Kornimate/medical-research-clean huggingface dataset:
the effect of intravitral injection of triamcinolone combined with cataract surgery (phacoemulsification) on diabetic macular edema and diabetic retinopathy

Conditions: Diabetic Retinopathy

Summary: in this study, regressed proliferative diabetic retinopathy, very severe, severe and moderate non-prolifrative diabetic retinopathy patients who were going to have a cataract surgery, underwent a complete eye examination, oct, fag and color photography 2 weeks prior to their operation. all patients divided in two: 1) control group (phyco,pciol), 2) triamcinolone treatment group (phaco with pciol+ivt). one month after surgery a complete eye examination will be done especially; iop and endophthalmitis. a 6 month follow-up will be done for these two groups and diabetic retinopathy progression will be checked.


Eligibility criteria:
inclusion criteria: * diabetic patients with non-proliferative diabetic retinopathy and regressed pdr exclusion criteria: * uncontrolled htn * history of glaucoma * active pdr * nvi * trd * any ophthalmic operation * renal problem(cr\>3) * cva * uveitis

Keywords: triamcinolon cataract diabetic retinopathy non-proliferative retinopathy
hyperglycemia in a coronary intensive care unit

Conditions: Diabetes Mellitus; Hyperglycemia; Blood Glucose; Myocardial Ischemia

Summary: newly diagnosed hyperglycemia (ndh) and stress hyperglycemia (sh) during acute illness is reported as a non-physiological condition in hospitals. the investigators aim is to determine the rate of ndh and sh among cases admitted to coronary icu with acute coronary disease and to inquire the relationship of sh with disease severity and functional outcomes such as longevity of icu stay.

patients with acute coronary heart disease admitted to the emergency room will be recruited consecutively. admission plasma glucose (apg) and fasting plasma glucose (fpg); the first morning after admission, measurements will be obtained and each participant will be subjected to capillary glucose measurement (cgm) every six hours within the first day. patients will be separated into 4 groups: group 1: normoglycemic cases group 2: newly diagnosed hyperglycemic cases group 2a: unrecognized diabetes, hba1c: \>6.0% group 2b: stress hyperglycemia \<6.0%. group 3: known diabetes age, gender, co-morbidities on admission, adverse outcomes in hospital, duration of stay in coronary icu, deaths, drugs, and glucose levels will be all recorded. throughout the hospital stay of group 2 and group 3, cgms were performed and treated when necessary (target glucose\<180mg/dl). acute physiology and chronic health evaluation ii (apache-ii); a severity of disease classification system was used for each case.

Eligibility criteria:
inclusion criteria: * patients with acute coronary syndrome (non st segment elevation)and myocardial infarction admitted to coronary icu only via emergency room exclusion criteria: * patients admitted to coronary icu from other hospital wards * patients with any disease that will need drugs that may interfere with blood glucose negatively (mannitol, glucocorticoids, vasopressor agents, etc.)
studying genes in samples from younger patients with desmoplastic small round cell tumor registered on cog-d9902 or cog-abtr01b1

Conditions: Sarcoma

Summary: rationale: studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in dna and identify biomarkers related to cancer. purpose: this research study is studying genes in samples from younger patients with desmoplastic small round cell tumor registered on cog-d9902 or cog-abtr01b1.

objectives: * to perform whole-exome sequencing on desmoplastic small round cell tumor (dsrct) samples and their available matched normal samples to identify novel mutations, single nucleotide polymorphisms, or copy number changes associated with these tumors. * to identify regions of interest that may be involved in the pathogenesis (including the region of ewsr1-wt1 translocation) from the whole-exome sequencing and perform detailed resequencing and transcriptone sequencing to further define the molecular aberrations at the rna level. outline: this is a multicenter study. archived tumor tissue samples are analyzed for dna sequencing, effects of rna on gene expression levels, novel rna isoforms, splice variants, and translocations.

