Kornimate/medical-research-clean huggingface dataset:
impact on the nitrogen balance, autonomy, safety and tolerance of enteral diets made of with nutrilon without lactose® fortified by concentration versus by maltodextrin and oil supplementation,after surgery for congenital heart disease, in infants.

Conditions: Congenital Heart Disease in Children

Summary: an adequate nutritional support after a cardiac surgery enhances the morbidity and mortality. after a cardiac surgery, the energy expenditure is estimated to be around 55 kcal/kg/d. the caloric intake is not the only important nutritional variable in picu. the protein intake objective is around 1,5g/kg/d in order to reduce muscular catabolism. the aim of this study is to compare the impact of an isocaloric enteral diet, either fortified by milk concentration (in order to increase the protein intake) or by a supplement of maltodextrin and oil in children from 0 to 2 years, after surgery for congenital heart disease.


Eligibility criteria:
inclusion criteria: * children from 0 to 2 years undergoing cardiac surgery (corrective or palliative) for congenital heart surgery, with or without extracorporeal circulation * expected stay of 5 days in picu after surgery * expected need of invasive ventilation for 48h after surgery * expected need for enteral feeding during 5 days. * obtaining the informed consent of the child's legal guardian after being informed of the goals, benefits and potential risks of this study exclusion criteria: * medical indications for specific diet * ecmo * dialysis
candesartan in heart failure assessment of reduction in mortality and morbidity (charm alternative)

Conditions: Congestive Heart Failure

Summary: a study to evaluate the effect of atacand on patients with heart failure with depressed left ventricular function


Eligibility criteria:
inclusion criteria: * male or female aged 18 or above * congestive heart failure with symptoms for more than 4 weeks before starting study * provision of informed consent exclusion criteria: * current low blood pressure with symptoms * liver disease considered significant by the study doctor * pregnant or lactating females

Keywords: congestive heart failure atacand candesartan
cardiovascular disease (cvd) in haemophilia

Conditions: Haemophilia; Cardiovascular Disease

Summary: life expectancy of hemophilia patients has improved considerably during the past decades and is approaching that of the general population. hemophilia patients are therefore likely to be confronted with age-related disorders in addition to their primary illness and related diseases. little is known about the occurrence of age-related co-morbidity, especially cardiovascular disease (cvd), in these patients. low clotting factor levels are hypothesized to protect against both atherosclerosis and thrombus formation, resulting in a reduced risk of ischemic cvd. cvd mortality has been reported to be lower in haemophilia patients than in the general population, but data on non-fatal cvd are lacking, and no adjustment for cvd risk factors has been made so far. the aim of our study is to assess the occurrence of cvd and its risk factors in a large cohort of haemophilia patients. in this prospective multicenter cohort study in a group of 700-800 male patients with haemophilia a or b aged 30 years or older from the netherlands and the uk, data on cvd history and cvd risk factors will be collected at baseline and compared with the general age-matched male population. overall qrisk2 cardiovascular risk scores will be calculated and also compared with the general population. during a follow-up period of 5 and 10 years the occurrence of cvd events will be recorded and compared with the expected occurrence based on the qrisk2 scores and with data from the general population.


Eligibility criteria:
inclusion criteria: * haemophilia a or b (mild, moderate or severe) * male gender * age 30 years or older * treated at participating haemophilia treatment center exclusion criteria: * no specific exclusion criteria

Keywords: haemophilia cardiovascular disease cardiovascular disease risk factors prospective qrisk2 hypertension hypercholesterolaemia diabetes obesity
paraneural sheath & fascial compartments surround brachial plexus at supraclavicular fossa during selective trunk block

Conditions: Musculoskeletal Diseases or Conditions

Summary: the aim of this retrospective study is to define the paraneural (fascial) sheath and fascial compartments that surround the brachial plexus at the supraclavicular fossa by reviewing previous ultrasound images from cases that have undergone ultrasound guided selective trunk brachial plexus block.

