Kornimate/medical-research-clean huggingface dataset:
effects of continuous nerve block vs single injection block with pca vs pca on pain and function after knee replacement

Conditions: Pain

Summary: the purpose of this study is to compare the effectiveness of three analgesia techniques on pain relief and functional recovery after knee replacement: continuous femoral nerve block vs single-injection femoral nerve block with intravenous patient controlled analgesia vs intravenous patient controlled analgesia.

primary outcome measures: * incidence of patients with significant pain on movement on day 1 post surgery * range of knee flexion secondary outcome measures: * pain intensity (rest/movement) * functional recovery * knee injury and osteoarthritis score * side effects/ adverse outcomes * sf12 quality of life questionnaire * length of stay

Eligibility criteria:
inclusion criteria: * 40 years and above * osteoarthritis * primary unilateral total knee replacement * no other lower extremity joint disease * asa i-iii * body mass index \< 35 * no severe cardiac or pulmonary diseases * no chronic narcotic therapy or illicit drug use * mentally competent to understand study procedures and use of pain scales * able to provide informed consent exclusion criteria: * any cause for knee replacement other than osteoarthritis * total knee revision * any contraindication for femoral block * abnormal coagulation studies * thrombocytopenia less than 100,000/cc * known hepatic or renal insufficiency * neurological disease involving lower extremities * major surgery during the last 2 weeks pre-operatively * history of allergy to study medications * history of post-operative bleeding over 2000 cc/24 hours * history of opioid or alcohol abuse * currently taking or has taken opioid \> 30 consecutive days of daily use at a daily dose \> 15mg morphine, within the past 2 weeks prior to surgery * previously has not responded to opioid analgesics for treatment of pain * pregnancy or breastfeeding

Keywords: knee replacement analgesia analgesics nerve blocks recovery of functions post operative analgesia
nmes in hf patients to improve functional recovery following hospitalization

Conditions: Heart Failure With Preserved Ejection Fraction

Summary: the goal of this research study is to understand whether an at-home exercise program started after hospitalization for hfpef, and continuing for 4 weeks following discharge from the hospital, can preserve or improve physical function.

heart failure is the leading cause of hospitalization among adults in the us with patients with preserved ejection fraction (hfpef) comprising half of those admissions. many patients exhibit chronic fatigue, exercise intolerance and an inability to perform activities of daily living, which is exacerbated by hospitalization. the goal of this research study is to understand whether an at-home exercise program started soon after hospitalization and continuing for 4 weeks following discharge can improve functional recovery in hfpef patients. volunteers will be randomly assigned to receive neuromuscular electrical stimulation (nmes) of their quadriceps muscles or not to receive nmes (control group). volunteers will be evaluated during hospitalization and 4 weeks following discharge. assessments will include measurements of physical function by 6 minute walk test and the short physical performance battery, as well as assessment of subjective physical functional capacity and quality of life using the medical outcomes short form 36 and kansas city cardiomyopathy questionnaire.

Eligibility criteria:
inclusion criteria: * 50-90 years of age * clinical diagnosis of hf being actively managed during hospitalization * live within 30 miles of the medical center * able to perform informed consent exclusion criteria: * rheumatoid arthritis or other inflammatory/autoimmune disease * cancer, excluding non-melanoma skin cancer or low-grade prostate cancer * severe dementia/alzheimer's disease * exercise limiting peripheral vascular disease * neuromuscular disease or neuromuscular dysfunction associated with cerebrovascular event * body mass index ≥40 kg/m2 * lower extremity blood clot or implantable cardioverter-defibrillator or pacemaker

Keywords: hf, rehabilitation
crestor rapid (the efficacy of rosuvastatin for korean dyslipidemia patients with diabetes)

Conditions: Dyslipidemia; Diabetes

Summary: to evaluate the efficacy of rosuvastatin in korean dyslipidemia patients with diabetes


