Kornimate/medical-research-clean huggingface dataset:
evaluating the unmet needs of older adults to promote functional recovery after a critical illness

Conditions: Critical Illness; Illness, Critical

Summary: this is a prospective longitudinal study that will evaluate the unmet needs of older adults (65 and older) who return home (either directly or after short-term rehab) after an icu hospitalization, evaluate the association of these unmet needs with clinically relevant outcomes, and assess barriers and facilitators to addressing these unmet needs. the proposed research will inform the development and evaluation of a subsequent intervention to improve functional outcomes among older icu survivors, in alignment with the nih's mission to reduce disability.

to identify unmet needs in multiple domains after return home from an icu hospitalization, evaluate whether these unmet needs are associated with disability burden in the subsequent 6 months, and ascertain whether these associations are moderated by initial discharge destination (home or str).

Eligibility criteria:
inclusion criteria: participants * age ≥ 65 years * survived an icu admission of ≥2 days caregivers * age ≥ 18 years * identified as caregiver of lantern participant who is an informal (unpaid) caregiver. exclusion criteria: participants * advance directive of comfort measures only (cmo) or a transition to hospice * planned discharge to a location other than home or short-term rehab * tracheostomy with ventilator dependence * severe acute or prior neurologic injury (such as anoxic brain injury or acute, massive stroke) * advanced dementia * icu admission for monitoring only (e.g., antibiotic desensitization) * primary language other than english. * homelessness * active drug or alcohol use disorder. caregivers * primary language other than english * is a paid caregiver * unwilling to complete a qualitative interview

Keywords: geriatrics older adults
method comparison/user evaluation of the i-sens self-monitoring blood glucose / β-ketone system

Conditions: Diabetes

Summary: the goal of this clinical trial is to assess the accuracy and usability of the blood glucose meter in untrained participants, both with or without diabetes, as well as those with pre-diabetes.

participants will personally date and sign the informed consent before engaging in any study-related activity. participants use a single-use lancing device to lance their finger and perform a blood glucose test with glucose test strips on the meter. trained staff collects more blood samples for ysi and hematocrit measurement (approx. 300-350μl) using a specified lancet within 5 minutes of the first evaluable meter reading. follow the same process to measure ketones using the β-ketone test strip on the same meter. the staff collects more blood samples for imola and hematocrit measurement (approx. 500-550μl). after subjects have completed the testing, they are then asked to complete usability questionnaires.

Eligibility criteria:
inclusion criteria: * males and females, 18 years of age and older * people with type 1 diabetes, type 2 diabetes, pre-diabetes and no diabetes (self- reported) * able to speak, read and understand english (subjects must demonstrate ability to read a sentence from a page of the draft device labeling instructions (user's manual) to qualify for the study) * willing to complete all study procedures * has read, understood, and signed the informed consent form note: the study group consists of naive smbg users and non-naive smbg users. at least 10% of study participants should be naive for smbg, including subjects without diabetes. exclusion criteria: * hemophilia or any other bleeding disorder * works for a medical laboratory, hospital, other clinical setting or a medical device company that involves training on or clinical use of blood glucose meters * physical, visual or neurological impairments as determined by the investigator or designee that would make the subject unable to perform self-testing (reason for exclusion will be clearly documented by investigator or designee directly on the subject disposition form) * a condition, which in the opinion of the investigator or designee, would put the subject or study conduct at risk (reason for exclusion will be clearly documented by investigator or designee on the subject disposition form). note 1: in the event of a physical, visual or neurological impairment that makes it difficult for a subject to complete the questionnaire, the subject's verbal responses will be accepted and should be appropriately documented as such within the subject records form.

Keywords: self-monitoring blood glucose (smbg)
a study to evaluate the efficacy and safety of faricimab in participants with neovascular age-related macular degeneration (lucerne)

Conditions: Wet Macular Degeneration

Summary: this study will evaluate the efficacy, safety, durability, and pharmacokinetics of faricimab administered at intervals as specified in the protocol, compared with aflibercept once every 8 weeks (q8w), in participants with neovascular age-related macular degeneration (namd).


