Kornimate/medical-research-clean huggingface dataset:
clinical outcome following arthroscopic knee surgery

Conditions: Anterior Cruciate Ligament Injury

Summary: purpose: there are no existing data available to guide clinicians in the appropriate rehabilitation progression of patients who have undergone knee arthroscopy. the investigator intends to fill this void by establishing normative recovery curves for patients undergoing knee arthroscopy. research design: prospective observational design procedures: patients 10-70 years old will be screened for "standard of care" clinical and functional outcomes to occur at standardized time-points (post-op weeks 1-4, 8, 12, 16, 20 and return to sport/activity) following arthroscopic knee surgery. recovery curves will be plotted for all outcome variables of interest including; (1) international knee disability committee (ikdc) survey, (2) tampa kinesiophobia scale, (3) tegner activity scale, (4) marx activity scale, (5) passive knee range of motion/heel-height difference, (6) balance error scoring system (bess), (7) quad/hamstring strength ratios, (8) y-balance, (9) functional movement screening, (10) vail-sport test, (11) landing error scoring system (less), (12) hop testing, and the (13) sports metrics test. polynomial lines-of-best-fit and 95% confidence intervals will be plotted to provide objective recovery curves for clinical utilization and stratification of patient recovery. risks: there are no additional risks to "standard physical therapy practice" for post-surgical patients participating in this study. the investigator will not be using invasive procedures or testing modalities that emit radiation. benefits \& clinical relevance: this information may offer valuable information to clinicians treating patients following knee arthroscopy by providing objective data for each phase of post-operative recovery. identifying key landmarks and functional milestones may allow the ability to identify patients who are not meeting clinical expectations and subsequently tailor rehabilitation programs to improve recovery trajectories.


Eligibility criteria:
inclusion criteria: * ages 10-70; undergoing primary knee arthroscopy; \& participating in post-operative physical therapy management. exclusion criteria: * patients will be excluded from the study if they elect to not have knee arthroscopy. have other orthopedic or medical complications (fractures, deep vein thrombosis,) that would be a contraindication to standard post-operative physical therapy care.

Keywords: acl
effect of preoperative sarcopenia on postoperative delirium in elderly patients undergoing gastrointestinal surgery

Conditions: Postoperative Delirium; Sarcopenia; Gastrointestinal Surgery; Anesthesia

Summary: the goal of this observational study is to compare incidence of postoperative delirium in sarcopenic and non-sarcopenic elderly patients undergoing gastrointestinal surgery. the main question it aims to answer are: • effect of preoperative sarcopenia on postoperative delirium in elderly patients undergoing gastrointestinal surgery participants will be evaluated preoperatively for sarcopenia and assessed for postoperative delirium, pain, etc.


Eligibility criteria:
inclusion criteria: 1. age ≥ 65 years old, gender is not limited 2. patients to undergo elective abdominal surgery (gastrointestinal tumor resection) under general anesthesia, with an expected operation duration of about 2h\~4h 3. asa ⅰ-ⅲ exclusion criteria: 1. relative contraindications to general anesthesia: patients with severe heart and lung disease, severe infection, uncontrolled hypertension, diabetes, and severe diabetic complications 2. abnormal renal and liver function: ast or alt≥2.5×uln, tbil≥1.5×uln, serum creatinine concentration (scc)≥1.5×uln 3. people with a history of mental illness or long-term use of psychotropic drugs (dementia, schizophrenia), chronic analgesic drug use, alcoholism, and cognitive impairment 4. any cardiovascular or cerebrovascular accidents occurred within 3 months, such as myocardial infarction, stroke, transient ischemic attack 5. myasthenia gravis patients 6. unable to cooperate to complete the test, the patient or family member rejected the participant

Keywords: postoperative delirium sarcopenia gastrointestinal surgery anesthesia
new perspectives in the rehabilitation of children with motor disorders : the role of the mirror neuron system

