Kornimate/medical-research-clean huggingface dataset:
protocol for the infusion of buffy coat-derived cryopreserved platelets in patients with severe thrombocytopenia

Conditions: Thrombocytopenia; Primary Thrombocytopenia,Unspecified; Thrombocytopenia Chemotherapy Induced

Summary: the increasing need for blood components and the increasingly careful donor selection procedures, make the availability of blood components very reduced, in particular for platelets that are currently administered preferably "fresh" or cryopreserved, only in emergency conditions. exceeding this limit through the spread of use of cryopreserved platelets in the common clinical practice, might help clinicians to avoid wasting valuable products and face periods of particular shortage of donors some studies already published in the literature over the last decade (1,2) have demonstrated the safety and efficacy of autologous cryopreserved platelets . the main objective of the proposed study is to evaluate the efficacy and safety of platelets, cryopreserved with dmso using a a new method, in patients with severe thrombocytopenia. this is the in vivo phase of a study where availability and efficacy of cryopreserved platelets has been assessed in vitro.

the primary objective of the study is to evaluate the hemostatic efficacy and safety in the recipients of platelets obtained from buffy coat of multiple donors (five), cryopreserved with dmso using a new patented method, up to 9 months from the collection. further goals are the registration of any related- adverse event (idiosyncrasy, allergy, toxicity)

Eligibility criteria:
inclusion criteria: cryopreserved buffy coat pooled platelets will be infused, after being thawed, in inpatients at u.o. of hematology -policlinic "p. giaccone"-palermo, falling into one of the following categories: * stable clinical conditions and no complications with platelets ≤ 10,000/microliter; * with active bleeding and ≤ 20,000 platelets/microliter; * in the presence of: high blood pressure, high fever, rapid drop in platelets, infection, chemotherapy, coagulation abnormalities with ≤ 20,000 platelets/microliter. exclusion criteria: patients * suffering from congenital immunodeficiency * allogeneic bone marrow transplant candidates * bone marrow donors for transplantation * undergoing bone marrow transplant or * suffering from hodgkin's disease and treated with purine analogues (fludarabine, cladribine)

Keywords: cryopreserved platelets, thrombocytopenia, dmso
ultrasound image fusion for placement of sacral quadripolar leads

Conditions: Urinary Incontinence

Summary: determine the ability of real-time ultrasound with fusion technology of prior acquired mri of the pelvis to guide a needle to the second sacral foramen using the posterior approach and place a interstim lead.


Eligibility criteria:
inclusion criteria: * patient consented for interstim lead placement exclusion criteria: * patients requesting not to be in the study. * pregnant patients

Keywords: urinary incontinence
efficacy of the wavefront optimized (wfo) profile in non-anterior astigmatisms

Conditions: Astigmatism

Summary: the purpose of the study was to assess the efficacy of the allegretto wave excimer laser and the wavefront optimized ablation profile in correcting primarily non-anterior astigmatism faults, following laser in-situ keratomileusis (lasik) and photorefractive keratectomy (prk).

different optical components of the eye contribute to the total astigmatism error.in specific, the anterior corneal surface is responsible for the anterior component of astigmatism fault (anterior astigmatism), while the posterior corneal surface and the lens are responsible for the posterior one (posterior astigmatism). regarding our study, 74 refractive surgery candidates were recruited. only one eye from each candidate was randomly enrolled in the study. of them, 40 eyes underwent lasik treatment (lg group), while 34 eyes underwent prk treatment (pg group). the allegretto wave excimer laser (software version: 2.020 / wavelight ag, erlangen, germany) was used for the ablation in all groups. preoperatively, the ocular residual astigmatism (ora) was calculated for each eye, according to which each astigmatism fault was characterized as primarily anterior or non-anterior.ora is the vectorial value of astigmatism arising from non-anterior sources. its amount on total astigmatism (r) is determined by the magnitude ratio ora/r. ratios below 1 indicate primarily anterior astigmatism, while ratios above 1 indicate primarily non-anterior astigmatism. 20 lg eyes and 16 pg eyes presented primarily anterior astigmatism (lg-a and pg-a subgroups, respectively), while 20 lg eyes and 18 pg eyes demonstrated primarily non-anterior astigmatism (lg-na and pg-na subgroups, respectively). postoperatively, vector analysis of astigmatism correction was conducted; the following indexes were calculated: a) correction index (ci), b) difference vector (dv) and c) index of success (ios).

