Kornimate/medical-research-clean huggingface dataset:
the use of sennas for prevention of post-operative constipation after urogynecologic surgery

Conditions: Constipation

Summary: we are doing this study to see if using an over the counter mild laxative, sennas, there is a difference in time required to have a bowel movement in women who are having surgery for prolapse (when your uterus and/or vagina drop after childbirth or with age) and/or incontinence (when you leak urine or stool without your control) as compared to a sugar pill or placebo.

right now, doctors use mild laxatives and stool softeners to help you have a bowel movement earlier and with less pain after surgery. sometimes if the stool softener or mild laxatives do not work, you may need to use stronger laxatives or enemas. we want to see if specifically using sennas is better for having a bowel movement soon after surgery and with less pain. sennas is fda approved for constipation. it has a stool softener and a mild laxative and has been shown to be safe and effective for treating constipation.

Eligibility criteria:
inclusion criteria: women undergoing pelvic reconstructive surgery, including any combination of: * posterior/rectocele repair * paravaginal repair * anterior/cystocele repair * suburethral sling * abdominal sacrocolpopexy * midurethral sling (obturator pass) * burch urethropexy * midurethral sling (retropubic pass) * colpocleisis/colpectomy * uterosacral ligament suspension * sacrospinous ligament fixation * enterocele repair * anal sphincter repair * perineorrhaphy * use of graft material (synthetic or biologic) of any form/size does not affect inclusion, use of laparoscopy or robotic-assisted laparoscopy does not affect inclusion exclusion criteria: * male * pregnancy (based on positive urine or serum ß-hcg measurement preoperatively in women who are not menopausal or have prior hysterectomy) * concurrent bowel resection, * hirschsprung's disease or gastroparesis, * irritable \& inflammatory bowel disease (crohn's disease/ulcerative colitis) formally diagnosed, * clostridium difficile colitis during present hospitalization * inability to understand written study material, * inability to give consent * rectal bleeding or presently diagnosed colorectal cancer, * documented preoperative daily use of sennas for more than 3 weeks, * known allergy to sennas * inability to use suppositories/enemas

Keywords: constipation sennas
drug use investigation for arepanrix® (h1n1)

Conditions: Influenza

Summary: this post-marketing surveillance study is designed to collect safety information such as post-vaccination adverse events and adverse reactions from recipients of arepanrix® (h1n1) intramuscular injection. the following items will be investigated as priority investigation items. \ 1. allergic reactions 2. anaphylaxis


Eligibility criteria:
inclusion criteria: * subjects who receive arepanrix® intramuscular injection for the first time exclusion criteria: * not applicable
assessing pain by the paindetect questionnaire (pdq)

Conditions: Inflammatory Arthritis; Spondylarthropathies; Rheumatoid Arthritis; Psoriatic Arthritis

Summary: prospective cohort study using drug survival rates to assess the predictive value of the pdq when used to classify patients into a non-neuropathic pain phenotype group (score \<13) or a neuropathic pain phenotype group (score ≥13)

the original paindetect questionnaire (pdq) danbio study was a survey among all danbio users having an arthritis diagnosis 'pain and pain mechanisms in patients with inflammatory arthritis: a danish nationwide cross-sectional danbio registry survey'. the pdq was implemented onto the danbio touch screens for a period of 6 months in 2013-14 and data from more than 7000 individual patients were collected. the overall background for the study was that central pain mechanisms may be prominent in subsets of patients with rheumatoid arthritis (ra), psoriatic arthritis (psa) and other spondyloarthritis (spa). the study showed that approximately 50 % of patients experienced significant pain levels and that a high pdq score was associated with higher levels of pain and das28 but not with markers of inflammatory activity such as crp and swollen joint count. furthermore, indications of more frequent bio-switch in the pdq groups showing neuropathic pain features were found. the aim of this study is to examine the association between drug retention of biological dmards (bdmards) and the pdq pain classification categories (i.e. non-neuropathic vs. neuropathic features) and to investigate whether this categorization is predictive of drug retention and changes in clinical outcomes over a 5-year period.

Eligibility criteria:
inclusion criteria: * registered in danbio * having inflammatory arthritis (specific diagnoses include ra, psa and other spa) * at time of the pdq assessment and up to 4 months thereafter being on ongoing bdmards treatment or on switch of bdmard treatment. exclusion criteria: - missing answer to pdq

Keywords: drug survival pain phenotypes paindetect questionnaire inflammatory arthritis
closurefast - radiofrequency great saphenous vein treatment

Conditions: Venous Reflux

Summary: the purpose of this study is to confirm that the closurefast system can be used as an alternative to the current closureplus catheter for treating the gsv and to accumulate pivotal data for optimization of the operating parameters.

the purpose of this study is to confirm that the closurefast system can be used as an alternative to the current closureplus catheter for treating the gsv and to accumulate pivotal data for optimization of the operating parameters. the results from this study will be used to further evaluate the risks and benefits of the closurefast device and to obtain clinical evidence that the treatment provides effective and durable clinical outcomes.