Eligibility criteria:
inclusion criteria: * treatment-naïve choroidal neovascularization (cnv) secondary to age-related macular degeneration (namd) in the study eye * ability to comply with the study protocol, in the investigator's judgment * for women of childbearing potential: agreement to remain abstinent (refrain from heterosexual intercourse) or use acceptable contraceptive measures that result in failure rate \<1% per year during the treatment period and for at least 3 months after the final dose of study treatment * other protocol-specified inclusion criteria may apply exclusion criteria: * uncontrolled blood pressure, defined as systolic blood pressure \>180 millimeters of mercury (mmhg) and/or diastolic blood pressure \>100 mmhg while a patient is at rest on day 1 * pregnancy or breastfeeding, or intention to become pregnant during the study * cnv due to causes other than amd in the study eye * any history of macular pathology unrelated to amd affecting vision or contributing to the presence of intraretinal or subretinal fluid in the study eye * any concurrent intraocular condition in the study eye that, in the opinion of the investigator, could either reduce the potential for visual improvement or require medical or surgical intervention during the study * uncontrolled glaucoma in the study eye * any prior or concomitant treatment for cnv or vitreomacular-interface abnormalities in the study eye * prior ivt administration of faricimab in either eye * history of idiopathic or autoimmune-associated uveitis in either eye * active ocular inflammation or suspected or active ocular or periocular infection in either eye * other protocol-specified exclusion criteria may apply

Keywords: amd namd neovascular age-related macular degeneration choroidal neovascularization secondary to age-related macular degeneration
the probiotic study: using bacteria to calm your mind

Conditions: Anxiety; Abdominal Pain

Summary: the investigators seek to conduct the first open-label trial of probiotics in young children to reduce their anxiety and abdominal pain. likewise, the investigators aim to assess the feasibility and efficacy of this treatment and to elucidate the enteric microbiota in the middle-lower gi tract. self-report measures and a laboratory task will be collected from children, ages 9-13 years of age, and self-report measures from their primary caregivers prior to and following a 30-day probiotic administration. children who score above cutoff in anxiety and/or abdominal pain meet the inclusion criteria for this study. because of limited sample size and the iterative nature of intervention development, criteria for success at the pilot phase are based primarily on clinical rather than statistical criteria. the study personnel will do their best to keep and ensure the privacy and confidentiality of our participants; however, some of the risks of this study may include psychological discomfort, legal risks, and loss of confidentially.


Eligibility criteria:
inclusion criteria: participants need to meet the criteria for functional abdominal pain as specified by the rome iii: scenario #1 criteria for inclusion 1. in the last 2 months, how often did the child have pain or an uncomfortable feeling in the upper abdomen above the belly button? if ≥ 8 (or if the combination of #1 and #2 is ≥8) 2. in the last 2 months, how often did the child have pain or an uncomfortable feeling in the upper abdomen below the belly button? if ≥ 8 (or if the combination of #1 and #2 is ≥8) scenario #2 criteria for inclusion 3. in the last 2 months, when the child hurt or felt uncomfortable above (below) the belly button, how often did your child miss school or stop activities? if #1 and #2 is ≥ 2 (or if the combination of #1 and #2 is ≥2) and #3 is ≥ 25% of the time. they also have to be at or above cutoff (i.e. ts\>= 55) for beck youth inventory (byi) which can be determined by finding the corresponding raw score, gender, and age on appendix a in the byi manual. exclusion criteria: 1. participants with immune disorders will be automatically excluded from this study.
aneurysmal subarachnoid hemorrhage and superior mesenteric artery flow study

Conditions: Intracranial Aneurysm

Summary: the purpose of this research study is to determine if the diameter and flow of the superior mesenteric artery in patients with aneurysmal subarachnoid hemorrhage undergoing hypertensive therapy for cerebral artery vasospasm are effected enough to justify withholding enteral nutrition.

study measurements of the diameter and doppler flow velocity of the superior mesenteric artery (sma) using abdominal ultrasound in order to evaluate the potential additional risk of non-occlusive mesenteric ischemia (nomi) and non occlusive bowel necrosis (nobn) in patients undergoing hypertensive therapy for cerebral vasospasm in aneurysmal subarachnoid hemorrhage (asah), to justify the withholding of enteral nutrition.

