Kornimate/medical-research-clean huggingface dataset:
a study evaluating potential screening tools for detecting parkinson disease

Conditions: Parkinson Disease

Summary: this study is designed as a prospective cohort study to test the strategy of combining two biomarkers of parkinsonism, olfaction and brain imaging with a radioactively labeled drug, \[123i\]β-cit , in a population of first-degree relatives of pd patients as a tool to establish an 'at risk' parkinson disease cohort without motor symptoms of pd. first-degree relatives of pd will be recruited through pd research sites and national foundations to participate in this study. in addition, first degree relatives of pd patients will be recruited directly through advertising.

first-degree relatives that agree to participate (n=3,000) will be asked to complete a 40-item olfactory identification test provided by mail. 300 subjects (225 with decreased odor identification and 75 with normal olfaction) will be invited to undergo dat imaging at the institute for neurodegenerative disorders in new haven, ct. there will also be additional clinical follow-up at participant's clinical (local) site. the primary outcome measure for the study will be the mean striatal uptake of \[123i\]b-cit in first-degree relatives with a loss of odor identification, which will be compared to an established healthy control database (age 40-70; n=50). 300 relatives will be followed longitudinally with clinical evaluations and a second imaging study completed after two years. comparing the first and second scans in this subset of subjects will allow us to evaluate the rate of progressive loss in dopamine transporter density during this pre-symptomatic period.

Eligibility criteria:
at risk - inclusion criteria: * subject must have a first-degree relative with pd, based on their report * subject must not carry a diagnosis of pd or other neurodegenerative disorder. * subject must be either at least 50 yrs old or within 10 yrs of the age of onset of their affected relative * subject must have no other known reason for abnormal olfaction (e.g. nasal trauma, sinus infection, sinus surgery) * subject must not be pregnant if participating in the imaging portion of this study non-first degree relative - inclusion criteria: * subject must not carry a diagnosis of pd or other neurodegenerative disorders * subject must have no other known reason for abnormal olfaction (e.g. nasal trauma, sinus infection, sinus surgery) * subject must not be pregnant or be an actively nursing mother if participating in the imaging portion of this study. exclusion criteria: * diagnosis of pd or other neurodegenerative disorder * other known reason for abnormal olfaction (e.g. nasal trauma, sinus infection, sinus surgery) * pregnancy, if participating in the imaging portion of this study

Keywords: parkinson disease spect imaging
neuro-prävention im rahmen des interventionsprojektes invade-2 (follow-up studie)

Conditions: Stroke; Dementia

Summary: "silent" strokes are more frequent than clinical apparent strokes and can be detected noninvasively by mri-investigations of the brain. persons with silent strokes have a considerably increased risk for clinical apparent strokes as well as for the development of dementia. intention of the study is the detection of silent strokes and microbleedings by standardized cranial mri in 1000 participants (500 high-risk and 500 low-risk persons for cerebrovascular accidents) after a standardized neurological and neuropsychological examination. results will be the base of early detection and early preventive strategies of cerebrovascular accidents in high-risk persons. in the course of a systematic follow-up examination without mri the same 1000 patients (500 high-risk and 500 low-risk persons for cerebrovascular accidents) will be reinvited to the sites. in addition to the standardized neurological and neuropsychological examinations a surrogate parameter of nephropathy, microalbumin, will be examined as this parameter could be helpful in forecasting cerebral microangiopathy. the clinical investigation will be expanded by several tests in order to assess symptoms of cerebral microangiopathy.


Eligibility criteria:
inclusion criteria: * signed informed consent for npv-2 * ongoing participation in invade-2 * completed participation in neuroprävention study (npv-1) exclusion criteria: * not completed neuroprävention study (drop-out) * disagreement of notification of incidental findings * lack of capacity to consent of study participant * lack of willingness to cooperate of study participant

Keywords: systematic prevention, stroke, vascular dementia, silent strokes, cerebral microangiopathy.
effects of exercise training on cardiovascular health in middle-aged women

Conditions: Menopause; Cardiac Function Impaired; Cardiovascular Diseases; Blood Platelet Disorders; Metabolic Diseases

Summary: the hypothesis of the present study is that physical training can oppose detrimental changes in cardiovascular and metabolic health associated with estrogen loss after menopause.