Eligibility criteria:
inclusion criteria: * hyperlipidemia patients who are prescribed with rosuvastatin 10mg, based on clinical grounds and fulfil the following criteria 1. over 18 years of age 2. diagnosed with dm based on fasting or post-load glucose data and/or clinical assessment by the clinician exclusion criteria: 1. patients already taking other hyperlipidemic agents 2. patients who do not fulfil the indication criteria for statin therapy 3. patients who do not have baseline and/or follow-up lipid data to verify the efficacy data

Keywords: dyslipidemia rosuvastatin diabetes cholesterol naturalistic observational
wmt for autism spectrum disorder (asd)

Conditions: Autism Spectrum Disorder

Summary: autism spectrum disorder (asd) is a group of serious neurodevelopmental disorders. intestinal microbial disturbance is common in children with asd. a great deal of evidence shows that intestinal microbes can influence the brain to play its role through "gut-brain-microbiota axis". we intend to explore the role of washed microbiota transplantation in improving symptoms of children in autism spectrum disorder; to study the potential etiological mechanism of autism spectrum disorder.

very few literatures reported the clinical use of microbiota or bacteria for autism spectrum disorder. the most effective strategy for reconstruction of gut microbiota should be fecal microbiota transplantation (wmt). washed microbiota transplantation (wmt) can significantly reduce fmt-related aes by removing parasite eggs, fecal particles, and fungi through a series of automated washing procedures. this study aims to evaluate the efficacy and safety of fmt for asd. patients received repeated wmt with fecal from healthy donors. microbiota analysis will also be performed on both the donor and recipient stool sample prior to transplantation, and on the recipient sample at 3 month post transplantation. this study sought to evaluate the efficacy of washed microbiota transplantation (wmt) in children with asd and explore the role of washed bacteria transplantation in improving asd symptoms.

Eligibility criteria:
inclusion criteria: * children who meet diagnostic and statistical manual of mental disorders, fifth edition (dsm-5) diagnostic criteria for at least 3 months. * age 3-14years. * received wmt exclusion criteria: * their guardian could not understand the questionnaires or provide informed consent. * diagnosed with a single-gene disorder, major brain malformations, gastrointestinal diseases (ulcerative colitis, crohn's disease, or eosinophilic esophagitis) * had severe comorbidities including cardiopulmonary failure, severe liver, and kidney diseases, severe infection, tumors, etc. * accompanied with other life-threatening disorders required emergency treatment. * used antibiotics or probiotics three months before wmt.

Keywords: fecal microbiota transplantation autism spectrum disorder gut microbiota gut-brain axis
feasibility and safety of functional performance testing in patients undergoing hematopoietic cell transplantation

Conditions: Acute Myeloid Leukemia; Myelodysplastic Syndrome; Hematological Malignancy; Leukemia; Lymphoma; Myeloma

Summary: the purpose of this study is to see if exercise fitness testing is feasible and safe in persons over 21 years of age who have been diagnosed with a hematological malignancy and are scheduled to undergo a hematopoietic stem cell transplant (hct). assessments in this study will look at the capacity of the body before transplantation to see if these measures can help predict how patients do after transplant.


Eligibility criteria:
inclusion criteria: * patients with msk histologically confirmed hematologic malignancy * scheduled for autologous or allogenic hct at mskcc * ≥21 years old * ecog performance status of 0 or 1 * completion of baseline cpet * willing to comply with protocol related procedures exclusion criteria: * any of the following absolute contraindications to cardiopulmonary exercise testing * acute myocardial infarction (within 3-5 days of any planned study procedures) * unstable angina * uncontrolled arrhythmia causing symptoms or hemodynamic compromise * recurrent syncope * active endocarditis * acute myocarditis or pericarditis * symptomatic severe aortic stenosis * uncontrolled heart failure * acute pulmonary embolus or pulmonary infarction within 3 months of any planned study procedures * thrombosis of lower extremities * suspected dissecting aneurysm * uncontrolled asthma * pulmonary edema * respiratory failure * acute non-cardiopulmonary disorders that may affect exercise performance or be aggravated by exercise (i.e., infection, renal failure, thyrotoxicosis) * presence of any other concurrent, actively treated malignancy; * history of any other malignancy treated within the past 3 years (other than non-melanoma skin cancer); * room air desaturation at rest ≤85% * mental impairment leading to inability to cooperate

