Kornimate/medical-research-clean huggingface dataset:
the relationship between trunk muscle endurance and physical activity, low back pain and fatigue in young adults

Conditions: Healthy

Summary: the trunk is a kinetic link that facilitates the transmission of force and angular moments between the lower and upper extremities, provides proximal stability for distal mobility, and maintains balance by keeping the body weight within the support surface.while trunk muscle strength is important for maintaining daily living activities, trunk muscle endurance plays an important role in preventing injuries by stabilizing the spine during long-term physical activity and sports activities (2).decreased trunk muscle endurance can result in fatigue and low back pain. low back pain is a major public health problem worldwide. in modern industrial society, the number of low back pain patients is increasing due to sedentary lifestyles, lack of exercise and working conditions.the lifetime prevalence of low back pain has been reported as 84%.80% of low back pain is nonspecific, that is, muscle weakness and ligament-related reasons for unknown reasons(3,4).increasing the endurance of the waist muscles with exercise is used in the treatment of low back pain. from this point of view, while planning our study, we wanted to evaluate whether the decrease in trunk muscles is associated with low back pain and fatigue in young adults.

our research will be carried out in healthy youngs adult volunteers between the ages of 18-24.it is a non-invasive cross-sectional observational study without a control group. no device will be used.the following measurement and evaluation methods will be applied to all individuals who voluntarily agree to participate in the research.first, demographic data will be collected with the patient evaluation form. for trunk endurance measurement, mcgill trunk muscle endurance tests, modified biering-sorensen test and lateral bridge test will be used.these tests measure muscle strength in seconds with examination as described below and do not require a device.fatigue severity scale and roland morris disability form will be filled to evaluate fatigue and lumbar network.physical activity level will be measured with the international physical activity scale.

Eligibility criteria:
inclusion criteria: -voluntarily agree to participate in the research exclusion criteria: * history of musculoskeletal surgery in the last 1 year * diagnosis of lumbar disc herniation, spondylolisthesis, knee ligament and connective tissue damage * scoliosis * pregnancy * malignancy and inflammatory disease

Keywords: trunk muscle endurance low back pain fatigue physical activity
parenteral nutrition support for patients with pancreatic cancer

Conditions: Cancer Cachexia; Pancreatic Cancer

Summary: the purpose of this study is to determine whether the additional nutrition support is improving the nutritional status of patients suffering cancer caxechia or not.

to examine the impact of additional parenteral nutrition (apn) we prospective evaluated 32 pts suffering apc and progressive cachexia. this assay is based on a bioelectrical impedance analysis (bia) as a proven tool for nutritional investigation in patients with chronic disease. phase angle, determined by bia, has been found to be a prognostic indicator in several chronic and malignant conditions, such as hiv, liver cirrhosis, chronic obstructive pulmonary disease lung cancer and pancreatic cancer.

Eligibility criteria:
inclusion criteria: * histological proved pancreatic cancer * progressive cancer cachexia * refractive to enteral supplementation * informed consent exclusion criteria: * prefinal status * septic disease

Keywords: parenteral nutrition cancer cachexia pancreatic cancer
reducing musculoskeletal stresses and work-related injuries among allied health professionals in surgical care

Conditions: Musculoskeletal Injury; Musculoskeletal Illness

Summary: 1. what are the risk factors that contribute to musculoskeletal injuries and fatigue on allied health professionals in surgical care (e.g. scrub nurses, surgical assistants, and circulating nurses)? 2. can the investigators design wearable devices that the investigators can later evaluate?


Eligibility criteria:
inclusion criteria: * ≥ 18 years of age * employed at mayo clinic rochester as surgical assistant, circulating nurse, and scrub nurse (surgical technicians) exclusion criteria, aims 1 and 2: * none

Keywords: ergonomic risk factors allied health professionals surgical care
predominant sensitizations to single bee venom allergens as a risk factor for therapy failure

Conditions: Bee Venom Allergy

Summary: venom immunotherapy (vit) is an established treatment for hymenoptera venom allergy and provides long-term protection from further generalized reactions in almost all patients. however, it is still unclear why bee vit is less effective than vespid vit. the preliminary data show that not only predominant api m 10 sensitization but also other predominant sensitizations may be relevant as risk factors for treatment failure. interestingly, all patients with a predominant api m 10 sensitization who received bee vit with a venom preparation with a supposed lack of api m 10 tolerated sting challenges. therefore, a multicenter study with a sufficient number of patients with treatment failure is urgently required, to clarify if predominant sensitization to a bee venom allergen is a risk factor for treatment failure. if predominant sensitization is a risk factor and caused by underrepresented components in bee venom preparations used for vit, bee venom preparations may be optimized in the future and patients would benefit from a more effective vit.


