Kornimate/medical-research-clean huggingface dataset:
monopolar electrosurgery versus ultrasound scissors in thoracoscopic ventral spondylodesis

Conditions: Fractures of Vertebral Bodies

Summary: this study was undertaken to investigate the effect of using ultrasound scissors in the preparation for thoracoscopic ventral spondylodesis. quantity of bleeding and the duration of operation in thoracoscopic ventral spondylodesis are compared to the preparation with monopolar electrosurgery.

one group of patients will be operated on using ultrasound scissors in the preparation during thoracoscopic ventral spondylodesis. the other group will be operated on using monopolar electrosurgery. the study is designed as a randomized trial. that means that all patients who have given their consent to participate in the study will be allocated to either ultrasound scissors or monopolar electrosurgery by chance. a total of 40 patients will be included in this study. the study ends with finishing of the first day after the operation, there is no longer follow up.

Eligibility criteria:
inclusion criteria: * informed consent * fracture of vertebral bodies th10-l2 with indication for operative treatment exclusion criteria: * missing informed consent * mission indication for operative treatment * revision of the trailing edge * clotting inhibition therapy * asa iii/iv * pregnancy * malfunction of liver child c

Keywords: fractures of vertebral bodies th10-l2 (ao a1 with kyphosis, a2.3, b or c-type)
supar in the early diagnosis of acute kidney injury(aki) after on-pump cardiac surgery

Conditions: Acute Kidney Injury

Summary: acute kidney injury(aki) is of the serious complications in patients with undergoing on-pump cardiac surgery. end stage kidney failure requiring dialysis therapy after cardiac surgery is associated with more than 60% mortality rate. involvement of aki after on-pump cardiac surgery increases the mortality rate 19 times. supar is one of the novel biomarker which has potential prognostic value for renal dysfunction in patients with undergoing on-pump cardiac surgery. early diagnosis and prompt intervention to prevent aki has great importance for management of postoperative cardiac patients.


Eligibility criteria:
inclusion criteria: * approved informed concent age higher than 18 years old exclusion criteria: * chronic kidney disease renal transplantation cancer history previous cardiac surgery sepsis liver failure thyroid dysfunction having long term steroid therapy having renal replacement therapy exposure to nephrotoxic drug and radiocontrast substance before 5 days of surgery diagnosis of acute kidney injury intraaortic balloon or extracorporeal membrane oxygenation insertion after surgery

Keywords: supar acute kidney injury on-pump cardiac surgery biomarker
an efficacy study to evaluate alfuzosin to treat men with erectile dysfunction and mild lower urinary tract symptoms

Conditions: Erectile Dysfunction; Lower Urinary Tract Symptoms

Summary: the purpose of this study is to assess the effect of alfuzosin in treating erectile dysfunction in men with mild lower urinary tract symptoms based upon a change from baseline in erectile function (ef) domain of international index of erectile function (iief).

this protocol is a placebo-controlled, double-blind, crossover trial. patients will be screened and then randomized to group a or group b at a 1:1 ratio to receive a placebo tablet once daily or alfuzosin (10 mg) daily for 12 weeks. patients will then crossover with the original placebo group receiving alfuzosin for 12 weeks and the original alfuzosin group receiving placebo. at every visit the patients will complete an iief and an aua symptom index.

Eligibility criteria:
inclusion criteria: * male, 30-69 years of age * has mild to moderate erectile dysfunction with a score \< 25 on ef domain in iief * aua score of less than or equal to 14 * negative urinalysis with no evidence of a urinary tract infection exclusion criteria: * blood pressure \ 170/110 * neurological disorder (ms, sci, cva, parkinson's disease, als) * diabetes mellitus * history of psa \> 10 * history of confirmed or suspected prostate cancer * history of moderate/severe hepatic insufficiency defined as \> 2x uln * on alpha blocker or pde 5 inhibitor within 2 weeks of randomization * receive treatment with other investigational agents within 30 days prior to enrollment
metabolic profiling of hematopoietic stem cells in clonal hematopoiesis (chip)

Conditions: Osteoporosis; Osteoarthritis, Hip; Hip Fractures; Clonal Hematopoiesis of Indeterminate Potential; Aging

Summary: bone marrow samples will be collected from patients undergoing hip arthroplasty surgery. blood and bone marrow samples will be used for metabolic profiling and analysis of relevant chip mutations. combined single-cell transcriptomics and mutation-specific single-cell genotyping (biotin-pcr using mutation-targeted primers followed by sequencing) will subsequently be performed. the gene expression profile of wildtype and mutant hematopoietic stem cells will be compared, performing both broad gene set enrichment analysis and targeted analysis of metabolic pathways.


