Kornimate/medical-research-clean huggingface dataset:
the influence of deep tms on cerebellar signs in patients with machado joseph disease

Conditions: Machado Joseph Disease (SCA3)

Summary: to test the effects of low frequency deep rtms using the novel hcermjd-coil on cerebellar deficits in patients with sca3 and to establish its safety in this population. investigator is anticipate that stimulation of the cerebellum with the novel hcermjd-coil may induce significantly therapeutic effects in patients with sca3 and will pave the way for establishing a novel and effective treatment for this disorder.


Eligibility criteria:
inclusion criteria: * sca3 patients aged 20 - 80 years, with detectable clinical signs and confirmed genetic diagnosis. exclusion criteria: 1. patients who have concomitant epilepsy. 2. history of seizure or heat convulsion. 3. patients on neuroleptics. 4. patients with dementia (mmse\<25) or any unstable medical disorder. 5. history or current unstable hypertension. 6. history of head injury or neurosurgical interventions. 7. history of any metal in the head (outside the mouth). 8. known history of any metallic particles in the eye, implanted cardiac pacemaker, implanted neurostimulators, surgical clips (above the shoulder line) or any medical pumps. 9. history of frequent or severe headaches. 10. history of migraine. 11. history of hearing loss. 12. history of cochlear implants 13. history of drug abuse or alcoholism. 14. pregnancy or not using a reliable method of birth control. 15. participation in current clinical study or clinical study within 30 days prior to this study.

Keywords: machado joseph disease deep tms tms transcranial magnetic stimulation sca3 magnetic stimulation brainsway
effects of flourish hec and biogenesis to improve conception

Conditions: Infertility; Infertility Unexplained

Summary: this study intends to address whether improving the vaginal microbiome can help couples increase chances of conceiving.

disrupted vaginal microbiomes are associated with a number of poor reproductive outcomes, including infertility, miscarriage, premature rupture of membranes, preterm labor and delivery, delivery of a low birthweight baby, and maternal infections (chorioamnionitis, endometritis). a healthy vaginal microbiome is typically thought to be one that is dominated by one of several lactobacillus species, such as l. crispatus, l. gasseri, or l. jensenii. several studies have shown that non-lactobacilli-dominant biomes are associated with poor in vitro fertilization or intrauterine insemination outcomes. fewer studies have examined fertility in the home setting, and none to date has asked whether improving the vaginal microbiome (vmb) could increase fertility. this study addresses both. by assessing the vmb before and after using a vaginal care system which supports a healthy vmb, we will be able to examine whether there are associations between vmb composition and infertility, and whether shifting the vmb toward a lactobacillus-dominant state is able to improve chances of conception. in this study, women will either follow routine care (control) or routine care plus the vaginal care system and fertility lubricant (intervention) for 3 months or until becoming pregnant, whichever comes first. in addition to tracking conception rates during those 3 months, we will follow women for an additional year following completion of the 3-month timeframe. if any woman is pregnant at the one-year mark, her pregnancy will be followed until delivery (or early termination) to track delivery outcomes and adverse events.

Eligibility criteria:
inclusion criteria: women part of a cisgender couple aged 18 to 40 who are attempting to become pregnant and are attending a fertility clinic. exclusion criteria: 1. pregnant 2. lactating 3. severe male factor, hormonal imbalance (oligoovulatory/anovulatory cycles, cycles longer than 35 days), genetic abnormalities (chromosomal abnormality, common genetic mutation between partners), or severe uterine or tubal factor 4. any diagnosis that would require the participant to undergo in vitro fertilization to become pregnant 5. known allergies to any component of bionourish®, balance, biophresh®, or biogenesis™ 6. known active vaginal infection at enrollment
evaluation of drainable volume measurements during va-els