Eligibility criteria:
inclusion criteria: * legally competent male and female subjects aged from 18 to 70 years with a history of a systemic anaphylactic sting reaction (≥ grade i according to the classification of ring and messmer) after bee stings, who will receive bee venom immunotherapy exclusion criteria: * contraindications to vit
monotherapy versus placebo over 14 or 17 days in healthy and hepatitis c infected adults

Conditions: Hepatitis C, Chronic; Hepatitis C

Summary: this study represents the first administration of gsk625433 in humans. the study is designed to evaluate initial safety and tolerability in healthy adults as well as anti-viral activity in hepatitis c(hvc) infected adults. the way the human body processes gsk625433 will also be investigated.


Eligibility criteria:
inclusion criteria: * healthy males \& females * part 1 ages 18-60 * part 2 ages 18-50 \& 65-80 * within normal weight range given your height * negative urine drug and alcohol test * willing to follow all study procedures exclusion criteria: * any significant abnormal lab, ecg, medical or physical exam finding during screening * allergy to the study drug * excessive alcohol intake * positive hiv or hepatitis b or c result * use of prescription or non-prescription drugs within one week of study start except for birth control * blood pressure meds \& tylenol * pregnant or lactating women

Keywords: gsk625433, hepatitis c, metabolic probe, food-effect, hcv, ftih polymerase,
metabolomic profile and proteasic activity as biomarkers for early detection of arterial vasospas in arterial vasospasm after aneurysmal subarachnoid hemorrhage

Conditions: Subarachnoid Hemorrhage (SAH) From Ruptured Aneurysm

Summary: the subarachnoid hemorrhage (sah) from ruptured aneurysm is a situation that is life-threatening, which is largely dependent on the occurrence of vasospasm from the 4th day after the bleeding. this vasopasm is responsible of clinical morbidity in 30 to 50% of patients. it occurs in 40% of patients with severe sah. despite knowing this, the clinician has no biomarker for identifying patients at risk. the project presented is original and includes a screening method without a priori to identify predictive biomarkers of vasospasm, likely to become therapeutic targets. in secondary objective we will focus on the protease activity of cerebrospinal fluid (csf) and blood as a biomarker potential of vasoconstriction at the waning of subarachnoid hemorrhage. this study will take place over a year prospectively. the inclusion of patients will be in the sar 1 hospital of timone. patients with severe severe sah by rupture requiring the establishment of an external ventricular derivation (evd) will be divided into two groups and compared to one group of patients without necessitating a evd subarachnoid hemorrhage. * group 1: patients with vasopasm * group 2: patient presenting no vasopasm detection of vasopasm was defined using a consensual definition. csf samples (through evd) and blood will be made upon arrival of the patient in intensive care and then between the 3rd and 4th day. as the main criterion, we will identify biomarkers of vasospasm in blood and csf without a priori assumption by metabolomics. analysis will be by chromatography system coupled to a high resolution mass spectrometer. this method does not justify effective calculation because it is a step of generating hypotheses requiring further biological validation based on the identified targets. the secondary criteria, we will study in the blood and csf association between matrix metalloproteinases (mmp) 2 and 9 and the occurrence of vasopasm. results: after comparative analysis of groups 1 and 2 in two phases of the study, we will define a metabolic profile that could identify predictive biomarkers vasopasm.


Eligibility criteria:
inclusion criteria: * patients with severe severe sah by rupture requiring the establishment of an external ventricular derivation (evd) will be divided into two groups * group 1: patients with vasopasm * group 2: patient presenting no vasopasm exclusion criteria: * patients presenting an infectious or carcinologic meningitis
treatment of idiopathic membranous nephropathy with tripterygium wilfordii plus steroid vs tacrolimus plus steroid

Conditions: Idiopathic Membranous Nephropathy

Summary: the purpose of this study is: to explore the potential role of tripterygium wilfordii plus steroid in the treatment of membranous nephropathy. to investigate the safety and tolerability of tripterygium wilfordii plus steroid

idiopathic membranous nephropathy is the most common cause of nephrotic syndrome in adults. over the past decade, a number of studies have reported therapeutic efficacy for treatment with tacrolimus plus steroid in patients with nephrotic syndrome including patients with membranous nephropathy. this study will evaluate the safety and effectiveness of a traditional herbal extraction, tripterygium wilfordii, plus steroid in reducing the amount of protein in the urine in patients with membranous nephropathy. a hundred patients with biopsy-proven membranous nephropathy will be recruited. they will be screened with a medical history, physical examination, blood tests, and an examination for infection, cancers, and other conditions that can cause membranous nephropathy. the investigators plan to conduct an open-label study of the efficacy and safety of tripterygium wilfordii in the treatment of membranous nephropathy. half of them will be treated with oral tripterygium wilfordii plus steroids for 6 months, followed by 6 months of maintenance, and the other half treated with tacrolimus plus steroid as positive contrast. proteinuria, renal function will be monitored. complete remission is defined as 24-hour urinary protein excretion to less than 0.4 mg/day and serum albumin\>35g/l. this study will explore the potential role of tripterygium wilfordii in the treatment of membranous nephropathy, it's cost less .

