Kornimate/medical-research-clean huggingface dataset:
sniff - 3-week aptar cps device

Conditions: Mild Cognitive Impairment; Cognitive Impairment; Alzheimer Disease, Early Onset

Summary: the sniff 3-week aptar device study will involve using a device to administer insulin or placebo through each participant's nose or intra-nasally. insulin is a hormone that is produced in the body. it works by lowering levels of glucose (sugar) in the blood. this study is measuring how much insulin the device delivers. in addition, this study will look at the effects of insulin or placebo administered intra-nasally using an intranasal delivery device on memory, blood, and cerebrospinal fluid (csf).

the proposed study will examine whether an intranasal delivery device can be used by adults with preclinical alzheimer's disease (cognitively normal but with abnormal brain levels of the hallmark peptide aβ) to reliably deliver insulin or placebo four times daily over a 4 week period. we will also examine effects of treatment on cognition, csf biomarkers, and cerebral perfusion. if successful, information gained from the study will inform the design of future phase iii trials of intranasal insulin.

Eligibility criteria:
inclusion criteria: 1. age 55 to 85 (inclusive) 2. fluent in english 3. cognitively normal or diagnosis of amnestic mild cognitive impairment (amci) or mild alzheimer's disease (ad) 4. amyloid positive by positron emission tomography (pet) or cerebrospinal fluid (csf) criteria 5. stable medical condition for 3 months prior to screening visit 6. stable medications for 4 weeks prior to the screening and study visits (exceptions may be made on a case by case basis by the study physician) 7. clinical laboratory values must be within normal limits or, if abnormal, must be judged to be clinically insignificant by the study physician exclusion criteria: 1. a diagnosis of dementia other than alzheimer's disease (ad) 2. history of a clinically significant stroke 3. current evidence or history in past two years of epilepsy, head injury with loss of consciousness, any major psychiatric disorder including psychosis, major depression, bipolar disorder 4. diabetes (type i or type ii) insulin-dependent and non-insulin-dependent diabetes mellitus 5. current or past regular use of insulin or any other anti-diabetic medication within 2 months of screening visit 6. history of seizure within past five years 7. pregnancy or possible pregnancy 8. use of anticoagulants 9. residence in a skilled nursing facility at screening 10. use of an investigational agent within two months of screening visit 11. regular use of alcohol, narcotics, anticonvulsants, anti-parkinsonian medications, or any other exclusionary medications (exceptions may be made on a case by case basis by the study physician)

Keywords: intranasal delivery of insulin cognitive testing nasal insulin
relationship between pelvic floor dysfunctions and sexual dysfunction in female patients with systemic sclerosis

Conditions: Systemic Sclerosis (SSc); Sexual Dysfunctions; Pelvic Floor Disorder

Summary: relationship between pelvic floor dysfunctions and sexual dysfunction in female patients with systemic sclerosis

female patients with systemic sclerosis have a high incidence of pelvic floor dysfunction and sexual dysfunction.the association of sexual dysfunction in systemic sclerosis with many disease-related factors has been confirmed. there are numerous studies in the literature investigating the prevalence and risk factors of sexual dysfunction in women with ssc, the number of studies examining the prevalence and effects of pelvic floor dysfunction in ssc is limited. moreover, no studies were identified in the literature that specifically investigate the relationship between pelvic floor dysfunction and sexual dysfunction.the aim of this study is to evaluate pelvic floor dysfunction and sexual dysfunction in women with ssc, examine the relationship between these dysfunctions, and compare the findings with data from a healthy control group.

Eligibility criteria:
inclusion criteria: * female gender * being between 18-64 years old * having a diagnosis of systemic sclerosis (ssc) * being sexually active, and not having entered menopause the control group will consist of healthy women aged 18-64 years who are sexually active, have not entered menopause, have no history of urological or gynecological surgeries other than cesarean section, and have no rheumatologic or severe chronic diseases. exclusion criteria: * the presence of current or past rheumatologic diseases other than ssc * the presence of current urogynecological diseases * a history of urological or gynecological surgeries other than cesarean section.

