Kornimate/medical-research-clean huggingface dataset:
serum cd14 and cd88 mointoring in icu

Conditions: Sepsis

Summary: the present study will be conducted to determine the dynamic changes of serum soluble cd14 and the corresponding changes of serum cd88 and their correlation in critically ill sepsis and sirs patients.

a total of ninty four will be included in the study. forty seven patients are critically ill with evidence of sepsis during icu stay (sepsis group) and forty seven patients are critically ill without evidence of infectious organism (sirs group). at admission, patients data include clinical status; sofa score; central venous pressure; laboratory analysis and arterial blood gas analysis are measured. routine cultures will be obtained. the attending physician will evaluate the patients for sepsis, severe sepsis, or septic shock as long as their stay in icu. a serum level of cd 14 and cd88 will be monitored.

Eligibility criteria:
inclusion criteria: * the patients staying in icu for more than 24 hours will be included in the study. exclusion criteria: * patients received anti-inflammatory drugs or corticosteroids before admission, patients had immunosuppressive illness, patients had chronic organ failure; patients received massive blood transfusion; patients with radiation therapy and patients with previous organ transplantation will be excluded from the study.

Keywords: soluble cd14 ,serum cd88,sepsis , sirs.
assessment of low energy lens fragmentation cataract extraction in patients undergoing cataract surgery

Conditions: Cataract

Summary: the purpose of this research study is to evaluate the clinical outcomes of the use of low-energy segment removal with a micro-interventional irrigation/aspiration port (micor-304) to evacuate the lens prior to intraocular lens insertion in subjects undergoing routine cataract surgery.

up to 300 eyes at up to 5 investigational sites will be enrolled in one of the two cohorts of this clinical investigation - up to 50 eyes in cohort 1 and up to 50 eyes in cohort 2. only one eye per subject will be enrolled into the study. this is multicenter, multi-cohort, prospective clinical study designed to provide longitudinal, observational, non-comparative clinical outcome data for mechanical non-phacoemulsification lens extraction using low-energy segment removal with a micro-interventional irrigation/aspiration port (micor-304) to evacuate the lens prior to intraocular lens insertion. participants who meet the inclusion and exclusion will be asked to enroll in the study. the investigator or designee will explain the study purpose, procedures and responsibilities to the potential participant and provide sufficient opportunity to ask questions, while allowing adequate time for consideration of the information provided. upon participant confirmation of interest, written informed consent will be obtained and the subject will be enrolled in the study. one copy of the informed consent document (icd) will be retained with the subject's medical records and one copy will be provided to the subject. study subjects will be stratified into two cohorts. cohort 1 is comprised of eyes with mild-to- moderate cataracts only (grade 1 to 2). cohort 2 is comprised of eyes with moderate to more dense cataracts only (grade 2+ to 3+). subjects will be seen at the screening visit, intraoperative visit, and at post-operative days 1, 7, and 30.

Eligibility criteria:
inclusion criteria: 1. able to understand study requirements, willing to follow study instructions and willing to return for required study follow-up visits 2. willing and able to understand and complete the informed consent document 3. subjects with a cataract grade of 1 to 3+ and are scheduled to undergo cataract surgery 4. subjects ≥ 18 years of age 5. clear intraocular media, other than cataract exclusion criteria: 1. polar cataracts 2. zonular instability 3. history of dry eye treatments/devices and or dry eye medications other than artificial tears. 4. concurrent participation or participation in any clinical trial up to 30 days prior to preoperative visit 5. subjects that are pregnant, lactating or planning to become pregnant during the course of the study
clubfeet and twins and gait analysis

Conditions: Clubfoot

Summary: children with clubfeet who were exclusively treated by ursula issler-wüthrich for 3 to 14 years with manual-dynamic physiotherapy and their healthy twin siblings are compared using gait analysis. gaitup sensors (kinematic) and footscan v9 (kinetic) are the systems used for this comparison. nonparametric statistics are applied to verify aberrations.

control gait analysis in clubfoot children and comparison with their healthy twins clubfeet are the most common birth defect with about 80 cases in switzerland per year. there are two important therapies: ponseti and manual-dynamic physiotherapy. ursula issler-wüthrich, physiotherapist, since twenty years treats exclusively clubfeet and comorbidities with clubfeet like arthrogryposis and myelomeningocele. until today she corrected more than 400 feet with manual-dynamic physiotherapy. among her patients there are 11 twin pairs. in the scientific literature it is stated that in unilateral clubfoot, the other foot cannot be considered normal.with the two gait analysis systems meant for controlling the therapy results, the walking pattern of the healthy twin was compared with the pattern of the affected twin sibling. the basis of the study is a walk over 25 meters with the gaitup sensors (11 g) resulting in 22 quantitative digital parameters and tests on the pedobarographic plate footscan v9 leading to 10 parameters. statistically it will be analyzed whether there is a discrepancy between the clubfeet children and their healthy twins. the parents in writing and the children orally gladly approved the task.

