Kornimate/medical-research-clean huggingface dataset:
an observational study to identify new health problems arising after an intensive care unit admission in people with acute respiratory distress syndrome in the united states

Conditions: Acute Respiratory Distress Syndrome (ARDS); Post Intensive Care Syndrome (PICS)

Summary: this is an observational study in which data already collected from people with acute respiratory distress syndrome (ards) admitted to an intensive care unit (icu) are studied. ards is a life-threatening condition in which fluid builds up in the lungs making breathing difficult. in observational studies, only observations are made without participants receiving any advice or any changes to health care. people who are admitted to icu for serious illnesses, like ards, often experience new health problems during and after their icu stays. these health problems that may include physical, mental, and/or emotional disorders, are called post-intensive care syndrome (pics). identifying these new health problems early can help people by timely treatments and care. in this study, researchers want to identify any health problems that arise after icu admission in people with ards in the united states (us). to do this, researchers will collect information on health problems, treatments, medicines, and healthcare visits in people with ards, 1 year before and after an icu admission. they will then look to see whether the health problems are in areas that have been described as the post intensive care syndrome (pics). in addition, they will measure healthcare related costs in the one year after admission and compare it to the one year prior to admission. researchers will also compare this information with data collected for people with pneumonia who did not require icu admission. this will help them to identify any new health problems arising due to icu stays. the data will come from participants' medical claims information stored in the optum clinformatics data mart database from 2016 to 2022. the claims data will only be collected for people in the us. researchers will collect data from participants admitted to icu for ards for a maximum of 1 year before and after their stay.


Eligibility criteria:
inclusion criteria: * continuous coverage of at least 365 days (\>= 1 year) pre-index date for the cohort * age \>= 18 years * not seen outside the healthcare system exclusion criteria: * none
effectiveness and safety of high frequency electrotherapy in patients with meibomian gland dysfunction

Conditions: Meibomian Gland Dysfunction

Summary: this study is a prospective randomized double-masked sham-controlled clinical trial to determine the clinical improvement, safety and mechanism of action by evaluation inflammatory cytokine, and amount of bacteria and demodex, after high frequency electrotherapy or called quantum molecular resonance treatment in patients with meibomian gland dysfunction.

the rexon-eye is quantum molecular resonance device which was published in previous study that could treat meibomian gland dysfunction. participants in this study will have rexon-eye treatment at baseline (after recording of baseline characteristics and giving and inform consent), day 7, day 14, day 21. the evaluation for most parameter except for safety parameter will be recorded at baseline, 1 month after last treatment, and 2 mont after last treatment. safety parameter will be recorded in all 4 follow-ups. during study, all participant will instructed to use same artificial tears for four time a day.

Eligibility criteria:
inclusion criteria: 1. able to read, understand and sign an informed consent form 2. \> 18years of age 3. able and willing to comply with the treatment/follow-up schedule and requirements 4. presence of meibomian gland on each lower eyelid's meibography 5. current diagnosis of stage 1-4 of mgd in both eyes, according to the international workshop on meibomian gland dysfunction: report of the subcommittee on management and treatment of meibomian gland dysfunction exclusion criteria: 1. contact lens wearer within the past 1 month and throughout the study 2. recent ocular surgery or eyelid surgery within the past 6 months 3. neuro-paralysis in the planned treatment area within the past 6 months 4. current use of punctal plugs 5. pre-cancerous lesions, skin cancer or pigmented lesions in the planned treatment area 6. uncontrolled infections or uncontrolled immunosuppressive diseases 7. subjects who have undergone refractive surgery within the past 6 months 8. patients who had ocular infection within 6 months 9. pregnancy and lactation 10. any condition revealed during the eligibility screening process whereby the physician deems the subject inappropriate for this study 11. declared legally blind in one eye 12. lipiflow treatment, or any equivalent treatments, within the past 12 months
strain echo in acute heart failure

Conditions: Heart Failure

Summary: the purpose of this project is to evaluate the utility of left ventricular strain as part of the assessment of patients in the emergency department with acute heart failure (hf). the central hypothesis of the investigation is that left ventricular strain will prove to be a treatment response variable in patients with acute hf. patients who are being treated for acute hf with intravenous (iv) vasoactive medications (diuretics, vasodilators, inotropes) will be eligible for enrollment. patients who give written consent will receive a focused bedside echocardiogram within 30 minutes of the initiation of therapy for acute hf. images that are captured during this echocardiogram will be interpreted by a blinded cardiologist offline. 23 hours after this initial focused echocardiogram a member of the study team will perform a follow-up focused echocardiogram, capturing the same images that will then be interpreted by a blinded cardiologist offline. offline analysis will be performed using a proprietary software package from general electric called automated function imaging (afi). the afi software will be used to calculate longitudinal strain of the left ventricle (lv). regional and global strain values will be calculated for each focused echocardiogram for each subject. it is our hypothesis that lv strain will demonstrate improvements from the initial echocardiogram to the follow-up echocardiogram, unlike other echocardiographic indices in hf such as lv ejection fraction.


