values for neuropsychological testing in hiv negative thais stratified by age (1 decade) and education (no certificate or primary school certificate, less than high school certificate or vocational certificate, high school certificate or higher vocational certificate or diploma, bachelor degree or higher.

the southeast asia research collaboration with hawaii (search) operates or collaborates on several neuroaids research protocols. to allow accurate interpretation of neuropsychological data, normative data that are obtained in a similar population are needed. currently, there are limited such data available for this purpose. the search 001 study evaluated the neurocognitive changes before and after highly active antiretroviral therapy in 30 hiv positive subjects and has also enrolled 230/300 proposed hiv-negative controls for this purpose. normative data tables typically require many more individuals so that age and education strata can be established. we now propose to enroll up to 1000 hiv-seronegative individuals for this purpose.

Eligibility criteria:
inclusion criteria: 1. age 20-69 2. male or female 3. negative hiv antibody at screening 4. have the ability to understand the study and signed the informed consent form exclusion criteria: 1. head injury with loss of consciousness greater than 1 hour 2. current or past illicit drug use or positive drug screen for amphetamine, methamphetamines, cocaine, marijuana, or narcotics 3. severe illness within 30 days prior to entry 4. current or recent fevers or meningeal signs. 5. history of pre-existing neurologic disease to include stroke, multiple sclerosis or autoimmune disease. 6. active major depression will be excluded as well - patients with past depression that is controlled and patients with or minor depressive symptoms will be allowed to enroll. 7. known learning disability including dyslexia 8. confusion or other signs and symptoms of metabolic encephalopathy or delirium 9. focal neurological deficit on examination 10. examining physician's concern that participant may not be able to complete visit requirements.

Keywords: hiv-negative
perioperative dexamethasone on postoperative outcome in ibd

Conditions: Inflammatory Bowel Diseases; Dexamethasone; Postoperative Ileus; Postoperative Complications

Summary: the objective of this rct is to determine the efficacy of a single preoperative dose of dexamethasone for accelerating the recovery and reducing the incidence of postoperative complications in adult patients undergoing intestinal resection for inflammatory bowel disease.

patients undergoing surgery for ibd is associated with increased inflammatory response and incidence of prolonged ileus after surgery compared to other colorectal disease such as crc. previous studies have revealed that preoperative administration of glucocorticosteroids(gcs) decreased complications and length of postoperative length of hospital after major abdominal surgery as a likely consequence of attenuating the postsurgical inflammatory response. also, a single dose of gcs did not increase complications in colorectal surgery. the aim of the study is to examine whether a single dose of dexamethasone prior to induction of anesthesia could promote the recovery of patients and reduce the incidence of prolonged ileus after surgery for ibd

Eligibility criteria:
inclusion criteria: 1. patients undergoing elective open and laparoscopic small and large bowel operations for ibd, including crohn's disease(cd) and ulcerative colitis (uc). 2. asa i-iii exclusion criteria: 1. diabetes or hyperglycemia 2. active gastric ulceration confirmed endoscopically 3. presence of ongoing infection (such as ias) or infective chronic diseases 4. currently receiving systemic therapy with glucocorticoids with prednisolone \>=20mg for over 6 weeks within 30 days prior to surgery. 5. emergent surgery 6. acute angle glaucoma 7. pregnancy 8. under 18 years of age 9. known adverse reaction to dexamethasone 10. extensive adhesiolysis 11. carcinogenesis of intestinal tract

Keywords: inflammatory bowel diseases glucocorticosteroids postoperative outcome
gonyautoxin in the treatment of chronic tension-type headache

Conditions: Tension-Type Headache

Summary: the purpose of this study is to evaluate the clinical efficacy of gonyautoxin 2/3 epimers in the treatment of patients diagnosed with chronic tensional-type headache in accordance with international headache society guidelines

gonyautoxin are phycotoxins, whose molecular mechanism of action is a reversible block of the voltage-gated sodium channels at neuronal level. they are axonal conduction blockers impeding nerve impulse propagation. in order to evaluate the clinical efficacy of gonyautoxin 2/3 epimers in the treatment of patients diagnosed with chronic tensional-type headache, the patients were locally injected with placebo versus gonyautoxin following a painful spots injection standarized protocol

Eligibility criteria:
inclusion criteria: * chronic tensional-type headache patients according to the international headache society criteria: patients with headache of a pressing or tightening quality with episodic frequency above 15 days a month * refractory to conventional treatments such as, orally administered analgesics, systemic muscular relaxant, corticoids and antidepressant like amytriptiline * treated and controlled in the university hospital neurology clinic over 2 years with duration of symptoms over 3 years exclusion criteria: * pregnancy * use of headache prophylactic treatment a month prior to infiltration * myasthenic syndromes * muscular dystrophies * inflammatory myopathies * acute and chronic polineuropathies * use of psychotropic substances 24-hour before infiltration * anticoagulant treatment * terminal illnesses (aids, cancer) * drugs or alcohol abuse

Keywords: gonyautoxins tension-type headache human treatment