Kornimate/medical-research-clean huggingface dataset:
atorvastatin versus simvastatin in the prevention of coronary heart disease (chd) in patients with known chd

Conditions: Cardiovascular Diseases

Summary: to investigate whether a long-term strategy to lower ldl cholesterol with atorvastatin as much as possible will improve prognosis in chd patients compared with a strategy reflecting current best clinical practice with simvastatin.


Eligibility criteria:
inclusion criteria: * previous myocardial infarction exclusion criteria: * women who are breast feeding or are pregnant
alimta and gemcitabine in non-small cell lung cancer

Conditions: Non-Small Cell Lung Cancer; Stage IIIB or IV

Summary: the aims of this study are: (1) to assess the safety and activity of gemcitabine plus alimta (pemetrexed) regimen (ga regimen) in patients with advanced nsclc patients in the context of a randomized trial, and (2) to compare the ga with the paclitaxel plus gemcitabine (pg regimen) in terms of toxicity and qol

patients with stage iiib or iv non-small cell lung cancer will be randomly allocated to receive: (a)pg regimen: paclitaxel 120 mg/sqm followed by gemcitabine 1,000 mg/sqm i.v. on days 1 \& 8 q 3 weeks; (b)ga regimen: gemcitabine 1,250 mg/sqm i.v. on day 1 (plus folinic acid 350 μg daily orally and vitamin b12 1,000 μg i.m. q 9 weeks), pemetrexed (alimta®) 500 mg/sqm i.v. on day 8 followed by gemcitabine 1,250 mg/sqm, q 3 weeks.

Eligibility criteria:
inclusion criteria: 1. patients with histologically or cytologically confirmed locally advanced (stage iiib) or metastatic (stage iv) nsclc 2. no previous adjuvant or palliative chemotherapy 3. no previous radiotherapy 4. presence of at least one unidimensionally measurable lesion (appendix 2) 5. ecog performance status of 0 or 1 (appendix 3) 6. charlson score ≤ 2 (appendix 4) 7. adequate bone marrow function (absolute neutrophil count ≥ 2 x 109/l, platelet count ≥ 100 x 109/l, and hemoglobin level ≥ 100 g/l), and adequate liver function (bilirubin level \< two times the upper limit of normal, ast and/or alt \< three times the upper limit of normal, prothrombin time \< 1.5 times control), and creatinine clearance ≥ 60 ml/min. 8. absence of symptomatic cns metastases (patients with cerebral metastases treated with brain irradiation may be included), severe cardiac arrhythmia or heart failure, second or third degree heart block or acute myocardial infarction within 4 months prior to study entry. 9. no major surgery or pleurodesis within 14 days prior to enrollment. 10. life expectancy of at least 12 weeks. 11. no previous or concurrent malignancy, except inactive non-melanoma skin cancer, in situ carcinoma of the cervix, or other cancer if the patient has been disease-free for more than 5 years. 12. written informed consent exclusion criteria: 1. any unstable systemic disease (including active infection, uncontrolled hypertension, unstable angina, congestive heart failure, serious cardiac arrhythmia requiring medication, hepatic, renal or metabolic disease). 2. patients with clinically significant effusions. 3. any other malignancies within 5 years that could affect therapy evaluation

Keywords: gemcitabine pemetrexed non-small cell lung cancer
impact of a multidimensional health education program on attention deficit hyperactivity disorder (adhd)

Conditions: ADHD

Summary: to measure the impact of a multidimensional health education program on patients' adherence to the healthy life style and behavioral therapy , and to correlate it with severity of adhd symptoms

