Kornimate/medical-research-clean huggingface dataset:
effects of a pre-workout on performance, perceptual responses, energy feelings and muscular properties, after a training microcycle in adults.

Conditions: Protein Deficiency; Training Group, Sensitivity; Fatigue; Muscular Atrophy; Psychological

Summary: the investigation will be conducted as a double blinded, randomized, crossover within-participant comparison design with two 1-week intervention periods separated by 2-weeks for wash out, recovery, period.

following inclusion, familiarization and baseline assessments, the participants will be randomly allocated to receive either a multi-ingredient, pre-workout supplement (prew) or maltodextrin (cho). thereafter, the participants will take a 5-day microcycle, involving three resistance training sessions (monday, wednesday and friday) intercalated with two endurance training sessions (tuesday and thursday). after the first interventional microcycle, and the 2-week washout period, the participants will switch to the other nutritional condition for continuation with the second 5-day identical microcycle. assessments of muscle contractile properties via tensiomyography on vastus medialis, biceps femoris long head and anterior deltoids will be taken before and after each resistance training session. measurements of strength (isometric mid thigh pull) upper and lower body muscular power (medicine ball throw and vertical jump) will be performed immediately after each resistance training workout. the supplements will be ingested 15 min before each training session, just before completing an energy feeling questionnaire. in addition, the perceptual response to training will be assessed during and 20 min after the completion of all workouts. the contribution of carbohydrate and fat metabolism will be estimated using a gas analyzer via the calculation of respiratory exchange ratio the (rer) during each endurance training session.

Eligibility criteria:
inclusion criteria: * healthy (no current injuries). * between 45 and 70 years old. * active. exclusion criteria: * injuries. * never trained before. * under 45 or over 70 years old.

Keywords: fatigue supplement pre-workout muscle recovery training strength endurance perceptual response
real life of aflibercept in france in patients refractory to ranibizumab: observational study in wet amd

Conditions: Wet Macular Degeneration

Summary: the aim of the titan study is to describe the clinical practices of a cohort of patients with wamd refractory to ranibizumab (persistence of intra-retinal and/or subretinal fluid) who switch to aflibercept after less than 12 months of ranibizumab treatment. the study will be conducted in real-life conditions and will allow describing conditions of use of aflibercept in patients refractory to ranibizumab

the study is both retrsopective and prospective to collect local real life data on patients under routine treatment. the observation periods starts on january 2014. patients who initiated a treatment by aflibercept between the 1st of january 2014 and the 31 december 2015 will be enrolled.

Eligibility criteria:
inclusion criteria: * man or woman \> 18 years old * patient with wamd previously treated with ranibizumab (for less than 12 months before initiation of aflibercept) * refractory to ranibizumab (defined by persistent fluid despite a treatment conducted according to the has french recommendations with at least 3 loading doses injections) * patient who switched to aflibercept (eylea) between 1st of january 2014 and 30th june 2015 * written informed consent given exclusion criteria: * patient who do not meet the local indication criteria for aflibercept treatment. contraindications listed in the local smpc (summary of product characteristics) have to be considered * recurrent patients with wamd previously treated with ranibizumab and switched to aflibercept because of a high recurrence rate (recurrent patients described by yonegawa et al.in ajo (american journal of ophthalmology )2013= exudation suppressed but high rate of injections) * patient who have been previously treated by any macular laser visudyne/pd (photodynamic therapy) * patient with a visual acuity (va) \<1/10 * patient with fibrosis involving macula * patient with atrophic amd * patient with any other retinal disease as myopia, diabetic retinopathy, diabetic macular oedema,chorioretinal anastomosis (cra),, angioid streaks * patients taking part in an interventional study at the time of enrolment

Keywords: wet-amd refractory patients to ranibizumab real life switch aflibercept
synthetic bone graft substitute vs. autologous spongiosa in revision anterior cruciate ligament reconstruction

Conditions: Anterior Cruciate Ligament Injury

Summary: the overall objective is the histological and radiological assessment of bony consolidation of the tibial/femoral tunnel using either bone graft substitute (actifuse) or autologous spongiosa in patients undergoing revision anterior cruciate ligament reconstruction. clinical correlation with the histological and radiological results using the sf36 questionnaire.

