Kornimate/medical-research-clean huggingface dataset:
clinical success of onlays fabricated with different types of resin

Conditions: Endodontically-Treated Teeth

Summary: additive manufacturing, also referred to as "3d printing" or "rapid prototyping," is defined as the process of joining materials layer by layer to create an object based on 3d model data. in this method, a digital data set is first created on a computer (computer-aided design, cad) and then transferred to a 3d printer. the designed object is produced by printing it in successive layers. in contrast, in subtractive manufacturing, restorations are produced by milling homogeneous blocks based on computer-designed models. compared to subtractive manufacturing technology, additive manufacturing allows for the production of more complex, detailed, and larger structures with much less material waste and without excessive use of force. it is thought that additive manufacturing has the potential to overcome the disadvantages of subtractive manufacturing. over the past decade, global sales of industrial and personal 3d printers, materials, and services have increased by more than 33% annually. due to its success in the production of surgical guides, temporary and permanent restorations, crowns and bridges, occlusal splints, frameworks, and orthodontic appliances, this technology has attracted significant interest in the field of dentistry. although additive manufacturing has started to be used as an alternative to subtractive manufacturing in many applications, there is still a lack of information regarding the chemical composition, mechanical, and physical properties of printable resins. moreover, clinical data on the use of these resins in permanent restorations are quite limited. therefore, the aim of this study is to clinically evaluate and monitor for one year the performance of onlay restorations fabricated with three different resins of varying compositions in endodontically treated teeth.


Eligibility criteria:
inclusion criteria: * molar teeth that have undergone root canal treatment * teeth with proximal defects located above the gingival margin * defects limited to the occlusal surface and a single adjacent surface * presence of an occlusal defect extending over one-third of the distance between the fissure and the cusp tip and involving one or more cusps * presence of an opposing tooth or a fixed prosthetic restoration against the tooth to be restored * presence of adjacent teeth next to the tooth to be restored exclusion criteria: * fractured or cracked teeth * patients with temporomandibular joint disorders * patients with bruxism (teeth grinding) * molar teeth without an opposing tooth or fixed prosthetic restoration * molar teeth without adjacent teeth * vital teeth * patients with a history of allergy to the components of the resins

Keywords: onlay endodontically -reated teeth indirect restoration additively manufactured hybrid resin
use of a freeze-dried amniotic membrane post crosslinking in subjects with progressive keratoconus

Conditions: Progressive Keratoconus

Summary: crosslinking is a therapeutic technique used to increase the rigidity of the cornea in order to slow or stop progression of keratoconus. the main complication of the treatment of keratoconus by crosslinking is postoperative pain due to the removal of the corneal epithelium. currently, the management of pain is done through the administration of artificial tears and paracetamol. the amniotic membrane is a biological tissue used in ophthalmology to treat injuries of the surface of the eye. it has healing and analgesic properties. the objective of this multicenter randomized study is to evaluate the benefit of placing an amniotic membrane on the eye post-crosslinking to reduce pain and promote corneal healing.


Eligibility criteria:
inclusion criteria: * man or woman between 18 and 65 years old. * indication for accelerated conventional crosslinking. * patient with progressive keratoconus (increase in kmax of ≥ 0.5 diopters in 3 to 6 months or ≥ 1 diopter in 3 to 12 months with loss of 10 microns on minimum pachymetry in 3 to 12 month). * patient suffering from keratoconus with a compatible topographic form (kmax ≥ 47.0 diopters (d) and difference inferior-superior of 1.5 d). * patient with a minimum corneal thickness greater than 400 microns. * informed and consenting patient. * patient physically and mentally capable of completing the post-operative pain assessment self-questionnaire. * patient having signed the informed consent of the french ophthalmology society for crosslinking. * patient affiliated to a social security system or beneficiary of such a system. exclusion criteria: * woman without effective means of contraception, pregnant or breastfeeding. * patient who has already benefited from a crosslinking procedure on one of the eyes. * patient with a history of refractive surgery on one of the eyes. * patient with an intracorneal ring segment on one of the eyes. * patient suffering from a serious systemic pathology (autoimmune and/or immunodepressive) * patient with a psychiatric pathology. * patient on long-term analgesics and/or corticosteroids. * indication of crosslinking outside the classic protocol. * patient with central corneal opacity. * patient suffering from a severe dry eye syndrome or a neurotrophic keratitis. * patient with a history of ocular herpes. * patient with a history of ocular varicella-zoster virus infection. * patient with glaucoma. * patient treated with topical cyclosporine in the last 6 months. * patient deprived of liberty by a judicial or administrative decision. * patient subject to a legal protection measure or unable to express their consent.
fluorescence-guided resection of malignant gliomas with 5-aminolevulinic acid

