Kornimate/medical-research-clean huggingface dataset:
long-term outcomes and prognostic factors in patient undergoing cabg or pci

Conditions: Ischemic Heart Disease

Summary: 1. to evaluate the long-term clinical outcomes and prognostic factors in patients with coronary artery disease undergoing coronary artery bypass graft surgery. 2. to evaluate the long-term clinical outcomes and prognostic factors in patients with coronary artery disease undergoing percutaneous coronary intervention with drug-eluting stent.

coronary artery disease (cad) still remains one of the world's leading causes of death, despite markedly improvement of devices and technologies on past several decades. the treatment strategy for cad included medical treatment, percutaneous coronary intervention (pci), and coronary-artery bypass grafting (cabg). cabg is a procedure in which autologous arteries or veins are used as grafts to bypass coronary arteries that are partially or completely obstructed by atherosclerotic plaque. during the past decade, there has been nearly a 30% decline in cabg procedures, despite abundant evidence to support the effectiveness and safety of the operation.this decline has been accompanied by a corresponding increase in pci. to date, there have been numerous studies to compare the clinical outcomes between pci and cabg for patients with cad. among them, syntax (synergy between pci with taxus and cardiac surgery) trial demonstrated cabg is associated with lower incidence of major adverse cardiac and cerebrovascualr events in patients with high syntax score, compared with pci. in this regard, the current guidelines recommend that cabg is preferred method for care of stable ischemic heart disease patients with three-vessel or left main coronary artery disease. however, most randomized controlled studies do not reflect the contemporary practice, because they have been performed in the era of bare metal stents or first-generation drug-eluting stent (des). in addition, there have been limited data regarding the prognostic factors for long-term clinical outcomes in patients undergoing pci with des or cabg. therefore, the investigators sought to compare the clinical outcomes between pci with des or cabg, and to identify prognostic factors for long-term clinical outcomes in patients who underwent pci with des or cabg.

Eligibility criteria:
inclusion criteria: * patients who suspected ischemic heart disease and underwent cabg or pci with des exclusion criteria: * age \< 18 years

Keywords: ischemic heart disease coronary artery bypass grafting percutaneous coronary intervention
a study to evaluate the effectiveness and safety of 5 percent minoxidil foam in the treatment of male pattern hair loss

Conditions: Androgenetic Alopecia

Summary: the primary purpose of the study is to evaluate the efficacy of a topical 5% minoxidil formulation in males for the treatment of pattern hair loss. the secondary purpose is to evaluate the safety of a topical 5% minoxidil formulation in males when used twice daily for the treatment of pattern hair loss and to obtain the safety data on the investigational product when used twice daily for up to one year.

male subjects with androgenetic alopecia were enrolled in this fourteen-center trial. subjects were randomized to use either 5% minoxidil or placebo foam twice daily for 16 weeks. a total of 143 subjects continued use of the 5% minoxidil foam for 8 to 12 months in an open-label phase to obtain safety data on 5% minoxidil topical foam when used twice daily for up to one year. the 5% minoxidil foam was shown to be effective in the treatment of male androgenetic alopecia in a 16 week trial. it was statistically significantly superior to placebo foam in the primary efficacy measure of mean change in the non-vellus hair count in the target region between baseline and week 16, and the subject rating assessed an overall improvement from baseline. the efficacy of 5% minoxidil compared to placebo was confirmed by the secondary efficacy endpoints of scores from the expert panel review of hair regrowth when comparing photographs obtained at baseline with photographs obtained at week 16, as well as the percent change from baseline in non-vellus hair counts within a pre-specified area of clipped hair. the 5% minoxidil foam formulation was well tolerated, the incidence of adverse events was similar between groups, and no safety concerns were raised based on clinical laboratory test results, vital signs or scalp irritation scores.