\* study design: monocentric, prospective, randomised study. patients who need revision anterior cruciate ligament reconstruction and show a tunnel enlargement of \>10mm will have a first operation filling the tibial/femoral tunnel either with bone graft substitute (actifuse) or autologous spongiosa. 5 - 6 months after this first operation a ct will be performed to assess the bony consolidation of the former tibial/femoral tunnel. an mri will be performed to assess vitality of the bone substitute. an osseous biopsy will be taken from the tibial/femoral tunnel at the revision anterior cruciate ligament reconstruction approximately 6 months after bone grafting. clinical evaluation will be performed 6 weeks, 3 months and 6 months postoperative. at 6 months postoperative additional radiological evaluation and clinical assessment using the sf36 questionnaire will be performed. * treatment: either autologous spongiosa or actifuse (mis applicator) will be administered by the investigator as a bone graft substitute for tunnel enlargement in patients undergoing revision anterior cruciate ligament reconstruction. * duration of participation: the participation of each subject will be approximately 12 months. each subject will undergo revision anterior cruciate ligament reconstruction approximately 6 months after bone grafting. a biopsy will be taken at this operation. a clinical and radiological follow up is planned for further 6 months. \* subjects: male and female patients ≥ 18 years. approximately 40 patients who undergo revision anterior cruciate ligament reconstruction will be included in the study. inclusion criteria: patients in need of revision anterior cruciate ligament reconstruction exclusion criteria: infection, wound healing complications

Eligibility criteria:
inclusion criteria: * patients in need of revision anterior cruciate ligament reconstruction exclusion criteria: * infection, wound healing complications

Keywords: acl revision surgery tunnel enlargement bone substitute material bone graft
endoscopic management of esophageal wall defects

Conditions: Esophageal Fistula; Esophageal Perforation

Summary: the study aim at comparing outcomes from the implementation of various endoscopic closure techniques including stenting and suturing on the healing and resolution of esophageal wall defects.

esophageal wall defects are a rare but potentially life-threatening subset of luminal pathology which usually require timely intervention in order to reduce the known associated high morbidity and mortality. these defects can be due to surgical and endoscopic procedures, such as post-operative leaks and fistulas and perforations complicating endoscopic dilation. in addition, defects can occur spontaneously due to boerhaave's syndrome or following chemoradiation treatments of esophageal or other chest malignancies. surgical management was historically the mainstay of therapy for these defects with conservative management remaining an alternative in poor surgical candidates. over the last several years however, interventional endoscopy has played an increasing role in treatment of esophageal wall defects, with endoscopic stenting quickly becoming a viable alternative. temporary stents including the fully covered self-expandable metal stents (fc-sems), partially covered self-expandable metal stents (p-sems) and self-expandable plastic stents (seps) have all been successfully used and have become increasingly regarded as the new standard of care. indiana university is a tertiary referral center is a destination for complex thoracic surgery, oncology and esophageal disease referrals. the innovative luminal endoscopy team started employing a several modalities including flexible endoscopic suturing and stenting to close esophageal defects. to our knowledge, there is a dearth of data on outcomes associated with multi-modality esophageal defect closure techniques and little to no data comparing this approach to the current standard of care of stenting alone or surgery.

Eligibility criteria:
inclusion criteria: * any patient with spontaneous or iatrogenic esophageal wall defect exclusion criteria: * none
microbiota restoration therapy in hiv with repeated low-dose interventions

Conditions: HIV Infection

Summary: altered interplay between gut mucosa and dysbiotic bacteria during hiv infection seems to contribute to chronic immune dysfunction. manipulation of the intestinal microbiota with nutritional interventions exert limited immunologic effects, but a deep understanding of how these interventions could ameliorate gut dysbiosis and influence health among hiv-infected individuals remain unexplored. in this phase i clinical trial, 30 hiv-infected subjects on effective art with evidence of persistent immune dysfunction, indicated by a cd4/cd8 ratio\<1 will be included and randomized to either repeated low-dose oral fecal microbiota transplantation or placebo during 8 weeks. the primary outcome will be safety. secondary outcomes will include changes in cd4+ t cell counts, cd8+ t cell counts, cd4/cd8 ratio, inflammatory markers, t cell activation and markers of enterocyte barrier function through week 48. engraftment on host microbiota will be examined using illumina sequencing of the v3-v4 16s rna, and changes in bacterial metabolism and in the plasma metabolite fingerprint will be studied by combination of untargeted mass spectrometry and two different and complementary separation techniques in bacterial and plasma samples.


Eligibility criteria:
inclusion criteria: * on stable antiretroviral therapy with plasma hiv rna \<20 copies/ml during at least 48 weeks. * cd4/cd8 ratio \<1 exclusion criteria: * pregnancy * gastrointestinal diseases, including cirrhosis * active infections, including hcv * ebv and/or cmv negative patients (donors are not screened for ebv/cmv). * planned used of chemotherapy or antibiotics * allergy to sodium chloride or glycerol (the former components are capsule ingredients generally recognized as safe (gras) * current or planned use of antimicrobial agents (including prophylactic treatments against p. jiroveci) other than art. * neutropenia \<500 cells/ul or cd4 counts \<350 cells/ul * patients unable to give informed consent * patients unable to comply with the protocol requirements * predicted death within time period of follow-up * any other condition for which the treating physician thinks the treatment may pose a health risk * dysphagia: oropharyngeal, esophageal, functional, neuromuscular (e.g. stroke, multiple sclerosis, als) * history of aspiration * history of gastroparesis

Keywords: hiv microbiota inflammation fecal microbiota restoration
study of the conformis iduo(r) g2

Conditions: Bicompartmental Osteoarthritis

Summary: to evaluate the conformis iduo g2 implant

this is a prospective, multicenter study. the investigators will be evaluating the conformis iduo g2 implant.