Eligibility criteria:
inclusion criteria: * astigmatism fault exclusion criteria: * previous incisional eye surgery * evidence of any type of corneal pathology * evidence of any type of optic neuropathy * history of optic neuropathy * diabetes mellitus

Keywords: non-anterior astigmatism correction allegretto wave excimer laser wavefront optimized ablation profile (wfo) lasik prk
proprioceptive exercises on joint pain and qol among geriatric patients with knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: knee osteoarthritis, the disease of knee joint pain caused by joint degeneration, it is the commonest joint disease and had a negative effect on geriatric patients' quality of life (qol). proprioceptive exercise and isometric exercise have been recommended as suitable for reducing joint pain and improvement of quality of life in the geriatric patients.

knee osteoarthritis (oa), known as degenerative joint disease of the knee. it is most common in the geriatric and is typically the result of wear and tear and progressive loss of articular cartilage. it happens when cartilage in knee joint breaks down. when this happens, the bones in knee joint rub together, causing friction that makes knees hurt, become stiff or swell. knee oa is a painful condition and causes exhaustion in affected patients. patients with this illness often complain of pain, decreased muscle strength, and joint instability. in addition, increased pain in knee oa patients also progressively worsen their quality-of-life. proprioceptive activity in patients with knee oa gets limited or reduced and leads to reduced activities of daily living (adls). joint proprioception is the ability of an individual to sense the joint position and movement. it encompasses the joint motion and joint position so proprioceptive exercises are being used for the strengthening of muscles around the knee joint. thus, proprioceptive exercises are recommended exercise which significantly improved pain in knee oa patients which as results lead to improve quality of life. quadriceps strengthening has been an important component of exercise program of knee osteoarthritis. this is because quadriceps weakness is the most presented finding among people with knee osteoarthritis. an isometric exercise is a form of exercise involving the static contraction of a muscle without any visible movement in the angle of the joint which lead to reduce joint pain and improving qol in geriatric patients with knee osteoarthritis. the study sample (70) geriatric patients received proprioceptive exercises only, while the control group (70) geriatric patients received routine exercise (isometric exercise) only.

Eligibility criteria:
inclusion criteria: * geriatric patients aged 60 years and above diagnosed with knee oa. * male and female geriatric patients. * alert and able to communicate. * mild and moderate knee oa (based on x-rays) exclusion criteria: * patients with advanced knee oa. * patients with end stage organ failure. * patients with cognitive impairment who will not be able to take active part in the study. * patients with neurological impairment or physical disability that interfere with their participation in the study. * patients with uncontrolled medical conditions.
the effect of intranasal vasoconstrictor medications on hemodynamic parameters: a randomized double-blind, placebo-controlled trial.

Conditions: Epistaxis; Blood Pressure

Summary: nosebleeds (epistaxis) are a frequent cause of emergency department visits, reportedly inciting 1 in 200 visits. they are most common in those less than ten and older than seventy, often occurring in the winter months secondary to dry indoor heating. epistaxis is associated with elevated blood pressures, but it is controversial whether hypertension is actual a contributing cause. in non-life-threatening epistaxis, the first step in management is commonly the application of a topical vasoconstrictive medication. in many cases this will lead to cessation of the bleeding or facilitate the exam in those that continue to bleed. frequently used medications include phenylephrine, oxymetazoline, and lidocaine with epinephrine. classic teaching has been to avoid the use of these medications in patients with elevated blood pressures due to concerns of inducing hypertensive crisis. strict avoidance of topical vasoconstrictors in this patient group with epistaxis severely limits the treatment options for a many patients given the association between the two conditions. though universally taught, the actual effect of these agents on blood pressure remains unquantified. studies investigating the prevention of nose bleeding during nasotracheal intubations suggest that the effect might be minor with little variation between agents. clinical question: what is the effect of commonly used intranasal vasoconstrictors on blood pressure in volunteers without a history of hypertension.


