Kornimate/medical-research-clean huggingface dataset:
a double-blind study evaluating ipi-504 and docetaxel in patients with non-small cell lung cancer

Conditions: Non Small Cell Lung Cancer

Summary: the purpose of this study is to compare the impact of ipi-504 in combination with docetaxel to placebo in combination with docetaxel on life expectancy in patients with non small cell lung cancer (nsclc). docetaxel is an approved chemotherapy for nsclc. an additional goal of the study is to determine the effect of ipi-504, in combination with docetaxel, verses placebo in, combination with docetaxel, on the growth of cancer

this is a phase 2, double-blind, randomized, placebo-controlled study in patients with previously treated, locally advanced or metastatic stage iiib or iv nsclc designed to compare ipi-504 plus docetaxel versus placebo plus docetaxel. all patients will have at least a 15 pack year smoking history. tumor samples will be assessed by a central pathology reviewer to confirm pathology that is documented at baseline; this review need not occur in advance of randomization.

Eligibility criteria:
inclusion criteria: * patients must be ≥18 years of age * voluntarily signed an informed consent * confirmed nsclc and stage iiib or iv disease. * at least a ≥15 pack year smoking history and must have been an active smoker within 20 years of diagnosis. * must have archival nsclc tissue available to provide for analysis or have a lesion that is accessible for biopsy * must have experienced disease progression during or after receiving at least 1 prior platinum-containing chemotherapy regimen. * must have received no more than 2 prior chemotherapy regimens * measurable disease by recist 1.1 criteria. * ecog performance status of 0 or 1 (refer to scale in appendix 1). * women of child-bearing potential (wcbp), all sexually active male patients, and partners of patients must agree to use adequate methods of birth control. exclusion criteria: * prior docetaxel, ipi-504 or other hsp90 inhibitor treatment * known hypersensitivity to drugs formulated with polysorbate-80. * not recovered from any toxicities related to prior treatment * use of a medication or food that is a clinically relevant cyp3a inhibitor or inducer * inadequate hematologic function * inadequate hepatic function * inadequate renal function * symptomatic keratitis or keratoconjunctivitis. * uncontrolled systemic fungal, bacterial, viral or other infection * patients with clinically active brain metastases * patients with clinically stable brain metastases (previously treated or untreated) are eligible. * sinus bradycardia (resting heart rate \<50 bpm). * significant cardiac disease * previous or current malignancies at other sites within the last 2 years * prior hepatic resections or hepatic-directed therapy * known hiv-positive patients receiving combination antiretroviral therapy. * women who are pregnant or lactating.

Keywords: lung neoplasms large cell carcinoma squamous cell carcinoma
serum amyloid a in women with unexplained infertility

Conditions: Infertility

Summary: high follicular fluid amyloid a level is associated with reduced pregnancy rate. the aim of this study was to find an association between serum level of amyloid a and unexplained infertility.


Eligibility criteria:
inclusion criteria: 1. women with unexplained infertility (unprotected, regular intercourse for at least 2 years). 2. nulligravida ,regular mensturation. 3. age less than 40 years . 4. normal parameters (in the study group): * hormonal profile (day 2 fsh,lh), midluteal phase progesterone, prolactin, tsh * transvaginal ultrasound * hysterosalpingography * detailed semen analysis exclusion criteria: 1. age above 40 2. smoking females 3. obesity (bmi\>30) 4. women with any systemic or medical diseases leads to elevation of saa as: 1. systemic lupus erythematosis 2. rheumatoid arthritis 3. sarcoidosis 4. diabetes mellitus 5. using hormonal contraception (for control group)
mri analysis and degenerative spine

Conditions: Spine Disease

Summary: analysis of mri advanced techniques in degenerative spinal disease. the main questions it aims to answer are: * can we assess microstructural integrity of compressed nerve roots in degenerative spinal disease * what are the image biomarkers affected by disease * how they evolve with disease progression and treatment


