Kornimate/medical-research-clean huggingface dataset:
efficacy of robot-assisted rehabilitation of hand paralysis after stroke

Conditions: Stroke

Summary: among robotic devices, gloreha, with its compliant mechanical transmission, may represent an easily applied innovative solution to rehabilitation, because the hand can perform grasp and release activities wearing the device by mean of a flexible and light orthosis. our objective on this research was to the robotic assisted motion and activity in additional to physiotherapy (pt) and occupational therapy (ot), on stroke patients with hand paralysis.

the investigators evaluated the effectiveness of a robotic-assisted motion and activity in additional to physiotherapy (pt) and occupational therapy (ot), on stroke patients with hand paralysis. a randomized controlled trial. the experimental group received a passive mobilization of the hand through the robotic device gloreha and control group received a pt and ot for 3 consecutive weeks (3 days/week) in addition to traditional rehabilitation. outcomes included the national institutes of health stroke scale (nihss), modified ashworth scale (mas), barthel index (bi), motricity index (mi), short version of the disabilities of the arm, shoulder and hand (quickdash), and the visual analogue scale (vas) measurements. all measures were collected at baseline and end of the intervention (3 weeks).

Eligibility criteria:
inclusion criteria: * acute phase of stroke * first stroke episode. * no history of peripheral nerve injury or musculoskeletal disease * no contracture of the affected wrist or fingers (modified ashworth\<3) * no history of any invasive procedure (botulinum toxin type a) for the treatment of spasticity for at least 6 months prior to the start of this study. * paralysis of the wrist and fingers exclusion criteria: * unstable medical disorders, active complex regional pain syndrome (crps) severe spatial neglect, aphasia, or cognitive problems. * scored greater than 4 points on the beck depression inventory (bdi) * more than 30 points in the state trait anxiety inventory (stai)

Keywords: hand paralysis stroke
cabergoline versus calcium gluconate infusion in the prevention of ovarian hyperstimulation syndrome

Conditions: OHSS

Summary: the aim of this study is to compare the efficacy of calcium gluconate infusion versus cabergoline in the prevention of ovarian hyperstimulation syndrome (ohss) in patients pretreated with gnrh agonist long protocol who are at high risk for ohss.

ovarian hyperstimulation syndrome (ohss) is a serious complication of assisted reproduction. previous studies revealed that calcium gluconate infusion reduced the risk of ohss. other studies revealed that cabergoline (potent dopamine receptor agonist on d2 receptors)was effective in preventing ohss. the aim of this study is to compare the efficacy of calcium gluconate infusion versus cabergoline in the prevention of ovarian hyperstimulation syndrome (ohss) in patients pretreated with gnrh agonist long protocol who are at high risk for ohss.

Eligibility criteria:
inclusion criteria: * patients who are stimulated using the long luteal gnrh agonist protocol and at high risk for developing ohss \[have more than 18 follicles (\> 11mm) and serum estradiol ≥ 3000 pg/ml on the day of hcg administration\]. exclusion criteria: * fibrosis of lung * swelling or inflammation around the heart or lung * hypertension * liver disease * heart valve disease and allergy to cabergoline or ergot derivatives.

Keywords: ohss infertility cabergoline calcium gluconate ivf-et
determining whether multiple anesthesia exposures affect cognitive function for retinoblastoma patients

Conditions: Pediatric Retinoblastoma; Retinoblastoma

Summary: the purpose of this study is to see if there is a difference between the development of the brain (neurodevelopment) in children who have been treated for retinoblastoma with multiple anesthetic exposures, compared with brain development in children who have never had anesthesia.