Eligibility criteria:
inclusion criteria: * 18 years of age or greater * ability for the patient to provide written informed consent * planned treatment with intravenous (iv) medications (diuretics, vasodilators, inotropes) for acute hf exclusion criteria: * need for emergent, resuscitative intervention (e.g., cardiopulmonary resuscitation, endotracheal intubation) * rapid atrial fibrillation or other arrhythmia that requires iv rate or rhythm control * plans for emergent percutaneous coronary intervention (pci) from the ed * pregnancy * incarceration * history of cardiac transplant * planned transfer to another institution

Keywords: echocardiography
efficacy of light therapy device luminette® in major depressive disorder

Conditions: Major Depressive Disorder; Unipolar Depression

Summary: this study evaluates the addition of light therapy with luminette device to usual treatment (antidepressant drug and psychotherapy) in the treatment of major depressive disorder (mdd). half of the participants will receive active light therapy with luminette device while the other half will receive placebo light therapy with luminette placebo device.

major depressive disorder (mdd) is a world wide spread disorder. according to the world health organization, mdd affects more than 300 million people of all ages in the world. treatments of mdd include pharmacological treatment and psychotherapy. pharmacological treatments, mostly serotonin selective reuptake inhibitors, have a delayed onset of action, require long-term treatment and have partial efficacy. in fact, only one third of patients respond to the first antidepressant treatment and two-third after multiple trials. so, there is a need for new treatment strategy. light therapy is a well established non pharmacological treatment of seasonal affective disorder, a clinical subtype of affective disorder characterized by recurrent episodes of depression occurring with a seasonal pattern. patients are exposed to artificial light for a variable duration and intensity. although the precise mechanism of bright light therapy remains unknown, it is thought to act through the eyes by activating the suprachiasmatic nucleus, the principal circadian pacemaker.

Eligibility criteria:
inclusion criteria: * mdd diagnosis according to the diagnostic and statistical manual of mental disorders i-v (dsm-iv), assessed by means of the mini neuropsychiatric international interview (mini). * age between 18 and 60 years. * affiliation with a welfare scheme. * complete information on the study received and written informed consent signed exclusion criteria: * diagnosis of a progressive psychiatric disorder (except mdd and anxiety disorder) according to axis i of the dsm-iv, assessed by means of the mini. * absence of routine care for mdd. * previous or current lt treatment. * seasonal affective disorder. * high suicide risk, assessed by means of the mini * ongoing neurological disease. * retinal pathology. * participation in another study. * patient impairment leading to difficulty participating or impossibility or inability to understand the information provided on the study. * persons cited in articles l. 1121-5 to l. 1121-8 of the french public health code: pregnant women, parturient or breastfeeding mothers, persons deprived of their liberty by a judicial or administrative decision, persons under psychiatric care under duress, persons admitted to a health or social establishment for other goals than research, minors, adults subject to a legal protection, adults who are unable to express their consent and who are not subject to a legal protection measure.

Keywords: light therapy
phenylephrine versus norepinephrine in septic shock

Conditions: Septic Shock

Summary: clinical studies evaluating the clinical use of phenylephrine in septic shock are lacking. the present study was designed to compare the effects of norepinephrine and phenylephrine on systemic and regional hemodynamics in patients with catecholamine-dependent septic shock.


Eligibility criteria:
inclusion criteria: * clical diagnosis of septic shock * norepinephrine to maintain mean arterial pressure between 65 and 75 mmhg despite adequate volume resuscitation (pulmonary artery occlusion pressure = 12-18 mmhg and central venous pressure = 8-12 mmhg). exclusion criteria: * age \< 18 years * pregnancy * present or suspected acute coronary artery disease * present or suspected acute mesenteric ischemia.

