Kornimate/medical-research-clean huggingface dataset:
a dynamic evaluation of chronic heart failure prognosis: the mecki score

Conditions: HF - Heart Failure

Summary: the project is dedicated to the improvement of our capability to provide a precise and personalized prognosis in heart failure (hf) patients in stable conditions. the metabolic exercise test data combined with cardiac and kidney indexes (mecki) score is one of the 3 hf prognostic models recommended by the 2021 european hf guidelines and it is considered the most powerful prognostic tool available. mecki score integrates cardiopulmonary exercise test (cpet) data with easy-to-obtain clinical, laboratory, and echocardiographic variables. it is based on 6 parameters: peak oxygen intake (peakvo2), minute ventilation/carbon dioxide production (ve/vco2 slope), hemoglobin (hb), left ventricle ejection fraction (lvef), kidney function by modification of diet in renal disease (mdrd) formula, and sodium (na+). the aim of the present project is to assess the day-by-day mecki score variability, cpet parameters interobserver variability, characterization of hf patients who change mecki score values in 6 and 12 months, and the prognostic meaning of time dependent mecki score changes.

this is a low-intervention multicenter clinical trial aim at evaluating the role of time dependent prognostic parameters changes, moving from the single shot evaluation to dynamic analysis. each participant center will perform patients' recruitment and follow up. at the baseline visit, cpet-related variables, echocardiographic, ecg, therapy and blood chemistry data will be collected. the baseline cpet will be repeated within 2 weeks. patients will perform 4 follow up visits at 6, 12, 18 and 24 months after the baseline visit. at every study step, study procedures aimed to calculate mecki score will be performed: * echocardiography (left ventricle ejection fraction - lvef) * blood sample (na+, mdrd, hb) * maximal ramp protocol cpet (peakvo2, minute ventilation/carbon dioxide production (ve/vco2) slope - ve/vco2 slope)

Eligibility criteria:
inclusion criteria: * previous or present hf symptoms (nyha functional class i-iv, stage b and c of acc/aha classification) * history or presence of left ventricular ejection fraction (lvef)\<40% * unchanged hf medications for at least three months * ability to perform a cpet * no major cardiovascular treatment or intervention scheduled exclusion criteria: * history of pulmonary embolism * moderate-to-severe aortic and mitral stenosis * pericardial disease * severe obstructive lung disease * exercise-induced angina * significant ecg alterations, or presence of any clinical comorbidity interfering with exercise performance

Keywords: cardiopulmonary exercise testing- cpet metabolic exercise cardiac kidney indexes (mecki) score
heart and renal failure in hip fracture surgery

Conditions: Hypotension; Hip Fractures; Renal Insufficiency; Heart Injuries

Summary: patients with acute hip fractures are old and vulnerable. with a majoriry classified as being asa 3 or more. frequently they receive spinal anesthesia perioperatively inducing hypotension. even a short hypotensive period may induce postop cardiac t roponint leakage as well as renal failure noted by changes in serum creatinin or cýstatin c this will be investigated and correlated to intraoperative hypotension as step one. preliminary this will be followed by an intervention with vasopressor treatment perioperatively to preserve an adequte mabp

patients with acute hip fractures are old and vulnerable. with a majoriry classified as being asa 3 or more. frequently they receive spinal anesthesia perioperatively inducing hypotension. even a short hypotensive period may induce postop cardiac t roponint leakage as awell as renal failure noted by changes in s creatinin or cýstatin c this will be investigated and correlated to intraoperative hypotension as a step one. preliminary this will be followed by an intervention with vasopressor treatment perioperatively to preserve an adequte mabp

Eligibility criteria:
inclusion criteria: * hip fracture patient to be operated upon classified as being asa 3 or more exclusion criteria: * not forfilling inclusion criterias
the link between anemia and deficits in memory and attention in individuals with sickle cell disease

Conditions: Sickle Cell Disease

Summary: sickle cell disease is an inherited blood disorder that affects red blood cells (rbcs). people with sickle cell disease frequently experience anemia, or a low number of rbcs. rbcs are responsible for carrying oxygen to the brain and other body tissues that need oxygen to function properly. the purpose of this study is to determine what changes, which were possibly caused by anemia, exist in the brains of individuals with sickle cell disease.

the role of rbcs is to carry oxygen from the lungs to the brain and other body tissues. individuals with anemia have unusually low numbers of rbcs. they also often have difficulty concentrating and remembering information, which is likely caused by a reduced oxygen supply to the brain. previous research has shown that correcting anemia in patients without sickle cell disease improved their memory and attention. the purpose of this study is to examine any abnormal changes in the brains of individuals with sickle cell disease and to determine whether these changes are related to reduced memory and attention capabilities. participants will attend one study visit. during this visit, a brain magnetic resonance image (mri) will be performed while participants complete neuropsychological tests that measure memory, attention, and organizational ability. there will be no follow-up visits. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
inclusion criteria: * diagnosis of sickle cell disease exclusion criteria: * pregnancy * claustrophobia * mass lesion (e.g., meningioma, cyst, or spinal block) * need for life support constant monitoring * any unstable condition that is likely to require resuscitation * presence of a pacemaker or other iron-containing magnetic substances in the body

