Kornimate/medical-research-clean huggingface dataset:
use of topical solasodine of solanum melongena peel origin in the treatment of palmar arsenic keratosis

Conditions: Keratotic Nodular Size

Summary: arsenic is one of the largest mass poisonings in bangladesh. arsenic keratosis of the palm and sole is a common feature of arsenicosis. brinjal or eggplant ubiquitous vegetable found in different parts of the world, including bangladesh, scientifically known as solanum melongena. a study showed ointment containing crude extract of solanum melongena peel origin is effective in arsenic keratosis. solasodine is one of the active compounds of solanum melongena peel. in the current study, an ointment containing a single compound solasodine isolated from solanum melongena peel . the ointment made from solasodine extract was distributed among arsenic keratosis patients to see the effect.

about millions of bangladeshi people are chronically exposed to high arsenic concentrations (above 50 micrograms/liter) through contaminated drinking water and thus suffer from arsenic-related health hazards called arsenicosis. arsenic keratosis is one of the commonest skin manifestations of arsenicosis that occur in the palm and sole that is troublesome for the working people and females suffered a negative socio-economic impact. two studies were conducted in the same department where topical ointment prepared from the crude extract of s. melongena peel was found effective in arsenical keratosis. the present study was conducted to confirm the previous study and identify that solasodine isolated from s. melongena peel is responsible for the cure of the lesions of arsenical keratosis. thus, it may be possible for the chemical synthesis of solasodine, and an effective, inexpensive topical ointment can be prepared for the cure of arsenical keratosis.

Eligibility criteria:
inclusion criteria: * presence of moderate to severe palmar arsenical keratosis * drinking arsenic-contaminated water for at least six months * patient voluntarily agreed to participate exclusion criteria: * age less than 18 years or more than 60 years * pregnant and nursing mother * skin diseases like atopic dermatitis eczema and psoriasis * patient allergic to brinjal (eggplant) * patient taken any treatment of arsenicosis for the last six months
treatment with specific carbohydrate diet in children with juvenile idiopathic arthritis

Conditions: Juvenile Idiopathic Arthritis

Summary: the aim of this study is to explore if an already established diet with anti-inflammatory effect in paediatric inflammatory bowel disease would have an anti-inflammatory effect in children with jia. the diet is called specific carbohydrate diet.

children classified with jia, in a low-to-medium disease activity and without having changed dmard or bdmard in the last 12 weeks are included. only motivated children and parents can participate. before inclusion the family are informed orally about the study plan, the diet and practical issues regarding the study and they receive written information including for example a product list and a recipe booklet. a dietician and the principal investigator follows the child and parents during visits, by mail and phone. after the baseline visit, the family has two weeks to get used to the new diet. at baseline, after two, four and twelve weeks on the diet the child is examined, blood exams are performed and blood is stored at -70, fecal samples and urine is also collected. at inclusion and after four weeks saliva sample for bacteria is collected. the child fills in the child health assessment questionnaire, (chaq) for a score of the physical ability and disabkids for an overall assessment of the childs well-being.

Eligibility criteria:
inclusion criteria: * participants should fulfill criteria for jia according to the ilar criteria * participants should not be older than 16 years at onset of disease * participants should have a low-medium disease activity with an e-sr of 30 at the most and/or no more than two active joints at inclusion. * dmard and bdmard should not have been changed within the last 12 weeks before inclusion. * any gastro- intestinal complaints should be investigated before inclusion. * fecal calprotectin should be normal. * the child as well as the parents need to be motivated for the child to try a dietary intervention for at least four weeks, preferably longer. exclusion criteria: * children with the systemic category of jia. * children with an unstable inflammatory situation with \> 2 inflamed joints and/or an e-sr of more than 30.

Keywords: juvenile arthritis diet
dissecting host-microbiome modifiers of type 2 diabetes risk

Conditions: Type 2 Diabetes

Summary: it is now well documented that changes in gut microbiota composition accompany obesity and type 2 diabetes (t2d) and contribute to low-grade inflammation, insulin resistance,and glucose intolerance. it is not yet clear if t2d predisposes the intestine to allow more microbial products or possibly live bacteria to subvert the gut mucosal barrier. however, it is known that hyperglycemia during t2d induces a more permissive gut barrier allowing increased penetration of microbes and their products into the blood. an important next step is to determine which strains of bacteria promote dysbiosis, allowing bacteria or bacterial components to subvert the gut barrier and alter glucose control. it is hypothesized that gut microbes in the colon and other lower gut segments are key modulators of energy balance, glucose homeostasis and insulin sensitivity.

the gut acts as a barrier to bacteria and nutrients and participates in glucose homeostasis via endocrine actors and the gut-brain-peripheral axis. it is unclear how t2d alters microbes in upper and lower intestine of humans. studies in animals show that t2d promotes translocation of microbes to the blood and tissues to promote metabolic dysfunction. it is crucial to determine whether bacteria or their components subvert the gut barrier in human t2d, and then to identity the relevant bacterial strains in tissues that control blood glucose. the overall objective of our research program is to demonstrate that specific microbes in the gut, circulation, and key metabolic tissues are involved in the progression of t2d. we will define the microbial signatures of t2d in duodenal biopsies and stool samples by comparing t2d and non-t2d subjects.

