Kornimate/medical-research-clean huggingface dataset:
the morphology and parameter estimation of cranial ultrasound spectrum based on cerebral artery

Conditions: Intracranial Pressure Increase

Summary: 1. observe the changes of tcd/tccd spectrum shape before and after lumbar puncture in patients with severe neurological disease. 2. discuss the tcd/tccd spectrum shape and parameters of cerebral arteries and neurocritical patients correlation of intracranial pressure.

after entering the icu, the subjects who meet the standards will undergo a full-body physical examination and basic vital signs assessment and monitoring, which mainly include specialized examinations of the nervous system, multimodal brain function testing, respiratory system monitoring and management, hemodynamic monitoring, and apacheⅱ score, gcs score, and perform routine general circulation, breathing management, sedation and analgesia management, temperature management, osmotic pressure management, lumbar puncture pressure measurement

Eligibility criteria:
inclusion criteria: aneurysmal subarachnoid hemorrhage (asah), traumatic brain injury (tbi), acute deficiency blood stroke (ais), acute cerebral hemorrhage (ich), hypoxic ischemic encephalopathy (hie), sepsis-associated encephalopathy (sae), intracranial tumor surgery; older than 18 years old, \<85 years old; patients who need lumbar puncture. exclusion criteria: 1. age \<18 years old; 2. pregnancy; 3. the condition of the temporal window is limited and the image cannot be obtained; 4. the frequency spectrum of bilateral cerebral arteries shows stenosis; 5. patients with cerebral artery stenosis 6. patients who have not obtained informed consent;

Keywords: transcranial doppler（tcd）,intracranial pressure(icp)
cultivating resilience in oncology practice

Conditions: Childhood Cancer; Depressive Symptoms; Anxiety Disorders and Symptoms; Mental Health Issue

Summary: the purpose of the crop study is to investigate the potential to cultivate psychological resources and resilience in childhood cancer patients and their family members using a mobile phone-based intervention. the feasibility study aims to evaluate the implementation and participant experience of the digital intervention and register psychological outcome measures preliminary evidence for its acceptability, feasibility, and potential beneficial effects.

the feasibility study (crop) will recruit 20 youths with newly diagnosed cancer (10-18 y) and family members for participation in a 12-week digital intervention to cultivate psychological resources. investigators will recruit an equal number of pediatric patients with other chronic conditions to an observational comparison group to indicate the influences on participation and outcome from the oncology care context. investigators will obtain informed consent from all participants. upon inclusion in the study, participants will start getting a text message every day for 12 consecutive weeks. the texts will contain links to a digital platform on which participants will complete an exercise in either self-reflection or guided mindfulness meditation. the psychological training program is based on 12 modules with evidence-based treatments in other medical contexts and age groups. the practices are based on acceptance, commitment, re-appraisal, meaning and purpose, expressive writing, narrative processes, mindfulness, compassion, equanimity, and gratitude. the combination of practices and the implementation in pediatric oncology has not been studied earlier. the cancer patients will be recruited during the first month after diagnosis, meet with an instructor during 2-4 start-up meetings, and thereafter practice on their own or with participating family members. the pediatric patients with chronic diseases will be recruited during a follow-up visit to an out-patient clinic and meet with an instructor during 2-4 start-up meetings, and thereafter practice on their own or together with participating family members. investigators will address the primary research question of the feasibility of the intervention by investigating participant activity data, written evaluations of the experience of participation, and through phone interviews of participants. secondary research questions, such as preliminary data on changes in mental health and psychological distress, will be investigated with self-report questionnaires.

Eligibility criteria:
inclusion criteria: * newly diagnosed cancer * chronic pediatric disease exclusion criteria: * severe crisis reaction * late-stage palliative care * severe intellectual disability * psychiatric disease hindrance * participation in other study with psychological intervention
safety and efficacy of the unilexa exoskeleton for regular verticalization and assisted walking

Conditions: Spinal Cord Injury; Exoskeleton Device

Summary: the primary objective of this clinical follow-up is to analyze data regarding the safety of the unilexa passive exoskeleton post-market. the secondary objective is to assess the effectiveness of the device in improving activities of daily living (adl) through improved mobility, endurance and health-related quality of life (qol). the aim of this study is to provide real-world evidence to support wider clinical and home use of the exoskeleton. this observational study is designed for 6 participants from a population of individuals with lower limb paralysis. the study will have a duration of 14 weeks. during this period, participants will visit janske lazne three times for routine measurements in a biomechanical laboratory, which will be integrated into their usual physiotherapy sessions.


