Kornimate/medical-research-clean huggingface dataset:
the aging eye cohort study

Conditions: Eye Diseases

Summary: aging is a major risk factor for many blind-causing eye diseases, e.g., glaucoma, age-related cataracts, and age-related macular degeneration. with the population aging, the impact of lifestyle changes (less time spent outdoors, increasingly sedentary lifestyles, and unhealthy eating habits) on the eye health of the elderly needs further research. this study focuses on establishing a cohort of elderly subjects with normal vision and ocular structure at baseline. the main goal is to study the risk factors for common eye diseases in chinese elderly population while providing normal-controlled clinical and genomic data for other clinical studies on eye diseases.


Eligibility criteria:
inclusion criteria: 1. be able and willing to consent to the qualification and the follow-up phases of the study; 2. be able to undergo yearly examinations for ≥5 years; 3. age is older than 60 years; 4. best-corrected visual acuity of both eyes is better than 20/32; 5. intraocular pressure (non-contact tonometer) is between 10-21 mmhg; 6. except for mild cataracts, no other structural abnormalities of the eye are found. 7. have fundus photographs of adequate quality as assessed with a standardized protocol by the university of wisconsin fundus photograph reading center. exclusion criteria: 1. the presence of ocular disease in either eye, except for mild cataracts and ametropia; 2. previous retinal or other ocular surgical procedures (other than cataract extraction and capsulotomy); 3. a chronic requirement for any systemic or ocular medication administered for other diseases and known to be toxic to the retina or optic nerve; 4. cataract surgery within three months or capsulotomy within six weeks before the qualification visit; 5. any systemic disease with a poor 5-year survival prognosis.

Keywords: elderly population common eye disease risk factor genetics
prevalence of gynecological pathologies and use of hormonal treatments in women hospitalized for a venous thromboembolic episode

Conditions: Venous Thromboembolism

Summary: the incidence of venous thrombosis (venous thromboembolic disease: vte) in women of childbearing age in france is in the order of 0.3 to 0.5 / 1000 women / year. it is a rare disease, but the majority of events occurring in women of childbearing age are associated with a particular hormonal context (mainly pregnancy and hormonal contraception). vte is a multifactorial disease and the risk depends on the simultaneous presence of several triggers.

certain frequent gynecological pathologies are emerging in the literature as new venous thrombotic risk factors independently of hormonal treatment. indeed, in endometriosis, the prevalence of which is estimated to be around 10%, biological data are in favor of hypercoagulability. only one epidemiological study has analyzed this parameter. it is a japanese cohort study in 103,070 pregnant women including 77 vte during pregnancy. endometriosis and recurrent pregnancy loss (rpl) were identified as risk factors for vte (or: 2.70 (95%ci, 1.21-6.00) for endometriosis and 6.13 (95% 2.48-15.16) for rpl. in polycystic ovary syndrome (pcos), whose prevalence is estimated at 7-12%, the associated risk of vte is better known (or 1.89, 95%ci 1.60-2.24) and was the subject of a recently published meta-analysis in which the principal investigator collaborated. to the investigators knowledge, no study describes the prevalence of gynecological pathologies in women with vte. concerning hormonal contraception, estrogen-progestin contraception (epc) is widely used in france and is associated with an increase in the risk of vte of a factor of 3 to 6. after a venous thrombotic episode, epc is contraindicated, and non-hormonal or progestin-only contraception (poc) can be used. nevertheless, to date, few studies have focused on the management of hormonal contraceptive treatment at the time of a vte episode. moreover, the contraceptive options presented to patients are often based on multiple actors (vascular physicians, gynaecologists, midwives, general practitioners, etc.) and the experience of the vte episode, for both patients and prescribers, may influence the contraceptive options proposed or chosen, as well as their compliance.

Eligibility criteria:
inclusion criteria: * women aged 18 to 50 years hospitalized at saint joseph hospital between 01/01/2016 and 12/31/2020 for vte * icd-10 codes i26, i80, i82, o22.3, o22.5. exclusion criteria: * patient under guardianship or curatorship * patient deprived of liberty * patient under court protection * patient objecting to the use of his or her data for this research.
intravitreal and intracameral dex in npdr

Conditions: Non-Proliferative Diabetic Retinopathy

Summary: to investigate the effects of intravitreal and intracameral injection of dexamethasone during cataract phacoemulsification in patients with mild to moderate non-proliferative diabetic retinopathy

the study aims to analyze the impact of intravitreal and intracameral dex in diabetic patients with npdr who are undergoing phacoemulsification surgery. specifically, the investigators will investigate its effects on postoperative macular central thickness, the development of dme, and the progression of dr.

