Kornimate/medical-research-clean huggingface dataset:
awake prone position in patients with covid-19

Conditions: Covid19

Summary: although prone position is widely used in awake patients with covid-19 associated with supplemental oxygenation, high flow nasal catheter, or noninvasive ventilation, few studies are attesting to its real benefits on physiological variables or intubation rate. awake patients dependent on supplemental oxygen may have different responses to pp about peripheral oxygen saturation, heart rate, and respiratory rate. such responses may be permanent, transient, or even absent. we believe that the response to pp can be a predictor of the need for admission to the icu. this study aimed to evaluate the acute effects of different types of response to the prone position in patients awake with covid-19.


Eligibility criteria:
inclusion criteria: patients with a confirmed diagnosis of covid-19, through tests based on pcr and chest tomography with suggestive findings, spontaneously ventilating, dependent on supplemental oxygen. the study included patients with: (1) age ≥ 18 years, (2) peripheral oxygen saturation less than 92% under supplemental oxygen administration equal to or greater than 6 l / min through a nasal catheter or reservoir mask; (3) no use of niv or high-flow nasal catheter; (4) continuous monitoring with pulse oximeter; (5) mental status that allowed to follow the instructions; and (6) able to tolerate pp with minimal assistance. - exclusion criteria: * hemodynamic instability, severe obesity, or who were unable to tolerate and cooperate with the performance of pp
phase ii copanlisib in relapsed/refractory diffuse large b-cell lymphoma (dlbcl)

Conditions: Diffuse, Large B-Cell, Lymphoma

Summary: to assess the potential efficacy (in terms of objective response) of single agent copanlisib in patients with relapsed or refractory diffuse large b-cell lymphoma (dlbcl) and assess the relationship between efficacy and a potentially predictive biomarker


Eligibility criteria:
inclusion criteria: * diagnosis of diffuse large b-cell lymphoma (dlbcl) (de novo or dlbcl transformed from follicular lymphoma on the basis of a tissue biopsy). * received at least one prior therapy for aggressive non-hodgkin's lymphoma (nhl) (dlbcl). * received chop (cyclophosphamide, doxorubicin, vincristine, and prednisone) + rituximab or equivalent regimen. * patients must have measurable disease. * not eligible or not willing to receive the high-dose (myeloablative) chemotherapy (hdc) and stem cell transplant (sct). * a fresh tumor biopsy collected during screening and /or archival tumor tissue collected after the last relapse/disease progression. * eastern cooperative oncology group (ecog) performance status (ps) ≤ 2. * left ventricular ejection fraction (lvef) ≥ the lower limit of normal (lln) for the institution. (as per local standard of care) as measured by echocardiogram (echo) or multiple gated acquisition (muga) scan. * adequate bone marrow, liver and renal function. exclusion criteria: * any of the following as the only site(s) of disease: palpable lymph nodes not visible on imaging studies, skin lesions, or bone marrow involvement only. * active ctcae (common terminology criteria for adverse events) grade 3/4 infection. * current central nervous system (cns) involvement by lymphoma. * unstable angina (angina symptoms at rest), new-onset angina (begun within the last 3 months). myocardial infarction within the past 6 months before start of study treatment. * uncontrolled arterial hypertension despite optimal medical management (per investigator's opinion). * type i or ii diabetes mellitus with hba1c \> 8.5% at screening. * new york heart association (nyha) class iii or iv heart disease. * history or concurrent condition of interstitial lung disease of any severity and/or severely impaired lung function (as judged by the investigator). * patients who previously received therapy with copanlisib or other pi3k inhibitors are not eligible for enrollment.
impact of reading on endogenous oxytocin system of preterm infants

