Kornimate/medical-research-clean huggingface dataset:
effects of muscle energy techniques versus core stability exercises in pelvic girdle pain

Conditions: Pelvic Girdle Pain

Summary: pgp is referred to as a specific form of lbp which occurs isolatedly as well as in combination with lumbar back pain. pgp localized to the anterior or posterior pelvis, most commonly located between the posterior iliac crest and gluteal folds especially around the si joint. pelvic girdle pain radiated to the posterior thigh

pelvic girdle pain (pgp) is known to be a musculoskeletal disorders which affects the pelvic bone. pgp is referred to as a specific form of lbp which occurs isolatedly as well as in combination with lumbar back pain. pgp localized to the anterior or posterior pelvis, most commonly located between the posterior iliac crest and gluteal folds especially around the si joint. pelvic girdle pain radiated to the posterior thigh. moreover, it can also cause pain in the symphysis (1). compared to lower back pain, pgp is substantially more painful and linked with functional limitations as standing, walking, sitting and changing positions are less tolerable in such patients (2). pgp is musculoskeletal in nature and is not caused by gynecological or urological conditions (3). despite the fact that the cause of pgp is unknown, it is considered that it occurs due to many reasons such as trauma, arthritis, anatomical fault or it can be associated with pregnancy (4

Eligibility criteria:
inclusion criteria: * females of 25 to 40 years were included in this study.(20) * female patients who gave birth at least 6 months before.(20) * females who gave birth through vaginal delivery.(20) * females with at least three positive pain provocative tests such as posterior pelvic pain provocation test (p4), active straight leg raise test (aslr), thigh thrust, patrick's faber test, gaenslen's test and distraction test.(20) * history of pain around the pelvic girdle, lower back or between the posterior iliac crest and the gluteal fold, difficulty in walking and/or pain when putting weight on one leg exclusion criteria: * females who suffered from grade 3 or 4 vaginal tears during their pregnancy (20) * females who underwent episiotomy during delivery (20) * females who delivered through caesarean section (20) * postpartum females with a history of trauma to the pelvic region (20) * postpartum females with a history of pelvic surgery * postpartum females with a history of other orthopedic disorders
assessment of a proposed microbiological alert and its impact on a sepsis campaign

Conditions: Sepsis

Summary: the aim of the present study was to evaluate the ability of health-care professionals in addressing sepsis, and the impact of a telephone call upon receival of blood cultures in the clinical microbiology department, from a clinical microbiologist, in the early management of sepsis.

sepsis is one of the major challenges of modern medicine. it is an important health problem with a high incidence, morbidity and mortality that affects population worldwide. without an early recognition and a prompt management, patients can develop more severe stages of the disease and even death. an appropriate and aggressive management can significantly improve outcomes. thus, it is necessary to develop early warning systems of sepsis in the hospital. in recent years, several campaigns and guidelines have been developed to help health care professionals in the management of sepsis. however, these have mainly focused on management protocols for severe sepsis and septic shock in intensive care units or emergency departments. to the best of the investigators knowledge, none of these have examined in depth either the impact of a sepsis alert system in general wards, nor the impact of a telephone call from a specialist in clinical microbiology, upon blood culture request, in the early recognition of sepsis. the aim of the present study was to evaluate the ability of health-care professionals in addressing sepsis, and the impact of a telephone call upon receival of blood cultures in the clinical microbiology department, from a clinical microbiologist, in the early management of sepsis. for this, the investigators performed a prospective study based on telephone calls followed by a phone interview to physicians and nurses in charge of patients whose blood cultures had just been received at the clinical microbiology department in a tertiary hospital.

