Kornimate/medical-research-clean huggingface dataset:
exercise-induced cardiac adaptions in rheumatoid arthritis patients during il-6 vs. tnf antibody therapy

Conditions: Rheumatoid Arthritis

Summary: the present study will investigative the physiological effects of the cytokines interleukin-6 (il-6) and tumor necrosis factor (tnf) on the adaptive changes to exercise in patients with rheumatoid arthritis. the investigators hypothesize that blockage of il-6 receptors will decrease the cardiac and metabolic adaptations to exercise training compared to the inhibition of tnf. 80 patients will be included in a 12-week investigator blinded randomised exercise training intervention study.

80 patients with rheumatoid arthritis who are being treated with either interleukin-6 receptor blockers (il-6rb) or tumor necrosis factor inhibitors (tnfi) for a minimum of four months prior to enrollment will be recruited and undergo baseline testing, including examination, biochemistry, ecg, dxa, ogtt, pulmonary function, vo2max, echocardiography, cardiac mri. after baseline testing, 40 patients in il-6 receptor blocker treatment and 40 patients in tnf inhibitor treatment.will be randomly allocated into one group receiving standard of care (control group) or a group performing supervised high-intensity interval training three times a week over a period of 12 weeks. the randomization procedure involves a computer-generated block randomization schedule in a ratio of 1:1 stratified by sex by an independent person. following the 12-week intervention period, all groups will complete a series of follow-up tests (as baseline testing).

Eligibility criteria:
inclusion criteria: * age \>= 18 and \<70 years * informed consent * diagnosed ra based on the 2010 american college of rheumatology/ eular criteria. in biological treatment with either il-6rb og tnfi over four months prior to enrollment * low ra disease activity, based on the disease activity score-28 esr for rheumatoid arthritis (das28) \<=3.2 * an electrocardiogram without features of left ventricular hypertrophy defined by the european society of cardiology * females of childbearing potential have to use one or more of the following highly effective methods for contraception in order to be included: * vasectomized partner * bilateral tubal occlusion * sexual abstinence * intrauterine device * hormonal contraception * females who are considered to have no childbearing potential are * bilateral tubal ligation * bilateral oophorectomy * complete hysterectomy * postmenopausal defined as 12 months with no menses without an alternative medical cause exclusion criteria: * health conditions that prevent participating in the exercise intervention determined by the project coordinator * subjects who cannot undergo mri scans (metallic implants or claustrophobia) * corticosteroid use per os \> 10 mg/day within seven days of study enrollment * intramuscular corticosteroid within 3 weeks of the study enrollment * grade 2 hypertension (systolic bp \> 160 mmhg and/or diastolic bp \>100 mmhg) despite the use of antihypertensive drugs. * pregnancy * subjects with insulin dependent diabetes

Keywords: cardiac adaptations metabolic adaptations high intensity interval training
evaluation of fibromyalgia with disease activity and clinical findings in women with behçet's disease

Conditions: Behcet's Disease; Fibromyalgia

Summary: in the literature, the relationship between fibromyalgia and disease activity has been assessed in a few studies without discrimination between women and men.in this study, it was aimed to evaluate the relationship between fibromyalgia and disease activity in women with behçet's disease.

there are only a few studies in the literature evaluating the association of fibromyalgia with disease activity and clinical findings in behçet's disease. in the literature, the relationship between fibromyalgia and disease activity has been assessed without discrimination between women and men. behçet's disease is more active in men and fibromyalgia is more frequent in women. evaluating the relationship between fibromyalgia and disease activity in behçet's disease without gender discrimination may not be objective.there is not any study in literature evaluating relationship between fibromyalgia and disease activity in women with behçet's disease.in this study, it was aimed to evaluate the relationship between fibromyalgia and disease activity in women with behçet's disease.

