Kornimate/medical-research-clean huggingface dataset:
gene expression profiling and bioinformatic analysis identifying genes and biochemical pathways in type 2 diabetes

Conditions: Type 2 Diabetes

Summary: type 2 diabetes is a disorder of the metabolic system that greatly affects individual health and imposes significant cost for society on health care. it is necessary to initiate research with emphasis on improvement on quality of life and reduce the serious complications as a result of type 2 diabetes. in type 2 diabetes insulin resistance and impairment of insulin secretion by beta-cells are the major pathophysiological defects and characterized by raised plasma glucose levels. today, little is known about gene regulation and biochemical pathways involved in the disease. bioinformatics and gene expression microarrays (gem) will be applied to gain insight into the molecular pathophysiology of type 2 diabetes. the simultaneous monitoring of thousands of genes in parallel can identify novel genes and entire biochemical pathways that are dysregulated at the transcriptional level. affymetrix inc. chips or spotted arrays will be applied as dna microarray tools. bioinformatic software programs and databases will be employed as data mining tools in order to perform statistical analysis, cluster analysis and biochemical pathway analysis. biopsies from skeletal muscle and adipose tissue from both diabetics and nondiabetics will be applied. changes in genes and biochemical pathways between diabetics and nondiabetics and functional relationships between adipose tissue and skeletal muscle will be investigated. grouping of subtypes in type 2 diabetes will be performed and a classification system will be constructed. building a classifier may provide better and more precise diagnosis of type 2 diabetes. major advances in health science of type 2 diabetes thus seems to be promising and paving the way for individual treatment based on a more precise diagnosis.


Eligibility criteria:
inclusion criteria: of diabetic subjects: * type 2 diabetes * age: 30-65 years * bmi: 27-35 of nondiabetic subjects: * age: 30-65 years * bmi: 27-35 exclusion criteria: of diabetic subjects: * medication, which have any influence on glucose metabolism and gene expression in adipose tissue and skeletal muscle at the time of sampling of biopsies. * disease in liver, heart, vessels or endocrine organs of nondiabetic subjects: * type 2 diabetes * relatives with type 2 diabetes * hyperglycemia * medication, which have any influence on glucose metabolism and gene expression in adipose tissue and skeletal muscle at the time of sampling of biopsies. * disease in liver, heart, vessels or endocrine organs

Keywords: type 2 diabetes microarray skeletal muscle bioinformatics
a question prompt sheet for depressive outpatients

Conditions: Depression

Summary: question prompt sheet for outpatients suffering from depression. effects on patient-doctor-communication during the consultation.


Eligibility criteria:
inclusion criteria: * 18-65 years * male and female patients * outpatients * informed consent exclusion criteria: * poor german language skills
comparison between ultra sound guided rectus sheath block and field block for midline hernia repair

Conditions: Ultrasound Guided Rectus Sheath Block; Pain, Postoperative

Summary: randomized double blinded controlled clinical trial will be done with a total number of 75 patients will be divided into 3 groups. to compare between ultra-sound guided rectus sheath block vs field block infiltration in providing a good analgesia for patients undergoing midline hernia repair to detect which one is superior.