Eligibility criteria:
in-patients with blood cultures drawn and sent to the microbiology laboratory, regardless of patient allocation (eg., emergency department, intensive care units, general wards) opportunity sampling: patients whose clinical history number ended in odd numbers were assigned to group a (intervention) and patients whose clinical history number ended in even numbers were assigned to group b (no intervention, control group). inclusion criteria: * patients who had blood cultures drawn and sent to the microbiology laboratory, during the morning shift (from 9 am to 3 pm, monday to friday) * patients \>/=18 years old exclusion criteria: * patients \<18 years old * patients with a recent bacteremic episode with no subsequent negative blood cultures * in-patients with blood cultures drawn to whom the telephone call had already been performed.

Keywords: sepsis diagnosis sepsis drug therapy sepsis outcome
subcutaneous apomorphine in the treatment of progressive supranuclear palsy and cortico basal degeneration (apoparka)

Conditions: Progressive Supranuclear Palsy; Corticobasal Degeneration

Summary: treatment of tauopathies such as progressive supranuclear palsy (psp) and cortico basal degeneration (cbd) remains a major challenge. these rare severe neurodegenerative extrapyramidal movement disorders share phenotypic overlap and are usually painful. parkinson disease (pd) is a common extrapyramidal movement disorder and continuous subcutaneous apomorphine infusion (csai) is commonly used in advanced pd patients to alleviate motor and non-motor fluctuations. effects of subcutaneous apomorphine were investigated especially on pain and, on quality of life in 7 patients with psd or cbd.this is an observational "real life" surveillance-based study.the verbal rating scale for pain (vrs) was used to assess changes in pain level and the clinical global impression-improvement scale (cgi-i) was used to assess changes in patient's illness before and during six months of treatment. detailed report of the symptoms and side effects has been recorded by home nurses throughout the study period.


Eligibility criteria:
inclusion criteria: * psp or cbd patients for whom a treatment with subcutaneaous apomorphine is indicated exclusion criteria: * pregnant or breastfeeding women * patient under a legal protection procedure * patient denying to participated to the study * lack of affiliation to a social security system

Keywords: pain quality of life
glivec in prostate cancer patients with rising psa following radical prostectomy

Conditions: Prostatic Neoplasm; Genital Neoplasms, Male; Neoplasms, Abdominal; Urogenital Neoplasms; Genital Diseases, Male; Prostatic Diseases; Antineoplastic Agents; Imatinib

Summary: to investigate the ability of 600 mg of glivec®, given once daily by mouth to patients with rising psa following radical prostatectomy, to produce a sustained biochemical response during the first 6 months of treatment.


Eligibility criteria:
inclusion criteria: * who are 18 years of age or older. * who have undergone radical prostatectomy within 2 years prior to psa progression . * exhibiting two consecutive rises in psa levels relative to a previous reference value, separated by 14 days. the first measurement must occur 14 days after the reference value und must be at least 20% above the reference value. the reference value must be at least 0.4 ng/ml. the second confirmatory measurement taken 14 days after the first measurement must be greater than the first measurement. * with a karnofsky performance score (kps) greater than or equal to 90 (appendix 5). * with the following hematologic lab values: anc greater than or equal to 1500/mm3, hgb greater than or equal to 10g/dl, plt greater than or equal to 100x109/l. * with the following biochemistry lab values: total bilirubin \< 1.5 uln, sgot, sgpt less than or equal to 2.5 uln, serum creatinine less than or equal to 1.5 uln. * willing to employ an effective barrier method of contraception during the study duration and for 3 months following discontinuation of study drug (for patients of reproductive potential). * with a life expectancy of \> 6 months. * who have provided written informed consent pursuant to local regulatory requirements prior to initiation of any study procedure. with a gleason score \> 6 in the prostatectomy specimen exclusion criteria: * with a history of another malignancy within 5 years prior to study entry, except curatively treated non-melanotic skin cancer, unless written approval is obtained by the sponsor. * with prior hormonal therapy * who require therapy with warfarin or analgesics of the morphine class or higher (see section 3.4.4). * with a known diagnosis of hiv, hepatitis b, or hepatitis c infection. * who have had a major surgery within 2 weeks prior to study entry. * with severe, unstable, or uncontrolled medical disease which would confound diagnoses or evaluations required by the protocol, including severe cardiac insufficiency (nyha iii or iv, see appendix 2), uncontrolled diabetes, chronic hepatic or renal disease, and active uncontrolled infection. * with a history of noncompliance to medical regimens or inability or unwillingness to return for all scheduled visits. other protocol-defined inclusion/exclusion criteria may apply