Eligibility criteria:
inclusion criteria: * women diagnosed with behcet disease according to international study group criteria * patients older than 18 * patients younger than 75 exclusion criteria: * participants which were previously diagnosed with diabetes mellitus * participants which were previously diagnosed with chronic renal failure * pregnant women

Keywords: behcet's disease fibromyalgia disease activity
exercise regimen designed to improve functional mobility, body composition, and strength after breast conservation therapy for women with early stage breast cancer

Conditions: Breast Cancer

Summary: the purpose of this research study is to find out if a monitored group exercise program can increase strength, muscle mass and ability to move in women after treatment for early stage breast cancer.

this trial will assess the safety and feasibility of a monitored group exercise regimen utilizing high-load resistance training and functional exercises with compound movements in a group of women treated for early stage breast cancer with the goal of improving functional mobility, body composition, and strength after breast conservation therapy.

Eligibility criteria:
inclusion criteria: 1. age 30-70 years 2. women with a biopsy proven diagnosis of ductal carcinoma in situ or invasive carcinoma of the breast 3. women must have undergone breast conservation therapy with no neoadjuvant or adjuvant chemotherapy (adjuvant endocrine therapy is permitted) 4. bmi \> 25 kg/m2 or body fat% greater or equal to 31% 5. participants must have abstained from smoking for at least 12 months 6. women of child-bearing potential must verbally confirm lack of pregnancy prior to enrollment and have undergone a pregnancy test prior to initial of radiation therapy (standard protocol for radiation therapy). they should also consent to use adequate contraception during the course of the study. 7. women must be determined capable of engaging in resistance training as documented in treating radiation oncologist notes. 8. participants must have a schedule amenable to three prescheduled workout sessions per week, scheduled during the day. 9. women must complete a functional mobility screen (fms) and determined safe to engage in the workout regimen by the study personnel. exclusion criteria: 1. any treatment with chemotherapy for recent breast cancer treatment 2. mastectomy and/or lymph node dissection 3. uncontrolled hypertension or diabetes, defined as systolic blood pressure over 149, diastolic blood pressure over 99, and hemoglobin a1c greater than 8.9. 4. diabetic condition requiring the usage of insulin 5. severe arthritic, joint, cardiovascular, or musculoskeletal condition 6. inability to perform body weight squat exercise without pain assessed by treating radiation oncologist 7. history of myocardial infarction or coronary artery disease

Keywords: exercise
ucan: uniting couples in the treatment of anorexia nervosa

Conditions: Anorexia Nervosa

Summary: ucan is a research program funded by the national institute of mental health and is part of the unc eating disorders program. ucan aims to help couples work together in the treatment of anorexia nervosa. couples participate in ucan over a period of six months and return for follow-up treatment three months after the end of the original six-month period. patients receive weekly individual therapy, monthly psychiatry consultations, monthly dietary consultations in addition to being randomized to one of two types of weekly couples therapy. participation in ucan can help participants gain new confidence in facing anorexia as a team and can help us understand how best to involve partners in the treatment of eating disorders.

patients receive comprehensive eating disorder treatment at the unc eating disorders outpatient program in addition to couples therapy. eligibility: participants may be eligible if they are 18 or older, have anorexia nervosa and are currently living with a partner with whom they have been in a committed relationship for at least a year. the partner must also be willing to enter treatment.

Eligibility criteria:
inclusion criteria: * anorexia nervosa, * 18 years or older, * bmi 16 or higher, * in a committed relationship with a partner for 1 year or longer and currently living together. exclusion criteria: * alcohol or drug dependence in past year, * current significant suicidal ideation, * developmental disability that would impair the ability of the participant to benefit from the intervention, * psychosis, * bmi less than 16.

Keywords: eating disorders couples therapy
efficacy and safety of act-541468 in elderly subjects with insomnia disorder

Conditions: Insomnia Disorder

Summary: this study evaluates the dose response of act-541468 on the change of wake after sleep onset (waso) assessed by polysomnography (psg) on the first 2 days of each treatment period.

the study consists of 3 phases: a screening phase, a double-blind treatment phase consisting of 5 periods, and a safety follow-up phase. safety is monitored throughout the study.

