Kornimate/medical-research-clean huggingface dataset:
pneumatic retinopexy versus vitrectomy for retinal detachment

Conditions: Rhegmatogenous Retinal Detachment

Summary: the purpose of this research study is to compare the outcomes of pneumatic retinopexy with the outcomes of vitrectomy (with or without scleral buckle) for the management of retinal detachment, in terms of anatomical success, functional success and impact on patient quality of life.

rhegmatogenous retinal detachment (rrd)is an acute, sight threatening condition, with an incidence of approximately 10 per 100,000 population. both of the treatments under investigation are widely used and accepted by vitreoretinal surgeons, but randomised, prospective comparison of the two techniques has not been reported in the scientific literature to date. currently, the management decisions surrounding primary retinal detachment are grounded on a weak evidence base. the findings of this study will allow vitreoretinal surgeons and their patients to select the most appropriate intervention for that individual, in an informed and holistic manner.

Eligibility criteria:
inclusion criteria: * patients presenting with acute rhegmatogenous retinal detachment * single retinal break or group of breaks no larger than one clock hour (30°) * all break/s in detached retina between 8-4 o'clock * no significant proliferative vitreoretinopathy exclusion criteria: * inferior breaks in detached retina * inability to read english language * age \< 18 years * mental incapacity * previous vitrectomy (index eye) * previous retinal detachment (index eye) * inability to maintain the post-operative posturing * inability to carry out detailed examination of peripheral retina due to media opacity

Keywords: retinal detachment pneumatic retinopexy vitrectomy
study of topical ocular pan-90806 in pdr

Conditions: Diabetic Retinopathy

Summary: the objective of this study is to assess the safety and tolerability of topical ocular pan-90806 in patients with proliferative diabetic retinopathy.


Eligibility criteria:
inclusion criteria: * aged 18 years or older with type 1 or type 2 diabetes * proliferative diabetic retinopathy (pdr) in study eye retina with or without diabetic macular edema (dme) involving the center of the macula * demonstrate the ability, or have a family member who is willing and able, to instill topical ocular drops in the study eye exclusion criteria: * current or recent use (within the last 3 months) of anti-vascular endothelial growth factors (anti-vegf) in either eye; * uncontrolled hypertension despite use of antihypertensive medications * unwillingness to refrain from wearing contact lenses for the duration of the study. * participation in any investigational drug or device study, systemic or ocular, within past 3 months * women who are pregnant or nursing * known serious allergies or hypersensitivity to the fluorescein dye used in angiography or to the components of the pan-90806 formulation

Keywords: proliferative diabetic retinopathy
dietary patterns and cardiovascular (cvd) risk in spinal cord injury (sci) factors in individuals with chronic spinal cord injury

Conditions: Spinal Cord Injury

Summary: this study will look at dietary patterns in individuals with chronic spinal cord injuries and the relationship between these dietary patterns and cardiovascular disease risk factors. the study is a supplement to the coronary artery risk development in young adults (cardia) study. the dietary history from cardia will be used. the investigators' primary hypothesis is the following: greater whole-grain and dietary fiber intake will be favorably associated with adiposity (bmi and wc) and metabolic cvd risk factors (fasting glucose, fasting insulin, homa-ir, diabetes, hscrp, tc, hdl-c, triglycerides, tc/hdl-c ratio, non-hdl-c, and systolic and diastolic blood-pressure) among a sample of individuals with sci aged 38-50 who have been injured \>1 year.

this study is a cross-sectional study. it will look at dietary patterns in individuals with chronic spinal cord injuries and the relationship between these dietary patterns and cardiovascular disease risk factors. the study is a supplement to the coronary artery risk development in young adults (cardia) study. the dietary history from cardia will be used. the investigators' primary hypothesis is the following: greater whole-grain and dietary fiber intake will be favorably associated with adiposity (bmi and wc) and metabolic cvd risk factors (fasting glucose, fasting insulin, homa-ir, diabetes, hscrp, tc, hdl-c, triglycerides, tc/hdl-c ratio, non-hdl-c, and systolic and diastolic blood-pressure) among a sample of individuals with sci aged 38-50 who have been injured \>1 year.