Eligibility criteria:
inclusion criteria: * age between 18 and 80 years of age at the time of enrollment * symptomatic lower limb venous disease involving the gsv exclusion criteria: * thrombosis in the vein segment to be treated * known or suspected pregnancy or actively breast feeding at time of treatment

Keywords: gsv radiofrequency
inpractice survey on the treatment of hypercholesterolemia

Conditions: Hypercholesterolemia

Summary: this is a multi-centre survey of patients who are currently on lipid-lowering pharmacological treatment. data collection for each patient will take place at one visit.


Eligibility criteria:
inclusion criteria: * subject must be 18 years of age or older of either sex. * subject is on lipid-lowering drug treatment for at least 3 months, with no dose change for a minimum of 6 weeks. exclusion criteria: * subjects who are unwilling or unable to provide informed consent.

Keywords: dyslipidemia in practice survey vietnam
load experienced while using a stander in children with cerebral palsy

Conditions: Cerebral Palsy

Summary: the goal of this project is to design and validate a force-measuring platform that will measure the magnitude and duration of the load experienced by the lower extremities of individuals with a neuromuscular disability who use a stationary assisted standing device to increase their bone mineral density.

non-ambulatory children with a neuromuscular disability are at significant risk for poor bone health as reflected by low bone mineral density (bmd) and increased propensity to fracture. in large part, this is due to abnormally low levels of load experienced by the skeleton. a common approach for increasing bmd is to stimulate the musculoskeletal system by increasing the amount and duration of weight-bearing in the lower extremities. for non-ambulatory individuals, this typically takes the form of using an assisted standing device to enable the child to spend time in a standing position so that their lower limbs can experience some degree of body weight. some of these physical interventions result in varying degrees of improvement in bmd, and some do not. this lack of clarity in outcomes may result from a failure to objectively measure the magnitude and duration of the load experienced by the lower extremities. a lack of change in bmd may be due to the extremities experiencing only a fraction of the body weight due to load-sharing with the assistive device, or to an inadequate duration of standing time. the goal of this project will be to design and validate a force-measuring platform that will measure the magnitude and duration of the load experienced by the lower extremities of individuals with a neuromuscular disability who use a stationary assisted standing device to increase their bmd.

Eligibility criteria:
inclusion criteria: 1. \< 18 years old 2. diagnosed with cerebral palsy (cp) 3. treated at gillette children's specialty healthcare 4. gross motor function classification system level of iv or v (non-ambulatory without assistance) 5. participating in a standing program using a stationary assisted standing device 6. parent/guardian willing and able to give consent exclusion criteria: none

Keywords: cerebral palsy non ambulatory neuromuscular disability children
awareness among physiotherapists about effectiveness of sensory integration therapy on cerebral palsy population.

Conditions: Cerebral Palsy (CP)

Summary: the study is to interrogate the awareness level of physiotherapists that are working in the region of khyber pakhtunkhwa, to access whether they know about sensory integration therapy or they use it for the patients of cerebral palsy in their treatment plan or not.

the study title is ''awareness among physical therapists of khyber pakhtunkhwa about the effectiveness of sensory integration therapy on cerebral palsy population.' it is a cross-sectional study that will be conducted in the province of khyber pakhtunkhwa, pakistan. the data will be conducted by 110 physical therapists on a self designed tool, that will allow us to know about the awareness among the physical therapist of this particular region to know if they are using sensory integration therapy in the treatment plan of the children suffering from cerebral palsy to know whether the sensory issues are being addressed over there by this therapy or not. another purpose of this study is to make the therapists aware about sensory integration therapy and its efficacy in treating sensory processing and sensory integration issues present in the children that are suffering from cerebral palsy. the data will be collected by the physical therapists that are currently working in various hospitals of khyber pakhtunkhwa located in different regions of the province.

Eligibility criteria:
inclusion criteria: * physical therapists working across khyber pakhtunkhwa representative of all divisions of the province. * physical therapists working as clinicians or working in healthcare vicinities from at least 2 years. exclusion criteria: * non practicing physical therapists * freshly graduated physical therapists * physical therapists working in areas other than khyber pakhtunkhwa

Keywords: cerebral palsy sensory integration therapy
the effect of breast cancer prevention journey program

Conditions: Breast Cancer Female

Summary: the aim of this quasi-experimental study is to determine the effect of the "breast cancer prevention journey program" on health beliefs about breast cancer in women over 40 years of age who have never had a mammogram before. the research aims to answer the following basic questions: -do women who participated in the "breast cancer prevention journey program" have different health beliefs about breast cancer than women who did not participate in the program? the researchers will compare the program with routine care to see if the "breast cancer prevention journey program" works. the study will be conducted in a quasi-experimental design with a pre-test post-test control group. participants in the experimental group will first participate in the "the fight against breast cancer" training structured according to the health belief model. one week after the training, the participants in the experimental group will be taken to mammography screening with free shuttles. participants in the control group will not receive any additional intervention. this group will only receive routine intervention within the scope of the breast cancer screening program conducted by the ministry of health.