Eligibility criteria:
inclusion criteria: 1. biopsy-proven idiopathic membranous nephropathy 2. nephrotic syndrome with proteinuria ( \> 3.5 g/day) and serum albumin \< 30 g/dl 3. age 18-65 years with informed consent exclusion criteria: 1. patient with elevated serum creatinine concentration 2. prior therapy with sirolimus, csa, mmf, or azathioprin, cytoxan, chlorambucil, levamisole, methotrexate, or nitrogen mustard in the last 90 days 3. active/serious infection 4. patient with hepatitis b surface antigen or who is hepatitis c antibody positive 5. patient who is diabetic 6. patient is allergic or intolerant to macrolide antibiotics or tacrolimus

Keywords: idiopathic membranous nephropathy treatment fk506 tripterygium wilfordii
educating the educator to reduce risk of dance student injury

Conditions: Injuries

Summary: a group of dance educators will attend two dance injury prevention workshops hosted by the harkness center for dance injuries (hcdi), nyu langone medical center, during which participants will learn strategies to help them train their students in safe ways and impart injury prevention information through their dance classes to their students. the educators will take pre- and post-workshop tests to assess knowledge and perceptions of dance medicine. several weeks later, participants will take a follow-up survey to assess knowledge implementation and workshop effectiveness.


Eligibility criteria:
inclusion criteria: * teach dance to children in at least one private dance school * must be able to receive email and complete a survey online * must believe that students lack access to dance injury prevention resources * must teach at least one group of students that takes class from them a minimum of twice a week and must teach those students regularly in september and october, 2017. exclusion criteria: * under the age of 18

Keywords: dance injuries injury prevention workshops motor skill theory gross motor skills
quality of medical history taking and diagnostic accuracy

Conditions: Diagnostic Error

Summary: this prospective randomized simulator-based single-blind trial aimed to investigate the effects of initial cues and history taking skills on diagnostic accuracy

diagnostic errors are a relevant health-care problem. as medical history taking is usually the first step in a patient's assessment its quality is most likely a first and important barrier against diagnostic errors. there are, however, only limited data on the association of the quality of medical history taking and diagnostic accuracy.this prospective randomized simulator-based single-blind trial aimed to investigate the effects of initial cues and history taking skills on diagnostic accuracy. 198 medical students (135 females) were given the task to assess a patient presenting with simulated acute pulmonary embolism. participants were randomized to six versions of the scenario differing only in the initial cues, i.e. in the reply of the patient to the initial question about the reason for his visit. in three of six versions, initial cues were restricted to thoracic symptoms (chest pain, dyspnoea, or combination of both). in the remaining three versions, initial cues consisted of thoracic and extra-thoracic (leg pain, immobilization) symptoms. the primary outcome was diagnostic accuracy. the mannequin was equipped with a speaker in its head that broadcasts the voice of a remote operator (experienced physician) allowing verbal interaction of the participants with the "patient". the "patient" did not speak unless asked and responded to all participants' questions during history taking according to a pre-defined checklist.

Eligibility criteria:
inclusion criteria: * 4th year medical students participating in voluntary simulator-based workshops exclusion criteria: * decline to give written informed consent

Keywords: medical simulation diagnostic error pulmonary embolism
recurrent low back pain: linking mechanism to outcomes (rct)

Conditions: Low Back Pain

Summary: the purpose of this randomized clinical trial of low back pain exercise programs is to determine if trunk control can be changed by core stabilization exercises. the proposed mechanism of pain reduction and functional improvement of core stabilization exercises is that it enhances trunk movement and muscle control. this study will provide preliminary evidence of the link between patient outcomes and treatment mechanisms. the investigators hypothesize that: * both treatment groups will demonstrate significant improvements in pain and function; * only subjects in the core stabilization group will demonstrate significant improvements in trunk movement and muscle control.