Eligibility criteria:
inclusion criteria: * age ≥ 6 and \< 17 years old exclusion criteria: * diagnosis of any secondary disease associated with developmental delay * history of second cancer diagnosis * legal blindness * past surgery of any type, with the exception of enucleation for retinoblastoma * past exposure to anesthesia for purposes other than retinoblastoma examination * more than one anesthesia encounter before diagnosis at msk * past external beam radiation for treatment of retinoblastoma * past systemic chemotherapy * non-native speaker of english; however, children whose parents speak only spanish will be included, because the tests for parents are available in spanish

Keywords: 18-126 memorial sloan kettering cancer center
virtual reality glasses on applied during thyroid fine needle aspiration biopsy

Conditions: Thyroid Nodule

Summary: the effect of virtual reality glasses on applied during thyroid fine needle aspiration biopsy on anxiety level, pain intensity and patient satisfaction

beginning 1-2 minute before the start of the procedure, the patients will be watched (5-10 minutes) with an android mobile phone inserted into the cardboard super flex binoculars glasses.

Eligibility criteria:
inclusion criteria: * being over 18 years old * ability to communicate adequately * volunteering to participate in the research exclusion criteria: * those with psychiatric problems * being unconscious

Keywords: thyroid fine needle aspiration biopsy
mobile intervention for mental health of family caregivers in thailand

Conditions: Depressive Symptoms, Generalized Anxiety, or Psychological Stress

Summary: the goal of the r21 project is to develop a culturally informed caregiver mental health mobile application program that will promote early detection of mental health problems and deliver an evidence-based self-care intervention for family caregivers providing care to adults with chronic disease in thailand.

the goal of the 2-year r21 project is to develop a culturally informed caregiver mental health mobile application (hereafter referred to as camma) program that will deliver an evidence-based intervention to reduce mental health problems in family caregivers of adults with chronic disorders in thailand. specific aims include: 1) conducting qualitative research on family caregivers of persons with chronic disorders, focusing on their experience with mental health problems, caregiving practice, coping mechanisms, and socio-technological barriers to technology acceptance and use; 2) develop a mobile application for the delivery of the camma intervention; and 3) conduct a formative evaluation of the camma intervention components to ensure acceptability and usability of individual intervention components.

Eligibility criteria:
inclusion criteria: * adult (age 18 +) family caregiver (cg) * has a minimum of 4 months of experience as a caregiver and provides at least 4 hours a day of care to the care recipient (cr); * screen positive on depressive symptoms (score above 5 on phq-9), or generalized anxiety (score above 3 on gad-2), or stress measured with perceive stress scale (score above 6 on pps-4) * access to a mobile device with internet access exclusion criteria: * caregiver who refuses to provide informed consent
research in ethno-medicine and education (remed)

Conditions: Cervical Cancer; Human Papilloma Virus; HPV; Human Papillomavirus Infection

Summary: the purpose of this study is to gain information about intravaginal practices, like intravaginal "twalet deba", among haitian women living in south florida. intravaginal "twalet deba" may include douching, cleaning inside the vagina with different kinds of products, or using steam/vapor that enter the vagina. the investigators want to help learn the best way to increase early detection and/or prevention for cervical cancer. the investigators would like to know what plants, herbs, commercial products and medicines are used in these practices, how these products are prepared, applied, why these products are used, and how these products affect the vagina and cervix.


Eligibility criteria:
inclusion criteria: * 18 years of age or older * self-identifies as haitian or haitian-american * resident of miami-dade, broward or palm beach county * currently engages in regular intravaginal cleansing practices that involve more than just water alone * no history of hysterectomy * speaks creole or english exclusion criteria: * are adults unwilling or unable to provide consent * individuals less than 18 years of age * pregnant women * prisoners

Keywords: twalet deba
body composition assessment and smart-phone based counselling on healthy eating and weight management

Conditions: Weight Management; Healthy Diet

Summary: this study proposed an integrated multi-disciplinary approach including a professional and convenient body composition measurement and an immediate counselling after the measurement, followed by 6-month smart-phone based individualized counselling. we believe that this approach will promote healthy eating behaviors and weight management among middle-aged chinese in hong kong.

this is a two-arm, individual level, 6-month randomized controlled trial. the intervention group will receive convenient body composition measurement and 6-month smart-phone based individualized counselling. no specific intervention will be given to the control group except the common anthropometric and body composition measurement. a pretest-posttest evaluation and between-group comparison will be used to test whether the impact/success of the project has been achieved.

