Kornimate/medical-research-clean huggingface dataset:
evaluating sprc-ab01 in post-surgical subjects with chronic sinusitis

Conditions: Chronic Sinusitis

Summary: the primary objective of the study is to evaluate the safety and efficacy of sprc-ab01 versus placebo for treatment of chronic sinusitis in subjects who have had sinus surgery.


Eligibility criteria:
inclusion criteria: * outpatient subjects who have signed a written informed consent. * a documented history of chronic sinusitis with clinical signs and symptoms suggestive of inflammation or infection for at least 90 consecutive days. * a documented history of sinus surgery \> 90 days. * nasal endoscopic exam documenting purulence (pus) from an open sinus cavity with mucosal swelling/edema. * women of childbearing potential must have a negative serum pregnancy test and must use adequate birth control throughout the study. exclusion criteria: * pregnant females and females unwilling to use adequate birth control. * use of any investigational drug/device within 30 days of study screening. * the following medications will require a certain washout period as determined by the protocol: systemic corticosteroids, mast cells and/or leukotriene inhibitors, anti-inflammatories, decongestants, antihistamines, non-steroidal anti-inflammatory (nsaid) or cyclooxygenase (cox)-2 inhibitors, antibiotics or antifungals. * presence of other infections which may require use of systemic antibiotics. * known allergy or hypersensitivity to aminoglycosides or other study drug formulation components. * recent hospitalization for any reason and/or major surgeries within 30 days of study screening. * major elective and/or nasal and/or sinus surgical procedures (including sinuplasty) within 90 days before or 90 days after study screening. * known history of neurological or muscular disorders. * diagnosis of an immunodeficiency disease. * previous diagnosis of cystic fibrosis, ciliary dyskinesias, kartagener syndrome, empty nose syndrome, wegener granulomatosis, churg-strauss syndrome, samter syndrome, or sarcoidosis. * current or known history of tinnitus, vertigo, or significant sensorineural hearing loss. * recent history of alcohol or drug abuse. * inability to understand the nature, scope, and possible consequences of the study or study procedures, unless cared for by a legally authorized representative. * inability to adhere to the study requirements. * previous participation in any naryx pharma protocol.

Keywords: chronic sinusitis
nutrition for trauma community survey

Conditions: Psychological Trauma, Historical; Nutrition; PTSD - Post Traumatic Stress Disorder

Summary: the survey will help investigators learn everything about how people view and respond to trauma from a holistic perspective through body (nutrition), mind (mental health rejuvenation and renewal), and spirit (faith-based) lens. researchers aim to evaluate if such practices will be effective in helping participants with significant life challenges due to trauma, negative life events, or extremely stressful events will recover from these types of lifestyles. the responses will be used to shape the integrative protocols that the investigators develop for professionals involved with trauma clients. this can help increase recovery rates and lead to productive lives.

what is the purpose of this study? the study is being done to answer the following question: can lack of body-mind-spirit practices heighten psychological trauma and is lack of these practices increased in this population? the survey will help the investigators learn everything about how people view and respond to trauma from a holistic perspective through body (nutrition), mind (mental health rejuvenation and renewal), and spirit (faith-based) lens. researchers aim to evaluate if such practices will be effective in helping participants with significant life challenges due to trauma, negative life events, or extremely stressful events will recover from these types of lifestyles. the responses will be used to shape the integrative protocols that the investigators develop for professionals involved with trauma clients. this can help increase recovery rates and lead to productive lives. what is required? this survey will ask questions related to demographics, past traumatic events, levels of stress, dietary habits, self-care practices, and beliefs surrounding holistic wellness.

Eligibility criteria:
inclusion criteria: * any one not listed in exclusion criteria that is over 18 years of age exclusion criteria: * must not be a prisoner * must not be pregnant * must not be under 18 years old

Keywords: psychological trauma nutrition body-mind-spirit ptsd - post traumatic stress disorder survey
impact of alpha-lipoic acid ingestion on glucose tolerance in subjects with pre-diabetes

