Kornimate/medical-research-clean huggingface dataset:
norwegian adenomyosis study i

Conditions: Adenomyosis

Summary: adenomyosis is characterized by the appearance of endometrial cells in the muscular layer of the uterus. it affects about 15-20% of the female population. the symptoms of adenomyosis are heavy menstrual bleedings and painful menstruation (dysmenorrhea) and in addition chronic pelvic pain. subfertility and infertility have been correlated with adenomyosis. parity, age and uterine abrasion increase the risk of adenomyosis. hormonal factors such as local hyperestrogenism and elevated levels of prolactin have been identified, but autoimmune and mechanical factors are also hypothesized. regarding treatment, the most effective measure is hysterectomy. as this is a very drastic measure in younger women, levonogestrel-releasing intrauterine devices, gonadotropin releasing hormone (gnrh)-analogues, danazol, uterine embolization and endometrial ablation have been tried, but studies are few in number, retrospective, and have small sample sizes. adenomyosis has so far not been subject to extensive research efforts. the pathogenesis of adenomyosis remains still unclear, there are not many satisfying treatment options and diagnostics include mostly magnetic resonance imaging (mri) and histology. the investigators designed a series of 3 studies with a broad approach in understanding adenomyosis. this is part 1. napped-1: comparison of 3d-transvaginal ultrasound with mri and histology in the diagnostic of adenomyosis

diagnosis of adenomyosis with 3d and 2d transvaginal ultrasound. prospective study of a consecutive series of 101 patients that are scheduled for hysterectomy and suffer from bleeding disorders, chronic pelvic pain, dysmenorrhea or dyspareunia. all patients will undergo transvaginal 2d- ultrasound, 3d-ultrasound and power doppler (pd)-ultrasound (tvu), magnetic resonance imaging of the pelvic organs (mri) and hysterectomy. we will investigate the specificity and sensitivity of 3d and 2d transvaginal ultrasound in the diagnosis of adenomyosis and compare data with mri and histopathology, which is the gold standard by today. in addition, we will collect anamnestic information that might point to risk factors or connections to prior obstetrical complications and medicine use. in our study the pathologist will not be blinded to our ultrasound findings, and we want to investigate if this will raise the sensitivity of histology findings of adenomyosis.

Eligibility criteria:
inclusion criteria: * premenopausal women aged 30 - 50 years old * scheduled for vaginal, abdominal or laparoscopic total hysterectomy * one or more of the following clinical symptoms: bleeding disorders (menorrhagia, irregular bleeding, hypermenorrhoea), chronic pelvic pain, dysmenorrhoea, or dyspareunia * junction zone definable exclusion criteria: * postmenopausal women, * pregnancy * gynecological cancer * gnrh analog therapy or systemic hormone therapy in the last three months prior to hysterectomy * junctional zone not identifiable

Keywords: adenomyosis dysmenorrhea chronic pelvic pain infertility sensitivity histology womens health junction zone
migrant workers' responses to the covid-19 pandemic

Conditions: Coronavirus; Trust; Misinformation

Summary: rumors circulate widely during public health crises and have deleterious consequences. in this study, we seek to document the base rates of migrant workers' rumor exposure and identify predictors of rumor hearing, sharing and belief.

rumors circulate widely during public health crises and have deleterious consequences. vulnerable populations such as migrant workers tend to lack access to accurate health information, which can put them at higher risk for receiving and spreading misinformation. in this study, we seek to document (i) the base rates of migrant workers' rumor exposure and (ii) identify predictors of rumor hearing, sharing and belief. these predictors include trust in institutions, risk perceptions, online habits and socio-demographic variables. data was taken from the covid-19 migrant health study, a cross-sectional study of male migrants employed in manual labor jobs within singapore.

