Kornimate/medical-research-clean huggingface dataset:
ultrasound-assisted lumbar puncture in children

Conditions: Fever

Summary: the aim of this study is to determine if emergency physician performed ultrasound-assisted lumbar puncture improves first-time success rates in a pediatric population. this will be done by comparison with current landmark-based approach to the procedure.


Eligibility criteria:
inclusion criteria: * patient less than 19 years of age * requiring a lumbar puncture as part of their work-up, as determined by the treating pediatric emergency physician. exclusion criteria: * • patients with known spine or spinal cord abnormalities * patients with ventricular shunts * patients deemed too unstable to have procedure performed * patients at risk for significant bleeding (coagulopathy, thrombocytopenia, etc) * parents unable to give consent or patients unable to assent for an acute reason

Keywords: lumbar puncture point of care ultrasound children
effects of parenteral nutrition in hsct

Conditions: Hematologic Malignancy

Summary: nutritional therapy implementation in hematopoietic stem cell transplantation (hsct) have undergone changes recently due to new conditioning regimen and graft versus disease prophylaxis, novel enteral and parenteral nutrition solutions: the value of enteral nutrition is increasing, the indications for parenteral nutrition are becoming more strict. the study aims to identify the role of parenteral nutrition in the context of rapidly changing supportive care approaches in hsct

the study is interventional: in children and adolescents (2-17 years), adults with blood malignancy and inherited diseases who underwent autologous or allogeneic hsct, nutritional status, parenteral nutrition tolerability and effectiveness will be assessed before and one month after hsct. all patients who require parenteral nutrition will pass randomization via envelope technique - solutions containing glucose/amino acids or glucose/amino acids/lipid emulsions. the results will be compared with a control group which will not receive additional nutritional support. the methods used for measurement of nutritional status are: weight, body mass index, bioimpedance and hand grip strength (for adults only), blood tests, diet amount record.

Eligibility criteria:
inclusion criteria: * autologous hsct * allogeneic hsct * patients with indications for parenteral nutrition defined as unable to eat more than 50% of oral food intake due to posttransplant complications which leads to malnutrition and malabsorption * signed informed consent * age \> 2 years exclusion criteria: - secondary hsct

Keywords: hsct parenteral nutrition
online tai chi plus fitbit after acs

Conditions: Acute Coronary Syndrome; Physical Inactivity

Summary: this projects studies the role of tai chi exercise and wearable fitness trackers to promote physical activity in acute coronary syndrome (acs) survivors.

this is a two-site randomized controlled trial taking place at beth israel deaconess medical center in boston, ma and the miriam hospital in providence, ri. seventy (n=70) physically inactive acs survivors will be randomized to either a 6-month group tai chi program (remotely-delivered classes on zoom) integrated with a wearable self-monitoring/feedback device plus enhanced usual care (euc), or to euc alone. euc will include usual care provided by participants' providers integrated with printed chd risk factor education materials. assessments will be conducted in-person at baseline, 6 months (end of treatment), and 9 months. our primary outcomes will be focused on study feasibility and acceptability. secondary outcomes include the following patient-centered outcomes: objectively measured (via accelerometry) moderate-vigorous physical activity, light physical activity, sedentary time, cognitive-behavioral constructs (exercise self-efficacy, intrinsic motivation, depression, stress, hrql), and cardiometabolic measures (exercise capacity, body weight, lipid profile, blood pressure, fasting plasma glucose).