Eligibility criteria:
disease characteristics: * tumor and blood samples from patients registered on cog-d9902 or cog-abtr01b1 obtained from the cooperative human tissue network (chtn) and the children's oncology group (cog) tumor banks * matched normal samples patient characteristics: * not specified prior concurrent therapy: * not specified

Keywords: childhood desmoplastic small round cell tumor metastatic childhood soft tissue sarcoma nonmetastatic childhood soft tissue sarcoma recurrent childhood soft tissue sarcoma recurrent adult soft tissue sarcoma stage i adult soft tissue sarcoma stage ii adult soft tissue sarcoma stage iii adult soft tissue sarcoma stage iv adult soft tissue sarcoma adult desmoplastic small round cell tumor
noninvasive blood glucose monitoring using otoacoustic emissions

Conditions: Diabetes

Summary: the purpose of the research is to determine whether a noninvasive hearing test may be used to predict blood glucose in people with diabetes.

participation in the study will involve listening to sounds through earphones while blood glucose levels are measured by taking blood samples using a lancet. during the study, blood glucose levels will be increased by drinking a beverage containing sugar. up to five visits to the ncrar will be needed over a six-month period to complete the study. each visit lasts either two or four hours, and will be scheduled at your convenience. you will be paid $20 for the first 2-hour screening visit and $50 for each 4-hour visit. you will be paid $30 if you are selected to participate in a 2-hour attention correlation test that a sub-set of 10 participants will complete.

Eligibility criteria:
inclusion criteria: * 18 years or older * diabetes * normal hearing * hemoglobin a1c of 5.5-8% exclusion criteria: * volunteers may not participate if they have peripheral neuropathy * visual impairment due to diabetic retinopathy * organ failure (kidney, liver heart, or lungs) * severe or unstable cardiovascular disease * active alcohol or drug abuse * schizophrenia * bipolar disorder * active major depressive disorder * active foot ulcerations * active viral or other infections such as hiv * hepatitis, or pneumonia * serious renal * cardiac or cognitive dysfunction.

Keywords: diabetes
are patients suffering from dsps show compromising in everyday functions and abilities before handling the disorder?

Conditions: Delayed Sleep Phase Syndrome

Summary: the purpose of this study is to determine whether the known treatment for dsps also improve the cognitive ability and mood of the patients.

every participant will take a few test and tasks that are going to test his cognitive ability and mood before treatment in 08:00 and 20:00, and again the same tests at the same hours after the treatment.

Eligibility criteria:
inclusion criteria: * diagnosed with dsps exclusion criteria: * attention deficit hyperactivity disorder - diagnosed, affective disorder- diagnosed
prevalence of different etiologies of ocular dryness in patients previously diagnosed with dry eye disease in a sample of egyptian patients

Conditions: Dryness; Dry Eye Syndromes; Meibomian Gland Dysfunction

Summary: proposed study title: prevalence of different etiologies of ocular dryness in patients previously diagnosed with dry eye

dry eye disease (ded) is a common chronic multifactorial condition of the ocular surface characterized by failure to produce high quality or sufficient amounts of tears to moisturize the eyes (1) ded can be categorized as "dry eye with reduced tear production (aqueous deficient) and dry eye with increased evaporation of the tear film known as the hyperevaporative type... although 10% of individuals have aqueous deficient ded, more than 80% have either the hyperevaporative type related to meibomian gland dysfunction (mgd), or a combination of

Eligibility criteria:
inclusion criteria: * egyptian people between 20 and 70 years old coming to outpatient clinic but\< 10 seconds.. no previous surgery. no previous trauma. not using eye drops in the last 3 months. exclusion criteria: diabetic patients. patients with rheumatological diseases that may affect ocular surface as ra.

Keywords: dry eye disease
study to evaluate the bronchoprotective effects of a single dose of n6022 in patients with mild asthma

Conditions: Asthma

Summary: the purpose of this study is to determine whether a single iv dose of n6022 will have a significant bronchoprotective effect, compared with placebo, during methacholine challenge.

the number of patients with adverse events measured in both the treated and placebo groups from start of dosing until day 28 post dose.

