Kornimate/medical-research-clean huggingface dataset:
psma-pet imaging for advanced acc/sdc

Conditions: Salivary Gland Cancer; Adenoid Cystic Carcinoma; Salivary Duct Carcinoma

Summary: diagnostic study which evaluates the level of psma expression in patients with locally advanced, recurrent and/or metastatic acc/sdc of ≥18 years old with 68ga-psma-pet/ct imaging in order to establish whether these patients are eligible for 177lu-psma therapy

rationale: psma is a transmembrane protein, which is expressed on prostate cancers cells, acc and other malignancies. in prostate cancer, distant metastases can be visualized sensitively and non-invasively with 68ga-psma-pet/ct scans and if the uptake of 68ga is high enough, patients can be treated with the β-emitting radionuclide 177lu-psma. in the current study, we will evaluate the uptake of 68ga-psma by performing 68ga-psma-pet/ct scans in advanced acc and sdc patients. if the uptake is high enough, this will form the rationale for a therapeutic study with 177lu-psma in acc and sdc. objective: the primary objective is to evaluate the uptake of 68ga-psma in locally advanced, recurrent and metastatic acc/sdc by performing 68ga-psma-pet/ct scans. the secondary objectives are to calculate the suv tumor-to-background ratio and tumor-to-'healthy salivary gland tissue' ratio. to correlate the suv to the degree of immunohistochemical psma expression of the primary tumor on archival tissue, and to establish whether new metastatic lesions are found by 68ga-psma-pet/ct imaging. study design: diagnostic study which evaluates the level of psma expression in acc/sdc patients with 68ga-psma-pet/ct imaging in order to establish whether these patients are eligible for 177lu-psma therapy. study population: patients with locally advanced, recurrent or metastatic acc/sdc of ≥18 years old.

Eligibility criteria:
inclusion criteria: * locally advanced, recurrent or metastatic acc/sdc * age ≥ 18 years old * ability to provide written informed consent exclusion criteria: * contra-indication for pet imaging * pregnancy * breast feeding * severe claustrophobia * impaired renal function: mdrd \<30 ml/min/1,73 m2 * impaired liver function: ast and alt ≥ 2.5 x uln (≥5 x uln for patients with liver metastases)

Keywords: 68ga-psma positron-emission tomography immunohistochemistry
hormones in vernal keratoconjunctivitis

Conditions: Conjunctivitis, Vernal

Summary: vkc is more common in males and tends to resolve with pubertal development. clinical observation was not followed by an investigation that clarified whether there is a correlation between the hormonal pattern and the evolution of the disease, in particular it is not defined whether there is a correlation between the hormonal pattern and the resolution of the disease. this study aims to evaluate the hormonal pattern in patients with vkc and, in particular, the possible role of these hormones in the resolution of this condition in puberty.

the study presents a retrospective and prospective transversal observational design, non-pharmacological, monocentric, non-profit. it is based on the collection of clinical, laboratory and therapy data on databases of patients affected by vernal keratoconjunctivitis. participation in the study will be proposed to parents of patients with vkc over 10 years of age at puberty (b2 according to tanner for females and g2 according to tanner for males), based on endocrinological evaluation. patients, differentiated by gender, will be divided into two groups: patients with active vkc and patients with resolved vkc. both study groups will be offered a blood sample to determine the serum levels of lh, fsh, estradiol, dheas, androstenedione, total testosterone, shbg, dht, 17oh-progesterone, tsh-r, albumin, acth and cortisol. in postpuberal females, the sample must be taken in the first 5 days of the menstrual cycle. this study provides for the enrollment of patients diagnosed with vkc followed at the allergy outpatient clinic of the uosd pediatrics high intensity of care - irccs ca 'granda foundation ospedale maggiore policlinico di milano. the source documentation of the data will be the medical record and the reports of the examinations, provided for by the study, performed at the institute. on the same day, a blood sample and a pubertal stage assessment will be performed. an allergy / ophthalmological examination for vkc will be carried out only if it had not been performed in the 12 months prior to the execution of the blood sample. there is no follow-up.