the optimal anatomical plane (relative to the nerve) or the "goal" for local anesthetic (la) injection during an ultrasound guided (usg) brachial plexus blockade (bpb) at the supraclavicular fossa is currently not known. usg bpb is often described as a "subfascial", "extra fascial", "intracluster", "interfascial", sub-perineural", "intraneural", "corner pocket" or "periplexus" injection. although this suggests that the local anesthetic is injected into different tissue planes or fascial compartments, even if such planes do exist, as seen in other regions such as popliteal sciatic nerve are not clearly defined at the supraclavicular fossa. however, recently with the use of high definition ultrasound imaging for usg selective trunk block (setb) and principal investigator has often observed distinct paraneural (fascial) sheath and fascial compartments surrounding the brachial plexus at the supraclavicular fossa. these connective tissue layers are also better delineated after the local anesthetic injection. the principal investigator believes these may be the connective tissue layers that previous researchers have referred to in different reports. currently there are no published data demonstrating the paraneural sheath and fascial compartment surrounding the brachial plexus in-vivo. principal investigator believes that this fascial layer and compartment influence the spread of la during usg bpb around the individual elements of the brachial plexus at the supraclavicular fossa and therefore, these anatomical structures have to be delineated so as to improve the safety, success and quality of usg bpb. this study will involve reviewing archived high definition ultrasound images in audio video interleave format from all adult patients who had undergone usg setb for surgical anesthesia during upper extremity surgery from january 1, 2020 to june 30, 2021 to define the paraneural sheath and fascial compartments that surround the brachial plexus at the supraclavicular fossa.

Eligibility criteria:
inclusion criteria: * archived high definition ultrasound images (datasets) in audio video interleave (avi) format from all adult patients who had undergone ultrasound guided selective trunk block for surgical anesthesia during upper extremity surgery since the year 2020 (from 01/01/2020 to 30/06/2021). exclusion criteria: * patients \> 75 years old * american society of anesthesiologists (asa) physical status \> ⅲ * previous history of surgery at ipsilateral neck.

Keywords: selective trunk block
sub vs trans-umbilical incision: a patient's satisfaction-centered trial

Conditions: Patient Satisfaction; Surgical Wound; Incision; General Surgery

Summary: while some studies have suggested that subumbilical and transumbilical incisions have a similar clinical efficiency and safety, no study has yet evaluated their respective impact on patient's postoperative aesthetic satisfaction. the objective of this randomised trial is to compare patient's postoperative aesthetic satisfaction depending on the type of incision which is performed during surgeries.


Eligibility criteria:
inclusion criteria: * patients 18-70 years old having a planned laparoscopic surgery with an umbilical first trocar at chus were included. exclusion criteria: * patients with a bmi \> 40 or that had previous abdominal surgeries involving the umbilicus were excluded.
bioavailability of hesperidine and narirutin from orange juice to identify metabotypes in hypertension

Conditions: Blood Pressure; Hypertension

Summary: flavonoids are polyphenolic compound mainly found in fruits and vegetables with numerous beneficial health effects as protection against cardiovascular diseases by an antihypertensive effect. the intestinal microbiota plays a key role in the metabolization of these compounds, so that differences in the composition and activity of the microbiota between individuals can generate different metabotypes. flavonoids are found mainly in their conjugated form linked to the monosaccharide rhamnose and need to be metabolized by the intestinal bacteria, releasing the rhamnose, to be absorbed and, thus, bioactive. the bacterial enzyme responsible of rhamnose hydrolysis is α-l-rhamnosidase, whose activity can vary considerably depending on the composition of the microbiota. in fact, a great interindividual variability has been observed in the ability to absorb flavonoids, which allows to classify individuals according to the corresponding metabotype. in a previous project, the investigators confirmed the interindividual differences in the bioavailability of hesperidin and narirutin, two flavonoids naturally present in orange juice. however, the role of the intestinal microbiota in the metabolism of hesperidin and narirutin needs to be elucidated. on this basis, the following hypothesis is presented: individuals with arterial hypertension can be classified into 3 different metabotypes that are the result of the ability to absorb hesperidin and narirutin, determined by the urinary excretion of their respective metabolites, and these metabotypes are associated with different microbiota enterotypes and with different fecal α-l-rhamnosidase activity.


