Kornimate/medical-research-clean huggingface dataset:
comparison of postoperative analgesia methods in elective cesarean section surgeries

Conditions: Opioid Use; Postoperative Pain

Summary: since many intravenous anesthetic agents administered to the mother can cross the placental barrier and cause fetal side effects, multimodal analgesia strategies with peripheral nerve blocks are preffered with greater safety in elective cesarean section surgeries. the primary objective of this study is to compare postoperative opioid consumption and pain scores (nrs) in elective cesarean section patients who receive a transversalis fascia plane block versus those who receive surgical site local anesthetic infiltration in addition to spinal anesthesia.

after cesarean sections, several factors play a role in the formation of postoperative pain, including parietal stimulation originating from the surgical incision, visceral stimulation originating from the peritoneum, and manipulation of intra-abdominal structures. to enhance patients' rehabilitation during the postoperative period, promote lactation and infant care, and reduce hospital stays, the most appropriate postoperative analgesia method should be selected. since many intravenous anesthetic agents administered to the mother can cross the placental barrier and cause fetal side effects, regional anesthesia techniques are preferred with greater safety in elective cesarean section surgeries. in the postoperative period, multimodal analgesia strategies can be used for pain control, and one of these strategies is postoperative peripheral nerve blocks. ultrasound guided transversalis fascia plane block is one of the preferred methods for postoperative analgesia in cesarean section patients. the primary objective of this study is to compare postoperative opioid consumption and pain scores (nrs) in elective cesarean section patients who receive a transversalis plane block versus those who receive surgical site local anesthetic infiltration in addition to spinal anesthesia.

Eligibility criteria:
inclusion criteria: * patients over 18 years old * asa ii-iii patients undergoing elective cesarean section exclusion criteria: * asa iv patients * patients with known neurologic or psychiatric disorders * patients with clinically significant cardiovascular, respiratory, hepatic, renal or metabolic disease * patients with alcohol or drug addiction * mentally disabled patients * patients with bmi\>30 * patients who develop massive bleeding or coagulopathy

Keywords: opioid use postoperative pain transversalis plane block
effect of high intensity electromagnetic body shaping on profile of metabolism in obese men

Conditions: Central Obesity

Summary: high intensity focused electromagnetic technology's secondary effects are observed in the fat (adipose). within 8 h of a treatment session, apoptotic levels in adipose increased 91.7%.8 in addition, after the application of the high intensity electromagnetic technique, there is an increase in the rapid release of free fatty acids, so it can be used in weight loss

sixty obese males will be grouped to: first group (30 males) and second group (30 males). first and second groups will undergo dietary caloric restriction (i.e low calorie diet) and will be instructed to walk 10,000 continuous steps every day using the pedometer application for 3 months. only the first group will will undergo high intensity electromagnetic technique on abdomen of males which will be 3 sessions per week for 3 months

Eligibility criteria:
inclusion criteria: * men with central obesity * bmi 30-34.9 kg/m2 exclusion criteria: * metabolic /cardiovascular, pulmonary illnesses, musculoskeletal/neurological illness, autoimmune/psychological illnesses
snap vs bis(oaa/s) scale during a sedation regimen with and without ketamine

Conditions: Pain

Summary: the study question: does the snap-index (si) correlates better with the oass than the bis monitor during sedation with ketamine? the study hypothesis: since the snap ii monitor seems to be more responsive during emergence of anesthesia, it will have a better correlation with the oass than the bis monitor with the use of ketamine.


