Kornimate/medical-research-clean huggingface dataset:
anterior capsulo-labral reinsertion by arthroscopic approach versus immobilization

Conditions: Bankart Lesion

Summary: the risk of recurrence and chronic instability after an initial episode of anterior glenohumeral dislocation is high, the risk is higher the younger the patient is. most patients with recurrences develop this instability during the first 2 years. several studies have shown that an initial arthroscopic surgical treatment (bankart intervention) decreased the risk of recurrence and therefore of chronic instability, but this attitude is not usual in france and none randomized study comparing intervention of arthroscopic bankart and immobilization was published by a french team. the primary objective was to evaluate at 2 years the efficacy on the rate of recurrent instability of the first-line arthroscopic repair of prior capsulo-labral lesions compared to conservative treatment by immobilization for patients under 25 years having an initial episode of anterior glenohumeral dislocation material and method : we conducted a randomized controlled, open-label, parallel-group study (conservative treatment group by immobilizing vs surgical treatment group) in patients aged 18 to 25 with anterior glenohumeral primo luxation. patients were clinically reassessed at 2 years with functional scores (wosi, duplaywalch, dash), mobility and instability recurrence. hypothesis: reduction of the recurrence rate in the surgically treated group


Eligibility criteria:
inclusion criteria: * patients with inclusive on the day of dislocation. * first episode of anterior glenohumeral dislocation without associated humeral fracture confirmed by a standard radiograph. exclusion criteria: * dislocation without trauma, in a context of hyper laxity with a beighton score ≥4 / 97.8. in these patients post-dislocation mri was performed in the robinson study, which found no capsulo-labral lesion. * bone glenoid defect\> 25% at the scanner (bony bankart). * delay greater than 15 days between luxation and surgical treatment * against indication to anesthesia * pregnant or nursing women

Keywords: glenohumeral dislocation arthroscopic capsular lesions
retrospective analysis of spinal cord stimulation on chronic non-cancer pain

Conditions: Chronic Pain

Summary: since 2014, the queen mary hospital, a tertiary teaching hospital in hong kong, has commenced the provision of spinal cord stimulation (scs) services with structured guidelines, standardized protocols and comprehensive pre- and post-operative assessments. it is hoped that the needs of chronic pain patients, especially those who are refractory to conventional medical management, can be better addressed with the introduction of scs. hence, through the proposed retrospective study, the investigator aim to systematically evaluate the use of scs in queen mary hospital, thereby providing evidence with regard to its efficacy and safety for pain management.

as one of the most common health complaints in the world, low back pain (lbp) can affect people across all age groups, with a lifetime prevalence of 84%. in hong kong lbp is reported to be the second most prevalent illness due to work and the most common illness made worse by work. lbp can be acute or chronic, with the former lasting less than six weeks and the latter lasting more than twelve weeks. lbp is believed to have an adverse impact on quality of life and functional performance, creating social and economic costs. current guidelines on the management of chronic lbp generally recommend the use of conservative treatments, pharmacological agents and/or invasive treatments. non-steroidal anti-inflammatory drugs (nsaids) are commonly used in pharmacologic therapy, while conservative treatments such as supervised exercise therapy and cognitive behavioural therapy are other possible therapeutic options. if necessary, more invasive treatments including epidural corticosteroids, intra-articular steroid injections and spinal cord stimulation may be considered. with the advances in neuromodulation in recent decades, spinal cord stimulation (scs) has become a well-established therapeutic modality for the treatment of chronic pain. through the delivery of electrical stimulation to the dorsal column of the spinal cord, scs modulates the pain signals and replaces the pain sensation with tingling paraesthesia for pain relief. evidence-based guidelines published by the neuromodulation appropriateness consensus committee (nacc) of the international neuromodulation society recommend the use of scs for a variety of chronic pain conditions, which include failed back surgery syndrome (fbss), complex regional pain syndrome (crps), upper extremity neuropathic pain syndrome, chronic refractory angina and ischemic peripheral neuropathic pain. yet the effectiveness of scs on chronic non-cancer pain management is still unknown in hong kong.

