Kornimate/medical-research-clean huggingface dataset:
cyanoacrylate with or without suture?

Conditions: Wound Heal

Summary: an epithelialized gingival graft will be harvested from the palate for the treatment of various mucogingival deformities. the donor site will be treated with either a combination of a collagen sponge and cyanoacrylate or a collagen sponge, cyanoacrylate, and suspending sutures. intraoperatively, measurements will be taken for palatal tissue thickness, graft dimensions, working time, and primary bleeding time. data regarding pain perception will be gauged using a visual analog scale, and the number of analgesics, secondary bleeding, epithelization level, and color match will be assessed prospectively. these outcomes will be evaluated on the first 7 days and subsequently on the 14th, 21st, and 28th days. patient-reported outcomes will be recorded using the oral health impact profile-14 questionnaire.


Eligibility criteria:
inclusion criteria: inclusion criteria: * age ≥18; * mucogingival surgical treatment indication that needs connective tissue graft in the anterior mandible; * stable periodontium after phase i therapy; * full-mouth plaque and bleeding scores \<15% exclusion criteria: * previous palatal harvesting history; * unstable endodontic conditions; * tooth mobility at the surgical site; * systemic disease; * pregnancy; * use of medications with potential adverse effects on periodontal tissues
randomized pilot study of a mhealth app for ambivalent smokers living with hiv

Conditions: Smoking; Smoking Cessation

Summary: this pilot study will assess the acceptability and feasibility a novel mhealth app designed for smokers who are ambivalent about quitting and have been diagnosed with hiv.

this study will use a randomized, parallel, two-arm trial to compare outcomes between people assigned to use a "standard care" mhealth app versus a similar app with additional content targeted to people living with hiv. a total of up to 50 people will be enrolled and followed for three months to assess outcomes.

Eligibility criteria:
inclusion criteria include: * 18 years of age or older; * comfortable speaking and reading in english; * smoked at least 100 cigarettes in their lifetime; * smoked, even a puff, in the past 7 days; * smoked at least 5 cigarettes a day; * are interested in quitting smoking someday, but not in the next month; * have an iphone operating system (ios) or android smart phone which they use at least weekly; * are willing to upgrade their phone operating system, if needed; * agree to download and try the app; * do not use virtual private network (vpn) on their smart phone; * live in the united states and have a valid u.s.-based mailing address and phone number; * have been diagnosed with hiv exclusion criteria include: * refusing to answer all screening questions * history of dementia or psychosis * visual impairments that preclude their ability to view content on their smart phone and lack adaptive devices to view content * contraindications for nicotine replacement therapy (nrt) use (e.g., based on medical history or daily smoking level)

Keywords: hiv
the diagnostic value of contrast-enhanced ultrasound in acute kidney injury in icu

Conditions: Intensive Care Unit; Acute Kidney Injury; Ultrasound

Summary: the goal of this observational study is to quantitatively assess the renal microcirculation changes by contrast-enhanced ultrasound (ceus) and to obtain systemic hemodynamic information by ultrasound doppler at the same time, to analyze the relationship between renal microcirculation changes and systemic hemodynamic changes, and to explore the diagnostic value of ceus in critically ill acute kidney injury.

the main questions it aims to answer are: 1. to explore the quantitative parameters of contrast-enhanced ultrasound which can reflect the changes of renal microcirculation。 2. to explore the relationship between renal microcirculation and systemic hemodynamics。 3. to explore the value of quantitative evaluation of renal microcirculation changes by contrast-enhanced ultrasound in the diagnosis of acute kidney injury

Eligibility criteria:
inclusion criteria: * age\>18 years old * first admission to icu \< 24h after admission and expected icu stay ≥48 hours * acute kidney injury risk factors (kdigo 2012) * contrast-enhanced ultrasound exclusion criteria: * known severe chronic kidney disease (ckd≥ stage 4) or undergoing hemodialysis treatment * kidney transplantation or renal malignancy * terminal stage of malignant tumor * pregnancy * renal artery stenosis or renal vein thrombosis * the quality of ceus images is poor, and quantitative analysis cannot be performed
the influence of the ear popper on serous otitis media and on the accompanying conductive hearing loss in children

Conditions: Otitis Media; Conductive Hearing Loss

Summary: this study is designed to check the effect of the use of the ear popper device on serous otitis media in children and on the conductive hearing loss accompanying the otitis. it is intended that 30 children aged 3-18 years will participate in the study. the inclusion criteria are : clinical serous otitis media for a duration of more then 3 months, a conductive hearing loss of at least 15 decibels air bone gap and tympanometry type b or c. the children will use the ear popper for 7 weeks. they will undergo otologic examination, audiometry and tympanometry at the beginning ao the trial, at 7 weeks and at 3 months from the beginning of the trial. the otologic findings and the audiometry and tympanometry results before and after the trial will be compared. we will try to determine whether the use of the ear popper in the test group will improve the conductive hearing loss and prevent the need for tympanostomy tube insertion.


