Kornimate/medical-research-clean huggingface dataset:
the influence of needle diameter on post dural puncture headache

Conditions: Post-Dural Puncture Headache

Summary: the purpose of this study is to determine whether injection needle pen point type 'pp gauge 25' should be recommended as a primary choice of needle (in stead of 'pp gauge 27') for healthy pregnant women who at delivery (vaginal or cesarean section) get spinal anesthesia.


Eligibility criteria:
inclusion criteria: * healthy * pregnant * spinal anesthesia at delivery (vaginal delivery or cesarean section emergency grade 2-4) * informed consent exclusion criteria: * chronic headache * (attempt to) epidural anesthesia

Keywords: delivery, obstetric analgesia, epidural injections, epidural needles cesarean section
stair descending vs. stair ascending exercise

Conditions: Aging; Heart Failure; Sarcopenia

Summary: the aim of the present project is to compare the acute and chronic effect of stair descending versus stair ascending exercise on muscle damage and performance in elderly males with chronic heart failure.

study design: twelve elderly males with chronic heart failure, new york heart association class i-ii, will participate in this study. participants will be allocated into two equally-sized groups: a stair descending group (n = 6) and a stair ascending group (n = 6). at the beginning of the study, the volunteers will perform an acute bout of stair descending or stair ascending exercise on an automatic escalator (4 sets of 3 min each, speed will be set at 45 steps∙min-1). step height will be 20.5 mm. before and at day 2 post exercise, physiologic measurements will be performed and blood samples will be collected. then, participants will carry out six weeks of stair descending or ascending training consisting of three exercise sessions per week (the first two weeks the speed will be set at 45 steps∙min-1, the next two weeks at 50 steps∙min-1 and the last two weeks at 55 steps∙min-1 for both groups). afterward, they will repeat the acute stair descending or ascending protocol, as carried out at the beginning of the study, and the same physiologic measurements will be performed and blood samples will be collected. measurements: isometric (at 90 knee flexion), concentric and eccentric peak torque at 60o∙s-1of quadriceps femoris, pain-free range of motion, delayed onset muscle soreness and creatine kinase will be measured.

Eligibility criteria:
inclusion criteria: * chronic heart failure (new york heart association class i-ii) * subject provides written informed consent * personal physician of the participants provides written informed consent exclusion criteria: * smoker * consumed any nutritional supplement the last 3 months * performed intense eccentric exercise the last 6 months * non caucasian

Keywords: eccentric exercise aging heart failure muscle strength loss sarcopenia
optimal timing of coronary artery bypass grafting in hemodynamically stable patient after myocardial infarction and definition of poor prognostic factors. pilot study

Conditions: Cardiac Surgery

Summary: acute coronary syndromes (acs) represent the leading cause of death in france. their incidence is increasing due to population aging and to the persistence of cardiovascular risk factors. currently, revascularization surgery remains outside the emergency treatment, because early performed, it tends to lead to extension and hemorrhage of the infarcted area, because of the cpb, aortic clamping, cardioplegia, and other heart manipulation. however, cabg are indicated as an emergency in some situations of stemi: threat of infarction of an extended territory without favorable anatomy to angioplasty, anatomy not favorable to angioplasty associated with cardiogenic shock or persistent ischemia, acute complications of myocardial infarction (massive mitral insufficiency, interventricular communication, parietal rupture) requiring surgery under cpb with concomitant bypass surgery or failure of angioplasty (proximal coronary dissection). operative mortality is high; 15 to 20% for patients operated 12 to 48 hours after ami and 4-5% for those operated after 48 hours. nevertheless, it seems legitimate to study if there would be a place for primary surgical revascularization in case of patient with hemodynamically stable acs, in order to limit myocardial ischemia, spread of necrosis, to limit the risk of recurrence, and the consequences of low cardiac output. performing a complete early surgical revascularization could limit the ischemia-reperfusion syndrome and anticipate the occurrence of cardiogenic shock.

