Kornimate/medical-research-clean huggingface dataset:
extracorporal membrane oxygenation for critically ill patients with covid-19

Conditions: COVID-19

Summary: retrospective single center analyses of covid-19 patients admitted to the icu between 01/02/2020 and 31/07/2021.

all adults (\>18 years) with acute hypoxaemic respiratory failure due to diagnosed covid-19 pneumonia and admitted to icu from 01/02/2020 until 31/07/2021 were included in the study. following the world health organisation (who) protocol 19, laboratory confirmation of covid-19 infection was defined as a positive result on polymerase chain reaction (pcr) assays of nasopharyngeal swab samples or bronchoalveolar lavage. only laboratory-confirmed patients were included in the analysis. additional data collection additional collected parameters are listed below and are collected as a standard-of-care in our hospital: * demographics: i.e age, gender, bmi * dnr code * comorbidities: smoking, obesity, hypertension, diabetes, cardiovascular disease, respiratory disease, malignancies, renal failure (aki), liver failure, gastrointestinal disease, neurological conditions, mental state, other * symptoms at the time of admission to icu: i.e fever, body temperature, dyspnoea, headache, diarrhea etc... * laboratory results of all standard parameters measured * treatment: antiviral agents, antibiotics, etc... * complications: shock, heart failure, sepsis, stroke, etc... * ventilation: method, peep, fio2, p/f ratio ..

Eligibility criteria:
inclusion criteria: * all adult covid-19 patients (\>18 years) admitted to the icu between 01/02/2020 and 31/07/2021 with a laboratory confirmation of covid-19 infection with a positive result on polymerase chain reaction (pcr) assays of nasopharyngeal swab samples or bronchoalveolar lavage exclusion criteria: * all adult patients admitted for other reasons to the icu (no covid-19 pneumonia)

Keywords: ecmo
unilateral cleft repair in one surgery with pure primary healing

Conditions: Cleft Lip and Palate

Summary: retrospective analysis of the current surgical method to repair unilateral cleft lip and palate malformations at our centre


Eligibility criteria:
inclusion criteria: * newborn patients with complete unilateral cleft lip and palate exclusion criteria: * with associated syndrome * previous lip/ palate repair * previous presurgical orthopaedics other than passive palatal plate

Keywords: cleft lip cleft palate cleft lip and palate orofacial cleft
ultrasonographic prognostic scale of periventricular hemorrhagic infarction

Conditions: Preterms; Infarction Cerebral

Summary: observational study of preterm infant with a gestational age \< 30 weeks born between 2017-2023 in neonatal care unit in gregorio marañon hospital (madrid, spain). we use a new ultrasonographic prognostic scale of periventricular hemorrhagic infarction for neurodevelopmental outcome at age 2 years.


Eligibility criteria:
inclusion criteria: * gestacional age \< 30 weeks exclusion criteria: * brain malformation * genetic syndrome * metabolic disorders * chromosomal abnormality * none cranial ultrasound
prevalence of congenital uterine malformations

Conditions: Congenital Uterine Anomalies

Summary: aims: we plan to investigate how common uterine malformations are in high-risk women (with history of miscarriage or preterm delivery), by analysing different characteristics in these groups. this study will also investigate other ultrasound characteristics detected on these women. this study will point towards the possible mechanism of how uterine malformations may affect pregnancy outcomes.

background: congenital abnormally shaped wombs (uterine malformations) have long been thought to be more common in women with poor pregnancy outcomes, e.g. miscarriage (rackow and arici 2007) and preterm delivery (tomazevic, ban-frangez et al. 2007). however, the true prevalence is difficult to assess as there are no universally agreed classification systems and some of the best investigations are invasive. in addition, previous prevalence studies have not examined the details of subfertility or pregnancy loss, such as duration of subfertility, the gestation of pregnancy loss, or miscarriage pattern. aims: we plan to investigate how common uterine malformations are in high-risk women (with history of miscarriage or preterm delivery), by analysing different characteristics in these groups. this study will also investigate other ultrasound characteristics detected on these women. this study will point towards the possible mechanism of how uterine malformations may affect pregnancy outcomes. methods: we plan to recruit women who have had miscarriage or preterm delivery into our study. a sample of women who had normal term deliveries will be recruited as comparison. all women will undergo one 3-dimensional ultrasound scan each. outcomes: the proportions of women with congenital uterine malformations will be determined. any ultrasound-detected markers found especially in women with poor pregnancy outcomes may point towards how uterine malformations affect pregnancies.

