Kornimate/medical-research-clean huggingface dataset:
study of the effectiveness of osteopathic manipulative treatment in pregnant women

Conditions: Low Back Pain; Musculoskeletal Diseases; Pregnancy Complications

Summary: the purpose of this study is to determine whether osteopathic manipulative treatment (omt): * decreases pain and improves physical functioning in women during the third trimester of pregnancy * decreases complications during obstetrical delivery * improves quality of life in the post-partum period

women experience multiple changes in their anatomy and physiology during pregnancy that may cause pain and adversely affect quality of life. additionally, about ten percent of women will experience signs and symptoms of pre-eclampsia or pre-term labor during their first pregnancy. preliminary studies of osteopathic manipulative treatment (omt) have demonstrated a decrease in pain during pregnancy, although the mechanisms responsible for this effect are unclear. another theory is that osteopathic manipulative treatment (omt) may help normalize sympathetic outflow, thereby minimizing pregnancy complications. a recently published retrospective study also suggests that pregnant women receiving osteopathic manipulative treatment (omt) may be at lower risk for pre-term delivery and the presence of meconium during delivery.

Eligibility criteria:
inclusion criteria: * third trimester pregnancy exclusion criteria: * high risk pregnancy * previous use of chiropractic manipulation, osteopathic manipulative treatment (omt), physical therapy, or therapeutic ultrasound during the current pregnancy

Keywords: randomized controlled trial pregnant women
osa as a remote ischemic preconditioning in vascular surgery

Conditions: Obstructive Sleep Apnea; Vascular Aneurysm; Ischemia Reperfusion Injury

Summary: ischemia and reperfusion (i/r) injury during abdominal aortic aneurysm (aaa) repair is inevitable and may lead to postoperative multi-organ failure. remote ischemic preconditioning (short periods of ischemia in anticipation of longer period of ischemia) may act protectively against ischemia. studies of ischemic preconditioning in patients with aaa are conflicting. obstructive sleep apnea (osa) is a sleep disordered breathing syndrome which may have a protective effect against ischemia. the investigators hypothesize that i/r injury will be less pronounced in patients who have osa and that the extent of i/r injury will inversely correlate with osa severity. accordingly, the aim of this study is to compare postoperative complications and markers of i/r in patients undergoing elective aaa repair who do and do not have osa.

patients. consecutive patients scheduled for elective aortobifemoral bypass (aaa and leriche syndrome patients) will be recruited for this prospective, observational study. polygraphy (pg). pg measurements will be done two nights before surgery using the embletta system (embla - embletta mpr pg sleep data recording system). stop-bang, epworth questionnaire. both questionnaires will be done the same day as polygraphy cardiovascular complications will be assessed from the first 30 post-operative days pulmonary complications will be assessed from the first 30 post-operative days specific markers of i/r. t0 - before anesthesia induction t1 - 3 hrs after aorta de-clamping t2 - 12 hrs after aorta de-clamping t3 - 24 hrs after aorta de-clamping t4 - on the fifth post-operative day

Eligibility criteria:
inclusion criteria: * patients scheduled for elective aorto-bifemoral bypass (aaa and leriche syndrome patients) exclusion criteria: * emergent surgery * aorto-bifemoral bypass using deep vein graft * re-operations * known osa with cpap treatment

Keywords: remote preconditioning
effects of anesthesia on tumor immunity and insulin resistance during perioperative period

Conditions: Anesthesia; Cervical Cancer; Carbohydrate; Tumor Immunity

Summary: to evaluate the effects of preoperative oral carbohydrate on postoperative insulin resistance and tumor immunity in cervical cancer patients with neoadjuvant chemotherapy.

