Kornimate/medical-research-clean huggingface dataset:
cardiovascular risk factors, body composition, fitness levels and quality of life in overweight and obese 8-17 year olds

Conditions: Childhood Obesity; Type 2 Diabetes; Hypercholesterolemia; Hypertension

Summary: this project will address the important area of childhood obesity and the risk of cardiovascular disease associated with obesity. this is a serious health concern since children who are overweight or obese are prone to other medical conditions including high blood pressure, abnormal lipid profiles,and type 2 diabetes. although exercise and nutrition programs are recommended, evidence for the efficacy of these programs in improving cardiovascular health is lacking. specific aims: a) improve cardiovascular risk factors, b) increase physical fitness levels, c) improve lean body mass, d) enhance qol of the child e) influence adherence rates to exercise and a healthy lifestyle change both during and beyond the conclusion of the program. hypothesis 1a: compared to baseline and matched controls, children randomized to a 10 week multidisciplinary fitness and nutrition program will show significant improved levels of cardiovascular risk factors. specific aim 2: to determine if a multidisciplinary fitness and nutrition program, when compared with a matched, wlc group will show a change in whole body assessment including a decrease in fat mass, an increase in percent lean body mass, and a decrease in percent body fat, as measured utilizing dual-energy x-ray absorptiometry hypothesis 2a: compared to baseline and matched controls, children randomized to a 10 week multidisciplinary fitness and nutrition program will show improved whole body assessments including. specific aim 3:to determine if a multidisciplinary fitness and nutrition program, when compared with a wlc group will show improved levels of fitness. hypothesis 3a: compared to baseline and matched controls, children randomized to a 10 week multidisciplinary fitness and nutrition program will show significant improvements in fitness including.


Eligibility criteria:
inclusion criteria: * : a) in the 85th percentile body mass index(bmi), standardized for age and gender; b) have hypercholesterolemia as defined as total cholesterol \> 170 mg/dl or ldl \> 110 mg/dl; and / or c) hypertension as defined as \>116/76 for 8-10 year olds, \> 120/80 for 10-13 year olds, and \>125/890 for 14-17 year olds. exclusion criteria: * 1) age \ 17 years; 2) the determination of significant abnormalities on an initial graded exercise test performed by a pediatric cardiologist; 3) past history of chemotherapy or whole-body radiation therapy

Keywords: pediatric overweight/obesity, dexa, fitness
effect of exercises on physical health and cardiorespiratory fitness in obese women

Conditions: Obesity

Summary: the study will be a randomized clinical trial and will be conducted in services hospital lahore. the sample size of 50 patients will be taken in this study to find the effects of high intensity interval training versus moderate intensity exercises on physical health and cardiorespiratory fitness in obese women. patients will be divided into two groups (group a will be treated with high intensity interval training and group b will be treated with moderate intensity exercises). eligible participants attended three session per week. overnight fast, resting metabolic rate and blood pressure will be assessed. an oral glucose test will be assessed and baseline blood samples will be used for lipoprotein analysis. pacer test and step test performed in the each session. a regular follow-up visits to department and a final assessment will be made at the end of last week by using questionnaire and resulting improvement will shown in results after completion. data will be analyzed on spss 25.

the study will be a randomized clinical trial and will be conducted in services hospital lahore. the study will be completed within the duration of ten months. non probability convenient sampling study technique will be used to collect the data. the sample size of 50 patients will be taken in this study to find the effects of high intensity interval training versus moderate intensity exercises on physical health and cardiorespiratory fitness in obese women. patients will be divided into two groups (group a will be treated with high intensity interval training and group b will be treated with moderate intensity exercises). eligible participants attended three session per week. overnight fast, resting metabolic rate and blood pressure will be assessed. an oral glucose test will be assessed and baseline blood samples will be used for lipoprotein analysis. pacer test and step test performed in the each session. a regular follow-up visits to department and a final assessment will be made at the end of last week by using questionnaire and resulting improvement will shown in results after completion. data will be analyzed on spss 25.