Eligibility criteria:
inclusion criteria: 1. women with a previous miscarriage * age: 18 years old or more * definition of miscarriage: the spontaneous pregnancy loss up until 24 weeks of gestation, where the pregnancy was confirmed histologically or with previous presence of a gestational sac with or without fetal pole and fetal heart activity on ultrasound scanning. * at least 8 weeks after the end of last pregnancy 2. women with preterm birth * age: 18 years old or more * definition of preterm birth: birth at less than 37 weeks of gestation. * at least 8 weeks after the end of last pregnancy 3. control group (women with term birth) * age: 18 years old or more * definition of term birth: birth at 37 or more weeks of gestation * at least 8 weeks after the end of last pregnancy exclusion criteria: * pregnant at the date of the 3d tvus * recent uterine or endometrial surgery * women unable to tolerate 3d tvus * unable to give informed consent

Keywords: mullerian anomalies congenital uterine malformations or anomalies arcuate septate subseptate bicornuate unicornuate didelphys t-shaped
relationship between oral lichen planus and autoimmune thyroid diseases

Conditions: Oral Lichen Planus

Summary: on the basis of previous studies, a validation cohort will be established to explore the relationship between oral lichen planus and autoimmune thyroid diseases, and a disease efficacy prediction strategy can be formed.

for oral lichen planus patients, the prevalence of hashimoto's thyroiditis will be investigated and the relationship between levels of anti-tg, anti-tpo antibodies and severity of oral lichen planus will be determined. besides, for patients with hashimoto's thyroiditis, the prevalence of oral lichen planus will be investigated and the relationship between levels of anti-tg, anti-tpo antibodies and severity of oral lichen planus will be determined.

Eligibility criteria:
inclusion criteria: * olp patients without systemic disease exclusion criteria: * olp patients with severe periodontal disease
magnesium and intraoperative blood loss in meningioma surgery

Conditions: Meningioma

Summary: meningioma is the most common central nervous system tumor and craniotomy with tumor removal was associated with moderate blood loss and blood transfusion. magnesium has hypotensive effect and probably reduce intraoperative blood loss. whether or not magnesium sulphate can reduce intraoperative blood loss and improve postoperative cognitive function is still inconclusive. so the investigators conduct the randomized control trial to compare the effect of magnesium with placebo control in blood loss and cognitive function in meningioma patient undergoing craniotomy.

the investigators enroll 120 patient who admitted for craniotomy for meningioma removal. then, the patients will be divided into two groups. the first group or group mg will receive magnesium sulphate 40 mg/kg infuse for 30 min (started at skin incision), and then infuse magnesium sulphate 10 mg/kg/hr until the dura will be closed. the another group or normal saline group will receive the same amount of 0.9% sodium chloride. the anesthesia and surgery are standardized. the recorded data include patient demographic data, intraoperative blood loss, hemodynamics and pre and postoperative montreal cognitive assessment score.