attention-deficit/hyperactivity disorder (adhd) is a chronic neurodevelopmental disorder whose etiology is the result of complex interactions between multiple factors, including genetic, biological, and environmental influences. attention deficit hyperactivity disorder (adhd) is a condition that affects people's behavior. people with adhd can seem restless, may have trouble concentrating, and may act on impulse. symptoms of adhd tend to be noticed at an early age and may become more noticeable when a child's circumstances change, such as when they start school. most cases are diagnosed when children are 3 to 7 years old, but sometimes it's diagnosed later in childhood . a mean worldwide prevalence of attention-deficit hyperactivity disorder (adhd), or hyperkinetic disorder (hkd), of \~2.2% overall (range, 0.1-8.1%) has been estimated in children and adolescents (aged \<18 years) . regarding the prevalence of adhd in arabic countries, results from previous studies showed that it reached 9.4-21.8% in egypt ,and 11.6% in saudi arabia . several harmful consequences are associated with adhd, including deficient academic/work performance, social isolation, aggressive behavior (including delinquency and illegal acts), and even premature death from unnatural causes (such as accidents) undesirable lifestyle factors could contribute directly to inattention and/or hyperactivity symptoms, numerous mechanisms exist that could mediate such effects, such as secondary effects on energy level, immune function, and epigenetic change. study findings showed that children with adhd were approximately two times as likely to have a healthy lifestyle index that is lower than children without adhd multiple studies on alternative interventions for adhd aim at the prevention of adhd progression and targeting the underlying triggers (such as stress, poor sleep, overstimulation, technology or dietary plans). on the basis that making adequate lifestyle changes to minimize these triggers could contribute to better control of adhd symptoms .

Eligibility criteria:
inclusion criteria: * patients newly diagnosed with mild and moderate adhd not receiving medications or behavioral therapy, aged 6-9 years, and parents are motivated to participate in the lifestyle modification program. exclusion criteria: * children with severe form of adhd or with comorbid psychiatric disorders rather than disruptive behavior disorders, and children with an intelligence quotient score below 80 were excluded.

Keywords: adhd
social worker in an eye-care service

Conditions: Glaucoma

Summary: the purpose of this research study is to determine whether involvement with a social worker helps reduce distress, depression, and increase patient activation in participants over a 6 month intervention period. the study will also describe common barriers to care that participants face.

an appointment will be scheduled for participant to meet with a social worker. the appointment may happen on day of participant's scheduled clinic appointment or on another mutually decided upon date and time. should participant choose to participate, this first visit will be visit 1 for the study. visit 1: baseline informed consent will be obtained demonstrating an interest in participating. a visit with the social worker will take place during visit 1. this session will be held in a private office and allows participant time for discussion regarding any challenges, struggles and/or barriers they may be experiencing. the following baseline questionnaires/surveys will be administered: modified patient activation measure - measures participant confidence in taking care of their own health. distress thermometer - measures participant distress level during the past week. patient health questionnaire -measures depression symptoms and severity if any. clinical information will be taken from participant's medical record. there may be follow-up questions related to data if information is unclear or incomplete. upon completion of visit 1, participant will receive a satisfaction survey to evaluate how participant satisfaction with social worker interaction. social worker interventions: after visit 1 and before visit 2 the social worker will develop an intervention for participant during visit 1 appointment. as many calls or in person meetings participant requires will take place. there will be no limit and it will be determined by participant's needs. visit 2: follow-up after 6 months upon completion of participant's six month follow-up in the study, the following questionnaires/surveys will be administered: modified patient activation measure - measures how confident participant is at taking care of their own health. distress thermometer - measures how much distress participant has been experiencing in the past week. patient health questionnaire - measures if participant has symptoms of depression and the severity of those symptoms. satisfaction survey - measures how satisfied participant is with the social worker interaction.

Eligibility criteria:
inclusion criteria: * patients seen at wills eye hospital in the glaucoma service * glaucoma of any type, characterized by glaucomatous optic neuropathy and corresponding visual field (vf) defect * referred to staff social worker for intervention * ability to read, write, speak and understand english exclusion criteria: * none

Keywords: glaucoma social worker
study evaluating management of patients with community-acquired pneumonia (cap) or complicated skin infections

Conditions: Community Acquired Pneumonia (CAP); Complicated Skin and Skin Structures Infections (cSSSI)

Summary: this study will collect real-life data from patients with community acquired pneumonia (cap) or complicated skin and skin structure infections (csssi) to assess the burden of the disease, review the treatment pathways, evaluate how health resources are used and identify any areas of unmet medical needs. the aim of the study is to compare how patients who are admitted to hospital with cap or csssi are managed across europe. this will be done by collecting data to understand the patient and disease characteristics, current practice of treatment, and outcomes for the patient. overall 4000 patients will be recruited from 10 european countries.


