Kornimate/medical-research-clean huggingface dataset:
effects of ahes on dra in postpartum women

Conditions: Diastasis Recti

Summary: this study is aimed to determine the effects of abdominal hypopressive exercises on ird, lumbopelvic pain, body image and abdominal muscle function in postpartum women.

postnatal women wish to resume abdominal exercises shortly after delivery to improve trunk function and restore the pre-pregnant state of the body. diastasis recti is a common occurrence in the postpartum period which is associated with both physical impairments and body image concerns. despite the high prevalence, treatment options are still being explored to identify the best approach to resolve it. exercise is a conservative method to reduce ird and improve the associated symptoms and quality of life of postpartum females. most of the previous studies have used either digital nylon calipers or digital palpation methods for the outcome assessment of dra which has important implications. fewer studies have used the gold standard us diagnosis. despite various studies being conducted on the effect of exercise on dra, the results are still nonconclusive with a deficiency of a standardized protocol. multifaceted and clinically meaningful assessments have been proposed to be investigated by the previous literature.

Eligibility criteria:
inclusion criteria: * 12 weeks to 36 weeks postpartum * both vaginal delivery and c-section * lumbopelvic pain (nprs \>4) * diagnosis of dra by calliper: 3 cm below the umbilicus: \>22 mm, at the umbilicus: \>20 mm, 3 cm above the umbilicus: \>14 mm * primiparous females exclusion criteria: * any conditions affecting the ability to perform exercise or activity of daily living. * previous spinal or abdominal surgery, and neuromuscular diseases. * severe dra \>5cm with the herniation or requiring surgical repair. * lbp associated with disc herniation, spondylolysis, and degenerative changes of the spine

Keywords: diastasis recti diastasis recti and weakness of linea alba low back pain
pre-emptive treatments in lupus nephritis patients with serological reactivation

Conditions: Lupus Nephritis

Summary: the optimal management of asymptomatic serological reactivation (asr) in lupus nephritis (ln) patients remained undefined. this project aims to investigate the impact of pre-emptive treatment on disease relapse in ln patients who experienced asr.

ln patients who presented with asr \[defined as 1) increase in anti-dsdna \>100 iu/ml , with or without drop in serum complement; or 2) increase in anti-dsdna to higher than the normal range and \>2 times of the preceding value, with or without drop in serum complement; and 3) absence of renal or systemic manifestations of sle) will be randomized to receive pre-emptive increase in immunosuppression or had their current immunosuppressive therapies unchanged. patients will be followed at 4-, 12-, 24-wk and then every 12 weeks up to 24 months to monitor for renal or extra-renal relapses. bloods and urine will be collected for measurement of renal and serological parameters, and also b cell signatures. primary outcomes: renal flare (denoted as proteinuria \>1g/d; presence of urinary rbc \>30 hpf/rbc casts, or increase in scr \>15% and positive anti-dsdna) secondary outcomes: * safety \& tolerability of pre-emptive increase of immunosuppressive treatments * extra-renal flares * renal function at 24 months * changes in serological parameters

Eligibility criteria:
inclusion criteria: * patients with biopsy-proven lupus nephritis who experienced an episode of asymptomatic serological flare (asf) as defined by: 1. increase in anti-dsdna to \>100 iu/ml, with or without drop in serum complement levels or 2. increase in anti-dsdna to higher than the normal range and more than two times of the preceding value, with or without drop in serum complement levels and 3. absence of renal or systemic manifestation of sle. exclusion criteria: 1. patients who cannot provide informed consent. 2. patients whom the clinicians opined to have excessively high risk of infection or malignancy. 3. patients who are pregnant or lactating.
acute effects of juice consumption with biofunctional compounds and probiotics on glucose metabolism

Conditions: Potential Abnormality of Glucose Tolerance; Appetite Disorders

Summary: this study investigated the short-term effects of fruit juice enriched with vitamin d3 or n-3 pufa or probiotics and the combination of the three ingredients on glucose metabolism.

this study aimed to 1. determine the glycemic index and glycemic load of mixed fruit juice (pomegranate, grape, apple, and orange) enriched with vitamin d3 or n-3 pufa or probiotics, and the combination of the three bio-functional ingredients, compared to regular mixed fruit juice and the reference food (d-glucose), and 2.examine the short-term effects of the five mixed fruit juices on postprandial blood glucose and salivary insulin responses, blood pressure, and subjective appetite, in healthy adults.