Eligibility criteria:
inclusion criteria: * women between the ages of 17-30 years * bmi 25-35kg/m2. * sedentary (\< 30 minutes of structured activity per week) * normal glucose tolerance ( fasting glucose \<100mg/dl) * no use of medications known to affect body composition or metabolism * all participants will be non smoker * no mi history * no previous surgery. * free from known injury or known clinical conditio exclusion criteria: * bmi \< 30 kg/m2 known clinical condition including family history of sudden death, uncontrolled hypertension, type 1 and type 2 diabetes and cardiovascular diesease. • participants will be excluded if they report in competitive exericise

Keywords: high intensity exercise moderate intensity exercise
a study of peginterferon alfa-2a (pegasys) and ribavirin (copegus) combination therapy in participants with chronic hepatitis c (chc) and various degrees of renal impairment

Conditions: Hepatitis C, Chronic

Summary: this study will evaluate the pharmacokinetics (area under the curve \[auc\], maximum concentration \[cmax\], and other parameters) and tolerability of peginterferon alfa-2a and ribavirin combination therapy following single and multiple doses in participants with chc infection and moderate to severe renal impairment or end-stage renal disease (esrd) receiving hemodialysis. the anticipated time on study treatment is up to 48 weeks, and the target sample size is 48 individuals.


Eligibility criteria:
inclusion criteria: * adults 18 to 65 years of age * chc infection as shown on enzyme-linked immunosorbent assay (elisa) and radioimmunoblot assay (riba) or quantifiable hepatitis c virus (hcv) ribonucleic acid (rna) greater than (\>) 2000 copies per milliliter (copies/ml) * use of two forms of contraception during study and 6 months after the study in both men and women * normal renal function (creatinine clearance \[crcl\] \>80 milliliters per minute \[ml/min\]), moderate renal impairment (crcl 30 to 50 ml/min), severe renal impairment (crcl less than \[\<\] 30 ml/min), or esrd requiring hemodialysis * patients with esrd must have been undergoing hemodialysis for at least 2 months exclusion criteria: * women who are pregnant or breastfeeding * male partners of women who are pregnant * conditions associated with decompensated and/or chronic liver disease * human immunodeficiency virus (hiv) infection * interferon or ribavirin treatment within the previous 3 months * poor hematologic function, including unstable hemoglobin * significant comorbidity or severe illness which would make the participant unsuitable for the study * acute renal failure
comparison of ketorolac tromethamine oral drops versus naproxen for moderate to severe back pain treatment

Conditions: Back Pain

Summary: the purpose of this study is to evaluate the non-inferiority clinical efficacy of two different drugs in the treatment of patients diagnosed with moderate to severe back pain treatment.

* double-blind, double-dummy, non-inferiority, prospective, parallel group, intent to treat trial. * experiment duration: 04 days. * 03 visits (days 0, 2 and 4). * efficacy will be evaluated for back pain relief based on visual analogic scale. * adverse events evaluation.

Eligibility criteria:
inclusion criteria: * consent of the patient or legal guardian. * men or women aged between 18 and 65. * diagnosis of acute low back pain with moderate to severe pain (visual analogic score greater than 4 cm) exclusion criteria: * fracture confirmed by x-ray * diagnosis of infection, fever, * pregnancy, lactation; * diagnosis of fibromyalgia; * hypersensitivity to ketorolac tromethamine, any of the ingredients of the formula or other nonsteroidal anti-inflammatory
conventional versus digital 3d printed complete removable dentures

Conditions: Denture, Complete

Summary: the study is a crossover, randomised, controlled clinical trial that will compare and evaluate patients' satisfaction and oral microbiota proliferation in two groups. group i: conventionally manufactured crd group ii: 3d-printed (three-dimensionally printed) cad/cam (computer-aided design/computer-aided manufacturing) manufactured crd, the participants will be selected according to inclusion and exclusion criteria and will be randomly allocated into both groups and then shuffled to the other group using the research randomizer program.

