Kornimate/medical-research-clean huggingface dataset:
a study of sdi-118 in participants in remission from depression

Conditions: Depression in Remission

Summary: this is a multi-center, double-blind, randomized, placebo-controlled study to determine the safety, tolerability, and pharmacodynamics of sdi-118 in a once daily (qd) dosing regimen on male and female study participants reporting with cogntive decline and who in remission from depression.


Eligibility criteria:
inclusion criteria: * male and female participants between 25 and 55 years of age (inclusive) at screening. * are remitted from depression. * have received prescribed treatment with an antidepressant or a recognised psychotherapy for depression (e.g. cognitive behaviour therapy) for a previous mde * report present subjective cognitive impairment (such as difficulty concentrating, slow thinking, and difficulty in learning new things or remembering things). * have not been treated with antidepressants or received other psychotherapy for depression for at least six weeks prior to screening visit 1. * otherwise healthy with no clinically significant abnormalities as determined by medical history, physical examination, blood chemistry assessments, haematologic assessments, and urinalysis, measurement of vital signs, and electrocardiogram (ecg). * negative serology test for human immunodeficiency virus (hiv) antibodies, hepatitis b surface antigen (hbsag) or hepatitis c virus (hcv) antibodies at screening. * have a body mass index (bmi) of 18 to 36 inclusive. * agree not to use herbal medications (including herbal tea, st. john's wort), within 14 days prior to study agent administration through to the final follow-up visit. * participants must be able and willing to give written, informed consent, indicating that they understand the purpose of and procedures required for the study and are willing to participate in the study. * the participant, in the opinion of the investigator, is willing and able to adhere to the study visit schedule and other requirements, prohibitions and restrictions of the study. exclusion criteria: * they are left-handed. * have immediate recall of greater than 22 words from the international shopping list test (islt) and have delayed recall of greater than 8 words from the islt 15 mins after the presentation of the word list. * positive urine drug screen or alcohol breath test at screening or assessment visits. * history or presence of significant neurological or psychiatric conditions except those related to mdd. * any suicidal ideation of type 4 or 5 in the columbia suicide severity rating scale (c-ssrs) in the past 3 months prior to screening or at screening or baseline visit. * has a known clinically relevant structural brain abnormality as determined by e.g. previous mri, or, persistent mri imaging artefact which is judged to produce extensive imaging distortions. * has a disease or takes medication that could, in the investigator's and/or sponsor's opinion, interfere with the assessments of safety, tolerability, or efficacy, or interfere with the conduct or interpretation of the study.

Keywords: depression major depressive disorder depression in remission
effects and mechanisms of melatonin on blood pressure, insulin resistance, and platelets

Conditions: Prehypertension; Healthy

Summary: the investigators will be studying the effect of melatonin on blood pressure, insulin resistance, and platelets, along with possible reasons for how melatonin cases these effects.

the investigators will be studying the effect of melatonin on blood pressure and insulin resistance, and possible reasons for how melatonin works on blood pressure and ir. along with blood testing to measure adipokines, insulin resistance (ir), and platelet function (how well your blood clots), 24-hour ambulatory blood pressure monitoring (abpm) will be used to measure blood pressure, since abpm is the gold standard (best method) for accurate assessment of blood pressure status and associated cardiovascular risk. vascular (blood vessel) function, ir, adipokine levels and sleep quality will also be measured. all study endpoints will be measured at baseline and following 6 weeks of daily melatonin 9 mg dosing.

Eligibility criteria:
inclusion criteria: * normotensive (sbp \<120) or prehypertensive (sbp = 120-139 mm hg) * age: young/middle-aged (ages 18-45) and (2) 10 elderly subjects ages 65 and older exclusion criteria: * patients with a diagnosis of * clinical hypertension and/or diabetes mellitus * pregnancy * coronary or cerebrovascular disease * collagen vascular disease, * organ failure (heart, kidney, liver). * patients taking anti-inflammatory medications: nsaids, corticosteroids, thiazolidinediones, and statins, * patients who have taken melatonin previously in the past year.
swept-source optical coherence tomography for noninvasive retinal vascular imaging

Conditions: Retinal Vascular Disease

Summary: this is a clinical pilot study to assess the feasibility of using a swept-source optical coherence tomography (ssoct) system to perform noninvasive imaging of the retinal vasculature in patients with existing microvascular disease.

this project is being conducted under an abbreviated ide. subjects with existing retinal microvascular disease will be recruited from among the patients of the duke eye center and/or its associated satellite clinics. following informed consent, subjects undergo imaging, per established standard operating procedure, at the duke university medical center/duke center or at one of the duke eye center satellite clinics. pharmacologic dilation of eyes will not be necessary for completion of imaging and will not be used for the purposes of this study. the resulting images will not be used in the clinical care of any of the subjects recruited for this project. subjects will be identified from patients presenting for ophthalmologic consultation at the duke eye center and/or its satellite clinic locations.

