Kornimate/medical-research-clean huggingface dataset:
tau pet imaging with 18f-t807(av1451) in neurodegenerative disorders

Conditions: Neurodegenerative Disorders

Summary: alzheimer's disease, parkinson's disease, and huntington's disease are common neurodegenerative diseases. tau is a microtubule-associated protein, and aggregated tau resulting from hyperphosphorylation is a pathological feature of a group of neurodegenerative diseases known as tauopathies. the 18f-t807 (av1451) molecular probe is a novel molecularly targeted imaging agent that exhibits high affinity and good selectivity for tau.

in this study, 18f-t807 (av1451) molecular probe pet/ct was used to monitor the regional distribution and the degree of deposition in patients with neurodegenerative diseases, and compared with clinical symptoms to evaluate its value in the early differential diagnosis of neurodegenerative diseases.

Eligibility criteria:
inclusion criteria: * patients or their families complain of significant memory impairment; * objective memory impairment (e.g., tests of article identification, recall, delayed memory); * be able to obtain complete diagnosis and treatment records and be able to carry out long-term follow-up; * signed written consent. exclusion criteria: * psychiatric disorders: including anxiety disorder, affective disorder, severe psychosis, or drug-induced psychosis; * pregnancy or lactation.
postoperative negative-pressure incision therapy following liver transplant:a randomized controlled trial

Conditions: Liver Transplant; Complications

Summary: this study is to evaluate whether the prophylactic use of a negativa pressure therapy device (picoⓡ) on the closed wound of the liver transplant, reduces the postoperative complications of surgical wounds, compared to the use of dressings conventional postoperative

postoperative complications of surgical wounds are frequent after surgical procedures, even more in the context of liver transplantation given the necessary immunosuppression, high surgical time, high hospital stay and intensive care, politransfusions, etc. negative pressure therapy is well established for the treatment of open wounds, its use having been recently indicated on closed surgical wounds. the evidence to justify this intervention is still limited. the objective of our clinical trial is to evaluate whether the prophylactic use of a negative pressure therapy device (picoⓡ) on the closed wound of the liver transplant, reduces the postoperative complications of surgical wounds, compared to the use of dressings conventional postoperative after signing the informed consent of those patients who meet the inclusion criteria, they will be randomized into two groups to install the picoⓡ device or conventional dressings on the wound. after 7 days, the picoⓡ device will be removed and both preoperative and postoperative variables will be studied in terms of incidence of surgical site events, stay, etc.

Eligibility criteria:
inclusion criteria: * patients of both sexes aged between 18 and 70 years included in the waiting list for liver transplantation by the committee of the virgen de la arrixaca university hospital. exclusion criteria: * to have been rejected for liver transplantation by said committee

Keywords: wound complications negative-pressure wound therapy
efficacy of epidural steroid for controlling pain after primary tka

Conditions: Postoperative Pain

Summary: the purpose of this study is to determine efficacy of epidural steroid for postoperative pain control after tka

epidural triamsinolone can reduce postoperative pain and longer duration of pain control after tka

Eligibility criteria:
inclusion criteria: * osteoarthritis of the knee who undergoing unilateral primary total knee arthroplasty * 50-85 years old * asa class 1-3 exclusion criteria: * unable to perform epidural anaesthesia * history of drug allergies: lidocaine, steroid * renal impairment (crcl \<30 ml/min) * liver impairment * cognitive function disorders * displacement of epidural catheter

Keywords: post-operative pain control total knee arthroplasty epidural steroid injection
kinesiotaping versus wrist wheel on upper extremity functions in children with hemiparetic cerebral palsy

Conditions: Hemiplegic Cerebral Palsy

Summary: investigate the effect of wrist wheel exercise on rom of forearm supination and its reflection on upper extremity functions of children with hcp and compare between effects of kinesiotaping and wrist wheel on rom of forearm supination and its reflection on upper extremity functions of children with hcp

hemiparetic cp affects one side of the body, typically with marked involvement of the upper extremity, and is associated with reduced selective motor control and limited forearm supination . hemiparetic child has a significant reduction of the effective use of the arm and hand in adl (e.g. drinking, eating, accomplishing self-care, combing hair or dressing), and their participation at home, school, and later vocational roles . finding a therapeutic modality to improve rom of forearm supination is an issue of concern in this study as a child uses varying degrees of supination throughout the day to complete simple activities. some tasks only involve a person to use half of their supination rom (e.g: clapping hands together) while other activities require a person to supinate through their full rom (e.g: carrying a lunch tray). hemiparetic child has limited supination movement, therefore this study will be conducted to investigate and compare between the therapeutic outcomes of kinesiotaping and wrist wheel on rom of forearm supination which is important for upper extremity functions of the children with hcp.

