Kornimate/medical-research-clean huggingface dataset:
comparing two treatments for ovarian cancer: standard chemotherapy plus enzastaurin, or placebo ("sugar pill")

Conditions: Ovarian Cancer; Fallopian Tube Neoplasms; Peritoneal Neoplasm

Summary: participants with ovarian cancer usually get the drugs carboplatin and paclitaxel as initial treatment. in many participants the tumor will shrink, or even disappear, after treatment with these drugs. but, unfortunately, the tumor will grow again in many participants. this trial will try to address the question: can we delay the time till the tumor grows again by adding a 3rd drug to the standard therapy? to answer this question, participants will, by chance, either get the experimental drug enzastaurin or a "dummy pill" (placebo) during the chemotherapy and for up to 3 years after chemotherapy. participants and physicians will not know if a participant gets enzastaurin or placebo (double-blinded trial). after a predefined time, the treatment will be uncovered, and the number of participants with tumor growth at a specific time point will be compared between the two treatments.


Eligibility criteria:
inclusion criteria: * participants must have specific stages of disease, known as fédération internationale de gynécologie et d'obstétrique (figo) stages iib, iic, iii or iv * organ functions (blood, renal, liver, cardiac) must meet specific requirements. * participants who could become pregnant must take care not to become pregnant during the study participation and for 6 months after study discontinuation * participants must give written consent for study participation. exclusion criteria: * participants received any experimental drug within the last 30 days. * participants received any prior chemotherapy or other drug therapy for the current disease. * participants receive any other treatment for the cancer during study participation. * participants are unable to discontinue concurrent administration of carbamazepine, phenobarbital, or phenytoin. * participants are pregnant, breast feeding, or not using adequate contraceptive methods to prevent pregnancy.
comparison of pr efficiency in home-based with hospital-based pr in bronchiectasis

Conditions: Bronchiectasis; Pulmonary Rehabilitation; Lung Diseases; Lung Diseases, Interstitial

Summary: the investigators aimed to compare the home-based pulmonary rehabilitation with the hospital-based pulmonary rehabilitation in terms of pulmonary rehabilitation efficiency in patient with bronchiectasis.

while the benefits of pulmonary rehabilitation (pr) in cases of chronic obstructive pulmonary disease (copd) have been well-documented, there have been only a limited number of studies investigating the efficacy of pr in patients with bronchiectasis. some of these studies have reported positive effects of pr also in bronchiectasis patients, but have underlined the need for additional studies including larger patient groups to define pr indications, and to ensure that exercise protocols are specific for this patient group. there are many pr organizational types, such as hospital-based, telephone-mentoring with home-based or tele monitorization programs. hospital-based supervised programs are time-consuming and costly practices. for this reason, there is a need for further studies on the effectiveness and benefits of unsupervised programs. in this study, we will compare unsupervised home-based pr and supervised hospital-based pr in terms of pulmonary rehabilitation effectiveness. the pulmonary function tests, dyspnea perception, quality of life and exercise capacity assessments will performed before and after pulmonary rehabilitation.

Eligibility criteria:
inclusion criteria: * between the ages of 18-70 * patients signing informed consent form * bronchiectasis patients in the stable phase who were diagnosed with high-resolution computed tomography (hrct). exclusion criteria: * decompensated heart failure, uncontrolled hypertension (systolic blood pressure\> 200, diastolic blood pressure\> 110), * additional diseases that may prevent exercise, * to be regularly exercising regularly
vdr and tfip11 gene polymorphism and gene-environmental interaction in adults

Conditions: Low Caries Experience; High Caries Experience

Summary: vdr and tfip11 gene polymorphism and gene-environment interactions on caries etiology and susceptibility in adults.

to date, genes can be grouped into categories based on the factor influencing dental caries. the major candidate gene categories to date include enamel formation genes, immune response genes, genes related to saliva, and genes related to taste and dietary habits. tfip11 and vdr genes are related to enamel formation genes

Eligibility criteria:
inclusion criteria: * adult be between 24 and 40 years old * subject has dmft (decayed, missing, filled, permanent tooth) dmft≤4 , or, dmft\>13.9 exclusion criteria: * systemic or genetic disorders * orthodontic appliances * pregnant women

