Kornimate/medical-research-clean huggingface dataset:
effects of classic and modified cimt on quality of life of children with hemiplegic cp

Conditions: Hemiplegic Cerebral Palsy

Summary: the purpose of this research is to see the effect of classic constraint-induced movement therapy and its modified form on quality of life of children with hemiplegic cerebral palsy. randomized controlled trials with 2-3 weeks follow-up. the sample size is 40. the subjects are divided in two groups, 20 subjects in classical cimt group and 20 in modified cimt group. study duration is of 6 months. sampling technique applied will be purposive non probability sampling technique. only 4-12 years individual with hemiplegic cerebral palsy are included. tools used in the study are cerebral palsy (quality of life) and kid screen 27.

both ccimt and mcimt are effective treatments to improve quality of life of children with cp. however conflicting evidence is present on which one of these is more effective and no final conclusion can be made to date. this study intends to add to the literature and contribute in reaching final conclusion about the superiority of either intervention. the purpose of this study was to see the psychosocial effect (quality of life) of cimt and its modified form on hcp

Eligibility criteria:
inclusion criteria: * 4 to 12 years cp with unilateral, bilateral or severely asymmetrical impairment manual ability classification system(macs) i, ii or iii wrist extension capacity at least 20°; fingers with 10° of complete flexion children able to follow command exclusion criteria: * children also having disabilities other than cerebral palsy contractures that significantly limit functional arm use. children with mr

Keywords: constraint induced movement therapy cerebral palsy cpqol
clinical assessment of bifluorid 10 vs varnish fluoride on the exposed hypersensitive cervical dentin in adult patient

Conditions: Hypersensitivity; Dentin Sensitivity

Summary: aim of the study will be conducted to compare the efficacy of bifluoride (naf and caf) versus conventional fluoride varnish (sodium flouride) in the management of hypersensitivity of exposed cervical area in adult patients over 2 month


Eligibility criteria:
inclusion criteria: * healthy patient with free medical history. * age range 18-60 years old. * good oral hygiene * patients suffering from pain due to dentin hypersensitivity. * patient with sound first molar . exclusion criteria: * patients using desensitizing agents, receiving periodontal treatment or had received nonsurgical periodontal treatment in the last three months. * patient wearing orthodontic appliance. * patient with teeth having a painful condition involving the pulp and periapical region. * patients who had allergy to materials will be used in the study. * pregnancy. * patient who does not consent to participation. * patient who does not attend to the follow up. * a patient who has a carious first molar.
diagnostic accuracy of serum bilirubin in the prediction of perforated appendicitis

Conditions: Appendicitis

Summary: hyperbilirubinemia is reported to be a positive predictor in diagnosing perforated appendicitis. therefore we analysed the diagnostic accuracy of serum bilirubin in discriminating between perforated and simple/no appendicitis. methods: all consecutive patients undergoing appendectomy for suspected appendicitis from may 2009 to august 2011 were analysed. primary endpoint was the diagnostic accuracy of serum bilirubin levels to detect perforated appendicitis.


Eligibility criteria:
inclusion criteria: * all patients undergoing appendectomy for suspected appendicitis exclusion criteria: * preexisting liver disease
randomized controlled trial of interpersonal psychotherapy for depression and ptsd among hiv+ women in kenya

Conditions: Depression; Posttraumatic Stress Disorder; HIV

Summary: the aim of this study is to conduct a 12-week ipt+tau versus wait list tau in a cohort of hiv+gbv+ women in nyanza province to relieve depression and ptsd and improve arv adherence. this pilot study will provide data on the efficacy trends, acceptability and feasibility of our ipt intervention and will generate preliminary findings for an r01-funded intervention to test the intervention's efficacy for remediating the effects of gbv trauma on mental health and hiv-related outcomes. hypothesis 1: ipt+ tau will be more effective for reduction of depression and ptsd than tau alone. hypothesis 2: ipt+tau will be acceptable and feasible.