Eligibility criteria:
inclusion criteria: * age 65 years and older exclusion criteria: * known haematological condition (myelodysplasia, leukemia, cancer) * inability to provide written informed consent
change in ocular flora resistance from repeated topical antibiotic use

Conditions: Increased Drug Resistance; Infection Resistant to Quinolones and Fluoroquinolones

Summary: the purpose of this study is to determine if antibiotic resistance of the ocular surface flora to the 4th generation fluoroquinolones will increase after repeated use of topical antibiotics for three days post intravitreal injection.

treatment with intravitreal (ivt) injections has increased during the last several years as evidence has accumulated demonstrating the efficacy of anti-vascular endothelial growth factor agents in the treatment of neovascular age-related macular degeneration (amd) and various retinal vascular diseases. although ivt injections are generally safe, infectious endophthalmitis is a rare but devastating complication, and the risk of morbidity and vision loss from endophthalmitis is high. the objective is to examine the change in antibiotic resistance of ocular surface flora with repeated prophylactic use of antibiotics after ivt injection for amd. yin, v. t., weisbrod, d. j., eng, k. t., schwartz, c., kohly, r., mandelcorn, e., lam, w., daneman, n., simor, a., \& kertes, p. j. (2013). antibiotic resistance of ocular surface flora with repeated use of a topical antibiotic after intravitreal injection. jama ophthalmology, 131(4), 456-461.

Eligibility criteria:
inclusion criteria: * patients scheduled for intravitreal injection for neovascular age-related macular degeneration (armd) * 65 years or older * able to provide informed consent. exclusion criteria: * diagnosed with an active ocular, periocular or systemic infection * previously received treatment with an intravitreal injection * previously treated with antibiotics in the past three months * unable to attend the scheduled follow-up appointments or to complete treatment for any reason
a randomized, two-arm, open label study to evaluate the effect of a smart phone-based patient support tool on patient adherence of treatment in stable angina patients prescribed beta-blockers in china (support)

Conditions: Adrenergic Beta-Antagonists; Stable Angina Pectoris; Medication Adherence; Mobile Applications

Summary: the present study aims to enhance the adherence of beta-blockers by patient support tool through a smart phone application and a wristband, subsequently reduce the risk of angina attacks in patients with stable angina pectoris.

to control heart rate in terms of guidelines in patients with stable angina pectoris reduces risk of cardiovascular events, rehospitalization, and death effectively. using beta blockers is an efficient therapy to management the hr in sap patients. however, the recent epidemiological studies have provided evidences that the rate of beta blocker prescribed and used was inadequate, as the first-line therapy to cad patients with the usage rate less than 30%. several studies showed that with a reminder supported by smart phones and wearable devices, the adherence of management of patients with chronic disease could be improved significantly.thus,the present study aims to enhance the adherence of beta-blockers by patient support tool through a smart phone application and a wristband, subsequently reduce the risk of angina attacks.

Eligibility criteria:
inclusion criteria: 1. aged 18-70 years; 2. stable angina pectoris; 3. indicated for beta blockers; 4. hr ≥ 60bpm; 5. patient must have a smart phone that is compatible with the patient support tool at their disposal and are comfortable with using of interactive smart phone applications. the required specification for the phone will be determined after completed testing; 6. ability to read, understand and write chinese; 7. beta-blockers naïve or with no beta-blocker use during the last 1 month. exclusion criteria: 1. previous myocardial infarction during the recent 1 year; 2. cardiac shock or unstable heart failure (nyha iii); 3. sbp\<100 mmhg; 4. sick sinus syndrome; 5. ii-iii degree atrioventricular block; 6. existing contraindication for beta-blockers or allergic to beta-blockers; 7. participation in another clinical study with a beta blocker during the last 3 months; 8. inability to sign the informed consent form; 9. females during pregnancy and lactation and women of child bearing potential planning to be pregnant within 24 weeks.; 10. patients who withdraw from this study for any reason cannot re-enter the study; 11. life expectancy \< 1 year; 12. severe asthma or copd; 13. severe peripheral vascular disease;

