Kornimate/medical-research-clean huggingface dataset:
effects of different types of exercise interventions in patients with type 2 diabetes

Conditions: Type 2 Diabetes

Summary: the purposes of the study are * to determine which kind of supervised exercise intervention (aerobic endurance training versus strength endurance training versus combined aerobic endurance and strength endurance training) is more effective in improving the metabolic parameters in typ 2 diabetes patients * to investigate what kind of intervention is more successful in reduction of concomitant diseases and improving quality of life * to assess what kind of intervention induces highest effects in long term persistence of these positive changes

meta-analyses which evaluated the effects of structured exercise programs in patients with type 2 diabetes demonstrate that regular physical activity improves glycosylated haemoglobin (könig et al.: resistance exercise and type 2 diabetes mellitus, deutsche zeitschrift für sportmedizin jahrgang 62, nr. 1 (2011): 5-9). sigal et al. proved that either aerobic or resistance training alone improved glycemic control in type 2 diabetes, but the improvements are greatest with combined aerobic and resistance training (sigal, rj, et al.: effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes, ann intern med. 2007 sep 18;147(6):357-69). therefore, aim of the current study is to compare the effects of aerobic endurance training or resistance endurance training or the combination of aerobic endurance training and resistance endurance training in diabetes type 2 patients without any other lifestyle or dietary interventions.

Eligibility criteria:
inclusion criteria: * diagnoses of type 2 diabetes (ada criteria) * admitted diabetes treatments will be diet and oral hypoglycemic agents exclusion criteria: * sports intervention \>60 minutes per week * medical conditions * preproliferative or proliferative retinopathy * instable coronary heart disease * inability to perform the scheduled physical activity programs * acute clinically significant intercurrent diseases

Keywords: aerobic training resistance training combination of aerobic and resistance training diabetes type 2 diabetes hba1c endothelial dysfunction inflammation markers parodontitis exercise intervention training
fistulectomy vs. modified karydakis procedure for pilonidal sinus

Conditions: Pilonidal Sinus

Summary: this study wants to improve patient care affected by pilonidal sinus during and after surgery. pilonidal sinus excision is a frequent procedure, despite this, there is still not an appropriate surgical technique because of a lack of quality comparative studies.

this is a randomized controlled trial. the study will compare the healing of the surgical wound and the recurrence rate after excision and primary para-median closure versus narrow orifice excision (fistulectomy) group a: excision and paramedian closure according to modified karydakis technique group b: removal / fistulectomy by scalpels or trephines of primary and drainage orifices, healing of the wound by secondary intention

Eligibility criteria:
inclusion criteria: * pilonidal cyst requiring surgery * signed informed consent form exclusion criteria: * abnormal lesions * injuries requiring a closing with rotation flap

Keywords: pilonidal sinus bascom cleft lift fistulectomy karydakis
pico- single-use negative pressure wound therapy system

Conditions: Total Ankle Arthroplasty

Summary: to compare the rate of wound complications with the pico dressing versus a standard nonstick gauze dressing in patients undergoing anterior total ankle arthroplasty.

participating subjects will be randomized to one of the study groups: group 1 (control group) or group 2 (treatment group). if randomized to group 1- after surgery, the doctor will apply the standard non-stick gauze dressing to the wound. if randomized to group 2- after surgery, the doctor will apply the pico dressing to the wound. the goal of the study is to measure the rate of wound complications based on wound assessment, patient-reported outcomes surveys, as well as peri- and post-operative data.

Eligibility criteria:
inclusion criteria: * patient ≥18 years old * subjects undergoing total ankle arthroplasty or uncomplicated revision total ankle arthroplasty * subjects able to provide informed consent * subjects who are able to understand and comply with study visit schedule and procedures exclusion criteria: * history of previous deep infection or history of wound complication necessitating plastic surgery intervention * allergy to products used in the study * pregnant and breastfeeding women due to anesthesia risks * subjects with a known history of poor compliance with medical treatment * subjects who decline participation in this research study * prisoners

Keywords: total ankle arthroplasty pico ankle ankle joint arthroplasty
the relationship between microsatellite instability and efficacy of fluorouracil based adjuvant chemotherapy in gastric cancer after operation

Conditions: Gastric Cancer

Summary: the relationship between microsatellite instability and efficacy of fluorouracil based adjuvant chemotherapy in gastric cancer after operation.

to explore the relationship between microsatellite instability and efficacy of fluorouracil based adjuvant chemotherapy in gastric cancer after operation.

