Kornimate/medical-research-clean huggingface dataset:
effect of mulligan snag and diaphragmatic release on thoracic kyphosis

Conditions: Postural Kyphosis, Cervicothoracic Region

Summary: the aim of this study is to investigate the efficacy of mulligan snag mobilisation and diaphragmatic release on upper crossed syndrome

acquired postural disorders can be a consequence, to a large extent, of contemporary living and working conditions. some of the most typical factors include continuous use of mobile phones and computers, working in sedentary jobs. prolonged incorrect posture and reduced physical activity present a dis-balance in the musculature . it can also lead to vision issues, as well as headaches, musculoskeletal issues, and pain, as well as a multitude of other symptoms. upon the available research studies, there is not study conducted to investigate the effect of mulligan snag mobilization and diaphragmatic release in upper crossed syndrome patients this trial has four groups; one will receive diaphragmatic release + conventional, the second will receive mulligan snag mobilization, and conventional, the third will receive mulligan snag mobilization+diaphragmatic release+conventional, the fourth subjects will receive conventional

Eligibility criteria:
inclusion criteria: * age ranged from 17 to 22 years . * body mass index from 20 to 25 kg/m² . * all participants have an intensity of neck pain on vas (4-8) (moderate cases) . * the subjects were chosen from both sexes. * all participants have kyphosis angle ≥42° * all participants have mechanical neck pain and fhp (craniovertebral angle cva \< 49) cva of \< 49) . exclusion criteria: * malignancy * fractures of the cervical spine * cervical radiculopathy or myelopathy * vascular syndromes such as vertebrobasilar insufficiency * rheumatoid arthritis * neck or upper back surgery * taking anticoagulants * local infection * whiplash injury
videogame-based tool for job search and executive function improvement in adults with asd

Conditions: Autism Spectrum Disorder

Summary: this study aims to assess the efficacy of identifor, a strength- based, person-centered, vocational assessment tool to develop a more effective way to identify individual abilities, skills, and interests. identifor uses computer games specifically designed for young adults with asd.


Eligibility criteria:
inclusion criteria: * iq above 60 * diagnosis of asd as confirmed by qualified clinician (including dr. fung), and if necessary the administration of autism diagnostic interview-revised (adi-r) and/or autism diagnostic observation schedule-generic (ados-g) * age 18 to 55 * adults who are physically healthy * able to travel to work independently exclusion criteria: * dsm-5 diagnosis of other severe psychiatric disorder such as schizophrenia
a study of albuferon with ribavirin in interferon alfa naive subjects with chronic hepatitis c genotype 2 or 3

Conditions: Chronic Hepatitis C

Summary: a study of albuferon with ribavirin in interferon alfa naive subjects with chronic hepatitis c genotype 2 or 3.

a randomized, multi-center, open-label study to evaluate the efficacy and safety of albuferon (hgs 1008, recombinant human albumin-interferon alfa fusion protein) in combination with ribavirin in interferon alfa naive subjects with chronic hepatitis c genotype 2 or 3

Eligibility criteria:
inclusion criteria: * have a clinical diagnosis of chronic hepatitis c on the basis of detectable serum hcv rna during the screening period and at least a 6-month history of exposure to risk factors for hcv. * have never received treatment with an interferon alfa product or an interferon alfa combination product. * have hcv genotype 2 or 3. * have compensated liver disease with the following minimum criteria: white blood cell count (wbc) \>3,000/mm3, absolute neutrophil count (anc) \> 1,800/mm3, platelets \>100,000/mm3, hemoglobin (hb) \> 13 g/dl for males and \> 12 g/dl for females. exclusion criteria: * evidence of decompensated liver disease. * pregnant or lactating female. * history of any other medical disease or condition that would make the subject (in the opinion of the investigator) unsuitable for the study. * a current drug or alcohol addiction.

Keywords: hepatitis c chronic genotype 2 or 3 treatment naive
low-flow extracorporeal carbon dioxide removal in covid-19-associated acute respiratory distress syndrome

Conditions: ARDS; Hypercapnic Respiratory Failure; AKI

Summary: the study aims to investigate the efficacy of extracorporeal co2 removal for correction of hypercapnia in coronavirus disease 19 (covid-19)-associated acute respiratory distress syndrome

the prevalence of acute respiratory distress syndrome (ards) caused by covid-19 is approximately 8%. lung-protective ventilation is the current standard of care for ards. it limits lung and distal organ impairment, but is associated with hypercapnia in approximately 14% of patients with mild to moderate ards and almost all patients with severe ards. in this setting, early implementing of an extracorporeal co2 removal (ecco2r) therapy may prevent further escalation of invasiveness of therapy (eg, need for extracorporeal membrane oxygenation (ecmo)). a number of low-flow ecco2r devices are now available and some of those can be integrated into a renal replacement therapy (rrt) platform. this study aims to investigate the efficacy of an original ecco2r system used in conjunction with a rrt platform in hypercapnic patients with covid-19-associated mild-to-moderate ards with or without acute kidney injury (aki) necessitating rrt.