Conditions: Premature Infant Disease; Development, Infant

Summary: the purpose of this study is to learn how early language exposure may be related to changes in dna in parents and their premature infants. while a person's genetic code is determined at the time of conception, the way that some genes are expressed in the body can be changed even after an individual is born. these changes are called epigenetic changes. in this study, the investigators want to learn about the epigenetic changes that happen after a premature baby is born and whether a parent's interaction with their baby can influence these epigenetic changes. the investigators will look at epigenetic changes by collecting saliva samples from parents and their preterm babies, here defined as babies born at \<33 weeks gestation. specifically, the investigators will be looking at salivary levels of dna methylation of the oxytocin receptor gene (oxtrm). the investigators will track changes in oxtrm levels over time in parents and their babies and see if these levels change in relation to how much time parents spend with their babies and how much time they spend reading to their babies. the investigators will ask mothers and, if desired, their partners to read to their babies for at least 15 minutes per week. the investigators will ask them to track time spent with the baby and reading time on a log, and will also measure word count with a commercially-available lena device. the investigators will use logistic regression analysis to identify the independent association between oxtr dna methylation and time spent with parent(s) and word count.

student's t-test and pearson's chi-square tests will be used to compare continuous and categorical variables, respectively. logistic regression analysis will used to identify the independent association between oxtr dna methylation and time spent with parent(s) and word count. variables with p≤0.20 in the univariate analysis will be entered into a stepwise logistic multivariate regression model. odds ratios with 95% confidence intervals will be calculated. p value of less than 0.05 will be considered statistically significant. a protocol modification was submitted to and approved by the university of virginia irb due to slower than expected participant enrollment. the protocol was modified such that: * enrollment of \<33 week instead of \<32 week infants was permitted * enrollment was permitted through the first 2 weeks after birth instead of through the first 1 week after birth

Eligibility criteria:
inclusion criteria: * infants \<33 week gestational age at birth * mother must be able to visit at least once per week * mother or primary caregiver must participate; father or secondary caregiver may participate as well * mother must commit to minimum of 15 minutes reading at least once per week exclusion criteria: * infant with life-limiting conditions * mother is non-english speaking * illiteracy of mother
premapiv : intravesical pressure variation at different bladder instillation volumes in newborn children

Conditions: Intensive Care Unit Syndrome

Summary: abdominal compartment syndrome (asc) is defined by an intra abdominal hypertension (iah) associated with a new organ failure. the occurrence of this syndrome is not well known in infants. preterm birth is frequently associated with gastrointestinal complications, particularly necrotizing enterocolitis. in this pathology it is likely that the intra abdominal pressure (iap) increases and can participate in the occurrence of organ failures. newborn, in particular with digestive malformation as diaphragmatic hernias, gastroschisis, could themselves be suffering from this syndrome. it would be interesting to make early diagnosis in order to optimize the management of these children. this requires reliable measurements methods and standards. intravesical pressure (ivp) is the most reliable validated indirect method to measure intra-abdominal pressure. in order to measure the ivp, the bladder must contain a minimum of liquid. however, using inappropriate volumes could give erroneous iap readings. the optimal amount of saline to inject in older children, determined from pressure-volume curves study is 1 ml/kg. in preterm and term infants, this volume appear extremely low (e.g. 0 8cc if taking a child to 800 g). the question that arises is whether this quantity is sufficient to obtain reliable and reproducible measurements of ivp in preterm and term.


Eligibility criteria:
inclusion criteria: * preterm or term newborn admitted in paediatric intensive care unit * with an urethral catheter * consent signed by parents exclusion criteria: * weight \> 4.5 kg * urinary tract or bladder pathology
otoacoustic emission suppression study

Conditions: Neonatal Hearing Loss

Summary: the focus of this project is on a physiologic auditory response called the medial olivocochlear reflex (mocr) that assesses peripheral neural function. while neural hearing loss is a significant auditory disorder in patients of all ages, more than 50% of newborn infants are screened with a technology that is not sensitive to abnormalities in neural function. the development of a time-efficient and sensitive test system to assess the mocr will provide significant benefit to infants and patients of all ages with neural deficits who would otherwise go undetected.