Eligibility criteria:
inclusion criteria: 1. men and women over 18 years of age 2. systolic blood pressure ≤159 mm hg 3. sign the informed consent exclusion criteria: 1. body mass index (bmi) ≥ 35 kg / m2 2. glucose \> 126 mg / dl 3. systolic blood pressure ≥ 160 mm hg and diastolic blood pressure \> 100 mm hg or taking antihypertensive drugs 4. ldl cholesterol \> 189 mg / dl 5. triglycerides \> 350 mg / dl 6. anemia (hemoglobin ≤ 13 g / dl in men and ≤ 12 g / dl in women) 7. tobacco addiction 8. consumption of medicines, antioxidants or vitamin supplements 30 days before the study 9. use of antibiotics during the last 30 days prior to the study 10. consumption of prebiotics and / or probiotics during the 30 days prior to the study 11. clinical history of gastrointestinal disease or presence of intestinal disorders at the time of inclusion 12. chronic alcoholism 13. monitoring a vegetarian diet 14. pregnant or with intent to get pregnant 15. being in breastfeeding period 16. participation in a clinical trial or nutritional intervention study, in the last 30 days. 17. inability to follow the study guidelines

Keywords: hypertension flavonoids orange juice metabotypes
febuxostat-controlled, double-blind, comparative study of fyu-981 in hyperuricemia with or without gout

Conditions: Hyperuricemia With or Without Gout

Summary: fyu-981 or febuxostat are administrated to hyperuricemia patients (underexcretion and mixed types) with or without gout for 14 weeks to compare the efficacy and safety of these drugs by the method of multicenter, randomized, double-blind, ascending dose regimen.


Eligibility criteria:
inclusion criteria: * serum urate level: * \>= 7.0mg/dl in patients with gouty nodule or with history of gout, or \>= 8.0mg/dl in patients with hypertension, diabetes or metabolic syndrome, or \>= 9.0mg/dl * disease type in the classification of hyperuricemia: uric acid-underexcretion type or mixed type * outpatients exclusion criteria: * gouty arthritis within 14 days before randomized allocation * secondary hyperuricemia * hba1c: \>= 8.4% * clinically significant cardiac, hepatic, renal, hematologic or endocrine disease * kidney calculi or clinically significant urinary calculi * ast: \>= 100 iu/l or alt: \>= 100 iu/l * egfr: \< 30 ml/min/1.73m\^2 * systolic blood pressure: \>= 180 mmhg or diastolic blood pressure: \>= 110 mmhg
platysma trial - platysma suturing versus no sutures for wound closure after primary thyroid surgery

Conditions: Thyroid Disease

Summary: influence of the platysma suture on postoperative pain and wound healing.

does a running platysma suture after primary thyroid resection alter direct postoperative pain, wound healing and long term cosmetic results. primary outcome measure is if the lack of a platysma-suture decreases the postoperative pain (detected by the visual pain score 0-10) and reduces the pain medication (detected by the cumulative nsaid and opioid treatment per patient). the second question to be answered is if the cosmetic scar result (detected by the patient and observer scar assessment score) 6 month after thyroidectomy is better in the intervention group (no platysma-suture) or not.