Eligibility criteria:
inclusion criteria: * twins with clubfeet exclusion criteria: * all other clubfeet

Keywords: clubfoot gait analysis twin comparison inertial sensor footscan manual-dynamic physiotherapy derotation
the relationship between epicardial fat tissue and cardiac function in hfpef patients

Conditions: Heart Failure With Preserved Ejection Fraction

Summary: heart failure with preserved ejection fraction (hfpef) refers to a group of symptoms and signs of heart failure, normal or near-normal left ventricular systolic function (ef\>50%), and ventricular muscle diastolic dysfunction and a clinical syndrome characterized by decreased compliance and increased stiffness. the pathogenesis of hfpef is related to impaired lipid metabolism and inflammation. epicardial adipose tissue (epicardial adipose tissue, eat) is a kind of visceral adipose tissue. related studies have shown that extracardiac membrane fat is related to inflammation markers, cardiometabolic risk and cardiovascular disease.however, there is still no research investigating the the relationship between epicardial fat thickness and cardiac function in hfpef patients.

heart failure with preserved ejection fraction (hfpef) refers to a group of symptoms and signs of heart failure, normal or near-normal left ventricular systolic function (ef\>50%), and ventricular muscle diastolic dysfunction and a clinical syndrome characterized by decreased compliance and increased stiffness. the pathogenesis of hfpef is related to impaired lipid metabolism and inflammation. epicardial adipose tissue (epicardial adipose tissue, eat) is a kind of visceral adipose tissue, which is composed of adipose tissue deposited between the myocardium and the visceral layer of the pericardium. it is closely adjacent to the coronary arteries and myocardium. related studies have shown that extracardiac membrane fat is related to inflammation markers, cardiometabolic risk and cardiovascular disease.however, there is still no research investigating the the relationship between epicardial fat thickness and cardiac function in hfpef patients. this study intends to observe the relationship between epicardial fat thickness and left and right functions in patients with hfpef, and evaluate whether epicardial fat thickness can be used as an indicator of left and right dysfunction.

Eligibility criteria:
inclusion criteria: * adult aged \>=18years old; * diagnosed with hfpef. diagnostic criteria including: 1. left ventricular ejection fraction ≥50%； 2. with the symptoms and/or signs of heart failure； 3. bnp≥35 pg/ml and/or ntprobnp≥125 pg/ml； 4. at least one additional criterion: relevant structural heart disease(lvh and/or lae) or diastolic dysfunction exclusion criteria: * lvef less than 45% at any time; * severe liver failure; * primary pulmonary hypertension; * age \<18 years old.

Keywords: epicardial adipose tissue cardiac function
extended work schedules, sleep loss and health

Conditions: Sleep

Summary: this study aims to determine whether abnormal bodily rhythms contribute to elevate the risk of diabetes, independently of the amount of sleep loss.


Eligibility criteria:
inclusion criteria: * normal healthy men and women between the ages of 21 years and 39 years (inclusive) with normal weight (i.e., body mass index under 28 kg/m2 in men, 27 kg/m2 in women) * normal findings on clinical examination, normal results on routine laboratory tests, normal ekg, normal glucose tolerance test, negative pregnancy test for women * no personal history of psychiatric or endocrine illness * no personal history of sleep disorder, usual total sleep time of at least 7 hours * only female volunteers with normal ovulatory cycles will be included exclusion criteria: * subjects with irregular life habits (shiftworkers and subjects having traveled across time zones less than one month prior to the beginning of the baseline study) * subjects taking any medication (including hormonal contraceptive therapy), and smokers are excluded * subjects with significant sleep apnea (apnea index above 10) or significant arousal-associated periodic leg movements are excluded

Keywords: shift work diabetes affects of shift work and sleep loss on health
comparison of video and direct laryngoscopy in obese patients during surgery

Conditions: Obesity Difficult Airway Airway Management

Summary: this study aims to evaluate how intubation performed with two different brands of videolaryngoscope and the macintosh laryngoscope during surgeries in obese patients requiring general anesthesia affects the vidiac score, hemodynamic response, and early postoperative complications. complications such as sore throat, hoarseness, nausea, and vomiting will be recorded in the recovery room prior to discharge.