Eligibility criteria:
inclusion criteria: * signed informed consent prior to any study-mandated procedure. * male or female aged ≥ 65 years. * body mass index (bmi): 18.5 ≤ bmi (kg/m2 ) \< 32.0 * insomnia disorder according to dsm-5 criteria. * self-reported history of insufficient sleep quantity. * insufficient sleep quantity as collected subjectively in the sleep diary and validated objectively by polysomnography. * insomnia severity index score ≥ 15. exclusion criteria: * any current history of sleep disorder other than insomnia, or any lifetime history of related breathing disorder, periodic limb movement disorder, restless legs syndrome, circadian rhythm disorder, rapid eye movement (rem) behavior disorder, or narcolepsy. * self-reported usual daytime napping ≥ 1 hour per day, and ≥ 3 days per week. * caffeine consumption ≥ 600 mg per day. * shift work within 2 weeks prior to the screening visit, or planned shift work during study. * travel ≥ 3 time zones within 1 week prior to the screening visit, or planned travel ≥ 3 time zones during study. * hematology or biochemistry test results deviating from the normal range to a clinically relevant extent as per judgment of the investigator. * ast and/or alt \> 2 × uln and/or bilirubin \> 1.5 × uln (except known history of gilbert's syndrome); * severe renal impairment (known or defined as estimated creatinine clearance \< 30 ml/min); * history or clinical evidence of any disease or medical condition or treatment, which may put the subject at risk of participation in the study or may interfere with the study assessments. * any circumstances or conditions, which, in the opinion of the investigator, may affect the subject's full participation in the study or compliance with the protocol.

Keywords: insomnia elderly polysomnography
prevalence of dementia and delirium in outpatient clinics (destan trial)

Conditions: Delirium in Old Age; Delirium Superimposed on Dementia; Delirium With Dementia

Summary: the aim of this study is to assess the prevalence and etiologic risk factors of delirium in outpatient geriatric patients and also hospitalized patients.

this study aimed to investigate the frequency of delirium and examines the association between delirium and other possible risk factors and prognostic factors (dementia etc.)

Eligibility criteria:
inclusion criteria: * we included all 65 years older patients who evaluated according to a comprehensive geriatric assessment that is consistently performed during admission to the outpatients' clinic of the hospital. exclusion criteria: * exclusion criteria were serious psychiatric disorders such as schizophrenia or major depression.

Keywords: delirium dementia mortality etiology outpatient
levetiracetam versus valproate in idiopathic generalized epilepsy

Conditions: Treatment of Idiopathic Generalized Epilepsy

Summary: this study aimed to compare the long-term efficacy and safety of levetiracetam and valproate in treatment of idiopathic generalized epilepsy.


Eligibility criteria:
inclusion criteria: * diagnosis of juvenile myoclonic epilepsy or generalized tonic-clonic seizure alone * regular monotherapy with levetiracetam or sodium valproate exclusion criteria: * poor drug adherence * pregnancy

Keywords: levetiracetam valproate idiopathic generalized epilepsy
the effectiveness of ultra-sound guided erector spinae block with betamethasone for management of truncal chronic post herpetic neuralgia.

Conditions: Postherpetic Neuralgia; Chronic Pain; Ultrasound Guidance; Erector Spinae Plane Block; Betamethasone

Summary: to investigate the effectiveness of ultra-sound guided erector spinae block (esb) with betamethasone as an adjuvant to standard medical protocol in the management of truncal chronic post herpetic neuralgia.