Eligibility criteria:
inclusion criteria: * being a woman between the ages of 40-69 * having never had a mammogram before exclusion criteria: * being diagnosed with breast cancer * having had a breast operation

Keywords: breast neoplasms health belief model mammography
post- approval hintermann series h® study 1

Conditions: Ankle Osteoarthritis; Post-Traumatic Osteoarthritis of Ankle; Osteoarthritis of Ankle Secondary to Inflammatory Arthritis (Disorder)

Summary: the h3 tar device received u.s. food and drug administration (fda) premarket approval (pma) on june 4, 2019, and as a condition of that approval, this study is being conducted to provide long-term safety and effectiveness of the h3 tar system among patients included in the primary safety and effectiveness (pse) cohort (p1600361). this will be a prospective, single-center, single arm study.

the hintermann series h3® (h3) prosthesis is a mobile bearing total ankle replacement (tar) indicated for use as a non-cemented implant to replace a painful arthritic ankle joint due to primary osteoarthritis, post-traumatic osteoarthritis or arthritis secondary to inflammatory disease (e.g., rheumatoid arthritis, hemochromatosis, etc.). this will be a prospective, single-center, single arm study. all living subjects who participated in the pse cohort, regardless of whether or not the subject has had a revision/removal followed through the 10-year post-operation visit. 298 subjects were originally included in the pse cohort. through 10 years follow up. based on the last surgery date, it is projected the study will be completed with the final 10-year follow-up visit to occur in december 2024. patients will undergo clinical and radiographic evaluation at 5 and 10 years (+/- 90 days) post-operation. performance goals (pgs) will be constructed for the 10-year endpoint. as with the pgs used in the pma study, these will be based on a prospectively defined, systematic meta-analysis of available published literature and registry data for the control (a legally marketed mobile bearing ankle). the details of the meta-analysis will be pre-specified in a protocol for this purpose. both the protocol and the meta-analysis will be completed prior to the completion of the study.

Eligibility criteria:
inclusion criteria: * skeletally mature * primary diagnosis of osteoarthritis, post-traumatic arthritis or rheumatoid arthritis * primary total ankle replacement * unilateral or the first ankle implanted if bilateral and the surgery dates for both sides are at least 6 months apart * implanted with the correct device without screws (for investigational arm), * 3rd generation hintermann series h3 total ankle replacement; * poor pre-operative american orthopaedic foot and ankle society hindfoot score (\< 60 points) * implanted in 2013 or earlier). note that all subjects implanted in 2013 or earlier were included regardless of whether they were revised prior to the 2 year endpoint. * gave informed consent (unless irb/ethics committee waived this requirement) exclusion criteria: * prior tar or arthrodesis at the involved ankle joint
the inspire-asp uti trial

Conditions: Urinary Tract Infection (UTI)

Summary: the inspire-asp uti trial is a cluster-randomized controlled trial of hca hospitals comparing routine empiric antibiotic stewardship practices with real-time precision medicine computerized physician order entry smart prompts providing the probability that a non-critically ill adult admitted with uti is infected with a resistant pathogen. note: that enrolled "subjects" represents 59 individual hca hospitals that have been randomized.


Eligibility criteria:
facility inclusion criteria: * hca hospitals admitting adults for uti * facility use of meditech as their electronic health record system facility exclusion criteria: - note: unit of randomization is the hospital, however the cpoe alert intervention will calculate risk estimates for adults age \>=18 admitted to non-icu wards and who are ordered to receive extended-spectrum antibiotics for uti. prisoners were excluded from prompts and analysis.

Keywords: uti cpoe empiric therapy
a comparative study of ampicillin/sulbactam versus moxifloxacin in the treatment of complicated intra-abdominal infections

Conditions: Intra-abdominal Infection

Summary: on the basis of monotherapy for intra-abdominal infection, the investigators are conducting this study to identify the difference of drug efficacy between ampicillin/sulbactam and moxifloxacin.