Eligibility criteria:
inclusion criteria: 1. history of acs (unstable angina, nstemi, and stemi, defined per current aha/acc criteria); 2. age ≥ 18; 3. being physically inactive (i.e., \< 150 min/week of moderate-intensity aerobic pa); 4. absence of contraindications to physical exercise per the participant's provider evaluation; 5. access to a digital device with internet connection; 6. having an active email account and ability to check email at least weekly; 7. physician clearance to participate in low-moderate intensity exercise (tai chi), including a statement that there is no contraindication to exercise based on post-acs stress test and other factors, as appropriate; 8. english speaking exclusion criteria: 1. inability or unwillingness to give informed consent; 2. blood pressure \>200/110 or orthostatic systolic blood pressure decrease \>20 mmhg at the baseline visit; 3. uncontrolled/untreated atrial or ventricular arrhythmias or 3rd degree av block; 4. within 3 months of a diagnosis of pericarditis or myocarditis; 5. medical conditions likely to limit lifespan to less than one year; 6. new york heart association (nyha) functional class iv; 7. severe cognitive impairment (bomc \>10);139 8. orthopedic problems prohibiting tc practice; 9. ongoing tc or other mind-body training (i.e., meditation, tc, or yoga) at least weekly; 10. current enrollment in cardiac rehabilitation; 11. untreated severe depression (phq\>=20); 12. conditions likely to affect study compliance (i.e., moving out of study area, substance use, ongoing untreated psychosis); 13. symptoms of unstable cardiovascular disease (e.g., shortness of breath or chest pain at rest and/or canadian cardiovascular society angina class iii-iv)

Keywords: tai chi fitness tracker
evaluation of irritancy/allergic sensitivity to natural personal-care products by patch tests

Conditions: Cutaneous Patch; Dermatitis; Allergy; Cosmetic Allergy; Eczema; Contact, Allergic

Summary: the purpose of the study is to determine if any of mother's choice' all-natural personal-care products cause either irritation or allergic reaction when applied to both normal or sensitive skin. each product will be tested on the skin using patch tests.

volunteers will be seen on day #0 and the study purpose will be explained. each volunteer will be interviewed to determine if he/she has any exclusion criteria. if there is no contraindication, and agreement is achieved,consent forms will be signed. volunteers will be examined by a lactic acid test to determine if he/she has normal or sensitive skin. in this test, a finn's cell (plastic cell, size 1\*1 cm) with lactic acid (50 microliter, 10%w/v) will be placed on the volunteer's cheek for ten minutes. the volunteer will be defined as "sensitive" or "normal" according to the degree of discomfort they report. patch-tests will be performed in the standard method. the materials to be tested will be placed in finn's cells and attached to the participants healthy skin's back by a plaster (micropore).the chambers will be left on the skin for 48 hours. the test will be read by a specialist one hour after chambers' removal and 48 hours afterwards. any erythema,edema, blisters, pustules or erosions on the skin in the patch area will be considered a positive response, and will be evaluated by clinical tools as being of the irritant or the allergic type. in case of uncertainty we may use a confocal microscope for in vivo diagnosis. ingredients: appropriate concentrations and solvents of the test materials will be prepared according to accepted standards (refer to: anton c. de groot: patch testing, 3ed edition, wapserveen, the netherlands, 2009).leave on products will be tested 'as is'. rinse off products will be diluted to 5% and 0.5%. if the skin stays normal after the patch removal, it means that contact with the material did not cause allergy or irritation.

Eligibility criteria:
inclusion criteria: - healthy adults exclusion criteria: * pregnant subjects * subjects with an allergy or a skin disease which interferes with the proper results of the tests. * subjects who are taking medications which can interfere with the proper results of the tests. for example: systemic corticosteroids, topical steroids applied to the test area. * subjects with sun or phototherapy induced tanning at the test area. * subject who had been participating in allergy tests within eight weeks prior to the present tests.

Keywords: patch-testing personal-care cosmetic dermatitis allergy sensitive skin
fit 24 technology intervention youth

Conditions: Diabetes Mellitus, Type 2

Summary: the purpose of this study is to examine the effects of a goal-setting intervention that utilizes a fitbit device and text messaging to improve physical activity and sleep in hispanic adolescents with obesity.

hispanic adolescents are disproportionately burdened by obesity and type 2 diabetes compared to non-hispanic white youth. disparities in t2d emerge early in life and are driven in part by unhealthy lifestyle behaviors including low levels of physical activity, excessive time spent in sedentary behaviors and short sleep durations. given that hispanic youth are the fastest growing pediatric subgroup in the u.s., developing strategies to promote healthy lifestyle behaviors and addressing t2d disparities is a public health imperative. wearable activity monitoring devices like fitbits are designed to continuously monitor both wake time and sleep behaviors. therefore the purpose of this study is to examine the feasibility, acceptability, and preliminary efficacy of a 12-week technology-based intervention that uses a fitbit and text messages grounded in the self-determination theory to promote healthy lifestyle habits and reduce risk for type 2 diabetes among a hispanic adolescents with obesity.

