Kornimate/medical-research-clean huggingface dataset:
relational and emotional mechanisms of a supportive-expressive group intervention in breast cancer

Conditions: Breast Neoplasms; Breast Cancer

Summary: to test the feasibility of supportive-expressive group intervention (segt) for women with primary breast cancer and to provide a preliminary test of its efficacy.

this study aims to compare the efficacy of a 16-sessions group intervention (supportive-expressive group therapy) versus control group (no intervention) in women with primary breast cancer. this study tries to evaluate the efficacy of segt on breast cancer patients' emotion regulation, social support, caregiving, and marital satisfaction, and its improvement on breast cancer patients' life quality. this study also intents to explore the moderating role of attachment on these associations.

Eligibility criteria:
inclusion criteria: * diagnosis of primary breast cancer exclusion criteria: * attendance at a cancer support group or individual psychotherapy * diagnosis of recurrent breast cancer * severe psychiatric disorder * history of drug or alcohol abuse

Keywords: psychological intervention breast cancer supportive-expressive group therapy emotion regulation social support attachment quality of life
effects of prevena therapy on obese and or diabetic patients with surgical groin sites

Conditions: Obesity; Diabetes; Peripheral Vascular Disease

Summary: the purpose of the study is to determine the effects of prevena therapy on decreasing groin surgical site infections in patients who are obese and /or diabetic having vascular surgery.

patients who are obese and/or diabetic may have poor surgical healing and infection rates higher. the prevena therapy will be used to evaluate possible reduction of infection rates in this patient population

Eligibility criteria:
inclusion criteria: * subjects over 18 years old * obese (bmi \> 30) and or diabetic exclusion criteria: * current infected surgical field, hemodialysis, immunosuppressive therapy, allergy to adhesive, sensitivity to silver

Keywords: groin incisions
raloxifene in treating patients with persistent or recurrent endometrial cancer

Conditions: Endometrial Cancer

Summary: rationale: estrogen can stimulate the growth of endometrial cancer cells. hormone therapy using raloxifene may fight endometrial cancer by reducing the production of estrogen. purpose: phase ii trial to study the effectiveness of raloxifene in treating patients who have persistent or recurrent endometrial cancer.

objectives: i. determine response rate and time to disease progression in patients with recurrent endometrial cancer treated with raloxifene. ii. determine overall survival in these patients treated with this regimen. iii. determine the toxicity of raloxifene in this patient population. outline: patients receive oral raloxifene daily. treatment continues indefinitely in the absence of disease progression or unacceptable toxicity. patients are followed every 3 months. projected accrual: a total of 13-50 patients will be accrued for this study within 2.5 years.

Eligibility criteria:
disease characteristics: recurrent endometrial cancer evidence of persistent or recurrent disease 4 weeks following primary treatment with radiation and surgery bidimensionally measurable disease not a candidate for curative salvage radiotherapy patient characteristics: age: 18 and over performance status: ecog 0-3 life expectancy: not specified hematopoietic: not specified hepatic: not specified renal: not specified cardiovascular: no history of unexplained or uncontrolled thromboembolic disease no active thromboembolic disease other: no active or uncontrolled second malignancy hiv negative prior concurrent therapy: biologic therapy: not specified chemotherapy: at least 4 weeks since prior chemotherapy for early stage or advanced endometrial cancer endocrine therapy: at least 4 weeks since prior hormonal therapy for early stage or advanced endometrial cancer radiotherapy: see disease characteristics surgery: see disease characteristics

Keywords: recurrent endometrial carcinoma
a trial of the forecyte breast aspirator for cytological testing of nipple aspirate fluid in women 30-55 years old

Conditions: Breast Cancer, Preneoplastic Conditions, BRCA

Summary: the purpose of this study is to measure the performance of the forecyte breast aspirator for the collection and processing of nipple aspirate fluid (naf) specimens for cytology. including collecting, processing and shipping samples, training staff, processing samples, sample interpretation and accurate and timely reporting in a manner resembling routine clinical use. the study will include a subset of patients who are known carriers of a brca germline mutation. naf from this subset will be submitted for molecular testing in addition to cytology.