Eligibility criteria:
inclusion criteria: * meningioma patient * schedule for supratentorial craniotomy with tumor removal * american society of anesthesiologists physical status 1-3 * age 18-70 years * no alteration of conscious (full glasgow coma score) and well cooperate * expected to extubation after operation exclusion criteria: * unstable hemodynamic (severe hypotension or hypertension who receive antihypertensive and vasopressor before surgery but not include baseline oral antihypertensive drug) * known cardiac disease from either history, physical examination or investigation * patient who have heart block * hepatic disease (child pugh score class c) * renal insufficiency (egfr \< 60 ml/min from chronic kidney disease epidemiology collaboration equation) * allergy to magnesium or other drugs use in the study * patient who receive calcium channel blocker drug * pregnancy * patient who receive magnesium for treatment such as arrhythmia or preeclampsia * hypermagnesemia (more than 2.6 mg/dl) before surgery * bmi more than 30 kg/m2 * patient who probably have brain herniation from increase intracranial pressure

Keywords: meningioma magnesium montreal cognitive assessment blood loss controlled hypotension blood transfusion neuroprotective anesthesia
lung ultrasonography decreases radiation exposure

Conditions: Newborn Rds; Transient Tachypnea of the Newborn; Pneumonia

Summary: we aimed to decrease in the number of chest x-rays in newborns with respiratory distress, with the use of lung ultrasonography. from january 2019 to june 2020, 104 newborn infants with respiratory distress enrolled in this study. we used bed side ultrasound as the first line tecnique for lung imaging. x-ray were taken in cases with increasing respiratory distress in spite of treatment according to diagnosis depending on usg findings. we calculated decreased number of chest x-ray for every patient and evaluated the estimated decrease in radiation exposure.

background: chest x-ray is commonly used as first line imaging method to diagnose the reason of respiratory distress in nicus. lung ultrasound is a new diagnostic tool for lung imaging, and this method has been used more common recently in nicus. objectives: we aimed to determine the decrease in the number of chest x-rays in newborns with respiratory distress, with the use of lung ultrasonography. methods: from january 2019 to june 2020, 104 newborn infants with respiratory distress enrolled in this study. we used bed side ultrasound as the first line tecnique for lung imaging. x-ray were taken in cases with increasing respiratory distress in spite of treatment according to diagnosis depending on usg findings. we calculated decreased number of chest x-ray for every patient and evaluated the estimated decrease in radiation exposure.

Eligibility criteria:
inclusion criteria: * term or preterm neonates with respiratory distress that started within the first 24 h after birth were included if they showed at admission signs of respiratory distress defined as: tachypnea (respiratory rate \>60 breaths/min), intercostal/subcostal retractions, grunting, or fio2 requirement \>0.21. exclusion criteria: * patients with a diagnosis of major malformations or chromosomal abnormalities, inherited metabolic diseases, congenital muscle disease-hypotonicity, hypoxic ischemic encephalopathy were not enrolled.

Keywords: lung ultrasonography chest x ray newborn
impact of social support and coping strategies on post-surgical pain

Conditions: Social Support; Coping Behavior; Post-Surgical Pain, Chronic

Summary: the purpose of the study is to evaluate the impact of social support and pain coping strategies in the development and evolution of post-surgical pain.

this is a longitudinal study. after giving their informed consent, patients will answer online questionnaires assessing pain and different psychosocial variables at these time points: before surgery, one to three days after surgery, and one, three, and six months after surgery. the psychosocial variables evaluated are the following ones : * depression, * anxiety, * stress, * pain coping strategies, * social support, * couple support.

Eligibility criteria:
inclusion criteria: * aged over 18 years of age. * capacity to understand and voluntarily sign an informed consent form in french. exclusion criteria: * insufficient french language skills. * history of psychotic disease. * history of neurodegenerative pathology. * history of neurological disease (e.g. stroke) * pre-existing pain condition related to the reason for surgery

Keywords: pain, chronic
amino acid supplementation in continuous renal replacement therapy

Conditions: Acute Kidney Injury

Summary: icu patients treated with continuous renal replacement therapy is recruited prior to start of treatment. blood samples are drawn and then dialysis start without amino acid supplementation. after a few hours samples are drawn from blood and dialysate. then patients are given amino acid supplementation (33.5g/24hrs) for 20-24 hours. new samples are drawn and amino acid supplementation is increased to 67g/24hrs and new samples are drawn after additional 24 hours. then crrt will continue with the full amino acid supplementation (standars of care).