Eligibility criteria:
inclusion criteria: 1. histopathology or cytopathology proven gastric cancer; 2. operable advanced gastric cancer patients: primary lesions can be completely excision, no distant metastasis; 3. postoperative patients who can tolerate 5-fu based (5-fu，s-1 or capecitabine) adjuvant chemotherapy; 4. life expectancy of at least 6 months; 5. ecog（eastern cooperative oncology group ） score 0-1; 6. age: 18\~80 years old; 7. normal hemodynamic indices before the recruitment (including blood cell count and liver/kidney function). * for example: wbc（white blood cell count ）\>4.0×109/l; neu（neutrophils）\>1.5×109/l; plt（platelet）\>100×109/l; 8. roughly normal cardiopulmonary function: no coronary heart disease, myocardial infarction, pulmonary heart disease, refractory hypertension; 9. not concomitant with other uncontrollable benign diseases before the recruitment; 9. voluntarily signed the informed consent. exclusion criteria: 1. advanced gastric cancer patients with distant metastasis and inoperable ; 2. patients who cannot tolerate 5-fu based adjuvant chemotherapy; 3. pregnant or lactating women; 4. patients who have no desire to participate in the study.

Keywords: microsatellite instability fluorouracil adjuvant chemotherapy efficacy operation
optimizing iron status while minimizing morbidity in hiv-infected ugandan children

Conditions: Anemia; Iron-deficiency; Iron Deficiency Anemia; Hiv

Summary: randomized, placebo-controlled trial of the effect of 84 days of daily iron supplementation on iron status, gut microbiome profile, infectious disease frequency, and hiv disease severity in moderately anemic \[hemoglobin 9 - \<11 g/dl (6-59 mo); hemoglobin 9 - \< 11.5 g/dl (5 -12 years)\], hiv-infected ugandan children between the ages of 6 mos and 12 years.


Eligibility criteria:
inclusion criteria: 1. confirmed diagnosis of hiv (based jcrc clinic records); 2. on highly active antiretroviral treatment (haart) for ≥ 6 months 3. age 6 months - 12 years at the time of screening 4. hemoglobin 9 - \<11 g/dl (6-59 mo); hemoglobin 9 - \< 11.5 g/dl (5 -12 years)by cbc at time of screening exclusion criteria: 1. acute illness or current opportunistic infection 2. temperature \>= 38.0°c at the time of screening 3. known sickle cell disease 4. acute malnutrition (bilateral pitting edema or extreme wasting) 5. any chronic illness requiring regular medical attention 6. residence \> 50 km from jcrc hospital 7. non-english or luganda speaking 8. currently taking iron supplements
blinatumomab maintenance after allo-hsct

Conditions: High Risk Acute Lymphoblastic Leukemia

Summary: to evaluate the safety and efficacy of blinatumomab maintenance after allogeneic hematopoietic stem cell transplantation for high-risk acute b-lymphoblastic leukemia.