the study will be performed at the outpatient clinic of the oral and maxillofacial prosthodontics department, faculty of dentistry, ain shams university. eleven edentulous male patients will be selected and recruited for this clinical trial after the informed consent provided by faculty of dentistry ain shams university-research ethics committee (fdasu-rec) is assigned. they will be rehabilitated with conventional and 3d-printed cad-cam (computer-aided design/computer-aided manufacturing) crd. participants will be randomly assigned to receive either conventional or 3d-printed cad/cam-manufactured crd for three months before crossing over to the other set. care provider , investigator and participants will be blinded to the group allocation. outcomes will be evaluated, including patient satisfaction with dentures and oral microbial adherence. the outcomes will be measured at baseline and at 1 and 3 months. the obtained data will be recorded, tabulated, and statistically analyzed using the appropriate tests for comparison between each group.

Eligibility criteria:
inclusion criteria: 1. patients who have been completely edentulous in both jaws (maxilla and mandible) for at least a year and require treatment with complete dentures. 2. the age of patients ranges from 45 to 60 years old. 3. patients with a class i maxillo-mandibular relationship. 4. patients with adequate inter-arch space. 5. patients with good neuromuscular control. 6. patients without any temporomandibular joint disorder. exclusion criteria: 1. patients with any oral diseases that may affect complete denture construction. 2. patients with bad oral hygiene. 3. patients with oral parafunctional habits. 4. hysterical patients. 5. patients will undergo or have previously received chemotherapy or radiotherapy. 6. smokers or drug- addicted patients

Keywords: 3d printing cad/cam complete dentures
comparison of minimal invasive lens surgery and traditional cataract surgery

Conditions: Congenital Cataract

Summary: previously, we have developed a minimal invasive lens surgery in the purpose of reduce post-operative complications of congenital cataract. this prospective, randomized controlled study aims at comparing the prognosis of the minimal invasive lens surgery and the traditional cataract surgery for treating congenital cataracts.

patients with congenital cataract that requires surgical intervention are enrolled. then the patients are assigned to two groups: group i: the participants receive a minimal invasive lens surgery, while in group ii, the participants receive a traditional cataract surgery. a secondary intraocular lens implantation is performed when the patient is two years old for both group i and group ii. investigators then compare the visual acuity, incidence of high intraocular pressure, incidence of visual axis opacification, uveitis and iris/pupil abnormality between two groups, to evaluate and compare the prognosis of minimal invasive lens surgery and traditional cataract surgery for treating congenital cataracts.

Eligibility criteria:
inclusion criteria: * age between 1 month and 24 months * uncomplicated congenital cataract (≥ 3 mm central dense opacity) in one or both eyes with an intact non-fibrotic capsular bag * informed consent signed by a parent or legal guardian exclusion criteria: * confirmed or suspected hereditary cataract, including and not restricted to family history of congenital cataract * intraocular pressure \>21 mmhg * preterm birth (\<28 weeks) * presence of other ocular diseases (keratitis, keratoleukoma, aniridia, glaucoma) or systemic disease (congenital heart disease, ischemic encephalopathy) * history of ocular diseases (any congenital eye diseases, such as, congenital cataract, congenital glaucoma, congenital aniridia) in the family * history of ocular trauma * microcornea * persistent hyperplastic primary vitreous * rubella * lowe syndrome

Keywords: congenital cataract minimal invasive surgery secondary intraocular lens implantation
marginal bone loss around mandibular implant-retaining overdentures and implant supported fixed hybrid prosthesis

Conditions: Bone Loss in Jaw; Dental Implant Failure Nos; Dental Implant Failed

Summary: few if any studies have compared marginal bone loss (mbl) around implant-retaining overdentures (2 implants with locators) versus implant supported fixed hybrid prosthesis (over 4 implants) in the mandible.

material and methods: patients of the saint joseph university dental clinics, who have already in their records peri-apical radiographs of the implants post loading, will be divided in 2 groups depending on the prosthetic treatment that they have had for 5 years in mouth, and will be recalled for a check-up session during which the investigators will take new peri-apical x-rays by means of the parallel long-cone technique for the implants that are supporting/retaining the prosthesis. a total of minimum 50 implants placed in a minimum of 19 patients will be examined. the mean mesial and distal radiographic mbl and bone to implant contact (bic) will be recorded by comparing the two x-rays for each implant. the investigators will also investigate the possibly related factors that may have contributed to this marginal bone loss such as the medical history, smoking habits, oral hygiene, compliance, presence of keratinized tissue and possibility of proper cleaning. results: the investigators aim to find a statistically significant difference in the marginal bone loss around implants assisting these two types of prosthesis and a possible correlation with some risk and modifying factors.