Conditions: Brain Cancer; Brain Tumors; Cancer of Brain; Primary Brain Tumors; Brain Tumor, Primary

Summary: the aim of the study "fluorescence-guided resection of malignant gliomas with 5-aminolevulinic acid (5-ala) vs. conventional resection" is to determine how accurately contrast agent-accumulating tumour can be removed by primary surgery and to assess the clinical usefulness of this method.

malignant gliomas are locally invasive tumors that carry a dismal prognosis despite a combination of surgery, radiotherapy and chemotherapy. cytoreductive surgery is generally considered beneficial but complete resection of contrast enhancing tumor is achieved in less than 20 % of patients, one reason being the difficulty in discerning marginal, enhancing tumor intraoperatively. five-aminolevulinic acid (5-ala) leads to the accumulation of fluorescent porphyrins in malignant gliomas, a phenomenon under exploration for intraoperative identification and resection of these tumors. this study investigated the benefit derived from fluorescent-guided resections using 5-ala on surgical radicality, progression-free survival and morbidity.

Eligibility criteria:
inclusion criteria: * radiological suspicion of a unilocular malignant glioma with distinct ring- or garland-shaped contrast agent-accumulating tumour structures and a core of reduced intensity in the mri (central necroses) with no significant non-staining tumour tissue (exclusion of a secondary malignant glioma). * indication for surgical tumour resection. if radical resection is planned, the location of the contrast agent-accumulating tumour should allow complete resection. * first operation of the tumour, no other tumour-specific pretreatment * karnofsky at least 70 % * patient's written informed consent * age 18-72 years exclusion criteria: * tumour location in the midline, basal ganglia, cerebellum or brain stem * more than one contrast agent-accumulating lesion unrelated to the primary tumour or extracerebral metastases * porphyria, hypersensitivity to porphyrins * renal insufficiency: creatinine \> 2.0 mg/dl * hepatic insufficiency: bilirubin \> 3 mg/dl * quick test \< 60 % * gamma-gt \> 70 u/i * malignancies other than basaliomas * existing or planned pregnancy or lactation, or inadequate contraception * simultaneous participation in another clinical trial or participation in another clinical trial in the 30 days preceding randomisation
a prospective, randomized clinical study on the effects of casein phosphopeptide-amorphous calcium phosphate (cpp-acp) paste on plaque, gingivitis and white spot lesions in orthodontic patients - part 1

Conditions: Early Caries Lesions

Summary: influence of cpp-acp paste on the evolution and appearance of white spot lesions in orthodontic patients after removal of the fixed appliances.