Eligibility criteria:
inclusion criteria: * individuals with lower limb paralysis due to spinal cord injury (t5-t12 lesion) in chronic phase (\> 6 months) * age 18 years and older. * asia score: ais a or ais b. * ability to provide informed consent and follow study procedures. * weight below 100 kg. * height between 165 - 195 cm. (pi can decide to include participants outside of this range. the ifu specifies an extended range of 160 - 200 cm with certain conditions.) exclusion criteria: * severe contractures in the lower limbs. * spasticity greater than 2 according to the modified ashworth scale (mas). * autonomic dysreflexia. * spinal instability. * untreated deep vein thrombosis. * untreated fractures of the pelvis or limbs. * advanced osteoporosis. * complete tetraplegia. * lack of upper limb control grade 3 or less, according to the asia test. * history of fracture due to osteoporosis. * medication that increases the chance of fracture.
evaluation of thymidine kinase activity in the serum of patients with solid tumors

Conditions: Solid Tumors

Summary: this study aimed to evaluate serum thymidine kinase 1 (tk1) activity as a marker for solid tumors and more specifically in: preoperative testing for prediction of disease recurrence and survival; follow-up after surgical removal of the original tumor for early detection of disease recurrence and in monitoring therapy as a surrogate marker of tumor response.

thymidine kinase 1 (tk1) is a metabolic enzyme catalyzing the atp-dependent phosphorylation of thymidine to thymidine monophosphate followed by its utilization in dna synthesis. it has been demonstrated that activity of tk1 in the serum of cancer patients corresponds to the amount of dividing tumor cells. several clinical investigations clearly showed that abnormal tk1 levels indicate tumor growth. in breast cancer, serum tk1 was shown to predict increased risk of recurrence following surgery and may be a good marker for monitoring the response to therapy. the measurements of tk1 were useful as a prognostic and monitoring factor in patients with nsclc. unfortunately, all previously used assays measuring tk1 activity showed relatively low analytical sensitivity. recently, the novel high sensitive non-radioactive tk1 assay (divitum) has been developed. with this assay tumour growth may be detected at an earlier stage of disease and smaller amounts of residual disease may be detected during and after therapy.

Eligibility criteria:
inclusion criteria: * patients with colon, breast, prostate and lung cancer before and during treatment exclusion criteria: * pregnant women; * patients with generalized cmv and hzv infections; * patients with severe rheumatoid arthritis

Keywords: thymidine kinase 1 activity diagnosis prognosis follow-up
study to evaluate efficacy and safety of an additional dose of celecoxib (ym177) in patients with post-tooth extraction pain

Conditions: Pain

Summary: to evaluate efficacy and safety of additional dose of celecoxib, as compared to placebo, in patients with post lateral mandibular impacted third molar tooth extraction pain.


Eligibility criteria:
inclusion criteria: initial dose: * 20 to 64 years * patients with undergoing mandibular impacted third molar tooth extraction accompanied by lateral bone removal and crown cutting * patients with pain that meets both of the following criteria * pain intensity (4-categorical): "moderate pain" or "severe pain" * pain intensity (vas): 45.0 mm or more additional dose: * patients with pain that corresponds to "4. agree" or "5. strongly agree" as the answer to the "question about the pain intensity" during the period from 5 hours to 12 hours post-initial dose of the study drug exclusion criteria: * patients with acute inflammatory findings in the oral cavity necessitating treatment * patients who are scheduled to receive general anesthesia and analgesics in the process of the eligible tooth extraction

Keywords: acute pain after oral surgery lateral mandibular impacted third molar tooth extraction
intensive vasodilator therapy in patients with essential hypertension

