Kornimate/medical-research-clean huggingface dataset:
before and after erythrocyte suspension transfusion

Conditions: Anemia; Oxidative Stress

Summary: hypoperfusion, hypoxia and ischemia occurs in circulation as a result of anemia. all of these situations lead to oxidative stress and endothelial dysfunction in the organism. in this study, the investigators aimed to investigate the oxidant-antioxidant balance and asymmetric dimethylarginine (adma) levels in patients that have symptomatic anemia in need of erythrocyte suspension (es) transfusion. to the best of the investigators knowledge, there have been few studies in the literature on anemia and total oxidant, total antioxidant and adma levels. we aimed to observe changes in oxidative - antioxidant adma levels before and after es transfusion.


Eligibility criteria:
inclusion criteria: * only patients with deep anemia and anemia due to gastrointestinal bleeding patients in need of erythrocyte suspension transfusion were included. exclusion criteria: * patients with history of hypertension, diabetes, coronary artery disease, congestive heart failure, chronic renal failure, liver failure were not included to the study

Keywords: erythrocyte suspension total antioxidant status total oxidant status asymmetric dimethylarginine
evaluation of lung function and symptoms in patients diagnosed with chronic obstructive pulmonary disease (copd) on long-acting bronchodilator monotherapy

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: a multicenter study to evaluate lung function and symptoms in subjects with copd who have been on regular use of only one long-acting bronchodilator.


Eligibility criteria:
inclusion criteria: * cigarette smoking history-current or ex-smokers (defined as stopped smoking for at least three months prior to the study visit) * established history of copd as diagnosed by a physician * regular use (prescribed for use every day) of only one long-acting bronchodilator greater than or equal to one month before the study visit * ability to read, comprehend, and record information in the english language exclusion criteria: * currently active asthma (receiving asthma therapy and or having asthma symptoms) * use of ipratropium/albuterol combination products greater than three times per day, use of inhaled corticosteroids, use of inhaled corticosteroid/long-acting beta-agonist combinations, theophylline preparations, or oral beta agonists within 3 months prior to the study visit * previous lung surgery * other respiratory disorders other than copd * current alcohol, illegal drug, or solvent abuse * females with a positive urine pregnancy test at the study visit

Keywords: chronic obstructive pulmonary disease (copd) spirometry
echinacea, propolis and vitamin c for uri prevention in preschoolers

Conditions: Common Cold; Gastroenteritis

Summary: we hypothesize the herbal preparation will enhance the preschoolers' immune response and when taken prophylactically for 12 weeks will decrease episodes of upper respiratory infections and gastroenteritis in the active versus the control group.

this combination of herbs has been studied only once before in preschoolers. in a study of 430 preschoolers reported in archives of pediatric and adolescent medicine in march of 2004, a similar preparation with a slightly lower dose of vitamin c decreased upper respiratory infections by 55% (308 to 138). we are repeating this study to see if our results confirm or contradict those of the previous study.

Eligibility criteria:
inclusion criteria: * age 3-6 exclusion criteria: * cystic fibrosis * immunodeficiency * bronchopulmonary dysplasia * anatomic abnormalities of respiratory tract * intestinal malabsorption * allergy to sunflower seeds

Keywords: vitamin c echinacea propolis upper respiratory tract infection common cold gastroenteritis dietary supplement herbal remedy
delivering an evidence-based lifestyle intervention via the internet: a randomized controlled study

Conditions: Obesity

Summary: hershey medical center and the university of pittsburgh are doing a research study to help meet the needs of the adult population at risk for diabetes and heart disease. this study will provide a web-based program that aims to help participants to develop healthier eating habits, lose weight and become more physically active. the internet-based materials will teach participants about healthy eating and physical activity and will ask them to incorporate the information they learn into their daily lives. the purpose of this study is to evaluate the effectiveness of online lifestyle change programs to promote weight loss, healthy eating and physical activity patterns, in the interest of reducing risk for and adverse outcomes of type 2 diabetes (t2d) and cardiovascular disease (cvd).


