Kornimate/medical-research-clean huggingface dataset:
the addition of oral analgesics to let during laceration repair

Conditions: Laceration; Pain

Summary: background approximately 30 million children are treated in emergency departments each year in the united states, of which two to three million are children presenting with lacerations. topical numbing medication is the standard of care in children with regard to pain control during laceration repair. while topical numbing medications are effective, children often require further pain control during laceration repair in the form of an injected numbing medication, which in itself is painful. no evidence currently exists regarding the concurrent use of oral pain medications to combat laceration procedural pain. research question does the addition of ibuprofen or oxycodone to lidocaine, epinephrine, and tetracaine (let) topical anesthetic provide more effective pain control than let alone during laceration repair? design this is a double-blinded, randomized-controlled study. methods subjects in all three groups will receive topical anesthetic. in addition to topical anesthetic, two groups of children will receive either of two oral analgesics, ibuprofen or oxycodone, while the third group will receive a placebo.


Eligibility criteria:
inclusion criteria: * english-speaking patients * patients 4 years of age up to 10 years of age * patients seen in the ed needing simple facial laceration repair * patients with no chronic medical problems exclusion criteria: * any patient who's parent or primary caretaker refuses consent * any patient who's parent or primary caretaker needs an interpreter * any child with complex laceration(s) or bites * any child who has received pain medication at home in response to the facial laceration. * children needing procedural sedation * children with a known allergy to lidocaine, epinephrine, tetracaine, ibuprofen, or oxycodone * patients with known or pre-existing medical conditions where the study protocol cannot be used * this includes any patient with a medical condition that prevents appropriate use of the pain scale * it also includes patients with medical conditions that warrant the use of chronic medications
precision oncology cuhk programme (pro-cure)

Conditions: Gastrointestinal Cancers

Summary: the main aim of this project is to establish an innovative model of a comprehensive precision oncology platform to help individualizing drug therapy for patients with advanced cancers at the chinese university of hong kong. the other objectives include to optimize the genomic matching and access of patients with unique cancer subtypes to the relevant clinical trials of novel therapies, and to construct a personalized drug screening platform for individuals using novel cancer models established from patient-derived cancer cells and tissues. other objectives include to investigate the utility and feasibility of genomic sequencing using circulating tumor dna(ctdna), and to establish a biobank of tumor tissues derived from patients with unique cancer subtypes.


Eligibility criteria:
inclusion criteria: * must be aged between 18 to 75 years * must have ecog performance status of 0 to 1 * must have histologically/cytologically confirmed cancers of certain subtype * medically fit patients who would need systemic therapy as part of their oncological treatment in any one or more of the following oncological setting(s): palliative, neoadjuvant, adjuvant, concurrent with radiotherapy. this includes patients who have limited systemic therapeutic options for their cancers and are candidates for clinical trials. * able to give written informed consent * willing to have blood samples taken. * availability of an archived paraffin-embedded tumor block exclusion criteria: * patients who refuse or are medically unfit for systemic therapy for their cancer * patients with more than one invasive cancers diagnosed over the last five years. * patients without measurable tumor lesions on radiological imaging * patients who are unable to give written informed consent.
a non-interventional pilot study to explore the role of gut flora in ibs

Conditions: Irritable Bowel; Irritable Bowel Syndrome; Irritable Bowel Syndrome With Diarrhea; Irritable Bowel Syndrome Mixed; Irritable Bowel Syndrome With Constipation; Irritable Bowel Syndrome Without Diarrhea; Irritable Bowel Syndrome Aggravated; Irritable Bowel Syndrome Characterized by Constipation; Irritable Bowel Syndrome Characterised by Alternating Bowel Habit

Summary: this study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.

the goal of this research study is to better understand how the genetic information in subject's microbiome correlates to ibs.

