Kornimate/medical-research-clean huggingface dataset:
interest of virtual reality in the management of anxiety and pain during embryo transfer (et)

Conditions: IVF; Stress; Anxiety

Summary: this study compares the use of virtual reality versus the usual service protocol for the management of anxiety and pain related to in-vitro fertilization (ivf) procedure

medical interventions often cause pain, distress or anxiety for most patients. the use of music and movies has proven effective in pediatrics. virtual reality (vr) is a newer technology that immerses users in a pleasant, three-dimensional environment via a headset. by distracting patients, this technology can reduce anxiety, discomfort and ultimately pain associated with care. this randomized monocentric trial compares the effect of the use of vr versus without vr during the transfer of a fresh blastocyst on the 5th day of development or a frozen embryo on the 5th day of development. the primary outcome will include clinical pregnancy rate and the secondary outcome focuses on the patient's levels of anxiety and stress. data on the level of anxiety and stress will be collected through questionnaires before and after the procedure. also, clinical pregnancy, defined by the presence of one or more gestational sacs with one or more embryos showing cardiac activity, will be assessed through ultrasons 8 ± 4 weeks after the procedure

Eligibility criteria:
inclusion criteria: * will benefit from in vitro fertilization (ivf or icsi) * aged over 18 and under 43, * attempt rank 1 or 2 * requiring a transfer of a single fresh blastocyst on the 5th day of development or a frozen embryo on the 5th day of development * having received information and given their consent to participate in accordance with the regulations * benefiting from a social security scheme or entitled. exclusion criteria: * use of frozen sperm * use of testicular sperm * fecundation technique used: imsi * early embryo transfer on d2 or d3 * inability to understand the information given * under guardianship, under curatorship or under safeguard of justice, * communication difficulties or neuropsychic disorders, * current corneal or conjunctival pathologies, * claustrophobia, * appearance of nausea in the mountains or at sea, * regular use of anxiolytics

Keywords: virtual reality embryo transfer pregnancy rate
covid-19 and psycological well-being in healthcare workers

Conditions: Distress, Emotional; Coping Behavior

Summary: well-being of healthcare workers is assessed by specific questionaries validated for resilience, depression, anxiety, coping strategies and fear for covid-19. after signing informed consent and privacy informed consent subject are asked to complete questionaries presented as google modules. no personal data are required.

well-being of healthcare workers is assessed by specific questionaries validated for resilience, depression, anxiety, coping strategies and fear for covid-19. data will be analysed to investigate levels of resilience in healthworkers that have been in contact with patients or relatives with covid-19. intervention strategies engaged by subjects are monitored to understand unmet feedings to promote well-being.

Eligibility criteria:
inclusion criteria: * healthworkers of san raffaele institution * age\>18 exclusion criteria: * all those who do not agree

Keywords: covid-19, resilience, depression, healthcare workers
stress and health interview for primary care patients with medically unexplained symptoms

Conditions: Somatoform Disorders

Summary: the goal of this study is to test the feasibility and acceptability of providing an experiential assessment interview that targets emotional and stressful experiences in primary care. in this randomized, controlled trial, the investigators will compare an interview condition to a wait-list control condition. the investigators hypothesize that helping individuals first identify the links between their stress and symptoms will likely increase their awareness and endorsement of the link between stress and physical symptoms, including a willingness to engage in stress management techniques. it is also expected that helping raise an individual's awareness about their symptoms, followed by an experience and expression of unexpressed emotions is likely to influence their physical symptoms and psychological status.

emotional stress, particularly when a patients inhibits their experiences and feelings, contributes to physical symptoms. however, primary care patients with medically unexplained symptoms are rarely assessed for the stress and emotions in an comprehensive manner. the goal of this study is to test the feasibility and acceptability of providing an experiential assessment interview that targets emotional and stressful experiences in primary care with medically unexplained physical symptoms. in this randomized, controlled trial, the investigators will compare an interview condition to a wait-list control condition. the interview will review patients health history, psychosocial history, make links between the two, and help patients identify and express emotions related to conflicts or victimization. the investigators hypothesize that helping individuals first identify the links between their stress and symptoms will likely increase their awareness and endorsement of the link between stress and physical symptoms, including a willingness to engage in stress management techniques. it is also expected that helping raise an individual's awareness about their symptoms, followed by an experience and expression of unexpressed emotions is likely to influence their physical symptoms and psychological status.

