Kornimate/medical-research-clean huggingface dataset:
assessment of clinical performance and costs of the endeavor resolute stent "in real life" in spain.

Conditions: Coronary Artery Disease

Summary: the redes registry is set up to document the overall clinical performance and costs of the endeavor resolute coronary stent in a "real life" subject population of 450 patients that require a stent in spain. primary objectives are the overall cost for patients during initial hospitalization and at 1-year follow-up, as well as the mace rate at 30 days, 6 months and 12 months post procedure.


Eligibility criteria:
inclusion criteria: * subject is \>18 years old * subject has agreed to participate in the study by signing the "patient informed consent" and/or has authorized the collection and disclosure of their personal health information by signing the "patient data collection form". * there is an indication for a drug-eluting stent and a clinical decision to use endeavor resolute in all the lesions found. * subject is able and willing to co-operate and to comply with the study protocol and undergo follow-up requirements. exclusion criteria: * subject is a childbearing or breastfeeding female. * subject has a known hypersensitivity or allergy to acetylsalicylic acid, heparin, clopidogrel, ticlopidine, drugs such as zotarolimus, rapamycin, tacrolimus, sirolimus or other similar drugs, or any other analog or derivative drug, cobalt, chrome, nickel, molybdenum or contrast media. * subject has a contraindication to anticoagulants and/or antiplatelets. * subject's lesion might prevent proper balloon inflation during angioplasty. * primary or rescue angioplasty. * subject has one or more drug-eluting stents other than endeavor resolute in other lesions. * intention for elective treatment with other drug-eluting stent other than endeavor resolute. * current medical condition is associated with a life expectancy ≤ 12 months. * subject is participating in another investigational drug or device study and has not completed the follow-up required for that study at least 30 days prior to signing the consent form in this study. subject can only be enrolled once in this study. * subject has a medical condition preventing follow-up as established in the protocol or limiting participation in this study. * subject cannot guarantee follow-up.
the effect of mk0633 in patients with chronic asthma (0633-007)

Conditions: Asthma

Summary: a clinical study to evaluate the efficacy and safety of mk0633 in adult patients with chronic asthma.


Eligibility criteria:
inclusion criteria: * documented clinical history of symptoms of chronic asthma, including dyspnea, wheezing, chest tightness, cough, and/or sputum production * males and females 18-70 years of age exclusion criteria: * history of kidney or chronic liver disease * recent history of heart problems within the past 3 months * evidence of another clinically significant, active lung disorder such as bronchiectasis or copd
development of a youth healthy living program with underserved adolescents at rochester alternative learning center

Conditions: Childhood Obesity

Summary: approximately one third of the children and adolescents in the united states are either overweight or obese. childhood obesity disproportionately affects specific racial and ethnic groups and households with low socioeconomic status and low parental education. the alternative learning center (alc) within rochester school district 535 provides viable educational options for students who are experiencing difficulty in regular educational systems. a greater proportion of students at alc are minorities, qualify for free and reduced lunch and receive special education services. these children are likely to have unique barriers to physical activity and healthy eating. specific aims: aim 1: examine the association between bmi and ethnic/ socioeconomic variables and behaviors related to physical activity and eating in alc students. aim 2: develop an age and culturally appropriate on-site program that promotes healthy lifestyle.

investigators will assess the relationship between bmi and ethnicity, socioeconomic variables and behaviors related to nutrition and physical activity among 200 alc students. investigators will also conduct 6 gender stratified (3 boys, 3 girls) focus groups with students (n=24), up to 3 focus groups with their parents (n=24) and one focus group with staff and volunteers in order to understand perceived barriers towards healthy weight/nutrition/physical activity. investigators will then utilize this information to co-develop a healthy living program at alc. investigators will finally test the feasibility of the program they develop over a period of 3 months in alc students. study findings will inform further research to test the efficacy and validity of the program developed at alc in a subsequent school based trial with the future goal of obtaining funding for cluster randomized controlled trials among other schools in the region.

Eligibility criteria:
inclusion criteria: * rochester alternative learning center students ages 12 years to 20 years * parents/guardians of alc students * alc staff. exclusion criteria: * inability to assent or consent to participate in the study.

Keywords: obesity prevention cbpr high risk youth school health
technology-based intervention to promote heart health after cardiac rehab (mobile4heart)

Conditions: Ischemic Heart Disease; Unstable Angina; Systolic Heart Failure; Cardiovascular Diseases

Summary: the purpose of this study is to determine whether using a mobile app increases adherence to a heart healthy prescription after discharge from a cardiac rehab program.

ongoing maintenance of physical activity after cardiac rehab is an important part of preventing secondary cardiac events in patients with ischemic heart disease. our central hypothesis is that monitoring and promotion of health-related behaviors by increasing patient-provider communication through a mobile device after discharge from cardiac rehab increased adherence to a heart healthy prescription over time. participants will be randomly assigned to use a mobile app or serve as the control group. all participants will have an activity tracker to track their activity for two months.

