Kornimate/medical-research-clean huggingface dataset:
post-surgical morbidity and bone healing of impacted lower third molars: piezosurgery vs. conventional instruments

Conditions: Impacted Third Molar Tooth

Summary: the aim of this study is to compare piezosurgery and conventional surgery in impacted third molar surgery and to determine its effect on postoperative outcomes and quality of life.

the aim of our study is to comparatively evaluate the duration of the operation and the pain, trismus, edema and healing of the alveolar bone that occur after tooth extraction in surgical extractions of impacted lower third molar teeth using piezosurgery and traditional rotary instruments.

Eligibility criteria:
inclusion criteria: * asa i-ii * aged 18-35 * symmetrical class 2 position b according to winter and pell-gregory classification * asymptomatic lower third molar tooth with the same difficulty according to the yuasa difficulty index exclusion criteria: * individuals who had systemic disease affecting bone or soft tissue metabolism * smokers (more than 10 cigarettes a day) * alcohol dependent * systemic disease affecting bone or soft tissue metabolism * acute pericoronitis or acute periodontal disease at the time of operation, and used antibiotics due to acute infection
covid-19 survey study on dietary intake, physical activity and overall well-being

Conditions: ALL, Adult

Summary: the aim of this research is to collect dietary intake, physical activity, mood and stress data during and after the illinois shelter-in-place and social distancing orders for the covid-19 pandemic. the study's intent is to capture data during this unprecedented time to understand the non-infection consequences of social distancing and shelter-in-place, including duration of affect after orders are lifted.

the proposed study is an observational study. the study will include our previous subjects, those who are following the shelter- in- place order due to the covid-19 pandemic. demographic data of individuals participating in the study will be recorded. during this 12-month protocol, participants will be contacted through email to complete online questionnaires on weekly basis for 8 weeks, and then once every 4 weeks until the end of the study. subjects will record their one-day food intake, physical activity, sleep, and stress and anxiety level, which takes \~1 hour to complete. subjects will be recruited through our cnrc databases of individuals who come to our clinic in the past 1 year, online advertisement, and word of mouth. a phone and/or email will be administered to ensure their eligibility using our standard tools and protocols. people who are willing and able to participate and meet the basic screening eligibility will be contacted through email for informed consent and the continuing of the study.

Eligibility criteria:
inclusion criteria: * able to provide informed consent * able to comply and perform the procedures requested by the protocol exclusion criteria: * n/a
experiment to assess preferences for novel hormonal therapy and androgen-deprivation therapy in prostate cancer patients

Conditions: Prostate Cancer

Summary: the purpose of this study is to quantify the preferences for novel hormonal therapy (nht) +/- androgen-deprivation therapy (adt) vs adt monotherapy among patients with non-metastatic hormone-sensitive prostate cancer (pc) in the united states (us), germany, spain, france, italy, the united kingdom (uk), south korea, australia, and brazil, using a discrete choice experiment (dce).

the study will collect data from eligible patients (six total) and physicians (six total) from one-on-one qualitative interviews and eligible patients from online surveys. approximately 330 patients with pc will be recruited to complete the online dce survey.

Eligibility criteria:
inclusion criteria: physician inclusion criteria * the physician is a certified urologist or oncologist. the final selection will be adjusted to local practice. * the physician has cared for at least ten nmhspc patients in the past year. * the physician has experience prescribing nht and adt. patient inclusion criteria * the patient has nmhspc after radiotheraphy (rt) and/or radical prostatectomy (rp), defined as an adult patient with nmpc who had rt and/or rp. exclusion criteria: physician exclusion criteria * none patient exclusion criteria * the patient is castration resistant. * the patient has metastatic pc.

