Kornimate/medical-research-clean huggingface dataset:
ultrasound-guided lavage of calcific deposits of the rotator cuff

Conditions: Rotator Cuff Tendinitis; Ultrasonography, Interventional; Ultrasonography, Doppler, Color

Summary: the primary goal of the study is to assess ultrasonographic power doppler signals after ultrasound-guided puncture and lavage of rotator cuff calcific tendinitis of the shoulder. secondary outcomes are sonographic features like the course of residual calcific material and the course of tendon healing als well as the clinical symptoms of the patient.

in our study we investigate the intensity of the power doppler signal after ultrasound-guided puncture and lavage (ugpl) of the rotator cuff calcific tendinitis. we assume that ugpl will lead to intratendinous neovascularisation and that the amount of retrieved calcific material is associated with the pdus signal. the measurement of the signal will be performed in pre determined time slot for 12 months. additional we study the correlation between the pdus signal and the clinical symptoms of the patient and the healing process.

Eligibility criteria:
inclusion criteria: * patient aged 18 years and older * pain in the deltoid region worsening with activities above shoulder level and/or at night with a calcific deposit * ultrasound evaluation of the calcific deposit with type i or ii characteristics, a solitary conformation, a minimum size of 1.0 x 0.5 x 0.4cm (length x width x depth) and without clear signs of resorption (pdus grade 0 - i°, see study procedure). * in case of multiple calcific deposits, it has to be warranted that the other deposits are smaller than the minimum size of 1.0 x 0.5 x 0.4cm and with no signs of pdus signals. * qualification for more intensive treatment on account of no clinical improvement after a minimum of 3 months with conservative treatment (physical therapy and oral anti-inflammatory drugs). * able to understand the content of the patient information / consent form in german and give consent to take part in the project exclusion criteria: * previous ugpl or surgery of the affected shoulder * treatment with subacromial injection (sai) or eswt in the three months before inclusion * other causes of shoulder complaints (e.g. rotator cuff tear, frozen shoulder, inflammatory arthritis, bursitis, ...) * intervention failure (no retrieval of calcific material, leakage of the injected saline, disruption of the calcific rim or distribution of calcific material) * patients with a language barrier hindering questionnaire completion * pregnancy

Keywords: calcific deposit ultrasound-guided puncture and lavage power doppler ultrasound
left ventricular lead position in cardiac resynchronization therapy

Conditions: Heart Failure

Summary: left ventricular (lv) lead position has crucial impact on cardiac resynchronization therapy (crt) success. this study will compare fluoroscopy and myocardial deformation imaging for optimal definition of lv lead position.

in a 16 segment model circumferential strain will be used to determine the segment with latest peak systolic circumferential strain prior to crt, considered as the optimal lv lead target. lv lead will be defined by (1) fluoroscopy, (2) the maximal temporal difference of peak circumferential strain before-to-on crt and (3) the earliest peak systolic circumferential strain during lv pacing. for all 3 modalities optimal lv lead position is defined as concordance or immediate neighbouring of the segment with defined lv lead position to the determined optimal target segment. at follow-up echocardiography will be performed to determine improvement in lv function and remodeling.

Eligibility criteria:
inclusion criteria: * see above * males and females * ages 18 to 80 years exclusion criteria: * patients who already have had a pacemaker device * patients with poor echocardiographic window * patients who are not able to understand the study and to give informed written consent

Keywords: cardiac resynchronization therapy echocardiography heart failure left ventricular function pacing myocardial deformation imaging optimal definition of left ventricular lead position in cardiac resynchronization therapy
the effect of fluconazole on pharmacokinetics of fesoterodine in healthy subjects

Conditions: Overactive Bladder With Symptoms of Frequency, Urgency, and Urge Urinary Incontinence

Summary: this study is designed to estimate the effect of fluconazole (200 mg bid for 2 days), a moderate cyp3a4 inhibitor on the pharmacokinetics of a single 8 mg oral dose of fesoterodine in healthy adult subjects.


