Kornimate/medical-research-clean huggingface dataset:
a laboratory scan of patients with aortic aneurysms to igg4 levels in the blood

Conditions: IgG4-related Disease; Aortic Aneurysm

Summary: igg4 related disease is a multi-systemic fibroenophilic disease that includes a basket of recently discovered medical conditions. the properties that bind them are: lesions similar to tumors in the mixed organs, lymphoplasms filtrate enriched with plasma igg4 positive cells, storiform fibrosis, and often, but not always, a high level of igg4 in the serum. this disease has been on the rise for the past two decades and since its recognition in 2001 there has been impressive progress in understanding its various manifestations, so that today almost every body system can be involved. one of the conditions associated with this disease is oritis / periortitis and aneurysms

igg4 related disease is a multi-systemic fibroenophilic disease that includes a basket of recently discovered medical conditions. the properties that bind them are: lesions similar to tumors in the mixed organs, lymphoplasms filtrate enriched with plasma igg4 positive cells, storiform fibrosis, and often, but not always, a high level of igg4 in the serum. this disease has been on the rise for the past two decades and since its recognition in 2001 there has been impressive progress in understanding its various manifestations, so that today almost every body system can be involved. one of the conditions associated with this disease is oritis / periortitis and aneurysms it is common to divide the aortic aneurysms according to the following etiologies: 1. inflammatory-aortic aneurisms (iaa) the internal division in this category is whether igg4rd is related / not related. 2. atherosclerotic infrastructure. differences between the etiologies: iaa - greater thickness of the wall, fibrosis and adhesion to nearby retroperitone structures. also, younger age and non-specific symptoms. in addition, the laboratory findings are usually white counts and increased crp. in this context, the investigators will examine the level of igg4 in the blood of a population of patients with aortic aneurysms and try to understand the proportion of patients whose igg4 level is higher than normal and their aneurysm can be attributed to igg4 related disease. the investigator chose the blood igg4 level because it is the most important diagnostic variable for the disease (it is customary to place the incision point at \> 135mg / dl).

Eligibility criteria:
inclusion criteria: * patients after aneurysm in the aorta * men and women aged 18-100 (not including special populations) * those who are able to read understand and sign a written consent to participate in the research exclusion criteria: * any patient who does not meet the inclusion criteria
comparing the impact of rubber bands on teeth straightening with clear aligners versus traditional braces: a clinical study

Conditions: Class II Malocclusion; IMPA Angle

Summary: aim: to analyze the inclination of lower incisors in patients with class ii malocclusion treated with elastics and clear aligners compared to a group wearing the same elastics and fixed appliance. a sample of 40 patients (19m and 21f), mean age 15.4±1.8 years, was randomly divided in two groups: clear aligner group (ca), fixed appliance group (fa). the subjects were selected according to inclusion criteria: full permanent dentition (excluding third molars), class ii molar relationship (2,5-4 mm), no history of orthodontic treatment.

trial design: prospective two-arms parallel group randomized clinical trial with 1:1 allocation ratio. materials and methods: a sample of 40 patients (19m and 21f), mean age 15.4±1.8 years, was collected from the department of orthodontics at policlinico "tor vergata" of rome, and it was randomly divided in two groups: clear aligner group (ca), fixed appliance group (fa). the subjects were selected according to inclusion criteria: full permanent dentition (excluding third molars), class ii molar relationship (2,5-4 mm), no history of orthodontic treatment. results: in the short term (t1-t0=18 months), the analysis of the results showed no statistically significant changes in all evaluated parameters. therefore, there is no statistically significant change in the inclination of the lower incisors between the two groups. conclusions: the use of class ii elastics in ca group showed a better control of the lower incisors' inclination, compared to the fa group, even if the difference is not significant. trial registration: clinicaltrials.gov (registration number: ..........)

