Kornimate/medical-research-clean huggingface dataset:
impact of two guided transfusion strategies on blood product requirements in liver transplantation.

Conditions: Fibrin Blood Clot

Summary: it is a national multicentre clinical study, where 3 hospitals are involved: bellvitge university hospital, clinic hospital of barcelona and cruces hospital of bilbao). it is a randomized study based on the hemoglobin value of the patient with a 1:1 ratio, parallel groups, controlled and single blind, in patients undergoing an orthotopic liver transplant, confirming previously that the participants fulfill all the inclusion criteria and none of exclusion.

a total of 176 patients will be included (88 per group) and each center can not include more than 40% of the sample to avoid bias. blood samples will be analyzed at different times of the surgical intervention by an electronic device called thromboelastogram. it evaluates the blood clot characteristics and, depending on the results, assesses the need to correct values by the administration of fibrinogen or platelets. one of the coagulation parameter evaluated and corrected by thromboelastogram is called a10fibtem. in a previous study, the investigators have seen that maintaining some specific ranges in the a10fibtem, results in a decrease of the use of blood products. that's why the investigators have created 2 groups: * the control group will be corrected up to a value of a10fibtem = 8mm. * the intervention group will be corrected up to a value of a10fibtem = 11mm. subsequently, results between groups will be compared. the investigators have to consider that the drug used in this study (riastap) is an authorized and commercial drug. the main objective is to demonstrate that the administration of fibrinogen in the intervention group compared to the control group changes the administration of red blood cells pack during the liver transplant and in the first 24 hours after. secondary objectives consist in demonstrate that in the intervention group, there is also a change in the administration of other blood products, a change in acute renal damage, a change in hours of mechanical ventilation, no changes in thrombotic events in the hepatic graft or in the patient in the first 90 days of the liver transplant and no changes in re operations, re-transplantation, or mortality during the first 90 days of the liver transplant, compared to the control group.

Eligibility criteria:
inclusion criteria: * age \> 18 years. * candidate to an orthotopic liver trasnplantation. * informed consent. * preoperative hemoglobine \</= 130 g/l exclusion criteria: * preoperative hemoglobin\> 130 g / l * familial amyloid polyneuropathy * polycystosis hepatic * living donor liver transplant * uncontrolled donor after cardiac death * acute / subacute liver failure * re-transplant (in the same hospital admission) * use of anticoagulation drugs before transplantation. * age \<18 years. * pregnancy and lactation.

Keywords: fibrinogen red blood cell pack transfusion orthotopic liver transplantation
regadenoson combined with symptom-limited exercise in patients undergoing myocardial perfusion imaging

Conditions: Coronary Artery Disease; Myocardial Ischemia

Summary: not infrequently, a physician is faced with uncertainty regarding the ability of a patient to perform adequate exercise in the noninvasive evaluation of known or suspected coronary artery disease (cad) by the use of radionuclide stress myocardial perfusion imaging. in selected patients, protocols that combine exercise (either low-level or symptom-limited) with vasodilator stress agents have been found to be safe and effective in both identification of the presence and severity of cad as well as risk stratification for adverse cardiac outcome. however, currently utilized combined stress protocols have drawbacks. further refinement of combined stress protocols would potentially lead to more appropriate stress protocol selection for patients while enhancing laboratory efficiency. the purpose of this prospective, randomized study will be to evaluate the relative merits of combining regadenoson with symptom-limited exercise in patients clinically-referred for vasodilator-exercise stress myocardial perfusion imaging for the assessment of known or suspected cad. it is hypothesized that combining regadenoson with symptom-limited exercise is a safe and feasible stress testing modality which is non-inferior to that which combines symptom-limited exercise with dipyridamole.


Eligibility criteria:
inclusion criteria: * males and non-pregnant, non-nursing females clinically referred for vasodilator stress myocardial perfusion imaging with the addition of exercise * age \>=30 years exclusion criteria: * extremely limited functional capacity * age \<30 years * unable or unwilling to provide informed consent * pregnant or nursing females * current use of methylxanthines within 12 hours of testing * current use of dipyridamole or aminophylline within 48 hours of testing * uncontrolled hypertension (\>200 mmhg systolic/\>120 mmhg diastolic) * known hypertrophic cardiomyopathy with obstruction or severe aortic stenosis * decompensated congestive heart failure * history of sick sinus syndrome or \> first degree atrioventricular block in the absence of a functioning pacemaker * asthma or other bronchospastic reactive airway disease * history of percutaneous coronary intervention or coronary artery bypass grafting, or documented history of acute myocardial infarction or unstable angina within one week of testing * patients at risk for hypotensive reaction to regadenoson
flurbiprofen axetil for uterine contraction pain

Conditions: Postoperative Pain

Summary: uterine contraction pain is a common problem after abortion. optimal analgesic for such suffering is still needed to be guaranteed. flurbiprofen axetil is a target-distributable non-steroidal anti-inflammatory drug (nsaid) functioning via block the synthesis of prostaglandin e (pge). the investigators hypothesized that flurbiprofen axetil could suppress the uterine contraction pain after abortion effectively.