Keywords: beta-blocker stable angina pectoris patient support tool adherence
wheeled mobility for preventing pressure ulcers

Conditions: Mobility Limitation

Summary: the proposed clinical trial is aimed at demonstrating the important role wheelchairs play in preventing pressure ulcers (bed sores). although most pressure ulcers can be prevented, they are common in nursing home settings because their causes are difficult to identify. this clinical trial will guide practitioners toward improving preventive care practices by demonstrating how to effectively apply wheelchair and seat cushion technology.

pressure ulcers are a significant healthcare problem for the growing number of nursing home residents in the united states and around the world. pressure ulcers diminish quality of life, exact a devastating loss of function, increase the risk of death in geriatric populations and raise healthcare costs. costs for the management of pressure ulcers in the us likely exceeds $6.4 billion annually, with a prevalence of approximately 12% in the high risk ltc population. a previous clinical trial at the university of pittsburgh studied the effects of seat cushions on pressure ulcer incidence and found that when a skin protection seat cushion is used with a properly fitted wheelchair there is a significant reduction in incidence. the data led the investigators to question whether having a properly fitted wheelchair also has a significant effect on pressure ulcer incidence. this clinical trial investigate this question by randomizing subjects into a control group that receives a skin protection cushion and wheelchair training for use in their facility supplied wheelchair, or a treatment group that receives a skin protection cushion, wheelchair training and a new custom-fitted wheelchair. we expect that the treatment group will have a lower incidence of pressure ulcers.

Eligibility criteria:
inclusion criteria: 1. male or female nursing home resident 60 years of age and older 2. a braden score of less than or equal to 18 3. a combined braden activity and mobility subscale score less than or equal to 5 4. absence of ischial and sacral area pressure ulcers (see definition of pressure ulcer) 5. a tolerance for total daily wheelchair sitting time of greater than or equal to 6 hours (not continuous) 6. ability to accommodate seating and positioning needs with the wheelchair selected for use in this study (breezy ultra 4) 7. informed written consent exclusion criteria: 1. body weight exceeding 250 lbs. 2. hip width exceeding 20 in. 3. wheelchair seating requirements for additional head support, seat depth \> 20 inches, elevated leg rests or severe orthopedic deformities of the pelvis, lower extremities or back that exceed the accommodating capability of the breezy ultra 4 wheelchair. 4. current use of any cushioning material(s) other than a standard cushion, a folded pad, or a pillow (standard cushion as defined by hcpcs code for standard cushions, i.e., non-skin protection cushion) 5. current use of a hcpcs code k0004 wheelchair

Keywords: pressure ulcers wheelchairs wheelchair functional capacity custom-fitted wheelchair
prospective study of pain after spinal morphine for cesarean section and factors involved in moderate to severe pain

Conditions: Pain, Postoperative

Summary: spinal block with intrathecal morphine is a popular anesthetic technique in cesarean delivery. this technique brings about good maternal and neonatal outcomes as well as provides good postoperative pain control. systematic review showed intrathecal morphine produced long period of pain control up to 27 hours. however, some patients still experienced moderate to severe pain which defined as postoperative pain score \>,= 4. from our institute survey, there were more than 50 percents of patients undergoing cesarean delivery receiving spinal block with intrathecal morphine experienced moderate to severe pain in the first 24 hours. the aim of the study is to determine the actual incidence and associated factors of patients whom experienced moderate to severe pain after spinal anesthesia with intrathecal morphine 200 mcg in cesarean delivery.

spinal block with intrathecal morphine is a popular anesthetic technique in cesarean delivery. this technique brings about good maternal and neonatal outcomes as well as provides good postoperative pain control. systematic review showed intrathecal morphine produced long period of pain control up to 27 hours. however, some patients still experienced moderate to severe pain which defined as postoperative pain score \>,= 4. from our institute survey, there were more than 50 percents of patients undergoing cesarean delivery receiving spinal block with intrathecal morphine experienced moderate to severe pain in the first 24 hours. failure in achieve adequate pain control results in poor maternal satisfaction, effect breast feeding and may lead to chronic wound pain. the aim of the study is to determine the actual incidence of patients whom experienced moderate to severe pain after spinal anesthesia with intrathecal morphine 200 mcg in cesarean delivery. also, factors that may involved moderate to severe postoperative pain will be analyzed and reported.

