Kornimate/medical-research-clean huggingface dataset:
traditional chinese medicine, western medicine and low-level light therapy（lllt） for primary dysmenorrhea（pd）

Conditions: Primary Dysmenorrhea; Traditional Chinese Medicine; Light

Summary: to observe the clinical efficacy and safety of three methods for the treatment of primary dysmenorrhea. establish an integrated biomarker index system for the evaluation of the efficacy of traditional chinese medicine, western medicine and low-level light therapy for the treatment of primary dysmenorrhea, and further explore the mechanism and therapeutic material basis of the three treatment methods for the treatment of primary dysmenorrhea

480 women clinically diagnosed of primary dysmenorrhea will be enrolled from nationwide multi-centers. blood samples were collected from 480 patients before and after treatment (1 experimental group, 3 control groups, treatment cycle of 3 menstrual cycles, follow-up cycle of 5 menstrual cycles), metabonomics study, and integration of clinical sample information (serum biochemical indicators, imaging indicators, etc.), through bioinformatics to establish a comprehensive biomarker index system for the evaluation of the efficacy of traditional chinese medicine, western medicine and low-level light therapy instrument methods for the treatment of primary dysmenorrhea and its therapeutic basis.

Eligibility criteria:
inclusion criteria: 1. female (16-35 years old); 2. regular menstruation (cycle 21-35 days, menstrual period 3-7 days); 3. be clinically diagnosed with primary dysmenorrhea; 4. be willing to participate in the whole process of the research in 5 consecutive menstrual cycles. exclusion criteria: 1. irregular menstruation affecting the treatment and efficacy judgment; 2. patients with secondary dysmenorrhea; 3. those who have used related drugs in the past 3 months; 4. abuse or dependence on substances (alcohol or medicine) in the past 3 months; heavy smokers (smokers who smoke 20 or more cigarettes per day); 5. those who have severe or unstable physical illnesses, related to liver, kidney, gastrointestinal tract, cardiovascular, respiratory, endocrine, nervous, immune or blood systems, neuropsychiatric systems and so on; 6. lactating or pregnant women, or women within 1 year after delivery; 7. those who are allergic to the test drug or light, have contraindications for marvelon and ding kun dan; 8. have a history of thromboembolic disease or a tendency to thrombosis; 9. one month before joining in this study (first interview), who participated in another clinical trial; 10. those who meet the inclusion criteria, fail to follow the doctor's advice so that we cannot judge the curative effect ,the incomplete data cannot be evaluated.

Keywords: primary dysmenorrhea traditional chinese medicine low-level light therapy
get active and eat right: moms at work

Conditions: Overweight; Obesity

Summary: the purpose of this study is to determine the effectiveness of a worksite diet and exercise program on weight loss in postpartum women.

this project is a research study investigating the effects of a worksite diet and exercise intervention on weight loss in overweight postpartum women. weight loss programs have been shown to be effective in reducing postpartum weight retention. however, high attrition rates in these studies suggest that the added responsibility of a new infant at home and returning to work may limit a woman's ability to follow a diet plan and exercise regularly. we hope that by offering a weight loss program at the workplace, we can increase participant retention and maximize weight loss in this population. our primary aim is to promote weight loss while preserving lean body mass during the 12 week intervention. secondary aims include increasing cardiovascular fitness from baseline and improving cardiovascular biomarkers, including total, ldl, and hdl cholesterol, triglycerides, glucose, insulin, and markers of inflammation and metabolism.