Keywords: systemic sclerosis female sexual dysfunction pelvic floor disorders
acute effects of supramaximal high-intensity interval training in people with copd

Conditions: COPD; Healthy Older Adults

Summary: high-intensity exercise is essential for optimal development of cardiorespiratory fitness and health. this is, however, challenging for most people with chronic obstructive pulmonary disease (copd) due to ventilatory limitations, leading to exercise at lower intensities accompanied by suboptimal stress on the cardiovascular and muscular system. the aims of this cross-over trial is: 1. to compare the acute effects of short-duration supramaximal high-intensity interval training (hiit) vs. traditional moderate-intensity continuous training (mict) in people with copd and matched healthy controls (hc). 2. to investigate the feasibility of supramaximal hiit in people with copd and matched hc. 3. to compare the cardiorespiratory demand, exercise intensity and symptoms during a modified borg cycle strength test (bcst) and a cardiopulmonary exercise test (cpet) in people with copd and hc.

in this study, eligible participants attended the facility four times within 14 days with at least 48 hours of rest between visits. exercise tests (visit 1, week 1): after pulmonary functions tests, a cpet on a stationary bicycle was performed according to international guidelines. after 1.5 hours of recovery, a bcst was performed to assess anaerobic exercise capacity and determine exercise intensities for supramaximal hiit. exercise sessions (visit 2 - week 1; visit 3 - week 2; visit 4 - week 2): the order of the two first exercise sessions (hiit at 60% of mpo6 or mict) on a stationary bicycle were randomized. the exercise session at hiit at 80% of mpo6 was always the third exercise session. during all exercise sessions, blood collection was performed at baseline after a 15-minute seated rest. during hiit, blood was collected immediately after, and 30 minutes after the 10-minute hiit period. for mict, blood was collected after 10 minutes (isotime in relation to hiit), immediately after, and 30 minutes of cycling at 60% map.

Eligibility criteria:
copd inclusion criteria: * copd with non-reversible airflow obstruction diagnosis (post-bronchodilator forced expiratory volume during the first second/forced vital capacity (fev1/fvc) \< 0.7) * age: \> 40 years exclusion criteria: * recent exacerbation of copd (\< 6 weeks) * neuromuscular, orthopaedic and/or any other condition that can compromise participation in testing * recent lung cancer (\< 5 years) * unstable cardiac disease and/or cardiac stimulator hc inclusion criteria: - age: \> 40 years exclusion criteria: * neuromuscular, orthopaedic and/or any other condition that can compromise participation in testing * any respiratory disease * recent lung cancer (\< 5 years) * unstable cardiac disease and/or cardiac stimulator * too low or high physical activity level that prohibits matching

Keywords: acute exercise high-intensity interval training
topiramate trial for pathological gamblers

Conditions: Pathological Gambling

Summary: objectives: pathological gambling (pg) is a prevalent disorder with no approved pharmacological treatment. previous reports suggest that topiramate could be useful in reducing impulsivity in pg, and craving in other addictions. the goal of this study was to investigate the effectiveness of topiramate combined with brief cognitive restructuring in treating pg. methods: 38 pg patients were randomized to either topiramate (n=18) or placebo (n=20) in a 12-week double-blind trial; all patients received brief cognitive restructuring. the main outcome measures were craving, gambling behaviour, gambling cognitive distortions, impulsivity, depression and social adjustment.


Eligibility criteria:
inclusion criteria: * current diagnostic and statistical manual fourth edition text revised (dsm-iv-tr) diagnosis of pathological gambling * a betting frequency of at least once a week in the last 30 days * women within fertility age had to be already practicing an acceptable contraception method and to be negative at a pregnancy test. exclusion criteria: * illiteracy * breastfeeding for women * previous history of alcohol abuse/dependence with current elevation of liver enzymes, or a present diagnosis of alcohol abuse/dependence * past or current drug abuse/dependence, except for nicotine dependence * history of current or past dsm-iv-tr diagnosis of bipolar disorder, schizophrenia, psychosis or any neuropsychiatric condition causing cognitive impairment * a history of suicide attempt or acute suicide risk * severe depression indicated by a score equal to or higher than 30 at the beck depression inventory * current participation in psychotherapy for pathological gambling, including gamblers anonymous in the past 3 months * current use of mood stabilizers, antidepressants, antipsychotics, except occasional use of benzodiazepines * cardiovascular disease including a history of heart attack, stroke, arrhythmia, cardiac failure in the past 5 years * chronic or acute renal and liver failure * a personal or family history of nephrolithiasis * immunodeficiency * any blood dyscrasia.
a phase 2 study of asc-j9 cream in acne vulgaris