Eligibility criteria:
inclusion criteria: * body mass index (bmi) between 18.5 and 35 kg/m2, inclusive, at screening. * patient has a ≤ 5 pack years smoking history and nonsmoking for ≥ one year. * documented history of mild bronchial asthma, first diagnosed at least 6 months and currently being treated only with intermittent short-acting beta-agonist therapy by inhalation. * pre-bronchodilator fev1 ≥ 75% of predicted at screening. * sensitivity to methacholine with a provocation concentration of methacholine resulting in a 20% fall in fev1 (pc20 methacholine) of ≤ 8 mg/ml at screening. * demonstrated stable lung function during screening with ≤10% variability between two assessments of fev1 taken at least 7 days apart at approximately the same time of day. exclusion criteria: * hypertension at screening is defined as systolic blood pressure (bp) \>150 mmhg or diastolic bp \> 90mmhg. * respiratory tract infection and/or exacerbation of asthma within prior 4 weeks * history of life-threatening asthma * administration of steroids within 4 weeks of the screening visit. * history of being unable to tolerate or complete mch testing. * blood donation (500 ml) within 3 months of starting the clinical study. * tested positive for hepatitis c antibody or hepatitis b surface antigen. * tested positive for human immunodeficiency virus (hiv) antibodies.
cognitive behavioural therapy-informed groups for psychosis

Conditions: Psychosis

Summary: this is a feasibility study of cognitive behavioural therapy-informed groups for psychiatric inpatients with positive symptoms of psychosis.

the majority of inpatients at parkwood institute mental health have symptoms of psychosis. in line with health quality ontario standards for the treatment of psychosis, the investigators would like to implement and evaluate cognitive behavioural therapy for psychosis (cbtp) informed groups. the feasibility, acceptability, and preliminary efficacy of cbtp groups for inpatients will be examined. pragmatically, the investigators propose to undergo training in cbtp, implement empirically-supported cbtp protocols developed for inpatients, track outcomes, and publish our findings. the investigators would also incorporate patient feedback to improve future iterations of the protocol. such an undertaking would build research capacity in front line staff by encouraging engagement in cbtp group training, survey design, participant screening, data collection, analyses, and dissemination of findings.

Eligibility criteria:
inclusion criteria: * can read/write in english * has positive symptoms of psychosis that are distressing to them exclusion criteria: * inability to tolerate group participation

Keywords: cognitive behavioral therapy
evaluation of the avaulta procedure for the correction of pelvic organ prolapse - results at 1 year

Conditions: Pelvic Organ Prolapse

Summary: this study is a 1 year review of all patients who had surgery to correct pelvic organ prolapse (i.e. cystocele, rectocele, enterocele) using the avaulta synthetic mesh kit.

this is a retrospective cohort analysis of all patients who experienced vaginal prolapse and were operated on with the avaulta synthetic vaginal mesh "kit" from january 2006 to april 2007. the avaulta synthetic mesh is composed of polypropylene which is a monofilament. the objective of this trial is to compare patients objectively and subjectively at least one year after placement of the avaulta synthetic vaginal mesh in terms of prolapse symptoms. this data will be compared to pre-operative data already collected for these patients as a part of their routine surgical work-up. mesh-related complications will be quantified, including erosions, new-onset pain, and infections. success and anatomic recurrence rates will be recorded as well

Eligibility criteria:
inclusion criteria: * all patiall patients who underwent surgery with the avaulta synthetic mesh kit from 1/06 - 4/08. exclusion criteria: * unable to give informed consent to participate

Keywords: pelvic organ prolapse cystocele rectocele enterocele synthetic mesh vaginal mesh transobturator
impact of vitamin c on pain detection and tolerance threshold

Conditions: Pain, Acute

Summary: non-opioid treatments are increasingly sought after for managing acute pain. non-steroidal anti-inflammatory drugs (nsaids) (e.g., advil, motrin, naproxen) combined with acetaminophen (e.g., tylenol) have become an alternative for relieving acute pain. however, many patients cannot tolerate or have contraindications to nsaids and acetaminophen. there is therefore an urgent need for studies evaluating the analgesic effects of vitamin c in the context of acute pain. our study is conducted with healthy volunteer participants receiving either vitamin c or a placebo to assess the analgesic effect of vitamin c by comparing pain detection and tolerance thresholds.