Eligibility criteria:
inclusion criteria: type 2 diabetic cataracts patients who were diagnosed with mild to moderate npdr exclusion criteria: -

Keywords: non-proliferative diabetic retinopathy cataract phacoemulsification cystoid macular edema
the safety and efficacy of 5% lidocaine patch and flurbiprofen patch for relieving acute low back pain

Conditions: Acute Back Pain

Summary: this is a prospective, randomized, single blinded, two-arm, head to head study. the purpose of this study is: * to evaluate and compare the efficacy of 5% lidocaine patch and flurbiprofen patch for treatment of acute low back pain. determining the effect of the 5% lidocaine patch and flurbiprofen patch for improving functional disabilities and in reducing pain resulting from acute low back pain. efficacy will be determined by the level of pain relief (as measured by the numerical rating scale, nrs), decrease in analgesics, improved quality of life (as measured by the oswestry disability questionnaire, odq, and core outcome measures index questionnaire, comi), pain interference with function (as measured by the brief pain inventory-interference scale, bpi-qol), short-form mcgill pain questionnaire-2(sf-mpq-2), general health status (as measured by the eq5d), overall treatment effect (ote), physical exam from baseline up to 1-months.


Eligibility criteria:
inclusion criteria: * all subjects underwent a detailed history and systemic physical examination including neurologic and musculoskeletal evaluations. to rule out any confounding etiologies, basic diagnostic laboratory tests including complete blood count and acute phase reactants (erythrocyte sedimentation rate and c-reactive protein) were performed. the patients diagnosed as having acute non-specific low back pain according to history and physical examinations were invited to participate and will be informed about the purpose and course of the study. main inclusion criteria * a primary complaint of pain in the area between the 12th rib and buttock crease without leg pain * female or male, 20 - 80 years of age * low back pain of less than six weeks' duration; and at least moderate pain intensity (nrs≧4) exclusion criteria: main exclusion criteria: * known or suspected serious spinal pathology and spinal implants * lumbar spinal surgery within the preceding six months * serious comorbidities preventing prescription of paracetamol * alternative treatment for low back pain in previous two weeks * chronic neurological lesion * chronic musculoskeletal lesion * active cancer * pregnancy * use of pain medication (except paracetamol) within 3 days * treatment site has active skin lesion or inflammation * known allergy to skin patch

Keywords: lidocaine patch flurbiprofen patch acute back pain
taping to control edema in patients with forearm plaster for wrist fracture.

Conditions: Edema Arm; Fracture; Wrist

Summary: wrist fractures are a very common event affecting patients of all ages and are estimated to account for approximately 10% -25% of all fractures. 70-90% of fractures are treated with closed reduction and forearm cast. in 2019, 17.4% of wrist fractured patients treated with a plaster cast at the orthopedic emergency department (oed) of the local health unit ("azienda unità sanitaria locale", ausl) of piacenza had a second access to the oed for edema, pain or "intolerance to the plaster cast ". in literature, there are several studies that demonstrate the effectiveness of adhesive elastic tape for edema control, mostly lymphedema secondary to breast cancer or post-operative edema after knee arthroplasty, although a definitive evidence is still needed. with this trial, the investigators aim to evaluate the tape effectiveness in counteracting hand edema formation in wrist fractured adult patients treated with forearm cast.


Eligibility criteria:
inclusion criteria: * patients with growth plates closed on radiographic examination * unilateral distal radius fracture associated or not with ulnar styloid fracture * wrist fracture requiring bloodless reduction and immobilization with a forearm cast exclusion criteria: * patients with multiple fractures * polytrauma patients * patients with previous plegia / paralysis of the fractured limb * patients with previous lymphedema of the fractured limb * patients with access to the oed during the night when the organization does not guarantee the presence of 2 nurses * wounds or abrasions in the area of application of the tape * acute thrombosis (upper limb veins) * scars not perfectly healed in the area of application of the tape * dermatitis, psoriatic manifestations or erythema in the area of application of the tape * known allergy to acrylic (patch glue) * solid neoplasms

Keywords: tape forearm cast
sbrt for extra-cranial oligorecurrent tumor

Conditions: Recurrent Cancer

Summary: clinical experience has shown that metastasis can often be limited in number and location, and thus amenable to local treatment. the term oligometastasis describes an intermediate state of cancer spread between localized disease and widespread metastasis. the implication of such an intermediate state is that the disease can be cured by using metastasis-directed therapy. historically, in some patients with oligometastases in the liver or lungs, surgical resection was often indicated, as abundant evidence suggested it could improve progression-free or overall survival. recently, several studies have reported promising outcomes of \>80% local control with stereotactic body radiotherapy (sbrt) in patients with lung or liver oligometastases. nonetheless, very few studies have focused on non-liver, non-lung extracranial oligometastatic lesions treated with sbrt, and such studies have limitations of a retrospective nature and small sample sizes.because allmost studies are based on single-arm studies without appropriate controls, the level of evidence to support sbrt is weak. randomized trials are therefore necessary to establish the utility of sbrt for oligometastatic disease. this study is designed as a randomized phase ii study. patients will be randomized between current standard treatment (arm 1) versus standard treatment +sbrt (arm 2) to all known disease.


