Kornimate/medical-research-clean huggingface dataset:
gene abnormalities and prognosis in diffuse large b-cell lymphoma

Conditions: Diffuse Large B Cell Lymphoma, Gene Mutation

Summary: to detect the translocation of c-myc, bcl-2 and bcl-6 by fish and 481 gene mutation by next generation sequencing and analyze the relationship between this gene abnormalities and the efficacy and prognosis in diffuse large b cell lymphoma.

this is one arm, single center non-intervention study. new diagnosed diffuse large b cell lymphoma patients were enrolled to detect the translocation of c-myc, bcl-2 and bcl-6 by fish and 481 gene mutation by next generation sequencing, then patients received standard treatment with r-chop, r2chop and da-epoch by investigate's choice according to the patients pathological characteristics. the basic characteristics and treatment response and progression-free survival and overall survival were collected and analyzed with the gene abnormalities. a total of 100 diffuse large b cell lymphoma patients will enrolled in one year and will finish after 3 years.

Eligibility criteria:
inclusion criteria: * ecog ps 0-2; * histological diagnosed diffuse large b cell lymphoma; * normal hematological, hepatal, renal function; * normal heart function with lvef ≥ 50%; exclusion criteria: * diagnosed as a malignant tumor other than lymphoma or receiving treatment, except for the following conditions: ①have received treatment for the purpose of curing, and no malignant tumor with known active disease occurred ≥5 years before enrollment; ②skin basal cell carcinoma (except melanoma) that has received adequate treatment and has no signs of disease; ③ carcinoma in situ of the cervix that has received adequate treatment and has no signs of disease. * heart disease with clinical significance, including unstable angina pectoris, acute myocardial infarction within 6 months before screening. * congestive heart failure (nyha) heart function is graded in grade iii or iv (annex 3) * severe arrhythmia requiring treatment. * patients with active hepatitis b and hiv infection. * women who are pregnant or breastfeeding * patients who have received organ transplants in the past * patients with severe active infection * have a history of severe neurological or psychiatric diseases, including dementia or epilepsy
whey protein effect on glycaemic and appetite responses in t2d

Conditions: Type II Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases

Summary: the current study will investigate the effect if whey protein on postprandial glycaemia and appetite in type ii diabetics, assessing incretin (glp-1, gip), insulin, and appetite control (leptin, pyy3-36) hormone responses.

whey protein accounts of \~20% of whole milk protein. ingestion of whey protein at meal times generates insulinotrophic/β-cell stimulation via amino acid absorption and the bioactive peptides generated during gastrointestinal digestion, resulting in attenuation of postprandial blood glucose. the bioactive peptides stimulate the release of incretin hormone, glp-1, and inhibit dpp-iv activity potentially decreasing the rate of glp-1 degradation. the current study will employ a randomised, double-blind, counter-balanced, cross-over design, whereby participants will each complete three trials; a) whey protein, b) hydrolysed protein, and c) placebo intervention. hydrolysed protein provides amino acid content, without bioactive peptides associated with incretin release, therefore, demonstrating insulinotrophic properties, only. many studies within the literature are limited for practical reasons, such as investigating high dosages (30-50 g) of whey protein, or high glycaemic index meal types which would be unlikely to form part of habitual dietary activity of type ii diabetics. therefore, the current study will objectively measure postprandial glycaemic and appetite responses following the ingestion of whey/hydrolysed protein, whilst ensuring ecological validity, dosages (18 g) and test meals applicable to everyday life, and true clinical utility for managing type-ii diabetes by integrating interventions into the habitual lives of type-ii diabetic individuals.

Eligibility criteria:
inclusion criteria: * type ii diabetic males aged 18-65 years old. * treated with metformin, or diet and lifestyle modification, only. * bmi \< 40 kg/m2. * stable physical activity pattern during the three months immediately preceding study. exclusion criteria: * not treated with insulin. * no metabolic disease other than diabetes.