75 patients undergoing midline hernia repair under general anesthesia will be recruited and will be randomly allocated using closed envelope technique as follows: control group, local infilteration (field block infilteration) group, ultra sound guided rectus sheath block group. general anesthesia will be standardized for all patients with : 2 µg kg-1 fentanyl and 2 mg kg-1 propofol. neuromuscular blockade will be achieved with 0.5 mg kg-1 atracurium followed by tracheal intubation. muscle relaxation will be maintained by 0.1mg / kg / 30 minute of atracrurium. anesthesia will be maintained by sevoflurane. mechanical ventilation will be adjusted with fresh gas flow oxygen in air 30-50% at a rate of 1 l min-1to maintain end-tidal carbon dioxide of 35-40 mm hg and spo2 greater than 94%. bis values will be maintained between 40 and 60. all surgical procedures will be done in the range between 10 am and 1 pm and by the same surgical team. 1. control group : will receive field block using 0.3 ml/kg of normal saline at site of the hernia plus ultra- sound guided rectus sheath injection using 0.3 ml / kg of normal saline. 2. field block group: will receive 0.3 ml / kg of 0.5% bupivicaine subcutaneously surrounding the site of the hernia following the induction of anesthesia and ultra-sound guided rectus sheath block with 0.3 ml / kg of normal saline. 3. ultrasound guided rectus sheath block : under sterile conditions a 21/22 g , 50- 100 milli meter length echogenic needle guided by the ultrasound into rectus sheath at the level of the umbilicus , using an - in plane technique. after -ve aspiration 0.3 ml/ kg of 0.5 % bupivicaine will be deposited on each side and the spread of local anesthesia will be observed by ultrasound plus 0.3 ml/kg of normal saline subcutaneously at the site of the hernia. all solutions used will be prepared by a colleague who will not participate into the study.

Eligibility criteria:
inclusion criteria: 1. elective midline hernia repair surgery. 2. age: adult patients between 18 - 60 years old. 3. gender: both male and female. 4. asa class: i \& ii. exclusion criteria: 1. refusal of patient. 2. pregnancy and lactation. 3. fever or sepsis. 4. patients asa iii or iv. 5. addicts and drug abusers. 6. patients taking corticosteroids or any cardio - active drugs. 7. local infection at site of the injection. 8. allergy to any of the study medications.
the effect of (asmr) videos on sleep quality and stress levels on nursing students

Conditions: Students; Nursing

Summary: this study was planned to evaluate the effect of autonomous sensory meridian response (asmr) videos on sleep quality and stress levels of nursing students before clinical practice.

autonomous sensory meridian response (asmr) is a physiological phenomenon that describes a tingling sensation caused by specific visual and auditory triggers, usually starting on the scalp and travelling down the body. these trigger stimuli are often socially intimate in nature and often involve repetition of movements and/or sounds. according to studies conducted among university students, it is generally stated that university students have poor sleep quality and sleep inadequately. negative impact on students' sleep quality is a factor that causes them to experience stress. nursing students are faced with an important source of stress due to the various situations they encounter in the education and practice processes. although clinical education offers rich opportunities to gain hands-on experience, it is reported that the clinical component of nursing education provides the highest source of stress for nursing students. this study was planned to evaluate the effect of autonomous sensory meridian response (asmr) videos on sleep quality and stress levels of nursing students before clinical practice.

Eligibility criteria:
inclusion criteria: * over 18 years, * illiterate, * volunteer to participate in the study * first-year nursing students who have not done clinical practice before exclusion criteria: * have done clinical practice before

Keywords: autonomous sensory meridian response anxiety sleep
a study of korean society of spine surgery on the outcomes of anterior cervical discectomy and fusion

Conditions: Radiculopathy, Cervical; Myelopathy

Summary: the purpose of this study is firstly to determine the efficacy of cervical plate for anterior cervical discectomy and fusion using cervical cage, and secondly to investigate the determining factors for surgical outcomes.


Eligibility criteria:
inclusion criteria: * degenerative cervical disease * radiculopathy or myelopathy refractory to conservative treatment * be scheduled to undergo one segment anterior cervical discectomy and fusion * age is more than 19 years old * all requirements of preoperative image studies are satisfied exclusion criteria: * previous neck surgery or radiation treatments at neck area * fusion at adjacent segments * two segment fusion is expected * c2-3 or c7-t1 * high risk for additional cervical surgery within one year * ossification of posterior longitudinal ligaments, trauma, infection, tumor, congenital or developmental disease * inadequate radiological images * patient is not expected to be observed at long term follow-up (foreigner, international student)

Keywords: degenerative cervical disease anterior cervical discectomy and fusion plate and cage cage alone
group-based acceptance and commitment therapy for family caregivers of people with dementia in japan

