Kornimate/medical-research-clean huggingface dataset:
effect of deep neck flexors biofeedback training and post isometric relaxation in chronic mechanical neck pain

Conditions: Deep Neck Flexors Training; Post Isometric Relaxation

Summary: this study will be conducted to explore the superiority of effectiveness between muscle energy technique combined with deep neck flexors training, met alone, or dnf training alone in terms of pain intensity, neck function, forward head posture, cervical range of motion and deep neck flexors muscles endurance in patients with chronic mechanical neck pain(cmnp).

patients will be grouped into three groups; each group composed of 15 patients suffering from cmnp. the personal history of each patient who participated in the study will be collected, the patient will receive an oral explanation of the procedures and signed a consent form . the weight and height of each patient will be obtained using the standard weight scale. the pain intensity level will be assessed via a visual analogue scale (vas). the disability level will be assessed via neck disability index (ndi). the forward head posture will be assessed via photographic method of craniovertebral angle (cva) and the angle will be calculated by using kinovea software. the range of motion will be assessed via universal goniometer (ug). the endurance of the neck muscles will be assessed via pressure biofeedback unit (pbu). assessment will be done before treatment and after 12 treatment sessions.

Eligibility criteria:
inclusion criteria: 1. age group 20-40 years of female and male patient. 2. patient with neck pain duration more than 3 months and less than one year. 3. subjects who could not maintain blood pressure at increments of 24 mmhg from the initial 20 mm hg 4. patients who have moderate neck pain and disability scoring 15 to 24 from 50 on neck disability index. . 5. pain intensity more than 3 and less than 7 on visual analogue scale (vas) 6. cva less than 49° exclusion criteria: 1. people with severe neck pain. (disability scoring more than 25 on neck disability index) 2. if they are participated in a neck rehabilitation program over the last 6 months 3. major circulatory or respiratory disorder 4. pregnant women or 3 months postnatal 5. patient with structural instability and degenerative conditions of cervical spine. 6. body mass index more than 30. 7. post traumatic or infective conditions. 8. any surgeries around cervical spine 9. vertigo patient 10. un-cooperative patient (gupta et al., 2022).
study of pembrolizumab (mk-3475) in participants with advanced non-small cell lung cancer (mk-3475-025/keynote-025)

Conditions: Non-small Cell Lung Cancer

Summary: this study is being done to evaluate the safety and efficacy of pembrolizumab (mk-3475) in participants with advanced non-small cell lung cancer (nsclc) tumors that are positive for programmed cell death ligand 1 (pd-l1): the hypothesis is that treatment with pembrolizumab will result in a clinically meaningful overall response rate (orr).


Eligibility criteria:
inclusion criteria: * histologically or cytologically confirmed diagnosis of non-small cell lung cancer (nsclc) that is pd-l1 positive per central laboratory review * at least one measurable lesion * radiographic progression of nsclc after treatment with a platinum-containing doublet for stage iiib/iv or recurrent disease * eastern cooperative oncology group (ecog) performance scale 0 or 1 * adequate organ function exclusion criteria: * systemic cytotoxic chemotherapy, biological therapy, or major surgery within 3 weeks of the first dose of trial treatment * systemic steroid therapy within 3 days prior to the first dose of trial treatment or any other form of immunosuppressive medication * expected to require any other form of systemic or localized antineoplastic therapy while on trial * history of prior malignancy, with the exception of basal cell carcinoma of the skin, superficial bladder cancer, squamous cell carcinoma of the skin, or in situ cancer * active central nervous system (cns) metastases and/or carcinomatous meningitis * active autoimmune disease or documented history of autoimmune disease or syndrome that requires systemic steroids or immunosuppressive agents * prior therapy with an anti-pd-1, anti-pd-l1, anti-pd-l2, anti-cd137, or anti-cytotoxic t-lymphocyte-associated antigen-4 (ctla-4) antibody * concurrent or past history of interstitial lung disease * pregnant or breast-feeding, or expecting to conceive or father children within the projected duration of the study, starting with screening visit through 120 days after the last dose of pembrolizumab

