Kornimate/medical-research-clean huggingface dataset:
interstitial cystitis and urinary ph

Conditions: Interstitial Cystitis

Summary: this is a pilot study to assess the correlation between urinary ph and interstitial cystitis (ic) pain, with emphasis placed on exploring the type and severity of pain.

subjects who agree to participate in the study will meet with a research team member who will review the study with them, obtain informed consent sign the hippa form, and provide study materials (void diary for urine quantification and recording of ic symptoms, ph strips to dip urine, "hat" to measure urine). medical charts will be reviewed to determined how interstitial cystitis was diagnosed, medications, medical/surgical history, and demographics such as weight, height, bmi, race, age, marital status, education, insurance, tobacco or alcohol use. subjects will need to dip ph paper into the urine and specific gravity reagent strip, and, by color comparison between the strips and the corresponding scales, determine and record urine ph and specific gravity. they will need to fill out the corresponding section in the voiding diary that is a survey to type and severity or pain as well as other symptoms of ic. the research team member will teach the subject how to measure the volume of their urine and how to measure and record specific gravity and ph. when not practical to record the volume of the urine (when patients are at work or away from home) they will still be asked to record ph, specific gravity and experienced symptoms. subjects will be asked to perform the above described protocol with each episode of micturition for 3 days. after enrollment, subjects will complete the o'leary-sant pain (symptom and problem index) questionnaire, if subjects have a combined score greater than or equal to 12 they are considered to have problematic or symptomatic ic. the voiding diary that include ph and specific gravity measurement measurements, times, volume, and survey of symptoms will be returned 1-2 weeks following completion of 3 day void diary for a face-to-face meeting with a research team member. attempts will be made to have those meetings coincide with a clinical visit to minimize study burden to the subject(e.g. - at the time of cystoscopy or follow-up visit. )

Eligibility criteria:
inclusion criteria: * women aged 18-70, with diagnosed interstitial cystitis (ic) and bladder pain present during week preceding enrollment. exclusion criteria: * subjects who are pregnant. subjects with current uti or are unwilling/unable to provide consent.
peripherally inserted central catheter (picc) thrombosis: reverse taper versus non-tapered catheters

Conditions: Venous Thrombosis

Summary: the purpose of this study is to compare two different marketed picc (peripherally inserted central catheter) designs. clotting rates, procedural bleeding and ease of catheter insertion will be compared. it is hypothesized that the non-tapered design has a lower clotting rate and is easier to place than the tapered design. bleeding rates are expected to be about the same.


Eligibility criteria:
inclusion criteria: * all inpatients, age 18 to 90, in need of de novo central venous access with a double lumen catheter indication of \> 2 weeks * informed consent and hipaa consent forms discussed and signed by patient or their authorized representative exclusion criteria: * skin related problems around the insertion site (infection, phlebitis, scars) * history of mastectomy/axillary dissection on insertion side * coagulopathy with an inr of \> 2.0 * thrombocytopenia with platelets \< 25,000 ul * renal insufficiency with a creatinine of \> 3.0 mg/dl * documented current upper extremity or central venous thrombosis * hypercoagulable states (protein c or s deficiency, at-iii deficiency, lupus anticoagulant) * catheters needed for therapy within less than an hour (emergent placement not allowing sufficient time for proper research consent and randomization) * patient has already been enrolled in this research study * life expectancy less than 1 month

Keywords: inpatients requiring dl picc access medications blood
a relative bioavailability study measuring the extent and rate of absorption of different tablet formulations of azd1656 in type 2 diabetes mellitus (t2dm) patients

Conditions: Type 2 Diabetes Mellitus; High Blood Sugar

Summary: the purpose of this study is to assess the relative bioavailability by measuring the extent and rate of absorption of different tablet formulations of azd1656 in t2dm patients.