Eligibility criteria:
inclusion criteria: * healthy * non-smoking * non-diabetic men and women * body mass index between 18.5 and 25 kg.m2 exclusion criteria: * severe chronic disease (e.g. cardiovascular diseases, diabetes mellitus, kidney or liver conditions, endocrine conditions) * gastrointestinal disorders * pregnancy * lactation * competitive sports * alcohol abuse * drug dependency

Keywords: blood glucose insulin glycemic index glycemic load juices probiotics vitamin d3 n-3 fatty acids
a comparison between stn-dbs and gpi-dbs in meige syndrome evaluated by flexible electrodes

Conditions: Meige Syndrome

Summary: deep-brain stimulation (dbs) is an effective treatment for patients with meige syndrome. the globus pallidus interna (gpi) and the subthalamic nucleus (stn) are both accepted targets for this treatment. researchers designed this study to compare the 12-month outcomes for patients who undergo bilateral stimulation of the gpi or stn.

deep-brain stimulation (dbs) is an effective treatment for patients with meige syndrome. the globus pallidus interna (gpi) and the subthalamic nucleus (stn) are accepted targets for this treatment. researchers are willing to compared12-month outcomes for patients who had undergone bilateral stimulation of the gpi or stn. forty-two asian patients with primary meige syndrome who underwent gpi or stn neurostimulation were recruited between nov. 2023 and nov. 2025 at the department of neurosurgery, qilu hospital. the primary outcome was the change in motor function, including the burke-fahn-marsden dystonia rating scale movement (bfmdrs-m) and disability subscale (bfmdrs-d) at 3 days before dbs (baseline) surgery and 1, 3, 6, and 12 months after surgery. secondary outcomes included health-related quality of life, sleep quality status, depression severity, and anxiety severity at 3 days before and 12 months after dbs surgery.

Eligibility criteria:
inclusion criteria: 1. primary meige syndrome was diagnosed by an experienced neurologist. 2. all patients had received systematic and regular treatment for at least 1 year before surgery, including oral drugs and local injection of botulinum toxin a, but the efficacy was not apparent, as the ability to engage with daily life and the quality of life of the patients significantly decreased. 3. tere were no other serious systemic diseases, such as severe organic heart disease, severe lung, liver and kidney dysfunction, and coagulation dysfunction. 4. tere was no history of neurological diseases other than meige syndrome, such as parkinson's disease or severe cognitive dysfunction. 5. tere were no serious psychiatric disorders, such as schizophrenia. 6. preoperative head magnetic resonance imaging (mri) examinations were normal. patients of missing follow-up and incomplete clinical data were excluded from the cases. exclusion criteria: 1. unilateral facial spas and blepharospasm. 2. patients with severe disease such as coronary heart disease, stroke.

Keywords: dbs stn vs gpi
pilates to treat low back pain

Conditions: Pain; Quality of Life

Summary: this is a randomized controlled trial, with blinded assessor to evaluate the effectiveness of pilates to treat low back pain. hypothesis - the pilates group will have best results than the control group (usual medicament treatment).

background: low back pain (lbp) is a common problem among adults. approximately 70-85% of the adult population experiences this painful complaint at some point in their lives, making lbp the second most common reason for a visit to a clinician. despite the frequency of this diagnosis, conventional treatment does not always provide patients the desired results of reduced pain and return of normal function. for these patients, alternative modalities are available to assist in the control of pain. these options include chiropractic care, physical therapy, massage therapy, and modalities that fall under the auspices of complementary and alternative medicine, such as acupuncture. unfortunately, clinical trials evaluating the efficacy of a variety of interventions for chronic non-specific low back pain indicate limited effectiveness for most commonly applied interventions and approaches. objectives: to evaluate the effectiveness of a mat and studio pilates program on pain, function, quality of life and nhai consumption for chronic non-specific low back pain patients. methods: eligible patient include: chronic non-specific low back pain; age between 18 and 65 years; pain ranging from 4 to 8 in a numerical pain scale. patients with previous surgery, other causes of low back pain, fibromyalgia, regular physical activity (three or more times per week for at least three months); labor lawsuit and body mass index more than 30. sixty patients were randomized to the experimental group (eg) or control group (cg). patients in eg participated in 90 days of mat and studio pilates program twice a week (50 minutes per class) and the cg remained with their usual medicament treatment and were included in a waiting list for physiotherapy. assessment for pain (vas), function (roland morris questionnaire), quality of life (sf-36) and nhai consumption were done at baseline, after 45 days (t45), after 90 days (t90 - end of the program), after 90 days (t180 - follow up) by a blinded assessor.