Eligibility criteria:
inclusion criteria: * one or more white spot lesion at the time of removal of fixed appliances exclusion criteria: * white spots already present before start orthodontic treatment
advanced chronic liver disease screening by transient elstography in patients hospitalised in a psychiatric unit

Conditions: Psychiatric Disorder; Psychiatric Hospitalization; Advanced Chronic Liver Disease; Liver Fibrosis

Summary: scares data exists concerning the prevalence of chronic liver diseases in people with psychiatric disorders. there are still many barriers to screening and linkage to care for patients having somatic illness. moreover follow-up of these patients may be difficult because of poor access to care, sometimes marginalization, and insufficient compliance with health programs. the aim of this study is to asses acceptability of of advanced chronic liver disease screening by transient elstography (fibroscan ®) in patients hospitalised in a psychiatric unit.

scares data exists concerning the prevalence of chronic liver diseases in people with psychiatric disorders. there are still many barriers to screening and linkage to care for patients having somatic illness. moreover follow-up of these patients may be difficult because of poor access to care, sometimes marginalization, and insufficient compliance with health programs. transient elastography is a useful tool validated for early diagnosis advanced chronic liver disease.it is non-invasive, fast, and gives immediate results. the aim of this study is to assess acceptability of of advanced chronic liver disease screening by transient elstography (fibroscan ®) in patients hospitalised in psychiatric unit. moreover, we will estimate de prevalence of advanced chronic liver diseases according to specific causes in psychiatry unit we hypothesize that the fact of offering psichiatric patents a non-invasive analysis of hepatic fibrosis will improve the detection of serious liver diseases and linkage to care.

Eligibility criteria:
inclusion criteria * adults ≥18 years * having a psychiatric condition and hospitalized in a psychiatry unit of chu montpellier , france * patients who lack capacity of consent if legal representative consents * involuntary psychiatric hospitalization, if consent is given exclusion criteria * lack of written consent * unable to understand nature and objective of the methodology * pregnant or breast feeding woman * not affiliated with a french social security

Keywords: psychiatric disorders advanced liver disease alcoholic liver diseases viral hepatitis transient elastography (fibroscan ®)
effect of phlebotomy on heartrate in polycythemia patients

Conditions: Polycythemia

Summary: single-centre, observational within-subject design: patients that undergo phlebotomies regularly for polycythemia will be measured continuously by wearables one week before until one week after a phlebotomy, for three phlebotomies.

rationale: little is known about the effect of a hemoglobin-shift on patients, anaemic, non-anaemic or even polycythaemic. it has been established that severe anaemia has deteriorating effects on the patient, which can be (partially) reversed by treatments like transfusion, erythropoietin stimulating agents or iron/vitamin supplements, depending of the etiology of the anaemia. however, the optimal haemoglobin target and threshold for such treatments has yet to be determined. it is therefore necessary to evaluate what the exact effect of various haemoglobin levels, and a shift therein, is on the physiology of patients. only then can the benefits be weighed properly against the risks for individual patients when considering treatment for anaemia, safety of blood donation, or expected effect of phlebotomy for polycythaemia. primary objective: - compare the per individual and per group effects of a reduction in hb mass on physical functional outcomes (heart rate; activity parameters; qol) in patients with polycythaemia. secondary objectives: - compare the primary outcomes to data from the remote-2 and faint-study (similar measurements in transfusion dependent patients and whole blood donors) study design: within-subject design. patients will be remotely monitored one week before phlebotomy until one week after. study population: adult patients with a polycythaemia requiring phlebotomies on a regular basis. main study parameters: heart rate, blood pressure, activity parameters and quality of life.

Eligibility criteria:
inclusion criteria: * patients with polycythaemia, requiring phlebotomy on a regular basis (at least every 4 months) * subjects aged ≥18 years * in possession of a smartphone * life expectancy ≥ 3 months exclusion criteria: * poor performance/functional status (eastern cooperative oncology group system ecog ≥3) * participants with known arrhythmias or other significant cardiological conductivity disorders (paroxysmal atrial fibrillation is allowed) * hospitalized subjects * subjects with a pacemaker. * subjects with a secondary polyglobulia due to eg smoking or other pulmonary issues. * scheduled oncological treatments or surgery during the study period.
prevalence of undiagnosed chronic obstructive pulmonary disease sufferers in the region of murcia

