Kornimate/medical-research-clean huggingface dataset:
excision versus preservation of spermatic cord lipoma detected during subinguinal varicocelectomy

Conditions: Male Infertility

Summary: in the current study, the adult infertile patients with clinical varicoceles will be included. the patients will undergo subinguinal varicocelectomy. the patients with spermatic cord lipoma detected at the time of surgery will be enrolled and divided into 2 groups( excision group, group a and preservation group (b). semen parameters will be compared in both group at 3 and 6 months after surgery

this will be a prospective randomized study, in which adult infertile patients with clinical varicocele and oligo-athenospermia admitted to urology department tanta university hospital will be included and then the patients with detected spermatic cord lipoma at the time surgery will be enrolled and divided into 2 groups: group a : will undergo subinguinal varicocelectomy with excision of spermatic cord lipoma group b : will undergo subinguinal varicocelectomy with preservation of spermatic cord lipoma inclusion criteria: * adult infertile males * clinical varicocele * oligo-asthenospermia exclusion criteria: * adolescent varicocele * recurrent varicocele * presence of inguinal hernia * azospermic patients

Eligibility criteria:
inclusion criteria: * adult infertile males * clinical varicocele * semen analysis show oligo-athenospermia exclusion criteria: * adolescent varicocele * recurrent varicocele * presence of inguinal hernia * azospermic patients
virtual reality in aphasia telerehabilitation

Conditions: Aphasia, Acquired

Summary: the main purpose of this study is to evaluate the use of the immersive 3d hmd vr technology in the language intervention with a home-based telerehabilitation approach for people with aphasia. the assessments will be conducted at the baseline (prior the intervention periods) and after each intervention period (i.e. after the vr-intervention period and the waitlist period).

the purpose of the present project is to study the effects, feasibility, and the participants' experiences of this novel kind of language intervention. the effects of the intervention will be studied with various outcome measures in terms of language performance, functional communication, and quality of life. the aim is to explore the vr-intervention on the group level and with a randomized waitlist control group design (or delayed crossover design). in this study, the people with aphasia will be practicing at their home with support of their relatives, and participants will also receive regular remote guidance by a speech and language therapist (slt) during the intervention. the relatives are also involved in the assessment process.

Eligibility criteria:
inclusion criteria: * post-stroke aphasia ≥ 3 months from stroke * age 18-75 years * finnish as a native language * relative have the motivation and willingness to support person with aphasia in rehabilitation process * at least some level of spoken output * moderate-to-severe aphasia * deficit in a word retrieval process exclusion criteria: * participation in other intervention study during the study * participation in other traditional speech and language therapy during the vr-intervention (i.e. 9-10 weeks period). * severe and current psychotic disorder * dementia/other neurodegenerative disease * history of previous stroke (/strokes) if not recovered, excluding tias (the criteria for the recovery: no residual aphasia or other disabilities caused by stroke which would affect in significant manner on everyday life) * active epilepsy / migraine (\< 3 years) * severe apraxia of speech * inability to act according to given instruction * severe neuropsychological disorder or the decline of cognitive / memory functions, which would significantly affect for training during the vr-intervention * vision or hearing impairment which would prevent the use of vr hmd * if the participant's treatment or medication is unsuitable with the use of vr hmd device as assessed by the physician * if the participant has the pacemaker or implantable (electric) medical device

Keywords: aphasia, virtual reality, head-mounted device, rehabilitation, telerehabilitation
transection of sternothyroid muscle increases the rate of exposure of the external laryngeal nerve during thyroidectomy

Conditions: Thyroid; Surgery; Thyroid Disease

Summary: the sternothyroid (st) muscle is closely adherent to the thyroid gland with oblique insertion into the thyroid cartilage. ebsln passes through the sternothyroid laryngeal triangle with a parallel course deep to the st muscle. this study evaluates the transection of the sternothyroid muscle as a key step during thyroidectomy to increase the rate of exposure and visual identification of ebsln compared to st muscle retraction as a traditional technique.

the study was conducted on patients eligible for total thyroidectomy, which meets the standard of the ata thyroid guidelines. preoperative biochemical thyroid function tests and neck ultrasound with fnac of suspicious nodules confirmed the clinical diagnosis. patients who had previously undergone neck surgery or irradiation or were preoperatively diagnosed with a vocal cord movement disorder, a vocal cord benign lesion, or speech disorders were excluded from the study. a random number was used to determine the patient group allocation. data about patients were gathered via history, examinations, and investigations. the patients were randomized (computer-generated) with the use of an opaque-sealed envelope into two groups; group a: conventional method of thyroidectomy with st muscle retraction, group b: transection of st muscle. the study's primary endpoint was the identification rate of the ebsln in both techniques. the secondary endpoints included: a comparison of operative time in both techniques as well as anatomical variability of the ebsln according to cernea classification, rate of injury of ebsln, and changes in postoperative voice performance.

