Kornimate/medical-research-clean huggingface dataset:
low-dose buprenorphine initiation for opioid use disorder

Conditions: Opioid Use Disorder

Summary: the purpose of this study is to test whether low-dose buprenorphine initiation for treatment of opioid use disorder is safe and effective.

after being informed about the study and potential risks, all participants will be given written informed consent. eligible participants will be randomized in a 1:1 ratio to an 8-day low-dose buprenorphine initiation protocol or treatment as usual, and conduct study visits at baseline and weeks 2 and 4. the investigators will also provide participants with mobile phones to collect real-time data on withdrawal, anxiety, craving and substance use through electronic ecological momentary assessment (ema) technology.

Eligibility criteria:
inclusion criteria: 1. provision of signed and dated informed consent form 2. stated willingness to comply with all study procedures and availability for the duration of the study 3. any gender, aged 18 years or greater 4. opioid use disorder (based on diagnostic and statistical manual- version 5 criteria) 5. ability to take sublingual medication 6. willingness to adhere to the assigned buprenorphine initiation regimen 7. fluency in english or spanish 8. for participants of reproductive potential: agreement to use highly effective contraception during study participation exclusion criteria: 1. use of fda-approved medications for opioid use disorder treatment (within 7 days prior to screening), including methadone, buprenorphine, or naltrexone 2. diagnosis of alcohol use disorder, severe or benzodiazepine use disorder, severe (based on diagnostic and statistical manual- version 5 criteria) 3. severe untreated mental illness, meaning psychosis or suicidality 4. presence of an acute or chronic medical condition that would make participation medically hazardous 5. pregnancy or lactation 6. known allergic reactions to buprenorphine or naloxone 7. inability to consent due to cognitive impairment

Keywords: opioid use disorder micro-induction microdosing low-dose initiation buprenorphine micro-initiation
effect of synbiotic as an adjuvant therapy in the treatment of parkinson's disease

Conditions: Parkinson's Disease

Summary: this study aims to investigate the possible efficacy and safety of synbiotic preparation of lactobacillus acidophilus probiotic with prebiotic fibers as an adjuvant therapy in the treatment of parkinson's disease


Eligibility criteria:
inclusion criteria: * age between 45 and 65 years old * both sexes * patients with parkinson's disease on dopamine replacement therapy * modified hoehn and yahr stage, mhy 1-4 exclusion criteria: * patients who are currently using or used antibiotics therapy in the preceding month * patients who are currently using or used other probiotic products in the preceding two weeks * patients scheduled to undergo git surgery or those underwent git surgery * patients with known allergy to probiotics * patients receiving artificial enteral or intravenous nutrition * patients with depression and/or psychosis * patients taking antioxidant and/or anti-inflammatory medications * patients with hyperthyroidism * patients with inflammatory condition and/or condition involving oxidative stress * smokers * modified hoehn \& yahr stage mhy 5
pilot study on proteomics of erythrocyte proteins in patients with copd based on tmt technology

Conditions: Protein; Disease

Summary: chronic obstructive pulmonary disease (copd), a common and complex disease characterized by persistent airflow limitation, is a leading cause of mortality worldwide. copd and its comorbidity are associated with hypoxia condition. further investigations on the cellular and molecular aspects of hypoxia in copd should help to reveal the mechanisms underlying the development of this disease. dysfunction of the erythrocyte, a main medium to transport oxygen through the blood, contributes to the prognosis and severity of copd through hypoxia. it is proposed that dysregulated proteins in erythrocytes that impair oxygen transport may be involved in the development of copd. however, a comprehensive study on altered proteins of erythrocytes in copd is still lacking. proteomics techniques and protein chip techniques provide a high throughput screening method to figure out characteristic inflammatory or metabolic markers of diseases. therefore, this study is to evaluate the clinical significance of differential erythrocyte proteins in the course of copd disease.