Eligibility criteria:
inclusion criteria: * diagnosis of vkc assessed by an allergologist or ophthalmologist over 10 years of age exclusion criteria: * presence of pre-existing pathologies of the endocrine system.
interleukin-2 in treating patients with metastatic kidney cancer

Conditions: Kidney Cancer

Summary: rationale: interleukin-2 may stimulate a person's white blood cells to kill cancer cells. it is not yet known which regimen of interleukin-2 is most effective for kidney cancer. purpose: randomized phase iii trial to compare the effectiveness of different regimens of interleukin-2 in treating patients who have metastatic kidney cancer.

objectives: i. determine the response rate and overall survival of patients with metastatic renal cell carcinoma treated with either low-dose or high-dose intravenous interleukin-2 (il-2) or subcutaneous il-2. ii. compare the toxic effects of these 3 regimens in this patient population. outline: this is a randomized study. patients are stratified according to presence of renal tumor (yes vs no). patients are randomized to one of three treatment arms. arm i: patients receive low dose interleukin-2 (il-2) iv every 8 hours for up to 15 doses. treatment repeats in 7-10 days for one complete course. arm ii: patients receive high dose il-2 iv every 8 hours for up to 15 doses. treatment repeats in 7-10 days for one complete course. arm iii: patients receive il-2 subcutaneously daily 5 days a week for 6 weeks. treatment continues in the absence of disease progression or unacceptable toxicity. patients with stable or responding disease receive an additional complete course of therapy. projected accrual: a total of 400 patients will be accrued for this study.

Eligibility criteria:
disease characteristics: histologically proven, metastatic renal cell carcinoma with measurable disease no more than 25% of liver replaced with tumor no cns involvement or major nerve compression allowed patient characteristics: age: 18 and over performance status: ecog 0-2 life expectancy: more than 3 months hematopoietic: not specified hepatic: bilirubin less than 2.0 mg/dl ast and alt no greater than 3 times normal renal: creatinine less than 1.6 mg/dl cardiovascular: normal ekg normal thallium stress test (required of patients 50 years of age and older or as clinically indicated) pulmonary: fev1 and vc greater than 65% of predicted (pulmonary function screening required of patients with significant smoking history or suspicion of pulmonary disease) other: no second malignancy, except: basal cell skin cancer carcinoma in situ of the cervix no significant psychiatric disease that would preclude consent or treatment no systemic infection no coagulation disorders or bleeding not pregnant hiv negative prior concurrent therapy: no prior therapy within 28 days biologic therapy: no prior interleukin-2 chemotherapy: not specified endocrine therapy: not specified radiotherapy: not specified surgery: not specified other: no concurrent steroids

Keywords: stage iv renal cell cancer recurrent renal cell cancer
muscle tissue oxygenation in patients with decompensated liver cirrhosis

Conditions: Liver Cirrhosis

Summary: patients with decompensated liver cirrhosis exhibit numerous hemodynamic and microvascular changes, i.e., low systemic blood pressure and peripheral vasodilatation. in addition, alterations of tissue oxygenation are described in these patients. near-infrared spectroscopy (nirs) has been proposed as a tool to quantify microvascular dysfunction, for example in patients with sepsis (1) or after trauma (2). nirs is a non-invasive technique that uses the differential absorption properties of oxygenated and desoxygenated hemoglobin to evaluate skeletal muscle oxygenation (3). up to the investigators' knowledge no data exist on nirs measurements in patients with decompensated liver cirrhosis. aims of this study are to evaluate: * are there any changes in nirs parameters in patients with decompensated liver cirrhosis in comparison to other critically ill patients (matched to saps ii score) or healthy individuals? * is there a correlation with common accepted prognostic scores (meld score or indocyanin green clearance) in decompensated liver cirrhosis patients and initial nirs parameters? * does the nirs trend within the first three days of icu care in decompensated liver cirrhosis patients receiving fluid replacement therapy correlate with the course of disease? 1. de backer d, creteur j, preiser jc, dubois mj, vincent jl. microvascular blood flow is altered in patients with sepsis. am j respir crit care med. 2002 jul 1;166(1):98-104. 2. creteur j. muscle sto2 in critically ill patients. curr opin crit care. 2008 jun;14(3):361-6. 3. creteur j, carollo t, soldati g, buchele g, de backer d, vincent jl. the prognostic value of muscle sto2 in septic patients. intensive care med. 2007 sep;33(9):1549-56.