Eligibility criteria:
inclusion criteria * male or female, black or white with sci due to a nonvascular insult that caused an acute spinal cord injury (i.e. traumatic injury, transverse myelitis without a diagnosis of multiple sclerosis, surgical complication, or benign neoplasm) at least 1 year prior to enrollment including asia a,b,c * age at time of enrollment: \> 38 years and \<55 years (i.e., on or after 38th birthday and before 55th birthday) * voluntary, informed consent of participant * participant willing to comply with the testing protocols and questionnaires * communication and comprehension sufficient for compliance with all testing procedures and measures exclusion criteria * sci of a vascular or malignant etiology * pregnancy, end-stage renal disease, treatment for cancer except for non-melanoma skin cancer in the past five years * injury \< 1 years prior to enrollment * asia d * chronic, nontobacco substance-abuse

Keywords: spinal cord injury cardiovascular disease dietary patterns
lavender aromatherapy spine procedure study

Conditions: Spine Injuries and Disorders; Pain, Back

Summary: patient anxiety prior to invasive procedures poses a significant barrier to successful treatment if not well-managed. the purpose of this study is to evaluate lavender aromatherapy, a non-sedating alternative, to reduce anxiety prior to interventional spinal procedures.


Eligibility criteria:
inclusion criteria: 1. males and females between 18-85 years old 2. scheduled for one of the following procedures on the day of consent: 1. epidural steroid injection (esi) 2. medial branch block (mbb) 3. radiofrequency ablation (rfa) 3. able to provide informed consent exclusion criteria: 1. history of anxiety disorder 2. currently on anxiolytic therapy 3. poor sense of smell 4. allergy/aversion to aromatherapy 5. non-english speaking

Keywords: aromatherapy lavender anxiety spine intervention
dynamic changes of torquetenovirus (ttv) load in chinese renal transplant recipients

Conditions: Kidney Transplant Rejection; Kidney Transplant Infection; Virus; Immunosuppression

Summary: the goal of this observational study is to learn about dynamic changes of torquetenovirus (ttv) load in chinese renal transplant recipients. the main questions it aims to answer are: * is there correlation between ttv load and rejection? * is there correlation between ttv load and infection? * can changes in the ttv load of kidney transplant recipients predict rejection or infection? participants will: * receive 13 follow-up visits within 1 year after kidney transplantation * provide 2 ml of whole blood for ttv load testing and other related testing at each follow-up * provide 10 ml of whole blood for dd-cfdna testing at four follow-ups (1, 3, 6 and 12 months after transplantation) * provide 1 ml of serum for donor-specific antibody testing at three follow-ups (1, 6 and 12 months after transplantation)


Eligibility criteria:
inclusion criteria: * receiving abo compatible renal allotransplantation from the initiation of the study to december 31, 2023 * receiving tacrolimus /mycophenolate mofetil(or mycophenolic acid)/prednisone as maintenance immunosuppression after renal transplantation * receiving universal prophylaxis for cmv infection and pjp infection exclusion criteria: * receiving combined liver-kidney, pancreas-kidney or heart-kidney transplantation * recipients with active hepatitis b or hepatitis c infection * recipients with anticipated irregular follow-up

Keywords: kidney transplantation rejection infection donor specific antibodies cell-free dna torque teno virus immuno-monitoring
12 / 48 wk pivotal pft vs pbo in copd ii

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: this primary objective of this study is to compare two doses of bi 1744 cl inhalation solution delivered by the respimat® inhaler once daily to placebo in patients with chronic obstructive pulmonary disease (copd).


