Kornimate/medical-research-clean huggingface dataset:
trends over time (1990-2010) of diarrhoea-related hospitalizations and deaths in children < 5 years of age in brazil

Conditions: Diarrhoea; Gastroenteritis

Summary: this study aims at collecting data to obtain baseline incidence and monitor trends over time in hospitalizations and deaths from all cause gastroenteritis in children \<5 years of age, before and after implementation of rotarix™ universal mass vaccination in brazil.

in this study baseline gastroenteritis related hospital discharges and mortality data from the ministry of health databases (datasus) will be compared to the current data after introduction of rotarix™.

Eligibility criteria:
inclusion criteria: * gastroenteritis associated hospital discharges and gastroenteritis related deaths occurring in children \<5 years of age during the period analyzed and registered in the datasus databases will be collected for the study exclusion criteria: * not applicable

Keywords: gastroenteritis
investigating the effects sacroiliac joint dysfunction on gait in individuals with back pain

Conditions: Biomechanical; Lesion

Summary: sacroiliac joint dysfunction (sjd) is a common problem in individuals with lumbar herniation nucleus pulposus (lhnp) plus back pain. it is important to determine the effects of sjd on the gait characteristics in individuals with lhnp.twelve individuals with lhnp (control group) and six individuals with lhnp plus sjd (study group) will be the participants of the study. gait characteristics of participants will be evaluate with treadmill. participants will walk at their self-selected speed for six minutes and data from 2nd minutes to 4th minutes were selected for statistical analyses. gait speed, cadance, step lengths, time on each foot and step length variabilities will be recorded.

sacroiliac joint dysfunction (sjd) is a common problem in individuals with lumbar herniation nucleus pulposus (lhnp) plus back pain. it is important to determine the effects of sjd on the gait characteristics in individuals with lhnp.twelve individuals with lhnp (control group) and six individuals with lhnp plus sjd (study group) will be the participants of the study. gait characteristics of participants will be evaluate with treadmill. participants will walk at their self-selected speed for six minutes and data from 2nd minutes to 4th minutes were selected for statistical analyses. gait speed, cadance, step lengths, time on each foot and step length variabilities will be record

Eligibility criteria:
inclusion criteria: have current back pain have lumbar disc herniation diagnosis have sacroiliac dysfunction exclusion criteria: do not want to participate have another systemic, neurologic or orthopedic problem

Keywords: biomechanical phenomenon gait lumbar disc degeneration
adult trauma centers re-aim at gun safety

Conditions: Firearm Injury; Safety Issues

Summary: the goal of this interventional study is to evaluate the implementation and effectiveness of a comprehensive a universal firearm injury prevention program, actfast (adopting comprehensive training for firearm safety in trauma centers), in level 1 trauma centers. the main aims of the study are: 1. (primary aim 1) increase the adoption, implementation, and maintenance of a universal firearm injury prevention intervention at three participating trauma centers in the mid-atlantic states; 2. (primary aim 2) assess firearm injury prevention knowledge, attitudes, and safe storage practices among trauma patients treated within participating trauma centers.


Eligibility criteria:
electronic medical record (emr) participants: inclusion criteria: * trauma patients admitted to adult trauma inpatient services at participating institutions exclusion criteria: * none patient participants inclusion criteria: * at least 18 years of age; * admitted to a participating trauma service for an injury; * fluent in english or spanish; * able to provide informed consent. exclusion criteria: * prisoner or in police custody; * admitted due to suicide attempt * any acute conditions that would preclude provision of informed consent or assent (i.e., acute psychosis, altered mental status, cognitive impairment). staff participants inclusion criteria: * trauma service physician, physician assistant, nurse practitioner, nurse or social worker at participating pediatric trauma center exclusion criteria: * none
nxstan: a culturally tailored intervention to prevent diabetes in american indian men

Conditions: Diabetes

Summary: to reduce modifiable diabetes risk factors' in overweight and obese ai men residing on the colville reservation through a community-based, culturally informed intervention, the study specifically aims to: 1. conduct focus groups and interviews with adult members of colville tribe to inform the adaptation, manualization and implementation of a culturally informed diabetes prevention program among overweight and obese ai men; 2. evaluate the effectiveness of a community-based, culturally informed diabetes prevention intervention by assessing between group changes.