Conditions: Essential Hypertension; High Blood Pressure

Summary: the purpose of this study is to determine whether add-on of intensive vasodilator therapy can improve the coronary perfusion and reduce the total peripheral resistance in patients with ongoing treatment for essential hypertension.

morphological changes are observed in the microvasculature of patients with essential hypertension. the lumen diameter is reduced in resistance arteries, but with no change in vessel cross-sectional area or wall mass. these structural changes are termed inward eutrophic remodelling and results in an increased wall:lumen ratio, caused by rearrangement of cell matrix and not by hypertrophy of smooth muscle cells in the vascular wall as observed in secondary forms of hypertension. the morphological changes also occur in the coronary arteries and cause a reduction in the ability to increase coronary perfusion as response to increased cardiac work. this is observed as a reduced coronary flow reserve in patients with sustained hypertension. two recently published clinical studies associates an increase in media:lumen ratio with an increased risk of cardiovascular events, and it therefore seems beneficial to normalize the vascular structure in patients with essential hypertension. it has previously been demonstrated that reversion of vascular remodelling and thereby normalization of the vascular structure, requires vasodilatation and not just blood pressure reduction, suggesting that patients with essential hypertension can benefit from antihypertensive treatment aimed to induce vasodilatation. the purpose of this study is to determine whether add-on of intensive vasodilator therapy can improve the coronary perfusion (coronary flow reserve) and reduce the total peripheral resistance in patients with ongoing treatment for essential hypertension. we also aim to investigate whether changes in coronary flow reserve correlates better to changes in total peripheral resistance than changes in blood pressure. particularly we aim to study if patients with high total peripheral resistance, despite blood pressure control, can benefit from intensive vasodilating therapy.

Eligibility criteria:
inclusion criteria: * ongoing antihypertensive treatment for \>3 months * blood pressure \>120/75 during antihypertensive treatment * ejection fraction \> 45% exclusion criteria: * blood pressure \>160/100 * pregnancy * fertile women not using safe contraceptives * known secondary hypertension * valvular disease of haemodynamic significance * known endocrine disease, nephropathy or hepatic disease * present malignant disease * known psychiatric disease * abnormal lab tests of clinical significance * known allergy to any study medication * body mass index \> 35 * ongoing antihypertensive treatment with a combination of ace-inhibitor and calcium antagonist.

Keywords: inward eutrophic remodelling
basal bolus versus human insulin in hospitalized patients with diabetes in paraguay

Conditions: Hyperglycemia; Diabetes

Summary: few randomized studies have focused on the optimal management of non-icu patients with type 2 diabetes in latin america. objective: compare safety and efficacy of a basal bolus regimen with analogs and human insulins in general medicine patients admitted to a university hospital in asuncion, paraguay.

few randomized intervention inpatient trials have been conducted in latin america to determine optimal treatment regimens for patients with type 2 diabetes. in the absence of regional guidelines, most international societies in latin america recommend following international guidelines for the management of hospitalized patients with diabetes. however, hospital resources, admission cause and inpatient glycemic control differ among countries. in the us, the leading cause of admission to the hospital in patients with diabetes is cardiovascular disease, whereas infections and acute complications of diabetes are more common than cardiovascular disease in some countries. the safety and efficacy of insulin regimens in non-icu setting in latin countries have not been determined. objective: to compare the efficacy and safety of a basal-bolus regimen using insulin analogs with glargine once daily plus glulisine before meals to human insulin with nph twice daily and regular insulin before meals in medicine patients with type 2 diabetes outcome measures. to determine differences in glycemic control between groups as measured by mean daily bg concentration during the hospital stay. secondary outcomes included differences between treatment groups in any of the following measures: number of hypoglycemic events (bg \<70 mg/dl and \<40 mg/dl), total daily dose of insulin, length of hospital stay, hospital complications and mortality.