Conditions: Hemiplegia; Cerebral Palsy

Summary: evidence exists that the activation of actions activates the same cortical motor areas that are involved in the performance of the observed actions. the neural substrate for this phenomena is the mirror neuron system. it is generally assumed that mirror neurons have a basic role in understanding the intentions of others and in imitation learning. there is evidence that action observation has a positive effect on rehabilitation of motor disorders after stroke. the aim of this study is to demonstrate that action observation followed by the repetition of the actions previously observed has a positive impact on rehabilitation of the upper limb in children affected by hemiplegia as a consequence of cerebral palsy. in particular, the purpose is to assess if mirror neurons could improve the amount, the quality and the velocity of movements and the cooperation between the two upper extremities.


Eligibility criteria:
inclusion criteria: * children with hemiplegia and * melbourne assessment \> 50 points exclusion criteria: * inability to collaborate * pharmacoresistant epilepsy * inability to imitate gestures * sensitivity disorders

Keywords: cerebral palsy mirror neurons hemiplegia action observation therapy children affected by hemiplegia as a consequence of cerebral palsy
the turkish adaptation, validity and reliability study of the quality of life profile for spinal deformities

Conditions: Quality of Life; Spinal Deformity; Scoliosis

Summary: the purpose of this study is to translate and culturally adapt the quality of life profile for spinal deformities (qlpsd) to turkish language and test the validity and reliability of turkish version of qlpsd in patients with adolescent idiopathic scoliosis.

the qlpsd, developed in spain, was the first questionnaire designed to evaluate hrqol in adolescents with spinal deformities. it contains 21 items in five dimensions: psychosocial functioning (7 items), sleep disturbances (4 items), back pain (3 items), body image (4 items), and back flexibility (3 items). responses to items use a 5-point likert scale. the possible score range is 21-105. the qlpsd has shown good validity and reliability. english, french and persian versions of the qlpsd have been developed and validated. good reliability and ease of use are mentioned in these versions. the qlpsd was designed to examine adolescents with spinal deformities and measure the effect of orthotic and surgical treatments on qol. this questionnaire is practical and suitable for patients with spinal deformities. as a result we choose to translate the qlpsd into turkish as it is less costly, practical and time consuming than developing a new tool. qlpsd may be preferred during follow-up of the results of conservative and / or surgical treatments for spinal deformities.

Eligibility criteria:
inclusion criteria: * aged between 10-16 years old * cobb angle 10-40 degrees * being treated with conservative treatment for spinal deformities * being accepted to answer the questionnaire exclusion criteria: * being not accepted to answer the questionnaire * having any mental disorder to prevent participation the study

Keywords: quality of life scoliosis spine validation adaptation
negative work exercise for the treatment of knee arthritis

Conditions: Osteoarthritis; Arthritis

Summary: the purpose of this study is to develop a negative work exercise regimen as an intervention for posttraumatic osteoarthritis (ptoa). "negative work" is the force produced by muscles as they lengthen, and regularly occurs with common activities such as lowering an object from a shelf or walking down stairs. in this study, the investigators are examining the effectiveness of negative work exercise over a 12-week period in older, male, veterans.

purpose: to develop a negative work exercise regimen as an intervention for posttraumatic osteoarthritis (ptoa). given that the medical management of chronic ptoa is similar to idiopathic oa, the investigators propose a randomized, clinical trial to pilot negative work exercise in veterans with knee oa as a proof-of-concept study for a subsequent investigation for people with ptoa. research setting: dc vamc, physical medicine \& rehabilitation laboratory participants: men between the ages of 50 and 70 years with a history of bilateral knee osteoarthritis will be consecutively recruited from the dc vamc rheumatology service, geriatrics service, and primary care medical service. implications/significance: the use of negative work exercise to enhance the force attenuation properties of muscle is an innovative approach to the treatment of oa and ptoa, and represents a significant departure from previous rehabilitation studies concerning arthritis. use of a negative work paradigm may prove to be beneficial for older veterans with oa and active military personnel with ptoa since similar muscle mechanics are involved in the energy absorption at the knee joint during gait. despite the functional importance of lengthening muscle actions in protecting weight-bearing joints affected by arthritis, the authors are not aware of a study that involves the sole use of a negative work intervention for oa or ptoa. addressing the aims of this proposal would lay the ground work needed to justify larger clinical trials featuring the negative work paradigm for soldiers with ptoa.