Conditions: Acne Vulgaris

Summary: the purpose of this study is to evaluate if topical asc-j9 cream is effective in treating acne.

subjects with acne were randomized to one of four treatment groups for twice daily topical dosing to the face for 12 weeks. assessments of acne status were performed at baseline, weeks 2, 4, 8 and 12 and then 4 weeks after the last dose of study drug.

Eligibility criteria:
inclusion criteria: * at least 12 years of age. * facial acne, with: 20 -100 inflammatory facial lesions 20 -100 noninflammatory facial lesions no more than 2 nodules/cysts on the face exclusion criteria: * women who are pregnant or breastfeeding * skin diseases other than acne vulgaris * use of oral retinoids within 6 months of baseline visit * unwilling to discontinue all other treatments for facial acne * unwilling to avoid excessive swimming/sun exposure and use of cosmetics

Keywords: acne
effects of a digital diary on the psychological well-being of former icu patients.

Conditions: Depression, Anxiety; Post Traumatic Stress Disorder; Quality of Life

Summary: previous research on the impact of a diary on mental symptoms of pics, pics-f, and quality of life in former icu patients and their relatives has focused specifically on a paper diary. while there has been research on the experiences of former icu patients, relatives, and icu nurses regarding the use of a digital diary, it is not known whether this diary has an impact on the psychological well-being and quality of life of former icu patients and their relatives. a successful implementation of \[the digital diary\] enables this research. the aim of this study is, therefore, to provide an initial impression of the health-related effects of a digital diary on former icu patients and their relatives.

objective: exploring health-related effects of a digital icu diary in former icu patients and their relatives. research question 1: what is the effect of a digital icu diary on the psychological well-being and quality of life in former icu patients and their relatives? research question 2: what is the effect of a digital icu diary on the perceived quality of care and satisfaction with the icu admission among relatives of former icu patients?

Eligibility criteria:
inclusion criteria for former icu patients and their relatives: * capacity to make decisions autonomously * proficiency in the dutch language * 18 years of age or older * icu length of stay \>48 hours * no use of an icu diary before (pre-measurement) * used the digital post-ic diary for more than 1 day (post-measurement) exclusion criteria for former icu patients and their relatives: * insufficient proficiency in the dutch language to express themselves on the subject. * patients with a pre-admission diagnosis of psychosis or dementia. * use of a paper icu diary.

Keywords: quality of care digital icu diary icu survivors relatives
phase iii study of lenalidomide and dexamethasone with or without elotuzumab to treat newly diagnosed, previously untreated multiple myeloma

Conditions: Multiple Myeloma

Summary: the purpose of the study is to determine whether the addition of elotuzumab to lenalidomide/low-dose dexamethasone will increase the progression free survival (pfs)


Eligibility criteria:
for more information regarding bms clinical trial participation, please visit www.bmsstudyconnect.com. inclusion criteria: * subjects who are newly diagnosed with symptomatic multiple myeloma (mm) and who: * have not received any prior systemic anti-myeloma therapy and * have measurable disease and * are not candidates for high-dose therapy plus stem-cell transplantation (sct) because of age (≥ 65 years) or coexisting conditions. refusal to undergo high dose therapy with sct is not sufficient for entry onto ca204006 for a subject \< 65 years old. there must be a comorbidity that prevents sct for a subject \< 65 years old exclusion criteria: * subjects with non-secretory or oligo-secretory or free light-chain only myeloma * smoldering mm, defined as asymptomatic mm with absence of lytic bone lesions * monoclonal gammopathy of undetermined significance (mgus) * active plasma cell leukemia * known human immunodeficiency virus (hiv) infection or active hepatitis a, b, or c