Keywords: septic shock sepsis norepinephrine phenylephrine
naps: non-awake versus awake placement of spinal cord stimulators

Conditions: Chronic Pain; Sciatica; Failed Back Surgery Syndrome

Summary: the primary objective is to demonstrate the safety and efficacy of a non-awake implantation method (emg neuromonitoring) of a scs paddle lead as compared to an awake implantation method (with local anesthesia and patient feedback).this is a post-market, prospective, multicenter, parallel designed, non-randomized, non-blinded, 6-month study. a minimum of 50 patients will be implanted from up to 4 active sites, coordinated by a single lead investigator. patients who have had a successful scs trial and are indicated for permanent implantation will be approached to participate in this study prior to permanent implantation. patients will be recruited and enrolled by physicians at any one of the involved sites. each investigator will only use one method (awake or non-awake) according to his/her typical practice. patients will receive treatment from their enrolling physician.


Eligibility criteria:
inclusion criteria: * patients who have had a successful spinal cord stimulation trial and are indicated for permanent implantation at a participating facility. * sign informed consent exclusion criteria: * \< 18 years of age
diabetes companion app for adults with diabetes and their carers

Conditions: Diabetes; Diabetes Mellitus, Type 2; Diabetes Mellitus; Diabetes Type 2

Summary: diabetes self-management support, education, and training are increasingly being delivered through digital technology such as mobile phones. this protocol aims to evaluate the effectiveness of glow, a diabetes companion app with a conversational agent.

adopting a healthier lifestyle and disease self-management skills is critical to reducing the risk of diabetes-related complications. internationally, and in singapore, the majority of people with diabetes report not having received structured diabetes education, while others have the knowledge and fail to apply it in their daily lives. key self-management behaviours recommended by the american association of diabetes educators include physical activity, healthy diet, blood glucose monitoring, and medication adherence, but equally important is healthy coping to maintain a positive attitude toward diabetes management. life-long patient education and continuous empowerment are paramount to successful self-management in people with diabetes, as recommended by evidence-based diabetes management guidelines. in addition to patients, their informal carers often play an important role in the management of diabetes. as such, diabetes education for informal carers is essential to achieve the best possible diabetes outcomes in the patient. there are hundreds of diabetes apps available for the public to download and use, but few are rigorously evaluated for clinically meaningful outcomes. we designed glow, a diabetes companion app with a conversational agent, to support people with diabetes and their carers with self-management and knowledge.

Eligibility criteria:
inclusion criteria: 1. diagnosed with type 2 diabetes and attending tan tock seng hospital (ttsh) diabetes clinic or caring for a person with type 2 diabetes 2. 21 years old or above 3. able to speak and read english 4. singapore nationality or permanent resident or foreign domestic worker (for carers) 5. own a personal mobile device which can download study mobile app 6. access to the internet exclusion criteria: 1. are unable to consent; 2. are pregnant (for patients) 3. received formal training in medicine or allied health services

Keywords: conversational agent chatbot diabetes literacy diabetes knowledge self management digital therapeutics digital health
exploring relationships among balance performance, cognitive dysfunction, affective dysregulation, and community integration in veterans with traumatic brain injury (tbi)

Conditions: Traumatic Brain Injury; TBI

Summary: the overarching goal of the proposed study, named synergy, is to explore relationships among balance performance, cognitive function, affective dysregulation, as they relate to the community re-integration in veterans with tbi. the synergy study findings can aid in the development of a better outcome models for the clinicians in facilitating effective community re-integration in veterans with tbi

examine if there are associations among balance, cognitive and affective function during multitasking activities in veterans with the diagnosis of tbi. to determine if an association exists between balance performance and the degree of community re-integration in veterans with tbi. to determine which of the three systems, balance performance, cognitive dysfunction or affective dysregulation, is the strongest predictor of community re-integration in veterans with tbi.

Eligibility criteria:
exclusion-inclusion criteria inclusion criteria: enrolled participants will be veterans with tbi between18 to55 years of age. we identified a wide age range in order to include veterans from the iraq and afghanistan conflicts, as well as veterans of the vietnam war. this feature of the inclusion criteria is important since barriers to community re-integration may be affected by impaired balance, cognitive dysfunction, affective dysregulation, across the age spectrum. consequently, the study findings will potentially benefit not only young veterans, but also middle aged veterans. the military acute concussion evaluation (mace): we will use mace scores of 21/30 to ensure the participants have the cognitive ability to understand our study protocol, and therefore, participate voluntarily in the study. 62 exclusion criteria: we will use an exclusion criteria of 12/24 on the dynamic gait index (dgi) to ensure that patients are ambulatory either with or without the use of assistive device to be able to measure dynamic balance accurately.16 past medical history: the following diagnoses will be cause for exclusion -- peripheral neuropathy, parkinson syndromes, multiple sclerosis; bipolar, schizophrenia, seizure or psychiatric illnesses. medically stable patients: it is essential to minimize future medical adverse conditions and minimize the risk of drop out. therefore, no patient shall be considered for enrollment if they do not meet inclusion/exclusion criteria or have not been recommended by the polytrauma staff at va dcmc. the result of vha tbi comprehensive evaluation electronic template will be reviewed following irb approved and hipaa compliant data collection procedures. the tbi diagnosis will be obtained from patient's chart review of problem section and physician's notes. -