Eligibility criteria:
inclusion criteria: * eligible for total thyroidectomy * no previous history of neck surgery or radiation * no vocal cord pathology * no voice disorders exclusion criteria: * not fit for surgery * previous history of neck surgery or radiation * vocal cord pathology * vocal cord movement disorders
evaluation of clinical and radiographic outcomes of surgically treated multiligamentous knee injuries

Conditions: Knee Ligament Injury; PCL - Posterior Cruciate Ligament Rupture; PROMs

Summary: multiligament knee injuries are typically caused by high-energy mechanisms and are classified according to the number of ligaments involved using schenk's classification (knee dislocation) into kd 1, kd 2, kd 3, and kd 4. these types of injuries can have devastating consequences on the individual's quality of life, affecting their ability to return to sports and perform daily activities. in the literature, there is still no consensus on the management of these types of traumas, both due to the wide range of situations that can present to the orthopedic surgeon and the difficulty in their diagnostic and therapeutic framing. the main controversies concern the conservative or surgical management of the injuries and the timing of when to undertake surgical treatment, if at all. the instability resulting from multiligament knee injuries is poorly tolerated by patients, who find their daily activities limited. it is also well known that this instability can dramatically accelerate the development of osteoarthritis, leading to the need for joint replacement surgery even in young individuals, thus increasing the likelihood of revisions and re-operations over time. due to the lack of standardized and satisfactory treatment, the economic cost of the outcomes of multiligament knee injuries is particularly high. a recent study by xxx showed that only xxx% of individuals are able to return to work. the rate of participation in sports is even lower, which has a long-term potential impact by increasing the risk of sedentary lifestyle-related diseases such as obesity, diabetes, and cardiovascular diseases. the choice of surgical treatment aims to eliminate the patient's subjective feeling of instability and to repair, when possible, or reconstruct the injured ligament structures to reduce the risk of secondary osteoarthritis. available studies in the literature are often case reports presenting short- and medium-term results of non-standardized surgical techniques with great heterogeneity in rehabilitation protocols, so the real long-term effectiveness of these treatments in terms of joint stability and osteoarthritis prevention is not known.


Eligibility criteria:
inclusion criteria: 1. patients aged between 18 and 65 years at the time of surgery 2. male and female gender 3. patients undergoing multiligamentous knee reconstruction from january 1, 2000, to december 31, 2019, at the rizzoli orthopedic institute. exclusion criteria: 1. patients no longer reachable; 2. patients who do not consent to be included in the study; 3. pregnant women; 4. presence of infection or hematologic, rheumatic, or coagulative disorders at the time of evaluation.
renal denervation in heart failure with preserved ejection fraction

Conditions: Cardiac Failure

Summary: the purpose of this study is to determine whether renal sympathetic denervation (rsd)(a treatment that lowers the activity of the sympathetic nervous system) is useful in the management of patients with heart failure with preserved ejection fraction (hf-pef).

increasing evidence suggests an important role of activation of the sympathetic nervous system (sns) in heart failure with preserved left ventricular ejection fraction. the current study aims to evaluate efficacy of renal sympathetic denervation for the modulation of the sns in patients with hf-pef.

Eligibility criteria:
inclusion criteria: * ef\>40% * nhya 2-3 * evidence of hf-pef (mixture of dilated left atrium, left ventricular hypertrophy, raised e/e', elevated lvedp/pcwp, raised bnp) exclusion criteria: * previously documented ef\<40% * hypertrophic, restrictive, dilated cardiomyopathy * significant valvular heart disease * unfavourable renal artery anatomy for renal denervation * egfr\<45 * contraindication to mri * myocardial infarction, unstable angina or cerebrovascular accident in last 3 months

Keywords: cardiac failure autonomic denervation
compass device cvc trial

Conditions: Blood Pressure

Summary: this is a single-arm observational trial of a device (compass vascular access, centurion medical products, williamston mi). the device is a compact, sterile, single-use extravascular blood pressure transducer. this pressure measurement aids in confirmation of appropriate venous access. the investigators plan to enroll 40 consenting patients with bmi ≥35 who require central venous catheterization for clinical reasons independent of the existence of this study. the primary outcome is operator satisfaction.

forty (40) consenting patients meeting inclusion/exclusion criteria for this single-arm observational trial will be prepared as usual for central venous catheter (cvc) placement. the compass pressure measurement device will be included in the cvc placement apparatus as per the manufacturer's directions. data will be recorded on the placement procedure, operator satisfaction, routine patient demographics, and incidence of inadvertent arterial puncture.