Eligibility criteria:
inclusion criteria: * patients hospitalised with cap or csssi 1. cap: radiographically-confirmed bacterial pneumonia and requiring treatment with iv antimicrobials as start-up therapy 2. csssi: affecting deeper soft tissue and/or requiring significant surgical intervention or developing an abcess/ulcer/cellulitis in a lower limb and having at least two local signs and one systemic sign of csss and treatment with antimicrobials exclusion criteria: * patients already participating in clinical trials or any other interventional study. 1. cap: cap suitable for outpatient therapy with an oral antimicrobial agent. 2. csssi: uncomplicated sssi. skin and skin-structure infections with a high cure rate after surgical incision alone or after aggressive local skin care.

Keywords: community acquired pneumonia (cap) complicated skin and skin structures infections (csssi) complicated skin and soft tissues infections (cssti) antibiotics infection management use of resources mrsa prsp
exercise dose response for improving insulin sensitivity

Conditions: Obesity

Summary: many of the beneficial metabolic effects of endurance exercise training are not due to adaptations to weeks, months, or even years of training, but rather much is due to the response to the most recent exercise session(s). therefore, the investigators contend that lifestyle interventions for obese individuals should be tailored to optimize the metabolic effects of the most recent exercise session(s). but the "dose" of exercise necessary to evoke these beneficial responses is not known, and the mechanisms responsible for these improvements are poorly understood. the findings from these studies will: 1) establish the minimum "dose" of a single exercise session necessary to improve insulin sensitivity the next day in obese adults, 2) characterize the underlying metabolic factors responsible for the improvement in insulin sensitivity, and 3) assess the cumulative metabolic adaptations that occur over days, weeks, and months of a low-intensity/low-volume lifestyle exercise program. findings from these studies will provide valuable information for the development of lifestyle programs aimed at maximizing the key metabolic health benefits of each exercise session in obese patients.


Eligibility criteria:
inclusion criteria: * body mass index \[bmi\] = 30-45 kg/m2, weight stable (± 5 lbs in the past month), fasting blood glucose concentration must be \<125 mg/dl. exclusion criteria: * pregnancy, evidence of cardiovascular or metabolic disease, taking medications know to influence metabolism.

Keywords: insulin sensitivity fatty acid metabolism exercise
non-invasive evaluation of upper and lower body function with showmotion

Conditions: Osteoarthritis, Hip; Osteoarthritis, Knee; Osteoarthritis, Spine

Summary: it is very important to understand joint and body kinematics and muscles activity in clinical settings, which is relevant to identify issues related to the spine, the upper and lower limbs due to injury. in this study, the investigators will use an innovative platform, showmotion to establish baseline of shoulder, hip, knee and spine kinematics and muscles activity from 60 healthy volunteers.

upper and lower body functional evaluation is challenging and relevant to identify the issues related to injury. current technique still stays at visual observation. showmotion™ (ncs lab, carpi, italy) is an innovative platform that provides a comprehensive analysis to monitor motion patterns of the whole body using wise sensors, proprietary wireless inertial and magnetic units (mimu) developed by ncs lab (italy). using the data acquired from mimu and validated protocols for upper and lower limbs, showmotion is able to measure, objectify and store three dimensional kinematic variables highlighting underlying information and allowing an in-depth analysis of the movement in real time. compared to the classic motion analysis performed with cameras in special research laboratories, the showmotion™ technology allows the user to analyze the movements of the subjects in any place, quickly, and without the need to a long process of data analysis.