Eligibility criteria:
inclusion criteria: * self identify as hispanic or latino * obese, defined as body mass index percentile (bmi%) ≥ 95th percentile * ages of 14-16 years * own his or her own cellphone. exclusion criteria: * taking a medication(steroids) or diagnosed with a condition (i.e. sleep (i.e. sleep apnea) that influences activity, sleep, and/or cognition * recent hospitalization or injury that prevents normal physical activity * pregnant * currently enrolled in an exercise program or currently using a personal activity monitoring device like fitbit.
is endothelial function a predictor of successful ablation therapy provided to patients with atrial fibrillation?

Conditions: Atrial Fibrillation

Summary: the purpose of this study is to assess whether normal endothelial function in patients with atrial fibrillation undergoing ablation procedure increases the chances of a favorable clinical outcome and maintaining sinus rhythm following ablation

in the recent years, increasing evidence is linking inflammation to afib. in addition, it has been shown that ablation improves endothelial function, suggesting that afib might be associated with the etiology of endothelial dysfunction. the objective of this study is to assess endothelial function using endo-pat2000 and its correlation to clinical outcome following ablation of patients with atrial fibrillation (afib).

Eligibility criteria:
inclusion criteria: * all patients with af considered eligible for ablation treatment may be included in this study (following unsuccessful attempts with aad). * patients on optimal anticoagulation therapy * the minimum af documentation required as defined by the heart rhythm society exclusion criteria: * patients age below 18 years * cases with extremely abnormal anatomy (i.e., inverted heart) * moderate or severe mitral valve disease or mitral prosthetic valve * ejection fraction less than 30% * left atrial anteroposterior diameter more than 50 mm evaluated by echo or ct data (up to 6 months old).. * previous atrial fibrillation ablation occurred less than 6 months prior * left atrium thrombus * acute infective disease or sepsis in the last 3 months * acute myocardial infarction in last 3 months * reduced expectancy of life (less than 12 months) * patient participating in another clinical study that investigates a drug or device unless prior approval is given by the sponsor * psychologically unstable patient or denies to give informed consent * deformities of the digits of the upper extremities, which preclude adequate signal acquisition * patients under the effect of short-acting nitroglycerin (3 hours washout period) * patient suffering from a medical condition prohibiting blood flow occlusion in both arms

Keywords: afib af ablation endopat endothelial dysfunction pat
intensive care unit (icu) sleep quality and neurocognitive performance

Conditions: Neurobehavioral Manifestations; Sleep Deprivation; Dyssomnias

Summary: the purpose of this study is to understand patients' neurocognitive performance shortly after discharge from the medical intensive care unit (micu) and the potential effect of sleep quality in the micu on those neurocognitive outcomes. the investigators hypothesize that post-icu neurocognitive function and patient overall icu sleep experience will improve through a pre-existing micu sleep improvement initiative.

despite decades of scientific interest in evaluating sleep among critically ill patients, little is known about the effects of intensive care unit (icu)-associated sleep disturbances on patient outcomes. furthermore, few interventions have been rigorously evaluated to demonstrate efficacy in improving sleep in the icu and associated patient outcomes. post-icu neurocognitive test performance data from this study will be linked to a pre-existing quality improvement (qi) project for patient sleep in the micu. we hypothesize that patients' post-icu neurocognitive performance (delirium status, attention, short-term memory, processing speed, and executive function) will positively correlate with scores from a previously-published sleep in the intensive care unit questionnaire. in addition, we hypothesize that both neurocognitive performance and the sleep in the intensive care unit questionnaire will improve during the multi-stage micu-wide sleep qi project. our project will provide valuable empirical evidence to help support guidelines for promoting sleep in the icu setting.

