Kornimate/medical-research-clean huggingface dataset:
preliminary neck classification study

Conditions: Neck Pain

Summary: the purpose of this study was to assess if pain and function in patients with neck pain is less when physical therapists use a classification system.

the purpose of this study was to prospectively assess pain and function scores in patients with neck pain, with therapists specifically trained to implement a treatment based classification and matched interventions system. this study consisted of two phases to determine whether implementing a classification changed patient outcomes. in phase one, baseline data was obtained while physical therapists continued with their current neck pain evaluation and intervention approaches. the second phase involved educating the therapists in the neck classification system with the matched interventions. pain and function outcomes were analyzed for 2 phases. the overall goal was to prospectively determine if the implementation of this classification system with matched interventions could enhance patient outcomes.

Eligibility criteria:
inclusion criteria: * licensed physical therapists * treat patients with neck pain on a regular basis exclusion criteria: * do not utilize interventions included in the study

Keywords: neck pain cervical classification outcomes physical therapy
a study to compare the efficacy and safety of scenesse and narrow-band ultraviolet (nb-uvb) light versus nb-uvb light alone in patients with vitiligo

Conditions: Vitiligo

Summary: the cuv105 study will assess the efficacy and safety of afamelanotide and nb-uvb light in patients with vitiligo on the body and face versus nb-uvb light alone.


Eligibility criteria:
inclusion criteria: * male and female patients with a confirmed diagnosis of generalized vitiligo with vasi≥3 of the body and vasi on the head and neck ≥0.3 including an f-vasi≥0.1 * stable or active vitiligo * aged 12 or more * fitzpatrick skin types iii-vi exclusion criteria: * fitzpatrick skin types i-ii * extensive leukotrichia * treatment with nb-uvb phototherapy in the last three months prior to study start * allergy to afamelanotide or the polymer contained in the implant * any other treatment for vitiligo within 30 days prior to the screening visit * history of melanoma or lentigo maligna * history of dysplastic nevus syndrome * any malignant skin lesions * presence of severe hepatic disease or hepatic impairment * female who is pregnant or lactating * female of child-bearing potential not using adequate contraceptive measures * sexually active man with a partner of child-bearing potential who is not using adequate contraceptive measures * use of any prior and concomitant therapy which may interfere with the objective of the study * extensive tattoos
effects of beef protein consumption on energy intake

Conditions: Obesity; Severe Overweight

Summary: the purpose of this study is to determine ad libitum daily energy intake, body weight changes and appetite profile in response to protein/carbohydrate and fat ratio over 12 consecutive days, and in relation to age, gender, body mass index (bmi) and fat mass and obesity-associated (fto) gene alleles.

the protein leverage hypothesis requires specific evidence whether energy intake would depend on a possible protein intake target in humans. meat protein as complete protein may show most beneficial effects on variables regarding food intake regulation.

Eligibility criteria:
inclusion criteria: * healthy * age 18-70 years * bmi 18-35 kg/m2 * non-smoking * weight stable exclusion criteria: * smoking * use of medication * more than moderate alcohol consumption * vegetarian

Keywords: energy intake beef protein satiety protein leverage hypothesis
evaluation of the safety, tolerability, and pharmacokinetics of pln-74809 in participants with acute respiratory distress syndrome (ards) associated with at least severe covid-19

Conditions: Acute Respiratory Distress Syndrome; SARS-CoV-2

Summary: evaluation of the safety, tolerability, and pharmacokinetics of pln-74809 in participants with acute respiratory distress syndrome (ards) associated with at least severe covid-19

approximately 36 participants will be enrolled sequentially into 3 cohorts. within each cohort of 12 participants, 9 will be randomized to pln-74809 and 3 will be randomized to placebo (3:1 ratio). * in part 1, approximately 12 participants will be randomized to dose level 1 of pln-74809 or placebo qd * in part 2, approximately 12 participants will be randomized to dose level 2 of pln-74809 or placebo qd * in part 3, approximately 12 participants will be randomized to dose level 3 of pln-74809 or placebo qd

