Kornimate/medical-research-clean huggingface dataset:
subclinical hypothyroidism and chronic inflammation in pcos

Conditions: PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries; Subclinical hypothyroïdism; Hypothalamic-Pituitary-Gonadal Axis Dysfunction

Summary: chronic inflammation in polycystic ovary syndrome (pcos) may be the result of dysregulation of cytokine production (due to insulin resistance, excess visceral fat and hyperandrogenemia), i.e., overproduction of pro-inflammatory factors (e.g. tnf, il-1, il-6) in relation to anti-inflammatory ones (il-10). this condition may be an important link between obesity and insulin resistance, which is crucial in the etiopathogenesis of the syndrome. however, it is not known whether it results from the tendency to accumulate adipose tissue or is a feature of the syndrome itself. concomitant endocrinopathies, i.e. obesity, dyslipidemia, insulin resistance, diabetes and thyroid diseases, may additionally influence the activity of chronic inflammation. there is no data indicating the relationship between chronic inflammation and pcos phenotypes, the severity of metabolic disorders, ovarian reserve and the influence of thyroid function on its activity in pcos.

the aim of the study is: i) to assess and compare serum concentrations of selected inflammatory markers (leucocytosis, crp, procalcitonin, fibrinogen, ferritin, il-1, il-6, il-10, tnf-alpha) in women with different phenotypes pcos and hypothalamic-pituitary-ovarian axis dysfunction (hpod) (control), ii) to evaluate the impact of subclinical hypothyroidism (defined as tsh\>2.5 uiu/ml, ft3 3,1-6,80 pmol/l, ft4 12,0-22,0 pmol/l), with the presence and absence of circulating antithyroid antibodies (a-tpo and a-tg), on the balance between anti- and pro-inflammatory factors in women with different pcos and hpod phenotypes, iii) to assess the impact of imbalance between anti- and pro-inflammatory factors in women with different pcos and hpod phenotypes on ovarian reserve indices, expressed as fsh and amh concentrations. the study population will be characterized in terms of demographic (age, bmi), gynecological (age of first and last menstrual period, cycle length, history of reproductive organ surgeries, ultrasound measurements of endometrial width, ovarian volume) and obstetrics (pregnancies, childbirth, miscarriages) data. pcos syndrome (and its phenotypes) will be recognized by the rotterdam criteria. hpod will be diagnosed according to who criteria. during hospitalization, blood samples will be collected for scheduled analyzes (30 ml of blood in total).

Eligibility criteria:
inclusion criteria: * age 18-45 years, * cycle length \ 35 days, * unsuccessful attempts to conceive for at least 12 months of regular intercourse with sonographically confirmed anovulation with excluded male, tubal and uterine infertility factors. exclusion criteria: * absence of at least one ovary, * previously diagnosed thyroid disease
heart rate variability after ablation

Conditions: Atrial Fibrillation

Summary: pulsed-field catheter ablation is a promising new treatment method for patients with atrial fibrillation. the mechanism of cell damage here is different from that of classic catheter ablation, in which the ganglion plexuses around the pulmonary veins are also damaged and thus changes in the autonomic nervous system occur. the aim of the work is to find out, using heart rate variability, whether the autonomic system is less affected during pulsed field ablation than in classic radiofrequency ablation.

catheter ablation for pulmonary vein isolation (pvi) is the most effective treatment method for atrial fibrillation (af). for a long time, radiofrequency energy (rfa) was dominantly used for ablation, which leads to tissue heating and thus thermal damage. the methodology of pulsed-field ablation, or irreversible electroporation, has been completely newly developed. this form of energy does not lead to thermal tissue damage (as is the case with radiofrequency energy), but with the help of high-intensity nanopulses of electrical energy, the ion channels of cardiomyocytes are permanently opened, the concentration gradient of ions is canceled and thus their irreversible destruction. in addition to the electrical isolation of the pulmonary vein, standard radiofrequency isolation of the pulmonary veins leads to the ablation of collateral ganglion plexuses and thus to the influence of the autonomic nervous system. this is very positive, an imbalance between sympathetic and parasympathetic innervating the left atrium is considered a risk factor for af induction, and its damage with standard rfa is considered part of the rfa ablation effect. available studies suggest that pfa probably induces significantly weaker and less permanent suppression of cardiac autonomic regulation compared to rf energy used for pvi. measuring heart rate variability is a simple non-invasive method. a regular ecg holter recorder can be used for the measurement. patients will be fitted with a 24-hour holter ecg on admission to determine the original heart rate variability. catheter ablation will take place the next day. patients will be treated using one of two methods of pulmonary vein isolation - rfa or pfa. one month after the catheterization procedure, a 24-hour holter ecg will be used again to detect changes in hrv compared to preoperative values.