Eligibility criteria:
inclusion criteria: 1. duration of the current episode less than 3 months, 2. average pain intensity over past 2 weeks greater than 4 on an 11 point (0 = no pain, 10 = worst pain ever) verbal pain rating scale, 3. self-report global function less than 80% (0-100 %, 100% = normal pain free function) 4. oswestry index \> 19% 5. no physical therapy or chiropractic treatment for the current episode of low back pain. 6. clinical diagnosis of poor trunk control/ clinical lumbar instability needs to be met based upon completion of specific physical therapy examination finding exclusion criteria: 1. permanent structural spinal deformity (e.g., scoliosis), 2. spinal fracture or history of spinal fracture, 3. osteoporosis, 4. inflammatory joint disease, 5. signs of systemic illness or suspected non-mechanical lbp (spinal tumor or infection), 6. previous spinal surgery, 7. frank neurological loss, i.e., weakness and sensory loss in a nr distribution, 8. pain or paresthesia below the knee, 9. leg length discrepancy of greater than 2.5 cm, 10. history of neurologic disease that required hospitalization, 11. active treatment of another medical illness that would preclude participation in any aspect of the study, 12. pregnancy, 13. vestibular dysfunction, 14. extreme psychosocial involvement 15. allergies to medical tape or adhesives 16. body mass index greater than 30 kg/m2

Keywords: low back pain core stabilization trunk muscle exercises physical therapy rct
toripalimab combined with anlotinib for patients with advanced, relapsed, or refractory gastric, or esophagogastric junction cancer (egjc)

Conditions: Gastric or Gastro-oesophageal Junction Carcinoma; Advanced, Relapsed Gastric or Gastro-oesophageal Junction Carcinoma; Second-line Therapy

Summary: patients were aged \>18 years with histological confirmed gc/egjc and were refractory to the first line of therapy. additional eligibility requirements included: ≥1 measurable disease at baseline per response evaluation criteria in solid tumors, version 1.1 (recist v 1.1); eastern cooperative oncology group performance status of 0 or 1; or life expectancy of ≥ 3 months and adequate organ function. the main exclusion criteria were interstitial lung disease, pulmonary fibrosis, active or prior autoimmune disease or active hepatitis, or history of anlotinib or any other pd-l1/pd-1 antagonist treatment. patients with abdominal fistula, diverticulitis, gastrointestinal ulcerative disease or perforation, or abdominal abscess within the prior 4 weeks were also excluded. this study was an open, exploratory single-arm, phase ii trial. enrolled patients received anlotinib (12mg, po. qd, d1-14) combined with toripalimab (240 mg, inv, over 30 min once every 2 weeks).


Eligibility criteria:
inclusion criteria: patients were aged \>18 years with histological confirmed gc/egjc and were refractory to the first line of therapy. additional eligibility requirements included: ≥1 measurable disease at baseline per response evaluation criteria in solid tumors, version 1.1 (recist v 1.1); eastern cooperative oncology group performance status of 0 or 1; or life expectancy of ≥ 3 months and adequate organ function. exclusion criteria: the main exclusion criteria were interstitial lung disease, pulmonary fibrosis, active or prior autoimmune disease or active hepatitis, or history of anlotinib or any other pd-l1/pd-1 antagonist treatment. patients with abdominal fistula, diverticulitis, gastrointestinal ulcerative disease or perforation, or abdominal abscess within the prior 4 weeks were also excluded.
clinical study in post-operation treatment of cervical cancer

Conditions: Cervical Cancer

Summary: the purpose of the research is to evaluate the effect of additional chemotherapy in postoperation therapy of cervical cancer patients with risk factors (big tumor, deep invasion or tumor thrombi in the vascular system).

cervical cancer has a very high morbidity. many patients need additional therapy after surgery in order to elevate the survival rate and life quality. in this research, we are going to give additional therapy to patients who have big tumor, deep invasion or tumor thrombi in the vascular system after surgery. randomized control method will be used in this research, in order to compare the survival rate and side effects between radiation therapy only, concurrent chemoradiotherapy, and concurrent chemoradiotherapy with additional chemotherapy. 3d-crt and topotecan will be used in this research.

Eligibility criteria:
inclusion criteria: 1. patients who underwent the cervical cancer radical surgery in three months have higt risk factors which including deep stromal invasion,large primary tumour and/or lymphovascular spase invasion; 2. squamous carcinoma; 3. age\<70; 4. gynecologic oncology group (gog):0-2. exclusion criteria: 1. negative nodes,surgical margin,and/or parametrium; 2. no serious damage to the liver and kidney function, no hypertension,diabetes and other effects of therapy complications.

Keywords: cervical cancer postoperation chemotherapy radiotherapy