Eligibility criteria:
inclusion criteria: * diagnosis of ards (berlin criteria) * hospitalized with at least severe covid-19 (fda 2020) * receiving support for acute lung injury/respiratory distress via supplemental oxygen * serum aspartate aminotransferase (ast) concentration ≤ 120 u/l and serum alanine aminotransferase (alt) concentration ≤ 150 u/l * serum total bilirubin ≤ 1.8 mg/dl, in the absence of gilbert's syndrome or hemolysis exclusion criteria: * greater than 72 hours since time of onset of ards. * greater than 7 days since start of mechanical ventilation. * currently receiving or anticipated to receive extracorporeal life support (ecls), extracorporeal membrane oxygenation (ecmo) or high-frequency oscillatory ventilation * unwillingness to follow lung protective ventilation strategy (i.e., tidal volume of 6 ml/kg of predicted body weight and prone positioning) and fluid management protocol (fluids and catheters treatment trial \[factt\] conservative or lite) per local institutional standards (hfov).
routine pathological examination of hernia sac; is it a workload or necessary?

Conditions: Pathology

Summary: routine microscopic examination of the hernia sac is controversial. while some centers do not recommend a routine microscopic examination in inguinal hernias in adult patients, they recommend them in abdominal wall hernias. the investigators aimed to discuss the pathology results and unexpected histopathological findings who underwent abdominal wall and inguinal hernia operation in the light of the literature.

the hernia is defined as the passage of an organ or tissue from one anatomical region to another. hernia sacs are sent to the pathology department, although there is a difference between clinics. routine microscopic examination of the hernia sac is controversial. while some centers do not recommend a routine microscopic examination in inguinal hernias in adult patients, they recommend them in abdominal wall hernias. here, the investigators aimed to discuss the pathology results and unexpected histopathological findings who underwent abdominal wall and inguinal hernia operation in the light of the literature. patients who have operated hernia and sent hernia sac for histopathological examination were retrospectively screened. emergency and elective operated patients were included. hernia repairs without pathology were excluded from the study. patients' gender, age, operation notes, and pathology results were analyzed. pathology results were analyzed in two groups as expected findings and unexpected findings. in our study, the probability of encountering an unexpected pathological result was found to be quite low in the pathological evaluation of the hernia sac. although it may cause additional workload and cost, all hernia sacs should be sent to routine pathological examination. the investigators believe that making savings in these areas through further investigation after the decision of the pathologist.

Eligibility criteria:
inclusion criteria: * emergency operated patients * elective operated patients exclusion criteria: * hernia repairs without pathology examinations

Keywords: hernia sac inguinal hernia incisional hernia intestine omentum
transversus abdominis plane (tap) block for post caesarian pain

Conditions: Obstetrical Complications From Sedation During Parturition

Summary: adding tap block with bupivacaine may decrease the use of pca bolus use after caesarean section for pain relief.

participants in the study will be randomized to tap block with 0.5% or 0.25% bupivacaine or with placebo (normal saline). the number of pca bolus used within 24 hours post cesarean section will be compared between the groups.

Eligibility criteria:
inclusion criteria: healthy pregnant (asa ii) patients presenting for planned cesarean delivery at new york methodist hospital under combined spinal epidural anesthesia exclusion criteria: * they are unable or are unwilling to take part in the study * they have a history of allergy to any of the medications to be used in the study * they have a history of drug abuse or chronic pain or opioid use * they weigh less than 60kg * they have a multiple gestation, placental disease, preeclampsia other disease of pregnancy * they have a contraindication to neuraxial anesthesia (i.e., bleeding problems, bacteremia, etc.) * they are unable to understand instructions or questions related to the study * asa iii or iv
mindfulness-based vr for family caregivers of people with dementia

Conditions: Caregivers of People With Dementia; Quality of Life

Summary: the goal of this clinical trial is to explore the effectiveness of mindfulness-based vr could enhance depression, sleep quality, and overall quality of life for family caregivers providing care for people with dementia. participants will be ask to attend the six-week course encompassed various mindfulness practices, including breathing observation, body scanning, mindful yoga, mindful walking, holistic meditation, and non-selective awareness practices. the control group will only be given the mindfulness-based audio files for six weeks.

the inclusion criteria for participants were as follows: (1) being a family caregiver responsible for caring for a family member diagnosed with dementia by a medical institution, (2) having the ability to communicate in mandarin or taiwanese, and (3) providing informed consent to participate in the study by signing the consent form. individuals with visual and auditory impairments were excluded from the study. outcome measure: basic characteristics of participants; the center for epidemiologic studies depression scale; questionnaire of taiwan's world health organization quality of life brief version.