Eligibility criteria:
inclusion criteria: * non specific mechanical low back pain * visual analogue scale for pain ranging from 4 to 7 exclusion criteria: * previous back surgery * spinal tumor * spinal fracture * pregnancy * fibromyalgia * inflammatory or infectious spinal diseases * litigant patients

Keywords: pilates exercise treatment low back pain pain function
ang1005 in breast cancer patients with recurrent brain metastases

Conditions: Breast Cancer; Brain Metastases

Summary: this is a phase 2 study to see if an investigational drug, ang1005, can shrink tumor cells in breast cancer patients with recurrent brain metastases.


Eligibility criteria:
inclusion criteria: 1. ≥ 18 years old 2. breast cancer 3. recurrent brain metastases from breast cancer 4. at least one radiologically-confirmed and measurable metastatic brain lesion ( ≥ 0.5 cm) 5. neurologically stable 6. karnofsky performance status (kps) score ≥ 70 7. adequate hematology and serum chemistry laboratory test results 8. expected survival of ≥ 3 months exclusion criteria: 1. prior treatment with ang1005/grn1005 2. evidence of symptomatic intracranial hemorrhage 3. pregnancy or lactation 4. inadequate bone marrow reserve 5. any evidence of severe or uncontrolled diseases 6. patients with the presence of an infection including abscess or fistulae, or known infection with hepatitis b or c or hiv 7. history of interstitial lung disease or evidence of clinically significant interstitial lung disease 8. severe cardiac conduction disturbance 9. central nervous system (cns) disease requiring immediate neurosurgery intervention 10. known severe hypersensitivity or allergy to paclitaxel or any of its components

Keywords: ang1005 grn1005 low-density lipoprotein receptor-related protein (lrp-1) targeted therapy breast cancer brain metastases brain tumor blood-brain barrier trastuzumab herceptin paclitaxel taxol breast cancer with brain metastases triple negative triple negative breast cancer (tnbc) herceptin 2 (her2)-positive her2-negative metastatic brain tumors
a study to evaluate the conformis itotal identity knee replacement system

Conditions: Osteoarthritis, Knee

Summary: this is a prospective multicenter study located in the united states. subjects will be implanted with an itotal identity knee replacement system and followed for 10 years post implantation.


Eligibility criteria:
inclusion criteria: * clinical condition included in the approved indications for use for the itotal identity cr krs * osteoarthritis, as confirmed by the investigator's assessment of disease status at screening visit that warrants a tkr procedure. disease status is assessed by clinical and radiographic assessment. * willingness to participate in the clinical study, to give informed consent, and to attend all follow-up visits * \> 18 years of age with complete development of musculoskeletal structures exclusion criteria: * simultaneous bilateral procedure required * bmi \> 40 * active malignancy (defined as a history of any invasive malignancy - except nonmelanoma skin cancer), unless subject has been treated with curative intent and there have been no clinical signs or symptoms of the malignancy for at least 5 years * poorly controlled diabetes (defined as hba1c \>7 or investigator discretion) * neuromuscular conditions which prevent subject from participating in study activities * active local or systemic infection which precludes tkr procedure * immunocompromised in the opinion of the investigator * medically diagnosed fibromyalgia or similar conditions that might impact the subject's ability to differentiate source of pain * rheumatoid arthritis or other forms of inflammatory joint disease * loss of bone or musculature, osteonecrosis, neuromuscular or vascular compromise in the area of the joint to be operated on, to an extent that the procedure is unjustified * diagnosed with or receiving treatment for osteoporosis that is likely to confound results in the opinion of the investigator * other physical disability affecting the hips, spine, or contralateral knee that is likely to confound results in the opinion of the investigator * severe instability due to advanced loss of osteochondral structure * prior arthroplasty of the affected knee, including high tibial osteotomy (hto) * compromised pcl or collateral ligament * severe fixed valgus or varus deformity of \>15º * extensor lag \> 15º * fixed flexion contracture ≥ 15º * unwilling or unable to comply with study requirements * participation in another clinical study which would confound results * allergy to any of the implant materials * pregnant or planning to become pregnant prior to study tkr procedure (in case of pregnancy after study tkr procedure, eligibility to continue with the protocol will be reviewed)
comparison of esp block and m-tapa block efficiency in postoperative analgesia management in nephrectomy cases

