Kornimate/medical-research-clean huggingface dataset:
electrocautery vs q-switch for seborrheic keratosis

Conditions: Keratosis, Seborrheic

Summary: the primary objective of this study is to compare the efficacy and risk of adverse events of electrocautery versus 532 nm q-switched neodymium-doped yttrium aluminium garnet (nd:yag) laser for the treatment of flat seborrheic keratoses. this study is a pilot study designed to determine feasibility of these procedures.


Eligibility criteria:
inclusion criteria: 1. subjects are caucasian or asian. 2. subjects who are between 18-65 year olds. 3. subjects have flat or macular seborrheic keratosis on dorsum of the hands and wrists, extensor surfaces of the forearms. the diagnosis of flat seborrheic keratosis is confirmed by two clinical dermatologists using routine clinical examination and dermoscopy. 4. subjects have fitzpatrick skin type i-iii. 5. subjects are in good health. 6. subjects have the willingness and the ability to understand and provide informed consent and communicate with the investigator. exclusion criteria: 1. history of keloids or hypertrophic scars. 2. pregnant or lactating or intends to become pregnant in the next 3 months. 3. active skin disease or skin infection in the treatment area. 4. previous history of lidocaine allergy. 5. history of methemoglobinemia 6. unable to understand the protocol or to give informed consent. 7. any other condition that would, in the professional opinion of the investigator, potentially affect response or participation in the clinical study or would pose as an unacceptable risk to subject.
study on the efficacy and safety of qlm1016 in schizophrenia

Conditions: Schizophrenia

Summary: the study will evaluate the antipsychotic efficacy of qlm1016 in a multicenter, randomized, double-blind, parallel controlled study in patients diagnosed with schizophrenia.


Eligibility criteria:
inclusion criteria: * male or female subjects, ages 18-65 inclusive, with a clinical diagnosis of schizophrenia * panss total score ≥ 70 and ≤ 120，rating of at least 4 (moderate) on at least 2 of the following 4 panss positive symptoms: delusions, hallucinatory behavior, conceptual disorganization, and unusual thought content * cgi-s score ≥ 4 exclusion criteria: * currently, meet dsm-5 diagnostic criteria for other psychiatric disorders ( for example schizoaffective disorder, schizophreniform disorder, bipolar i and ii disorder; pervasive developmental disorder, mental retardation, delirium, dementia, amnestic and other cognitive disorders； * known or suspected borderline or antisocial personality disorder or other psychiatric disorders of sufficient severity to interfere with participation in the study
risk factors for low lymphocyte count in patients with type 2 diabetes

Conditions: Diabetes Mellitus, Type 2

Summary: the purpose of this study is to identify risk factors for low lymphocyte count among patients with type 2 diabetes who are treated with oral antidiabetic drugs.

involving a secondary analysis of data collected prospectively from a defined cohort, for the savor trial.

Eligibility criteria:
inclusion criteria: * enrolled in savor * diagnosed with t2dm * baseline hba1c ≥6.5% (based on the last measured and documented laboratory measurement within 6 months) * age 40 or older * high risk for a cardiovascular event exclusion criteria: * not enrolled in savor * current or previous treatment with dpp4 inhibitors and/or glp-1 or incretin mimetics. * acute vascular event * pregnancy * hiv/aids * severe autoimmune disease * current chronic steroid use
patients with coronary artery disease or at high cardiovascular risk: measuring compliance with treatment for obstructive sleep apnea syndrome

Conditions: Obstructive Sleep Apnea; Coronary Disease; Cardiovascular Diseases

Summary: obstructive sleep apnea (osa) is a sleep disorder characterised by partial or total obstruction of the oro-pharyngeal carrefour during sleep. it is found in between 4% and 25% of the general population and in 40 to 80% of patients with cardiovascular diseases. continuous positive airway pressure (cpap) is the standard treatment for osa and its efficacy has already been demonstrated in this particular population. however, this treatment is not always accepted or sufficiently tolerated. the mandibular advancement device (mad) is therefore an alternative treatment for osa, validated by the french national authority for health and particularly relevant in this population because it is generally better tolerated. the aim of our study was to assess compliance, tolerance and usability of cpap and mad in patients with coronary artery disease and moderate (apnea-hypopnea index ahi 15-30) to severe (ahi\>30) osa.