blinatumomab is a novel immunological antibody based on bite. cd19 is a surface antigen expressed throughout the development of b lymphocytes, making it an ideal target for immunotherapy. blinatumomab was approved by the fda for the treatment of adults with relapsed/refractory cancers. open-label, single-arm, multicenter phase ii clinical study (blast study) , enrolling 116 adult patients with precursor b-all in complete hematologic remission after at least 3 doses of intense chemotherapy but persistently positive for measurable residual disease (mrd) (mrd ≥10-3 ), which is the first all international multicenter clinical trial. in august 2022, china's national medicines and pharmaceutical administration (nmpa) approved blinatumomab for the treatment of relapsed/refractory precursor b-cell all in adults. blinatumomab is mostly used for preemptive therapy after post-transplant mrd conversion, and fewer prospective studies have been conducted in the area of maintenance therapy. a prospective single-arm clinical study (nct02807883) with blinatumomab as maintenance therapy (up to 4 cycles) after allogeneic transplantation, concluded by md anderson in august 2021, had the primary endpoints of safety (acute graft-versus-host disease \[agvhd\] and non-relapse mortality \[nrm\]) and the secondary endpoints of efficacy (pfs, os, etc.), a total of 23 patients were enrolled in patients who received at least 1 cycle of blinatumomab, the interval between transplantation and the first cycle of blinatumomab use was 78 days (44-105), 57% of the patients completed 4 cycles of treatment, the median follow-up was 14.3 months, the 1-year nrm was 0%, the incidence of grade 3-4 agvhd was 5%, the 1-year os was 85%, and the 1-year pfs was 71%. there was a trend toward benefit in pfs and os curves between the two groups. although this study is an exploratory study, data from applied studies in the post-transplantation maintenance phase suggest that this immunotherapy may be termed as a new, better and safer option. therefore, the investigators conducted a multicenter, randomized, controlled study based on retrospective research to further explore and validate the safety and efficacy of blinatumomab as a maintenance therapy after high-risk b-all allogeneic transplantation.

Eligibility criteria:
inclusion criteria: 1. age 16-65 years 2. diagnosis with acute b-lymphoblastic leukemia (b-all) expressed cd19 3. high-risk group b-all 4. have suitable hematopoietic stem cell donors 5. no dysfunction of vital organs exclusion criteria: 1. cr/mrd negative before blinatumomab maintenance 2. active hepatitis b 3. hiv-infected 4. active infections; acute and chronic gvhd requiring systemic immunosuppressive therapy; 5. severe impairment of vital organ function 6. those judged by the investigator to be unsuitable for participation in this trial.
filgotinib in combination with methotrexate in adults with moderately to severely active rheumatoid arthritis who have an inadequate response to methotrexate

Conditions: Rheumatoid Arthritis

Summary: the primary objective of this study is to evaluate the effects of filgotinib versus placebo for the treatment of signs and symptoms of rheumatoid arthritis (ra) as measured by the percentage of participants achieving an american college of rheumatology 20% improvement response (acr20) at week 12.


Eligibility criteria:
key inclusion criteria: * have a diagnosis of rheumatoid arthritis (ra) \[2010 american college of rheumatology (acr)/european league against rheumatism (eular) criteria\] , and are acr functional class i-iii. * have ≥ 6 swollen joints (from a swollen joint count based on 66 joints (sjc66)) and ≥ 6 tender joints (from a tender joint count based on 68 joints (tjc68)) at both screening and day 1. * ongoing treatment with a stable dose of mtx key exclusion criteria: * previous treatment with any janus kinase (jak) inhibitor note: other protocol defined inclusion/ exclusion criteria may apply.
relationship between kinesiophobia, physical activity and disability level and pain management in patients with clbp

Conditions: Low Back Pain

Summary: the aim of this study was to examine the relationship between pain management, kinesiophobia, physical activity and disability level in patients with chronic low back pain (clbp) in different genders. eighty-two patients with clbp (42 females, 42 males) between the ages of 20-60 participated in the study. pain management strategies were determined by pain coping questionnaire (pcq). tampa scale for kinesiophobia for perception of kinesiophobia, oswestry disability index for disability due to pain and international physical activity questionnaire-short form (ipaq-sf) for the physical activity level were used.


Eligibility criteria:
inclusion criteria: * individuals who are between 20 and 60 years old, * experienced low back pain lasting longer than 3 months, and had no problems with reading, writing, and comprehension were included in the study. exclusion criteria: * individuals who underwent surgery for low back pain, * had any diagnosed spinal problem, * who were pregnant, * and who had communication problems were not included in the study.