Keywords: caries experience, vdr, tfip11, enviromental risk factor
hemodynamic effects of impella on renal circulation and risk of ca-aki among patients undergoing protected pci

Conditions: Contrast-induced Acute Kidney Injury (CI-AKI)

Summary: patients undergoing percutaneous coronary intervention (pci) are exposed to the risk of suffering from a damage to the kidneys which goes under the name of contrast-associated acute kidney injury (ca-aki), which is more common if the subject has advanced heart or kidney disease. up to 1 high risk patient in 3 can suffer from ca-aki. impella is a pump which sustain the heart in the course of pci in high risk individuals. incidentally, impella was shown to also reduce the incidence of ca-aki. the reason why impella protects the kidneys is not currently known. the investigators aim at understanding it through measurements of kidney blood flow and metabolism.

contrast-associated acute kidney injury (ca-aki) is among the major determinants of morbidity after percutaneous coronary intervention (pci). patients undergoing complex, high-risk indicated procedures (chip) are exposed to an increased risk of ca-aki. recent observational data suggested that mechanical circulatory support (mcs) with impella in the course of chip pci, i.e. impella-protected pci, may abate the risk of ca-aki. a direct effect of mcs in improving renal perfusion has been postulated, but mechanistic evidence on the pathophysiologic effects of impella on kidney hemodynamics is lacking. the investigators hypothesize that such improved renal outcomes during impella protected pci are attributable to increased blood flow as well as increased oxygen delivery to the kidneys granted by mcs. the aim of the present study is to fully characterize the renal hemodynamics as well as renal oxygen delivery and consumption during impella-protected pci using state-of-the-art invasive measurements, and to correlate those with functional magnetic resonance imaging of the kidney.

Eligibility criteria:
inclusion criteria: impella-protected pci selection criteria according to virginia commonwealth university (vcu) complex pci program * left ventricular ejection fraction (lvef) ≤35% and ≥1 complexity feature * lvef ≤45% and estimated glomerular filtration rate (egfr) \<30 ml/min/1.73 m2 and ≥1 complexity feature * lvef ≤45% and egfr 31-45 ml/min/1.73 m2 and ≥2 complexity features complexity features * planned treatment of ≥2 vessels * left main pci * bifurcation intervention with 2-stent strategy * planned use of atherectomy (rotational, orbital, laser) * chronic total occlusion pci * pci on last remaining vessel * lvedp \>18 mmhg * cardiac index \<2.0 l/min/m2 or pulmonary artery o2 saturation \<55% exclusion criteria:- * pregnancy or lactation * presence of non-mri compatible implanted medical device * known absolute contraindication to impella insertion, e.g. severe peripheral arterial disease, left ventricular thrombus, aortic mechanical prosthesis, or severe aortic valve stenosis * chronic hemodialysis before the index procedure * status post-renal transplant * prisoners
study in healthy recreational polydrug users to measure the abuse potential of tc-5214

Conditions: Drug Abuse; Healthy

Summary: this is a single dose, crossover study to assess the abuse potential of tc-5214 compared to placebo, ketamine, and phentermine in healthy recreational polydrug users.

a single-center, single-dose, double-blind, randomized, placebo- and active-controlled crossover study to evaluate the abuse potential of tc-5214 in healthy recreational polydrug users.