Keywords: functional performance testing exercise fitness testing 15-274
prognostic impact of the location of mitral valve prolapse on the long-term results of mitral plasty

Conditions: Mitral Valve Prolapse; Mitral Plasty

Summary: mitral insufficiency (mi) accounts for 24% of adult valvulopathies and affects 7% of subjects older than 75 years. they are the second leading cause of valvulopathy in europe. the most common etiology is the associated valvular prolapse. mitral surgery remains the reference treatment for symptomatic mi. the success of this procedure depends on the mitral valve geometry and the location of the prolapse. the site of the prolapse, whether monovalvular, localized to the posterior or anterior leaflet, or bivalvular, influences the possibilities and probably the long-term results of the plasty.


Eligibility criteria:
inclusion criteria: * patients operated between 1988 and 2011 * presence of a valvular prolapse diagnosed by echocardiography * possibility of a complete clinical evaluation at the time of the initial echocardiography exclusion criteria: * ischemic mi (including papillary muscle rupture) * presence of significant aortic valvulopathy, mitral valvular stenosis or congenital disease * history of cardiac surgery
changes in phenotype and genotype of breast cancers during the metastatic process and optimization of therapeutic targeting (esope)

Conditions: Metastatic Breast Cancer

Summary: the primary objective is to compare the phenotype and genotype of the primary tumor with those of its metastases in order to optimize the treatment of metastatic disease, in patients presenting with first metastatic progression of breast cancer.


Eligibility criteria:
inclusion criteria: to be eligible to participate in the study, patients must fulfill all of the following criteria: female patients. age ≥ 18 years. ecog performance status ≤ 2. metastatic breast carcinoma, either at diagnosis or at first metastatic relapse. available ffpe +/- frozen primary tumor samples. evaluable metastatic disease. metastatic disease outside any previous radiotherapy field (e.g. sub-clavicular or internal mammary lymph nodes). metastatic disease accessible to either percutaneous or surgical sampling. signed written informed consent (approved by an independent ethics committee and obtained prior to any study-specific screening procedure). social and psychological welfare in concordance with compliance to the study. exclusion criteria: to be eligible to participate in the study, patients must fulfill none of the following criteria: bilateral or multifocal breast cancer. isolated local or contralateral relapse. solitary bone and/or brain metastatic disease unless : metastatic sites eligible for a therapeutic surgery. metastatic sites sampled for diagnosis purpose. past or current history of malignant neoplasms, except for curatively treated basal and squamous cell carcinoma of the skin. carcinoma in situ of the cervix. any coagulopathy contraindicating tumor biopsy. presence of a contraindication to general anesthesia, if required.

Keywords: metastatic breast cancer tumor biopsy phenotype and genotype characterization
rigid telescopes, c-mac, flexible bronchoscopy for intubation in patients with anticipated difficult airways

Conditions: Videolaryngoscopy

Summary: the primary outcome of the study is the first-attempt orotracheal intubation success rate and the secondary outcomes include intubation time, mucosal injury, and complications during intubation.

difficult airway management in phonomicrosurgery requiring endotracheal tube (ett) placement is highly important for both the anesthetist and the surgeon. the use of rigid telescopes in the intubation of children with difficult intubation, such as those with pierre robin sequence (prs), has been previously described in the literature. in addition, the use of airtraq™ and rigid endoscopes in patients undergoing phonomicrosurgery, particularly in patients with difficult laryngoscopy, has also been reported in the literature. however, the uses of these techniques have mostly been described in the administration of surgery or in defining airway disease. in this study, we aimed to evaluate the use of rigid telescopes during intubation, particularly in patients with a difficult airway, and to compare them with videolaryngoscope macintosh (v-mac) and flexible fiberoptic bronchoscope.