Eligibility criteria:
inclusion criteria: * primary thyroid surgery exclusion criteria: * previous neck surgery * application of wound drainages * preoperative diagnosed malignancy * surgical extension beyond thyroid resection (e.g. lymphadenectomy) * preexisting coagulopathy * preexisting chronic pain syndromes * preexisting dependency on pain reliefs * preexisting disorders in wound healing (e.g. diabetes mellitus) * intolerance to any study medication

Keywords: thyroidectomy postoperative pain wound healing
conversations with caregivers about health and appearance

Conditions: Disordered Eating Behaviors; Depression; Feeding Behaviors; Parent-Child Relations

Summary: this clinical trial is evaluating the effects of a 2-hour, small group discussion with parents and caregivers of adolescents in oregon. we will evaluate whether parents'/caregivers' experience reductions in their disordered eating symptoms, mood symptoms, and parent-child relationship quality, relative to parent/caregiver participants in the wait list control. we will also evaluate whether the children of these parents/caregivers experience improvements in their disordered eating and mood symptoms.


Eligibility criteria:
inclusion criteria for parent/caregiver: * at least 18 years old * the primary caregiver of at least one child 12-17 years old who lives with them at least 50% of the time * living in the state of oregon * can read and understand english at the 6th grade level or higher * access to internet and private space for zoom inclusion criteria for the child: * 12-17 years of age * can read and understand english at the 6th grade level or higher
asthma learning project

Conditions: Asthma

Summary: the purpose of this study is to determine the effect on knowledge and behavior of playing an educational asthma computer game during a pediatric emergency department (ed) asthma visit among children ages 7 - 15 years. the ed cares for a high-risk population of children who have difficulty accessing preventive care well. the addition of a computer game to usual asthma emergency care could be a simple, effective, enjoyable way to improve patients' asthma knowledge, beliefs, and management practices. this project has the potential to lead to larger studies evaluating the benefit of education with and without behavioral interventions such as motivational interviewing. this project plans to implement and evaluate the use of a goal setting activity and the educational asthma computer game, "quest for the code" (starlight starbright children's foundationtm), in the ed of seattle children's hospital. in a randomized trial of spanish and english speaking children ages 7 - 15 years receiving ed care for their asthma, the investigators will evaluate the effects of the game on children's asthma knowledge, attitudes, and behaviors. the investigators aim to compare the change in asthma knowledge and locus of control after 3 months, for children who play the computerized asthma game, versus those who receive standard care in the ed. the investigators will also compare changes in asthma severity and activity limitations over 3 months, for children who play the asthma game without goal-setting, children who playing the game with goal-setting, and children who receive standard care. overall, the investigators hypothesize that educational asthma game play by pediatric patients with acute asthma will improve asthma knowledge, compared with standard care.


Eligibility criteria:
inclusion criteria: * age 7 - 15 years, inclusive. * patient has a history of asthma or asthma-like symptoms on at least 1 occasion, occurring at least 3 months prior to the current episode (may be verbal per patient/caregiver). * patient is presenting to the ed for an acute asthma exacerbation of any type or severity. * available for phone call or mail questionnaire in 2 weeks and 3 months. * parent able to read english or spanish. * child able to understand spoken english or spanish. * child able to use a computer and mouse or stylus. * provider believes the patient is likely to remain in ed for at least one hour. * informed consent by parent and assent from child exclusion criteria: * child has previously participated in this study. * child has a hearing impairment uncompensated for by assistive listening devices. * significant mental disorder or cognitive impairment that the parent believes would preclude competent informed assent or game play. * child has a baseline motor disorder and the parent is unable to assist using a mouse and keyboard * child has significant medial conditions that have a pulmonary component, in addition to their asthma
online interactive courses on loneliness and quality of life of older adults

Conditions: Older Adults

Summary: background: the early stage of the covid-19 pandemic can be marked as a critical period in human history as it increased loneliness in people's lives. this is particularly true for the older adults who are single, living alone, and suffering from chronic diseases. however, there is insufficient existing research on associated interventions and their effectiveness. objectives: to investigate the effectiveness of an 8-week online interactive course on the loneliness, depression, social support, and quality of life (qol) of older adults in the community during the covid-19 pandemic. methods: this pilot study, also a single-blind randomized controlled trial, collected data from a community in central taiwan. participants were randomly divided into an experimental group and a control group. subsequently, participants in the experimental group received an 8-week intensive (monday to friday) online interactive course, whereas those in the control group consumed 8 weeks of unidirectional online video and audio programs (such as from youtube). assessments were conducted both before and after the intervention, with the primary outcome being the ucla loneliness scale (ucla), and secondary outcomes being the geriatric depression scale short form, the inventory of socially supportive behavior (issb) scale, and the who quality of life-bref (whoqol-bref) scale.