Eligibility criteria:
inclusion criteria: * mild-to-moderate ards according to the berlin definition * lung-protective ventilation with positive end-expiratory pressure (peep) \> 5 cm of water on mechanical ventilation expected to last \> 24 h * hypercapnia \<80 mmhg * bilateral opacities on chest imaging exclusion criteria: * age \< 18 years * pregnancy * patients with decompensated heart failure or acute coronary syndrome * respiratory acidosis with persistent partial pressure of blood carbon dioxide (pco2) levels \>80 mmhg * acute brain injury * severe liver insufficiency (child-pugh scores \> 7) or fulminant hepatic failure * decision to limit therapeutic interventions * catheter access to femoral vein or jugular vein impossible * pneumothorax
an investigational drug co-administered with insulin in patients with type 2 diabetes (0478-065)

Conditions: Type 2 Diabetes Mellitus

Summary: this is a study to evaluate the effectiveness and tolerability of an investigational drug in patients with type 2 diabetes (a specific type of diabetes) who are not currently treated with insulin.

the duration of treatment is 30 weeks.

Eligibility criteria:
inclusion criteria: * people between the ages of 18 and 70 who have a specific type of diabetes called type 2 diabetes which is currently being treated only with oral medication(s). (patients currently taking insulin would not be allowed to participate.) exclusion criteria: * people who have specific diseases (such as liver disease, gallbladder disease, pancreatitis, severe blood disorders or history of neoplastic diseases) which will be discussed by the study doctor and for which study participation would not be allowed.
study of epratuzumab in systemic lupus erythematosus

Conditions: Systemic Lupus Erythematosus

Summary: the purpose of the study is to evaluate the safety \& efficacy of epratuzumab with standard treatments for patients with sle.


Eligibility criteria:
inclusion criteria: * has sle by acr revised criteria (meets \<4 criteria); * has sle with at least one elevated lupus antibody; * has new onset of severe lupus disease flare in at least one body or organ system, excluding renal or neurologic exclusion criteria: * active severe cns or renal disease defined by bilag as level a * allergy to murine or human antibodies * antiphospholid antibodies and a history of thrombocytopenic events

Keywords: lupus antibody b-cell immunotherapy
pomx in the treatment of erectile dysfunction

Conditions: Erectile Dysfunction

Summary: pomx can be used as a treatment for erectile dysfunction.


Eligibility criteria:
inclusion criteria: * male 21 to 70 years old * erectile function domain score of 10-19 on the international index of erectile function (iief) * in a stable, monogamous relationship with a consenting female partner and willing to attempt vaginal sexual intercourse on at least one occasion per week on average during each study period * history of ed (clinically defined as the inability to attain and maintain an erection of the penis sufficient to permit satisfactory sexual intercourse) of at least 3 months duration * treated previously with a pde-5 inhibitor with a satisfactory response, as defined by the patient. * signed informed consent exclusion criteria: -the presence of any of the following excludes a subject from study enrollment: ed caused by untreated endocrine disease, i.e., hypopituitarism, hypothyroidism, hypogonadism * a diagnosis of situational psychogenic ed * significant penile pathology, including but not limited to curvature, fibrosis, sexually transmitted disease, and penile implant * clinically significant hepatic, renal, neurological disease, diabetes mellitus, spinal cord injury, significant coronary heart disease, significant neurological disease or hepatitis b and/or c * history of prostate cancer or prostate surgery other than a transurethral resection of the prostate * history of alcoholism within the previous 2 years * current consumer of three or more units of alcohol per day (1 unit is equivalent to 1 glass of wine, 1 pint of beer, or 1 shot of hard liquor) * taking ed therapy (prescription medications, over-the-counter medications, herbal preparations or medical devices) after the screening visit * participation in another study with an investigational drug or device during the 30 days prior to study entry * has a condition interfering with his ability to provide informed consent or comply with study instructions

Keywords: ed pomx pomegranate erectile dysfunction
effect of iontophoresis vs. ultrasound and iontophoresis in plantar fasciitis". plantar fasciitis"

Conditions: Iontophoresis; Ultrasound Therapy; Complications; Fasciitis, Plantar; Pain, Acute