trial on medical records only

Eligibility criteria:
inclusion criteria: * patients presenting acute myocardial infarction with hemodynamic stability at the diagnosis * patients undergoing coronary artery bypass in dijon university hospital exclusion criteria: * patients with acute pulmonary oedema * patients with cardiorespiratory arrest before coronary angiography * hemodynamically unstable patient at diagnosis * patients requiring combined surgery * patients with unstable angina
hypophosphatemia as a predictive marker of mortality during sepsis in icu

Conditions: Hypophosphatemia; Infection

Summary: retrospective study in the 3 intensive care units of the brest teaching hospital (france) during a 18-months period (june 2014 -december 2015) to study the independent association between hypophosphatemia and 90-day mortality.


Eligibility criteria:
inclusion criteria: * blood stream infection exclusion criteria: * less than 18 years old
treatment of coronary in-stent restenosis (isr) by a sirolimus coated or a paclitaxel coated balloon

Conditions: Coronary Restenosis

Summary: treatment of coronary in-stent restenosis (isr) by a sirolimus coated sequent® scb rapid exchange ptca balloon catheter or a paclitaxel coated sequent® please ptca balloon catheter

experimental intervention: predilatation of coronary isr with poba followed by a sirolimus coated sequent®scb balloon balloon (sirolimus 4.0 μg/mm²) control intervention: predilatation of coronary isr with poba followed by a paclitaxel coated sequent®please balloon or sequent®please neo balloon (paclitaxel 3.0 μg/mm²) duration of intervention per patient: minutes follow-up per patient: 30 days telephone call; 6 months angiographic + 12 months clinical follow up

Eligibility criteria:
inclusion criteria: * 18 years of age * clinical evidence of stable or unstable angina (acute coronary syndrome) or a positive functional study * patients with ≤ 2 primary in-stent restenosis (isr) lesions (≥ 70% diameter stenosis by visual estimation or ≥50% and positive functional study) including margin-stenosis with max 5 mm distance to the stent exclusion criteria: * chronic renal insufficiency with serum creatinine levels \> 2.0 mg per deciliter * known hypersensitivity or contraindications to aspirin, heparin, clopidogrel, ticlopidine or sirolimus, and sensitivity to contrast media not amenable to premedication * concomitant medical illness associated with a life-expectancy of less than two year * lesion length (isr) \> 35 mm, reference vessel diameter \< 2.5 mm
clinical follow-up of direct/indirect bridge, orthodontic and periodontal splint by using fibre-reinforced composite

Conditions: Tooth Loss; Tooth Mobility

Summary: the purpose of this study is to determine whether fibre-reinforced composite resin restorations are effective for single tooth replacement, elimination of tooth mobility following periodontal treatment and as an orthodontic retainer.

adhesive dentistry is based on preventive dental approach. in presence of such advanced and minimally invasive techniques, destructive treatment methods should not be preferred for clinical situations, such as missing single tooth cases, tooth mobility following periodontal treatment and prevention of relapse after orthodontic treatments. glass fibre is a reinforcement material, and increases the flexibility of the material together which it has been used. fibre-reinforced applications by using direct or indirect techniques. this material and method is easily applicable, biocompatible, repairable and economical on a high extent.

Eligibility criteria:
inclusion criteria: * referring patients for missing tooth replacement or fixation of tooth mobility following periodontal treatment or maintenance of teeth in corrected positions following orthodontic treatment exclusion criteria: * insufficient interocclusal distance * poor oral hygiene

Keywords: fiberglass reinforced resins
an observational study on cardiovascular involvement in covid recovered patients

Conditions: Gender Discrimination; Cardiac Event; Complication

Summary: aim of the study is to evaluate the prevalence and bring awareness ofcardiovascular complications in covid-19 recovered patients. study is conducted at single site, which is srinivasa heart centre, warangal, telangana state in india for the duration of 4 months. the sample size is calculated 500 patients and the study is cohort, observational study. patient consent has been taken before enrolment.