Eligibility criteria:
1. case group inclusion criteria: 1. age from 40 to 80 years old; gender is not limited. 2. stable copd 3. sign the informed consent with the willingness of obeying the protocol. - exclusion criteria: 1. subjects with known other chronic respiratory diseases except for copd (such as asthma, tuberculosis, bronchiectasis, interstitial lung disease, occupational lung diseases, sarcoidosis, lung cancer, et al); 2. subjects had been accepted lung lobectomy or transplantation; 3. subjects be ill with severe, or uncontrolled systemic diseases other than copd (such as psychiatry diseases, chronic liver diseases, heart failure, auto-immunity diseases, chronic renal diseases, et al ); 4. alcoholism, drug or solvents addition; 5. acute exacerbation copd patients (aecopd) - 2. control group inclusion criteria 1. age from 40 to 80 years old; gender is not limited. 2. sign the informed consent with the willingness of obeying the protocol. - exclusion criteria 1. subjects with known other chronic respiratory diseases (such as copd, asthma, tuberculosis, bronchiectasis, interstitial lung disease, occupational lung diseases, sarcoidosis, lung cancer, et al); 2. subjects had been accepted lung lobectomy or transplantation; 3. subjects be ill with severe, or uncontrolled systemic diseases other than copd (such as psychiatry diseases, chronic liver diseases, heart failure, auto-immunity diseases, chronic renal diseases, et al ); 4. alcoholism, drug or solvents addition;

Keywords: copd erythrocyte proteomics
long-term study of duodopa (levodopa/carbidopa) in advanced parkinson's: health outcomes & net economic impact

Conditions: Advanced Idiopathic Parkinson's Disease

Summary: the primary objective of this study is to collect health economic data depicting the initial levels and natural progression over time of resource usage, parkinson's disease (pd)-related costs, and health related quality of life (hrqol) for a cohort of advanced pd patients treated with duodopa (levodopa-carbidopa in an intestinal gel formulation), of which about one-third were duodopa-naïve prior to the start of the study.


Eligibility criteria:
inclusion criteria: - advanced idiopathic parkinson's disease exclusion criteria: - other diseases which might influence compliance or participation in the study

Keywords: health economics,quality of life
impact of personalized feedback alone on substance use behaviors

Conditions: Substance Abuse

Summary: the investigators seek to develop a more efficient and effective approach to providing brief behavioral health interventions for risky substance use behaviors by comparing a brief coach directed intervention to a tailored report only group.

screening and brief intervention (sbirt) generally involves universal screening for risky substance use behaviors in medical settings and the immediate provision of a 3-15 minute intervention to those found to be at risk. in this pilot study, the investigators seek to develop a more efficient and effective approach to providing brief behavioral health interventions in the field by comparing a brief coach directed intervention to a tailored report only group. the goal is to create a cost-effective and sustainable system that provides consumers with tailored information that will help them both initiate and sustain the lifestyle changes necessary for improving their overall health. hypothesis 1: in a medical setting, personalized feedback alone will be associated with a reduction in risky substance use behaviors. hypothesis 2: in a medical setting, personalized feedback alone will have the same impact on behavior as that information plus a brief coach education session on risky substance use behaviors..

Eligibility criteria:
inclusion criteria: * low level risky substance use exclusion criteria: * high substance use risk levels * potential alcohol or drug addiction or dependence

Keywords: sbirt brief intervention alcohol drug abuse
a real-world evidence study in china of the catalys precision laser system

Conditions: Cataract

Summary: this study is a prospective, single-arm, observational study of the catalys precision laser system in real-world clinical practice. the study will be conducted at one site at the boao super hospital in lecheng international medical tourism pilot zone of hainan province in china. the study is being conducted to evaluate the overall performance of the catalys precision laser system. one or both eyes of each subject will be included in study. the catalys system is used as part of cataract surgery to create laser cuts as intended by the surgeon to aid in cataract surgery, without adversely impacting the risk to the patient.as such, the endpoints of surgeon rating of completeness of corneal incisions, anterior capsulotomy and phacofragmentation and any device related adverse events from the time of catalys system use to 1-month postoperative follow-up should adequately cover the evaluation of the intended use of the catalys system.