Conditions: Pain, Postoperative

Summary: relieving postoperative nephrectomy pain requires multimodal approaches. peripheral blocks such as esp block and m-tapa block and multimodal analgesics reduce side effects by reducing the use of other analgesics. this study aimed to compare the effectiveness of erector spinae plane block (esp block) and modified thoracoabdominal nerve blocking with perichondrial approach (m-tapa block) in postoperative analgesia management in nephrectomy cases.

relieving postoperative nephrectomy pain requires multimodal approaches. the most commonly used in the treatment of pain are nonsteroidal anti-inflammatory drugs (nsaids), opioids, and infiltration of local anesthetics. due to the side effects of nsaids and opioids, the application of regional analgesia techniques can reduce complications while providing better analgesia quality. peripheral blocks such as esp block and m-tapa block and multimodal analgesics reduce side effects by reducing the use of other analgesics. pain is considered one of the most important factors affecting the quality of healing. postoperative pain delays the postanesthesia care unit, hospital stay, early ambulation, increases resource utilization, and negatively affects patient satisfaction. if postoperative analgesia is provided, all these negativities will be eliminated. this study aimed to compare the effectiveness of erector spinae plane block (esp block) and modified thoracoabdominal nerve blocking with perichondrial approach (m-tapa block) in postoperative analgesia management in nephrectomy cases.

Eligibility criteria:
inclusion criteria: * all patients aged 18 and over with asa1-2 who underwent elective nephrectomy exclusion criteria: * asa ≥3 * body mass index\>35 kg/ m² * infection in the block area * coagulation disorder, * known allergy to local anesthetics * pregnant * patient with neuropathy * patient without cooperation * patient who refuses to participate in the study * patients under 18 years of age

Keywords: nerve block pain management postoperative period postoperative complications regional anesthesia pain
the validity of retinal blood flow measurements during hyperoxia in humans using fourier domain color doppler optical coherence tomography (cdoct)

Conditions: Healthy

Summary: noninvasive monitoring of blood flow in retinal circulation may elucidate the progression and treatment of ocular disorders, including diabetic retinopathy, age-related macular degeneration and glaucoma. laser doppler velocimetry (ldv), a noninvasive optical method combined with vessel size determination has been used extensively as a valuable research tool to examine blood flow dynamics in the human retina. however, no information on the velocity profile within the vessel is available. ophthalmic color doppler optical coherence tomography (cdoct) provides laser doppler information in addition to conventional optical coherence tomography, allowing the observation of blood flow dynamics simultaneously to imaging retinal structure. we have recently demonstrated the feasibility of fourier domain cdoct to assess velocity profiles in human retinal vessels in vivo. in the present study the validity of fourier domain cdoct for retinal blood flow measurements will be tested at baseline and during hyperoxia-induced vasoconstriction in humans by comparison with retinal blood flow measurements using a commercially available ldv system and the zeiss retinal vessel analyzer (rva)


Eligibility criteria:
inclusion criteria: * men aged between 19 and 35 years, nonsmokers * normal findings in the medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant * normal ophthalmic findings, ametropia \< 3 dpt exclusion criteria: * regular use of medication, abuse of alcoholic beverages, participation in a clinical trial in the 3 weeks preceding the study * treatment in the previous 3 weeks with any drug * symptoms of a clinically relevant illness in the 3 weeks before the first study day * history or presence of gastrointestinal, liver or kidney disease, or other conditions known to interfere with distribution, metabolism or excretion of study drugs * blood donation during the previous 3 weeks * ametropia equal or over 3 dpt