Eligibility criteria:
inclusion criteria: * age \>18 years * history of type 2 diabetes \> 1 month * treatment with diet alone, any combination of oral antidiabetic agents, and/or insulin prior to admission * absence of diabetic ketoacidosis exclusion criteria: * no history of diabetes * subjects expected to undergo surgery during the hospitalization course * clinically relevant hepatic disease * impaired renal function (serum creatinine ≥ 3.0 mg/dl) * pregnancy * any mental condition rendering the subject unable to give informed consent

Keywords: inpatient hospital randomized trial diabetes analogs human insulin
multimodal approach to testing the acute effects of mild traumatic brain injury (mtbi)

Conditions: Concussion, Mild

Summary: the objective of the study is to determine the relative roles for various testing modalities in the diagnosis and prognosis of mild traumatic brain injury.

subjects will undergo functional brain testing (magnetoencephalography, electroencephalography), anatomical brain imaging (diffusion tensor imaging, susceptibility-weighted imaging), neuropsychological testing (memory, language, processing speed), sleep patterns using actigraphy, and blood testing of candidate biomarkers. testing will be done at 3 time points post-injury: 1 day, 14 days, and 30 days post-injury. analysis of these tests collectively will be used to develop diagnostic tools for acute mtbi.

Eligibility criteria:
inclusion criteria: 1. civilian (non-military) presenting to hmh ed. exclusion criteria: 1. prior history of diagnosed tbi. 2. other significant non-head injury/trauma or open wound. 3. other significant medical co-morbidities, such as heart disease or cancer. 4. self-reported current use or substances contributing to ed visit (e.g. illicit drugs, medications, alcohol abuse). 5. currently diagnosed psychological condition (e.g. depression, ptsd). 6. medications for psychological or neurological disorder. 7. any implanted metal, such as medical device or braces on teeth. 8. injury to the back or other injury that will make it difficult for the participant to tolerate tests. 9. injury to dominant arm that would cause difficulty using computer or responding to stimuli during functional imaging. 10. pregnancy.

Keywords: mild traumatic injury to extremity (for controls) mtbi concussion meg eeg blood mri dti biomarkers
treatment of urge urinary incontinence in women after failure of cesa or vasa

Conditions: Surgical Treatment of Urge Incontinence

Summary: urge urinary incontinence can be a disorder caused by destroyed pelvic structures. we repaired the uteri-sacral ligaments (usl) by cesa or vasa. the study evaluates if solifenacin can lead to continence after surgery or if also the pubo-urethral ligaments (pul) need to be repaired.

it was hypothesized that urge urinary incontinence in women is based on the destruction of the uteri-sacral ligaments (usl)and the pubourethral ligaments (pul). in a preliminary study (urge i) we repaired the usl by cesa or vasa. those patients who are still incontinent after cesa and vasa get the repair of the pul by means of trans-obturator tapes (tot). that treatment is compared to conservative medical treatment. cross over after completion of three months is possible if no continence is achieved.

Eligibility criteria:
inclusion criteria: * prior vasa or cesa operation as part of the urge i study * stress urinary incontinence * mixed urinary incontinence exclusion criteria: * previous urogynecological surgery * avulsion of cesa or vasa tape * pregnancy * neurologic/psychological reasons for incontinence * body weight \>100kg * syndrome of dry overactive bladder

Keywords: urge urinary incontinence, cesa, vasa, tot, solifenacin
evaluation of different g6pd testing platforms

Conditions: Glucose-6-Phosphate Dehydrogenase Deficiency

Summary: in this study the investigators propose to evaluate the performance of several g6pd testing platforms.

in this study we propose to evaluate the performance of several g6pd testing platforms. we will also determine the concordance between point-of-care g6pd tests and the spectrophotometric gold standard. this study will also access the sensitivity and specificity between the point-of-care g6pd tests. this study will take place in indonesia, specifically in the sw sumba region. we will enroll 700 volunteers.

Eligibility criteria:
inclusion criteria: * subjects must be at least five years of age * patient / parental consent * patient willing to allow donated sample to be used in future research exclusion criteria: * patients with severe malaria or other severe illness * patients who received a blood transfusion in the last three months * patients unwilling to allow donated blood to be used in future research

Keywords: glucose-6-phosphate dehydrogenase point-of-care diagnostic testing
ethinyl estradiol and cyproterone acetate in irregular menstruation

Conditions: Amenorrhea; Dysmenorrhea; Menstruation Disturbances; Hyperandrogenism

Summary: this is a phase iv, randomized, double-blind, comparative study of the use of two preparations of ethinyl estradiol and cyproterone acetate in the treatment of menstrual irregularities of hyper-androgenic origin.