we will use a parallel design with faces treatment as usual (tau) control to provide ipt once per week for twelve weeks to hiv+gbv+ women meeting cidi diagnostic criteria for depression (mdd, dysthymia, minor depression) and ptsd secondary to gbv. blocked randomization will be used to evenly distribute 120 participants to (1) ipt + tau or (2) tau for 12 weeks. the tau group will be offered ipt treatment following the initial 12 week trial. thus, all study subjects will receive tau throughout the study and they will all receive ipt in either the first or second half of the study. my research team at faces will be recruited for ipt training as potential therapists in the ipt pilot. a run-in study design will be used, assigning one training case apiece to each of the 8 therapists to practice ipt skills. both ipt + tau and tau groups will be measured at baseline and weeks 12, 24 and 36 by blinded assessment. at faces, tau resources for hiv+gbv+ women include medical professionals, counseling, community elders, church leaders, police, and a pro-bono legal aid, all of who have all been involved with past faces gbv interventions.

Eligibility criteria:
inclusion criteria: * .(1) hiv+ women enrolled at faces-kisumu; (2) diagnosis with depression (mdd, dysthymia, minor depression) and ptsd secondary to gbv\* on the cidi; (3) ability to attend weekly therapy sessions and repeated measures; (4) age greater than 18 years; (5) ability to give informed consent. exclusion criteria: * (1) cognitive dysfunction requiring a higher level of care or compromising ability to participate in ipt\*\*; (2) severe thought or mood disorder symptoms requiring a higher level of care or interfering with ability to participate in ipt; (3) current drug and alcohol dependence requiring substance use treatment. although ptsd is associated with substance abuse in euroamerican populations, a recent study of 5175 faces patients found that over 80% of this lmic population use no alcohol.

Keywords: interpersonal psychotherapy hiv women gender based violence mental health africa kenya global mental health hiv treatment adherence
salient aquamantys spine trial

Conditions: Blood Loss

Summary: the purpose of this study is to compare standard of care hemostasis techniques with and without the use of aquamantys in reducing peri-operative blood loss.

the primary objective of the study is to assess the effectiveness of aquamantys in reducing peri-operative blood loss compared with standard electrocautery secondary objectives include : * rate and volume of transfusions * evaluating the reduction in hemoglobin and hematocrit values post- operatively * los costs, and operative time * gathering operator feedback on qualitative criteria, including ease of use and surgical visualization between the two treatment groups

Eligibility criteria:
inclusion criteria: 1. be candidate for three level (or greater) fusion surgery from t1 to s1 utilizing a direct posterior approach 2. male or female 18 to 70 years of age (inclusive) 3. must sign the irb approved informed consent form exclusion criteria: 1. undergoing spinal fusion for \< 3 lumbar levels, or using an approach other than direct posterior 2. undergoing an interbody fusion 3. planned use of hypotensive anaesthesia 4. pregnant or lactating 5. morbid obesity, defined as body mass index (bmi) greater than 40 6. previously diagnosed coagulopathy or bleeding diasthesis 7. currently, or within the previous 7 days prior to surgery, taking any medications that would produce bleeding diathesis including, but not limited to nsaids, aspirin, clopidogrel (plavix), ticlopidine, or valproic acid 8. history of significant cardiac disorders that would necessitate special fluid management protocols 9. serious trauma other than that confined to the spine 10. history of acute myocardial infarction and/or acute angina within the past year prior to enrollment 11. pt/inr \>1.3 in the 14 days prior to surgery 12. ptt \> 40 in the 14 days prior to surgery 13. platelet count \<100k in the 14 days prior to surgery 14. based on clinical history, physical exam and subject presentation, subject has or is suspected to have a history of alcohol and/or drug abuse that would preclude subject from providing adequate consent and/or complying with study requirements 15. prisoner or transient 16. enrolled in another drug or device investigational study (currently or within past 30 days) 17. unable or unwilling to sign the informed consent form or comply with protocol specified procedures

Keywords: blood loss transfusions instrumented spinal fusion
a pharmacogenomics study of safety and efficacy of enalapril or enalapril-folic acid therapy in hypertensive patients.