Eligibility criteria:
inclusion criteria: * at least 18 years of age * history of cardiovascular disease that qualified patient for cardiac rehab (i.e. ischemic heart disease, history of unstable angina, systolic heart failure with ejection fraction at 35% or less, and class ii to iv symptoms, coronary artery bypass graft surgery, valve replacement) * own a smartphone or tablet exclusion criteria: * cognitive impairment * lack of english proficiency/literacy * clinical conditions including: unstable arrhythmias, aortic stenosis, thrombophlebitis, dissecting aneurysm, symptomatic anemia, active infection, uncontrolled hypertension (resting diastolic \> 100 mmhg, systolic \> 180 mmhg), decompensated heart failure nyha class 3-4, current unstable angina, 2nd or 3rd degree heart block, or uncontrolled high grade exercise-induced ventricular ectopy
training effects in colonoscopy

Conditions: Adenoma Detection Rate

Summary: colon cancer is the second most common cause of death among cancer-related deaths in germany. precancerous lesions such as adenomas can be detected efficiently by colonoscopy. to provide high quality in colonoscopy several quality parameters have been postulated in the past. the adenoma detection rate (adr) is one of those parameters. empirical data suggest that a detection rate of 20% should be demanded. detection rates are influenced by a multitude of circumstances such as bowel cleanness. the facts that detection rates vary between colonoscopists suggests that leaning effects may also play a role. it is not known how adr and other quality parameters evolve while trainees improve their skills in colonoscopy. the investigators postulate that a learning curve exists. the investigators therefore plan to evaluate chronologically the findings of trainee colonoscopists. a particular performance in detecting adenomas shall be calculated in relation to the amount of examinations performed.


Eligibility criteria:
inclusion criteria: * colonoscopy performed at the technical university munich, germany exclusion criteria: * colonoscopy performed for the purpose of polypectomy

Keywords: adenoma detection rate, colonoscopy, trainee, learning curve
platelet rich plasma in women with urinary incontinence

Conditions: Urinary Incontinence; Stress Urinary Incontinence

Summary: stress urinary incontinence (sui) is defined as involuntary loss of urine on effort or physical exertion or on sneezing or coughing. platelet-rich plasma (prp) is an autologous solution of human plasma containing various growth factors witch enhance regeneration and healing process. the aim of this study is to evaluate the efficacy and safety of prp in the treatment of the female sui.


Eligibility criteria:
inclusion criteria: * adult women with stress urinary incontinence exclusion criteria: * pregnancy, * history of active malignant pathology, * mental disorders making them unable to give consent, * undiagnosed abnormal uterine bleeding, * genitourinary fistula, * anti-incontinence surgery, * pelvic organ prolapse stage \> 2 according to pop-q system

Keywords: incontinence urinary incontinence stress urinary incontinence platelet rich plasma prp, outpatient treatment nonsurgical treatment
mdr - biomet cannulated screws

Conditions: Fractures, Bone; Fracture Multiple

Summary: the objective of this retrospective enrollment/prospective follow up study is to collect data confirming safety, performance, and clinical benefits of the biomet cannulated bone screw system (implants and instrumentation) when used according to the approved indications for use (ifu).

the objective of this retrospective enrollment/prospective follow up study is to collect data confirming safety, performance, and clinical benefits of the biomet cannulated bone screw system (implants and instrumentation) when used according to the approved indications for use (ifu). safety will be established by recording the incidence and frequency of complications and adverse events. relationship of the events to either implant or instrumentation should be specified. performance and clinical benefits will be assessed by analyzing fracture healing/fusion and the overall pain and functional performance of subjects who received the biomet cannulated bone screws by recording survey questions. zimmer biomet defines the expected performance rate for cannulated screws for long and small bone fractures to be a union rate of at least 81% at 8-12 months.