Keywords: newly diagnosed previously untreated
vocal warm-up and respiratory muscle training

Conditions: Voice Disorders

Summary: the purpose of this study is to verify the effects of two speech-pathology interventions: vocal warm-up and respiratory training in teachers who work in a public school of the city of salvador-bahia, with or without complaints of vocal disorders. it is a preventive study and the hypothesis is that both approaches can produce positive voice changes, but the vocal warm-up will produce the most significant changes.

randomized clinical trial where participants were allocated into groups: vocal warm-up (to perform exercises of resistance and flexibility for 13 minutes before teaching, during six weeks) and respiratory muscle training (to perform exercises to strengthen the respiratory muscles through the use of incentive respiratory equipment. five repetitions of exhales with an interval of thirty seconds between each one were performed. it was requested rest for two minutes, repeating the procedure four times with the total of five series. these exercises were performed for 13 minutes before teaching, during six weeks). outcomes analyzed: demographics and teaching activity characteristics; symptoms, habits and factors associated with voice disorders; self-reported voice handicap (voice handicap index-vhi-10); vocal severity rating (vocal severity scale); and acoustic parameters through the computerized acoustic voice analysis program voxmetria (cts informatics).

Eligibility criteria:
inclusion criteria: * age between 20-60. * no occurence of speech therapy simultaneously to the intervention exclusion criteria: * professional voice use in another activity; * frequent use of alcohol and tobacco; * influenza and/or upper respiratory tract infections (eg, rhinitis, sinusitis, pharyngitis) during the period of participation in the research.

Keywords: voice training education voice faculty
association of cd49d and cd44 in cll patients and their role in prognosis

Conditions: Cellular Diagnosis, Chronic Lymphocytic Leukemia

Summary: the interactions of chronic lymphocytic leukemia cells with the microenvironment in secondary lymphoid tissues and the bone marrow are known to promote cll cell survival and proliferation

chronic lymphocytic leukemia (cll) is the most common type of chronic leukemia, accounting for approximately 40% of all leukemia's and mainly affecting older individuals. as it has a highly variable clinical course, identification of molecular and biological prognostic markers has provided new insights into the risk stratiﬁcation of patients with cll . the interactions of chronic lymphocytic leukemia cells with the microenvironment in secondary lymphoid tissues and the bone marrow are known to promote cll cell survival and proliferation . cd49d (one of biomarkers) is one of independent prognostic risk parameter in cll with important roles in shaping these interactions. cd49d also is one of independent prognostic risk parameters in cll that predict adverse outcome and linked to processes involved in interaction with the vascular endothelium and/or migration into the extravascular compartments . the cell-surface glycoprotein cd44 is involved in cell motility, cellular trafficking, and stem cell differentiation . it contributes to the phenotypic hallmarks of many cancers, such as invasiveness, self-renewal, and sustained survival. cd44 transmits both growth and apoptotic signals, a functional duality that is also observed in hematologic malignancies. cd44 expression in cll is mediated by the tumor microenvironment. as a coreceptor, cd44 promotes leukemogenesis by regulating stimuli of mcl1 expression. moreover, cd44 can be addressed therapeutically in cll by specific antibodies.

Eligibility criteria:
inclusion criteria: * all patients are newly diagnosed as cll exclusion criteria: * : patients with associated malignancies
comparison of weight loss and nutritional deficiency after one anastomosis gastric bypass at 150, 170, and 200 cm from the duodenojejunal junction

Conditions: Obesity; Nutritional Deficiency; Type 2 Diabetes Mellitus (T2DM); Bariatric Surgery (Gastric Bypass)