Eligibility criteria:
inclusion criteria: 1. healthy, female, age 30-55 years, from whom bi-lateral specimens can be obtained. the following additional considerations apply: * women with prior mastectomy/lumpectomy may be considered for naf-collection in the contralateral (non-operated) breast only if they were: * stage i or stage ii at the time of surgery; * have completed any and all hormonal therapy, chemotherapy, or targeted therapy at least one year prior to inclusion; * are considered disease-free (ned- no evidence of disease) at the time of study entry; * women under the age 30 may be enrolled if they are within 10 years of the age at diagnosis of breast cancer in a first-degree relative. no subject under the age of 21 may be enrolled. 2. any woman for whom naf-cytology testing is considered to be beneficial by her physician. this includes, but is not limited to women with first- and/or second degree relatives with breast- or ovarian cancer. known presence of a brca-1 or brca-2 germline mutation is allowed but not required. if known, any such mutation will be noted on the case report form. the protocol does not provide for testing of women without known germ-line mutations. 3. non-lactating and non-pregnant. 4. good general health as determined by medical history, breast disease/cancer history, and clinical breast exam. 5. willing to give informed consent and follow study procedures as directed. exclusion criteria 1. medical condition/psychiatric conditions making subjects a poor candidate for study, as determined by the principal investigator. 2. pregnancy or suspicion of pregnancy. 3. open cutaneous wounds or atopic dermatitis in the area of the nipple-areolar complex. 4. no or inverted nipple on the breast unfit for fluid collection, or significant prior surgery in the area of the nipple-areolar complex. 5. participation in an investigational drug or device study less than 30 days prior to enrollment in this study. 6. pregnancy, childbirth, or lactation less than 90 days prior to enrollment in this study. 7. acute illness, including taking antibiotics, analgesics, antipyretics and/or cold medications less than 7 days prior to enrollment in this study.
norepinephrine administration through a midline catheter in an intermediate care unit

Conditions: Septic Shock; Norepinephrine Adverse Reaction; Hypotension and Shock

Summary: this is a single-center study retrospectively evaluating a local clinical routine to administer norepinephrine in midline catheters, with regard to complications and patient outcomes

se attached study protocol

Eligibility criteria:
inclusion criteria: * administration of norepinephrine in a midline catheter in an intermediary care unit * in skåne university hospital * from 2019 to 2023-03-31 exclusion criteria: * patients who have actively disabled review of their electronic medical record

Keywords: vasopressor norepinephrine septic shock midline catheter thrombosis extravasation catheter-related bloodstream infection
aggravated airway inflammation: research on genomics and optimal operative treatment (airgos operative)

Conditions: Sinusitis, Chronic; Asthma; Nasal Polyps; Aspirin Sensitivity

Summary: this randomized study compares operative techniques in chronic rhinosinusitis with polyposis (crswnp) surgery. it aims to evaluate outcomes in asthma and crswnp, safety and costs. the investigators want to see if patients with certain clinical and/or genetic predispositions will benefit from extended surgery. they also aim to find biomarkers for detection and management models for of severe airway inflammation and to further develop markers for progressive disease forms.

please see study protocol

Eligibility criteria:
inclusion criteria: * patient not responding to conservative treatment of 3 months of nasal steroid drops * nasal polyp score ≥ 4/8 * snot-22 ≥ 30 * lund-mackay ct score ≥ 14 * one previous endoscopic sinus surgery or at least one peroral corticosteroid course or at least 3 courses of antibiotics within 2 years exclusion criteria: * age \ 65 years * complication of crs (f.e. mucocele, invasive fungal rhinosinusitis) * other diagnosis than crswnp (inverted papilloma, antrochoanal polyp etc.) * previous external sinus surgery or draf 3 procedure (or indication for external approaches or draf 3 * bleeding diathesis * pregnancy/ breastfeeding * cystic fibrosis * primary ciliary dyskinesia (pcd) * sarcoidosis * granulomatosis with polyangitis (gpa) * eosinophilic granulomatosis with polyangitis (egpa) * immunosupression (diagnosed spesific antibody deficiency (sad), common variable immunodeficiency (cvi), hiv or use of biologicals/immunosuppressive medication) * immunotherapy * daily use of systemic corticosteroids * communication problems (f.e. neurological/psychiatric disease, language skills) * unlikely to comply * other severe disease * inability to be operated.
respiatory viral infections in patients with multiple myeloma