Keywords: mri neuropsychology
aquatic power training

Conditions: Knee Osteoarthritis

Summary: knee osteoarthritis (oa) accounts for a significant proportion of mobility limitations and is one of the most disabling problems facing the growing population of older adults. the purpose of this research is to reduce disablement of older adults with symptomatic knee osteoarthritis.

aquatic based training can offer many of the same benefits associated with a land based exercises but water has certain properties that provide a more gentle and welcoming environment for exercising. buoyancy in water counteracts gravity to support the weight of the subject and decrease the forces put on the joints. viscosity of water can provide resistance proportional to the effort exerted and with gentle friction enhancing proprioceptive feedback. immersing in warm water can cause an increase in body temperature due to specific heat and thermal conductivity, which can cause blood vessels to dilate. in addition, hydrostatic forces reduce edema, increasing venous return and healthy circulation. \[prins, 1999\]; \[wilder, 1998\] studies have shown that water based exercise has been proven to significantly decrease pain in people with knee osteoarthritis compared to those in a land based exercise program. \[silva, 2003\] in comparing an aquatic physical therapy session to a no intervention group the aquatic program resulted in less pain, improved physical function, quality of life, and strength. \[hinman, 2007\] the purpose of this research study is to determine whether an aquatic therapy program aimed at increasing muscle power will be effective in improving knee symptoms and mobility in men and women with symptomatic knee osteoarthritis. the purpose of this study is to assess the efficacy of aquatic power training for improving mobility limitations, disability and quality of life in older adults with symptomatic knee oa. hypothesis 1: in older adults with symptomatic knee oa, a 6-week aquatic power training intervention will reduce lower limb mobility limitations (400m walk time). hypothesis 2: in comparison to baseline measures, at 6-week follow-up, there will be improvements in a) lower limb function (llfdi), b) quality of life (koos knee qol),c) knee oa specific pain (koos pain) scores, and d) vastus lateralis muscle bulk (thigh muscle). these changes will be sustained at 12 week follow-up.

Eligibility criteria:
inclusion criteria: * age 50 or older * symptomatic knee osteoarthritis (knee osteoarthritis diagnosed by the american college of rheumatology criteria and frequent knee symptoms) exclusion criteria: * bilateral knee replacement * acute or terminal illness * unstable cardiovascular condition or other medical conditions that may impair ability to participate such as pulmonary disease requiring use of supplement oxygen, or lower limb musculoskeletal surgery in the past 6 months * unwilling to be in a pool (approximately 4 feet deep) * 400m walk time equal to or slower than the median for sex and decade: m 50's 250.2 60's 289.9 70's+ 290.8 f 50's 315.9 60's 305.2 70's+ 292.5

Keywords: osteoarthritis knee pain power training rehabilitation
ozone reaction products and skin health

Conditions: Skin Health

Summary: this is a randomized controlled human exposure study. investigators aim to investigate the products of ozone-sebum reactions and their acute effects on skin health of healthy young adults.

the investigators will conduct a randomized, controlled human exposure study involving 40 healthy young adults in shanghai, china. each participant will have both forearms simultaneously exposed-one in a clean air chamber and the other in an ozone chamber-for 2 hours. the ozone concentration at the ozone chamber inlet will be maintained at 200 ppb. the temperature and relative humidity in both chambers will be maintained at 27±2℃ and 45%±5%, respectively. health examinations will be conducted at three time points: immediately before exposure, immediately after exposure, and 24 hours after exposure. these examinations will include skin measurements and sampling.

Eligibility criteria:
inclusion criteria: * living in shanghai during the study period; * having healthy skin conditions on both forearms. exclusion criteria: * subjects with a history of smoking and alcohol abuse; * subjects with a regular use of medication and dietary supplements within 2 months prior to enrollment; * subjects with severe skin diseases, such as atopic dermatitis, eczema, or severe acne; * subjects with allergic diseases, such as allergic rhinitis, allergic asthma, or atopy, or history of allergic reactions within 2 months prior to enrollment; * subjects with cardiovascular diseases, such as congenital heart disease, pulmonary heart disease, or hypertension; * subjects with respiratory diseases, such as asthma, acute or chronic bronchitis, or pneumonia; * subjects with chronic diseases, such as diabetes, chronic hepatitis, or kidney disease; * subjects with cutaneous abnormalities on forearm, such as severe pigmentation, multiple nevus, or tattooing; * subjects who underwent cosmetic intervention on forearms within 2 months prior to enrollment, such as whitening treatments, uv exposure therapies, depigmentation procedures, or tanning; * females in pregnancy or lactation status.