Eligibility criteria:
inclusion criteria: * adult men 50 y.o. 70 years old will be recruited for this proposed study. * participant inclusion criteria includes having bilateral knee oa (kellgren-lawrence grade 2 or 3) and sedentary (e.g., have not engaged in 3 exercise sessions per week for 3 consecutive months). * gait aides and orthoses will not preclude participation in this study. exclusion criteria: * exclusion criteria include uncontrolled cardiovascular disease, non-ambulatory status, neurogenic weakness, knee extensor and flexor manual muscle test \< 3 out of 5, lower extremity amputation, and current participation in a supervised exercise program. * in addition, major surgical procedures within the last six months, unstable joints, endocrine or metabolic disorders that result in excessive fatigue or muscle weakness, or use of medications that may impair exercise tolerance would also preclude participation in this study.

Keywords: knee arthritis veterans strength exercise muscle
safety and efficacy of varying methods of alv003 administration for the treatment of celiac disease

Conditions: Celiac Disease

Summary: a phase 2a study to evaluate the safety and efficacy of alv003 to treat celiac disease.


Eligibility criteria:
inclusion criteria: * history of biopsy-proven celiac disease * adherence to a gluten-free diet * tg2 antibody negative * signed informed consent exclusion criteria: * active dermatitis herpetiformis * history of ige-mediated reactions to gluten * use of specific medications 6 months prior to entry * history of alcohol abuse or illicit drug use * current untreated or gi disease * positive pregnancy test * received any experimental drug within 14 days of randomization * uncontrolled chronic disease or condition * uncontrolled complications of celiac disease * any medical condition which could adversely affect study participation

Keywords: celiac disease coeliac disease celiac sprue keliakia disease
ultrasound-guided percutaneous electrolysis in female soccer with soleus injury

Conditions: Injury;Sports

Summary: this study evaluates if the physiotherapy treatment based on combination of therapeutic exercise program and ultrasound-guided pne on chronic soleous injuries may cause changes in pain, dorsal flexion of the ankle and muscle fatigue in female dance


Eligibility criteria:
inclusion criteria: * older than 18 years * having a soleus muscle injury * chronic injury (\> 3 meses) * pain at stretch \> 3 points measured by nrs exclusion criteria: * belenophobia * other accuse injury * lumbar back pathology
impact of covid-19 on mental health of health care workers

Conditions: Mental Health; Quality of Life

Summary: the impact of the current covid-19 pandemic on healthcare workers is enormous. this longitudinal study investigates the prevalence of mental health problems and the quality of life of healthcare workers during and after the covid-19 pandemic. underlying risk factors are also examined. health care workers of the different covid-19 cohort and transit wards, as well as the intensive care unit and (psychiatric) emergency services of the ghent university hospital will be included, as well as the health care workers of 6 non-covid-19 wards.

the impact of the current covid-19 pandemic on healthcare workers is enormous. previous studies during the sars outbreak demonstrated a significant burden and increase of mental health problems in health care workers.this longitudinal study aims to investigate the prevalence of mental health problems and the quality of life of health care workers during and after the covid-19 pandemic. health care workers of the different covid-19 cohort and transit wards, as well as the intensive care unit and (psychiatric) emergency services of the ghent university hospital will be included, as well as the health care workers of 6 non-covid-19 wards. participants will receive a monthly online survey during the government issued restrictions. after cessation of the restrictions participants will receive three-monthly surveys for a one-year-period. sociodemographic data, data regarding employment and previous mental health problems will be collected at the first survey. the covid-19 status of the health care workers will be inquired at every survey. the depression, anxiety and stress scale (dass-21), the dutch translation of the covid-19 peritraumatic distress index (cpdi), the who quality of life-bref (whoqol-bref), and the primary care ptsd screen for dsm-5 (pc-ptsd-5) and three items measuring social support will be administered at every survey.