Eligibility criteria:
inclusion criteria: * serous otitis media for more then 3 months * conductive hearing loss of more then 15 decibels. * tympanometry type b or c. exclusion criteria: * no history of tympanostomy tube insertion or adenoidectomy * no cranio or facial malformations * no acute upper respiratory tract infection or acute otitis media

Keywords: effusion otitis media ear popper children
next steps: a community-led solution to address childhood obesity

Conditions: Obesity

Summary: the purpose of next steps pilot intervention is to develop and test a new program designed to help low-income multiethnic families with overweight or obese children achieve long-term maintenance of healthful behaviors following completion of hennepin county medical center's (hcmc) 16-week intensive obesity management course (taking steps together (tst)).

next steps is a community based pilot intervention study conducted in collaboration between community leaders, the university of minnesota, hennepin county medical center (hcmc) and the family partnership. the study collaborators will develop and test a new program designed to help low-income multiethnic families with overweight or obese children achieve long-term maintenance of healthful behaviors following completion of hcmc's 16-week intensive obesity management course (taking steps together (tst)). next steps, the focus of this study, will comprise a network of parent-led, community-based health maintenance programs that will be offered to tst graduate families. project aims: aim 1: establish a core parent leadership group and health maintenance program network that is self-sustaining and can serve the community for years to come. aim 2: test the feasibility, acceptability and sustainability of the next steps programs. aim 3: assess the impact of the next steps programs on helping participant families sustain or improve healthful behaviors and achieve or maintain healthy body mass index (bmi).

Eligibility criteria:
inclusion criteria: * families that are graduates of the taking step together program. * families with at least one overweight or obese child between the ages of 7-17. * family members of all ages who have graduated from the taking steps together program will be included in the study. exclusion criteria: * families who are not graduates of the taking steps together program. * families who do not have one child that is between the ages of 7-17 and who is overweight or obese
ifr guided multi-vessel revascularization during percutaneous coronary intervention for acute myocardial infarction

Conditions: Acute Myocardial Infarction; Multi Vessel Coronary Artery Disease

Summary: in patients with acute st-elevation myocardial infarction (stemi), 40-60% have multi-vessel disease with an increased cardiovascular morbidity and mortality. although it is not recommended to revascularize noninfarct lesions during the acute intervention, recent investigations suggest the opposite and show improved outcome after direct revascularization of noninfarct lesions. it is undesirable to risk procedure-related complications by treating noninfarct lesions without impaired flow. it is currently unknown whether pressure guided revascularization of noninfarct lesions in the acute phase improves outcome compared to the current guidelines. the imodern trial aims to compare an ifr-guided intervention of noninfarct lesions during the acute intervention with a deferred stress perfusion cmr-guided strategy during the outpatient follow-up, to determine the optimal therapeutic approach for stemi patients with multivessel lesions.

study design: the study is a prospective, randomized controlled, multicentre study. study population: the research population will be recruited from the general patient population presenting with an acute stemi. patients treated with successful primary pci and one or more additional significant coronary lesions in another coronary artery will be enrolled in the study. a total of 1,146 consecutive patients will be included. intervention: the patients will be randomized 1:1, to (a) an active treatment arm with complete, ifr-guided revascularization of every noninfarct coronary lesion \>50% and ifr ≤0.89; (b) a deferred treatment arm, in which patients will undergo an adenosine stress perfusion cmr scan within 6 weeks after stemi, with revascularization of the noninfarct coronary lesions with associated perfusion defects. main study parameters/endpoints: the primary end point consists of a combined outcome, including all-cause death, recurrent mi and hospitalization for heart failure at 3 years follow-up. duration: anticipated recruitment is 2 years. follow-up will be performed at 6 months, 12 months, 3 years and 5 years.

