Kornimate/medical-research-clean huggingface dataset:
single-stapled double purse-string technique for colorectal anastomosis

Conditions: Colo-rectal Cancer

Summary: a single-arm, single-center prospective study of a novel double purse-string technique for constructing the colorectal anastomosis in robot-assisted laparoscopic resection of the sigmoid colon for cancer.

in all, 30 consecutive patients will be enrolled. the first 5 will be regarded as a pilot series for testing and aligning the study setup. the next 25 patients will form the study group. the clinical outcomes will be compared with historical control patients from our own department. safety and feasibility will be assessed by short-term clinical outcomes.

Eligibility criteria:
inclusion criteria (all must be fulfilled): * verified cancer of the sigmoid colon * planned elective robot-assisted laparoscopic resection of sigmoid colon with primary anastomosis * operation with curative intent exclusion criteria: * not legally competent and/or \< 18 years old * not able to comprehend information and/or give written consent

Keywords: robot
social support and enhanced fear extinction

Conditions: Fear; Anxiety

Summary: university of california, los angeles researchers will recruit healthy participants and anxious participants (those diagnosed with social anxiety disorder) age 18-55 years old to participate in a study examining whether the ability of social support figure reminders to enhance the extinction of fear in healthy participants extends to those with anxiety disorders. after being recruited from the ucla community (healthy participants, n = 50) or referred by treatment providers at the anxiety and depression research center at ucla (anxious participants, n = 50) and undergoing a telephone screening and in-person screening, 100 participants will be enrolled in the study, with an expected recruited 150 to reach this number. during the experiment, all participants will undergo the same procedures: undergoing a fear extinction procedure in which threatening cues--cues that predict electric shock--will be paired with either an image of a social support figure (provided by participants) or an image of a smiling stranger. these pairings will be presented repeatedly in the absence of shock in order for fear extinction to occur. participants will return for a follow-up test to determine if fear extinction was successful.


Eligibility criteria:
inclusion criteria: * healthy adults 18 to 55 * fluent in english * no history of mental illness (healthy participants: including anxiety, depression, phobia, or any other mental health related disorder diagnosed by a mental health professional) * diagnosis of social anxiety disorder (anxious participants: allowed co-morbid disorders include depression, other anxiety disorders, and ptsd) exclusion criteria: * pregnant or planning to become pregnant during the experiment period * presence of chronic mental illness (healthy participants: as determined by the report of a past diagnosis of mental illness by a physician or psychologist and/or the prescription of medication related to mental health disorder; including anxiety, depression, phobia, or any other diagnosed psychological disorder) * presence of non-allowed co-morbid disorders (anxious participants: including, bipolar disorder, psychosis, substance use disorder, neurological disorder, and/or obsessive-compulsive disorder) * current and regular use of prescription medications related to mental health disorders

Keywords: social support fear extinction
effect of beetroot juice supplements on lower-limb strength in females

Conditions: Muscular Endurance

Summary: this study aims to evaluate the effects of beetroot juice supplements on lower-limb strength and muscular endurance in physically active women, due to the presence of no3- in beetroot juice.

beetroot juice (bjr) is used as an ergogenic aid, but no study has analyzed its' effects on explosive force production in physically active women. it has been proposed that females could blunt reduction of no2- to no based on a higher oxidative skeletal muscle phenotype than males. however, it has been observed a higher increase on plasma no2- levels after supplementation compared to and a greater enhancement on muscle contractile function. based on the absence of any study that has analyzed the effect of no3- supplements on jump ability and power production on weightlifting on female population; the purpose of this study will be to investigate the possible ergogenic effect of bjr on physically active women on explosive force production and muscular endurance in a lower-limb body weightlifting protocol, due to the presence of no3- in bjr and its effects.

Eligibility criteria:
inclusion criteria: * physically active females with 18-30 years of age * more than 6 months on rt training programs * be familiarized with back squat, leg press and leg extension exercises * not consuming any type of nutritional supplement or anabolic substances in the previous three months or during the study * not suffering from a musculoskeletal injury that could interfere with the exercise protocol during the investigation exclusion criteria: * none

Keywords: explosive force production beetroot juice beetroot muscular endurance
a multicenter, prospective observational study to evaluate the incidence of delayed-onset nodules of yvoire y-solution 360, yvoire y-solution 540 or yvoire y-solution 720 injected into the facial skin layer.

Conditions: Healthy Condition

Summary: this is an observational study to evaluate the incidence of delayed-onset nodules of yvoire y-solution 360, yvoire y-solution 540 or yvoire y-solution 720 injected into the facial skin layer.