Eligibility criteria:
inclusion criteria: * age between 50 and 85 years * diagnosis of spinal disease by clinical and imagiological criteria * more than 3 months duration of disease * ability to give consent * fluent portuguese speaker exclusion criteria: * previous spine surgery * spinal instability * neurological disease that might interfere with walking * known orthopedic conditions that causes significant gait impairment * dementia or development disorder with cognitive impairment * inability to give consent
first rib resection versus avulsion for thoracic outlet syndrome

Conditions: Thoracic Outlet Syndrome

Summary: the management of thoracic outlet syndrome can be either surgical or nonsurgical. fewer than 20% of patients experience benefits from nonsurgical treatments. regarding the surgical approach, there's considerable debate about whether to resect the first rib or if a scalenectomy alone suffices. recently, many experts have concurred on the resection of the first rib. based on our observations, avulsion of the first rib results in improved outcomes and reduced post-operative pain compared to simple resection. thus, this study aims to compare the outcomes of first rib resection versus its avulsion in patients with thoracic outlet syndrome.


Eligibility criteria:
inclusion criteria: any patient diagnosed as a case of neurogenic thoracic outlet syndrome - exclusion criteria: patients with other types of thoracic outlet syndrome (vascular tos) -
hiv counseling intervention for methadone-maintained patients - 2

Conditions: Opioid-Related Disorders

Summary: the purpose of this study is to evaluate hiv counseling intervention for methadone-maintained patients.

the purpose of this proposal is to evaluate, in methadone-maintained patients the association between an adhd diagnosis and high-risk hiv/hepatitis behavior. in addition, the investigators would like to determine whether a new manually-guided hiv intervention; rise: reduce high risk intravenous drug use and unsafe sexual encounters is superior to standard hiv/hepatitis psycho-education.

Eligibility criteria:
inclusion criteria: * must meet dsm-iv criteria for opiate dependence and currently in methadone maintenance treatment * able to give informed consent and capable of complying with study procedures * women who are of childbearing age and/or pregnant may be included * individuals who are hiv-positive or have acquired immunodeficiency syndrome may be included * patients who demonstrate moderate to high hiv risk behaviors will be included * patients with low to no hiv risk behaviors will be excluded * patients receiving a stable dose of methadone for three weeks will be included exclusion criteria: * currently meets dsm-iv criteria for current axis i psychiatric disorders (other than adhd or substance abuse) which requires medical intervention, i.e., active suicide ideation, active psychosis, anxiety disorders, depression requiring hospitalization * patients who have exhibited suicidal or homicidal behavior within the past two years * hiv positive patients must have knowledge of their status for a minimum of three weeks

Keywords: hiv methadone maintenance
fatty liver disease in obese children

Conditions: Obesity; Nonalcoholic Fatty Liver Disease; Cardiovascular Disease

Summary: although weight reduction through physical activity-based interventions is the mainstay therapy for nonalcoholic fatty liver disease (nafld), its maintenance is difficult and typically unsuccessful. this affirms the extreme need for alternate and/or adjunct therapies. although convincing data from animal studies and a few adult human studies on the benefits of a natural product, n-acetyl cysteine (nac), in a variety of liver conditions including nafld have emerged, studies in children are scarce. therefore, the aim of the study is to test the use nac as an innovative approach to attenuate the progression of nafd in obese children with biopsy proven nash. the central hypothesis is that nac supplementation will reduce liver fat and liver enzymes and ameliorate risk factors of cardiometabolic disease in children with nafld.

physical activity (pa)-induced weight reduction, the suggested therapy for noalcoholic liver disease (nafld), is difficult and its maintenance is typically unsuccessful in children, affirming the acute need for alternative/adjunct therapies. although few promising approaches have been reported, the benefits are incongruent and mostly marginal. n-acetyl cysteine (nac), a derivative of the natural amino acid, cysteine, appears to be promising as an adjunct therapy to pa. animal and a few adult human studies suggest nac-induced attenuation of liver abnormalities, oxidative stress, insulin resistance and inflammation. the primary aim of the proposal is to determine in obese children with biopsy proven nash and elevated liver enzymes the effect of nac at two different doses on liver fat using magnetic resonance imaging (mri), liver enzymes and risk factors of cardiometabolic disease. we hypothesize that nac will produce beneficial effect on these parameters.