Eligibility criteria:
inclusion criteria: 1. being a family caregiver responsible for caring for a family member diagnosed with dementia by a medical institution, 2. having the ability to communicate in mandarin or taiwanese, and 3. providing informed consent to participate in the study by signing the consent form. exclusion criteria: visual and auditory impairments were excluded from the study.

Keywords: virtual reality depression sleep quality
adjuvant treatment in premenopausal breast cancer

Conditions: Breast Cancer Early Stage Breast Cancer (Stage 1-3)

Summary: multicentric retroprospective observational study to collect outcome in premenopausal breast cancer patients who undergone the 21-multigene assay oncotype dx from 1st january 2013 to 31st december 2022 and adjuvant treatment.

premenopausal patients who undergone the 21-multigene assay oncotype dx from 1st january 2013 to 31st december 2022 with any recurrence score (rs) and pathological nodal status pn0/pn1 will be included in the study. the study will collect clinical-pathological, genomic characteristics, adjuvant treatments (chemotherapy, endocrine therapy with/without ofs), and survival outcome (idfs).

Eligibility criteria:
inclusion criteria: 1. female, premenopausal and ≥18 years age patients. 2. agree to participate in study and signing informed consent or declaration in lieu of informed consent form, if applicable 3. histological diagnosis of early breast cancer hormone positive (er and/or pgr), her2-negative. 4. pathological nodal stage of pn0 or pn1 (1-3 nodes) and pathological tumor stage of pt1 to pt3. 5. surgery for primary breast cancer and axillary staging by sentinel node biopsy or axillary lymph node dissection (alnd). 6. availability of 21-multigene assay oncotype dx recurrence score results performed according to physician choice from 1st january 2013 to 31st december 2022 7. availability of clinical and pathological information. 8. availability of information about adjuvant treatment received. 9. availability of patient' outcome information (relapse, site of relapse, survival). exclusion criteria: 1. evidence of distant metastases 2. inflammatory breast cancer 3. neoadjuvant treatment 4. no surgery for primary breast cancer and axillary staging 5. patients not tested with 21-multigene assay oncotype dx

Keywords: premenopausal early breast cancer oncotype dx
serum calcium to phosphorous ratio (ca/p) as a simple, inexpensive screening tool in the diagnosis of primary hyperparathyroidism

Conditions: Hyperparathyroidism

Summary: background: primary hyperparathyroidism (phpt) is often overlooked and underdiagnosed. at present the diagnosis of phpt remains challenging and is based on serum calcium (ca) and pth. as serum ca and phosphorous (p) are inversely related in phpt, the ca/p ratio might be considered a good candidate tool in the diagnosis of phpt. aim: the aim of this study is to investigate the diagnostic value of the ca/p ratio in the diagnosis of phpt. study design: retrospective, observational, cross-sectional, case-control clinical trial will be carried out. biochemical measurements will include pth, vitamin d, serum ca, p, albumin, and creatinine.


Eligibility criteria:
inclusion criteria: * elevated parathormone serum levels * normal or elevated calcium serum levels exclusion criteria: * age younger than 18 years * renal and liver failure and insufficiency * active metabolic bone disease (such as paget's disease of the bone, osteomalacia, rickets, etc) * any type of cancer * malnutrition, severe obesity (bmi \> 40 kg/m2) and malabsorption * transplantation * sarcoidosis * endocrinological disorders such as hypercortisolism, diabetes insipidus, hyperthyroidism, pseudohypoparathyroidism * familial hypocalciuric hypercalcemia * hypophosphoremia sustained by genetic causes or secondary to other causes.
intervention to assist msm disclose hiv status to casual sex partners