Keywords: whey protein postprandial glycaemia appetite response
the effect of functional electrical stimulation

Conditions: Rupture of Anterior Cruciate Ligament

Summary: the purpose of this study is to examine the short term effect of functional electrical stimulation treatment versus neuro-muscular electrical stimulation on gait quality for patient after anterior cruciate ligament reconstruction.

background: quadriceps weakness is common following anterior cruciate ligament (acl) reconstruction. the inadequate quadriceps strength contributes to altered gait patterns following acl reconstruction. neuromuscular electrical stimulation (nmes) has been shown to reduce quadriceps atrophy post-acl reconstruction. however, the effect of functional electrical stimulation (fes), a modulation of nmes which enables quadriceps stimulation synchronized with gait, has not been tested. objective: the aim of this study is to evaluate the effectiveness of fes to improve the gait pattern of patients post acl reconstruction. methods: fifty six individuals post-acl reconstruction will be randomly placed into fes or nmes treatment group. all patients will receive a standard exercise program three sessions weekly. in addition, each group will receive a different electrical stimulation treatment: neuromuscular electrical stimulation (nmes) or functional electrical stimulation (fes). outcome measures will include spatiotemporal gait measures (e.g., gait speed, single limb support, and asymmetry index), as well as isometric quadriceps strength. measures will be taken a week before the surgery, a week after it, and one month from the beginning of rehabilitation. strength and gait pattern will be measured. isometric quadriceps strength will measured using the biodex isokinetic system, and gait analysis will be carried out through the spatio-temporal optogait system.

Eligibility criteria:
* inclusion criteria: * intended patients for acl reconstruction procedure * age 18-30 * committed for three sessions per week for 4 weeks * exclusion criteria: * previous surgery at the same knee * chronic knee swelling * knee injury * history of recurrent ankle sprains, achilles tendinopathy, or lower limb

Keywords: anterior cruciate ligament reconstruction functional electrical stimulation gait analysis physical therapy
the effect of reminiscence therapy in elderly

Conditions: Age-related Cognitive Decline

Summary: in this study titled "psychological well-being and awareness in the elderly: the effect of reminiscence therapy", patients will be randomly divided into two groups as experimental and control groups. no intervention will be made to the patients in the control group. reminiscence therapy will be applied to the patients in the experimental group. participants will be asked to fill out the scale forms after accepting to participate in the study and obtaining their consent. in addition, after the reminiscence therapy is completed, the experimental and control groups will be asked to fill out the post-test forms. the following questions will be answered in the study; * does reminiscence therapy affect the psychological well-being levels of the elderly? * does reminiscence therapy affect the awareness levels of the elderly?

with the aging society in the world and in our country, there is a great need for the development of nursing interventions that will improve and sustain the health and quality of life of the elderly, who are increasingly included in the service area of nurses. it is very important for nurses to perform non-pharmacological practices, which are among their independent functions, not only for the patient but also for their own professional satisfaction. in these services, complementary therapies related to strengthening the personal resources of elderly individuals and ensuring their correct use are important. therefore, this study aimed to determine the effect of reminiscence therapy applied to elderly individuals on their psychological well-being and awareness levels. in this study titled "psychological well-being and awareness in the elderly: the effect of reminiscence therapy", patients will be randomly divided into two groups as experimental and control groups. no intervention will be made to the patients in the control group. reminiscence therapy will be applied to the patients in the experimental group. participants will be asked to fill out the scale forms after accepting to participate in the study and obtaining their consent. in addition, after the end of the reminiscence therapy, the experimental and control groups will be asked to fill out the final test forms. the following questions will be answered in the research; * does reminiscence therapy affect the psychological well-being levels of the elderly? * does reminiscence therapy affect the awareness levels of the elderly?

Eligibility criteria:
inclusion criteria: * being over 65 years old * not having any serious psychiatric disorders * not having any diseases such as dementia etc. exclusion criteria: * having a serious psychiatric disorder * not being able to attend sessions during the research process
checkpoint inhibitors in patients with cancer and underlying autoimmune disease

Conditions: Autoimmune Diseases; Checkpoint Inhibitor; Immunotherapy

Summary: patients with cancer and concurrent autoimmune diseases (aid) have been universally excluded from clinical trials evaluating immunotherapy. data on the safety and efficacy of checkpoint inhibitors in patients with underlying aid is limited. the investigators performed a retrospective multicenter review of medical records of patients with diverse tumor types and underlying aid who received checkpoint inhibitors at departments of oncology, affiliated with the hellenic cooperative oncology group (hecog). the primary endpoint was progression-free survival (pfs).