Eligibility criteria:
inclusion criteria: * provision of signed and dated, written informed consent prior to any study specific procedures. * males or females of non-childbearing potential (post-menopausal, and/or have undergone hysterectomy and/or bilateral oophorectomy or salpingectomy/ tubal ligation) aged ≥18 years. females will be defined as post-menopausal if last menstruation period was \>1 year ago and serum follicle stimulating hormone (fsh) is within the post-menopausal range, or if age \>50 years and with last menstruation period \>2 years ago. * a confirmed clinical diagnosis of t2dm for at least 1 year, treated with metformin as a single treatment or in combination with one other oral anti-diabetic (ie, dppiv inhibitor or su) for at least 2 months prior to screening. doses of anti-diabetic treatment should have been stable for at least 1 month prior to screening. * treatment with at least 1000mg of metformin for 2 months and being stable on the metformin therapy for 1 month * hb a1c \>6.5% (international standard) at enrolment. * body mass index (bmi) between ≥19 and ≤42 kg/m2. exclusion criteria: * clinically significant illness or clinically relevant trauma, as judged by the investigator, within 2 weeks prior to the first administration of azd1656 * participation in another clinical study during the 30 days prior to screening or intake of another investigational drug within 30 days (or at least 5 x t1/2 of the drug) prior to the first administration of azd1656. * history of, or ongoing, ischemic heart disease or heart failure. stroke, transitory ischemic attack, or symptomatic peripheral arterial disease within the last 6 months. * clinically significant abnormalities in ecg, clinical chemistry, hematology or urinalysis results. * positive test for hepatitis b surface antigen (hbsag) or antibodies to human immunodeficiency virus (hiv) or hepatitis c virus.

Keywords: phase i bioavailability type 2 diabetes mellitus diabetic treatment metformin high blood sugar
the effect of oxygen application with double nasal cannula on respiratory complications

Conditions: Gastric Disease; Gastric Distress

Summary: to compare desaturation and respiratory complications by applying oxygen therapy with double nasal cannula to patients who are planned to undergo gastrointestinal endoscopy.

two groups of patients scheduled for gastrointestinal endoscopy will be compared in terms of desaturation and respiratory complications by applying 15 litres of oxygen therapy to the first group and 30 litres to the second group with double nasal cannula.

Eligibility criteria:
inclusion criteria: 18-65 years old patients who will have endoscopy and or colonoscopy exclusion criteria: * chronic obstructive pulmonary disease having low saturation lung cancer

Keywords: desaturation oxygen therapy sedoanalgesia
china rural hypertension control project

Conditions: Hypertension

Summary: china rural hypertension control (crhc) project is a cluster randomized trial that will test the effectiveness of a village doctor-led multifaceted intensive blood pressure intervention on hypertension control in 18 months (phase 1), cardiovascular disease risk in 36 months (phase 2), and all-cause dementia in 48 months (phase 3) among patients with hypertension in rural china.

the overall objective of the crhc project is to develop an effective, adoptable, and sustainable implementation strategy to achieve more intensive blood pressure (bp) control among rural residents in china. moreover, this effectiveness-implementation trial will test the effectiveness of a lower bp target (\<130/80 mmhg) on cardiovascular disease (cvd) and all-cause dementia. specifically, we will test the effectiveness of a village doctor-led multifaceted intervention, compared with usual care, on bp control, cvd, and dementia among rural residents with hypertension in china. this cluster randomized trial is conducted in 326 villages from three provinces in mainland china. a total of 163 villages was randomly assigned to a village doctor-led multifaceted intervention and 163 villages to usual care, stratified by provinces, counties, and townships. a total of 33,995 individuals aged ≥40 years with uncontrolled hypertension were recruited into the study. the village doctor-led multifaceted intervention is designed to overcome barriers at the healthcare system, provider, patient, and community levels. study participants are followed every 6 months for bp, cvd, and other study outcomes. the primary outcome is bp control (\<130/80 mm hg) at 18 months in phase 1, cvd events over 36 months in phase 2, and all-cause dementia at 48 months in phase 3.

