Kornimate/medical-research-clean huggingface dataset:
efficacy and safety of hqgzwwt patients with rheumatoid arthritis

Conditions: Huang Qi Gui Zhi Wu Wu Granule; Rheumatoid Arthritis

Summary: rheumatoid arthritis (ra) is a chronic autoimmune disease characterized by swelling, pain, and synovial damage. effective methods lack in the treatment of ra. a traditional prescription in use for thousands of years in china, huang qi gui zhi wu wu tang(hqgzwwt)granule is still chosen to relive pain and prevent joint malformation in ra patients. however, no evidence-based medical research has been organized to assess the effectiveness and safety of hqgzwwt granules for ra.

investigators will conduct a multicenter, randomized, double-blind, placebo-controlled clinical trial to determine whether hqgzwwt granules can relieve pain and protect joints. investigators will randomly divide 120 patients with active arthritis for 3 months. main measurements include ratio of 50 of acr (american college of rheumatology), change of das (28) from baseline to 3 months, and sharp scores of van der heijde from baseline to 12 months. secondarymeasurementsincludeacr20, acr70, health assessment questionnaire-disability index (haq-di), arthritis pain score, and patient global assessment of arthritis. the time points are set as baseline, 2 weeks, 1 month, 2 months, 3 months, 6 months and 12 months. in addition, the rate of change (score) in the acr50 and das28 from the baseline to 2-week, 1-month, 2-month, 6-month, and 12-month follow-up are also the secondary outcome measures.

Eligibility criteria:
inclusion criteria: * adults with rheumatoid arthritis (score more then 5 of acr (american college of rheumatology) /eular (european league against rheumatism), 2009 ) * moderate-to-severe disease activity (disease activity score for 28-joint counts (das28) of more than 3.2 * an onset of symptoms within 12 months before enrollment, no prior exposure to more than 10mg oral glucocorticoids or biologic agents * paid employment or unpaid but measurable work (e.g. caring for a family and home) exclusion criteria: * combined with other disease such as adjuvant arthritis, lupus arthritis, osteoarthritis and et al. * abnormal liver and my kidney function * pregnancy or have a plan of pregnancy,breast feeding women * severe chronic or acute disease interfering with therapy attendance * alcohol or substance abuse
safety and immunogenicity of v116 in adults living with human immunodeficiency virus (hiv) (v116-007, stride-7)

Conditions: Pneumococcal Disease

Summary: this study will evaluate the safety, tolerability, and immunogenicity of a pneumococcal 21-valent conjugate vaccine (v116) in persons living with human immunodeficiency virus (hiv), for the prevention of pneumococcal disease caused by the serotypes in the vaccine.


Eligibility criteria:
inclusion criteria: * is infected with hiv * is receiving combination anti-retroviral therapy (art) for ≥6 weeks before study entry with no intended changes to combination art therapy for 3 months after randomization. * is vaccine-naïve exclusion criteria: * has a history of opportunistic infections ≤12 months before the first vaccination * has a history of noninfectious acquired immune deficiency syndrome-related illness * has a history of active hepatitis * has a history of invasive pneumococcal disease (ipd) or other culture-positive pneumococcal disease ≤3 years before visit 2 (day 1) * has a known hypersensitivity to any component of v116, pcv15, or ppsv23, including diphtheria toxoid * has a known or suspected congenital immunodeficiency, functional or anatomic asplenia, or history of autoimmune disease * has a coagulation disorder contraindicating intramuscular vaccinations. * has a recent illness with fever * has a known cancer malignancy that is progressing or has required active treatment \<3 years before enrollment * had prior administration of pcv15 or pcv20. * is expected to receive any pneumococcal vaccine during the study outside of the protocol * has received systemic corticosteroids for ≥14 consecutive days and has not completed treatment ≥14 days before receipt of study vaccine * is currently receiving immunosuppressive therapy, including chemotherapeutic agents or other immunotherapies/immunomodulators used to treat cancer or other conditions, and interventions associated with organ or bone marrow transplantation, or autoimmune disease * has received any non-live vaccine ≤14 days before receipt of any study vaccine or is scheduled to receive any non-live vaccine ≤30 days after receipt of any study vaccine * has received any live virus vaccine ≤30 days before receipt of any study vaccine or is scheduled to receive any live virus vaccine ≤30 days after receipt of any study vaccine * has received a blood transfusion or blood products, including immunoglobulins ≤6 months before receipt of study vaccine or is scheduled to receive a blood transfusion or blood product ≤30 days after receipt of study vaccine * is currently participating in or has participated in an interventional clinical study with an investigational compound or device within 2 months of participating in this current study.
don't go there: a geospatial mhealth app for gambling disorder