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the purpose of this study is determine the prevalence of undiagnosed chronic obstructive pulmonary disease (copd) in population served and with exposure to cigarettes in the region of murcia

copd is a serious, chronic and very disabling, associated with smoking and aging. therefore it is a preventable and treatable process. it is know to be a pathology under diagnosed and when diagnosis, this is done in advanced stage, resulting to rise to more complication and more severe, in a addition to a high social and economic cost. therefore, take out an epidemiological study, observational, multicentre, whose main objective is estimate the prevalence of undiagnosed copd in population served between 40 and 70 years and exposure to cigarettes in the region of murcia. other objectives are estimate the proportion of patients already diagnosed, identifying risk factors associated with not previous diagnosis of copd and describe the history of symptoms in them. description of therapeutic manage and motivation to give up smoking. the study was carried out with 120 researcher doctors and 120 researcher nurses from 40 health centers in the region of murcia. each researcher will select 10 patients for the main objective and 10 for objectives related to manage of copd.

Eligibility criteria:
inclusion criteria: 1. aged between 40 and 70 years of both sexes 2. with a history of smoking (current or past) 3. do not diagnosed with copd at the time of completion of study exclusion criteria: 1. prior diagnosis of copd or asthma 2. a condition prevents performing spirometry 3. patients displaced for those diagnosed with copd: inclusion criteria: * subject treated in cs there is explicit evidence for the disease exclusion criteria: * subjects who at the time of the consultation arouse suspicion of previously undiagnosed copd

Keywords: chronic obstructive pulmonary disease diagnosis differential dyspnea/classification dyspnea/etiology
comparison of extremely obese patients undergoing gastric sleeve surgery

Conditions: Obesity, Morbid; Hypertension; Diabetes Mellitus, Type 2

Summary: by the comparison of the preoperative and postoperative data of approximately 160 patients undergoing gastric sleeve surgery, we try to draw conclusions about the effectiveness of gastric sleeve surgery, expected complication rate.

we plan to compare the preoperative and postoperative data of approximately 160 patients undergoing gastric sleeve surgery (android-gynoid, male-female, comparison of patients with different degree of obesity, age comparison, etc.) many preoperative and postoperative data are known about the patients (weight, height, bmi, preoperative comorbidities, heart ultrasound values, respiratory function values, laboratory parameters, smoking habits, rate of weight loss in half a year and one year, etc.). by statistical analysis of these data, we try to draw conclusions about the effectiveness of gastric sleeve surgery, expected complication rate, etc.,

Eligibility criteria:
inclusion criteria: obesity (bmi higher than 30 kg/m2) exclusion criteria: lack of patient consent to the study, pregnancy

Keywords: gastric sleeve operation
risk factors of metabolic control in children and adolescents with type 1 diabetes

Conditions: Type 1 Diabetes

Summary: background: type 1 diabetes is one of the most common chronic illnesses among children and adolescents. although, intensive medical care is provided for these patients, some of them have poor metabolic control. for example, only 21% of adolescents with type 1 diabetes in the usa achieve the recommended average blood sugar concentration (hba1c\<7.5%). this is a major problem, since chronic hyperglycemia is the primary cause of morbidity and mortality in type 1 diabetes and causes several serious complications, for example kidney failure, blindness, and stroke. therefore, the international society for pediatric and adolescent diabetes (ispad) declared psychosocial factors, to be the most important risk factors of poor type 1 diabetes management. aim: the aim of this project is to determine the most important risk factors for poor metabolic control in children and adolescents with type 1 diabetes in a cross-sectional design. method: the sample consists of children and adolescents (school age: 7-18 years), who were diagnosed with type 1 diabetes over a year ago, and who are in care at the university children's hospital of zurich. structured interviews are conducted with the patients and the parents are asked to fill out some questionnaires. additionally, hair samples are collected to investigate the cortisol levels of the past 3 months. the collected data is used to investigate the impact of different psychosocial risk factors including personality and self-efficacy of the patients, stress, social support, family environment, education, and parental factors on the metabolic control (hba1c) in pediatric patients.