Conditions: PreDiabetes

Summary: obesity, with a prevalence of over 35% in american adults, is considered the most critical threat to the health and well-being of americans. obesity-associated metabolic abnormalities, including hyperglycemia, insulin resistance, and dyslipidemia, contribute substantially to elevated risk of cardiovascular disease (cvd) and diabetes. although significant and sustained lifestyle modifications in diet and exercise are effective in reducing weight and improving obesity-related metabolic disturbances, long-term compliance to drastic changes in diet and daily activity patterns is often difficult to attain given the hectic lifestyle of modern societies. health-promoting nutraceuticals - naturally occurring bioactive compounds capable of eliciting targeted molecular responses at the cellular level - may be an effective and convenient strategy to assist in weight reduction and reduce disease risk factors in obese individuals. furthermore, nutraceutical compounds could prove to be a powerful adjunct to lifestyle and pharmacological weight reduction therapies, as they are relatively safe, cost effective, and possess the ability to modulate specific, and sometimes multiple, molecular targets. as a dietary supplement, alpha-lipoic acid appears to have broad molecular specificity with an impressive array of metabolic health benefits that include weight loss, reduction in blood lipids, and improved glycemic control. as the effects of alpha-lipoic acid supplementation for dyslipidemia, hyperglycemia, and body composition through appetite suppression and increased energy expenditure have been repeatedly confirmed in multiple animal models, it is surprising that there has been limited effort to translate these responses to human subjects. given the strong pre-clinical data supporting the health benefits of alpha-lipoic acid, there is a clear need to conduct controlled interventions to address the current clinical knowledge gap and assess if the anti-diabetic effect of α-lipoic acid can be translated to humans. the primary objective of this application is to determine the efficacy of alpha-lipoic acid supplementation on glycemic control and body composition in obese pre-diabetic adults. the investigators hypothesize that alpha-lipoic acid supplementation will improve biomarkers of diabetes and cardiovascular risk and promote changes in body composition in obese adults.


Eligibility criteria:
inclusion criteria: * sedentary individuals (exercises \< 2 days/week) * fasting blood glucose between 100-125 mg/dl (pre-diabetes) * bmi of 25-40. exclusion criteria: * physically active lifestyle (exercise \> two days/week) * pregnancy * history of cigarette smoking * medication and/or dietary supplement to control blood glucose, lipids, or blood pressure.

Keywords: pre-diabetes glucose insulin blood lipids alpha lipoic acid
intraoperative tiva with propofol on postoperative pain and side effects after liver resection surgery

Conditions: Postoperative Pain

Summary: postoperative pain can be severe after liver resection surgery. however, postoperative pain management may be difficult for this group of patients. opioidergic neurotransmission may be altered in cirrhotic patients and selectively increasing receptor affinity for opioids. large dose of strong opioid may be required to achieve adequate pain control. however, this may not be possible due to the side effect of opioid and liver dysfunction after liver resection. propofol is a commonly used anaesthetic with rapid recovery and less side effects and tiva (total intravenous analgesia) with propofol is a common technique now. the reduction on certain serum pro- inflammatory cytokines may lead to more smooth post- surgical recovery. recent case report proved the analgesic effect of propofol infusion. however other animal and clinical studies showed controversial result. the aim of this retrospective study is to investigate the postoperative analgesic effects and side effects of intraoperative tiva with propofol in patient undergoing liver resection surgery at queen mary hospital, hong kong between 2010 to 2012.

retrospective audit. anaesthetic records and acute pain service records of patient undergone liver resection surgery between 2010 to 2012 in queen mary hospital would be retrieved from the computer. data collection 1. demographic data; 2. types of analgesic techniques; 3. type of pain relief modalities; 4. pain score up to 72 hours postoperatively; 5. postoperative opioid consumption; 6. incidence of adverse events during aps care; 7. patients' satisfaction on pain relief. data analysis for summarising analysis, mean or median with standard deviation or interquartile range will be reported. parametric and non-parametric comparative tests will be used for analysis between/among patients with various characteristics. kaplan meier survival analysis and log-rank test will be used for duration of aps use.

Eligibility criteria:
inclusion criteria: * patient undergone liver resection surgery between 2010 to 2012 in queen mary hospital exclusion criteria: * essential data were missing. * patient participating in other research projects. * changes in postoperative pain management technique. * patients could not be assessed post-operatively for pain (i.e. post-operative ippv)

Keywords: tiva propofol postoperative pain liver resection surgery retrospective study
investigation of non-invasive outcomes predictors in patients undergoing dbs for movement disorders

Conditions: Movement Disorders

Summary: the purpose of the study is to determine if non-invasive measurements of brain waves from the skin called electroencephalography (eeg) can predict whether the brain stimulator will help your symptoms. our goal is to obtain these brain wave measurements with patients both awake and under general anesthesia, and then to evaluate which brain wave patterns are associated with clinical improvement to determine if they could be useful for predicting whether the surgery will work. if such predictive measures were established based upon the findings of this study, they could be used in the future to improve surgical outcomes in the following ways: (1) to help guide surgical targeting in the operating room awake or under anesthesia, (2) to guide post-operative programming in clinic, and (3) and to develop potential feedback systems for "automatic" programming of the brain stimulator system at home.