Eligibility criteria:
inclusion criteria: * (1) senior residents aged over 60 years, those who were not diagnosed with any cognitive impairment; * (2) capable of communicating in mandarin or taiwanese; and * (3) capable of using smartphones. exclusion criteria: * (1) participants who could not fully complete the 8-week intervention (or participate in the course for at least three days per week); and * (2) those who were incapable of understanding the content of the questionnaire.
intraperitoneal administration of fosfomycin, metronidazole and molgramostim versus intravenous antibiotics for perforated appendicitis

Conditions: Appendicitis Perforated

Summary: the objective of this trial is to evaluate if intraoperative intraperitoneal administration of fosfomycin, metronidazole and recombinant human granulocyte-macrophage colony-stimulating factor (rhgm-csf) followed by oral antibiotic for three days is as effective as the current intravenous antibiotic treatment given during and three days after appendectomy for perforated appendicitis. the primary outcome is the total length of hospital stay, defined as the number of hours in hospital after end of operation and until 30-day follow-up.


Eligibility criteria:
inclusion criteria: * age ≥18 years * suspicion of acute appendicitis and planned for diagnostic laparoscopy and eventual laparoscopic appendectomy * perforated appendicitis (diagnosed during surgery by the surgeon) * negative p-hcg (women) * written informed consent after written and verbal information (preoperatively for the intervention group and postoperatively for the control group) exclusion criteria: * cannot understand, read or speak danish * previous allergic reaction to fosfomycin, metronidazole, rhgm-csf, or penicillins e.g. piperacillin or amoxicillin * diagnostic laparoscopy revealing normal appendix not requiring an appendectomy or appendicitis without perforation * other intra-abdominal pathology requiring surgical intervention at the same operation * known renal or hepatic disease or biochemical evidence at the time of admission * known hematologic disease in current medical treatment * american society of anesthesiologists (asa) physical status ≥4 (a patient with severe systemic disease that is a constant threat to life) * body weight \>110 kg * surgery converted to open appendectomy * anticipated compliance problems
diaplacental transfer of anti-hcmv- and anti-vzv-immunoglobulin g (igg) -antibodies at premature and mature newborns

Conditions: Materno-fetal Transfer of Anti-HCMV-IgG; Materno-fetal Transfer of Anti-VZV-IgG

Summary: the aim of the study is to determine the total concentration of hcmv- and vzv-specific igg-antibodies and the total concentration of neutralizing antibodies against hcmv in neonatal bloodstream depending on gestational age at birth.

for data gathering the investigators measure the main concentration of specific hcmv-/vzv-igg-antibodies and the concentration of neutralizing igg-antibodies against hcmv and vzv in maternal blood and in fetal bloodstream. then the investigators compare the data of mother and newborn. therefore, the investigators use the following blood samples: mother: venous blood sample taken at birth (+/- three days) newborn: blood sample of umbilical cord (= fetal bloodstream) taken immediately after birth. the investigators assign the data of each newborn (gestational age at birth) to the data of their respective mother for statistical evaluation. after finishing the study the investigators will destroy all residual blood.

Eligibility criteria:
inclusion criteria: * hcmv and/or vzv-seropositive pregnant woman who signed written informed consent form. exclusion criteria: * newborns of underage mothers. * newborns whose mother did not sign the written informed consent. * pregnant women with a known hereditary or acquired immune deficiency

Keywords: human cytomegalovirus varicella zoster virus materno-fetal antibody transfer pregnancy gestational age