Keywords: prostate cancer novel hormonal therapy androgen-deprivation therapy
improvement adherence to clinical practice guidelines using the clinical decision support system in patients with hypertension and atrial fibrillation

Conditions: Atrial Fibrillation; Arterial Hypertension

Summary: the clinical decision support systems (cdss) based on real clinical data and its own algorithms can help to make the right choice according to guidelines. the goal of the intellect ii study is to investigate treatment adherence to guidelines/science-based medicine and its impact on patient outcomes into two groups of doctors, clinical centers with standard care of treatment (control), and clinical centers using cdss (active).

hypertension and atrial fibrillation are 2 important public health priorities. there is a gap between evidence-based best management and actual clinical practice. to decrease this gap, clinical practice guidelines (cpgs), based on available evidence are employed. clinical decision support system ("medicbk") is a computer-based program that analyzes published evidence and provides prompts and reminders to assist health care providers in implementing clinical guidelines and science-based medicine at the point of care. the intellect ii trial is designed as a multicenter, cluster-randomized, single-blind, controlled study with blinded outcome assessment. approximately 10 centers from russia will be enrolled. centers managing patients with symptomatic atrial fibrillation and/or hypertension will be randomized to either patient management with aid of cdss ("medicbk") or standard care.

Eligibility criteria:
inclusion criteria: * age \> 18 years old * patients diagnosed with nonvalvular atrial fibrillation and hypertension and indications for therapy according to european guidelines. exclusion criteria: * inability to adhere to study procedures * severe heart-valve disorder * stroke within 14 days or severe stroke within 6 months before screening * active bleedings * thyroid dysfunction * pregnancy * secondary hypertension

Keywords: clinical practice guidelines clinical decision support systems adherence to guidelines evidence-based medicine
dural tenting sutures in neurosurgery - is it necessary?

Conditions: Epidural Hematoma

Summary: this study evaluates the necessity of dural tenting sutures in craniotomies. the sutures elevate the dura, a layer between the brain and skull. supposedly, by doing so, they prevent blood collecting between dura mater and the skull. these blood collections, called epidural hematomas, contributed greatly to postoperative mortality in the early days of neurosurgery. there have been several reports questioning the ongoing need for them in neurosurgery, thanks to modern hemostatic techniques. moreover, it has been published in the literature, and is a common knowledge as well, that some neurosurgeons do not use these sutures at all, and do not have worse outcomes than their colleagues. in this study, half of the randomly assigned participants will undergo craniotomy without dural tenting sutures and will be considered an intervention group. the other half will undergo craniotomy with these sutures.

in the early days of neurosurgery, epidural hemorrhages (edh) contributed to a high mortality rate after craniotomies. almost a century ago walter dandy reported dural tenting sutures as an effective way of preventing postoperative edh. over time, his technique gained in popularity and significance to finally become a neurosurgical standard. yet, there have been several retrospective reports questioning the ongoing need for dural tenting sutures. dandy's explanation that the hemostasis under hypotensive conditions is deceiving and eventually causes edh may be obsolete. these days, proper intra- and postoperative care, including maintenance of normovolemia and normotension and the use of modern hemostatic agents, may be enough for effective hemostasis. evading of this suturing technique by some surgeons supports this argument even further. thus, there is a fundamental need to evaluate the necessity of dural tenting sutures in an unbiased, evidence-based manner.

Eligibility criteria:
inclusion criteria: * male or female over 18 and under 75 years old * qualified for an elective supratentorial craniotomy with a diameter of at least 3 cm * glasgow coma scale 15 preoperatively * modified rankin scale 0, 1 or 2 preoperatively exclusion criteria: * coagulation abnormalities before the surgery * revision craniotomy * skull base surgery

Keywords: craniotomy dural tenting suture epidural hematoma
the compatibility of preoperative endometrial biopsies with postoperative final pathology in endometrial cancer

Conditions: Endometrial Cancer Stage; Gynecologic Cancer

Summary: although there are many studies comparing preoperative and postoperative histological diagnoses in the literature, there are no studies evaluating the compatibility of preoperative histological diagnoses obtained from different centers with postoperative histological diagnoses.therefore, in our study, we aimed to determine whether preoperative pathological specimens need to be re-evaluated in the referenced hospitals by comparing the compatibility of endometrial specimens in secondary care and tertiary centers with their final pathologies.in our study, we aimed to reveal the under and overdiagnosis rates of the preoperative histological diagnoses of our hospitals compared to the final pathology.