postherpetic neuralgia (phn) is a syndrome described as zoster-associated pain persisting for more than 3 months after resolution of an initial herpes zoster (hz) rash ("shingles").\[this condition is considered to be the most prevalent and challenging complication associated with hz infection. according to reports, around 75% of senior patients who contract hz are likely to experience it. the incidence of it was observed to be 38.1%, 27.0%, and 19.0% at 1 month, 3 months, and 6 months, respectively, following the onset of zoster. half of the patients who are more than 50 years have the risk of developing phn. it is noteworthy that the incidence of phn seems to be on the rise. erector spinae plane (esp) block is one of the newer interfascial techniques where the drug is injected below the erector spinae muscle to spread towards the costotransverse foramina and origin of dorsal and ventral rami where it is supposed to work at the origin of spinal nerves, based on cadaveric and contrast studies. cadaveric studies have also showed that a block at t5 level is sufficient to have unilateral multi-dermatomal sensory block ranging from t1 to l3. thus, this block serves the purpose of a paravertebral block without the risk of pleural injury. betamethasone is a long-acting corticosteroid with immunosuppressive and anti-inflammatory properties. it can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. betamethasone has potent glucocorticoid activity and negligible mineralocorticoid activity. the beneficial effects of injecting steroids could be because of sympathetic blockage, thereby inhibiting vasoconstriction and due to anaesthetization of the dorsal root ganglion and posterior spinal nerve.

Eligibility criteria:
inclusion criteria: * patients age between 18 and 75. * patients with american society of anesthesiologists (asa) ii and iii status. * patients diagnosed with truncal chronic post herpetic neuralgia( neuropathic pain persistent for more than 3 months from the onset of rash appearance ) exclusion criteria: * patients unable to comprehend the informed consent. * patients on long term opioid regimens. * patients with impairment in hepatic (alanine aminotransferase (alt) \>50 u/l, and/or aspartate aminotransferase (ast): \>45 u/l) or renal functions( creatinine level ≥1.5 mg/dl) * patients on anti-coagulation regimens. * patients with coagulation abnormalities (i.e. international normalized ratio (inr) ≥1.5 and/or platelets ≤50000) * local infection in the site of the block. * patients with body mass index (bmi) \> 35.
the use of noninvasive brain stimulation in post-traumatic stress disorder

Conditions: Post-traumatic Stress Disorder

Summary: the purpose of this trial is to study the effect of noninvasive brain stimulation in adults with post-traumatic stress disorder.

the purpose of this trial is to study the effect of noninvasive brain stimulation on symptoms severity in adults with post-traumatic stress disorder.

Eligibility criteria:
inclusion criteria: * 18-60 years old exclusion criteria: * transcranial magnetic stimulation ineligibility
effects of otago and gaze stabilization exercises on balance, gait and qol in elderly stroke patients

Conditions: Balance; Distorted; Gait, Hemiplegic; Quality of Life

Summary: to compare effects of otago exercises and gaze stabilization exercises on balance, gait and quality of life in elderly stroke patients

study design will be a randomized clinical trial . total 46 stroke patients will be recruited from riphah rehabilitation center and general hospital, lahore by using non-probability convenience sampling technique. patients will be randomized and allocated into two intervention groups based on inclusion and exclusion criteria. patients in group a will receive gaze stabilization exercises with conventional baseline treatment and group b patients will receive otago exercises with conventional baseline treatment. patients will receive treatment of 40 minutes per session for 5 days a week for 8 weeks. berg balance scale, dynamic gait index and stroke specific quality of life will be used as assessment tools. data will be analyzed by using spss 26 version.

Eligibility criteria:
inclusion criteria: * had ischemic or haemorrhagic stroke ≤6 months * berg balance scale (bbs) score between 35 and 45 * dynamic gait index score between 11 and 19 * mini-mental status exam scores \> 24 exclusion criteria: * participants with severe vision or hearing impairment * neurological disorders including epilepsy, alzheimer's disease, vertigo, parkinson disease, and stroke, muscular disorders which limit functional activity (oa, ra, etc) * medications that affect balance, severe cardiovascular conditions, recent lower limb injury or surgery * peripheral vestibular disorder

Keywords: balance; distorted gait, hemiplegic quality of life
use of baxter animated retching faces (barf) scale to measure nausea in children who speak spanish

Conditions: Postoperative Nausea and Vomiting

Summary: pediatric research in the management of nausea has been limited by the absence of a reliable method to quantify the intensity of this subjective symptom. in adults, the visual analog scale (vas) is an accurate tool, but this has not been shown to be reliable in young children. a scale is a series of points made on a line that will be used for measurement; a mark on the far left of the line shows little pain and the mark on the far right means alot of pain.