Eligibility criteria:
inclusion criteria: * presence of androgenetic alopecia with vertex pattern iiiv, iv, or v on the norwood hamilton scale * male sex, age 15 to 49, good health * willingness to have a dot tattoo placed in the target area of the scalp during the study * willingness to maintain normal shampooing habits and products during the study * willingness to maintain the same hair style, approximate length, and hair color throughout the study exclusion criteria: * known sensitivity to the investigational product

Keywords: alopecia, balding
the use of evicel to reduce blood loss in total knee replacement surgery

Conditions: Osteoarthritis

Summary: application of "evicel" hemostatic matrix during operation for unilateral total knee replacement surgery (tka) will result in decreased bleeding and postoperative drain output, a reduction in transfusion requirements, and less reduction of hemoglobin.

no additional data desired

Eligibility criteria:
inclusion criteria: - diagnosis of degenerative joint disease of the knee in patients medically suitable to undergo unilateral total knee arthroplasty exclusion criteria: * known allergies to human blood products. * history of bleeding disorders. * patients with previous arthrotomy, however, with exception of medial or lateral menisectomy. * patients taking lovenox, plavix, aggrenox or erythropoetin. (coumadin is acceptable) * additionally, any patient with an intra-operative complication (i.e bone fracture, vascular injury) or post-operative complication that would affect bleeding tendency will be excluded although data will be recorded for later analysis. also, any patient who has a complication with the suction drain (eg inadvertently being pulled out, suction failing) will have the remaining data points recorded and drain measurements will be excluded from analysis.

Keywords: osteoarthritis total knee replacement
systematic follow up of second line treatments for parkinson's disease (deep brain stimulation, apomorphin pump, duodopa pump)

Conditions: Parkinson's Disease

Summary: primary purpose: fluctuations and dyskinesia evolution in parkinson's disease patients, one year after initiation of deep brain stimulation, apomorphin pump or duodopa pump secundary purposes: * motor complications evolution at 6 months, 2 and 3 years * mds updrs iii score at 6 months, 1, 2 and 3 years * non motor complications evolution at 6 months, 1, 2 and 3 years * cognition and psychiatric complications evolution at 6 months, 1, 2 and 3 years * cutaneous and digestive complications at 6 months, 1, 2 and 3 years * neuropathy occurrence at 6 months, 1, 2 and 3 years * medical treatment and levodopa equivalent dose modifications at 6 months, 1, 2 and 3 years


Eligibility criteria:
inclusion criteria: * parkinson disease (ukpdssb criteria) * patient with fluctuations and/or dyskinesia , who need treatment with deep brain stimulation, apomorphin pump or duodopa pump * moca \>20 * patient \>21 years of age * patient who has signed protocol acceptation exclusion criteria: * patient who did not give his acceptation for the protocol * patient with another parkinsonian syndrome than parkinson' s disease * moca\<20 * patient who does not need second line treatment
the application value of intercostal suturing in preventing postoperative thoracoscopic lung resection chest wall pulmonary hernia

Conditions: VATS; Lung Hernia

Summary: the purpose of this trial is to understand whether intercostal suture can effectively prevent postoperative chest wall lung herniation, mainly to verify the following questions can intercostal suture reduce postoperative chest wall lung herniation the hemostatic effect and hemostatic time of intercostal suture on intercostal muscle incision bleeding during surgery the researchers will divide the participants into two groups, one group will receive intercostal suture, and the other group will not receive intercostal suture, that is, conventional suture the participants will receive or not receive intercostal suture during surgery hemostatic effect and hemostasis time of rib intermuscular incision bleeding during surgery chest ct will be reviewed 3 months after surgery to observe the chest wall incision