Eligibility criteria:
inclusion criteria: * patients treated with mandibular implant-retaining overdentures (2 implants) * patients treated with mandibular implant-supported fixed hybrid prosthesis (4 implants) * patients having in their records a post-loading peri-apical radiograph for the implants * patients who have had their prosthesis for 5 years in mouth exclusion criteria: * patients treated with mandibular implant-retaining overdentures with more or less than 2 implants * patients treated with mandibular implant-supported fixed hybrid prosthesis with more or less than 4 implants patients treated with any other prosthetic option on implants patients who don't have a post-loading peri-apical radiograph in their records
serial measurement of capillary blood lactate in the management of sepsis

Conditions: Sepsis

Summary: determination of capillary lactate by using "point-of-care" technique is accessible, fast and allows to quantify the circulatory and metabolic dysfunction caused by sepsis. compared to conventional assay techniques in arterial blood, capillary assay technique may have an increased susceptibility to metabolic alterations induced by sepsis in its initial stages. this increased sensitivity is not necessarily relevant in the management of the most serious patients for whom the diagnosis is obvious, but it could be very useful in patients for whom a diagnosis of severe sepsis or shock have not yet been adopted, particularly to help better identify patients who would require intensive management and avoid the installation of these serious disorders.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * installation without any plausible explanation of at least one of the following clinical criteria: * chills, fever, mottling, respiratory rate\> 20/min; sat02 \ 94% with more than 4l o2, heart rate \> 90/min,systolic blood pressure \< 100 mmhg or 40 mmhg lower compared with normal values, glasgow coma score \< 14. or: .a combination of two (or more) of clinical and laboratory criteria for sepsis. * signed informed consent form exclusion criteria: * need in its current treatment of aerosol administration of beta agonists at a frequency greater than one per 8 hours; * targeted therapeutic measures have already stated for more than 60 minutes; * diagnosis other than sepsis; * malignant neoplasm or other progressive disease and expected survival was less than 3 months.

Keywords: sepsis capillary blood lactate serial measurement of capillary
bedtime aceis/arbs versus morning aceis/arbs for reverting non-dipping hypertension

Conditions: Hypertension; Non-Dipping

Summary: background: non-dipping (nd), defined as a \<10% decrease in blood pressure (bp) during sleep, is an independent significant predictor of cardiovascular outcome in hypertensive patients. a few anti-hypertensive medications, including angiotensin receptor blockers (arbs) and angiotensin converting enzyme inhibitors (aceis), may normalize dipping if administered at night. chinese data are scarce and there are no prospective studies on cardiovascular outcomes in chinese patients. aim: to determine if the bedtime administration of aceis and arbs is more effective at normalizing nd than morning administration. as a pilot project, the feasibility of recruiting hypertension patients in primary care for ambulatory blood pressure monitoring (abpm) and conducting a clinical trial will be evaluated such that future larger randomized trials can be planned to determine treatments for nd. method: fifty patients diagnosed with essential hypertension who are receiving either aceis or arbs and diagnosed with nd will be randomized to take aceis or arbs either early morning or before bedtime. a follow-up 48-hour abpm will be performed after 4-6 weeks to examine post-treatment changes in bp and nd status. outcome: the primary outcome of this proposed study is the proportion of nd at 6 weeks; secondary outcomes will include (i) mean awake and asleep sbp/dbp of 48-hour duration (ii) feasibility of this pilot study will be assessed by recruitment and dropout rates during the study period. potential: this pilot study will provide the basis for a future larger randomized controlled study to further examine the treatment for nd in primary care.


