Kornimate/medical-research-clean huggingface dataset:
sfdi in high energy lower extremity fracture

Conditions: Trauma Injury

Summary: this is a non-randomized prospective study of 20 patients with high energy lower extremity fractures evaluating feasibility and acceptability of sfdi, a real-time optical imaging technology.


Eligibility criteria:
inclusion criteria: * age 18 years or older * high energy lower extremity fracture * provision of informed consent exclusion criteria: * upper extremity fracture * metatarsal fractures

Keywords: trauma orthopaedic lower extremity
profile of covid-19 patients related to fatigue

Conditions: COVID-19

Summary: more than half of recovered covid-19 patients experience fatigue. studies are needed to define the profile of these patients. the objective of this study is to evaluate the profile of surviving patients of covid-19 in relation to fatigue.

background: more than half of recovered covid-19 patients experience fatigue. studies are needed to define the profile of these patients. objectives: evaluate the profile of surviving patients of covid-19 in relation to fatigue; methodology: observational study. the profile of the survivors of covid-19 will be described, dividing them into 2 groups based on the presence or absence of fatigue. patients will be recruited from the virgen de las nieves university hospital in granada. the evaluation will be carried out through google forms, telematic means or face-to-face depending on the variables. a symptomatic evaluation of fatigue, aspects related to fatigue and physical performance will be carried out.

Eligibility criteria:
inclusion criteria: * diagnosis of covid-19 * adults (\>18 years) * basic knowledge and access to the internet * wish to participate in the study and sign the informed consent exclusion criteria: * patients with severe comorbidities that interfere with the ability to perform the study, and those with mental, physical or organic problems that under medical criteria may pose a risk to the patient

Keywords: covid-19 fatigue
mdma-assisted cbt for ocd (mdma-cbt4ocd study)

Conditions: Obsessive-Compulsive Disorder

Summary: the study assesses the safety and preliminary effectiveness of mdma-assisted cognitive behavioral therapy in participants diagnosed with obsessive-compulsive disorder (ocd).

obsessive-compulsive disorder (ocd) is a chronic and disabling disorder that costs the economy over $2 billion annually and represents a significant public health problem. the proposed projects tests whether 3,4-methylenedioxymethamphetamine (mdma) reduces ocd symptoms.

Eligibility criteria:
inclusion criteria: 1. at least 18 years old 2. fluent in speaking and reading the predominantly used or recognized language of the study site 3. able to swallow pills 4. meet the criteria for ocd diagnosis 5. ybocs total score of at least 16 6. not on psychotropic medications 1 month prior to study enrollment 7. able to tolerate a treatment-free period 8. able to tolerate study procedures 9. failed at least 1 prior trial of standard first-line ocd treatment 10. agree to the following lifestyle modifications: comply with requirements for fasting and refraining from certain medications prior to the experimental session, not enroll in any other interventional clinical trials during the duration of the study, and commit to medication dosing, therapy, and study procedures. exclusion criteria: 1. pregnant or nursing, or able to become pregnant and are not practicing an effective means of birth control 2. weigh less than 48 kilograms (kgs) 3. any current problem which, in the opinion of the investigator or study physician, might interfere with participation

Keywords: ocd mdma ocd cbt cognitive behavioral therapy
a study to evaluate raptiva in adults with moderate to severe plaque psoriasis who are candidates for systemic therapy

Conditions: Psoriasis

Summary: this is a phase iiib, randomized, double-blind, parallel-group, placebo-controlled, multicenter study designed to evaluate the safety and tolerability of efalizumab administered subcutaneously at weekly doses of 1.0 mg/kg in subjects with moderate to severe plaque psoriasis who are candidates for systemic therapy.