fifty-one patients undergoing neoadjuvant chemotherapy and radical hysterectomy with bilateral pelvic lymph node dissection were randomized to receive 300ml of an oral carbohydrate liquid supplement 2 hour before surgery(cho group) or to fast on standard hospital protocol (8 hour fasting for solid and 4 hour fasting for clear liquid)(fast group).according to inclusion and exclusion standards, twenty-six patients undergoing the same surgery and standard fasting were selected as control group. baseline and postoperative measurements of insulin sensitivity were assessed in term of fasting plasma glucose(fpg),fastingainsulin(fins),homa-insulinaresistance(homa-ir),homa-insulin secretion function index(homa-ix) , homa-beta cell function index(homa-β),serum c-peptide and glucagon.baseline and postoperative measurements of tumor immunity were evaluated using nk cell and t-cell dynamics.vas score was introduced to assess preoperative comfort.

Eligibility criteria:
inclusion criteria: 1. the patients aged from 18 to 60 years old were asa level i to ii, and the informed consent was signed by the patients, which was approved by the ethics committee of the hospital. 2. cervical squamous cell carcinoma was confirmed by cervical biopsy before pathologic surgery. ct showed no distant metastasis. all patients underwent total hysterectomy, bilateral adnexectomy and pelvic lymph node dissection. 3. fasting blood glucose was normal without diabetes, impaired glucose tolerance or other metabolic diseases. 4. no gastric emptying dysfunction. exclusion criteria: 1. dabetes 2. patients with obstruction of gastric emptying, such as pyloric obstruction, gastroesophageal reflux, nausea and vomiting, etc 3. obese (bmi \>32) or severely malnourished (bmi\<18.5) 4. distant metastasis, multiple primary cancers and recurrent tumors 5. patients with functional disorders of respiratory system, circulatory system, immune system, nervous system, urinary system and other organs 6. received blood transfusion and nutritional support within 2 weeks before surgery 7. the supplement contains the sugar solution, the blood transfusion, the application glucocorticoid, the sympathetic blood vessel activity medicine in the operation.
safety and immunogenicity of ev71 vaccine with or without aluminum adjuvant in infants

Conditions: Infection, Viral, Enterovirus

Summary: a randomized, double-blind, phase ii-02 clinical trial is to evaluate the safety and immunogenicity of an inactivated ev71 vaccine with or without aluminum adjuvant


Eligibility criteria:
inclusion criteria: 1. healthy males and females, aged from 6 to 11 months old health is determined by medical history, physical examination, laboratory examination and clinical judgment of the investigator 2. provided legal identification for the sake of recruitment. 3. subjects and/or parent(s)/legal guardian(s) are able to understand and sign informed consents. 4. birth weight more than 2500 grams exclusion criteria: 1. history of hand-foot-mouth disease 2. subject that has allergic history of vaccine, or allergic to any ingredient of vaccine 3. serious adverse reactions to vaccines such as anaphylaxis, hives, respiratory difficulty, angioedema, or abdominal pain 4. congenital malformations or developmental disorders, genetic defects, or severe malnutrition 5. epilepsy, seizures or convulsions history, or family history of mental illness 6. autoimmune disease or immunodeficiency, or parents, brothers and sisters have autoimmune diseases or immunodeficiency 7. history of asthma, angioedema, diabetes or malignancy 8. history of thyroidectomy or thyroid disease that required medication within the past 12 months 9. bleeding disorder diagnosed by a doctor (e.g. factor deficiency, coagulopathy, or platelet disorder requiring special precautions) or significant bruising or bleeding difficulties with im injections or blood draws 10. asplenia, functional asplenia or any condition resulting in the absence or removal the spleen 11. acute illness or acute exacerbation of chronic disease within the past 7 days 12. any history of immunosuppressive medications or cytotoxic medications or inhaled corticosteroids within the past six months (with the exception of corticosteroid nasal spray for allergic rhinitis or topical corticosteroids for an acute uncomplicated dermatitis) 13. history of any blood products within 3 months 14. administration of any live attenuated vaccine within 28 days 15. administration of subunit or inactivated vaccines ,e.g., pneumococcal vaccine, or allergy treatment within 14 days 16. axillary temperature \> 37.0 centigrade before vaccination 17. abnormal laboratory parameters before vaccination 18. any medical, psychiatric, social condition, occupational reason or other responsibility that, in the judgment of the investigator, is a contraindication to protocol participation or impairs a volunteer's ability to give informed consent
the efficiency of colon capsule endoscopy in colon cancer screening