Eligibility criteria:
inclusion criteria: * current recreational polydrug users with experience with at least 2 drug classes of abuse. * at least 10 lifetime uses of stimulants drugs (eg, amphetamine, cocaine, methamphetamine) and 10 lifetime occasions of recreational use of psychedelic drugs (eg, cannabis, ketamine, dextromethorphan, pcp, mdma \[ecstasy\], lsd, mesacline, or psilocybin). * recreational use of other classes of drugs is permitted, including opioids (eg, codeine, morphine, or heroin), minor tranquilizers, or sedatives (eg, benzodiazepines or barbiturates). * male or female volunteers aged 18 to 55, inclusive with a body mass index (bmi) within the range of 19.0 to 33.0 kg/m2, inclusive, and a minimum weight of 50.0 kg at screening. * must pass qualification phase eligibility criteria. exclusion criteria: * self-reported history of drug or alcohol dependence (except caffeine) in the past 12 months, including subjects who have ever been in a drug rehabilitation program (other than treatment for smoking cessation). * unwillingness or inability to abstain from recreational drug use for the duration of the study from screening until follow-up. * positive for hepatitis b, hepatitis c, or human immunodeficiency virus (hiv) at screening. * any significant unstable hepatic, renal, pulmonary, cardiovascular, ophthalmologic, neurologic, or any other medical conditions that might confound the study or put the volunteer at greater risk during study participation. * currently smoking more than 20 cigarettes (or 2 cigars) per day, and/or unwillingness to abstain from smoking for durations of at least 12 hours. * use of tobacco cessation product within 1 month (eg, nicotine substitution products, bupropion, etc).

Keywords: phase i healthy recreational polydrug users abuse liability tc-5214 single dose crossover study to evaluate the abuse potential of tc-5214
open-label study to investigate the safety, tolerability, pk, and pharmacodynamics of the akt inhibitor gsk690693

Conditions: Cancer

Summary: this study is a first time in human, phase i, open-label study to determine recommended doses and schedules, based on maximum tolerated doses and biologically active doses, for the akt inhibitor gsk690693.


Eligibility criteria:
inclusion criteria: * confirmed diagnosis of solid tumor malignancy or lymphoma that is not responsive to standard therapies or for which there is no approved therapy * female patients of child-bearing potential must be willing to abstain from intercourse from 2 weeks prior to administration of the first dose of study medication until 28 days after the final dose of study medication or be willing to consistently and correctly use an acceptable method of birth control. exclusion criteria: * prior anti-cancer therapy within the prior 28 days. * history of diabetes. * coronary artery disease/myocardial infarction, acute coronary syndromes within the past 6 months. * use of theophylline and warfarin within 14 days prior to the first dose of study drug. * current use of oral corticosteroids (note: inhaled corticosteroids are permitted.) * participation in an investigational study within the prior 28 days. * pregnant or breast-feeding.

Keywords: gsk690693, solid tumors, lymphoma, akt
immediate and longterm effects of mulligan mobilization with and without myofascial release on pain,grip strength and function in patients with lateral epicondylitis

Conditions: Lateral Epicondylitis

Summary: this study will help to determine the immediate and long term effects of mulligan mobilization with and without myofascial release on pain, grip strength and function in patients with lateral epicondylitis

tennis elbow patients usually experience diminished grip strength, decreased functional activities, and increased pain, all of which can have a significant impact on everyday activities. tennis elbow can also be caused by excessive elbow use. the following is a description of the basic clinical manifestation of tennis elbow, as well as the most commonly reported symptoms of people suffering from the condition: tennis elbow is easily identified and confirmed with a test that produces discomfort, palpable tenderness over the lateral epicondyle facet, resisted wrist extension, resisted middle finger extension, and passive wrist flexion. tennis elbow is a common elbow disease caused by excessive use. furthermore, despite some difficulty, the patient must be able to extend his or her wrist and middle finger. the goal of this study is to find out how mulligan mobilization with and without myofascial release affects pain, grip strength, and function in people with lateral epicondylitis in the short and long term. mulligan mobilisation and myofascial release have both been shown to be effective treatments for lateral epicondylitis. the purpose of this study is to look into the short-and long-term advantages of myofascial release and mulligan mobilisation. no research has been conducted to evaluate whether mulligan mobilisation with or without myofascial release benefits people with lateral epicondylitis in terms of pain, grip strength, and overall function. this study will not only help therapists come up with treatment goals for lateral epicondylitis, also known as tennis elbow, but it will also add credibility to the existing body of literature.