success in airway management is critical for the safety of anesthesia practices. unsuccessful airway management is a leading cause of anesthesia-related morbidity-including airway trauma, dental injury, pulmonary aspiration, unplanned tracheostomy, hypoxic brain injury, and cardiopulmonary arrest-and mortality. unsuccessful airway management accounts for approximately 30-40% of anesthesia-related deaths. in a review of closed insurance claims against anesthesiologists, 17% were related to difficult or impossible intubation without documented preoperative airway assessment. video laryngoscopes are technological tools used to visualize airway structures and facilitate endotracheal intubation, particularly in patients with anticipated difficult airways. obesity is a metabolic disorder characterized by excessive fat accumulation and is associated with both physical and psychological complications. it is an independent risk factor for difficult airway and increases the risk of anesthesia-related complications. obesity is also linked to restrictive lung disease due to increased intra-abdominal pressure and decreased thoracic compliance. the resulting reductions in static and dynamic lung volumes lead to rapid desaturation during apnea or hypoventilation, primarily due to reduced functional residual capacity and expiratory reserve volume. in this prospective observational study, the investigators aim to perform a comparative analysis of vidiac scores, hemodynamic responses (heart rate, systolic and diastolic blood pressure, mean arterial pressure), and early postoperative complications following laryngoscopy performed with storz c-mac videolaryngoscope, scoper videolaryngoscope, and macintosh laryngoscope in obese patients undergoing elective surgery under general anesthesia.

Eligibility criteria:
inclusion criteria: * age between 18 and 65 years * body mass index (bmi) ≥30 kg/m² * asa physical status i or ii * scheduled for elective surgery * requiring endotracheal intubation * provided written informed consent exclusion criteria: * refusal to participate in the study * asa physical status iii, iv, or v * advanced cardiopulmonary disease * cervical spine movement limitation * pregnancy * coagulopathy * emergency surgery indication * known or anticipated difficult airway * severe anatomical deformity of the airway

Keywords: video laryngoscopy obesity vidiac score storz c-mac scoper mac
circadian clocks and eating patterns (cohort)

Conditions: Postpartum Women; Diabetes, Gestational

Summary: for women of reproductive age, the overall postpartum weight retention (weight gain between pregnancies) plays a significant role in long-term obesity. with 20% of women retaining ≥ 5 kg at 12 months postpartum, the risk of developing conditions, such as gestational diabetes mellitus (gdm), metabolic syndrome (ms) and subsequently diabetes and cardiovascular diseases, is substantially increased. in post-gdm mothers (women who had gdm in their recent pregnancy), postpartum weight retention is also an essential predictor of future diabetes. recent studies have identified the impact of circadian rhythms (influencing sleep/wake cycles) and diurnal rhythm of eating (when and how often calories are consumed over a 24h period) on cardio-metabolic disorders. in women, one remarkable feature of the postpartum period is an 'externally imposed' circadian misalignment of both sleep and eating rhythms, because most babies take several weeks to months to establish their daily pattern of activity and feeding, which is particularly relevant for breastfeeding women, as the responsibility is generally on the mother. the overarching goal of this project is to explore the interplay between the diurnal rhythm of eating, circadian and metabolic parameters in humans. the potential postpartum effects of circadian disruption will be unraveled in women who had gdm during their pregnancy and those with an uneventful pregnancy. these women are subject to a circadian misalignment due to their 'externally imposed' changes in sleep/wake cycles and eating times in the postpartum period. with a comprehensive approach combining molecular characterization of in vivo and in vitro circadian clock parameters along with metabolic, endocrine, transcriptomic, and lipidomic studies, the investigators will assess if eating duration and/or circadian misalignment impact on circadian clock parameters of postpartum women in a prospective cohort of 6 months.


Eligibility criteria:
inclusion criteria: * age 18-40 years * breastfeeding mothers at 4-8 week postpartum * with or without gestational diabetes mellitus diagnosed at 24-32 gestational weeks, according to the international association of diabetes and pregnancy study groups (iadpsg) consensus criteria * confident use of a smartphone and able to take regular pictures of food/drinks exclusion criteria: * pre-existing diabetes (prior to pregnancy) * major illness/fever over the 2 weeks (prior to the visits with blood tests) * shift work or work at irregular hours planned after maternity leave * active cancer and/or oncologic treatment over the previous 12 months * coagulation disorder, on regular anticoagulant drug, skin disorder affecting wound healing * enrolled in a clinical trial / intervention study * major known mental illness, unable to give informed consent * inability to follow the study procedures

Keywords: circadian rhythms metabolic syndrome eating duration sleep/wake cycles
the effect of local anaesthesia technique on the recovery after dental treatment in general anaesthesia

Conditions: Postoperative Complications

Summary: use of local anaesthesia during full mouth dental rehabilitation under general anaesthesia is an everyday practice. it enables better control of the post-extraction bleeding and better control of physiological responses. postoperative numbness and lip and cheek biting can be an undesired side effect. with our research, we aim to compare two different types of local anaesthesia in relation to postoperative side effects. we also aim to assess the oral health-related quality of life after treatment in general anaesthesia to enlighten how full mouth rehabilitation affects a child's life.

