Kornimate/medical-research-clean huggingface dataset:
tms for crps - pilot study

Conditions: Complex Regional Pain Syndrome (CRPS)

Summary: the purpose of this pilot study is to test whether transcranial magnetic stimulation (tms) may alleviate the symptoms of complex regional pain syndrome (crps). the investigators will test various methods of tms in a small pilot study to investigate what methods may have clinical potential. this is a small pilot study to determine feasibility and signal to potentially inform future trials.


Eligibility criteria:
inclusion criteria: 1. age 18 or older 2. diagnosis of crps (complex regional pain syndrome) 3. average pain level reported on numerical rating scale meets entry criteria 4. ability to perform the experimental task and procedures. exclusion criteria: 1. mri contraindication (metal implants or devices, claustrophobia) 2. tms contraindication (eg metal implant or devices near the site of stimulation) 3. history of epilepsy 4. history of a psychological or psychiatric disorder that would interfere with study procedures, at the discretion of the researcher. 5. neurologic illness that would interfere with brain integrity 6. current medical condition or medication use that would interfere with study procedures or data integrity, at the discretion of the researcher. 7. currently pregnant or planning to become pregnant. 8. on going legal action or disability claim.
efficacy and safety of prednisolone and chloroquine add on therapy in osteoarthritis of the knee

Conditions: Osteoarthritis of the Knee

Summary: this study was conducted to evaluate the efficacy and safety of prednisolone and chloroquine add on therapies to combined glucosamine, chondroitin sulfate in osteoarthritis of the knee which will be done in contrast to combined glucosamine sulfate and chondroitin.

fixed dose glucosamine, chondroitin sulfate combination is a treatment to osteoarthritis with some controversy about efficacy. it seems that addition of other agents may improve efficacy and decrease the required dose and cost. common oral corticosteroids such as low dose prednisolone and chloroquine are candidate for such add on therapies. nevertheless, add on therapy may expose the patients to new side effects which should followed and addressed. in this investigator blinded controlled trial, 240 patients with diagnosed osteoarthritis of knee will be enrolled to the study. the patients will randomly be assigned to one of four groups of g (glucosamine and chondroitin sulfate ), p (glucosamine and chondroitin sulfate plus prednisolone), c (glucosamine and chondroitin sulfate plus chloroquine) and pc (glucosamine and chondroitin sulfate plus prednisolone and chloroquine). each group will consist 60 patients. the investigator(s) will be blind to the groups and interventions.

Eligibility criteria:
inclusion criteria: * men and non-pregnant women, age 40-85 years with primary oa of at least one knee. exclusion criteria: * secondary arthritis related to systemic inflammatory arthritis (including rheumatoid arthritis, psoriatic arthritis, post-infectious arthritis and metabolic arthritis, traumatic arthritis or surgical joint replacement)corticosteroid use: * oral corticosteroid within the previous 14 days * intramuscular corticosteroid within 30 days * intraarticular corticosteroid into the study knee within 90 days * intra-articular corticosteroid into any other joint within 30 days or * topical corticosteroid at the site of application within 14 days * ongoing use of prohibited medication including nsaid, other oral analgesic, muscle relaxant, or low-dose antidepressant for any chronic pain management * glucosamine or chondroitin within the previous six months * history of alcohol or drug abuse * lactation * concomitant skin disease at the application site * current application for disability benefits on the basis of knee osteoarthritis; fibromyalgia; other painful or disabling condition affecting the knee

Keywords: osteoarthritis of the knee glucosamine chondroitin sulfate prednisolone chloroquine
effects of early oral feeding after resection of gastric cancer

Conditions: Gastric Cancer

Summary: the aim of this study is to determine whether early oral feeding after curative resection for gastric cancer would be tolerable and give an effect on the recovery.

most patients who undergo gastric resection for gastric cancer have maintained going on a fast of over three days after operation. surgeons have believed that early oral feeding might worsen patients' condition by prolonged postoperative ileus. therefore, patients received nothing by oral route until resolution of the ileus. however, the current trend toward minimal operative injury and early discharge from hospital. in addition, development of operative technique and instrument make the operation time to be short and the patients to be fast recovery, and thus it is possible to feed early in less than two days after operation. the aim of this study is to determine whether early oral feeding after curative resection for gastric cancer would be tolerable and give an effect on the recovery. we collect fifty-eight patients for this study and divide into two groups using randomization method. in the early feeding group, patients will receive the liquid diet two day after operation followed by soft diet postoperative three day. meanwhile, the patients who categorized into control group will start the liquid diet postoperative four day followed by soft diet postoperative six day. we evaluate the morbidity or mortality rate and laboratory findings. of course, it is supposed to be same in amount of fluid and calories between two groups.