Keywords: prostate cancer, radical prostatectomy, psa rise
the effect of chewing gum and use of stress balls on perception of labor pain, fear of birth, and duration of delivery

Conditions: Labor Pain; Birth Satisfaction; Duration of Birth

Summary: this study was conducted as a randomized controlled experimental study. this study was planned to determine the effects of chewing gum and using a stress ball on the perception of labor pain, duration of labor and birth satisfaction. the population of the study consisted of primiparous mothers who applied to the hospital. this study was planned to determine the effects of chewing gum and using a stress ball on the perception of labor pain, duration of labor and birth satisfaction. the study was carried out in two stages. in the first stage, the data were collected in the delivery room, and in the second stage, the postpartum satisfaction levels of the mothers were measured in the postpartum service. the sample number of the investigators' study was determined as 96. visual analog scale, birth satisfaction scale and birth follow-up form were used for the data of our study.


Eligibility criteria:
inclusion criteria: * being primiparous to be in due time * to have spontaneous vaginal delivery * ability to communicate verbally be between the ages of 18-35 * not having a risky pregnancy * having a single fetus in the vertex position * having started contractions and continuing regularly * being in the latent phase of action (0-4 cm dilatation) * not having used any analgesia or using any pain medication to reduce pain during labor exclusion criteria: * mothers who have a cesarean section decision * risky pregnant * multiple pregnancies * multiparous pregnant women

Keywords: chewing gum, stress ball labor pain satisfaction
feasibility of internet group cbt-i for gyn oncology patients

Conditions: Insomnia

Summary: the goal of this study is to evaluate the feasibility and acceptability of delivering cognitive behavioral therapy for insomnia (cbt-i) to gynecologic cancer patients in an internet-based small-group setting. secondary objectives: 1. to compare insomnia symptoms before and after intervention. 2. to evaluate any changes in quality of life symptoms while undergoing the intervention. 3. to evaluate the duration of symptoms improvement after the intervention is complete.

this is a pilot feasibility study looking at delivering cbt-i to gynecologic cancer patients. this study will be completed via a novel internet based small group platform. twelve eligible participants will meet weekly for 6 weeks while undergoing the cbt-i program.

Eligibility criteria:
inclusion criteria: 1. english-speaking women greater than 18 years old who present to uc davis comprehensive cancer center for treatment or surveillance of gynecologic cancer 2. must have access to internet 3. be able to connect via secure web-based platform 4. be able to complete online questionnaires 5. moderate or severe insomnia 6. have access to a mobile device or computer exclusion criteria: 1. participants without ability to connect with both audio and visual through secure web-based platform 2. participant is currently taking sleep medication prescribed by their provider for sleep disturbance or insomnia - patients taking over the counter medications or supplements are eligible 3. participants with remote history of insomnia, but not currently having symptoms of insomnia 4. have other reasons for poor sleep
a study of the safety and tolerability of inhaled snsp113 in healthy subjects and subjects with stable cystic fibrosis

Conditions: Lung Diseases; Pulmonary Disease; Cystic Fibrosis; Cystic Fibrosis Lung; Cystic Fibrosis Pulmonary Exacerbation; Cystic Fibrosis With Exacerbation; Respiratory Tract Disease; Pulmonary Inflammation; Multi-antibiotic Resistance; Antibiotic Resistant Infection; Lung Infection; Lung Infection Pseudomonal; Lung; Infection, Atypical Mycobacterium; Burkholderia Infections; Burkholderia Cepacia Infection; Lung Inflammation

Summary: although cystic fibrosis is a complex genetic disease affecting many organs, lung disease is the primary cause of mortality. the objective of this study is to determine the safety and tolerability of snsp113 in healthy subjects and subjects with stable cystic fibrosis.