Conditions: Dementia; Family Caregivers

Summary: along with more people worldwide having dementia, the number of people with dementia and their family caregivers have increased in japan. however, psychological support for family caregivers of people with dementia is still limited in japan. the purpose of this pilot study is to examine feasibility and preliminary efficacy of a group-based acceptance and commitment therapy (act) for family caregivers of people with dementia in japan compared to a group-based cognitive behavior therapy (cbt). this study also preliminarily examines the efficacy of combining psychological intervention for family caregivers (group-based act/cbt) with psychological intervention for their care recipients (group-based reminiscence therapy).

this study employs quasi-experimental design to investigate the feasibility and preliminary efficacy of the group-based act for family caregivers of people with dementia compared to the group-based cbt. both interventions consist of eight sessions, each lasting about 90 minutes, through face-to-face or zoom video conferencing over the course of four months. family caregivers will be assigned to either the act or cbt interventions. pre-, post-intervention, and 6 month follow-up measurements assess depression, anxiety, quality of life, cognitive appraisal of caregiving (i.e., subjective burden and positive aspect of caregiving), possible process factors (i.e., caregiving self-efficacy, experiential avoidance, and commitment), care recipients' behavioral and psychological symptoms of dementia (bpsd), and so on. this study also preliminarily examines the efficacy of combining psychological intervention for family caregivers (i.e., the group-based act/cbt) with those for their care recipients (i.e., group-based reminiscence therapy). the group-based reminiscence therapy will be held once or twice a month, each lasting about 60-90 minutes, over the course of about three months.

Eligibility criteria:
inclusion criteria: family caregivers: * providing care for a family member with dementia or mild cognitive impairment * being able to speak and read japanese * being 20 years of age or older. care recipients (group-based reminiscence therapy): * having a clear intention to participate in the intervention * being able to speak japanese * being diagnosed with mild cognitive impairment or mild stage of dementia and moca scores ≥ 11 * obtaining consent from their family caregiver and their doctor to participate in the intervention. exclusion criteria: family caregivers: * having psychiatric disorder at the time of participation in the intervention. care recipients (group-based reminiscence therapy): * having insufficient capacity to give consent to participate in the intervention * being diagnosed with moderate to severe stage of dementia or moca scores \< 11.

Keywords: dementia family caregivers acceptance and commitment therapy cognitive behavior therapy reminiscence therapy
valsartan optimal therapy against elevated home blood pressure research（voyager）study

Conditions: Hypertension

Summary: the purpose of this study is to compare improvement percentage of urinary albumin excretion between valsartan 80 mg- and valsartan 160 mg-based therapy in patient with morning hypertension.

the cardiovascular diseases such as stroke and myocardial infarction consist 50% of the cause of death in japanese population. numerous mega trials have shown that strict anti-hypertensive therapy could reduce cardiovascular morbidity and mortality in hypertensive patients. it is reported, however, over 50% hypertensive patients have not been controlled below therapeutic target blood pressure that the jsh2004 guideline recommends. recently use of angiotensin ii receptor blockers (arbs) is increasing progressively for their pharmacological action on organ protection as well as potent reduction in blood pressure. however, usual dosage of arb in japan is almost half of that in the mega trials executed in europe and america. lower dosage compared to western countries might be a reason why cardiovascular events are not fully reduced in japan. valsartan optimal therapy against elevated home blood pressure research (voyager) study will be a multi-center, open-label, randomized, active-controlled study to evaluate the following; improvement percentage of urinary albumin exception, home blood pressure, hospital blood pressure, incidence of stroke, cardiovascular disease, and microangiopathy with valsartan 80 mg- or valsartan 160 mg based therapy in patients with elevated morning home blood pressure.