Keywords: pd1 pd-1 pdl1 pd-l1
chances in portal system flow after two bariatric procedures

Conditions: Portal Vein Thrombosis

Summary: obesity if a health endemic problem over the entire world. bariatric surgery is the best chance for those patients with morbid obesity to loss weight and to maintain the loosed weight. metabolic surgery is the new name for bariatric surgery like sleeve gastrectomy and gastric by pass due to the recognized changes in the homeostasis of the hormonal secretion responsive to the hunger status. after sleeve gastrectomy we observe many patients with thrombus of the portal vein system. this phenomena may be attributed to changes in the portal flow due to devascularization of the great curvature of the stomach. the aim of the study is to compare the portal flow by intra-operative doppler ultrasound before and after surgery of the two procedures as sleeve gastrectomy and gastric bypass, were the vascularization is not changed by the surgery.


Eligibility criteria:
inclusion criteria: * patients accepted for bariatric surgery for the bariatric surgery committee. * primary procedure * no hypercoagulability status know exclusion criteria: * hypercoagulability status * patients after any abdominal surgery of the forgut
whole-body 3d t1-weighted mr imaging anatomical sequences: ge mdixon vs fse (view) approaches in prostate cancer.

Conditions: Prostate Adenocarcinoma; Metastasis

Summary: this study will assess and compare the diagnostic performances and image quality of two wb 3d t1-weighted mr imaging sequences for bone and node staging in patients with prostate cancer : the fse sequence and a gradient echo (ge) sequence. the latter sequence's main feature is its acquisition time of approximately 1.5 minutes, compared to 18 min for the fse sequence, reducing the exam's acquisition time, patient discomfort and increasing machine availability.

whole-body (wb) magnetic resonance (mr) imaging has increasingly been used for the screening of bone and soft-tissue metastases in patients with prostate cancer (1). a limitation for its implementation is the 45-60 minutes duration of current wb mri examinations. conventional wb mr imaging studies consisted of anatomical two-dimensional (2d) t1-weighted and fat-suppressed fluid-sensitive (proton-density fat-saturated (pdfs) or short-tau inversion-recovery (stir)) and of a functional diffusion-weighted imaging sequence. recent research has confirmed the feasibility of replacing the 2d anatomical sequences by a single three-dimensional (3d) t1-weighted fast spin echo (fse) sequence (2). this study will assess and compare the diagnostic performances and image quality of two wb 3d t1-weighted mr imaging sequences for bone and node staging in patients with prostate cancer : the fse sequence and a gradient echo (ge) sequence. the latter sequence's main feature is its acquisition time of approximately 1.5 minutes, compared to 18 min for the fse sequence, reducing the exam's acquisition time, patient discomfort and increasing machine availability. the aim of this study is to evaluate the feasibility of the replacement of the wb 3d t1-weighted fse mr imaging sequence by the wb 3d t1-weighted ge mr imaging sequence.

Eligibility criteria:
inclusion criteria: * prostate cancer with high risk for metastases exclusion criteria: * contraindications to mri

Keywords: mri mri sequences prostate cancer cancer staging bone metastasis node metastasis
the effect of hippotherapy simulator in cerebral palsy

Conditions: Cerebral Palsy

Summary: hippotherapy simulators imitate the passive movements of the horse, producing simple movements similar to those of the horse. hippotherapy simulators are intended to improve sitting balance, postural control and trunk balance. the aim of this study was to research the therapeutic effects of hippotherapy simulator on sitting balance, trunk control and upper extremity skills in individuals with cerebral palsy (cp).

spastic cp will be participate the study between the ages of 4 and 18 years. children's classified with gmfcs and macs. the eligible participants will be allocated two groups, including hippotherapy simulator training group and traditional physiotherapy control group. all the assessments will be performed before and after the training in the 8-week training groups. the control group individuals will be given a traditional physiotherapy two days per week for a total of 8 weeks (traditional physiotherapy session will last 45 minutes). hippotherapy simulator training group will receive a traditional physiotherapy and hippotherapy simulator training, two days a week for a total of 8 weeks (30 minutes traditional physiotherapy session+15 minutes hippotherapy simulator training). all sessions will be performed in the clinic with the specialist physiotherapist.