Keywords: ozone reaction products skin health
evaluation of the niostem headset for hair growth and hair quality

Conditions: Alopecia Areata; Androgenetic Alopecia; Pattern Baldness

Summary: this double-blind, randomized, placebo-controlled clinical trial evaluates the niostem headset, an electronic device designed to support hair growth, reduce hair loss, and improve hair quality. a total of 101 adult participants (20 female, 81 male) aged 18-55 were enrolled. participants used the device daily for 30 minutes over a six-month period. the primary objective is to assess skin tolerability, and secondary objectives include evaluating usability and efficacy through validated questionnaires, trichoscan hair analysis, and digital imaging under dermatological supervision.

the study is conducted by dermatest gmbh from october 2023 to september 2024 under dermatological supervision. the niostem headset is a home-use electronic device applied daily for 30 minutes following standardized protocols. the primary endpoint is skin tolerability, with secondary endpoints assessing usability and potential effects on hair quality and growth. dermatological evaluations occur at baseline, 3 months, and 6 months. quantitative assessments include trichoscan imaging and digital macro photography, while subjective feedback is collected using validated self-report questionnaires. participants are adults experiencing pattern hair loss-classified as norwood stages 2-5 (men) and ludwig stages i-ii (women). exclusion criteria include scalp conditions, pregnancy, ongoing medication use, and dermatological or psychiatric disorders. the study aims to assess the safety and user experience of a non-chemical, wearable neuromodulation device for cosmetic scalp and hair applications.

Eligibility criteria:
inclusion criteria: healthy male or female volunteers between 18 and 55 years of age dermatologically confirmed pattern hair loss (norwood stages 2-5 for men; ludwig stages i-ii for women) willingness to comply with daily use of the niostem headset for 6 months no relevant scalp or dermatologic disease at baseline signed informed consent exclusion criteria: scalp conditions (e.g., psoriasis, eczema, dermatitis) use of topical or systemic hair growth treatments within 3 months prior to study pregnancy or breastfeeding diagnosed psychiatric or neurologic disorders participation in another clinical study in the past 30 days known allergy to electrode gel or materials in the device

Keywords: hair loss alopecia androgenetic alopecia hair growth hair density hair quality niostem headset transcutaneous stimulation dermatology home-use device scalp stimulation non-invasive treatment clinical trial pattern baldness
ds-5565 phase iii study for post-herpetic neuralgia

Conditions: Post-Herpetic Neuralgia

Summary: investigate the efficacy and safety of ds-5565 in subjects with post-herpetic neuralgia (phn) in comparison to placebo

\[double blind phase\] the primary objective is to compare change in the average daily pain score (adps) from baseline to week 14 in asian subjects with phn receiving ds-5565 versus placebo. \[open extension phase\] the objective is to assess the long-term safety and efficacy of ds-5565 in subjects with phn.

Eligibility criteria:
inclusion criteria: * phn defined as pain present for more than 3 months after herpes zoster skin rash at screening * at screening, a pain scale of ≥ 40 mm exclusion criteria: * previous use of neurolytic block

Keywords: post-herpetic neuralgia developmental phase iii
the effect of manual therapy versus kinesio taping on tension-type headache in jouf university female students

Conditions: Tension Type Headache

Summary: patients suffering from tension type headache (tth) report emotional and functional deficits (missing work, sleep disorders, emotional stability) and are susceptible to pharmaceutical abuse. cervical muscle training, posture correction, spinal mobilization, and other physical therapy modalities may help alleviate symptoms. this study will aim to compare the effect of manual therapy and kinesio taping on tension-type headache.


Eligibility criteria:
inclusion criteria: * students between the ages of 18 and 25 will be enrolled in the study if they have tension type headache based on the ihs headache classification: a headache that occurs at least 15 days per month for more than 3 months (≥ 180 days per year) and lasts for hours or is continuous. the headache exhibits at least one of the following characteristics: 1. bilateral location, 2. pressing/tightening (non-pulsating) character, 3. mild or moderate intensity that is not exacerbated by routine physical activity such as walking or ascending stairs, and both of the following: 1. no more than one of photophobia, phonophobia, or mild nausea, and 2. no moderate to severe nausea or vomiting. exclusion criteria: * reumatoid arthritis, suspected malignancy, pregnancy, regular use of triptans, ergotamines, or opioids on ≥ 10 days/month or simple analgesics on ≥ 15 days/month for ≥ 3 months, or physical therapy treatment within 2 months prior to enrollment in the study.