Eligibility criteria:
inclusion criteria: * patient diagnosed with asah exclusion criteria: * hemodynamic instability * already receiving vasopressor therapy * non-aneurysmal sah * intracranial hemorrhage of other cause * not anticipated to receive hypertensive therapy with vasoactive medications for cerebral vasospasm from sah or suspected asah * unable to visualize sma using ultrasound * pregnancy

Keywords: asah
biomarkers for diagnosis of lung cancer

Conditions: Lung Cancer; Lung Neoplasm

Summary: the study goal is to collect blood samples from individuals at risk for lung cancer in order to identify protein markers for diagnosis of lung cancer in the chinese population.


Eligibility criteria:
inclusion criteria: * adults ≥ 18 years of age * patients referred to pulmonologists, oncologists, or thoracic surgeons for diagnosis of suspicious pulmonary nodules as either lung cancer or benign and undergoing bronchoscopic biopsy * patients will be enrolled if the result of the bronchoscopic biopsy is a diagnosis of nsclc or benign pulmonary nodule * cases: patients with untreated non-small cell lung cancer, i.e. primary lung adenocarcinoma or squamous cell carcinoma of early * computed tomography or x-ray is available and shows a suspicious pulmonary nodule * a biopsy or surgical resection to clarify the nature of the lung nodule is available (nsclc or benign, including histological diagnosis) in both groups * controls: patients must be available for a 6 month follow-up to confirm benign diagnosis * a serum and plasma sample was collected prior to any treatment of the lung nodule beyond biopsy * no other cancer diagnosis in the last 5 years excluding non-melanoma skin cancer * patients must be fully informed of the investigational nature of the procedure and sign an informed consent. exclusion criteria: * prior treatment for lung cancer by chemotherapy or surgery (excluding biopsy) * patients with benign nodules who are not able or willing to have a 6-month follow-up visit to confirm benign diagnosis * diagnosis or treatment of other cancer in the last 5 years excluding non-melanoma skin cancer. in the judgment of the clinical investigator, patients who are likely to be non compliant or uncooperative during the study.

Keywords: primary lung adenocarcinoma stages i, ii, iiia, iiib squamous cell carcinoma stages i, ii, iiia, iiib benign non-calcified pulmonary nodules early detection
investigation of the effectiveness of acupuncture in patients diagnosed with interstitial cystitis

Conditions: Interstitial Cystitis; Bladder Pain Syndrome

Summary: interstitial cystitis/bladder pain syndrome is a non-bacterial chronic inflammatory disease of the bladder characterized by lower urinary tract symptoms such as dysuria, irritating urgency, and nocturia, as well as pelvic pain associated with bladder filling. the international continence society (ics) defines bladder pain syndrome as "a complaint of suprapubic pain due to bladder filling accompanied by urinary system symptoms such as increased daytime and nighttime urinary frequency as a result of the exclusion of proven urinary infection or other obvious pathologies." acupuncture is an important treatment method of traditional chinese medicine that has been used for more than 2500 years and is performed by placing needles at specific points on the skin. in the literature, clinical studies have been conducted to evaluate the effectiveness of acupuncture in interstitial cystitis and its effectiveness in relieving symptoms has been demonstrated. in the light of these data, our aim in our multi-centered study is to investigate the effectiveness of acupuncture in relieving symptoms and improving the quality of life in patients diagnosed with interstitial cystitis. in our study, patients who applied to the urology clinic between 01.02.2024 and 01.07.2024 with pelvic pain or discomfort lasting more than 6 months and lower urinary tract symptoms such as frequent urination, dysuria and nocturia will be examined and evaluated with suspicion of interstitial cystitis diagnosis.