Eligibility criteria:
inclusion criteria: * all patients underwent scs for chronic non-cancer pain management between 2014 to 2021 in queen mary hospital exclusion criteria: * missing of essential data
evaluation of knowledge- attitude- practice (kap) of intern dentists in emergency management of traumatic dental injuries in permanent anterior teeth

Conditions: Traumatized Permanent Anterior Teeth

Summary: this study aims to evaluate knowledge, attitude and practice of intern dentists in emergency management of traumatic dental injuries in permanent anterior teeth in children aged from 6 to 12 years old. a questionnaire survey will be designed to evaluate knowledge - attitude - and practice (kap) of intern dentists who met the eligibility criteria.


Eligibility criteria:
inclusion criteria: * intern dentists attending their internship in faculty of dentistry- cairo university, other private university (modern science and arts university- msa). * the intern dentists who agree to participate. * intern dentists who did not attend pediatric dentistry round, endodontic round, emergency round and surgery round at cairo university. * intern dentists irrespective of age and sex.

Keywords: dental trauma emergency management tooth avulsion knowledge practice traumatic injuries attitude
genetic collection protocol

Conditions: Liver Diseases

Summary: this study involves the one-time collection of whole blood or saliva samples for the extraction and storage of dna for use in ongoing and future children studies.

the purpose of this study is to establish a mechanism to collect a genetic biosample from the participants and their biological parents previously enrolled into clinical research under children-supported protocols (probe, basic, logic, and mitohep). the samples will be linked to the data previously collected on the participant. samples will be stored in the national institute of diabetes and digestive and kidney diseases (niddk) specimen repository and will be used in ongoing and future network and ancillary studies of children to further address the pathophysiology and outcomes of these liver diseases.

Eligibility criteria:
inclusion criteria: * for child participants 1. previous enrollment in probe, basic, logic, or mitohep 2. exited from one of the aforementioned studies. 3. consent for dna sample collection obtained during enrollment during enrollment to one of the aforementioned studies but sample not previously collected. 4. still followed at the clinical site. * for biological parent participants 1. biological parents of previously consented child participant without collection of a parental dna biospecimen. 2. child still followed at the clinical site. exclusion criteria: * for child participants 1. participant is deceased 2. participant exited from prior study due to violating eligibility criteria 3. participant cannot be contacted * for biological parent participants 1. non-biological parent 2. child dna was not previously collected and will not be collected in this study
a follow-up study on total endoscopic thyroidectomy bilateral areola approach

Conditions: Quality of Life

Summary: endoscopic thyroidectomy bilateral areola approach (etbaa) is one of the most widely applied approach in china, meanwhile its safety and effectiveness has been broadly discussed since being introduced. however, these studies are generally with small sample size and short follow-up duration. the lack of long-term follow-up on oncological outcomes makes it inaccurate to evaluate the effectiveness of etbaa versus ot. thus, in this study, we evaluated long-term qol and outcomes of patients with ptc underwent thyroidectomy via etbaa versus ot.


Eligibility criteria:
inclusion criteria: * 1) female patients under 55 years old; 2) no lateral cervical lymph node or distant metastasis were detected before the operation; 3) postoperative pathology confirmed the diagnosis of papillary thyroid carcinoma. exclusion criteria: * 1) previous history of thyroid surgery; 2) lateral cervical lymph node dissection in the operation; 3) past or current history of underlying diseases including hyperthyroidism, hypertension, diabetes, coagulation dysfunction.
bronx mbct-migraine

Conditions: Migraine

Summary: this randomized clinical trial aims to examine the effect of a standardized 8-week course of mindfulness based cognitive therapy for migraine on migraine-related disability in people with migraine.