Eligibility criteria:
inclusion criteria: * outpatients aged over 20 years and less than 80 years, regardless of sex. * patients with stable seated morning home blood pressure of over 135 mmhg and/or diastolic blood pressure of over 85 mmhg within 1 to 2 weeks. * patients who are on therapy with conventional dosage of arb. exclusion criteria: * patients who are difficult to measure home blood pressure. * patients with secondary hypertension or malignant hypertension. * patients with seated systolic blood pressure of over 200 mmhg. * patients with seated diastolic blood pressure of over 120 mmhg. * patients with a history of cerebrovascular disorder or myocardial infarction or heart failure within 6 months prior to enrolment in the study. * patients with atrial fibrillation, atrial flutter, or serious arrhythmia. * patients with renal dysfunction with serum creatinine level of over 2 mg/dl. * patients with serious liver dysfunction. * patient with hba1c of over 8 percent. * patient with positive albuminuria by dip and read stick test. * patient treated with any angiotensin converting enzyme inhibitor * pregnant women * patients with a history of hypersensitivity to valsartan. * other patients who are judged to be inappropriate for the study by the investigator or sub-investigator.

Keywords: home blood pressure
biomechanical gait analysis in patients post-stroke

Conditions: CVA (Cerebrovascular Accident); Stroke

Summary: randomized trial of patients with cerebrovascular accident (cva) receiving traditional and body weight supported (bws) gait training. participants are enrolled and randomized upon entry into acute care and gait is evaluated within 48 hours of discharge from the rehabilitation hospital. gait analysis is used to determine which of the two groups achieved gait parameters most similar to the normal gait of an age-matched population.

potential participants are identified upon admission to acute care post cerebrovascular accident (cva) and screened for inclusion. informed consent is obtained from the patient and/or designee. demographic information is obtained from the medical record, the patient and/or designee by the clinical coordinator. the participant is randomized into traditional gait training group or body weight support (bws) group. the participant receives the required amount of physical therapy as directed by clinicians at the acute care facility and accrediting agencies. the traditional gait training group will receive gait training as presently performed without additional modalities. the bws group will received bws gait training in lieu of traditional gait training. participants will be treated in in-patient rehabilitation for a duration as determined by the clinical team; thus, the overall duration of care may be variable between participants. time spent in gait training activities for both groups will be tracked by both service unit and by time (minutes). within 48 hours of discharge from the acute care facility, the participant will be transported to a separate site for kinematic gait analysis using a marker based motion capture system. the procedure for gait analysis is as follows: 1. investigators will place reflective markers on the following areas using non-latex adhesive tape: top of the shoulders, bony part of the pelvis on the front and back, hips, front of the thighs, outside of the knees, front of the shins, outside of the ankles, first and fifth toes, and back of each heel. 2. the participant will walk across the room in the gait analysis lab no more than 20 times at his/her choice of pace while the camera system records gait parameters and kinematics. he/she will be allowed to rest as needed during the data collection. 3. the reflective markers and adhesive tape will be removed and the participant thanked for his/her participation.

Eligibility criteria:
inclusion criteria: * current in-patient in acute care for cerebrovascular accident (cva), * unilateral cva affecting at least the lower limb, and * medically stable as determined by the rehabilitation physician. exclusion criteria: * previous (more than 1) cva with residual lower limb deficit, and * any lower extremity pathology on the affected side other than the effects of the cva.

Keywords: body weight support
intervention for smoking cessation in pre-surgical patients.

Conditions: Smoking; Smoking Cessation; Surgical Procedure, Unspecified

Summary: the goal of this clinical trial is to assess efficacy of an intensive pre-surgical intervention to quit smoking in smoking patients who will be operated on implant orthopedic surgery or general and urological surgery. the main question\[s\] it aims to answer are: * evaluate the efficacy of intensive pre surgical intervention to quit smoking compared to a brief intervention * evaluate the implementation of this protocol. participants will be randomized to 2 intervention groups (patients programmed for protesic implant orthopedic surgery in the first group, and general and urological surgery) and 2 control groups (stratified in the same manner as the intervention groups), and will be monitored through telematic check ups via phone calls.