Eligibility criteria:
inclusion criteria: * healthy people (without musculoskeletal pathologies of the joint of interest) * age \> 18, \<65 * volunteers given written informed consent * ability to understand and execute instructions at all stages of the procedure exclusion criteria: * age \> 65, \< 18 * active infections * surgery at joint of interest * bmi (body mass index) \>30 kg/m2 * pregnancy

Keywords: osteoarthritis
effects of dynamic splinting on knee flexion angle after total knee arthroplasty: a randomized controlled trial

Conditions: Acquired Fixed Flexion Deformity of the Knee (Disorder)

Summary: to evaluate the effects of a knee flexion dynasplint orthosis on knee flexion angle after a total knee arthroplasty. sixty participants, who underwent a total knee arthroplasty, were randomly assigned in two groups: control group and dynasplint group.

post-surgical rehabilitation interventions following total knee arthroplasty consist mainly of stretching exercises to improve flexibility and prevent soft tissue fibroses around the joint, thus, avoiding contractures and providing increases in the range of motion at the knee joint. although knee manipulation and open arthrolysis may improve range of motion after total knee arthroplasty , the results have been variable and additional procedures are frequently necessary. studies demonstrated the effectiveness of dynamic orthoses in reducing joint contractures after orthopedic surgeries in various joints that require a long rehabilitation period. therefore, the purpose of the present study was to evaluate the effects of the knee flexion dynasplint orthosis (kfd) on the length of rehabilitation and range of knee flexion angle after total knee arthroplasty.

Eligibility criteria:
inclusion criteria: patients enrolled will have been schedule to receive first prosthesis of the knee: arthritis of the knee, dominated with pain painful, deformed, and/or unstable knees secondary to degenerative or inflammatory conditions exclusion criteria: fractures knee sepsis osteomyelitis or any orthopedic infection psoriasis knee joint neuropathy previous stroke or brain injury significant pathology acquired secondary to the surgery

Keywords: total knee arthroplasty knee flexion dynamic orthosis
clinical, genetic and epigenetic characterization of patients with fshd type 1 and fshd type 2

Conditions: Muscular Dystrophy, Facioscapulohumeral

Summary: the aim of the study was to compare the severity of illness between groups of patients (facio-scapulo-humeral dystrophy = fhsd1, fshd2 and patients both fshd1 and fshd2). despite advances in research on the subject, answers are still needed on these diseases. we also aim to determine whether the chromosomal genetic abnormality is involved in other diseases and the frequency of this mutation in the population of patients fshd. this study will increase our knowledge of the two forms of fshd who present a common pathophysiological mechanism and may occur together in the same family with a worsening of the clinical phenotype worsening . in addition, epigenetic differences between fshd type 1 and type 2 seems to have clinical consequences requiring appropriate management


Eligibility criteria:
inclusion criteria: * age ≥ 18 years and \<75 years * fshd patients 1 or 2 with or without genetic confirmation exclusion criteria: - patient with all conditions considered by the investigator interfering with the proper conduct of the study.
effects of chest physiotherapy and lungs squeezing technique in patients with chronic obstructive pulmonary disease.

Conditions: Chronic Obstructive Pulmonary Disease

Summary: chronic pulmonary obstructive disease refers to a group of lungs problems that includes blockage of airway and difficulty in breathing. it includes mostly emphysema, asthma and chronic bronchitis. chronic pulmonary obstructive disease is the third main cause of death in the whole world .the diagnosis of chronic obstructive pulmonary disease can be made by spirometer and the ratio of forced expiratory volume in 1 second over forced vital capacity (fev1/fvc) should be less than 70%. it shows severity of airway obstruction .first technique is chest physiotherapy, in which slow and gentle cupped hand slaps are given on effected lobe of lungs while second technique is lungs squeezing technique, in which 3-4 chest compressions are applied on the chest wall. the study design of this study will be randomized clinical trial. in this study non probability convenience sampling technique will be used to collect the data. data management and analysis will be done by using spss 25. this randomized clinical trial will include 48 patients with chronic obstructive pulmonary disease. their ages will be ranged from 40 to 60 years old male with the chronic obstructive pulmonary disease diagnosed with gold guidelines stage ii moderate to severe .the participants will be randomly allocated into two equal groups, the group i will receive chest physiotherapy, while the group ii will receive lungs squeezing technique for 20 minutes duration per session, three sessions per week, for a period of 4 weeks. the status of airway clearance, oxygen saturation and lungs volumes will be measured pre and post intervention in each training session.