Eligibility criteria:
inclusion criteria: target population: with coronary artery disease or at very high risk of coronary artery disease: * patients with coronary artery disease with or without co-morbidities (smoking, diabetes, hypertension, dyslipidaemia, renal insufficiency, overweight, emerging factors including anxiety-depression, shift workers, etc.). * hypertensive patients at high cardiovascular risk (target organ damage such as lvh or albuminuria) * diabetic patients at high cardiovascular risk * type of heart disease: ischaemic heart disease without clinically significant heart failure (nyha ii, iii, iv) for the experimental group (mad): patients with moderate or severe osa with intolerance or refusal of cpap and managed by mad. for the control group (cpap): patients with moderate or severe osa treated with cpap. exclusion criteria: * patients with heart failure not stabilised according to the investigator (nyha iv) * severe psychiatric disorders * pregnant or breast-feeding women * opposition to participation after a period of reflection * not affiliated to a social security scheme, * persons under court protection, * persons under guardianship or curatorship * person taking part in another study with an exclusion period still in progress * inability to follow the patient during the study period.
study evaluating safety of bmp-655/acs as an adjuvant therapy for rotator cuff repair

Conditions: Rotator Cuff Tear

Summary: study to assess the safety of 3 differing concentrations of bmp-655/acs in subjects with full thickness rotator cuff tears (rcts).

this decision to terminate enrollment in this study is based on the company's change in prioritization for the portfolio and was not due to any safety concerns, or regulatory interactions. patients already enrolled in the study, should continue to complete assessments as described in the protocol.

Eligibility criteria:
inclusion criteria: * male subjects and surgically sterile or postmenopausal female subjects between the ages of 25 and 75 years old with specific full-thickness rcts identified on closed mri within 3 months before surgery. exclusion criteria: * subjects who have had previous surgical intervention to the shoulder joint under study or additional injury requiring surgical repair or a history of shoulder dislocation in the affected shoulder or physical examination findings of instability in either shoulder * subjects who are unable to complete functional evaluations because of any other concurrent injuries or impairment in either the arm * subjects identified with specific fatty infiltration of their rc muscles on mri taken within 3 months prior to surgical repair * subjects with moderate or severe degenerative arthritis of the shoulder under study or any bone abnormalities as confirmed on a radiograph * subjects with rheumatologic conditions affecting the shoulder joints or autoimmune disorders, treated with more than 3 corticosteroid injections in the shoulder under study within 1 year of planned surgery, any recent corticosteroid injection in the shoulder or currently receiving oral corticosteroids * subjects who are either unwilling or unable to undergo examination with closed mri.

Keywords: rotator cuff tear repair open surgical technique safety
effects of dnhs technique in the treatment of upper limb spasticity and function in stroke

Conditions: Stroke; Spasticity

Summary: introduction: stroke is a neurological deficit caused by a decrease in cerebral blood flow. the dnhs ® (dry needling for hypertonia and spasticity) technique is a dry needling technique to reduce spasticity and hypertonia and improve function in patients with cns injury. the main objective of this trial is to analyze the therapeutic effect of dnhs® technique in motor function in patients between 45 and 80 in a chronic state after a stroke. methods: double-blinded randomized clinical trial. there will be an intervention group (dnhs® technique) and a sham control group. the intervention will be 2 sessions, one per week, in biceps brachii, brachialis, flexor digitorum superficialis nad profundus, adductor pollicis and first dorsal interossei. the fugl meyer assessment scale, modified ashworth scale and stroke impact scale will be used as outcome measures. the data will be expressed as mean ± (standard deviation). the standardized difference or effect size (es, 90% confidence limit) in the selected variables will be calculated.