Conditions: Enalapril Adverse Reaction; Pharmacogenomics; Stroke

Summary: dry cough is the most common adverse reaction of angiotensin converting enzyme, including enalapril, in chinese population. clinical observations suggest that the incidence of acei-induced dry cough is different between chinese and other racial groups, however, there is still lack of research data in chinese. stroke is the second leading cause of death in the world and leading cause of death in china. except the known risk factor such as hypertension, high homocysteine level, folic acid deficiency, the impact of genetics should not be ignored. in this study, we will investigate whether there are specific genotypes which may predict the incidence of (1)enalapril-induced dry cough in chinese and (2)first stroke in hypertensive patients taking enalapril or enalapril-folic acid therapy, so as to provide a basis for developing guidelines on precision medication in enalapril therapy apply to chinese population.


Eligibility criteria:
inclusion criteria: * patients taking enalapril or enalapril-folic acid therapy * signed informed consent. exclusion criteria: * patients not taking enalapril treated * intolerance or unwillingness to blood sample collection.
the clinical of stannous fluoride toothpaste and a newly designed toothbrush compared to colgate cavity protection toothpaste and a regular toothbrush in reducing plaque and gingivitis.

Conditions: Plaque; Gingivitis

Summary: qualified subjects will be enrolled and randomly assigned to either of the two study groups based on their initial plaque and gingivitis scores. during the first visit, subjects will undergo three key procedures: 1) evaluation for baseline plaque and gingivitis, 2) brushing with the assigned regimen products for two minutes, and 3) assessment for post-brushing plaque only. subjects will be provided with clear instructions for regimen product usage and will be expected to adhere to these instructions. follow-up evaluations for plaque and gingivitis will be conducted at one week, six weeks, and three months after initiation of regimen product use. throughout the study period, continuous monitoring for adverse events will be carried out for all subjects.


Eligibility criteria:
inclusion criteria: * subjects, ages 18-70, inclusive. * availability for the three-month duration of the clinical research study. * good general health. * minimum of 20 uncrowned permanent natural teeth (excluding third molars). 5. initial gingivitis index of at least 1.0 as determined by the use of the loe and silness gingival index. * initial plaque index of at least 1.5 as determined by the use of the quigley and hein plaque index (turesky modification). * signed informed consent form exclusion criteria: * presence of orthodontic bands. * presence of partial removable dentures. * tumor(s) of the soft or hard tissues of the oral cavity. * advanced periodontal disease (purulent exudate, tooth mobility, and/or extensive loss of periodontal attachment or alveolar bone). * five or more carious lesions requiring immediate restorative treatment. * antibiotic use any time during the one-month period prior to entry into the study. * participation in any other clinical study or test panel within the one month prior to entry into the study. * dental prophylaxis during the past two weeks prior to baseline examinations. * history of allergies to oral care/personal care consumer products or their ingredients. * on any prescription medicines that might interfere with the study outcome. * an existing medical condition that prohibits eating or drinking for periods up to 4 hours. * history of alcohol or drug abuse. * pregnant or lactating subjects
feasibility of telesurveillance and home cough assistance for amyotrophic lateral patients (als)

Conditions: Amyotrophic Lateral Sclerosis

Summary: the investigators want to test feasibility of a structured program of telesurveillance and home cough assistance for als patients.