Eligibility criteria:
inclusion criteria: * \>=18 years old * spent at least one full night (i.e. 7pm to 7am) in the johns hopkins hospital (jhh) medical intensive care unit (micu). * discharged directly from micu to an in-patient medical step-down or ward bed at jhh. exclusion criteria: * previously enrolled in the study (i.e. repeat discharge from micu) * pre-existing cognitive impairment, including hepatic encephalopathy, long-term alcohol abuse, and neurological disease (e.g., dementia, prior stroke, cerebral palsy, traumatic brain injury, active seizures) * unable to speak and/or understand english * \> 96 hours between micu discharge and testing * visual or hearing impairment, inability to read, or inability to use a writing instrument preventing administration of the neurocognitive tests * spent at least one night in an icu other than jhh micu during current hospitalization

Keywords: neurocognitive function sleep quality critical care quality assurance, health care
non-interventional study describing epidemiology, prognosis and patient healthcare costs in france, 2010-2017

Conditions: Lung Diseases, Interstitial; Lung Disease With Systemic Sclerosis

Summary: interstitial lung diseases (ilds) are a heterogeneous group of disorders, which encompass a wide range of conditions. in some patients with fibrosing ilds, a progressive phenotype similar to that observed in idiopathic pulmonary fibrosis (ipf) may develop during the course of the disease (pf-ild), including patients with systemic sclerosis (ssc)-related ild. the aim of the study is to estimate the incidence and prevalence and to describe the characteristics of patients diagnosed with non-ipf pf-ild and ssc-ild, to describe the natural course of disease, and to explore the correlation between mortality and forced vital capacity (fvc) of the patients with non-ipf pf-ild. this study will be based on two data sources: the french national medico administrative database (snds) and the ild cohort from the national french center for rare pulmonary diseases in lyon, france.


Eligibility criteria:
inclusion criteria: * patients hospitalized for pf-ild and ssc-ild in france between 01/01/2010 and 31/12/2017 * men or women aged ≥ 18 years old at diagnosis exclusion criteria: * patients treated by anti-fibrotic * patients diagnosed with ipf

Keywords: progressive fibrosing interstitial lung disease systemic sclerosis-associated interstitial lung disease
high and low intensity expiratory muscle strength training in patients with obstructive sleep apnea syndrome

Conditions: Obstructive Sleep Apnea Syndrome

Summary: the effect of expiratory muscle strength training (emst) on sleep quality, disease severity, and respiratory muscle strength has been previously investigated in osa syndrom. only the effects of the high-intensity short-term emst study in moderate osas patients were studied. high intensity and low intensity emst has advantages and disadvantages.the study aims to compare the effects of high (60% mep) and low (30% mep) expiratory muscle strength training (emst) on disease severity, sleep efficiency, snoring, fatigue severity and quality of life in severe osas patients.

ahi evren chest cardiovascular surgery training research hospital in sleep lab, polysomnography will be directed to the physiotherapist by the pulmonologist with severe osas patients. patients will be divided into two groups by block randomization method. the study was planned as double-blind. patients will not know what treatment they are receiving, the doctor does not know what treatment the patient is receiving, and technicians who take and analyze polysomnography will not know what treatment the patients are receiving. severe osas patients with mep 30% (low intensity) to the first group, mep 60% (high intensity) to the second group with expiratory muscle training device, 7 days / week, 25 breaths per day, 1 minute rest for 5 breaths will be run with the cycle. the training will take a total of 8 weeks. the follow-up of the patients will be done remotely by phone. mep measurements will be repeated every 2 weeks in the hospital and the new training workload will be calculated.