Conditions: Heart Arrest

Summary: veno-arterial extracorporeal life support (va-els) is used to support patients with acute cardiac failure. in that context, sufficient drainable venous volume is crucial for reliable and adequate support. to date, no reliable measurement method exists to monitor drainable volume adequately. furthermore, it is still unresolved how to diagnose adequate cardiac recovery. previous (pre)clinical studies showed that the calculation of the dynamic filling index may provide a valuable parameter to monitor the drainable volume in patients supported by vaels. in addition, a case report showed that measurement of the dynamic filling index could successfully be used to estimate cardiac recovery in a single patient supported by va-els in the icu. this study will assess the dynamic filling index as a representation for drainable volume and cardiac recovery using standard recorded perfusion data in patients supported by va-els


Eligibility criteria:
inclusion criteria: * written informed consent of the relative(s) or legal representative(s) * supported by va-els at the icu * \>18 years exclusion criteria: - pregnancy

Keywords: extracorporeal membrane oxygenation cardiopulmonary bypass
olanzapine versus midazolam for agitation

Conditions: Agitation,Psychomotor

Summary: the goal of this research investigation is to conduct a prospective observation of the comparative efficacy of midazolam versus olanzapine for the treatment of acute undifferentiated agitation in the emergency department.

the goal of this research investigation is to conduct a prospective observation of the comparative efficacy of midazolam versus olanzapine for the treatment of acute undifferentiated agitation in the emergency department. in the summer of 2017, the ed implemented a treatment protocol as a quality improvement initiative. the investigators performed observational research on this protocol and identified that haloperidol and ziprasidone were inferior to midazolam and olanzapine for treating agitation in our department. the comparison between olanzapine and midazolam, however, was inconclusive. it is possible that this is due to inadequate power, so the question of whether olanzapine or midazolam is superior is still unknown. because the department continues to strive to achieve the best care for this patient population, in the summer of 2018 the ed is going to initiate a second ed treatment protocol of olanzapine and midazolam, based on the results of our 2017 protocol. all patients requiring chemical sedation for will receive olanzapine as the initial treatment for agitation for 6 weeks, followed by midazolam as the initial treatment for agitation for 6 weeks. these patients will be observed by research staff. this is a clinical care quality improvement protocol. the clinical protocol is not research. the research component is the observation of this clinical care protocol.

Eligibility criteria:
inclusion criteria: * emergency department patients * patients 18 years and older * patients with acute undifferentiated agitation requiring chemical sedation at the discretion of the attending emergency physician will be observed. patients meeting these criteria who receive medications in the ed will be observed by research staff, evaluating efficacy and safety of the administered medication. exclusion criteria: - there are no exclusion criteria per se as this is only observational research. the decision to administer the medication is at the discretion of the physician. research protocols are only such that we are observing the efficacy and safety, which coincides the quality improvement purposes of this clinical protocol. patients will be provided an information sheet and can opt to have their data removed. patients who are prisoners, children, will not have their data collected
the diagnostic cut-off value of core biomarkers of alzheimer's disease

Conditions: Alzheimer's Disease

Summary: the participant in this study includes alzheimer's disease (ad including familial ad and sporadic ad) patients, amnestic mild cognitive impairment (amci) patients, non-ad dementia patients and cognitively normal control. the purpose of this study is to establish the best cut-off value of cerebrospinal fluid (csf) and blood β-amyloid (aβ) 42/40, total tau (t-tau) , phosphorylated tau ,inflammatory factors, etc. in diagnosis of alzheimer's disease (ad).

1. incorporating patients who meet the criteria from capital medical university xuanwu hospital including ad, amci, non-ad dementia and cognitively normal control. 2. collect the information of clinical and neuropsychological assessment (mini-mental state examination, mmse, montreal cognitive assessment, moca, and clinical dementia rating scale, cdr), neuroimaging data including medial temporal atrophy (mta) score, fazekas score, mri, and pet(optional), as well as the biological sample, such as csf and peripheral blood. 3. to quantify levels of aβ42, aβ40, t-tau, p-tau, inflammatory factors, etc. in csf and blood. 4. detect all participants apoe genotype. 5. independently establish the best cut-off value of chinese people in our laboratory. 6. analysis the relationships between core biomarkers in csf/blood and apoe genotype and neuroimaging data. 7. establish combined diagnostic model.