the objective of this study is to develop an optimized hearing testing method using otoacoustic emissions, that can be used to efficiently assess peripheral neural function (including retrocochlear disorders) using the medial olivocochlear reflex (mocr). measuring neural function via the mocr. this reflex has been shown to be abnormal in patients with neural disorders. the focus of this project will be the development of a screening method that incorporates oae screening and measurement of the mocr in the same test procedure. the target population in the proposed research is infants, particularly those in environments where auditory brainstem response (abr) screening is not performed routinely. addition of the mocr to screening where abr is not performed will address the shortcoming of oae screening which misses neural forms of hearing loss.

Eligibility criteria:
inclusion criteria: * normal middle-ear function * present teoaes. exclusion criteria: * atresia or other external ear abnormalities not allowing recording of oaes
the effect of review of a decision aid prior to the appointment on decisional conflict compared to usual care in the treatment of trapeziometacarpal (tmc) arthritis

Conditions: Trapeziometacarpal Arthritis

Summary: the investigators plan a prospective randomized controlled study that compares whether the use of a decision aid results in different scores on variables reflective of the decision-making process, behavior, health outcomes, communication, and healthcare system.

decision aids (shared decision making tools-websites, videos, or pamphlets) are interventions to prepare patients to make more informed decisions and satisfying decisions that match their preferences and values. with greater understanding of the risks and benefits of the treatment options patients may make a more informed choice. decision aids - delivered online, on paper, or on video - increase patient participation in the decision-making process,1 and can result in a decrease in discretionary surgery for knee osteoarthritis, herniated disk, and benign prostatic hypertrophy.2-4 they also reduce decisional conflict. relatively few studies have investigated the influence of decision aids in orthopedic or hand surgery. decision aids might affect decisional conflict, satisfaction, and outcomes in hand surgery where many treatments are discretionary and address quality of life. utilizing the ottawa decision support framework- an evidence-based, practical theory used to guide the development of decision aids - and the international patient decision aid standards criteria the investigators developed a decision aid for trapeziometacarpal arthritis.

Eligibility criteria:
inclusion criteria: * at least 18 years of age * english-speaking * diagnosis of trapeziometacarpal (tmc) arthritis exclusion criteria: * prior surgical intervention for trapeziometacarpal (tmc) arthritis * previously accessed or used the online tmc arthritis decision aid (da)
icbt for depression in older adults

Conditions: Internet Treatment; Active Control

Summary: the study was a randomized controlled trial investigating treatment effects against an active control condition. 101 self-recruited participants, aged 65 to 88 years, were included. the intervention was a 10-week internet-based tailored cbt protocol consisting of 6-10 pre-defined modules tailored to patient profile and preferences. participants in the treatment group benefitted more than participants in the control condition on almost all measures with moderate between-group effect-sizes.

depression in older adults is associated with poorer functioning, worsened cognitive impairment and disability, as well as medical illnesses. it can also increase the risk of suicide and is associated with a high usage of medical services. it is common that depressive symptoms co-occur with other psychiatric symptoms (i.e. anxiety). in the case of co-morbidity, patients present with greater difficulties and the problems tend to be more persistent. together this stresses the importance of developing effective treatments. psychological treatments can be effective but are rarely offered and thus alternative modes of treatment delivery should be considered such as internet interventions. design: the study was a randomized controlled trial investigating treatment effects against an active control condition. participants: 101 self-recruited participants, aged 65 to 88 years, were included. intervention: the intervention was a 10-week internet-based tailored cbt protocol consisting of 6-10 pre-defined modules tailored to patient profile and preferences. measurements: depression, anxiety, life quality and cognitive decline were assessed through self-reported measures together with an online test of cognitive flexibility. results: participants in the treatment group benefitted more than participants in the control condition on almost all measures with moderate between-group effect-sizes. cognitive decline improved during treatment and neither cognitive decline, nor cognitive flexibility predicted treatment outcome. conclusion: the study adds to the evidence of internet-delivered psychological treatment for depression, with or without psychiatric comorbidities, in older adults. it also highlights the possibility of perceived cognitive decline as being part of the clinical picture and reversible, rather than reason for exclusion from for psychological treatment.