Eligibility criteria:
inclusion criteria: * bmi ≥35 exclusion criteria: * pregnant women * adults unable to consent * non-english speakers * prisoners

Keywords: operator satisfaction with device
emotion and symptom-focused engagement (ease): an intervention for individuals with acute leukemia

Conditions: Acute Leukemia

Summary: the purpose of this study is to test the feasibility of an individual psychological and physical symptom intervention, called emotion and symptom-focused engagement (ease), to reduce traumatic stress and physical symptom burden in individuals newly diagnosed with acute leukemia.

this study involves the pilot-testing of a newly developed, brief manualized individual psychotherapy and physical symptom control intervention, called emotion and symptom-focused engagement (ease), to reduce traumatic stress and physical symptom burden in individuals newly diagnosed with acute leukemia. the purpose of this study is to conduct a two-arm randomized pilot trial (rpt) to test the feasibility, acceptability, and preliminary efficacy of ease against usual care (uc) for the reduction of traumatic stress and physical symptom burden in patients with acute leukemia. usual care for individuals with acute leukemia treated at the princess margaret cancer centre includes referral for non-standardized, and primarily instrumental, psychosocial care and palliative care service as needed. the design will be an unblinded rpt consisting of two conditions (ease and uc), with a baseline assessment and follow-ups at 4, 8, and 12 weeks. the trial will take place at the princess margaret cancer centre, university health network; a comprehensive cancer center in toronto, canada. participants will be newly diagnosed with acute leukemia, within one month of diagnosis and/or admission to hospital for treatment with curative intent.

Eligibility criteria:
inclusion criteria: * new or relapsed diagnosis of acute leukemia (an amendment to allow recruitment of relapsed patients was approved on 24-sep-2015, although no relapsed patients were ultimately recruited) * will be receiving induction chemotherapy with curative intent and within 1 month of diagnosis and/or admission to hospital at the princess margaret cancer centre * age ≥ 18 years * fluency in english * no cognitive impairment indicated in the medical record, communicated by the hematology clinical team, or determined by research staff at recruitment. exclusion criteria: * inability to pass the cognitive screening test (short orientation-memory concentration test \[somc\] score \<20) * actively receiving psychological/psychiatric counseling or palliative care services from the department of psychosocial oncology and palliative care (popc), now called the department of supportive care, at the princess margaret cancer centre at the time of recruitment to this study

Keywords: acute leukemia traumatic stress quality of life symptom burden psychosocial oncology palliative care intervention hematological malignancies supportive care
development of clinical pathways to the diagnosis of heart failure with preserved ejection fraction

Conditions: Heart Failure With Preserved Ejection Fraction (HFpEF)

Summary: prevalence of heart failure with preserved ejection fraction (hfpef) continues to increase in the developed world, likely because of the increasing life expectancy and an increasing number of elderly patients. transthoracic echocardiography is essential for the diagnosis of hfpef according to the current guidelines. the hfa-peff and h2fpef diagnostic algorithms rely on clinical characteristics and echocardiography findings that indicate the presence of diastolic dysfunction. these diagnostic algorithms are not applicable in remote areas where expert echocardiography cannot be performed due to the absence of modern ultrasound systems and lack of qualified specialists. therefore, it is important to develop an algorithm to evaluate pre-test probability of hfpef without echocardiographic markers, so it can be easily used in the primary outpatient care setting by any specialist. the aim of this study is to find the associations between clinical and epidemiological characteristics and changes of intracardiac hemodynamics in patients with dyspnea and decreased exercise tolerance.


Eligibility criteria:
inclusion criteria: * adult patients complaining of shortness of breath, with two or more chronic non-communicable diseases (patients with comorbidities) exclusion criteria: * morbid obesity; * any chronic diseases in the stage of exacerbation and / or decompensation; * systemic diseases, cancer; * cardiac arrhythmias: persistent atrial fibrillation or paroxysmal atrial fibrillation with frequent paroxysms; * history of myocardial infarction, stroke, heart failure with reduced ejection fraction; * storage diseases, hypertrophic cardiomyopathy, concentric hypertrophy; * congenital and acquired heart defect;
reiki effects on pain, functional status and holistic well-being in patients with knee osteoarthritis

Conditions: Knee Osteoarthritis; Pain

Summary: this study aimed to examine the effect of reiki therapy on pain, functional status and holistic well-being in patients with knee osteoarthritis.

