Kornimate/medical-research-clean huggingface dataset:
cognitive outcomes of brain stimulation as a later-in-life treatment

Conditions: Mild Cognitive Impairment; Dementia; Amnestic Mild Cognitive Impairment - aMCI

Summary: this is a pilot study being done to attempt to improve episodic memory problems in persons with mild cognitive impairment (mci) or dementia. the pre-supplemental motor area (presma) and dorsal anterior cingulate cortex (dacc) have been shown to play a role in episodic memory and language retrieval. prior studies have suggested that neurostimulation targeting this region can improve episodic memory and word recall. the purpose of this study is to examine the efficacy of high-definition transcranial direct current stimulation (hd-tdcs) to the presma/dacc region and its influence on word retrieval and other cognitive functions in patients with mci or dementia. entraining the presma/dacc circuit with 10 sessions of hd-tdcs will allow us to study whether neurostimulation may be an effective treatment.

the research objective of this study is to examine the efficacy of hd-tdcs to the presma/dacc region and its influence on word retrieval and other cognitive functions in patients with mci or dementia after 10 sessions of hd-tdcs. there will be two treatment arms: active hd-tdcs (1 ma) and a sham group. for phase 1, participants will receive 10 sessions of active stimulation (1 ma anodal hd-tdcs targeting presma/dacc for 20 min) or sham across 2 weeks. word retrieval and other cognitive tasks will be completed at baseline, immediate follow-up after session 10, and a 2-month follow-up. for phase 2, participants randomized into the sham group will have the opportunity to return after 2 months and receive the active treatment while being unblinded to their treatment condition. following 10 active treatment sessions, word retrieval and other cognitive tasks will again be completed immediately following the last hd-tdcs session and then a 2-month follow-up.

Eligibility criteria:
inclusion criteria: active diagnosis of mild cognitive impairment or dementia, female and male subjects, all races/ethnicities, age 55 years and older, fluent in english, exclusion criteria: lifetime history of major neurologic syndromes (e.g., epilepsy, brain tumor, etc), substance use disorder within the past year, has metal fragments in skull/head, current vision or hearing impairment that interferes with testing, current medication use known to alter hd-tdcs reactivity
prevail-20j - transfemoral placement of 20mm aortic balloon expandable transcatheter valve trial

Conditions: Aortic Valve Stenosis

Summary: a single arm, prospective multicenter non-randomized pivotal clinical trial evaluating the 20mm edwards sapien xt™ transcatheter heart valve (model 9300tfx), novaflex™ transfemoral delivery system, and crimper accessories. the trial includes a premarket pivotal cohort to evaluate the system performance as well as a post market clinical follow-up phase involving long term follow-up of all patients to evaluate the safety of investigational devices up to 5 years.

purpose: to evaluate the safety and efficacy of thv-9300 (20mm) for patients who have severe symptomatic aortic stenosis attributed to calcification and degeneration of a valve leaflet and for whom undergoing a surgery safely would be difficult. enrollment: 15 patients (no.of patients needed: 12) follow-up: subject data collection will include clinical information at baseline and during the index procedure. subjects will undergo clinical follow-up at discharge, 30 days, 6 months and annually for 5 years. clinical sites: 1)osaka university hospital, 2)kurashiki central hospital, 3)sakakibara heart institute, 4) kokura memorial hospital

Eligibility criteria:
inclusion criteria: * patients who were judged difficult to safely undergo avr * severe senile degenerative aortic valve stenosis * nyha functional class ii or greater * signed informed consent exclusion criteria: * aortic valve is congenital unicuspid or bicuspid * annulus size between \ 19 mm * lvef \< 20 %

Keywords: sapien xt valve (20mm) cardiovascular disease valvular heart disease aortic stenosis heart valve therapy transcatheter transfemoral efficacy endpoints indexed aortic valve area nyha
rosuvastatin pre-treatment influences the risk of coronary intervention study

Conditions: Coronary Artery Disease

Summary: the aim of this study is to determine whether a pre-treatment with high-dose statin (one day prior and just before intervention, rosuvastatin 20mg/day) has a positive impact on the occurrence of periprocedural myocardial infarction during percutaneous coronary intervention (pci).

the aim of this study is to attest whether a short-term treatment with high-dose statin (one day prior and before intervention, rosuvastatin 20mg/day) can have a positive impact over the occurrence of periprocedural myocardial infarction during percutaneous coronary intervention (pci). patients with stable or unstable (with negative troponin) angina pectoris receiving statins (or not, except rosuvastatin 40mg a day) therapy referred for coronary angiography and subsequently pci will be enrolled and randomized (ratio 1:1) to pre-treatment with rosuvastatin (20mg 12 hours prior + 20mg immediately before pci - rosuvastatin group), or immediate pci (control group). serum concentration of troponin i will be measured prior to, 12 hours and 24 hours after pci. power of study (200 vs 200 pts; p1 = 0.2; p2 = 0.33; alfa = 0.05, n1 = 200, n2 = 200; power 0.84). the primary end-point will be the tni concentration ≥ 1.5 times the uln. the secondary end-point witl be the tni concentration ≥ 3 times uln. the cox regression model will be used to identify the predictors of primary end-points (age, diabetes, smoking, symptomatic peripheral artery disease, statin pre-treatment, level of total cholesterol, pre-treatment with clopidogrel, multi-vessel disease, unstable angina, hs-crp, therapy with beta-blockers, treatment of complex coronary lesion). the patient included shall fulfill all the criteria: 1) significant coronary artery stenosis or occlusion indicated for percutaneous coronary intervention and 2) signed informed consent. the criteria excluding the inclusion in the study are: 1) positive troponin i (≥ 1 uln), 2) previous inclusion in this study, 3) renal insufficiency, 4) chronic treatment with rosuvastatin 40mg or more, and 5) disagreement to be included in this study. this study will be multicenter. the motol university hospital will participate as the project coordinator.