Eligibility criteria:
inclusion criteria: * healthy volunteers over the age of eighteen that have been recently dismissed from the emergency department at mayo clinic hospital, saint marys campus. * we will recruit a convenience sample of 100 patients from the emergency department who have completed their emergency department evaluation and treatment and are being discharged to home with non-painful conditions. exclusion criteria: * we will exclude persons under the age of eighteen * vulnerable populations (pregnant patients and prisoners) * those with an allergy to any of the study agents * those with acute pain * those using antihypertensive or antiarrhythmic agents * those with significant cardiopulmonary comorbidities (namely history of arrhythmia, coronary artery disease, hypertension, and heart failure) * those with concomitant use of monoamine oxidase a (mao) inhibitors * those with a diagnosis of angle closure glaucoma or benign prostatic hyperplasia (bph) * those with a history of cerebrovascular disease * as well as those with a history of previous nasal surgery or known nasal anatomic abnormalities.
vonoprazan-containing triple therapy versus empiric bismuth quadruple therapy for first-line helicobacter pylori treatment: a randomized clinical trial

Conditions: Helicobacter Pylori Infection

Summary: vonoprazan amoxicillin and metronidazole based triple therapy had achieved a high cure rate in the rescue treatment of helicobacter pylori infection. this study aims to evaluate the efficacy and safety of the vonoprazan, amoxicillin and metronidazole based triple therapy and the empiric bismuth quadruple therapy in the naive patients with helicobacter pylori infection.


Eligibility criteria:
inclusion criteria: * participants with non-ulcer functional dyspepsia or peptic ulcer disease * ability and willingness to participate in the study and to sign and give informed consent * confirmed h. pylori infection and with no previous treatment experience exclusion criteria: * less than 18 years old * with previous gastric surgery * major systemic diseases * pregnancy or lactation * allergy to any of the study drugs administration of antibiotics, bismuth, antisecretory drugs in 8 weeks prior to inclusion

Keywords: helicobacter pylori infection
dexamethasone with ropivacaine for peng block in total hip arthroplasty

Conditions: Hip Osteoarthritis; Hip Pain Chronic; Hip Arthritis

Summary: does adding dexamethasone to the periarticular nerve group block in patients undergoing total hip arthroplasty reduce the dose of ropivacaine?

hip arthroplasty is one of the most common orthopaedic procedures, especially in elderly patients, due to the deformation of joints. patients may complain of severe pain due to surgical trauma and prostheses. regional anaesthesia methods may be performed to reduce the inflammatory response, opioid consumption, and opioid-related side effects.

Eligibility criteria:
inclusion criteria: * patients scheduled for total hip arthroplasty * patients aged \>65 and \<100 years * patients able to provide informed consent * patients able to reliably report symptoms to the research team exclusion criteria: * inability to provide first-party consent due to cognitive impairment or a language barrier
effects of respiratory muscle training in patients with acute ischemic stroke

Conditions: Stroke, Ischemic

Summary: after acute ischemic stroke, the muscle strength of the limbs of the patients will decrease. moreover, the respiratory muscles may also be affected. the respiratory muscle training may improve the respiratory recovery and prevent pulmonary complication.

after acute ischemic stroke, the muscle strength of the limbs of the patients will decrease. moreover, the respiratory muscles may also be affected. the worsening of the respiratory function is weakened and lung function declines, leading to dysfunction of expectoration and swallowing, and increasing the incidence of pneumonia after stroke. in addition, it will also lead to a decline in activity ability, which in turn affects the quality of life. the respiratory muscle training may improve the respiratory recovery and prevent pulmonary complication.