Summary: plantar fasciitis is inflammation of plantar fascia.the main symptom of plantar fasciitis manifests itself as localized pain in the inner area of the foot and increases in intensity after long periods of standing or resting. its etiology is multifactorial and risk factors include overweight, female gender, physical exercise (impact sports), biomechanical imbalances of the foot and possible dysfunction of the functional twin-ankle-plantar system.generally speaking, conservative measures are recommended as initial treatment for plantar fasciitis, and in situations where these are ineffective, corticosteroids are sometimes administered. at the local level, the route of administration can be by infiltration or iontophoresis.iontophoresis consists of administering a drug through the skin by applying an electric current locally. this technique can be considered as a safe and effective method within the sltf (transcutaneous drug delivery systems). it consists of introducing ions through the skin by means of electricity using a direct current, with an electrode carrying a positive charge (anode) and a negative charge (cathode). its administration is produced thanks to the repulsive force to carry the compound through the skin by means of galvanic current. this study aims to assess whether treatment with iontophoresis in subjects with plantar fasciitis can show a more positive evolution in pain after a 6-week treatment period (treatment frequency: 1 time per week) versus ultrasound (3 times per week) for 6 weeks.


Eligibility criteria:
inclusion criteria: * plantar fasciitis * fascia thickness (greater or equal to 4mm). exclusion criteria: * skin lesion * sensory neuropathy * current use of plantar supports * taking pharmacological treatment (15 days) or previous infiltrations (6 months) * previous surgery or fractures of the lower limb * pregnancy * allergy to the applied drugs.
a phase ii trial of ifosfamide, etoposide, cytarabine, and methotrexate (ivam) chemotherapy for refractory or relapsed diffuse large b cell lymphoma

Conditions: Diffuse Large B Cell Lymphoma

Summary: a phase ii trial of ifosfamide, etoposide, cytarabine, and methotrexate (ivam) chemotherapy for refractory or relapsed diffuse large b cell lymphoma

diffuse large b-cell lymphoma is currently used as a standard treatment, with a combination of chemotherapy (r-chop), which includes rituximab. however, the survival rate is very poor if the primary treatment is refractory or relapsed within a year or less. the duration of these patients ' lives is around one year and the five-year survival rate is 15-20 %. thus, a new treatment strategy is needed to improve the survival of the patient with dlbcl, which are either refractory and relapsed.

Eligibility criteria:
inclusion criteria: * written informed consent * histologically confirmed adult patients diagnosed with dlbcl refractory or relapsed. * large scale b cell lymphoma not received asct(autologous stem-cell transplantation ) after primary chemotherapy * at least one measurable lesion * ≥1 cm in greatest transverse diameter by spiral ct * ≥2 cm in greatest transverse diameter by conventional ct * ≥1 cm in visible skin lesion * ≥2 cm in digital exploration * performance status: eastern cooperative oncology group (ecog) 0-2. * age 19\~59yrs * muga(multiple gated acquisition scan ): non-clinical significant and 2d-echo( cardiac index ≥ 50 % ) * adequate renal function: serum creatinine level \< 2.0 mg/dl(177μmol/l) adequate liver functions: transaminase (ast/alt) \< 3 x upper limit of normal value (or \< 5 x uln in the presence of dlbcl involvement of the liver), bilirubin \< 2 x upper normal value (or \< 5 x upper limit of normal in the presence of dlbcl involvement of the liver) * adequate hematological function: hemoglobin ≥ 9.0 g/dl absolute neutrophil count (anc) ≥ 1,500/μl and platelet count ≥ 75,000/μl, * a negative serum or urine pregnancy test prior to treatment must be available both for pre menopausal women and for women who are \< 1 years after the onset of menopause. exclusion criteria: * pre-treatment for asct * central nervous system (cns) involvement by lymphoma * prior history of malignancies other than lymphoma (except for treated non melanoma skin cancer, early gastric cancer or carcinoma in situ of the cervix or breast or untreated prostatic cancer without any plan for a treatment) unless the patient has been free of the disease for ≥ 5 years * pregnant or lactating woman, childbearing potential not employing adequate contraception * active uncontrolled infections(bacterial, viral, fungus) * other serious illness or medical conditions * other experimental drug under investigation, or concomitant chemotherapy, hormonal therapy, or immunotherapy.
comparing the reciprocal inhibition method and post-isometric inhibition method of muscle energy technique on the spinal reflex excitability in healthy subjects

Conditions: Relaxation; Joint; Limitation, Mobility; Relaxation; Lumbosacral

Summary: this a cross-over study to compare the effect of two different muscle energy techniques (met) including post-isometric inhibition and reciprocal inhibition on the spinal reflex excitability. the study contains two experimental groups, while one group will receive post-isometric inhibition met in the first stage and reciprocal inhibition met in the second stage, the other group will receive reciprocal inhibition met in the first stage and post-isometric inhibition met in the second stage.

