Kornimate/medical-research-clean huggingface dataset:
wearable enhanced fitness tracking for metastatic breast cancer patients using endocrine treatment and palbociclib

Conditions: Breast Neoplasm Female; Quality of Life

Summary: combining a fitness tracker technology with real-time patient-reported outcome monitoring associated with interventions through a health care app is a novel strategy to evaluate metastatic breast cancer patients using palbociclib and endocrine treatment.

measure the quality of life of patients with metastatic breast cancer treated with palbociclib and endocrine therapy using the functional assessment of cancer therapy - breast and euroqol -5d - european quality of life in five dimensions and compare the group using the wecancer digital health app with the group using wecancer and the physical activity monitoring smartwatch.

Eligibility criteria:
inclusion criteria: * female patients ≥ 18 years of age diagnosed with hormone receptor-positive/ human epidermal growth factor receptor 2- negative metastatic breast cancer undergoing treatment with palbociclib combined with aromatase inhibitors (letrozole, exemestane or anastrozole) or fulvestrant as first-line therapy, or in treatment with palbociclib and fulvestrant as second-line or posterior-line therapy in the metastatic setting; may be using ovarian suppression if the patient is premenopausal. * the patient must be on treatment for at least three (3) months with palbociclib and endocrine therapy. * evidence of a signed and dated informed consent document, physically or digitally, indicating that the research participant was informed about all relevant aspects of the study; * the patient agrees not to participate in another study with drug intervention while on treatment. * have performance status according to the eastern cooperative oncology group * have access to a compatible smartphone and 3g or 4g internet connection exclusion criteria: * patients considered to be at poor medical risk due to uncontrolled serious medical disorder, non-malignant systemic disease, or active uncontrolled infection. examples: uncontrolled ventricular arrhythmia, recent myocardial infarction (within 6 months), stroke, gastrointestinal bleeding, or any psychiatric disorder that precludes informed consent; between others. * patients who have a life expectancy of \< 3 months. * treatment with any product under investigation during the last 28 days; * another acute or chronic medical or psychiatric condition or severe laboratory abnormality that could increase the risk associated with participation in the study or that page 10 de 21 version 6.0 could interfere with the interpretation of the study results and, in the investigator's judgment, would make the research participant unsuitable for inclusion in the study. study. * illiterate patients or those with a low level of education that may prevent the correct use of the wecancer application and/or the watch with monitoring of physical activity.

Keywords: quality of life metastatic breast cancer metastasis exercise palbociclib
anterior defect correction with mesh plus treatment of stress incontinence with transobturator or transvaginal approach

Conditions: Cystocele; Stress Urinary Incontinence

Summary: the incidence of anterior pelvic defect in women is estimated about 10% and it may be often associated to urinary stress incontinence. to date the correction of anterior defects with the use of graft material inserted with transobturator approach has become of large use. moreover, given the frequent association of urinary stress incontinence to anterior defect, in most of cases it becomes necessary to perform at the same time an anti-incontinence procedure, i.e. a sub-urethral sling positioning. based on these considerations the aim of this trial will be to compare two different approach for sub-urethral sling positioning, transobturator and transvaginal tape (tot and tvt) performed in association to transobturator correction of anterior defect with mesh in terms of efficacy and safety.

women with anterior defect and genuine stress urinary incontinence will be enrolled and randomized in two groups (arm 1 and 2). all patients will be treated with a transobturator correction of anterior defect, in patients of arm 1 will be associated tot, whereas in patients of arm 2 will be associated tvt. all patients eligible will undergo baseline assessment consisting of anthropometric, clinical, hormonal, urodynamic, and ultrasonographic evaluations. during the study, the surgical outcomes, the clinical subjective and objective efficacy data, and the adverse experiences will be evaluated in each patient. data will be analyzed using the intention-to-treat principle and a p value of 0.05 or less will be considered significant.

Eligibility criteria:
inclusion criteria: * cystocele * genuine stress urinary incontinence by self report, examination and test * urethral hypermobility * eligible for both surgical procedures * ambulatory exclusion criteria: * pregnancy * \<12 months post-partum * systemic disease and/or drugs known to affect bladder function * current chemotherapy or radiation therapy * urethral diverticulum, augmentation cytoplasty, or artificial sphincter * recent pelvic surgery * previous pelvic or anti-incontinence surgery * history of severe abdominopelvic infections * known extensive abdominopelvic adhesions * detrusor instability and/or intrinsic sphincter dysfunction * other gynaecologic pathologies (eg, fibroids, ovarian cysts) * bmi \>30

Keywords: cystocele mesh prolapse sling stress incontinence surgery tot tvt treatment
non-invasive venous air plethysmography assessment of venous hemodynamics in patients suspected deep venous obstruction used in conjunction with intermittent pneumatic compression.