Eligibility criteria:
eligibility criteria for study villages: * the village has a regular village doctor who is willing to participate in the hypertension control project * the village does not plan to merge with other villages within 3 years * the village is at least 2 kilometers away from other participating villages * the village participates in the china new rural cooperative medical scheme eligibility criteria of study participants: * men or women aged ≥40 years * mean untreated systolic bp ≥140 mm hg and/or diastolic bp ≥90 mm hg or mean treated systolic bp ≥130 mm hg and/or diastolic bp ≥80 mm hg for individuals without a history of clinical cvd; or mean treated/untreated systolic bp ≥130 mm hg and/or diastolic bp ≥80 mm hg for individuals with a history of clinical coronary heart disease, heart failure, stroke, diabetes, or chronic kidney disease * have lived in a participating village for at least 6 months * no intention to migrate within next 3 years * taking part in the new rural cooperative medical scheme * not pregnant or planning to become pregnant * no malignant tumors and life expectancy ≥3 years * willing to participate and able to sign informed consent

Keywords: hypertension cardiovascular disease dementia china protocol-based treatment stroke
efficacy and safety of anti-covid-19 antibody sa58 nasal spray to prevent infection in high-risk populations

Conditions: COVID-19

Summary: this is an open, blank controlled clinical trial to evaluate the efficacy and safety of sa58 nasal spray in the prevention covid-19 infection among health care workers at high risk of sars-cov-2 infection.

this is an open, blank controlled clinical trial to evaluate the efficacy and safety of sa58 nasal spray in the prevention covid-19 infection among health care workers at high risk of sars-cov-2 infection.the investigational drug was manufactured by sinovac life sciences co. , ltd.a total of 7000 medical personnel will be involved in this study: 3500 will use sa58 nasal spray in the drug group, and 3500 not use sa58 nasal spray in the blank control group. the medication is self-administered intranasally 1\~2 times per day with an interval of 6 hours for about 30 days.

Eligibility criteria:
inclusion criteria: * medical staff working in the designated covid-19 hospitals and fangcang shelter hospitals (alternate care sites) of covid-19 cases in hohhot; * subjects were 18 years of age and older and in good health; * subjects volunteered to use covid-19 neutralizing antibody nasal spray. exclusion criteria: * previous history of severe allergies or sensitivity to inhaled allergens; * women were pregnant or breastfeeding; * subjects were unable to cooperate with nasal spray inhalation; * other conditions for which medication was not appropriate.
optimization of management for sporadic bilateral renal cell carcinoma

Conditions: Kidney Cancer

Summary: sporadic bilateral renal cell carcinoma (brcc) is a rare situation of rcc. the treatment for brcc is controversial and there is a lack of authoritative guidelines about the management of brcc. the goal of this cohort study is to identify prognostic factors, construct predictive nomograms, and optimize management for sporadic brcc patients. the main questions it aims to answer are: what are the factors influencing the prognosis of brcc patients? what's the appropriate treatment for brcc patients? researchers will analysis the prognostic factors and compare the prognosis of brcc patients receiving different treatments.

sporadic bilateral renal cell carcinoma (brcc) is a rare situation of rcc. the treatment for brcc is controversial and there is a lack of authoritative guidelines about the management of brcc. this cohort study aims to identify prognostic factors, construct predictive nomograms, and optimize surgical treatment for sporadic brcc patients. the main questions it aims to answer are: what are the factors influencing the prognosis of brcc patients? what's the appropriate treatment for brcc patients? in this retrospective population-based cohort study, patients diagnosed with sporadic brcc between 2000 and 2020 were identified from the surveillance, epidemiology, and end results (seer) database. researchers will analysis the prognostic factors and compare the prognosis of brcc patients receiving different treatments.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years. * clinical diagnosis of localized brcc (m0) from 2000 to 2020. * active follow-up. * complete clinicopathological information. exclusion criteria: * diagnosed by autopsy or death certificate only. * tending to suffer from hereditary rcc, including those complicating with pancreatic neuroendocrine tumor (pnet) or hemangioblastoma. * unavailable key information.