Eligibility criteria:
inclusion criteria: * all patients must have a diagnosis of chronic obstructive pulmonary disease * male or female patients, 40 years of age or older patients must be current or ex-smokers with a smoking history of more than 10 pack years post bronchodilator fev1 \<80% predicted and post-bronchodilator fev1/fvc \<70% exclusion criteria: * patients with a significant disease other than copd * patients with a history of asthma * patients with any of the following conditions: a history of myocardial infarction within 1 year of screening visit (visit 1) unstable or life-threatening cardiac arrhythmia. have been hospitalized for heart failure within the past year. known active tuberculosis a malignancy for which patient has undergone resection, radiation therapy or chemotherapy within last five years (patients with treated basal cell carcinoma are allowed) a history of life-threatening pulmonary obstruction a history of cystic fibrosis
musculoskeletal changes after physiotherapeutic intervention in podiatric subjects

Conditions: Prevention of Diabetic Foot

Summary: the recurrence of diabetic foot ulcers (dfu) is a key problem in podiatric care. it is very often given by biomechanical abnormalities frequently present in those patients. the aim of our randomized controlled study is to find possible changes as of plantar pressures as of biomechanics of the ankle and small joints in patients with type 2 diabetes mellitus with different degrees of neuropathy. during this project, investigators will examine the possible impact of 12-week lasting intervention program on the distribution of plantar pressures, joint mobility and muscle strength of lower limbs. the incidence of ulcerations / reulcerations and changes of psychosocial characteristics will be evaluated during the study period. approximately 60 patients with type 2 diabetes mellitus will be included into the study. these patients will be randomized into 3 study groups - patients with type 2 dm with mild form of peripheral sensory neuropathy (20 subjects), patient with severe peripheral neuropathy (20 subjects) and those with diabetic foot syndrome, without active lesion (20 subjects). all patients will undergo 12 week lasting active intervention program consisting of recommendations by a physiotherapist focusing on the improvement of physical fitness, muscle strength and foot joint improvement. control group will be consisted of 20 patients with healed diabetic foot. the outcomes of this project will try to objectively verify in the randomized controlled trial the impact of exercise on lower limb biomechanics, mobility, self-sufficiency, quality of life in patients with type 2 diabetes mellitus at risk or already developed diabetic foot syndrome.


Eligibility criteria:
inclusion criteria: * type 2 diabetes mellitus * sensoric neuropathy (mild - based on vpv 15-30 v or emg results, severe - based on vpt above 50 v or emg results) * diabetic foot with healed diabetic foot ulcers, inactive charcot foot exclusion criteria: * impossibility to exercise * amaurosis * non-compliance * critical limb ischemia * active ulcer, surgical wound * active charcot foot * active carcinoma * recent stroke (last 8 weeks) * recent myocardial infarction (last 8 weeks) * recent pta, pci, bypass (last 8 weeks) * myopathy * rheumatoid arthritis * cox-, gonartrosis of 3rd -4th grade.

Keywords: diabetic foot biomechanics quality of life prevention
sandostatin (octreotide lar) may lead to clinical improvement through receptor occupation optimisation

Conditions: Neuroendocrine Tumors; Carcinoid Syndrome

Summary: this is a multi-centric prospective interventional study in which patients with a symptomatic gep-net will receive octreotide lar every 2, 3 or 4 weeks. the basal dose and the dose adaptation will be left at the discretion of the investigator depending on the rate of symptom control. dose increase up to doses of 60 mg octreotide every 4 weeks, or increase of frequency up to 30 mg every 2 weeks can be done to obtain control of carcinoid symptoms, defined by at least a 50% decrease of the mean number of bowel movements per day and the total number of flushes over 7 days and a maximum frequency of less than 4 bowel movements a day. if only one symptom is present, analysis will be done for that symptom only: refer to table in statistical analysis the concentration of serum octreotide level will be realized with lcms/ms following the method of capron \& wallemacq. each blood sample should be taken 4 times per year just before the next injection of octreotide lar.