Eligibility criteria:
inclusion criteria: * dialysis where amino acid supplementation is planned by treating physician exclusion criteria: * liver failure * muscle disease * neurodegenerative disease
an exploratory study of potential sources of efficacy dilution in the voice trial (mtn-003)

Conditions: HIV Prevention

Summary: this study is primarily exploratory and is designed to both identify factors that may have affected participant adherence to study product in voice, and describe how sexual behaviors, such as anal sex, may have had an effect on product efficacy. as such there is no specific hypothesis that is being tested.

mtn-003d will use qualitative in-depth interviews and/or focus group discussions with voice participants to explore study product adherence and/or anal sex behaviors in greater depth than was measured quantitatively during trial participation. the study approach is designed to encourage honesty and to minimize socially desirable responses, which may have affected participants' ability/willingness to accurately report during the trial. an in-depth and candid understanding of the various behavioral factors that contribute to the dilution of efficacy may assist in the interpretation of voice trial results and inform future studies. in light of voice's divergent results, mtn-003d will explore the potential factors that may have contributed to efficacy dilution in the trial. mtn-003d, was initially designed after the early closure of the oral and vaginal tenofovir arms, and sought to explore those factors contributing to the dilution of efficacy using qualitative methods (stage 1). given the subsequent release of voice results in february of 2013 and the availability of drug pk data, stage 2 of mtn-003d has been designed to explore factors influencing adherence in greater depth, including hiv risk perception and motivation to join the trial.

Eligibility criteria:
inclusion criteria: * able and willing to perform the study procedures * able and willing to provide informed consent in one of the mtn-003d study languages * participated in voice and received at least three consecutive months of study product at any time during voice trial participation * stage 2 participants must have pharmacokinetic data available note: women from stage 1 who have pk data available will be considered eligible for stage 2 exclusion criteria: * has any condition that, in the opinion of the investigator or record(ior)/ designee: * would preclude informed consent * make study participation unsafe * complicate interpretation of study outcome data * otherwise interfere with achieving the study objectives.
tolerability and efficacy of l-serine in patients with amyotrophic lateral sclerosis (als)

Conditions: Amyotrophic Lateral Sclerosis (ALS)

Summary: the purpose of this study is to determine the tolerability of l-serine oral doses for als patients and assess preliminary indications of efficacy

all patients will receive the same dose of the study treatment over 6 months. for each participant the study will last approximately one year with follow up visits after the treatment period of 6 months is completed. the visits will include blood draws, vital sign checks, neurological and physical exams, pulmonary testing with forced vital capacity (fvc), and questionnaires.

Eligibility criteria:
inclusion criteria: * diagnosis of probable or definite als * alsfrs-r score \>25 and fvc score ≥ 60% predicted * if currently taking riluzole and/or edaravone/radicava must be on stable dose for 3 months prior to baseline/screening. if the dosing has not been stable for 3 months prior to baseline/screening or if stopped due to an adverse event, the waiting period off the medication will be 7 days. if not on either of these medications may start if desired either or both medications after enrollment into study. exclusion criteria: * diagnosis of probable or definite als more than 3 years prior to study enrollment * diagnosis or previous history of ischemic stroke, brain tumor, uncontrolled diabetes, renal insufficiency, or severe hypertension. * diagnosis or previous history of comorbid progressive neurodegenerative disease such as alzheimer's disease, parkinson's disease, lewy body disease, pick's disease, huntington's disease, progressive supranuclear palsy. als patients diagnosed with frontotemporal dementia will not be excluded from this study. * diagnosis or previous history of symptomatic peripheral neuropathy. patients with findings of peripheral neuropathy on electrodiagnostic tests only but no clinical symptoms at the time of enrollment are eligible. * undergoing any chemotherapy or radiation therapy for any cancer * any medical condition likely to interfere with the conduct of the trial or survival of the patient during this study period * pregnant women or women who are breast feeding * has taken l-serine supplement within 30 days prior to start of study drug
localising occult prostate cancer metastases with advanced imaging techniques