Keywords: tension type headache manual therapy kinesio taping
effects of exercises in ms on postural control with dual task

Conditions: Multiple Sclerosis

Summary: multiple sclerosis is a progressive neurological disease that associated with demyelinization and axonal damage. decreased postural control is one of the initial symptom of disease. improving postural control in people with neurological impairment is a common goal of physiotherapy. doing exercises in water or land are examples for effective solutions. pilates and aquaplyometric exercises are some of these approaches. performing daily activities at the same time requires dual tasking or multi tasking. dual tasking is frequently impaired in ms. the aim of the study was to determine effect of combined pilates and aquaplyometric exercises on postural control with or without dual task in patients with multiple sclerosis.

ms patients with decreased postural control will be enrolled eight-week, 45 minutes combined pilates and aquaplyometric exercise programme. postural control, hand dexterity and other functional parameteres will assess besaline and at the eighth week of exercise programme by the physiotherapist. postural control will evaluate with and without dual task.

Eligibility criteria:
inclusion criteria: * being over 18 years old * ability to walk independently or with single walking aid * having stable symptoms exclusion criteria: * being acute or unstable phase of disease * having edss score\>6 * insuitable for the pool (incontinance, dermatological disease etc.)

Keywords: multiple sclerosis pilates aquatherapy postural control dual task
the effect of preoperative oral prednisone on the operative field during nasal polypectomy.

Conditions: Nasal Polyps

Summary: this study aims to determine if a short course of oral prednisone helps to improve the operative field and ease of surgery by minimizing bleeding during nasal polypectomy surgery.

this study will be conducted as a double blinded randomized control trial and aims to recruit about 34 patients (17 patients per arm). patients will be randomized to receive either prednisone 50 mg po x10 days or an identical looking placebo x10 days. photographs of the polyps will be taken prior to the intervention, on the day of surgery and in the follow-up visit. symptom survey (snot22) will also be administered at these same time points. blood loss will be determined volumetrically from the suction canister and by using the wormald surgical field grading scale. surgeons will also complete a survey postoperatively evaluating visibility, difficulty and ease of surgery. at 2 weeks, 1 month, 3 months and 6 months, patients will again fill out the sino-nasal outcome test - 22 (snot-22) and the surgeon will do an endoscopic assessment by using the peri-operative sinus endoscopy (pose) scoring system .

Eligibility criteria:
inclusion criteria: * all patients with severe obstructing nasal polyps scheduled for surgery. exclusion criteria: * patient unable to tolerate side effects of prednisone * uncontrolled diabetes mellitus * hypertension * previous congestive heart failure * acute/chronic systemic infection * history of hypersensitivity to prednisone * history of cataracts or glaucoma

Keywords: nasal polyps steroids prednisone nasal polypectomy blood loss, surgical
safety and effectiveness of botulinum toxin in elderly patients with dementia and muscle stiffness

Conditions: Dementia; Paratonia

Summary: aim of the study is to perform a pilot study to assess the impact of botulinum toxin on muscle tone, and caregiver burden in individuals who are cognitively impaired and who are fully dependent. the primary objective is to confirm proof of principle that paratonic rigidity and the consequences associated with it can be reduced with injection of botulinum toxin injections resulting in reduced care-giver burden. the secondary objectives are to determine optimal time points for evaluation of efficacy in this patient population and whether the time period is sufficient for washout of botulinum toxin effect; determine most salient and sensitive outcome measures; identify obstacles in data gathering; and lastly, to determine feasibility of battery of assessments in this pilot study.


Eligibility criteria:
inclusion criteria: * severe cognitive impairment (complete dependency in all activities of daily living (adls) * diagnosis of alzheimer's disease, vascular dementia,or frontotemporal dementia * score\> 3 on the paratonic assessment instrument, with paratonic rigidity in an arm(s) interfering in the provision of care exclusion criteria: * alternate etiologies for increased tone * botulinum toxin 6 months preceding the study

Keywords: dementia paratonia caregiver burden botulinum toxin
blood flow change after free flap surgery in diabetic patients

Conditions: Diabetes

Summary: we aim to evaluate the flow change of arterial anastomosis site during free flap surgery in diabetic patients.

objective: flow change of arterial anastomosis site during free flap surgery in diabetic patients. background: no research was published about flow change of arterial anastomosis site of the free flap during surgery. plan: using duplex sonography, various parameters related flap perfusion will be evaluated before and after the administration of alprostadil.

Eligibility criteria:
inclusion criteria: 1. plan to receive free flap transfer under general anesthesia 2. age: \>=18 and \<80 years old 3. history of diabetes mellitus 4. administration of alprostadil during surgery 5. volunteer, who are provided written informed consent prior to study participation exclusion criteria: 1. refuse the participation of study 2. \>= american society of anesthesiologist physical status iv 3. use of any vasopressor or inotropic for hemodynamic instability before participation of study 4. inappropriate subjects who are identified by researchers