Eligibility criteria:
inclusion criteria: * age 40_60 yrs. old male * copd diagnosed with gold guidelines stage 2 moderate to severe(14) * fev1/ fvc ratio below 70% * no use of beta 2 receptor agonist or anticholinergic drugs at least 6 hours before attending the study exclusion criteria: * unstable cardiovascular diseases * spo2 at rest below 88% * active pulmonary tuberculosis * neurological disorders

Keywords: percussion lungs squeezing technique spirometry chronic obstructive pulmonary disease
full thickness mucoperiosteal flap versus low level laser in orthodontic tooth movement acceleration

Conditions: Mesial Movement of Teeth

Summary: this study aimed to evaluate the effect of using full thickness mucoperiosteal flap (ftmpf) elevation only versus low level laser therapy (lllt) on acceleration of orthodontic tooth movement.

this study was a split mouth design study included 32 side according to sample size calculation. those sides were divided into 2 groups. group 1divided into (group 1a: 8 sides with ftmpf, group 1b:8 sides control). group 2(group 2 a: 8 sides with lllt, group 2b: 8 sides control). extraction of the first maxillary premolars followed by canine retraction in the extraction space with maximum anchorage were indicated. ftmpf was elevated from the mesial interdental papilla of maxillary canine to the mesial interdental papilla of second maxillary premolar. lllt was applied at 3,7,14,28.56 days of retraction. during retraction study model for all patients were taken at 2ed, 6th, 14th,16th weeks and at the end of retraction (i1,i2,i3,i4,i5 or overall interval). 3d laser scanning and digital superimposition was done to measure the rate of canine retraction and anchorage loss.

Eligibility criteria:
inclusion criteria: * o free of any syndromes affecting the head region or any craniofacial injuries. * no history of previous orthodontic treatment * all of the permanent dentition present excluding third molars. * good oral hygiene before starting treatment. * cases indicated for extraction of the maxillary first premolars and canine retraction into the extraction space with maximum anchorage. * malocclusion cases that allow initial stage of leveling and alignment without extraction. exclusion criteria: * o patients with systemic diseases especially bleeding disorders and osteoporosis. * history of administration of corticosteroids, exogenous hormones and non-steroidal anti-inflammatory drugs (all drugs interfere with otm). * presence of previous history of oral surgeries in maxillary arch.
the detection of chronic obstructive pulmonary disease in patients with diabetes mellitus

Conditions: Diabetes Mellitus

Summary: "background: chronic obstructive pulmonary disease (copd) is an ongoing lung condition caused by damage to the lungs. the damage results in swelling and irritation, also called inflammation, inside the airways that limit airflow into and out of the lungs. diabetes can worsen the progression and prognosis of copd.

if inflammation cause in lungs breathing process become disturbed. if damages the air sacs (alveoli) that cause emphysema. copd mainly starts with asymptomatic patients who do not realize that they have it. it mostly affects older people or middle-aged. its symptoms become develop slowly but with the time they become worsen, patient change their life style and treatment become helpful to prevent from chronic disease the detection of chronic obstructive pulmonary disease in patients with diabetes mellitus. methods: the study design was cross sectional and carried out in hospital, lahore from july 2024 to jan 2024. all eligible patients who were diabetes mellitus in the study through random sampling technique.

Eligibility criteria:
inclusion criteria: * age: 30-65 years gender: both * male and female * at least 5-10 year history of diabetes mellitus * chronic obstructive pulmonary disease exclusion criteria: * patients who smoke prolong. * patient having other diseased (asthma, lung carcinoma). * patients having acute respiratory distress syndrome (ards)."