Conditions: Prostate Cancer

Summary: the investigator prospectively compare diagnostic concordance of whole body multi---parametric magnetic resonance imaging (mri) with current conventional multi---modality reference standard imaging (ct scan, isotope bone scan +/--- pet---ct scan) for staging of prostate cancer patients with biochemical relapse following external beam radiotherapy or brachytherapy of locally advanced prostate cancer.

the investigators have developed and assessed the feasibility of performing whole---body multi---parametric mri for staging metastatic disease. the investigators hypothesize that a whole body multi---parametric mri will be more sensitive and specific than conventional imaging staging for detection of metastatic disease in patients with biochemical failure following local therapies. investigators therefore propose a comparative trial of conventional imaging verses whole---body multi---parametric mri within this population of men. the investigators would further like to explore whether heterogeneity between metastases of multi---parametric mri signals can predict men unlikely to respond to adt. the investigators aim to enhance the main study by exploratory work on exosome, pathway and genomic analysis, the results of which could lead to complimentary imaging / non---imaging biomarker combinations of clinical utility for patient stratification. finally the investigators will perform a health economic analysis to assess the cost---effectiveness of whole---body multi---parametric mri for metastatic disease staging compared with conventional staging with computed tomography and bone---scans.

Eligibility criteria:
inclusion criteria: * men who have undergone previous external beam radiotherapy or brachytherapy with or without neo---adjuvant/adjuvant hormone therapy * men who have radiorecurrent disease defined by biochemical failure - phoenix definition (psa nadir + 2 ng/ml) exclusion criteria: * men unable to have mri scan, or in whom artefact would significantly reduce quality of mri * men unable to give informed consent
comparison of caries arrested & prevented among sdf, naf varnish and combination in children

Conditions: Dental Caries in Children; Satisfaction; Cost Effectiveness; Oral Health; Quality of Life

Summary: tooth decay is one of the most common chronic infectious disease found in children worldwide and if left untreated, is rapidly progress. severe tooth decay in children is not only affect child's health and school performance, but also has impact on the family well-being. oral rehabilitation in children requires time, resources and effort of dental specialists, the child and parents. caries is a destructive condition of organic and inorganic components of the tooth structures but reversible and most importantly, preventable. topical fluoride therapy, delivered by dentists has been effectively used to speed up the repair process as well as to strengthen the surface of intact tooth structure. topical fluoride is available in various preparations. regular application of sodium fluoride varnish is every three months, by far, considered as effective method in preventing new caries, particularly in the high-risk children. it has the advantage of containing therapeutic concentration of fluoride and ability to flow over and stick to the tooth surface. whereas silver ion and relatively higher fluoride concentration in silver diamine fluoride (sdf) has been shown to be the most effective in harden the decay, stop the caries progress and eliminate pathogenic bacteria. it can be hypothesize that when use in combination in school children, both reagents might have synergistic effect on arresting existing caries as well as preventing new caries.

fluoride varnish is a good choice to consider. for caries prevention in young children, it has high efficacy in caries prevention. fluoride varnish has a high f concentration and prolong contact time with enamel, so it can prevent new caries and remineralize initial enamel caries. silver diamine fluoride solution is effective in arresting dentine caries. silver diamine fluoride has high fluoride concentration and contain silver ion. when apply dentine caries or cavitated caries can increase hardness of dentine and arresting caries. when use in combination, it might enhance, the efficacy in arresting and preventing dental caries in children

Eligibility criteria:
inclusion criteria: * school children aged 6- 7 years old. * have at least one or more active dentin caries lesions in primary canine/molar. * parents give consent. exclusion criteria: * uncooperative child * allergic reaction to silver or materials containing adhesive. * received topical fluoride 3 months prior to enrollment. * primary carers are unable to response to questionnaire.

Keywords: silver diamine fluoride sodium fluoride varnish arrest caries caries prevention cost effectiveness oral health quality of life