Eligibility criteria:
inclusion criteria: * able to understand cantonese and read chinese; * self-reported vegetable and fruit consumption is less than 5 servings per day (one serving means 125 ml (½ cup) fresh, frozen or canned fruits or vegetables; or 250 ml (1 cup) raw leafy veggies or salad; or 125 ml (½ cup) 100% juice; or 1 fruit; * reachable by smart-phone and familiar with the use of smart-phone; * would not move from the local area during the study period. exclusion criteria: * self-reported history of cardiovascular and pulmonary diseases, neurological disorder, musculo-skeletal disorder, osteoarthritis, and eating disorder; * receiving medically prescribed diet or physical activity intervention; * for women, currently pregnant; * have been taking any medications or long-term supplement such as herbs; * cannot provide written informed consent.

Keywords: body composition assessment smart-phone based counselling weight management health eating behavior middle-aged hong kong chinese
to evaluate the safety and efficacy of a new device in the management of mild to moderate atopic dermatitis in children

Conditions: Atopic Dermatitis

Summary: the purpose of this study was to evaluate the safety of the investigational study product and see how well it works to relieve signs and symptoms of children with mild to moderate atopic dermatitis (ad), also known as eczema, in comparison to that of a similar marketed product. this study was conducted to assess the safety of the investigational new study product and how well it works to treat ad in children, by making ad visually better, and reducing the amount of itch.

this was a multi-center, double-blind, randomized, active-controlled trial in children 2 to 12 years of age with mild to moderate ad. a sufficient number of subjects were screened to ensure that approximately 80 subjects were randomized, to yield 70 completed subjects. subjects were randomized to one of the two treatment groups: the j\&j device or atopiclair®. all subjects were to return to the clinical site for clinical assessments at baseline (day 1) and at days 3, 8, 15, 22, 29 and 43 after initial investigational product application. the investigational products were used topically during the duration of the study.

Eligibility criteria:
inclusion criteria: * post-menarchal female subjects must have a negative urine pregnancy test * willing to provide written informed consent/assent * diagnosed as having mild to moderate atopic dermatitis (ad) * willing to stop all moisturizers and/or other skin barrier cream or emulsion treatments for the ad condition during the test period and replace with the investigational product assigned in this trial * willing to replace their body wash and/or soaps with the one provided in this trial exclusion criteria: * severe ad as determined by the rajka-langeland severity index * ad requiring systemic, super-potent (class i) or potent (class ii or iii) topical corticosteroids. if the subject requires any of these medications as rescue therapy during the study, the subject will be discontinued from the trial * history of allergy or hypersensitivity to the ingredients of the test devices, nuts or nut oil * cutaneous or systemic viral (including hiv or aids), mycotic or bacterial disease requiring a topical or systemic therapy * diabetes mellitus that cannot be controlled by diet alone (i.e., requires systemic medications for control)

Keywords: eczema
metabolic screening in patients with donnai-barrow syndrome

Conditions: Donnai-Barrow Syndrome

Summary: this study focuses on the genetics and metabolism of donnai-barrow syndrome (dbs).

the purpose of this study is to better understand the role of certain nutrients and vitamins in promoting the healthy development of individuals with donnai-barrow syndrome. the investigators hope that the information gained by studying the metabolism of children with donnai-barrow syndrome and their family members will lead to significant advances in the treatment of this disease.