Eligibility criteria:
inclusion criteria: * 18 years and older, 10 to 14 weeks postpartum, university faculty, staff, and students, bmi 25-35 or at least 4.5 kilograms heavier than prepregnancy weight, english speaking exclusion criteria: * smoking, chronic disease, bmi \>35

Keywords: overweight obese postpartum weight loss inflammation obesity cardiovascular
hypertension and controlled hypotension in the elderly

Conditions: Delirium

Summary: comparision of exposed factors of preoperative hypertension and intraoperative controlled hypotension on postoperative delirium in the elderly under radical resection of head, neck and maxillofacial tumor

postoperative delirium has a higher incidence in elderly patients after general anesthesia，and it is closely related to the type of surgery, the length of surgery, and the patient's physique.because head and neck maxillofacial radical surgery requires free flap transplantation and longer duration,and hemorrhage is more when the primary focus is removed，intraoperative blood pressure reduction is needed to reduce bleeding，therefore, hypoperfusion of craniocerebral blood flow will occur.low cerebral perfusion is closely related to the occurrence of postoperative delirium.patients undergoing this type of surgery have more preoperative complications，hypertension is particularly common.therefore, this study mainly studied the correlation between the preoperative blood pressure level and the controlled hypotension level in patients with radical head and neck and maxillofacial tumors and the incidence of postoperative delirium.

Eligibility criteria:
inclusion criteria: 1. patients who underwent radical anesthesia for oral and maxillofacial malignant tumors in our hospital 2. asa grade is ⅰ-ⅱ 3. patient is older than 60 years exclusion criteria: 1. the patient has mental and mental disorders (eg schizophrenia, alzheimer's disease) 2. there was severe anemia before operation (hb\<80g/l) 3. patients had cerebral vascular complications such as cerebral infarction and lacunar infarction before operation 4. patients who do not cooperate with this trial 5. long-term use of sedative drugs or analgesics
dexmedetomidine for espb in pain management after pediatric idiopathic scoliosis surgery

Conditions: Scoliosis Idiopathic; Scoliosis; Scoliosis; Adolescence

Summary: effect of perineurial dexmedetomidine on erector spinal plane block duration for pediatric, idiopathic scoliosis surgery.

this study proposes to explore the effect of perineurial dexmedetomidine on the duration of erector spinal plane block for pediatric idiopathic scoliosis surgery. children need good analgesia after scoliosis surgery. peripheral nerve blocks have provided a safe, effective method to control early postoperative pain when symptoms are most severe. the safety of local anesthesia is essential in children due to the much lower toxicity threshold of local anesthetics. an effective adjuvant, such as dexmedetomidine, could allow for a higher dilution of local anesthetics while maintaining and enhancing their analgesic effect.

Eligibility criteria:
inclusion criteria: * children scheduled for idiopathic scoliosis surgery * age \>10 and \<18 years exclusion criteria: * age \< 10 years * age \< 18 years * infection at the site of the regional blockade * coagulation disorders * immunodeficiency * asa= or \>4 * steroid medication in regular use
treatment of postpartum hemorrhage with misoprostol: fever study

Conditions: Postpartum Hemorrhage

Summary: this study seeks to assess whether populations of women in latin america outside quito, ecuador are at increased risk for developing elevated body temperature above 40.0°c following pph treatment with 800mcg sublingual misoprostol. the study will be carried out in hospitals representative of different regions of latin america to explore environmental and genetic hypotheses related to the occurrence of misoprostol-induced fever. postpartum blood loss, pulse and blood pressure will be systematically measured for all women enrolled to explore new clinical indicators for identifying women who require clinical intervention for excessive bleeding. blood samples will be collected among women treated with misoprostol to investigate genetic factors responsible for elevated body temperature induced by misoprostol. the investigators hypothesize that rates of high fever (≥40.0°c) following misoprostol treatment (800mcg given sublingually) will be variable across settings. the investigators expect that the side effect profile following 800 mcg misoprostol given sublingually, in particular the rates of any shivering and fever ≥38.0°c, will be comparable to previous results using misoprostol for pph.