Conditions: Multiple Mieloma; Respiratory Viral Infections

Summary: respiratory viruses are known to be a major cause of morbodity in multiple myeloma patients but prospective long-term sudies are lacking. we analysed 219 multiple myeloma patients that had 554 nasopharingeal swabs with 58 documented viral episodes. respiratory viruses studied were rhinovirus, enterovirus, parainflienza, respirator, syncytial virus, metapneumovirus, coronavirus, bocavirus, influenza a, influenza b. clinical data were extracted from a prospectively entered database, medical records were reviewed. we have prospectively studiend patients until may 2019 when we gathered survival data. lastly because of covid-19 pandemic when almost no other viral infections were isolated, we analysed clinical course of respiratory infections in patients with multiple myeloma after the pandemic.


Eligibility criteria:
inclusion criteria: * patients with multiple myeloma exclusion criteria:other hematological malignancies -

Keywords: respiratory viral infections
clinical trials of five different food supplements with restriction diet in adults

Conditions: Overweight and Obesity; Inflammation; Hypercholesterolemia; Hypertension

Summary: in recent years, dietary supplement are of great interest for the improvement of human health. this study is designed as a parallel, randomized, double blind study exploring the efficacy of two months daily oral dosing of five different food supplements together with diet restriction in 120 otherwise healthy overweight or obese adults on different biochemical and anthropometric parameters.

the incidence of obesity has been rapidly increasing, and this condition has become a major public health threat, since it is strongly linked with increased risk for several diseases including type 2 diabetes, cardiovascular disease, cancer and brain aging. obesity and overweight are chronic disorders of multifactorial origin that are characterized by high oxidative status and by low chronic inflammation. thus far, molecular mechanisms underlying obesity and obesity-related metabolic disorders have not been fully clarified, and effective therapeutic approaches to lower inflammation and oxidative stress are currently of general interest. in recent years, dietary supplement and are of interest for the improvement of human health. this study is designed as a parallel, randomized, double blind study exploring the efficacy of two months daily oral dosing of five different food supplements together with diet restriction in 120 otherwise healthy overweight or obese adults on different biochemical (lipid profile, glucose, c-reactive protein, bilirubin, alanine aminotransferase, etc), and anthropometric parameters (body mass, the percentage of body fat, visceral fat index, etc,...). food supplements are mainly composed of different fiber and other bioactive compounds.

Eligibility criteria:
inclusion criteria: bmi \> 25 kg/m2 * bmi \> 25 kg/m2 * personally signed and dated informed consent form * ability to understand and willingness to comply with all protocols required visits assessments and interventions exclusion criteria: * use of dietary supplements * use of medication for any component of metabolic syndrome * presence of inflammatory and/or autoimmune disorders * pregnancy or lactating

Keywords: food supplements diet metabolic syndrome
comparison of balance and coordination parameters of visually impaired and healthy individuals

Conditions: Blindness Congenital

Summary: the aim of this \[observational study\] is to examine balance in multiple aspects by comparing balance, coordination, and gait parameters between congenitally blind individuals and healthy individuals with multiple scales. the main questions it aims to answer are: is there a difference in balance and coordination between congenitally blind individuals and healthy individuals? comparison group: healthy sedated individuals participants will be asked to complete balance scales.

visually impaired, with all corrections, individuals who have one tenth of the usual visual acuity of the seeing eye, i.e. 20/200 visual acuity or less, or whose visual angle does not exceed 20 degrees are called blind. the meaning of 20/200 is that an individual affected by visual impairment can see from 60 cm, while an individual with normal vision can see from 6 m. narrow angle of vision means that, despite normal visual acuity, vision is limited only to the centre, 20 degrees, and objects beyond 20 degrees cannot be seen. balance depends on the integration of information received from proprioceptive, vestibular and visual sensory systems. it has been observed that visually impaired individuals have problems in postural stability and balance due to insufficient information from the visual system. in this study, it was aimed to compare the balance, coordination and gait parameters of congenitally visually impaired individuals and healthy sedentary individuals.

