Kornimate/medical-research-clean huggingface dataset:
eye movement desensitization and reprocessing (emdr) to treat chronic pruritus

Conditions: Chronic Pruritus

Summary: pruritus is a common symptom of numerous dermatological and non-dermatological conditions. current treatments for chronic pruritus (cp) are often not fully effective and may have burdensome side effects. recently, the trauma exposure technique eye movement desensitization and reprocessing (emdr) that is recommended as first line treatment for posttraumatic stress disorder has been reported to be also effective in the treatment of cp in anecdotal clinical case observations. however, to the best of the investigator's knowledge, the efficacy of emdr in cp has not yet been systematically explored. this study aims at addressing this unmet need in a prospective pilot study comparing emdr versus treatment as usual (tau).


Eligibility criteria:
inclusion criteria: * provided written informed consent * age 18 to 75 years * skindex-29 (questionnaire) symptoms subscale ≥42 * confirmed diagnosis cp * itch intensity of min. ≥ 4 on the 0-10 numerical rating scale within the last 7 days * stable course of treatment in the two weeks prior to the study exclusion criteria: * inability to follow the procedures of the study, e.g. due to language problems, severe psychiatric disorders such as delusional disorder, suicidality or dementia. * patients on phototherapy * acute attacks of an autoimmune disease such as crohn's disease * serious cardiac disease

Keywords: eye movement desensitization and reprocessing
frusemide infusion for the prevention of deterioration in renal function post cardiac surgery.

Conditions: Renal Impairment After Cardiac Surgery

Summary: the purpose of the project is to test whether or not the commonly used medication frusemide, given after heart surgery, and aiming to increase urinary output can have an effect on kidney function.

all patients will receive standard supportive care based on current established management practice of cardio-thoracic patients. the only difference in treatment will be the randomisation of patients to receive/not receive protocolised administration of frusemide targeting a urine output. there will be 2 groups of patients. the control group-which will receive frusemide bolus doses if required as determined by the surgeon/consultant physician. the frusemide infusion group-which will be monitored to achieve a trial specified hourly urine output target range of 1-2mls/kg/hour. in order to achieve this target the patient may need to receive a loading dose of frusemide and may also then require a frusemide infusion. the aim will be to maintain the urine output within the target range for the first 48 hours after cardiac surgery.

Eligibility criteria:
inclusion criteria: all patients admitted for cardiac surgery will be assessed for eligibility. participants will be approached for inclusion, from the pre-admission clinics and wards of the cardiothoracic surgery unit. potential participants will be identified by the daily review of planned cardiothoracic surgery schedule. exclusion criteria: 1. already in established dialysis dependent chronic renal failure. 2. known allergy to frusemide 3. age \< 18 years 4. pregnant
the biophysical impact of transcutaneous spinal cord stimulation within a single session

Conditions: Spinal Cord Injuries

Summary: to determine the biophysical impact of biophysical impact of transcutaneous spinal cord stimulation (tscs) within a single session. we hypothesize that subjects will demonstrate increased volitional muscle strength with tscs. this will be assessed by isokinetic strength testing of post-injury dominant-side knee extension. subjects will be tested in both transcutaneous spinal cord stimulation and sham conditions.

the investigators will conduct isokinetic strength testing (via the biodex) of post-injury, dominant-side knee extension before, during, and after tscs and a sham condition. transcutaneous spinal cord stimulation will be applied (via the vectra neo) using a 5cm x10cm oval electrode placed midline on the skin between spinous process t11 -t12 as a cathode and two 7.5cm x 13cm rectangular electrodes placed symmetrically on the skin over the lower abdomen as anodes. a symmetrical biphasic rectangular waveform, at 50hz and 1millisecond, will be used to provide 30 continuous minutes of stimulation. as sham procedures for this intervention have not been established, the investigators will follow sham procedures well documented in transcranial dc stimulation (tdcs). electrodes will be placed as they are in the transcutaneous spinal cord stimulation condition. stimulation will be applied at subject's maximum intensity for 30 seconds and then discontinued. subjects will participate in two testing sessions, each approximately one hour in length, separated by at least 24 hours. subject's starting condition will be randomized. subjects will be informed that two stimulation conditions are being tested, but will not be told which is the experimental condition.