reciprocal inhibition met works based on the two mechanisms a) voluntary activation of agonist muscle that is simultaneously accompanied by the inhibition of the antagonist muscles or b) the activation of muscle spindle which causes a reflexive contraction in the agonist muscle (known as the stretch reflex) and relaxation of the antagonist muscles. by using this method, the activation of agonist muscles may inhibit or deactivate the antagonist muscles which may permit the therapist to introduce further rom to the affected joint. the other method of met is post-isometric relaxation which works based on the two mechanisms including; 1) activation of golgi tendon organs (gto) that located between the muscle belly and its tendon and 2) presetting muscle spindles by muscle contraction witch project information to the spinal cord via afferent type ii fibers and through a complex central control systems, the spindle is preset to adjust the tone of the muscle. it seems that moderate isometric contraction of muscle may preset the muscle spindle and cause a post-isometric relaxation within the agonist muscles which now can be stretched further, and this may permit the therapist to introduce further rom to the affected joint and help to improve joint mobilization.

Eligibility criteria:
inclusion criteria: * without current low back pain exclusion criteria: * suffering from pain in the cervical, thoracic and lumbar spine, * presenting signs of radiculopathy or peripheral neuropathy such as specific patterns of numbness and muscle weakness, * any history or signs of joint instability, healing fractures, malignancy, open wounds, sutures, severe rheumatoid arthritis.

Keywords: spinal reflex excitability muscle relaxation h reflex
comparing two injection sites of local anesthetic for hand surgery

Conditions: Hand Injury; Wrist Injury; Finger Injury

Summary: the purpose of this study is to compare two different injection sites for local anesthesia in patients having hand surgery. the hypothesis is that subjects receiving injections around the three nerves of the forearm will provide faster pain control and greater patient satisfaction than patients having one injection closer to the shoulder.


Eligibility criteria:
inclusion criteria: * patients ≥ 18 years of age undergoing unilateral hand, wrist, or finger surgery * ability to understand and provide informed consent * american society of anesthesiologists (asa) status i-iii exclusion criteria: * patient refusal or inability to provide informed consent * true allergy, not sensitivity, to any of the following substances: local anesthetics, midazolam, fentanyl, hydromorphone, propofol * pregnancy * severe hepatic impairment * evidence of infection at or near the proposed needle insertion site * any sensorimotor deficit of the ipsilateral upper extremity, whether acute or chronic, as determined by the pi and designee * pulmonary disease of any kind that is uncontrolled or severe in nature * chronic pain patients, defined as someone diagnosed with chronic pain or a chronic pain condition, under the care of a chronic pain physician, or taking oral/intravenous narcotics consistently for 30 days prior to surgery

Keywords: hand surgery wrist surgery finger surgery anesthesia regional anesthesia postoperative pain
effect of health education on promoting influenza vaccination health literacy

Conditions: Vaccination; Infection; Influenza

Summary: the goal of this cluster randomized controlled trial is to evaluate the effect of health education interventions on influenza vaccination rates and health literacy in primary school students in the city of dongguan in china. individuals aged 7 to 12 years who are in grades 4-5 in primary schools in dongguan will be enrolled. 20 primary schools will be randomly selected, with half designated as intervention group schools and the remaining half as control group schools. the intervention group will receive a monthly health education intervention focused on influenza vaccination for 5 months, while the control group will continue with their routine school health education for 5 months. researchers will compare the differences in influenza vaccination rates and influenza vaccination health literacy levels between the intervention and control groups after 5 months to see if health education can promote influenza vaccination health literacy among primary school students.

introduction: influenza is a major public health threat, and vaccination is the most effective prevention method. however, vaccination coverage remains suboptimal. low health literacy regarding influenza vaccination may contribute to vaccine hesitancy. this study aims to evaluate the effect of health education interventions on influenza vaccination rates and health literacy. methods and analysis: this cluster randomized controlled trial will enroll 3036 students in grades 4-5 from 20 primary schools in dongguan city, china. schools will be randomized to an intervention group receiving influenza vaccination health education or a control group receiving routine health education. the primary outcome is influenza vaccination rate. secondary outcomes include health literacy levels, influenza diagnosis rate, influenza-like illness incidence, and vaccine protection rate. data will be collected through questionnaires, influenza surveillance, and self-reports at baseline and study conclusion. ethics and dissemination: ethical approval has been sought from the ethics committee of the school of public health, sun yat-sen university. findings from the study will be made accessible to both peer-reviewed journals and key stakeholders.

Eligibility criteria:
inclusion criteria: * primary school students within the age range of 7-12 years. * students and their parents who voluntarily agree to participate in the study and provide signed informed consent. * permanent residents of dongguan city who are expected to complete the project without transferring schools during the study period. exclusion criteria: * individuals with contraindications to influenza vaccination, who have recently received an influenza vaccination, diagnosed with influenza or confirmed as influenza-like cases at the commencement of the study. * unwilling to participate in the project.

Keywords: health education health literacy schools china