Conditions: HIV

Summary: men who have sex with men (msm) remain disproportionately represented in the national hiv/aids statistics. little progress has been made in understanding the nuances of msm sexual behavior or communication that may be perpetuating the spread of hiv. non-disclosure of an hiv-positive status may be a key factor responsible for male-male hiv transmission. there are no known intervention programs whose primary focus is to help msm develop requisite skills to disclose their status to casual sexual partners. the development of such interventions is essential because of the numerous repercussions for not disclosing when one is hiv-positive such as legal prosecution and the transmission of hiv. in a previous intervention development study (r21mh067494) the research team created and tested a 4 session intervention found to be promising for increasing disclosure to casual sexual partners. the purpose of the proposed research is to further refine and enhance our hiv disclosure intervention (di) designed to increase disclosure to casual sexual partners and reduce sexual risk taking behaviors among hiv-positive msm; assess the relative effectiveness of a disclosure intervention to an attention control case management group (accm) for hiv-positive msm; examine the effects of the intervention over time; explore differential treatment responses to the disclosure intervention and accm on the basis of ethnicity, age, and education level as well as examine the mediating effect of baseline frequency of sexual activity, severity of substance abuse at baseline, and stigmatized fear on the relationship between intervention type and the outcome. finally, the investigators will test how treatment engagement, retention and expectations predict subsequent disclosure and risky sexual outcomes.


Eligibility criteria:
inclusion criteria: * hiv-positive * male * have sex with other men * over the age of 18 * sexually active in the past 90 days * 2 or more partners in last 12 months * indicate an interest in learning more about disclosing serostatus to casual sex partners * speak and understand english * plan on living in tampa area for at least 1 year exclusion criteria: * women * hiv-negative * children under the age of 18 * men who exclusively have sex with women * those who cannot speak and understand english * those who have not been sexually active or are behaviorally monogamous

Keywords: disclosure, intervention hiv prevention disclosure intervention attention control case management
virtual chromoendoscopy for distal polyps

Conditions: Colorectal Polyps

Summary: to assess the accuracy of predicting histology with virtual chromoendoscopy for distal colorectal polyps according to the asge pivi statement.


Eligibility criteria:
inclusion criteria: * written informed consent * screening or surveillance colonoscopy exclusion criteria: * history of inflammatory bowel disease * poor bowel preparation * colectomy * anticoagulation * polyposis syndrome
the effects of green exercise program consisting of 12-week aerobic and resistance exercises on sleep quality, alexithymia, anxiety and depression in elderly people

Conditions: Elderly; Exercise

Summary: the aim of this study is to investigate the effects of combination of aerobic and resistance exercises in the green exercise concept on depression, anxiety, alexithymia and sleep quality of elderly individuals. elderly individuals over the age of 65 will be included in the study. two groups of 20 people each will take part in the study. one group will be given aerobic and resistance exercises for 12 weeks, 2 days a week in the green exercise concept, the other group will be the control group and will not be included in the exercise program. participants will be evaluated twice, at the beginning of the study and at the end of 12 weeks.

forty volunteer participants aged 65 years over will be included in the study. participants will be randomly divided into two groups as experimental and control group. while experimental group will receive both aerobic and resistance exercises and control group will receive no exercise. exercises will be held in an open and green area. depression, anxiety, alexithymia and sleep quality of elderly individuals will be evaulated at the beginning of the treatment and at the end of the twelfth week. the exercise program will be done for 12 weeks, 2 days a week.