Eligibility criteria:
inclusion criteria: * t2db de novo or non t2db patients exclusion criteria: * oral hypoglycemic agents or lipidlowering or antihypertensive drugs
a study to collect survival data on patients previously enrolled in abraxane pancreatic cancer study ca046.

Conditions: Pancreatic Cancer

Summary: a study to collect survival data on patients previously enrolled in abraxane pancreatic cancer study ca046.

a study to collect survival status of ca046 subjects who were know to be alive at the last report of vital status for ca046 - approximate timeframe - end of march, 2013. once consent is given, on a quarterly basis, information on status will be collected to include: * vital status * date of disease progression * subsequent anticancer therapy for pancreatic adenocarcinoma

Eligibility criteria:
inclusion criteria: * must have been enrolled in the ca046 study must have been living at the time of the last survival follow-up (approximate timeframe - end of march, 2013) must understand and be able to give informed consent (if a subject is deceased, proper legal consent (ie, next of kin, legal representative) will be obtained prior to collection of data) exclusion criteria: * consent refused for any reason
electrical stimulation with different currents and electromagnetic fields

Conditions: Healthy

Summary: muscle strength is the amount of force generated by muscle contraction. it could be measured with an isometric dynamometer. this is a validated tool that could be used to measure maximal voluntary isometric contraction (mvic) and maximal electrical induced contraction (meic). it is claimed that higher meic values will result in more force gained. if a current is more tolerated it will be easier to achieve better meic values. tolerance to an electrical stimulation could be measured with the visual analogue scale (vas). a ratio between normalized meic / vas is often used, implying that the current is better with a higher ratio. muscle fatigue is defined as a temporary loss or decrease in force-generating ability due to previous contractions. it is claimed that medium frequency neuromuscular electrical stimulation (nmes) generates more fatigue than low frequency currents. aussie is a medium-frequency alternating current, sinusoidal waveform, 1 khz carrier frequency. neo-russian is a medium-frequency current, rectangular biphasic symmetrical waveform, 2,5 khz carrier frequency. rectangular biphasic symmetrical (rbs) waveform is a type of low pulsed current (lpc), claimed to be better than classical russian current. purpose: as it has been claimed that lpc is better in meic and tolerance, the aim of this study is to compare it with two newer medium frequency currents in terms of meic, tolerance and fatigue. methods: thirty male subjects, right leg dominant, will receive randomly the 3 types of electrical stimulation. before that, the mvic will be measured for data normalization. the mvic and meic will be measured with an isometric dynamometer. in both measurements, subjects will be asked to perform three reps (5 sec work x 120 sec rest) and the best one will be used. whenever the third one was the best, additional measurements will be taken until a decrease in torque will be obtained to determine the maximum. to apply aussie electrical stimulation, an aussie sport (ibramed) will be used. to apply neo-russian, a neurodyn iii (ibramed) will be used. to apply rbs, a genesy (globus) will be used. the vas will be used to assess tolerance to each treatment. one week later, the subjects will receive, randomly, a fatigue protocol that consists in 21 reps (5 sec work x 5 sec rest) of electrical stimulation with the three types of current. the data will be normalized with the mvic and the reps equal or below 50 % of the first rep will be considered as a fatigue rep.


Eligibility criteria:
inclusion criteria: * healthy volunteers * male * right leg dominant * exercising regularly exclusion criteria: * history of injuries in the right leg * skin lesions * having a pacemaker * having a cardiovascular disease. * having a neurological disorder. * exercise 72 h before the procedure.

Keywords: electrical stimulation muscle strength fatigue assessments, pain electromagnetic fields physiotherapy
analgesic effect of paracetamol, paracetamol + codeine, ibuprofen and their combination

Conditions: Pain, Postoperative

Summary: the purpose of this study is to determine whether the combination of paracetamol (acetaminophen) and other nsaids with or without weak opioids can give synergistic analgesic effect.