Conditions: Colon Cancer

Summary: main objective is to improve colorectal cancer (crc) screening programme in the czech republic and decrease the disease incidence and mortality. the secondary aim is to verify the effectiveness of incorporation of the new minimally invasive device in the prevention programme.

multicentre, multidisciplinary (3 gastroenterology units; biostatistics department; cooperation with general practitioners), prospective study is focused on examination of individuals with average colorectal cancer (crc) risk (asymptomatic, age 50-75 years). in years 2017 - 2019, there will be 230 persons with positive semi-quantitative immunochemical fecal occult blood tests (fit; quikread, orion diagnostica oy, finland) with cut-off level 75 ng/ml involved. every person will be examined by second generation colon capsule endoscopy (cce2) and optical colonoscopy afterwards. main objective is to show that the negative predictive value (npv) of the cce2 applied in patients with positive fit results is sufficient to include this method in the national crc screening as filter test with aim to reduce the necessity of subsequent optical colonoscopy.

Eligibility criteria:
inclusion criteria: * age 50 - 75 years * asymptomatic (no enterorhagy, weight loss or anemia) * signed informed consent with the study and with colonoscopy exclusion criteria: * crc high-risk group patients * having first degree relatives diagnosed with colorectal cancer at age ˂ 60 years * fap, hnpcc and other hereditary crc syndromes probands * positive personal medical history of colorectal neoplasia (advanced adenomatous polyp, colorectal cancer) * recent diagnostic, follow-up or preventive colonoscopy in ≤ 3 years (fobt-positive colonoscopy, screening colonoscopy) * colonoscopy contraindication * severe acute inflammatory bowel disease * severe comorbidities; likely non-compliance of the patient * no informed consent signed (with the study and/or with colonoscopy)

Keywords: colorectal cancer screening colon capsule colonoscopy
using parkinson's disease to study the role of the substantia nigra pars reticulata

Conditions: Parkinson's Disease

Summary: parkinson's disease (pd) is a movement disorder causing either uncontrolled movement, slowness of movement, slowness of initiation of movement or rigidity of muscles. deep brain stimulation (dbs) is the fda-approved method for patients who no longer get effective treatment from the best available medication. the location in the brain where the electrode is placed during dbs surgery for pd is called the subthalamic nucleus or stn. this study aims to investigate another location in the brain, the substantia nigra pars reticulata or snr. the snr is also known to be involved in motor control of muscles and may be involved in the process by which the initiation of movement occurs.

parkinson's disease (pd) is a movement disorder causing either uncontrolled movement, slowness of movement, slowness of initiation of movement or rigidity of muscles. one method of easing pd symptoms is the fda-approved method of deep brain stimulation (dbs) for patients who no longer get effective treatment from the best available medication. the location in the brain where the electrode is placed during dbs surgery for pd is called the subthalamic nucleus or stn. during placement of the dbs electrode, the patient is awake and is asked to do motor tasks to determine the correct placement in the stn and proper functioning of the dbs electrode. this study aims to investigate another location in the brain, the substantia nigra pars reticulata or snr, during the normal placement of the dbs electrode. this location is also known to be involved in motor control of muscles and may be involved in the process by which the initiation of movement occurs. the path through the brain to the stn used for dbs surgery goes into the snr but currently, no testing of the snr is performed. we will conduct a simple and well documented visual motor test to document the patient's stimulus perception and motor intention both at rest and during neural stimulation of the snr.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of parkinson's disease * must be able to undergo awake surgery dbs * must have unaided vision to view visual motor task exclusion criteria: * corrective eyeglasses or contact lenses
esp block vs. traditional pain management for eras