Eligibility criteria:
inclusion criteria: part a * healthy male adults ≥18 and ≤50 years of age at screening. * baseline fev1 80-120% of predicted at screening. * oxygen saturation of ≥ 96% on room air as determined by pulse oximetry at screening. * screening laboratory tests within normal limits. part b * female and male subjects who are ≥18 years of age and a confirmed diagnosis of cf. * fev1 \>50% of predicted. * oxygen saturation of ≥ 94% on room air as determined by pulse oximetry at screening. * stable cf pulmonary disease as judged by the investigator. exclusion criteria: part a * any history of any form of lung disease or any systemic disease that may affect the lung or pulmonary function. * former regular smoker or has smoked tobacco or cannabis products within the last 30 days. * any history of any form of liver disease, renal disease, cardiac disease, hematologic disease, neurologic disease, atopy or any chronic condition. * participation in one or more healthy subject studies within the prior 3 months. part b * participation in a clinical trial involving receipt of an investigational product within the 30 days prior to screening. * female subjects who are pregnant (a negative serum pregnancy test must be demonstrated at screening), have a positive pregnancy test, are lactating or who plan to become pregnant within 90 days after dosing. * subjects requiring supplemental oxygen. * hemoptysis of \>5 ml within 12 weeks of screening. * listed for organ transplantation.

Keywords: cystic fibrosis pulmonary exacerbation pulmonary inflammation respiratory tract disease pulmonary disease biofilms
cytosponge and dietary therapy in eoe

Conditions: Eosinophilic Esophagitis

Summary: this study is being done to see if the investigators can use only the cytosponge ( a 10 minute, in office procedure that does not require sedation) to replace the 6-10 endoscopies routinely perform during dietary restriction and food reintroduction in eoe?

dietary therapy has been shown to be successful in the treatment of adult and pediatric patients with eosinophilic esophagitis dietary studies were initially reported in children, but the results appear to be similar in adult patients. elemental diets are successful in 70-95% of patients but are poorly tolerated. a six food elimination diet has been effective in about 70% of adult patients with eoe . in these adult studies skin prick testing was not helpful in predicting which foods would lead to a flare of disease when reintroduced into the diet. therefore, the current standard of care requires multiple egds with esophageal biopsy during the dietary restriction and reintroduction phases of this study. since the investigators are making lifelong dietary decisions during this process of food reintroduction, it is imperative the investigators be accurate. unfortunately, these multiple egds have significant cost and are invasive procedures with some risk. moreover, there is significant indirect costs with travel and time off work for the patients and drivers. previous studies have found the esophageal sponge to be an accurate technique of accessing esophageal eosinophilia in eoe . the sponge is swallowed as a 12 mm capsule on a string. the capsule rapidly dissolves upon entering the stomach and the sponge then expands and can be pulled out the mouth five minutes after ingestion. in previous studies, the procedure was very well tolerated and all patients preferred the sponge to endoscopy. therefore the sponge is a well tolerated, inexpensive, very low risk procedure that would be an ideal option to replace egd esophageal sampling in the evaluation of dietary treatment of eoe.