combining paracetamol and other nsaids could give a theoretical synergistic analgesic effect according to already known or assumed mechanisms of action. synergism is defined as an additive or supra-additive effect not achieved by one of the drugs alone. such synergism is shown in clinical studies between acetaminophen and naproxen in coxarthrosis and rheumatoid arthritis. later, a significant additive effect of 100 mg diclofenac with 1 g acetaminophen was demonstrated in a dental pain model. one review article conclude that acetaminophen and nsaids may be appropriate to combine, and the combination is superior to acetaminophen, but not to nsaids alone. this view is contested by another review article which concludes that paracetamol may enhance the analgesic effect when added to an nsaid. in both reviews the authors also state that the clinical trials are too few, with different drug formulations, and different pain models not allowing definite conclusions. there seems to be a need for studies investigating the potential synergistic effects of paracetamol combined with another nsaid displaying similar pharmacokinetic characteristics. to the best of our knowledge no published study has investigated the analgesic effect of the combination of ibuprofen and paracetamol, ibuprofen and paracetamol + codeine versus placebo (i.e. negative control to adjust for possible analgesic placebo effects) and the best standard analgesic treatment (i.e. paracetamol + codeine) as a positive control group.

Eligibility criteria:
inclusion criteria: * patients of asa class i in need of surgical removal of impacted third molars and with at least moderate postoperative pain as defined by subjective score on a verbal rating scale after surgical removal of third molars. exclusion criteria: * females stating not suspected or not verified pregnancy after being questioned by investigator. * patients who have used analgesics for 3 days prior to the day of surgery. * patients with known active gastrointestinal bleeding or ulcer. * patients with any known hypersensitivity to nsaids. * patients with other drug treatment than contraceptives. * patients smoking before taking the test-drug or during the observation period. * drug addicts or rehabilitated drug addicts. * patients with surgery time exceeding 60 minutes * peroperative complications such as profuse bleeding or perforation to the maxillary sinus requiring additional drug treatment during or after the surgical removal of the third molar. * postoperative complications such as extended bleeding, nausea and regurgitation during the observation period.

Keywords: paracetamol acetaminophen ibuprofen pain postoperative pain third molar
efficacy of tomosynthesis in the birads 3 population

Conditions: Breast Cancer

Summary: there are three main objectives, centering on those patients targeted for surveillance imaging. the first objective is to compare image quality and specificity of breast tomosynthesis and conventional 2d mammography in a birads 3 diagnostic population. the second objective is to compare image quality and ability to determine post-surgical and post-radiation changes from recurrence in a post-cancer subset of a birads 3 population having undergone conservation therapy (lumpectomy with or without radiation. the final objective is to compare image quality and the ability to determine chemoresponsiveness in a post-cancer subset of a birads 3 population, who are undergoing neoadjuvant chemotherapy.


Eligibility criteria:
inclusion criteria: group 1 * female of any race and ethnicity * 35 years or older * after routine and diagnostic imaging, subject is categorized as a bi-rads 3 and will undergo study imaging within 30 days of routine or diagnostic imaging. * subject is returning for surveillance imaging after a categorization of a bi-rads 3 and will undergo study imaging within 30 days of surveillance imaging group 2 * female of any race and ethnicity * 26 years or older * subject has completed cancer treatment and is currently categorized as a bi-rads 3 for surveillance imaging * subject will undergo study imaging within 30 days of surveillance imaging group 3 * female of any race and ethnicity * 26 years or older * subject is currently undergoing cancer treatment and is currently categorized as a bi-rads 3 for surveillance imaging or * subject will undergo study imaging within 30 days of surveillance imaging exclusion criteria: * group 1, 2 and 3 * subjects unable or unwilling to participate * subjects who are unable or unwilling to tolerate compression * subjects who are pregnant or who think they may be pregnant * subjects who are breastfeeding

Keywords: breast cancer three dimensional versus two dimensional breast cancer surveillance tomosynthesis
test of a preventive effect of a deodorant device against respiratory infections

Conditions: Respiratory Infection

Summary: this study is to test whether a chlorine dioxide gas-generating device, which releases a low concentration gas of chlorine dioxide in a sustained manner, can protect against respiratory infections in elderly individuals living in nursing homes. such a device is used as a deodorant for normal domestic purposes. the investigators reasoned that the antiviral and antibacterial properties of chlorine dioxide might lead to a lowering in the incidence of respiratory infectious diseases. the study is designed as a randomized placebo-controlled double-blind crossover multicentre trial involving approximately 1500 subjects.

chlorine dioxide (clo2), which is used as household deodorant, is a volatile gas that displays very strong oxidative activity. indeed, the powerful oxidative activity of chlorine dioxide (ogata, n., biochemistry 46, 4898-4911, 2007) is responsible for its antimicrobial activity against bacteria (benarde, m. a., et al. appl. mircrobiol. 15, 257-265, 1967), fungi (morino, h., et al. yakugaku zasshi 127, 773-777, 2007) and viruses (ogata, n. and shibata, t. j. gen. virol. 89, 60-67, 2008). recently, we found that the rate of absenteeism due to illness in a school was lower in classrooms where a chlorine dioxide gas-generating device was placed than in classrooms with no such device. based upon this unexpected observation we hypothesize that chlorine dioxide gas, at a concentration low enough not to harm humans, may lower the incidence of respiratory infections by inactivating airborne microorganism within an enclosed space.