Eligibility criteria:
inclusion criteria: * patients who are taking an acei or an arb * \>18 years of age * chinese and * received a diagnosis of primary ht. exclusion criteria: * severe ht as defined by a clinic systolic bp ≥180 mmhg and/or diastolic bp ≥ 110 mmhg * allergic reaction or intolerance to the current acei or arb * unable to provide consent * pregnancy * night-time worker * occupational drivers since patients will be asked not to move during bp measurements, which may induce potential danger in driving * taking anti-coagulants to avoid causing bruises when using abpm * known atrial fibrillation since abpm use has not been validated in this group * known hyperkalemia * abpm discovered hypotension (mean sbp \< 100 and/or mean dbp \< 60) because these patients may need to stop their medications * reported sleep time of \<4 hours per night (at least seven readings are recommended during sleep for an abpm recording to be valid, and a sleeping time \< 4 hours is unlikely to generate valid results).
assessment of the safety, tolerability and efficacy of medi8968 in subjects with moderate to severe hidradenitis suppurativa

Conditions: Hidradenitis Suppurativa

Summary: the purpose of this study is to gain initial evidence for the safety, tolerability and efficacy of medi8968 for the treatment of subjects with moderate to severe hidradenitis suppurativa


Eligibility criteria:
inclusion criteria: * hidradenitis suppurativa (hs) (moderate to severe) * diagnosis of hs for at least 1 year * at least 5 active inflammatory lesions in at least 2 locations * on a stable dose of antibiotics and/or analgesics for at least 4 weeks (if already taking these medications) * average pain score of 3-9. exclusion criteria: * history of cyclic neutropenia * laboratory assessment abnormalities * underlying disorder considered unsuitable for inclusion * other skin diseases that may interfere with hs assessment * pregnancy or planning for pregnancy
a digital intervention to prevent initiation of opioid misuse in adolescents in school-based health centers

Conditions: Opioid Misuse

Summary: this study's specific aims were to: develop a digital intervention as a prevention intervention through focus groups with 40 youth; pilot-test the developed digital intervention with 30 adolescents, using methods from the investigator's prior research; develop implementation strategies and partners through focus groups with 50 school based health alliance affiliates and 30 adolescents from an advisory council.

most opioid misuse begins during adolescence and young adulthood. adolescence is the time to intervene with prevention interventions (i.e., interventions focused on adolescents who have not yet misused opioids) in settings like school-based health centers (hcs), yet few interventions exist that prevent initiation of opioid misuse. "serious videogame" interventions can improve health behaviors. they meet adolescents "where they are," and compared to standard interventions, they can reach large populations, with consistent fidelity, place limited demands on personnel/resources, and facilitate rapid sustainable distribution, all at a potentially lower cost. this study harnessed the power of videogame interventions and incorporated components of effective substance use prevention programs to develop an evidence-informed intervention to prevent the initiation of opioid misuse in adolescents. building on our experience developing videogame interventions and in partnership with the national school-based health alliance (sbha), we developed and tested a new videogame intervention, playsmart. playsmart was built upon our playforward videogame intervention platform that has demonstrated efficacy in improving attitudes and knowledge related to risk behaviors. through rigorous formative work and with input from adolescents, and our sbha and game development partners, we created the playsmart videogame intervention. playsmart is designed to provide players with behavioral skills and knowledge through repetitive and engaging videogame play to target adolescent perception of risk of harm from initiating opioid misuse. the gap in the research on preventing initiation of opioid misuse in youth and in implementing prevention programs with good fidelity needs to be urgently addressed given the high prevalence of adolescent opioid misuse and overdose. this research has the potential to create a videogame intervention to prevent initiation of opioid misuse with far-reaching and sustained impact on adolescents.

Eligibility criteria:
inclusion criteria: * adolescent participants must attend high school that has a school-based health center, to participate in pilot testing exclusion criteria: * failure to meet inclusion criteria