Kornimate/medical-research-clean huggingface dataset:
probing the cannabinoid system in individuals with a family history of psychosis

Conditions: Psychosis; Cannabis Use; THC; Marijuana; Schizophrenia

Summary: the overall purpose of this study is to determine whether a family history of psychosis is associated with an altered cannabinoid system. this will be tested by studying individuals with and without a family history of psychosis and comparing their responses to delta 9-tetrahydrocannabinol (thc), a probe of the cannabinoid system. we hypothesize, that compared to controls with no family history of psychoses, individuals with a family history of psychoses will have an altered response to thc.


Eligibility criteria:
inclusion criteria fhp: * exposure to cannabis at least once in their lifetime * medically and psychiatrically healthy based on screening * having one relative with a confirmed psychotic disorder exclusion criteria fhp: * current or lifetime major dsm-iv axis i disorder * current or lifetime treatment (at least 6 months) with psychotropic medications for major psychiatric or neurological illness * major or unstable medical illness that might impact safety of the subject in the study * cannabis naive * iq less than 85 * less than a high school diploma or its educational equivalent * pregnancy or lactation * major current or recent (\<6 weeks) psychosocial stressors. inclusion criteria fhn : * exposure to cannabis at least once in their lifetime * medically and psychiatrically healthy based on screening exclusion criteria fhn: * having a family member with psychosis * current or lifetime major dsm-iv axis i disorder * current or lifetime treatment (at least 6 months) with psychotropic medications for major psychiatric or neurological illness * major or unstable medical illness that might impact safety of the subject in the study * cannabis naive * iq less than 85 * less than a high school diploma or its educational equivalent * pregnancy or lactation * major current or recent (\<6 weeks) psychosocial stressors.
mechanism(s) of airflow limitation during exacerbation of asthma

Conditions: Asthma

Summary: the purpose of this study is to evaluate the site and mechanisms responsible for expiratory airflow limitation in chronic, treated, non-smoking, stable asthmatics with moderate to severe persistent expiratory airflow obstruction. treatment will include inhaled corticosteroids and long acting beta2agonists. the investigators are interested in determining whether the large and/or small airways are the predominant site of airflow limitation. the investigators are also interested in determining whether intrinsic small airways obstruction and/or loss of lung elastic recoil is responsible for expiratory airflow limitation. the investigators are also interested to evaluate the role of varying doses of inhaled corticosteroids to suppress large and small airway inflammation using exhaled nitric oxide as surrogate markers of inflammation. for comparison purposes, spirometry and measurements of exhaled nitric oxide will also be obtained if possible during a naturally occurring exacerbation of asthma.

in addition we will also obtain above studies in asthmatics during naturally occuring exacerbation of asthma and following treatment. if available, results of lung function studies including measurements of lung elastic recoil will be compared to pathologic analyses of formalin fixed, air inflated lungs obtained at autopsy in asthmatics who die from asthma related or non-asthma related death. this kind of lung structure-function study will provide potential mechanism(s) to explain the loss of lung elastic recoil in acute and chronic asthmatics who are non-smokers. we will also obtain voxel quantification of high resolution thin section ct of lung obtained without iv contrast. also, we will use fiberoptic bronchoscopy to obtain optical coherence tomography in stable asthmatics with mild to moderate to severe expiratory airflow limitation to assess integrity of the lung parenchyma.

Eligibility criteria:
inclusion criteria: * current non-smoking (\<10 pack yr smoking history) * stable, treated asthmatics * age 10-80 yr * post 180ug albuterol by mdi: fev 1/fvc \< 70% and fev 1 \<80% predicted exclusion criteria: * pregnancy

Keywords: asthma lung function inflammation
laser therapy on neck pain in adolescents

Conditions: Neck Pain

Summary: the aim of the proposed study is to investigate the effects of low-level laser therapy on neck pain.