Eligibility criteria:
inclusion criteria: * able and willing to give informed consent * vaginal delivery * postpartum hemorrhage due to suspected uterine atony * able and willing to give informed consent exclusion criteria: * known allergy to misoprostol or other prostaglandins * underwent a c-section during the current delivery * unable to provide informed consent due to mental impairment, distress during labor or other reason * unwilling and/or unable to respond to brief questionnaires or have her blood drawn

Keywords: primary postpartum hemorrhage pph uterine atony high fever hyperpyrexia shock index
use of pet/mri tracer to further understanding of prostate cancer development

Conditions: Prostate Cancer; Bladder Cancer

Summary: the purpose of this study is to develop a novel technique for integrated pet/mri tracer kinetic analysis for urologic malignancy.

patients scheduled to undergo gadolinium-enhanced mri for urologic malignancy will be recruited to undergo pet/mri employing simultaneous dynamic acquisition of pet and gadolinium-chelate data sets. for initial technical development within this pilot study, analysis will be performed attempting to compute tracer delivery using inputs from an integrated mri-perfusion analysis. flow and permeability will be obtained from the mr perfusion analysis, which can be used to compute the inflow rate constant k1. k1, reflecting the transfer of contrast, will then be used to compute the metabolic uptake of fdg by the organ as well as of any visible tumors. a determination will be made whether this metabolic uptake is successfully computed for each case. if not, then acquisition and post-processing modifications will be made for subsequent cases.

Eligibility criteria:
inclusion criteria: the study population will consist of patients with known urologic cancer who are scheduled to undergo mri with gadolinium for their routine care. patients will be referred by the urology or medical oncology departments for participation in the study. subjects will be selected on the basis of their willingness and ability to participate and on their likelihood of completing the study. patients agreeing to participate will be presented with a flyer which will inform subject about the available research study and study contact information. participation is entirely voluntary, and a subject may withdraw from the study at any time. normal volunteers will be recruited accessing the existing database of normal volunteers maintained in radiology research department. exclusion criteria: normal mri exclusion criteria will apply, including those on the following list. a standard mri safety form will be used to identify potential conditions warranting exclusion. * electrical implants such as cardiac pacemakers or perfusion pumps * ferromagnetic implants such as aneurysm clips, surgical clips, prostheses, artificial heart, valves with steel parts, metal fragments, shrapnel, bullets, tattoos near the eye, or steel implants * ferromagnetic objects such as jewelry or metal clips in clothing * claustrophobia * history of seizures

Keywords: prostate cancer bladder cancer mri pet perfusion
the effect of education on drug compliance and quality of life in hepatitis b patients

Conditions: Hepatitis B, Chronic; Adherence, Medication; Quality of Life

Summary: the aim of this study is to determine the effect of the education given to patients with chb who use oral antiviral drugs on oral antiviral drug use on drug compliance and quality of life.


Eligibility criteria:
inclusion criteria: * being diagnosed with chb for at least 6 months, * to be over 18 years old, * using oral antiviral treatment for at least three months, * to be a literate person, * no malignancy other than hepatocellular carcinoma, * not having vision and hearing problems, * not having cognitive or psychiatric problems, * patients/patient relatives who can use smartphones (in order to invite the patients to the 3rd and 6th month controls and to inform and remind the experimental group about the training time, they / their relatives should have and can use a mobile phone) * volunteer to participate in the study. exclusion criteria: * •continuing to use alcohol after the first evaluation, * not willing to participate in the study, * patients with a psychiatric diagnosis, * patients who do not meet the sample inclusion criteria.

Keywords: chronic hepatitis b adherence, medication quality of life
pilot study evaluating the safety and efficacy of a new hard-on-hard total hip replacement system

Conditions: Arthritis, Degenerative

Summary: the purpose of this study is to assess the early and long term safety and efficacy of the hard-on-hard total hip replacement system (r3 odh-odh utilization) in patients with non-inflammatory arthritis.