Eligibility criteria:
inclusion criteria: * premenopausal (45-53 years) or postmenopausal 50-57 years * bmi\> 18.5 and \<30 * sedentary (no regular physical activity the last 2 years) * plasma measurements * premenopausal: estradiol\> 0.20 nmol/l, follicle stimulating hormone \ 2.5 nmol/l * postmenopausal: estradiol \ 22 iu/l and progesterone 0.3-2.5 nmol/l exclusion criteria: * smoking * excessive alcohol intake * regular medication including hormone replacement treatment * chronic disease

Keywords: premenopausal postmenopausal cardiovascular exercise training vascular function cardiac function cardiac morphology health
efficacy and cost analysis of plastic stent compare to metallic stent in hilar cholangiocarcinoma

Conditions: Hilar Cholangiocarcinoma

Summary: the purpose of this study is to compare the adequacy of unilateral endoscopic biliary drainage using metallic stent with plastic stent in unresectable, complex, hilar, cholangiocarcinoma and cost analysis.

there are two types of biliary stents: 1) the plastic stent made from polyethylene or polytetrafluoroethylene; and, 2) the metal stent braided in the form of a tubular mesh from surgical-grade stainless steel alloy and designed to expand to a maximum diameter of 10 mm. the main drawback of the plastic stent is the relatively high occlusion rate, but its advantage is the lower cost. the use of a metal stent for hilar tumor has many theoretical advantages: 1) the flexible open-mesh design should allow drainage of secondary duct branches; and, 2) its larger diameter may provide better drainage and longer patency (\~3-9 months). whether one type of stent is superior in terms of adequacy of drainage or cost-effectiveness remains undefined. therefore, we would conduct this study to assess the efficacy of drainage of endoscopically-inserted, unilateral, plastic stents vs. metallic stents in unresectable, complex, hilar cholangiocarcinoma patients.

Eligibility criteria:
inclusion criteria: * unresectable complex hilar cholangiocarcinoma which diagnosis and staging based on computed tomography(ct) or magnetic resonance cholangiopancreatography (mrcp) exclusion criteria: * patients with asa 4 or 5 * patients with liver failure. * patients unable to comply with follow-up

Keywords: biliary stent plastic stent metallic stent complex hilar cholangiocarcinoma (bismuth type ii,iii,iv)
text messaging to improve adherence to clinic visits and reduce early resumption of sexual intercourse after male circumcision

Conditions: HIV Infections; Acquired Immunodeficiency Syndrome; Circumcision, Male; Patient Compliance; Cellular Phone

Summary: male circumcision (mc) reduces, by more than half, the risk of hiv-1 acquisition. who and unaids recommend that "male circumcision should be recognized as an efficacious intervention for hiv prevention especially in countries and regions with heterosexual hiv epidemics and low male circumcision prevalence." as a result, programs have been introduced and scaled up for voluntary medical male circumcision. kenya leads with the largest expansion of services. early resumption of sexual intercourse after mc may have deleterious effects, including higher rates of post-operative surgical complications, and higher hiv acquisition among females in couples that resume sexual activity before certified wound healing. in the context of rapid scale-up of mc, adherence to post-operative clinic appointments allows clinicians to assess wound healing and to deliver risk reduction counseling. abstinence from sexual intercourse before complete wound healing would reduce the rate of post-operative adverse events and minimize the risk of hiv transmission from hiv-infected men to their uninfected female partners. to the investigators knowledge, the effect of reminders delivered via text messaging to promote adherence to clinic visits and abstinence after mc has not been investigated. the investigators propose a randomized controlled trial in which men who will have undergone voluntary medical male circumcision at selected sites in kisumu will be randomized to receive either the intervention (context-sensitive text messages after circumcision) or the control condition (usual care). this study seeks to determine (a) the effect of regular text messages sent to men after circumcision on attendance of the scheduled 7-day post-operative clinic visit versus usual care; (b) the proportion of men who resume sexual activity before 42 days post-procedure after receiving regular text messages versus usual care within the 42 days post-circumcision; and (c) to identify potential predictors of failure to attend the scheduled 7-day post-operative visit and early resumption of sexual intercourse.