Eligibility criteria:
please note: only individuals who receive primary care at one of the internal medicine clinics at milton s. hershey medical center in hershey, pa, are eligible for this study. inclusion criteria: * age between 18 and 80 years old * obese based on world health organization criteria (bmi\>30kg/m2) * receiving primary care from and referred by a provider at one of the internal medicine clinics at milton s. hershey medical center in hershey, pa * able to understand and sign an informed consent document * able to communicate with the investigator and understand the requirements of this study exclusion criteria * primary care provider determines that the individual is unable to safely undertake moderately intense unsupervised physical activity (the equivalent of 30 minutes of brisk walking) * primary care provider determines that the individual has inadequate cognitive function to participate in either active intervention curricula * women who are pregnant, who are planning to become pregnant in the next two years, or who become pregnant during the study * women who are breastfeeding * prisoners * children * individuals who are planning to have bariatric surgery or who have had bariatric surgery in the past two years * individuals with uncontrolled hypertension (systolic blood pressure (sbp) \>165, diastolic blood pressure (dbp) \>100) * individuals with an edematous state that interferes with body weight assessment (e.g., severe congestive heart failure, end- stage renal disease, or ascites), * individuals already using weight loss therapy * individuals with an inability to learn adequately from english language audio-taped materials * individuals with a lack of high-speed internet access (internet access will be based on participant perception; for example, participants could use computers belonging to friends, relatives, or libraries if they feel that they can access them regularly) * individuals without access to a scale * individuals unable to attend an orientation session at hershey medical center in hershey, pa

Keywords: obesity internet
how effective are antithrombotic therapies in primary percutaneous coronary intervention

Conditions: Acute ST Elevation Myocardial Infarction

Summary: the purpose of this study is to compare unfractionated heparin (ufh) and bivalirudin in the performance and subsequent outcomes of primary percutaneous coronary intervention. this will be a pragmatic trial. interventional procedures will be performed to reflect current and evolving standards, including predominant radial access. all patients will be treated with routine oral anti-platelet therapy pre-procedure. gp iib/iiia inhibitors will be reserved for 'bail out' treatment only.

heat-ppci is a single-centre prospective, dual-arm, open-label, randomised controlled trial comparing two antithrombotic agents in patients undergoing ppci. all patients presenting to the ppci service at liverpool heart and chest hospital will be assessed for trial eligibility. the patients will be allocated by randomisation in equal proportions to the two treatment groups receiving ufh (70 units/kg prior to the procedure) or bivalirudin (bolus of 0.75 mg/kg prior to the start of the intervention, followed by an infusion of 1.75 mg/kg per hour for the duration of the procedure). pre-specified subgroup analyses * subgroup analyses looking at the impact of access site comparing radial versus femoral route * assessment of the outcomes in diabetic patients receiving oral hypoglycaemic or insulin therapy versus all other patients * comparing the outcomes in patients \< or ≥ 75 years of age * type of p2y12 receptor inhibiting antiplatelet agent (examples: clopidogrel, prasugrel, ticagrelor) * patients with impaired lv function versus normal lv function * patients managed with actual or attempted primary pci versus no immediate pci procedure attempted platelet function substudy a substudy will be performed to assess indices of coagulation and platelet function studies comparing the impact of heparin or bivalirudin therapy on coagulation status at the end of the ppci procedure. this study will be performed on all patients treated between the hours of 0800 and 1600, monday to friday. a single blood sample taken at the time of general blood sampling for routine clinical screening will be analysed.

Eligibility criteria:
inclusion criteria: * all patients presenting with a suspected myocardial infarction event with ppci as the proposed index reperfusion strategy will be included in the trial exclusion criteria: * ≤ 18 years of age * known intolerance, hypersensitivity or contraindication to any trial medication * active bleeding at presentation * artificial ventilation, reduced conscious level or other factors precluding the administration of oral antiplatelet therapy * previous enrolment in this trial

Keywords: st elevation myocardial infarction primary percutaneous coronary intervention unfractionated heparin bivalirudin primary angioplasty
evaluation of the safety and efficacy of adjustable continence therapy balloons in bladder exstrophy and incontinent epispadias patients

Conditions: Bladder Exstrophy

Summary: the purpose of this study is to evaluate the effectiveness and safety of a minimally invasive surgical procedure with act (adjustable continence therapy) balloons implantation for the treatment of urinary incontinence in children with bladder exstrophy or isolated epispadias. the act therapy consists of two small adjustable silicone balloons connected with a tubing to a port, surgically placed around the bladder neck, one on each side of the urethra.


Eligibility criteria:
inclusion criteria: * boys and girls \> 5 years with bladder exstrophy or isolated epispadias; * sphincteric incontinence (leak point pressure \< 45 cm d'h20, open bladder neck during filling, stress urinary incontinence); * normal renal function (egfr \> 90ml/min); * no (or stable) upper urinary tract dilatation in ultrasound. exclusion criteria: * under 5 years or more than 18 years old; * renal insufficiency (acute or chronic); * evolutive deterioration of the upper urinary tract (hydronephrosis); * unmanageable detrusor instability; * residual volume greater than 100 ml after voiding; * bleeding disorders.
effective fraction of inspired oxygen with nasal cannula in premature infants

