Kornimate/medical-research-clean huggingface dataset:
evaluating the effect of a mobile audio companion (elly) to reduce anxiety in cancer patients

Conditions: Cancer; Cancer Metastatic; Neoplasms; Breast Cancer; Lung Cancer; Glioblastoma; Prostate Cancer; Gynecologic Cancer; Colorectal Cancer; Sarcoma; Kidney Cancer; Bladder Cancer; Lymphoma; Leukemia; Head and Neck Cancer; Pancreas Cancer; Multiple Myeloma; Anxiety; Social Isolation; Stress; Loneliness; Melanoma; Uterine Cancer

Summary: this is a single-arm, prospective, interventional study in cancer survivors and patients to examine the feasibility of a mobile health application, elly (elly health inc.), to reduce levels of anxiety, stress, loneliness, and social isolation. participants will be given access to the elly phone application developed by elly health inc. and will be asked to complete questionnaires measuring quality of life at multiple timepoints during the study.


Eligibility criteria:
inclusion criteria: * diagnosis of cancer of any type and currently receiving cancer-targeted treatment or have received cancer-targeted treatment within 6 months of consent date based on self-report. cancer-targeted treatment includes chemotherapy, radiation therapy, hormonal therapy, biologic therapy, immunotherapy, and surgery. * 18 years or older * access to and ability to use an iphone (se+, ios 12.4+) * ability to understand and read english * have an understanding, ability, and willingness to fully comply with study procedures and restrictions exclusion criteria: - hearing loss or vision impairment that would preclude the participant from accessing and using the app (use of hearing aids or visual aids is acceptable) based on self-report.

Keywords: elly health elly app
effectiveness of spinal manipulation in fibromyalgia

Conditions: Fibromyalgia

Summary: the aim of this study is to evaluate whether spinal manipulation, which is a potential treatment method for musculoskeletal pain, has an additional contribution in patients with fibromyalgia receiving standard pharmacological treatment.

although fibromyalgia (fm) is quite common, success rates in conservative treatment are unsatisfying. combination of pharmacological and non-pharmacological applications is recommended in treatment. although the etiology of fm is not well known, characteristic findings such as hyperalgesia and allodynia suggest problems related to pain and sensorial processing in the central nervous system. it has been suggested that spinal manipulation can alter sensorimotor integration in the central nervous system and therefore can be used in the treatment of central sensitization syndromes. however, manual therapy applications, which were examined under the heading of chiropractic in the 2016 eular treatment recommendations, were not recommended due to the low quality (open-label, quasi-experimental) of the studies conducted so far. however, it has been suggested for future studies to investigate whether the combined use of pharmacological and non-pharmacological treatments is more effective than single modality management. but since then unfortunately a high level of evidence also could not be obtained related to use of spinal manipulation in fm due to reasons such as lack of reporting of the manual therapy methods used in detail, conducting studies involving mostly soft tissue techniques and not following consort recommendations. this study is planned as a prospective, triple-blinding, randomized controlled and 3-arm parallel group design clinical study considering the concepts that have been lacking the literature.

Eligibility criteria:
inclusion criteria: * being diagnosed with fibromyalgia according to the 2016 acr fibromyalgia diagnostic criteria * having been receiving pharmacological treatment for fibromyalgia for at least 2 weeks * vas pain score\> 4 exclusion criteria: * structural problem of the musculoskeletal system (acute spinal disc herniation, acute spondylolisthesis / lysis, fractures and dislocations, advanced degenerative changes, spinal stenosis) * pregnancy or breastfeeding * inflammatory or infectious disease * malignancy * neuromuscular disease * history of spinal surgery * unstable psychiatric disease * previously received manual therapy or having enough information about manual therapy to distinguish between sham and real therapy (researched online, watched videos...).