Eligibility criteria:
inclusion criteria: * clinical presentation of stemi and successful primary pci within 12 hours from onset of symptoms. * one or more other, noninfarct coronary artery lesions of \>50% stenosis and feasible to be revascularized (i.e. minimal diameter 2mm). exclusion criteria: * history of myocardial infarction. * hemodynamic instability, respiratory failure, kilips class ≥iii. * known gfr\<30 ml/min. * known contra-indications for stress cmr (e.g.: severe claustrophobia, metal implants, severe renal failure, severe astma). * refusal or inability to provide informed consent. * life expectancy due to noncardiovascular co-morbidity of less than 12 months. * chronic total occlusion. * left main stem stenosis (\>50%). * residual noninfarct lesion in infarct coronary artery. * complex (e.g. bifurcation) noninfarct target lesions.
weight reduction with the low-insulin-method

Conditions: Overweight and Obesity

Summary: background: overweight and obesity affect health, quality of life and ability to work. therefore, the low-insulin-method was developed to support overweight and obese people in weight loss. method: in a randomized controlled clinical trial, the effect of the lifestyle intervention program 'low-insulin-method', delivered by the low-insulin-app including low-carb diet, self monitoring of weight, physical activity and telemedical coaching is examined compared to a control group without coaching. the learning contents are taught in 30 videos and 5 online meetings. the intervention group additionally gets 4 individual care calls. the state of health is examined at the beginning and after 12 weeks. objective: the aim is to develop a training and counseling program for overweight or obese individuals with diabetes risk or type 2 diabetes, which can be used both for primary and for tertiary prevention of overweight-related diseases.


Eligibility criteria:
inclusion criteria: * body mass index 25 kg/m2 exclusion criteria: * none
improving hypertension medication adherence for older adults

Conditions: Aging; Medication Adherence; Hypertension

Summary: this randomized controlled trial will assess the efficacy and scalability of a blood pressure technology system intervention. the investigators will enroll 224 older adults with hypertension to identify those who are nonadherent for one hypertension medication. the participants will be randomized to one of two groups (112 per group) to use the blood pressure system for 6-months. both groups receive information about high blood pressure and medications. one group will also receive strategies that can be used to take medications and manage blood pressure. both groups will complete a mid-assessment at 3-months and a post-assessment at 6-months.


Eligibility criteria:
inclusion criteria: * age 65 years or older * self-manage at least one hypertension medication * able to read and speak english * willing to participate in the study for six months * currently have and use an apple iphone * have hypertension medication adherence ≤ 90% in the last 2 weeks of the 4-week baseline monitoring period using an aardex mems® cap exclusion criteria: * have inadequate visual acuity (worse than 20/50 corrected near vision on snellen test) * experience severe depression (\> 11 on geriatric depression scale short form, gds-15) * are at risk for cognitive impairment (\< 23 on montreal cognitive assessment, moca) * been instructed by their healthcare provider to withhold their blood pressure medication
effects of kinesio tape on chronic low back pain

Conditions: Low Back Pain

Summary: this clinical trial aims to examine kinesiotape's (kt) short-term effect on individuals with nonspecific chronic lbp (clbp), including back-specific body perception, pain, functional disability, and physical activity. the hypothesis is that applying kt to the lumbar spine would improve back-specific body perception, reduce pain and functional disability, and increase physical activity in individuals with clbp compared to the sham-taping group.

low back pain (lbp) is prevalent and the leading cause of disability worldwide. in addition, it is often associated with psychological, social, and physical factors that can impact one's ability to function, participate in society, maintain job satisfaction, and socioeconomic status. therefore, managing it requires a significant amount of healthcare resources. maladaptive body image and maladaptive beliefs are among the conditions that can be targeted during treatment as they may contribute to the chronicity of lbp. this clinical trial aims to examine kinesiotape's (kt) short-term effect on individuals with nonspecific chronic lbp (clbp), including back-specific body perception, pain, functional disability, and physical activity. the hypothesis is that applying kt to the lumbar spine would improve back-specific body perception, reduce pain and functional disability, and increase physical activity in individuals with clbp compared to the sham-taping group.

Eligibility criteria:
inclusion criteria: * ability to speak and write turkish fluently * have been experiencing low back pain for at least 3 months * have a pain severity score of ≥4 on the visual analog scale exclusion criteria: * had significant spinal surgery in the past (fusion or discectomy), spinal surgery within the last six months, * a diagnosis of a serious spinal condition (such as cancer, inflammatory arthropathy, or vertebral fracture), * skin allergy to kt or pre-existing skin lesion or infection * a neurological disease, * is currently pregnant,

Keywords: functional disability pain kinesiotape physical activity
profit - prostate fractionated irradiation trial

Conditions: Prostate Cancer

Summary: this trial is designed to determine whether an 8-week course of escalated dose conformal radiation can be compressed safely, and with similar efficacy into a 4-week course.