Eligibility criteria:
inclusion criteria: 1. capable and willing to provide consent 2. history of clinically-diagnosed retinal microvascular diseases, including but not limited to diabetic retinopathy, retinal vein occlusion, idiopathic macular telangiectasias, hypertensive retinopathy, and age-related macular degeneration 3. at least 18 years of age exclusion criteria: 1. unable or unwilling to give consent 2. under 18 years of age

Keywords: retinal vascular disease swept-source ocular coherence tomography ssoct
prospective cohort of opiate dependent patients on buprenorphine/naloxone for maintenance

Conditions: Opiate Dependence

Summary: the purpose of this study was to expand access to buprenorphine using a mobile health care system among marginalized populations with or at high risk for hiv and observe longitudinal effects of treatment.


Eligibility criteria:
inclusion criteria: * hiv + * at high risk for hiv (iv drug use, commercial sex worker, partner of hiv+) * mental health (unmanaged or diagnosed mental illness) exclusion criteria: * benzodiazepine use * opiate use due to pain management issues only (present or past) * non-idu

Keywords: opiate dependence buprenorphine
treatment of refractory bk infections with related donor bk specific cytotoxic t-cells (ctls)

Conditions: Viral Infection; Primary Immune Deficiency Disorder

Summary: bk cytotoxic t cells (ctls) manufactured with the miltenyi clinimacs prodigy cytokine capture system will be safe and effective in decreasing specific viral load in children, adolescents and young adults (caya) with refractory bk infection post allogeneic hematopoietic stem cell transplantation (allohsct) or with primary immunodeficiencies (pid).


Eligibility criteria:
inclusion criteria: .1.1 patients with refractory bk infection post allogeneic hsct, post solid organ transplantation or with primary immunodeficiencies with either * increasing urine and/or plasma bk rt-pcr dna (by 1 log) after 7 days or persistent quantitative qrt-pcr dna copies after 14 days despite two weeks of appropriate anti-viral therapy and/or * medical intolerance to anti-viral therapies including: * 2 renal toxicity with cidofovir or other \> grade 2 toxicities secondary to cidofovir and/or * known resistance to cidofovir 1.2. consent: written informed consent given (by patient or legal representative) prior to any study-related procedures. 1.3 performance status \> 30% (lansky \ 16 yrs) 1.4 age: 0.1 to 79.99 years 1.5 females of childbearing potential with a negative urine pregnancy test exclusion: 1. patient with acute gvhd \> grade 2 or extensive chronic gvhd at the time of bk ctl infusion 2. patient receiving steroids (\>0.5 mg/kg prednisone equivalent) at the time of bk ctl infusion 3. patient treated with donor lymphocyte infusion (dli) within 4 weeks prior to bk ctl infusion 4. thymoglobulin (atg) or alemtuzumab within 30 days 5. patient with poor performance status determined by karnofsky (patients \>16 years) or lansky (patients ≤16 years) score ≤30% 6. concomitant enrollment in another experimental clinical trial investigating the treatment of refractory bk infection. 7. any medical condition which could compromise participation in the study according to the investigator's assessment 8. known hiv infection 9. female patient of childbearing age who is pregnant or breast-feeding or not willing to use an effective method of birth control during study treatment. 10. known hypersensitivity to iron dextran 11. patients unwilling or unable to comply with the protocol or unable to give informed consent. 12. known human anti-mouse antibodies
intravenous remifentanil plus morphine or morphine alone for postthoracotomy pain

Conditions: Pain

Summary: background; post-thoracotomy pain remains a major problem. this double-blind, randomized study tested the effects of coadministration of patient controlled remifentanil+morphine combination on postthoracotomy pain, analgesic consumption and side effects compared with morphine pca alone

methods; sixty patients were allocated randomly to receive an intravenous patient-controlled analgesia with morphine alone (m), or morphine plus remifentanil (mr), in a double-blind manner. postoperatively patients were allowed to use bolus doses of morphine (0.2 mg kg-1) or morphine (0.2 mg kg-1) plus remifentanil (0.2 µg kg-1) mixture every 10 min without a background infusion. pain, discomfort, sedation scores, total and bolus patient-controlled morphine consumption, rescue analgesic requirement and side-effects were recorded for up to 24 h after the start of patient-controlled analgesia.