Eligibility criteria:
inclusion criteria: * age 65 years or older * presence of depressive symptoms * living in sweden * access to the internet and a computer on a regular basis. exclusion criteria: * heightened suicidal ideation * drug or alcohol abuse or dependency * other ongoing psychological treatment * severe psychiatric or cognitive problems * unstable psychopharmacological medication

Keywords: depression internet-delivered cognitive-behavior therapy older adults
the effect of ips-ma- a modified early supported employment intervention for individuals with mood or anxiety disorders

Conditions: Affective Disorder; Major Depressive Disorder; Bipolar Disorder; Anxiety Disorder

Summary: the aim of the present study, is to evaluate the effect of a supported employment intervention, ips-modified for people with mood and anxiety (ips-ma) on employment or education, when offered to people with onset mood or anxiety disorders who are not likely to be able to return to work within three month. the hypothesis is that the ips-ma method is associated with a shorter recovery period and more people returning to work or education, compared to treatment as usual.

background: the ips-ma method is a modified individual placement and support (ips) intervention, aiming at supporting people with mood or anxiety disorders regain their workability and return to work or education. previous studies have showed, that ips has an effect on employment when offered to people with severe mental illness. further studies are crucial to demonstrate whether the modified ips, the ips-ma method, has an effect when offered to people with mood or anxiety disorders who are not yet chronified. methods/design:the trial design is a randomized, assessor-blinded, clinical trial of the ips-ma method in addition to treatment as usual compared to treatment as usual alone for 326 participants diagnosed with a mood or anxiety disorder, living in the capital region of denmark. the primary outcome is competitive employment or education. secondary outcomes are days of competitive employment or education, disease symptoms, level of functioning, and quality of life at follow-up 12 and 24 months after baseline.

Eligibility criteria:
inclusion criteria: * diagnosed following the international classification of diseases (icd-10) criteria of affective disorder (f30-39) or anxiety disorder (f40-41) * not able to work within 3 months * associated with the mental health center copenhagen, frederiksberg, hillerød, hvidovre or ballerup * only having had contact to the mental health services during the past 3 years * having had competitive employment or attending a study within the past two years. * has returning to work or education as an important goal * under the age of 60 * able to speak, read and understand danish * has given informed consent verbally and in writing exclusion criteria: * a somatic disease that effects the workability * substance og alcohol abuse * have a guardian or a forensic psychiatric arrangement * not given informed consent

Keywords: supported employment individual placement and support workability return to work
the effect of radiofrequency ablation of genicular nerves on postural stability in patients with knee osteoarthritis

Conditions: Osteoarthritis, Knee

Summary: in advanced knee osteoarthritis, postural stability is also disturbed. there are some concerns about performing radiofrequency ablation to genicular nerves since this may further decrease the postural stability of the patient. the aim of this study is to see if application of genicular radiofrequency causes a significant change in postural stability.


Eligibility criteria:
inclusion criteria: * stage 3 and 4 knee osteoarthritis according to kellgren-lawrance scale * knee pain more than 3 months exclusion criteria: * neurological diseases such as polyneuropathies * presence of severe psychiatric disorders * hemodynamic instability * history of any surgery from the knee

Keywords: osteoarthritis radiofrequency ablation
investigating the acute effects of increasing glucagon exposure in healthy participants

Conditions: Glucose Metabolism; Glucagon

Summary: in this study the investigators will investigate the acute effects of increasing glucagon exposure on metabolic parameters in healthy participants. participants will participate in one study day. after initial baseline blood samples, a three-hour intravenous infusion with glucagon will be initiated. the infusion rate will be increased every 30 minutes.