Eligibility criteria:
inclusion criteria: * people aged 40-85 years with hemiplegia resulting from stroke of more than 6 months evolution (chronic stroke) * ability to follow instructions and reply to assessment questonnaires exclusion criteria: * recurrent stroke episodes * other concomitant neurodegenerative conditions * fear to needles * participation in a parallel study * any absolute contraindication for deep dry needling

Keywords: stroke spasticity dry needling upper motor neuron syndrome motor function
effect of leg elevation on prevention of intraoperative hypotension during beach chair position

Conditions: Intraoperative Hypotension; Cerebral Ischemia; Shoulder Disease

Summary: the aim of this study is to evaluate the effect of leg elevation on the prevention of intraoperative hypotension during shoulder surgery in the beach-chair position. patients undergoing shoulder surgery in the beach-chair position will be randomly assigned to group l (with leg elevation) or group c (no intervention). the primary outcome is the incidence of intraoperative hypotension (mean blood pressure \< 60mmhg or systolic blood pressure \< 80% of baseline). secondary outcomes are the incidence of intraoperative cerebral desaturation (cerebral oxygen saturation \< 80% of baseline, longer than 30 seconds), total amounts of administered inotropic agents, and systolic blood pressure, heart rate, and cerebral oxygen saturation at various time points.


Eligibility criteria:
inclusion criteria: * adult patients undergoing shoulder surgery in the beach chair position exclusion criteria: * patients with myocardial infarction * patients with pacemaker * patients with cerebrovascular disease * patients with arteriovenous fistula at the opposite arm * patients with autonomic nerve disorders * patients with hip or knee joint disorder limiting hip or knee flexion * bmi \> 30 kg/m2
effect of a postural re-education intervention compared to standard care on scoliosis progression in adolescent

Conditions: Adolescent Idiopathic Scoliosis

Summary: the aim of this project is to verify the effect of the global postural reeducation (gpr) intervention used in physiotherapy on scoliosis progression (scoliosis angle), back pain, quality of life, respiratory function, trunk posture and trunk muscle functioning and walking endurance. to do so, we will recruit 144 participants at three scoliosis specialized centers. participants will be randomly allocated to the standard of care (sc) group (observation or brace plus home video of exercises for 12 months) or to the gpr group (sc plus individual sessions once a week for 6 months and individual sessions alternating with telerehabilitation sessions once per two weeks between 6 and 12 months). at initial, 6, 12- and 24-months evaluation, participants will have x-ray, complete self-report questionnaires to document back pain and quality of life. thereafter, measurement of trunk posture, electromyography activity of the back muscles, excursion of the diaphragm muscle using echography and respiratory function as well as distance covered using the 6-minute walk test for walking endurance will be done. we believe that gpr intervention may prevent scoliosis progression and improve physical health and quality of life in adolescence.


Eligibility criteria:
inclusion criteria: * aged between 10 and 16 years old, * cobb angle between 15º and 45º, * risser sign ≤3 (skeletal growth incomplete), * with a risk of progression index \> 1.3, * having recent x-rays (4-6 weeks), * ability to travel weekly to attend gpr intervention exclusion criteria: * patients with diagnosis other than ais, * patients who are planned for surgery, * have had surgery, * worn a brace for at least three months prior to gpr intervention

Keywords: adolescent idiopathic scoliosis global postural re-education back pain quality of life trunk imbalance inter muscular coherence respiratory function functional performance
pipamperone/citalopram (pipcit)versus citalopram in the treatment of major depressive disorder(mdd)

Conditions: Depression

Summary: the primary objective is to demonstrate whether the addition of pipamperone 5 mg twice daily (bd) to citalopram, 40 mg daily in patients suffering from mdd will improve the efficacy of citalopram 40 mg in these patients. secondary objectives are to demonstrate whether the addition of pipamperone 5 mg twice daily (bd) to citalopram, 40 mg daily in patients suffering from mdd: 1. will increase the rate of resolution of symptoms with citalopram 40 mg. 2. show the combined product to be safe and tolerable. patients are scheduled to receive study medication for eight weeks and a final follow-up check will be carried out 28 days after completing the study. all patients will receive active citalopram from baseline and will be randomised to receive either active pipamperone or a placebo equivalent for eight weeks during which time they will attend for 6 study visits.