Eligibility criteria:
inclusion criteria: * healthy subjects between the ages of 18 and 55 years exclusion criteria: * not healthy subjects. subjects with acute or chronic medical or psychiatric condition or laboratory abnormality

Keywords: the effect of fluconazole on pharmacokinetics of fesoterodine in healthy subjects
the effect of tympanostomy tube insertion on sleep in children with chronic otitis media with effusion

Conditions: Chronic Otitis Media With Effusion; Sleep Disturbances

Summary: the purpose of this study is to investigate the prevalence of sleep disturbances in children with chronic otitis media with effusion (come) and the effect of tympanostomy tube insertion (tti) on sleep disturbances.

comparison of sleep disturbances will be between infants with chronic otitis media with effusion (come) who will be referred for tympanostomy tube insertion (tti) (study group) and healthy infants that were recruited from the community well-baby clinics (control group). to evaluate sleep patterns, parents of the study group will complete two validated sleep questionnaires assessing the infant's typical sleep patterns based on parental reports. a week before tti and 1 week to 1 month after the surgery, sleep will be evaluate by actigraph for a week long.

Eligibility criteria:
inclusion criteria: * age: 6-36 months * referred for tympanostomy tube insertion as a treatment for come. exclusion criteria: * snoring and sleep disordered breathing (sdb) * chronic medical condition * referred for tti and adenoidectomy/tonsillectomy
evaluation of the ulthera™ system for obtaining lift and tightening of the cheek tissue

Conditions: Mild to Moderate Skin Laxity on Cheek; Mild to Moderate Skin Laxity on Upper Neck; Mild to Moderate Subcutaneous Fat on Cheek; Mild to Moderate Subcutaneous Fat on Upper Neck

Summary: the clinical trial evaluates the clinical outcomes associated with the non-invasive treatment to obtain lift and tightening of the cheek tissue and improve jawline definition and submental skin laxity utilizing the ulthera™ system which delivers ultrasound energy in a focused manner below the surface of the skin

the primary objective of this study is to demonstrate the effectiveness of the ulthera™ system for the non-invasive dermatological treatment to obtain lift and tighten the cheek tissue. the secondary objective of this study is to demonstrate the effectiveness of the ulthera™ system for the non-invasive dermatological treatment for improvement in jawline definition and submental skin laxity at 3 and 6 months compared to baseline based on the consensus of the three masked reviewers.

Eligibility criteria:
inclusion criteria: * male or female, aged 35 to 60 years * subject in good health * desire lift and tightening of cheek tissue, improvement of jawline definition or submental skin laxity exclusion criteria: * pregnant or lactating * has an active systemic or local skin disease that may alter wound healing * severe solar elastosis * excessive subcutaneous fat on the cheeks * excessive skin laxity on the lower face and neck * has significant scarring in areas to be treated * has significant open facial wounds or lesions * has severe or cystic acne on the face
effect of breathing techniques on migraine attacks and severity

Conditions: Migraine Headaches; Breathing Techniques

Summary: background: migraine is a very common neurobiological disorder caused by increased excitability of the central nervous system. it is among the causes of the highest morbidity worldwide. migraine has considerable economic and social impact ; affects the quality of life of patients and disrupts work life, social activities and family life. to decrease the frequency and severity of migraine attacks may be the first goal than treating the attacks. the study was designed as a parallel group, add on, randomized controlled experiment in order to observe the effects of breathing techniques on migraine-like headaches, frequency and severity. methods: participants will be divided into 2 parallel arms, intervention and control (treatment as usual). cluster randomization will be performed to prevent intergroup contamination. breathing techniques will be taught to the intervention group by the researcher. both groups will continue to use pharmacotherapy for migraine. both groups will be evaluated with migraine disability level (midas) at the beginning and end of the study. the primary output of the study is to evaluate the effect of breathing techniques on the frequency and severity of attacks in migraine-like headaches. the secondary output is to evaluate the effect of breathing techniques on the midas level. discussion: the results of the study will provide information about the effect of breathing techniques on migraine-like headaches. the results of this study will contribute to the literature, since migraine is among the chronic diseases and pharmacotherapy options are limited.