Eligibility criteria:
inclusion criteria: * aged 55-75. written informed consent obtained from participant or legal guardian prior to any study-related procedures. the diagnosis of ad is made using the national institute on aging and the alzheimer's association (nia-aa) criteria. the diagnosis of amci is assigned according to 2004 petersen criteria. as for non-ad dementia, the mckeith criteria are used for dlb, the revised diagnostic criteria proposed by the international bvftd criteria consortium for behavioral variant ftd, the gorno-tempini criteria for the semantic variant ftd or non-fluent aphasia, the movement disorder society task force criteria for pdd, the vascular behavioral and cognitive disorders (vas-cog) criteria for vad, the armstrong's criteria for cbd, the cdc's diagnostic criteria for cjd, etc. in addition, normal cognition is supported by mmse, cdr and other cognitive function scales. exclusion criteria: * other medical or psychiatric illness. no one can serve as an informant. refused to complete a cognitive test and provide biospecimen.

Keywords: alzheimer's disease
accuracy of handheld and non-contact tonometry

Conditions: Glaucoma; Intraocular Pressure; Glaucoma, Suspect

Summary: monitoring the intraocular pressure (iop) is one of the most important tests used in follow-up among glaucoma suspects and confirmed glaucomatous patients.

in tertiary hospitals, iop screening is an important tool to confirm glaucomatous eyes. inaccurate measurements may lead to missed diagnosis or false positive results that may affect patients' quality of life. there are many devices produced to measure iop, the commonest one is goldman contact tonometry, the aim of this study is to compare the results of new developed tonometers to the standard applanation tonometer.

Eligibility criteria:
inclusion criteria: * all subjects seeking regular check-up in glaucoma clinic at banha university hospital. * glaucoma suspects and glaucomatous patients that visit glaucoma clinic for regular iop measurements. exclusion criteria: * patients that will refuse to measure iop again with other devices. * patients with previous corneal surgeries or scar that may alter the measurements of the tonometer s (as previous keratoplasty, trauma or opacities).

Keywords: glaucoma suspect tonometer air-puff
effective volemia in older adults with orthostatic hypotension

Conditions: Orthostatic Hypotension

Summary: clinical and biological assessments of volemia are challenging in older patients as they are more likely to present non-typical signs. point of care ultrasonography (pocus) using heart and lung exploration is a relevant tool to assess volemia in adults with little data in older adults. the primary objective of the study is to evaluate feasibility of positional pocus in aging patients. the secondary objectives are to assess the variability of measurements between decubitus and sitting position.

this is a monocentric study. twenty patients will be enrolled, aged of 70 years and older. pocus parameters, duration of procedure and measurements will be recorded for each patients.

Eligibility criteria:
inclusion criteria: * 70 years and older * orthostatic hypotension or venous insufficiency * affiliated to a social security or beneficiary exclusion criteria: * refusal to participation to the study * cognitive disorder * unable to keep sitting posture for up to 30 minutes * foreign patients under french ame scheme

Keywords: older orthostatic hypotension volemia clinical sonography
effect of rocuronium on the acute hypoxic ventilatory response in patients with obstructive sleep apnea

Conditions: OSA; Rocuronium; Neuromuscular Blockade; Hypoxic Ventilatory Response; CPAP

Summary: this study describe the effect of partial neuromuscular blockade of rocuronium on the acute hypoxic ventilatory response in patients with osa before and after 3 month of cpap treatment.


Eligibility criteria:
inclusion criteria: * male with diagnosed moderate osa (ahi 15-30), untreated, but planned for cpap treatment. healthy except for osa and well controlled tablet treated hypertension where the treatment has not been changed during the last 3 month. none smokers. 18-70 years old. bmi \<35. exclusion criteria: * if they don´t fit the inclusion criteria
project cope (coping options for parent empowerment)

Conditions: Anxiety Disorders; Depression

Summary: the purpose of this research study is to collect information to better understand caregiver responses to covid-19 stress and to help caregivers of children with autism spectrum disorder (asd) cope with these stressors.