Eligibility criteria:
inclusion criteria: * at least 21 years old * holds a government work permit identifying their employment status exclusion criteria: * nil

Keywords: migrant workers singapore vulnerable trust rumours resilience
peer-led self-management support in "real world" clinical and community settings

Conditions: Diabetes

Summary: this study will systematically evaluate a training program in state-of-the-art behavioral change approaches and facilitation skills for peer leaders and a peer-led diabetes self-management support program designed to be conducted in community and clinic-based settings on an ongoing basis.

in phase one we will develop and evaluate a theoretically-driven program to train peer leaders to facilitate longer-term empowerment-based interventions that, when led by health care professionals, have been associated with improved diabetes-related health and psychosocial outcomes.1-8 in phase two we will examine the impact of a sustained peer-led, empowerment-based self-management intervention on improving and maintaining diabetes-related health outcomes. we propose to develop and test the training and program simultaneously in two distinct cultural and linguistic communities with which the team already has strong working relationships and a track record of prior work: african-american (aa) adults in a community-based setting (ypsilanti, michigan) and latino adults (spanish- and english-speaking) in a clinic-based setting (southwest detroit). this will allow us to compare and contrast the translations of the training and program in these two different contexts and to better refine and understand effective methods and develop culturally tailored training and program materials in both english and spanish.

Eligibility criteria:
inclusion criteria: * the study will recruit african americans and latinos with type 2 diabetes, - at least 21 years old, and * who have a regular health care provider, and * will commit to attend the 12 session dsme program. exclusion criteria: * having physical limitations preventing participation, and * other serious health conditions (e.g., terminal cancer), * serious psychiatric illness, self-reported excessive alcohol or illicit drug use, and * serious diabetes complications (e.g., blindness) that would impede meaningful participation in the program

Keywords: peer support peer leader community health worker empowerment self-management
efficacy and safety study of vicagrel in patients with acute coronary syndrome (acs) undergoing percutaneous coronary intervention (pci)

Conditions: Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Intervention (PCI)

Summary: this is a multi-center, randomized, double-blind, double-dummy, parallel-controled, phase iii trial, aiming to evaluate the effectiveness and safety of long-term continuous administration of vicagrel capsules in acs patients undergoing pci.


Eligibility criteria:
inclusion criteria: * patients between 18 and 80 years old, with no gender restrictions. * patients diagnosed with acs and scheduled for pci, including stemi and nste-acs (ua/nstemi). * voluntarily sign the icf and be able to follow the visit arrangements specified in the protocol during the trial period. exclusion criteria: * expected survival time\<12 months; * severe liver dysfunction (non heart disease induced alt or ast\>3x uln) and cirrhosis; * pregnant or lactating women, or participants and their partners who plan to become pregnant during the trial period; * the researchers determined that other reasons were not suitable for participants in this experiment.
morphometric mri analysis of cortical sulci: development of neurodevelopmental biomarkers of bipolar disorder.

Conditions: Bipolar Disorder

Summary: given the phenotypic heterogeneity of bipolar disorder, it seems essential to propose new methodologies to improve the stratification of this pathology in order to describe more homogeneous groups of patients. in this perspective, the neurodevelopmental hypothesis of bipolar disorder seems promising. brain sulcation is an indirect marker of neurodevelopmental processes. the objective of the study is to highlight sulcal variations between a group of bipolar patients with a neurodevelopmental phenotype (nd) and a group of bipolar subjects without a nd phenotype. a sulcation marker (gpr56) will also be measured from patient blood samples. in order to carry out this project we would like to include 120 participants for a period of 12 months.