Eligibility criteria:
inclusion criteria: * age \<18 years old * ecog score: 0-2 * number of distant metastases: 1-5 * all cancers (except lymphoma, myeloma, and germ cell tumor) * status of primary lesion: cured * pathologically confirmed cancer * life expectancy: over 6 months exclusion criteria: * recurrent lesion which had been treated by radiotherapy * complete response after systemic therapy * patients who cannot be treated with sbrt due to any reason. * pregnancy or breast-feeding * malignant pleural effusion

Keywords: stereotactic body radiotherapy
pros and cons of botulinum injection treatment in cerebral palsy

Conditions: Cerebral Palsy; Botulinum Toxin

Summary: the aim of this study is to quantitatively record the opinions regarding the pros and cons of this treatment of the caregivers of children with cerebral palsy who had botulinum toxin applied in investigators' clinic.

spasticity is defined as an increase in physiological resistance of the muscles associated with a lack of supraspinal inhibition against passive strain. it is a common and prohibitive problem associated with an increase in tendon reflex and tension reflex associated with upper motor neuron dysfunction. one of the most common problems in patients with cp. methods used in the treatment of spasticity; medical therapy, physical therapy, intrathecal baclofen pump, botulinum toxin injection, and orthopedic correction operations. however, botulinum toxin type-a (btx-a) injections, which are applied to the muscles especially for localized spasticity, have become an effective adjuvant option that increases the effectiveness of classical methods and diversifies the treatment options. btx-a, which is basically a chemodenervation method; it is a treatment method that blocks the transmission of signal in the neuromuscular junction by preventing the release of acetylcholine vesicles into the presynaptic space. in spastic muscles, relaxation can be achieved by correct injection. botulinum toxin type a has been shown to be an effective and safe treatment for children to reduce spasticity. in turkish society, there is no study evaluating the caregivers' experiences and opinions about botox treatments of patients with the diagnosis of cerebral palsy and limited studies in the literature are from countries with different sociodemographic features such as the united states and the united kingdom. although these patients have been receiving this treatment in investigators' center for years, there is no study in the literature that evaluates the plus and minus aspects of caregivers' experiences in this regard.

Eligibility criteria:
inclusion criteria: * to be the caregiver of a patient under 18 years old with cerebral palsy * no attempt has been made to reduce spasticity such as botulinum toxin injection in the last 3 months. exclusion criteria: * not knowing turkish * refusing to participate in the study.

Keywords: botulinum toxin cerebral palsy experiences spasticity caregivers
resolution of type 2 diabetes mellitus: intensive vs. conventional glycaemic control after obesity surgery

Conditions: Type 2 Diabetes Mellitus; Obesity

Summary: obesity surgery is very effective in improving or even curing type 2 diabetes in patients with obesity. many patients stop or reduce their medication after surgery and this can happen fairly quickly. the investigators do not know whether strict control of blood glucose/sugar after the operation makes any difference in the long term. additionally many patients prefer their blood sugars to be a "bit high" because they are afraid of hypos.a number of studies have described patients whose eye, nerve and kidney disease has deteriorated when high sugars are controlled very quickly. the investigators want to ensure that surgery provides maximum benefit and remains safe in patients with diabetes. this study will help us decide if the investigators should be strict with blood glucose after obesity surgery operations or not and whether obesity surgery is safe for the eye, nerve and kidney complications of diabetes.

subjects would be randomised into intensive glycaemic control and conventional glycaemic control after obesity surgery. data on complications of diabetes such as eye, nerve and kidney will be collected before obesity surgery and 1 year after surgery.

Eligibility criteria:
inclusion criteria: * patients with type 2 diabetes mellitus who have been approved for obesity surgery exclusion criteria: * patients with type 2 diabetes mellitus who do not require insulin immediately after obesity surgery

Keywords: type 2 diabetes mellitus obesity bariatric surgery glycaemic control microvascular complications intensive conservative
clinical evaluation of the antidepressant effect of the use of probiotics in bipolar disorder