Eligibility criteria:
inclusion criteria: * age 14 to 20 years; * chronic neck pain; * no use of corticoids for at least 15 days prior to the onset of treatment; * agreement to participate; and * signed statement of informed consent by legal guardian. exclusion criteria: * currently undergoing physical therapy; * inability to participate in sessions; * specific diagnosis of infection, osteoporosis, polyarthritis or rheumatic disease; and * constant use of corticoids or analgesics.

Keywords: neck pain hydrocortisone stress electromyography adolescent low-level laser therapy
cardiovascular disease in patients with diabetes: the silesia diabetes-heart project

Conditions: Diabetes Mellitus

Summary: the project is an observational one which undertakes different, easy to obtain in everyday clinical practice, demographical, laboratory and clinical parameters of patients with diabetes in silesian region in poland to predict cardiovascular disease, cardiovascular events and neuropathy using machine learning approach.

the study is a prospective, observational one in which it is planned to obtain demographical, laboratory and clinical parameters of patients who are hospitalized in one the the main diabetology sites in silesia region in poland and to follow them prospectively for 10 years in order to collect information related to new cardiovascular events. telephone contact will be performed every 12 months following hospital discharge. any procedures related to the patients hospitalized in the diabetology ward will be the routine ones and the bioethics committee of medical university of silesia gave the permission for the study but waved the necessity of informed consent to be signed.moreover there will be subgroup analysis of patients recruited from the outpatient diabetology clinics in silesia region in order to participate in the observational study collecting data related to to vitamin d concentration, densitometry, fibroscan, carotid ultrasound examination, vascular stiffness, electrocardiography, peripheral and cardiovascular autonomic neuropathy and fundus imaging. patients who are treated in outpatient diabetology clinics in silesia region and are included into the study must have the informed consent signed and bioethics committee agreement has been obtained. machine learning approach will be implemented to discover the association between easy to obtain in everyday practice parameters, namely clinical, biochemical, and demographical ones to identify patients at the highest risk of cardiovascular disease. the secondary aim of the study is to utilize fundus imaging, electrocardiography, alongside demographic and clinical data in order to potentially diagnose neuropathy.

Eligibility criteria:
inclusion criteria: * for the group of hospitalized patients: diabetes type 1 or type 2 * for the subgroup of patients treated in outpatient diabetology clinics in silesia region: diabetes type 1 or type 2 exclusion criteria: 1. for the group of hospitalized patients: * types of diabetes other than type 1 and type 2 diabetes * death during hospital stay * terminal stage of cancer. 2. for the subgroup of patients recruited form outpatient diabetology clinics: * lack of an informed consent * types of diabetes other than type 1 and type 2 diabetes * malignant neoplasms * terminal stage of neoplasm * end-stage renal disease * malabsorption syndrome * active infection * primary hyperparathyroidism

Keywords: cardiovascular disease diabetes mellitus
evaluation of penile prosthesis pump manipulation

Conditions: Penile Prosthesis

Summary: erectile dysfunction is a highly prevalent pathology. when oral or injectable pharmacological treatments prove ineffective, the treatment of choice is penile prosthesis which provides the possibility of sexual activity with penetration. unfortunately, current prostheses are difficult (or even impossible) to manipulate for some patients. many patients underutilize their device due to difficulties in using the pump related to mechanical issues (difficult grip, lack of strength, etc.) or sensory issues (altered proprioception, etc.), resulting in an inability to achieve rigidity that allows optimal satisfaction for the patient and/or partners. these difficulties correspond to a significant portion of dissatisfaction among patients with penile prostheses. actually, no study has evaluated patients' ability to manipulate the pump of their penile prosthesis, as well as the association between these manipulation abilities, the rigidity of erections with a penile prosthesis, and patient and partner sexual satisfaction. in this descriptive study, the primary outcome is to describe the manipulation abilities of patients with penile prostheses during follow-up consultations after prosthesis implantation. the secondary outcomes are to estimate the association of various markers related to penile prosthesis manipulation (overall hand grip strength, pinch grip strength, proprioception, and discrimination) with * rigidity of erections with penile prosthesis * patient's sexual satisfaction * partner's sexual satisfaction * satisfaction related to pump manipulation


