Kornimate/medical-research-clean huggingface dataset:
hcapped i: hcap-pcr in emergency department

Conditions: Pneumonia; Bronchoalveolar Lavage; Antimicrobial Treatment; Sputum

Summary: prospective observational study (on diagnostic procedure) - single-center, non-profit. a pilot study will be conducted on a prospective cohort of patients with hcap (healthcare-associated pneumonia). this study will be conducted on a single arm of patients. no control group or randomization is planned. the use of syndromic molecular panels in pneumonias with risk factors for mdr (multidrug-resistant) pathogens, such as in patients with hcap, has become common practice. however, the use of this tool is reserved for patients with severe forms of hcap (piro\&gt;2, at least moderate ards, and respiratory failure requiring high-flow oxygen during sepsis) (30), and it is not yet standardized by international guidelines. the decision to use this tool or not is currently at the clinician\&#39;s discretion and is usually reserved for the severe forms mentioned above. the study aims to determine if the early use of this tool has a real benefit on the management of antibiotic therapy for these patients in terms of therapeutic changes compared to corporate and international guidelines. duration of patient enrollment: 1 year. duration of the study: 1.5 years.


Eligibility criteria:
inclusion criteria: all patients over the age of 18 who undergo bronchoalveolar lavage (bal) in the emergency department (dea), with a rankin score of less than 5, and who are admitted to the emergency department with a diagnosis of healthcare-associated pneumonia (hcap) of bacterial, viral, or fungal origin. the diagnosis must be confirmed by clinical and radiological criteria according to the idsa guidelines, which include: new pulmonary infiltrate on chest x-ray, evidence that the infiltrate is of infectious origin, at least two of the following three clinical signs: fever higher than 38 °c, leukocytosis or leukopenia, purulent secretions. additionally, patients must meet at least one of the following criteria: * need for high-flow oxygen therapy (vm35 or fio2 \&gt;35%, reservoir, hfnc, niv, cpap) * intubation (iot) * sofa score ≥2 or psi score \&gt;85 (age 75 + ir) * horowitz index (pao2/fio2) \&lt; 200 exclusion criteria: * lack of consent * age under 18 or over 90 * pregnancy * life expectancy less than 3 months * hospital admission \&gt;48 hours (hospital-acquired pneumonia - hap) * rankin score ≥ 5 * community-acquired pneumonia (cap)

Keywords: bronchoalveolar lavage endotracheal aspirate antimicrobial treatment pneumonia hcap pcr multiplex moleculas syndromic panel bal bas eta sputum
a novel method of clipped axillary lymph node localization post neoadjuvant chemotherapy in breast cancer patients .

Conditions: Breast Cancer Female

Summary: to determine the feasibility of a novel technique of localization of clipped ln post neoadjuvant chemotherapy


Eligibility criteria:
inclusion criteria: * breast cancer patients with involved axillary ln \<3, * going for neoadjuvant chemotherapy exclusion criteria: -stage 4 breast cancer patients
phase 1 evaluation of h1 influenza vaccine delivered by mimix map

Conditions: Influenza

Summary: a phase 1, randomized, rater and participant blinded placebo controlled study to evaluate the safety, reactogenicity, tolerability and immunogenicity of a standard and a fractional dose of h1 influenza vaccine delivered by vx-103 (a mimix microneedle array patch (map) system) in healthy adults ≥18-39 years of age