knee osteoarthritis is a chronic degenerative joint disease that causes pain in individuals and negatively affects their functional status and overall well-being. patients often benefit from non-pharmacological methods in pain control. reiki, expressed as "universal life energy", is a kind of energy therapy that creates the appropriate conditions required by the body's natural healing system in rebalancing and recharging human energy fields. although reiki studies in the field of orthopedics are limited, it is revealed that reiki improves physical function, reduces fatigue and increases emotional well-being in rheumatoid arthritis patients. studies evaluating the effectiveness of reiki in patients undergoing total knee replacement have evaluated that reiki is effective in controlling postoperative pain, reducing blood pressure, respiratory rate, and state anxiety. the study was conducted with patients with knee osteoarthritis who applied to the orthopedic outpatient clinic of a training and research hospital between june 24, 2022 and december 31, 2022. the data of the study was collected using "patient information form (pif)", "visual analog scale (vas)", "western ontario and mcmaster universities osteoarthritis index (womac)" and "holistic well-being scale (hws). pif, vas, womac and hws were applied to the patients who met the inclusion criteria and agreed to participate in the study. patients were randomized 1:1 into groups by a single therapist according to the block randomization method. there were two arms in the study; reiki treatment (n=21) and control group (n=21). a second-degree reiki practitioner applied reiki to the patients for 40 minutes. on the second day and the third day, 30 minutes distant reiki were applied to the patients. in the control group, nothing was done. post-tests were applied to all patients 3 days and 10 days after they were included in the study.

Eligibility criteria:
inclusion criteria: * grade 2-3 osteoarthritis according to the kellgren lawrence scale, * patients aged 40 and over exclusion criteria: * those who have difficulty in responding to the data collection form to be used in the research and have problems in understanding and communicating turkish, * those who refuse to answer the reiki application and data collection tools, * those who want to leave at any stage of the research or cannot be reached by phone, * those who underwent an application such as physical therapy, intraarticular injection or prolotherapy during the research process, * those who used any complementary and alternative method (cam) in the last 6 months were excluded from the study.

Keywords: reiki functional status pain knee osteoarthritis
cd133+ autologous cells after myocardial infarction

Conditions: Acute Myocardial Infarction

Summary: title intracoronary injection of cd133+ autologous hematopoietic cells after myocardial infarction. trial design pilot phase i/ii parallel group study, with an untreated control group. sponsor irccs ospedale maggiore policlinico milano indication acute myocardial infarction (ami). target population patients (pts) with ami treated with primary coronary angioplasty (ptca) with successful recanalization but unsuccessful reperfusion (myocardial blush (mb) grade 0 or 1 and less than 70% st segment elevation resolution (ster) (see poli et al., circulation, 2002). objectives primary: 1. to evaluate the safety of intracoronary injection of cd133+ cells from autologous bone marrow (abm) and mobilized peripheral blood (mpb) in the target population. 2. to evaluate the efficacy, of the selective injection of cd133+ cells from abm and mpb in the culprit vessel of the target population, on regional and global contractile function and on perfusion and metabolism of the infarcted area, depending on cell dose and comparing to controls. secondary: 3. to evaluate the disease-related morbility of the target population.


Eligibility criteria:
inclusion criteria: * informed consent; * age: 18-65 years; * large acute myocardial infarction (due to proximal occlusion of the left anterior descending or the right coronary artery) after successful primary ptca carried out between the iv and the xxiv hour from the onset of ami symptoms; * signs of microvascular dysfunction in the infarcted area: absence of ster and angiographic mb, graded according to the dye density score (see van't hof et al., circulation, 1998); life expectancy more than 6 months. exclusion criteria: * pregnancy; * indication to aorto-coronaric by-pass; * neoplasia (previous or in progress); * primary diseases of the bm; * diabetes; * immunosuppressive therapy; * laboratory alterations of protein s, protein c, atiii or fibrinogen; * severe co-morbidity.

Keywords: cell therapy acute myocardial infarction
taxotere-enoxaparin-(enoxa)-study

Conditions: Non-small Cell Lung Cancer

Summary: taxotere-enoxaparin-(enoxa)-study: 1st-line docetaxel-platin chemotherapy as single therapy or in combination with enoxaparin in patients aged older than 18 years with locally advanced or metastatic non-small cell lung cancer (stadium iiib/iv), a phase iii study. study hypothesis: increase of progressive free survival from 5 to 7.5 months.


Eligibility criteria:
inclusion criteria: * signed informed consent * men and women aged 18 and older * locally advanced or metastatic non-small cell lung cancer stage iiib/iv without any previous therapy * life expectancy at least 12 weeks * eocg performance \< 1 * appropriate renal and hepatic function * appropriate hematology * no bleeding events within 4 weeks prior to randomization * no indication for prophylactic or therapeutic anticoagulation therapy * appropriate methods of contraception (both: men and women) for women of childbearing potential negative urine pregnancy test within 7 day prior to randomization * capability for s.c. injection of enoxaparin every 24 hrs exclusion criteria: * history of cancer other than nsclc * known contraindication for enoxaparin e.g. hit, * known contraindication for docetaxel, cisplatin, carboplatin or co-medication * participation in any other clinical trials within 30 days prior to randomization * any known medical condition that does not allow therapy according to study protocol * seizure disorder

Keywords: non-small cell lung cancer nsclc enoxaparin locally advanced or metastatic non-small cell lung cancer stadium iiib/iv