Eligibility criteria:
inclusion criteria: for the "neurodevelopmental" group : the volunteer has at least 2 of the 12 neurodevelopmental criteria for the "non-neurodevelopmental" group the volunteer does not present any of the 12 neurodevelopmental criteria list of the 12 neurodevelopmental criteria : 1. the volunteer had at birth a paternal age ≥ 40 years 2. the volunteer had at birth a maternal age ≥ 35 years 3. the volunteer was born by cesarean section 4. the volunteer had a history of perinatal infection 5. the volunteer has a history of generalized anxiety disorder that began before the age of 16 (≤ 15 years) 6. the volunteer has a history of an eating disorder that began before the age of 16 (≤ 15 years) 7. the volunteer has a history of a substance use disorder (excluding tobacco) as described in the dsm-5 prior to age 16 (≤ 15 years) 8. the volunteer has a learning disability or "dys" disorder as defined in the dsm-5 or number of repeats \> 2 9. the volunteer has a history of trauma assessed as severe by the ctq self-assessment questionnaire 10. the volunteer has symptoms suggestive of attention deficit hyperactivity disorder (wurs score \> 46) 11. the volunteer has a history of psychotic features during episodes. 12. the volunteer has an early age of onset of bipolar disorder at an age below 18 years. exclusion criteria: * serious symptomatic or unstable physiological or medical condition (including pregnancy) * history of stable or non-stable psychiatric illness, schizophrenia or any other condition that may interfere with bipolar disorder * history of comorbid autism spectrum disorder * history of severe head injury (gcs\<8 at time of injury) * neurological disorder affecting central nervous system function * moderate to severe substance use disorder (\>=4/11 as defined in the dsm-5) with the exception of tobacco use disorder * under court protection or guardianship * unable to give the volunteer informed information, or the volunteer refuses to sign the consent form * insufficient command of the french language to complete the assessments * has a contraindication to mri
attitudes towards influenza vaccinations among the healthcare workers of medical university of warsaw

Conditions: Vaccnation in HCW

Summary: the study will be conducted in the uckwum teaching hospital in warsaw between 2020 and 2022. the study group will be comprised of uckwum healthcare professionals all employees willing to participate in the study will receive an anonymous questionnaire on attitudes towards influenza vaccination . we will distribute information posters of the national programme for combating influenza as part of the educational programme. in order to increase the effectiveness of the educational campaign, we will also send information e-mails, using the internal hospital e-mail system and conduct a series of online training courses to present the latest international reports on influenza vaccinations among health care professionals \[citation abr10 \\l 1045\]. considering the fact that lack of time \[citation kus11 \\l 1045\] is the most common reason for not getting vaccinated against influenza among healthcare professionals, we will provide this group with an opportunity to receive free influenza vaccination during working hours at the uckwum hospital. information about the possibility of vaccination will be provided in the form of e-mails (mailings) to hospital employees (internal hospital e-mail system), letters of information submitted to the offices of individual departments, and information posters. the effectiveness of the educational programme will be assessed by re-administering the anonymous questionnaires after the influenza season, also by means of internal hospital e-mail system.


Eligibility criteria:
inclusion criteria: * health care worker of uck wum in warsaw exclusion criteria: * non

Keywords: medicine vaccinations among healthcare professionals ,vaccinations against influenza ,covid19 pandemic and its impact on influenza vaccination coverage
effectiveness and safety of firmagon®

Conditions: Androgen Ablative Therapy of Advanced Hormone-dependent Prostate Carcinoma

Summary: effectiveness and safety of firmagon® in androgen ablative therapy of advanced hormone-dependent prostate carcinoma. the period until prostate specific antigen (psa) progression during the firmagon® therapy is to be documented and related to the testosterone values measured in the course of therapy (if available). other clinical parameters, the patients' quality of life and the direct and indirect costs incurred by the medical care for the advanced hormone-dependent prostate carcinoma and its consequences will be evaluated. in this context the medical outcome and the life quality are defined as effectiveness and benefit value parameters. both the effectiveness under daily life circumstances and economic variables of the therapy can thus be shown and compared within an analysis of costs vs. benefits or costs vs. effectiveness.