Eligibility criteria:
inclusion criteria: 1. signed informed consent, demonstrating that the patient understands the procedures required for the study and the purpose of the study a. may be signed by parent or legal guardian in the case of minor or adult unable to provide consent 2. male or female of all ages 3. diagnosis of ibs exclusion criteria: 1. refusal to sign informed consent form 2. history of bariatric surgery, total colectomy with ileorectal anastomosis or proctocolectomy. 3. postoperative stoma, ostomy, or ileoanal pouch 4. participation in any experimental drug protocol within the past 12 weeks 5. treatment with total parenteral nutrition
effects of home exercise intervention on bone density, muscle functions, qol, and curve progression in girls with ais

Conditions: Adolescent Idiopathic Scoliosis

Summary: studies with exercise intervention aimed to improve the bone health and muscle functions in patients with ais were lacking. evidence suggested that low bone mass and low muscle mass were associated with curve severity and occurrence of ais. weight-bearing exercise that aimed to improve musculoskeletal and metabolic health could enhance bone health and muscle mass, and could provide a feasible alternative conservative treatment to prevent curve progression as well as the quality of life in ais girls. this is a pilot feasibility study for future large randomized controlled trial (rct) aiming at determining the effects of home based exercise program on improving bone mineral density (bmd), muscle mass and functions, quality of life (qol), and prevent curve progression in skeletally immature girls with adolescent idiopathic scoliosis (ais).


Eligibility criteria:
inclusion criteria: * cobb angle greater or equal to 15° * newly diagnosed at the scoliosis clinic without prior treatment * cleared for physical activity by doctor exclusion criteria: * scoliosis with any known etiology such as congenital scoliosis, neuromuscular scoliosis, scoliosis of metabolic etiology, scoliosis with skeletal dysplasia, or * known endocrine and connective tissue abnormalities, or * known heart condition or other diseases that could affect the safety of exercise * eating disorders or gi malabsorption disorders or * currently taking medication that affects bone or muscle metabolism
cranberry juice in the prevention of urinary tract infections in children

Conditions: Urinary Tract Infections

Summary: the objective of the study is to determine whether recurrences of urinary tract infection in children can be prevented with cranberry juice.

five percent of children have at least one uti episode and 30% of these episodes recur. recurrences and the risk of renal damage are indications for long term antimicrobial prophylaxis, but emerging antimicrobial resistance underlines the need for alternatives. the bacteria causing urinary tract infection arise from the stools. dietary changes can alter the balance of faecal bacteria. vaccinium berries and products containing lactobacilli have been shown to act against the coliform bacteria that cause most urinary tract infections. in our previous study cranberry juice was effective in preventing symptomatic recurrences of urinary tract infections in women. the objective of our study is to determine whether recurrences of urinary tract infection in children can be prevented with cranberry juice.

Eligibility criteria:
inclusion criteria: * urinary tract infection 0-2 months priorly exclusion criteria: * antibiotic prophylaxis

Keywords: urinary tract infections cranberry prevention
effects of anesthetics on postoperative cognitive function of patients undergoing endovascular repair of aortic aneurysm and endovascular treatment of arteriosclerosis obliterans of lower extremities.

Conditions: Endovascular Repair of Aortic Aneurysm; Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities

Summary: endovascular repair of aortic aneurysm and endovascular treatment of arteriosclerosis obliterans of lower extremities are two kinds of common surgeries in the investigators' hospital. the effects of anesthetic agents on postoperative outcome, especially cognitive function, are not clear. in this study investigators propose to measure postoperative cognitive function and other outcome of patients who are undergoing these two kinds of surgeries, and try to identify whether there is an association between different kinds of anesthetics and postoperative outcome. investigators will also observe whether changes in plasma levels of vegf, tgf-1, tnf-α, il-1β, and il-6, are associated with postoperative delirium or cognitive change.