medical data of 960 patients diagnosed with endometrial cancer by endometrial biopsy between 2002 and 2016 were retrospectively analyzed. of these patients, 41 were excluded from the study due to non-surgical treatment, 254 patients having biopsy only in one center preoperatively, and lack of medical data in 52 patients.the study included 613 patients who had preoperative endometrial biopsy specimens evaluated by two different centers, diagnosed with endometrial cancer and treated surgically. our study was conducted in the gynecological oncology department of our university after obtaining the approval of the ethics committee numbered 430-2019.the clinicopathological characteristics of the patients were evaluated by examining the hospital records of age, gravida, parity, bm (body mass index), menopausal status and systemic diseases. histopathological and clinical features of endometrial cancer were reviewed.in this study, endometrial biopsy samples taken in the second stage state hospital were re-evaluated by the gynecopathologist working at the university hospital and / or the evaluation process was carried out in two steps by examining the repeated endometrial biopsy sampling.patients diagnosed with endometrial cancer were treated surgically in our clinic. endometrial sampling results based on uterine cancer risk groups; while histologically endometrioid and nonendometrioid were evaluated in two groups, the greade1-2 (low risk), greade3 (high risk) of uterine cancer were evaluated in four groups as those without malingnancy (benign and premaling lesions).by comparing these preoperative histological diagnoses with postoperative surgical final pathology, the accuracy rates for histological type and greade were determined. in addition, lower diagnosis, comorbidity and higher diagnosis rates compared to final pathology were examined for two different centers.

Eligibility criteria:
inclusion criteria: * female patients aged 40-90 years diagnosed with endometrial cancer according to endometrial sampling results exclusion criteria: * lack of medical data * endometrial sampling in only one center

Keywords: preoperative endometrial biopsies postoperative final pathology endometrial cancer
a study to evaluate patient experience in the therapy of neuroendocrine tumors treated with octreotide long acting release versus lanreotide

Conditions: Neuroendocrine Tumors

Summary: this study is being done to evaluate differences in patient experience during treatment with octreotide lar and lanreotide.


Eligibility criteria:
inclusion criteria: * willing and able to provide written informed consent for the trial * ≥ 18 years of age * histologically- or cytologically- confirmed locally advanced or metastatic wdnet * ssa therapy is recommended by physician for disease management, and has not yet begun * ecog performance status of 0, 1, or 2 exclusion criteria: * currently participating in a study of an investigational agent * prior chemotherapy, targeted small molecule therapy within 2 weeks prior to study day 1 or not recovered (i.e., ≤ grade 1 or at baseline) from adverse events due to a previously administered agent \*note: subjects with ≤ grade 2 neuropathy or ≤ grade 2 alopecia are an exception to this criterion and may qualify for the study * no concurrent chemotherapy or targeted small molecule therapy * if received major surgery, not recovered adequately from the toxicity and/or complications from the intervention prior to starting the study * known additional malignancy that is progressing or requires active treatment * active infection requiring systemic therapy * known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial

Keywords: octreotide lanreotide 17-422
high-concentration small-volume versus low-concentration large-volume iodine solution for esophageal chromoendoscopy

Conditions: Esophageal Squamous Cell Carcinoma

Summary: this clinical trial aims to test the participants' tolerance for different concentration iodine solutions during esophageal chromoendoscopy. the main question it aims to answer is: under the same iodine dosage, do the participants have the same tolerance for 1% and 5% iodine solutions? participants will be asked to score based on pain and discomfort and describe symptoms and corresponding location at 5 minutes (only for unanesthetized participants) and 30 minutes after chromoendoscopy.