the aim of the study is to evaluate the prevalence and bring awareness of cardiovascular complications in covid-19 recovered patients. objectives of the study: 1. to study causes and risk factors of cardiac disorders associated with covid-19 2. to identify different types of cardiac symptoms patients, present with 3. to study the impact of co-morbidities on covid-19 recovered patients 4. to study treatment patterns and duration of therapy plan to study: * to select the patient based on inclusion and exclusion criteria * to collect the patient information from case sheets and by patient interaction * to identify different types of cardiac disorders related to covid-19 or its treatment regimen * to study the management of covid-19 complication and related cardiovascular disorders study sites: srinivasa heart centre, warangal (t.s) study design: observational cohort study study duration: 4 months subject eligibility: 1. inclusion criteria * patients who are willing to participate * patients having previous covid-19 treatment record * prescriptions reported during the study period * the prescription which is legible and complete 2. exclusion criteria * patients who are not willing to participate * the patient having no history of covid-19 and available data source of the data: 1. review of patient case sheet, prescription and lab reports 2. personal interaction with patients and caregivers sample size: 500 patients

Eligibility criteria:
inclusion criteria: * patients who are willing to participate * patients having previous covid-19 treatment record * prescriptions reported during the study period * the prescription which is legible and complete exclusion criteria: * patients who are not willing to participate * the patient having no history of covid-19 and available data

Keywords: cardiovascular involvement covid 19 disease gender difference
autonomic nervous system function - hypertension

Conditions: Hypertension

Summary: the life university center for chiropractic research is conducting a research study to better understand the physiological differences, in terms of autonomic nervous system function, between individuals with hypertension and control individuals with out hypertension. data will be gathered using heart rate variability (hrv), and galvanic skin response (gsr). a series of tests will be conducted to elicit autonomic nervous system responses. these tests include cold face test (mammalian dive reflex), cold pressor test, sit to stand, and the valsalva maneuver.

the objective of the study is to ascertain the level of autonomic health in persons with hypertension versus a healthy population. further, via the implemented protocol, the study will attempt to develop a sequence of autonomic nervous system tests to be used in future studies and clinical settings

Eligibility criteria:
participants will be included in the hypertension group if they present with the following: * hypertension, defined as: * self-reported or previously diagnosed with elevated resting state blood pressure (120-129 systolic and less than 80 mmhg diastolic) or stage 1 hypertension with a blood pressure of systolic between 130- and 139-mm hg with a diastolic of 80-89 mmhg. * or medically diagnosed and managed stage 2 hypertension with blood pressure of systolic between 140- and 159-mm hg or diastolic 90 and 99 mm * between the ages of 18-65 * able to wear a monitor on their right wrist. * able to wear a pulse oximeter on their left hand. participants will be included in the healthy group if they present with the following: * between the ages of 18-65 * able to wear a monitor on their right wrist. * able to wear a pulse oximeter on their left hand.
clinical stories and psychological experiences of cancer patients

Conditions: Tumor

Summary: the purpose of the study is to collect and analyze information from the multidimensional assessment of cancer patients (medical, psychological, psychometric, biological, etc.) treated at the fondazione policlinico universitario agostino gemelli irccs. the collection of information will allow to investigate the possible presence of correlations between psychological aspects and clinical medical conditions of the person during the course/treatment of cancer. in the course of the study, the possible presence of previous stressful and/or traumatic events, and the presence of psychological, post-traumatic and/or dissociative symptoms during treatment will be explored. any correlations between medical conditions and psychological, emotional and behavioral characteristics will also be explored. finally, it will be possible to investigate the effectiveness of psychological interventions that are carried out according to clinical practice.