Eligibility criteria:
inclusion criteria: * who diagnosed ic/bps * between 30-65 years old * female exclusion criteria: * patients who do not meet the ic/bps diagnostic criteria, * who have previously received acupuncture treatment, * who have localized skin infections involving the acupuncture areas, * who have bleeding diathesis and who use anticoagulant drugs, * who cannot comply with the treatment and follow-up schedule will not be included in the study.

Keywords: acupuncture interstitial cystitis bladder pain syndrome
autologous hematopoietic stem cell transplantation for refractory autoimmune diseases

Conditions: Autoimmune Diseases

Summary: while glucocorticoids and immunosuppressants ameliorate manifestations of autoimmune diseases in many patients, current therapies are insufficient to control the disease in a subset of patients, and their clinical prognosis remains poor due to the development of vital organ failure, cumulative drug toxicity and to the increased risk of cardiovascular disease and malignancy. immunoablative chemotherapy followed by autologous hematopoietic stem cell transplantation (asct) has recently emerged as a promising experimental therapy for severely affected patients, providing them the potential to achieve treatment-free, long-term remission. the rationale for applying asct to autoimmune diseases has been the hope that immunoablation could eliminate inflammation-driving pathogenic cells from the immune system, and that regeneration of the patients' immune system from hematopoietic precursors could re-establish immunological tolerance.


Eligibility criteria:
inclusion criteria: * autoimmune disease * active disease with inadequate response to standard protocols (glucocorticoids and at least two different regimens of immunosuppressive drugs, such as intravenous cyclophosphamide 800-1000mg/application) * provision of informed consent by subject exclusion criteria: * active or chronic infections * uncontrolled arrhythmia or congestive heart failure (ejection fraction below 50% determined by echocardiogram) * lung fibrosis (transfer factor for carbon monoxide \[tlco\] \<45%) * renal insufficiency (glomerular filtration rate below 40 ml/min) * pulmonary arterial hypertension (\>40mmhg) * history of malignancy * women who are pregnant or breastfeeding * use non-reliable methods of contraception

Keywords: asct tolerance induction sle transplantation autoimmune diseases
effect of partial rib resection on the control of post-thoracotomy pain

Conditions: Pain, Postoperative; Iatrogenic Injury; Post-thoracotomy Pain Syndrome

Summary: the aim of this study is to evaluate the effect of partial rib resection in reducing acute post-thoracotomy pain

it is known that severe post thoracotomy pain can be reduced by half with some strategies to prevent pain development. it was thought that partial rib resection would reduce intercostal tension and prevent an uncontrolled fracture. thus, it is argued that post thoracotomy pain can be reduced. partial rib resection is applied in clinical practice in selected patient groups. however, we could not find a clinical study on this subject in the english literature. the aim of this study is to determine whether partial rib resection has an effect on the control of thoracotomy pain. before the thoracotomy incision, simple randomization will be performed by flipping a coin. routine thoracotomy incision will be performed in the control group. in the intervention group, approximately 1 cm segment of the 6th rib will be excised with a rib scissors before the thorax retractor was placed. pericostal suture technique will be used in both groups at thoracotomy closure. demographic information of the cases, preoperative respiratory function parameters, body mass index, visual analogue scale scores, complications and analgesic doses will be recorded in the case report form regularly.