Eligibility criteria:
inclusion criteria: * 18 years of age or older * congenital visual impairment * not having any acute or chronic disease other than congenital blindness exclusion criteria: * having musculoskeletal deformity * being involved in a professional sport * having received physiotherapy treatment for balance before

Keywords: complete blindness visual impairments posture balance
using yogic breathing to reduce stress in anesthesia personnel as measured by hair cortisol

Conditions: Stress; Burnout, Professional

Summary: mind body exercises have long been used as a way for individuals to reduce stress and improve well-being. recent studies indicate that yogic breathing (yb, also known as pranayama) could potentially impact both the mind and body by engaging both the physiological and neural elements and can thus be a specific tool that can be utilized by healthcare workers to combat burnout and decrease perceived levels of stress. our aim is to understand and measure both subjectively and objectively the effects of long-term yogic breathing on stress levels in anesthesia personnel. this will be a single arm longitudinal trial designed to evaluate the feasibility and estimate the efficacy of implementing a yogic breathing program for stress reduction among anesthesiology practitioners at one academic medical center. the primary aim of the trial is to estimate the correlation between participant stress with average duration of yogic breathing over time. secondarily the feasibility of implementing yogic breathing practices among anesthesiology practitioners will be evaluated. feasibility measures will include recruitment rates, retention at 1year follow-up, and adherence to the yogic breathing program at 12 months.


Eligibility criteria:
inclusion criteria: * all clinical members of the musc anesthesia department (attending physicians, resident physicians, and crnas) exclusion criteria: * pregnancy (or anticipated pregnancy) * chronic steroid use * inadequate hair length for testing (less than 3cm at the back of the head) * residents with anticipated graduation within the next one year.
mobility protocol adapted for advanced visually impaired subjects

Conditions: Pigmentary Retinopathy

Summary: retinitis pigmentosa is characterized by a progressive disappearance of photoreceptors, responsible for a progressive and severe loss of vision. people retinitis pigmentosa therefore encounter a large number of difficulties in daily life, specifically for: * visual research * visuo-motor coordination in tasks requiring fine motor control * visuo-motor coordination in mobility tasks this study aims to assess the difficulties in the daily life of subjects with retinitis pigmentosa at a very advanced stage unsing, quaify of life questionnaires, simplified locomotion tasks in real situation and a posture task. they are proposing a new test adapted and carried out in real situations, in binocular and monocular vision, making it possible to finely assess locomotion especially for "very low vision" patients. this test will also ultimately make it possible to better evaluate the effectivements, that is to say to observe and quantify objectively by a score the performance progression obtained for locomotion tasks related to the visual recovery generated by the treatment.

this is monocentric study and the total duration of the study is 48 months. the duration of participation for each research subject is 3 months and maximum 4 visits. this is research involving the human type of non-invasive interventional research, with minimal risks and constraints. this exploratory study will be conducted on a group of patients with retinitis pigmentosa at a very advanced stage. there will be an inclusion visit including a visual assessment and an ophthalmological consultation. two experimental visits with tests carried out in a real environment including a locomotion and a posture tasks. an end-of-study visit within a maximum of 1 month following the second experimental visit.

Eligibility criteria:
inclusion criteria: * retinitis pigmentosa, non-syndromic, the diagnosis of which has been confirmed by an ophtmalmologist * etdrs visual acuity less than 2/10 (\>+0.7 logmar; \<20/100 snellen) * doesn't participate in clinical research that may interfere with this study * sufficient knowledge of the french language to ensure a perfect understanding of the tasks to be performed and the instructions received * consent to the study signed after information by the investigator * health insurance affiliation exclusion criteria: * pregnant women * inability to give personal consent * cataract surgery in the 3 months preceding inclusion * amblyopia * inability to comply with the instructions for carrying out the study tasks or to complete the study visits * mmse score without visual item ≤ 20/25 * drug treatment which can lead to motor, visual or cognitive disorders (psa, neuroleptics,etc.) or which may interfere with the study's evaluations
study to assess the safety and tolerability of ang-3070 in subjects with idiopathic pulmonary fibrosis

Conditions: Idiopathic Pulmonary Fibrosis (IPF)

Summary: the purpose of this study is to assess safety and tolerability of once daily (qd) and twice daily (bid) dosing of ang-3070 in subjects with idiopathic pulmonary fibrosis (ipf) who are treatment-naïve, refused therapy, or discontinued for any reason current standard of care with nintedanib or pirfenidone.