Eligibility criteria:
inclusion criteria: * the patients will be included based on the following criteria: * adults * erectile dysfunction, and had undergone penile prosthesis implantation for more than 3 months * able to comprehend the nature and purpose of the research * having provided informed consent the partner will be included based on the following criteria : * adults * having a partner who meets the inclusion criteria * able to comprehend the nature and purpose of the research * having provided informed consent exclusion criteria: * patients with a dysfunctional penile prosthesis (reservoir, pump, or cylinders anomaly) * adults subject to legal protective measures. * individuals not affiliated with a social security scheme or beneficiaries of a similar scheme.

Keywords: erectile dysfunction penile prosthesis manipulation difficulties erection's rigidity sexual satisfaction
a cognitive behavioral therapy-based text message intervention for methamphetamine dependence

Conditions: Amphetamine-Related Disorders

Summary: this phase i behavior therapy development study seeks to improve treatment outcomes for methamphetamine (ma)-dependent subjects by developing a novel cognitive behavioral therapy- (cbt-) based short message service (sms) text messaging intervention.


Eligibility criteria:
inclusion criteria: * english-speaking adults ≥ 18 years who are seeking treatment for ma addiction. * own a cellular phone with sms text messaging capability and have an unlimited text messaging plan. * available to attend cbt therapy groups. * agreeable to conditions of the study and signed an informed consent form. exclusion criteria: * projected to be unavailable \> 12 hours/day to read and send text messages. * any medical or psychosocial condition that would preclude safe, useful, or consistent participation,

Keywords: methamphetamine dependence texting short message service addiction amphetamine outpatient
impact of oral ibandronate 150 mg monthly on structural properties of bone in postmenopausal osteoporosis (spimos-3d)

Conditions: Osteoporosis, Postmenopausal

Summary: efficacy: to investigate changes of structural bone properties in vivo using 3dpqct ("xtreme" ct, scanco) in monthly oral ibandronate therapy for women with postmenopausal osteoporosis. major structural bone parameters which determine bone strength and predict fracture risk earlier and more precisely are measurable in vivo by 3dpqct. safety: to assess the tolerability and safety of ibandronate therapy


Eligibility criteria:
inclusion criteria: * age between 60 and 75 years * menopause \> 5 years * spine (l1 - l4) or hip bmd ≤ -2.0 and \> -3.5 sd t-score measured by dxa * patients who, in the opinion of the investigator, are able and willing to comply with the protocol for its duration * written informed consent * 3dpqct measurable at both skeletal sites, distal tibia and radius exclusion criteria: * spine or hip bmd ≤ -3,5 sd t-score measured by dxa * vertebral fractures * multiple (\>2) low trauma peripheral fractures * disease/disorder known to influence bone metabolism * history of major upper gastro-intestinal (gi) disease * diagnosed malignant disease within the previous 10 years * previous treatment with a bisphoshonate at any time * treatment with fluoride for osteoporosis (dose greater than 10 mg/day) within the last 12 months, or for more than 2 years (total duration) * treatment with pth and similar agents or strontium ranelate at any time * treatment with other drugs affecting bone metabolism within the last 6 months * chronic systemic corticosteroid treatment * estrogens, progestins, serms, anabolic steroids, active vitamin d analogues/metabolites, calcitonin * calcineurin inhibitors (e.g. cyclosporine, tacrolimus) or methotrexate * total serum calcium \ 2.6 mmol/l * vitamin d deficiency (serum 25-hydroxy vitamin d \< 12 ng/ ml) * alt above triple upper limit of normal range * renal impairment (serum creatinine \> 210 µmol/l) * contra-indications for ibandronate, calcium or vitamin d * employees of the centre for muscle and bone research, or their relatives

Keywords: bone structure ibandronate
adl-pdt under routine clinical conditions in patients with actinic keratosis

Conditions: Actinic Keratoses

Summary: the objective of this non-interventional study (nis) is to gain comprehensive insights into the practicability of adl-pdt with metvix® in patients with actinic keratoses under real-world conditions.

the objective of this non-interventional study (nis) is to gain comprehensive insights into the practicability of adl-pdt with metvix® in patients with actinic keratoses under real-world conditions. furthermore, this nis will document the efficacy, satisfaction, safety and tolerability of adl-pdt with metvix® in routine use according to the label. the observational study is designed as a multicenter study, covering all parts of germany. participating investigators are dermatologists experienced in adl-pdt with an adequate pool of patients with actinic keratoses. the observation time per patient will comprise up to 6 months, including up to 4 visits.