Eligibility criteria:
inclusion criteria: * participants must score above 10 (moderate range) on the patient health questionnaire-15, which is a measure of a range of medical symptoms that are often medically unexplained. exclusion criteria: 1. conditions that could interfere with the interview: * non-english speaking * psychosis * dementia * mental impairment 2. the presence of disease or injury that could account for the physical symptoms. - examples: autoimmune disease, bodily injury, serious infection, cancer, heart disease, copd, post-stroke.

Keywords: medically unexplained symptoms (mups) somatoform disorders chronic pain somatic symptoms emotional processing primary care
postamputation pain: peripheral mechanisms

Conditions: Neuropathic Pain; Amputation, Traumatic; Nerve Block; Phantom Limb Pain; Stump Pain

Summary: stump and phantom pain after amputation are common, but the responsible mechanisms are still not clarified. it has been suggested that phantom limb pain can be reduced by regional anaesthesia and in several recent studies, pain was reduced following intrathecal and intraforaminal blocks. in this study, the investigators want to investigate if spontaneous and evoked pain in amputees will be relieved by regional nerve blocks involving the damaged nerves.


Eligibility criteria:
inclusion criteria: * amputees with chronic amputation pain (stump or phantom pain) 3 or above on nrs (numerical ratio scale). exclusion criteria: * severe somatic or psychiatric diseases * other peripheral neuropathy * lack of ability to cooperate to the clinical examination * allergy to lidocaine or similar analgetics
study of retinal vascular parameters in patients with wilson's disease

Conditions: Wilson Disease

Summary: the rare disease reference center " wilson disease and other rare copper-related diseases" of the rothschild foundation follows a large number of patients with wilson's with varying degrees of impairment and located at different times of their care. many people with wilson's disease have a characteristic greenish-brown ring, known as kayser-fleischer, appearing at the periphery of the cornea due to a deposit of copper at the descemet membrane. as a general rule, if the patient is compliant with his treatment, the ring usually disappears within a few years, although it may persist in some patients. however, apart from the stage of diagnosis, and the evolution of the ring, ophthalmological examinations are little used for the follow-up of these patients. the objective of this study is to describe the retinal parameters, in particular vascular with two new retinal imaging technologies (oct-a :optical coherence tomography-angiography , adaptive optics) in patients with wilson's disease and to correlate them with the parameters of the usual follow-up of these patients (hepatic assessment, exchangeable plasma copper, neurological scores, compliance, etc.).


Eligibility criteria:
inclusion criteria: * wilson's disease with ferenci score ≥4 exclusion criteria: * neurological or behavioral handicap that does not allow for ophthalmological examinations * hepatic decompensation that does not allow for ophthalmological examinations * pregnant or breastfeeding woman

Keywords: optical coherence tomography adaptive optics
design and validation of a german language questionnaire for measuring alarm fatigue in intensive care units

Conditions: Alarm Fatigue

Summary: false-positive and non-actionable alarms can lead to staff desensitization ("alarm fatigue") and thus patient endangerment. with this study the investigators create a basic tool to survey alarm fatigue of intensive care staff: the first german language alarm fatigue questionnaire.