Eligibility criteria:
inclusion criteria: * significant coronary artery stenosis or occlusion indicated for percutaneous coronary intervention * signed informed consent exclusion criteria: * positive troponin i (≥ 1 uln) * previous inclusion in this study * renal insufficiency (creatinine ≥ 200 umol/l) * chronic treatment with rosuvastatin 40mg or more

Keywords: coronary artery disease percutaneous coronary intervention statins periprocedural myocardial infarction
immediate effects of kinesio taping in primary dysmenorrhea

Conditions: Primary Dysmenorrhea

Summary: primary dysmenorrhea is characterized by recurrent, cramping lower abdominal pain during menstruation and affects approximately 50% to 90% of women. the etiology of primary dysmenorrhea involves the increased release of prostaglandins and other inflammatory mediators, which cause uterine contractions and reduced blood flow. in addition to pharmacological approaches, non-pharmacological methods also play an important role in the treatment of dysmenorrhea. kinesio taping helps relieve pain by reducing pressure on the muscle and supports treatment through various application techniques. it improves local circulation, reduces muscle tension, and alleviates symptoms of primary dysmenorrhea. the aim of this study is to investigate the effects of kinesio taping on pain, menstrual symptoms, fear of movement, and sleep quality in women with primary dysmenorrhea, and to compare the outcomes with those of a sham taping group. the hypothesis is that kinesio taping will be more effective than sham taping in improving these parameters in women with primary dysmenorrhea.


Eligibility criteria:
inclusion criteria: * being a nulliparous woman aged between 18 and 24 years * having a diagnosis of primary dysmenorrhea confirmed by a physician, * being literate * cooperating in completing the assessment scales * scoring one or above on the weissman scale * agreeing to participate in the study * having regular menstruation in the last 6 months * being willing and voluntary to participate in the research. exclusion criteria: * having a diagnosis of secondary dysmenorrhea * using contraceptive pills * having a history of childbirth or pregnancy * having irregular menstrual cycles (menstrual cycle length less than 21 days or longer than 35 days) * having any pelvic pathology or history of pelvic surgery * having gastrointestinal, urogynecological, autoimmune, psychiatric, neurological diseases, or other chronic pain syndromes.

Keywords: kinesio taping pain menstrual symptoms fear of movement sleep quality
african youth in mind (y-mind) - pilot feasibility trial of a brief psychological intervention for young people with depression in zimbabwe

Conditions: Depression

Summary: the overarching aim of this single-arm pilot study is to assess the feasibility of implementing a psychological intervention (y-mind), delivered by lay counsellors, for the treatment of depression among young people aged 15-24 in in harare province, zimbabwe. the study aims to assess the feasibility, acceptability and fidelity of delivering the six-session y-mind intervention, and collect preliminary clinical outcomes for depression at 5-month follow up.

the overarching aim of this single-arm pilot study is to assess the feasibility of implementing a psychological intervention (y-mind) for the treatment of depression among young people aged 15-24 in in harare province, zimbabwe. the six session problem solving therapy intervention will be delivered by trained and supervised lay counsellors. 50 young people will be recruited aged 15-24 through primary care clinics to receive the y mind intervention. the study aims to assess the feasibility, acceptability and fidelity of delivering the six-session y-mind intervention, and collect preliminary clinical outcomes for depression at 5-month follow up.

Eligibility criteria:
inclusion criteria: * young people aged 15-24 years * scoring 11 or more on the locally validated patient health questionnaire-9 (phq-9) for those aged 18+ and 10 or more on the patient health questionnaire adolescent (phq-a) for those \< 18 years. * willing and able to be followed up for 5 months. * willing and able to provide informed consent if aged 18+, or, if aged below 18, willing and able to give informed assent and to approach a caregiver for informed consent procedures exclusion criteria: * currently receiving any psychological treatment for any common mental disorder through formal health care services * active major mental disorder, advanced physical illness which would interfere with their ability to take part in the study or are actively suicidal (assessed through screening using the p4 screener). * those with visual and/or hearing impairment; defined as being unable to see and read the intervention manual or hear the interventionist sitting approximately 1 metre away. this will be assessed at informed consent procedures.