to reduce modifiable diabetes risk factors' in overweight and obese ai men residing on the colville reservation through a community-based, culturally informed intervention, the study specifically aims to: 1. conduct focus groups and interviews with adult members of colville tribe to inform the adaptation, manualization and implementation of a culturally informed diabetes prevention program among overweight and obese ai men; 2. evaluate the effectiveness of a community-based, culturally informed diabetes prevention intervention by assessing between group changes in: primary outcomes: weight, dietary fat and caloric intake, vegetable consumption, and physical activity; secondary outcomes: physical fitness, blood pressure, lipids, self-reported quality of life; and, 3. evaluate the sustainability of the diabetes prevention intervention by assessing participant perceptions of program component fit through focus group discussions with participants in the intervention and telephone interviews with those who left the program.

Eligibility criteria:
inclusion criteria: * must be male and self-reported american indian; reside in or near colville tribe; ages 21-65, a bmi ≥25 kg/m2 and/or a waist circumference \>90 cm for men; no prior diabetes diagnosis; no history of heart disease, serious illness, cancer diagnosis in the last five years, or other conditions that may impede or prohibit participation; and, willingness to consent to randomization exclusion criteria: * females, under 18 years old or older than 65 years
mapracorat ophthalmic suspension, 3% for the treatment of ocular inflammation following cataract surgery

Conditions: Inflammation; Pain; Cataract

Summary: the objective of this study is to compare the safety and efficacy of mapracorat ophthalmic suspension, 3% to vehicle for the treatment of postoperative inflammation and pain following cataract surgery.


Eligibility criteria:
inclusion criteria: * subjects who are candidates for routine, uncomplicated cataract surgery. * subjects must be willing to wait to undergo cataract surgery on the fellow eye until after the study has been completed. exclusion criteria: * subjects who are expected to require treatment with any systemic or ocular (either eye) drugs specified in the protocol during the 18 days following cataract surgery or any systemic or ocular corticosteroids within 14 days prior to cataract surgery. * subjects who have known hypersensitivity or contraindication to the study drug(s) or their components. * subjects who have a severe/serious ocular condition or history/presence of chronic generalized systemic disease that the investigator feels might increase the risk to the subject or confound the result(s) of the study.
reliability of hammersmith examination in prediction of neurological outcomes (rehapeno)

Conditions: Child Development Disorders; Preterm Infant; Cerebral Palsy

Summary: in this study workers are trying to test the correlation between hammersmith infant neurological examination and mri brain/cranial ultrasound with early prediction of neurological developmental outcome of preterm neonates. this study is prospective cross-sectional collecting the data of patients according to daily standard medical practice

the primary aim of this study is to evaluate the neurobehavioural performance of infants born preterm using the hammersmith infant neurological examination (hine) in standard medical practice and compare it with the gold standard mri and ultrasound imagings. it would be possible to check do we need to use all the 3 examinations or hammersmith examination would be enough reliable predictor. secondary aim is to explore the relationships between mri brain /cranial us abnormalities and hine at term-equivalent age in infants born preterm in prediction of neurological outcome at 1 year of chronological age. this study will be only single arm/single group. this group would receive the regular practice of mri, ultrasound (us) and hammersmith assessments. the 3 assessments would be compared in relationships with the neonatal developmental outcomes (developmental milestones).

Eligibility criteria:
inclusion criteria: * preterm infants \<37 weeks' ga at birth admitted to the neonatal nurseries at the abha private hospital in kingdom of saudi arabia. this project aims to recruit 50 infants \<37weeks at birth over a 1-year stating from march 2018 exclusion criteria: * -infants with congenital or chromosomal abnormalities

Keywords: preterm child development disorders hammersmith neurological outcomes epidemiology
effects of pea-lut on frontal lobe functions and gabaergic transmission in long-covid patients

Conditions: Fatigue; Cognitive Deficit; COVID-19; Neurophysiologic Abnormality

Summary: the study explore the efficacy of pea-lut in patients suffering from neurological symptoms of long-covid

aim of this study was testing the possible therapeutic effects of an 8-week therapy with pea-lut on gabab-ergic neurotransmission, ltp-like synaptic plasticity, indexed with transient potentiation of motor evoked potentials (mep) amplitude after repetitive tms given as intermittent theta burst stimulation (itbs) in long covid patients with cognitive complaints and fatigue.