Eligibility criteria:
inclusion criteria: * planned for yvoire y-solution 360 or 540 or 720 filler injection in facial area (except middle of the forehead, lips) for the volume enhancement or anti-wrinkle treatment. * male and female of 19 years or above age. * informed consent to participate in the study. * able to participate throughout the study period. exclusion criteria: * prohibited in the product label. * have active or infectious skin disease in injection area. * autoimmune disease or hiv infected patient. * received immunosuppressive therapy within 2 weeks. * previously experienced delayed-onset nodule after filler injection in facial area. * previously experienced hypertrophic scar or keloid. * have participated in an interventional clinical investigation within 30 days or plan to participate one during the study period. * ineligible for this clinical investigation as per investigator's discretion.
maxillary segmental distalization using digitally printed appliances

Conditions: Class II Malocclusion

Summary: evaluation of maxillary segmental distalization using infrazygomatic versus palatal digitally printed skeletal anchored appliances.

ethical approval all selected patients will be informed about the aims and characteristics of the study, the potential risks and benefits and the option of withdrawing from it whenever they desire. then all patients will sign the informed consent document. all patients will be informed about the results after finishing. all selected patients' personal data and details will be held and handled confidentially and privately in the orthodontic department, faculty of dentistry, mansoura university. trial design patients will be randomly allocated into two groups as follow: 1. first group: buccal segmental digitally printed maxillary distalizer (infrazygomatic mini-implant izc). 2. second group: palatal segmental digitally printed maxillary distalizer. the buccal segmental distalizer will take the anchorage from infrazygomatic miniscrews. the distalizer will be composed of digitally printed metal shell which is bonded to the palatal surface of the whole posterior segment. transpalatal arm will connect the two sides to avoid buccal tipping during distalization. the distalization will be done by placing chain elastics from the miniscrews to the hook present in the mesial aspect of the appliance. the palatal segmental distalizer will take anchorage from miniscrews placed in the anterior palate. the appliance will be bonded to the palatal surface of the posterior segment and containing two anterior and two posterior hooks. the distalization will be performed by using chain elastics between the anterior and posterior hooks. force: 300-350 gram per side which will be measured using force gauge. a follow-up session will be scheduled every 3weeks, and the appliance will be removed in both groups after the patient reach a class i relationship. for each patient, two lateral cephalograms will be obtained: one preoperatively and another after completion of distalization.

Eligibility criteria:
inclusion criteria: * patients age (13- 18) years. * full permanent dentition except third molar. * class ii malocclusion with at least an end-on class ii molar relationship bilaterally. * normal or short lower facial height. exclusion criteria: * systemic conditions that may interfere with the treatment. * bad habits that might jeopardize the appliance. * transverse discrepancy. * previous orthodontic treatment.

Keywords: class ii maloccluusion, miniscrew
validation of a novel thoracic neoplasm radiotherapy image guidance technique: a pilot study

Conditions: Lung Cancer

Summary: the overall, broad objective of this study is to pilot the bsd technique. the specific purpose of this particular study is to generate pilot data to validate several crucial steps of the bsd technique, in particular steps 1, 2, and 4. radiation treatments will proceed per standard of care, and will not be modified in any way during this protocol. this study is a non-treatment protocol.


Eligibility criteria:
inclusion criteria: * any thoracic neoplasm scheduled to undergo radiation therapy * 18 years or older * must be treated with radiation as part of standard of care * able to tolerate the mouthpiece for spirometry and video glasses * ability to provide written informed consent exclusion criteria: * none
respiratory kinematics of cough in healthy older adults and parkinson's disease

Conditions: Cough; Parkinson's Disease

Summary: the purpose of this research study is to test cough function in individuals with parkinson's disease and healthy older adults. cough is a complex, defensive function which involves movement of the chest and lungs. the investigators want to compare the movement of the chest wall and the lungs during voluntary and reflex cough. the long-term goal of this research is to develop treatments for people with cough dysfunction. cough dysfunction increases the risk for respiratory infections such as pneumonia. the results from this study will provide information to help researchers understand the difference between reflex and voluntary cough more fully.

if the participant agrees to participate, the investigators will first test pulmonary (lung) function. next, the investigators will test voluntary and reflex cough. after this first round of cough testing, the investigators will ask participants to cough long and hard during voluntary and reflex cough testing. finally, the investigators will view the larynx (voice box) with an endoscopic camera inserted through the nose. this test is done to see if there are any changes in the larynx that may influence cough.