Eligibility criteria:
inclusion criteria: * health care worker * employed at inclusion at covid cohort/transit or (psychiatric) emergency services or intensive care unit or 6 specified wards of the ghent university hospital exclusion criteria: * none

Keywords: health care workers covid-19 mental health
the bucharest early intervention project

Conditions: Cognitive Ability, General; Psychiatric and/or Mood Disorders; Brain Function; Social Cognition; Health Behavior; Risk-Taking; Executive Function

Summary: the purpose of this study is to determine the long term effects of early intervention (placement into foster care) on physical, cognitive, social and brain development and psychiatric symptomatology in previously institutionalized children.

the bucharest early intervention project (beip) was a randomized controlled trial of foster care as an intervention for children abandoned at or around the time of birth and placed in one of six institutions for young children in bucharest, romania (zeanah et al., 2003). the pi (nelson) and co-pis (zeanah and fox) conducted this study beginning in the fall of 2000 from baseline assessments and implementation of the intervention in the spring of 2001. the beip began with comprehensive assessments of 136 institutionalized children and their caregiving environments prior to randomization. half the children were randomly assigned to high-quality foster care and the other half to remain in institutional care. the average age at foster care placement was 22 months (range=6-31 months). all children were initially seen prior to randomization and again for follow-up assessments at 30 months, 42 months 54 months, 8 years, 12 year and 16 years of age. the development of children in foster care was compared to the development of children in institutions and to a group of never institutionalized children (community controls). these children, now young adults are being assessed at age 21 years.

Eligibility criteria:
inclusion criteria for assessment at age 21 years: * previously institutionalized and community children that took part in previous beip assessments * target recruitment age is +/- 6 mos of 21st birthday exclusion criteria for assessment at age 21 years: * open or closed head injury within the past 12 months * viral or bacterial meningitis within the past 12 months

Keywords: romania, children, foster care, institutionalization, brain function, mri, attachment, language, growth, intelligence quotient (iq), psychiatric symptomatology early intervention
transdermal delivery of glucosamine to the synovial fluid of male and female with knee osteoarthritis

Conditions: Osteoarthritis, Knee

Summary: glucosamine is commonly used as a treatment for osteoarthritis (oa). while oral administration remains the most commonly used route, topical administration could offer numerous advantages such as targeted delivery to affected joints and overcoming the negative effects of the passage of the drug through the digestive system. the objective of this study is to assess the bioavailability of glucosamine in the synovial fluid of osteoarthritic joints, following the topical application of a commercially available transdermal glucosamine cream. joint fluid samples will be collected from 2 groups of participants with knee oa: the control group will not be subjected to any treatment while the test group will apply 2g of transdermal glucosamine cream 1 to 3 hours before the joint fluid collection. glucosamine concentration will be determined and the results obtained from both groups will be compared. this trial will potentially provide data to support that glucosamine can cross the skin and be delivered to the affected joint fluid when formulated in a transdermal cream base.