Conditions: Gambling Disorder

Summary: the goal of this project is to develop and to test the efficacy of a novel mhealth app for gambling disorder. the app capitalizes on smartphones' global positioning software (gps) that recognizes a user's location to within 15 feet. users will receive an alert of this go near a gambling venue. the project will conduct a 12-week pilot randomized clinical trial to test the short-term efficacy of the app with gambling disorder individuals.


Eligibility criteria:
inclusion criteria: * currently meets dsm-5 criteria for gambling disorder * at least 4 non-online gambling episodes in past 60 days * wagering at least $100 total over past 60 days * willingness to accept random assignment * english speaking * android phone user exclusion criteria: * age \<18 years old * severely disruptive behavior * serious uncontrolled psychiatric behavior that requires acute psychiatric care * decline permission to collect zero permission data from smartphone.

Keywords: mhealth app
xience/promus for long coronary lesion registry

Conditions: Long Coronary Artery Disease

Summary: the utilization of everolimus-eluting coronary stents in a coronary artery diseases is effective in reducing both repeat revascularization and major adverse cardiac events within two year follow-up. to evaluate the procedural, short and long term clinical outcomes of multiple everolimus-eluting coronary stent implantation in long (\>30mm) coronary lesions.


Eligibility criteria:
inclusion criteria: 1. age ≥20 years and are able to undergo cabg 2. females who are not pregnant 3. patients who present with angina symptoms or myocardial ischemia 4. patients available for post-procedural observation and coronary angiography at 24 months 5. patients who have signed patient informed consent 6. lesion length is more than 30mm 7. de novo lesion or non-stented restenosed lesion exclusion criteria: 1. patients contraindicated for antiplatelet therapy or anticoagulant therapy 2. patients with significant allergic reaction to contrast medium 3. chronic total occlusion 4. lesion with timi0 5. patients with chronic renal failure (scr\>3.0mg/dl) -
correlation between root resorption and dentin sialoprotein upon application of different orthodontic forces.

Conditions: Root Resorption

Summary: since root resorption is a frequent consequence of orthodontic treatment, dsp are non-collagenous dentin-specific matrix proteins postulated to be involved in the mineralization of pre-dentin into dentin. calculating the amount of dsp -dentine sialo protein- produced upon root resorption might be an indicative biological marker for root resorption

histological and radiographic observations have shown that root resorption is a frequent consequence of orthodontic treatment (reitan, 1974; rygh, 1977; harry and sims, 1982). in most patients this resorption is minor and of no importance. a few teeth however exhibit severe resorption. in a study by goldson and henrikson (1975) it was found that 6 per cent of 924 teeth were resorped more than 2 mm after treatment with a begg appliance and malmgren et al. ( 1982) found a similar degree of root resorption in 10 percent of 264 incisors treated with an edgewise appliance and in 5 percent of 176 incisors treated with a begg appliance(1). root resorption resulting from undesirable orthodontic force is an unwanted sequele , that fears all orthodontists including their experts as well(2). dsp are non-collagenous dentin-specific matrix proteins postulated to be involved in the mineralization of pre-dentin into dentin (3,4) .dentin undergoes continuous deposition throughout life as a secondary dentin only on the pulpal surface. therefore, these proteins are not routinely released into the surrounding space as dentin does not undergo the process of remodeling as in bone. it is only in the presence of active external root resorption that these proteins could be freed into the periodontal ligament space(5). since periapical -intraoral- radiograph gives a two dimensional information, which detect root resorption after 60- 70% of the mineralized tissue is lost. (6) so, it's not sensitive in detecting early root resorption so in this study the investigators introduce the biological marker dsp to monitor root resorption from its onset by collecting samples from the gcf -gingival crevicular fluid- for its detection. calculating the amount of dsp -dentine sialo protein- produced upon root resorption might be an indicative biological marker for root resorption.