Eligibility criteria:
inclusion criteria: 1. patients who elect to undergo deep brain stimulation as part of routine clinical care for movement disorders (parkinson's disease, essential tremor, dystonia, tourette's syndrome). 2. adults, ages 19 and older exclusion criteria: 1. patients who are outside the age range for inclusion 2. patients who are unable to consent to the research for cognitive or behavioral reasons 3. patients who are medically too ill to participate, and 4. patients who have their dbs programming at outside facilities

Keywords: deep brain stimulation
evaluation of the efficacy and safety of recombinant human growth hormone (rhgh) in the treatment of children with short bowel syndrome

Conditions: Short Bowel Syndrome

Summary: this is a randomized controlled, parallel group, open label versus "no treatment" trial which evaluate the efficacy of rhgh on weaning off parenteral nutrition in children with short bowel syndrome.the total follow-up is 14 months; 4 months for each group after randomization; at the end of the first four months: the treated group will be followed within 6 months, the untreated group will receive compassionately rhgh for 4 months and followed-up for 6 months after the end of the treatment period.


Eligibility criteria:
inclusion criteria: age 3-18 year with a bone age test under 18-year children with short bowel syndrome and intestinal insufficiency, the remaining bowel length should be under 80 cm after the first post-surgical period. parenteral nutrition dependency: under parenteral nutrition for at least 3 years with parenteral glycolipidic diet \> or = 30% of the total caloric need for age. the parenteral diet should have been stable for at least 3 months. parents consent exclusion criteria: over 20% change in caloric daily requirement within the last 6 months before inclusion. surgery on digestive tube within the last 3 months. administration of drugs targeting digestion (decontamination, macrobiotic, gastric dressing, chelating agents of biliary salts) within the last month. history or presence of tumoral process, leukaemia, minor intracranial hypertension, epiphysiolysis, carpal tunnel syndrome. ongoing infection (fever and inflammatory biologic syndrome), progressive inflammatory syndrome. heart failure, renal and respiratory insufficiency. allergy to solvent. any condition making impossible the follow-up of the patient during the study. person participating in another clinical trial or taking another medication under investigation within one month before inclusion.

Keywords: short bowel syndrome growth hormone children
feasibility and effectiveness of a specific app to delivery mindfulness sessions

Conditions: Migraine; Neuropathic Pain

Summary: a standardized behavioural approach based on mindfulness delivered mainly by a specific app on android will be developed and applied for patients with chronic pain conditions, as migraine and neuropathic pain. the aim of this pilot study: the investigators propose a pilot study to enforce the application of a home-program for patients with different pain conditions, to learn mindfulness practice, added to a regular mindfulness guided face-to-face program, by using the technology with android to receive mindfulness sessions for daily practice and to assess the feasibility and the effectiveness of behavioural approach base on mindfulness delivered with this modality.

background and significance different clinical experiences confirmed the effectiveness of interventions based on the application of standardized behavioural approaches to support pharmacological traditional treatments for pain conditions in the last decades. also, different clinical experiences were performed by using electronic devices to deliver home-sessions of behavioral approach (mindfulness) to patients that can practice regularly and supported by mindfulness recorded sessions the aspect of feasibility of these treatments is not reported in published studies, but it can be estimated that standardized behavioural therapies are used in helping patients to obtain a better outcome for pain management in particular, the use of technology to deliver behavioral exercises to patients suffering from different pain conditions, as neuropathic pain and migraine, have been reported in the literature of the last decades. exercise-based on telemedicine and smartphone applications seem appropriate, as they have been recently tested in the management of chronic pain conditions to reinforce the efficacy of pharmacological therapies and to teach patients to manage their pain and to be more conscious about their clinical condition and about the use of drugs.

Eligibility criteria:
inclusion criteria: * diagnosis of neuropathic pain and chronic migraine * written informed consent exclusion criteria: * co-existent severe medical or psychiatric illnesses, documented by specific previous diagnoses * seizures * use of opioids
evaluation and further development of an artificial intelligence-based algorithm for clinical decision support

Conditions: Invasive Mechanical Ventilation

Summary: invasive mechanical ventilation is one of the most important and life-saving therapies in the intensive care unit (icu). in most severe cases, extracorporeal lung support is initiated when mechanical ventilation is insufficient. however, mechanical ventilation is recognised as potentially harmful, because inappropriate mechanical ventilation settings in icu patients are associated with organ damage, contributing to disease burden. studies revealed that mechanical ventilation is often not provided adequately despite clear evidence and guidelines. variables at the ventilator and extracorporeal lung support device can be set automatically using optimization functions and clinical recommendations, but the handling of experts may still deviate from those settings depending upon the clinical characteristics of individual patients. artificial intelligence can be used to learn from those deviations as well as the patient's condition in an attempt to improve the combination of settings and accomplish lung support with reduced risk of damage.