Eligibility criteria:
inclusion criteria: * age : 18-64 years * asa : i-iii * procedure : breast or gynecological surgery * anesthesia :monitored anesthesia care exclusion criteria: * pregnancy * breast feeding * body mass index \>35kg/m2 * drug or alcohol abuse * use anticonvulsants * history of cva * drop-out criteria: * patient or surgeon request * conversion to general anesthesia * inability to obtain data from both monitors

Keywords: bispectral index ketamine
comparison of imaging characteristics of uexplorer and conventional pet/ct in patients with lung cancer, lymphoma, and melanoma

Conditions: Lung Neoplasm; Lymphoma; Melanoma; Fluorodeoxyglucose; Positron-emission Tomography

Summary: to determine the minimum scan duration for fluorine-18 positron-emitting radioactive isotope-fluorodeoxyglucose (18f-fdg) positron emission tomography (pet)/computed tomography (ct) scans performed on a total-body pet/ct scanner that results in non-inferior image quality to 18f-fdg pet/ct scans performed on a conventional pet/ct scanner. the subject population will be patients being staged for lung cancer, lymphoma, or melanoma.


Eligibility criteria:
inclusion criteria: 1. ability to understand and willingness to sign an informed consent form. 2. ability to adhere to the study visit schedule and all protocol requirements. 3. men and women ≥18 years of age. 4. diagnosis or suspected diagnosis of lung cancer, melanoma or lymphoma. 5. patients who have been referred for a pet/ct scan. exclusion criteria: 1. pregnant women. 2. claustrophobia. 3. any significant medical condition that in the opinion of the investigator would prevent the subject from participating and/or adhering to study related procedures or interfere with subject safety.
expanded access use of itacitinib to treat a single patient with aplastic anemia

Conditions: Aplastic Anemia

Summary: expanded access use of itacitinib to treat a single patient with aplastic anemia


Eligibility criteria:
inclusion criteria: - exclusion criteria: -
rehabilitation programs after achilles tendon rupture

Conditions: Rupture of Achilles Tendon; Immobility Response, Tonic; Rupture, Spontaneous

Summary: the purpose of this study is to evaluate the effects of early mobilization versus traditional immobilization rehabilitation programs after surgical achilles tendon repair on the mechanical (torque-angle and torque-velocity relationships) and electrical (neuromuscular activation) properties of the plantar- and dorsiflexor muscles, gastrocnemius medialis morphology (muscle architecture), functional performance, and the mechanical and material properties (force-elongation and stress-strain relationships) of the injured and uninjured achilles tendon. the hypothesis is that the early mobilization could reduce the deleterious effects of the joint immobilization and improve the tendon healing.

participants were allocated into one of two intervention groups (traditional immobilization or early mobilization). traditional immobilization group (45 days of plaster cast immobilization; after the immobilization period, subjects received instructions on how to perform a home-based exercise program) early mobilization (six weeks of physical therapy program; three times per week; one to two hours of exercises for regaining range of motion and muscular endurance) control group (subjects had no history of lower limb injury, and were matched in age and anthropometric measurements to subjects that performed physical rehabilitation and to subjects that remained immobilized.

Eligibility criteria:
inclusion criteria: * male * achilles tendon rupture exclusion criteria: * arterial insufficiency * diabetes * autoimmune disease * patients who used systemic antibiotics or steroids or showed any other clinical contraindication to perform maximum voluntary contractions on a dynamometer.

Keywords: achilles tendon rupture rehabilitation immobilization muscle architecture functionality neuromuscular parameters weight-bearing
inflammatory mediators in early sepsis

Conditions: Inflammation

Summary: sepsis is still a challenge for clinicians since the detailed pathomechanism are still unknown and until now early markers for sepsis are not defined yet. immunological pathways and new mediators defined in animal models are not yet investigated in patients with sepsis. therefore the investigators will measure new mediators in patients with septic shock.

semaphorins 1 to 7 will be determined in blood of patients with early septic shock. concentration will be compared with blood concentration of postoperative patients suffering systemic inflammatory response syndrome (sirs).

Eligibility criteria:
inclusion criteria: * septic shock exclusion criteria: * age \ 85 * no consent of caregiver * trauma patients * burn patients * immunosuppression * pregnancy * hiv- hepatitis infection
a study of msdx complex 1 as a marker for therapy response in multiple sclerosis

Conditions: Relapsing Remitting Multiple Sclerosis

Summary: the purpose of this study is to compare biomarker levels in multiple sclerosis (ms) patients before and after beginning natalizumab.