Eligibility criteria:
inclusion criteria: * signed informed consent * plaque psoriasis covering \>=10% of total bsa * diagnosis of plaque psoriasis for at least 6 months * minimal pasi score of 12.0 at screening * in the opinion of the investigator, candidate for systemic therapy for psoriasis who has not been previously treated (naive to systemic treatment) or prior treatment with systemic therapy for psoriasis (e.g., puva, cyclosporine, corticosteroids, methotrexate, oral retinoids, mmf, thioguanine, hydroxyurea, sirolimus, azathioprine, 6-mp, etanercept) * body weight of \<=140 kg * 18 to 75 years old * for women of childbearing potential, willingness to use an acceptable method of contraception to prevent pregnancy for the duration of the study * willingness to hold sun exposure reasonably constant and to avoid use of tanning booths or other uv light sources during the study * willingness to enter study acd2601g exclusion criteria: * guttate, erythrodermic, or pustular psoriasis as sole or predominant form of psoriasis * history of severe allergic or anaphylactic reactions to humanized monoclonal antibodies or fusion proteins that contain an ig fc region * clinically significant psoriasis flare during screening or on the day of randomization * history of or ongoing uncontrolled bacterial, viral, fungal, or atypical mycobacterial infection * history of opportunistic infections (e.g., systemic fungal infections, parasites) * seropositivity for human immunodeficiency virus (hiv) * pregnancy or lactation * wbc count \ 14,000/ul * seropositivity for hepatitis b or c virus * hepatic enzymes \>=3x the upper limits of normal (uln) * history of active tuberculosis (tb) or currently undergoing treatment for tb * presence of malignancy within the past 5 years, including lymphoproliferative disorders * previous treatment with efalizumab (anti-cd11a) * diagnosis of hepatic cirrhosis, regardless of cause or severity * serum creatinine \>=2x the uln * hospital admission for cardiac disease, stroke, or pulmonary disease within the last year * history of substance abuse within the last 5 years * any medical condition that, in the judgment of the investigator, would jeopardize the subject's safety following exposure to study drug

Keywords: moderate plaque psoriasis severe plaque psoriasis topical
immunity against covid-19 vaccine in healthcare workers in argentine

Conditions: Coronavirus 2019; Healthcare Workers; Vaccine

Summary: vaccination against coronavirus disease 19 (covid-19) is an essential primary prevention tool to limit the health and economic effects of the pandemic. objectives: to determine the variation in the levels of immunoglobulin g (igg) antibodies in health workers who received a covid-19 vaccine.

vaccination against coronavirus disease 19 (covid-19) is an essential primary prevention tool to limit the health and economic effects of the pandemic. the ministry of health of the nation, designed the "strategic plan for vaccination", which the first line being the health workers " the national administration of medicines, food and medical technology authorized two emergency vaccines for administration, sputnik v and sinopharm vaccine. it is important to evaluate immunogenicity and its correlation with the long-term efficacy and safety profile of this vaccines. objectives: to determine the variation in the levels of immunoglobulin g (igg) antibodies in health workers who received a covid-19 vaccine between the time before the first dose, and after 1 month, 6 months and 12 months after the completion of the immunization, depending on whether they have received the sputnik v vaccine or the sinopharm vaccine, and correlate the immunoglobulin g levels with the presence of adverse events and infection with covid-19 methodology: design: observational and analytical study of a prospective cohort of healthcare workers immunized with some covid-19 vaccine. the presence of igg will be determined qualitatively and quantitatively. the immunoglobulin g titer in each period will be compared globally and according to the type of vaccine administered.

Eligibility criteria:
inclusion criteria: * subjects receiving any covid-19 vaccine. exclusion criteria: * subjects who do not agree to participate

Keywords: covid-19 vaccines health personnel
efficacy and safety of omega-3 lipid therapy in pediatric patients with parenteral nutrition-associated liver disease

Conditions: Short Bowel Syndrome; Cholestasis

Summary: this pilot study seeks to demonstrate the efficacy of an intravenous lipid preparation high in omega-3 fatty acids (omegaven) in the treatment of cholestasis in parenteral nutrition dependent patients with short gut syndrome.


Eligibility criteria:
inclusion criteria: * patient will be dependent upon parenteral nutrition (pn) * patient will have short gut syndrome (loss of \>50% of small bowel) * patient's guardian/caregiver provides informed consent for patient to receive therapy * pediatric patient ≤ 1 year of age * expected pn duration is greater than 30 days * direct bilirubin \>2.0 mg/dl measured on two occasions no more than one week apart exclusion criteria: * liver dysfunction secondary to cause other than pn verified by standard of care diagnostic procedures and lab work to rule out alternative causes of neonatal cholestasis. * any patient in whom omegaven therapy would be contraindicated, such as an allergy to any seafood product, egg protein, and/or previously established allergy to omegaven * impaired lipid metabolism * severe hemorrhagic disorder * unstable diabetes mellitus * collapse and shock, stroke/embolism, recent cardiac infarction, or undefined coma status

Keywords: short bowel syndrome cholestasis omegaven parenteral nutrition-associated liver disease
endo gia stapler with duet tissue reinforcement system (trs) used in pulmonary resections

Conditions: Lung Disease

Summary: the objective of this study is to confirm superiority between a test treatment group using endo gia stapler with duet tissue reinforcement system (trs) and a current international standard of care group using a conventional stapler in patients undergoing pulmonary lobectomy surgery, using a randomized comparative study of the frequency of intraoperative air leak.