Eligibility criteria:
inclusion criteria: * written informed consent to participate in the study * age ≥18 years * thin or non-hyperkeratotic and non-pigmented actinic keratoses (ak) on the face or scalp (olsen grade 1 or olsen grade 2) * the decision to undergo adl-pdt with metvix® was made independently of this study * no contraindication (according to the smpc) exclusion criteria: * hypersensitivity to the active substance or to one of the other ingredients listed in section 6.1 of the smpc or other ingredients, including peanut oil, peanut or soy. * morpheaform basal cell carcinoma * porphyria * pregnancy
a non-interventional study with advanced lung squamous cell carcinoma

Conditions: Advanced Lung Squamous Cell Carcinoma

Summary: this is a descriptive observational study, in which data are collected in an epidemiological fashion and prospective. this study does not intend to intervene the current medical practice of the recruited patients.


Eligibility criteria:
inclusion criteria: * patients must be ≥18 years. * provision of fully informed consent prior to any study specific procedures. * advanced or metastatic lung squamous cell carcinoma confirmed by histology or cytology. * according to the recist 1.1 standard, the patient must have at least one measurable lesion. exclusion criteria: * none
gsi cardiac on revolution apex - us

Conditions: Coronary Computed Tomographic Angiography; Myocardial Infarction (MI); Cardiac Catheterization

Summary: the goal of this clinical data collection study is to collect raw ct scan data using a new gsi cardiac mode on ge healthcare's revolution apex ct system. two groups of participants will be enrolled: a) participants scheduled to undergo a coronary ct angiography (ccta) as part of their standard of care b) participants scheduled to undergo a cardiac catheterization or have a history of heart attack participants in group a will: -have a standard of care ccta immediately followed by a research gsi cardiac scan participants in group b will: -have a research ccta immediately followed by a research gsi cardiac scan both groups will be in the study for approximately 1 day. there are no follow-up visits after the day of scan.


Eligibility criteria:
inclusion criteria: subjects may be included in this study if they meet the following criteria: 1. who are ≥18 years of age; 2. able to sign and date the informed consent form; and, 3. cohort a: undergoing a scheduled clinically indicated ccta; or, 4. cohort b: known history of myocardial infarction or undergoing a clinically indicated cardiac catheterization due to known pathology. exclusion criteria: subjects may be excluded from participating in study if they meet any of the following criteria: 1. who are pregnant or lactating; 2. who were previously enrolled in this study; 3. anyone with known or suspected allergy to iodinated contrast agents; 4. anyone with known or suspected renal insufficiency as determined by site medical personnel; 5. who are in need of urgent or emergent care; 6. who have any conditions that, in the opinion of the pi or designee, would interfere with the evaluation of the results or constitute a health hazard for the subject; 7. who are unwilling to have gehc personnel present for the ct exam; and, 8. cohort a: undergoing a scheduled clinically indicated ccta for anatomy assessment (aberrant origin, etc.)
chw intervention to improve nutrition security of patients with hypertension

Conditions: Hypertension; Nutrition, Healthy; Food Insecurity; Community Health Worker

Summary: the goal of this study is to implement and evaluate a randomized pilot study of a 4-month nutrition-enhanced community health worker (chw) intervention for primary care patients with nutrition insecurity and poorly controlled hypertension. the nutrition intervention will be added to the pre-existing massachusetts general hospital chw hypertension (basic chw) program that provides hypertension education, coaching about adherence to medications and primary care visits, and home bp cuffs and promotion of bp self-monitoring over the course of approximately 4 months.