Eligibility criteria:
inclusion criteria: * 18 years or older * patients with cancer * patients with autoimmune disease * treated at hecog-affiliated departments of oncology * early-stage or metastatic exclusion criteria: * diagnosis of the autoimmune disease after initiation of immunotherapy
mechanical ventilation weaning protocol in the coronary care unit

Conditions: Mechanical Ventilation; Cardiomyopathy

Summary: the following objectives were used for comparison: 1) primary objective: reintubation rate during hospitalization; 2) secondary objectives: length of hospitalization at the coronary care unit; time from intubation to start of weaning; time from start of weaning to extubation; time from sbt and extubation; presence of respiratory infection in patients requiring reintubation; mortality of patients requiring reintubation.

once the cause leading to the need of mv was resolved, patients from both groups underwent a daily clinical evaluation in the mornings, to determine whether they were ready for mechanical ventilation weaning, according to the following clinical sbt criteria: 1) cause of mv: resolution of the cause and abnormalities leading to mv; 2) neurological stability: patient awake, without or with minimal infusion of sedatives/narcotics, with effective cough and glasgow scale ≥ 9; 3) cardiovascular stability: mean blood pressure (mbp) ≥ 60 mm hg, without vasopressors or with low vasopressor doses, heart rate (hr) ≤ 140 / min, hemoglobin (hb) ≥ 8,0 - 10,0 g/l, partial arterial oxygen pressure (pao2) ≥ 60 mm hg with fraction of inhaled oxygen (fio2) ≤ 0.4, oxygenation index (pao2 / fio2) ≥ 150 - 300 without significant respiratory acidosis; 4) metabolic stability: temperature \< 37.8° c (armpit) and lack of hydroelectrolytic disorders.

Eligibility criteria:
inclusion criteria: * patients hospitalized at the ccu with mv for over 24 hours; * age over 18 years; * both genders; * patients capable of spontaneous ventilation; * patients with indication for mv weaning. exclusion criteria: * conditions and/or circumstances that might result in difficulty to understand the informed consent (psychiatric disorder, alcohol or drug addiction, mental disability); * patient denies to sign the informed consent; * end-stage diseases and * dependence on mechanical ventilation.

Keywords: cardiology mechanical ventilation intensive care
fractures in the elderly population of el salvador at hospital zacamil: exploring knowledge, causes, risk factors, and outcomes

Conditions: Osteoporosis; Fractures in the Elderly

Summary: as the population's life expectancy increases, fractures among the elderly in el salvador are also increasing. there is currently limited data specific to the incidence and cause of fractures in the elderly within developing countries, such as el salvador. the problem of inadequate knowledge pertaining to bone health and osteoporosis among the elderly is contributing to this aging population's health issues. the purpose of this study is to investigate the incidence, prevalence, and risk factors effecting elderly patients admitted for fractures at the hospital zacamil in san salvador, el salvador. the study will also assess the current knowledge in two distinct populations on bone health and osteoporosis. the first population will be the patients over the age of 45 that present to hospital zacamil with acute fractures and are consulted by the department of orthopedics. the second population will consist of students at the evangelical university over the age of 18 in non-medial track studies. all individuals will have to accept the invitation to participate in the study. in addition, educational materials will be developed on the prevention of fractures for medical professionals and for the elderly in el salvador. the study objectives will determine incidence and prevalence of elderly fractures of patients over the age of 45 at hospital zacamil. secondly, the study will look at demographic information, prevalent causes of fractures, treatment of the fractures, morbidity and mortality, and any complications that may arise in the fracture patients prior to their discharge from the hospital. thirdly, the study will seek out the current level of knowledge on bone health, osteoporosis, and fracture prevention in the young, educated salvadorians and patients over the age of 45 at hospital zacamil. fourthly, the study will address the benefits of the information gained by use of educational materials with the patients and doctors of el salvador. hypothesis one: fractures of the elderly at hospital zacamil are significantly associated with occurring at the hip, wrist, and vertebra in comparison to other fracture locations.