Keywords: fibromyalgia manipulation manual therapy spinal
comparison of the quality of life and the level of precarity of a diabetic population with and without foot ulcer in martinique

Conditions: Diabetes; Diabetes Mellitus; Foot Ulcer, Diabetic; Diabetes Complications

Summary: the aim of this study is to compare quality of life of diabetics with and without foot ulcer. investigators will compare their quality of life based on the mental health impact of foot ulcer.

diabetes is one of the most frequent pathologies in martinique (french west indies) in terms of prevalence, as are its complications. the diabetic foot ulcer is a real public health problem considering its impact on the island. it has already been shown that diabetic patients have a lower quality of life than the overall population. it is now time to compare the quality of life of diabetics with and without foot ulcer in martinique. such a complication has a social impact that should not be overlooked in primary, secondary and tertiary prevention.

Eligibility criteria:
inclusion criteria: * people of 18 years old and over, * diabetics living in martinique, * patient having been informed of the research, * patient agreeing to participate in the study. exclusion criteria: * minor patient, * hospitalized patients during inclusion phase, * patients with confusional syndrome, * patient presenting a cognitive state making it difficult to complete the questionnaire, * patient under legal protection, under guardianship or under curatorship, * patient who refused to participate in the study.

Keywords: diabete diabete complications diabetic foot ulcer socio-economic disparities
efficacy of smartphone application based rehabilitations in patients with chronic respiratory or cardiovascular disease

Conditions: Pulmonary Rehabilitation; Cardiac Rehabilitation

Summary: in republic of korea, it is not easy to practice standard pulmonary rehabilitation (pr) or cardiac rehabilitation (cr). in this study, the investigators will provide newly developed smartphone application to patients with chronic respiratory or cardiovascular diseases. the investigators want to confirm whether participants, who perform smartphone application based 12-week pr or cr program, present improved exercise capacity, dyspnea symptom, muscle strength, or quality of life.


Eligibility criteria:
inclusion criteria: * dyspnea symptom \>= mmrc 1 or nyha ii * adults between 20 years and 80 or years * chronic respiratory disease * fev1/fvc \< 0.7 or fev1\< 0.8 of predicted value in pulmonary function test * bronchiectasis in more than one lobe on chest computed tomography * fvc or dlco \< 0.8 of predicted value in pulmonary function test * chronic cardiovascular disease * reperfusion therapy for angina pectoris or myocardial infarction * heart failure with reduced ejection fraction (lvef \< 50%) exclusion criteria: * history of acute exacerbation within 4 weeks * unable to comply rehabilitation program * not suitable for study on decision by duty physician * no consent
triple daas regimen in treating non-cirrhotic hcv gt1b subjects

Conditions: Chronic Hepatitis C Infection

Summary: the study is designed to test the hypothesis that the addition of a protease inhibitor to dual ns5a-ns5b nucleoside prodrug analog will enhance antiviral efficacy and hence shorten the treatment duration to 3 weeks.


Eligibility criteria:
inclusion criteria: * age equal to or greater than 18 years, with chronic genotype 1b hcv infection; * hcv rna level \> 10,000 and \< 10,000,000 iu/ml at screening; * rapid response to triple daas therapy with less than 500 iu/ml plasma hcv rna level at day 2; * no evidence of cirrhosis. cirrhosis defined as any 1 of the following, within 6 months of study entry: 1. liver biopsy showing cirrhosis; 2. fibroscan showing cirrhosis or results\>12.5 kpa ; 3. fibrotest® score \>0.75 and an aspartate aminotransferase (ast): platelet ratio index (apri) \>2 during screening. exclusion criteria: * pregnant or nursing female or male with pregnant female partner; * hiv or chronic hepatitis b virus (hbv) infection; * hematologic or biochemical parameters at screening outside the protocol-specified requirements; * active or recent history (≤ 1 year) of drug or alcohol abuse; * hepatocellular carcinoma or other malignancy (with exception of certain resolved skin cancers); * history or current evidence of any condition, therapy, laboratory abnormality or other circumstance that might confound the results of the study, or interfere with the subject's participation for the full duration of the study, such that it is not in the best interest of the subject to participate.
kidney awareness registry and education

Conditions: Chronic Kidney Disease (CKD)

Summary: the purpose of this study is to evaluate the feasibility and acceptability of two different interventions aimed at improving health outcomes among patients with chronic kidney disease (ckd), who are at high risk of ckd progression. specifically, this study will examine how best to implement a provider-level intervention (access to a ckd-registry) and a patient-oriented intervention (automated telephone self-management (atsm) + health coach) on patient health outcomes, with a 2x2 factorial design.