Conditions: Oxygen Therapy

Summary: the objective of this study is to determine the multifactorial relationship between the effective fraction of inspired oxygen (effective-fio2) and the fio2 in the gas delivered by the nasal cannula (nc-fio2), nc flow rate, spontaneous minute ventilation and other patient characteristics in premature infants who receive supplemental oxygen via nasal cannula (nc).

during routine nasal cannula (nc) use in the newborn icu, the actual fraction of oxygen inspired by the infant, i.e. the effective fio2 (effective-fio2) that reaches the infant's airways, cannot be easily determined. the effective fio2 during nc use is generally lower than the fio2 in the gas delivered by nc at the infant's nose due to dilution with ambient gas entrained by the infants during spontaneous inspiration. the factors influencing effective fio2 include the set fio2 of the gas delivered by nc (nc-fio2), the nc-flow rate, and the entrainment of ambient gas by the infant during each spontaneous inspiration. the individual contribution of each of these factors to the variability in effective-fio2 in extreme premature infants has not been systematically evaluated. the objective of this study is to determine the multifactorial relationship between the effective fraction of inspired oxygen (effective-fio2) and the fio2 in the gas delivered by the nasal cannula (nc-fio2), nc flow rate, spontaneous minute ventilation and other patient characteristics in premature infants who receive supplemental oxygen via nasal cannula (nc).

Eligibility criteria:
inclusion criteria: * premature infants born between 23 and 30 weeks of gestational age * receiving supplemental oxygen via nasal cannula * parental informed consent exclusion criteria: * major congenital anomalies * clinically unstable
mechanisms of acupuncture analgesia on experimental dental pain - a psychophysical study (phase1)

Conditions: Experimental Dental Pain

Summary: the investigators will assess the effects of manual acupuncture on experimental dental pain in 36 healthy subjects by means of subjective pain intensity ratings and pain-specific autonomic nervous system (ans) reactions.

this psychophysical and -physiological study is the first part of a two-phase project which pursues to explore how acupuncture-induced pain modulation interacts with pain-specific brain processing patterns by means of functional magnetic resonance imaging (fmri) and by using an experimental dental pain model. in this preceding study, the characterization of manual acupuncture effects on the experimental dental pain model will be tested under laboratory conditions and without restrictions of an fmri-measurement in order to provide a sound foundation for the following fmri-experiment. pain modulating effects of the manual acupuncture intervention (4 points: needle manipulation of bilateral large-intestine 4 (li4), stomach 6 and 7 (st6, st7) ipsilateral to the stimulated tooth) will be compared to sham-acupuncture (insertion and manipulation of 4 non-acupuncture points) and a control intervention (no acupuncture) which will each be performed at 3 different days in a randomized order. intervention effects on experimental dental pain will be assessed by testing of 36 healthy volunteers by means of subjective pain intensity ratings and pain-specific ans reactions such as electrodermal activity and heart rate/respiratory changes. besides laying the groundwork for the following fmri experiment, this study could provide valuable basic insights into the dynamics of the tested manual acupuncture effects and further provide important knowledge for the planning of future clinical studies encompassing dental conditions and development of acupuncture treatments.

Eligibility criteria:
inclusion criteria: * right-handed * written informed consent * fluent in german language * sufficient dental sensitivity for the tooth stimulation * no acupuncture treatment in the previous 12 months * no medical knowledge about acupuncure exclusion criteria: * alcohol, drug, and analgesics consumption within the last 24 hours * complaints of diseases of the oral cavity * pre-existing neurological and(or psychiatric conditions * history of severe dental pain * regular intake of pain medication * history of brain injuries * alcohol and drug abuse * chronic diseases that require a permanent intake of drugs

Keywords: manual acupuncture experimental dental pain psychophysics autonomic nervous system subjective pain ratings
the effects of two different types of exercise programs to increase physical activity in patients with ms

Conditions: Multiple Sclerosis

Summary: multiple sclerosis (ms) is a chronic, inflammatory, neurodegenerative, autoimmune disease of the central nervous system. it is thought that ms, which is one of the main causes of non-traumatic neurological dysfunction in young adults, affects approximately two and a half million people worldwide. the annual cost caused by ms is reported to be between $ 8,528 and $ 54,244 per patient. due to the destruction of the central nervous system, ms has a wide range of sensory, motor, cerebellar and cognitive dysfunctions. these dysfunctions may lead to a limitation of physical activity in people with ms. in addition, people with ms may limit their physical activity because they fear the worsening of their symptoms. physical inactivity and sedentary life style are thought to be among the reasons that increase the risk of developing chronic diseases such as cancer, hypercholesterolemia, hypertension, arthritis, osteoporosis, obesity, type 2 diabetes, depression and cardiovascular diseases in people with ms. it is reported that these chronic diseases secondary to ms increase mortality by 1.7 times. in addition, these diseases have been associated with increased disability, decreased quality of life, and hospitalization. physical inactivity can increase disability and mortality by aggravating health problems caused by the disease. for this reason, it is emphasized that there should be studies to increase physical activity in people with ms. studies have shown that physical activity improves muscle strength, aerobic capacity, gait and balance and reduces fatigue in people with ms. in addition, it is stated that physical activity increases self-efficacy and improves positive perspective in patients with ms. when the literature is examined, it is seen that there are studies about physical activity in ms but they have methodological limitations. there are a limited number of studies on the effectiveness of the programs planned to increase the level of physical activity. the aim of our study was to investigate the effects of physical activity program and online training program on physical activity in patients with ms.