Eligibility criteria:
inclusion criteria: * full permanent dentition (excluding third molars), class ii molar relationship (2,5-4 mm), no or moderate crowding (0- 3 mm) no history of orthodontic treatment. exclusion criteria: * not completed permanent dentition, skeletal class ii or dental class ii more than 4 mm, crowding more than 3 mm, subjects already treated with iother orthodontic appliances.
signal transfer of atrial fibrillation data to guide human treatment

Conditions: Permanent Atrial Fibrillation

Summary: the purpose of the study is to gather electrophysiological data using a multi-electrode mapping catheter during a clinically indicated cardiac ablation procedure for the treatment of persistent atrial fibrillation.


Eligibility criteria:
inclusion criteria: * age 18 or above, or above legal age and willing and capable of giving informed consent specific to national law * scheduled for a clinically indicated cardiac ablation for the treatment of persistent atrial fibrillation * able to meet study requirements for follow-up visit exclusion criteria: * permanent leads or presence of prosthetic or severely stenotic tricuspid or mitral valves * active systemic infection or sepsis * echocardiographically confirmed presence of thrombus * atrial thrombus, myxoma, inter-atrial baffle patch or occluder device for those subjects in whom a transseptal approach is required * subjects who cannot be anticoagulated or infused with heparinized saline * heparin induced thrombocytopenia * hemodynamic instability or shock * atrial anatomy contradictory to catheter labeling or size indices * ef \< 35% * subjects with an active heart failure decompensation

Keywords: electrophysiological mapping multi-electrode catheter
non-inferiority of portable versus desktop spirometry

Conditions: Asthma; COPD

Summary: the investigators compared the ventilation parameters for volume and flow obtained from standard spirometry procedures from patients presently monitored and treated for asthma or chronic obstructive pulmonary disease (copd) using aiocare (healthup sp. z o.o., serial number: ms082017005412, software version: myspiroo app 1.1.14) as the tested device and spirometer usb cpfs/d (mgc diagnostics) as the reference, which required calibration prior to each session. spirometry measurements were performed on sixty-two patients (forty-four females (58±17 years old) and eighteen males (52±19 years old)) at the institute of tuberculosis and lung disease in warsaw, poland. participants were asked to perform correct spirometry examinations (which means at least three technically correct exhales and meeting repeatability criteria for fev1 and fvc) on both measuring devices with a five-minute break between devices to prevent respiratory muscle fatigue. the highest value from all acceptable spirometry results was then used for analysis. all spirometry examinations followed ers/ats standards.


Eligibility criteria:
inclusion criteria: 1. age\>18. 2. diagnosed asthma or copd 3. signed consent to participation in the research experiment. 4. ability to comply with the spirometry protocol. exclusion criteria: 1. pregnant females (based on declaration; no pregnancy tests are planned before the test). 2. recent myocardial infarction (\<30 days). 3. known thoracic, aortic or cerebral aneurysm. 4. recent stroke, eye surgery, thoracic/abdominal surgery. 5. haemoptysis. 6. recent pneumothorax. 7. uncontrolled hypertension. 8. pulmonary embolism. 9. angina. 10. chest or abdominal pain of any etiology. 11. oral or facial pain exacerbated by a mouthpiece. 12. stress incontinence. 13. dementia or state of confusion. 14, acute diarrhea

Keywords: asthma copd mobile spirometry
investigating the relationship between nocturnal glucose levels and motion during sleep

Conditions: Diabetes; Hypoglycemia; Hyperglycemia

Summary: in this study the investigators will explore whether the motion during sleep of people with diabetes changes as a function of the blood glucose levels. the motion will be assessed with a radar sensor, a thermal camera, and wrist worn smartwatches. additionally, participants will answer a short daily questionnaire. data will be collected for 10 days and analyzed at the end of the study.