Eligibility criteria:
inclusion criteria: * age 55-85 years * ability to provide informed consent for participants with parkinson's disease (pd): - diagnosis of pd (hoehn \& yahr stages ii-iv) by a university of florida movement disorders fellowship trained neurologist having completed a clinical assessment of each participant's pd severity and arriving at the diagnosis of pd by applying strict united kingdom brain bank criteria. exclusion criteria: participants with pd: - history of neurological disorders other than pd (e.g. multiple sclerosis, stroke, brain tumor, etc) healthy older adults: * history of neurological disease including pd * history of head and neck cancer * history of breathing disorders or disease (i.e. chronic obstructive pulmonary disease, asthma) * history of smoking for more than 5 years at any one time (as this reduces the sensitivity to capsaicin) * history of chest infection the last 5 weeks * failure of a screening test of pulmonary function (e.g. forced expiratory volume in one second/forced vital capacity\<75%) * difficulty complying due to neuropsychological dysfunction (i.e. severe depression)

Keywords: cough reflex voluntary healthy older adults parkinson's disease respiratory kinematics cueing
health benefits of expressive writing among chinese breast cancer survivors

Conditions: Breast Cancer; Breast Neoplasms

Summary: this study is a randomized controlled trial (rct) with the aim of determining the cultural sensitivity, feasibility, and effectiveness of an expressive writing intervention for chinese breast cancer survivors.

the study examines the potential health benefits (i.e., physical health, psychological health, and quality of life) of this expressive writing intervention for chinese-speaking breast cancer survivors. the study also explores the mechanism through which expressive writing confers health benefits and investigates who will benefit most from the expressive writing intervention. chinese-speaking breast cancer survivors who have completed primary treatment will be randomly assigned to a control writing condition, a self-regulation condition, or a enhanced self-regulation writing condition. health outcomes are assessed at baseline, and 1, 3, and 6 months follow-ups. mixed qualitative-quantitative mixed methods are used to explore the effect of the intervention on health outcomes and explore the mechanisms that explain the benefits of this intervention.

Eligibility criteria:
inclusion criteria: 1) having a breast cancer diagnosis; 2) completing breast cancer surgery within five years; and 3) being comfortable writing and speaking chinese (i.e. mandarin or cantonese)

Keywords: chinese breast cancer survivors expressive writing
safety and effectiveness of ureteral dj stent with magnet (blackstar, urotech) removal under ultrasound control

Conditions: Urolithiasis

Summary: evaluation of safety and effectiveness of ureteral dj stent with magnet (blackstar, urotech), severity of stent-association symptoms and pain level syndrome after stent extraction compared with stent extraction by flexible cystoscope

inclusion criteria: * age from 18 to 70 years * males * indications for rigid or flexible urs * asa score: 1-3 exclusion criteria: * active urinary tract infection * taking alpha-1 adreno and m-cholinoblockers all patients will be randomized into 2 groups: * group a - male patients who will undergo ureteral stent placement by conventional polyurethane dj stent, fr 6.5. n=30 * group b - male patients who will undergo ureteral stent placement by polyurethane dj stent with magnet (blackstar, urotech ), fr 7. n=30 patients are to be assigned a randomization number that will match their treatment. block randomization using 10 blocks is to be performed by a central randomization organization (www.randomize.net) using a computerized algorithm. using the visual analog scale of pain (vasp) and ureteric stent symptom questionnaire (ussq) we are going to assess the pain syndrome and the severity of stent-associated symptoms. the ussq will be filled twice: 3 days after stent placement and on the day of stent removal, just before the procedure. all stents will be removed 30 days after placement. also, immediately after stent removal, patients will complete the vasp questionnaire. in the control group, the stent will be removed using flexible cystoscopy. in the experimental group under ultrasound control using a magnetic retriever, with a bladder capacity of at least 150 ml. primary assessed outcomes: 1. age 2. body mass index 3. operation side 4. the density of the stone 5. type of the operation 6. applying of the ureteral accessing sheath 7. type of the ureteral stent 8. troubles with stent placement 9. ussq (ureteral stent symptom questionnaire) 3 days after surgery 10. ussq before stent extraction 11. vasp (visual analog scale pain) immediately after stent extraction 12. duration of stent extractiom by magnetic retrieval device 13. duration of stent extraction by cystoscopy 14. stent removal success (yes/no) secondary assessed outcomes: 1. assessment of stone-free status after surgery by performing computed tomography of kidneys and urinary tract without intravenous contrasting 1 month after surgery 2. stent encrustation

Eligibility criteria:
inclusion criteria: * age from 18 to 70 years * males * indications for rigid or flexible urs * asa score: 1-3 exclusion criteria: * active urinary tract infection * taking alpha-1 adreno and m-cholinoblockers
stereotactic mri-guided radiation for localized prostate cancer

Conditions: Prostate Cancer

Summary: this single arm, prospective study will determine the prostate-specific quality of life (qol) of patients undergoing undergoing a 2 fraction mri-guided stereotactic ablative body radiation (sabr) protocol. we propose prescribing a prostate dose of 26 gy in 2 fractions and a dose of up to 32 gy to the dominant intraprostatic lesion (dil) in 2 fractions over one week.

