Kornimate/medical-research-clean huggingface dataset:
pharmacogenetic analysis of korean pediatric patients with acute lymphoblastic leukemia

Conditions: Acute Lymphoblastic Leukemia

Summary: this study is to find out distribution of genetic polymorphisms and genes related to the chemotherapeutic drugs of all.

cure rate of pediatric all dramatically improved over 80%. resistance to drug and hematologic relapse are remaining problem in all treatment. one of the explanations of drug resistance and toxicities is the pharmacogenetic effect. germline polymorphisms in genes that code for proteins involved in the pharmacokinetics and pharmacodynamics of antileukemic agents are various, and inter-patient variability is the main factor for pharmacogenetic difference. since multiple chemotherapeutic agents are involved in treating all, many genes related to the metabolic pathways of those drugs have an effect on the pharmacokinetics of patients with all. in korea, pharmacogenetic study including multiple genetic loci for pediatric all has not been reported.in this study, the distribution of genetic polymorphisms and genes related to antileukemic drugs were analyzed, and their relations to the outcome of treatment and relapse rates were assessed.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of acute lymphoblastic leukemia * in case of informed consent and assent exclusion criteria: * paients or parents refusal

Keywords: acute lymphoblastic leukemia single nucleotide polymorphism
circulating micrornas in patients with stemi complicated with cardiogenic shock

Conditions: STEMI; Cardiogenic Shock; Acute Coronary Syndrome; microRNA

Summary: the aim of the study is knowing the prognostic value of circulating mirnas in patients admitted to our hospital with stemi complicated with cardiogenic shock.


Eligibility criteria:
inclusion criteria: * age \> 18 years * st elevation by ecg diagnostic of stemi * evidency of coronary occlusion in coronariography * signed informed consent exclusion criteria: * patients admitted from other hospitals * impossibility of getting blood samples in first 6h * declined consent
open and laparoscopic hernia repair. a comparative study

Conditions: Inguinal Hernia

Summary: a retrospective comparative study in a pediatric surgery center to compare the outcomes of 2 approaches of hernia repair in the pediatric population.

the investigators reviewed the records of all children who underwent open or laparoscopic hernia repair between january 2017 and july 2019 at the pediatric surgery center at the jordan university hospital. data collection included the age, gender, laterality of the hernia, the surgical approach, duration of surgery, time to discharge and time to full recovery.

Eligibility criteria:
inclusion criteria: * all children within the age limit specified were included in the study exclusion criteria: * none
bladder thermal distention for patients with interstitial cystitis / painful bladder syndrome

Conditions: Interstitial Cystitis; Painful Bladder Syndrome

Summary: patients with interstitial cystitis / pbs will be treated with bladder thermal distention (btd).

in this study we will evaluate the efficacy of bladder thermal distention (btd) in patients with ic/pbs. patients with previous failed conventional treatment (intravesical dmso) will be recruited.

Eligibility criteria:
inclusion criteria: -all patients with interstitial cystitis / painful bladder syndrome (ic/pbs) who had previous intravesical treatment with dmso exclusion criteria: * active infection * urethral stricture

Keywords: interstitial cystitis painful bladder syndrome bladder hydrodistention hyperthermia
cognition following computer assisted total knee arthroplasty

Conditions: Cognition; Embolism, Fat

Summary: a significant number of patients experience postoperative cognitive changes following total joint arthroplasty. among other causes, the mental status change may be the result of fat and bone marrow debris embolization. we hypothesized that the use of computer assisted total knee arthroplasty, which does not utilize intramedullary alignment rods, would produce less fat and bone marrow debris embolization and, hence, fewer mental status changes.

inclusion criteria * primary, cemented knee arthroplasty * unilateral or bilateral tka exclusion criteria * patient is unable to speak english * unable to read and write * patient with history of psychiatric disorders (depression, schizophrenia, anxiety, bipolar dis.) * patients with history of iv drug abuse * previous history of dementia * patients on mental status changing medications