Eligibility criteria:
inclusion criteria: * diagnosis of spastic cerebral palsy voluntary participation * age between 4-18 years, * gmfcs level i-ii-iii * macs level i-ii-iii * have the ability to sit upright with support exclusion criteria: * not voluntary to participate in the research, * botox in the last 6 months * hip or spine surgeries in the last 6 months

Keywords: cerebral palsy hippotherapy simulator
evaluation of two versions of a digital problem solving tool for the general public specific for the covid-19 pandemic

Conditions: Problem Solving

Summary: a digital problem solving tool was tailored to people in the general public with practical or emotional problems during covid-19. content analysis were used to account for the types of problems participants used the tool to solve. participants were randomized to one of two versions of the problem solving tool, a simple and a more advanced graphical interface. these versions were compared on participant-rated usability, credibility and the level of actual interaction with the tool.


Eligibility criteria:
inclusion criteria: * can use the swedish language * access to, and knowledge how to use, a digital internet-capable device exclusion criteria: * under 16 years * no practical or emotional problems during pandemic
use of text messages to improve care for children following an ed visit for asthma

Conditions: Asthma

Summary: background asthma is a prevalent and troublesome pediatric condition. in 2013, emergency department (ed) providers treated over 3,500 cases of asthma-related complaints at children's hospitals and clinics of minnesota. pediatric ed visits for asthma exceeds billions of dollars annually when including direct cost and lost productivity. many of these visits and resultant costs are avoidable. patients with well-controlled asthma do not typically exhibit these patterns, while patients with poorly controlled asthma show patterns of increased utilization of healthcare resources and lower quality of life. evidence suggests that a text message reminder and educational program might positively influence pediatric asthma care practices. research question does a targeted ed based text message intervention program improve outpatient follow-up and routine preventive care in pediatric asthma patients? methods study subjects will be block randomized based on age and insurance group. the experimental group will receive text messages with guidance towards follow-up care with their pcp and the importance of the flu vaccine for children with asthma. the control group will receive a series of educational self-care and health based text messages unrelated to asthma or the flu vaccine. some self-report of behaviors will be captured via text message response. analysis primary outcomes for the educational versus targeted text message groups will be compared use chi-square tests. additional adjustments may be applied for missing data or if, despite randomization, there is substantial imbalance between group in key covariates (eg race/ethnicity, insurance type or asthma severity.)


Eligibility criteria:
inclusion criteria: * caregivers of patients aged 4 - 17 years (inclusive) will be eligible for study participation if they meet the following criteria: 1. presentation to the ed with a chief complaint related to an asthma exacerbation such as shortness of breath, respiratory distress, wheezing, etc... 2. receive an albuterol treatment in the ed 3. previous history of asthma as represented in the medical record or by parental report 4. have a cell phone that is able to receive text messages 5. able to communicate and provide consent in english or spanish exclusion criteria: * caregivers of patients will be excluded from this study for the following reasons: 1. first episode of wheezing 2. admitted to the hospital 3. co-morbid respiratory disease: 1. cystic fibrosis 2. bronchiectasis 3. pulmonary hypertension 4. other chronic lung disease 4. current cancer diagnosis 5. previous cardiovascular surgery 6. inflammatory bowel disease 7. sickle cell disease

Keywords: pediatrics emergency medicine text messaging
keyscope study in uganda

Conditions: Abdominal Neoplasm

Summary: keyscope and keyloop (collectively called keysuite) are laparoscopic prototypes that the investigators have designed for the resources, needs and challenges of low- and middle- income countries (lmics). keyscope is a laparoscope that plugs into a laptop computer to display images during surgery. it links to a telementoring application so that experienced surgeons can mentor surgeons in capacity-building partnerships. keyloop is a laparoscopic retractor that lifts the abdominal wall during surgery, obviating the need for a constant power supply and medical-grade carbon dioxide. the investigators will perform a clinical first-in-human study at the uganda cancer institute. ugandan surgeons will use the keysuite devices to perform biopsies of intra-abdominal tumors.