Eligibility criteria:
inclusion criteria: * age ranged from six to eight years. * diagnosed as hcp. * children with mild upper limb spasticity in all upper limb muscles (grades 1 to 1+) according to modified ashworth scale. * children had impaired hand functions level ii and iii according to manual ability classification system. * they had the ability to follow simple verbal commands regarding assessment and treatment exclusion criteria: * sever visual or auditory problems * children with severe sensory at the affected upper limb. * recent orthopedic surgical interference in the affected upper limb in the last six months before the study (tenotomy or muscle transfer in the affected upper limb) * recent botulinum toxin injection of the affected upper extremity muscles in the last six months before the study.
impact of biliopancreatic limb length on diabetes following distal gastrectomy

Conditions: Stomach Neoplasm; Diabetes Mellitus, Type 2

Summary: this is a prospective, randomized controlled trial to investigate the impact of a long biliopancreatic limb of roux-en-y reconstruction on diabetes control in patients with concurrent type 2 diabetes and gastric cancer

the present study aimed to compare the changes in glucose metabolism and incretin hormone responses following long-limb bypass roux-en-y reconstruction with different biliopancreatic limb lengths after distal gastrectomy in gastric cancer patients with type 2 diabetes. this is a prospective, single-center, randomized controlled trial. patients diagnosed with stage i gastric cancer and type 2 diabetes are eligible for the present study. patients who will undergo laparoscopic distal gastrectomy for cancer located at the lower two-thirds of the stomach will only be included. the reconstruction method will be randomly assigned among long-roux limb roux-en-y (with 100 cm-long roux limb \& 50cm-long biliopancreatic limb) or long-biliopancreatic limb roux-en-y (with 50 cm-long roux limb \& 100cm-long biliopancreatic limb) reconstruction methods. all the patients are subjected to a 75g-oral glucose tolerance test (ogtt) preoperatively, and at 3 months, 6 months postoperatively, and serum glucose, as well as incretin hormones, will be serially measured. fecal samples will be obtained preoperatively and at 3 months after surgery for gut microbiota analyses.

Eligibility criteria:
inclusion criteria: * patients diagnosed with type 2 diabetes as well as pathologically proven gastric cancer of clinical stage i according to the ajcc 8th edition * those who are expected to undergo laparoscopic distal gastrectomy exclusion criteria: 1. baseline fasting c-peptide level \< 1.0 ng/dl (who had the possibility of type 1 diabetes) 2. previous radiotherapy or surgery at upper abdomen other than laparoscopic cholecystectomy 3. other malignancies in recent 5 years 4. vulnerable patients (pregnant women, those with cognitive impairment, etc) 5. ecog-ps ≥ 2 6. participating in other clinical trials within 6 months

Keywords: incretin
immature platelet fraction as a promising biomarker in prediction outcome of hellp syndrome

Conditions: Pre-Eclampsia, Severe; HELLP Syndrome; Microangiopathy

Summary: immature platelet fraction is a non-invasive test of real time thrombopoiesis. high ipf% has been suggested as an indicator of thrombocytopenia due to rapid platelet consumption. ipf% is able to discriminate between patients with ttp/hus or spe/hellp