Eligibility criteria:
inclusion criteria: * primary, cemented knee arthroplasty * unilateral or bilateral tka exclusion criteria: * patient is unable to speak english * unable to read and write * patient with history of psychiatric disorders (depression, schizophrenia, anxiety, bipolar dis.) * patients with history of iv drug abuse * previous history of dementia * patients on mental status changing medications

Keywords: mental cognition change fat embolism bone marrow debris emboli computer assisted total knee arthroplasty conventional instrumented total knee arthroplasty
adding cytokines to in vitro human culture media to improve embryogenesis and implantation

Conditions: Infertility

Summary: assessment of the embryological benefit of in vitro adding of cytokines (lif 5ng/ml, hb-egf 5ng/ml and gm-csf 2n/ml) to the culture media and closely monitor its effect on embryogenesis and implantation outcomes.

the ivf culture media design and upgrade underwent many ideas during the last 3 decades, we suppose that adding the cytokines (lif 5ng/ml, hb-egf 5ng/ml and gm-csf 2ng/ml) as a growth factor that have multi-ways to might improve embryo development in vitro so we decide to design a trial to compare the embryogenesis by sibling oocytes of the same patient between two arm of the same culture media and the same culture condition. one arm with cytokines and the other is traditional one and closely monitor the outcome within the 2 arms and record the results.

Eligibility criteria:
inclusion criteria: * all patients exclusion criteria: * over 40 years

Keywords: in vitro culture of human embryos
a study to assess the safety and efficacy of tafamidis in chinese participants with transthyretin amyloid cardiomyopathy (attr-cm)

Conditions: Transthyretin Amyloid Cardiomyopathy

Summary: this is a national, multi-center, single-arm study, open-label to patients with symptomatic transthyretin amyloid cardiomyopathy (attr-cm) who are tafamidis naïve. this study is to obtain safety, descriptive efficacy, pharmacokinetics (pk) and pharmacodynamics (pd) data for tafamidis orally once daily. subject eligibility for participation in the study will receive tafamidis once daily or 12 months following the assessment as the screening and baseline, month 1, 3, 6, 9 and 12 visits (or early study discontinuation).


Eligibility criteria:
inclusion criteria: 1. subject has documented attr-cm. 2. for the reproductive criteria for male and female participants, please refer to relevant protocol sections. exclusion criteria: 1. other acute or chronic medical or psychiatric condition including recent or active suicidal ideation or behavior or laboratory abnormality, in the judgment of the investigator, would make the participant inappropriate for entry into this study. 2. participants who have prior liver and/or heart transplant. 3. participants with primary (light chain) or secondary amyloidosis. 4. previous administration with an investigational drug within 30 days or 5 half lives preceding the first dose of study intervention used in this study (whichever is longer).

Keywords: tafamidis
long-term prognosis and valve durability of tavr

Conditions: Aortic Valve Stenosis and Insufficiency

Summary: this registry aims to evaluate the long-term prognosis and valve durability of transcatheter aortic valve replacement (tavr) in a real-world setting. baseline characteristics, procedural data, and clinical outcomes will be collected in a prospective and observational manner.


Eligibility criteria:
inclusion criteria: patients diagnosed with severe aortic valve regurgitation undergo evaluation by the heart team and are eligible for tavr therapy. 2. patients who understand the purpose of this study, agree to participate in the trial and sign the informed consent form * 1. patients with aortic stenosis or aortic valve insufficiency who were evaluated by the heart team and underwent tavr therapy * 2. patients who understand the purpose of the study, agree to participate in the trial and sign the informed consent form exclusion criteria: * 1. patients who cannot provide informed consent * 2. patients who are participating in other clinical trials

Keywords: aortic valve disease tavr prognosis valve durability
the benefits of the use of a support bra in women undergoing coronary artery by-pass graft surgery

Conditions: Quality of Life; Wound Complications; Pain

Summary: that study have the primary purpose identify if exist difference to the healing and quality of life between women that use of a surgical support bra, common support bra and without support bra after coronary artery bypass graft surgery. to do this, will be assessed pain, healing of the wound (dehiscence, infection) and quality of life life through specific instruments.