Eligibility criteria:
inclusion criteria: * age 7 years and older * nash confirmed in a previous biopsy * hbaic \<6.4% * alt \> 60 u/l or 1.5 times the upper limit of normal exclusion criteria: * chronic liver disease including alpha-1-antitrypsin deficiency, wilson's disease, autoimmune and viral hepatitis * medications such as adrenergic β-blockers, steroids and other drugs known to interfere with the measurement of liver enzymes and risk factors for cardiovascular disease * heart disease, chronic renal disease, adrenal, hepatic or thyroid dysfunction; active malignancy; and anemia * history of prior treatment with nac * evidence of hypersensitivity/allergy to nac * alcoholism or drug abuse and smoking * inter-current illness over 7 days before the study \& surgery in the past 3 mo.

Keywords: fatty liver obesity children oxidative stress antioxidants
myo-inositol versus metformin administration in post-menopausal women with metabolic syndrome

Conditions: Metabolic Syndrome

Summary: myo-inositol is classified as a member of the vitamin b complex. it is a constituent of living cells and is widespread in many food. it is involved in a number of biological processes, including insulin signal transduction, resulting in modulating insulin sensitivity. one hundred post-menopausal women from 50 to 60 years old, affected by metabolic syndrome (criteria are described in nih atp iii) will be randomized into two groups: 50 treated with myo-inositol 2 g twice per day and fifty treated with metformin for six months. metformin is the drug usually used in diabetic and pre-diabetic conditions, as metabolic syndrome. the investigators hypothesize that the administration of myo-inositol would improve the insulin-receptor activity in these women, reducing insulin resistance as well as metformin. outcome measure: homa-ir, blood pressure level, serum triglycerides and cholesterol, bmi and waist circumference


Eligibility criteria:
inclusion criteria: * post-menopausal outpatients affected by the metabolic syndrome, whose criteria are described in nih atp iii, 2001. exclusion criteria: * post-menopausal outpatients without metabolic syndrome * assumption of hypocholesterolemic or other insulin sensitizing drugs

Keywords: insulin resistance body mass index myo-inositol serum triglycerides and cholesterol blood pressure metformin
study of non-surgical treatment versus observation in asian children with intermittent exotropia

Conditions: Intermittent Exotropia

Summary: non-surgical treatment (ie. patching or fusion exercises) of intermittent exotropia may help in increasing control of strabismus


Eligibility criteria:
inclusion criteria: 1. age 3 to 12 years (inclusive) 2. ixt for distance or constant ixt for distance and either ixt or exophoria for near 3. ixt size of \> 10pd 4. visual acuity in worse eye of at least 0.3 logmar (snellen 6/12) 5. visual acuity of no greater than 2 lines between eyes 6. parents or guardian willing to accept randomization, and to continue with observation or treatment for at least 6-12 months, unless deterioration of strabismus or fall in best corrected visual acuity of worse than 0.3logmar (snellen 6/12) in either eye 7. investigator willing to observe ixt untreated for at least 1 year exclusion criteria: 1. previous non-surgical treatment for ixt, or patch treatment for amblyopia within the last year 2. prior strabismus, intraocular or refractive surgery or botulinium injection 3. surgery planned within the next year 4. prematurity (birth weight \< 1500g, gestational age \< 34 weeks), systemic illness (eg. cerebral palsy), syndrome (including craniosynostosis) or learning disability 5. any ocular abnormality (cornea, lens or central retina); nystagmus or conditions that limit eye movements.
intravenous administration of metoprolol versus biatrial pacing in the prevention of atrial fibrillation after cardiac surgery

Conditions: Atrial Fibrillation; Biatrial Pacing; Metoprolol

Summary: the aim of the study is to compare the effectiviness of biatrial pacing versus intravenous administration of metoprolol in the prevention of atrial fibrillation after cardiac surgery


Eligibility criteria:
inclusion criteria: * elective cabg and aortic valve cardiac patients, * previous use of beta blocker exclusion criteria: * previous episodes of atrial fibrillation or flutter, * ii or ii degree atrioventricular block, uncontrolled heart failure * sick sinus syndrome

Keywords: prevention
dermacyd teen care tangerina mix - compatibility

Conditions: Hygiene

Summary: the purpose of this study is to demonstrate the absence of irritation potential (primary dermal irritability and cumulated dermal irritability) and allergy (sensibilization) of the product dermacyd teen care tangerina mix.