Eligibility criteria:
inclusion criteria: * female subject * premenopausal subject * 18 years or older * medical history of irregular menses lasting at least 3 months * signature of informed consent exclusion criteria: * pregnancy * use of hormonal contraceptives within 3 months of screening * primary bilateral oophorectomy * chemotherapy and / or radiotherapy within 6 months of screening * hysterectomy * myotonic dystrophy * galactosemia * galactorrhea * history of tuberculosis or schistosomiasis * elevated prolactin / other significant laboratory alterations * diabetes * premature ovarian deficiency * sensitivity to any component of the drug formula

Keywords: menstrual irregularity menstruation disturbances hyperandrogenism
stress hormones, mood and women's sexual desire (modest)

Conditions: Hypoactive Sexual Desire Disorder (HSDD)

Summary: women with hypoactive sexual desire disorder (hsdd) have all measures of testosterone activity comparable to controls but lower levels of dehydroepiandrosterone (dhea). although dhea is a precursor of testosterone it has other actions including involvement in the stress system. it is also linked to mood. this study focuses on measures of childhood stress, current mood and salivary stress hormones, in women with and without hsdd. we hypothesize that low levels of dhea reflect dysfunction of the neuroendocrine stress response system involving the brain, pituitary and adrenal glands where dhea is produced.


Eligibility criteria:
inclusion criteria for hsdd group: * (1) diagnosis of hsdd * (2) over 19 years of age * (3) sexual complaints of low desire of at least 12 months duration. inclusion criteria for control group: * (1) sexually healthy, i.e., must not meet criteria for any sexual dysfunction, as determined by a telephone screening, followed by an in-person structured assessment, the decreased sexual desire screener (dsds) * (2) over 19 years of age. exclusion criteria for both control and hsdd groups: * (1) lack of fluency in english * (2) currently meeting dsm-iv-tr diagnostic criteria for major depressive disorder as measured by an in-person, semi-structured interview based on the major depressive disorder module of the structured clinical interview for dsm-iv-tr (scid-i * (3) current use of prescription drugs such as antidepressants or other medications with known sexual side effects (e.g., glucocorticoids, aromatase inhibitors), or known effects on cortisol metabolism, or use of illicit drugs * (4) use of hormone replacement therapy or hormonal contraceptives; * (5) a body mass index (bmi) \ 29.9 * (6) cigarette smoking * (7) chronic medical or psychiatric disease with potential to interfere with sexual function (e.g., chronic neurological disease, cardiac and liver disease, eating disorders, anxiety disorders) * (8) chronic pain with intercourse not relieved by a vaginal lubricant * (9) loss of genital responsiveness * (10) significant relationship discord * (11) not having a family physician who we could contact if depression is diagnosed during the assessment * (12) difficulty in complying with questionnaires or in completing interview.

Keywords: hypoactive sexual desire disorder hsdd cortisol dhea stress hormones sexual desire mood sexual function childhood maltreatment childhood abuse
strength training for injury prevention

Conditions: Wounds and Injuries

Summary: the purpose of this study is to explore the effects of a strength \& conditioning (s \& c) program on risk factors for injury (y-balance and functional movement screen scores), as well as parent reported injury occurrence in 12-16 year old male and female athletes. forty girls and 40 boys aged 12-16 will be recruited; half will participate in supervised s \& c sessions 2-3x/week while the other half will continue with their regular sports and activities. risk factors for injury and performance indices (20 m sprint and multiple jump test) will be assessed before and after the 4 month study. injury occurrence will be recorded via bi-weekly phone calls to the parent and athlete.


Eligibility criteria:
inclusion criteria: * athletes between 12 and 16 years of age, actively participating in organized sport exclusion criteria: * any condition or injury that will place the athlete at risk during testing or training