Conditions: Bipolar Disorder

Summary: bipolar disorder (bd) is highly incapacitating and associated with premature mortality. depressive symptoms and episodes are the most frequent cause of disability in subjects with bd and over half of patients do not respond adequately to approved treatments for this condition, showing the need for new classes of treatments to complement current pharmacotherapy. previous studies demonstrated that the intestinal flora have potential positive or negative effects on the central nervous system and suggest that adding specific strains of bacteria to people's diet may have antidepressant properties.the study proposes to evaluate the clinical benefit of adding probiotics to pharmacological treatments for bipolar depression. this will be a study with 84 subjects (42 receiving probiotics and 42 placebo). the research team in this department has focused especially on non-pharmacological treatments for bipolar disorder (psychotherapy, nutrition and exercise) and is multidisciplinary in scope with psychiatrists, psychologists, nurses, physiotherapists and nutritionists participating in research projects.

it will test, in a proof-of-concept study, the antidepressant efficacy of adjunctive administration of probiotics in bipolar depression and evaluate potential inflammatory and metabolic markers associated with response to treatment. with this objective, 84 individuals with bipolar disorder type i or type ii presenting subsyndromal depressive symptoms or a major depressive episode will be recruited. the study design lasts 12 weeks and is expected to last two years.

Eligibility criteria:
inclusion criteria: * bd type i or type ii, according to the use of mini internacional neuropsychiatric interview (mini) * score on the young mania rating scale (ymrs) \< 8 * score on the montgomery-asberg depression rating scale (madrs) \> 8 * be receiving major guideline-approved treatments for bipolar depression for at least 4 weeks exclusion criteria: * pregnant or lactating women * substance or alcohol dependence * patients on prolonged antibiotic therapy, immunosuppressive therapies * a recent introduction of antidepressants in the last 15 days * use of another probiotic, either in the form of food, sachets, capsules and others
prevalence of cesarean section niche in women with unexplained abnormal uterine bleeding

Conditions: Cesarean Section; Dehiscence; Abnormal Uterine Bleeding

Summary: prevalence of cesarean section niche in women with unexplained abnormal uterine bleeding

prevalence of cesarean section niche as diagnosed by office hysteroscopy and transvaginal sonography in women with unexplained abnormal uterine bleeding

Eligibility criteria:
inclusion criteria: patients with a history of cesarean section who are complaining of abnormal uterine bleeding with the following criteria : * normal complete blood count apart from paramaters of anemia * not using drugs affecting coagulation profile * bleeding is not related to pregnancy * not using intrauterine contraceptive devices or hormonal contraceptives * by ultrasonography : no abnormalities in the pelvis e.g benign or malignant tumors , ovarian cysts or tumors * no evidence of cervical abnormalities as cause of bleeding with cervical examination or cervical smears exclusion criteria: * any patient not fulfilling the inclusion criteria * if the patient refused the technique ( office hysteroscopy )

Keywords: hytsteroscopy
the effect of the motivational interviewing technique on breast and cervical cancer screenings

Conditions: Menopause; Cervix Cancer; Breast Cancer

Summary: this study will be conducted to evaluate the effect of the motivational interviewing technique applied to menopausal women on their participation in breast and cervical cancer screenings. this is a randomized controlled intervention study in which the study sample will consist of 120 menopausal women, who visit the health care centers in the city of kutahya. there will be one intervention group with a total of 60 participants and a control group with the same number of participants. the intervention group will have motivational interviews whereas the control group participants will follow the normal protocols.

this study will be conducted to evaluate the effect of the motivational interviewing technique applied to menopausal women on their participation in breast and cervical cancer screenings. this is a randomized controlled intervention study in which the study sample will consist of 120 menopausal women, who visit the health care centers in the city of kutahya. there will be one intervention group with a total of 60 participants and a control group with the same number of participants. the intervention group will have motivational interviews whereas the control group participants will follow the normal protocols. the turkish version of champion's health belief model scale and the health belief model scale for cervical cancer and the pap smear test will be applied to all the participants in both groups. then for the intervention group, the motivational interviewing will be carried out in 3 different sessions, each to be conducted one week apart. 6 weeks after the last interview, first follow up would be conducted through phone communication and 6 weeks after the first follow up, a face-to-face interview would be conducted for the scales to be applied to the participants again. for the control group, the scales will be applied for the second time at the same time as the intervention group and they will be given a training manual and their questions will be answered by the researchers.

Eligibility criteria:
inclusion criteria: * visiting any family health centers in the city of kütahya, * without any cancer diagnosis and treatment, * not having had a clinical breast examination in the last 1 year, with no natural menstrual period in the last 1 year, have entered menopause and are 69 years old (included) maximum, * without a mammogram in the last 2 years in women who have gone through menopause and are 69 years old (included). * without an hpv or pap smear test in the last 5 years in women who have entered menopause and are in the age range of 65 (including), * being literate, * able to communicate. exclusion criteria: * having been diagnosed with any cancer, * inability to communicate, * failure to continue the phases of the study for any reason.