Eligibility criteria:
inclusion criteria: 1. ischemic stroke diagnosed by mri 2. age over 20 years old 3. no worsening of stroke or second stroke this time exclusion criteria: 1. unable to understand instructions normally, or communication difficulties 2. patients with endotracheal tube or tracheostomy 3. angina in recent 3 months, myocardial infarction, heart failure 4. patients with asthma or chronic obstructive pulmonary disease, spontaneous pneumothorax, and ongoing pneumonia 5. patients with untreated hernias 6. pregnant 7. ongoing fever (body temperature\>38.5°c) 8. poor hypertension control (higher than 170/100 mmhg three days before intervention) 9. patients who have had cerebral hemorrhage or aneurysm

Keywords: stroke respiratory muscle training respiratory function
contribution of stereography (eos imaging system) in the quantification of femoral shaft fractures.

Conditions: Femoral Shaft Fracture

Summary: this observational study is a collection of clinical and imaging data of patients with a femoral shaft fracture treated by nails. the aim of this research is the contribution of the eos imaging system in the quantification of malunions.

the study is based on the collection of clinical and imaging data (using eos imaging system) necessary for the follow-up of patients who have benefited, most often in the emergency, of a centromedullary nailing of the femoral shaft. the study does not lead to any further examination for the patient since they are followed until the removal of the material, which usually takes place 24 months after the fracture episode. this observational and pilot study is monocentric, prospective on a continuous series of 40 patients.

Eligibility criteria:
inclusion criteria: * patients aged at least 16 years (parental agreement signed for minors) or adults at the time of data collection * patients with a femoral shaft fractures since january 2014 * patients with a post-nailing femoral shaft fracture * patients with unilateral fracture * patients with regional origin allowing a follow-up in grenoble center exclusion criteria: * patients who refuse to sign a non-objective form * patients with femoral shaft fracture untreted with nails

Keywords: eos imaging stereography centromedullary nailing quantification of malunions
registry of cell therapy in non-ischemic dilated cardiomyopathy

Conditions: Cardiomyopathy, Dilated

Summary: although several studies have demonstrated beneficial effects of stem cell therapy in patients with non-ischemic dilated cardiomyopathy, the long term benefits and predictors of response to therapy remain undefined. the aim of this registry is to pool long-term clinical data in patients with non-ischemic dilated cardiomyopathy undergoing autologous cell therapy in an attempt to better define predictors of response to such treatment.

registry will include all patients who underwent intracoronary or intramyocardial cell therapy as a part of clinical trials performed at umc ljubljana from january 2005 until january 2018. patients will be followed on regular basis in a dedicated heart failure outpatient clinic, clinical data will be collected and stored in a secure central database. data will be analyzed in periodic intervals by an independent data monitoring board in an attempt to better define the predictors of clinical response to cell therapy in this patient population.

Eligibility criteria:
inclusion criteria: * patient inclusion criteria consisted of the following: age 18-65 years old, diagnosis of dcm according to the european society of cardiology position statement (9), optimal medical management for at least 6 months, left ventricular ejection fraction (lvef) \<40%, and new york heart association functional class iii on stable medical therapy for at least 3 months before referral. exclusion criteria: * patients with acute multi-organ failure or a history of hematologic neoplasms were not included.

Keywords: cell therapy
adductor canal block in outpatient clinic for pain control after knee arthroplasty

Conditions: Acute Pain; Total Knee Arthroplasty

Summary: single-shot adductor canal block in the outpatient clinic is safe, significantly decreased pain and analgesic consumption and may enhance the rehabilitation program

the acb in the outpatient clinic is safe and can minimize postoperative pain. the primary goal of this research was to see how acb affected the visual analog score (vas) pain score during the rehabilitation as opposed to controls. the secondary goal was to determine how much analgesic (etoricoxibe) was consumed on a daily basis.