Keywords: bilateral renal cell carcinoma surgery partial nephrectomy local tumor destruction nomogram
physical activity, hypertension, diabetes, and coronary heart disease

Conditions: Cardiovascular Diseases; Heart Diseases; Diabetes Mellitus; Coronary Disease; Hypertension; Diabetes Mellitus, Non-insulin Dependent

Summary: to study the influences of physical activity on the incidence of hypertension, non-insulin-dependent diabetes (niddm), and coronary heart disease (chd), taking into account the influences of other life-style elements such as body size, cigarette habit, alcohol consumption habits, and parental history of disease on these same chronic diseases.

background: epidemiologic investigations of the influence of physical activity on the incidence of specific chronic diseases encounter problems of confounding or interaction with eating behavior, tobacco use, other social habits, and a host of personal characteristics. these influences of life styles on chronic diseases are not mutually exclusive, nor do they operate independently. rather, they blend, amplifying or diminishing the effects of one another. design narrative: the study used data collected since 1960 as part of the college alumni health study -- a cohort of 50,000 former students who attended harvard college, 1916-1950, or the university of pennsylvania, 1931-1940, and who reported by questionnaire on their health habits and health status in post-college years through 1988. over 17,000 harvard alumni have been followed from 1962 through 1988 for both non-fatal and fatal chronic diseases. these predictor (risk factors) and outcome (specific diseases) data were analyzed to test the hypothesis that different kinds and amounts (frequencies, intensities, durations, and constancies) of physical activity affect differently the incidence rates of hypertension, niddm, and chd. continuities and changes in specific life styles and chronic diseases have been measured continually through return-mail questionnaires in 1962, 1966, 1972, i977, and 1988. cause-specific mortality has been monitored continuously over this span of time, 1962-1988. using the data, the investigators computed relative and attributable risks of developing hypertension, niddm, and chd that related to alumni patterns of physical activity, body size, alcohol consumption, cigarette use, and other personal characteristics and ways-of-living. in this discrete population, they searched for the relative importance of physical activity and other potential predictors in influencing the occurrence of these hypertensive-metabolic-atherosclerotic diseases.

Eligibility criteria:
no eligibility criteria
pdt as an adjunct to srp in the management of chronic periodontitis

Conditions: Chronic Periodontitis

Summary: the present study aims to evaluate photodynamic therapy (pdt) using zinc oxide as a photosensitizer as an adjunct to scaling and root planing (srp) in the management of chronic periodontitis.

following full mouth srp, each quadrant will be randomly assigned by simple randomization using a computer generated randomization technique into one of the following four treatment modalities. group 1 (control) - application of placebo gel followed by sham pdt (directing the light cure device without turning on the light beam). group 2 -application of zinc oxide gel followed by sham pdt. group 3 - application of placebo gel followed by pdt. group 4 - application of zinc oxide gel followed by pdt. the procedure mentioned for each group will be performed on all periodontal pockets in the assigned quadrant at baseline, end of 1 week and 1 month from the first session. clinical parameters and microbial profile will be recorded at baseline (before commencement of periodontal treatment), end of 1 month and end of 3 months following periodontal treatment. zinc oxide gel/placebo gel will be placed into the periodontal pockets using a blunt cannula ensuring that starting from the bottom, it completely fills the periodontal pockets. the gel will be retained in the pocket for 5 minutes. the perio tip will be attached to the hand piece of the light cure unit (wavelength: 420-480nm. light power: 1200mw/cm2 in continuous mode) and light will be activated for 60 seconds. following this, the pockets will be irrigated with normal saline solution (0.9%sodium chloride).

Eligibility criteria:
inclusion criteria: * patients of both genders diagnosed with chronic periodontitis in the age group of 30 to 50 years with good systemic health. * presence of a minimum of 20 teeth and at least one site with probing pocket depth (ppd) of 4-7 mm and clinical attachment level (cal) of 2 mm or greater, in each of the four quadrants. exclusion criteria: * patients who have undergone periodontal therapy during the previous 6 months of commencement of the study. * subjects on antibiotics or immunosuppressant medication 6 months prior to the study. * chronic smokers, alcoholics, smokeless tobacco users. * subjects with acute illnesses/acute intraoral lesions. * pregnant women and lactating mothers. * medically compromised subjects.
enhanced dpp-glb to promote weight loss among nonresponders in a community-based lifestyle intervention.