in intensive care units (icus), patients' vital signs are monitored automatically. as soon as one of the parameters indicates a critical or potentially critical condition, an alarm is triggered on the ward. however, if there are too many alarms, even most of which are false or require no treatment, ward staff may develop alarm fatigue and become desensitized to alarms. this puts patients at risk, especially by overhearing critical alarms. overburdening staff with alarms is part of everyday life in most icus. considering the demographic development as well as the covid-19 pandemic, it is to be expected that the number of intensive care patients and thus also the alarm burden in intensive care units will increase. this will also be exacerbated by the increasing digitization of the icu. evidence-based and data-driven alarm management enables clinicians to trust alarms again. with this study the investigators create a basic tool to survey alarm fatigue of intensive care staff: the first german language alarm fatigue questionnaire. the questionnaire will be collected in two phases. with the data from the first phase (n ≈ 300), the investigators aim to uncover any structure that may be latent in the questionnaire data (by exploratory factor analysis) and reduce the number of questions from 27 to \~15. the reduced questionnaire will be collected in the second phase (n ≈ 300 - 400). with the data obtained, the investigators intend to test the structure postulated in the first survey in a confirmatory factor analysis.

Eligibility criteria:
inclusion criteria: * physicians of german intensive care units * specialist nurses of german intensive care units * respiratory therapists of german intensive care units exclusion criteria: - refusal to participate
dose escalation of hypofractionated radiation therapy in patients with metastatic cancer

Conditions: Tumor; Cancer; Melanoma; Sarcoma; Carcinoma

Summary: patients with metastatic cancer are generally treated with chemotherapy, which has improved median survival compared to best supportive care. despite this, patients continue to have persistent disease at sites that were initially involved with cancer. radiation therapy is an effective modality for treating localized cancer but generally has been only used for palliation of symptoms once a patient develops metastatic disease. since patients often have persistent disease after chemotherapy, the goal of this trial is to use increasing doses of radiation therapy to all sites of involved disease in order to determine the safety and efficacy of hypofractionated radiation therapy. the purpose of this study is to establish a maximum tolerated dose, dose-limiting toxicities, and recommended phase 2 dose of hypofractionated radiation therapy.


Eligibility criteria:
inclusion criteria: * histologically or cytologically confirmed diagnosis of cancer (including epithelial carcinoma, sarcoma, and melanoma) * age 18 years and older * life expectancy of \> 3 months * patients with ajcc (6th edition, 2002) stage iv cancer with distant metastases and without pleural or pericardial effusion at diagnosis and before start of study * patients with 1-5 sites of maximum tumor dimension (for each individual site) of ≤ 10 cm or \< 500 cc volume and amenable to radiation therapy as seen on standard imaging * unidimensionally measurable disease (based on recist) is desirable but not strictly required * brain metastases must have been treated prior to enrollment on study, preferably with stereotactic radiosurgery * ecog performance status ≤ 2 or karnofsky performance status ≥ 60% * no prior radiation therapy to currently involved tumor sites * room air saturation \> 90% * hemoglobin \> 9.0 g/dl * anc \>=1,500/microliter * platelets \>=100,000/microliter * total bilirubin within institutional limits * albumin \> 2.9 g/dl * alkaline phosphatase \< 2.5x upper limit of normal * ast and alt \< 2.5 x upper limit of normal * ability to understand and willingness to sign a written informed consent document exclusion criteria: * uncontrolled intercurrent illness * patients with clinically significant pulmonary dysfunction, cardiomyopathy, or any history of clinically significant chf are excluded. exclusion of patients with active coronary heart disease will be at the discretion of the attending physician * patients with significant atelectasis such that ct definition of gross tumor volume is difficult to determine * pregnancy or breast feeding * patients must have no uncontrolled active infection other than that not curable with treatment of their cancer. * patients may not be receiving any other investigational drugs during rt

Keywords: solid tumor cancer epithelial carcinoma
outcome of rehabilitation of older people in primary health care

Conditions: Stroke; Hip Fractures; Osteoarthritis; Chronic Disease

Summary: the outcome of multi-disciplinary, structured rehabilitation of older people in a district inpatient rehabilitation centre is better than in a standard primary health care rehabilitation programme in short term beds in nursing homes.