Eligibility criteria:
inclusion criteria: * previous diagnosis of sars-cov-2 infection confirmed through detection of virus rna by polymerase chain reaction (pcr) testing of a nasopharyngeal swab; * subsequent recovery from infection as defined by two consecutive negative pcr tests separated by at least a day; * mild form of covid-19 (symptoms may include fever, cough, sore throat, malaise, myalgia, anorexia, nausea, diarrhoea, anosmia and ageusia) without necessitating hospital admission; * complaints of cognitive difficulties and/or sense of fatigue, persisting after sars-cov-2 infection. exclusion criteria: * prior or concurrent diagnosis of neurological, psychiatric, endocrine, metabolic or cardiopulmonary conditions; * clinical and/or radiological evidence of covid-19 related pneumonia during the active phase of the disease; * anaemia; * current pharmacological treatment with corticosteroids, antihistamines, antihypertensives, diuretics, antidepressants, anxiolytic or hypnotic drugs at the time of study

Keywords: fatigue cognitive deficits post-covid19 syndrome
efficacy of potassium nitrate solution in reducing dentinal hypersensitivity

Conditions: Dentine Hypersensitivity

Summary: an exploratory study investigating the direct application of potassium nitrate (kno3) solutions of different concentrations in reducing dentine hypersensitivity.


Eligibility criteria:
inclusion criteria: * self-reported history of dentinal hypersensitivity lasting more than 6 months and a primary complaint of sensitive teeth * three teeth that can be isolated that meet all of the following criteria at the screening visit: * teeth showing signs of facial/cervical gingival recession and/or signs of erosion or abrasion. study teeth must exhibit greater than or equal to 3 mm recession at the facial surface midpoint * teeth must be visually stain and calculus free * teeth having a gingival index score of less than or equal to 2 * teeth with a clinical mobility less than or equal to 1 * teeth that show signs of sensitivity, evaporative (air) sensitive teeth displaying a response of greater than or equal to 30 mm on a 100 mm vas exclusion criteria: * chronic disease or other condition that is associated with intermittent episodes of constant daily pain, such as arthritis, low back pain, etc. * an condition or medication that causes xerostomia as determined by investigator * sensitive teeth not expected to respond to treatment with an over-the-counter dentifrice in the opinion of the investigator * teeth with exposed dentine but with deep, defective or facial restorations * teeth used as abutments for fixed or removable partial dentures * teeth with full crowns, orthodontic bands, extensive caries or cracked enamel * sensitive teeth with contributing etiologies other than erosion, abrasion or recession of exposed dentine. * dental prophylaxis within 3 weeks of the screening visit * tongue or lip piercing or presence of dental implants * subjects not using the same brand of toothpaste for at least 4 months prior to the screening visit * subjects who have used desensitizing toothpaste during the 4 weeks before treatment visit 1 * taking daily dose of medication which may interfere with the perception of pain. examples of such medications include analgesics, anticonvulsants, antihistamines that cause marked or moderate sedation, sedatives, tranquillizers, mood-altering drugs or anti-inflammatory drugs

Keywords: potassium nitrate tooth sensitivity dentin sensitivity
adjuvant sintilimab for locally advanced esophageal squamous cell carcinoma

Conditions: Esophageal Squamous Cell Carcinoma

Summary: no adjuvant treatment has been established for patients who remain at high risk for recurrence after neoadjuvant chemotherapy plus surgery and incidental pathologic lymph node metastasis following initial surgery for esophageal squamous cell carcinoma (escc).controversy still exists regarding the role of adjuvant immunotherapy for escc patients who do not achieve pcr after neoadjuvant chemotherapy plus surgery and clinical t1-2 n0 patients with incidental pathologic lymph node metastasis following initial surgery. to investigate the outcomes of adjuvant sintilimab in patients with locally advanced escc, we initiated this randomized controlled trial (rct).