patients fulfilling inclusion criteria and without exclusion criteria will be monitored by nirs using inspectra™ technology (hutchinson, usa) for the first three days of their icu hospitalization. besides registration of the nirs parameters (tissue hemoglobin saturation (sto2), total tissue hemoglobin (thi), dynamic test values by using occlusion testing) baseline characteristics (age, sex, saps ii score et.), disease relevant information (etiology of liver cirrhosis, cause of icu hospitalization) and icu data (catecholamine therapy, mechanical ventilation, hemodynamic monitoring, fluid therapy) will be recorded. within the observation time, an indocyanin green-clearance measurement and further laboratory testing will be performed on a daily basis. data will be pseudonymized and kept confidential according to the guidelines of the local ethics committee.

Eligibility criteria:
inclusion criteria: * patients with decompensated liver cirrhosis admitted to the medical icu * written informed consent signed by the patients or his/her closest family member * age ≥ 18year exclusion criteria: * no written informed consent signed by the patients or his/her closest family member

Keywords: decompensation septic shock tissue oxygenation near infrared spectroscopy
a study of jnj-90009530 in relapsed or refractory b-cell non-hodgkin lymphoma (r/r b-nhl)

Conditions: Relapsed or Refractory B Cell Non-Hodgkin Lymphoma

Summary: the goal of this multicenter study is to test jnj-90009530 in relapsed or refractory non-hodgkin lymphoma patients. the main questions the study aims to answer are: * can a dose of jnj-90009530 be determined that is safe and well tolerated by patients. * will jnj-90009530 help patients achieve a response and for how long?


Eligibility criteria:
key inclusion criteria * participant must be greater than or equal to (\>=) 18 years of age, at the time of signing informed consent * all participants must have relapsed or refractory disease for each histologic subtype * mature aggressive large b cell nhl and follicular lymphoma grade 3b: participants must have \>= 2 lines of systemic therapy or \>=1 line of systemic therapy in case of participants ineligible for high-dose chemotherapy and autologous hematopoietic stem cell transplantation (hsct). participants also must have had exposure to an anthracycline and an anti-cd20 targeted agent * follicular lymphoma grade 1-3a and marginal zone lymphoma: participants must have \>=2 prior lines of anti-neoplastic systemic therapy. participants also must have prior exposure to an anti-cd20 monoclonal antibody * tumor must be cluster of differentiation (cd) 20 positive * measurable disease as defined by lugano 2014 classification * eastern cooperative oncology group (ecog) performance status of either 0 or 1 key exclusion criteria * diagnosis of human herpes virus (hhv) 8-positive diffuse large b cell lymphoma (dlbcl) * prior allogeneic hematopoietic stem cell transplantation (hsct) * autologous stem cell transplant within 12 weeks of chimeric antigen receptor (car) t cell infusion * uncontrolled active infections * history of deep vein thrombosis or pulmonary embolism within six months of infusion (except for line associated deep vein thrombosis \[dvt\]) * history of stroke, unstable angina, myocardial infarction, congestive heart failure ( new york heart association \[nyha\] class iii or iv), severe cardiomyopathy or ventricular arrhythmia requiring medication or mechanical control within 6 months of screening * history of a seizure disorder, dementia, cerebellar disease or neurodegenerative disorder * known history or prior diagnosis of optic neuritis or other immunologic or inflammatory disease affecting the central nervous system * active central nervous system (cns) involvement by malignancy * current active liver or biliary disease (except for gilbert's syndrome or asymptomatic gallstones)
immersive v/s non-immersive virtual reality in enhancing upper limb functions among individuals with subacute stage hemiplegia