ten participants with normal health will be included, and each participant will participate in one study day. participants will arrive after an overnight fast and will be placed in a hospital bed in a semi-recumbent position. in each antecubital vein an intravenous catheter will be placed; one for administration of glucagon and one for blood sampling. two baseline blood samples will be drawn before the glucagon infusion is started. the glucagon infusion rate will be increased every 30 minutes (infusion rates are 0,01 ng/kg/min, 0,1 ng/kg/min, 0,5 ng/kg/min, 1,0 ng/kg/min, 10 ng/kg/min and 50 ng/kg/min). blood samples for the analysis of plasma glucagon, glucose, insulin, c-peptide etc. will be drawn every 15 minutes.

Eligibility criteria:
inclusion criteria: * capable of understanding the participant information and signing the consent form * between 25 and 70 years of age at the time of screening * body mass index (bmi) ≤ 25 kg/m2 at the time of screening exclusion criteria: * enrolment in other research projects that might interfere with the study * diabetes diagnosis (type 1 and 2) * pregnancy or breastfeeding * use of medications which, in the opinion of the investigator, may jeopardise participant's safety or compliance with the protocol * impaired liver function defined as either alanine aminotransferase (alat) and/or aspartate aminotransferase (asat) ≥ 2 times normal values * kidney disease defined as serum creatinine levels ≥ 126 μmol/l for male and ≥ 111 μmol/l for female * inadequately treated blood pressure at screening defined as repeated resting blood pressure outside the range 90-150 mmhg for systolic and 50-100 mmhg for diastolic * active or recent malignant disease * current or history of severe alcohol use or drug/chemical abuse as per investigator's judgement * any chronic disorders or severe diseases which, in the opinion of the investigator, might jeopardise participant's safety or compliance with the protocol
a pilot study on exercise after achilles tendon rupture

Conditions: Achilles Tendon Rupture

Summary: the purpose is to study the effect of early neuromuscular exercise (nemex) versus conventional treatment (late exercise) in patients with acute non-operative achilles tendon rupture (atr).

there is currently no consensus on treatment for achilles tendon rupture with regard to surgical or non-surgical treatment. in addition, the optimal time to start exercise treatment after the injury, with or without surgery, is not well understood. animal studies show positive effects of early mobilization in tendon healing. neuromuscular exercise has shown better effects than strength exercise in people with knee injury or knee disease. there are few studies in humans focusing on exercise as treatment, without surgical intervention, after atr.

Eligibility criteria:
inclusion criteria: 1. men and women 18 - 60 years. 2. the patient should before the achilles tendon rupture have been able to walk independently without aid, walk without limping, run/jog and be able to jump on one leg 3. the patient shall be able to read, understand and to assimilate the written information about the study. exclusion criteria: 1. previous achilles tendon rupture 2. acute achilles tendon rupture, more than 5 days. 3. medical restrictions regarding physical exercise, not related to the achilles tendon rupture

Keywords: achilles tendon rupture non-surgical treatment exercise neuromuscular training
neutrophil side fluorescent light (neu-sfl) in covid-19 patients

Conditions: COVID-19

Summary: recently, a study showed that markers of neutrophil extracellular traps formation, a mechanism corresponding to neutrophil activation, were increased in patients who died of covid 19 compared with survivors. the investigators propose to analyze the neu-sfl parameter, obtained automatically on the sysmex™ blood count machine (sysmex corporation, kobe, japan) and which is considered as a reflect of neutrophil extracellular traps formation, in these two groups of patients. the aim was to evaluate whether this parameter could be used to predict the risk of death related to covid 19.


Eligibility criteria:
inclusion criteria: * hospitalization for covid 19 in 2021 exclusion criteria: * patients who refused the use of their data

Keywords: covid-19 neutrophil extracellular traps (nets)