Eligibility criteria:
inclusion criteria: * patients with ckd (defined as estimated glomerular filtration rate \< 60ml/min/1.73m2 or proteinuria consistently over 3 months) who speak english, spanish or cantonese and have a primary care provider exclusion criteria: * kidney transplant recipients; pregnant women; individuals with an egfr \<15 ml/min/1.73 m2; prevalent dementia; impaired cognition or severe mental illness; expected life expectancy \<6 months; no phone access; self-reported hearing impairment; severe visual impairment preventing use of a touch-tone telephone keypad; and non-study language

Keywords: ckd automated telephone self management registry ckd awareness self efficacy
cetrorelix pamoate in patients with symptomatic benign prostatic hypertrophy (bph)

Conditions: Benign Prostatic Hypertrophy

Summary: benign prostatic hypertrophy (bph) is a common and bothersome condition of aging men. it is characterized by an enlargement of the prostate occurring in human male over the age of 50 which increases in prevalence with age, and among those aged 50 to 80, about 40% report moderate or severe urinary symptoms of prostatism. the aim of treatment is to improve patients' quality of life which primarily depends on the severity of the symptoms of bph. current treatments of bph have a benefit / risk ratio which leaves room for improvement. for this study, study medication (cetrorelix pamoate or placebo) is administered by injection in the buttocks (intramuscular). all patients completing the double-blind portion (week 0 to 52) are eligible to receive the active drug during the open-label part of the study (week 52 to 90).


Eligibility criteria:
inclusion criteria: * benign prostatic hyperplasia, based on medical history * voiding symptoms exclusion criteria: * urgent need for prostate surgery or prior surgical treatment of the prostate or bladder * major organ dysfunction * eczema (atopic dermatitis) treated during the last 6 months * current or recent treatment with sexual hormone drugs or 5 α reductase inhibitors or botulinum toxin type a (botox) within the last 6 months prior randomization or with α blockers or saw palmetto within the last 6 weeks prior to randomization * urologic disorders including neurogenic bladder dysfunction due to diabetes mellitus or documented neurologic disorder, urethral stricture disease or history of pelvic radiation therapy * history of acute obstructive, infectious, or neurological disorders of the genitourinary tract within the last 3 months
examination of virtual supermarket (vmall) as an assessment of executive functions in children and adolescents with acquired brain injury

Conditions: Brain Injuries

Summary: the purpose of this research is to find whether or not there are differences in the executive functions during "shopping" in a "virtual mall", between children with acquired brain injury (abi) vs healthy children. the hypothesis is that there will be differences in time (more time to shop) and mistakes (more mistakes during shopping), in the abi group.


Eligibility criteria:
inclusion criteria: * children with abi * at least a year after injury * who have been discharged from hospital and back home exclusion criteria: * children with learning disabilities former to injury * visual disabilities or developmental disabilities

Keywords: year and more after tbi good vision at least one functinal hand cap[able od doing shopping during everyday life
deep learning for preoperative pulmonary assessment in thoracic ct

Conditions: Elective Thoracic Surgery; Pulmonary Function; Deep Learning

Summary: the trial was designed as a single-centre, non-interventional prospective observational study to utilize deep learning technology combined with computed tomography (ct) images to precisely predict the pulmonary function indicators of thoracic surgery preoperative patients.