Conditions: Hemiplegia and/or Hemiparesis Following Stroke

Summary: the goal of this randomized controlled trial is to compare the effectiveness of immersive virtual reality combined with conventional therapy to the effectiveness of non-immersive virtual reality combined with conventional therapy in enhancing upper limb function in subacute hemiplegic stroke patients.

the study is a single blinded randomized controlled trial in which the assessor will be blinded. male and female participants aged between 28-55 years are included in the study. participants are selected based on inclusion and exclusion criteria and are later randomly assigned to group 1 and group 2. group 1 - conventional therapy and immersive virtual reality group 2 - conventional therapy and non-immersive virtual reality primary outcome measures include the fugl meyer assessment for upper limb and graded wolf motor function test for upper limb. secondary outcome measure is the stroke specific quality of life scale (ss-qol) questionnaire. therapy session starts with 15 minutes of stretching and strengthening exercises of the affected arm followed by 45 minutes of immersive / non immersive virtual reality training. follow up assessment is done 6 weeks post intervention. the baseline assessment score and follow up assessment scores will be compared.

Eligibility criteria:
inclusion criteria: * individuals aged 28-55 years. * diagnosed with hemiplegia due to stroke. * ≤ grade 2 on modified ashworth scale. * ≤ stage 2 on brunnstrom stages of motor recovery. * score of ≥ 35/36 on cognitive assessment scale for stroke patients (casp) exclusion criteria: * contraindications for vr therapy, such as severe motion sickness or photosensitive epilepsy, impaired spatial awareness. * pre-existing neurological conditions such as spinal cord injury, multiple sclerosis and so affecting upper limb function.

Keywords: virtual reality hemiplegic stroke oculus quest 3 motor function upper limb
increasing physical activity for adults with multiple sclerosis (ms)

Conditions: Multiple Sclerosis (MS); Fatigue; Physical Inactivity

Summary: this study aims to advance the scientific understanding and potential future implementation of physical activity promotion by testing the efficacy of a phone-based app for increasing activity in insufficiently active patients with multiple sclerosis (ms).

this study aims to test the efficacy of exerciserx, a free software platform designed to increase physical activity in people with multiple sclerosis (pwms). exercise is crucial for managing ms symptoms and overall health, but approximately 80% of pwms do not get enough physical activity due to barriers like physical limitations, common ms symptoms, and lack of community exercise facilities. exerciserx translates clinically relevant activity data collected by personal smart devices into actionable metrics on a dashboard within the epic electronic health record, allowing healthcare providers to prescribe and monitor tailored physical activity solutions for their patients. this study will test the effects of exerciserx in a sample of inactive pwms.

Eligibility criteria:
inclusion criteria: * provider-confirmed diagnosis of ms using revised 2017 mcdonald criteria * \> 18+ years of age * patient determined disease steps (pdds) score \< 3, indicating the potential for some gait disability although typically ambulates without an assistive device * insufficiently active, defined as \< 150 minutes of physical activity per week, assessed using the pavs in the ehr in clinics as part of the routine patient intake process * use of an iphone with software version ios13+ or an android phone 4.1+ * agree to install and use the exerciserx app for the entire study period and keep their phone on them during the daytime (e.g., pocket, bags, hands) exclusion criteria: * recent (past 4 weeks) or planned surgery during the study period which may impact engaging in step counts * ms relapse within the last 30 days * plans to travel internationally during the study period, which could interfere with server uploads of mobile phone data * those at a higher risk of falling or injury from falls or unable to safely exercise due to other medical conditions (e.g. heart conditions, diabetes or conditions made worse by walking or physical activity)
effectiveness of lavage with alcohol - chlorhexidine for chemical matricectomy

Conditions: Ingrown Toenail

Summary: to compare the efficacy of the lavage with 70% alcohol plus 0.5% chlorhexidine versus 70% alcohol in the surgical treatment of ingrown toenails.

the purpose of this study is to compare the efficacy of the lavage with 70% alcohol plus 0.5% chlorhexidine versus 70% alcohol during the phenolization procedure in the surgical treatment of ingrown toenails in patients undergoing for chemical matricectomy.