Eligibility criteria:
inclusion criteria: * 60 asa physical status i-iii patients, between the ages of 18 and 59 years, scheduled for elective thoracotomy surgery with general anaesthesia were included in this study exclusion criteria: * severe hepatorenal disease history, sensitivity or contraindication to morphine and remifentanil, chronic pain (defined as regular use of opioid analgesics for \> 3 months), drug or alcohol abuse and contraindication to administration of pca

Keywords: postthoracotomy pain, patient controlled analgesia, remifentanil and morphine.
prevalence of non-traumatic musculoskeletal disorders in the french paragliding pilots population

Conditions: Prevalence; Musculoskeletal Disorders

Summary: the main objective is to determine the prevalence of non-traumatic pathologies in the paragliding population using the nordic type questionnaire. the paragliding pilots population frequently evoque pathologies, discomfort, or pain in the course of their practice. said pain and discomfort, though unerelated any form of accident, seem to have an impact on the pilots' flying and their participation in daily life. however, no epidemiological data are available in the literature. investigators hypothesize the existence of non-traumatic disorders and it seems interesting to quantify the extent of the phenomenon. the results of this study might encourage the proposition of preventive measures in order to minimize a potential risk factor for paragliding accidents, and participation restrictions.

in this cross-sectional descriptive epidemiological survey, investigators wish to quantify epidemiological parameters such as the prevalence of pathologies and their consequences in the activities of daily life. for this purpose, an email containing the link to answer the online questionnaire will be sent to all the licensees. the link of the questionnaire will be sent directly to all clubs in each league. the main objective is to calculate the prevalence with descriptive statistics. the primary outcome is the prevalence of non-traumatic pathology in paragliding pilots that had registered to the french paragliding federation (ffvl) in 2022. the prevalence will be infered from the irsst standardised nordic questionnaire with the following formula : prevalence = (fs4+fs6=yes and fs2=no ) divided by the total number of respondents. fs4 item "yes" = pain in the last 12 months fs6 item "yes" = activity limitations) fs2 item "no" = non-traumatic disorders this corresponds to having felt pain in the body region indicated, at least once during the last 12 months, as well as a restriction of participation following this pain, but without having suffered trauma in the area. for the secondary outcomes will aim at exploring several hypotheses related to personal and environmental factors that could be correlated to the incidence of the nontraumatic disorders. they will be calculated with bivariate descriptive statistics using the pvalue.io software.

Eligibility criteria:
inclusion criteria: * over 18 years old * registered with the ffvl for the year 2022 and/or 2023 * paragliding in the year 2022 and/or 2023 exclusion criteria: * adults not able to express their consent

Keywords: paragliding musculoskeletal diseases non-traumatic pathology standardised nordic questionnaire overuse injury
evaluation of nano-crystalline hydroxyapatite silica gel in management of periodontal intrabony defects

Conditions: Chronic Periodontitis

Summary: a clinical and radiographic evaluation of nano-crystalline hydroxyapatite silica gel in comparison with open flap debridement for management of periodontal intrabony defects.

thirty patients suffering from advanced chronic periodontitis were included in this randomized controlled clinical trial. each subject contributed matched two- or three-walled intrabony defects. patients were equally assigned into the experimental group; nano-crystalline hydroxyapatite silica gel or the negative control group;open flap debridement. clinical and radiographic parameters were recorded at baseline and at 3 and 6 months postoperatively.

Eligibility criteria:
inclusion criteria: * severe chronic periodontitis patients. * having at least one site with pocket depth ≥ 6 mm and clinical attachment level ≥ 5 mm, with radiographic evidence of bone loss as detected in periapical radiographs. exclusion criteria: * pregnant women * subjects had \<22 permanent teeth * having any given systemic disease * taking any type of medication and/or antibiotic therapy during the 3 months before the study * received periodontal treatment within the past 12 months current or former smokers
efficacy of transcutaneous electrical nerve stimulation (tens) and kinesio taping in patients with lateral epicondylitis

Conditions: Pain in Arm, Unspecified; Tenosynovitis Elbow; Lateral Epicondylitis (Tennis Elbow) Bilateral

Summary: lateral epicondylitis is the most common condition affecting the elbow and characterized by pain over the lateral epicondyle. the aim of this study was to determine and compare the efficacy of tens and kinesio taping in lateral epicondylitis.

in this prospective-randomized, assessor blinded controlled trial, seventy-eight patients (63 women, 15 men, mean age 47,5 ±7,94 years) with lateral epicondylitis were enrolled. patients were allocated into 4 treatment groups: group 1 received tens and kinesio taping, group 2 received tens+sham kinesio taping, group 3 received sham tens+ kinesio taping and group 4 received sham tens+sham kinesio taping. tens was applied for 10 sessions and kinesio taping for 4 times in 10 days. all patients were given a progressive exercise program and were informed about the disease. all patients were told to take paracetamol 500 mg if their pain is severe and to note the number of the paracetamol taken. outcome measures were pain-free grip strength, pressure pain threshold and pain severity at rest, night and forced wrist extension test. patient-rated tennis elbow evaluation (prtee) was used to determine functional status. patients were assessed for outcome measures at screening, after treatment (day 10) and 12th week after the treatment.