Eligibility criteria:
inclusion criteria: all individuals affected with donnai-barrow syndrome

Keywords: donnai-barrow syndrome (dbs) metabolic testing genes genetic
tissue factor pathway inhibitor (tfpi) and haemorrhagic manifestations in haemophilia a and b patients

Conditions: Hemophilia

Summary: haemophilia is a rare and serious congenital defect of blood coagulation due to a genetic mutation on a sexual chromosome. it affects quasi-essentially the men and it is responsible for bleeding. there are two types of haemophilia: haemophilia a, (85 % of cases), due to a factor viii (fviii) deficiency and haemophilia b (15 % of cases) due to factor ix (fix) deficiency. according to the intensity of the defect, there are three forms of haemophilia: severe (fviii or fix lower than 1 %), moderate (factor level between 1 and 5 %), minor (factor level between 5 and 40 %). for a same level of factor viii or ix, hemorrhagic manifestations are variable from one patient to the other. moreover, several studies showed that haemophilic b patients bleed less and consume fewer anti-hemophilic concentrate that haemophilic a patients. the main inhibitors of the coagulation are antithrombin, protein c-protein s-thrombomodulin system, and tissue factor pathway inhibitor (tfpi). tfpi is the specific and exclusive inhibitor of tissue factor pathway that is the main way by which plasmatic coagulation starts. tfpi is a potent direct inhibitor of factor xa and xa-dependent inhibitor of the viia-tissue factor (tf) complex. in hemophilic patient, the production of xa by the amplification pathway being strongly altered because of factor viii or ix deficiency, thrombin generation (via xa) comes exclusively from tfpi regulated tissue factor pathway. we can thus say that if haemophilic patients bleed, it is also because of the presence of tfpi that inhibits at the same time xa and the complex tf-viia as soon as factor xa is generated.


Eligibility criteria:
inclusion criteria: * haemophilia a and b patients between 18 and 65 years old, whatever the severity of their disease, who have signed the informed consent form * on-demand or on prophylactic therapy. * regular monitoring in investigator center. exclusion criteria: * - haemophilia patients under 18. * presence of an inhibitor at any time before or during the study period. * patients who received factor viii concentrate less than 72 hours or factor ix concentrate less than 96 hours before blood collection * patients who refused to sign informed consent * patient data over the last 5 years at least not available. * no regular monitoring in haemophilia center (required at least one visit every 18 months for severe or moderate hemophiliac patients).

Keywords: haemophilia tfpi thrombin generation hemorrhagic score
primary urethral realignment vs. suprapubic cystostomy for initial management of pediatric pelvic fracture urethral injury

Conditions: Urethral Injury

Summary: it is prospective randomized comparative clinical trial comparing primary urethral realignment vs. suprapubic cystostomy in initial management of pediatric pelvic fracture urethral injury regarding: 1. the success rate after initial intervention. 2. the need for urethroplasty in the failed realignment group and cystostomy group. 3. the success rate of urethroplasty in the failed realignment group and cystostomy group.


Eligibility criteria:
inclusion criteria: * male children less than 18 years presenting with pelvic fracture urethral injury exclusion criteria: * associated bladder neck injury. * associated rectal injury. * late presentation \>2weeks since trauma. * history of previous urethral intervention.
virtual care in pediatric asthma

Conditions: Asthma in Children

Summary: the purpose of this study was to determine the impact of virtual care for children with asthma on the disease management and quality of life of children with asthma.

after children were randomized by protocol number, they completed the child information form, the quality of life scale of the child with asthma, and the asthma control test at the first interview. pef meter and asthma diary were given at the first interview. children in the virtual care group received online training in four modules within the first month.the virtual group provided counseling services by phone and video conference for six months. the control group received the standard care provided in the clinic. asthma diary data were collected from both groups at the end of each month

Eligibility criteria:
inclusion criteria: * having a smartphone or tablet with internet connection, parents and patient willing to maintain a daily log of symptoms and medication use exclusion criteria: * children who had mental problems, had not attended at least one of the training and did not send at least one month of their asthma diary were excluded from the study.