Eligibility criteria:
inclusion criteria: * both genders * age=\>65 years * diagnoses: stroke, hip fractures, osteoarthritis, chronic, slowly progressing diseases, functional decline due to old age, functional decline due to long hospital stay * assessed to have a rehabilitation potential exclusion criteria: * age\<65 years * patietns with highly progressive diseases * sunnaas adl index\<10 * mmse\<18 * deeply depressed patients with no initiative * patients with speech dyspnoea * patients with unstable angina pectoris * patients with not diagnosed cardiac arrythmias

Keywords: rehabilitation outcome aged aged, 80 and over activities of daily living
effectiveness of adding subcutaneous long-acting glargine to insulin drip therapy compared with standard insulin drip therapy

Conditions: Diabetes

Summary: the investigators anticipate that the use of glargine will decrease the duration of an insulin drip, the dose of short-acting insulin in the drip, hospital and icu (intensive care unit) length of stay, improve glycemic control, and prevent rebound hyperglycemias when the insulin drip is discontinued.


Eligibility criteria:
inclusion criteria: * diabetic ketoacidosis (dka) and hyperglycemic hyperosmolar non-ketotic states, hyperglycemia with severe illness, pre- and postoperative states, nothing by mouth (npo), as well as gastric (tube feeding) and parenteral nutrition requiring insulin drip. * patients with type 1 and type 2 diabetes mellitus (dm) will be included. * patients with both types of diabetes will be among those treated with the insulin drip while being npo, having severe concomitant illness or receiving enteral and parenteral nutrition. * patients will be of age 19 to 80. exclusion criteria: * inability to consent for the study for any reason including cognitive impairment secondary to hyperglycemia, presence of severe medical conditions requiring intubation, severe sepsis, hypothermia, and anticipated length of insulin drip 2 weeks and longer, pregnancy, lantus allergy, and concurrent sulfonamide treatment

Keywords: diabetes
a cognitive behavioral and structural hiv prevention intervention for young ugandan sex workers

Conditions: Sexually Transmitted Infection

Summary: this study develops and tests a behavioural and structural intervention to prevent unprotected sex among young female sex workers. half the participants will receive the intervention and half will receive the standard of care.


Eligibility criteria:
inclusion criteria: * hiv-uninfected women, aged 15-24 years, being sexually active and having engaged in any form of transactional sex at least once in the last 3 months, agreeing to participate in all intervention sessions and to all study procedures and interviews planned over 18 months of follow-up. exclusion criteria: * presence of any physical or mental condition likely to cause inability to provide consent or hinder study participation; hiv infection
convalescent plasma to stem coronavirus (cssc-001)

Conditions: Coronavirus; Convalescence

Summary: evaluate the efficacy of treatment with high-titer anti- sars-cov-2 plasma versus control (sars-cov-2 non-immune plasma) in subjects exposed to coronavirus disease (covid-19) at day 28.

this randomized, controlled, double-blinded phase 2 trial will assess the efficacy and safety of anti- sars-cov-2 convalescent plasma as prophylaxis following exposure to covid-19 (as defined in the inclusion criteria). adults 18 years of age and older with high risk exposure as defined by cdc may participate. a total of 500 eligible subjects will be randomized in a 1:1 ratio to receive either high titer anti-sars-cov-2 plasma or control (sars-cov-2 non-immune plasma).

Eligibility criteria:
inclusion criteria 1. subjects must be 18 years of age or older 2. close contact exposure (as defined by cdc guidelines) to person with covid-19 within 96 hours of randomization (and 120 hours of receipt of plasma) exclusion criteria 1. receipt of any blood product in past 120 days. 2. medical, psychiatric,cognitive illness or recreational drug/alcohol use that in the opinion of the principal investigator, would affect subject safety and/or compliance. 3. symptoms consistent with covid-19 infection (fevers, acute onset cough, shortness of breath) at time of screening. 4. laboratory evidence of covid-19 infection at time of screening. 5. history or known laboratory evidence of previous covid-19 infection. 6. history of prior reactions to transfusion blood products. 7. inability to complete therapy with the study product within 24 hours after randomization.