Eligibility criteria:
inclusion criteria: 1. clinical condition included in the approved indications for use for the iduo® g2 2. bicompartmental osteoarthritis defined as medial and patellofemoral osteoarthritis, or lateral and patellofemoral arthritis as confirmed by the investigator's assessment of disease status at screening visit. disease status is assessed by clinical and radiographic assessment. in addition, ct arthrogram assessment may be utilized for diagnosis. 3. willingness to participate in the clinical study, to give informed consent and to attend all follow-up visits 4. \> 18 years of age exclusion criteria: 1. bmi \> 40 2. active malignancy (defined as a history of any invasive malignancy - except non-melanoma skin cancer), unless patient has been treated with curative intent and there have been no clinical signs or symptoms of the malignancy for at least 5 years 3. poorly controlled diabetes 4. neuromuscular conditions which prevent patient from participating in study activities 5. active local or systemic infection 6. immunocompromised 7. fibromyalgia or other general body pain related condition 8. rheumatoid arthritis or other forms of inflammatory joint disease 9. loss of bone or musculature, osteonecrosis, neuromuscular or vascular compromise in the area of the joint to be operated to an extent that the procedure is unjustified 10. diagnosed or receiving treatment for osteoporosis 11. other physical disability affecting the hips, spine, or contralateral knee 12. severe instability due to advanced loss of osteochondral structure 13. prior arthroplasty of the affected knee 14. compromised acl, pcl or collateral ligament 15. severe fixed valgus or varus deformity of \>15º 16. extensor lag \> 15 º 17. fixed flexion contracture ≥ 10 º 18. prior history of failed implant surgery of the joint to be treated, including high tibial osteotomy (hto) 19. unwilling or unable to comply with study requirements 20. participation in another clinical study which would confound results 21. if during intra-op, it is noted that the patient has tri-compartmental disease, then the patient is considered a screen fail

Keywords: knee osteoarthritis bicompartmental arthroplasty joint diseases
the use of transcranial focused ultrasound for the treatment of depression and anxiety

Conditions: Depression; Anxiety

Summary: the purpose of this open label study is to evaluate longer term tolerability and early efficacy of transcranial ultrasound in the treatment of patients with refractory depression and anxiety.

the present study is designed as an open label study of patients with refractory depression and anxiety to evaluate longer term tolerability and early efficacy of transcranial ultrasound treatment. baseline and outcome measures in this study utilize validated tests that are appropriate for repeated measures which are not affected by practice effects. for patients with refractory depression, the target will be the subgenual cingulate (brodmann's area 25) through a trans temporal scalp window. for patients with anxiety, the target will be the amygdala. targeting will include reference to scalp fiducials based on the obtained mri and doppler waveform confirmation will be obtained because of the ability of tcd to record doppler signal from the posterior cerebral artery that runs medial to the mesial temporal lobe. on the day of the ultrasound appointment, patients will undergo ten to thirty minutes of transcranial ultrasound treatment. the sonification device will be aimed at the subgenual cingulate or amygdala, depending on the predetermined condition. targeting will include reference to scalp fiducials based on the obtained mri; confirmation of target accuracy will either be obtained by doppler waveform confirmation or optical tracking technology which co-registers patient neuroimaging with real space. patients will undergo 8 total sessions of focused ultrasound. patients will be evaluated at baseline and upon final ultrasound treatment using the same measures obtained upon entry. safety and any adverse events will be monitored closely.

Eligibility criteria:
inclusion criteria for depression: * diagnosis of major depressive disorder * score greater than 13 on the beck depression inventory * failure to remit with 3 antidepressants * at least 18 years of age inclusion criteria for anxiety: * diagnosis of generalized or acute anxiety disorder * score greater than 15 on the beck anxiety inventory * failure to remit with 3 anxiolytics * at least 18 years of age exclusion criteria for depression \& anxiety: * cognitive decline clearly related to an acute illness * subjects unable to give informed consent * subjects who would not be able to lay down without excessive movement in a calm environment sufficiently long enough to be able to achieve sleep * recent surgery or dental work within 3 months of the scheduled procedure. * pregnancy, women who may become pregnant or are breastfeeding * advanced terminal illness * any active cancer or chemotherapy * any other neoplastic illness or illness characterized by neovascularity * macular degeneration * subjects with scalp rash or open wounds on the scalp (for example from treatment of squamous cell cancer) * advanced kidney, pulmonary, cardiac or liver failure
effects of pericapsular nerve group block applied in patients undergoing hip fracture surgery.