the goal of this study is to implement and evaluate a randomized pilot study of a 4-month nutrition-enhanced chw intervention in primary care patients with nutrition insecurity and poorly controlled hypertension. the nutrition intervention will be added to the pre-existing massachusetts general hospital chw hypertension (basic chw) that provides basic hypertension education, coaching about adherence to medications and primary care visits, and home bp cuffs and promotion of bp self-monitoring over the course of approximately 4 months. the chw nutrition intervention curriculum is tailored to the needs and preferences of a food-insecure population with limited resources. nutrition education materials will be provided to participants, including a booklet of nutrition information and a summarized version of key points on a brochure that they can use as a quick reference when grocery shopping. nutrition education will focus on reducing sodium, saturated fats, and added sugars and increasing fruits, vegetables, and whole grains. much of the educational material is based on a traffic-light system. these topics are organized into four modules: nutrition label reading, grocery shopping, meal-planning, and healthy cooking.

Eligibility criteria:
inclusion criteria: * eligible to participate in the massachusetts general hospital chw hypertension program (age 21 years or older, uncontrolled hypertension, patient at one of 5 participating primary care clinics; either identifies as a minoritized race/ethnicty or is low-income); speaks english or spanish exclusion criteria: * declines participation in chw hypertension program; does not speak english or spanish
association between the level of ev-tf and the occurence of pulmonary embolism in patients with ards

Conditions: Acute Respiratory Distress Syndrome

Summary: in this study, 120 patients with acute respiratory distress syndrome (ards) will be included on a two years-period in an intensive care unit (assistance publique des hôpitaux de marseille, france). those patients will benefit from a blood test at inclusion in order to measure several coagulation biomarkers, including ev-tf. subsequently, these patients will be treated according to the usual practices of the department, following recommendations. patients who received an injected ct scan between day 5 and day 28 will be divided into two groups based on the presence or absence of a pulmonary embolism on imaging. the measured values of ev-tf levels and other studied biomarkers will be compared between these two groups in order to detect a possible association between them and the diagnosis of pulmonary embolism. it should be noted that patients receiving an injected ct-scan between day 5 and day 7 will be included in the main analysis while those receiving it between day 8 and day 28 will be included in the secondary analysis. others will be excluded from any analysis. at the same time, several collections of clinical data will be carried out: on day 1, day 7, day 28, and on the day of the ct scan if it is performed at another time.


Eligibility criteria:
inclusion criteria: * patient 18 years of age or older, * patient who has given his/her non-opposition to participate in this study, or alternatively, patient for whom a relative has given his/her non-opposition to participate in this study, * patient admitted to intensive care for less than 24 hours, * patient with ards according to the berlin criteria, * hypoxemia with pao2/fio2 ratio ≤ 300 on mechanical ventilation under peep ≥ 5 cmh2o, * bilateral alveolar-interstitial opacities on chest imaging (chest x-ray or ct), * exclusion of a cardiogenic cause on echocardiography, * acute or subacute onset within 7 days based on the clinical-radiological profile. exclusion criteria: * positive sars-cov-2 pcr in a pharyngeal or respiratory sample (cytobacteriological examination of sputum, bronchial aspiration or bronchoalveolar lavage) prior to admission to the intensive care unit, * patient with a pathology affecting the coagulation process or endothelial function (hemophilia, von willebrand disease, etc.), * patient receiving curative anticoagulant treatment before admission to the intensive care unit, * patient undergoing extracorporeal veno-venous respiratory assistance (ecmo-vv) before admission to the intensive care unit, * patient undergoing extra-renal purification with systemic anticoagulation with heparin before admission to the intensive care unit, * persons referred to in articles l. 1121-5 to l. 1121-8 of the public health code (minor patients, adult patients under tutorship or guardianship, patients deprived of their liberty, pregnant or nursing women), * moribund patients for whom the life expectancy is less than 24 hours according to the opinion of the investigating physician.