Eligibility criteria:
inclusion criteria: * age 18-100 years of age * patients presenting for endovascular repair of aortic aneurysm and endovascular treatment of arteriosclerosis obliterans of lower extremities exclusion criteria: * patients with pre-existing delirium * inablility to converse
dysphagia and quality of life in patients with oral squamous cell carcinoma before and after treatment

Conditions: Oral Cavity Cancer; Dysphagia; Quality of Life

Summary: while the group of oral cavity cancer (occ) survivors continue to increase, surgeons and oncologist intensify their search for improved treatment and rehabilitation methods to reduce the morbidity of management without compromising the oncological safety. the predominant problem after treatment of occ is dysphagia, which is associated with malnutrition, aspiration pneumonia, hospital re-admission, and reduced quality of life (qol) and survival. in a pilot study, the investigators found that 45% of occ patients reported significant eating disabilities two years after surgical treatment. however, the international literature is limited on the dysphagia and qol of occ survivors. with an overall goal to improve the qol and health status in patients treated for occ, the present study aims to 1. systematically evaluate the swallowing function before and after treatment, 2. investigate the impact of swallowing function on qol, 3. identify risk factors for dysphagia, 4. investigate if swallowing function is an independent factor for the number of ´days alive and out of hospital´ 5. evaluate the rehabilitation offered to occ patients in danish municipalities and the effect on swallowing outcomes. one hundred patients treated for occ will be included prospectively during a 2-year period. data on type and location of tumour, treatment modality, complications, patient weight, dietary intake, rehabilitation program, hospital admissions, recurrences, and survival will be collected. questionnaires and modified barium swallow study (mbss) will be performed before and 2 and 12 months after treatment.


Eligibility criteria:
inclusion criteria: * histologically confirmed squamous cell carcinoma with any location in the oral cavity including recurrences. patients will only be included once * treatment with curative intent (surgery and/or (chemo)radio therapy) exclusion criteria: * allergy to barium contrast * pregnancy or breastfeeding * inability or unwillingness to complete questionnaires and undergo examinations

Keywords: oral cavity cancer dysphagia quality of life days alive and out of hospital rehabilitation
the relationship between haemorrhoids and pelvic vein reflux

Conditions: Haemorrhoids

Summary: this case series aims to find out in a group of female patients suffering from haemorrhoids, how many of them have pelvic vein reflux that feeds into their haemorrhoids. this will be done by examining their ovarian and internal iliac veins for reflux, using a transvaginal scan.

based on previous research, we believe that haemorrhoids could be caused by faulty valves in the veins running from deep within the pelvic region to the lower part of the abdomen (internal iliac veins)resulting in reflux in the tributaries. we have already presented research showing that patients with severe pelvic vein reflux, particularly of the internal iliac veins and tributaries, are associated with a higher chance of haemorrhoids. the aim of this study is to see in a group of patients suffering from haemorrhoids, whether all of them exhibit pelvic vein reflux feeding into the haemorrhoids. if we are able to prove that either all or the vast majority of patients with true haemorrhoids do have pelvic vein reflux feeding into them, this will support our hypothesis that the internal iliac vein and tributary reflux is causative of haemorrhoids. following this, in a future study we will treat internal iliac vein and tributary reflux to see if the results of haemorrhoid treatments are improved. if we find only a few patients with haemorrhoids have associated internal iliac vein and tributary reflux feeding into the haemorrhoids, we will be able to refute the hypothesis that there is a causative association, and will not need to progress with the studies and will look instead for a different aetiology. at the current time, there is no effective way of investigating male pelvic vein reflux. the gold standard investigation for pelvic vein reflux is transvaginal duplex ultrasound scan. as such this study will be restricted to females presenting with symptomatically haemorrhoids who are able and willing to undergo transvaginal ultrasound scan to assess their pelvic veins.

Eligibility criteria:
inclusion criteria: * female * symptomatic haemorrhoids * being able and willing to undergo transvaginal ultrasound scan to assess their ovarian and internal iliac veins * aged between 18 and 80 years * good understanding of written and spoken english exclusion criteria: * male * aged younger than 18 or older than 80 * those unwilling to attend for a transvaginal scan at the whiteley clinic, guildford

Keywords: haemorrhoids pelvic reflux
visual quality of cataract patients with high myopia after implantation of different intraocular lenses

Conditions: Cataract

Summary: this prospective study aims to compare the visual outcomes following the implantation of two different types of multifocal intraocular lenses (iols) in highly myopic patients. the study will evaluate visual quality, refractive outcomes, and patient satisfaction using various visual assessment techniques and subjective satisfaction surveys.