Eligibility criteria:
inclusion criteria: * paroxysmal atrial fibrillation * indication for catheter ablation due to atrial fibrillation * willingness to participate exclusion criteria: * atrial fibrillation throughout holter ecg recording * significant valve disease * left ventricular dysfunction, ef less than 35%

Keywords: atrial fibrillation heart rate variability pulsed field ablation radiofrequency ablation
minocycline to reduce pain after carpal tunnel release

Conditions: Chronic Pain; Post-operative Pain

Summary: the investigators are looking at whether peri-operative minocycline will reduce the duration of pain after minor hand surgery: carpal tunnel release and trigger finger release. the investigators' hypothesis is that minocycline will reduce post-operative pain.

this is a double blinded randomized controlled trial. patients are given 100mg of minocycline 2 hours prior to their procedure and then 100mg two times a day for 5 days. the subjects are then contacted daily to check their level of pain. the investigators' outcome of interest is time to pain resolution. the investigators will perform a futility analysis to assess if a larger trial would be a reasonable next step after this pilot study.

Eligibility criteria:
inclusion criteria: * adult, veteran, exclusion criteria: * kidney failure, liver failure, thrombocytopenia, als, sle, frailty, unable to understand survery
comparison of premixed insulins aspart 30, aspart 70 and aspart on postprandial lipids

Conditions: Type 2 Diabetes

Summary: the aim of the study is to investigate meal-related treatment with either premixed insulin aspart 30, aspart 70 and aspart with regard to postprandial glucose, triglyceride and free fatty acids excursions after a standard breakfast and lunch.

whereas the effects of each of the established types of insulin (remixed insulin aspart 30, aspart 70 and aspart) have been shown before, their specific glucose and lipid lowering capacities have so far not been investigated in a simulated physiological situation.

Eligibility criteria:
inclusion criteria: * type-ii diabetes * bmi \> 27 kg/m2 * age 35 to 75 years * hba1c \< 8.5% * informed consent * treatment with pre-mixed insulin * stabile dose of insulin for at least 4 weeks exclusion criteria: * type-i diabetes mellitus * hba1c \> 8.5 % * serum creatinine \> 1.7 mg/dl * alaninaminotranferase or aspartataminotransferase \> 3x upper limit of normal * treatment with sulfonylurea or gliptins * treatment with glitazones * manifest clinical infections * treatment with glucocorticoids or antipsychotic drugs * psychiatric diseases * alcohol abuse * myocardial infarction or stroke within the previous 3 months * surgery within the previous 3 months

Keywords: insulin aspart 30 insulin aspart 70 insulin aspart postprandial glucose and lipid metabolism consecutive mixed meals
central venous oxygen saturation and carbone dioxide (co2)-derived indices in the critically:

Conditions: Shock

Summary: the optimal management of shock states requires a precise evaluation of several parameters, clinical, biological, hemodynamic, and echocardiographic. among these, parameters that measure o2 and co2 consumption are of a great interest, especially pco2 arteriovenous gradient (pco2 gap) and o2 arteriovenous difference \[d(a-v) o2\]. the pco2 gap best correlates with cardiac output while the pco2gap/d(a-v)o2 ratio would be earlier and more specific than blood lactate assay in assessing tissue hypoperfusion secondary to shock. the pco2 gap and the pco2gap/d (a-v) o2 ratio have been evaluated from gas measurements of venous blood collected from the pulmonary artery and from the superior vena cava area. however, in some patients the placement of a catheter in the superior vena cava is difficult or even impossible due to thrombosis, vascular occlusions and other reasons... in these cases, the inferior vena cava is used for drugs infusion, nutrition and possibly samples. gasometric samples in lower cellar territory have not yet been validated and may not be correlated with measurements in upper cellar territory. it is therefore useful for current practice to validate samples in lower cellar territory and demonstrate their correlation with measurements made in upper cellar territory. during an observation period, in patients with catheters in the superior and inferior vena cava for therapeutic indications (renal replacement therapy,...), the investigators systematically took gas measurements at the femoral and jugular sites. the investigators used these data to assess the correlation of pco2 gap measurements and carbon dioxide-derived indices according to the harvest site : jugular and femoral venous.


Eligibility criteria:
inclusion criteria: - all consecutive critically ill patients who had an arterial catheter and a venous catheter in the superior and inferior vena cava were included. exclusion criteria: * an age under 18 * pregnancy * legally protected adults

Keywords: adult > 18 yo venous catheter in femoral and jugular sites arterial catheter central venous to arterial carbon dioxide difference central venous to arterial carbon dioxide difference to arterial to venous oxygen difference central venous oxygen saturation
inspiratory muscle training with powerbreath device in patients with fibromyalgia