Eligibility criteria:
inclusion criteria: * patients diagnosed of complicated intra-abdominal infection need surgical treatment exclusion criteria: * patients diagnosed of intra-abdominal infection receive non-operative management * patients with known allergic history of fluoroquinolone * severe, life threatening disease with a life expectancy of \ 35

Keywords: intra-abdominal infection moxifloxacin ampicillin/sulbactam
carcinogenicity study of bupropion

Conditions: Depressive Disorder; Cancer

Summary: there is a lack of toxicology data on one bupropion metabolite, and limited literature examining bupropion use and cancer risk. this study evaluates the association between bupropion exposure and the development of cancer of the prostate, breast, lung, colon/rectum, urinary bladder, and uterus by comparing the risk of cancer in bupropion users with other antidepressant users. because there is no evidence that bupropion is associated with any particular cancer, we have chosen the six most common cancers diagnosed in the united states to optimize statistical power/precision for cancer-site specific comparisons. two us population-based data resources with automated claims, pharmacy, and tumor registry data are included in this study. using a nested case-control design, this study will compare the incidence of cancer in patients exposed to bupropion with the incidence in patients exposed to other antidepressants.

patients were not recruited for nor enrolled in this study. this study is a retrospective observational study. data from medical records or insurance claims databases are anonymised and used to develop a patient cohort. all diagnoses and treatment are recorded in the course of routine medical practice.

Eligibility criteria:
inclusion criteria: - exclusion criteria: * cancers diagnosed within 12 months of initiation (i.e., new use) of antidepressant pharmacotherapy will be excluded to account for a minimum period for the development of cancer (cancer latency) and to be consistent with other studies of antidepressants and cancer. * patients with a history of any cancer (cancer diagnosis recorded in the tumor registries anytime before the first antidepressant prescription recorded during the study period) * any antidepressant use within 6 months of january 1, 1996

Keywords: carcinogenicity case control bupropion
the effect of exparel® on postsurgical pain, and the use of narcotics

Conditions: Rotator Cuff Tear

Summary: patients undergoing shoulder rotator cuff surgery in an outpatient setting are the focus of this study. the purpose of this study is to determine if the product exparel® can be used as a safe alternative in shoulder surgery to pain pumps, while limiting narcotic use and providing appropriate postoperative pain control.

based on prior research, it is hypothesized exparel® can potentially be used as a local anesthetic option after undergoing an arthroscopic rotator cuff repair in the outpatient setting. conducting this study, will allow the option for a surgeon to administer a local anesthetic, in a single injection, to the exact location of the surgical procedure and in a sterile environment. the purpose of this pilot study is to determine if exparel® can be used as a safe alternative to current post-operative pain control methods, while limiting narcotic use and providing appropriate postoperative analgesia.

Eligibility criteria:
inclusion criteria: * male or female * 18-72 years of age * subjects scheduled to undergo a rotator cuff repair with a subacromial decompression by one of the protocol investigators exclusion criteria: * planned concomitant glenoid labral repair * previous open shoulder surgery * neurological deficit or other disability involving the surgical extremity * anyone with a documented allergy to bupivicaine * subjects that are not mentally competent to give consent * pregnant women * subjects with an intolerance to hydrocodone or oxycodone and/or brand name equivalent combination medication

Keywords: shoulder rotator cuff
myofascial release of physiological chains and muscle stretching in patients with fibromyalgia

Conditions: Fibromyalgia

Summary: muscle stretching is a therapeutic technique commonly used by physiotherapists, but for the treatment of fibromyalgia it still has weak evidence to support its real effect. on the other hand, myofascial mobilization in the location of tender points, as it is the solution for the population, demonstrating effects on the improvement of the symptoms, but not yet achieving the minimal clinically important change. in this context, myofascial release guided by physiological chains, so far not studied, is presented as an alternative to improve pain and quality of life in patients with fibromyalgia because it acts in a global way and, probably, more effective. this study evaluates the effect of myofascial release of the trunk physiological chains and muscle stretching on pain, quality of life and functional capacity of patients with fibromyalgia when compared to the control group.


Eligibility criteria:
inclusion criteria: * confirmation of the diagnosis by rheumatologists according to the diagnostic criteria established by the american college of rheumatology of 1990 and 2010. * moderate to severe pain according to the fibromyalgia impact questionnaire (≥ 4). * prescribed treatment (drug and/or psychological) stable in the last month before the selection for those who perform. * patients who live in the metropolitan area of recife - pernambuco, brazil. exclusion criteria: * nonpharmacologic therapies, except for psychological treatment if prescribed by the doctor at the same time of the study. * skin diseases. * patients classified as "very active" by the international physical activity questionnaire. * women who use intrauterine devices (iud). * pregnant women. * patients with other associated rheumatic disease or with modified posture due to congenital anatomic alteration. * severe decompensated comorbidities (cancer, thyroid disease and diabetes). * infection, fever, hypotension, respiratory alterations limiting treatment. * cardiovascular event in the previous year. * presence of cardiac, renal or hepatic insufficiency. * arterial or peripheral venous insufficiency. * presence of a hypertrophic scar on the trunk. * obesity grade 3. * illiteracy. * severe psychiatric illness.

Keywords: myofascial release pain manual therapy muscle stretching quality of life