Conditions: Deep Vein Thrombosis

Summary: the purpose of this research is to measure changes in venous blood flow with an air-filled bladder under an intermittent pneumatic compression device cuff (used to prevent deep venous thrombosis) or venous diagnostic device cuff (used to detect deep venous thrombosis). the devices being used in the study are investigational and not fda-cleared.


Eligibility criteria:
inclusion criteria: * venous ultrasound study to evaluate for lower extremity dvt unilateral and/or bilateral within previous 72 hours. exclusion criteria: * patients with inaccessible target limb (ultrasound limb) due to bandages (wound, burn, lesion, etc) or cast. * patients with leg trauma, fracture, above or below knee amputation, or other condition in which compressing on the calf is medically inappropriate or not possible. * patients unable to provide informed written consent.
etiology and incidence assessment of radiographically-confirmed community acquired pneumonia (cap)

Conditions: Pneumonia

Summary: this is an epidemiological study to investigate the etiology of radiographically-confirmed community-acquired pneumonia (cap) in adults aged ≥18 years. the main objective is to determine the proportion of which cases that is due to streptococcus pneumoniae and the corresponding incidence and serotype distribution. the study will utilize a serotype-specific urinary antigen detection (uad) assay.


Eligibility criteria:
the pneumonia group inclusion criteria: * age ≥ 18 years. * present to a study healthcare facility where treating physician clinically suspects cap with the presence of two or more of the following signs and symptoms: fever, hypothermia, chills or rigors, pleuritic chest pain, cough, sputum production, dyspnea, tachypnea, malaise, abnormal auscultatory findings suggestive of pneumonia. * has radiographic finding that is consistent with pneumonia. * able and willing to provide urine sample. * signed and dated informed consent exclusion criteria: * transferred to a study healthcare facility after already being hospitalized for 48 hours or more at any other in-patient facility. * hospital acquired pneumonia. * subjects who are investigational staff members and their family members, and site staff members otherwise supervised by the investigator. * previous enrollment in this study within the previous 30 days. * other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or may interfere with the interpretation of study results and, in the judgement of the investigator, would make the subject inappropriate for entry into this study. the control group inclusion criteria: * signed and dated informed consent. * age ≥ 18 years. * able and willing to provide urine sample. exclusion criteria: * subjects who are investigational staff members or relatives of those staff member or subjects who are pfizer employees directly involved in the conduct of the study. * subjects with suspicion of cap or any other respiratory infectious disease, as well as evidence of or documented concomitant infectious disease. * subjects residing in any long-term care facilities. * subjects with known bronchial obstruction or history of post-obstructive pneumonia. chronic obstructive pulmonary disease (copd) is permissible, provided there has no been an exacerbation with 3 months prior to enrollment. * subjects with primary lung cancer or another malignancy metastatic to the lungs. * subjects with fever. * subjects with significant immunosuppressive disease such as aids, leukemia, etc. * subjects with either pneumococcal conjugate vaccine (pcv) and/or pneumococcal polysaccharide vaccine (ppv) administration within the past 30 days.

Keywords: pneumonia streptococcus pneumoniae incidence ethiology serotype
analysis of procedural times using colpassist for robotic-assisted sacrocolpopexy; a randomized controlled trial

Conditions: Pelvic Organ Prolapse

Summary: the purpose of this study is to evaluate the efficiency of the colpassist vaginal positioning device during robotic-assisted sacrocolpopexy.

the purpose of this research study is to evaluate the efficiency of the colpassist (boston scientific, natick, ma) vaginal positioning device used during robotic-assisted sacrocolpopexy. traditionally, vaginal positioning during robotic-assisted sacrocolpopexy is done using a device that was not designed specifically for sacrocolpopexy, commonly a vaginally placed endo anal sizer. it is possible the colpassist device will result in shorter operative times because colpassist is flat which makes it easier to sew against. also, the width of the device is designed to be similar to the width of the vagina which should improve visibility during surgery. enrolled patients will be randomized to undergo their planned robotic-assisted sacrocolpopexy using either a vaginally placed endo anal sizer or a vaginally placed colpassist vaginal positioning device. both surgeon and patient will be blinded to which device was used at the time of surgery. length of time to complete each step of the sacral colpoexy that involves use of a vaginal positioning device (dissection of the anterior and posterior vaginal walls, attachment of anterior and posterior vaginal mesh, attachment of sacral mesh) will be recorded during the surgery to measure operative efficiency. surgeon and surgical-assistant satisfaction will be recorded with each device.