Eligibility criteria:
inclusion criteria: * male or female aged 18 - 39 years inclusive * provide written informed consent to participate * healthy participants without acute or chronic, clinically significant pulmonary, cardiovascular, hepatic or renal functional abnormality o as determined by medical history, physical exam, laboratory screening * body mass index 18-35 kg/m2, inclusive, at screening exclusion criteria: * any medical condition that in the judgement of the investigator would make subject participation in the study unsafe. * having cancer or received treatment for cancer within three years (persons with a history of cancer who are disease-free without treatment for three years or more are eligible), excluding basal cell carcinoma (bcc) or squamous cell carcinoma (scc), which are allowed unless located at the vaccination site. * impaired immune responsiveness (of any cause), including diabetes mellitus. * receipt or plan to receive a non-study vaccine within 30 days prior to vaccination or 60 days after vaccination. * receipt of any influenza vaccine in previous 24 months and/or planned receipt of influenza vaccine for the duration of the study. * diagnosed influenza infection in the previous 24 months prior to screening. * diagnosed covid infection via medical personnel or at home test within the past 60 days prior to screening * allergy to influenza vaccine or components, or history of severe local or systemic reaction to any vaccination. * history of anaphylactic type reaction to injected vaccines * history of or current allergy to latex * history of guillain-barré syndrome. * positive test result for hepatitis b surface antigen (hbsag,), hepatitis c virus antibody (hbcab), or human immunodeficiency virus (hiv) types 1 or 2 antibodies at screening. * history of chronic obstructive pulmonary disease or history of other lung disease. * history of severe allergic reactions to eggs.
comparison of cardiac output measured by ultrasound dilution method and pulmonary artery thermodilution technique

Conditions: Cardiac Disease; Post Surgery Patients

Summary: cardiac output (co) is an important hemodynamic variable in the management of critically ill patients. the pulmonary artery catheter (pac) requires invasive techniques with potential complications and there is increasing interest in less invasive methods of measuring co. this study is designed to compare co values from pac thermodilution (cotd) and ultrasound dilution (coud).


Eligibility criteria:
inclusion criteria: * age ≥ 18 years of age * presence of arterial catheter plus central venous pressure monitor and pulmonary artery catheter for hemodynamic monitoring. exclusion criteria: * age \< 18 years of age * patients with structurally abnormal heart (e.g. shunt) (confirmed by history taking) * patients who have heparin allergy. (confirmed by history taking)

Keywords: cardiac output ultrasound dilution thermodilution
effects of physical training on bone turnover and quality of life in osteopenic postmenopausal women.

Conditions: Osteopenia; Bone Turnover Markers; Quality of Life

Summary: the aim of our research was to define both in vivo and in vitro whether and to what extent an high-impact exercise program would affect bone cell turnover and improve the qol in osteopenic postmenopausal women.

subjects were selected among those attending the "bone and mineral metabolism disorders" clinic of perugia university, italy, since may 2nd 2015 and january 31st 2016. a total of 33 post-menopausal women volunteered to participate in the study.

Eligibility criteria:
inclusion criteria: * postmenopausal * bone mineral density t-score less than -1 but more than -2.5 in the total hip or lumbar spine (l1-l4) by dual energy x-ray absorptiometry * be able to attend an exercise program 2 times per week over the 3-month period * stated availability throughout the entire study period exclusion criteria: * secondary causes of bone loss such as osteomalacia, glucocorticoid medication * co-morbidities that would interfere with participation in exercise such as severe heart or pulmonary disease, inflammatory joint disease, severe osteoarthritis, psychiatric condition * physical or orthopaedic disabilities that would place the subject at risk or limit their ability to perform exercise * a past vertebral fracture * history of chronic diseases, such as renal, hepatic, cardiac, and rheumatic diseases * current or prior use of drugs that could interfere with bone mass (i.e. glucocorticoids, antiresorptive drugs and hormonal replacement therapy)

Keywords: osteopenia physical activity bone turnover markers osteoprogenitor cells quality of life
obstetrical risk factors for the development of urinary and/or fecal incontinence

Conditions: Obstetric Risk Factors

Summary: evaluation of obstetrical risk factors for the development of urinary and/or fecal incontinence according to a questionaire the questionaire will be filled by the study investigators after the women participating in the study sign their consent. the study is based solely on a questionaire and does not include any physical examination, blood exam or intervention. the study will be performed on the premises of maaynei hayeshua medical center. the inclusion criteria include women above the age of 18 who arrive to maaynei hayeshua medical center for any reason. the data will be transferred to a computerized data base and analyzed statistically.


Eligibility criteria:
inclusion criteria: * women of age 18 or above exclusion criteria: * women under the age of 18 * men

Keywords: incontinence obstetric risk factors women of age 18 above
clinical performance assessment of two silicone hydrogel daily disposable contact lenses

Conditions: Refractive Errors; Myopia

Summary: the purpose of this study is to assess the overall clinical performance of a contact lens made with a modified manufacturing process.

the expected duration of subject participation in the study is approximately 4 days with 2 scheduled visits.