Eligibility criteria:
inclusion criteria: * participants who underwent thoracotomy in our clinic in 2019-2020 * participants signing an informed consent form exclusion criteria: * thoracic wall tumor * invasion of the thoracic wall by extrathoracic malignancy * pleural pathology * history of previous rib fracture * history of previous thoracotomy * history of thoracic radiotherapy * emergency surgery * simultaneous incisions other than thoracotomy

Keywords: post thoracotomy pain iatrogenic rib fracture thoracotomy partial rib resection
bariederm cream in chronic contact dermatitis

Conditions: Contact Dermatitis

Summary: we intend to evaluate the efficiency and tolerability of a barrier cream (bariederm) in protecting hands of individuals with hand dermatitis, either due to allergy or irritation. we believe that the use of the cream would benefit with the skin.

the aim of the study is the evaluation of the effectiveness, tolerance and cosmetic acceptability of bariéderm cream among patients presenting with chronic allergic or irritant contact dermatitis of the hands. we shall enrol adults presenting with contact dermatitis excluding flare-ups of the hands: whether allergic or irritant, able to understand the protocol and agrees to sign the information and informed consent form. bariéderm cream will be applied minimum twice daily over 21 days. response will be evaluated by self and physician filled questionnaires. effectiveness, tolerance and cosmetic acceptability will be evaluated by a scale of 1-10, 1 meaning "not at all" and 10 meaning "very much". statistics will be performed by spss software with suitable statistical tests. in case of an adverse event caused by the product, patch-test with ingredients of bariéderm cream will be performed.

Eligibility criteria:
inclusion criteria: * patients with dermatitis of the hands exclusion criteria: * pregnant ladies, * known allergy to ingredients -
calm- 2 - controlling and lowering blood pressure with the mobiushd™

Conditions: Hypertension; Resistant Hypertension

Summary: the objective of this study is to evaluate the safety and effectiveness of the mobiushd system in a prospective, randomized, double-blind, sham-controlled multi-center pivotal study.

the objective of this study is to evaluate the safety and effectiveness of the mobiushd system in a prospective, randomized, double-blind, sham-controlled multi-center pivotal study. patients with resistant hypertension who remain uncontrolled despite pharmacologic treatment with maximum tolerated, guideline-directed anti-hypertensive pharmacologic therapy will be evaluated.

Eligibility criteria:
inclusion criteria: * mean 24 hour ambulatory systolic blood pressure ≥145 mmhg and ≤200 mmhg and stable for at least 8 weeks on a maximally tolerated guideline directed, (jnc8) or their equivalent when those listed are not available dosing regimen consisting of up to 5 antihypertensive medications, with a minimum required dosing regimen of an "a+c+d" antihypertensive medication regimen, where "a" is an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker, "c" is a calcium channel blocker, and "d" is a diuretic. exclusion criteria: * inadequacy of the carotid anatomy for treatment with the mobiushd based on carotid angiography.

Keywords: hypertension resistant hypertension baroreceptor bat
online cognitive behavioral intervention program for hong kong people with depression

Conditions: Depression

Summary: the purpose of this study is to develop a culturally and linguistically appropriate online cognitive behavioral intervention program-- with therapist guidance -- for hong kong chinese adults suffering from major depressive disorder with mild to moderate depressive symptoms, and examine the effectiveness of this program in reducing their depressive symptoms and improving their mental health. the 3- and 6-month maintenance effect after 3 months and 6 months will also be tested.

previous studies have demonstrated that online cognitive behavioral therapy can significantly reduce depressive symptoms and improve mental health for people with depression. this project will develop an online cognitive behavioral intervention program (including both an online platform and a smartphone application) for hong kong people with depression. blended mode will be delivered service, which include 8-week online program, 2 face-to-face sessions and 2 telephone follow-ups by a clinical psychologist. the program will be evaluated in its effectiveness in reducing depressive and anxiety symptoms, psychological distress, negative thoughts and negative emotions and increasing positive thoughts and positive emotions.

Eligibility criteria:
inclusion criteria: * hong kong resident * has mild to moderate depressive symptoms * no suicidal risk in the past 3 months * receive no face-to-face counselling since program commencement * has access to a computer/smartphone with internet access * has a valid email address exclusion criteria: * has severe or no depressive symptoms * has suicidal risk in the past 3 months * currently receiving other psychological treatment * suffer from severe psychiatric conditions, such as bipolar disorder or schizophrenia * has no computer or smartphone with internet access * has no valid email address

Keywords: online cognitive behavioral intervention hong kong chinese depression