Eligibility criteria:
inclusion criteria: * age greater than or equal to 18 years old * planned robotic-assisted sacrocolpopexy * english speaking * prior hysterectomy (either total or supra-cervical) exclusion criteria: * age less than 18 years old * non-english speaking * pregnant women, or women desiring future pregnancy * planned concomitant hysterectomy

Keywords: robotic sacrocolpopexy colpassist vaginal positioning device
vitamin d in ectopic pregnancies

Conditions: Ectopic Pregnancy; Vitamin D Deficiency

Summary: according to recent evidences, vitamin d was found to have important roles in female reproductive system, both in physiological and also pathological mechanisms. since vitamin d is tightly related with calcium metabolism, both molecules were reported to be associated with some pregnancy complications including preeclampsia, gestational diabetes, low birth weight, preterm delivery, and cesarean section rates. the aim of the present study was to evaluate the vitamin d levels in ectopic pregnancies, which may have clinical importance in the etiology of this disorder.


Eligibility criteria:
inclusion criteria: * ectopic pregnancies and * women with normal 1st trimester pregnancies exclusion criteria: * patients without any known operations or * disease history

Keywords: calcium magnesium inflammation
craniopharyngioma with tumoral hemorrhage

Conditions: Craniopharyngioma; Apoplexy

Summary: clinical data of 185 consecutive patients receiving resective operation with a pathological diagnosis of craniopharyngioma in our hospital between january 2013 and february 2021 were collected. among these patients, 18 of them were recognized as craniopharyngioma with tumoral hemorrhage during the operation.

for each case, age, gender, smoking status, alcohol intake, past history, symptoms, blood pressure, blood cell count, blood biochemical tests, coagulation tests, hormone tests, radiological results, surgical treatment and the outcome at discharge were collected. the first test result after admission and before the operation was taken for the items of blood tests with multiple times in the analysis.

Eligibility criteria:
inclusion criteria: * receive resective operation with a pathological diagnosis of craniopharyngioma in our hospital * enter our hospital between january 2013 and february 2021 exclusion criteria: * have a non-craniopharyngioma or unverified pathological diagnosis at discharge * have received surgical or radiological treatment on the sellar region * receive treatment of coagulation modulation, immunosuppressive agents or chemotherapeutic drugs * combine with other clinical emergencies including acute myocardial infarction, cerebral stroke, trauma and sepsis at admission * have been diagnosed with other tumors, hematological diseases, autoimmune diseases, liver failure or renal failure

Keywords: craniopharyngioma endocrine risk factor tumoral hemorrhage
an observational retrospective cohort study being conducted in women with atopic dermatitis (ad)

Conditions: Adverse Pregnancy Outcomes; Atopic Dermatitis

Summary: the objective of this study is to describe and compare the incidence of adverse pregnancy outcomes (spontaneous abortion/miscarriage, stillbirth) and prevalence of infant outcomes (major congenital malformations \[mcms\], small for gestational age \[sga\]) in women with ad who are treated with dupilumab during pregnancy relative to women with ad who are not treated with dupilumab during pregnancy.


Eligibility criteria:
key inclusion criteria: * continuous medical and pharmacy benefit coverage for at minimum 6 months prior to and including the estimated lmp * diagnosis code indicative of ad in the period from up to 1 year prior to the estimated lmp through the end of the pregnancy note: other protocol defined inclusion / exclusion criteria apply
national congenital heart disease audit

Conditions: Congenital Heart Disease (CHD)

Summary: the national institute of cardiovascular outcomes research (nicor) collects data and produces analysis to enable hospitals and healthcare improvement bodies to monitor and improve the quality of care and outcomes of cardiovascular patients. the congenital heart disease audit collects data on all cardiac surgery and therapeutic cardiac catheterisations procedures used to treat patients with congenital and acquired heart disease. for acquired heart disease, the audit covers all arrhythmias \& cardiomyopathies in patients less than 16 years old only. for congenital heart disease, the audit collects data on both children and adult patients. the audit covers all specialist centers in the uk and republic of ireland. the project aims to improve the quality of care for children and adults with congenital heart disease by providing national comparative analysis of procedure specific activity and outcomes of cardiac surgery and therapeutic cardiac catheterisation procedures. the audit also provides quality indicators for the antenatal detection of major congenital heart disease. the current dataset is available from here: http://www.ucl.ac.uk/nicor/audits/congenital/datasets