Eligibility criteria:
inclusion criteria: * for the student population they must be over the age of 18 and a student in non-medical track studies. * for the patient population they must be over the age of 45 and present to hospital zacamil with an acute fracture. exclusion criteria: * not accepting the invitation to participate.
comparison of the performance and safety of t2769 versus hylo-forte® in the treatment of moderate to severe dry eye syndrome.

Conditions: Dry Eye Syndrome

Summary: the objective is to demonstrate the non-inferiority of t2769 compared to hylo-forte® in terms of the change from baseline (d1) in total ocular surface staining score assessed on oxford 0-15 scale, in the study eye at the d36 visit. the investigation is defined as a post-market stage. the clinical investigation design is confirmatory.


Eligibility criteria:
main inclusion criteria (at screening visit): * informed consent signed and dated (obtained prior to initiating any procedures). * patient aged ≥18 years old. * persistence of dry eye syndrome, despite artificial tears use in the previous month prior to the screening visit main exclusion criteria (at both screening and randomisation visits): * far best-corrected visual acuity (bcva) ≥+0.7 logmar (e.g., ≤0.2 in decimal value or ≤20/100 snellen equivalent or ≤50 letters early treatment diabetic retinopathy study (etdrs)). * patient with previous or current ophthalmic condition
mindfulness for osteoarthritis-related knee pain

Conditions: Osteoarthritis; Chronic Pain

Summary: the purpose of this project is to investigate the feasibility and acceptability of a mindfulness based intervention for people who are attending secondary care with osteoarthritis (oa)-related knee pain.

this study will explore the acceptability of a novel intervention (an 8-week programme of mindfulness training) for people with osteoarthritis(oa)-related knee pain. mindfulness interventions provide intensive training in mindfulness meditation and its applications for coping with stress, illness and pain in day to day life. the aim of the intervention is not reduce the severity of pain per se, but to change how an individual responds and copes with pain. if effective, patients may report improvements in pain, sleep, quality of life and their ability to cope with pain in daily life. before carrying out a study to determine if such an intervention is effective, it is important to explore whether it is acceptable to patients. treatments for oa knee are usually targeted at the painful joint e.g medication, injections, physiotherapy, surgery and ultimately total knee replacement (tkr), so some patients may not expect a programme based on meditation practice to help. the investigators will recruit two groups of patients with oa-related knee pain from hospital clinics, (i) those with moderate-severe knee pain who have not yet had a tkr and (ii) those who have had a tkr who have persistent pain after one-year. all participants will complete baseline assessments before commencing an eight-week group based programme of mindfulness training, delivered by an nhs physiotherapist who is also a trained mindfulness teacher. participants will have daily meditation practices to carry out at home. follow-up questionnaires will be repeated after the intervention and again at 6 months. after the intervention, the investigators will conduct group discussions with some of the participants to explore their expectations and experiences of the intervention and the study. participants will be in the study for approximately 8 months (from time of recruitment) and the study will last 12 months.

Eligibility criteria:
inclusion criteria: * adults over 18 years, there is no upper age limit. * osteoarthritis of the knee (defined as joint space narrowing and osteophytes in 1 or more compartment) and moderate to severe knee pain (defined as 40-80mm on a 100mm visual analogue scale). or * persistent moderate to severe knee pain (40 - 80mm on a 100mm visual analogue scale), one year following total knee replacement exclusion criteria: * people who have previously participated in a 8 week mindfulness course * terminal illness and other conditions leading to incapacity to participate in the study * acute knee injury, knee joint surgery or steroid injection to the knee within previous 3 months or currently on a waiting list for knee joint surgery * inflammatory arthritis (eg rheumatoid arthritis or psoriatic arthritis) * patients who are unable to provide informed consent * patients who are unable to communicate in english, as the intervention is delivered in english
a study to evaluate the safety and efficacy of topically applied tv-45070 (ointment) in participants with primary osteoarthritis (oa) affecting a single knee