Eligibility criteria:
inclusion criteria: * male * 18 years or older * have undergone circumcision on the day they are screened for the study * currently own a mobile phone with text-messaging capability, and * have the mobile phone in their possession at the time of enrollment * able and willing to respond to a questionnaire administered via a phone call exclusion criteria: * prior participation in a study on male circumcision * currently participating in other ongoing research studies * any medical condition or situation exists such that study participation would not be in the man's best interest, as determined by the investigator

Keywords: hiv infections acquired immunodeficiency syndrome circumcision, male coitus patient compliance cellular phone
the electrophysiological signature of the mental fatigue-induced impairment in endurance performance

Conditions: Mental Fatigue; Electroencephalography

Summary: the purpose of this project is to provide further insights into the neurophysiology behind the mf-induced impairment in endurance performance. the aim is to perform a randomized controlled trial in which we partly replicate studies of marcora et al. (2009) and bigliassi et al. (2017), while extensively monitoring brain activity during the entire protocol (i.e. both cognitive and physical tasks) by using eeg.


Eligibility criteria:
inclusion criteria: * healthy (no neurological or cardiovascular disorders) * male or female * no medication * non-smoker * between 18 and 35 years old * recreational athlete population (performance level 2 or 3 for men according to de pauw et al. (2013) and performance level 2 or 3 for woman according to decroix et al. (2016) exclusion criteria: * injuries over the last 6 months * suffering from any cardiovascular condition * use of medication * suffering from other health conditions at the time of testing * use of caffeine or alcohol 24 hours prior to each trial * heavy efforts 24 hours prior to each trial
pro for fighting ft in ovarian cancer

Conditions: Ovarian Cancer

Summary: non-profit, multicenter, prospective, observational study. this study aims to evaluate whether the articulated treatment algorithm that is now possible for oc patients does produce tangible changes of financial distress over the time and whether the determinants of financial distress change their relative weight over the time.

proffit questionnaire is an italian instrument for evaluating ft in cancer patients in the italian healthcare context. it includes 16 total items, 7 measuring ft (defining the proffit financial score) and 9 measuring possible determinants of ft.the primary aim of the study is to compare proffit financial score (items 1-7 measuring the financial distress) across different lines of treatment for oc patients undergoing anticancer medical treatment. primary comparison will be based on proffit questionnaire fulfilled at baseline, before starting each line of treatment. in addition, among secondary aims of this study, we aim to verify whether ft is associated with quality of life response (items 29-30 of the eortc qlq-c30 questionnaire and items 55-56 of the eortc qlq-ov28 questionnaire), with patient-self reporting toxicity of treatments (selected symptoms of the pro-ctcae library response), and with overall survival.

Eligibility criteria:
inclusion criteria: * written informed consent provided; * women ≥18 years; * histologically or citologically confirmed diagnosis of epithelial ovarian, fallopian tube or peritoneal cancer stage ic-iv according to figo staging system; * patients who are close to begin any type of medical treatment against ovarian cancer. exclusion criteria: * major cognitive dysfunction or psychiatric disorders; * patients with epithelial ovarian, fallopian tube or peritoneal cancer candidate exclusively to follow-up; * patients who have received more than 4 previous lines of medical treatment (maintenance treatments do not represent a line).

Keywords: ovarian cancer financial toxicity quality of life proffit questionnaire pro-ctcae
comparison of narrow band imaging with or without magnifying colonoscopy

Conditions: Intestinal Polyps

Summary: the aim of this study is to evaluate the usefulness of magnifying colonoscopy with narrow band imaging.

the accuracy of histologic prediction for the colorectal polyps with the use of narrow band imaging is evaluated between the test group with magnifying colonoscopy and the control group without magnifying colonoscopy.