Eligibility criteria:
inclusion criteria: patients who underwent gastrectomy for adenocarcinoma of stomach with following criteria: 1. performed curative resection 2. have the american society of anaesthesiologists (asa) score of less than 3 exclusion criteria: 1. patients who have simultaneously other cancer. 2. patients who underwent gastric resection at past time. 3. patients who have cancer with bleeding or perforation or obstruction. 4. patients who have any injury to the pancreas capsule on operation. 5. patients who get pregnancy. 6. patients who are treating diabetics with insulin.

Keywords: gastrectomy oral feeding nutrition gastric cancer
efficacy of apical preparation with passive ultrasonic irrigation in reducing intracanal bacteria

Conditions: Periapical Periodontitis; Root Canal Infection

Summary: this study evaluates intracanal bacterial load in molar teeth with chronic apical periodontitis before and after root canal shaping with two different apical enlargement sizes and ultrasonic irrigation activation.

this randomized controlled clinical trial investigated the effect of different apical enlargement sizes and passive ultrasonic irrigation (pui) on the bacterial load in the mesial roots of mandibular molars diagnosed with chronic apical periodontitis. the study was conducted at istanbul medipol university faculty of dentistry, endodontics clinic, and included 24 patients who required primary root canal treatment and exhibited clinical and radiographic signs of chronic apical periodontitis. participants were randomly assigned to two groups (n=12 each). in group 1, root canal shaping was performed using a one curve mini #25/0.4 rotary file. in group 2, shaping was performed using a one curve mini #35/0.4 rotary file. in both groups, passive ultrasonic irrigation was applied using the vdw ultra device with an irri s 21/25 ultrasonic tip. the irrigation protocol consisted of three 20-second cycles using 1 ml of 3% sodium hypochlorite (naocl) per cycle. the ultrasonic tip was positioned 2 mm short of the working length without contacting the canal walls. bacterial samples were collected from the mesial root canals during the treatment. the bacterial load was quantified using droplet digital pcr (ddpcr), a highly sensitive and precise molecular technique that allows absolute quantification of bacterial dna. this method was chosen because it enables accurate detection of bacterial reduction following the interventions.

Eligibility criteria:
inclusion criteria * a non-contributory medical history * must have an asymptomatic mandibular molar with periapical lesions of\>2.0x2.0 mm around the mesial roots * must be diagnosed as chronic apical periodontitis exclusion criteria * patients with acute clinical symptoms * teeth with previous root canal treatment * non-restorable teeth

Keywords: apical periodontitis irrigation activation apical enlargement ddpcr bacterial species
evaluation of nalmefene in impulse control disorders in parkinson's disease: a prospective open label study

Conditions: Impulse Control Disorders; Parkinson Disease

Summary: impulse control disorders (icds) (such as pathological gambling, hypersexuality, compulsive shopping ...) are an increasingly recognized psychiatric complications in parkinson's disease (pd). therapeutic management of these disorders is important since they have an impact on patient quality of life. dopamine agonists play a key role in the emergence of icd. animal models and imaging underline the implication of opioid system in the genesis of icd. an opioid antagonist, the naltrexone, has been studied to treat icds in pd. papay and al 2014 have found that patients treated by naltrexone showed an interesting decrease of their icds measured by the quip rscale. nevertheless, naltrexone has shown adverse effects such as increasing hepatic liver enzymes. nalmefene has no known hepatic adverse effects. nalmefene is an opioid antagonist that has an antagonist action on μ and δ receptors, but also an agonist action on κ receptor. grant and al 2006 has shown significant reduction of the severity of pathological gambling in patients treated with nalmefene. the primary purpose is to evaluate the efficacy and the safety of nalmefene in the treatment of icds in pd.