Conditions: Osteoarthritis of the Knee

Summary: the primary purpose of the study is to evaluate the change from baseline after 4 weeks of topical administration of tv-45070 (4% and 8% ointment) compared with placebo for the relief of symptoms of primary oa affecting a single knee


Eligibility criteria:
inclusion criteria: * patient is between 40 and 85 years of age, patient has primary oa in a single knee (target knee) confirmed by american college of rheumatology criteria. * for patients taking non-steroidal anti-inflammatory drugs (nsaids) or other analgesics at the time of the screening visit, * patient has visual analog scale (vas) pain scores with acceptable ranges as determined by the investigator during screening * except for oa, patient is judged by the investigator to be medically healthy and able to participate in the study. * other criteria apply, please contact the investigator for additional information exclusion criteria: * patient has secondary or inflammatory arthritis of the knee such as psoriasis, rheumatoid arthritis (ra), gout, other primary bone disease, or acute trauma. * patient has symptomatic chondrocalcinosis * patient has a history of fibromyalgia. * patient has any painful or disabling conditions that in the opinion of the investigator may confound assessment of pain scoring. * patient has uncontrolled cardiac, renal, hepatic or other systemic disorders that in the opinion of the investigator may jeopardize the patient. * patient has significant edema or skin disorder (including sores, rashes, or ulcers) at the target knee and surrounding area. * patient has a history of total or partial knee replacement in either leg. * patient had a major reconstructive knee surgery or arthroscopy of the target knee within 6 months before the screening visit. * patient is unable or unwilling to discontinue opioid and/or other prescription analgesics for control of oa pain. * patient is intolerant to study drug, its excipients, and/or acetaminophen. * patient uses any over the counter oral medications such as glucosamine or chondroitin sulfate products, unless the patient has been receiving the medication for ≥3 months at the time of the screening visit and maintains the medication as stable therapy for the duration of the study. * other criteria apply, please contact the investigator for additional information

Keywords: osteoarthritis oa arthritis pain
how to perform safely cholecystectomy for acute cholecystitis

Conditions: Cholecystectomy

Summary: the aim of this manuscript is to illustrate a new method permitting safe cholecystectomy in terms of complications with respect to the common bile duct (cbd). the core of this new technique is identification of the continuity of the cystic duct with the infundibulum. the cystic duct can be identified between the inner gallbladder wall and inflamed outer wall. in the last 2 years, 3 patients have been treated with the reported technique without complications. among the various cholecystectomy procedures, this is a new approach that ensures the safety of the structures of calot's triangle while providing the advantages gained from total removal of the gallbladder.


Eligibility criteria:
inclusion criteria: * stage ii acute cholecystitis according to the tokyo guidelines * symptom onset exclusion criteria: - stage i cholecystectomy

Keywords: acute cholecystitis cholecystectomy cystic duct
trabeculectomy versus canaloplasty

Conditions: Glaucoma; Canaloplasty; Trabeculectomy

Summary: study aims for comparison of trabeculectomy and canaloplasty, in order to find out if one operation is superior to the other. both procedures are performed in patients with medically uncontrolled open-angle glaucoma. canaloplasty is a recently newly introduced procedure, which showed encouraging results without antimetabolite usage intra- and postoperatively. purpose of the study is to compare both surgeries concerning success rate, intraocular pressure, medication and complications. so far there is no comparison of the standard procedure trabeculectomy and the new approach, canaloplasty available.


Eligibility criteria:
inclusion criteria:1. diagnosed primary or secondary open-angle glaucoma 2. iop \> 16 mmhg (\ 21 mmhg 4. no prior glaucoma surgery (once laser trabeculoplasty or cyclophotocoagulation) allowed exclusion criteria: 1. angle closure glaucoma 2. congenital glaucoma 3. combined procedures (glaucoma and cataract)

Keywords: trabeculectomy, canaloplasty, glaucoma surgery non-penetrating surgery