Eligibility criteria:
inclusion criteria: * ichd-3 beta headache diagnosis of migraine, * self-reported and diary-confirmed 4-20 headache days per month * aged 18-65 * ability to read english * capacity to consent. exclusion criteria: * no ichd-3 beta headache diagnosis of migraine * fewer than 4 or greater than 20 headache days per month * under 18 or over 65 * inability to read english * lacking the capacity to consent * utilization of new preventative pain treatments within four weeks of the baseline assessment, or a plan to utilize new preventive pain medications during the duration of the study * severe psychiatric illness that would interfere with participation in the treatment

Keywords: mindfulness mbct cognitive therapy disability
rectovaginal fistula in post-radiotherapy advanced cervical cancer patients

Conditions: Locally Advanced Cervical Cancer

Summary: to investigate the associated risk factors of rectovaginal fistula

to investigate the associated risk factors of rectovaginal fistula in cervical caner patients after radiotherapy

Eligibility criteria:
inclusion criteria: rectovaginal fistula cervical cancer exclusion criteria: nil
impact of confinement and preventive measures in period of sars-cov2 infection on clinical features, diagnostic and therapeutic management and prognosis of patients with lung cancer

Conditions: COVID; SARS-CoV 2; Lung Cancer

Summary: the unexpected onset of sars-cov2 infection modified our practices, especially in routine medicine. in order to reverse the epidemic curve of severe cases and slow the spread of the infection, confinement was generalized in france from march 13, 2020.these restrictive measures were imposed on anyone with symptoms compatible with the infection, with the exception of dyspnea and other criteria of severity. march 12, 2020 is the pivotal date when the management of covid came to interfere with medical and healthcare organizations. from this date, it is likely that some imaging or endoscopic exams have been de-scheduled for symptoms that are sometimes wrongly judged to be non-urgent and have seen their numbers drop dramatically.otherwise, concerning lung cancer, preventive measures have been extremely strengthened. for instance, it is recommended to delay surgeries for localized tumors, to relieve or remove some chemotherapy or to delete radiotherapy sessions deemed non-essential. however, symptoms that may initially be attributed to viral infection, such as cough, fever, fatigue, or chest pain may be clinical indicators of early-stage lung cancer. in addition, lung cancer is likely to make the patient more susceptible to pneumopathy, due to a weakened of immune response to viruses and bacteria. consequently, as necessary as the restriction measures are, a risk of slowing down in the management of the lung cancer pathology exists. the cbp-covid study intends to assess consequences of restrictive measures linked to the sars-cov2 epidemic, by comparing clinical characteristics at diagnosis, treatment times and treatments, regarding to 2 distinct time periods identical to the calendar, but one in 2019, the other in 2020.


Eligibility criteria:
inclusion criteria: * patient newly diagnosed with a lung cancer based on histological or cytological criteria. * patient followed by investigating site participating in the study. * patient informed verbally and by an information document specifying the interest of the study and having given his oral agreement for the participation for the prospective part of the study. exclusion criteria: * patient investigated and / or monitored in a site not involved in the study. * patient with lung cancer of incidental finding during hospitalization for another reason. * patient with recurrence of a previoulsy known lung cancer. * patient included in a clinical research trial.

Keywords: diagnostic management therapeutic management
multicentric evaluation of covid-19 impact on cancer patients' diagnostic and management: set-up of indicators

Conditions: Hepatocellular Carcinoma; Peritoneal Carcinoma

Summary: the covid-19 pandemic has deeply and globally impacted usual procedures and patients management in cancer centers. the aim of this study is to set-up and collect indicators to follow-up the activities of different cancer pathologies before and during the pandemic. patients loss' of chance will be analysed in term of diagnosis and access to care (surgery, antineoplastic treatments). data collection will focus on the analysis of 2 specific pathologies for french patients in the "auvergne-rhône alpes" area: peritoneal carcinosis and hepatocellular carcinoma.