Eligibility criteria:
key inclusion criteria: * successful wearer of spherical soft contact lenses of the same brand in both eyes for a minimum of 5 days per week and 10 hours per day during the past 3 months. * manifest cylinder equal to or less than 0.75 diopter (d) in each eye. * best corrected visual acuity (bcva) better than or equal to 0.10 logmar in each eye. * other protocol-specified inclusion criteria may apply. key exclusion criteria: * any use of topical ocular medications and artificial tear or rewetting drops that would require instillation during study participation. * wearing habitual contact lenses in an extended wear modality (routinely sleeping in lenses for at least 1 night per week) over the last 3 months prior to enrollment. * habitual monovision or multifocal contact lens wearers. * other protocol-specified exclusion criteria may apply.
dynamic contrast-enhanced fluorescence arthroscopy of meniscus pilot

Conditions: Knee Injuries

Summary: single-center pilot prospective observational study to determine feasibility of assessing meniscal tissue vascularity using dynamic contrast-enhanced fluorescence arthroscopy

the purpose of this pilot study is to determine whether it is possible to translate the dynamic contrast-enhanced fluorescence imaging methods we have been using to assess bone perfusion in orthopaedic trauma patients to the field of arthroscopic surgery. in other words, it is the development of dynamic contrast-enhanced fluorescence arthroscopy. while fluorescence arthroscopes are available, there are several challenges associated with minimally invasive procedures compared with wide field imaging, and this pilot study will help determine whether these can be overcome. they are mainly to do with motion artifacts caused by the non-fixed position of the scope during wash-in/wash-out of the dye, and the use of an arthroscopic pump to pressurize the fluid in the surgical cavity. the long-term goal of this work is to use dynamic contrast-enhanced fluorescence arthroscopy for the assessment of vascularity of meniscal tissue arthroscopically to determine potential healing capacity using dynamic contrast-enhanced fluorescence imaging.

Eligibility criteria:
inclusion criteria: 1. patients 18 years of age or older. 2. meniscal tear based on mri or preoperative assessment 3. provision of informed consent. exclusion criteria: 1. inability of patient to provide informed consent 2. iodine allergy. 3. evidence of septic arthritis of the proposed surgical joint. 4. burns. 5. incarceration. 6. expected survival of less than 90 days. 7. problems, in the judgment of study personnel, with maintaining follow-up with the patient. 8. pregnant or breastfeeding women

Keywords: meniscus indocyanine green fluorescence imaging
fruquintinib in refractory metastatic colorectal cancer: a real-world study

Conditions: Colorectal Cancer; Refractory Colorectal Cancer; Metastatic Colorectal Cancer

Summary: fruquintinib is an oral tyrosine kinase inhibitor (tki), which improves progression-free survival (pfs) and overall survival (os) in patients with refractory metastatic colorectal cancer (mcrc). here, we explore the real-world treatment patterns of fruquintinib in the third- or late-line setting for mcrc in six centers in china.


Eligibility criteria:
inclusion criteria: (1) histology-confirmed metastatic crc (mcrc); (2) disease progression on standard therapy with at least two lines of chemotherapy, including fluorouracil, oxaliplatin, and irinotecan with or without biologics such as bevacizumab and cetuximab; (3) fruquintinib administered as salvage treatment; (4) available clinical data. exclusion criteria: (1) lack of follow-up data; (2) fruquintinib administration as second-line treatment; (3) fruquintinib administration stopped after less than two cycles.

