Kornimate/medical-research-clean huggingface dataset:
epidemiology of blood pressure, insulin, salt transport

Conditions: Cardiovascular Diseases; Heart Diseases; Hypertension; Obesity

Summary: to determine the roles of insulin, lipids, body weight and ion transport in blood pressure regulation.

background: insulin levels are consistently related to blood pressure, obesity, and blood lipids. insulin level correlation with sodium-lithium countertransport is limited to only one available study done in white, normotensive, predominantly normal weight women aged 45-52. the relationship between cellular sodium-hydrogen exchange activity and hypertension has been studied in rats and in a small study in humans. correlation of this transport with weight, fasting insulin and lipid levels, and sodium-lithium countertransport was not available in 1989. design narrative: the study was cross-sectional. subjects were stratified by weight: plus or minus 10 percent of desirable weight; 11 to 30 percent over desirable weight; and 30 percent over desirable weight; and by diastolic blood pressure: 80; 80-89; 90-99 mmhg. blood pressure, height, weight, waist and hip girth, skinfold, fasting and post-glucose load insulin, glucose, lipids, creatinine, maximal rates of red blood cell sodium-lithium countertransport and platelet sodium-hydrogen exchange, ph, and calcium concentrations were measured. the strength and independence among these continuous variables were measured by pearson correlations, partial correlations, and multiple regressions within each stratum, and if appropriate, over all strata. the study examined the hypotheses that: part of the relationship between obesity and blood pressure was due to insulin effects and/or lipid effects on ion transport; the relationship between ion transport and blood pressure was related to an abnormality of sodium-hydrogen exchange, for which the observed increase in sodium-lithium countertransport was a marker; increased blood pressure was related to the alteration of intracellular ph and/or calcium concentration. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria
post-marketing clinical follow-up of a spine implant

Conditions: Lumbar Disc Herniation; Annular Tear of Lumbar Disc

Summary: post-marketing clinical follow-up of an anular closure system (barricaid®) to confirm comparability of outcome between devices with subcomponents from two different suppliers

comparison of device integrity (anchor fracture and/or mesh detachment) and device movement/migration in patients implanted with the barricaids with anchors from two different suppliers.

Eligibility criteria:
inclusion criteria: * each site will enroll all patients who were implanted with a barricaid with an anchor manufactured by the second manufacturer. * patients must be 18 years of age or older and able to understand and consent to participate in the study. exclusion criteria: * not defined
fatigue in breast cancer patients undergoing radiotherapy-esmart-mh

Conditions: Breast Cancer

Summary: the purpose of this study is to determine if an avatar-based depression self-management intervention (esmart-mh) once a week for the duration of the participant's radiation treatment will significantly reduce depressive symptoms. investigators also seek to explore how women with breast cancer describe their mood using prompted and unprompted speech through electronic social media and interviews. participants will be randomized into the esmart-mh group or the theater testing (attention control) group. in addition to the assigned interventions, participants will be asked to complete questionnaires and interviews with the study staff.

the purpose of this study is to determine if an avatar-based depression self-management intervention (esmart-mh) once a week for the duration of the participant's radiation treatment will significantly reduce depressive symptoms. investigators also seek to explore how women with breast cancer describe their mood using prompted and unprompted speech through electronic social media and interviews. participants will be randomized into the esmart-mh group or the theater testing (attention control) group. in addition to the assigned interventions, participants will be asked to complete questionnaires and interviews with the study staff. participants will be enrolled within two weeks of radiotherapy. a preliminary depression survey (ids-sr) will be given to assess depression. there will be a total of three routine study assessments, one within two weeks prior to the beginning of radiotherapy, one the last week of radiotherapy and one 5 - 7 weeks after radiotherapy is completed.

Eligibility criteria:
inclusion criteria: * patients seen in the emory breast center at the emory clinic and emory midtown hospital who are treated with curative intent. * score of 8 or higher on the inventory of depressive symptomology - self reported (ids-sr) test

Keywords: radiation therapy
measuring patient-reported adverse events in oncology practice improves quality of life in nasopharyngeal carcinoma

Conditions: Nasopharyngeal Neoplasms

Summary: although patient-reported adverse events have been promoted as an essential element in clinical trials and daily managements, their efficacy remained unknown. the purpose of this trial was to determine the effect of the patient-reported adverse events during the treatment on the improvements on quality of life.