Eligibility criteria:
inclusion criteria: * male and female patients * 18-65 years inclusive * suffering from a moderate to severe mdd as defined by dsm iv with an existence of depressed mood and loss of interest/anhedonia for at least four weeks and no longer than six months for the current episode * diagnosis will be confirmed by the mini international neuropsychiatric interview (mini) version 5.0.0. * clinical global impression - severity scale (cgi-s) rating of at least four and a minimum hamilton depression scale (ham-d) 17 items total score of 18 at screen and baseline * a non-psychotic state * where appropriate, male patients should agree to use barrier contraceptive measures (condoms) during the course of the study and for three months after the last dose of medication exclusion criteria: * premenopausal females not using adequate contraceptive measures * considered by the investigator to be a significant risk of suicide or scoring 5 or more on the madrs question 10 * significant other psychiatric illness which would interfere with trial assessments - co-morbid generalised anxiety disorder (gad) and panic disorder will be permitted where mdd is considered the primary diagnosis * significant physical illness which would interfere with trial assessments * reduced hepatic function * epilepsy * history of cardiac dysrhythmia * alcohol intake above accepted uk ranges * recent (1 week) antidepressant (except for fluoxetine - 4 weeks and st john's wort or maoi's - 14 days), benzodiazepine or any other psychotropic medication ingestion including lithium or other mood stabilisers * resistant depression defined as having failed to respond to * two previous antidepressants at an adequate dose ingested for at least 4 weeks during the current episode * to an augmentation therapy with an atypical antipsychotic drug * electroconvulsive therapy (ect) for the current episode * formal psychotherapy or alternative treatments for one week prior to or during the study

Keywords: lost of interest, depressed mood
comparing two surveillance approaches for people who have received treatment for hpv-associated head and neck cancer and show no signs of disease

Conditions: Squamous Cell Carcinoma

Summary: the purpose of this study is to compare standard surveillance with telemedicine surveillance (tele-surveillance) and find out which surveillance approach is best for people with hpv-associated head and neck cancer who have no evidence of disease after treatment. the researches will look at how the two approaches affect participants' quality of life, health outcomes, and expenses (for example, costs of routine visits and procedures). they will also determine doctors' and patients' satisfaction with tele-surveillance.


Eligibility criteria:
inclusion criteria: * age ≥ 18 * ecog 0-3 * pathologically (histologically or cytologically) diagnosis of hpv associated squamous cell carcinoma of the oropharynx (tonsil, base of tongue, or oropharyngeal walls) * no evidence of disease on post-treatment pet/ct within 9 months of completing radiation therapy. no evidence of disease is a consensus determination by the patient's radiation, medical, and surgical oncologist. if the first pet/ct is equivocal, then a second pet/ct can be obtained within 9 months of completing radiation therapy. * post-treatment diagnostic imaging with either ct or mri (recommended but not required) * able to speak and read english fluently * able to provide informed consent exclusion criteria: * patients on clinical trials related to head and neck cancer that have protocol defined follow up activities * incomplete response or recurrent disease on post-treatment pet/ct * completion of radiation and chemotherapy more than 9 months ago

Keywords: tele-surveillance remote symptom monitoring 21-347 hpv-associated head and neck cancer
study for evaluation of newly onset chest pain and rapid diagnosis of myocardial necrosis

Conditions: Acute Myocardial Infarction

Summary: this is a national multi-center, prospective surveillance study in patients with suspected acute coronary syndrome. eligible patients must present to one of the participating emergency departments within 24 hours from the time of symptom onset. approximately 2000 patients \>18 and \<85 years of age are planned to be enrolled. upon enrollment in the emergency department, a venous blood sample will be obtained from each patient for analysis. the patient's diagnostic work-up, treatment and disposition will continue per the standards of the treating institution. results will be recorded for ecgs, any cardiac biomarkers measured at the site and any follow-up cardiac objective tests performed for evidence of coronary artery disease and/or myocardial damage (exercise treadmill, coronary angiography, cardiac thallium or technetium scintigraphy, etc). the principal investigator at each site will evaluate the results of the diagnostic cardiac tests performed for that patient to determine whether each patient enrolled at their site has a final diagnosis of acs. the status of each patient will also be assessed at 1 month and 6 months after enrollment for intercurrent major adverse cardiac events (mace), including myocardial infarction, cardiac revascularization and death.


