Kornimate/medical-research-clean huggingface dataset:
an investigation of heart rate recovery responses to repeated active stand protocols

Conditions: Heart Rate Response; Orthostasis

Summary: study background: impaired heart rate recovery following active stand is associated with morbidity and mortality. evidence for the repeatability of this measure is limited. this study seeks to determine the repeatability of the active stand procedure in eliciting heart rate recovery in healthy adults of all ages. research aims: the aims of this study are to determine the repeatability of heart rate recovery in response to the active stand procedure among different age groups. study design: this will be a repeatability study with between group comparison. study setting: this study will take place in the clinical research facility in st james's hospital. participants: participants will be recruited from the staff and student population of trinity college dublin and st james's hospital, from the trinity retirement association and from the community in the st. james's hospital catchment area. participants will be healthy adults (over 18 years old). they will be invited to participate via an email and poster campaign. participation will be fully voluntary. participants who meet inclusion criteria will be selected. informed, explicit voluntary consent will be obtained from each participant. data collection and processing: data collection and processing will be carried out by the research physiotherapist. a clinical visit for the participant will be arranged at a time most convenient for them. participants will conduct the active stand assessment on three occasions.


Eligibility criteria:
inclusion criteria: * healthy adults aged ≥18 (considering 18 is the age of legal consent). * fluent in english. * free of intellectual disability or cognitive impairment that would impair or impede the ability to give informed, explicit consent. * free of all exclusion criteria below. exclusion criteria: * unstable or un-managed cardiac/respiratory/metabolic conditions (i.e. condition must be diagnosed and being managed as per medical input to be classified as stable and managed). * neuro- musculoskeletal disorders. * acute musculoskeletal injury or impairment (including acute pain). * malignancy. * mental illness. * chronic infectious disease (hep c/ hiv/ aids). * acute systemic infection or illness. * taking medication that affects cardiovascular function. * exclusion for any other reason deemed appropriate by the research team.

Keywords: heart rate response active stand
the outcomes of arteriovenous fistula cannulated from different direction.

Conditions: Arteriovenous Fistula

Summary: the investigators hypothesis that aneurysms and stenoses will be decreased if the direction of inserted arterial needle were same as the direction of blood flow, when compared to the opposite direction puncture.

native arteriovenous fistula (avf) is the preferred access for hemodialysis, and cannulation technique is very important factors affect the outcomes of avf. rope-ladder cannulation is one kind of the standard puncture techniques which is used commonly in maintenance hemodialysis (mhd) patients. there are many complications for rope-ladder cannulation, such as venous aneurysm and vascular stenosis, which may induce avf dysfunction. for the venous outflow way, there always be aneurysm followed by stenoses at the sites of needle connected with the arterial line in rope-ladder cannulation patients. the investigators hypothesis that the directions of inserted arterial needles should affect the avf outcomes. the present prospective study will compare the outcomes of avf between the puncture direction at arterial needle sites same as blood flow and opposite to blood flow.

Eligibility criteria:
inclusion criteria: * mhd patients with autogenous avf. * newly setup avf in 3 months. * fore- or upper arm avf. * flow of \>800ml/min detected by using the ultrasound dilution technique. exclusion criteria: * avf after neoplasty. * arteriovenous grafts. * anticipated live time less than one year. * patients whose concurrent illnesses, disability, or geographical residence would hamper attendance at required study visit.

Keywords: arteriovenous fistula hemodialysis aneurysm vascular stenosis cannulation
a study of mabthera/rituxan (rituximab) in patients with follicular non-hodgkin's lymphoma

Conditions: Non-Hodgkin's Lymphoma

Summary: this single-arm, open-label, multi-centre study will evaluate the efficacy and safety of mabthera/rituxan (rituximab) in patients with follicular non-hodgkin's lymphoma with minimal residual disease after autologous haematopoietic stem cell transplantation (bone marrow or peripheral blood). two groups of patients will be considered for treatment. group a: patients with evaluable minimal tumor mass, group b: patients with complete response and abnormal b-cell lymphoma 2 (bcl2) status. patients will receive mabthera/rituxan 375 mg/m2 intravenously once every week. the anticipated time on study treatment is 4 weeks.