Eligibility criteria:
inclusion criteria: 1. age group 20 years to 40 years ,both males and females 2. diagnosed cases of lateral epicondylitis by senior physiotherapist 3. acute and sub-acute cases 4. numeric pain rating scale 4 and above 5. positive cozen test, mills test, middle finger extension test exclusion criteria: * h/o 1. active medications. 2. dermatitis, malignancy or hazardous to myofascial release. 3. recent trauma, fracture 4. prior surgeries of elbow, tendon ruptures 5. any neurological conditions like nerve compression 6. swelling around the elbow joint
development of normative ultrasound databases of tongue surface configuration

Conditions: Healthy; Speech Disorders

Summary: our past ultrasound research has indicated a need for baseline normative tongue data against which to compare our disordered speech populations. subjects with normal speech and hearing who represent different ages and sexes, will be studied with respect to tongue shape and movement patterns. recently developed parameters such as curve fitting, curve averaging, and polar coordinates will be used to create baseline data categories. in addition, new parameters and improved instruments will be developed as previously to produce a data base which can be used across disciplines.

our past ultrasound research has indicated a need for baseline normative tongue data against which to compare our disordered speech populations. subjects with normal speech and hearing who represent different ages and sexes, will be studied with respect to tongue shape and movement patterns. recently developed parameters such as curve fitting, curve averaging, and polar coordinates will be used to create baseline data categories. in addition, new parameters and improved instruments will be developed as previously to produce a data base which can be used across disciplines.

Eligibility criteria:
healthy normal subjects. no reconstructive tongue surgery. no radiation for head and neck malignancy.

Keywords: baseline data curve averaging curve fitting movement patterns normative data polar distribution tongue tongue shape ultrasound
target therapies resistance molecular profiling in patients with neoplastic disease

Conditions: Solid Tumors

Summary: the main purpose of this study is to define the molecular profile of selected solid tumors. from each participants will be collected biological materials for molecular analysis, including saliva, blood and vital tumor tissue derived form surgical or biopsy procedures. whereas possible, vital tumor specimens will be inoculated and propagated in immunocompromised nod/scid mice to study the genetic correlations between genetic status and response to target drugs.


Eligibility criteria:
inclusion criteria: patients with at least one of the following selected solid tumors: * colorectal cancer (primary or with synchronous/metachronous liver metastases) * prostate cancer * head \& neck tumors * gastric cancer * glioblastoma * breast cancer * hepatocarcinoma * biliary tract carcinoma * lung cancer (primary) * rare tumors (incidence ≤ 5x10-6) * metastatic sarcoma * metastatic melanoma exclusion criteria: -
eti during intubation

Conditions: Intubation; Cardiac Arrest

Summary: the objective of this study is to compared effectiveness of intubation using etview vivasight sl and standard tracheal tube during resuscitation performed by a novice-physicians.


Eligibility criteria:
inclusion criteria: * give voluntary consent to participate in the study * maximum 1 year of work experience in medicine * maximum 10 clinical intubations exclusion criteria: * not meet the above criteria * wrist or low back diseases
a randomized control trial comparing linjeta versus humalog in pumps: effect on postprandial blood sugars.

Conditions: Diabetes Mellitus

Summary: the purpose of this study is to determine if the use of linjeta(tm) insulin when compared to humalog will result in significantly lower episodes of hyperglycemia and hypoglycemia after a breakfast meal.


Eligibility criteria:
inclusion criteria:1)type 1 diabetes for at least 1 year 1. the diagnosis of type 1 diabetes is based on the investigator¡-s judgment; c peptide level and antibody determinations are not needed. 2) age : 18 years old ¨c 49.99 years old 3) continuous subcutaneous insulin infusion (csii) therapy for at least 3 months 4) participant consent demonstrated by signing irb approved documents 6) hga1c ¡ü 9% 7) if participant is female with reproductive potential, willing to avoid pregnancy and pregnancy test negative. exclusion criteria:1) chronic oral steroid use 2) the presence of a significant medical disorder that in the judgment of the investigator will affect the wearing of sensors or the completion of any aspect of the protocol. 3) known clinical history of celiac disease or inflammatory bowel disease. 4) participants will have a negative anti-endomysial antibody or anti-tissue transglutaminase antibody within one year of enrollment. 5) cystic fibrosis 6) inpatient psychiatric treatment in the past 6 months. 7) currently pregnant or lactating, or anticipate getting pregnant in the next one year. 8) clinical diagnosis of gastroparesis. 9) insulin binding capacity greater than 10 microunits per litter
effects of a health intervention on hypoglycemic coping : a pilot study