Eligibility criteria:
inclusion criteria: * patients hospitalized in france for peritoneal carcinosis or hepatocellular carcinoma between 2017 and 2020. exclusion criteria: * patients who did not allow the reuse of their medical data for research

Keywords: covid-19 cancer health care quality indicators hepatocellular carcinoma peritoneal carcinosis
early oral feeding after total gastrectomy for cancer

Conditions: Adenocarcinoma of the Stomach

Summary: the aim of this study is to evaluate the possibility of shortening postoperative hospital stay after gastrectomy by early oral feeding as a component of an enhanced recovery protocol (eras).


Eligibility criteria:
inclusion criteria: * total gastrectomy for cancer * age 18 - 80 years * informed consent exclusion criteria: * numerous hepatic and peritoneal metastases * extended resections (pancreas, colon) * preoperative malnutrition requiring total parenteral nutrition * emergency surgery

Keywords: gastrectomy gastric cancer oral feeding complications
mesenchymal stem cells in knee cartilage injuries

Conditions: Articular Cartilage Disorder of Knee; Osteoarthritis, Knee

Summary: induction of autologous repair chondrogenesis to regenerate injured articular cartilage using bone marrow mesenchymal stem cells (mscs) after in vitro expansion under restricted culturing conditions.

fourteen patients from both genders, age range 40-68, will be enrolled according to strict inclusion and exclusion criteria, divided into two equal groups based upon receiving autologous mscs alone, or mscs supported by platelet lysate through percutaneous injection. the patients are followed by clinical assessment, laboratory investigations as well as magnetic resonance imaging (mri) of the injected knee. the investigators hypothesize that the two groups will give satisfactory clinical outcomes, but the investigators are looking forward to assessing the best product that will activate chondrogenesis and heal cartilaginous injury.

Eligibility criteria:
inclusion criteria: * mri must show moderate/severe articular injury * serum collagen ii must be above the normal value. * lesion site: femoral and tibial condyles or patella * admission of steroid , nsaid, pain killers must be stopped before 1 month exclusion criteria: * lesion size * pt and ptt not within normal value * complete blood count ( hb, pcv, and rbc) not within the normal value * hiv and hepatitis antigens (b and c) detection

Keywords: bone marrow derived mesenchymal stem cells knee articular cartilage injury chondrogenesis orthopedics
acute effect of chromatic environment during chemotherapy

Conditions: Breast Cancer

Summary: the primary objective is to examine the acute effect of color, room orientation (affecting amount of luminosity) on perceived health status and stress levels in oncologic patients during chemotherapy sessions at outpatient clinic. the secondary objectives will be to study the effect on vital signs (body temperature, heart rate, systolic blood pressure). patients will be allocated into four conditions (group a: cold north, group b: cold south c: warm north d: warm south) for each session. for the next session, patients will be assigned a new condition. assignment of sequences will be randomized for each patient. 20 patients will be randomly assigned to one of the four groups, after having signed the free and informed consent form and agreed to participate in the project, will respond to the evaluation form and will be submitted to physical examination. patients will be treated per standard of care.


Eligibility criteria:
inclusion criteria: * age 18-89 years * diagnosed with breast cancer that required chemotherapy * followed in outpatient clinic exclusion criteria: * diagnosed color blindness * undergoing treatment with antidepressants

Keywords: chemotherapy vital signs stress health status healing environment
proof of concept study of an oral orthotic to reduce tic severity in chronic tic disorder and tourette syndrome

Conditions: Tourette Syndrome; Chronic Tic Disorder

Summary: the purpose of this study is to assess the feasibility of a trial on an oral orthotic for reducing tic severity in children ages 7-25 years with tourette syndrome (ts) or chronic tic disorder (ctd).

the study is a 2 group, 2 week randomized controlled feasibility trial of an active vs sham oral orthotic to reduce tic severity in children and adolescents ages 7-25 years. responders to acute phase treatment will be followed for 10 additional week (12 weeks total) to assess intervention durability, safety and acceptability. non-responders to the sham orthotic will be provided active treatment at the end of the 2 week acute phase. we aim to assess and enroll 24 participants; twelve participants will receive an orthotic adjusted to the appropriate therapeutic height, and twelve participants will receive an identical sham orthotic, but not adjusted to the recommended height for the given participant.