Eligibility criteria:
inclusion criteria: * asa status i-ii * performing abortion operation (medical- or drug-induced * requiring painless abortion exclusion criteria: * \ = 45yrs * history of central active drugs administration * drug abuse * hypertension * diabetes * any other chronic diseases * allergy to the study drugs * habit of over-volume alcohol drinking * records of history of centrally active drug use and psychiatry * any organic disorders

Keywords: nsaids postoperative pain analgesia abortion
combination of motor imagery exercises and brain stimulation tms type pas in patients after hemiplegic stroke

Conditions: Stroke

Summary: strokes represent, in industrialized countries the leading cause of acquired motor disability in adults older than 40. stroke is responsible for france from 150 000 to 200 000 new cases of hemiplegia each year. these patients will see their deficit to improve during the first 6 months after stroke. this recovery is largely based on brain plasticity mechanisms and the rehabilitation has as main objective to optimize these mechanisms. however, only 20% of patients hospitalized in a rehabilitation sector recover a functional upper limb. this lack of functionality is not only due to overall strength gap but also to the predominance of this gap on the extension movements of the wrist and fingers. meanwhile, work on brain plasticity helped develop new techniques of non-invasive brain stimulation (non-invasive brain stimulation, nibs) as the model of coupled stimulations (paired associative stimulation, pas) for modulating way over effective brain plasticity. in previous studies, the investigators have shown over a 30 minutes session lasting facilitation (60mn) and specific motor evoked potential (mep) of the extensor carpi radialis (ecr). several studies showed an adjuvant effect when gsin were associated with learning of a motor task. for pas, some studies have shown a greater facilitation when the latter is associated with muscle contraction. the motor imagery (mi) is imagining a movement without realizing it, it is based on mechanisms similar to those of the real movement. this technique also showed its effects as an adjuvant therapy in hemiplegic patients, however, they remain lower than those obtained after a motor drive. its use in patients with no motor makes its uniqueness and strength.


Eligibility criteria:
inclusion criteria: * 18-85 years * patients who have experienced a stroke of more than one month * deficit out of the upper limb (fugl meyer member sup \<50/66) * presence of ecr muscle mep * able to carry the motor imagery according to a test by measuring chronometer * patient who signed informed consent * subject affiliated to the social security system exclusion criteria: * history of epilepsy or seizure * mep lack of ecr * presence of a cons-indication for use of magnetic stimulation or mri: * surgical clips, metal sutures, staples, stent * osteosynthesis devices on the head or neck * pacemaker * implanted hearing aid * ocular foreign body, shrapnel, bullets * metal worker * heart valve, endovascular equipment * ventricular bypass valve * pace-maker or neurostimulator * claustrophobia * incapable adult patient, safeguard justice, guardianship or trusteeship * pregnant women and / or breastfeeding (because lack of data in the literature regarding the absence of foetotoxic effect)

Keywords: hemiplegia
short-term glucocorticoid combined with mmf for igg4-rd

Conditions: IgG4-related Disease

Summary: comparison of short-term glucocorticoid monotherapy and short-term glucocorticoid combined with mmf in the treatment of igg4 related disease

this is a monocenter, 72-week prospective, randomized controlled study to compare short-term glucocorticoid monotherapy and short-term glucocorticoid combined with mmf in the treatment of igg4 related disease.

Eligibility criteria:
inclusion criteria: 1. 18-80 years old; 2. all patients must meet the comprehensive diagnostic criteria of igg4-rd revised in japan in 2020 or the classification criteria of igg4-rd formulated by acr/eular in 2019; 3. active igg4-rd (at least one organ has an igg4-rd reaction score \>=2 at the time of enrollment.)； 4. no previous medication or recurrence after withdrawal. exclusion criteria: 1. combined with other autoimmune diseases as the main diagnosis. 2. pregnant or lactating women 3. patients with malignant tumor 4. active bacterial, fungal, viral or mycobacterial infections. 5. severe complications of important organs, and the expected survival time is less than 6 months.