in this trial, men with intermediate risk prostate cancer will be randomized to a shorter course of radiotherapy (6000cgy in 20 fractions over 4 weeks-hypofractionated) or treatment with a conventional fractionation course (7800cgy in 39 fractions over 8 weeks-standard). three-dimensional conformal radiation treatment techniques, including intensity modulated radiotherapy will be used for both hypofractionated and standard treatments to avoid normal tissue exposure to radiation and minimize the risk of acute and late treatment related toxicity. the primary outcome measure is biochemical (psa) failure defined by the astro consensus criteria. secondary outcomes include biochemical-clinical failure (bcf), mortality from cancer, toxicity and health-related quality of life. it is planned to recruit 1204 patients to the study. if the safety and efficacy of the shorter course are demonstrated, then its adoption would reduce the social, emotional and economic burden of treatment for patients and their families.

Eligibility criteria:
inclusion criteria: 1. histologic diagnosis of carcinoma of the prostate within 6 months of entry without evidence of metastatic disease to the lymph nodes, bone or lung; 2. intermediate risk prostate cancer (that is, t1-2a, gleason score \<6, psa 10.1-20.0 ng/ml; t2b-c gleason \<6, psa ≤ 20.0 ng/ml; t1-2, gleason 7, psa ≤ 20.0 ng/ml). exclusion criteria: 1. histologic diagnosis of carcinoma of the prostate more than six months prior to study entry; 2. previous therapy for carcinoma of the prostate other than biopsy or transurethral resection; 3. patients previously on more than 12 weeks of hormone therapy for treatment of their prostate cancer; 4. any other active malignancy (untreated, progressive or recurrent), except for non-melanoma skin cancer. any inactive malignancy diagnosed within 5 years of entry, except for non-melanoma skin cancer; 5. treatment plan cannot meet dose constraints for the hypofractionation arm of the trial; 6. previous pelvic radiotherapy; 7. inflammatory bowel disease.

Keywords: prostate cancer localized prostate cancer intermediate risk prostate specific antigen psa radiation fractionation shorter schedule quality of life
impact of extubation location after surgery on perioperative times

Conditions: Anesthesia; Intubation; Surgery; Extubation; Respiratory Failure; Complication,Postoperative

Summary: the additional time required to awaken a patient is one of the main reasons for not extubating him or her in the operating room (or). conversely, transferring an intubated patient to recovery room (rr), prolonging the duration of anesthesia and intubation, in a limited environment in human resources, may lead to increased complications' rates. little is known about those time lengths and complications rates.

the additional time required to awaken a patient is one of the main reasons for not extubating him or her in the operating room (or). conversely, transferring an intubated patient to recovery room (rr), prolonging the duration of anesthesia and intubation, in a limited environment in human resources, may lead to increased complications' rates. little is known about those time lengths and complications rates. the primary objective was to evaluate the additional or occupancy time associated with awakening and extubation. secondary objectives were to assess the rate of post-extubation complications and the need for ventilatory support. this was a prospective multicenter observational study involving intubated patients who underwent surgeries in the operating theatres of the montpellier and clermont-ferrand university hospitals. anesthesia teams were asked to complete a form including data related to the patient, surgical procedure, anesthesia procedure (induction and recovery) and the occurrence of any complications during the procedure. a multivariate analysis was conducted on the full cohort, using a propensity score (iptw, inverse probability of treatment weighting) to account for imbalances between groups.

Eligibility criteria:
inclusion criteria: * adult (older than 18 years old) * patients admitted to any operative room of participating centre for a surgical or endoscopic procedure under general anaesthesia requiring endo-tracheal intubation * subjects must be covered by public health insurance * written informed consent from the patient or proxy (if present) before inclusion or once possible when patient has been included in a context of emergency. exclusion criteria: * patient extubated in intensive care unit * patient extubated during on-call hours (because of a reduced number of medical and paramedical staff) * patient extubated following cardiac surgery * refusal of study participation or to pursue the study by the patient * absence of coverage by the french statutory healthcare insurance system * protected person

Keywords: general anesthesia extubation intubation time complications
assessment of non-fasting vs. fasting lipid measures in diabetes patients

Conditions: Diabetes Mellitus; Normal Glucose Metabolism; Hyperlipidemia

Summary: this study will examine whether fasting and non-fasting lipid measures can provide similar clinical information in order to guide lipid management by primary physicians. it will compare fasting vs. non-fasting lipid measurements in patients with and without diabetes.


Eligibility criteria:
inclusion criteria: * park nicollet health services patients due for routine lipid measures exclusion criteria: * unwilling or unable to provide consent

Keywords: fasting lipid measures non-fasting lipid measures clinical decision-making ldl-cholesterol