Eligibility criteria:
inclusion criteria: * age \> 18 years * elective cesarean section * patient accept spinal anesthesia * asa classification i-ii * understand numerical rating scale for pain score exclusion criteria: * not understand thai * contraindicated in spinal anesthesia with intrathecal morphine * complicated pregnancy that general anesthesia may required for cesarean delivery

Keywords: pain, postoperative cesarean delivery intrathecal morphine
observational study to assess maternal, fetal and infant outcomes following exposure to rimegepant

Conditions: Migraine

Summary: the purpose of the study is to evaluate fetal, maternal, and infant outcomes through 12 months of age.


Eligibility criteria:
inclusion criteria: * pregnant women with migraine exposed to rimegepant: a diagnosis of migraine and at least 1 dose of rimegepant during pregnancy or just prior to pregnancy (up to 3 days prior to conception) * pregnant women with migraine unexposed to rimegepant: a diagnosis of migraine and no exposure to rimegepant before or during pregnancy exclusion criteria: • women exposed to other calcitonin gene-related peptide (cgrp)antagonists (e.g., ubrogepant), cgrp monoclonal antibodies, or ditans (e.g., lasmiditan) at any time during pregnancy or just prior to pregnancy

Keywords: migraine, migraine headache, pregnant, pregnancy, infant
clinical study of the safety of menhycia® in 3-month-old infants

Conditions: Epidemic Meningitis

Summary: this study is an open, multicenter phase iv clinical study to evaluate the safety of vaccination with menhycia®. the study plan is to enroll approximately 3,000 infants at 3 months of age who have not been vaccinated with any epidemic encephalitis vaccine, and to administer a total of 3 doses of menhycia®, with a minimum of 1 month between doses, and a booster dose of 1 dose of immunization is allowed at 12 months of age.


Eligibility criteria:
inclusion criteria: * infants 3 months of age who had not received any epidemic encephalitis vaccine at the time of screening * the legal guardian or delegate has given informed consent, has voluntarily signed an informed consent form, and is able to comply with the requirements of the clinical study protocol exclusion criteria: first dose exclusion criteria * fever before vaccination, axillary temperature \>37.0°c * congenital malformations or developmental disorders, genetic defects, severe malnutrition, etc. * history of epilepsy, convulsions or seizures or history or family history of psychiatric disorders * acute infections or active chronic diseases, severe infectious or allergic skin diseases * known allergy to a component of the vaccine, especially to diphtheria toxoid, or to previous administration of the product * other circumstances that, in the judgment of the investigator, make participation in this clinical study inappropriate subsequent dose exclusion criteria * severe allergic reactions after a previous dose of vaccine * those with serious adverse reactions causally related to the previous dose of vaccination * other circumstances that, in the judgment of the investigator, make participation in this clinical study inappropriate

Keywords: vaccine acyw135 crm197 safety 3 months of age
telephone delivered weight loss, nutrition, exercise welnes study

Conditions: Obesity-Related Malignant Neoplasm

Summary: this phase iii trial compares telephone delivered acceptance and commitment therapy to standard behavioral therapy for improving weight loss in overweight or obese participants. acceptance and commitment therapy focuses on increasing willingness to experience physical cravings, emotions, and thoughts while making values-guided committed behavior changes. acceptance and commitment therapy may work better at improving weight loss compared to standard behavioral therapy.

outline: participants are randomized to 1 of 2 arms. arm i: participants receive act telephone coaching over the course of 12 months, calls 1-16 weekly, calls 17-23 biweekly, and calls 24-25 monthly. call 1 is 30 minutes in duration, while calls 2-25 are each 15-20 minutes in duration. arm ii: participants receive sbt telephone coaching over the course of 12 months, calls 1-16 weekly, calls 17-23 biweekly, and calls 24-25 monthly. call 1 is 30 minutes in duration, while calls 2-25 are each 15-20 minutes in duration. participants are followed up at 6, 12, and 24 months after randomization.