Eligibility criteria:
inclusion criteria: * diagnosis of intra-abdominal mass suspicious for cancer * body mass index (bmi) of 18-30 * weight 20-100kg * biopsy necessary to determine cancer diagnosis and classify pathology * surgeon determine that laproscopic biopsy it technically appropriate exclusion criteria: * significant comorbidities * previous major abdominal surgery * current pregnancy
shared decision-making: afib 2gether mobile app

Conditions: Atrial Fibrillation New Onset

Summary: shared decision-making: afib 2gether™ is a research study that focuses on a mobile application developed by pfizer, inc with consultation from dr mcmanus' called afib 2gether™. through this app, patients can determine their risk of stroke due to atrial fibrillation and prioritize questions and concerns for discussion with their cardiology provider.


Eligibility criteria:
inclusion criteria: providers: * caring for at least 3 patients aged 18 years and older * have at least 3 patients with international classification of diseases tenth revision (icd-10) diagnostic code consistent with atrial fibrillation (af) or atrial flutter * have at least 3 patients with a cha2ds2-vasc stroke risk score of 2 or more * have at least 3 patients who are not on anticoagulation * have at least 3 patients with upcoming appointments within the next 4 months patients: * age 18+ * preferred language is english * atrial fibrillation diagnosis * chads vasc score 2 or higher * not on anticoagulants * no watchman or atrial appendage closure * had an ambulatory care center (acc) cardiology appointment in the past 12 months * future appointment in the next 4 months with the same provider exclusion criteria: providers: * providers who do not care for at least 3 patients aged 18 years and older * have patients that do not have an icd-10 diagnostic code consistent with af or atrial flutter * does not have patients with a cha2ds2-vasc stroke risk score of 2 or more * their patients are on anticoagulation * their 3 patients do not have an upcoming visit within the next 4 months patients: * under the age of 18; patients * no icd-10 diagnostic code consistent with af or atrial flutter * did not have a visit with a cardiovascular medicine specialist in the previous one year * patients with a cha2ds2-vasc score less than 2 * currently prescribed an anticoagulant * no upcoming cardiology visit in the next 3 months * has a watchman device or left atrial appendage closure surgery * on hospice or for whom life expectancy is less than six months and patients * bleeding episode or fall with injury in the last four weeks * does not speak english * prisoner
safety demonstration of increasing intensities of electrical stimulation delivered to the bulbospongiosus muscle

Conditions: Premature Ejaculation

Summary: the company suggests a new concept of treatment for pe: transient inhibition of striated muscle contraction by a transcutaneous stimulation device. this study aim is to evaluate the safety of delivering increasing electrical stimulation intensities to the subject's perineum, using a tens technique and equipment, followed by a 72-hour postoperative follow-up.


Eligibility criteria:
inclusion criteria: * generally healthy * ability to follow study instructions and complete study assessment tools exclusion criteria: * history of cardiovascular disorders * any type of implanted pacemaker/defibrillator * hypertension * diabetes mellitus * local dermatological disease * local skin irritation/lesions * any neurological disorder * any psychiatric disease and/or psychiatric medications
scleroderma et adipose-derived stroma cells