the patients will be randomized and share into three groups: women after coronary artery bypass surgery use surgical support bra, women after coronary artery bypass surgery use common support bra and those who will not use any support bra. they will be can tracked and invited to participate in the study few days before the surgery or during the post operatory (2 - 6 days after surgery). the assessement and the intervention must be start in the inpatient unit from the 2nd to 6th post operatory until their discharge. initially, it will be apply a questionnaire of quality of life (sf36) to assess the quality of life before the surgical procedure. in this moment, will be measured for breast size and also wil be identify the risk factors through a brief historical. during the stay in the hospital, the patients will be assessed on a daily basis with respect to the following: pain (verbal numerical scale) and wound appearance. the questionnaire of quality of life(sf36) will be applied again for more three times, about one month, two months and six months after the discharge together with the assessement to the pain and wound healing.

Eligibility criteria:
inclusion criteria: * women who undergoing coronary artery bypass graft surgery * women who signed the term consent and informed exclusion criteria: * women who have had any breast surgery * women who undergoing radiotherapy to the thorax. * women with cognitive impairments.

Keywords: pain quality of life wound healing
expression levels of nicotinamide metabolism-related protein (nmap) in newly diagnosed renal cancer and non-renal cancer populations

Conditions: Carcinoma, Renal Cell

Summary: this study aims to observe the difference between nmap (nicotinamide metabolism associated protein) serum levels in primary diagnosed renal cancer patients and non-renal cancer patient controls, plot the roc curve and establish appropriate cut-off values.


Eligibility criteria:
inclusion criteria: 1. the tumor group patients were found to have renal or hepatic mass, plan to receive surgical treatment (except for radiofrequency ablation, cryoablation, etc., which were not available for pathological examination). the control group patients were ruled out of tumor based on radiological tests and commonly used tumor biomarkers 2. age ≥ 18 years old and able to provide written informed consent; 3. have not received any systemic or topical treatment for kidney/liver tumors. 4. cardiopulmonary, liver and kidney functions are able to tolerate surgery and can comply with research requirements. exclusion criteria: 1. the investigators believe that the subject may be unsuitable for inclusion due to severe concurrent diseases, infections, and etc. 2. the subjects is known or suspected of other malignancies. 3. there has been another history of malignancy in the past 5 years. 4. major surgery (surgery requiring general anesthesia) was performed within 4 weeks prior to screening visits.

Keywords: renal cancer tumor biomarker
intravenous remifentanil for labor analgesia

Conditions: Labor Pain

Summary: labor analgesia is an essential health caring procedure for women. however, epidural analgesia cannot be performed on all subjects for different contraindications, such as lower platelet counter, back infection at the puncture site, and fear of epidural injection etc. therefore, intravenous analgesia is an alternative for such conditions. given the influence of intravenous administration of drugs on fetus, the drug selection is very important. remifentanil, a super-short efficacious opioid, can last for 3-4 minutes after injection, which is similar in both maternal and fetal environment. thus the fetus-associated side effects would be less than other drugs. the investigators hypothesized that remifentanil would be a superior intravenous drug used with patient-controlled technique for labor analgesia.


Eligibility criteria:
inclusion criteria: 1. nulliparous women 2. \> 18 years and \< 45 years 3. spontaneous labor 4. analgesia request 5. epidural puncture contraindications 6. tendency of bleeding exclusion criteria: 1. allergy to opioids, a history of the use of centrally-acting drugs of any sort, chronic pain and psychiatric diseases records 2. participants younger than 18 years or older than 45 years 3. those who were not willing to or could not finish the whole study at any time 4. using or used in the past 14 days of the monoamine oxidase inhibitors 5. alcohol addictive or narcotic dependent patients were excluded for their influence on the analgesic efficacy of the epidural analgesics 6. subjects with a nonvertex presentation or scheduled induction of labor 7. cervical dilation was 5.0cm or greater before performing epidural puncture and catheterization 8. diagnosed diabetes mellitus and pregnancy-induced hypertension 9. twin gestation and breech presentation

Keywords: remifentanil patient-controlled analgesia intravenous analgesia
a safety and efficacy study of tralokinumab in adults with asthma

Conditions: Asthma

Summary: the purpose of this study is to determine whether the addition of tralokinumab to standard asthma medication is effective in the treatment of adults with asthma.

interleukin-13 (il-13) is a key mediator in the pathogenesis of established asthmatic disease. tralokinumab is a human monoclonal antibody that blocks il-13, which may result in improved control of asthma. this study will determine whether the addition of tralokinumab to standard asthma medications results in a reduced rate of asthma exacerbations in subjects with severe asthma.