background: amyotrophic lateral sclerosis (als) patients present reduction in the inspiratory and expiratory muscle strength, frequent secretions increase, insufficient expectoration ability with inevitable risk of acute respiratory failure (arf) and necessity of hospitalizations. recently, new mechanical tools (in-exoflator emersonr) are available in our hospital to help patients to expectorate during arf. it is well noted these patients are particularly reluctant to be hospitalized to avoid further worsening in their quality of life. aim: the investigators want to test feasibility of a structured program of telesurveillance and home cough assistance for als patients. methods: a telesurveillance program (tp), a pulsed saturimetric device, 2 hours educational hospital sections (air stacking with ambu balloon, manual manoeuvres and in-exoflator indications and use) will be offered to all als consecutive patients. in details the tp is structured as follows: 1) domiciliary telesurveillance by only one 24-h service centre (sc) for enrolled pts with als in hospital discharge phase, 2) patients - taken care of five days/week by a nurse-tutor (nt) and respiratory therapist (rt) according to a predefined appointments, 3) for 24-hr. duration (in case of symptoms) patients can call sc and talk to pneumologists that can intervene whenever needed for diagnostic-therapeutic adjustments. 4) in case of need the patient can contact the neurologist or psychologist; 5) the rt in accordance with pneumologist can decide for a domiciliary visit to patient. home rt accesses and in-exoflator activation will be prescribed when patients will present worsening of three points in psato2, 30% in peak cough expiratory flow (pcef), lack of cough ability with increase in secretions and or suctions necessity (in tracheotomy patients) and clinical symptoms (dyspnoea, fever, headache, somnolence). number of in-ex and air stacking activations, arf episodes, hospital accesses, antibiotic therapy, customer satisfaction, pcf/pef, mic-vc, respiratory function (mip, mep, fev1, fvc, fev1/fvc, abg), dyspnoea (borg scale), general disability (hoevelaken scale and als functional rating scale) and survival will be collected. expected results: 30 als patients (vc \< 80% and 40% with tracheotomy) will be enrolled after discharge from respiratory or neurological units of s. maugeri foundation. this study will allow: 1. to test a possible alternative of care for als patients 2. to check patients and caregivers' acceptance 3. to measure time consuming for care team 4. to quantify patient's comfort 5. to test costs/effectiveness ratio.

Eligibility criteria:
inclusion criteria: * 40 als patients (vc \< 80% with or without tracheostomy)will be enrolled after discharge from respiratory or neurological units of s. maugeri foundation. exclusion criteria: * none

Keywords: home care home rehabilitation telemedicine als
clinical effect of phenytoin mucoadhesive paste on wound healing after oral biopsy

Conditions: Wound Healing; Pain

Summary: several studies have investigated healing effect of phenytoin.in this study we investigate healing effect of phenytoin mucoadhesive paste comparing to the usual mucoadhesive paste after oral biopsy.


Eligibility criteria:
inclusion criteria: * patients undergone oral biopsy exclusion criteria: * systemic disease

Keywords: inflammatory halo vas
physical exercise in postoperative bariatric surgery patients

Conditions: Physical Exercise; Bariatric Surgery; Morbid Obesity

Summary: this study aims to determine the effect of two types of exercise training on body composition, cardiopulmonary function and quality of life in people after undergoing bariatric surgery.

three groups will be studied: 1. control group (cg) 2. group of moderate intensity continuous aerobic exercise (gmict) 3. high intensity interval aerobic exercise group (ghiit) the cg will follow the usual protocol adopted by the hospital san juan de dios, curicó, chile. the protocol consists in delivering information about relevance of engage in regular physical exercise practice according to the world health organization (150 minutes of activity per week moderate physical or at least 75 minutes of intense physical activity), but do not include the patients in a supervised physical exercise program. the gmict will undergo a physical exercise program in which the aerobic component will be a moderate-intensity continuous exercise training (60% of the heart rate reserve). the ghiit will undergo the same exercise program of the gmict, but the aerobic component will be a high-intensity interval exercise training (10 sets of 1 min at 90% of heart rate reserve, with 1 min of rest between sets). all groups will receive a nutritional diet plan prescribed by a specialist bariatric nutritionist blinded to the participants group assignment. at the end of the study, the cg will be invited to enjoy the exercise program showing to be more effective. outcomes will be assessed at four time points: 1) one week before surgery; 2) 21 days after surgery (baseline before start exercise program); 3) 8 weeks after the beginning of the exercise program; and 4) one week after the end of intervention. main outcomes are: 1) body composition; 2) heart rate variability; 3) six-minute walk test and 4) quality of life. secondary outcomes will be: 1) maximal respiratory pressures; 2) flowmeter; 3) dynamometry of upper limb; and 4) squat test in 30 seconds. all procedures will be performed in the hospital of curicó, chile, at the department of physical medicine and rehabilitation service.