Eligibility criteria:
inclusion criteria: * only patients who are able to give consent. this has to be carefully verified in each case, by the doctors leading the study * men or women \>18 and \<85 years of age * patients with chest discomfort within last 24h and suspected acute coronary syndrome (stemi, nstemi and unstable angina) * patient experiencing at least 30 minutes of chest discomfort or other symptoms consistent with possible acs; (note: patients who have symptoms of shorter duration that resolved due to pharmacologic intervention may be included.) * written informed consent exclusion criteria: * age \ 85 years * inpatient in the hospital prior to onset of symptoms. * obvious traumatic disease * prisoners or other institutionalized or vulnerable individuals * major surgery within last 4 weeks * patients with cardiogenic shock * other significant laboratory abnormalities that the investigator feels may compromise the patient's safety by participation in the study * women who are pregnant or breast feeding * obvious iv drug abuse * refusal to provide written informed consent * unavailability of a telephone number and insufficient contact information as well as permanent residence abroad * unreliability as a study participant as based on the investigator's prior knowledge of the patient, such as the inability or willingness to participate in or complete the study or the presence of concurrent physical or psychological disorders that may make it impractical for the patient to participate in or complete the study

Keywords: acute myocardial infarction troponin emergency department
kangaroo mother care to prevent hypothermia in term infants

Conditions: Hypothermia; Newborn

Summary: the overall hypothesis is that better adherence to kangaroo mother care (kmc) in combination with existing who thermoregulation care will reduce the incidence of moderate hypothermia (32-36 degrees c) or severe hypothermia (\<32.0 degrees c) in term infants (greater than or equal to 37 weeks of gestational age) when compared with routine who thermoregulation alone.

the overall hypothesis is that better adherence to kangaroo mother care (kmc) in combination with existing world health organization (who) thermoregulation care (warm delivery rooms, immediate drying after birth, kmc whenever possible, early and exclusive breastfeeding, postponement of bathing and weighing, appropriate bundling, and use of air incubator, radiant warmer, or heat mattress if the neonate develops hypothermia) will reduce the incidence of moderate hypothermia (32-36 degrees c) or severe hypothermia (\<32.0 degrees c) in term infants (greater than or equal to weeks of gestational age) when compared with routine who thermoregulation alone.

Eligibility criteria:
inclusion criteria: * estimated gestational age greater than or equal to 37 weeks * delivery in the hospital exclusion criteria: * abdominal wall defect or myelomeningocele * major congenital anomalies * blistering skin disorder

Keywords: hypothermia hyperthermia kangaroo mother care newborn
evaluation of new diagnostic and treatment algorithm for obstructive sleep apnea

Conditions: Sleep Apnea

Summary: newer home sleep study device and algorithm provides an alternative for inpatient sleep study and improve the service provides to patients

purpose: assess different potential algorithms to improve the service and cost utility for diagnosis and treatment of obstructive sleep apnea syndrome (osas) in patients with high pretest probability in hong kong. hypothesis: newer home sleep study device and algorithm provides an alternative for inpatient sleep study design: prospective randomized study subject: high pretest probability of osas patients referred to a tertiary centre. study instruments: a portable sleep study device, autocpap and inpatient sleep monitoring system. interventions: comparison between 3 different algorithms of health service for osa patients would be made: conventional in-patient sleep study, empirical treatment and home sleep study. main outcome measures: the primary outcome is the validity of the home sleep study device compare to inpatient sleep study. the secondary outcomes are the relative efficacy of different algorithms and the numbers of failed procedures in each algorithm.

Eligibility criteria:
inclusion criteria: * adult patients with high pretest probability of osas, i.e. ess \> 10 or symptomatic patients, with bmi \> 23 and/or cranial facial features associated with osa, as assessed by the attending respiratory physician in the respiratory clinic. * patients aged between 18-65 years who agree to participate in the study. exclusion criteria: * pregnant women * patients who refuse signing consent of the study * do not have high pretest probability of osas * refuse to have home sleep study * refuse any treatment offered; or * could not comply with the set up of home study.

Keywords: health utility home sleep study