Eligibility criteria:
inclusion criteria: * diagnosed with eosinophilic esophagitis \> than 15 eos phf and failed to respond to the ppi therapy * going through the six food elimination diet or have just completed elimination the six foods: fish, nuts, eggs, soy, wheat, and milk exclusion criteria: * clinical evidence of infectious process potentially contributing to dysphagia ( candidiasis, cmv, herpes) * other cause of dysphagia identified at endoscopy (e.g. reflux esophagitis, stricture, web, ring, achalasia, esophageal neoplasm) * esophageal minimal diameter \< 13 mm on structured barium esophagram

Keywords: eoe
electromyography triggered functional electrical stimulation on stroke patients

Conditions: Stroke

Summary: my study aims to apply treatment program for postural instability in stroke patients.

my study include two groups: first group receive physical therapy exercise program followed by balance exercise program. the second group receive the same physical therapy exercise program followed by balance exercise program conducted with electromyography triggered functional electrical stimulation

Eligibility criteria:
inclusion criteria: * stroke patients * normal body mass index * mild spasticity exclusion criteria: * musculoskeletal deformities * cognitive abnormalities * cardiovascular diseases
perineal preparation for pregnant ladies.

Conditions: Delivery; Trauma; Pelvic Floor; Perineal Rupture, Obstetric; Pelvic Floor Muscle Weakness

Summary: pregnant participants will be recruited at the obstetrics outpatient clinic during their visits 4 weeks before the due date. they are randomized into two groups. the first group will be educated to do digital perineal massage. they will be also educated to do pelvic floor muscle exercises and will receive the usual education program for strengthening the pelvic floor. the second group will receive the usual education program for strengthening the pelvic floor. occurrence of perineal laceration will be reported at time of delivery.

pregnant participants will be recruited at the obstetrics outpatient clinic during their visits 4 weeks before the due date. they are randomized into two groups. the first group will be educated to do digital perineal massage. they will be also educated to do pelvic floor muscle exercises and will receive the usual educational pelvic floor dysfunction prevention program for strengthening the pelvic floor. the second group will receive the usual education program for strengthening the pelvic floor. occurrence of perineal laceration will be reported at time of delivery.

Eligibility criteria:
inclusion criteria: * pregnant women ≥ 35 years old * primigravida or multi gravida exclusion criteria: * history of chronic constipation * history of chronic cough * current or past urinary or anal incontinence * history of genital prolapse before pregnancy * history of neuromuscular disorders or connective tissue disorders * history of medical disorders * history of preterm or precipitate labour * history of premature preterm rupture of membranes. * genital infections

Keywords: perineal massage health education perineal tear episiotomy pelvic floor muscle exercise
correlation between neck pain and postural abnormalities among female office workers at university of dammam

Conditions: NECK PAIN

Summary: this study is a cross sectional study conducted to find out the correlation between neck pain and postural abnormalities among female office workers at university of dammam by objective assessments methods. eligible participants will sign the consent form followed by filling up demographic data, visual analog scale \& neck disability index. after that, forward head posture and thoracic kyphosis posture will take place by valid and reliable methods.

the study population and sampling were calculated by raosoft sample size calculator using an estimated average of population size 200 and allowing a 5% tolerable error, based on a 95% confidence interval (ci). about 140 female office workers were targeted from the medical colleges of university of dammam (uod); medicine, applied medical science, nursing, dentistry, clinical pharmacology and health track of preparatory year were recruited into the study (n=140). the study was approved by the institutional review board (irb) at the university of dammam (irb-pgs-2015-03-194). eligible individuals for this study were informed of the risks and benefits and were asked to read and sign a written consent form. participants' confidentiality was maintained by using a code (number) instead of the participant's name on the data collection form. all data collection forms were saved in a file and secured in a locker \& the electronic file saved with password. only the researcher and the supervisor had an access to them.

Eligibility criteria:
inclusion criteria: * subjects with/without non-specific neck pain complaint. * age from 28 up to 40 years old. * at least 25 working hours a week ( at least 2 hours on computer - at least 3 other office working). * more than 5 years of experience as an office worker. exclusion criteria: * subjects who had prolonged absence from work anticipated within the past 12 months. * complain of: cervical radiculopathy, migraine, vestibular dysfunction. * had spinal fracture or surgery. * pregnancy. * history of cervical trauma. * comorbid medical conditions as cancer, type 1 diabetes, heart disease.

Keywords: neck pain, office workers