Eligibility criteria:
inclusion criteria: * age 7-25 inclusive. * presence of motor and/or vocal tics for at least 12 months. * tics are of at least moderate clinical severity as evidenced by a yale global tic severity score of 14 or higher for motor or vocal tics only and 22 or higher for tourette syndrome and present during the baseline assessment. * iq estimate of 70 or higher * comorbid disorder (e.g., adhd, ocd, odd) will be allowed provided that the tic symptoms are of primary concern to parents and comorbid symptoms are not of sufficient severity to require immediate treatment other than that provided by the current study. * pre-existing stable medication (see protocol for details), tic or otherwise, will also be allowed provided the family agrees to refrain from med changes over the course of the acute phase of the study * sufficient command of the english language to participate in informed consent and assessment procedures. * agree for videotaping of study procedures * clearance by treating dentist: certification of good dental health provided by the subjects current dentist prior to enrollment in the study exclusion criteria: * major psychiatric disorder at screening that would preclude full participation in study procedures including psychosis, mania, depression, untreated combined type adhd, autism and pervasive developmental disorders. * medication changes are planned during the acute and follow-up phase of treatment. * other dental health problems that might interfere with the assessment, installation, or wearing of orthotic device. * does not consent to being videotaped

Keywords: tourette's tic disorder dental appliance oral orthotic mouthguard
influence of neck design on peri-implant hard and soft tissues

Conditions: Bone Resorption; Soft Tissue Bleeding

Summary: the goal of this clinical trial is to test two different implant neck designs in 36 patients. the main question\[s\] it aims to answer are: * do triangular neck designed implants placed immediately after dental extraction have the same influence on peri-implant hard and soft tissues than regular neck designed implants at one year? * do triangular neck designed implants placed immediately after dental extraction have the same influence on peri-implant hard and soft tissues than regular neck designed implants at three years? participants that present an unrepairable tooth on the anterior upper maxilla will be asked to take a cbct scan in order to verify the presence of the buccal bone. once this is verified the patients will enter in the study and the day of the surgery they will be assigned to either control or test group. * control group: c1 round-neck implant * test groups: v3 triangular-implant neck researchers will compare test and control groups to see if they have the same effects on hard and soft tissues at 4 months, 1 year and 3 years.

immediate implant placement is considered to be a technique-sensitive protocol with a variety of potential risks. the interface area between the neck of the implant and the abutment is critical; it can affect the treatment outcome, particularly mar-ginal bone loss (mbl) and soft tissue behavior. traditionally, the implant neck is circu-lar in shape; however, a new triangular neck design has recently been introduced on the market, though advanced indications of this innovative design are still lacking. the objective of this randomized clinical trial was to compare the clinical and radiographic outcomes obtained after immediate placement of implants and temporization of two different neck geometries: a traditional round neck (rn) and an innovative neck with a triangular shape (tn).

Eligibility criteria:
inclusion criteria: * healthy non-smokers or light smokers (\< 10 cigarettes/day) * adults (\> 18 years of age), * need for single tooth extraction of a maxillary incisor, canine or premolar * adequate oral hygiene * ability to follow instructions and attend the required appointments * presence of a length of at least 3 mm of buccal bone measuring ≥ 0.5 mm in thickness, apical to the extraction socket * stable and intact socket walls exclusion criteria: * patients with acute infections in the area of interest * individuals with large occlusal discrepancies and/or occlusal overload para-functions * smokers of more than 10 cigarettes/day * patients with any medical condition or medication contraindicating dental implant treatment

Keywords: dental implants implant neck design immediate implants immediate provisionalization buccal bone thickness