Conditions: Diabetes

Summary: this study seeks to establish the efficacy of identifying weight loss nonresponders early in a diabetes prevention program (dpp) intervention in 20 community settings (primarily churches and community centers) and providing them with individual-level, enhanced treatment through telephone contacts and access to additional resources. additionally, potential mediators and moderators of the relationship between intervention status and weight loss response at 6 months in both nonresponders and responders will be examined and a cost-effectiveness analysis to evaluate the cost of the intervention will be conducted. this study addresses key gaps in the literature about the weight loss effects of identifying nonresponders early and characterizing individuals who need more intense personalized strategies. the investigators hypothesize that changes between baseline and 3 months will be more pronounced among the nonresponders in the intervention group compared to the nonresponders in the active control group.


Eligibility criteria:
inclusion criteria: * self-described as black * non-diabetic * body mass index (bmi) equal to or greater than 25 * cdc diabetes risk assessment greater than or equal to 5 or diabetes pre-diagnosis or history of gestational diabetes * live within driving distance of participating church/site exclusion criteria: * diagnosed type 1 or 2 diabetes * pregnant or planning to become pregnant during study period * contraindications to moderate physical activity * serious medical condition that contradicts weight loss * not black or african american

Keywords: prevention weight loss community personalized telephone resources lifestyle intervention racial ethnic minorities / african american faith based obesity non-responders adults cancer
randomized trial of accelerated partial breast irradiation

Conditions: Breast Neoplasms; Neoplasm Recurrence, Local

Summary: this study is to compare radiation toxicity of accelerated partial breast irradiation (abpi) with whole breast irradiation (wbi) in low-risk breast cancer.

this study is a single-center phase ii randomized clinical trial to enroll low-risk breast cancer treat with breast-conserving surgery. all eligible patients are randomized to receive either abpi (40gy/10fx/2wks) or wbi(43.5gy/15fx/3wks). intensity modulated radiation therapy (imrt) technique is used. grade 2 or more acute and late toxicities are prospectively evaluated and compared.

Eligibility criteria:
inclusion criteria: * life expectation: \> 5 years * enrollment date no more than 12 weeks after breast-conserving surgery or no more than 8 weeks after adjuvant chemotherapy * histologically confirmed diagnosis of invasive ductal carcinoma (grade 1-2), or mucinous carcinoma, or papillary carcinoma, or tubular carcinoma, or medullary carcinoma: primary tumor ≤ 3.0cm in maximum diameter and pn0; or histologically confirmed dcis: primary tumor ≤ 2.5cm in maximum diameter, low-medium grade * unifocal tumour (confirmed by diagnostic mri) * no lymphovascular invasion * er positive (defined as medium-strongly nuclear staining in \>1% of the cancer cells) * negative radial resection margins of \>= 2 mm * surgical clips placed in the tumor bed * written informed consent. exclusion criteria: * stage ⅱ-ⅲ * multifocal tumors * histologically confirmed diagnosis of invasive ductal carcinoma (grade 3), - - - invasive micropapillary carcinoma, carcinoma of lobular in situ, invasive - - - lobular carcinoma * paget's disease of the nipple * underwent oncoplastic surgery of ipsilateral breast * underwent neoadjuvant chemotherapy or hormonal therapy * previous or simultaneous contralateral breast cancer * undergone ipsilateral chest wall radiotherapy * active collagen vascular disease.
vibrotactile stimulation for upper-extremity stroke rehabilitation

Conditions: Stroke

Summary: the goal of this clinical trial is to investigate upper-extremity vibrotactile stimulation with wearables in stroke patients. the main questions it aims to answer are: are the wearables well-tolerated by patients? does the vibrotactile stimulation help regain arm function? participants will wear vibrotactile stimulation gloves and shirts for 5 hours daily during their stay at the rehabilitation unit, in addition to conventional therapy. researchers will compare the treatment group (vibrotactile stimulation wearables) with a control group (conventional therapy only) to see the effects of the vibrotactile stimulation.


Eligibility criteria:
inclusion criteria: * inpatients at rehabilitation units * unilateral left or right sided ischemic stroke within the previous 2 weeks * have upper-extremity fugl-meyer scores between 6 and 58 * have at least 20 degrees of active shoulder elevation and elbow flexion * expected to stay 1-3 weeks in the rehabilitation unit exclusion criteria: * under anti-spasticity therapy * patients that are dependent on pacemakers * patients that have defibrillators * have lymphedema or av fistula for dialysis on an arm