thrombotic microangiopathy (tma) syndromes are extraordinarily diverse. thrombotic thrombocytopenic purpura (ttp) and hemolytic uremic syndrome (hus) are the two most well known, and are considered to be the most serious. ttp-hus occurs more commonly in women and among women is commonly associated with pregnancy. nevertheless, there are other pregnancy conditions that may manifest with tma, including preeclampsia, eclampsia, hellp syndrome (hemolysis, elevated liver enzymes, and low platelet count), in addition to acute fatty liver of pregnancy, antiphospholipid syndrome, and systemic lupus erythematosis. assessment of immature platelets was introduced as a non-invasive test of real time thrombopoiesis. they are newly released in the circulation with a larger size \& greater rna content than mature platelets, and can be measured by automated haematology analyzer equipped with reticulocyte detection channel and described as immature platelet fraction (%-ipf) and immature platelet count (a-ipc). a high %-ipf has been suggested as an indicator of thrombocytopenia due to rapid platelet consumption, while a low %-ipf is characteristic of bone marrow suppression states. %-ipf/a-ipf has the competency to be performed routinely and, therefore, can provide therapeutic and diagnostic feedback in the life threatening conditions. the present study aimed to show the utility of estimating %-ipf and a-ipc using a reticulocyte detection channel cbc autoanalyzer as a simple reproducible blood analysis to be employed in the differential diagnosis of pregnancy-associated thrombotic microangiopathic conditions.

Eligibility criteria:
inclusion criteria: * older than 20 years of age * pregnant with singleton intrauterine pregnancy * more than 20 weeks of gestation exclusion criteria: * congenital malformation and fetuses with chromosomal or genetic syndrome. * recent blood transfusion. * refusal to participate in the study. * bmi \<18. * placental abnormalities like velamentous insertion. * multiple pregnancies. * known kidney disease. * history of auto immune disease.
ultrasonographic evaluation of diabetic neuropathy

Conditions: Diabetic Peripheral Neuropathy

Summary: the current study aimed to evaluate the cross-sectional area (csa) of peripheral nerves in people with diabetic peripheral neuropathy using ultrasonography and correlate the csa with clinical and demographic data.

patients with diabetic peripheral neuropathy (n=53) and a matched healthy control group (n=53) underwent blinded ultrasonography imaging of the sciatic, tibial and median nerves. matching was performed according to patient body mass index (bmi), sex and age. csas of the nerves were recorded, and the associations between pain intensity (measured with a visual analog scale \[vas\]), the leeds assessment of neuropathic symptoms and signs (lanss) pain scale, diabetes mellitus duration, bmi, hba1c and blood glucose levels were evaluated.

Eligibility criteria:
inclusion criteria: * type 2 diabetes mellitus * leeds assessment of neuropathic symptoms and signs (lanss) scores ≥ 12 * probable diabetic peripheral neuropathy according to the diabetic peripheral neuropathy criteria. exclusion criteria * type 1 diabetes mellitus * hypothyroidism * lanss pain scale scores \< 12 * body mass index (bmi) \> 35 * current pregnancy * histories of hereditary neuropathy, inflammatory neuropathy, nerve trauma, or other known causes of polyneuropathy; and the use of anti-neuropathic drugs.
the effect of diane-35 pretreatment on in-vitro fertilization outcome for patients with polycystic ovary syndrome

Conditions: Polycystic Ovary Syndrome

Summary: polycystic ovary syndrome is the most common endocrine disorder in women, is estimated to affect more than 5% of the population and is associated with chronically elevated serum androgen concentrations.evidence suggests that polycystic ovary syndrome has a negative impact on pregnancy outcomes, with an increased risk of gestational diabetes, hypertensive disease during pregnancy,and preterm birth,which is partially related with the hyperandrogenic environment.diane-35 has been proved to be the most effective anti-androgenic drug.at present, there is no direct evidence that diane-35 has a positive effect on the clinical outcome of polycystic ovary syndrome patients undergoing in-vitro fertilization/intracytoplasmic sperm injection.


Eligibility criteria:
inclusion criteria: * diagnosed polycystic ovary syndrome patients according to rotterdam criteria * with hyperandrogenism and/or clinical hyperandrogenic manifestations * no other oral contraceptives treatment for at least 3 months before this experiment * no any other assisted reproductive therapy * accompanied with fallopian tube and/or male factors * normal hepato-/nephro- function exclusion criteria: * oral contraceptive pills contraindications, eg.deep venous thrombosis * smoking, drunk * exclude other infertile factors, eg.endometriosis, abnormal thyroid function, etc.
covid screening strategies in homeless shelters

Conditions: COVID-19

Summary: residents in homeless shelters will be randomized to 4 different covid-19 screening strategies with the primary outcome being covid-19 detection rate.