Eligibility criteria:
inclusion criteria: 1. must be willing to consent to participate via redcap 2. indicate a mild or greater elevation on screening measures of anxiety and/or depression 3. not meet any exclusion criteria. 4. lives in florida 5. has a child between the ages of 4-13 years who has been diagnosed with asd 6. speaks either english or spanish primarily 7. has technical capacity to participate in zoom sessions on a mobile device or preferably a computer exclusion criteria: 1. severe mental illness (e.g., bipolar disorder, schizophrenia, an intellectual disability, psychosis, alcohol use disorder, substance use disorder) or hospitalization for mental health concerns or suicide attempt. parents may receive concurrent psychiatric or psychological intervention services but may be excluded if the severity of current mental illness is such that outpatient, weekly group treatment would be considered inappropriate. 2. parents who report any prior arrest for child endangerment, child abuse or child neglect may also be excluded. 3. parents who have moderate or greater risk of suicidal ideation.
heart patch for myocardial infarction covid-19

Conditions: Myocardial Infarction; Heart Diseases

Summary: myocardial infarction (mi), as one of the many complications of covid-19, is one of the contributing patients of patients' death. this study attempts on developing an intervention of mi by regenerating damaged cardiomyocytes due to insufficiency of oxygen in cardiac muscles, triggered by an occlusion of coronary artery (mi). heart patch developed from amnion bilayer seeded with amnion epithelial stem cells and patient's autologous cardiomyocytes is used as a therapy. patients who undergo bypass (cabg) surgery are given heart patch, and then patients condition are observed by ecg, echo, blood test, and radiology (technetium-99m)


Eligibility criteria:
inclusion criteria: * aged 40 - 60 years old * ischemic burden \>10% and ischemic gradients red-violet * ischemic area is not feasible to be grafted (bypass) due to other conditions such as diffusion and deep intramuscular vascularization * ejection fraction \>30-35% * euro score \<8 exclusion criteria: * scanning of technetium-99 showed black colored ischemic area * patients undergoing other procedures other than bypass such as valve repair * chronic kidney failure * patients have went through several bypass surgeries prior * patients are still covid-19 positive * immunocompromised patients
a study to evaluate the effects of itraconazole on mk-1708 in healthy participants (mk-1708-003)

Conditions: Alzheimer's Disease

Summary: the goal of the study is to see what happens to levels of mk-1708 a person's body over time. researchers will compare what happens to mk-1708 in the body when it is given with or without a medicine called itraconazole.


Eligibility criteria:
inclusion criteria: the key inclusion criteria include but are not limited to the following: * is in good health before randomization * has a body mass index (bmi) ≥18.5 and ≤32 kg/m\^2, inclusive exclusion criteria: the key exclusion criteria include but are not limited to the following: * has a history of clinically significant endocrine, gastrointestinal (gi), cardiovascular, hematological, hepatic, immunological, renal, respiratory, genitourinary, or major neurological (including stroke and chronic seizures) abnormalities or diseases * has a history of cancer
patient and caregiver priorities in neuro-oncology care

Conditions: Malignant Central Nervous System Neoplasm; Metastatic Malignant Neoplasm in the Central Nervous System

Summary: this study is being done to identify patient and caregiver burdens regarding their experience with diagnosis and treatment of cns tumors. these results will help doctors find areas where patients and caregivers may need more support.

primary objectives: i. describe the patient experience and characterize the symptom burden related to primary or metastatic central nervous system tumors. ii. describe the caregiver experience and caregiver needs related to patients with primary or metastatic central nervous system tumors. iii. establish which interventional treatment outcomes are important to patients and caregivers, within a wider understanding of their lived experience with cns tumors and their treatment. outline: this is an observational study. patients and their caregivers participate in interviews on study. patients also have their medical records reviewed on study.