Eligibility criteria:
inclusion criteria: patients with a modified cormack-lehane (c-l) grade of 3 and 4, wilson score of ≥ 6, thyromental distance (tmd) distance of ≤ 6 cm, sternomental distance (smd) ≤ 13. exclusion criteria: patients that had severe mouth opening (\<2.5 cm), required nasotracheal intubation, upper airway and pharyngeal diseases, presence of cervical spine anomalies, emergency procedures, failed mask ventilation, asa iii and iv score, patients who were allergic to any of the drugs to be used during premedication and anesthesia.

Keywords: airway management, difficult airway, tracheal intubation
the effects of preoperatively chewing gum on sore throat after general anaesthesia with a laryngeal mask

Conditions: Postoperative Sore Throat

Summary: postoperative sore throat (post) is an important problem after general anaesthesia. we assessed whether chewing gum preoperatively can reduce the incidence of post after general anaesthesia administered via a streamlined liner of the pharyngeal airway (slipa).


Eligibility criteria:
inclusion criteria: american society of anaesthesiologists (asa) class i or ii 20-65 years body mass index (bmi) scores \<30 undergoing elective hysteroscopic surgery - exclusion criteria: chronic laryngitis chronic bronchitis asthma gastroesophageal reflux allergies to study drugs recent use of non-steroidal anti-inflammatory drugs (nsaids) a history of upper respiratory tract infection in the past one week mallampati grade\>2 a history of steroid therapy. -
continuous glucose monitoring and inflammation in nondiabetic and diabetic patients undergone hemodialysis

Conditions: Diabetes; End Stage Renal Disease

Summary: evaluation of different glycemic variations between the dialysis period and non-dialysis period in two groups: nondiabetic and diabetic patients undergone two different hemodialysis methods. thirty-six patients, males and females, aged 50-80 years, with end stage renal disease (esrd) will undergo hemodialysis and continuous glucose monitoring (cgm). the investigators will evaluate also inflammation markers before and after the different hemodialysis methods.


Eligibility criteria:
inclusion criteria: * patients with or without diabetes mellitus * esrd * undergone hemodialysis * males and females aged 50-80 exclusion criteria: * tumors * chronic inflammation diseases * ami * acute pulmonary diseases

Keywords: diabetes mellitus esrd cgm inflammation markers hemodialysis diabetic patients nondiabetic patients all with esrd all undergone hemodialysis
the impact of obesity on children and adolescents.

Conditions: Obesity; Cardiovascular Risk Factors

Summary: the aim of the study is to investigate the association of obesity with arterial blood pressure, atherosclerosis, target organ damage (heart, arteries, kidney) and insulin resistance in children and young adolescents.


Eligibility criteria:
inclusion criteria: * overweight (85th\ =95th percentile) children and adolescents * no medication treatment (apart from bronchodilators, t4 in euthyroid children) * no severe mental problem * parents' and patients' signed consent exclusion criteria: * severe chronic or acute cardiac disease or other severe chronic or acute disease * any acute inflammation * familial dyslipidemia * clinical hypothyroidism or other endocrinopathy * poor compliance.
iona longitudinal cohort study

Conditions: Alzheimer Disease; Dementia

Summary: understanding more about how diseases that cause dementia develop is critical as the number of people living with, or affected by, dementia in scotland continues to grow. the iona longitudinal cohort study (lcs) has been set up to gather information about people's cognitive health (their memory and thinking abilities), their lifestyle and health risk factors for future dementia (such as hearing loss and obesity), genetics and disease biomarkers, over a number of years. the iona lcs has three main objectives: firstly to develop this cohort that is well characterised (also known as being "well-phenotyped") that represent the scottish population (taking into consideration age, sex, ethnicity and education). the second objective is to use this data to build disease models to better understand trajectories of diseases, and identify any sub-populations who have different (i.e. better, worse) disease trajectories. finally the third objective for iona lcs is to offer people an optional consent to hear about future studies they may be interested in taking part in.