Eligibility criteria:
inclusion criteria: * therapeutic need according to spc * written informed consent exclusion criteria: - contraindications according to spc
study to evaluate the impact of using wearable devices in addition to standard clinical practice on parkinson´s subject symptoms management

Conditions: Parkinson´s Disease

Summary: evaluate the benefits of kinesia-360™ wearable technology in addition to standard clinical practice on improving parkinson´s disease motor symptoms, neupro dosing regimen and adherence to neupro compared with only standard clinical practice.


Eligibility criteria:
inclusion criteria: * subject is newly prescribed neupro and is expected to commence neupro treatment. historical neupro treatment is permitted * informed consent form (icf) is signed and dated by the subject, before any study-related procedures * subject is considered reliable and capable of adhering to the protocol, visit schedule, completion of the diary, and using kinesia devices according to the judgment of the investigator * male or female subject, \>=18 years of age at the time of the screening visit * subject has parkinson's disease, defined by the cardinal sign, bradykinesia, plus the presence of at least 1 of the following: tremor at rest, rigidity or impairment of postural reflexes, and without any other known or suspected cause of secondary parkinsonism * subject experiences motor symptoms associated with parkinson's disease that are not sufficiently controlled by current therapy. the average of the triplicate resting tremor scores and triplicate finger tapping scores from kinesia-one™ (6 scores in total) must be \>1.0 exclusion criteria: * subject is currently participating in any study with an investigational medicinal product or investigational device * subject has any medical, neurological or psychiatric condition which, in the opinion of the investigator, could jeopardize or would compromise the subject's ability to participate in this study * subject with deep brain stimulation (dbs) device implant

Keywords: parkinson´s disease kinesia-360™ kinesia-one™ biosensor
a prospective evaluation of radiofrequency ablation in the treatment of relapsed graves' disease.

Conditions: Relapsed Graves' Disease; Thyroid; Functional Disturbance; Radiofrequency Ablation Treatment

Summary: there have been previous reports of using high-intensity focused ultrasound (hifu) as a feasible thermal ablative treatment for relapsed graves' disease. in recent years, radiofrequency ablation (rfa) has become another promising alternative for thermal ablation of benign thyroid nodules. rfa has the advantage of avoiding a surgical scar, organ preservation and being an ambulatory procedure. it utilizes a small caliber radiofrequency electrode, which is inserted into the thyroid gland percutaneously. the active tip of the rf electrode would induce frictional heat in the surrounding tissue, causing a thermal ablative effect. the direct application of energy of rfa to tissue is different from that in hifu, in which energy is transmitted through the skin of the participants from the transducer. studies of follow-up after rfa of graves' disease have not been published. given the previous successful experience with hifu, the investigators would like to explore the feasibility, safety and efficacy of rfa as an alternative thermal ablation option for relapsed graves' disease. thus, the purpose of this prospective study is to assess the efficacy and safety of us-guided rfa for the treatment of relapsed graves' disease.


Eligibility criteria:
inclusion criteria: * (a) age older than 18 years, * (b) relapsed graves' disease despite an adequate atd treatment for 18 months or more and * (c) absence of vocal cord immobility. exclusion criteria: * (a) patients who prefer or indicated for surgery, * (b) head and/or neck disease preventing hyperextension of the neck, * (c) history of thyroid cancer or other malignant tumors in the neck region, * (d) history of neck irradiation, * (e) moderate to severe graves' ophthalmopatty, * (f) large compressive goiter * (g) pregnancy or lactation, and * (h) any contraindication related to intravenous moderate sedation.
safety and efficacy of agn 203818 in patients with painful diabetic peripheral neuropathy

Conditions: Diabetic Neuropathy, Painful

Summary: this study will explore the safety and effectiveness of different doses of agn 203818 in treating pain in patients with painful diabetic peripheral neuropathy


Eligibility criteria:
inclusion criteria: * diagnosis of diabetic peripheral neuropathy * moderate to severe neuropathic pain exclusion criteria: * any other uncontrolled disease * pregnant or nursing females
continuous clopidogrel dose adjustment in acute coronary syndrome patients with high on-treatment platelet reactivity