Eligibility criteria:
inclusion criteria: * patients with newly histologically confirmed non-keratinizing carcinoma (according to who histological type) * no evidence of distant metastasis (m0) * performance status: ps 0\~2 * receive standard treatment * able to read and understand the questionnaires * not exhibiting overt psychopathology * willing to give feedback to physicians and written informed consent was obtained exclusion criteria: * who type keratinizing squamous cell carcinoma or basaloid squamous cell carcinoma. * treatment with palliative intent. * prior malignancy (except adequately treated carcinoma in-situ of the cervix or basal/squamous cell carcinoma of the skin) * previous chemotherapy or radiotherapy (except non-melanomatous skin cancers outside the intended rt treatment volume) * patient is pregnant or lactating * severe intercurrent disease
postoperative recovery in elderly patients undergoing hip hemi-arthroplasty

Conditions: Femoral Neck Fractures; Postoperative Complications; Inflammatory Response; Postoperative Delirium; Postoperative Cognitive Dysfunction

Summary: hip fractures incidence grows rapidly with the aging of the population. after indicated surgical treatment, hip fracture patients experience high rates of postoperative complications, postoperative delirium (pd), postoperative cognitive dysfunction (pocd), leading to poor postoperative recovery during hospitalization, which can cause disability, distress for both patients and their families, are associated with other medical complications and account for significant additional health care costs. we currently use dexmedetomidine in elderly patients with hip fractures undergoing hip hemi-arthroplasty in order to improve postoperative recovery and prevent and treating pd and pocd. dexmedetomidine is a drug used for sedation in critically ill patients that provides some pain relief and controls the bodies response to stress. the sedation produced by dexmedetomidine appears more similar to natural sleep than any other drug used for anesthesia and postoperative sedation. data suggesting that dexmedetomidine can prevent delirium following cardiac surgery and the developing understanding of the causes of pd and pocd suggest that dexmedetomidine will be particularly effective.


Eligibility criteria:
inclusion criteria * age \> 75years old * patients with femoral neck fractures * undergoing hip hemi-arthroplasty surgery * american society of anesthesiologists (asa) physical status ii-iv * moca being more than 23 exclusion criteria * patient refusal to participate in the study * patient refusal or failure of regional block * allergic to local anesthetics or general anesthetics * history of opioid dependence * contraindications to nerve blocks (coagulation defects, infection at puncture site, preexisting neurological deficits in the lower extremities) * current severe psychiatric disease or alcoholism or drug dependence * severe visual or auditory disorder
strongest predictors of a positive outcome after physiotherapy for knee osteoarthritis

Conditions: Osteoarthritis, Knee

Summary: individuals with painful knee osteoarthritis (oa) experience restricted physical function. few previous studies have investigated comprehensive sets of constructs and tests to investigate physical function in these patients. most single studies of knee oa patients show limited scope for explaining physical function in the perspective of who's international classification of functioning, disability and health (icf) 3 levels: body functions (the bodily level), activities (individual level), and participation (societal level). on the bodily level there is limited case-control knowledge on muscle strength beyond the knee and endurance-strength in general. on the activity level, there is similar limitation of biomechanical bodily features in stair climbing. on the participation level the situation is similar for objective performance. measures are needed that inter-relate all three levels of icf. these should also include well discriminating tests e.g. knee strength, walking, and activities of daily life (adl), as well as both objective and subjective measures. the purpose of this study is to explore mechanisms that can explain physical function in patients with knee oa in primary care. the study's main and primary goal is to quantify which baseline factors and change scores are the strongest predictors of a positive treatment outcome in terms of patients' global perceived change after physiotherapy. secondary research question is: which factors are the strongest predictors of a positive outcome of physiotherapy in knee oa, in terms of pain intensity, patient specific functional scale, and function in daily living?


Eligibility criteria:
inclusion criteria: 1. clinical and radiological osteoarthritis of the knee and referred to physiotherapists. 2. symptomatic daily during the last month. 3. symptomatic for more than one year. 4. able to walk up and down a flight of 10 stairs with or without walking aids. 5. able to walk 3 stairs up and down without walking aids. 6. understand norwegian orally and in writing. 7. body mass index below 35. exclusion criteria: 1. neurological, rheumatic, orthopedic, or respiratory diagnosis, other than osteoarthritis of the knee which can negatively affect the walking ability, balance or pain. 2. body mass index above or equal to 35. 3. fracture of the femur or shank, or arthroscopic surgery in the osteoarthritic knee. 4. chronic generalized pain (american college of rheumatology criteria, 2010). 5. inability to understand norwegian language.