Eligibility criteria:
inclusion criteria: * phototype skin i,ii, iii e iv * integral skin test in the region exclusion criteria: * lactation or gestation * use of anti-inflammatory and/or immuno-supression drugs 1 month before the study * personal history of atopy * history of sensitivity or irritation for topic products * active cutaneous disease * use of new drugs or cosmetics during the study the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
vaginal microbiome and hpv pre-malignant and cervical dysplasia

Conditions: Human Papilloma Virus; Vaginal Flora Imbalance; Cancer Cervix Uterus; Cervical Dysplasia

Summary: in this study, the investigators will prospectively collect, analyze and integrate information regarding vaginal microbiome composition and hpv presence in women with cervical pathologies (high-grade cin and cc) and controls, to construct a large dataset from patients with pre-cancerous cervical lesions and healthy women, to evaluate the personalized contribution of the vaginal microbiome to the cin-cc sequence.

infection with high-risk human papillomavirus (hpv) genotypes constitutes a well-recognized risk factor for cervical-carcinoma (cc). high-risk hpv features 10-15% persistence rate, consequently driving precancerous cervical-intraepithelial-neoplasia (cin) and subsequent progression to cc. multiple factors are believed to play permissive roles in the progression of cin/cc , yet a molecular mechanism driving carcinogenesis across the cin-cc continuum following persistent hpv infection remains elusive. the vaginal microbiome may play a role in the development of cin-cc carcinogenesis, by modulation of host-immune-response and alteration of cervical microenvironment to become tumor-permissive. while suggested vaginal microbiome contributions include induction of altered epithelial cell adhesion and downregulation of dna damage responses, no clear mechanism has been proven to date. the loss of lactobacillus genus dominancy, and the switch to dysbiotic, high-diversity, high-ph, bacterial vaginosis (bv) is thought to play a key-role in hpv infection, persistence and carcinogenesis. the investigators hypothesize that specific vaginal microorganisms may promote hpv persistence, chronic inflammation and progression through the cin-cc sequence, and the elimination of harmful bacteria or supplementation of beneficial microbes, could possibly reverse hpv persistency and inhibit cin-cc progression. the current study consists of recruitment of a human cohort of healthy, cin and cc patients including vaginal samples and comprehensive metadata collection. the investigators plan to conduct an in-depth characterization of vaginal microbiome to identify associations with hpv, cin and cc.

Eligibility criteria:
inclusion criteria: * age 25-70 * attended the clinic for a pap smear or colposcopy exclusion criteria: * patient does not approve sample collection * usage of antibiotics in the month prior to clinic visit * usage of any vaginal preparation or medication in the week prior to sample collection (anti-fungal, spermicides, lubricant etc.) * menstruation * pregnancy
clinical decision support to reduce catheter associated urinary tract infections

Conditions: Health Care Associated Infection; Catheter-associated Urinary Tract Infection

Summary: the goal of this randomized controlled trial is to compare the effects of a clinical decision support tool consisting of a 48-hour stop order for indwelling urinary catheters versus no clinical decision support in hospitalized patients with indwelling urinary catheters. the main questions it aims to answer are: - does the presence of an automated stop order integrated as part of a clinical decision support tool reduce dwell time of urinary catheters and the rate of catheter associated urinary tract infections? participants who have indwelling urinary catheters ordered will be randomized to either have these orders automatically expire after 48 hours unless an action is taken or have orders without expiration. researchers will compare the urinary catheter dwell time and the rate of catheter associated urinary tract infections between the two groups.


Eligibility criteria:
inclusion criteria: * admitted to hospital * at least 18 years old * has order placed for indwelling urinary catheter exclusion criteria: * indication for urinary catheter labeled as either "chronic" or "placed by urology"
effect of slope time in pcv mode on mechanical power calculation and oxygenation in covid-19 ards patients.