Keywords: fruquintinib
regional native american community networks program (rnacnp)

Conditions: Colorectal Cancer

Summary: aim: determine the overall effectiveness of a targeted digital messaging intervention at improving colorectal cancer (crc) screening rates compared to care as usual. hypothesis: screening rates will be higher for patients who receive the digital messaging intervention, compared to the control group in which patients receive care as usual.

native people for cancer control is one of the projects under partnerships for native health, and is 1 of 23 community networks programs funded by the national cancer institute. the aim of native people for cancer control is to reduce cancer health disparities by conducting training, research, education and outreach, in collaboration with american indian and alaska native communities. we do this work in partnership with native people, communities, and organizations in an 8-state area, including: alaska, washington, wyoming, oregon, idaho, montana, north dakota, and south dakota. our program consists of 4 cores: administrative core: assists with grant administration, budgeting, sub-contracts with tribes, program planning, and reporting. outreach/education core: assists with cancer education, outreach, health promotion, and cancer prevention activities among urban and rural ai/an people. training core: builds capacity for native faculty-level investigators, and students, to conduct research. research core: conducts community-based participatory research on colorectal cancer screening, health literacy, health communication, and cancer risk factors among american indian and alaska native people. the main research project under native people for cancer control is titled, "innovations in enhancing colorectal cancer screening". the goal of this project is to develop, implement, and evaluate a community wide, multi-media campaign to improve colorectal cancer screening among american indians and alaska natives in 3 communities.

Eligibility criteria:
inclusion criteria: * ai/an * age 50-75 * active clinical patient exclusion criteria: * not ai/an
recurrent pneumonia in children

Conditions: Pneumonia; Lower Respiratory Tract Infection; Chest Infection

Summary: this study aimed to analyses the clinical characteristics, risk factors and underlying causes as predictors of recurrent pneumonia in children attending auch

pneumonia is defined as inflammation of lung parenchyma due to various pathogenic organisms including bacteria, viruses, fungi and parasites. the key symptom to suspect childhood pneumonia is tachypnea. the world health organization (who) has defined tachypnea as respiratory rate \>60 breaths/min in infants less than 2 months, \>50 in infants 2 -12 months and \>40 in children 1 to 5 years and \>20 in children \>5 years of age \[1\]. who has categorized pneumonia in children under-five years of age into two categories, pneumonia and severe pneumonia. tachypnea with or without chest retraction is categorized as pneumonia while tachypnea with any danger signs (unable to feed or drink, hypothermia, unconsciousness, convulsion, signs of hypoxia including cyanosis, grunting, groaning, head nodding) as severe pneumonia \[1\]. pneumonia is a common and described as the overlooked killer of children\[2\] as killing 1.1-1.4 million children every year. it accounts for 17%-19% of all deaths amongst children under 5 years of age; the majority of them are in developing countries \[3,4\] .in egypt, children under 5 years approximate 13.4% of the total population\[4\] and pneumonia constitutes 19% of under-five mortality\[5\]. recurrent pneumonia (rp) is defined as at least two episodes of pneumonia in one year or three episodes ever, with intercritical radiographic clearing of densities \[6\]. incidence data indicate that rp occurs in 7.7%-9% of all children with cap \[7,8,9,10,11,12\]. as a result, rp represents a frequent presenting manifestation in the general pediatric practice and is a very common reason for referral to pediatric chest physicians \[7\]. factors linked to these infections could be recurrent aspirations, congenital structural anomalies of pulmonary and cardiovascular systems, defects in the clearance of airway secretions and immunodeficiency \[13\]

Eligibility criteria:
inclusion criteria: * • all children more than 1 month and less than 18 years of age * all cases presented by picture of recurrent pneumonia in the form of as at least two episodes of pneumonia in one year or three episodes ever, with radiographic clearing of densities in between. exclusion criteria: * • all children less than 1 month and more than 18 years * evidence of malignancies * evidence of congenital immune deficiency * cases refusing to participate in research. * cases missed for follow up.
the relationships between physical activity level, quality of life and cognitive level in breast cancer patients

Conditions: Physical Activity; Patient; Quality of Life; Chemotherapy

Summary: the aim of this study is to determine the relationships between physical activity level, quality of life and cognitive level in patients with breast cancer and to compare the results with a population of similar age group.

this study is a cross-sectional, analytical type study and will be conducted with chemotherapy patients diagnosed with breast cancer and treated in aydın adnan menderes university faculty of medicine research and practice hospital, department of oncology. patients diagnosed with breast cancer and undergoing chemotherapy will be provided by the researcher to fill out the questionnaires. healthy peers will also form the control group. first of all, mini mental test will be applied to all participants and those who get at least 24 points from the test will be included in the study. international survey of physical activity (ipaq),eortc qlqc30 quality of life scale,montreal cognitive assessment scale (moca) will be administered to all participants face to face by the researcher. the hypotheses the investigators will test for this purpors; h0; there is no relationship between physical activity level, quality of life and cognitive level in patients with breast cancer. h1a: physical activity level of patients with breast cancer affects their quality of life. h1b: physical activity level affects cognitive level in patients with breast cancer.