Eligibility criteria:
inclusion criteria: * \> 1 year post spinal cord injury * non-progressive spinal cord injury * neurological level above t10 * tolerates upright position for \>30 minutes * medically stable (no hospitalizations in last 3 months) * unilateral knee extension strength \>/= 1/5 mmt * able to comply with procedures and follow up * are legally able to make their own health care decisions exclusion criteria: * progressive sci/d (ms, als, adem, etc.) * opens wounds at stimulation site * pregnant women * rom limits of \>10 degree of knee flexion or extension * cardiac pacemaker/defibrillator * active cancer diagnosis * currently receiving tscs * evidence of uncontrolled autonomic dysreflexia * non- english speaking
individual survivorship program for ovarian cancer patients based on prom's and shared decision making

Conditions: Ovarian Cancer; PROM; Quality of Life

Summary: in 2015 the danish healthcare authorities initiated major changes in the follow-up (fu) program for patients with ovarian cancer. the new fu program argues that there is no effect of routine monitoring, and every patient's fu is now individualized. these changes have caused major concern, especially regarding the omission of routine examinations aimed at detection of recurrence, since clinical symptoms of relapse can be diffuse. clearly, tools and fu plans to support the patients in feeling safe during fu are of vital importance. patient-reported outcome measures (prom) is a tool to improve the focus on patients' needs, symptoms and preferences. it is also a tool to monitor quality of life (qol), and side effects. 300 patients with ovarian cancer are planned to be enrolled after primary treatment when they enter follow-up program. this is a multi-center study. all participants fill in a questionnaire at baseline and then every 3 months for two years, and every 6 months the third year. the questionnaire consists of eortc-qlq-c30, eortc-ov28, and questions on symptoms of relapse. at baseline the questionnaire is extended with demographic issues. the patients will also fill in a brief questionnaire (collaborate) dealing with patient satisfaction and the level of shared decision making experienced. all participants are followed for 3 years.


Eligibility criteria:
inclusion criteria: * patients \>18 years of age. * histologically confirmed epithelial ovarian, fallopian tube or serous primary peritoneal cancer. * have completed their first line treatment, with complete remission. * manage to read and speak danish. * can receive active anti-cancer treatment such as maintenance bevacizumab exclusion criteria: •have recurrent disease after first line treatment.

Keywords: shared decision making follow-up
clinical validation through analytical study with urine samples to compare the effectiveness and security of an intelligent device

Conditions: Renal Insufficiency, Chronic; Heart Failure; Diabete Mellitus; Diabetes; Nephropathy (Manifestation); Hematuria; Urinary Tract Infections

Summary: the objectives of the clinical validation through analytical study with urine samples to compare the effectiveness and security of an intelligent device are: 1.to evaluate the performance of s-there device in comparison to the golden standard used in the lab.


Eligibility criteria:
inclusion criteria: * patients who came to the emergency room, primary care and nephrology unit. exclusion criteria: * subject cannot collect urine in receptacle. * urinary catheter
arteriovenous fistula maturation evaluation study. fame study

Conditions: End-stage Renal Disease; Hemodialysis Access Failure; Vascular Access Maturation; Native Arteriovenous Fistula

Summary: study of the features of hemodynamic and clinical maturation of the native arteriovenous fistula for hemodialysis.

this is a prospective, single-center, observational study, investigating the clinical and hemodynamic features of maturation of hemodialysis native arteriovenous fistula (avf). hemodynamic features under investigation are the diameter of the feeding brachial artery, volume of flow (vf) measured with transcutaneous duplex ultrasound (dus), resistivity index (ri), diameter and wall thickness of the efferent vein, measured at days 1, 2, 3, 4, 5, 6, 7, 14, 21, 30, 60 and 90 post creation. clinical features of maturation are the time of first access successful cannulation and the performance of three consecutive adequate dialysis sessions.

Eligibility criteria:
inclusion criteria: 1. hemodialysis patients 2. new native arteriovenous fistula (avf) exclusion criteria: 1. patients not eligible for avf creation 2. patients with non compensated heart failure new york heart association stages 3 and 4

Keywords: hemodialysis native arteriovenous fistula maturation feeding artery efferent vein
cognitive process of diagnostic error in emergency physicians

Conditions: Thinking

Summary: diagnostic error, dual process model of reasoning) during the last decade, much emphasis has been placed on system solutions to patient safety problems. however, diagnostic error, despite being responsible for twice as many adverse events as medication error, has received little attention. the rate of diagnostic errors have been estimated to be between 0.6% to 12%.some estimates are as high as 15%.the rate of negative outcome or adverse effects of diagnostic errors range from 6.9% to 17%. most authors accept that the dual process model of reasoning explains how clinicians make diagnoses. the purpose of this study is to investigate why diagnostic errors occurred in the emergency departments (eds).

diagnostic error, dual process model of reasoning) during the last decade, much emphasis has been placed on system solutions to patient safety problems. however, diagnostic error, despite being responsible for twice as many adverse events as medication error, has received little attention. the rate of diagnostic errors have been estimated to be between 0.6% to 12%.some estimates are as high as 15%.the rate of negative outcome or adverse effects of diagnostic errors range from 6.9% to 17%. most authors accept that the dual process model of reasoning explains how clinicians make diagnoses. the purpose of this study is to investigate why diagnostic errors occurred in the emergency departments (eds). a qualitative study approach was used with in-depth semi-structured interviews conducted with emergency physicians to investigate the cognitive diagnosis process. the study takes place in the eds of three hospitals in taiwan. we chose the participants using a purposive sampling technique to yield a sample that would be most likely contribute significant information on the diagnostic process. sampling continued until novel information was no longer being gathered. all audiotapes were transcribed verbatim. the transcripts are analyzed by two of the investigators based on the ground theory. once all relevant codes were identified, they were grouped together into meaningful categories. these categories were then grouped under appropriate themes, which were used to generate a theory of diagnostic errors.