Eligibility criteria:
inclusion criteria: * are 18-50 age * have a computer and/or smart phone * have an internet connection that can be used at home and at work (with a computer or smart phone) * are volunteer to participate in the research * have frequency of attacks less than 3 months * fulfil diagnostic criteria of migraine like headaches exclusion criteria: * severe anatomical defect in the airway * pregnancy * having any diagnosed psychiatric disease * using psychiatric medication * having speech and hearing problems * having any chronic disease which may be worsening by taking deep breath
limberg and karydakis flap in recurrent pilonidal sinus disease

Conditions: Recurrent Pilonidal Sinus Disease

Summary: it was investigated whether there is a factor that can aid determination of the preferred technique by comparing the early limberg flap and karydakis procedure techniques for the treatment of recurrent pilonidal sinus.

sacrococcygeal pilonidal sinus is common in young men and may recur overtime after surgery. it was investigated whether there is a factor that can aid determination of the preferred technique by comparing the early limberg flap and karydakis procedure techniques for the treatment of recurrent pilonidal sinus.

Eligibility criteria:
inclusion criteria: 1. patients willing to give written informed consent 2. there should be recurrent pilonidal sinus 2. recurrent adult patients (over 18 years of age) undergoing surgery for pilonidal sinus 3. international normalizing ratio (inr) less than 1.5 4. prothrombin time (pt) should be less than 15 s 5. partial thromboplastin (ptt) time should be near normal 6. platelet count should be greater than 50,000 per mm3 to limit the risk of bleeding 7. there must be no infection at the time of surgery - exclusion criteria: 1. patients not willing to give informed consent 2. age less than 16 years 3. patient presenting with conditions mimicking pilonidal sinus 4. diabetes mellitus, renal failure, immunosuppression e.g. were excluded -

Keywords: karydakis procedure limberg flap recurrent pilonidal sinus
current status of diagnosis and treatment of uroepithelial carcinoma

Conditions: Uroepithelial Carcinoma

Summary: a cross-sectional study describing the current status of diagnosis and treatment of uroepithelial cancer in hospitals of different grades in henan province

patients diagnosed with uroepithelial carcinoma attending multiple research center hospitals in henan province from january 1, 2023 to december 31, 2023 a questionnaire was used to collect and analyze the treatment patterns of patients with early versus advanced uroepithelial cancer in different levels of hospitals in henan province.

Eligibility criteria:
inclusion criteria: * adults ≥18 years of age (at enrollment) * histologically confirmed uroepithelial carcinoma * patients with newly diagnosed or completed radical uroepithelial carcinoma in the early stages of uroepithelial cancer/advanced unresectable or with distant metastases of urothelial carcinoma * complete medical history information exclusion criteria: * incomplete medical history and medical records

Keywords: henan province uroepithelial cancer treatment
derivation of an in-hospital cardiac arrest prediction model for patients in intensive care unit

Conditions: In-Hospital Cardiac Arrest

Summary: current studies have shown that hospitalized icu patients have a high risk of ihca, with an incidence of about 0.6-7.8%. early prediction of the occurrence of ihca in severe patients can provide early intervention, prevent the deterioration of the disease, and reduce the incidence of ihca. therefore, researchers wanted to verify the efficacy of mews, news, and cart scores in predicting ihca in icu inpatients, and to establish an early-warning scoring model that could effectively predict the risk of ihca occurrence in icu inpatients during hospitalization.


Eligibility criteria:
ca group inclusion criteria: * occurrence of ihca * hospital stay ≥48h. exclusion criteria: * \<14 years * do not resuscitat * patients hospitalized due to out-of-hospital cardiac arrest * cardiac arrest occurs during the operation * the patients with implanted cardiac pacemaker suffered cardiac arrest due to instrument malfunction. control group inclusion criteria: * without ihca * hospital stay ≥48h exclusion criteria: * \<14 years * leave hospital without medical advice

Keywords: critically ill patients in-hospital cardiac arrest early recognition early warning score
the variability of 25-hydroxyvitamin d response from crystalline 25-hydroxyvitamin d3

Conditions: Vitamin D Deficiency

Summary: the investigators hypothesize that native vitamin d will have more variability in 25(oh)d dose response when compared to a given equipotent dose of 25-hydroxyvitamin d3. this will be a single blind, active control, pharmacokinetic study of 625 μg 25(oh)d given orally or 2500 μg native vitamin d given orally.

single blind, active control, pharmacokinetic study of 625 μg 25(oh)d given orally or 2500 μg native vitamin d given orally.