Eligibility criteria:
inclusion criteria: * 1: patients are older than 18 years 2: the axial length (al) measured by iolmaster 700 is ≥26 mm 3: no anterior or posterior segment pathology that could potentially compromise visual potential (such as glaucoma, myopic traction maculopathy, corneal leukoma, etc.). 4: able to understand, cooperate, and complete all follow - ups exclusion criteria: * 1: history of amblyopia 2: retinal detachment in the same eye or the fellow eye 3: presence of multiple peripheral retinal degenerative changes 4: history of previous ocular surgery
heart rate reducing therapy in cardiac ct using ivabradine and bisoprolol

Conditions: Bradycardia

Summary: out-patients scheduled for coronary computer tomographic angiography (ccta) were screened regarding their baseline heart rate. if heart rate was \> 75, patients were pretreated with 10mg bisoprolol (group 1) or 10mg bisoprolol plus 7.5mg ivabradine (group 2) to reduce heart rate one our before ccta was performed. heart rate, additional use of i.v. bradycardic agents, motion artefacts, radiation dose and drug tolerance was monitored.

aim of the study is to evaluate if ivabradine, an inhibitor of the funny channel (if), in addition to bisoprolol is effective in lowering heart rate before coronary computer tomographic angiography (ccta) if administered orally one hour before the scan. out-patients of a single radiology center are included in this retrospective analysis. all patients are referred to an ambulant ccta. all scans are performed with a siemens somatom sensation cardiac 64 computer tomograph and analyzed with siemens syngo plaza software. patients with an initial heart rate of ≥ 75 bpm are either pretreated with bisoprolol 10mg p.o. alone (group 1) or a combination of bisoprolol 10mg and ivabradine 7.5mg p.o. (group 2) one hour before the ct scan. the change in treatment from bisoprolol only to the combination of bisoprolol and ivabradine was introduced as a change in standard treatment independent of the study. the study was only plannend and performed as a retrospective analysis after the last patient included into the analysis was already treated. additional betablocker is administered intravenously right before the scan if heart rate remains elevated. the hypothesis is that the addition of ivabradine to bisoprolol results in a pronounced heart rate reduction. this heart rate reduction will lead to a reduced need of i.v. bradicardic drug use, a reduction in motion artifacts and a reduced radiation dose to to a higher rate of flash sequences.

Eligibility criteria:
inclusion criteria: * all comer study exclusion criteria: * none
s.a.f.e.bt system extracorporeal treatment with diapact crrt

Conditions: Severe Sepsis

Summary: the purpose of this study is to determine if selective adsorption system for removal of bacterial toxins (s.a.f.e.bt) therapy is effective in the treatment of severe sepsis.

is extracorporeal treatment effective in the treatment of sepsis

Eligibility criteria:
inclusion criteria * clinical diagnosis of sepsis * mechanical ventilation due to acute pulmonary dysfunction * one additional (second) acute sepsis-related organ dysfunction exclusion criteria * pregnant women and nursing mothers * conditions or medications associated with an increased risk of bleeding/complications from anticoagulation * previous episode of sepsis during this hospitalization * pao2/fio2 ratio \< 300 * severe granulocytopenia (leukocytes \<500 / μl) * acute hepatic diseases or severe liver failure or cirrhosis * chronic cardiovascular disease precluding extracorporeal treatment * human immunodeficiency virus complicated by aids defining illness * evidence of active bleeding - uncontrolled hemorrhage

Keywords: severe sepsis mechanical ventilation
multi-center, randomized, open-label study of g/p +/- rbv for ns5a + sof previously treated gt1 hcv subjects

Conditions: Hepatitis C; HCV

Summary: the study will enroll well-compensated cirrhotic as well as non-cirrhotic subjects treatment experienced with an ns5a inhibitor + sofosbuvir and will include patients who did not complete the prescribed duration due to adverse event or any reason other than for non/poor compliance. subjects will be randomized to 12 or 16 weeks of treatment.

the primary purpose of this study is to compare the efficacy and safety of glecaprevir and pibrentasvir (g/p) for 12 weeks to g/p for 16 weeks in non-cirrhotic ns5a (non-structural protein 5a)-inhibitor plus sofosbuvir ± rbv (ribavirin) treatment-experienced adults with hcv genotype 1 (gt1) infection, and to compare the efficacy and safety of g/p with rbv for 12 weeks to g/p without rbv for 16 weeks in ns5a-inhibitor plus sofosbuvir (sof) ± rbv treatment-experienced adults with compensated cirrhosis and gt1 infection.