Eligibility criteria:
inclusion criteria: * persons between 18 and 65 years old, both sexes, who have undergone bariatric surgery, with medical authorization to perform physical exercise, that the wound healing process operative is in the final phase, which have been administered with subsequent anti thrombus treatment to surgery, who have no plans to change their place of residence within the current year. exclusion criteria: * persons who have had immediate complications after bariatric surgery (dehiscence anastomosis and operative wound dehiscence), presented any comorbidity decompensation after surgery, who are in the process of dialysis or who suffer from neuromotor disease.
blood eosinophil measurements in patients with chronic obstructive pulmonary disease

Conditions: Chronic Obstructive Pulmonary Disease

Summary: this study will assess the within-day variation of blood eosinophils in patients with chronic obstructive pulmonary disease (copd) in stable state and determine if there is a correlation between the blood eosinophils and certain clinical parameters.

copd is a heterogeneous disease, resulting in different phenotypes with varying clinical and pathophysiological characteristics. one of these pathophysiological features is chronic airway inflammation which can be eosinophilic of nature. blood eosinophils could be an accessible biomarker for this eosinophilic inflammation. eosinophil counts can fluctuate due to their short half-life in blood and due to a diurnal rhythm. more needs to be known about this diurnal rhythm and the different confounding factors and sources of within-subject variability of this biomarker.

Eligibility criteria:
inclusion criteria: * patients willing and able to give informed consent for participation in the study. * age 18 years or older. * diagnosis of copd according to gold (global initiative for chronic obstructive lung disease): post-bronchodilator tiffeneau index \<0.7), in a stable state of the disease. * a smoking history of \>10 pack-years exclusion criteria: * clinical diagnosis of asthma. * use of systemic corticosteroids (oral, intravenous or infiltration) up to six weeks before inclusion. * pregnancy. * a recent exacerbation of copd (\<4 weeks).
cannabis use patterns among cancer patients

Conditions: Hematopoietic and Lymphoid Cell Neoplasm; Malignant Solid Neoplasm

Summary: this study determines patterns of cannabis use among cancer patients. information collected in this study may help doctors to understand patient use of cannabis therapy, their knowledge and experiences with this therapy, benefits and risks associated with its use, and whether or to what extent they are discussing it with their health care providers.

primary objectives: i. to identify the frequency, modes, and duration of cannabis use, assess experiences with obtaining and using cannabis, as well as reasons for use and perceived risks and benefits of its use among cancer patients who are undergoing or have recently completed active treatment. ia. to uncover disparities in use of cannabis, perceptions of use, and communication with providers among cancer patients who are identify as racial and ethnic minorities, have low health or digital literacy, are of older age or low socioeconomic status. ii. among cancer patients with a known medical marijuana certification, assess the impact of cannabis on pain management, anxiety, anorexia, and quality of life, as well as their communication with their oncology team about their procurement and use of cannabis. outline: patients complete a survey about knowledge and awareness of medical cannabis, perceived risks and benefits of cannabis, mode and frequency of use (if applicable), impact on cancer-related symptoms, patient provider discussions about cannabis, and demographic characteristics including health and digital literacy.

Eligibility criteria:
inclusion criteria: * provide signed and dated informed consent form * english speaking * willing to comply with all study procedures and be available for the duration of the study * any individual \>= 18 years old * at least one medical or radiation oncology appoint within the last 3 years at one of the skcc cancer center campuses exclusion criteria: * non-english speaking * not a cancer patient at one of the skcc campuses * deceased