Eligibility criteria:
inclusion criteria: * older than 18 with onychocryptosis exclusion criteria: * infection, history of tinea pedis, onychomycosis, paronychia, nail trauma or subungual hematoma, nail deformities and disorders, peripheral vascular disease or diabetes, cardiac disease, history of rheumatic fever, recent antibiotic use or current antimicrobial therapy, history of steroid use and recent nail polish use

Keywords: phenol ingrown toenail chemical matricectomy
preoperative magnetic resonance imaging abnormalities predictive of lumbar herniation recurrence

Conditions: Lumbar Disc Herniation

Summary: there are currently no standard criteria for evaluating the risk of recurrent disk herniation following surgical repair. this study investigated the predictive values of five presurgical imaging parameters, paraspinal muscle quality, annular tear size, modic changes, modified pfirrmann's disc degeneration grade, and presence of sacralization or fusion. clinical status and mri findings were evaluated before surgery and 4, 12, and 24 months post-surgery using a visual analog scale (vas), oswestry disability index (odi), and short form 36 (sf36).


Eligibility criteria:
inclusion criteria: * first operation for a single-level lumbar disk herniation * no concurrent spinal pathology such as stenosis, spondylolisthesis, or deformity * complete data on clinical and radiological parameters exclusion criteria: * the operation was for multi-level pathologies * recurrent surgery * exhibited concurrent spinal pathology * was missing or incomplete clinical and radiological data
impact of mindful awareness practices in pediatric residency training

Conditions: Stress; Burnout, Professional

Summary: this study evaluates the effect of a standardized mindfulness based intervention compared to control on self-reported levels of stress in residency trainees.

recent research studies have indicated that the practice of mindfulness is strongly correlated with enhanced well-being and improved resilience in a variety of populations. mindfulness-based interventions have been shown to reduce stress and symptoms of burnout in physicians. however, the two studies that included residents were observational trials evaluating the effect of an abbreviated, informal mindfulness course. the aim of the investigator's study is to assess whether a standardized course in mindfulness meditation (mindful awareness practices, maps) reduces self--reported signs and symptoms of stress, burnout, depression, anxiety, loneliness and poor sleep quality in residents in pediatrics training. this study is a randomized controlled trial using 2 parallel groups. the pediatrics residents randomized to the intervention will participate in a standardized mindful awareness practices intervention consisting of one live 45- minute session and 5 web--based self--study sessions. the live session will be administered by a trained mindfulness educator at the ucla westwood, olive view medical center and cedars--sinai medical center campuses. the waitlist group will have the opportunity to participate in the same course once the study has been completed. participants will respond to questionnaires to assess for levels of stress and other mental health measures before and after the intervention to see if the intervention group had a reduction in symptoms compared to the waitlist group.

Eligibility criteria:
inclusion criteria: * pediatric resident at the university of california los angeles's mattel children's hospital * medicine/pediatric resident at university of california los angeles's mattel children's hospital exclusion criteria: -none

Keywords: mindfulness residency training
effectiveness of relaxation methods in total knee arthroplasty patients

Conditions: Knee Arthroplasty

Summary: in this study, the effectiveness of a comprehensive training program consisting of pain management, relaxation, breathing, massage and falling components will be investigated in patients with total knee arthroplasty. in this randomized controlled study, the trainings will be offered face-to-face after the initial evaluation and within the scope of telemedicine with prepared videos. the first evaluation will be performed on the first postoperative day and the last evaluation will be performed 3 months postoperatively. the aim of this study is to evaluate the effectiveness of a comprehensive education program consisting of pain management, relaxation, respiration, massage and fall components in patients with total knee arthroplasty.


Eligibility criteria:
inclusion criteria: * participants aged 50 and over * participants indicated for unilateral or bilateral total knee arthoplasty * individuals to be followed after surgery exclusion criteria: * other surgeries * individuals with neurological and orthopedic diagnoses * individuals with cognitive, hearing, speech and psychiatric problems that prevent them from communicating * illiterate individuals * presence of malignancy * not signing the consent form