Eligibility criteria:
inclusion criteria all criteria apply to each study eye: note: study inclusion and exclusion criteria will be per the catalys system instructions for use. a few key criteria are listed below: * patients scheduled for cataract surgery, including treatment with the catalys precision laser system for anterior capsulotomy, phacofragmentation and the creation of single plane and multi-plane arc cuts/incisions in the cornea. * signed informed consent and privacy protection authorization or equivalent documentation necessary to comply with applicable privacy laws pertaining to medical treatment and/or medical record in the governing countries * at least 22 years of age at the time of consent.ion criteria exclusion criteria: all criteria apply to each study eye: * presence of corneal ring and/or inlay implant(s), descemetocele with impending corneal rupture) * severe corneal opacities, corneal abnormalities, significant corneal edema, or diminished aqueous clarity that obscures oct imaging of the anterior lens capsule. * any contraindications to cataract surgery
impact of pelvic joint stiffness on the fear of falling in subjects aged over 75 years

Conditions: Fear of Falling; Pelvic Joint/Ligament Damage

Summary: the pelvic girdle is the mechanical structure at the center of the balance and walking systems. the lack of amplitude of the joints that compose it could induce a fear of falling, common in the geriatric population and often underdiagnosed with poorly identified risk factors. this study seeks to highlight an association between fear of falling and lack of amplitude of the different joints of the pelvic girdle in order to identify predisposed patients and to set up preventive measures and better medical care.

the pelvic girdle is the mechanical structure at the center of the balance and walking systems. the lack of amplitude of the joints that compose it could induce a fear of falling, common in the geriatric population and often underdiagnosed with poorly identified risk factors. fear of falling is defined as the enduring preoccupation with falling, leading the person to avoid activities that they are capable of doing. it modifies its behavior and affects its quality of life, its well-being and increases the risk of developing pathologies linked to the lack of physical activities. joint stiffness is a major disorder in the elderly linked to bone and joint aging, but also to lack of mobilization. the pelvic girdle is the mechanical structure at the center of the balance and gait systems. the lack of amplitude of the joints that compose it could induce a fear of falling. this study seeks to highlight whether there is an association between the fear of falling and the lack of amplitude of the different joints of the pelvic girdle.

Eligibility criteria:
inclusion criteria: * subjects aged over 75 years hospitalized or in institution in the geriatric department of ghsif (groupe hospitalier sud -ile-de france) exclusion criteria: * patients that have undergone a lumbar surgery * patients with hospital diagnosed cognitive troubles

Keywords: pelvic joint; fear of falling ankylosis
use of tamsulosin to reduce the incidence and duration of postoperative urinary retention following spine surgery

Conditions: Postoperative Urinary Retention

Summary: postoperative urinary retention is a frequent complication of spinal surgeries and impacts a large portion of this population which results in increased morbidity as a result of increased number of catheterizations, urinary tract infections (utis) and prolonged hospital stays. with the addition of tamsulosin, the investigators would anticipate a reduction in the incidence and duration of postoperative urinary retention and therefore a reduction in morbidity related to treatment of urinary retention as well as shortened hospital stays.

decompressive laminectomy and spinal fusion procedures are among the most common neurosurgical procedures performed. postoperative urinary retention (pour) is a frequent complication of such surgeries and impacts a large proportion of this population resulting in multiple intermittent bladder catheterizations for bladder decompression, increased incidence of bacteremia, increased incidence of utis, and prolonged hospital stays. use of a uroselective alpha-1-adrenergic receptor antagonist, such as tamsulosin, in the perioperative period (medication started five days prior to surgery and taken until hospital discharge) could reduce both the incidence and duration of postoperative urinary retention, resulting in shorter hospital stays and decreased healthcare costs.