Eligibility criteria:
inclusion criteria: * written informed consent gep net ki 67 ≤ 10 % * histologically or cytologically confirmed gep net * appearance of carcinoid syndrome maximum 6 months before the inclusion * evaluable or measurable disease (recist 1.1) who ecog performance status 0-2 * positive somatostatin receptor scintigraphy * \>18 years * life expectancy of at least 12 weeks exclusion criteria: * uncontrolled concurrent disease which prevents the adequate management and follow-up of the net. * previous malignancy in the last past 3 years except malignancies estimated as completely cured. * current pregnancy or breast feeding * concomitant anti-tumoral treatment, except external beam radiotherapy

Keywords: net
weight loss in pre-hypertensive patients with diastolic dysfunction

Conditions: Obesity; Heart Disease; Weight Loss; Diastolic Dysfunction

Summary: the focus of this study is to observe the impact of weight loss in overweight individuals who have pre-hypertension (have a blood pressure reading of 121-139/81-89 mm hg). the specific focus is to observe the difference in diastolic dysfunction (heart function) in these individuals at the beginning of the study and then again after 24-28 weeks. diastolic dysfunction in this population indicates an increased risk of heart failure in the future. the aim of this study is to prevent or reduce the risk of heart failure in overweight individuals with pre-hypertension.

you will be enrolled in the study for 24-28 weeks and will be randomly assigned to one of two assigned group. one group of subjects (intervention group) will receive information on heart healthy diet, lifestyle recommendations and diet and exercise counseling with a dietitian in order to achieve at least 7% weight loss. the other group will receive standard of care i.e., information on heart healthy diet at baseline visit (standard of care group). the following is the time line of activities anticipated by the subject in each group. both the groups will be screened at 3 different visits within 4 weeks to determine eligibility. if you are eligible they will be randomized to either be in standard of care group or intervention group. after randomization, the "standard of care group" will come for baseline and final visit (24th week). the intervention group will have 14 weekly visits with a nutritionist and 1 monthly visit, about 40-50 minutes each visit (total of 15) in 24- 28 week time frame. the second monthly session will be the final assessment visit. both the groups will have a baseline assessment and a final assessment visit which will last about 3 hours.

Eligibility criteria:
inclusion criteria: * adults age ≥ 21 years * bmi ≥30 * individuals with diagnosis pre-hypertension at the time of screening, defined as either a blood pressure measurement of 130-139/85-89 mm hg * echocardiographic ef \>50% * echocardiographic evidence of diastolic dysfunction; exclusion criteria: * patients receiving antihypertensive medications * patients receiving diabetic medication

Keywords: heart disease obesity
mindfulness-based educational intervention on anxiety, depression, stress and quality of life on menopausal woman

Conditions: Menopause

Summary: mindfulness-based educational intervention is a structured program that incorporates principles of mindfulness to help individuals develop greater awareness and acceptance of their thoughts, feelings, and bodily sensations. the intervention typically includes mindfulness meditation practices, cognitive-behavioral techniques, and educational components about stress management and emotional regulation. by fostering a non-judgmental and present-focused attitude, participants learn to manage their symptoms more effectively and improve their overall quality of life.

menopause is a significant transitional phase in a woman's life, often accompanied by various physical, emotional, and psychological challenges. common issues during menopause include anxiety, depression, stress, and a decreased quality of life. addressing these concerns holistically is crucial for improving overall well-being. mindfulness-based educational interventions have gained recognition for their effectiveness in enhancing mental health and quality of life by promoting awareness and acceptance of present experiences. this study investigates the impact of a mindfulness-based educational intervention on anxiety, depression, stress, and quality of life in menopausal women.