Eligibility criteria:
inclusion criteria: 1. diagnosis of clinically definite relapsing remitting ms (rrms) 2. age 45 years and older 3. willing and able to provide written informed consent 4. patient has high disease activity. 5. patient is about to begin natalizumab (tysabri) therapy. exclusion criteria: 1. any clinically significant disease other than ms that is likely to interfere with the evaluation of cdms 2. known infectious or hematological disease. 3. unwilling or unable to comply with the requirements of this protocol 4. subject can not have a gadolinium enhanced mri

Keywords: ms rrms rr multiple sclerosis
appetite profile after intake of rye breakfast meal

Conditions: Obesity Prevention

Summary: food structure influence metabolic response including appetite. whole grain foods include a wide range of products; cracked or cut kernels, rolled flakes or milled to flour and used in foods such as breads, breakfast cereals and pasta.

the aim of the present study was to investigate if rye grain structure influence perceived appetite. a comparison of whole rye kernels and milled rye kernels were done in two study parts. in the first part the rye was served as porridge breakfasts and in the second one milled and whole kernels were included into bread breakfasts. in order to observe potential effects that would arise when the remains of the meal reaches the colon, the period of measurement was set to 8 h after intake of iso-caloric rye bread and rye porridge breakfasts. a randomized, crossover design was used to compare the effects of iso-caloric breakfast meals on subjective appetite during 8 h after consumption.

Eligibility criteria:
inclusion criteria: * 20 and 60 years; * body mass index (bmi) 18-27 kg/m2; * habit of consuming breakfast, lunch and dinner every day * willingness to comply with the study procedures exclusion criteria: * intake of medicine likely to affect appetite or food intake; * any medical condition involving the gastrointestinal tract; * eating disorder; * smoking; * consumption of more than three cups of coffee per day; * change of body weight more than 10% three months prior to screening; * consumption of any restricted diet such as vegan, gluten free, slimming etc.; * pregnancy, lactation or wish to become pregnant during the study period

Keywords: satiety grain structure rye
the efficacy and safety of curcuma domestica extracts and ibuprofen in knee osteoarthritis

Conditions: Osteoarthritis

Summary: osteoarthritis of knee is common degenerative musculoskeletal diseases. non-steroidal antiinflammatory drugs (nsaids) are used to decrease pain symptom but someone can not tolerate its gastrointestinal adverse effects. in vitro studies showed that curcumin had an inhibitory effect on substances playing an important role in inflammatory pathway. the mechanisms by which curcumin prevents inflammation are postulated through inhibition of many cytokines, for example, lipo-oxygenase, cyclo-oxygenase, and phospholipase. therefore, if curcumin is effective as nsaids with less side effects, it can be an alternative treatment for those oa knee patients.

curcumin was demonstrated to be safe and had anti-inflammatory activity in six studies in humans. it may exert its anti-inflammatory activity by inhibition of a number of different molecules that play a role in inflammation. our experience in a study of 100 subjects revealed a trend towards a greater effect in oa patients receiving curcuma domestica extracts. however, studies with adequate sample and dosage of ibuprofen are recommended to demonstrate the efficacy of c.domestica extracts in alleviating knee pain and improving knee functions. the objective of the study was to determine the efficacy and safety of c.domestica extracts in pain reduction and functional improvement in patients with knee osteoarthritis.