in this open study, 30 patients with icds, will be treated with 18 mg per day of nalmefene during 3 months. patients will be evaluated 2 times: at inclusion visit (j0) and 3 months after (at the end of the study, +3months). at each time, patients will have : * a clinical and neurological evaluation * neuropsychological tests for cognitive, depression and tci evaluations. * blood sample to test hepatic and renal functions * tolerance evaluation with a list of adverse events/effects patients will be contacted 3 times by phone: 2 weeks after inclusion, 1 month after inclusion and 2 months after inclusion, to note the presence of adverse events.

Eligibility criteria:
inclusion criteria: * patient suffering of parkinson's disease * male or female aged from 18 to 80 years old * diagnosis of icds with the ardouin scale of behavior in parkinson's disease (asbpd) with a score of at least 2 on one of the item of hyperdopaminergic symptoms * no modification of the treatments for pd since 3 months * no modification of parameters of deep brain stimulation since 6 months * patients who understood and signed the consent form * patients having a social security exclusion criteria: * contraindication to nalmefene (patients receiving opioid antalgics, antecedent of opioid dependence, dopamine agonist withdrawal syndrome, opioid consumption, patient receiving methadone or buprenorphine, severe hepatic failure, severe renal failure, antecedent of alcohol withdrawal, galactose intolerance, lactose deficit or glucose malabsorption, pregnant women) * cognitive impairment with mini mental score \< 26 * psychiatric comorbidities (bipolar disease, schizophrenia) * patient participating in another therapeutic study

Keywords: nalmefene impulse control disorders parkinson's disease tolerance efficacy
effect of hypopressive exercise versus general strengthening in postpartum women

Conditions: Postpartum Women

Summary: the aim of this study is to compare the effect of a hypopressive abdominal exercise program versus a general strengthening exercise program on inter-recti distance, abdominal and lumbar muscle thickness, lumbopelvic and abdominal pain and function, pelvic floor dysfunction, and quality of life in postpartum women. to evaluate the effects of the interventions, the subjects will be assessed at pre-intervention, immediately post-intervention and at 3-months follow-up.

the aim of this study is to compare the effect of a hypopressive abdominal exercise program versus a general strengthening exercise program on inter-recti distance, abdominal and lumbar muscle thickness, lumbopelvic and abdominal pain and function, pelvic floor dysfunction, and quality of life in postpartum women. to evaluate the effects of the hypopressive exercise, the subjects will be assessed at pre-intervention, immediately post-intervention and at 3-months follow-up. it will consist of a randomized controlled trial study. the sample will consist of women in the early postpartum period (6-8 weeks after delivery). subjects will be randomly allocated to two different exercise programs: hypopressive abdominal exercise program and general strengthening exercise program. both interventions will have a total duration of 6 weeks (18 sessions), 3 times a week, 30 minutes each session. to evaluate the effects of the interventions, the subjects will be assessed at pre-intervention (6th-8th week postpartum), immediately post-intervention (12th-14th week postpartum) and at 3-months follow-up (24th-26th week postpartum). inter-recti distance, abdominal and lumbar muscle thickness, lumbopelvic and abdominal pain and function, pelvic floor dysfunction, and quality of life will be measured.

Eligibility criteria:
inclusion criteria: * women aged between 18-45 years old * in the 6th-8th week postpartum * both vaginal or caesarean delivery * both primiparous or multiparous women exclusion criteria: * previous abdominal or pelvic surgery * reasons to suspect metabolic, neurological or neuromuscular disease * multiple birth delivery

Keywords: postpartum inter-rectus distance diastasis recti lumbar disability urinary incontinence pelvic floor quality of life
laparoscopic versus open devascularization for portal hypertension, a randomized controlled trial