Keywords: virtual care
safety and performance study of the edwards sapien 3 transcatheter heart valve/ the sapien 3 study

Conditions: Aortic Valve Disease

Summary: the purpose of this study is to assess the safety and device success of the edwards sapien 3 transcatheter heart valve (s3 thv) and the edwards commander and certitude delivery systems in patients with symptomatic, severe aortic stenosis who are indicated for aortic valve replacement.

this is a non-randomized, prospective, multicenter safety and device success study. two hundred fifty (250) patients are planned to be enrolled at up to 20 participating investigational centers in europe and canada. patient participation will last for a minimum of 5 years. patients will be assessed at the following intervals: baseline, hospital discharge, 30 days, 1 year and annually thereafter for a minimum of 5 years.

Eligibility criteria:
inclusion criteria: 1. severe symptomatic calcific aortic valve stenosis with: 1. high surgical risk: sts score ≥ 8 or euroscore ≥ 15 (first 50 patients), 2. high to intermediate surgical risk: sts score ≥ 4 or euroscore ≥ 10 (patients 51 to 150). 3. intermediate surgical risk: sts score 4 to 8 or logistic euroscore 10 to 15 (subsequent patients); except for 20mm valve implants (sts score \> 4 or euroscore ≥ 10). 2. age ≥ 75 years 3. nyha ≥ ii 4. heart team (including examining cardiac surgeon) agrees on eligibility including assessment that tavr is appropriate. 5. study patient has provided written informed consent to comply with all of the study procedures and follow-up visits. exclusion criteria: 1. non-calcified aortic valve 2. acute myocardial infarction ≤ 30 days before the intended treatment 3. untreated clinically significant coronary artery disease requiring revascularization. 4. aortic valve is a congenital unicuspid or congenital bicuspid valve. 5. mixed aortic valve disease (with predominant aortic regurgitation) 6. preexisting bioprosthetic valve or ring in any position 7. for intermediate risk patients enrolled under inclusion criterion 1.c) patients with untreated pre-existing conduction disturbances (av block and bundle branch block).

Keywords: transcatheter aortic valve replacement aortic stenosis
multimodal analgesia methods in patients undergoing ipack block in knee arthroplasty

Conditions: IPACK Block Multimodal Analgesia; Postoperative NRS Scores

Summary: a comparison of two pain control methods - the combination of adductor canal block (acb)/infiltration of the interspace between the popliteal artery and the capsule of the posterior knee (ipack) versus the periarticular injection (pai)/ infiltration of the interspace between the popliteal artery and the capsule of the posterior knee (ipack) - in patients undergoing total knee arthroplasty. dexketoprofen and paracetamol will be added to both groups and multimodal analgesia will be applied. primary outcome is nrs pain scores with ambulation on postoperative day one (24 hours post-block administration).

postoperative pain after total knee arthroplasty is serious and difficult to management. multimodal analgesia recommended for the pain management. for these reasons, we planned a study involving two multimodal analgesia regimens. patients who will undergo total knee arthroplasty will receive preemptive oral analgesic (dexketofrofen) 1 hour before the operation. surgery will be initiated after spinal anesthesia is applied to the patients. two pain control methods - the combination of adductor canal block (acb)/infiltration of the interspace between the popliteal artery and the capsule of the posterior knee (ipack) versus the periarticular injection (pai)/ ipack- will be applied at the end of the surgery. dexketoprofenand paracetamol will be added to both groups and multimodal analgesia will be applied. primary outcome is nrs pain scores with ambulation on postoperative day one (24 hours post-block administration).

Eligibility criteria:
inclusion criteria: * patients with osteoarthritis scheduled for a primary either partial or total knee arthroplasty with a participating surgeon * age 18 to 80 years * planned use of regional anesthesia * ability to follow study protocol * patients of participating surgeons exclusion criteria: * hepatic or renal insufficiency * younger than 18 years old and older than 80 * patients undergoing general anesthesia * allergy or intolerance to one of the study medications * bmi \> 40 * diabetes * asa of iv * chronic gabapentin/pregabalin use (regular use for longer than 3 months) * chronic opioid use (taking opioids for longer than 3 months, or daily oral morphine equivalent of \>5mg/day for one month)