Eligibility criteria:
inclusion criteria: * indonesian or javanese-speaking adults * after perfomed total knee replacement * american society of anesthesiologists physical status i-iii * body mass index (bmi) of 18-40 kg/m2 exclusion criteria: * declined to complete the study * unable to cooperate * had an allergic reaction to any of the drugs * abusing alcohol or drugs
hit in insulin-resistant and insulin-sensitive obese adolescents

Conditions: Obesity; Insulin-resistant; Adolescents

Summary: evaluate the effects of hit on the cardiorespiratory performance and substrate oxidation of insulin-resistant and insulin-sensitive obese adolescents.

objective: to evaluate the effect of high-intensity interval training (hit) on the cardiorespiratory performance and substrate oxidation pattern in insulin-resistant and insulin-sensitive obese adolescents.

Eligibility criteria:
criteria inclusion criteria: * aged 12-16 years * with a body mass index z-score (zbmi) ≥ + 2sd * puberty stage \> 3 * the boys and girls had to present a minimum physical fitness, according to the international physical activity questionnaire (ipaq), according to the activity performed during the last week and confirmed this using the peak cardiopulmonary test (vo2). exclusion criteria: * individuals undergoing drug treatment for weight control; * indiviudals who had cardiac, orthopedic, respiratory or renal problems, diabetes, uncontrolled hypertension, genetic syndrome or hormonal abnormalities.

Keywords: obesity insulin-resistant adolescents high-intensity interval training
is the measured diameter of the optic nerve sheath by cerebral scan in patients with early-phase meningeal hemorrhage, due to a ruptured aneurysm, a prognostic 6-month mortality factor ?

Conditions: Subarachnoid Hemorrhage

Summary: sub arachnoid hemorrhage (sah) is a public health concern because of its high incidence (7/100 000 inhab.), its mortality rate (25%), and its morbidity rate (50%).

sub arachnoid hemorrhage (sah) is a public health concern because of its high incidence (7/100 000 inhab.), its mortality rate (25%), and its morbidity rate (50%). prognostic tools are indispensable in guiding and optimizing the care of these patients. some diagnostic factors have been identified (e.g. age, comorbidities, acsos , gcs, icp, occurrence of complications) as well as some classification schemes used for grading seriousness of the disease (hunt and hess, world federation of neurosurgery). a tool that is simple, reliable, reproducible, non costly, non invasive, and simple to perform (including remote methods and without changing planned patient care) would be ideal. the measurement of the optic nerve sheath diameter (onsd,) correlated by mri and ultrasound in previous studies, with intra-cranial pressure (icp: a fundamental prognostic factor for sah) could be one of these tools. this measurement, previously demonstrated using ultrasound, could be carried out at the time of the patient's initial cerebral scan. in practice, at admission each patient undergoes a cerebral ct scan much more often than an ultrasound (faster, less costly, less technical training required). two preliminary studies seem to suggest that this measurement of onsd on ctc is a predictive factor for morbi-morbidity in patients having serious traumatic skull fractures.the measurement is reliable, reproducible, non invasive, and non costly, with good sensitivity and specificity. proving that it is also applicable to sah could be particularly useful.

Eligibility criteria:
inclusion criteria: * patients 18 years or older * patient admitted to the neurosurgical urgent care unit for sah following a ruptured aneurysm * patients or one of their loved ones providing written informed consent * patients with healthcare coverage exclusion criteria: * unavailability of a ctc in the initial phase (within the first 12 hours) or absence of 1-mm slices from the scan * trauma to the optic globe or optic nerve pathology * preexisting anomalies of icp or history of neurosurgical cerebral pathologies * sah of non aneurysm origin (e.g. arterio-venous malformation (avm), tumor, trauma, sepsis) * patients under legal protection

Keywords: optic nerve sheath meningeal hemorrhage early phase prognostic