Eligibility criteria:
inclusion criteria: * age 18-75 years * body mass index (bmi) between 16-40 kilogram per square meter (kg/m\^2) at visit 1 * uncontrolled severe asthma * a chest x-ray with no abnormality * females of childbearing potential who are sexually active with a non-sterilized male partner must use highly effective contraception from day 1 * non-sterilized males or sterilized males who are less than or equal to (=\<) 1 year post-vasectomy who are sexually active with a female partner of childbearing potential must use a highly effective method of contraception exclusion criteria: * employee of the clinical study site or any other individuals directly involved with the conduct of the study, or immediate family members of such individuals * pregnant or breastfeeding women * any other respiratory disease * previously taken tralokinumab (the study drug) * current smoker or a history of smoking which would be more than 1 pack per day for 10 years * known immune deficiency * history of cancer * hepatitis b, c or human immuno-deficiency virus (hiv) * any disease which may cause complications whilst taking the study drug.

Keywords: asthma tralokinumab cat-354
evaluation of cognitive functions in 20 patients with type 1 myotonic dystrophy with virtual reality approach

Conditions: Myotonic Dystrophy 1

Summary: type 1 myotonic dystrophy (md1) is a genetic and hereditary disease that primarily affects muscle tissue, resulting in myotonia (difficulty relaxing after contraction) and atrophy (progressive muscle weakening with decreased muscle volume). it also affects eyes, heart, endocrine system, gastrointestinal system and central nervous system. specific cognitive abilities are impaired in patients with md1 such as attention, visio-spatial or visio-building abilities as well as executive dysfunctions. currently, the cognitive assessment of md1 patients is based on classical neuropsychological tests, which are time-consuming and require a md1 expert neuropsychologist. moreover, it is usually very difficult for md1 patients to accept performing these tests, and when they agree to perform them, they usually give up before the end. this finding is more frequent in md1 patients with high level of cognitive impairment. in order to overcome these difficulties in assessing cognitive functions of md1 patients, the investigators decided to use innovative tools such as virtual reality, which allow individuals to experience a sensory-motor and cognitive experience in a digitally world through a helmet, glasses and joysticks. the start-up my cyber royaume from lille, in collaboration with the reference center of neuromuscular diseases from nice coordinated by pr sacconi, have developed a software "good diag nmd" which uses virtual reality to assess cognitive disorders, more specifically executive functions in patients with type 1 myotonic dystrophy.


Eligibility criteria:
inclusion criteria: * male or female age ≥ 18 * suffering with type 1 myotonic dystrophy confirmed by molecular biology * suffering with dysexecutive impairments, with a pathologic bref score ≤ 15 * affiliated to social security * able to understand the inform consent form exclusion criteria: * suffering with visual or auditive impairments preventing them doing tests * suffering with other pathologies preventing them doing tests * suffering with motor impairments preventing them holding joysticks or carrying helmet * protection by law under guardianship, or who cannot participate in a clinical study under article l. 1121-16 of the french code of public health * patient under treatment that may affect cognitive functions (ie : modafinil) * participation in the last 3 months in a clinical research study in which he / she has been exposed to a pharmaceutical product or a medical device * pregnant or breastfeeding female patient
outcome of classic bladder exstrophy repair, assiut university experience

Conditions: Bladder Exstrophy

Summary: 1. to review surgical and medical outcomes of the previous repaired bladder exstrophy cases. 2. to present recent developments in surgical techniques and care of these patients.