Eligibility criteria:
inclusion criteria: * patients undergoing lung resection via multiport thoracoscopic surgery:the intercostal muscles at the main incision site need to be dissected using an electrocautery knife.intercostal incisions should be used with a retractor and an incision protector to prevent damage to intercostal nerves and blood vessels,as well as rib fractures. age greater than or equal to 18 years no history of thoracic surgery exclusion criteria: * during the operation,if a patient's multiport thoracoscopic surgery needs to be converted to a thoracoscopic-assisted mini-thoracotomy,a rib retractor becomes necessary. during the operation,conversion to thoracotomy or a conventional posterolateral incision may be necessary based on the specific intraoperative circumstances. uniportal thoracoscopic surgery history of ipsilateral thoracic surgery

Keywords: lung hernia vats
a study in the treatment of acute mania

Conditions: Bipolar Disorder

Summary: the purpose of this study is to test the efficacy and total costs of olanzapine versus commonly used conventional antipsychotics in sweden.

the primary objective is to show that the efficacy of olanzapine is non-inferior to the conventional antipsychotics haloperidol or zuclopentixol in the treatment of an acute manic or mixed episode of bipolar disorder. efficacy is defined as time to remission, as measured by the total scores of the young mania rating scale (y-mrs), madrs-s, and clinical global impression - bipolar (cgi-bp). time from baseline to remission is defined as the primary efficacy measure. remission is defined as a y-mrs score \<=12 and a madrs-s score \<=12 and cgi-bp = 1 or 2. secondary efficacy assessments will include time from baseline to * response, as defined as a reduction of y-mrs score greater than or equal to 50% compared to baseline * relapse of mania, as defined as a y-mrs score \>= 16 and cgi-bp \>2 after having met the criteria for remission * switch into depression, as defined as a madrs-s score \>=17 and fulfilled criteria for major depression as self-assessed by dsrs.

Eligibility criteria:
inclusion criteria: * diagnosis of bipolar i disorder and currently display an acute manic or mixed episode (with or without psychotic features) * patients must have a y-mrs total score of greater or equal to 20 at visit 2 * patients must have experienced at least one manic or mixed episode prior to study enrollment * female of childbearing potential must be using a medically accepted means of contraception, or practice sexual abstinence * each patient must have a level of understanding sufficient to communicate intelligently with study personnel * patients must be considered reliable * each patient must understand the nature of the study and signed informed consent exclusion criteria: * female patients who are pregnant or lactating * serious, unstable illnesses such that hospitalization for the disease is anticipated within 3 month or death is anticipated within 3 years * uncorrected hypothyroidism or hyperthyroidism * narrow-angle glaucoma * history of allergic reactions or intolerance to study medications * dsm-iv substance dependence within the past 30 days at the judgement of the investigator * judged clinically to be at serious suicidal risk * treatment with an injectable depot neuroleptic within less than one dosing interval between depot neuroleptic injections prior to visit 2 * any patient treated with clozapine within 4 weeks prior to visit 2 * subjects who have received treatment with ect within one month prior to visit 1
a predictive technology for prevention of diabetic foot ulcers

Conditions: Diabetic Foot Ulcer

Summary: the dapshealth system employs a predictive technology for prevention of diabetic foot ulcers, and in real time, identifies diabetic patients who experience lower extremity trauma and vascular obstruction utilizing the science of temperature trending.

diabetes has become a major health issue in the united states and globally, particularly among older populations. there are currently 400 million diabetics worldwide, with 30 million diagnosed diabetics living in the us. the standard of care today in treating complications of diabetes is a reactive one: doctors often wait for a problem to occur and then treat it. this waiting approach results in high medical expenses and an increase in pain for patients. this study is testing a predictive technology system (investigational bluetooth-enabled thermometer and mobile app) to see if it can identify potential foot complications before the damage becomes irreversible. the thermometer being used in this study is the exergen dermatemp (dt) thermometer. participants will check the temperature of each foot daily for a period of three months. these results will sync directly from the thermometer to the mobile app. patients are notified when temperature levels indicate a potential complication that may lead to a developing foot ulcer. the study doctor is available to determine if any trauma or vascular obstruction has occurred and will follow up with the participant.