lugol's iodine chromoendoscopy is the commonly used method for detecting and diagnosing esophageal squamous cell carcinoma. however, iodine can induce mucosal irritation and has been commonly associated with adverse retrosternal symptoms, including retrosternal pain and/or heartburn. the existing research shows that spraying iodine solution neutralizers (sodium thiosulfate solution, n-acetylcysteine, and vitamin c solution) after esophageal iodine chromoendoscopy can alleviate patient discomfort. however, a recent study has shown that excessive iodine concentration or excessive dosage of iodine can still increase patient discomfort even under spraying an iodine solution neutralizer. it is currently unclear whether the factors affecting patient tolerance are the iodine solution concentration or the total dosage of iodine used. therefore, the multicenter randomized controlled trial will compare the patient's tolerance for the 1% and 5% iodine solutions under the same iodine dosage conditions. the trial will help determine the specific reasons influencing patient tolerance. participants will be asked to score based on pain and discomfort and describe symptoms and corresponding location at 5 minutes (only for unanesthetized participants) and 30 minutes after chromoendoscopy.

Eligibility criteria:
inclusion criteria: * patients undergoing esophageal lugol's iodine chromoendoscopy. * age ≥ 18 exclusion criteria: * patients allergic to iodine or with hyperthyroidism; * patients with esophageal varices, esophageal ulcer or other conditions inadvisable for lugol chromoendoscopy; * patients with severe gastroesophageal reflux disease or reflux symptoms which may interfered with the outcome measures of current study; * patients with postoperative esophageal stenosis affecting endoscopic observation; * patients who could not cooperate with the observation and data collection including patients with mental disorders, severe neurosis, dysgnosia or communication disorder; * patients with advanced-stage tumors; * patients after upper gastrointestinal surgery; * patients who do not agree to sign informed consent forms or follow the trial requirement.

Keywords: lugol chromoendoscopy adverse event
minipterional versus pterional craniotomy

Conditions: Intracranial Aneurysm; Muscular Atrophy

Summary: this randomized prospective study was designed to compare the clinical, functional and aesthetic results of two surgical techniques for microsurgical clipping of anterior circulation aneurysms

this randomized prospective study was designed to compare the clinical, functional and aesthetic results of two surgical techniques for microsurgical clipping of anterior circulation aneurysms. overall, 60 eligible patients admitted with ruptured and unruptured anterior circulation aneurysms will enrolled in the study. the aesthetic results will be analyzed with 2 methods. in the first, the patients will be showed to a rule, with a scale from 0 to 100, in which 0 mean the best result and 100 the worst result. photos will be taken and showed to two independent observers, the results will be classified as excellent, good, regular or poor. the degree of atrophy will be measured with three methods. in the first one, the authors wiil observes the percentage of thick reduction in the temporal muscle, subcutaneous tissue and skin. in the second method the percentage thick reduction of the isolated temporal muscle will be measured and the third the volumetric analysis of the temporal muscle, subcutaneous tissue and skin will be calculated from the superior edge of zygomatic arch to superior temporal line. the functional results wiil be compared using the modified rankin score. others variables such frontal facial palsy, post-operative hemorrhage, cerebrospinal fistulas, hydrocephalus and mortality will be also analyzed

Eligibility criteria:
inclusion criteria: diagnosis of intracranial aneurysms exclusion criteria: giant aneurysms intracranial hematomas

Keywords: craniotomy, intracerebral aneurysms, atrophy, temporal muscle, outcome
j-pouch versus side-to-end coloanal anastomosis after preoperative radiotherapy and total mesorectal excision for rectal cancer

Conditions: Rectal Cancer

Summary: the objective of this study was to compare the functional and surgical results of the j-pouch with those of the side-to-end anastomosis and their impact on quality of life.

invalidating anorectal dysfunctions are common after restorative rectal surgery. improvement of functional results by the technically more demanding j-pouch has been demonstrated in comparison with the straight coloanal anastomosis. in the present multicenter randomized trial we assessed whether the j-pouch is also superior to the side-to-end coloanal anastomosis.