Eligibility criteria:
inclusion criteria: 1. histologically proven squamous cell carcinoma. 2. tumours are located in the thoracic oesophagus. 3. age is between 18 years and 70 years. 4. ecog performance status of 0 or 1. 5. patients with resectable ct1-4an+m0 or t3-4an0m0 disease and residue disease is found after neoadjuvant chemotherapy plus surgery or ct1-2n0m0 and pathologically proven t1-2n+m0 after upfront surgery. 6. no metastatic cervical lymph nodes. 7. r0 resection is achieved by the minimally invasive esophagectomy (mie) or open mckeown approach with total two-field lymph nodes dissection or three-field lymph nodes dissection. 8. no prior therapy was administered against other cancers. 9. adequate bone marrow function: white blood cell count ≥ 4×109/l; absolute neutrophil count (anc) ≥ 1.5×109/l; platelets ≥ 100×109/l; haemoglobin ≥ 9 g/dl. 10. adequate liver function: serum bilirubin ≤ 1.5 × upper limit of normal (uln); aspartate transaminase (ast) and alanine transaminase (alt) ≤ 2.0 × uln (uln as per institutional standard). 11. adequate renal function: glomerular filtration rate ≥ 60 ml/min calculated using the cockcroft-gault formula. 12. normal thyroid function. 13. written consent is obtained. exclusion criteria: 1. patients receive neoadjuvant chemoradiation therapy. 2. patients with pathological complete response (pcr). 3. no. of lymph node dissection \< 15. 4. patients with clinical stages t1-2n+m0 and receive upfront surgery. 5. patients with unresectable disease (bulky metastatic lymph nodes or t4b) and receive induction chemotherapy. 6. patients requiring systemic steroid medication. 7. patients with severe postoperative complications and not suitable for adjuvant therapy. 8. synchronous or metachronous (within 5 years) double cancers. 9. patients ever received immunotherapy. 10. active infection requiring systemic therapy. 11. patients ever received organ transplant or allogenic haemopoietic stem cell transplantation. 12. patients with human immunodeficiency virus (hiv) infection. 13. psychiatric disease. 14. pregnant or lactating women or women of childbearing potential. 15. hypersensitivity for sintilimab.
measuring quality of life of versacryl relined dentures

Conditions: Denture Liners

Summary: resilient liners were introduced in the1950s and have been used since then as a gold standard material to increase the tolerance, retention and comfort of complete dentures. due to drawbacks of conventional resilient liners, their longevity is questionable and they require replacement which is time consuming and costly for the dentist and patient respectively. versacryl is a biocompatible intraoral thermo-elastic material. so versatile, it can be used to improve esthetics, retention and comfort for the patient. it softens with heat and when it is inserted to patient's mouth, it cools to body temperature providing desired rigidity. this process can be repeated many times to ensuring the comfort for the patient. versacryl has a reported predictable long term performance, durable bonding to acrylic denture bases, high fatigue endurance, excellent wear characteristics and solvent resistance with almost no free monomer in the processed material . the investigators' trial is done in order to improve the longevity and oral health related quality of life of soft liners in comparison to silicone-based soft liners.


Eligibility criteria:
inclusion criteria: 1. completely edentulous patients wearing complete dentures. 2. flat mandibular residual ridge. 3. mandibular denture indicated for relining. 4. patients with minimum of 2 years and maximum of 5 years complete denture usage. 5. angle's class i maxillary-mandibular relationship exclusion criteria: 1. drug or alcohol abuse. 2. inflammatory changes in the oral cavity. 3. candidiasis. 4. any intra-oral soft tissue hyperplasia. 5. physical reasons that could affect follow-up. 6. psychiatric problems. 7. heavy smokers. 8. dentures indicated for remake.
innovative stratification of arrhythmic risk (isar-trial): eldery

Conditions: Myocardial Infarction

Summary: the objective of this study was to determine the prognostic utility of established risk predictors following acute st elevation myocardial infarction in patients over 75 years of age.