Eligibility criteria:
inclusion criteria: * diagnosis of diabetes * ambulatory * smart device exclusion criteria: * non-ambulatory * no smart device

Keywords: dfu
safety and efficacy of olopatadine 0.6% and azelastine 137 mcg in vasomotor rhinitis

Conditions: Vasomotor Rhinitis

Summary: the purpose of this study is to examine safety and efficacy of patanase and astelin in treating the symptoms of non-allergic vasomotor rhinitis (vmr).


Eligibility criteria:
inclusion criteria: * diagnosis of vmr with at least 2 years of chronic non-allergic rhinitis * negative skin tests to a panel of allergens and positive histamine test within last 2 years * history of symptoms related to defined vmr triggers exclusion criteria: * nasal disorder, surgery, or concurrent disease that could interfere with evaluation of study medications * bacterial or viral infection within 14 days of first visit. diagnosis of acute sinusitis within 30 days of first visit * chronic use of drugs that can cause rhinitis

Keywords: vasomotor rhinitis chronic non-allergic rhinitis vmr
a multi-center study on human microecology assisted diagnosis of colorectal cancer

Conditions: Human Microecology；Colorectal Disease；Auxiliary Diagnosis

Summary: as for this research，we want to find whether the intestinal microecology (flora, peptidoglycan fragments) have certain distribution characteristics in colorectal diseases; whether it can predict the development of disease/as a prognostic indicator.

we even want to find whether it can predict the development of disease/as a prognostic indicator.

Eligibility criteria:
inclusion criteria: * people who is going to get the colonoscopy examination exclusion criteria: * people who was diagnosed as one cancer，expect for crc; who has had the antibiotics or the medicine that treats for colorectal disease, except for medical probiotics, in one month; who has had the laxative and the colonscopy in one week; who had a operation in three month.
insulin sensitivity and substrate metabolism before and after treatment in patients with growth hormone deficiency

Conditions: Growth Hormone Deficiency

Summary: the purpose of this study is to further characterize the treatment related changes in insulin sensitivity, substrate metabolism and intrahepatic-intramyocellular lipids in patients with growth hormone deficiency (ghd).


Eligibility criteria:
inclusion criteria: * written informed consent * must be of legal age and competent * age: \>18 and \<60 years old * presently diagnosed with growth hormone deficiency; if panhypopituitary, the patient must be sufficiently substituted in the other axis´s, for at least 3 months before inclusion in the study exclusion criteria: * alcohol consumption \>21 units per week * malignant disease * pregnancy * magnetic implants or material in the body * claustrophobia * bmi \>30 * heart disease (nyha \>2) * uncontrolled hypertension * manifest diabetes mellitus * change in medication, with any influence on glucose metabolism, 2 months prior to and until the end of the trial. controls are matched on age, gender and bmi inclusion criteria: * written informed consent * must be of legal age and competent exclusion criteria: * alcohol consumption \>21 units per week * malignant disease * pregnancy * magnetic implants or material in the body * claustrophobia * heart disease (nyha \>2) * uncontrolled hypertension * manifest diabetes mellitus * change in medication, with any influence on glucose metabolism, 2 months prior to and until the end of the trial

Keywords: insulin sensitivity substrate metabolism fatty liver intramyocellular lipids growth hormone deficiency growth hormone deficiency (adult)
expanded evaluation of the survivorship wellness group program in the context of covid-19 and telehealth

Conditions: COVID-19 Infection; Hematopoietic and Lymphoid Cell Neoplasm; Malignant Solid Neoplasm

Summary: this study evaluates the effects of the survivorship wellness group program following active treatment, as well as to learn from survivorship wellness participants about their concerns regarding the current covid-19 pandemic. this study may help to evaluate the impact of the survivorship program on patient well-being, provide evidence for use in grant application and publications, and ultimately inform the continued improvement of survivorship care.