Conditions: Postoperative Pain

Summary: patients undergoing thoracotomy, thoracoscopy or other surgical procedures involving the integrity of the chest wall are always in a special point of interest of both surgical and anesthesiological specialities. most of the patients will describe the pain after thoracic surgery as severe. it might lead to a number of serious complications: respiratory failure due to splinting; inability to clear secretions by effective coughing, with resulting pneumonia; and turning into a chronic pain: the post-thoracotomy pain syndrome. traditional pain management in these groups of patients - such as opiate treatment, thoracic epidural analgesia, and non-opioid drugs - may have serious side effects. large doses of opiates suppress the cough reflex and lead to respiratory depression with subsequent re-intubation and re-ventilation. thoracic epidural analgesia, though being considered paramount among other analgesic options, requires a significant clinical experience. still, it might be insufficient for satisfactory pain control and even complicated with pneumothorax, total spinal anaesthesia and inadvertent intravascular injection. non-steroidal anti-inflammatory drugs (nsaids) and tramadol are weak analgesics inadequate for severe pain control and might be responsible for gastrointestinal bleeding. we suggest performing erector spinae plane block for intraoperative and postoperative pain management due to the ease of use and better analgesic effect. what remains is hard proof for the clinical efficacy and safety of this block, followed by a demonstration of the uptake of it in the hands of non-regional anaesthetists.


Eligibility criteria:
inclusion criteria: * all consecutive adult patients who undergo thoracic, spinal or abdominal surgery in soroka medical center, and agree to participate in the study, older than 18 years, who meet criteria of asa physical status i-ii-iii-iv class. exclusion criteria: * unconscious or mentally incompetent patients or those who refuse to participate in the study.

Keywords: postoperative pain erector spinae plane block
treatment of forehead/glabellar rhytide complex with combination botulinum toxin a and hyaluronic acid versus botulinum toxin a injection alone

Conditions: Forehead/Glabellar Rhytid Complexes

Summary: the objective of this study is to determine whether the use of botulinum toxin (dysport ®) in conjunction with a hyaluronic acid filler (restylane®) will improve the appearance of wrinkles on the forehead and glabella (area between the eyebrows) better than botulinum toxin alone. these two products have been fda approved to improve the appearance of facial wrinkles.


Eligibility criteria:
inclusion criteria: * in good health * is 18-65 years of age * has static and dynamic forehead/glabellar wrinkles * has willingness and the ability to understand and provide informed consent and communicate with the investigator exclusion criteria: * pregnant or lactating * has received the following treatments in the forehead or glabellar region: * botulinum toxin injections in the past 6 months * ablative laser procedure in the past 6 months * radiofrequency device treatment in the past 6 months * ultrasound device treatment in the past 6 months * medium to deep chemical peel in the past 6 months * temporary soft tissue augmentation material in the past year * semi-permanent soft tissue augmentation material in the past 2 years * permanent soft tissue augmentation material * is planning to receive within the next 6 months, any cosmetic procedure (such as any chemical peels, botulinum toxin injections, ablative or non-ablative laser procedures, filler injections, radiofrequency procedures, dermabrasion, ultrasound and face lifting procedures) in the forehead or glabellar region. * is planning to use tretinoin or retinoic acid in the next 6 months * has an active infection in the forehead or glabellar region (excluding mild acne) * is allergic to cow's-milk protein * is allergic to albumin * taking aminoglycoside * has prior history of nodule formation or hypersensitivity reactions to lidocaine or hyaluronic acid derivatives * is currently using anticoagulation therapy * has a history of bleeding disorders * is unable to understand the protocol or to give informed consent * has a mental illness
endocrine and exocrine secretory function alterations after moderately severe and severe acute pancreatitis