Eligibility criteria:
inclusion criteria: * adult patients, 18-75 years of age * diagnosis of follicular non-hodgkin's lymphoma (fnhl) * previously treated with chemotherapy with autologous haemotopoietic stem cell transplantation (bone marrow or peripheral blood cells) exclusion criteria: * active viral hepatitis * eastern cooperative oncology group (ecog) performance status \>2 * patients not willing to sign informed consent form
pilot study of sodium nitrite in resuscitated cardiac arrest patients

Conditions: Cardiac Arrest

Summary: despite advances in cardiac arrest resuscitation survival from cardiac arrest is less than 20-30% and new therapies are urgently needed. sodium nitrite infused during resuscitation from cardiac arrest has recently been shown to improve survival in a mouse model of cardiac arrest and our group is eager to test this hypothesis in a clinical trial. our overall hypothesis is that an infusion of 2 μmole/kg sodium nitrite during resuscitation will increase the proportion of patients who will survive cardiac arrest. in preparation for a clinical trial, preliminary safety and efficacy data (phase 1) is needed which is the primary goal of this study.

sixteen patients will be randomized to receive normal saline (n=5) or doses of iv nitrite (n=11). during the nitrite infusion and for 120 min after the infusion is completed, blood pressure and heart rate will be monitored. the first 3 patients randomized to receive iv nitrite will receive the lowest dose (1 mg) of iv nitrite and compared to one placebo treated patient. if there is no significant decrease in blood pressure or elevation in heart rate, we will then dose escalate to the 6 mg dose in 4 patients and placebo in two patients. dose escalation to the highest (14 mg) dose will again be contingent on the absence of significant hypotension or tachycardia in the drug treated patients compared to the pooled (n=3) placebo treated patients. the final block of patients will be randomized to the high nitrite dose (n=4) or placebo (n=2). final comparisons of all groups will be made to the pooled (n=5) placebo group

Eligibility criteria:
inclusion criteria: * successfully resuscitated from cardiac arrest by paramedics in the field age 18 or older comatose iv access exclusion criteria: * traumatic cause of cardiac arrest known dnar patient requiring vasopressors at time of randomization sbp \<105 pao2 of less than 90% on fio2 of 1.0

Keywords: cardiac arrest ventricular fibrillation nitrite
vr high tech pain control burn wound care

Conditions: Pain; Burn

Summary: using virtual reality as a form of distraction for pain during wound care. virtual reality involves looking into a set of goggles and then moving through a computer-simulated world.

this study has three different groups. patients will be randomly assigned to one of three groups (two treatments and one control). treatment for group 1 is virtual reality distraction during wound care. group 2 will listen to an audio recording called "sounds of nature". group 3 will be the control group. subjects in all three groups will receive the following questionnaires: graphic rating scale mcgill short-form pain questionnaire sullivan catastrophization scale (only on day 1/baseline) the nurse grs

Eligibility criteria:
inclusion criteria: * age greater than or equal to 18 years * compliant and able to complete questionnaires * no history of psychiatric disorder * not demonstrating delirium, psychosis or any form of organic brain disorder * able to communicate verbally * english-speaking exclusion criteria: * age less than 18 years * not capable of indicating pain intensity * not capable of filling out study measures * evidence of traumatic brain injury * history of psychiatric disorder * demonstrating delirium, psychosis or any form of organic brain disorder and associated memory problems * unable to communicate orally * receiving prophylaxis for alcohol or drug withdrawal * developmental disability * any face/head/neck injuries that interfere with the use of virtual reality equipment * non-english speaking * extreme susceptibility to motion sickness * seizure history

Keywords: vrd virtual reality as distraction during procedure burn wound care
electrochemical skin conductance in evaluation of chronic neuropathy électrochimique cutanée

Conditions: Difference, Individual

Summary: use of cutaneous electrochemical conductance for preclinical screening of small-caliber nerve fibers

objective: use of cutaneous electrochemical conductance for preclinical screening of small-caliber nerve fibers background: sudoscan is a tool developed to evaluate and screen peripheral neuropathies in diabetes. his indication has been extended to other neuropathies such as post-chemotherapy, fabry's disease, parkinson's disease, familial amyloid polyneuropathy. main objective: evaluation of the relevance of cutaneous electrochemical conductance in chronic peripheral neuropathies. methodology : recruitment of 2 groups of 2000 patients group 1: patients with chronic neuropathy, during clinic bread consultation group 2: patients to benefit from scheduled surgery seen during anesthesia consultation for both groups filling the central awareness inventory questionnaire analysis of the results after the recruitment has been completed.