Eligibility criteria:
inclusion criteria: * those who who agrees with the aim of the study exclusion criteria: * those who do not agree with the aim of the study

Keywords: common cold influenza pneumonia
microperimetry and optical coherence tomography (oct) in idiopathic macular hole

Conditions: Macular Hole

Summary: to evaluate the correlations between anatomical and functional changes studied with microperimetry (mpm) and spectral-domain oct (sd-oct) in patients after successful repair of idiopathic macular hole (mh).


Eligibility criteria:
inclusion criteria: * closure of the hole seen on the oct at 1 year postoperative exclusion criteria: * patients with an axial length over 26 mm, diabetes, macular diseases, glaucoma, or postoperative retinal detachment were excluded
prophylactic continuous positive airway pressure (cpap) in delivery room, in the prevention of transient tachypnea of newborn (ttn): a randomized controlled trial

Conditions: Transient Tachypnea

Summary: transient tachypnea of the newborn (ttn) is a disorder of delayed clearance of lung liquid and a common cause of admission of full term infants and late pre term infants (34 to 36 weeks) to neonatal intensive care units (nicu). both late preterm gestational age at delivery, and mode of delivery are considered risk factors for ttn. the investigators hypothesize that cpap administered prophylactically in the delivery room via a t piece based infant resuscitator neopuff, to neonates at increased risk for ttn, would decrease the incidence of ttn and thus decrease the need for hospitalization in the nicu. this is a pilot study to evaluate the prophylactic administration of cpap in the delivery room towards prevention of ttn and it's effects on natriuretic peptides.the study will be conducted as a randomized control trial after obtaining informed consents from the parents of eligible infants. infants will be randomized to receive either experimental treatment (prophylactic cpap) or standardized care.


Eligibility criteria:
inclusion criteria: * babies born to mothers via elective cs: elective cs defined as planned cs in the absence of labor. * late preterm infants (34 1/7 to 36 6/7 weeks gestational age) exclusion criteria: * presence of any of the risk factors for neonatal sepsis such as prolonged rupture of membranes for ≥18 hours (prom), maternal fever, maternal chorioamnionitis or positive maternal gbs colonization * need for use of ppv for perinatal depression or other indications * presence of any of the following * congenital malformations (diagnosed prenatally) * chromosomal anomalies (diagnosed prenatally) * congenital heart disease diagnosed by fetal echocardiography.

Keywords: transient tachypnea of the newborn elective cesarean section late preterm cpap delivery room
efficacy of formulated eggshell derived nano-hydroxyapatite containing toothpaste with and without addition of fluoride vs. conventional desensitizing fluoride containing toothpaste in management of dentin hypersensitivity

Conditions: Dentin Hypersensitivity; Fluoride; Nano-hydroxy Apatite

Summary: compare the effectiveness of eggshell derived nano-hydroxyapatite with and without fluoride and conventional fluoride containing tooth paste versus conventional desensitizing fluoride containing tooth paste on dentinal tubule occlusion and dentin mineral deposition.

recently advanced nanotechnology has taken a wide leap in improving the various measures in the treatment of hypersensitivity by its nanoparticles. nanoparticles can easily penetrate into dentin tubules, which could act as mineralizing agents that block fluid movement within the dentin tubules when combined with various agents. hydroxyapatite (hap) is the major inorganic component of natural teeth and bone. nano-sized particles of hydroxyapatite are similar to the apatite crystals of tooth enamel in morphology and crystal structure and has been studied as a biomimetic material for the reconstruction of tooth enamel suffering from mineral loss because of its unique potential for remineralization. nano-hydroxyapatite (n-hap) was considered a promising active ingredient used for the treatment of dh due to high biocompatibility and bioactivity. in toothpastes, hap was included in the form of nanocrystals because they dissolve easier in this form. crystals of n-hap included in dental products have a dimension of 50-1000 nm, which enables them to act like fillers. these products can penetrate and block the exposed dentinal tubules which are responsible for dh

Eligibility criteria:
inclusion criteria: * adult patients aged 18-60 * males or females. * good oral hygiene * absence of abnormal occlusion habits (e.g. bruxism, nail biting, tooth clenching and mouth breathing). * teeth with hypersensitivity, vas ≥5 * co-operative patients who show interest to participate in the study. exclusion criteria: * patients with known allergic or adverse reaction to the tested materials. * systematic disease that may affect participation. * xerostomic patients. * patients with bad oral hygiene * patients with orthodontic appliances, or bridge work that might interfere with evaluation * patients who did any periodontal surgeries within the previous 6 months. * patients with physical disabilities