air leak is a complication of pulmonary surgical procedures that include pulmonary lobectomy, segmentectomy, and bullectomy, reported to occur in 33% to 75% of cases. prolonged air leak continuing for more than 7 days is reported to have a prevalence of greater than 15%. the presence of a history of smoking, preoperative steroid use, emphysema, low pulmonary function, pleural adhesion, and apical lung wedge resection are shown to be risk factors for prolonged air leak which lengthens the duration of drain placement, increases the days of hospitalization, and reduces patient adl and qol. prolonged air leak may also result in serious complications, such as empyema. tissue reinforcement materials widely used as a pleural reinforcement to prevent air leaks during lung surgery, and are reported as a safe and effective material for body tissue reinforcement. covidien japan inc. has developed a surgical stapler (endo gia duet trs) with an attached reinforcement material. this study will investigate the reinforcement effect on the staple line of using the newly developed surgical stapler with an attached reinforcement material.

Eligibility criteria:
inclusion criteria: * the patient is between 20-79 years of age. * the patient is eligible to be given pulmonary lobectomy. * the patient is scheduled to undergo pulmonary lobectomy. * performance status 0\~1 (eastern cooperative oncology group classification). * the patient has no history of lung surgery. * the patient is healthy organ function. * the patient is scheduled for surgery with staplers . * the patient must be willing and able to participate in the study procedures and able to understand and sign the informed consent. exclusion criteria: * the patient has suffered thoracic trauma or has previously undergone pneumonectomy surgery. * the patient has an active bacterial infection or fungal infection. * the patient is undergoing continuing systemic administration (intravenous or oral) of steroids. * the patient condition is complicated by uncontrolled diabetes mellitus. * the patient participation is judged difficult due to study complications related to a psychiatric disorder or psychological symptoms. * the patient undergoes surgical procedure other than lobectomy during surgery. * reinforcement material other than the study materials are applied during surgery. * the patient judged unsuitable for study participation by the investigator for any other reason.

Keywords: lung disease lobectomy pulmonary resection
accuracy comparison of two cgms in hospitalized patients

Conditions: Type 1 Diabetes; Type 2 Diabetes

Summary: the purpose of the study is to determine the accuracy of two different continuous blood sugar monitoring systems in hospitalized patients by comparing them standard laboratory blood sugar testing in the hospital.


Eligibility criteria:
inclusion criteria: 1. all genders, admitted to uc san diego hillcrest medical center with an anticipated remaining length of stay of ≥24 hours 2. age ≥18 years at the time of consent 3. requiring standard of care intravenous insulin infusion therapy at the time of consent with an anticipated duration of intravenous insulin infusion ≥12 hours 4. willingness to provide informed consent and follow all study procedures exclusion criteria: 1. current bleeding disorder, treatment with anticoagulants, or platelet count below 50,000/ml at enrollment 2. lack of appropriate sites for sensor placement (sites must be free of scars, skin irritation, surgical wounds, dressings, etc.) 3. planned magnetic resonance imaging (mri) study within 24 hours of enrollment 4. any other condition that, based on investigator's judgment, would jeopardize patient safety during trial participation or would affect the study outcome
evaluation of amphotericin b in optisol-gs for prevention of post-keratoplasty fungal infections.

Conditions: Fuchs' Endothelial Dystrophy

Summary: with the increasing popularity of endothelial keratoplasty, a coincident increase in the rate of fungal infections post-keratoplasty has been seen in the united states. in this study, the eye bank will harvest pairs of donor corneas and randomize one cornea from each pair to be stored in optisol-gs per eye bank association of america guidelines. the eye bank will add amphotericin b 0.255 μg/ml (antifungal) to the storage solution for the mate cornea. the study donor corneas will be assigned to participants who are scheduled to undergo descemet membrane endothelial keratoplasty. the surgeons, participants, and evaluators will remain masked regarding the donor cornea storage solution assignment. the participants will be followed for 6 months.


Eligibility criteria:
inclusion criteria: * male or female at least 18 years of age and any race or ethnicity * scheduled to have descemet membrane endothelial keratoplasty exclusion criteria: * history of glaucoma surgery in operative eye * known allergy or intolerance to amphotericin b * presence of anterior chamber intraocular lens * corneal stromal or epithelial dysfunction * presence of glaucoma defined as optic nerve damage as confirmed on humphrey visual field testing or retinal nerve fiber layer analysis * presence of peripheral anterior synechiae
effect of hand-washing training in covid-19

Conditions: Chronic Disease; Covid-19 Pandemic

Summary: this study was conducted in order to inform, the women with chronic disease in rural areas, about hand-washing and nutrition, and to evaluate the efficiency of the training program. a randomized-controlled trial was performed based on consort checklist. 90 women in total were included in the study, 45 for each group. the women in the intervention group were given, by the researcher, the training on the importance of hand-washing and appropriate food choices. the training given to the women in rural areas created significant benefit for them to have the appropriate food choices and hand-washing behaviours.