Eligibility criteria:
inclusion criteria: * people aged over 65 years * be fit to participate in exercise program after the first cardiac examination by the physician * having a score above 24 in the minimental test exclusion criteria: * having neuromuscular disease * serious medical condition (for example, advanced malignancy or major neurological, psychiatric or endocrine disease, respiratory failure, etc.) * having an orthopedic disease that interferes with walking * having a score below 24 in the minimental test

Keywords: elderly exercise affective symptoms anxiety depression
occlusal splints in the treatment of sleep bruxism

Conditions: Sleep Bruxism, Adult; Splints; Sleep

Summary: occlusal splints are employed in the treatment of sleep bruxism. these appliances decrease sleep-related actions and damages bruxism, like grinding, tooth-wear, headache, and temporomandibular joint disorders. occlusal splints are produced both in hard and soft forms according to the used material. in this study, it was aimed to evaluate the effect of occlusal splint type on the sleep quality and occlusal force parameters of patients with sleep bruxism.

various splint designs have been used for the treatment of sleep bruxism that is made up of different materials: hard and soft splints. although, these splints have slightly different appearances and properties, in fact, scientific evidence supports both the use of hard and soft occlusal splints. hard splints are more preferred when compared to soft ones, thus, oft appliances have been less documented in the scientific literature. however, some studies suggested the use of soft-resin splints that are easily fabricated and may be inserted at an initial appointment, dental clinicians may desire the use of soft appliances. one of the advantages of these appliances is they are easy to tolerable to the patient and comfortable. additionally, these splints fit tightly and provide a flat plane during sleep. considering these advantages, the present study was designed to examine the effect of the use of different types of occlusal splints on the sleep quality and occlusal force of patients with sleep bruxism. for this purpose, the effect of two splints basically fabricated from two different materials were evaluated and compared. the null hypothesis was that the use of both occlusal splints would not change the values of sleep quality and maximum occlusal force of the patients with sleep bruxism.

Eligibility criteria:
inclusion criteria: - healthy participants with complete permanent dentition. exclusion criteria: * presence of a systemic disorder that could compromise the masticatory system (e.g., neurological disorders, epilepsy, cerebral palsy, among others), * systemic disorder or current use of drugs that could interfere, directly or indirectly, with muscle activity, * inappropriate behavior and/or refusal to cooperate with dental procedures and data collection, * tooth loss (except for third molars), * soft tissue abnormalities, * toothache report, * active periodontitis (presence of periodontal pockets involvement of the supporting tissues), * caries lesions, * use of orthodontic appliances, * use of dental prosthesis (fixed or removable partial). * subjects with moderate to severe malocclusions, diagnosed by using the orthodontic treatment need index (iotn) (scores 5 or 6 - severe and extreme need for orthodontic treatment) * alcohol or drug abuse,

Keywords: sleep quality occlusal splint bruxism
effect of bioptron on primary dysmenorrhea

Conditions: Dysmenorrhea

Summary: this study will be conducted to determine the effect of bioptron on pd through the assessment of serum progesterone level, and pain level measured by pressure algometry in addition to evaluation of the symptoms of pd and its effect on girl's quality of life through valid and reliable questionnaires which will be of valuable benefits in the women's health fields.

all females will be randomly divided into two equal groups: group a (control group): lt will include 28 participants suffering from pd taking vitamin d (vitamin d) supplements for three consecutive menstrual cycles. group b (study group): lt will include 28 participants suffering from pd who will take vitamin d (vitamin d) supplementations as in group a in addition to bioptron for 20 min daily for 7 days before the menstrual cycle along with the first three days of menstrual flow for three consecutive menstrual cycles. all females will be given a full explanation of the study protocol and a consent form will be signed by each female before entry in the study

Eligibility criteria:
inclusion criteria: all females will be clinically diagnosed by the gynecologist with primary dysmenorrhea. * self-reported history of pd, at least moderate pain due to menstrual cramps (\>4 on vas) * they have moderate symptoms of pd on the waildd questionnaire, (5-12) teheran et al., 2018). * their ages will be ranged from 18-24 years old. * their bmi will be less than 30 kg/m². * being a virgin. * having regular menstruation for the last 6 months (every 28-30 days with no intermittent bleeding). * voluntary acceptance to participate in the study. b) exclusion criteria: participants will be excluded if they have: * musculoskeletal or neurological disorders. * patients with a history of phototherapy allergy. * professional athletes (jill et al., 2012). * secondary dysmenorrhea pathology such as (endometriosis, fibroids, adenomyosis, and pelvic inflammatory disease) * menstrual irregularity. * using hormonal contraception (such as contraceptives or injections).