Conditions: Portal Hypertension; Liver Cirrhosis

Summary: many patients with portal hypertension require surgical treatment each year,and hassab's operation, or esophagogastric devascularization and splenectomy, is an elective procedure. in recent years,laparoscopic esophagogastric devascularization and splenectomy has been used to treat portal hypertension. however, the potential benefits remain to be demonstrated in the context of a randomized trial. in this study, 120 patients will randomize equally receiving laparoscopic or open esophagogastric devascularization and splenectomy. inclusion criteria included: platelet count \< 50×109/ml, esophageal and gastric varices revealed, agreeing the informed consent. perioperativeoutcomes are: technical success, blood loose and infusion during the operation, recurrent varicose veins on gastroscopy examination, patterns of reflux on duplex ultrasound examination, complications, platelet and liver function variation, length of hospital stay. follow-up will last 5 years, and gastroscopy and ultrasonic will perform at 3 months, 1 year, 3 years, and 5 years. further more, this study was proved by the ethical committee of second hospital of xi'an jiaotong university.


Eligibility criteria:
inclusion criteria: * the cause of portal hypertension was cirrhosis * platelet count \< 50×109/ml * esophageal and gastric varices revealed * agreeing the informed consent. exclusion criteria: * thrombosis present in portal vein preoperatively * accompany with liver cancer * operation procedure is laparoscopy converse to open * patients disagree with the study.

Keywords: portal hypertension randomized clinical trial laparoscopic open
artist: arthrose intervention standardisée

Conditions: Knee Osteoarthritis

Summary: international recommendations (acr,eular) emphasize physical exercise and weight loss for patients suffering from knee osteoarthritis. nevertheless, number of patients receiving advices for these 2 points still low. this study evaluates the impact of a standardized medical intervention (patient education, weight reduction and physical exercise) in knee osteoarthritis patients.


Eligibility criteria:
inclusion criteria: * symptomatic and ambulatory patients * suffering from knee osteoarthritis (acr criteria) * 25\<bmi\<35 * signed informed consent exclusion criteria: * need to surgery within 6 next months * co-morbidity
doll therapy for agitated elderly dementia people

Conditions: Dementia; Agitation

Summary: this study is designed to determine the effect of doll therapy on the levels of agitation, nutrition, and daily living activities in elderly patients with dementia and agitation.

elderly patients with agitation and dementia incur significant costs for healthcare services. additionally, it is known that agitation can impose a burden on caregivers and has the potential to cause harm to the individual and those around them. this study is planned to determine the effect of doll therapy on the levels of agitation, nutrition, and daily living activities in elderly patients with dementia and agitation.

Eligibility criteria:
inclusion criteria: * patients with dementia * be 65 years of age or older * having met the dsm-iv standard for dementia diagnosis * having a moderate dementia diagnosis * having a severe dementia diagnosis * having enough manual skills to hold and care for the doll * visual acuity is sufficient to recognize the doll * there is no communication problem * volunteered to participate in the research * to have the consent of the relatives patients to participate in the research. exclusion criteria: * having a mild dementia diagnosis * the presence of systemic disease in the period of acute exacerbation * who has a psychological disorder * elderly people who experienced difficulties after two attempts in accepting a baby and forming a relationship * elderly people who left the doll after a while despite accepting it * elderly people who stated that dolls have a bad connotation in themselves.

Keywords: dementia doll therapy nursing daily activity nutrition
distal protection device in st-elevation myocardial infarction (stemi)

Conditions: ST-segment Elevation Myocardial Infarction

Summary: the investigators examined the mechanism underlying the lack of benefit from distal protection and thrombus aspiration (dp-ta) in 126 patients with st-elevation myocardial infarction (stemi) in a prospective, randomized trial.

patients with first-diagnosed stemi were randomly assigned to distal protection and thrombus aspiration (dp-ta) pretreatment during percutaneous coronary intervention (pci) or conventional pci (c-pci). the primary endpoint was the remodeling index (ri), measured by cardiac magnetic resonance imaging (cmr) post-pci and 6 months after pci. secondary endpoints, determined by cmr within 3 to 5 days after pci, included the infarct ratio (infarct size to entire left ventricular \[lv\] size ) by delayed-enhancement (de), area at risk (aar) ratio (aar to lv size) by t2 high-signal intensity , microvascular occlusion index (mvo) ratio (mvo to lv size) by de, and myocardial salvage index (msi, \[aar-infarct size\] x 100/aar).