Keywords: covid-19
efficacy and tolerability of rimegepant for the acute treatment of migraine in adults unsuitable for triptan use

Conditions: Migraine

Summary: this study is being conducted to evaluate the efficacy and tolerability of rimegepant in a population of adults that are unsuitable for triptan medications due to a previous intolerance, lack of efficacy, or contraindication (including a history of clinically-relevant cardiovascular disease).

this study is being conducted to evaluate the efficacy and tolerability of rimegepant in a population of adults that are unsuitable for triptan medications due to a previous intolerance, lack of efficacy, or contraindication (including a history of clinically-relevant cardiovascular disease). rimegepant will be further evaluated in this population with as needed use in a 12-week, open-label extension study.

Eligibility criteria:
inclusion criteria: * migraine attacks present for more than 1 year with the age of onset prior to 50 years of age. * migraine attacks, on average, lasting about 4 - 72 hours if untreated. * 4 to 14 migraine days per month on average across the 3 months prior to the screening visit (month is defined as 28 days for the purpose of this protocol). * less than 15 headache days (migraine or non-migraine) per month in each of the 3 months prior to the screening visit and throughout the screening phase. * subjects must be able to distinguish migraine attacks from tension/cluster headaches. * subjects on prophylactic migraine medication (excluding cgrp antagonists) are permitted to remain on therapy if they have been on a stable dose for at least 3 months (12 weeks) prior to the screening visit, and if the dose is not expected to change during the course of the study. * triptan unsuitable exclusion criteria: -target disease exclusion: 1. history of cluster headache, basilar migraine, or hemiplegic migraine 2. current medication overuse headaches 3. headaches occurring 15 or more days per month (migraine or non-migraine) in any of the 3 months prior to the screening visit 4. active chronic pain syndrome (such as fibromyalgia, chronic pelvic pain, complex regional pain syndrome \[crps\]) 5. other pain syndromes (including trigeminal neuralgia), dementia, or significant neurological disorders (other than migraine) that, in the investigator's opinion, interfere with study assessments of safety or efficacy

Keywords: migraine acute migraine headache acute treatment of migraine in adults unsuitable for triptans
the timing of emergency endoscopy for esophagogastric variceal bleeding in cirrhosis

Conditions: Liver Cirrhosis; Portal Hypertension; Esophageal Varix Bleeding

Summary: this study is a prospective, multi-center and observational clinical study. investigators would like to explore the optimal emergency endoscopy timing in cirrhosis patients with esophagogastric variceal bleeding (egvb) by evaluating and comparing the efficacy and safety of emergency endoscopy performed at different times ( within 6 hours or between 6 and 24 hours after gastroenterologic consultation ) and its impact on the short-term prognosis.

between july 2021 and april 2022, patients with cirrhosis undergoing emergency endoscopy due to egvb are enrolled consecutively according to the following criteria: (1) age≥18 years; (2) a definite diagnosis of cirrhosis (confirmed by medical history, laboratory examination and imaging examination); (3) the cause of bleeding was identified as esophageal and/or gastric vein rupture. exclusion criteria are as follows: (1) end-stage diseases of major organs (such as heart failure, chronic obstructive pulmonary disease, end-stage renal disease, and malignancies other than hepatocellular carcinoma); (2) the subject (or legal representative/guardian) refused to sign the informed consent. patients were divided into urgent-endoscopy group (\< 6h) and early-endoscopy group (6h-24h) according to the time interval from gastroenterologic consultation to the start of emergency endoscopy. investigators will collect patients' data of baseline character, treatment, postoperative and follow-up. all patients will be followed up until death or the end of the study.

Eligibility criteria:
inclusion criteria: * age≥18 years * a definite diagnosis of cirrhosis (confirmed by medical history, laboratory examination and imaging examination) * the cause of bleeding was identified as esophageal and/or gastric vein rupture exclusion criteria: * end-stage diseases of major organs (such as heart failure, chronic obstructive pulmonary disease, end-stage renal disease, and malignancies other than hepatocellular carcinoma) * the subject (or legal representative/guardian) refused to sign the informed consent

Keywords: esophagogastric variceal bleeding emergency endoscopy timing