Eligibility criteria:
inclusion criteria: * male and non-pregnant female human subjects * 21 to 80 years old * subjects who need to undergo arthrocentesis (prescribed during prior medical assessment) * willingness to follow the protocol requirements exclusion criteria: * known allergy to shellfish * known history of hypersensitivity to glucosamine or related drugs. * known history of hypersensitivity to capsaicin (capsicum extract) * known history of skin sensitivity * subjects who have taken any kind of glucosamine during the last 24 hours * subjects who have taken any kind of treatment for joint pain during the last 24 hours * subjects having scars/cut/dermatological abnormality at application site * pregnant or nursing women

Keywords: transdermal delivery glucosamine synovial fluid osteoarthritis knee human arthrocentesis
cerebral and spinal protection of xenon post-conditioning in patients undergoing aortic dissection repair

Conditions: Aortic Dissection

Summary: with more and more people developing hypertension and atherosclerosis, the morbidity rate of acute aortic dissection（aad） has been increasing. emergency surgery is the main treatment for acute aortic dissection. however the secondary injury caused by reperfusion of spinal cord could lead to catastrophic complications,such as paraplegia, hemiplegia or even death. so spinal protection is always the hot topic in clinical research. xenon is an ideal anesthetic gases with the following features,fast onset of action, stable hemodynamics, clean and non-toxic.the animal researches have showed the protective effects of xenon to alleviate the ischemia-reperfusion injury of the nervous system.those clues suggest that xenon may have the potential protection of spinal cord in patients undergoing aortic dissection repair.in order to clarify this hypothesis, the investigators designed this randomized, controlled clinic trial to evaluate the protection of xenon against spinal cord ischemia-reperfusion injury and the potential mechanisms


Eligibility criteria:
inclusion criteria: * patients doing selective operation of bentall and sun's or partial aortic arch replacement * patients doing selective operation of the full chest and abdominal aorta replacement exclusion criteria: * emergency patient * patients with severe mental and neurological dysfunction * patients with severe hearing and visual impairment * illiteracy or patients can't cooperate with doing the cognitive function score * patients with severe cardiac insufficiency * critically ill or dying patients * patients refuse to sign the informed consent

Keywords: aortic dissection cerebral and spinal protection post-conditioning
quality of life assessment of children with congenital heart disease aged 5 to 7 years

Conditions: Congenital Heart Disease

Summary: congenital heart diseases (chd) are the firt cause of congenital malformations (8 for 1000 births). since the 90's, great advances in prenatal diagnosis, pediatric cardiac surgery, intensive care, and cardiac catheterization have reduced morbidity and early mortality in this population. prevalence of " guch ", grown-ups with congenital heart disease has thus been significantly increasing. nowadays, quality of life (qol) assessment of this population is in the foreground. our team is a reference center in the management of patient with chd, from the fetal period to adulthood. the investigators have been conducting a clinical research program on health related qol in pediatric and congenital heart disease. the investigators thus demonstrated the link between cardiopulmonary fitness and qol in children with chd aged 8 to 18 years, the correlation between functional class and qol in adults with chd, and the impact of therapeutic education on qol in children under anticoagulants. currently, no controlled cross-sectional quality of life study assessment has been leaded in the youngest children with chd. this present study therefore extends our work in younger children aged 5 to 7 years.

248 patients will be enrolled in this study. patient from groups 1 is included during his annual medical check-up. quality of life questionnaire and other examinations are performed during this site visit. its is a part of his usual care. no supplementary visit, directly related to the research, are necessary. 2 sites will participate to the enrollment, belonging to the french national network for complex congenital heart diseases (m3c) . participants (healthy children) from groups 2 are included from schools.the prior agreement of the ministry of national education was obtained before any procedure related to this study. 3 schools will participate to the enrolment

Eligibility criteria:
inclusion criteria: • children with chd (as defined in the acc-chd classification) aged 5 to 7 years or same aged school children. exclusion criteria: * other comorbidity affecting quality of life (polymalformative syndrome, extracardiac organ failure, neurodegenerative disease, severe genetic disease, psychomotor retardation). * surgical procedure during the last 6 months. * inability to understand the qol questionnaire (parents and / or child): non-french speaker, severe intellectual disability.

Keywords: health related quality of life congenital heart disease pediatrics cardiology pedsql 4.0 psychometric properties