opioid-free treatments are increasingly sought for acute pain and nsaids have become an alternative to treat acute msk pain and are often administered in addition to acetaminophen. however, nsaids can produce important adverse events and are contraindicated in many patients with comorbidities (e.g., heart disease, renal failure). similarly, acetaminophen is contraindicated in patients with active liver disease or severe hepatic impairment. vitamin c has shown opioid sparing and anti-inflammatory effects mostly in postoperative contexts. vitamin c has also demonstrated very low toxicity and rare contraindications at the dosage used in this study. demonstrating that vitamin c increases pain detection and tolerance thresholds, thereby exhibiting an analgesic effect, could offer a valuable alternative or adjunct for patients who cannot tolerate or have contraindications to nsaids or acetaminophen, helping to reduce opioid use. with an aging population, the number of affected patients is expected to rise significantly. the primary outcome is the pressure pain detection threshold (ppdt) measured with an algometer one to three hours after the last dose of the study drug (24 hours after the first dose of vitamin c or placebo). secondary outcomes are ppdt one to three hours after the first study drug dose, pptt one to three hours after the initial dose and last dose of the study drug, and adverse events from the algometer or the vitamin c.

Eligibility criteria:
inclusion criteria: 1. age ≥ 18 to 65 years old; 2. no acute or chronic pain; 3. no pain medication; 4. french or english-speaking exclusion criteria: 1. currently using vitamin c supplements; 2. pain in the last week or active cancer; 3. unavailable for follow-up; 4. allergy to milk (lactose in the placebo), or vitamin c, 5. treated with cyclosporine or warfarin (interaction with vitamin c); 6. pre-existing oxalate nephropathy, liver cirrhosis or hemochromatosis; 7. evidence of joint or overlying skin infection in the areas of testing.

Keywords: vitamin c algometer pain detection pain threshold
evaluation of treatment safety in patients with atrial fibrillation on edoxaban therapy in real-life in turkey

Conditions: Atrial Fibrillation

Summary: this is a national, multi-center, prospective study to evaluate the safety of edoxaban in patients diagnosed with af who are currently using edoxaban for stroke prevention. the primary objective: * to evaluate safety of edoxaban treatment in patients with atrial fibrillation (af) on edoxaban therapy in routine clinical practice in turkey.

edoxaban was recently approved by the turkish medicines and medical devices agency for the prevention of stroke and systemic embolism in adult patients with nonvalvular atrial fibrillation (nvaf) with one or more risk factors, such as congestive heart failure, hypertension, diabetes mellitus, prior stroke or transient ischemic attack (tia). treatment of deep vein thrombosis (dvt) and pulmonary embolism (pe) and prevention of recurrent dvt and pe in adults. the study will evaluate the safety of edoxaban in patients diagnosed with af who are currently on edoxaban therapy for prevention of stroke in routine clinical practice in turkey for stroke prevention up to 1 year following treatment by specialized as well as non-specialized physicians in hospital centers.

Eligibility criteria:
inclusion criteria: * atrial fibrillation (af) patients aged 18 years or above who are currently using edoxaban for prevention of stroke. * has provided written informed consent to participate in the study. exclusion criteria: * not on edoxaban therapy on the date of obtaining informed consent * receiving edoxaban therapy for an indication other than the relevant indication (stroke prevention in af) * participating in another ongoing clinical study will also be excluded.

Keywords: edoxaban atrial fibrillation nonvalvular atrial fibrillation (nvaf) non-vitamin k oral anticoagulants (noacs) real world evidence (rwe) turkey
the role of mechanical diagnosis and therapy in the management of concussion

Conditions: Brain Concussion; Mild Traumatic Brain Injury

Summary: the purpose of this study is to examine the role of a mechanical diagnosis and therapy (mdt) examination in identifying participants diagnosed with concussion who display a directional preference compared to who don't display a directional preference.

directional preference describes the clinical phenomenon where a specific direction of repeated movement and / or sustained position results in a clinically relevant improvement in symptoms. this improvement is usually accompanied by an improvement in function or mechanics or both. its presence and relevance is determined over 2-3 visits. this study aims to identify the proportion of participants with concussion who present with a directional preference during the course of physical therapy. a secondary aim of this study is to investigate whether directional preference is associated with the eventual patient related outcomes following care.