Eligibility criteria:
inclusion criteria: * the inclusion criteria comprised a histologically proven rectal cancer located in the middle or distal part of the rectum (≤ 10cm from the anal verge), and a who performance status ≤ 2. exclusion criteria: * patients with a t1 or t4 tumor were excluded * patients diagnosed with distant metastases * a medical history of colonic resection * anorectal surgery or chemo- radiotherapy * pre-existing fecal incontinence grade iii or iv according to parks10 * life expectancy of less than one year.

Keywords: rectal cancer colonic pouch side-to-end anastomosis preoperative radiotherapy
present- versus past-focused therapy for ptsd and substance use disorder

Conditions: Posttraumatic Stress Disorder; Substance Use Disorder; Alcohol Use Disorder

Summary: this study compares creating change, a new past-focused behavioral therapy for posttraumatic stress disorder (ptsd)/substance use disorder (sud), to seeking safety, an evidence-based present-focused behavioral therapy for ptsd/sud.

this study evaluates a new behavioral therapy model, creating change (cc) for ptsd/sud. cc helps clients explore the past as a step in their recovery process. it has major public health relevance in that it is a low-cost, flexible model designed for all trauma and substance abuse types, both genders, and all clinical settings. it has particular relevance for va in that many veterans suffer from ptsd and sud. the new model demonstrated positive results in two pilot studies.

Eligibility criteria:
inclusion criteria: * meet diagnostic and statistical manual (dsm-iv) criteria for current ptsd and current substance use disorder * have used a substance in the 60 days prior to intake * outpatient * plan to stay in boston for the next 6 months * if on psychiatric medication, are on a stable regimen for at least 4 weeks prior to participation in the study * have a stable mailing address and live nearby enough to come to va boston for treatment * able to sign informed consent * willing to participate in all assessments and urine testing * willing to provide a release of information for study staff to contact treaters as needed for clinical concerns exclusion criteria: * any current acute medical condition that would either interfere with the patient's ability to attend treatment, or would be of such severity as to affect the patient's psychological functioning * current bipolar i disorder, schizophrenia or other psychotic disorders, mental retardation, or organic mental disorder * any obvious clinical sign that the patient is not sufficiently stable to participate in the treatment, or notification by the patient's primary providers that participation would be contraindicated * dangerousness that would present a threat to staff or patients (e.g., history of assault within the past 6 months) * the patient is mandated to treatment

Keywords: posttraumatic stress disorder substance use disorder treatment efficacy randomized trial trauma substance abuse addiction
comparison of perfusion index, t wave amplitude, systolic blood pressure and heart rate

Conditions: Injections, Intravenous

Summary: the purpose of this study is to determine whether changes in perfusion index can be used for detecting intravascular injection of an epinephrine in anesthetized adults and to compare its reliability with criteria using changes in heart rate, systolic blood pressure or t-wave amplitude.

intravenous injection of local anesthetics could result in life-threatening complications during general anesthesia. physicians usually use local anesthetics containing epinephrine to detect intravascular injection. existing methods including heart rate, systolic blood pressure and t-wave amplitude are unreliable to detect intravascular injection during anesthesia and a method using changes in perfusion index was recently suggested. this study was designed to determine whether perfusion index is a reliable method to detect intravascular injection of epinephrine containing local anesthetics and to compare its reliability with conventional criteria in sevoflurane anesthetized adults. we will randomize patients to 2 groups: a saline group and an epinephrine group. changes in perfusion index, systolic blood pressure, heart rate and t-wave amplitude will be measured during 5 minutes after injection of 3 ml of saline or 1% lidocaine containing epinephrine. we will determine sensitivity, specificity, positive predictive value and negative predictive value.

Eligibility criteria:
inclusion criteria: * asa physical status 1 patients undergoing general anesthesia for elective surgery exclusion criteria: * emergent operation * those who are taking anticoagulant medication, calcium channel blockers, or b-blockers * laparoscopic operation * history of smoking

Keywords: anesthesia, general blood pressure epinephrine heart rate injections, intravenous