preoperative pulmonary function tests are crucial in assessing perioperative complications or mortality risks and providing decision support for thoracic surgery. however, traditional pulmonary function assessment methods have significant limitations, including long testing durations, difficulties in patient cooperation, high false-negative rates, and numerous contraindications. thus, our study optimized the final model based on 1500 single inspiratory phase cts by transferring model parameters trained on 500 dual-phase respiratory cts, enhancing its predictive capabilities for pulmonary function. this adjustment suits real-world application demands, offering more convenient, comprehensive, and personalized preoperative pulmonary function assessment support. our study optimized the final model based on 1500 single inspiratory phase cts by transferring model parameters trained on 500 dual-phase respiratory cts, enhancing its predictive capabilities for pulmonary function. this adjustment suits real-world application demands, offering more convenient, comprehensive, and personalized preoperative pulmonary function assessment support.

Eligibility criteria:
inclusion criteria: * (1) signing of the informed consent form; * (2) male or female, aged 18-75 years; * (3) undergoing elective thoracic surgery; * (4) good preoperative pulmonary function cooperation and complete reporting; * (5) preoperative chest single/dual phase ct scans without significant artefacts and with complete imaging; * (6) the interval between preoperative pulmonary function and single/dual phase ct scans does not exceed one month. exclusion criteria: * (1) poor preoperative pulmonary function cooperation or missing reports; * (2) preoperative chest single/dual phase ct scans exhibit significant artefacts or image omission; * (3) the interval between preoperative pulmonary function and single/dual phase ct scans exceeds one month; * (4) complication with severe respiratory disorders (such as lung transplantation, pneumothorax, giant bullae, etc.); * (5) coexisting with other severe functional impairments; * (6) patients with obstructive lesions such as airway or esophageal stenosis; * (7) height beyond the predicted equation range (female \< 1.45m; male \< 1.55m); * (8) medication use before pulmonary function testing that does not meet the cessation guidelines; * (9) pulmonary function report quality graded d-f.
the sensitivity and specificity of sniff dog as a tool in diagnosing the suspected tumor patients

Conditions: Neoplasia

Summary: previous studies have demonstrated that sniff dogs can identify cancer patients from healthy subjects through sniffing exhaled breath air or blood or serum or urine or feces. it is hypothesized that sniff dogs may be used as a tool in identifying cancer patients in the high risk population or suspected patients. trained dogs will sniff serum from participants who are suspected to suffer from tumor by their physicians and not yet but will be diagnosed by pathological examination.the results will be compared with the outcome of the pathological examination.


Eligibility criteria:
inclusion criteria: * healthy volunteers who have been examined by the currently used procedures and find to be without tumors. * patients in the breast surgery, thoracic surgery, gynecological and neurosurgery departments with lesions with characteristics of tumors exclusion criteria: * patients who have had pathological results

Keywords: tumor cancer
polyunsaturated fatty acids (pufa) status and cognitive function in healthy young adults

Conditions: Attention; Memory; Mood; Mental Fatigue

Summary: to date, the relationship between omega-3 polyunsaturated fatty acids (n-3 pufas) in cognitively intact individuals has only been examined in a limited number of studies; it is at present unknown whether supplementation with n-3 pufas can improve cognitive function and mood in this population. further to this, it still remains to be established whether a relationship exists between peripheral fatty acid status-reflective of dietary n-3 pufa intake-and cognitive function in this population. the current study therefore aims to address this issue by exploring the relationship between serum pufas and specific cognitive functions in a sample of healthy adults. to this end, participants will complete a range of cognitive tasks evaluating performance across the domains of attention, memory and executive function. self-report mood assessments will be included as secondary measures.


Eligibility criteria:
inclusion criteria: * male/female * 18-35 years * healthy * no herbal supplements/prescription medications (excl. contraceptive pill) * non smoker * native english speaker exclusion criteria: * bmi ≥ 30

Keywords: n-3 pufas fish oil cognitive function healthy young adults
atypical orofacial pain diagnostics and differentiation.