the congenital heart disease audit collects data on all cardiac surgery and therapeutic cardiac catheterisations procedures used to treat patients with congenital and acquired heart disease data collection: hospitals use patient administration systems and manual data entry by cardiac database managers to submit data to nicor. data are either assimilated locally using third party commercial software and imported as a .csv file, or entered directly onto the nicor database. data quality: nicor provide tools that communicate possible errors to centres submitting data. a data submitting schedule has been agreed with the centres, data is submitted and a validation report is returned each quarter. centres are responsible for updating errors in the records. an import log highlights missing and invalid data as well as records that failed to import due to data quality or compatibility issues. in addition, data is validated by on site visits with a nicor representative. data linkage: data is annually linked with office fot national statistics (ons) life status and hospital episodes statistics (hes) admission data to verify case ascertainment and to track long term outcome measures. information governance: nicor has section 251 approval and data protection registration. an organisation-wide standard operating procedure is in place for information security incident management. university college london has a robust information governance framework, to which nicor adheres.

Eligibility criteria:
inclusion criteria: patient, judged by multidisciplinary team meeting as unsuitable for the procedure exclusion criteria: patient, judged by multidisciplinary team meeting, as unsuitable for the procedure

Keywords: congenital heart disease european paediatric cardiac code short list specific procedure definitions opcs paediatric pediatric
alcohol screening in an ethnically diverse sample of adolescents in primary care

Conditions: Alcohol Use; Drug Use

Summary: screening youth in the primary care setting is one way to identify adolescents who may be at-risk for future alcohol problems. the current study tests the new niaaa screening guide questions, which ask about friend and adolescent drinking, to see how well these questions work to predict subsequent alcohol use, problems, and involvement in other risk behaviors, such as sexual risk-taking and delinquency. in addition, the investigators plan to provide a brief motivational intervention for some at-risk teens and see whether alcohol use differs for those teens who receive the intervention and those teens who receive enhanced usual care. the results of this study have the potential to significantly impact the standard of care for identifying and intervening with at- risk youth in primary care settings.


Eligibility criteria:
inclusion criteria: 1 * 12-18 * speak english exclusion criteria: * cognitive impairment

Keywords: adolescents intervention motivational interviewing alcohol and drug use
the effect of rehabilitation training on orthostatic hypotension in parkinson's patients

Conditions: Orthostatic Hypotension

Summary: the goal of this clinical trial is to explore raise-bed training orthostatic hypotension in parkinson's patients. the main question it aims to answer is: can raise-bed training improve orthostatic hypotension in parkinson's patients. patients will be randomly allocated into the control group or the experimental group, all under rehabilitation treatment, the experimental group will be given raise-bed training. the study lasts 21 days for each patient. researchers will compare orthostatic hypotension questionnaire, orthostatic grading scale, composite autonomic symptom scale 31 to see if raise-bed training can help improve the symptom

orthostatic hypotension is common in parkinson's patients. the goal of this clinical trial is to explore raise-bed training orthostatic hypotension in parkinson's patients. the main question it aims to answer is: can raise-bed training improve orthostatic hypotension in parkinson's patients. patients will be randomly allocated into the control group or the experimental group, all under rehabilitation treatment, the experimental group will be given raise-bed training. the study lasts 21 days for each patient. researchers will compare orthostatic hypotension questionnaire, orthostatic grading scale, composite autonomic symptom scale 31 to see if raise-bed training can help improve the symptom.

Eligibility criteria:
inclusion criteria: * confirmed diagnosis of parkinson's disease * presence of orthostatic hypotension, defined as a decrease in systolic blood pressure of at least 20 mmhg or a decrease in diastolic blood pressure of at least 10 mmhg within three minutes of standing up * age 40 years or older * willingness to participate in the study and provide informed consent exclusion criteria: * severe cardiovascular disease or other medical conditions that would make head-up tilt treatment unsafe or inappropriate * use of medications that affect blood pressure or heart rate, such as beta-blockers or vasodilators, and inability or unwillingness to discontinue these medications for the study period * history of syncope or falls within the past six months * inability to stand or sit up independently or tolerate changes in body position * cognitive impairment or inability to provide informed consent
effect of a probiotic, lactobacillus farciminis, in diarrhea predominant ibs patients

Conditions: Irritable Bowel Syndrome

Summary: probiotics may improve symptoms in ibs patients. the aim of this study is to test the efficacy of lactobacillus farciminis in diarrhea predominant ibs patients according to rome iii criteria.

the aim of this study is to test the efficacy of lactobacillus farciminis in diarrhea predominant ibs patients according to rome iii criteria.

Eligibility criteria:
inclusion criteria: * diarrhea predominant ibs * less than 5-year duration * pain intensity between 2 and 7 on vas exclusion criteria: * celiac disease * antibiotic treatment within the 1-month period preceding inclusion * digestive organic disease * any severe non digestive organic disease

Keywords: ibs diarrhea rome iii