by default the most common objective outcome measure used in pediatric studies has been the incidence and number of emetic episodes. this measure, however, correlates poorly with the somatic subjective symptom of nausea. apfel et al have shown that 30-40% of adult patients undergoing surgery have post discharge nausea and / or vomiting while 12% have vomiting. these data on nausea in adults were based on a visual analog scale for nausea. there are no data on the incidence of postoperative nausea in children since the severity of symptoms are difficult to measure as younger children are known to be unable to use the vas reliably. recently a pictorial scale for measuring nausea, the baxter animated retching faces (barf) scale, has been developed and shown to have construct, content and convergent validity as an instrument to measure nausea in children. this was a two center study that was limited to children who could speak english. the clinical usefulness of this scale in determining the incidence of postoperative and post-discharge nausea in children has yet to be determined including the lowest age where it can be used reliably, the score associated with a patient's perception of a need for treatment, the minimum change in the scores of clinical relevance and the test-retest reliability when nausea is rated as not having changed. the score has also not been validated in children who speak spanish. this study is designed to provide the missing information and will specifically look at the spanish speaking population.

Eligibility criteria:
inclusion criteria: * (1) spanish speaking children (2) age \> 7 years but below 18 years (3) elective surgery (4) american society of anesthesiologists physical status 1-3 (free from major concurrent disorders) (5) free from nausea and / or vomiting in the previous 24 hours (6) cognitive and communicative ability to rate the intensity of symptoms as described below. exclusion criteria: * (1) inability to understand or speak spanish (2) developmental delay (3) blindness (4) impaired cognitive or communicative abilities including inability to rate the intensity of symptoms (5) surgical procedure where vision or hearing is anticipated to be impaired in the immediate postoperative period (6) nausea and /or vomiting within 24 hours of procedure, (7) patient or parental refusal to participate (8) pregnant females
emst in patients undergoing crt for hnca

Conditions: Head and Neck Neoplasms; Deglutition Disorders

Summary: this study is a randomized trial examining the impact of expiratory muscle strength training (emst) on maintenance of safe and efficient oropharyngeal swallow function in persons with cancer of the head and neck (hnca) undergoing treatment with radiation therapy or chemoradiotherapy (rt/crt).

thirty (30) persons with newly-diagnosed hnca who will be treated with rt/crt will be randomized to an 8-week program of either active expiratory muscle strength training (emst) + standard care or sham emst + standard care in order to examine the impact of emst on swallowing function. the training program will consist of 5 sets of 5 breaths, 5 days per week for 8 weeks, coincident with rt/crt. patients randomized to the active emst group will use the emst150 (product name) expiratory muscle strength trainer according to package instructions. those randomized to the sham emst group will use an emst150 device that has been modified to eliminate resistance to airflow. all subjects will be evaluated prior to initiation of cancer treatment (baseline assessment), 4 weeks into cancer treatment and again at the completion of cancer treatment (8 weeks after initiation of treatment). assessment will include measurement of maximum expiratory pressure (mep), a videofluoroscopic swallow study (vfss) to objectively document swallow function, and administration of swallow-related quality of life (qol) questionnaires.

Eligibility criteria:
inclusion criteria: * new diagnosis of cancer in the oral cavity, oropharynx, hypopharynx, or larynx; * planned treatment with primary radiotherapy with or without chemotherapy; * age 18 or older and able to provide consent; * ability to use the emst150 device (hold in mouth and maintain lip seal) exclusion criteria: * primary surgery to the head and neck (neck dissection is permitted); * unknown primary tumor; * primary cancers of the nasopharynx, paranasal sinuses, salivary glands and skin. * progressive neurologic condition affecting muscle strength (e.g. amyotrophic lateral sclerosis (als), parkinson's disease) * dysphagia not related to hnca (e.g. unresolved swallowing difficulty post-stroke or post--traumatic brain injury (tbi)) * prior history of head and neck radiotherapy

Keywords: oropharyngeal cancer laryngeal cancer swallow chemoradiation expiratory muscle strength training