primary objectives: 1. to examine the feasibility and acceptability of implementing an interdisciplinary goal-setting clinical group program focused on domains of physical, psychological, and spiritual wellness for survivors of cancer at university of california san francisco (ucsf). 2. to determine preliminary efficacy of the survivorship wellness intervention in regards to: 1. increasing knowledge of and perceived confidence in execution of health behavior changes in domains of physical, emotional, and spiritual wellness for survivors of cancer. 2. increasing quality of life. 3. reducing symptoms of depression and anxiety. 4. increasing physical activity. 3. to assess differences in patient wellbeing and in the impact of the survivorship wellness program during the period of covid-19 and telehealth classes. outline: patients complete surveys over 5-10 minutes at baseline (i.e. before participating in the program), and at 9 and 15 weeks follow up on the impact of covid-19 on survivorship. patients also complete a survey assessing how patients rate telehealth classes in the survivorship wellness program.

Eligibility criteria:
inclusion criteria: * english-speaking * treated for any kind of cancer at ucsf, though finished with active treatments (defined as chemotherapy, radiation, or surgery) at time of enrollment, and without evidence of current active cancer * sufficient cognitive ability to participate in group activities as determined by their attending medical oncologist or surgeon exclusion criteria: * non-english speaking * primary cancer treatment outside of ucsf * currently receiving non-maintenance therapies (chemotherapy or radiation) for active cancer * psychiatric illness that would affect the ability to participate in a group activity

Keywords: covid-19 cancer survivorship
effects of benzocaine 20% topical anesthetic and no topical agent on pain perception during intra-oral injections

Conditions: Anesthesia

Summary: the aim of this randomized controlled trial. is to test the efficacy of topical anesthesia against the use of no topical agent during buccal infiltration in maxillary anterior teeth. the rationale behind this comparison is to evaluate the practical, clinical outcome of not using any topical agent if in fact topical anesthesia does not reduce pain as reported by various studies and if consequently its usage was to be discontinued.

the clinical implication of topical anesthesia and placebo being the same is to not use either of them prior to la administration in dentistry. this clinical approach has rarely been studied and this study aims to compare the effects of the use of topical anesthesia against the use of no topical agent prior to buccal infiltration in maxillary anterior teeth.

Eligibility criteria:
inclusion criteria: * above the age of 18 * males and females both * participants requiring extraction of maxillary anterior teeth * intact or minimally restored anterior teeth * patients with american society of anesthesiologists physical status of 1 or 2 exclusion criteria: * participants with physical american society of anesthesiologists physical status of 3 or 4 * showing signs of inflammation in the area to be injected * having known allergy to any of the agents used in the study * used anti- anxiety drugs or sedatives in the past two weeks * have taken analgesics on the day of data collection

Keywords: pain, benzocaine, clinical trial
nurse led follow-up after total knee arthroplasty

Conditions: Osteoarthritis

Summary: the aim of this study is to determine the effect of nurse led follow-up following total knee arthroplasty in regard to physical function, health related quality of life and self-efficacy.

due to shorter hospitalization the patients early have to be responsible for their own rehabilitation. however, the patients experience a variety of health related problems in the rehabilitations period following total knee arthroplasty and they have difficulties transferring health related information to their home settings. nurse led follow-up in the early rehabilitation period might improve the health status of the patients by improving their knowledge and skills to handle health related problems. no studies found has investigated the effect of nurse led follow-up in form of telephone call following total knee arthroplasty.

Eligibility criteria:
inclusion criteria: * primary first-time total knee arthroplasty due to osteoarthrosis * followed conventional admission course and discharged ≤ 4 days after surgery * understand and talk danish * signed informed consent exclusion criteria: * in terminal phase of another serious illness such as i.e. cancer with expected lifetime less than 6 months * previous total hip replacement

Keywords: total knee arthroplasty telephone follow-up physical function health related quality of life self-efficacy