Keywords: igg4-related disease
an investigation of n-acetylcysteine and fenoldopam as renal protection agents for cardiac surgery

Conditions: Kidney Failure, Acute; Kidney Failure, Chronic; Cardiac Surgical Procedures

Summary: patients with abnormal kidney function are at increased risk for complications following heart surgery, including worsening kidney function possibly requiring dialysis, a prolonged stay in the critical care unit and hospital, and the increased risk of death. prior attempts at kidney protection for heart surgery patients have had mixed results. two medicines, fenoldopam and n-acetylcysteine, have been shown to protect kidney function in other circumstances that cause kidney stress. the purpose of this study is to determine whether these medications will help to maintain the function of diseased kidneys during heart surgery.

this is a randomized, double-blinded, placebo-controlled trial to evaluate fenoldopam and n-acetylcysteine (nac) individually, and together, as renal protective agents for patients with renal insufficiency undergoing heart surgery. subjects have chronic renal insufficiency with creatinine clearance (crcl) \</= 40cc/min but not on pre-operative dialysis, and receive: nac 600 mg by mouth (po) twice a day (bid) or placebo starting 24 hours pre-operative and continuing through the day of surgery; and/or fenoldopam 0.1 mcg/kg/min intravenous (iv) or saline placebo at anesthetic induction and continuing for 48 hours. outcome data include: nadir, post-operative day 3 and post-operative day 14 crcl, time to crcl nadir, length of intensive care unit (icu) stay, length of post-operative hospital stay, hospital costs, mortality, and the need for hemodialysis. intraoperative and post-operative pressor use is being monitored. the enrollment will include 80 patients (20 in each group).

Eligibility criteria:
inclusion criteria: * chronic creatinine clearance \</= 40cc/h * pre-operative cardiac surgery exclusion criteria: * pre-operative ongoing dialysis * nausea and vomiting * uncontrolled glaucoma * allergy to metabisulfite * enrollment in another clinical study within 30 days * pregnancy * acute renal failure

Keywords: kidney failure cardiac surgery fenoldopam n-acetylcysteine
prospective study of a size tailored approach to repair umbilical and epigastric primary ventral hernias

Conditions: Ventral Hernia; Umbilical Hernia; Epigastric Hernia

Summary: primary ventral hernias, such as umbilical and epigastric hernias, are best repaired with abdominal wall reinforcement by mesh implantation. mesh-devices using a dual-sided mesh technology have been developed for the specific indication of small ventral hernias; this technique is very attractive because the mesh can be introduced through a nearly invisible scar in the umbilicus. the dual layer of the mesh inhibits the formation of adhesions of the viscera to the mesh so, if wanted, it can be positioned in a intraperitoneal position. no literature is available on the adequate size of mesh needed to repair a hernia defect of an umbilical or epigastric hernia. very small hernias are now often enlarged for repair with a large mesh device. small hernias might benefit of repair with a small mesh device so no enlargement of the defect is necessary larger hernias might benefit from a larger mesh size to have more overlap of the mesh beyond the hernia defect. with this prospective cohort study the investigators want to explore the efficacy of c-qur v-patch of different sizes for the different sizes of hernia defects.


Eligibility criteria:
inclusion criteria: * all adult patients that are planned for surgical repair of a primary umbilical or epigastric hernia will be considered to enter the study. exclusion criteria: * patients refusing to participate at the follow up visits * pregnancy * age \< 18 years * life expectancy less than 12 months * recurrent umbilical or epigastric hernia * incisional or trocar site hernias * emergency operations * liver cirrhosis or ascites * cancer patients * concomitant surgery

Keywords: primary ventral hernia repair with mesh umbilical hernia repair epigastric hernia repair c-qur v-patch size tailored repair preperitoneal repair abdominal hernia dual sided mesh
study of the effects of adapted tango and multidimensional intervention in prevention of dementia in aging (strength)

Conditions: Mild Cognitive Impairment

Summary: the strength project is a randomized controlled trial to assess the effects of a 6 months multimodal intervention consisted of adapted tango dancing together with music therapy, engagement in social activities, cognitive intervention and psycho-education on functional, biological, cognitive outcomes and psycho-social aspects in 300 subjects with mild cognitive impairment.

cognitive decline represents a pathological condition for elderly with negative consequences on social functioning and independent living. to reduce the incidence of cognitive deficits in mild cognitive impairment (mci), treatments that prevent or delay dementia are needed. the main objective of strength project, is the assessment of the effects of a comprehensive intervention in 300 subjects with mci, finalized to improve functional, biochemical, cognitive outcomes and psycho-social aspects. the study uses a multidisciplinary approach, has a 3-year duration, and includes 3 follow-up phases. participants will be assigned to: a) experimental group, which will undergo a multimodal intervention for improving cognitive outcomes, functional status and mobility. treatment will include sessions of adapted tango, music therapy, engagement in social activities, comprehensive cognitive intervention and psycho-education for 6 months; or b) control group, which will receive psycho-education and advice on healthy life-style for 6 months. cognitive and psycho-social outcomes, functional, cardiovascular status, life-style characteristics, biochemical determination, will be evaluated at baseline and longitudinally. our hypothesis is based on expectation that the proposed could improve cognitive, functional outcomes and quality of life, with a positive impact on prevention of onset of dementia and cognitive decline in mci subjects.