Keywords: pain management kinesiophobia physical activity disability
the role of mucosal associated invariant t lymphocytes in breast cancer

Conditions: Breast Cancer

Summary: evaluation of mait cells in patient recently diagnosed as cancer breast and its correlation with clinical outcome. mucosal associated invariant t cells are a population of unconventional t cells which are enriched in mucosal tissues such as the lung and gut but are also present in other tissues including the skin, adipose tissue and the liver \[4,5,6,7\]. unlike conventional t cells, mait cells are not restricted by mhc but recognize the mhc-related protein mr1. mait cells express a semi-invariant tcr α-chain (vα7.2-jα33/20/12 in humans) and a limited repository of tcr-β chains, mostly from the trbv20 and trbv6 gene families \[8,9\] mait cells can also be activated independent of tcr engagement, via pro-inflammatory cytokines such as il-18 \[10,11,12\]. upon activation, mait cells can rapidly respond, producing a milieu of cytokines including interferon-gamma , tumor necrosis factor alpha and interleukin-17 \[11,14\]. mait cell cytokine profiles can vary depending on their tissue localization \[15\]. peripheral mait cells are potent producers of ifnγ and tnfα, whereas il-17 producing mait cells are rare in the periphery but are more abundant in, for example, the female genital mucosa \[16\]. in addition to cytokine production, a central role in immune protection against cancer is played by t lymphocytes, particularly cd8+ t cells .their infiltration in tumor cell nests is usually associated with a favorable prognosis and may predict outcome of therapies with drugs that block immune inhibitory receptors (checkpoint blockade. a recent meta-analysis reported that tumor-infiltrating cd8+ lymphocytes can be identified in 48% of all breast cancers .interestingly, triple-negative breast cancers show the highest incidence of lymphocyte predominance. moreover, tils were found to be prognostic in triple-negative breast cancer, and higher levels of tils were predictive for trastuzumab benefit in her2+ disease. these findings suggest that therapies that enforce immune responses could potentially improve patient survival.


Eligibility criteria:
inclusion criteria: * female patients admitted at south egypt cancer institute who diagnosed as breast cancer based on full clinical, radiologic and pathologic assays exclusion criteria: 1. patients receive any anti-cancer therapy. 2. patients diagnosed with other concomitante cancer or chronic disease
anastomotic leak testing in gastrectomy

Conditions: Anastomotic Leak; Gastric Cancer; Surgery; Testing, Reality; Gastroscopy

Summary: anastomotic leak after radical gastrectomy is a serious complication. intraoperative leak testing was often used to assess the integrity of the anastomosis. however, the reliability, clinical benefits and safety of intraoperative leak testing are controversial. our aim is to evaluate the effect and safety of intraoperative leak testing, and to compare the surgical complications of patients in intraoperative leak testing group with patients in non-intraoperative leak testing group.

anastomotic leak after radical gastrectomy is a serious complication. intraoperative leak testing was often used to assess the integrity of the anastomosis. however, the reliability, clinical benefits and safety of intraoperative leak testing are controversial. our aim is to evaluate the effect and safety of intraoperative leak testing, and to compare the surgical complications of patients in intraoperative leak testing group with patients in non-intraoperative leak testing group. patients underwent total gastrectomy for gastric cancer, with esophagojejunostomy reconstruction.

Eligibility criteria:
inclusion criteria: 1. resectable gastric carcinoma according to the eighth edition of the tnm (clinical stages i-iii). 2. eastern cooperative oncology group performance status of 0 or 1. 3. american society of anesthesiologists class of i-iii. exclusion criteria: 1. patients had distant metastasis. 2. presence of obvious contraindications to surgery (e.g., liver and/or kidney function abnormalities). 3. any participation in another clinical trial within the past 6 months. 4. previous chemotherapy or radiation therapy for any other malignancies. 5. past history of gastric resection, gastric cancer-related complications, other malignancy diagnosed within the previous 5 years,

Keywords: anastomotic leakage gastric cancer leakage testing total gastrectomy gastroscopy
activity scheduling for older adults with dementia