Eligibility criteria:
inclusion criteria: * patient must be 18 years of age or older. all patients operated on for the following indications: * group 1, small cannulated screws (4.0mm and smaller diameter) are intended for use in: 1. fixation of small bones, including those in the foot, patella, ankle, wrist and elbow. 2. arthrodesis of the foot, wrist and elbow. 3. small and long bone osteotomies. 4. fracture fixation of small bones, small bone fragments and long bones. * group 2, large cannulated screws (5mm and larger in diameter) are intended for use in: 1. fixation of fractures in long bones and long bone fragments. 2. long bone osteotomies (femur, tibia, foot, ankle, olecranon). 3. arthrodesis and fracture fixation of the foot and ankle, such as jones fractures of the fifth metatarsal, and calcaneal fractures. * group 3, large cannulated screws (6.5mm and larger in diameter) are intended for use in: 1. slipped capital femoral epiphysis 2. pediatric femoral neck fractures 3. tibial plateau fractures 4. si joint disruptions 5. intercondylar femur fractures 6. subtalar arthrodesis 7. fixation of pelvis and iliosacral joint * patients must have the ability and willingness to follow instructions, including control of weight and activity levels. * patient must have a good nutritional state. exclusion criteria: * infections. * patient conditions including blood supply limitations, insufficient quantity or quality of bone. * patients with mental or neurologic conditions who are unwilling or incapable fo following postoperative care instructions. * foreign body sensitivity where material sensitivity is suspected or unknown, testing is to be completed prior to implantation of the device. * patient is a prisoner. * patient is a current alcohol or drug abuser. * patient is known to be pregnant or breastfeeding. * patient has a psychiatric illness or cognitive deficit that will not allow for proper informed consent.
comparison of different protocols of fluid therapy in severe preeclamptic patients under spinal anesthesia

Conditions: Hypotension Drug-Induced

Summary: to compare the effect of two different protocol of fluid therapy in sever preeclamptic patients under spinal anesthesia : hemodynamic and kidney function .


Eligibility criteria:
inclusion criteria: * more than 36 weeks gestation * singleton pregnant women planned for elective caesarian section exclusion criteria: * patient refusal. * psychiatric disorders. * parturient \<36 weeks gestation, twins, abnormal cardiotocography (ctg) tracing. * absolute contraindications for spinal anesthesia (patients refusal, raised intracranial pressure, hypovolemic states, abnormal coagulopathy).
using different doses of active vitamin d combined with neutral phosphate in children with x-linked hypophosphatemia

Conditions: X-linked Hypophosphatemia

Summary: x-linked hypophosphatemia (xlh) is the most common form of heritable rickets. current treatments include active vitamin d metabolites (e.g. calcitriol) and phosphate salts. there is no consistent weight-based dosing of calcitriol and phosphate now. the primary objective of this study is to establish the efficacy of different dose of calcitriol combined with neutral phosphate in children with xlh.


Eligibility criteria:
inclusion criteria: * male or female, aged 1-12 years, inclusive * diagnosis of xlh by clinical features: serum phosphorus level \< 2.5 mg/dl; alp?; rss total score ≥2; bowed legs; short stature; family history with appropriate x-linked inheritance * meet at least one of the following: confirmed phosphate regulating gene with homology to endopeptidases located on the x chromosome (phex) mutation in the participant, or serum fgf23 level \>30 pg/ml (kainos assay) * willing to participate the study, and provide an informed consent * able to complete all aspects of study and adhere to the visit schedule exclusion criteria: * use of growth hormone within 12 months before first visit * height \>50 percentile for age and sex specific data * presence of nephrocalcinosis or nephrolithiasis * serum intact parathyroid hormone level\>170 pg/ml * plan to receive orthopaedic surgery in 12 months * poor compliance * use of gonadotropin-releasing hormone therapy right now * use of aluminium hydroxide, steroid, acetazolamide or thiazide drugs within 7 days before first visit * not be fit to participant in the study, by the judgement of investigators
detection and quant of differences in hodgkin lymphoma and diffuse large b-cell lymphoma using positron emission tomography/computed tomography (pet/ct)

Conditions: Lymphoma

Summary: rationale: imaging procedures, such as positron emission tomography or computed tomography, may help in detecting differences between hodgkin lymphoma or diffuse large b-cell lymphoma cancer cells. purpose: this clinical trial is studying positron emission tomogaphy and computed tomography in determining differences in hodgkin lymphoma and diffuse large b-cell lymphoma.

objectives: i. assess the feasibility of detection and quantification of differences in the temporal and spatial distribution of fdg uptake between lesions of hl and dlbcl. outline: patients undergo fludeoxyglucose f18 (fdg) positron emission tomography/computed tomography scans 60 and 180 minutes after fdg administration. after completion of study, patients are followed for 24 hours.