Conditions: Systemic Sclerosis

Summary: systemic sclerosis (ssc) is an auto-immune orphan disease mainly characterized by an alteration of the microvascular network, and by cutaneous and visceral fibrosis. hands are frequently affected, as a consequence of ischemic phenomena and cutaneous fibrosis. as a result, patients suffer from everyday disability, with consequences on their occupational activities and social contact, sometimes severely altering their quality of life. to date, no anti-fibrosis treatment has proven effective; existing vasodilation treatments are unfortunately not very effective, and are associated with adverse effects or restrictions. it is consequently of utmost importance that an effective treatment for sclerodermic hands be developed. the injection of adipose autologous tissue is a common practice in plastic surgery, and has been known for over a century. adipose tissue, originally used to increase volume, is also characterized by trophic properties associated to stromal vascular fraction (svf), which contain multipotent stem cells, capable of tissue repair. interestingly, some svf cells can be angiogenic and anti-inflammatory, which could improve damage seen with ssc. the injection of svf into the fingers would also make it possible to control the production of the extracellular matrix and to improve the balance between fibrosis and fibrolysis, resulting in an improvement of cutaneous sclerosis the main purpose is to evaluate the efficacy of svf injections in the fingers of patients suffering from ssc on the cochin hand functional scale evaluated at 12 months, in comparison to the control group.


Eligibility criteria:
inclusion criteria: * systemic sclerosis ( limited or diffuse cutaneous shape) * men and women of more than 18 years old * patients wishing for a therapeutic alternative * functional disability of the dominant hand authenticated by a functional index of the hand of cochin functional scale upper to 20 exclusion criteria: * body mass index (weight in kilograms divided by height in meters squared) lower than 18 * finger infection (including infected ulcer, ulcer with signs of local inflammation and clinical suspicion of osteitis) * contraindication to surgery * prescription of a new systemic treatment for ssc in the month before the inclusion subjects infected with hiv, hcv ( hepatitis c virus) , hbv (hepatitis b virus), htlv ( human t-cell leukemia virus) and syphilis * pre-menopausal women of reproductive age, taking no contraceptive method * patients receiving immunosuppressive therapy not including corticosteroid therapy \< 10 mg/d and methotrexate
clinical effect of photoactivated disinfection on primary root carious lesions after partial caries removal

Conditions: Primary Root Caries

Summary: the problem of root caries has been increasing in last decades as the an average life expectancy is rising. due to progress of medicine and dentistry humans also maintain natural dentition longer. the aim of the study is to determine the effectiveness of photoactivated disinfection / photodynamic therapy / photodynamic antimicrobial therapy in elimination of cariogenic bacteria after manual root caries removal. if proved to be effective in eliminating bacteria from prepared cavity pad could be incorporated in the protocol of treatment of root cavities.

elimination of cariogenic bacteria is to be determined in this study - mutans streptococci, lactobacillus spp. and actinomyces spp. after manual preparation of the cavity with an excavator and taking a sample for a microbial analysis with a rose bur on micro motor (size 014) the cavity undergoes the procedure of photodynamic disinfection: * application of photosensitizer 'fotosan agent' (cms dental, denmark) for 5 minutes, * radiation with low power laser, wavelength 635 nm power 200mw 120 s. ('lasotronix', diodelx model smart) * rinsing with water and drying after photodynamic disinfection another sample for microbial analysis is taken form the neighboring area to get the material for a comparison analysis. filling the cavity with a material for permanent fillings (glass-ionomer cement) samples are inoculated on: * mitis-salivarius ('difco') for streptococci * rogosa sl 2% aqar ('oxoid') for lactobacillus * columbia with blood for actinomyces (2 dilutions - 1:10 and 1:100)

Eligibility criteria:
inclusion criteria: * more than 10 teeth * at least one tooth with primary caries lesion with contraindicated non-invasive treatment (lesion which needs to be prepared and filled with material for permanent fillings); tooth with no clinical and/or radiological symptoms of pulp involvement. * no systemic disease exclusion criteria: * systemic diseases (may affect saliva flow and properties) * antibiotic therapy in previous 3 months before the appointment

Keywords: photodynamic therapy photoactivated disinfection primary root caries lesion cavity disinfection lasers root caries