Conditions: Older Adults With Mild to Moderate Level of Dementia

Summary: this study is to evaluate the results from an intervention designed to encourage older adults with dementia for their engagement in activities through their active participation of activity scheduling (as).

the study compares two interventions by using a 12-week longitudinal randomized controlled trial. for the first 2 weeks, all participants receive the same health care education program. then for the following 10 weeks, participants will be randomized to either one of the two following groups with different conditions. for the control group, participants receive ten session of dementia care education. for the experimental activity scheduling group, participants receive ten session of dementia care education, plus weekly activity scheduling (as) practice that focus on pleasant event scheduling and improving communication.

Eligibility criteria:
inclusion criteria: * patients had to have an age of at least 65 years, * a diagnosis for dementia in medical history and had to meet international classification of disease-10 criteria for dementia, * diagnosed by a psychiatrist. * patients had to have cognitive impairment, as determined by the montreal cognitive assessment exclusion criteria: * any major neurological illness other than ad, * any psychiatric disorder or a known history of substance abuse.
changes in qol and symptoms in patients with polycythemia vera receiving ruxo in a routine clinical practice

Conditions: Polycythemia Vera

Summary: the purpose of this multicenter observational prospective cohort study is to examine changes in qol and symptoms in patients with polycythemia vera (pv) during treatment with ruxolitinib (ruxo), and to evaluate efficacy and safety of ruxo in a real-world setting


Eligibility criteria:
inclusion criteria: * patients who have confirmed diagnosis of pv * patients whose age - 18 years and older * patients who signed informed consent * patients who able to fill out questionnaires exclusion criteria: * patients enrolled in clinical trials * patients with contraindications to ruxo in accordance with instruction for use

Keywords: ruxolitinib quality of life
utility of biparametric mri (magnetic resonance imaging) as a screening tool for prostate cancer in a high-risk cohort

Conditions: Prostate Cancer; Magnetic Resonance Imaging; Population at Risk

Summary: to determine whether using bpmri in subjects who are at high risk of developing prostate cancer in conjunction with psa will improve prostate cancer screening protocols.

the investigators propose a pilot study which utilizes bpmri in conjunction with psa in the early detection of clinically significant prostate cancer in a high-risk group. our study would focus on these high-risk subjects between the ages of 40-55 with a normal psa ranging from ≥1.0 to \<2.5 ng/ml. bpmri would be obtained in this group of subjects. if any suspicious lesions are found, the recommendation is to undergo mri/us fusion biopsy. subjects with negative bpmri will be followed every year with serum psa. subjects with a positive bpmri will have a prostate fusion and systematic biopsy performed. those with a benign biopsy will be followed every year with serum psa. those who have a biopsy positive for cancer will be managed and followed according to the standard of care. all subjects will be followed for 5 years. our hypothesis is that bpmri in conjunction with above average psa in a high-risk group will increase detection of clinically relevant prostate cancer and provide a useful addition to psa screening.

Eligibility criteria:
inclusion criteria: 1. psa between 1.0 and 2.5 ng/dl 2. high risk for prostate cancer, i.e. black or they have a first degree relative with history of prostate cancer (father, brother) or specific genetic syndromes i.e. brca 1/2, hox b13, lynch syndrome, atm, chek2 3. patient is willing to participated in prostate cancer screening 4. patient is capable of giving informed consent exclusion criteria: 1. nodularity or firmness of prostate on exam 2. patient has undergone a prior biopsy or prostate surgery 3. patient is taking 5-alpha reductase inhibitors to manage benign prostatic hyperplasia, as this can significantly alter psa levels. 4. patient has a history of uti or prostatitis in the preceding 6 months, as this can significantly alter psa levels. 5. patient has a contraindication to mri, these include but are not limited to pacemakers, neurostimulator devices, metal cardiac valves, certain tattoos, or foreign bodies 6. participants that experience claustrophobia, anxiety and/or vertigo when moved inside the scanner 7. the participant cannot tolerate lying flat for the study duration

Keywords: prostate cancer screening magnetic resonance imaging