Eligibility criteria:
inclusion criteria: * age greater than or equal to 18 * able to provide oral consent * able to perform a self-collected swab if in the relevant intervention arm exclusion criteria: -
effect of platelet inhibition according to clopidogrel dose in patients with chronic kidney disease

Conditions: Chronic Kidney Disease; Stable Angina

Summary: impaired renal function is associated with reduced responsiveness to clopidogrel. there are no studies which have shown a means by which to overcome platelet hyporesponsiveness in patients with chronic kidney disease (ckd). the purpose of this study was to determine the functional impact of cilostazol in patients with ckd undergoing hemodialysis.

the aims of this study is to evaluate the effects of platelet responsiveness to clopidogrel or cilostazol in ckd patients undergoing hemodialysis. the differences in platelet activation markers are also evaluated before and after clopidogrel or cilostazol administration. the investigators will perform a prospective, randomized study to compare the degree of platelet inhibition and platelet activation markers by adjunctive cilostazol (100 mg twice daily) compared to clopidogrel (75 or 150 mg/day) in ckd patients undergoing hemodialysis.

Eligibility criteria:
inclusion criteria: * ckd patients undergoing chronic hemodialysis and pci for stable coronary artery disease exclusion criteria: * known allergies to aspirin, clopidogrel, or cilostazol thienopyridine use before enrollment * concomitant use of other anti-thrombotic drugs (oral anticoagulants and dipyridamole) * platelet count \<100 x 106/μl * hematocrit \< 25% * liver disease (bilirubin \> 2 mg/dl) * active bleeding or bleeding diathesis * gastrointestinal bleeding within the last 6 months * hemodynamic instability * acute coronary or cerebrovascular event within 3 months * malignancy * concomitant use of a cytochrome p450 inhibitor or a non-steroidal anti-inflammatory drug * recent treatment (\<30 days) with a glycoprotein iib/iiia antagonist.

Keywords: platelet cilostazol clopidogrel chronic kidney disease
effect on structural changes in airways, measured by msct, of twice daily 60mg azd9668 for 12 weeks in chronic obstructive pulmonary disease (copd) patients

Conditions: Chronic Obstructive Pulmonary Disease (COPD)

Summary: the primary objective of the study is to evaluate structural changes effected by ad9668 in the airways of adults with chronic obstructive pulmonary disease (copd) by multi-slice computed tomography (msct)


Eligibility criteria:
inclusion criteria: * diagnosis of copd with symptoms over 1 year * fev1/fvc \ = 40 and \< =70 % of predicted post-bronchodilator * ex-smokers for at least 12 months exclusion criteria: * past history or current evidence of clinically significant heart disease * current diagnosis of asthma * worsening of copd requiring hospitalisation and/or treatment with antibiotics and/or an increase in inhaled steroid dose and/or oral steroids within 4 weeks of study visit 1b

Keywords: chronic obstructive pulmonary lung respiratory disease efficacy placebo-controlled copd fev1 st georges respiratory questionnaire computed tomography msct
ckd report card pilot trial

Conditions: CKD

Summary: the investigators will study physician-patient communication at the ucmc nephrology fellow clinic and to test an intervention, the ckd report card, to improve that communication and patient knowledge of ckd.

the goals of the study are to 1) characterize the effectiveness and patient-centeredness of patient-physician interaction during a nephrology clinic visit both with and without use of the ckd report card, and 2) to determine which physician and patient characteristics are associated with effective and patient centered communication. there will be block enrollment. for nephrology physicians who agreed to participate will complete a baseline questionnaire. research assistants will approach patients of participating providers in clinic waiting rooms, with the goal of enrolling patients for each provider for half of the study, investigators will enroll patients in the study and observe patient-physician communication and use a survey measure ckd knowledge pre-visit and post-visit. for the second half of the study, investigators will give participants the ckd report card, an investigator-developed handout, to use during the clinic visit. investigators will observe patient-physician communication and use a survey to measure ckd knowledge pre-visit and post-visit. for both groups, eligible participants will give informed consent and will complete a baseline questionnaire; research assistants will place a digital audio-recording device in the examination room to record the patient-provider encounter. following the medical encounter, research assistants will administered an interview with patients, assessing demographic, social, and behavioral characteristics, as well as their experience of care and ratings of provider communication.