Conditions: Type 2 Diabetes Mellitus; Hypoglycemia; Health Education

Summary: from august 2023 to january 2024, 100 patients with type 2 diabetes who met the inclusion and exclusion criteria were selected from the endocrinology department of the purpose of this study was to construct a hypoglycemia coping intervention program for type 2 diabetic patients based on the imb theory and to investigate the feasibility, acceptability, and initial effects of the program.

in this study, eligible participants were randomized in a 1:1 ratio into an intervention group (health education based on imb theory given on top of regular diabetes health education) and a control group (regular diabetes health education), with a 4-week intervention period and a 8-week follow-up period, for a total of 12 weeks.

Eligibility criteria:
inclusion criteria: * patients who meet the 2018 ada medical standards for diabetes diagnosis and treatment, are diagnosed with t2dm and use insulin or sulfonylurea drugs; * duration of diabetes mellitus ≥1 year * age ≥18 years old; * a history of hypoglycemia in the past 6 months; * type 2 diabetes patients with hypoglycemia coping style questionnaire inclination, avoidance, compromise; * good communication and language skills; * have a smartphone and can use it; * voluntary participation in this study. exclusion criteria: * patients with type 1 diabetes; * patients with type 2 diabetes combined with serious complications; * patients who have recently or are participating in other similar studies.

Keywords: type 2 diabetes mellitus hypoglycemic coping style imb theory
observational study of musculoskeletal patients in an emergency department in france

Conditions: Musculoskeletal Pain

Summary: the purpose of this study is to estimate the number of patients who come to the emergency department with a musculoskeletal referral, to describe the different types of diagnosis for these patients and their treatment and discharge.

there is a crisis in the emergency department (ed) in france, as their number of consultations have constantly increased over the past ten years . musculoskeletal disorders (msk) are the most common cause of consultations in ed, as an example there is an average of 30% of ed consultations being for traumatic issues . moreover, 90% of all patients coming in ed in france have a favourable prognosis of evolution (no risk of seriousness). in this situation, one of the propositions to help to reduce the ed burden is to allow a direct access to physiotherapists. they are the recommended profession to treat patients for musculoskeletal conditions and several studies showed physiotherapy assessment and treatment in an emergency service is safe and beneficial both for the patients and the hospital teams. they have reported to increase satisfaction, to reduce medications and requirement for expensive imaging on one hand, and to reduce the costs and to give more time to the medical team on the other hand this role does not exist yet in france, although more than 48 countries across the world have implemented it, and french physiotherapists are advocating for it. a recent text has been adopted by the french government allowing patients with recent ankle sprain or low back pain to self-refer to physiotherapists working in hospitals or in care home. . however, this access is very restricted, which will make the implementation difficult as it might not be sufficient to assist the ed. moreover, there is a lack of information on the number and the type of diagnostic of patients with a msk label coming to the ed, which makes it difficult to assess the impact this role could have on french ed. in this context, a retrospective survey, describing how many patients with a musculoskeletal label are coming to the ed, and how they are managed, could help to estimate the worthiness of physiotherapist direct access in french ed. question : what is the proportion, the type of diagnostic and the management of musculoskeletal disorder in emergency department in one hospital in france?

Eligibility criteria:
inclusion criteria : * patients aged between 18 and 68 * patients admitted to emergency with a triage by the reception and referral nurse of 0, 1 or 2 * patients who consulted for one of the following reasons: lower limb pain (t13.9) lower limb trauma (m79.61) upper limb pain (t11.9) upper limb trauma (m79.60) spinal pain (m54.9) lumbar or flank pain (r10.3) diffuse/unspecific pain (r52.9) loss of sensitivity/paraesthesia - patients informed of the study and who did not object exclusion criteria : * patients with another reason for consultation associated with the first * patients under guardianship / curatorship and patients under safeguard of justice.

Keywords: emergency department musculoskeletal disorder