Eligibility criteria:
inclusion criteria: * adult exclusion criteria: * patients group : not have a chronic neuropathy
glucose response in persons with type 2 diabetes

Conditions: Diabetes Mellitus, Type 2

Summary: this will be a randomized crossover design with oral nutrition supplement interventions.

this will be a randomized crossover design with two oral nutrition supplement interventions. the subjects will be randomized to one of two interventions on two separate study days, one week apart.

Eligibility criteria:
inclusion criteria: * age 20-75 years * type 2 diabetes controlled with diet or diet and metformin (glucophage) * hemoglobin a1c less than 9.0% * fasting blood glucose less than 180 mg/dl * hematocrit levels within normal limits * having obtained his/her informed consent exclusion criteria: * abnormal thyroid function * creatinine \>2.0 mg/dl * potassium \<3.5 meq/l * gastrointestinal disease: ulcer, gastritis, diarrhea, gastroparesis, vomiting * currently unstable diabetes or under treatment for cancer, heart disease, renal disease * patients with anemia * current insulin therapy or insulin therapy within the past month * patient who are pregnant * allergies to milk, soy or any component of the test product * patient who in the investigators assessment cannot be expected to comply with treatment * patients with anemia * currently participating in another clinical trial
a comparative study of the effectiveness of treatment of contractures with mechanically applied stretch and heat.

Conditions: Cerebral Palsy

Summary: this study is looking at new ways to stretch knee contractures in children with cerebral palsy using a specially designed splint.

when using active orthoses to treat contractures, is the effectiveness of treatment improved by heating the contracted tissue prior to treatment?

Eligibility criteria:
inclusion criteria: children with cerebral palsy - exclusion criteria: absent thermal sensation -

Keywords: cerebral palsy dynamic splinting contractures heat therapy
comparison of three types of sutures in oral surgery. study of bacterial colonization, tissue reaction and clinical characteristics: randomized clinical study

Conditions: Wound Healing Complication; Oral Surgery; Third Molar Extraction; Oral Infection

Summary: considering the wide variety of surgical sutures currently marketed in the field of dentistry, it was decided to conduct a study comparing the microbial adhesion and antibacterial activity of three different types of sutures used in oral surgery (silk, non-absorbable polyamide monofilament and non-absorbable expanded polytetrafluoroethylene).

the general or primary objective is: • to compare 3 non-absorbable suture materials used in oral surgery: silk, polyamide monofilament and expanded polytetrafluoroethylene. the specific or secondary objectives are: * to evaluate how each type of suture influences wound healing and the patient's postoperative period. * to study bacterial colonization in each type of suture. * to determine the tissue reaction and clinical characteristics of each suture.

Eligibility criteria:
inclusion criteria: * patients with indication for extraction of a third lower molar retained in an unfavorable position that requires a bayonet incision in the surgical procedure. * age: patients aged 18 years or older. * asa i patients (classification of the american society of anesthesiology, 1979): healthy patients who tolerate stress well, without systemic pathology, no anxiety and in whom a therapeutic modification is not necessary. exclusion criteria: * pregnant or breastfeeding women. * smoking patients.
a comparative analysis of prognostic factors for functional outcomes in patients with acute subdural hematoma

Conditions: Acute Subdural Hematoma; Acquired Brain Injury

Summary: acute subdural hematoma (asdh) is the most common intracranial traumatic lesion that requires surgical intervention. although there is extensive published research on acute subdural, there remains uncertainty regarding mortality risk and functional outcomes for patients. this study aims to evaluate the effectiveness of contemporary scoring systems in different age groups of asdh patients to predict functional outcomes.