Eligibility criteria:
inclusion criteria * ≥ 35 years (males \& females) * cervical laminectomy * cervical posterior fusion * cervical anterior/posterior fusion * lumbar laminectomy * lumbar posterolateral fusion * lumbar interbody fusion exclusion criteria * \< 35 years * cervical anterior discectomy and fusion * cervical anterior corpectomy * cervical posterior discectomy * cervical foraminotomy * lumbar discectomy (metrx or open) * lumbar foraminotomy * lumbar anterior fusion * myelopathy with bladder dysfunction * patients currently taking an alpha-antagonist * patients with history of allergy or sensitivity to tamsulosin or other alpha-antagonist (alfuzosin, doxazosin, prazosin, terazosin, tamsulosin, and phenoxybenzamine) * history of prostatectomy or urologic surgery involving the bladder or urethra * severe liver disease or end-stage renal disease * patients taking strong inhibitors of cyp3a4 (ketoconazole, itraconazole, clarithromycin, ritonavir, indinavir/ritonavir, lopinavir/ritonavir, and conivaptan) * patients with a mental disability * prisoners
dahanca 25a: resistance training and dietary supplements as intervention for regaining muscle mass following radiotherapy in head and neck cancer patients

Conditions: Head and Neck Neoplasms

Summary: the purpose of this study is to investigate whether resistance training in combination with dietary supplementation is tolerable among head and neck cancer patients and to evaluate the possible effect on muscle mass, strength and functional capacity.

head and neck cancer patients experience a significant loss of muscle mass following radiotherapy treatment due to cachexia and dysphagia. this negatively affects muscle strength and functional capacity. studies on healthy individuals and various groups of patients show that resistance training in combination with protein and creatine ingestion is an effective means of increasing muscle mass, strength and functional capacity. thus the aim is to investigate the following: * is resistance training and dietary supplements tolerable among head and neck cancer patients * the effect of the intervention on muscle mass, strength and functional capacity

Eligibility criteria:
inclusion criteria: * head and neck cancer patients (localized to the larynx, pharynx and oral cavity) treated with curative radiotherapy * complete loss of tumor * who performance status between 0-1 and expected ability to complete the training protocol * no parenteral feeding * above the age of 18 * written concent exclusion criteria: * other malignant diseases * pregnancy * undergoing systematic resistance training or creatin ingestion * alcohol abuse

Keywords: head and neck neoplasms resistance training muscle mass functional capacity
a study of soticlestat in healthy adult nondependent recreational drug users with central nervous system (cns) depressant experience

Conditions: Healthy Volunteers

Summary: the main aim is to evaluate the relative abuse potential of soticlestat in healthy adults who has used central nervous system (cns) depressants for recreational nontherapeutic reasons.

the drug being tested in this study is called soticlestat. soticlestat is being tested in healthy participants. this study will assess the relative abuse potential of soticlestat compared to alprazolam and placebo in healthy adult, nondependent recreational drug users with cns depressant experience. the study will enroll approximately 110 participants. participants will be randomly (by chance, like flipping a coin) assigned to treatments of the study. treatment order will remain undisclosed to the participants and study doctor (unless there is an urgent medical need). this single center trial will be conducted in the united states. participants will be followed up for up to 7 days after the last dose of study drug for a follow-up assessment. the overall time to participate in this study is approximately 11 weeks.

Eligibility criteria:
inclusion criteria 1. healthy as determined by the investigator. 2. current cns depressant user who has used cns depressants (example, benzodiazepines, barbiturates, zolpidem, eszopiclone, zopiclone, propofol/fospropofol, gamma-hydroxybutyrate) for recreational, nontherapeutic reasons at least 10 times in their lifetime and at least once in the 12 weeks prior to screening. participant must also have recreational experience with at least 1 other drug class associated with abuse (example, opioids, stimulants, cannabinoids, hallucinogens, dissociatives) at least 10 times in their lifetime. 3. body mass index (bmi) of 18.5 to 35.0 kilogram per square meter (kg/m\^2), inclusive, and a minimum body weight of 50.0 kilogram (kg) at screening. exclusion criteria 1. self-reported history of drug or alcohol dependence (within the past 1 year, except caffeine or nicotine, prior to the screening visit). 2. positive alcohol breathalyzer or urine drug screen (uds) for substances of abuse at admission, excluding tetrahydrocannabinol (thc). 3. heavy smoker or user of other types of nicotine products (greater than \[\>\] 20 cigarettes equivalent per day). 4. unable to abstain from smoking for at least 2 hours before and at least 8 hours after dosing. 5. consumes excessive amounts, defined as greater than 4 servings (1 serving is approximately equivalent to 120 mg of caffeine) of coffee, tea, cola, energy drinks, or other caffeinated beverages per day.