Conditions: Hip Fractures; Pain, Postoperative

Summary: in this study, it was aimed to compare the multimodal analgesia application or the pericapsular nerve group (peng) block methods in patients undergoing hip surgery. the effectiveness and benefit rate of the peng block in postoperative pain will be evaluated. postoperative pain, need for additional analgesia, range of motion of the hip joint, mobilization time, length of hospital time and adverse events in patients undergoing hip fracture surgery with and without peng block will be investigated.

this prospective randomised controlled study included a total of 70 patients aged 30-85 years who underwent hip fracture surgery under spinal anaesthesia. patients were randomly divided into two groups using the sealed envelope method, group i: those who received peng block (n:35) and group ii:those who did not receive peng block (control group) (n: 35). all patients will undergo hip fracture surgery by the same surgical team. each patient will be informed about the procedure to be performed during anesthesia and surgery, and signed informed consent will be obtained before the procedure.patients in group i who will undergo the peng block method; before surgery, after spinal anesthesia, peng block is performed under sterile conditions under ultrasonography guidance. with the patient supine, a 2-5 mhz, low-frequency, curvilinear probe is placed in the transverse plane medial to the anterior inferior iliac spine (aiis), with the medial end of the probe rotated approximately 45° counterclockwise to align with the superior pubic ramus. with the peng block, an 80 mm block needle is placed in the fascial plane between the psoas tendon and the pubic ramus and 20 ml of 0.5% bupivacaine is administered. as for the patients in group ii (control group); it is a routine practice at the end of surgery; 10 ml 0.5% bupivacaine + 10 ml 2% lidocaine is infiltrated into the surgical area by the surgical team. for routine postoperative multimodal analgesia, intravenous pca (patient controlled analgesia) was administered to patients in both groups with tramadol 50 mg at a basal rate of 10 mg / hour after loading (20 mg bolus dose + 30 minutes lock time) and paracetamol 10 mg / kg iv. (given every 8 hours)

Eligibility criteria:
inclusion criteria: * patients who will undergo hip fracture surgery women and men aged 30-85 exclusion criteria: * patients under 30 years old, over 85 years old * american society of anesthesiology (asa) iv, * those with cognitive impairment (alzheimer, dementia, delirium, etc.) * those with application site infection * those who are allergic to local anesthetic substances * patients are non-consenting patients.

Keywords: peng block anesthesia
combined effects of vestibular rehabilitation with dual task training in vestibular disorders

Conditions: Vestibular Function Disorder

Summary: patients with vestibular disorders often experience cognitive-motor interference which can adversely affect their motor performance, significantly impair daily functioning, increase instability, reducing quality of life and increasing the risk of falls. vestibular rehabilitation is a well-established therapeutic approach for managing vestibular disorders in reducing symptoms and improving balance and mobility. similarly, dual task training improves cognitive-motor integration by enhancing both cognitive and motor functions and has shown promising results in other populations. this study is aimed to determine the combined effects of both interventions as it might provide a more comprehensive and effective treatment, ultimately improving patient outcomes and quality of life.

in previous studies, vestibular rehabilitation is well-documented in enhancing balance, gait, reducing dizziness and improving quality of life through specific exercises aimed at improving vestibular function. similarly, dual task training has shown promise in improving functional mobility and cognitive processing. however, no randomized control trial to date has systematically investigated the potential synergistic effects of these two interventions when applied together which leaves a critical gap in understanding whether the integration of dual task training into vestibular rehabilitation could yield superior outcomes for patients suffering from vestibular disorders. this research could provide valuable insights and potentially enhance therapeutic strategies for this population.

Eligibility criteria:
inclusion criteria: * patients complaining of dizziness for longer than 3 months * patients with history of at least 1 bout of dizziness per month * patients with history of at least 1 fall in previous 6 months * diagnosed patients as having vestibular disorder by an otolaryngologist * mini mental state examination (mmse) score greater than 24 exclusion criteria: * patients with meniere disease and bilateral vestibular disorders * patients with central nervous system disorders, and psychiatric disorders * patients having visual impairment that could not be treated with lenses or glasses * dizziness not resulting from vestibular disorder or use of medication for dizziness * movement limitation due to orthopedic problems * those who were unable to sign informed consent form

Keywords: vestibular disorders vestibular rehabilitation dual task exercises quality of life gait