Eligibility criteria:
inclusion criteria: * subjects with a pathologically-proven diagnosis of classic hl or dlbcl with measurable disease by any imaging technique or physical examination. exclusion criteria: * pregnant or nursing, * uncontrolled diabetes mellitus, * active infection, * inability to give informed consent or to comply with all study procedures, * subjects may be excluded at the discretion of the principal investigator or study team members.
investigating the effectiveness of telepsychiatry for treating major depression in a chinese american nursing home

Conditions: Major Depressive Disorder

Summary: the current use of telepsychiatry, or psychiatric care using videoconferencing, is very limited. the present study investigates the use of this method with a depressed chinese american population in a nursing home. it is believed that this population can benefit from telepsychiatric treatment when used in collaboration with the primary care they receive in the nursing home.

individuals at the south cove manor nursing home will be referred to this study if they are experiencing depression. after meeting with the principal investigator (a psychiatrist), he will collaborate with the primary care physician and the nursing home staff to establish a treatment plan for the patient. videoconferencing will be used by the p.i. for regular psychiatric visits with the patient as well as meetings with the nursing home staff to coordinate care for the patient. after collaboration between the two groups, treatment suggestions will be given to the patient's primary care physician (pcp) to implement in the primary care setting. the patient's symptomology, mood, satisfaction of life and side effects of medication will be recorded regularly to measure the effects of treatment for analysis.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of major depressive disorder * patient at south cove manor nursing home * referred by nursing staff for psychiatric consultation exclusion criteria: * not competent to participate in psychiatric interviews

Keywords: major depressive disorder telepsychiatry chinese american nursing home
dash diet intervention for systemic hypertension in adolescents

Conditions: Hypertension; Food Insecurity

Summary: parallel randomized clinical trial comparing dash produce home delivery to routine care for the management of elevated blood pressure and hypertension in adolescents.

parallel randomized clinical trial comparing dash produce home delivery to routine care for the management of elevated blood pressure and hypertension in adolescents.

Eligibility criteria:
inclusion criteria: age 12 to 17 years of age at baseline visit elevated blood pressure or hypertension - exclusion criteria: inability to eat by mouth secondary hypertension
smartphone-based neurobehavioral assessments as a diagnostic aid in autism

Conditions: Autism Spectrum Disorder

Summary: retrospective case-control study to assess the diagnostic accuracy in autism spectrum disorder (asd) of a new smartphone-based platform designed to conduct neurometric evaluations by measuring facial and behavioural reflexes.

this is a retrospective multi-centre case-control study to measure sensorimotor anomalies linked to autism spectrum disorder (asd) to assess the diagnostic accuracy of smartphone-based neurobehavioral evaluations. the primary objective of the study is to evaluate diagnostic accuracy of the smartphone-based assessments compared to a formal clinical diagnosis using machine learning algorithms. neurobehavioral testing will be performed using blinklab, a smartphone-based platform. the tests include general measurement of spontaneous and stimulus-evoked postural, head, facial, and vocal responses along with specific neurometric tests, including the acoustically evoked eyelid startle reflex (asr), and tests that involve the modulation of the asr, including prepulse inhibition (ppi) and habituation (hab). children required to participate in two consecutive 15-minute tests. during the experiment, the children will watch an audio-normalized movie while the trials containing the auditory stimuli will be delivered via headphones. for each trial, computer vision algorithms will be used to track and record the position of the participant's facial landmarks over time. the study will compare responses in children with asd who received a formal dsm-5 based diagnosis prior to study inclusion and neurotypical children that had no formal psychiatric diagnoses.

Eligibility criteria:
inclusion criteria: * male or female individuals between the ages of 3 - 12 years old at the time of consent. * caregiver must be able to read, understand and sign the informed consent form (icf). * normal or corrected-to-normal vision with visual acuity sufficient to watch short videos. * hearing adequate to hear the auditory stimuli delivered via headphones. exclusion criteria: * participants under 3 or over 12 years old. * severe hearing or visual impairment. * participants using medication that affects the nervous system (classified as atc n0 medication, https://www.whocc.no).
the mechanisms of diameter changes in retinal vessels during hypoxia

Conditions: Retinal Hypoxia

Summary: the primary objective is to study if a stimulation of nitric oxide and/or prostaglandin affect the diameter changes of retinal vessels during hypoxia. diameter changes are studied using the dynamic vessel analyzer.


Eligibility criteria:
inclusion criteria: * age between \>19 and \<61 years * no known systemic or ocular diseases exclusion criteria: * cardio-vascular disease * lung disease * epilepsy * previous ocular disease * previous treatment with medications influencing the intraocular pressure or the metabolism of nitric oxide or prostaglandins * daily intake of medicine except contraceptive pills * pregnancy or breastfeeding * known allergy against any of the drugs used in the interventions