* exstrophy-epispadias complex (eec) is a spectrum of genitourinary malformations resulting from abnormal cloacal development . * cbe, the most common form with an incidence of 2.68 in 100,000 live births is characterized by an evaginated bladder plate, epispadias and an anterior defect of the pelvis, pelvic floor and abdominal wall * the single most important predictor of long-term bladder growth and continence is successful primary bladder closure . * the staged reconstruction of bladder exstrophy was proposed by jeff and led to significant improvements in continence and renal function with excellent cosmetic results. * the initial staged management consisted of newborn bladder and posterior urethral closure followed by bladder neck reconstruction at 2 to 3 years of age and later epispadias repair. * the understanding that appropriately timed epispadias repair may lead to enhancement in bladder capacity led to performance of epispadias repair at 2 to 3 years of age followed by later bladder neck reconstruction. the current modification of the staged repair consists of secure bladder and posterior urethral closure in infancy followed by epispadias repair at 6 to 12 months of age and bladder neck reconstruction when the patient is able to cooperate in a good voiding program. * complete repair surgery is performed in a single procedure that closes the bladder and the abdomen and repairs the urethra and outer sex organs * a failed classic bladder exstrophy (cbe) closure is defined by wound dehiscence, bladder prolapse, bladder outlet obstruction, or formation of a vesicocutaneous fistula.

Eligibility criteria:
inclusion criteria: - all patient with cbe who underwent repair at assiut university hospital. exclusion criteria: * cloacal exstrophy isolated epispadias previous failed repair out assiut university hospital
bathe method on preoperative anxiety, patient satisfaction and individual anesthesia concerns

Conditions: Anesthesia; Reaction; Anxiety Preoperative; Patient Satisfaction

Summary: in this study the goal is to determine the causes of concern among the patients who will undergo surgical operations and receive general anesthesia, to gauge their preoperative anxiety levels and to study the effects of the bathe method on preoperative anxiety and patient satisfaction.

in this study the goal is to determine the causes of concern among the patients who will undergo surgical operations and receive general anesthesia, to gauge their preoperative anxiety levels and to study the effects of the bathe method on preoperative anxiety and patient satisfaction. 500 patients who were planned to undergo elective surgery and under general anesthesia as anesthesia method were included in the study. demographic data of patients, their three biggest fears of anesthesia and apais scores were recorded. the patients were divided into two groups, they underwent bathe anamnesis or standard anamnesis methods according to their groups, then their apais and patient satisfaction scores were recorded.

Eligibility criteria:
inclusion criteria: a) asa i-ii patients exclusion criteria: a) asa iii-iv b) illiterate patients c) patients with known psychiatric disorders d) patients with chronic sedative e) antipsychotic drug use f) patients with a history of going to psychiatry in the last year g) patients with any cancer diagnosis were not included in the study.

Keywords: preoperative anxiety anesthesia anxiety bathe method apais patient satisfaction
comparing efficacy of 14-day therapy doxycycline with bismuth subsalicylate versus levofloxacin with tinadizole on treatment helicobacter pylori

Conditions: Helicobacter Pylori Infection

Summary: comparison efficacy of 10-days therapy with doxycycline with bismuth subsalicylate versus levofloxacine with tinadizole on eradication of helicobacter pylori in syrian population.


Eligibility criteria:
inclusion criteria: * patients are aged greater than 18 years old who have h. pylori infection diagnosed by any of following three methods: * positive rapid urease test (clotest). * histologic evidence of h. pylori by modified giemsa staining. * positive 13c-urea breath test. without prior eradication therapy and are willing to receive therapy. exclusion criteria: * children and teenagers aged less than 18 years. * previous eradication treatment for h. pylori. * patients who took any drug, which could influence the study results such as proton pump inhibitor, h2 blocker, mucosal protective agent and antibiotics. * history of gastrectomy. * gastric malignancy, including adenocarcinoma and lymphoma, * previous allergic reaction to antibiotics (amoxicillin, tinadizole, * doxycycline,bismuth subsalicylate,) and prompt pump inhibitors (es- omeprazole). * contraindication to treatment drugs. * pregnant or lactating women. * severe concurrent disease. * liver cirrhosis.

Keywords: doxycyclien bismuth subsalicylate helicobacter pylori levofloxacine tinadizole