Eligibility criteria:
inclusion criteria: * diagnosis of mild cognitive impairment * presence of a caregiver * capability to sign the informed consent exclusion criteria: * diagnosis of dementia * serious medical and/or psychiatric conditions

Keywords: mild cognitive impairment adapted tango dancing elderly people music therapy psycho-education
development of a practical, minimally invasive seizure gauge

Conditions: Epilepsy

Summary: the researchers are trying to assess changes in physiological signals before and during seizures.

subjects that are undergoing video eeg monitoring in the hospital for their epilepsy at mayo clinic will be consented to participate in this study for a minimum of two days and/or the duration of their hospital stay for their clinical care. subjects will be asked to wear up to 4 different commercially available seizure detection devices and complete surveys. in the second year of the study patients who have implanted devices capable of recording or detecting seizures will be recruited to wear a noninvasive biosensor for multiple months. this data will be used to develop algorithms capable of detecting and/or forecasting seizures. when the subjects clinical eeg monitoring is completed data scientists will analyze the data to identify patterns.

Eligibility criteria:
inclusion criteria: * patients with epilepsy- scalp eeg or invasive eeg monitoring for clinical care, or an implanted device capable of monitoring brain activity and identifying seizures (e.g. neuropace rns, medtronic pc+s, medtronic rc+s) * pediatric subjects 7 years of age or older. exclusion criteria: * cognitive or psychiatric condition rendering patient unable to cooperate with data collection, or manage and recharge smart watch and tablet computer devices. * presence of open or healing wounds near monitoring sites (infection risk).

Keywords: seizure
field implementation of idetect

Conditions: Concussion; Brain Trauma

Summary: the purpose of this study is to assess a new screening tool for sideline evaluation of concussion injuries in athletes. idetect is a new technology that combines several elements of recommended concussion screening tools into a single, portable device.

the goal of the research is to evaluate the use of a multimodal platform (idetect) for immediate post-injury neuropsychological, balance and oculomotor assessment, and to evaluate the idetect platform as a return-to-play assessment tool during the post injury management period following concussion.

Eligibility criteria:
inclusion criteria: * athletes participating in the fall 2015 high school season * aged 14 years or older * no concussion injuries within prior 2 months * provide signed and data consent and/or assent form(s) exclusion criteria: * non-english speaking * history of seizures or prior brain surgery (excluding facial and tm surgery) * concussion within last 2 months * poor effort on baseline idetect test non-collision sport group * current concussion or history of current concussion during the fall 2015 athletic season
a retrospective observational study to assess the impact of co-morbidities on treatment response in inflammatory bowel disease

Conditions: Inflammatory Bowel Disease

Summary: the purpose of this study was to evaluate the impact of the co-morbidities profile on treatment response to biological therapy in inflammatory bowel disease (ibd) participants.

this was a retrospective, non-interventional, observational study that included participants diagnosed with ulcerative colitis (uc) or crohn's disease (cd) who started treatment with biologics between june 2011 and june 2013. the study looked at the impact of the co-morbidities on the treatment response in ibd participants. the study enrolled 310 patients included both uc and cd patients. this multicenter trial was conducted in spain. investigator collected retrospective data in a single visit from participants who started biologic treatment between june 2011 and june 2013. time since participants started biological treatment until study visit or until lack of treatment response or until treatment change constituted the reference period for the study.

Eligibility criteria:
inclusion criteria: * adult participants (aged ≥18). * were diagnosed with uc or cd according to the "world gastroenterology organization practice guidelines for the diagnosis and management of inflammatory bowel disease (ibd) in 2010". * who were naive to biologics that started treatment with biologics between june 2011 and june 2013. * participants in whom biological treatment was prescribed according to clinical practice. * who gave written informed consent. exclusion criteria: * were participating in a clinical trial during the study reference period. * participant that, according to investigator's criteria was not capable to understand and fill in the study questionnaires or to give written informed consent.

Keywords: drug therapy