Eligibility criteria:
inclusion criteria: * individuals between 18 and 99 years old; * individuals with a diagnosis of current oncologic disease and in active oncologic treatment at the hospital where the study is conducted; * individuals with a history of oncologic disease who have completed oncologic treatment or in follow-up at the hospital where the study is conducted; exclusion criteria: * non-signing of informed consent; * non-signing of consent/assent by patient/legal guardian; * patients with cognitive impairment or legal disqualification; * clinical/medical or psychological condition that does not allow completion of self-report questionnaires;
reliability and validity of the turkish version of the 6-item carpal tunnel syndrome symptoms scale

Conditions: Carpal Tunnel Syndrome; Symptoms and Signs

Summary: carpal tunnel syndrome (cts) is a common condition that affects the median nerve that usually cause numbness, tingling, pain, and weakness in the hand and fingers. while definitive diagnosis is made with nerve conduction studies, the patient's history and physical examination findings lead the clinician to the diagnosis of cts. using factor analysis and item response theory methodology, atroshi et al. developed a short 6-item version of the symptom severity scale to ease respondent burden while maintaining the psychometric properties of the boston carpal tunnel questionnaire. it has been demonstrated that the 6-item cts symptom scale has good reliability, validity and responsiveness. the aim of this study was to evaluate the reliability and construct validity of the turkish version of the 6-item cts symptoms scale for cts.

carpal tunnel syndrome (cts) is a common condition that affects the median nerve that usually cause numbness, tingling, pain, and weakness in the hand and fingers. while definitive diagnosis is made with nerve conduction studies, the patient's history and physical examination findings lead the clinician to the diagnosis of cts. the use of patient-completed disease-specific scales is increasing in clinical research and patient follow-up. various scales have been developed to question symptoms related to hand problems. the boston carpal tunnel questionnaire and the 6-item cts symptom scale are the scales that have been shown to be used to assess symptom severity and for diagnostic screening. using factor analysis and item response theory methodology, atroshi et al. developed a short 6-item version of the symptom severity scale to ease respondent burden while maintaining the psychometric properties of the boston carpal tunnel questionnaire . it has been demonstrated that the 6-item cts symptom scale has good reliability, validity and responsiveness. the aim of this study was to evaluate the reliability and construct validity of the turkish version of the 6-item cts symptoms scale for cts.

Eligibility criteria:
inclusion criteria: * presence of numbness or tingling in at least two radial side fingers, * a positive phalen's test result, * symptoms lasting more than three months * consistent nerve conduction study with cts. exclusion criteria: * those with no electrophysiological evidence of cts, * diabetes or other metabolic diseases, * any other inflammatory diseases.

Keywords: carpal tunnel syndrome boston carpal tunnel questionnaire validity turkish adaptation reliability 6-item carpal tunnel syndrome symptoms scale
safety and tolerability of vortioxetine (luaa21004) - open label extension study

Conditions: Depressive Disorder, Major

Summary: the purpose of this study is to determine the long-term safety and tolerability of vortioxetine, once daily (qd), in participants with major depressive disorder.

depression has been recognized as a chronic illness that imposes a significant burden on individuals, families and society. major depressive disorder (mdd) is among the most important causes of disability worldwide, in both developing and developed countries. major depressive disorder is reported to be the most common mood disorder, with a lifetime prevalence of about 15% and as high as 25% in women. major depressive disorder is characterized by the presence of 1 or more major depressive episodes that presents with depressed mood, loss of interest or pleasure, disturbed sleep or appetite, low energy, feelings of guilt or low self-worth, and poor concentration. this is a multicenter extension study designed to allow eligible patients who have completed short-term efficacy and safety studies luaa21004_315 (nct01153009), luaa21004_316 (nct01163266) and luaa21004_317 (nct01179516) to receive the 52-week treatment with vortioxetine in this open-label extension study. participants are expected to return to the site for approximately 13 visits. a safety follow-up call will be made 4 weeks after completion of the 52-week treatment period.