Eligibility criteria:
inclusion criteria: * english-speaking adult patients (age 18 or older) * identified in the medical record as non-hispanic black or non- hispanic white * seen in university of chicago nephrology clinic with a participating nephrologist exclusion criteria: * not able to communicate in english * lacking ability to consent to study * does not identify as non-hispanic black or non-hispanic * without chronic kidney disease
the westmead feelings program intervention for chinese children with autism spectrum disorder in hong kong

Conditions: Autism Spectrum Disorder

Summary: the goal of this intervention is to evaluate the effectiveness of delivering the westmead feelings program 2 to children with autism spectrum disorder in primary schools in hong kong.

the main questions it aims to answer are: * whether the westmead feelings program 2 hong kong version (wfp2-hk) program is effective in improving children's social-emotional skills and mental well-being. * whether the wfp2-hk program is effective in promoting parents' mental well-being child participants will receive 15 sessions of training in the wfp2-hk program. their parents and teachers will receive three training workshops by coaches or advisors. a booster session will be conducted after 5 months upon completion of the training. researchers will compare the outcome results between the treatment group and the waitlist group to see if the intervention is effective.

Eligibility criteria:
inclusion criteria: * diagnosed with autism spectrum disorder * without a diagnosis of intellectual delay * have not received any group training in emotional regulation previously exclusion criteria: * without asd diagnosis * age falls outside the age limits * with intellectual delays

Keywords: primary school social emotional competence
inventory of radiological and vestibular function in cochlear implant candidates

Conditions: Hearing Loss, Sensorineural; Bilateral Vestibular Deficiency; DFNA9; Radiology

Summary: in 2014 radiological lesions at one or more semicircular canals (scc) were described using ct \& mr imaging in subjects presenting advanced hearing and vestibular deterioration caused by the p.p51s mutation in coch. similar lesions were also described in other non-genetic advanced hearing and vestibular deterioration as well. with this prospective observational study it is the purpose to inventory imaging results of candidates for cochlear implantation which are routinely performed during the preoperative work up, since these patient present severe hearing impairment at both ears. a considerable part of them might present vestibular deterioration as well. it is the purpose to detect possible presence of these scc lesions on ct and mr in this population and the prevalence of these lesions compared to dfna9 patients.


Eligibility criteria:
inclusion criteria: * must be eligible for cochlear implantation * must be 18 years of age or older exclusion criteria: * \<18 years of age * not eligible to undergo vestibular tests, especially videonystagmography * contra-indication for mr or ct
psyco quality of life and procreation brca1/2

Conditions: Breast Cancer; Genetic Predisposition

Summary: women with breast and/or ovarian cancer or with a family history carried these pathologies can makeo genetic counseling in order to investigate whether they are carriers of the brca1/2 genetic mutation. this mutation exposes them to develop breast cancer from 50 to 80% and from 27 to 65% of developing ovarian cancer. brca1/2 mutations are inherited as an autosomal dominant manner and therefore there is a 50% probability of transmitting the mutation to the progeny. for this reason, women who have brca 1/2 mutation may be less likely to want children than those who test negative. the decision to have children could worry both for the probability to transfer the genetic mutation or because the parenthood could be compromised by the illness and/or by premature death. in previous studies, the psychological condition of patients with brca 1/2 mutations, with or without children, was only partially investigated. for this reason the main goal of the study is to deeply investigate the specific psychological condition, with particular attention to the guilt feelings on the possibility to transfer the genetic mutation to the progeny. in this wai it could be useful to development a therapeutic strategies aimed at the best adaptation of the patients to the new health condition.


Eligibility criteria:
inclusion criteria: * women with brca1/2 mutation affected or not by breast neoplasm * women with brca1/2 mutation affected or not by breast neoplasm and with at least a son/daughter * women with at list middle school diploma * women available to do interviews exclusion criteria: * women with other oncological pathology * women with cognitive deficient and/or inability to comply to the requirements of the study