acute subdural hematoma (asdh) is the most common intracranial traumatic lesion that requires surgical intervention. although there is extensive published research on acute subdural, there remains uncertainty regarding mortality risk and functional outcomes for patients. this study aims to evaluate the effectiveness of contemporary scoring systems in different age groups of asdh patients to predict functional outcomes. it is our belief that this research will provide valuable insights on the risk of mortality and functional outcomes for asdh patients. several clinical and radiologic factors have been identified within the general population that correlate with mortality rates and functional outcomes. there are a number of factors that must be considered in the evaluation of a patient with traumatic brain injury, and a comprehensive assessment is necessary to determine the best course of treatment.

Eligibility criteria:
inclusion criteria: * surgery due to asdh * 12 months of follow-up * functional outcome measured by the glasgow outcome scale extended (gose). exclusion criteria: * none

Keywords: acute subdural hematoma intracranial hemorrhage prognosis functional outcome
effect of release of upper track of deep front facial line versus myofascial release with iastm on patients with upper cross syndrome

Conditions: Upper Cross Syndrome

Summary: this study will be conducted to compare the effect of release of upper track of deep front facial line versus myofascial release with iastm on patients with upper cross syndrome.

upper cross syndrome is a postural dysfunction that can cause a variety of upper-body musculoskeletal problems. early detection and physiotherapy can help to prevent further complications. maintaining bad posture over an extended duration can cause postural dysfunction and misalignment. the first and most obvious sign of upper crossed syndrome is the characteristic postural dysfunction of protracted scapulae, medially rotated humeri, hyperkyphotic upper thoracic spine, and a protracted/ anteriorly held head, which is created by hypo lordosis or even kyphosis (excessive flexion) of the lower cervical spine, hyper lordosis of the upper cervical spine and head, and anterior translation of the head upon the atlas. the available treatments for upper cross syndrome are stretching, strengthening, myofascial release, postural relaxation exercise, electrical stimulations, and deep neck flexors activations are the most used techniques. numerous studies have highlighted various benefits in terms of time efforts, and prognosis. those are corrective exercise, kinesio taping, scapular stabilization exercise, and pnf techniques. studies have demonstrated the role of fascia in various musculoskeletal dysfunctions as the fascial tissues connect the skeletal muscles forming a body-wide web in a pattern called myofascial meridians. as fascia is able to modify its tensional state, strain transmission along the meridians might occur in response to changes in muscle activity. deep fascia tends to be highly vascularized and contain well developed lymphatic channels. in some instances, deep fascia can even contain free encapsulated nerve endings, such as ruffini and pacinian corpuscles. it is present in our body in different tissue planes and in different forms with specific function and the musculoskeletal fascial system can be affected by various localized disorders with variable time course and prognosis.

Eligibility criteria:
inclusion criteria: * age between 18-40 years old * all participants had forward head, craniovertebral angle \< 50. * all participants had rounded back (kyphosis angle ≥ 42°) * based on assessment of upper cross syndrome by photogrammetric analysis. * the subjects were chosen from both genders. exclusion criteria: * history of trauma or surgery in cervical region. * bone fractures or acute soft tissue injuries. * osteoporosis. * heart attack. * unstable angina pectoris -implanted pacemaker or defibrillator- -cancer- * rheumatoid arthritis * connective tissue disease: this includes diseases such as osteomyelitis, lupus and scleroderma -neurological conditions-

Keywords: upper cross syndrome iastm release of upper track of deep front facial line
safety and efficacy of tegaserod in opioid-induced constipation in patients with non-cancer pain.

Conditions: Opioid-induced Constipation

Summary: this study will evaluate the safety and efficacy of tegaserod in opioid-induced constipation (oic) in patients with non-cancer pain. patients who enter this study prior to the core study (chtf919n2201) interim analysis (ia) receive the treatment as follows: patients on tegaserod 6 mg twice daily (b.i.d.) or 12 mg once daily (o.d.) in the core study will remain on the same dose in the extension (double-blind). patients on placebo during the core study will receive tegaserod 12 mg o.d. (open-label) patients who enter this study after the core study interim analysis will receive the selected tegaserod dose regimen (open-label) determined by the core study ia.