Eligibility criteria:
inclusion criteria: * subjects with colorectal polyps which are in need of emr exclusion criteria: * pregnancy, ibd, colorectal cancer, etc.
the immediate effects of kinesio-taping on scapular muscle endurance and strength in asymptomatic subjects

Conditions: Asymptomatic Subjects

Summary: the purpose of this study was to investigate the immediate effects of kinesio-taping (kt) on scapular muscle endurance and strength and compared to placebo kinesio-taping in asymptomatic subjects.

thirty-nine asymptomatic subjects (20 females and 19 males, mean age 20.46±1.09 years, mean bmi 21.99±3.02 kg/m2) were included in this study. subjects were randomly allocated to kt (with the muscle facilitation technique) and placebo-kt (without any technique and tension). scapular isometric muscle endurance was measured with a scapular muscle endurance test. the strength of the upper, middle, and lower trapezius, and serratus anterior was assessed using a hand-held digital dynamometer. data were analyzed with 2x2 \[groups (kt and placebo-kt) x time (pre- and post-intervention)\] mixed-model anova.

Eligibility criteria:
inclusion criteria: * an age range of 18 to 25 years, * the ability to participate voluntarily. exclusion criteria: * shoulder injuries in the last year, previous shoulder surgery, shoulder dislocation, and having performed upper-body exercises within the 24 hours before each evaluation session. - diagnosed with cardiovascular or neurological disease

Keywords: kinesio-taping scapula endurance muscle strength fatigue
the safety and feasibility of laparoscopic-assisted gastrectomy for advanced gastric cancer after neoadjuvant chemotherapy

Conditions: Stomach Neoplasms

Summary: the purpose of this study is to explore the safety, feasibility, long-term and oncologicaloutcomes of laparoscopic-assisted gastrectomy for advanced gastric cancer after neoadjuvant chemotherapy.

a prospective single-arm study designed to further evaluate laparoscopic-assisted gastrectomy for advanced gastric cancer after neoadjuvant chemotherapy will be performed, to evaluate the safety, feasibility, long-term and oncological outcomes. the evaluation parameters are perioperative mobility and mortality, perioperative clinical efficacy, postoperative life quality, immune function and 3-year survival and recurrence rates.

Eligibility criteria:
inclusion criteria: * age from 18 to 75 years * primary gastric adenocarcinoma (papillary, tubular, mucinous, signet ring cell, or poorly differentiated) confirmed pathologically by endoscopic biopsy * ct2-4an+m0 at preoperative evaluation according to the american joint committee on cancer (ajcc) cancer staging manual seventh edition * no distant metastasis is observed. and the spleen, pancreas or other adjacent organs are not involved by the tumor. * performance status of 0 or 1 on eastern cooperative oncology group scale (ecog) * american society of anesthesiology score (asa) class i, ii, or iii * written informed consent exclusion criteria: * women during pregnancy or breast-feeding * severe mental disorder * history of previous upper abdominal surgery (except laparoscopic cholecystectomy, previous gastrectomy, endoscopic mucosal resection or endoscopic submucosal dissection) * history of previous gastrectomy, endoscopic mucosal resection or endoscopic submucosal dissection * history of other malignant disease within past five years * history of unstable angina or myocardial infarction within past six months * history of cerebrovascular accident within past six months * history of continuous systematic administration of corticosteroids within one month * requirement of simultaneous surgery for other disease * emergency surgery due to complication (bleeding, obstruction or perforation) caused by gastric cancer * fev1\<50% of predicted values

Keywords: stomach neoplasms laparoscopy advanced gastric cancer neoadjuvant chemotherapy
pet / ct imaging and safety in patients with lymphoma treated with cd19 car-t cells

Conditions: Lymphoma

Summary: the proliferation and distribution of cd19 car-t cells in lymphoma patients are investigated 68ga-nota-rp25 by pet / ct imaging.

the purpose of this study is to monitor the proliferation and distribution of cd19 car-t cells in lymphoma patients by using a novel specific pet tracer 68ga-nota-rp25 for monitoring the proliferation of car-t cells.