Eligibility criteria:
inclusion criteria: * ten men and women in each group, * aged 20-60. exclusion criteria: * history of hypercalcemia, * vitamin d supplement use \> 800 iu daily, * bmi \> 30, * gastrointestinal malabsorption (from celiac sprue, colitis, surgery, etc.), kidney disease or liver disease, * use of steroids in any form, * anticonvulsants, * antibiotics, * acute illness, or * vacation planned to "sunny climate"

Keywords: vitamin d
echo: optimizing a group-based school intervention for children with emotional problems

Conditions: Anxiety Depression

Summary: the present study (echo) will promote much needed research and innovation that optimize service provision in first line health services for the alarmingly high number of school children who suffer from clinical and subthreshold levels of anxiety and depression. the effect of different versions of an evidence-based intervention for this group of children will be tested using a cluster randomized design involving 40 schools across norway. the aim is to create a framework that allows more evidence-based psychosocial interventions to be provided at a lower cost to society. echo will provide knowledge about three main evidence gaps for children: (1) the effect of school-based preventive interventions on anxiety and depression; (2) the effect of feedback informed systems, and; (3) the effect and cost-effectiveness of digital health interventions using online sessions and virtual reality technology.


Eligibility criteria:
inclusion criteria: • children scoring one standard deviation or more above population mean using established measures for anxiety and/or depression exclusion criteria: * retardation or language problems * developmental conditions * individual considerations approved by the local pi
a long-term extension study of onabotulinumtoxina (botox®) for urinary incontinence due to neurogenic detrusor overactivity

Conditions: Urinary Incontinence

Summary: this study will evaluate the long-term safety and efficacy of onabotulinumtoxina (botulinum toxin type a; botox®) for the treatment of urinary incontinence due to neurogenic detrusor overactivity in participants who successfully completed study 191622-120 (nct01852045).


Eligibility criteria:
inclusion criteria: * successfully completed participation in study 191622-120 * aged ≥ 5 years to ≤ 17 years at the time of entry into study 191622-120 * regularly using clean intermittent catheterization to empty the bladder exclusion criteria: * myasthenia gravis, eaton-lambert syndrome, or amyotrophic lateral sclerosis * current or planned use of a baclofen pump * current or planned use of an electrostimulation/neuromodulation device for urinary incontinence * use of an indwelling catheter for urinary incontinence instead of using clean intermittent catheterization to empty the bladder * previous or current use of botulinum toxin therapy of any serotype for any urological condition, or treatment with botulinum toxin of any serotype for any other condition since entering study 191622-120
urinary tract infection due to beta-lactamase-producing enterobacteriaceae in children

Conditions: Urinary Tract Infections

Summary: urinary tract infection due to extended-spectrum beta-lactamase producing enterobacteriaceae (e-esbl uti) become a frequent problem. a too large variety in the prescription of antibiotics for e-esbl uti in children and absolute recommendations regarding the optimal treatment of e-esbl is nearly impossible at this time. our aim was to describe the characteristics and treatments of urinary tract infections caused by extended spectrum betalactamase-producing enterobacteriaceae in children.

in this prospective observational study between march 2013 and march 2017, children (0 to 18 years) with esbl-e uti were enrolled in 24 pediatric departments in france. clinical and biological characteristics, risk factors of infection of e-esbl, first and second lines of antibiotic therapies were analyzed. the investigators used the kaplan-meier method to estimate the time to fever defervescence and hospitalization duration, and log-rank test to assess equality of survivor functions. the investigators also analyzed the resistance patterns and molecular characterization of esbl types in the isolates.