Conditions: Acute Pancreatitis (AP); Diabetes Mellitus

Summary: the goal of this observational study is to learn about post-acute pancreatitis diabetes mellitus (ppdm-a). the main questions it aims to answer are: 1. are the incident rates of glucose metabolic disorders (pre-diabetes and diabetes mellitus) after acute pancreatitis of different etiologies the same? 2. are alterations in endocrine and exocrine secretory function in patients with acute pancreatitis associated with all-round outcomes? all patients with acute pancreatitis have been given the standardized treatment for the condition. investigators will compare the incident rates of glucose metabolic disorders (pre-diabetes and diabetes mellitus) after acute pancreatitis of different etiologies in patients with moderately severe (msap) and severe acute pancreatitis (sap) to explore the association between alterations in endocrine and exocrine secretory function and all-round outcomes.

investigators will prospectively collect data from patients with moderately severe (msap) and severe acute pancreatitis (sap) in participant centers.

Eligibility criteria:
inclusion criteria: 1. male or female chinese subjects; 2. age ≥18 years at the time of signing the informed consent; 3. patients with a complete diagnosis of msap and sap (according to the chinese guidelines for the diagnosis and treatment of acute pancreatitis 2019); 4. voluntary signatories of informed consent exclusion criteria: 1. patients with a history of diabetes mellitus or pre-diabetes mellitus, or glycosylated hemoglobin ≥ 6.0% or venous fpg ≥ 6.1 mmol/l at admission; 2. patients have any evidence of type 1 diabetes-related autoimmunity; 3. patients have any risk for secondary diabetes due to exposure to medications or other endocrine diseases; 4. combined with pancreas-related trauma or a history of pancreatic surgery; 5. patients undergo pancreatic surgery during treatment; 6. pregnancy or breastfeeding; 7. patients suffer from severe cardiac, hepatic or renal insufficiency or malignant diseases; 8. failure to sign informed consent due to cognitive impairment or other conditions

Keywords: acute pancreatitis diabetes mellitus ppdm-a risk factor
retrospective real-word study of linezolid for the treatment of tuberculous meningitis

Conditions: Tuberculous Meningitis

Summary: tuberculous meningitis (tbm) is the most serious form of mycobacterium tuberculosis infection, causing mortality and disability in more than half of the patients. current standard treatment for tbm is based on those developed to treat pulmonary tuberculosis, which does not take into account the differential ability of anti-tuberculosis drugs to penetrate the brain. with both good central nervous system penetrance and anti-tuberculosis efficacy that have been demonstrated in drug-resistant tuberculosis, linezolid may be a promising antimicrobial in tbm treatment. the purpose of this study is to evaluate the effectiveness of linezolid in the treatment of tbm.


Eligibility criteria:
inclusion criteria: * all patients diagnosed as tbm from the electronic medical record system. exclusion criteria: * does not meet the established diagnostic criteria; * combine other pathogen central infections; * follow-up confirmed that the final diagnosis considers other diseases (such as tumors, autoimmune encephalitis, etc.); * our hospital has less than one week of anti-tuberculosis treatment; * lack of information

Keywords: linezolid
insulin glulisine and aspart in postprandial glycemic control after high-gi meal in children with type 1 diabetes mellitus

Conditions: Type 1 Diabetes Mellitus

Summary: the aim of this study is to determine whether insulin glulisine is more effective in postprandial glycemic control than insulin aspart after the h-gi meal in children with type 1 diabetes (t1dm) treated with insulin pump (csii).

some studies have suggested that insulin glulisine (glu) has a slightly faster onset of action compared with insulin aspart (asp). meals of high glycemic index (h-gi) have distinct effect on postprandial glycaemia (ppg).

Eligibility criteria:
inclusion criteria: * type 1 diabetes mellitus * csii for at least 3 months * duration of diabetes \> 1 years * informed consent exclusion criteria: * concomitant dietary restrictions (e.g. celiac disease or food allergy) * diabetes related complications * baseline hyperglycemia \>150 mg/dl * any disease judged by the investigator to affect the trial

Keywords: diabetes insulin pump glulisine aspart glycemic index