Eligibility criteria:
inclusion criteria: * informed consent as documented by signature * age ≥ 18 years * patients at the outpatient clinics or from a referring diabetologist with a diagnostic cgm according to best medical practice * patients with diabetes mellitus on an insulin therapy or with non-insulin antidiabetic medication with the potential to induce hypoglycemia * hba1c value between 6% and 10% (inclusive) within 6 months prior to inclusion exclusion criteria: * wearables cannot be attached around the wrist of the patient * known allergies to components of the wearables * female subjects: pregnancy, lactation period, lack of a negative urine pregnancy test (except in case of menopause, sterilization or hysterectomy), or unwilling to use a contraception during the study (for sexually active subjects of childbearing potential) * known cardiac arrhythmia (e.g., atrial flutter or fibrillation, atrioventricular-reentry tachycardia, atrioventricular block \> grade 1) * pacemaker or icd (implantable cardioverter defibrillator) * treatment with antiarrhythmic drugs or beta-blockers * drug or alcohol abuse * inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant * physical or psychological disease likely to interfere with the normal conduct of the study and interpretation of the study results as judged by the investigator * any illness or use of medications that could affect sleep patterns (including sleep apnea) * dependency from the sponsor or the clinical investigator * participation in another investigation with an investigational drug or a pre-market medical device within the 30 days preceding and during the present investigation
the effects of sacral neuromodulation for urinary urgency, frequency, and urge incontinence

Conditions: Urinary Urge Incontinence

Summary: this prospective one group cohort study seeks to investigate the effects of sacral neuromodulation on urinary urgency, frequency and urge incontinence are maintained after the simulator device is temporarily turned off for a period of four weeks.

urinary urgency, frequency, and urge incontinence are very common symptoms, affecting up to one in three adults in the united states. the total economic cost of these disorders was estimated to be above $12 billion in the year 2000, with the vast majority being for women. sacral neuromodulation (snm) has become a popular and successful treatment option for people who suffer from these conditions. sacral neuromodulation device delivers electrical pulses to an area near the sacral nerve. there has been some data published which showed that for patients with fecal incontinence, symptom relief can persist for significant time periods despite having the stimulator device turned off. based on their findings, potential exists to prolong battery life if patients can cycle the on and off periods for their device while keeping their symptoms stable. the typical battery life of the implantable pulse generator (ipg) is approximately 5 years depending on the system settings. when the ipg is at the end of its battery life, a new ipg must be implanted. the cost of replacing the ipg ranges from $13,952 to $16,470. ipg replacement must be done in the operating room and requires the patient to undergo anesthesia and its associated risks. this study will investigate whether the symptoms of urinary urgency, frequency, and urge incontinence remain stable in patients with snm with the device turned off for a period of four weeks. current cincinnati urogynecology associates (cua) patients who are currently being successfully treated with sacral neuromodulation for the primary diagnosis of urinary urge incontinence or urgency and frequency who elect participate in the study will have the device turned off for four consecutive weeks. their symptoms will be monitored during this time period.

Eligibility criteria:
inclusion criteria: * women, aged 18-85 with who have previously had the interstim device implanted and have experienced good control of their symptoms for at least one year. exclusion criteria: * patients with less than 6 months of expected battery life on their device established at office testing. * patients with poor control of their symptoms within the last one year. * patients with degenerative neurological disorders or spinal cord injuries. * patients with cognitive disabilities or those lacking the mental capacity to understand and answer questionnaires. * patients who are pregnant or may become pregnant.
effect of gender on depression and periodontal status

Conditions: Periodontal Diseases; Depression; Gender; Gingival Diseases

Summary: there is a relationship between depression and periodontal disease. this relationship may be double-sided. a psychological state such as anxiety, depression, body image, and self-esteem may be affected from the symptoms of periodontal disease.

background: depression is a multifactorial disease characterized by a variety of symptoms. individuals with psychiatric disorders seem to be more prone to periodontitis. however periodontal disease and depression can be considered bidirectional risk factors. periodontal diseases can also be an effect on depression. the purpose of the present study was to evaluate the gender-related differences in the relationship between periodontal diseases and depression in male and female adults. material and methods: the study population consisted of 339 subjects. two groups were formed from these patients: 171 females with periodontal disease (71 subjects with gingivitis, 100 subjects with periodontitis); 168 males with periodontal disease (72 subjects with gingivitis, 96 subjects with periodontitis). clinical periodontal and psychological measures were performed on females and males group.