ithe iona longitudinal cohort study (lcs) will provide a well-phenotyped (combining data on risk factors for dementia, cognitive assessment results, disease biomarkers and genetics) population representative of the scottish population aged 50 and above across the spectrum of risk for, and the earliest disease stages of, ad dementia and other neurodegenerative conditions. recent therapeutic successes in the treatment of mild cognitive impairment (mci) due to alzheimer's disease (ad) and mild ad, as well as progressions in diagnostic tools such as blood-based biomarkers, has energised the field to develop more specific diagnostics and therapies following the best principles of precision medicine. large, 'real world' cohorts are needed to understand whether these, and other future breakthroughs, are valid in real world populations away from highly selective clinical trials. precision medicine requires identification of disease sub-populations who share similar diagnostic profiles that reflect similar disease mechanisms and hence are likely to respond consistently to specific therapeutic interventions. this will require detailed clinical, genetic and biological phenotyping. iona lcs will recruit uniquely in scotland and will ensure that a large, diverse, real-world population will be available to drive developments globally of more accurate diagnostics and accelerate the development of new disease modifying therapies.

Eligibility criteria:
* age at least 50 years. * living in scotland. * able to read and write and with minimum 7 years of formal education. * have a study partner who is aged 18 years or older. * have capacity to provide informed consent at baseline. * able to speak english to a level where the cognitive assessments can be completed.

Keywords: cohort study alzheimer disease dementia
mobile health intervention to improve exercise in pediatric ph

Conditions: Pulmonary Arterial Hypertension

Summary: children and adults with pulmonary arterial hypertension (pah) have severely reduced daily activity compared to healthy populations. in adults, investigators recently demonstrated that lower baseline daily step counts associated with increased risk of hospitalization and worsening who functional class; similarly, reduced step counts associate with hospitalization in children with pah. this application builds on our recently completed nih-funded pilot mobile health (mhealth) trial in adult patients with pah which demonstrated the ability to remotely increase step counts. the investigators now aim to: (1) adapt our mhealth intervention to the developmental needs and interests of adolescents; and, (2) determine if our intervention increases step counts in adolescents, providing the foundation for a larger trial to assess the impact on quality of life and clinical outcomes.


Eligibility criteria:
inclusion criteria: * adolescents between ages 13-19 years. * diagnosed with idiopathic, heritable, or associated (connective tissue disease, drugs, or toxins) pulmonary arterial hypertension (pah), or pah due to simple congenital heart disease (i.e. atrial septal defect). * who functional class i-iii * stable pah-specific medication regimen for three months prior to enrollment. subjects with only a single diuretic adjustment in the prior three months will be included. adjustments in iv prostacyclin for side effect management are allowed. * forced vital capacity \>65% predicted with no or minimal interstitial lung disease based on reviews of imaging studies by pi and medical monitor. exclusion criteria: * prohibited from normal activity due to wheelchair bound status, bed bound status, reliance on a cane/walker, activity-limiting angina, activity-limiting osteoarthritis, or other condition that limits activity. * pregnancy * diagnosis of pah etiology other than idiopathic, heritable, or associated. * functional class iv heart failure * requirement of \> 2 diuretic adjustment in the prior three months. * preferred form of activity is not measured by an activity tracker (swimming, yoga, ice skating, stair master, or activities on wheels such as bicycling or rollerblading). * involved in any other investigational intervention.
oxytocin administration in the third stage of labour - a study of appropriate route and dose

Conditions: Third Stage of Labour

Summary: mothers are given the medication oxytocin after birth to help the uterus (womb) contract and therefore reduce blood loss. in canada, oxytocin is given either into the muscle of the thigh or into a vein. however, it is not known which route is better.this study will test which dose and route of oxytocin is best in reducing blood loss following vaginal delivery.


Eligibility criteria:
inclusion criteria: * women 19 years and older * singleton pregnancy * 32 weeks gestation * spontaneous vaginal delivery exclusion criteria: * previous postpartum hemorrhage * placenta previa * grand multiparity (\>4) * anticoagulation therapy * delivery prior to 32 weeks gestation * operative vaginal delivery * antepartum hemorrhage \> 20 weeks * hemoglobin \<10g/dl * multiple gestation * intrauterine death

Keywords: oxytocin third stage dose route blood loss