Eligibility criteria:
inclusion criteria: * overweight or obese (body mass index \[bmi\] \>= 27) but not heavier than bmi of 45.5 (measured by weight \& height) * wants to lose weight in the next 30 days * interested in learning skills to lose weight * willing to be randomly assigned to either condition * resides in united states (us) * has daily access to their own phone and email * does not have a medical or psychiatric condition that would limit their ability to comply with the behavioral recommendations of the program or pose a risk to the participant during weight loss, including meeting criteria for binge eating disorder, and meeting criteria for severe depression (cesd \>= 25), or a diagnosis of serious heart disease, diabetes, uncontrolled hypertension, or cancer without written confirmation of approval from their physician office * not pregnant, planning to become pregnant or breastfeeding in the next 12 months * in the past 3 months changed the dosage of prescription medications that can cause a significant change in weight or appetite * have not lost more than 5% of their weight in the past 6 months * willing and able to read in english * not participating in or planning to participate in other weight loss programs * has not participated in our other act intervention studies * does not meet criteria for combined heavy plus binge drinking * has access to a bluetooth-enabled device and wi-fi and/or data plan * is not planning to have or has not recently had (past 12 months) bariatric surgery * for outcome data retention, eligibility criteria included: willing to complete follow-up surveys, and provide email, phone, and mailing address exclusion criteria: * the reverse of the inclusion criteria
vale+tú salud: corner-based trial to test a latino day laborer program adapted to prevent covid-19

Conditions: COVID-19

Summary: the purpose of this study is to determine the cultural, socioeconomic, inter/personal and work-related factors that influence covid 19 mitigation practices including social distancing, hand-washing and personal protective equipment (ppe) use, to adapt, implement, and test vale+tú salud in a cluster randomized trial to assess the extent to which ldl report increased adherence with covid 19 mitigation practices 1 month post intervention and to promote vale+tú salud just-in-time results and increase its capacity to rapidly disseminate findings among groups that serve ldl and other latino immigrants.


Eligibility criteria:
inclusion criteria: * self-identify as hispanic or latino * be present at the corner for the purposes of looking for work exclusion criteria: * have not been previously hired to work at a corner * symptoms of covid-19 in the previous 48 hours

Keywords: latino day laborers
effect of cervical traction on balance in cervical radiculopathy patients

Conditions: Cervical Radiculopathy; Vertigo

Summary: a cross-over randomized trial aiming to assess the immediate effect of cervical traction on balance disorders among patients with common cervical neuropathy. authors hypothesized that as cervical traction alleviate radicular pain it may also improve patient balance disorders. effective traction is compared to sham traction. main outcome measures are balance parameters (force platform).

a cross-over randomized trial was designed to assess the immediate effect of cervical intermittent traction on balance disorders among patients diagnosed with common cervical neuropathy. the diagnosis is confirmed or made by a physical medicine and rehabilitation physician with 15 y of experience treating musculoskeletal disorders especially cervical neuropathy. enrolled patients are randomly assigned to one of two arms (1 or 2). patients in arm 1 (effective traction/sham traction) are treated firstly with effective traction than one week later with sham traction. patients in arm 2 (sham traction/effective traction) are treated firstly with sham traction than one week later with effective traction. at baseline the epidemiological parameters, the pain intensity (vas), the grip strength, the functional status (ndi), the psychological distress (had), the brief best test and the balance parameters (force platform) are assessed. the pain intensity, the grip strength and the balance parameters are assessed before and immediately after cervical traction for comparison.

Eligibility criteria:
inclusion criteria: * unilateral cervical radiculopathy of greater than three months exclusion criteria: * history of surgery or bone-ligament damage to the cervical spine * neurological and/or rheumatic diseases involving the cervical spine or which may result in impaired balance * inner ear and vestibular pathology * worsening of pain or intolerance in the manual cervical traction test

Keywords: cervical radiculopathy vertigo traction balance postural