Eligibility criteria:
inclusion criteria: * the presence of periodontal diseases exclusion criteria: * the presence of any systemic disease other than depression * smoking and alcohol consumption * the use of any drugs (antidepressants, anti-inflammatory, and antimicrobial medicaments, and hormonal supplements) that affect the periodontal condition * have received any periodontal treatment in the last six months * hormonal condition such as pregnancy or lactation

Keywords: periodontal diseases depression gender gingival diseases
non interventional study on pulmonary valve replacement by thranscatheter pulmonary valve melody™

Conditions: Right Ventricular Congenital Cardiopathies

Summary: prospective, longitudinal, open-label, multicentre, observational, non-comparative national study using an exhaustive registry of implantations over a given period. this study is requested by french health authorities for reimbursement renewal, to maintain reimbursement for pulmonary valvular replacement by bioprothesis in approved indication in france.

this is a prospective, longitudinal, open-label, multicentre, observational, non-comparative national study using an exhaustive registry of implantations over a given period in france. the study is requested by french health authorities in 2010 for reimbursement renewal, to maintain reimbursement for pulmonary valvular replacement by bioprothesis in approved indication in france. the study was closed in 2013.

Eligibility criteria:
inclusion criteria: * patients requiring pulmonary valvular replacement for correction of right ventricular ejection path malfunction (stenosis and/or pulmonary regurgitation). exclusion criteria: * patient or legal representative refusal to data collection or processing * patient unable to guarantee follow-up data collection, in particular for patients living abroad
non-immunogenic staphylokinase in reperfusion therapy of ischemic stroke in routine clinical practice

Conditions: Acute Stroke

Summary: the study will collect data from aged 18 to 85 years with a diagnosis of acute stroke, who received thrombolytic treatment with a new agent, nonimmunogenic staphylokinase. outcomes will be checked for safety and compared to the results of treatment with the other thrombolytic drug, alteplase.


Eligibility criteria:
inclusion criteria: * age 18-85 ; * diagnosis of acute ischemic stroke eligible for thrombolytic therapy; * thrombolytic therapy with the drug "non-immunogenic staphylokinase" is planned or has already been performed. exclusion criteria: * individual intolerance or known hypersensitivity to a recombinant protein containing the amino acid sequence of staphylokinase; * the presence of a contraindication to thrombolytic therapy of ischemic stroke; * pregnancy or lactation.

Keywords: stroke thrombolysis acute ischemic stroke reperfusion
efficacy of an intervention to improve the preoperative shower in scheduled surgery

Conditions: Surgery; Surgical Site Infection

Summary: the aim of the project is to evaluate the effectiveness, on the skin cleanliness of the patient on arrival at the operating room, of an intervention aimed at improving the performance of the preoperative shower, for patients undergoing a planned surgical intervention in an orthopedic surgery department, digestive, gynecological, thoracic, or vascular.

the project will be realized in 2 phases. - the first phase of the project will consist of a sociological survey conducted with caregivers and patients in the care sectors participating in the study. this component sociological research will be carried out on the basis of in-depth interviews with caregivers (nurses and nursing assistants) from the departments concerned by research and patients. the expected sample, subject to data saturation, is 40 caregivers and 20 patients. these in-depth and non-directive interviews will be carried out by a sociologist and will aim to explore the way in which healthcare professionals see their activity professional, the relationship they maintain with the various members of the healthcare team, their perceptions of the body, privacy and hygiene of patients, but also to explore the representations of caregivers of the preoperative shower and of the relationship with caregivers during phases of explanation, possible help with the shower, and control of cleanliness cutaneous. these interviews will identify the representations of caregivers and patients with the aim of establishing a procedure for caregivers to improve care of the preoperative shower. in view of the statements of patients and caregivers concerning preparing for the preoperative shower and checking skin cleanliness during the survey exploratory, it appears necessary to improve and formalize the protocol. investigation will thus establish a base of knowledge necessary to establish a care procedure giving an account of the roles of each person, caregivers and patients.