Eligibility criteria:
inclusion criteria: * in age of menopause exclusion criteria: * age of menarche * older than 70 years old
suppressive antibiotic therapy for endocarditis

Conditions: Endocarditis

Summary: endocarditis are deadly infections, which nowadays occurs mainly among older patients with multiple comorbidities. the incidence is notably high among patients with valvular prosthetic or implantable devices. management of such situation usually requires intravenous antibiotic therapy along with removal of the infected prosthetic or device. however, such invasive procedures and revision surgeries may be judged unreasonable among these patients, who are then exposed to a high risk of infectious relapse when curative antibiotics are discontinued. in these situation, a long-course antibiotic therapy may be used in order to maintain lasting infection control, to limit the risks of relapse of infection due to the infected device retention, and ultimately to prolong survival. this strategy is already suggested in case of infected prosthesis joint retention (idsa 2013), and has been proposed for implantable device retention by the american heart rhythm society in 2017, but data regarding its modalities and outcomes are scare. the objectives of this study are to describe the survival of patient under long-term antibiotic therapy for endocarditis, at 6-months and 1 year after initiation. secondary outcomes includes modalities of the suppressive treatment prescribed, its security (secondary effects, tolerance) and to precise causes of death.


Eligibility criteria:
inclusion criteria: * major subject (≥18 years old) * subject having benefited from suppressive antibiotic therapy after collegial decision in cpr endocarditis during the period from january 1, 2016 to january 31, 2023 * subject not opposing the reuse of their data for the purposes of this research. exclusion criteria: * subject having expressed opposition to participating in the study * death or loss of sight of the patient before initiation of suppressive antibiotic therapy.

Keywords: endocarditis antibiotic therapy suppressive antibiotics long term treatment
perioperative hypothermia in patients submitted to laparoscopic urological surgery

Conditions: Hypothermia; Anesthesia; Anesthesia; Adverse Effect; Peroperative Complication; Postoperative Complications; Surgical Site Infection; Temperature Change, Body

Summary: hypothermia is a frequent perioperative complication. its appearance can have deleterious effects such as perioperative bleeding or surgical site infection. once the temperature has decreased, its treatment is difficult. preoperative warming prevents hypothermia, lowering the temperature gradient between core and peripheral compartments and reducing thermal redistribution. the most recent clinical practice guidelines advocate for active prewarming before induction of general anaesthesia since it is very effective in preventing perioperative hypothermia. however, the ideal warming time prior to the induction of anesthesia has long been investigated. this study aims to evaluate if different time periods of preoperative forced-air warming reduces the incidence of hypothermia at the end of surgery in patients submitted to laparoscopic urological surgery under general anesthesia. this is an observational prospective study comparing routine practice of pre-warming in consecutive surgical patients scheduled to laparoscopic prostatectomy or nephrectomy between august and december 2018. in this study 64 - 96 patients will be included and prewarming will be applied following routine clinical practice. the prewarming time will depend on the time the patient has to wait before entering in the operating theatre. measurement of temperature will be performed using an esophagic thermometer. patients will be followed throughout their hospital admission. data will be recorded using a validated instrument and will be analysed using the statistics program r core team.

maintaining patient's temperature above 36 grades celsius throughout the perioperative period is challenging. thus, it is essential to monitor temperature in order to be able to take measures to avoid the appearance of hypothermia. once the temperature has decreased, its treatment is difficult since the application of heat to the body surface takes a long time to reach the core thermal compartment. intraoperative warming alone cannot avoid postoperative hypothermia. the application of forced-air warming system during the preoperative period has been shown to be the most effective measure to prevent hypothermia and maintain intraoperative normothermia. however, long time periods of prewarming would not be efficient. thus, the ideal warming time prior to the induction of anesthesia has long been investigated. due to the searching of optimal prewarming time, the conductance of this study is justified.

Eligibility criteria:
inclusion criteria: * patients undergoing elective laparoscopic urological surgery under general anesthesia. exclusion criteria: * active infection * intake of antipyretics within 24 hours before surgery * neuropathy * thyroid disorders * peripheral vascular disease * skin lesions * history of hypersensitivity to skin contact devices.

Keywords: prewarming perioperative hypothermia esophageal thermometer