Eligibility criteria:
inclusion criteria: 1. patients diagnosed with severe osas by polysomnography in ahi evren chest, cardiovascular surgery training and research hospital sleep center will be included. 2. general health condition is stable exclusion criteria: 1. passed stroke, 2. neurological disease and psychological disease 3. cardiac disease 4. hypothyroidism 5. serious obstructive nasal disease, 6. a history of infection in the past month. 7. previous oroferengeal surgery history 8. with a bmi of 40 kg / m2 or more, 9. using substance, alcohol, sedative and hypnotic drugs

Keywords: expiratory muscle strength training snoring sleep quality emst
biofunctionalization of a volume-stable collagen matrix (vcmx) for the treatment of single gingival recession

Conditions: Gingival Recession

Summary: the treatment of single gingival recessions comprises different well-established techniques, and the association between coronally advanced flap (caf) and the subepithelial connective tissue graft is considered the gold standard. however, despite the excellent clinical results obtained, the use of subepithelial connective tissue graft is related to an increased risk of trans and postoperative bleeding, a longer duration of the surgical procedure and greater postoperative pain and morbidity. to overcome these limitations and increase patient acceptance, new biomaterials have been developed as possible alternatives to the use of connective tissue graft. recently, tissue engineering has been investigating collagen matrices as carriers of biologically active substances. in vitro and in vivo studies have shown that the biofunctionalization of these matrices using injectable platelet rich-fibrin (i-prf) can optimize the healing process of soft tissues using own's patient regenerative components. however, although it has promising potential, clinical studies evaluating the performance of functionalized collagen matrices are still scarce in the literature. thus, the present study aims to evaluate the clinical, esthetic, patient-centered, immuno and microbiological results of the use of the biofunctionalized volume stable collagen matrix (vcmx) for the treatment of single gingival recessions rt1. for such purpose, a randomized controlled clinical trial of superiority, parallel and blind will be carried out. seventy-five patients with rt1 single gingival recession will be selected, who will be randomly allocated to one of the following groups: caf+vcmx+i-prf (n = 25), coronally advanced flap associated with vcmx functionalized with i-prf; caf+vcmx (n=25), coronally advanced flap associated with vcmx; and caf group (n = 25), coronally advanced flap alone (caf). the groups will be compared regarding clinical, esthetic and patient-centered outcomes at the baseline, three and six months after the surgical procedure. the microbiological evaluation will be performed at baseline, three and six months after surgery and the concentration of inflammatory markers and growth factors will be assessed before the procedure and 3, 7, 14, 30 and 60 days after treatment.


Eligibility criteria:
inclusion criteria: * presence of rt1 (cairo et al., 2011) buccal single gingival recession (gr) on vital upper or lower canines and premolars with intact root surface (visible cej). * presence of dentin hypersensitivity (hd) and/or esthetic concerns related to gr. * adults \> 18 years old. * systemically health. * no signs of active periodontal disease. * full-mouth plaque and bleeding score ≤ 20%. * written informed consent given. exclusion criteria: * smoking. * contraindication for periodontal surgery. * pregnancy. * presence of orthodontic braces. * medications known to interfere with periodontal healing. * use of anticoagulants.

Keywords: platelet-rich fibrin gingival recession
intubation and ventilation skill training using modified peyton's four-step approach

Conditions: Educational Problems

Summary: endotracheal intubation and mask ventilation procedural skills are basic skills which have to be learnt by medical student and have to be practiced directly. however, during covid-19 pandemic, offline training was difficult to be conducted and new specific learning method has not established yet. the study aims to assess the effectiveness of modified peyton's four-step approach, which can be implemented through online training, compared to the classic peyton's four-step approach in learning endotracheal intubation and mask ventilation procedural skills.


Eligibility criteria:
inclusion criteria: * preclinical students of faculty of medicine universitas indonesia agreed to participate and signed the consent * preclinical students of faculty of medicine universitas indonesia registered to attend every training session of endotracheal intubation and mask ventilation under basic clinical skills module * 100% attendance in every session exclusion criteria: * students who have attended endotracheal intubation and mask ventilation training beforehand * students who have learnt endotracheal intubation and mask ventilation under basic clinical skills module beforehand drop out criteria: * preclinical students of faculty of medicine universitas indonesia who quit from basic clinical skills module during research * students who have never attended the training session