Eligibility criteria:
inclusion criteria: * 1. the subjects voluntarily signed the informed consent form and were able to complete the test according to the protocol requirements; 2. over 18 years old, male or female; 3. diagnosed as lymphoma and intended to receive cd19 car-t treatment; 4. ecog score is 0-1; the estimated survival time shall not be less than 3 months; exclusion criteria: * 1. participate in other clinical trials other than car-t treatment at the same time or within 28 days. if participating in a non intervention clinical trial, it can be included in this study; 2. patients with a history of allergy; 3. patients who cannot tolerant pet / ct imaging； 4. patients who are using anticoagulant drugs or need to use anticoagulant drugs during the study;
alitretinoin in the treatment of chronic hand eczema

Conditions: Eczema

Summary: the purpose of the study is to investigate the safety and efficacy of alitretinoin in chronic hand eczema that is refractory to topical corticosteroids.

chronic hand eczema is a frequent and distressing disease. the course of the disease is of chronic-relapsing nature. in a phase iii study alitretinoin was clinically effective for patients with severe chronic hand eczema refractory to topical treatment. this study investigates the safety and efficacy of alitretinoin who previously have participated in a clinical trial involving alitretinoin.

Eligibility criteria:
inclusion criteria: * previous participation in therapeutic trials involving chronic hand eczema * relapse of chronic hand eczema, defined as 75% of the baseline initial total lesion symptom score exclusion criteria: * patients whose disease is adequately controlled by standard non-medicated skin care and topical corticosteroid therapy

Keywords: chronic hand eczema chronic hand dermatitis patients with chronic hand eczema, who are refractory to topical corticosteroids
pressure support ventilation during cf exacerbations

Conditions: Cystic Fibrosis

Summary: chest physiotherapy is recognized as a mainstay of cystic fibrosis therapy, and is particularly important during treatment of pulmonary exacerbations. for some patients, especially those with moderate to severe compromise of lung function, this therapy may impose a high demand in the work of breathing and energy expenditure. the goal of this study is to evaluate the effectiveness of adding pressure support ventilation (psv) during chest physiotherapy sessions in patients with cystic fibrosis with moderate to severe lung function compromise being treated for a pulmonary exacerbation.

the proposed study will be conducted over three years. cystic fibrosis patients with moderate to severe pulmonary disease who are experiencing an acute exacerbation that requires hospitalization will be admitted to the gcrc. subject participation in the study will be for the first 10 days of hospitalization. subjects will be randomized into one of two treatment groups: usual care or usual care plus non-invasive pressure support ventilation (psv).

Eligibility criteria:
cystic fibrosis subjects with pulmonary exacerbation
stimulate brain and reduce knee pain due to degeneration

Conditions: Knee Osteoarthritis

Summary: osteoarthritis (oa) knee is chronic, slowly progressive, degenerative disease of joint which affects articular cartilage and accompanied by pain, swelling and loss of function . oa is often considered as the serious joint disease as it has negative impact on quality of life among elderly population, it is the major cause for the reduced mobility. at cental level, due to imbalance in endogenous pain modulation there is reduce capacity of brain to inhibit the pain. therefore, dysregulation in the central modulation of pain further leads to maladaptive changes in the brain structure. transcranial direct current stimulation is a non-invasive method to modulate the brain structure by using a week direct current applied through the scalp in painless way. multi-session for prolonged time can induce neuroplastic changes in the brain. the aim of the study is to demonstrate the effectiveness of tdcs in reducing the pain among patients with chronic knee oa and to modulate the plastic changes in brain structure. a total of 80 patients with koa will be recruited by the convenience sampling to participate in this two group pretest-posttest, double blinded randomized clinical study. after the demographics, recruited 80 patients with koa will be randomly divided into two groups, transcranial direct current stimulation (tdcs) group and conventional physiotherapy (cpt) group with by block randomization. patients with koa in tdcs group will be provided with active tdcs and conventional physiotherapy and cpt group will receive structured exercises protocol. pre-post changes in the outcome measures will be documented at baseline and end of 8-week post intervention. each session will last for approximately 30 minutes duration.


Eligibility criteria:
inclusion criteria: * patients diagnosed with clinical knee oa according to the diagnostic criteria of acr were included in the study exclusion criteria: * unwillingness to participate in the study * recent history (within the last 3 months) of physical therapy to the same joint * recent history (within the last 3 months) of intra-articular procedure (injection and/or lavage) to the knee * history of knee surgery/fracture * acute synovitis/arthritis including the infectious conditions * taking pain relief medications * any metal implantation near site of stimulation

Keywords: transcranial direct current stimulation pain knee osteoarthritis exercise therapy