stereotactic ablative body radiation two weekly fractions of: 13 gy to whole prostate +/- seminal vesicles and up to 16 gy simultaneous boost to dominant mri nodule treatment delivery and quality assurance treatment will be delivered on treatment units equipped with with volumetric arc therapy and hexapod couches. only photons with megavoltage energies of 6 mv will be used. cone-beam ct imaging will be performed using the implanted fiducials to set up each treatment. imaging after each fraction of radiation will be performed and the shifts in prostate positioning (as measured by displacement of gold seed fiducials) will be measured and recorded. also, the total treatment time for each fraction of radiotherapy will be recorded. patient assessments / follow-up time zero will be the start of radiotherapy. baseline and follow-up parameters are as listed in appendix a. baseline rectal and urinary function will be recorded. acute toxicities will be assessed at weeks 1, 4, and 13 and late toxicities will be assessed at month 6 and every 6 months until year 5 using the common terminology criteria adverse events, version 4.0. bloodwork (psa and testosterone), will be performed at months 3, 6 and every 6 months until year 5. qol using the expanded prostate cancer index composite (epic) will be obtained at baseline, weeks 1, 4, 13, month 6 and every 6 months until year 5.

Eligibility criteria:
inclusion criteria: 1. informed consent obtained 2. men \>18 years 3. histologically confirmed prostate adenocarcinoma (centrally reviewed) 4. favorable risk prostate cancer, defined as clinical stage t1-2c, gleason sum less than or equal to 7, and psa less than or equal to 20 ng/ml (patients can have only one of t2c, gleason sum 7 and psa 10-20 ng/ml) exclusion criteria: 1. androgen deprivation therapy (lhrh-agonists or antiandrogens) \> 6 mo 2. prior pelvic radiotherapy 3. anticoagulation medication (if unsafe to discontinue for gold seed insertion) 4. diagnosis of bleeding diathesis 5. large prostate (\>90cm3) on imaging 6. immunosuppressive medications 7. inflammatory bowel disease 8. presence of a hip prosthesis 9. contraindications to having mri
impact of knowledge and skills in management of bleeding during pregnancy

Conditions: Bleeding Management

Summary: simulation training motivates participants to interact and collaborate, and studies on interdisciplinary groups show that it improves soft skills such as communication and teamwork. midwifery students' skills are the ability to apply knowledge and use their knowledge to perform tasks and solve problems. they are cognitive in nature and include logical, intuitive and creative thinking. practical experiences such as the application of skills and methods, materials, tools and equipment further develop these skills. skills represent the application of learned abilities and the result of practical experience that emerges both cognitively and practically. in addition, feedback is included in the methods used as an important part of clinical education


Eligibility criteria:
inclusion criteria: * volunteer to participate in the research, continuing their sophomore year in the 2024-2025 spring semester, exclusion criteria: * students who do not participate in theoretical explanation
new daily persistent headache survey

Conditions: New Daily Persistent Headache (NDPH); New Daily Persistent Headache

Summary: purpose: to explore headache characteristics and treatment effects of patient with new daily persistent headache (ndph) through an online survey. research design: online survey of patients with new daily persistent headache. risks: risks include a breach of confidentiality as well as fatigue from taking the survey online. importance of knowledge that may recently be expected to result: the study aims to discover new information in a very understudied disease. this information could, in future studies, help change the diagnostic criteria or lead to new treatment options.


Eligibility criteria:
inclusion criteria: * patients with ndph that have been diagnosed by a health care professional (no documentation is needed, participant must simply state that he or she has been diagnosed) exclusion criteria: * unable to speak english (the survey is only in english) * unable to use a computer to take the online survey

Keywords: constant headache refractory headache disorder
atrial natriuretic peptide in assessing fluid status

Conditions: Fluid Overload; Fluid Loss; Volume Overload; Cardiac Disease; Cardiac Output, Low; Cardiac Output, High

Summary: biomarkers can play a significant role in fluid status assessment intraoperatively.

routinely intraoperatively the fluid status assessment is based on central venous pressure and other parameters. nevertheless, the minority of anesthesiologists use continous dynamic parameters like pulse pressure variation, stroke volume variation and other to manage fluid status. there's a fast acting biomarker that can help anesthesiologist to diagnose and manage the volemic status and possibly guide the infusion therapy better. pro-anp is a biomarker that reacts on atria strain and can be used in volemic status assessment in cardiac surgery patients.

Eligibility criteria:
inclusion criteria: cabg, one-, two valve repair/replacement, ascending aorta, aortic arch replacement, asd/avd closure, septal myectomy exclusion criteria: 1. atrial fibrillation, atrial flutter, frequent ventricular and supraventricular arrythmias 2. eflv \< 50% 3. pulmonary hypertension \> 2 st 4. ckd \> c3 (gfr \< 30) 5. redo surgery 6. left atrium volume \> 150 ml 7. lv edv \> 250 ml

Keywords: fluid responsiveness fluid status cardiac surgery volemic status pro-anp hemodynamic monitoring functional test teboul test stroke volume variation cardiac output