1. subject recruitment in pre surgical anesthesiology consults, data collection and randomization within 48 hours of said visit. 2. subjects in the intensive intervention group will be sent to a specialized preventive medicine consult for smoking cessation, completing 6 visits (2 before surgical intervention, 4 visits withint the following 12 months). subjects in the control group will receive brief advice on quitting smoking through a phone call the the same day randomization is performed. both groups will receive follow up calls at months 1, 3, 6, and 12, after surgical intervetion. all patients will have their smoking habits evaluated and the relevant data about the surgical intervention collected the day of the intervention. 3. at month 7 adecuacy of the protocol will be evaluated to assess if any modifications are necessary. 4. data entry and quality control of the database will be performed periodically for the duration of the study.

Eligibility criteria:
inclusion criteria: * patients must 18 years old or older, and be able to consent. * surgery programmed for at least 4 weeks after inclusion in the study. * smokers exclusion criteria: * pregnancy * already under treatment for smoking cessation * inability to consent due to cognitive impairment or language barrier. * non-primary knee or hip replacement surgery * participation in any study that forbids use of nicotine substitution therapy (dermal, oral)

Keywords: smoking smoking cessation tobacco use disorder surgery
minimally invasive non surgical therapy versus conventional scaling and root planing for treatment of periodontitis

Conditions: Periodontal Diseases

Summary: minimally invasive non-surgical therapy (minst) is a new approach towards regeneration of deep periodontal defects. important part of minst procedure, besides usage of magnification loupes and piezo-electric devices seems to be the usage of special mini-curettes, originally mini-five and after mini-five of hu-friedy. so far only descriptive data about the clinical effects of such procedure are available and comparative studies that would include other treatment alternatives are lacking. therefore, the aim of our study is, on split-mouth model, to compare the number of diseased sites (defined by probing depth ˃ 4 mm and bleeding on probing) after conventional non-surgical therapy and minst with the usage of special mini-curettes. in addition, new 3d parameters obtained from 3d optical scanning will be developed for evaluation of volume changes of soft tissues.


Eligibility criteria:
inclusion criteria: * periodontitis stage iii, grade b/c * at least 20 teeth * at least 9 teeth (excluding molars) in the upper jaw * without fpd, implants * without occlusal trauma signs * no pathology of endodontic origin * without chronic systemic diseases * no periodontal treatment in the last 6 months exclusion criteria: * poor oral hygiene (pi \> 20% at evaluation) * antibiotic treatment in the last 6 months or during the observation period * pregnant women, lactation, serious chronic systemic diseases, medication with known influence on periodontium or wound healing

Keywords: periodontitis minst scaling and root planing split mouth 3d analysis
hypo-fractionated stereotactic body radiotherapy for localized prostate cancer

Conditions: Prostate Cancer

Summary: this is an observational study in which a questionnaire is used to obtain quality of life data after patients undergo a hypo-fractionated course of stereotactic body radiotherapy (sbrt) for the treatment of their prostate cancer. the sbrt itself is considered standard of care for these patients and as such, is not an official component of the study.


Eligibility criteria:
inclusion criteria: * eligible patients will have clinical stage t1c, t2a, or t2b, a pre-biopsy psa level \<10 ng/ml and a biopsy gleason score of 3+3 (or 3+4 if fewer than 30% of biopsy cores are involved). * the ability to understand and willingness to sign a written informed consent are necessary. exclusion criteria: * patients with tumor parameters that fall outside of the inclusion criteria. * patients with evidence on imagining (bone scan, ct, or mri) suggestive of disseminated disease. * patients who have had any form of prior prostate treatment (surgery, radiotherapy, cryotherapy, high intensity focused ultrasound, turp). * a prior course of hormone therapy (androgen deprivation) of greater than 3 months duration. * the use of other concurrent investigational agents. * there are no exclusions due to co-morbid disease or illnesses except for patients with severe inflammatory bowel disease. * no life expectancy restrictions will apply. * performance status will not be considered.

Keywords: t1c t2a t2b