Eligibility criteria:
inclusion criteria: * patient has completed the 12 week double blind treatment of study chtf919n2201 exclusion criteria: * planned discontinuation of opioids during the study. * development of any of the medical conditions listed as exclusion criteria for the chtf919n2201 study. other protocol-defined inclusion/exclusion criteria may apply

Keywords: opioid, constipation, tegaserod
carboplatin and paclitaxel in treating older patients with metastatic or recurrent unresectable non-small cell lung cancer

Conditions: Lung Cancer

Summary: rationale: drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. combining more than one drug may kill more tumor cells. purpose: phase ii trial to study the effectiveness of carboplatin and paclitaxel in treating patients who have metastatic or recurrent unresectable non-small cell lung cancer.

objectives: i. determine the response rate to carboplatin and paclitaxel in elderly patients with metastatic or recurrent unresectable non-small cell lung cancer. ii. determine the toxicity of this regimen in these patients. iii. determine if the hypothesized lack of social support impacts the recruitment of elderly patients into clinical trials. iv. determine if a previously validated tool of functional status in the elderly predicts treatment related toxicity superior to that predicted by the ecog performance status in this patient population.

Eligibility criteria:
disease characteristics: histologically or cytologically confirmed non-small cell lung cancer stage iv disease or recurrent unresectable disease no other conventional curative or significant palliative therapies available measurable disease at least one lesion a minimum of one dimension in diameter of at least 20 mm no symptomatic and/or untreated cns metastases patient characteristics: age: 65 and over performance status: ecog 0-2 life expectancy: at least 12 weeks hematopoietic: absolute neutrophil count at least 1,500/mm3 platelet count at least 100,000/mm3 hepatic: ast no greater than 3 times upper limit of normal renal: creatinine clearance at least 40 ml/min other: no uncontrolled infection no uncontrolled seizure disorder no uncontrolled diabetes mellitus no other malignancies within the past 3 years except adequately treated basal or squamous cell skin cancer or noninvasive carcinomas prior concurrent therapy: biologic therapy: no prior biologic or immunotherapy for recurrent or metastatic disease no concurrent biologic therapy chemotherapy: no prior chemotherapy for recurrent or metastatic disease except as radiosensitizer no other concurrent chemotherapy endocrine therapy: not specified radiotherapy: no prior radiotherapy for recurrent or metastatic disease except as adjuvant therapy at least 4 weeks since prior radiotherapy to greater than 25% of bone marrow no concurrent radiotherapy except for cns therapy surgery: see disease characteristics at least 3 weeks since prior major surgery

Keywords: recurrent non-small cell lung cancer stage iv non-small cell lung cancer
vancomycin serum concentrations in pediatric oncology patients under intensive care

Conditions: Infection

Summary: observational protocol to analyse routine vancomycin serum levels of patients under intensive care and to obtain percentage of patients that achieve therapeutic values.


Eligibility criteria:
inclusion criteria: * hospitalized pediatric oncology patients * patients under vancomycin treatment
implicit learning in epileptic children

Conditions: Epilepsy

Summary: epileptic children suffer from impairments in various learning and memory tasks. yet, no study investigated implicit learning in epileptic children. implicit learning is not only underlying motor skills acquisition, but also social and cognitive ones. because acquisition of new skills is optimal during childhood, the study of implicit learning mechanism in children is of major importance. the present study will be the first to explore implicit learning mechanisms in children with epilepsy. implicit learning mechanisms can be preserved or altered.


Eligibility criteria:
inclusion criteria: * for patient group only: children with epilepsy * for control group only: children without neurological, psychiatric or developmental impairments * for both groups: parent or tutors agreement * for both groups: affiliated to french social security exclusion criteria: * neurological impairments unrelated to epilepsy * psychiatric impairments unrelated to epilepsy * developmental impairments unrelated to epilepsy

Keywords: epilepsy, children, implicit learning