Conditions: Persistent Idiopathic Facial Pain

Summary: orofacial pain is diagnosed for more than 1.9 percent of general population and for 0.3 percent origin of the facial pain is unknown. commonly atypical facial pain is treated as a neurological condition without an emotional or psychiatric evaluation. since atypical pain and mood affective disorders can be related, patients do not receive proper care for this condition. the aim of this study is to evaluate the relationship between atypical facial pain syndrome and affective mood disorders. we aim to assess patients' with no diagnosed organic pathology tendency towards anxiety, depression, sleep disorders and one of big five personality traits through self-rating questionnaires. we will compare the gathered data with biosensors from imotions software.


Eligibility criteria:
experimental group the experimental group will consist only of adult patients (18-70years old), who were clinically diagnosed with atypical pain syndrome (g50.1) after all diagnostic measures were performed. inclusion criteria: * adult patients (18-70years old) who were clinically diagnosed with atypical pain syndrome (g50.1). * patients who accepted terms of this research and has signed informed consent form. * patients were not previously diagnosed with a psychiatric disorder. exclusion criteria: * a potential participant of the study is not able to comprehend information regarding this study's protocol in both written and verbal forms or fails/refuses to sign an informed consent form. * patients who have a diagnosed organic pathology causing orofacial pain. * patients who are diagnosed with systemic diseases which may interfere with the study or patients who present with head or neck oncology pathologies. * patients who were previously diagnosed with a psychiatric disorder. control group control group will consist of patients who were subjected to maxillofacial fracture (any jaw unilateral fracture). these patients will be involved in this study if they are hospitalized/or have visited lithuanian university of health sciences hospital kaunas clinics department of maxillofacial surgery. inclusion criteria: * adult patients (18-70year old) who have been diagnosed with orofacial pain due to jaw fracture (s02.3, s02.4, s02.6). * patients who have signed an informed consent form. * patients who were not previously diagnosed with a psychiatric disorder. exclusion criteria: * a potential participant of the study is not able to comprehend information regarding this study's protocol in both written and verbal forms or fails/refuses to sign an informed consent form. * patients who are diagnosed with systemic diseases which may interfere with the study or patients who present with head or neck oncology pathologies. * patients who were previously diagnosed with a psychiatric disorder.

Keywords: persistent idiopathic facial pain
study on the influence of electroconvulsive therapy (ect) on homocysteine levels

Conditions: Depressive Disorder, Major

Summary: elevated homocysteine levels are associated with depression and cognitive impairment. when depression ameliorates due to treatment, homocysteine serum levels often normalize. aim of the present study is to investigate, whether repeated ect treatment leads to changes in homocysteine levels and if these changes are associated with the occurrence of cognitive impairment after ecs. 10 patients suffering from therapy-resistant depression shall be enrolled. patients are treated with repeated ect (three times the week). before, directly after and one day after ect treatment, blood samples are drawn and patients receive cognitive testing. depressive symptomatology is checked with different rating scales.

background: elevated homocysteine levels have been found in depressive disorders. the modulating effects of homocysteine on glutamatergic neurotransmission have been discussed to be an underlying cause of depression and can also lead to cognitive impairment and may facilitate seizures. electroconvulsive therapy is the most effective treatment for depression, but often leads to cognitive impairments. hypothesis: homocysteine levels normalize during rect. this normalization is associated with the clinical improvement of depression. short term changes in homocysteine levels (i.e. increase directly after ect) may explain the cognitive impairments of the patients. method: 10 patients with therapy-resistant depressive disorder are to be enrolled into the trial. patients are treated with rect, two to three times a week. blood withdrawal and psychometric analysis will be performed before, directly after and one day after ect treatment 1,4,7,10,(13). necessity of further treatment will be checked after the first 6 ects.

Eligibility criteria:
key inclusion criteria: * men and women aged 18 years or above * diagnosis of major depressive disorder (according to dsm iv) * secured therapy resistance (at least two trials with antidepressive medication of different classes for more then 4 weeks in adequate dosage) * written, informed consent key exclusion criteria: * major neurological or other diseases * current medication with antiepileptic drugs * history of major head trauma * any medical condition not allowing anesthesia

Keywords: ect depression homocysteine mthfr genotype