dental treatment of children under general anaesthesia (ga) is intended for children who, for one reason or another, are unable to participate in the outpatient clinic. when extracting teeth in ga, local anaesthetics (la) are regularly applied to control bleeding, reduce postoperative sensitivity, and to better control vital functions. the side effects of la can be the patient's irritation due to not understanding the postoperative numbness and lip and cheek biting. the aim of our study is to determine if there is a difference between the two types of local anaesthesia (computer-controlled intraosseous anaesthesia and classical local/conductive anaesthesia) in the frequency and extent of the occurrence of side effects postoperatively. the research data would help establish a better dental extraction protocol for children under ga, which would allow for less postoperative complications.

Eligibility criteria:
inclusion criteria: - paediatric patients intended for dental treatment in general anaesthesia exclusion criteria: * patients who can not express feelings adequately, * patients where there will not be any teeth extracted, * patients whose parents do not want to participate in the study
deep brain stimulation for the treatment of obesity

Conditions: Obesity

Summary: the purpose of this clinical study is to investigate the safety and efficacy of deep brain stimulation (dbs) as a treatment option for obesity.

the purpose of this clinical study is to investigate the safety and efficacy of deep brain stimulation (dbs) as a treatment option in the management of severe, treatment refractory, morbid obesity.

Eligibility criteria:
inclusion criteria: * at least 24 months post roux-en-y gastric bypass surgery without evidence of a sustained improvement in bmi after gastric bypass surgery for at least 6 months. * participant is willing to comply with all follow-up evaluations at the specified times * participant is able to provide informed consent * fluent in english exclusion criteria: * medical contraindications for general anesthesia, craniotomy, or dbs surgery * evidence of neurological disorders, e.g., multiple sclerosis, parkinson's disease and ischemic stroke, or severe brain atrophy or the presence of subdural hygromas or subdural hematomas. * severe cardiovascular, pulmonary, renal, liver, hematological disease, severe coagulopathy, acute infectious process

Keywords: obesity dbs
a study of amg 340 in subjects with metastatic castrate-resistant prostate carcinoma

Conditions: Metastatic Castration-resistant Prostate Cancer

Summary: this is a phase 1, open-label study evaluating the safety, clinical pharmacology and clinical activity of amg 340, a psma x cd3 t-cell engaging bispecific antibody, in subjects with metastatic castrate-resistant prostate cancer (mcrpc) who have received 2 or more prior lines of therapy. the study consists of 2 parts, a monotherapy dose escalation (arm a) and a monotherapy dose expansion (arm b). once the maximum tolerated dose (mtd) or recommended phase 2 dose (rp2d) is identified in arm a, arm b will be initiated to further characterize the safety, tolerability and pharmacokinetic (pk) profile of the mtd/rp2d dose of amg 340 monotherapy in subjects with mcrpc.


Eligibility criteria:
inclusion criteria: * pathologically confirmed prostatic adenocarcinoma. * history of metastatic disease. * chemically or surgically castrate. * subject has received at least 2 lines of systemic therapy approved for mcrpc, with disease progression on the most recent systemic therapy as defined in prostate cancer working group 3 (pcwg3) recommendations. * human immunodeficiency virus (hiv), hepatitis b virus (hbv), and/or hepatitis c virus (hcv)-infected subjects that have been cured or who are on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial. * an eastern cooperative oncology group (ecog) performance status of ≤ 2. * subject must have adequate heart, liver, bone marrow and kidney function (e.g. estimated glomerular filtration rate \[egfr\] ≥ 50 ml/min, aspartate aminotransferase \[ast\]/alanine aminotransferase \[alt\] ≤ 3 x upper limit of normal \[uln\], hemoglobin \[hgb\] ≥ 9 g/dl (without blood transfusion within 7 days from screening assessment), platelets ≥ 100,000 / mm\^3 (without platelet transfusion within 7 days from screening assessment), absolute neutrophil count \[anc\] ≥ 1500 / mm\^3). exclusion criteria: * subject has been diagnosed with or treated for another malignancy within the past 2 years whose natural history or treatment may interfere with the safety or efficacy assessment of the investigational regimen. * history of neuroendocrine differentiation in the subject's disease. * subject has a history of central nervous system (cns) involvement by their mcrpc. metastases stemming from bone are allowed. * subject has clinically significant cns pathology. * subject requires chronic immunosuppressive therapy. * subject has a history of major cardiac abnormalities.

Keywords: prostate specific membrane antigen psma prostate cancer metastatic castrate-resistant