Summary: this study is a randomized clinical trial comparing the effects of one anastomosis gastric bypass performed at three different distances from the duodenojejunal junction-150 centimeters, 170 centimeters, and 200 centimeters-on weight loss outcomes and nutritional status in patients with obesity. one anastomosis gastric bypass is a type of bariatric surgery that combines aspects of a gastric sleeve and a traditional gastric bypass, aiming to achieve effective weight loss and improvement in health conditions associated with obesity. the study will include 60 adult patients between 18 and 60 years old with a body mass index of 35 kilograms per square meter or greater, or a body mass index of 30 kilograms per square meter or greater with obesity-related health conditions, who have not achieved adequate results through diet, exercise, or medication. participants will be randomly assigned to one of three groups, each undergoing one anastomosis gastric bypass with a different limb length from the duodenojejunal junction: 150 centimeters, 170 centimeters, or 200 centimeters. the primary outcomes measured will include the percentage of total weight loss, the percentage of excess weight loss, and postoperative nutritional status, particularly in terms of levels of albumin, calcium, iron, and ferritin. secondary outcomes will assess the remission of health conditions related to obesity, including high blood pressure and type 2 diabetes mellitus, as well as patient quality of life following surgery. by examining the impact of one anastomosis gastric bypass at varying limb lengths on weight loss and nutritional deficiencies, this study aims to identify an optimal surgical approach that balances effective weight management and minimizes the risk of postoperative malnutrition. the findings will inform surgical decision-making and postoperative management strategies for individuals undergoing one anastomosis gastric bypass.


Eligibility criteria:
inclusion criteria: * adults aged 18 to 60 years. * body mass index (bmi) of 35 kg/m² or higher, or bmi of 30 kg/m² or higher with significant obesity-related comorbidities. * failed adequate conservative management (diet, exercise, and/or medication) for at least 6 months. * demonstrated psychological stability and motivation for surgery. * acceptance of the surgical risks associated with bariatric procedures. exclusion criteria: * prior abdominal exploratory surgery. * previous bariatric surgery. * pre-existing significant nutritional deficiencies. * pregnancy or current lactation. * severe, long-standing cardiac or pulmonary disease or other serious systemic illnesses. * active substance or alcohol abuse. * active gastric ulcer disease. * psychological instability.

Keywords: one anastomosis gastric bypass duodenojejunal junction weight loss surgery bariatric surgery nutritional deficiency obesity treatment postoperative nutrition
study of zio-101 in multiple myeloma

Conditions: Multiple Myeloma

Summary: the study of safety of a new organic arsenic compound in the treatment of advanced multiple myeloma


Eligibility criteria:
subjects with multiple myeloma who have received at least two prior therapies and currently require therapy.

Keywords: multiple myeloma arsenic cancer study failed treatment
saccharomyces cerevisiae for irritable bowel syndrome

Conditions: Irritable Bowel Syndrome

Summary: this study is designed to see the response of saccharomyces cerevisiae for symptomatic improvement of patients with ibs


Eligibility criteria:
inclusion criteria: * male and female patients between 18 and 75 years of age, * patients having confirmed ibs according to rome iv criteria (newly and previously non-responder to treatment), * pain/ discomfort score strictly above 1 and strictly below 6 as determined on a pain/ discomfort scale using arbitrary grading from 0 to 7 in 7 days preceding the inclusion visit, * not hypersensitive to any of the ingredients of the drug. exclusion criteria: * patients with an organic intestinal disease (crohn's disease, ulcerative colitis, etc.), * pregnant females * treatments likely to influence ibs (anti-depressants, opioids, and narcotic analgesics) * patients with chronic alcoholism, vegetarian or vegan regimens * eating disorders such as anorexia or bulimia * documented food allergies.
investigational drug study in patients with elevated cholesterol and coronary heart disease (0653-801)

Conditions: Hypercholesterolemia; Coronary Disease

Summary: this study will evaluate patients who have coronary heart disease to determine if an investigational drug will further lower cholesterol when taken in combination with an approved cholesterol lowering medication.

the duration of treatment is 10 weeks.

Eligibility criteria:
inclusion criteria: * patients with elevated cholesterol and coronary heart disease exclusion criteria: * patients who do not meet specific cholesterol levels as required by the study

Keywords: elevated cholesterol