Eligibility criteria:
inclusion criteria: 1. male or female at least 18 years of age at time of screening. 2. a history of previous treatment with an ns5a-inhibitor plus sofosbuvir therapy ± rbv for chronic hcv genotype 1 infection. 3. treatment must have been completed at least 1 month prior to screening visit. 4. screening laboratory result indicating chronic hcv gt1 infection. subjects must be able to understand and adhere to the study visit schedule and all other protocol requirements and must voluntarily sign and date an informed consent. exclusion criteria: 1. history of severe, life-threatening or other significant sensitivity to any drug. 2. female who is pregnant, planning to become pregnant during the study or breastfeeding; or male whose partner is pregnant or planning to become pregnant during the study. 3. recent (within 6 months prior to study drug administration) history of drug or alcohol abuse that could preclude adherence to the protocol in the opinion of the investigator. 4. positive test result at screening for hepatitis b surface antigen (hbsag) or anti-human immunodeficiency virus antibody (hiv ab) in patient without known history of hiv infection. 5. hcv genotype performed during screening indicating co-infection with more than one hcv genotype. 6. history or presence of liver decompensation.

Keywords: hcv previously treated
validation of an integrated digital solution (sunrise®) versus polysomnography for obstructive sleep apnea diagnosis

Conditions: Obstructive Sleep Apnea

Summary: validation of an integrated digital solution (sunrise®) of mandibular movement automatic analysis by artificial intelligence versus polysomnography for obstructive sleep apnea diagnosis: a prospective, randomized, parallel-arm, open-label, multicenter, national, controlled study.

the new sunrise integrated digital solution is a disposable 3 gram sensor that sits on the chin for sleep disorders diagnosis. this device records mandibular movements, head movements and position during sleep. data acquisition is done through a mobile application installed on the user smartphone. data is then transferred automatically at the end of the test (overnight) to a cloud platform where it is automatically analyzed. the health care professional (hcp) and the patient have access to sleep parameters and report. the objective of this trial is to determine the place of the sunrise device in the care pathway in france for patients suspected of having osa. the assumption is that sunrise is both non-inferior to the normal practice (i.e., the psg) on sleepiness at 3 months post-diagnosis, and superior to the psg (outpatient or in-lab) in terms of time between inclusion and diagnosis appointment and treatment initiation. by speeding up the treatment initiation, the hypothesis is that sunrise is also superior to the psg on sleepiness as well as quality of life and work productivity at 3 months post-inclusion. another assumption is that sunrise is non-inferior to the psg on cpap compliance at 3 months following treatment initiation. the sunsas study will be launched in 19 centers (public and private) in france and will include 848 patients aged 18 to 80 years. eligible patients will be included and randomized in 2 arms, i.e., the sunrise arm and the psg arm. an appointment to discuss the diagnosis and treatment options (for patients suffering from osa) will be arranged after the procedure (psg or sunrise) is performed. on site follow-up visits will be then organized at 3 months post-inclusion and at 3 months post-diagnosis, and a phone call will be scheduled at 3 months post-treatment.

Eligibility criteria:
inclusion criteria: * man or woman aged between 18 to 80 years old * patient referred for a suspicion of osa * patient having a smartphone and internet connection at home and able to use a mobile application * patient affiliated to the social security system main exclusion criteria: * patient with a previous sleep test performed within 5 years of inclusion * patient previously treated for osa within 5 years of inclusion * patient suffering from severe chronic obstructive or restrictive pulmonary disease with or without oxygen at the discretion of the investigator * patient refusing to shave his beard that could prevent him to wear the device on the chin

Keywords: polysomnography obstructive sleep apnea home sleep test artificial intelligence mandibular movement