Eligibility criteria:
inclusion criteria: * being diagnosed with multiple sclerosis * being between 25 and 60 age range * not having attacks during last 3 months * having ≤ 5.5 expanded disability status scale * not having received physiotherapy and rehabilitation sessions for at least 3 months * having internet access exclusion criteria: * pregnancy * blurred vision * use of assistive devices for ambulation * having another diagnosis rather than multiple sclerosis

Keywords: multiple sclerosis rehabilitation physical activity exercise
analysis of the toxicity and efficacy of daily 1 vs 2 beam proton therapy

Conditions: Chordoma; Chondrosarcoma; Ewing Sarcoma; Osteosarcoma

Summary: thanks to the intrinsic qualities of the proton beam, proton therapy will reduce adverse effects of irradiation. the proteus®one is the latest generation of proton therapy equipment, enabling the centre antoine lacassagne to expand its range of treatments by carrying out new proton therapy treatments. it has an innovative compact isocentric rotating head (gantry) that allows the radiation beam to be directed at different angles around the patient. in some cases, two beams are used to treat tumours, and by convention, both beams are delivered during the same session. however, it is necessary to position the patient before each beam, which is time-consuming because 2 beams have to be positioned very precisely each day. the aim of this study is therefore to assess the toxicity of proton therapy delivered by a single daily beam compared with proton therapy delivered by two daily beams, which is the conventional technique.


Eligibility criteria:
inclusion criteria: * chordoma, chondrosarcoma of the skull base and spine, ewing's sarcoma, and osteosarcoma meeting the criteria for treatment by proton therapy * tumour requiring 2 beams * mri less than one month old * ps 0-2. * patient who has read the patient information note and signed the consent form. * patient with healthcare insurance cover. * age over 18 years. * for women of childbearing age, negative urine pregnancy test and effective contraception in place for the duration of treatment and for six months following the end of treatment. exclusion criteria: * persons deprived of their liberty or under guardianship. * unable to undergo the medical follow-up of the clinical investigation for geographical, social or psychological reasons. * patient eligible for symptom reduction surgery vulnerable populations and participants defined in articles 64 to 68 of regulation (eu) 2017/745 of the european parliament and of the council of 5 april 2017.

Keywords: protontherapy
identification of new predictive osseointegration bio-markers of the prosthetic implant in patients with osteoarthritis

Conditions: Osteoarthritis

Summary: the study involves the isolation and cellular, molecular and proteomic characterization of synoviocytes, osteoblasts and chondrocytes from tissue samples obtained from patients undergoing surgery of endo or arthroplasty for osteoarthritis (experimental group) or interventions for other causes such as for example periarticular fracture requiring the implantation of a prosthesis (control group)

the study involves the isolation and cellular, molecular and proteomic characterization of synoviocytes, osteoblasts and chondrocytes from tissue samples obtained from patients undergoing surgery of endo or arthroplasty for osteoarthritis (experimental group) or interventions for other causes such as for example periarticular fracture requiring the implantation of a prosthesis (control group) deeper analysis of micro ribo nucleic acid (rna) and non coding rna expressed by the synoviocytes, osteoblasts and chondrocytes will be performed in order to understand their possible involvement in pathways of osteogenic differentiation, through suitable experimental in vitro models of co-cultures. in particular, investigators will focus on the cross-talk between synoviocytes and osteoblasts, cell populations involved in the post-surgical articular microenvironment and on which the osteointegration process of the joint prosthesis depends.

Eligibility criteria:
inclusion criteria: 1. male and female patients \> 40 years old hospitalized for surgery of endo- or arthroplasty for osteoarthritis or for surgery for joint traumatic diseases (eg femoral neck fractures) requiring the implantation of a prosthesis 2. interval of at least three months from any previous infiltrative treatment of any kind; 3. patients able to provide written informed consent to the study. exclusion criteria: 1. severe cognitive defects or psychiatric disorders; 2. tumor pathologies or concurrent antineoplastic therapies; 3. autoimmune diseases (rheumatoid arthritis); 4. surgery that involves the joint