Eligibility criteria:
inclusion criteria: * at least 21 years old * skeletally mature * requires primary, unilateral total hip arthroplasty due to degenerative join disease * preoperative harris hip score of less than or equal to 70 * meets an acceptable preoperative medical clearance and is free or treated for conditions that would pose excessive operative risk * given consent to participate in the study * able to understand the purpose of the study, his/her role, and is available for follow-up 10 year extension: * subject has completed the 2 year primary study * subject has signed an independent ethics committee (iec) approved informed consent form agreeing to participate in the extension study after the nature, scope and possible consequences of the study have been explained in an understandable form * subject is able to fully understand the purpose of the study, his/her role as a participant in the study, and plans to be available through ten years post-operative follow-up exclusion criteria: * diagnosis with high risk of total hip arthroplasty (tha) failure * requires bilateral tha * requires revision of a prior hip replacement * active infection or sepsis * history of local hip infection * known metastatic or neoplastic disease * conditions that may interfere with tha survival or outcomes * need for structural bone grafts to support the implant * contralateral lower extremity condition * has other joint replacements or plans for other joint replacements within 2 years * systemic steroid therapy within 3 months prior to surgery * life expectancy less than 2 years * intra-articular therapy within 6 months of enrollment * female of child-bearing age not using contraception * inadequate bone stock to support the device * moderate to severe renal insufficiency * emotional or neurological condition that would pre-empt ability or willingness to participate in the study * bmi \>40 * above the knee amputation of the contralateral or ipsilateral leg * known allergies to the components of the devices * entered into another investigational study * is a prisoner 10 year extension: • in the opinion of the surgeon, the subject's health, safety or well-being may be compromised or harmed by continuation in the extension phase or participation may not be in the subject's best interests.

Keywords: total hip replacement (thr) total hip arthroplasty (tha)
systematically assessing effects of colored light on humans with a multi-modal approach (substudy 1 of 7)

Conditions: Exposure to Man-made Visible Light

Summary: note: this is the first of in total 7 sub-studies related to the ethics committee of the canton of bern ref. no. kek-be 2016-00674. this sub-study includes 50 participants and 5 arms, in total 350 participants will be assessed in all 7 sub-studies. general study information: this is a randomized, cross-over, quantitative study, which investigates physiological variables, mood, and affect of healthy participants in response to colored light exposure. the participants take part in 5-8 arms and are exposed to colored light only, or are additionally asked to solve cognitive tasks during the colored light exposure. primary aim is to measure the change in several physiological variables, mood, and affect during colored light exposure of 15 or 45 minutes. the risk for the participants is negligible and comparable to the risk during daily life.


Eligibility criteria:
inclusion criteria: * normal color vision * right handed * written informed consent exclusion criteria: * smoking * any kind of diagnosed sleep disorder or neurological or psychiatric disorder in the last 3 months * acute severe traumas * chronic diseases with the necessity for medication * use of recreational drugs * regular intake of medication that would affect the outcome measures * regular excessive alcohol use (\> 18 standard units / week) * transmeridian travel in the last month (crossed \> 1 time zone border) * night shift word during the last month

Keywords: cerebral oxygen metabolism functional near-infrared spectroscopy partial pressure of carbon dioxide heart rate variability blood pressure affect mood respiration systematic randomized cross-over study systemic physiology electro-dermal activity pulse-respiratory quotient
comparative study between dexmedetomidine and fentanyl as adjuvants to bupivacaine

Conditions: Post Operative Pain

Summary: combined femoral and sciatic nerve block provides surgical anesthesia with better cardiorespiratory stability as compared to the spinal anesthesia blockade which has side effects of hypotension, bradycardia, meningitis, post dural puncture headache, hematoma, and neurological deficit

combined femoral and sciatic nerve block provides surgical anesthesia with better cardiorespiratory stability as compared to the spinal anesthesia blockade which has side effects of hypotension, bradycardia, meningitis, post dural puncture headache, hematoma, and neurological deficit, adjuvants are those drugs which, when co-administered with local anesthetic agents, may improve the speed of onset and duration of analgesia and counteract disadvantageous effects of local anesthetics. by adding these adjuvants, the dose of local anesthetics like bupivacaine can be reduced, thereby reducing its side effects like myocardial depression, hypotension, bradycardia, heart block, and ventricular arrhythmias. based on "combination wisdom", the use of adjuvants to local anesthetics has been promoted a lot .a wide variety of drugs have been used for both neuraxial and peripheral nerve blocks, and the most commonly used drug as adjuvant is the fentanyl . the addition of dexmedetomidine during us-guided combined femoral and sciatic block for below knee surgery was associated with a prolonged duration of analgesia.