Keywords: physical therapy modalities recovery of function predictive value of tests cohort studies
retrospective multicenter clinical evaluation of complications for single or multilevel veo® lateral access and interbody fusion system and extreme lateral interbody fusion (xlif®) subjects

Conditions: Degenerative Disc Disease

Summary: the purpose of this retrospective clinical evaluation is to compare veo® single or multilevel results to xlif® single or multilevel results relative to the safety endpoints. this study will collect retrospective data on subjects who were treated with veo® and xlif® at least 3 months prior to the initiation of this study. given that fusion generally takes at least 6 months to determine, the aim of this study is not to determine fusion but to consider the short-term (out to 6 months) reported adverse events between the two cohorts. devices used in both systems are cleared for use and conform to us regulatory requirements. the study employs these procedures and devices for uses that are consistent with their 510(k), legally cleared, labeling.


Eligibility criteria:
inclusion criteria: * adult 18 years of age or older; * male or female veo® subjects that had previously received the single or two level llif procedure using the veo® or xlif® systems as an adjunct to fusion at l2-s1 to treat degenerative disc disease (ddd) at the treated level; * subject that was treated no less than 3 months prior to this evaluation with the llif procedure using the veo® or xlif® system by the participating surgeons. exclusion criteria: * subject who did not receive llif procedure using the veo® or xlif® system for fusion of l2-s1; * subjects with less than 3 months of follow-up data.
increased dietary protein and meal frequency reduces total and abdominal body fat during weight maintenance and weight loss

Conditions: Obesity

Summary: the purpose of the current study was to examine the impact of macronutrient intake (pro, 15% vs. 35%) and meal frequency (3 vs. 6 meals/day) on body composition, postprandial thermogenesis and plasma adipokines before and after 28days each of eb (28days) and ed (25%; 28days) in overweight individuals. we hypothesize that hp will elicit more favorable body composition, thermogenic, and cardiometabolic changes than hc intakes and the magnitude of change will be greatest in those consuming hp meals more frequently.


Eligibility criteria:
inclusion criteria: * 30-65 years old, * overweight or obese but otherwise in good health exclusion criteria: * cardiovascular disease, * cancer, * htn, * type i or ii dm, * food allergies

Keywords: high protein high carbohydrate meal frequency abdominal body fat postprandial thermogenesis
telemedicine evaluation of dry eye disease using a portable automatic ocular surface imaging device (paosid)

Conditions: Dry Eye Disease (DED)

Summary: this study aims to evaluate the diagnostic accuracy and grading consistency of a mobile phone-attached portable automatic ocular surface imaging device (paosid) for assessing dry eye disease (ded). both patients diagnosed with ded and healthy volunteers will undergo conventional clinical imaging, including white-light anterior segment photography, corneal fluorescein staining (cfs) under cobalt blue light, and tear film break-up time (tbut), all performed under slit-lamp examination, as well as meibography. clinical grading of ded severity will follow the tfos dews i criteria, while other ocular surface findings-such as conjunctival injection, meibomian gland area loss, and cfs-will be assessed using standard ocular surface disease scoring scales. following the clinical assessment, participants will use the paosid device to independently capture similar ocular surface images and videos. these remote images and videos will first be used to determine whether the participant has dry eye disease (ded). regardless of the diagnosis result, all participants will undergo severity grading based on the tfos dews i criteria, along with standardized scoring of ocular surface conditions such as conjunctival injection, meibomian gland area loss, and corneal fluorescein staining (cfs). the study will compare remote and clinical assessments to evaluate diagnostic agreement and grading consistency, and assess patient satisfaction and usability of the paosid system.

multicenter, cross-sectional

Eligibility criteria:
inclusion criteria: 1. participants included individuals with dry eye, based on the tfos dews ii (the tear film and ocular surface society dry eye workshop ii) guidelines,(19) as well as relatively healthy individuals with no ocular conditions who voluntarily agreed to participate in the study. 2. participants, or their companions or caregivers, who are willing and able to use the study smartphone to capture relevant eye images and videos. 3. aged 18 years or older. 4. provide informed consent. exclusion criteria: 1. participants with ocular surface disorders other than ded that may affect the appearance of the ocular surface (e.g., pterygium, keratitis, corneal scarring) or with any organic pathologies impacting vision (e.g., cataracts, glaucoma, retinal diseases). 2. patients currently wearing scleral lenses or bandage contact lenses. 3. unable to cooperate with the paosid, such as due to a serious mental illness or brain damage causing loss of limb control. 4. significant changes in the ocular images since diagnosis due to factors such as postdiagnostic treatment. eye selection criteria
study of antibody responses after a dose of tetravalent meningococcal diphtheria conjugate vaccine in children