Eligibility criteria:
inclusion criteria: * diagnosed with type 1 diabetes over a year ago * in care at the university children's hospital of zurich * german speaking exclusion criteria: * other severe illness that affects the diabetes management * severe developmental disorder * pregnancy

Keywords: type 1 diabetes metabolic control psychosocial risk factors cortisol children adolescents
study of sitravatinib with or without other anticancer therapies receiving clinical benefit from parent study

Conditions: Advanced or Metastatic Solid Malignancies

Summary: a study of sitravatinib alone or in combination with other anticancer therapies in advanced or metastatic malignancies

sitravatinib is a spectrum-selective receptor tyrosine kinase (rtk) inhibitor that inhibits several closely related rtks including the tam family (tyro3/axl/mertk), vegfr2, kit, and met. the current study is designed to allow continued access to sitravatinib and to evaluate the safety and tolerability of sitravatinib alone or in combination with other anticancer therapies in patients who are deriving clinical benefit in a previous parent clinical trial.

Eligibility criteria:
inclusion criteria: * currently receiving sitravatinib single- agent or in combination with other therapeutic agent(s) in another mirati- sponsored protocol * currently tolerating the treatment regimen in the parent protocol * experiencing clinical benefit with or without prior radiographic progression from the treatment regimen in the parent protocol in the opinion of the investigator and the investigator determines that continuing treatment is in the patient's best interest exclusion criteria: * known or suspected presence of other cancer * other life- threatening illness or organ system dysfunction compromising safety evaluation
impact of sars-cov-2 (covid-19) infection, treated in ambulatory care, on long-term quality of life in a parisian military population

Conditions: SARS-CoV2 Infection; Covid19

Summary: in april 2020, a meta-analysis on the long-term sequelae of respiratory syndromes related to seasonal coronaviruses (sars and mers) showed a significant alteration in quality of life, with in particular a decrease in physical and emotional capacities and a deterioration of social life. an improvement of the quality of life is evidenced after 6 months but without reaching the level usually observed in healthy people. the impact of sars-cov-2 infection on quality of life can be explained by the persistence of pleomorphic symptoms in the medium to long term. in the military population, the majority of sars-cov-2 cases present minor to moderate forms of the disease. military personnel have living conditions that differ from those of the general population, in particular because of their geographic mobility, which may be responsible for isolation from the family. this isolation can be regular (we speak of "geographical celibacy" when the soldier is posted in a geographical area far from the family unit) and/or occasional, during missions on the national territory or outside. this singularity justifies a study on the impact of sars-cov-2 (covid-19) infection on the quality of life in this specific population.


Eligibility criteria:
inclusion criteria: * military personnel * covid+: diagnosed with covid-19 and managed in ambulatory care since march 14th, 2020 * covid-: not having been infected with sars-cov-2 exclusion criteria: * hospitalized for covid-19 * having received a treatment against covid-19 (other than paracetamol)

Keywords: quality of life
a study of trifluridine/ tipiracil in chemorefractory mcrc in greece

Conditions: Metastatic Colorectal Cancer

Summary: collection of real world data on the clinical efficacy of trifluridine/ tipiracil (ftd/tpi) in the greek population.

the aim of this analysis is to record clinical practice and to collect real world data on the clinical efficacy of trifluridine/ tipiracil (ftd/tpi) in the greek population. main objectives include to assess physician's choice of treatment in chemoresistant metastatic colorectal cancer with ftd/tpi in third line and beyond in addition, the clinicopathologic features related to metastatic colorectal cancer (focus on molecular profile), duration of treatment, dose modification and toxicity will be analyzed.

Eligibility criteria:
inclusion criteria: * age \> 18 years * histologically confirmed metastatic colorectal cancer * available data on previous chemotherapy lines exclusion criteria: no exclusion criteria have been established for this observational and retrospective study.