Keywords: regional blood flow color doppler optical coherence tomography cdoct retinal blood flow hyperoxia vasoconstriction laser doppler velocimetry retinal vessel analyzer
diagnosis and evaluation of patients needing third molar (wisdom tooth) extraction and patients with chronic facial pain

Conditions: Facial Pain; Temporomandibular Joint Disorder

Summary: this study provides a mechanism for evaluating patients for possible participation in nidcr clinical research studies. nidcr studies involve three major areas-pain, neurosensory mechanisms, and pain-relieving drugs-all of which have specific requirements and patient characteristics. no treatment is offered under this protocol; it is intended to facilitate patient recruitment into nidcr studies. patients with unusual or unknown conditions that have or have not been diagnosed may be eligible for this screening study. specific medical criteria for enrollment vary with the particular protocol for which the individual is being screened. medical and dental histories will be obtained and participants will have a dental examination. diagnostic procedures will be done in accord with standard medical and dental practice and may include x-rays, blood tests, and routine urinalysis, as appropriate. participants found eligible for an active study may enroll in that study. those who are not eligible for a current study may be re-evaluated for future studies within a year if they wish. after 1 year, participants for whom no appropriate studies are identified will be referred back to their primary doctor or referring physician or dentist.

this protocol is designed to screen individuals with either third molars ("wisdom teeth") in need of removal, or with chronic orofacial pain as potential research subjects. each individual will be thoroughly evaluated during the screening process, including past medical history and an appropriate physical examination. other routine diagnostic procedures and tests may also be completed in order to help determine a subject's eligibility. these tests and procedures are of minimal risks and will be described in more detail in section iii: "study procedures". once the screening process is completed and eligibility determined, the subjects will be informed of their options to participate in one or more of the current nidcr research studies. if no appropriate protocol is identified, recommendations for other treatment options may be given to the individual, their primary doctor, or referring physician/dentist.

Eligibility criteria:
inclusion criteria varies with the particular protocol for which a patient is being screened. subjects with unusual or unknown conditions that require the establishment of a diagnosis, or those with an established diagnosis may be selected. subjects source for this study will be from referrals by medical and dental practitioners in the private sector, clinics, hospitals, dental-medical institutions, commissioned officers dental clinic, and the occupational medical services at the national institutes of health.

Keywords: screening protocol temporomandibular disorders oral surgery chronic orofacial pain
aging, nitrate, endothelial function and muscle oxygenation

Conditions: Aging; Hypertension; Dyslipidemia; Abdominal Obesity

Summary: aging has been associated with reduced bioavailability of nitric oxide (no) and endothelial dysfunction. beetroot consumption, a nitrate-rich food, has been associated with increased no bioconversion, which may promote beneficial effects on vascular health. the present study evaluated the effects of a beetroot-based nutritional gel (bg) on vascular function, arterial stiffness and blood pressure in the elderly at cardiometabolic risk. twenty elderly individuals were submitted to bg and nitrate-depleted gel (pla) interventions. brachial flow-mediated dilation (fmd), blood flow velocity (bfv), peak wave velocity (pwvβ), augmentation index (ai), stiffness parameter (β), pressure-strain elasticity modulus (ep), arterial compliance (ac), muscle oxygenation and function were measured 90 min after interventions. urinary nitrate, nitrite, systolic blood pressure (sbp), diastolic blood pressure (dbp) and heart rate (hr) were measured at baseline, 90 min and 150 min after interventions.


Eligibility criteria:
inclusion criteria: * elderly participants (≥ 65 years) * taking between 1 and 3 anti-hypertensive medications for high blood pressure; * elevated triglycerides ≥ 150 mg/dl; * reduced hdl-cholesterol \< 50 mg/dl for women and \< 40 mg/dl for men; * elevated waist circumference by population definition (male: \> 102 cm and female: \> 88 cm). exclusion criteria: elevated fasting glucose (≥ 100 mg/dl), smoking, beetroot allergy, unwillingness to avoid beetroot products during the entire study, other chronic diseases (diabetes, liver disease, etc.), or acutely ill.

Keywords: aging beetroot dietary nitrate functional food vascular function