Eligibility criteria:
inclusion criteria: * aged 19 to 72 * enough cognitive ability to fill clinical assessment forms * agreed to participate in the study exclusion criteria: * severe or progressive neurological deficits * severe psychiatric disease history, substance and/or alcohol dependence, * uncontrolled diabetes mellitus, malignancy, osteoporosis * a history of inflammatory or infectious disease * a skin allergy story * previously undergone physical therapy due to lateral epicondylitis

Keywords: kinesio taping lateral epicondylitis tennis elbow tens
conventional verses ultrasound guided arteria cannulation, with and without local anesthesia

Conditions: Heart Disease

Summary: the aim of the project is to compare two methods for arterial cannulation. the traditional method with ultrasound guided cannulation. the investigators goal is to improve this procedure to reduce pain and complications.

the practice of placing vascular catheters is used many times every day at almost every hospital. it is a safe procedure which generally does not imply problems. though the procedural optimum aren't reached. the procedure still fails some times and induce complications. when the catheter is placed using the traditional method the pulse is palpated by the operator's fingers. this is only to be done near the hand wrist. in this position the catheter steadiness is fragile but because the pulse can't be sensed more proximal the operator is forced to choose this position. this it though a problem that can be solved by non invasive visualization technology. ultrasound-guidance for central vascular access is already well-established. however, in recent years ultrasound-guidance for peripheral vascular access has gained popularity too. the evidence of multiple studies demonstrates increased success rate and reduced complication rate with ultrasound compared to blind landmark technique for vascular catheter placement. in recent years there have been both procedural technique and technology improvements in the field of ultrasound. this has led to the improvement of procedural catheterisation techniques that now can be done by novices with higher attempt success rate than traditional method. one technique that is gaining success is the short-axis-out-of-plane technique (sax-oop) with dynamic-needle-tip-tracking (dntt).using the ultrasound machine the needle can be placed in a more proximal direction on the forearm and the investigators believe that by the help of the exposed procedure on the monitor many complications can be reduced. hypothesis; firstly the investigators hypothesize that the pain induced by the conventional method inclusive preoperational lidocaine injection will be the same or more intense than using dntt without local anesthesia. secondly the investigators hypothesize that the use of dntt for the placement of the arterial catheter will decrease the time spend, amount of complications (hematoma), the number of pricks, the number of utilized catheters compared to the traditional palpation method. thirdly the investigators claim that the best anatomical place to put the catheter isn't always corresponding with the spot chosen by palpation, which increase the number of failures.

Eligibility criteria:
inclusion criteria: * age 20-90 years * fulfill the criteria of an operation * routine need of an arterial needle exclusion criteria: * lack of patient consent * ultrasound identified plaques in the radial artery or ultrasound verified positive allens test or traditional positive allens test

Keywords: arteria cannulation ultrasound pain complications
health education for women with breast cancer

Conditions: Breast Cancer Female

Summary: the sedentary lifestyle in women with breast cancer generates a problem for public health. an alternative that has been used to reduce sedentary behavior are interventions with the use of information technology, as well as projects with health education can cause lifestyle changes. however, little is known about the effect of these interventions on self-awareness and self-care in women with breast cancer. this aim of study is evaluate the effect of health education on sedentary behavior, lifestyle, physical activity level, nutrition, self-esteem, anxiety and depression, quality of life, pain, functional capacity, and strength in women with breast cancer. this is a study the 12 weeks, with patients being treated for breast cancer, distributed for two groups: group health education recommendations and control group.

this is a clinical trial with patients being treated for breast cancer, the sample will be randomly distributed into two groups: group health education recommendations (gres) and control group (cg), which will remain in usual care. the intervention will last for 12 weeks, where gres will receive health education recommendations in person and via social media. the endpoints of this study are sedentary behavior, lifestyle, physical activity level, nutrition, self-esteem, anxiety and depression, quality of life, pain, functional capacity, and strength. evaluations will be performed at baseline, after 6 weeks, and after 12 weeks. data will be analyzed by multivariate, comparing the effects of group, time, and interaction in spss software version 24.0, with α=5%.

Eligibility criteria:
inclusion criteria: * women 18 years or older; * diagnosed with breast cancer; * ongoing breast cancer treatment (chemotherapy, radiotherapy and/or hormone therapy); * have daily access to a smartphone. exclusion criteria: * women having another type of cancer; * perform physical training for three months before the intervention; * has medical contraindication to perform any type of physical activity; * have filled in yes on the par-q and medical contraindication; * without cognitive conditions to use a smartphone or answer questionnaires; * illiterate women.

Keywords: breast neoplasms sedentary behavior lifestyle health education