Eligibility criteria:
inclusion criteria: * patients aged 18-65 years. * american society of anesthesiologists (asa) physical status i-ii, * scheduled for elective surgery below the knee. exclusion criteria: * allergies to used medications. * coagulopathy. * septic patients. * neurological disease. * respiratory or cardiac disease. * diabetes mellitus. * patients' refusal to participate.
novel biomarkers to predict outcome in clostridium difficile infection

Conditions: Clostridium Difficile Infection

Summary: acquiring diarrhoea in hospital is a serious problem and most frequently occurs when susceptible patients receive antibiotics as part of their (often life-saving) care. the commonest cause is clostridium difficile - a bacterium that normally lives in up to a third of us but causes no problems. rates of infection had been falling with increased awareness and improved hygiene but they are starting to creep up again. clostridium difficile can cause a range of disease from a short-lived mild diarrhoea to severe disease of the bowel with major effects on the whole body and even death. this study aims to identify substances in the stool and in the blood to enable doctors to predict how severe that individual's disease will be. these tests can easily be performed. if they prove accurate in identifying the subsequent severity of the patient's illness due to clostridium difficile, patients predicted to develop the worst disease can receive the most intensive treatments before they become too unwell to benefit. on the other hand, patients whose disease is predicted by these markers to run its course without causing serious consequences can be spared the side effects and risks of more intensive treatment.

clostridium difficile infection (cdi), which is often a consequence of antibiotic therapy, is the most common and one of the most serious hospital-acquired illnesses. it causes a range of intestinal upset from mild diarrhoea to a life-threatening severe colitis. the incidence, recurrence and mortality rates of cdi have increased dramatically in recent years. metronidazole is the recommended first-line antibiotic, with vancomycin and colectomy reserved for severe cases. although risk factors for developing cdi are well known, factors that predict outcome and/or recurrence of cdi are uncertain and lack specificity for intestinal inflammation. we wish to investigate if careful prospective monitoring of standard clinical and biochemical measures will be able to identify patients who will go on to fail primary treatment. if one or more of these factors proves able to predict outcome, they could ultimately be used for early escalation of therapy with the aim of reducing morbidity, mortality and length of hospital stay.

Eligibility criteria:
inclusion criteria: * test positive for cdi on stool analysis * inpatient at barts health nhs trust at time of diagnosis exclusion criteria: * nil specific

Keywords: clostridium difficile prediction treatment failure
a retrospective study of clinical, phenotypic and genetic factors of peripheral t-cell lymphomas

Conditions: Lymphoma, T-Cell, Peripheral

Summary: the purpose of this study is to establish the distribution of peripheral t-cell lymphocyte (ptcl) subtypes by re-analysis and re-classification of samples according to the 2008 world health organization (who) classification of lymphoid neoplasms.

this study is a retrospective, non-interventional and, post-authorization observational study of other designs (pas-od). this multicenter trial will be conducted in spain. retrospective review of medical records and initial tumor biopsies of participants diagnosed with ptcl in the period of 6 years between 01/01/2008 and 31/12/2013 will be performed. initial tumor biopsies and histological preparations, filed and previously anonymized, will be sent to the central laboratory for assessment.

Eligibility criteria:
inclusion criteria: * participants diagnosed with ptcl in the six years between 01/01/2008 and 31/12/2013. * availability of initial tumor biopsy diagnosis in paraffin block (node or core biopsy of 16-18mm). * ptcl subtypes permitted by who 2008 classification of lymphoid neoplasms: * natural killer/ t-lymphocytes (nk /t-cell) lymphoma extranodal nasal type * enteropathic t-cell lymphoma * hepatosplenic t-cell lymphoma * peripheral t-cell lymphoma, not otherwise specified * angioimmunoblastic t-cell lymphoma * anaplastic large cell lymphoma, anaplastic lymphoma kinase positive (alk)+ * anaplastic large cell lymphoma, alk- exclusion criteria: • participants with an unavailable history (lost, empty or not recoverable).

Keywords: drug therapy