Eligibility criteria:
inclusion criteria: * primary osteoarthritis * knee pain score more than or equal to 5 point (nrs 0-10) * age \>= 50 years, not \> 75 years * knee crepitus * knee stiffness less than 30 minutes * urine pregnancy test negative in case of not being menopausal period exclusion criteria: * history of gi ulcer or melena * having hepatic or bile duct diseases(sgot ≥ 37 u/l, sgpt ≥ 40 u/l) * having renal disease or abnormal renal functions (serum creatinine ≥ 1.5 mg/dl) * asthma or gout * allergy to ibuprofen or curcumin * history of intraarticular knee injection within 6 months * post knee arthroplasty * history of intermittent claudication * unable to walk, for example hemiplegia, severe lung/heart diseases * knee x-ray found chondrocalcinosis * on anticoagulant

Keywords: osteoarthritis, knee, curcumin, multicenter, rct
internal fixation of hip fractures using intraoperative simultaneous two axis view

Conditions: Fracture Neck of Femur

Summary: hip fractures are one of the most frequent operated fractures procedures in orthopedics, with a world wide annual incidence of approximately 1.7 million. these fractures are associated with substantial morbidity and mortality. as populations age and life expectancy increases worldwide, the incidence of these fractures is likely to raise, expected to triple in the next 50 years. the use of fluoroscopy and resultant exposure to radiation, is an integral part of surgical procedures aiming to reduce and fixate the fractured femur. the risk of contracting cancer is significantly higher for an orthopedic surgeon as hip surgery is a major slice of the total radiation dose. optimal positioning and control of the imaging intensifier device may result in significant reduction of radiation dose and time and in substantial shortening of the procedure. the investigators hypothesis is that this technique would substantially shorten procedure time and reduce unnecessary radiation exposure for both the patient and the medical staff. furthermore, by using this technique the investigators can eliminate the need for fluoroscopy technician during the surgery, as there is no need to alternate fluoroscopy views.


Eligibility criteria:
inclusion criteria: * patients with intertrochanteric femoral fracture who are going to be operated by closed reduction and internal fixation with an intramedullary nail.

Keywords: radiation time surgery
prevention of neutropenia after using g-csf with tac chemotherapy

Conditions: Neutropenia

Summary: after resection of lymph node positive breast cancer, the injection duration and timing of granulocyte-colony stimulating factor (g-csf) could affect the neutropenia with tac (taxotere, adriamycin, cyclophosphamide) chemotherapy.

the duration and the injection timing of g-csf are effective in the prevention of neutropenia, incidence of infection and non hematologic toxicity. with the tac chemotherapy after resection of breast cancer, the g-csf early injection versus late injection could change the frequency of neutropenia.

Eligibility criteria:
inclusion criteria: * primary invasive breast carcinoma with lymph node positive with curative surgery with tac chemotherapy exclusion criteria: * pregnancy, * cardiovascualr disease, * abnormal renal function, * hematologic disorder

Keywords: g-csf neutropenia tac
a study of ac-201 controlled-release tablet (cr tablet) in patients with gout

Conditions: Gout

Summary: the study is designed to test the urate-lowering effect, safety, and tolerability of ac-201cr in an initial dosing period, followed by the addition of a ult to test the efficacy and safety of the combination and prophylaxis of gout flares during ult.

ac-201cr is a control released formulation of ac-201 that in previous clinical studies showed potential dual effects in both reducing serum uric acid (sua) and gout flares. the mechanism of action of ac-201 includes the inhibition of the production and activity of caspase-1 and interleukin-1β (il-1β), and selective inhibition of re-absorption transporters in the kidney. the goal of gout treatment is to reduce serum uric acid (sua) concentrations below the urate solubility limit while avoiding acute gout flares. however, the initiation of urate-lowering therapy (ult) increases the occurrence of acute gouty arthritis flares. il-1β plays a key role in mediating this inflammatory response.

Eligibility criteria:
inclusion criteria: 1. male or female age 20 to 65 years, inclusive. 2. meets ≥6 of the 12 american college of rheumatology preliminary criteria (1977) for the classification of acute arthritis of primary gout (appendix 2), or have proven tophus or documented monosodium urate (msu) crystals in the joint fluid. 3. serum uric acid ≥7.5 mg/dl and ≤10 mg/dl at screening with ≥1 gouty arthritis flare within one year prior to screening, or serum uric acid ≥9 mg/dl and ≤10 mg/dl at screening with or without prior gout flares. exclusion criteria: 1. use of allopurinol, febuxostat, benzbromarone, probenecid, or sulfinpyrazone within 2 weeks prior to screening. 2. occurrence of a gouty arthritis flare within 1 week prior to screening or during the screening period through baseline. 3. use of colchicine within 1 week prior to screening. 4. use of glucocorticoids, nsaids or cox-2 inhibitors within 1 week prior to screening. 5. allergy, contraindication, or intolerance to febuxostat. 6. severe renal impairment. 7. aspartate aminotransferase (ast) or alanine aminotransferase (alt) concentration \>2 times the upper limit of laboratory normal range (\>2x uln) at screening.
the effect of pregnancy on the pharmacokinetics of the kaletra tablet