Keywords: drug therapy
epssg (european soft tissue sarcoma study group) protocol for non-metastatic rhabdomyosarcoma in children

Conditions: Rhabdomyosarcoma

Summary: the purpose of the study is achieve standardization treatment of low and intermediate risk rhabdomyosarcoma patients, with an attempt to improve treatment results in high and very high risk patients by the addition of doxorubicin as induction treatment and at the maintenance phase.


Eligibility criteria:
inclusion criteria: * child * non metastatic rhabdomyosarcoma * adequate heart, kidney, liver function exclusion criteria: * age over 21 years, under 6 months * metastatic disease * heart, kidney, liver disease
measurements of lower limbs and spine based on biplanar radiographs: microdose compared to standard dose protocol

Conditions: Underdevelopment; Congenital Malformation, Lower Limb; Scoliosis

Summary: evaluation of accuracy and reliability of 2d and 3d measurements of the spine and lower limbs in adults based on biplanar radiographs with microdose protocol compared to a standard dose protocol

evaluation of accuracy and reliability of 2d and 3d measurements of the spine and lower limbs in adults based on biplanar radiographs with microdose protocol compared to a standard dose protocol part 1: retrospective evaluation of 50 patients: lower limb images with microdose protocol and lower limb images with standard dose protocol part 2: prospective evaluation of 100 patients: lower limb images with microdose protocol and lower limb images with standard dose protocol part 3: prospective evaluation of 150 patients: spine images with microdose protocol and spine limb images with standard dose protocol

Eligibility criteria:
inclusion criteria: * inclusion: all patients referred for biplanar radiographs of spine and lower limb (from 18 to 99 years of age) exclusion criteria: * exclusion criteria: no informed consent
dose escalation study using ultra-hypofractionated, image-guided, intensity-modulated radiotherapy in prostate cancer

Conditions: Prostate Cancer; Adenocarcinoma

Summary: the purpose of this study is to test the safety of a new type of ig-imrt called "ultra-hypofractionated ig-imrt" where a higher dose of radiation is given to the tumor during each treatment day. since higher doses of radiation are used each day, the total number of treatment days needed to complete this type of radiation is only five instead of the 45-48 treatments currently used. treatment takes place every other day and is complete after 2 weeks. if the patient decides to get this treatment, they will come in for 5 treatments. this is different from the 48 treatments they would get normally.


Eligibility criteria:
inclusion criteria: eligibility is not restricted to mskcc to confirm biopsy/diagnosis. participating institution testing is sufficient. * low and intermediate risk prostate cancer patients will be eligible for this study. risk groups will be assigned as per nccn guidelines. * low risk patients will be defined as: * psa \< or = to 10 ng/ml and * gleason score = 6 and * clinical stage \< or = to t2a * intermediate risk patients will be defined as: * psa 10-20 ng/ml or * gleason score = 7 or * clinical stage t2b/t2c additionally, patients will be required to meet the following criteria: * age \> or = to 18 * kps \> or = to 70 * pre-treatment endorectal coil mri or ct (mri preferred) at mskcc showing no definite evidence of radiographic t3, t4, or n1 disease * prostate size \< or = to 60 cc * international prostate symptom score \< or = to 15 exclusion criteria: * prior androgen deprivation therapy for prostate cancer * elective pelvic lymph node irradiation * kps \< 70 * pelvic mri or ct (mri preferred) evidence of radiographic t3, t4 or n1 disease * presence of distant metastasis as determined by: o alkaline phosphatase \> or = to uln or * whole body bone scan positive for osseous metastases * prior history of transurethral resection of the prostate * prior history of chronic prostatitis * prior history of urethral stricture * prior history of pelvic irradiation * history of inflammatory bowel disease * unable to give informed consent * unable to complete quality of life questionnaires abnormal complete blood count. any of the following * platelet count less than 75,000/ml * hb level less than 10 gm/dl * wbc less than 3.5/ml * abnormal renal function tests (creatinine \> 1.5)

Keywords: prostate radiation 09-035