Conditions: Fibromyalgia

Summary: context/background: people affected by fibromyalgia see their own life totally disturbed after the diagnosis. this disease also courses, apart from the functional and depressing worsening, with internal damage manifested by a cardio respiratory deterioration. there are not many clinical studies publications about this disease given that is considered a weird illness with short prognosis. objectives: to examine the effects of the inspiratory muscle training (imt) on respiratory muscle strength, lumbar pain, quality of life, phase angle and body composition in patients with fibromyalgia. the participants of experimental group will conduct 5 sets of 10 inspirations per day, 5 days per week, through 8 weeks.

methods: 40 volunteer patients, female, with fibromyalgia will take part of the cuasi-experimental study and they will be divided into two groups: an experimental group (n = 20) and a control group (n = 20). the maximum inspiratory pressure (pim), the quality of life, lumbar pain, phase angle and body composition will be measured. inspiratory muscle training with powerbreath imt device, for a duration of 8 weeks. each day, each subject perform 5 sets of 10 inspirations, 5 days a week. the endurance of the device increases along the study, initiating with the 50% of their own maximum inspiratory pressure (mip) during the first week, 2nd week: 55% mip, 3rd week: 60% mip, 4th week: 65% mip, 5th week: 70% mip, 6th week: 75% mip, 7th week: 80% mip and 8th week:80% mip after 8 weeks, all participants will fill up again all scales and post training measurements will be taken.

Eligibility criteria:
inclusion criteria: * subjects with fibromyalgia exclusion criteria: -
analgesic effect of repetitive transcranial magnetic stimulation (rtms) for central neuropathic pain in multiple sclerosis

Conditions: Multiple Sclerosis With Central Neuropathic Pain

Summary: this study is designed to evaluate the effect of repetitive transcranial magnetic stimulation (rtms) in the resolution of chronic pain. participants will be patients with multiple sclerosis suffering from chronic pain of neurological origin.

on the one hand, multiple sclerosis (ms) is the most frequent chronic disease generating neurological disability in young adults. among the many types of disabilities associated with ms, chronic pain is very frequent, especially neuropathic pain. this type of pain is often treatment resistant. moreover, abnormal intra-cortical excitability has been described in ms patients. on the other hand, repetitive transcranial magnetic stimulation (rtms) has shown an analgesic effect in various chronic pain conditions (fibromyalgia, post-stroke, peripheral neuropathic pain). three groups have shown that analgesia was correlated to defective intra-cortical excitability restoration. the goal of this study is to compare the analgesic effects of two types of primary motor cortex (m1) rtms, namely 10hz and prolonged continuous theta-burst stimulation (pctbs), with sham stimulation. patients will benefit from 1 daily session per day for 5 consecutive days and from a total follow up of 4 weeks. pain will be assessed each day and several other signs and symptoms will be repeatedly assessed.

Eligibility criteria:
inclusion criteria: * relapsing-remitting multiple sclerosis * 18 to 60 years * central neuropathic pain with a dn4 score of 4 or more out of 10 * average pain of at least 4/10 * presence of pain at least 4 days per week * presence of pain for at least 3 months * stable analgesic treatment exclusion criteria: * relapse during the previous 30 days * contraindication for rtms * peripheral neuropathic pain * severe depression * epilepsia * resting motor threshold above 75%

Keywords: multiple sclerosis repetitive transcranial magnetic stimulation (rtms) chronic neuropathic pain cortical excitability
lancet blood volume comparison study

Conditions: Diabetes

Summary: the primary objective of the study examines the success rate of various onetouch delica lancet sizes across depth settings of the onetouch delica lancing device. the sample size is based on 30 subjects per lancet size for a given depth setting. each subject is lanced 4 times with two lancet sizes at a single depth setting. there will be 120 paired lancing events for each lancet size within the group. null hypothesis (h0): there is a 90% success rate of attaining a minimum blood volume of 1.0μl for the 28g lancet across all depth settings. alternate hypothesis (h1): the success rate of attaining a minimum blood volume of 1.0μl for the 28g lancet across all depth settings is less than 90%.


Eligibility criteria:
inclusion criteria: * must have been diagnosed with type 1 or type 2 diabetes for at least 1 year * must be doing blood glucose monitoring, at least twice daily for at least 6 months * subjects must be between 18 and 85 years of age. * subjects must be able to perform all tasks required in this protocol. * subjects must be willing to complete all study procedures. * subjects must be able to speak, read and understand english and understand the informed consent document. exclusion criteria: * subjects with neuropathy or any other nerve damage in the hand or fingers * subjects who are taking prescription anti-coagulants or more than one full aspirin per day during the past week or have clotting problems that may prolong bleeding (persons taking plavix or a daily low dose aspirin will not be excluded but this will be recorded). * subjects taking prescription medications for neuropathy. * subjects with hemophilia or any other bleeding disorder. * subjects with infection with a blood borne pathogen (e.g., hiv, hepatitis). * subjects having a condition such as a cognitive disorder, which in the opinion of the investigator would put the person at risk or seriously compromise the integrity of the study (pi will sign case report form if subject is excluded). * subjects working for facet, lifescan inc., or a competitive company. * subjects with missing digits. * subjects who are pregnant or nursing. * subjects on chemotherapy. * subjects with poor circulation to the hands as judged by a refill time of more than 5 seconds
effect of non-invasive magnetic stimulation of the brain on breathlessness in healthy individuals.