Conditions: Pregnancy; HIV

Summary: in this study, we are looking at blood concentrations of kaletra in hiv positive patients during pregnancy. the patients will come in for 4 visits lasting \~24hrs. these visits take place at 20-24 weeks, 30 weeks, 32 weeks and 8 weeks post-partum. at the end of vist 2 (week 30), we will increase your dose to 2 adult kaletra tablets, and one pediatric kaletra tablet (total dose 500/125mg). the dose will remain increased until you are 2 weeks post partum, then it will return to the standard 2 adult tablets (400/100mg).


Eligibility criteria:
inclusion criteria: * hiv positive * pregnant (\<22 weeks) * currently taking or planning to start kaletra * ≥18 years of age exclusion criteria: * active opportunistic or serious bacterial infection at the time of entry * past or present obstetrical complications (including, but not limited to: placentia previa, eclampsia, confirmed birth defects, multiple gestation pregnancies) * unable to maintain medication adherence, defined as ≥ 80% of doses taken between visits * currently receiving or expected to receive other protease inhibitors in conjunction with kaletra® * hiv genotype showing accumulation of protease inhibitor mutations expected to result in virologic failure on kaletra® or documented virologic failure on kaletra®-containing regimen attributable to the kaletra® component * chronic hepatitis b and/or c virus infection * cushing's syndrome * untreated hypothyroidism or hyperthyroidism * serum creatinine \> 1.5 mg/dl * amylase 1.5 times uln and/or abnormal lipase * direct or total bilirubin levels \> grade 1 * alt/ast \> grade 2 (based on the nih division of aids (daids) table for grading the severity of adverse events * bicarbonate \> grade 2 (daids) * hematology \> grade 2 (daids), except for anemia: exclude only women with hb\< 9 g/dl and/or hct , 27.3% (\< 8.5 mg/dl and/or hct , 25.6% if currently on zdv) at screening; all subjects with anemia who enroll in the study must be receiving or start hematinics, including iron and folate supplements, immediately upon enrollment and continue until anemia resolves or end of pregnancy. the hematinic supplements may be discontinued at the discretion of the investigator if they consider continuation would not be in the best interest of the subject. * receiving the following drugs: astemizole, terfenadine, rifampin, cisapride, ergot derivatives, simvastatin, lovastatin, st. john's wort, pimozide, midazolam, triazolam, carbamezapine, phenobarbital, phenytoin, or dexamethasone
effects of cognitive fatigue on heart rate variability and skin conductance

Conditions: Cognitive Fatigue; Mental Fatigue; Behavioral Performance; Heart Rate Variability; Skin Conductance

Summary: this study aims to examine the effects of cognitive fatigue on heart rate variability and skin conductance and develop a machine learning model.

we hypothesize that increased cognitive fatigue would vary as a function of heart rate variability and skin conductance. a machine learning model will be developed that predicts cognitive fatigue through these physiological responses (lee et al., 2021). individual differences (i.e., age, gender, caffeine and food intake, body mass index, skin temperature, sleep quality, baseline physiology and behavioural performance) will be examined and accounted for.

Eligibility criteria:
inclusion criteria: * singapore-based * non-clinical * 18-35years exclusion criteria: * individuals with hearing difficulties or failing to meet the minimal threshold for normal hearing * individuals with a history of ear, developmental, neurological, or psychiatric disorder