Eligibility criteria:
inclusion criteria: 1. age 18 and over, and 2. scheduled for surgery (outpatient or full hospitalization) in one of the following specialties: orthopedics, digestive (including bariatric surgery), gynecological, thoracic, vascular, and 3. having read and understood the briefing note and not showing up for research. exclusion criteria: 1. operated on urgently, or 2. operated on for an intervention other than orthopedics, gynecology, digestive surgery, vascular surgery, or 3. having received a toilet in bed, or 4. having expressed their opposition to the research.

Keywords: surgery surgical site infection
non-opioid based pain control after thyroidectomy

Conditions: Pain; Thyroidectomy

Summary: pain control modalities were evaluated after thyroidectomy.

pain control modalities were evaluated after thyroidectomy. patients were randomized to one of two pain control regimens. the control group received conventional opioid based post operative analgesia while the test group received an enhanced recovery after surgery (eras) based anesthesia with use of acetaminophen and non-steroidal anti-inflammatory drugs for the post operative period with opioid medications available for break through pain only. pain scores (measured on visual analog scale) and opioid use (measured in morphine equivalent dose) were measured after completion of the operation.

Eligibility criteria:
inclusion criteria: * thyroid disease exclusion criteria: * currently on opioid pain medications * on opioid pain meds in last 30 days * cannot take non-opioid medications * require more extensive operation than thyroidectomy
efficacy and safety of propranolol versus atenolol on the proliferative phase of infantile hemangioma

Conditions: Hemangioma

Summary: the purpose of this study is to compare the efficacy of orally administered propranolol versus atenolol in the treatment of potentially disfiguring or functionally threatening ihs.

currently, propranolol is the preferred treatment for problematic proliferating infantile hemangiomas (ihs). although propranolol is clearly efficacious, rare side effects, such as hypoglycemia, may be life-threatening. the possibility of propranolol resistance and treatment failure is also important, and highlights the need for employing more established techniques in certain cases. nonselective β-adrenergic antagonists, such as propranolol and timolol, are competitive antagonists of catecholamines at the β1- and β2-adrenergic receptors (β-ars). β2-ar blockade may result in hypoglycemia as a result of decreased glycogenolysis, gluconeogenesis, and lipolysis. moreover, bronchial hyperreactivity is a direct effect of nonselective β-blockers, resulting in bronchospasms due to pulmonic β2-ar blockade. a solution to minimize many of the side effects of nonselective β-blocker therapy may be the use of more selective β1-blockers such as metoprolol or atenolol, which, at low dosages, have little β2 activity. unfortunately, there is a paucity of clinical data comparing the efficacy of selective and non-selective β-blocker. furthermore, because of the broad heterogeneity of ih (e.g., proliferating versus involuting), confounding with other pharmacologic exposures (e.g., corticosteroids), associated complications (e.g., ulceration) and comorbid medical anomalies (e.g., phace) that can influence efficiency after ih treatment, observational studies are unable to definitively establish the clinical utility of β-blockers in ih. thus, questions regarding the efficacy of the subtypes of β-blockers must be answered in randomized controlled trials, which may provide the only way to overcome the selection and ascertainment bias. the purpose of this study is to compare the efficacy of orally administered propranolol versus atenolol in the treatment of potentially disfiguring or functionally threatening ihs.

Eligibility criteria:
inclusion criteria: * patients younger than 24 weeks. * presenting a hemangioma with the following characteristics: * subcutaneous and/or cutaneous * minimum diameter of 1.5 cm on face, 3 cm outside face and 1.5 cm if it is ulcerated. * consent of both parents (or the person having parental authority in families) exclusion criteria: * infant presenting contraindications for the administration of propranolol or atenolol. * hemangioma has been previous treated with corticosteroids, laser, cryotherapy, or only other treatments. * patients with an inability to participate or to follow the study treatment and assessment plan.

Keywords: infantile hemangioma propranolol atenolol efficacy safety