Eligibility criteria:
inclusion criteria: * 30 and less than 80 years presenting with stemi * more than 30 minutes but less than 12 hours after symptom onset * with ≥ 2 mm of st-segment elevation in 2 or more contiguous leads or with a presumably new left bundle-branch block * for whom primary pci was intended exclusion criteria: * included thrombolytic therapy before pci; * spontaneous restoration of coronary flow (\> timi grade ii or iii); * cardiogenic shock (killip class iv); * major surgery or active bleeding within 6 weeks; * aspirin, thienopyridine, or heparin allergy; * neutropenia (\ 2.5 mg/dl \[221 μmol/l\]); * noncardiac condition with expected survival less than 1 year; * current participation in other investigations.

Keywords: st-elevation myocardial infarction percutaneous coronary intervention cardiac magnetic resonance imaging microvascular occlusion myocardial salvage
studying biomarkers in tumor tissue and blood samples from patients with small cell lung cancer registered on calgb-140202

Conditions: Lung Cancer

Summary: rationale: studying samples of tumor tissue and blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in dna and identify biomarkers related to cancer. purpose: this research study is studying biomarkers in tumor tissue and blood samples from patients with small cell lung cancer registered on calgb-140202.

objectives: primary * to identify the major genetic alterations in human small cell lung cancer (sclc) using next-generation sequencing and focusing on mutations in coding sequence. secondary * to follow up with in-depth assessment of candidate oncogenes and tumor suppressor genes using gene expression analysis, cell culture systems, and murine models of sclc. outline: dna isolated from archived tumor tissue and blood samples are analyzed for genetic mutations and gene expression profiling using illumina exome sequencing. results are compared with transcriptome of tumors (or cell lines) with and without the specific mutation. cell culture studies overexpressing or inhibiting the genes of interest are also performed in a mouse model to identified potential drivers of small cell lung cancer.

Eligibility criteria:
* patients must have been registered to calgb-140202 trial in which tumor material (frozen tissue and paired blood specimens) is available * institutional review board (irb) review and approval at the institution where the laboratory work will be performed is required

Keywords: small cell lung cancer
low dose anti-inflammatory radiotherapy for the treatment of pneumonia by covid-19

Conditions: Pneumonia, Viral

Summary: low radiation doses produce anti-inflammatory effects, which may be useful in the treatment of respiratory complications of covid-19. this type of treatment is non-invasive and therefore, a priori, it can be used in all types of patients. main objective: to evaluate the efficacy of low-dose lung irradiation as an adjunctive treatment in interstitial pneumonia in patients with covid-19 by improving the pafi o2 by 20% measured 48h after treatment with respect to the pre baseline measurement. -irradiation.

study design: this is a prospective multicenter study in 2 phases: 1. exploratory phase. it will include 10 patients, to assess the feasibility and efficacy of low-dose lung irradiation. if a minimum efficiency of 30% is not achieved, the study will not be continued. 2. comparative phase in two groups, a control group, which will only receive pharmacological treatment, and an experimental one. it will include 96 patients, the allocation will be 1: 2, that is, 32 in the control arm and 64 in the experimental arm, which will receive low-dose lung irradiation.

Eligibility criteria:
inclusion criteria: * age \>=18 years old * moderate to severe covid-19 pneumonia with fewer than 8 days of symptom onset and currently receiving standard medication for covid-19 at appropriate doses * pafio2 of less than 300 mmhg or safi02 \<315 mmhg * patients who are not candidates for admission to the intensive care unit due to age, concomitant diseases or general condition. * one of the following conditions: * or il6 greater than 40 * or pcr\> 100mg / l * d-dimer greater than 1500ng / ml * suspected cytokine release syndrome * have read the information sheet and signed the informed consent exclusion criteria: * age \<18 years * failure to meet the inclusion criteria * leukopenia \<1000 * pregnancy * not understanding or refusing the purpose of the study

Keywords: covid 19 radiation anti-inflammatory effects