Eligibility criteria:
inclusion criteria: * has completed either study luaa21004_315 ( nct01153009), luaa21004_316 (nct01163266), or luaa21004_317 (nct01179516) immediately prior to enrollment in the extension study (ie, the baseline visit is the same visit as the week 8 \[lu aa21004_317\] or week 10 \[lu aa21004_315 or lu aa21004_316\] assessment of the preceding protocol). * suffers from a recurrent major depressive episode) as the primary diagnosis according to diagnostic and statistical manual of mental disorders, fourth edition, text revision (dsm-iv-tr) criteria (classification code 296.3x) at entry into the prior study. * twelve-month continuation treatment with lu aa21004 is indicated for the treatment of this participant according to the opinion of the investigator. * females of childbearing potential who are sexually active with a nonsterilized male partner agree to routinely use adequate contraception throughout the duration of the study. exclusion criteria: * has major depressive disorder for whom other psychiatric disorders (mania, bipolar disorder, schizophrenia, or any psychotic disorder) have been diagnosed during the prior study. * in the investigator's clinical judgment, has a significant risk of suicide and/or a score of ≥5 points on item 10 (suicidal thoughts) of the montgomery åsberg depression rating scale (madrs). * in the opinion of the investigator, is unlikely to comply with the clinical study protocol or is unsuitable for any reason. * has a clinically significant moderate or severe ongoing adverse event related to study medication from the prior study. * has used/uses disallowed concomitant medication.

Keywords: depression melancholia paraphrenia drug therapy
a 3 month, randomized, open label, multi-center study of technosphere/insulin compared to insulin aspart in subjects with type 1 diabetes mellitus receiving insulin glargine

Conditions: Diabetes Mellitus, Type 1

Summary: a 3 month, randomized, open label, multi-center study of technosphere/insulin compared to insulin aspart in subjects with type 1 diabetes mellitus receiving insulin glargine


Eligibility criteria:
inclusion criteria: * type 1 diabetes currently receiving sc insulin at mealtimes for at least 3 months * bmi \<40 kg/m squared * hba1c greater than or equal to 7% and less than or equal to 11.5% * serum creatinine less than 2 for males and less than 1.8 for females * acceptable pulmonary function exclusion criteria: * significant hepatic disease * previously diagnosed pulmonary disease, ketoacidosis of evidence of severe secondary complications of diabetes
mrd monitoring in lung cancer after resection

Conditions: Lung Cancer

Summary: the conception of molecular residual disease (mrd) extending from hematologic tumor to solid tumors. evidences supporting mrd evaluation for lung cancer by liquid biopsy has gradually accumulated, especially circulating tumor dna (ctdna). in this observational study, the investigators prospectively enroll stage i-iiia non-small cell lung cancer (nsclc) patients who underwent complete resection. preoperative blood sample, tumor tissue and dynamic postoperative blood samples are collected continuously for mrd detection. this study aim to explore the prognostic value of mrd for stage i-iiia nsclc patients after complete resection.

there will be a rapid surge in research about molecular residual disease (mrd) for solid cancer in the near future. however, mrd differed significantly between tumor types and between contexts; there continues to be a considerable lack of awareness and knowledge about using mrd in lung cancer. hence, this study aims to investigate the value of mrd in nsclc patients who underwent complete resection. preoperative blood sample (20ml), tumor tissue and dynamic postoperative blood samples (20ml) are collected continuously for mrd detection. the follow-up was performed once every 3 to 6 months. the primary objective of this study is to assess the prognostic value of mrd for stage i-iiia nsclc patients after complete resection.

Eligibility criteria:
inclusion criteria: * diagnosis of histologically confirmed nsclc (who 2015 classification) with resectable (stage i-iiia) disease. * complete resection * age ≥18 years at the time of screening * capable of giving signed informed consent exclusion criteria: * mixed small cell and nsclc histology * rx, r1 or r2 resection * history of other malignant tumors within 5 years

Keywords: molecular residual disease circulating tumor dna disease relapse predictive value