Conditions: Acute Coronary Syndrome

Summary: the purpose of this study is to determine whether continuous clopidogrel dose adjustment targeted after platelet function testing improves outcomes during 12 months of follow-up in acute coronary syndrome patients treated with coronary artery stenting and with determined high platelet reactivity on clopidogrel.

dual antiplatelet therapy (dapt) with aspirin and p2y12 receptor antagonists during 12 months presents cornerstone treatment in acute coronary syndrome (acs) patients undergoing percutaneous coronary intervention (pci). clopidogrel is the most widely used p2y12 inhibitor despite it's limitations that include highly variable p2y12-receptor inhibition which causes wide interindividual platelet reactivity variability. since high on-treatment platelet reactivity (htpr) on clopidogrel is strongly associated with adverse events, antiplatelet therapy tailoring has been vastly investigated to determine whether individualized approach could improve outcomes. in the time of progressive personalized approach to therapy, effective strategies are needed to minimize the risk of ischemic adverse events without increasing the risk for bleeding. aim of this study is to investigate whether continuous clopidogrel dose adjustment according to platelet function testing (pft) using multiplate® function analyzer (roche diagnostics, mannheim, germany) could decrease the rate of adverse events in acs patients treated with pci and with htpr during early and late period of dapt treatment. cut off values for htpr and enhanced platelet response were set according to the consensus statement at \>46 u and \<19 u, respectively. pft and therapy tailoring was performed at day 1, 2, 3, 7, 30 and month 2, 3, 6, 9 and 12.

Eligibility criteria:
inclusion criteria: * acute coronary syndrome patients treated with successful pci * age 18-80 years * determined high on-treatment platelet reactivity exclusion criteria: * continuous postinterventional glycoprotein (gp) iibiiia receptor inhibitor infusion * thrombocytopenia (\<150x109/l) * significant renal insufficiency (creatinine\>200 µmol/l) * anemia (htc\<30%) * hemorrhagic diathesis * history of intracranial bleeding or ischemic cerebrovascular insult 6 months before * major operation 6 weeks before * concomitant chronic anticoagulation therapy * age \ 80 years

Keywords: clopidogrel platelet reactivity acute coronary syndrome tailoring therapy outcome
effect of total sleep deprivation on vascular function

Conditions: Sleep Deprivation

Summary: insufficient sleep is associated with an increased risk for cardiovascular disease. the causal mechanisms are currently unknown, but may include endothelial dysfunction. the purpose of this study is to examine the influence of sex and aging on the effects of total sleep deprivation on vascular function and whether exercise training attenuates these effects.


Eligibility criteria:
inclusion criteria: * males and females * 20 to 30 and 50 to 60 years of age * females will be eumenorrheic at enrollment or postmenopausal for at least 1 year * no major clinical disease (e.g., diabetes, cardiovascular, liver or chronic kidney disease) to minimize confounding of vascular measures * participants will be sedentary (≤3x per week of ≤30 minutes of aerobic exercise/session) or trained (≥5x per week of moderate/vigorous aerobic exercise training) exclusion criteria: * age \ 60 years * body mass index ≥30 kg/m\^2 because obesity may affect vascular function * use of medication that may affect vascular measures * hormone replacement therapy or hormonal contraceptives within past year * use of tobacco products (chewing tobacco, traditional or e-cigarettes) because they may influence vascular function * being perimenopausal, pregnant or lactating because may influence vascular function * being a shift worker because habitual sleep deprivation and altered circadian rhythm may influence vascular function. * not having an "intermediate" chronotype based on the morningness-eveningness questionnaire (meq; score \ 69) because this would influence the effect of overnight sleep deprivation on vascular function. * sleep complaints based on the pittsburgh sleep quality index (psqi; score \>5) because this would influence the effect of overnight sleep deprivation on vascular function.