Keywords: dual/multitasking executive function affective function balance
cognitive behavioral therapy for early-onset depression

Conditions: Major Depressive Disorder; Dysthymic Disorder

Summary: depression is a debilitating illness affecting large numbers of young people. in this study, children and adolescents ages 10 to 17 meeting criteria for clinical depression will participate in a 15-session group therapy (cognitive behavioral therapy or cbt) that teaches strategies for overcoming depressed mood. for half the participants, their parents will also participate in a parent group. by studying the role of parental involvement, we hope to develop more effective treatments for depressed children and teens in the future.

depression is a debilitating illness affecting large numbers of young people. psychotherapy approaches have shown some promise in teens, but few studies have examined these interventions when offered in a group format. the role of parents in treatment outcome has also received little attention. in this study, children and adolescents ages 10 to 17 meeting criteria for clinical depression will participate in a 15-session group therapy (cognitive behavioral therapy or cbt) that teaches strategies for overcoming depressed mood. for half the participants, their parents will also participate in a parent group to help them better manage their depressed children and teens. we will randomly assign children to cbt with or without parental involvement. we hope to show that involving parents results in additional improvements in the children. we will also study factors that predict which children do best in treatment, and maintenance of gains at 6 month and 1 year follow-up. these findings will allow us to provide more effective treatments to depressed children and teens in the future.

Eligibility criteria:
inclusion criteria: * children and adolescents meeting dsm-iv criteria for either major depression or dysthymic disorder. exclusion criteria: * psychotic, * actively suicidal, * iq less than 80, * unable to speak english

Keywords: cognitive behavioral therapy depression group therapy parenting children and adolescents
the effect of menthol ice and frozen saline applications after lumbar disc surgery

Conditions: Thirst; Sore Throat

Summary: the aim of the study was to determine the effect of postoperative menthol ice and frozen saline applications on thirst and sore throat in patients undergoing lumbar disc surgery.

in the postoperative period, patients become susceptible to many complications that may develop due to general anaesthesia, endotracheal intubation, surgical intervention and clinical conditions. one of the conditions that patients experience quite intensely in the postoperative period and which is usually ignored in clinics is the feeling of thirst. another problem that may occur in patients undergoing surgery under general anaesthesia is discomfort due to endotracheal intubation. patients may experience problems such as sore throat, hoarseness, difficulty swallowing and dry throat in the postoperative period due to endotracheal intubation. diagnosis and control of postoperative thirst and sore throat contribute to patient comfort and prevention of complications. this study is considered important because it draws attention to postoperative thirst and sore throat, a problem that surgical patients have.

Eligibility criteria:
inclusion criteria: * knowing how to read, write and speak turkish * having no obstacle in understanding and communicating the information given * agreeing to participate in the research verbally and in writing after being informed about the research * ages 18 and over * those who underwent surgery under general anesthesia * those who have not yet started oral intake in the postoperative period * without menthol allergy * according to the american society of anesthesiologists (asa) classification; class i, ii and iii, normal healthy patient (asa i); patient with mild systemic disease (asa ii); patient with serious systemic disease that does not affect daily activities (asa iii) * having no sore throat before surgery * as a result of the evaluation made with the safety protocol for management thirst in the early postoperative period , patients who provide appropriate conditions for ice application (the individual must be conscious and oriented after the surgery, the airway must be open with coughing, swallowing and breathing, and there is no nausea or vomiting) exclusion criteria: * those who have severe nausea and vomiting at the time of application * those with a change in consciousness status/acute confusion after surgical intervention * those with chronic disease/diseases related to ear-nose-throat diseases * patients with difficult intubate * patients with psychiatric problems

Keywords: lumbar disc disease thirst menthol ice
the effect of reading book on preoperative anxiety

Conditions: Preoperative Anxiety

Summary: observe the effects of reading an informative story book on preoperative anxiety and maternal anxiety

observe the effects of reading an informative story book at preoperative period on preoperative anxiety by m-ypas in the holding area and on maternal anxiety by stai in the holding area.

Eligibility criteria:
inclusion criteria: * asa 1-2 * elective surgery exclusion criteria: * chronic diseases * development disability * prematurity * neurological diseases * psychoactive medication use * hearing/visual impairment * history of surgery