Eligibility criteria:
inclusion criteria: * trained emergency physicians exclusion criteria: * refused interview

Keywords: diagnostic error
cams-ras: for suicide prevention

Conditions: Suicide

Summary: this phase i feasibility study endeavors to create a prototype of a tool to determine its feasibility with suicidal patients in emergency departments (eds). this is not a clinical trial. the overarching goal of this research is to create a tool that could reduce suicide rates, increase delivery of efficacious suicide interventions, and decrease overall costs associated with suicidal behaviors. sbir phase i project aims include: (1) creating an advisory board to guide the development of cams-ras; (2) iteratively design and develop relational agent ("dr. dave") modeled after the gestures, expressions, and mannerisms of cams treatment developer, david jobes, phd; and (3) conduct feasibility tests to determine whether cams-ras is acceptable, easy to use, and liked by target end-users: acutely suicidal patients admitted to hospital eds, psychiatric inpatient units, and medical floors for treatment of injuries sustained during a suicide attempt; hospital medical personnel, administrators, and other stakeholders including peer advocates; and outpatient suicidal patients, clinicians and administrators.


Eligibility criteria:
patient inclusion criteria: * english fluency * 18 years or older * receiving clinical care in a hospital or outpatient clinic for suicidality * suicidal patients currently admitted to eds, psychiatric inpatient units, and medical floors, or patient with past (last 6 months) suicidality receiving outpatient treatment patient exclusion criteria: * acutely psychotic * severely agitated (as determined by care team)

Keywords: suicidality collaborative assessment and management of suicidality technology suicide prevention suicide intervention
the effect of warming and vibration applications on pain in newborns

Conditions: Pain

Summary: this study aimed to determine the effects of warming and vibration applications on pain during heel blood collection in newborns. h1: warming application has a positive effect on pain during heel blood collection in newborns. h2: vibration application has a positive effect on pain during heel blood collection in newborns. h3: the combined application of warming and vibration during heel blood collection in newborns has a positive effect on pain.

heel blood collection is frequently used for neonatal metabolic screening and analysis of bilirubin, glucose and other biochemical/hematologic parameters. this process is both painful and stressful for the newborn. pain experience in the neonatal period can cause intense stress in the infant and cause physiopathological changes such as respiratory irregularity, impaired thermoregulation, changes in heart rhythm, changes in oxygen saturation and blood pressure. therefore, it is recommended to use evidence-based non-pharmacological methods to reduce the pain experiences of newborns and to minimize the short and long-term negative effects of pain. based on this rationale, this study was planned to evaluate the effect of non-pharmacologic methods on pain and procedure time together.

Eligibility criteria:
inclusion criteria: * newborns at 38 weeks of gestation and above * healthy newborns exclusion criteria: * newborns with any lower extremity anomalies * newborns with congenital diseases

Keywords: newborn pain vibration warming heel blood collection infant
heart rate variability in children with a functional gastrointestinal disorder

Conditions: Abdominal Pain

Summary: the current study is designed to assess relationships between anxiety/stress, autonomic nervous system balance, and electrical activity in the stomach before and after eating/drinking in children with abdominal pain.

chronic or recurrent abdominal pain in children is a very common complaint in children and adolescents, and is most often associated with the presence of a functional gastrointestinal disorder (fgid). it is likely that the clinical symptoms in fgids are the result of an interaction between biologic, psychologic, and social factors. the psychologic factor most implicated is chronic stress or anxiety. stress may influence gastrointestinal function and symptoms through altering the balance of the autonomic nervous system (ans). imbalance in the ans has potential effects on gastrointestinal mechanosensitivity, motor function (e.g. stomach emptying and accommodation), and electrical rhythms. all of these can be associated with abdominal pain. theory and early evidence from studies done with healthy adult populations suggest that ans imbalance can reduce the body's ability to respond electrically to food/water consumption. however, the relationships between chronic stress/anxiety, ans balance/imbalance, and electrical activity in the stomach before and after eating/drinking remain to be fully explored in children with fgids. the current study is a two-part pilot study designed to assess these relationships. part i involves assessment of anxiety/stress (i.e., basc parent- and self-reports) along with ans balance (i.e., heart rate variability) and electrical activity in the stomach (i.e., electrogastrography) measured in the fasting state and following a test meal. part ii involves the same assessments with rapid water loading replacing the test meal. results will be analyzed by specific fgid, as well as for the group as a whole. we expect to enroll 75 children ages 8-17 in each part, including 30 healthy controls and 45 children with an fgid. elucidating these relationships is a necessary first step in developing more effective treatments for children with recurrent abdominal pain and, ultimately, reducing the personal and societal costs of this common pain entity.