Eligibility criteria:
inclusion criteria: * being treated at aydın adnan menderes university faculty of medicine research and application hospital * being diagnosed with cancer at least 3 months before the study and receiving chemotherapy treatment * mini mental test result of at least 24 * to be conscious, * be over the age of 18, * being diagnosed with mass-style cancer, * patients with walking function in the healthy control group: * over 18 years * never been diagnosed and treated for cancer before * volunteers who do not have a disease that will impair cognitive functions exclusion criteria: * patients with brain metastases * patients with cognitive and psychiatric problems * patients with a diagnosis of hematological type cancer * patients receiving palliative care will not be included in the study. for the healthy control group * with systemic disease * have a chronic illness * having problems that interfere with physical activity

Keywords: physical activity quality of life chemotherapy cognitive level
pectointercostal block for postoperative pain management after sternotomy

Conditions: Post Operative Pain

Summary: this randomized, controlled study is designed to assess the quality of analgesia provided by ultrasound-guided bilateral pectointercostal facial block in children undergoing cardiac surgery via midline sternotomy.

following approval from the research and ethics committee ,preoprrative preparation, and induction of anesthesia the patient will be assigned to two equal groups. conventional control group(c) (n=30) where --- children will not receive any intervention. pectointercostal facial group (pi) (n=30) where --children will have bilateral pectointercostal block. patient positioning and preparation for ultrasound-guided pifb after skin disinfection, the pifb will be performed in a supine position using a high-frequency (6-13 mhz) linear ultrasound probe (s-nervetm; sonosite inc., bothell, wa, usa). the probe will be placed at 2 cm lateral from the sternum and parallel to the sternum and will be scanned laterally to identify 4th and 5th costal cartilage the pecto-intercostal fascial plane will be located between the pectoralis major muscle and the external intercostal muscle or the costal cartilage. a 22g, 50 mm peripheral block needle, stimuplex® ultra 360 (b. braun, melsungen, germany) will be placed under the pectoralis major and above the external intercostal muscle with an in-plane approach with the ultrasound probe, in a caudal-to-cranial direction until the tip is positioned in the interfascial plane between the pmm and iim . a test bolus of saline (1 ml) will be injected to determine that the tip has been placed in the correct fascial layers. finally, 1.5 mg/kg of 0.2% bupivacaine will be injected into this plane in two locations, over the 2nd and 4th rib. the method on the other side of the pifb will be the same care will be taken not to cross the toxic dose of bupivacaine (3 mg/kg). (6) . heart rate, mean arterial pressure, and oxygen saturation will be monitored continuously. after completion of the surgery, inhalational anesthetics will be stopped as well as the muscle relaxant. the patient will be then transferred to the icu.postoperative assessment and analgesic regimen: an iv paracetamol 15 mg / kg will be given and will be repeated every 8 hours .the face, legs, activity, cry, consolability scale (flacc) (table 1) will be assessed in the picu and every 4 hours for 24 hours. the time to the first request of rescue postoperative analgesic will be: "the time interval between the onset of block and the first request to postoperative analgesia". when patients first complain of pain (flacc score ≥4) rescue analgesia will be given in the form of incremental intravenous morphine

Eligibility criteria:
inclusion criteria: * age 6 to 36 months * sex both * weight \> 5kg * pathology a-v canal , asd closure, vsd closure surgery through a midline sternotomy. exclusion criteria: * redo patient. * history of allergic reactions to local anesthetics. * bleeding disorders with inr \> 1.5 and/or platelets \< 50 000. * rash or signs of infection at the injection site. * emergency procedures.