Eligibility criteria:
inclusion criteria: * all inpatient or outpatient under 18 years with uti (cystitis or febrile uti) * clinical signs associated with a positive e-esbl in urine culture dependent urine collection method as previously described (stein r, eau/espu guidelines) and an antibiotic treatment targeting this strain. exclusion criteria: * refusal to participate in the study * children with mixed microbial strains and repeated infections were excluded

Keywords: enterobacteria children febrile urinary tract infection cystitis extended-spectrum beta-lactamase-producing enterobacteriaceae
conscious pregnancy: supporting maternal cardiometabolic health with mindfulness

Conditions: Maternal Cardiometabolic Health; Molecular Impact of Psychological Stress and Socioeconomic Adversity; Maternal Inflammatory Markers; Maternal Diabetes; Maternal Behavior; Maternal Distress

Summary: a pilot randomized control trial (rct) to examine the efficacy of a culturally tailored mindfulness intervention upon fasting cardiometabolic factors (including markers of glycemic control) and inflammatory gene expression in n=60 (n=30 intervention, n=30 wait-list control) low-income spanish-speaking latina pregnant women. the study will be conducted in partnership with moms, a nonprofit community organization that serves low-income pregnant and postpartum women.

prenatal health interventions have the potential to shape the future health of both mothers and offspring. given that the latino population is disproportionately affected by high rates of obesity and type 2 diabetes, targeted prenatal health interventions that support latina metabolic health are fundamental to reduce the burden of latino health disparities within and across generations. research in primarily non-hispanic white populations suggests that prenatal mindfulness interventions can not only improve maternal mental health outcomes and well-being, but additionally can support systemic physiological health, such as improved glycemic control and reduced gestational weight gain. however, research on the acceptability and feasibility of mindfulness programs for latino populations is limited, especially among those who are spanish-speaking and affected by poverty. focus groups conducted with this target population, have highlighted a strong interest in mindfulness programs, with a need for novel hybrid instruction format (live classes + digital at-home content). accordingly, the investigators have developed an adapted, hybrid version of the validated 6-week mindfulness awareness practices (maps) training program in spanish and english. here, the investigators plan to pilot and examine the efficacy of this culturally tailored mindfulness intervention upon cardiometabolic factors, including inflammatory gene expression and glycemic control markers, in a low-income spanish-speaking latina pregnant population (n=60; n=30 intervention, n=30 wait-list control). specifically, the investigators will examine the intervention impact on cardiometabolic markers (e.g., fasting glucose and insulin, hemoglobin a1c (hba1c), c-reactive protein (crp), lipids), and inflammatory gene expression measurement. maternal mental well-being, pregnancy and birth outcomes will also be assessed. in addition, the investigators will examine the feasibility and acceptability of pre-post intervention continuous glucose monitoring (cgm) in n=5 mindfulness group participants.

Eligibility criteria:
inclusion criteria: 1. singleton, intrauterine pregnancy 2. 1st or 2nd trimester at enrollment 3. fluent in spanish 4. self-identify as hispanic/latino 5. low-income exclusion criteria: 1. having regular mindfulness practice 2. t1 or t2d diagnosis
pharmacological prophylaxis of post- endoscopic retrograde cholangiopancreatography (ercp) pancreatitis

Conditions: Post-ERCP Pancreatitis

Summary: the investigators aimed to perform a comparative study, evaluating the efficacy of three prophylactic approaches aiming to reduce the risk of post-ercp pancreatitis, using pharmacologic agents with different mechanisms of action (nsaids and/or acetylcysteine) in three different regimens.


Eligibility criteria:
inclusion criteria: * age 18 years and older * diagnosis of choledocholithiasis * indication for ercp procedures * willingness to participate in the study * the ability to sign the informed consent exclusion criteria: * presence of acute pancreatitis or other inflammatory diseases at admission * pregnancy * contraindication for nsaid administration * recent episode of upper digestive bleeding (less than one month) * hypersensibility to antioxidants hypersensibility to antioxidants * the necessity of a prophylactic pancreatic stent insertion * patients' disapproval to take part in the study

Keywords: endoscopic retrograde cholangiopancreatography (ercp) post-ercp pancreatitis (pep) nonsteroidal anti-inflammatory drugs (nsaid's) acetylcysteine (acc)