Eligibility criteria:
inclusion criteria: * age = 13 - 65 * complaints of neck pain, headache, or dizziness associated with a diagnosis of concussion or mild tbi * ability to read/write english * referral from physician exclusion criteria: * age less than 13 or greater than 65 * cause of symptoms is result of a work-related accident or motor vehicle accident * receiving concurrent treatment from a chiropractor or massage therapist * glasgow coma scale less than 12 * lesion on head ct/mri * focal neurological deficits associated with serious spinal pathology (fracture, infection, tumor, vertebrobasilar insufficiency) * inability to or unwilling to exercise as part of usual pt care * unable to read/write english * history of osteopenia/osteoporosis or cancer

Keywords: mechanical diagnosis and therapy directional preference repeated movements
validation of the preschool confusion assessment method for the intensive care unit (pscam-icu)

Conditions: Delirium; Cognitive Impairment

Summary: the investigators hypothesize that critical care trained registered nurses and physicians can perform measurements of cognitive impairment in critically ill pediatric patients in a reliable and valid manner. to test this hypothesis, the investigators will incorporate an instrument (pscam-icu) to assess both components of consciousness, arousal and content, in critically ill pediatric patients at least 6 months to children 5 years of age, both on and off mechanical ventilation, and compare these assessments to those of the reference standard.


Eligibility criteria:
inclusion criteria: * all patients admitted to the pediatric critical care unit regardless of admitting diagnosis aged at least 6 months of age up to 5 years of age. * patients ventilated or non-ventilated. exclusion criteria: * non-english speaking patients. * children with visual or hearing impairments. * patient/surrogate or physician refusal * moribund and not expected to survive \>48 hours * patients in whom comfort care orders have been instituted * patients who are identified for transfer to floor or home regardless of placed orders or bed availability
psychiatric care via videoconferencing

Conditions: Depression

Summary: the purpose of this project is to compare the effectiveness between face-to-face consultations and consultations via videoconferencing among patients treated in the institute of psychiatry (ipq).

introduction: within the emergence of the internet and for the purposes of providing psychiatric services across distances, the provision of mental health service via video counseling has become a possible way of mental health service delivery. an appropriate systematization of the propaedeutic methods in psychiatry, according to the interactive resources of telemedicine, and a standardized assessment based on clinical records turn this method to a viable alternative for service delivery all over the world. the main benefit of video counseling is an increased access to care services. but, so far, there is still limited research regarding to the effectiveness of telepsychiatry in the management of mental illnesses. objective: to verify the applicability of psychiatric attendance via interned-based videoconferencing, comparing various quality characteristics between this method and face-to-face attendance, on the basis of a one-year follow-up study with a randomized clinical trial (rct) design. material and methods: 100 patients of the institute of psychiatry (ipq) between 18 to 55 years old with depressive disorders are randomly allocated to a control (monthly face-to-face consultation with the attending psychiatrist) or intervention group. the intervention group will have consultations with the attending psychiatrist through internet-based videoconference. for reasons of patient safety, consultations at baseline, and after 6 and 12 months will be realized in a face-to-face form for all patients. at baseline, and after 6 and 12 months mental health, satisfaction with treatment, therapeutic relationship, and medical compliance will be assessed. depression will be assessed at baseline, and after 3, 6, 9 and 12 months.

Eligibility criteria:
inclusion criteria: * depressive disorder * between 18 to 55 years * broadband internet access exclusion criteria: * hamilton depression rating scale total score \> 15 * severe cognitive limitations

Keywords: telepsychiatry telemental health teleassistance health care delivery depression telemedicine remote consultation videoconferencing community mental health services