Eligibility criteria:
inclusion criteria: * \* age ≥ 18 years. * diagnosis of primary or metastatic cns tumor with a primary caregiver, should patient wish to involve one. * willing and able to participate in a semi-structured interview lasting approximately 60 minutes. dyad interviews conducted for participants who elect to involve a caregiver. * willing and able to participate in a single follow-up interview. dyad follow up interviews conducted for participants who elect to involve a caregiver. exclusion criteria: * \* uncontrolled and/or intercurrent illness which limits participation in study interview. * vulnerable populations: pregnant or nursing persons, prisoners, or persons lacking capacity for understanding. * unable to read and speak english. * note: english does not need to be primary language.
myofascial trigger points in the upper limb in stroke patients

Conditions: Stroke

Summary: one source of shoulder pain can be myofascial trigger points (mtrps). mtrps are localized, hyperirritable points in the skeletal muscles that are associated with palpable nodules in muscle fibres. mtrps can be classified into active and latent. latent mtrps demonstrate the same clinical characteristics as active mtrps but they do not provoke spontaneous pain. numerous studies have shown that mtrps are prevalent in patients with chronic non-traumatic neck and shoulder pain.


Eligibility criteria:
inclusion criteria: * unilateral shoulder pain and a physician-diagnosed stroke. exclusion criteria: * rheumatic inflammatory, * systemic diseases, * acute traumatic conditions, * postoperative conditions, neck and elbow disorders, and * serious aphasias in which there was a communication problem.

Keywords: stroke pain shoulder
effect of transcutaneous electroacupuncture on functional abdominal bloating/distension

Conditions: Functional Abdominal Bloating/Distension

Summary: functional abdominal bloating/distension (fab/d) is a common functional bowel disorder that lacks effective treatment options. transcutaneous electroacupuncture (tea) as a new therapeutic method has great effect on functional gastrointestinal diseases such as functional dyspepsia and functional constipation. research on tea for fab/d has not yet been explored.

functional abdominal bloating/distension (fab/d) is a common functional bowel disorder that lacks effective treatment options. rome iv was introduced in 2016. studies have shown that bloating may affect about 30% general population and 96% of patients with functional gastrointestinal disorders (fgid).transcutaneous electroacupuncture (tea) as a new therapeutic method has great effect on functional gastrointestinal diseases such as functional dyspepsia and functional constipation. research on tea for fab/d has not yet been explored. thirty patients who fulfilled the rome iv diagnostic criteria of fab/d in the department of the second affiliated hospital of xi'an jiaotong university.inclusion criteria included: symptoms of recurrent abdominal fullness, pressure, or a sensation of trapped gas (bloating), and/or measurable (objective) increase in abdominal girth (distention) more than 6 month；the main symptoms appeared in the past 3 months；not taking related drugs; aged 18-65 years old；from january 2020 to december 2021; sign informed consent. all patients were randomly assigned to 3 groups and received tea at zusanli (st36) and neiguan (pc6) with 3 diffrent parameter for 4weeks. the symptom severity score, abdominal girth, electrogastrogram (ecg) and orocecal transit time (octt) ,heart rate variability (hrv) ,rectal sensitivity and intestinal flora were recorded at baseline and after 2-week treatment, respectively. the symptom severity score was repeated at baseline and after 4-week treatment. through the comparison of the index before and after tea treatment to identify optimal stimulation parameters and explore its possible mechanism. the study was proved by the medical ethics committee of the second affiliated hospital of xi'an jiaotong university.

Eligibility criteria:
inclusion criteria: 1. clinical diagnosis of functional bloating/distension with rome iv; 2. aged 18-65 years old； exclusion criteria: 1. have taken drugs that may affect gastrointestinal motility in the past week; 2. have taken antibiotics and probiotics in the past month; 3. the history of gastrointestinal surgery; 4. helicobacter pylori is not cleared； 5. pregnant and breastfeeding women; 6. skin allergies.

Keywords: functional bloating/distension transcutaneous electrical acupoint stimulation