Eligibility criteria:
inclusion criteria: * adolescent female patients age ranging from 15- 18 yrs, with the full set of the permanent dentition. * no previous orthodontic treatment. * class i crowding or class ii malocclusion whose treatment requires extraction of first maxillary premolars. * adequate oral hygiene. exclusion criteria: * systematic diseases. * bad oral hygiene. * missing permanent teeth (except for third molars). * uncontrolled pathological conditions that may contra-indicate immediate orthodontic treatment (caries, gingivitis, periodontitis).
biomarker analyses in hepatocellular carcinoma (hcc) patients treated with therasphere®

Conditions: Hepatocellular Carcinoma

Summary: to analyze specific angiogenic, inflammatory and immune profiles in hepatocellular carcinoma patients who undergo radioembolization.

patients who have planned lobar radioembolization (therasphere (ts)) and consent to this study will have peripheral blood samples collected pre-ts, post-ts, 4 hours post-ts, 24 hours post-ts, 3 days post-ts, 7 days post-ts and 30 days post-ts to analyze specific angiogenic, inflammatory and immune profiles.

Eligibility criteria:
inclusion criteria: * must have the diagnosis of hcc (biopsy or imaging criteria) * must have planned lobar therasphere treatment * must be able to give consent * must have an ecog (eastern cooperative oncology group) performance status of ≤ 2 * must have a life expectancy of ≥ 3 months * women must not be pregnant with an acceptable contraception in premenopausal women * must be \> 4 weeks since prior radiation * must be \> 2 weeks since liver surgery * must be ≥ 2 weeks post radiosensitizing chemotherapy or \> 6 weeks since prior bcnu (carmustine) or mitomycin-c exclusion criteria: * patients are excluded if they do not meet the inclusion criteria

Keywords: radioembolization y90 therasphere hcc biomarker prognostic factor angiogenesis inflammatory liver
current situation and analysis of icu management for severe trauma patients in china

Conditions: ICU; Trauma Injury; ICU Acquired Weakness

Summary: over the past 10 years, there has not been a consensus on icu nursing management based on the concept of injury control. case management for patients with serious trauma continues to be initiated in general services and after discharge.there is no critical care unit case management strategy for the high-risk population following acute intake. consequently, there is an urgent need to develop and enhance icu nursing best practice after injury control.


Eligibility criteria:
inclusion criteria: * registered nurses, doctors, and rehabilitation technicians on the job; * formally hired, and working in icu for more than 6 months, with icu patient management experience; * voluntary participation in this survey. exclusion criteria: * retirees, interns/nurses/rehabilitation technicians, staff on leave, regular training doctors, and departmental nurses; * those who are unwilling to participate in this survey.
teledentistry mobile photos versus conventional clinical examination for dental caries diagnosis

Conditions: Dental Caries

Summary: teledentistry is an intervention that can boost chances for the new primary healthcare paradigm, bringing service delivery and accessibility to new levels. evidence-based studies have reported that teledentistry improves access to dental care in rural, inaccessible areas to disadvantaged populations.

the advantage of choosing teledentistry as a dental caries screening tool is its viability in increasing oral health care to underserved areas, increasing equity, and reducing oral disease burdens in children. furthermore, photographic images and prints of children's carious teeth can be used to motivate parents/guardians to seek dental treatment and institute preventive care. only a teledental assistant is needed for the imaging, eliminating the need for highly skilled professional human resources. instead, dental professionals can be better utilized in dental hospitals/clinics.