Eligibility criteria:
inclusion criteria: acute myocardial infarction; aged \>75 years exclusion criteria: -

Keywords: assessment, risk autonomic nervous system aged
study of brain function in women with insulin resistant polycystic ovary syndrome

Conditions: Polycystic Ovary Syndrome

Summary: the purpose of this study is to evaluate the effects of insulin resistance on brain function in women with polycystic ovary syndrome (pcos). pcos affected women will be evaluated prior to and following 4-month treatment with metformin. additionally, brain function in women with pcos will be compared to the brain activity in normal control subjects with regular menstrual cycles.

the pathogenesis of polycystic ovary syndrome (pcos), a reproductive and metabolic disorder, is associated with insulin resistance. the effects of insulin resistance on cognition, mood, opioid system and reproductive function in pcos affected women are investigated in the current study. the identification of reversible changes in brain function and reproductive measures in insulin resistant pcos patients would likely significantly influence treatment protocols for these young women. 1. evaluate the differences in opioid tone in women with insulin resistant pcos compared to normal controls. 2. evaluate whether an oral hypoglycemic agent is capable of altering opioid tone in women with insulin resistant pcos.

Eligibility criteria:
inclusion criteria: * insulin-resistant pcos (arm: pcos affected women) * irregular menstrual cycle (arm: pcos affected women) * hyperandrogenism (arm: pcos affected women) * regular menstrual cycles (arm: normal controls) * normal hormonal levels (arm: normal controls) * lack of hirsutism (arm: normal controls) * acne-free (arm: normal controls) * candidates are bmi-matched and screened for insulin resistance prior to inclusion. (arm: normal controls) exclusion criteria: * left handedness * acute medical illness * uncorrected thyroid disease * diabetes renal * cardiac or pulmonary insufficiency * active liver disease * neurological disease * current psychiatric illness * claustrophobia * contraindications to mri * smoking * use of hormones * centrally acting or insulin sensitizing mediations * allergy to any opioid medication * substance abuse * pregnancy * bmi \>35.

Keywords: polycystic ovary syndrome insulin resistance metformin brain function
usg nerve blocks for acl reconstruction

Conditions: Pain, Postoperative

Summary: anterior cruciate ligament reconstruction is a routine surgical procedure. traditional femoral/sciatic block combinations effectively reduce postoperative pain, but results in considerable motor blockade. the investigators aimed to evaluate postoperative pain relief and the degree of motor block with block combinations of femoral nerve (fem) and obturator \[posterior branch\] nerve (onp), versus saphenous nerve (saph) and onp, versus placebo blocks with isotonic saline. all patients received standard patient controlled analgesia with morphine.randomized, placebo-controlled and double-blinded clinical trial. following irb approval, 81 patients were planned to be randomized to one of three usg block combinations: active fem+onp, active saph+onp or no active blocks (sham blocks) ropivacaine 0.75% was used for all active blocks following induction of general anaesthesia \[propofol-remifentanil, laryngeal mask airway\]. primary outcome measure: localized pacu pain scores (auc) 0-6 hours postoperatively at rest. secondary outcome measures: opioid consumption, opioid related side effects, pacu time, motor abilities of daily living scores \[modified barthel/100 index\], perceived ill health \[short form-8\] scores and degree of motor blockade \[jensen- børglum motor test\].


Eligibility criteria:
inclusion criteria: * age ≥ 18 years. * isolated primary acl reconstruction in general anaesthesia with hamstring graft. * asa 1-3. * written and informed consent to study protocol. exclusion criteria: * acl reconstruction with patellar tendon graft * uncooperative patients. * patients that do not understand or speak danish. * daily use of opioids equivalent to \> 40 mg morphine. * allergic to ropivacaine. * alcohol abusers * contraindications to general anaesthesia. * pregnancy.

Keywords: postoperative pain anterior cruciate ligament reconstruction ultrasound guided nerve blocks opioid consumption