Eligibility criteria:
inclusion criteria: * be women, agreeing to participate. exclusion criteria: * be man, unable to communicate.

Keywords: covid-19 hand hygiene chronic disease
mechanism-based choice of therapy for pain: can successful prevention of migraine be coupled to a psychophysical pain modulation profile?

Conditions: Migraine

Summary: mechanism-based choice of therapy for pain: can successful prevention of migraine be coupled to a psychophysical pain modulation profile?


Eligibility criteria:
inclusion criteria: * female and male migraine patients with a number of month attacks ≥ 4, * age 18-75, * without any other chronic pain. exclusion criteria: * any migraine preventive treatment for last 6 month \& psychiatric, * language or cognitive dysfunction precluding use of psychophysics.

Keywords: migraine patients
cognitive remediation in early substance abuse treatment

Conditions: Substance-Related Disorders

Summary: this study is for the purpose of determining whether cognitive remediation may improve cognition and treatment response in patients entering substance abuse day treatment

background: patients entering substance abuse treatment display cognitive deficits that may reduce their ability to benefit from their treatment. while there is considerable variety in the severity and types of cognitive impairment found in newly recovering patients, problems with attention, memory and executive function are very common. since treatment requires sustained attention, remembering what is learned, integrating that knowledge and applying it to recovery, impairment in underlying cognitive processes makes successful treatment less likely. although cognitive functioning improves with sustained sobriety, it is during the early phase of recovery that most patients receive the most intensive treatment. recent research has suggested that cognitive remediation exercises during this early phase may speed up the return of cognitive functioning and in so doing may have a direct effect on whether patients find the treatment useful and complete their treatment. by keeping patients in treatment longer, cognitive remediation may have an indirect effect on substance abuse outcomes. objectives: to pilot test the introduction of cognitive remediation at the substance abuse day treatment program (sadp) at the errara community care center. aims are 1) to assess the receptivity of patients to the intervention by determining rates of agreement to participate, 2) to determine the number of cognitive remediation sessions that patients are willing to engage in, 3) to assess a variety of cognitive remediation tasks for their acceptability, 4) to evaluate neuropsychological improvements using pre-post assessment, 5) to evaluate its effects on substance abuse treatment participation, and 6) to evaluate its effects on substance abuse outcomes at 6 months follow-up. design: randomized clinical trial of cognitive remediation with an active control condition with observations at baseline, end of treatment and 6-months from intake

Eligibility criteria:
inclusion criteria: * veterans participating in a substance abuse day treatment program at the errara community center exclusion criteria:

Keywords: psychology: cognitive aspects substance-related disorders treatment efficacy
availability of lipids in almonds in healthy individuals

Conditions: Obesity; Overweight

Summary: evidence indicates that almond consumption is associated with multiple health benefits. however, nuts are commonly excluded from diets on the basis that their high energy content may induce weight gain. evidence from numerous studies show that this is not the case, yet the mechanism responsible for the less than predicted effect on weight is unknown. this study aimed to examine the effects of increased mastication on lipid bioavailability and satiety related peptide released in humans. its purpose is to provide valuable mechanistic data to support the results from previous completed clinical studies.

this cross-over study consisted of three study periods of four consecutive days separated by at least one week. during each day of the three study periods, participants were required to consume 55g of almonds split up into 5 g portions. they were required to chew the almonds 10, 25, or 40 times before swallowing, depending on the treatment. during each treatment period, all participants followed the same procedures over the four days. on day one after an overnight fast, participants reported to the laboratory and were presented with 11, 5 gram portions of almonds to chew 10, 25, or 40 times, depending on treatment arm. the participant remained in the laboratory for 4 hours post-almond consumption for measurements of blood and appetite. for the remainder of the 4 days, participants consumed all meals in the laboratory and collected all stools passed. on a separate occasion, recovered particle sizes of masticated almonds were measured by a mechanical sieving process. individuals chewed almond samples either 10, 25 or 40 times and expectorated them into sieves.

Eligibility criteria:
inclusion criteria: * 18-50 years of age * bmi 20-25 kg/m2 * full set of healthy teeth * weight stable (\<3 kg change in past 3 mo) exclusion criteria: * smoker * eating disorders or high level of restraint * endocrine disorders * pregnant or lactating * allergic to nuts * taking medication likely to confound study outcomes (meds affecting appetite)

Keywords: nuts lipids mastication bioaccessibility satiety hormones human