Eligibility criteria:
inclusion criteria: 1. children between 6-12 years old (mixed dentition) 2. medically free from systematic conditions exclusion criteria: 1. uncooperative children 2. children with orthodontic appliances at time of treatment

Keywords: teledentistry school children
efficacy and safety study of mci-196 versus simvastatin for dyslipidaemia in chronic kidney disease (ckd) subjects on dialysis

Conditions: Chronic Kidney Disease

Summary: the primary objective of this study is to demonstrate the superiority of mci-196 over placebo and non-inferiority with simvastatin in reducing serum low-density lipoprotein (ldl)-cholesterol in subjects with chronic kidney disease stage v on dialysis. this study incorporates a washout period and two treatment periods - an active comparison phase and a placebo-controlled withdrawal phase.


Eligibility criteria:
inclusion criteria: * male or female, and is \>=18 years old * stable hemodialysis or peritoneal dialysis * subjects undergoing regular dialysis treatment * if female and of child-bearing potential, have a negative serum pregnancy test * male subjects must agree to use appropriate contraception exclusion criteria: * current clinically significant medical comorbidities, which may substantially compromise subject safety, or expose him/her to undue risk, or interfere significantly with study procedures and which, in the opinion of the investigator, makes the subject unsuitable for inclusion in the study * serum albumin level \< 30 g/l * triglycerides level \> 6.76 mmol/l (600 mg/dl) * ldl-cholesterol level \> 4.94 mmol/l (190 mg/dl) * a history of significant gastrointestinal motility problems * biliary obstruction or proven liver dysfunction * a positive test for hiv 1 and 2 antibodies * a history of substance or alcohol abuse within the last year * the subject has a history of rhabdomyolysis or myopathy * schedule to receive a kidney transplant within the next 6 months * the subject has porphyria * participation in a clinical study with any experimental medication in the last 30 days or an experimental biological product within the last 90 days prior to signing of informed consent

Keywords: chronic kidney disease dialysis dyslipidemia bile acid sequestrant
study of hemodynamic conditions measured during hepatectomy

Conditions: Liver Dysfunction; Circulatory; Change

Summary: hepatocellular insufficiency is a dreaded complication after hepatectomy, since, if it is persistent, it leads to the death of the patient in the absence of liver transplantation. the preoperative evaluation aims in particular to estimate the risk of postoperative hepatocellular insufficiency so as to minimize or contraindicate high-risk patients. it has been shown that the flow of the portal vein is correlated with liver function, especially in the living donor and after portal embolization. more recently, the study of flow rates in the portal vein and the hepatic artery after transplantation has shown a correlation with the recovery of graft function. the hypothesis is that portal and arterial flow after hepatectomy can predict postoperative hepatocellular function.

measurements of flow rates in the portal vein and the hepatic artery by different transit times are available thanks to the medistim veriqtm system that the investigators already use routinely in the context of liver transplantation when performing hepatectomies.

Eligibility criteria:
inclusion criteria: * patient 18 years or more * patient undergoing laparotomy for liver resection exclusion criteria: * patient under tutorship or curatorship * pregnant or lactating woman * difficulties in understanding french * patient operated by laparoscopy * patient having objected to the processing of his data
clinical predictors of pediatric osahs

Conditions: Pediatric Sleep Apnea

Summary: the purpose of this study is to develop adequate and satisfactory tools using reliable clinical and physical factors in predicting pediatric obstructive sleep apnea/hypopnea syndrome (osahs) and allow greater access to appropriate therapy in children.

the prevalence of osahs is estimated to be about 1% to 4% in children, however, it is frequently underdiagnosed because of the difficulties for evaluation.current diagnostic approaches are based on the patient's history, clinical presentation and physical examination, endoscopy, and radiological imaging examinations, and confirmation is made by the current gold standard of full-night polysomnography (psg). previous studies have reported the use of a clinical history, physical examination and questionnaires for predicting pediatric osahs but there were lacking of adequate and satisfactory results. despite the potential diagnostic benefits, psg for pediatric patients are not routinely used in clinical practice. therefore, to obtain a reliable, valid, and easily-performed diagnostic or screening tool for the clinical assessment of pediatric osahs is essential for the cost-effective care of these patients.