Conditions: COVID-19 Pneumonia; COVID-19 Acute Respiratory Distress Syndrome

Summary: the investigators are planning to investigate the effect of each 5% slope time change on mechanical power and spo2 of the patients with covid 19 ards diagnosis which are on mechanical ventilation pcv mode support.

in this study, with inspiration/expiration 1:2 and 1:1 time ratios in pressure controlled ventilation mode with different slope times mechanical power will be calculated in covid ards patients. in this way, the effect of every 5% slope time change in pcv on mechanical power and spo2 will be investigated.

Eligibility criteria:
inclusion criteria: * adult patients with covid-19 acute respiratory distress syndrome (ards) diagnosis * intubated covid-19 ards patients * covid-19 ards patients on mechanical ventilator support exclusion criteria: * heart failure disease * chronic obstructive pulmonary disease (copd) * hemodynamically unstable patients * pregnancy

Keywords: tslope pressure controlled ventilation mechanical ventilation
mdr surelock all-suture anchor

Conditions: Shoulder Pain; Shoulder Injuries; Shoulder Disease; Shoulder Pain Chronic; Shoulder Syndrome; Labral Tear, Glenoid

Summary: to report the outcomes of a series of patients with recurrent anterior and/or posterior shoulder instability who underwent surgical repair of the affected labrum using the surelock all-suture anchor.

patient-reported outcomes data have been collected among patients undergoing shoulder labrum repair with surelock all-suture anchors from january 2014 to june 30, 2020. these patients have completed clinical and quality-of-life outcome instruments pre-operatively, and have been stored securely in the oberd database. pre-op scores will be compared to post-op scores and analyzed using a one-way anova test with a post-hoc scheffe procedure. patient identifying information will be removed and de-identified codes will be used. any new prospective data gathered prospectively for the purposes of this study will be entered and stored securely as above. data collection forms will consist of the following patient-reported outcome surveys: wosi index, ases shoulder score, and the sf-12.

Eligibility criteria:
inclusion criteria: * 14 to 45 years of age * surgery performed between 1/1/14-12/31/2021 * recurrent shoulder instability resulting from an isolated anterior and/or posterior glenoid labral tear * completed pre-operative data (wosi, ases, sf-12) exclusion criteria: * diagnosis of concomitant slap tear * diagnosis of concomitant full-thickness rotator cuff tear * greater than 10% loss of glenoid bone * greater than 25% humeral head defect * prior surgical intervention for the treatment of shoulder instability (in either the affected shoulder or the contralateral shoulder) * adults unable to consent * individuals who are not yet adults (infants, children, teenagers) * pregnant women * prisoners
progression of stereopsis recovery in strabismic patients: a one-month and three-month post-surgery evaluation

Conditions: Strabismic Amblyopia, Bilateral

Summary: this prospective longitudinal observational study aims to assess stereopsis recovery in strabismic patients at one month and three months post-corrective surgery. the study will be conducted at mayo hospital, lahore, and sajjad eye center, burewala, with a sample size of 34 using a purposive sampling technique. eligible participants include patients aged ≥5 years undergoing strabismus surgery for esotropia, exotropia, or vertical deviations, with best-corrected visual acuity (bcva) of 6/12 in both eyes. patients with previous strabismus surgery, amblyopia, neurological conditions, or sensory strabismus will be excluded.

baseline assessments include visual acuity (snellen chart), ocular alignment (cover-uncover and prism cover tests), and stereopsis (titmus fly test). the same tests will be repeated one month and three months post-surgery to evaluate changes. the study aims to determine whether strabismus surgery enhances binocular function and stereopsis, helping guide future treatment strategies. data will be analyzed using paired t-tests to assess differences over time.

Eligibility criteria:
inclusion criteria: * patients (≥5 years and adults) undergoing strabismus surgery for: esotropia, exotropia, vertical deviations (hypertropia or hypotropia) * best corrected visual acuity (bcva) of 6/12 in both eyes * willingness to attend follow-up visits at 1 month and 3 months post-surgery.8 exclusion criteria: * history of previous strabismus surgery * amblyopia * neurological and systemic conditions affecting vision * uncontrolled nystagmus and sensory strabismus * patients unable to complete stereopsis testing due to cognitive or physical limit