Conditions: Meningitis; Meningococcemia

Summary: the study investigated safety profile and the antibody responses to an experimental tetravalent meningococcal diphtheria conjugate vaccine (menactra®) in children who have received a monovalent meningococcal c conjugate vaccine at least one year previously. primary objective: to describe and compare the serum bactericidal assay (sba) antibody response for serogroup c in participants receiving menactra® to the serogroup c antibody response in a control group of participants receiving a licensed haemophilus influenzae type b (hib) conjugate vaccine 28 days following vaccination.


Eligibility criteria:
inclusion criteria : * participant is healthy, as determined by medical history and physical examination. * participant is 2 years to \< 5 years of age at the time of vaccination. * at least one year from primary vaccination with a monovalent meningococcal c conjugate vaccine has elapsed. * parent/guardian has signed an ethics committee-approved informed consent form. a culturally appropriate translation will be used for non-english speaking participants where required. exclusion criteria : * serious chronic disease (i.e. cardiac, renal, neurologic, metabolic, rheumatologic, etc.) * known or suspected impairment of immunologic function * acute medical illness with or without fever within the last 72 hours or an axillary temperature ≥ 37.5ºc at the time of inclusion * history of documented invasive meningococcal disease * administration of immune globulin, other blood products within the last three months, injected or oral corticosteroids or other immunomodulatory therapy within six weeks of the study vaccine. individuals on a tapering dose schedule of oral steroids lasting \< 7 days may be included in the trial as long as they have not received more than one course within the last two weeks prior to enrolment * antibiotic therapy within the 72 hours prior to vaccination or 72 hours prior to drawing any blood sample * received any vaccine in the 28-day period prior to enrolment, or scheduled to receive any vaccine during enrolment in the trial * received a meningococcal c conjugate vaccine within one year prior to enrolment * suspected or known hypersensitivity to any of the vaccine components * unavailable for the entire study period or unable to attend the scheduled visits or to comply with the study procedures * enrolled in another clinical trial * any condition, which, in the opinion of the investigator, would pose a health risk to the participant or interfere with the evaluation of the vaccine.

Keywords: meningitis meningococcemia neisseria meningitidis
women's use of alternative medicine: a multiethnic study

Conditions: Uterine Fibroids; Osteoporosis; Urinary Tract Infection; High Blood Pressure; Heart Disease; Arthritis; Depression; Headaches

Summary: the purpose of this study is to examine socio-cultural factors of women's use of complementary and alternative medicine (cam). the effects of socioeconomic status, social networks and acculturation on cam use will be assessed among white, african-, mexican-, and chinese-american women.


Eligibility criteria:
inclusion criteria: experienced one or more of the following health conditions within the last year: * pregnancy related symptoms * menopausal related symptoms * headaches * back pain * osteoporosis * cancer * high blood pressure * high cholesterol * heart disease * joint pain/arthritis * insomnia * uterine fibroids * urinary tract infection * vaginal tract infection * medically diagnosed depression * menstrual symptoms

Keywords: race ethnicity complementary and alternative medicine women's health social determinants of health
non alcoholic fatty liver disease influence of statin therapy

Conditions: Non-alcoholic Fatty Liver Disease (NAFLD)

Summary: aim: 1. to determine the prevalence of fatty liver in a cohort of patients hospitalized with chest pain in the cardiology department. 2. to assess the effect of statins on the prevalence of fatty liver by a cross sectional survey of patients hospitalized with chest pain.

consecutive patients hospitalized with chest pain will be recruited at the cardiology department. patients with an inflammatory condition, recent infection or history of alcoholism will be excluded. after signing an informed consent each patient will undergo an ultrasound examination for diagnosis of fatty liver. information regarding bmi, hypertension and use of medications will be collected on each patient. blood samples for fasting glucose, hemoglobin a1c, lipid profile, esr, and crp and liver function tests will be collected from each participant. prevalence of fatty liver in patients who have been taking statins for 6 months or more statins will be compared to patients who have been taking statins for a lesser period and to those who do have not taken statins using a multivariate regression analysis. serum samples will be frozen and kept for future ongoing research.

Eligibility criteria:
inclusion criteria: * cardiology patient * age above 18 exclusion criteria: * age below 18

Keywords: fatty liver statin non-alcoholic