Conditions: Dyspnea

Summary: the purpose of this study is to see if the front part of the brain called the "dorsolateral prefrontal cortex" (dlpfc) has a role in our ability to feel breathlessness. the experiment will use a device that sits on the top of the head which produces a magnetic field that penetrates the scalp and excites the brain tissue directly under it. this procedure is called repetitive transcranial magnetic stimulation (rtms), it is a painless procedure and known to be safe in healthy individuals. previous research has shown that the pain felt when capsaicin, the active ingredient in 'chilli' powder, is applied to the hand is reduced by applying the rtms on the scalp directly above the dlpfc part of the brain. in this experiment we want to see if breathlessness is also reduced. we will use a breathing task that will generate a moderate amount of breathlessness by adding a small amount of carbon dioxide to the inhaled air, while preventing the increase in the amount of breathing we would normally see in response to this. if we find that breathlessness produced by this breathing task is reduced after rtms over the dlpfc, this may lead to new drugs that target this part of the brain in patients suffering from breathlessness due to heart or lung disease. the study will also improve our knowledge of how the brain enables us to feel breathlessness


Eligibility criteria:
inclusion criteria: healthy individuals, over 18 years old, with no history of heart, lung or neurological conditions exclusion criteria: * any history of respiratory problems (including asthma that involves regular use of inhalers) * any history of heart or circulatory problems (e.g. palpitations, arrhythmias, angina, bp) * any history of epilepsy, convulsions or seizures, migraines, or fainting * any history of anxiety disorders (e.g. panic attacks) * any history of serious head injury or brain surgery * any metal parts in the head (except dental wire) * any implants (e.g. pacemaker, insulin pump, neurostimulator) * pregnancy or problems with alcohol or drug abuse.

Keywords: air hunger
comparison of mcgrath and macintosh laryngoscopes for insertion of a double lumen tube by residents

Conditions: Thoracic Injuries

Summary: the insertion of double lumen tube is difficult even more if it is a resident with no experience. we think that using videolaryngoscopes for novice ones would facilitate insertion of double lumen tube thanks to the visualization on a lcd screen of the laryngeal structure.


Eligibility criteria:
inclusion criteria: * thoracic surgery * insertion of double lumen tube exclusion criteria: * emergency surgery * risk of inhalation * person unable to consent * persons deprived of liberty, under guardianship or trusteeship * pregnant or lactating woman * allergy to tracrium, propofol, sufentanil

Keywords: mac grath double lumen tube
preferences in pain treatment: a discrete choice experiment in patients with peripheral neuropathic pain (pnp)

Conditions: Neuralgia Peripheral; Neuropathic Pain; Patient Preference

Summary: the objective of this study is to identify and weight attributes of topic and systemic pain treatment options relevant from the patients' perspective with peripheral neuropathic pain. the study will use a discrete choice experimental design to reach its objective.


Eligibility criteria:
inclusion criteria: * patients with diagnosed peripheral neuropathic pain (pnp) as assessed by study sites exclusion criteria: * patients with no sufficient knowledge in written or oral german as assessed by study sites

Keywords: discrete choice experiment
long term outcome in icu treated covid-19: new chronic diseases

Conditions: Covid19

Summary: additional chronic diseases one year after intensive care unit (icu) admission with coronavirus disease 2019 (covid-19) will be assessed in comparison to two control cohorts. the icu population comprises all swedish icu patients with covid-19 with at least one year of follow up. the hospital admitted cohort comprises four hospital admitted patients with covid-19 per icu patient, matched on age, legal gender and region. the general population controls are matched to the icu patients in a one to four fashion on age, legal gender and region. icu patients are identified in the swedish intensive care registry. the hospital admitted patients are identified in the national patient registry and the population controls are identified in the population registry. data on comorbidity, medications and death are provided from the national board of health and welfare.


Eligibility criteria:
inclusion criteria: * admitted to a swedish icu and registered in the swedish intensive care registry with the icd 10 diagnosis u07.1 before 1 july 2020. icu-cohort. or randomly selected from all patients admitted to hospital but not icu with the icd 10 diagnosis u07.1 in the national patient registry, matched on age, legal gender and region (four per icu patient) before 1 july 2020. hospital cohort. or randomly selected from the general population (and not included in the icu or hospital admitted cohorts), matched on age, legal gender and region (four per icu patient) exclusion criteria: * missing a swedish personal identification number

Keywords: long term outcome mortality covid-19 morbidity