Eligibility criteria:
inclusion criteria: * ages 8 - 17 years * evaluated in abdominal pain clinic at children's mercy hospital or the gastroenterology clinic at children's mercy south for abdominal pain of at least 8 weeks duration and fulfilling symptom-based criteria for fd, ibs, or fd/ibs. exclusion criteria: * previous abdominal surgery * chronic disease requiring regular medical care (e.g. gastrointestinal diseases, diabetes mellitus, juvenile rheumatoid arthritis, cystic fibrosis, cancer). * non-english speaking note: control subjects will meet all patient inclusion/exclusion criteria except for inclusion criteria #2. control subjects will be excluded for history of abdominal pain, nausea, vomiting, diarrhea, constipation, or bloating.

Keywords: abdominal pain functional gastrointestinal disorders stress anxiety autonomic nervous system
effects of nutritional supplementation on protein and energy homeostasis in malnourished chronic hemodialysis patients

Conditions: End Stage Renal Disease

Summary: the goal of this study is to evaluate the metabolic effects of concomitant use of three consecutive doses of recombinant human growth hormone over three days and exercise during continuous nutrient infusion in chronic hemodialysis patients. we would also like to evaluate the metabolic effects of nutritional supplementation alone without the additional anabolic strategies.


Eligibility criteria:
inclusion criteria: * on hemodialysis for more than 6 months, on a thrice weekly hemodialysis program; * adequately dialyzed (kt/v \> 1.4). exclusion criteria: * patients unable to perform exercise. * pregnant women. * severe unstable underlying disease besides commonly associated with esrd. cardiac patients that are stable will be included. * patients hospitalized within the last month prior to the study. * patients with recirculation detected on the av graft. * patients receiving steroids and/or other immunosuppressive agents
comparative trial of standard versus low-dose peg-interferon plus ribavirin in the treatment of chronic hepatitis c

Conditions: Hepatitis C, Chronic

Summary: the purpose of this study is to evaluate the efficacy and safety of low-dose interferon-alfa-2b plus ribavirin compared to the standard-dose of the same combination in patients with chronic hepatitis c.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of chronic hepatitis c. must be infected with genotype 1b viruses exclusion criteria: * hemoglobin levels\<8.5g/dl, * platelet counts\<50,000/mm3, * total polymorphonuclear counts\<1000/mm3 * pregnancy, * renal dysfunction,
combined kinetic chain exercises on knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: study will be conducted at faculty of physical therapy cairo university to investigate the effect of combined kinetic chain exercises on static and dynamic hamstring and quadriceps strength in knee osteoarthritis patients

the study will be conducted at faculty of physical therapy cairo university to investigate the effect of combined kinetic chain exercises on static and dynamic hamstring and quadriceps strength ,knee pain ,function ,h/q ratio in knee osteoarthritis patients .using lafayette hand held dynamometer to measuring static strength of hamstring and quadriceps ,and free weight by brzycki formula for measuring dynamic hamstring and quadriceps strength by determining 1 repetition maximum ,and pain measured by visual analogue scale (vas) rating from (0 = no pain ) to (10= worst pain ) ,and function by western ontario and mcmaster universities osteoarthritis index questionnaire lower score indicate patient get better ,number of patients will be 34 divided into 2 groups ,each group will include 17 patient ,with 2 drop out according to sample size calculation ,each group will receive conventional tens for 20 min. and hot back for 15 min. and stretching exercises for hamstring,quadriceps,calf muscles ,while the experimental group will be increased by combined kinetic chain exercises

Eligibility criteria:
inclusion criteria: * the patients age from38 to 65 * recent radiographs confirming grade 2 and 3 (mild to moderate ) osteoarthritis * primary and secondary osteoarthritis * both gender * unilateral knee osteoarthritis * pain in the knee for most days of prior month * morning stiffness less than 30 min. in duration * patient body mass index (bmi) between 18.5 and 29.9 kg/m2 exclusion criteria: * neurological disorders * wheelchair bound * significant cognitive impairment * present systemic inflammatory arthritis * history of hip and knee arthroplasty * history of trauma or surgical arthroscopy of either knee in the last 6 months * received knee intra-articular injection within the last 3 months * under anticoagulant therapy ,recent or imminent surgery (within 3 months)

Keywords: static knee strength, dynamic knee strength combined kinetic chain exercises osteoarthritis