Eligibility criteria:
inclusion criteria: * children (younger than 18 years old and older than 2 years old) with symptoms of snoring and then were confirmed to having obstructive sleep apnea/hypopnea syndrome by a comprehensive polysomnography exclusion criteria: * patients with substance abuse problems or the long-term usage of medications known to affect sleep, craniofacial abnormalities or neuromuscular disorders, down syndrome, cerebral palsy, mucopolysaccharidoses, prader-willi syndrome, history of psychosis, central sleep apnea syndrome, or previous airway surgery including tonsillectomy and/or adenoidectomy were excluded from the study.

Keywords: pediatric obstructive sleep apnea/hypopnea syndrome polysomnography
influence of serum vitamin d levels on embryo morphokinetic parameters

Conditions: Infertility

Summary: the aim of this study is observing the relation between serum vitamin d levels and morphokinesis of time lapse monitored day 5 embryo in between 18 and 38 years age women undergoing controlled ovarian hyperstimulation (coh) because of unexplained or tubal factor infertility. individuals will be divided into 2 groups according to serum vitamin d levels as normal or low , and the influence of those levels in morphokinetic parameters of embryos will be identified.

up to date there are few studies questioning the serum vitamin d deficiency as a negative factor for pregnancy rates in women undergoing coh cycles and also are displaying different and inconclusive results. this dedicated negative affects may be mediated through endometrial and/or ovarial factors. in experimental animal models vitamin d receptors have been found in endometrium and ovaries and deficient levels might have been a cause of impaired folliculogenesis. in one of human study vitamin d has been suggested as a positive regulator of anti- mullerian hormone (amh) production. therefore, we aimed to clarify the affects of vitamin d on folliculogenesis, oogenesis and embryo quality in coh cycles by using time lapse monitoring.

Eligibility criteria:
inclusion criteria: * 18 years to 38 years age, 2 or less in vitro fertilization (ivf) / intracytoplasmic sperm injection (icsi) attempt history, unexplained or tubal factor infertility, serum follicle stimulating hormone (fsh) \ 6-8 exclusion criteria: * male factor infertility, presence of endometriosis or adenomyosis,diminished ovarian reserve

Keywords: vitamin d time lapse monitoring embryo
the impact of warmed carbon dioxide insufflation during colonoscopy on polyp detection

Conditions: Colonic Polyps; Colonic Neoplasms

Summary: colorectal cancer is the second most common cancer in the world and the second leading cause of cancer-related mortality. colorectal cancers arise from precursor adenomatous polyps in a well characterized adenoma to carcinoma progression. the removal of such precursor lesions reduces colorectal cancer mortality between 30 to 50%. colonoscopy is used for detection of neoplastic polyps but significant miss rates of such lesions are reported. methods to reduce spasm of the colon have been investigated to increase adenoma detection rates including the use of warm water irrigation and hyoscine butyl bromide. carbon dioxide warmed to body temperature is postulated to have spasmolytic effects. administration of warmed carbon dioxide during colonoscopy may improve polyp detection. objective: in this study, colonoscopy using warmed carbon dioxide insufflation will be compared to standard room temperature air insufflation to see if there is a greater detection of polyps per patient. methods: patients undergoing colonoscopy for screening and surveillance indications will be included and randomized to receive either room temperature room air or warmed carbon dioxide (37 degrees celsius). endoscopists and patients will be blinded to the intervention. data on indication, preparation, sedation, withdrawal time will be recorded. polyp detection rate will be the primary outcome. secondary outcomes will include adenoma detection rate and advanced lesion detection rates.

study terminated

Eligibility criteria:
inclusion criteria: -outpatients undergoing routine screening or surveillance colonoscopy for colorectal cancer and / or polyp surveillance at hotel dieu hospital exclusion criteria: * patients who have undergone colonic resections * active inflammatory bowel disease * hereditary polyposis syndromes * moderate to severe chronic obstructive pulmonary disease * obstructive sleep apnea requiring continuous positive airway pressure or biphasic positive airway pressure * neurologic diagnoses affecting ventilation

Keywords: insufflation carbon dioxide colonic polyps colonoscopy randomized controlled trial