Eligibility criteria:
inclusion criteria: 1. subject must be willing and of sufficient mental capacity to give written informed consent and comprehend the importance of adhering to study treatment and requirements. 2. male or female subjects aged 40 years and older at the time of informed consent. 3. substantiated diagnosis of ipf based on clinical, radiological, and/or pathologic data to the exclusion of alternate diagnoses that would contribute to extant interstitial lung disease (ild) based on the opinion of the subject's physician using current diagnostic criteria. 4. subject: * is naïve to therapy with nintedanib or pirfenidone or * refuses therapy with nintedanib or pirfenidone or * had nintedanib or pirfenidone discontinued due to any reason, 4-week washout required exclusion criteria: 1. diagnosis of asthma or chronic obstructive pulmonary disease (copd). 2. current tobacco use (quit at least 1 month prior to study for inclusion). 3. presence of active infection requiring ongoing therapy with systemic antibiotics and/or antivirals. 4. diagnosis of connective tissue disease. 5. known cause of ild diagnosed. 6. active malignancy aside from local carcinoma. 7. ast or alt or total bilirubin \> 2x upper limit of normal (uln). 8. pregnancy and/or lactation; positive serum beta human chorionic gonadotropin (β-hcg) during screening.
fludrocortisone for sudden hearing loss

Conditions: Hearing Loss, Sensorineural

Summary: the standard of care treatment of sudden hearing loss uses a type of steroid called glucocorticoid. examples of glucocorticoids are prednisone, methylprednisolone and dexamethasone. not everybody recovers hearing with glucocorticoid treatment. fludrocortisone is a different type of steroid called mineralocorticoid. unlike glucocorticoids, which work by reducing inflammation, mineralocorticoids work by changing salt and fluid balance. in animal studies, fludrocortisone is at least as effective as glucocorticoid in preserving hearing. fludrocortisone is not approved for the treatment of sudden hearing loss. the purpose of this study is to test whether fludrocortisone can treat sudden hearing loss.


Eligibility criteria:
inclusion criteria: * age 18 or older * idiopathic sudden sensorineural hearing loss within 3 months * failure to recover hearing with glucocorticoid treatment or inability to tolerate glucocorticoid exclusion criteria: * other diagnosis for the sudden hearing loss * concurrent systemic use of another steroid * hypersensitivity to fludrocortisone * systemic fungal infection * hypertension requiring two or more medications * pitting edema * cardiomegaly * congestive heart failure * electrolyte abnormality * concurrent use of barbiturates, phenytoin, fosphenytoin, rifampin, or rifapentine

Keywords: sudden sensorineural hearing loss fludrocortisone mineralocorticoid steroid
effects of warm up in athletes with previous hamstring injury

Conditions: Previous Hamstring Injury

Summary: the objectives of this study is to determine the immediate and 10 minutes follow-up effects of a warm-up based on a continous run on a treadmill or the application of a hot-pack in athletes with previous hamstring injury. the investigators have as an hypothesis that the subjects, after one of this interventions show statistically significant improvements in the measurements of pain, flexibility, proprioception and postural control


Eligibility criteria:
inclusion criteria: * to be 18-27 years old * to do sports as a minimum of 5 hours per week. * to have done sport in the last 2 years * have a hamstring flexibility of ≤80º on kendall test * diagnosed hamstring injury the last year exclusion criteria: * to take drugs that alter the motor o postural control * to do a program of stretching of the hamstring * to have lumbar pain * recent abdominal or spinal surgery intervention

Keywords: thermotherapy warm-up extensibility pain athletes