Eligibility criteria:
inclusion criteria: • subjects who are 18 years or older and receive invasive mechanical ventilation for \> 4 hours exclusion criteria: • patients receiving one-lung ventilation

Keywords: mechanical ventilation ventilator-induced lung injury ards artificial intelligence
therapeutic vaccine based on adc1 dendritic cells for the control of viremia after ati in hiv infected individuals

Conditions: HIV Vaccine

Summary: the goal of this interventional study is to validate the strategy of adjuvant therapy with dendritic cells in hiv infection in chronically infected individuals. the main questions it aims to answer are related to the safety and tolerance of the intervention and the virological and immunological impact of immunotherapy with adc1 in hiv-infected individuals. the study will include 30 diagnosed hiv-infected patients, using antiretroviral therapy, who will be immunized with adc1 or placebo according to the arms of this study: g1) placebo; g2) adc1immunization; g3) adc1 immunization with analytical treatment interruption of art.

dendritic cell based immunotherapy is a potential tool to stimulate a specific immune response, as a complementary treatment for hiv-infected individuals using art. polarizing dcs are capable to produce high levels of il-12p70 and induce a strong cytotoxic response that is very useful in viral infections. in this context, we propose to study adc1 pulsed with relevant hiv peptides for treatment of hiv infected individuals. the study will include 30 diagnosed hiv-infected patients, using antiretroviral therapy, who will be immunized with adc1 or placebo according to the arms of this study: g1) placebo; g2) adc1immunization; g3) adc1 immunization with analytical treatment interruption of art. autologous pbmcs will be collected for baseline parameters and vaccine will be inoculated in 3 doses (with 4 week interval). three weeks after 3th vaccine inoculation, patients will be followed for 6 months and blood and biopsis samples will be collected for different parameters measurement as immune activation, immunogenicity, humoral response, mucosal cellular immunity and virologic profile and viral reservoir analysis.

Eligibility criteria:
inclusion criteria: * hiv infection confirmed according to the criteria of the department of chronic diseases and sexually transmitted infections of the brazilian health ministry; * absence of the use of antineoplastic or corticosteroid therapies for a minimum period of six months prior to study entry; * absence of comorbidities considered uncontrolled by researchers; * viral load ≤ 40 copies/ml, stable (i.e., no \> 0.5 log) in the six months prior to the start of the study; * blood count of cd4 t lymphocytes ≥ 500 cells/μl, stable (i.e., \>25%) in the six months prior to the start of the study; * informed consent exclusion criteria: * individuals without adequate venous access to the blood collection and apheresis procedure; * use of drugs or alcohol in a way that interferes with patients' ability to follow the study requirements; * pregnancy, breastfeeding or interest in becoming pregnant during the study period; * presence of any other condition that, in the evaluation of researchers is able to promote alteration of the immune system, as well as any disorders that could affect understanding in the process of informed consent.

Keywords: hiv immunotherapy polarizing dendritic cells
effectiveness and safety of rhubarb for the treatment of patients who have suffered from cerebral hemorrhage

Conditions: Lung Infection; Cerebral Hemorrhage; Pneumonia

Summary: this study will determine if rhubarb will reduced the incidence of pneumonia and improved recovery from an acute cerebral hemorrhage. the study is designed to look at both infection rate and overall recovery and recovery of motor function, for example muscle strength and coordination.


Eligibility criteria:
inclusion criteria: * occurrence of an acute cerebral hemorrhage (between 9 and 72 h after onset) with a score of at least 6 on the national institute of health stroke scale (nihss), and patient age of at least 18 years. * have no pneumonia according to modified criteria of the u.s. centers for disease control and prevention (cdc) * consistent with the constipation of phlegm-heat accumulation type by traditional chinese medicine (tcm) standard * patients or their representatives voluntarily take part in this study and signed the informed consent exclusion criteria: * cerebral infarction, transient ischemic attack(tia) * subarachnoid hemorrhage * proven cerebral embolism caused by tumor, brain trauma, cerebral parasitic disease, dysbolismus, fibrillation atrial resulted from rheumatic heart disease, coronary heart disease, and other heart diseases * clinical signs of infection on admission * pregnant or breast-feeding * allergic to rhubarb * preceding or ongoing antibiotic therapy within the last 24 h * participation in another interventional trial * immunosuppressant treatment within the last 30 days * combining severe clinical conditions such as liver, kidney, hematopoietic system, endocrine system or psychological diseases

Keywords: lung infection after cerebral hemorrhage prevention of pneumonia rhubarb