Keywords: depression psychological therapy
efficacy of lumbar motor control training in treatment of patients with cervicogenic headache

Conditions: Cervicogenic Headache

Summary: this study will be conducted to investigate the effect of lumbar motor control training exercise on headache frequency, duration, intensity and neck functional disability in cervicogenic headache patients

cervicogenic headache is a referred pain spreading from cervical structures supplied by the upper cervical spinal nerve roots (c1-c3), this referred pain that starts from the posterior aspect of the head and neck is usually found to be unilateral, and it also can spread to the frontal, temporal and orbital aspects of the head.the patient frequently reports having a terrible headache, having less neck range of motion, performing less well at work, and having trouble focusing, that may linger for hours. the convergence of primary sensory afferents from cervical nerve roots c1 to c3 with the afferents from the occiput and trigeminal nerve causes the underlying pathology. because of this, the suboccipital muscles particularly, which cervical roots c1 innervates to c3, are potential risk structures. treatment options include posture correction, cervical and upper thoracic strengthening exercises, facet joint manipulation, ultrasound therapy, laser therapy, trigger release therapy, and cervical joint mobilization.famous exercise known as "motor control exercise" attempts to improve the coordination and effectiveness of the muscles that support and govern the spine. it can also improve coordination between the deep neck flexors and superficial neck flexors and between core muscles of the lumbar region. fifty two patients will be randomly assigned to two equal groups; experimental group will receive lumbar motor control and cervical stabilization exercises and control group will receive cervical stabilization exercises only.

Eligibility criteria:
inclusion criteria: * the age of the subjects ranged from 20-40 years old, both genders. * patients with chronic mechanical neck pain with frequent cervicogenic headaches persisting for more than 3 months. * positive flexion rotation test. * unilateral head pain without side shift or bilateral head pain with dominant side headache associated with neck pain and aggravated by neck movement and/or sustained awkward head positioning * joint tenderness in at least one of the upper three cervical joints or the occipital region as detected by manual palpation. * intensity of headache is moderate to severe. * abnormal performance in ccft \< = 26 mmhg * body mass index range from 18 to 25 km/m2 exclusion criteria: * fracture or previous surgery on the vertebral column. * spinal stenosis. * disc prolapsed. * tmj dysfunction. * headache with autonomic involvement, dizziness, or visual disturbance. * congenital condition of the cervical spine. * neck pain of less than three months

Keywords: lumbar motor control cervicogenic hedache cervical stabilization exercises
characterization of treatment responses in lymphedema

Conditions: Lymphedema

Summary: this study is designed to investigate the treatment response of lymphedema, of the upper or lower extremity, during clinical, pharmacologic treatment of lymphedema with oral ketoprofen. correlation of clinical responses (changes in limb volume and skin thickness) with changes in the inflammasome will help to define the molecular substrate of treatment response.

patients presenting to the investigator's clinic for evaluation and treatment of (upper or lower extremity) lymphedema, will be assessed for their suitability (of low risk) for medical treatment with ketoprofen. if there are no contra-indications to taking ketoprofen, after discussion of fda warnings, including provision of a written copy of the fda language to the patient, and with the recommendation to discuss with the primary physician-of-record, patients will be provided with a prescription for ketoprofen 200 mg daily (one capsule taken orally, once daily) or if obtained from a compound pharmacy, ketoprofen 210 mg daily (one capsule taken orally, once daily). participation in this study will be offered. two study visits, at baseline and month 6 are required. measurements (circumferential and skin thickness) and a blood sample will be taken at each study visit. the investigators will try to determine how ketoprofen affects the body tissue by obtaining blood samples and measurements, before starting treatment and at month 6.

Eligibility criteria:
inclusion criteria: * participants with a history of acquired lymphedema * stage 1, 2, or 3 * 18-75 years * clinical use of ketoprofen for lymphedema exclusion criteria: * active cancer, infection, bleeding tendency, inflammatory disease and/or taking anti-inflammatory or anti-leukotriene medication will be excluded. * pregnant or lactating females * inability to take ketoprofen (contra-indicated, e.g patients with known cv, gi, renal, hepatic disease). * other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation, may interfere with interpretation of study results, and in the judgement of the investigator, would make the participation inappropriate for entry into this study.
investigation of genetic disease marker associated with spontaneous haemorrhagic stroke complicating severe pre-eclampsia in pregnancy

Conditions: Hemorrhagic Stroke; Eclampsia

Summary: to search for a genetic marker of hemorrhagic stroke complicating severe eclampsia, a single nucleotide polymorphism (snp) analysis of dna obtained from the peripheral blood of patients with hemorrhagic stroke and normal control will be performed.

detailed description: unrelated korean subjects who have spontaneous hemorrhagic stroke complicating severe eclampsia in pregnancy were recruited in the current study. genotyping for various snp associated due to the linkage disequilibrium patterns is to be performed. genotypes would be statistically compared between patients with hemorrhagic stroke and normal control subjects free of hemorrhagic stroke

Eligibility criteria:
inclusion criteria: -patients with hemorrhagic stroke complicating severe eclampsia in pregnancy exclusion criteria: patients without hemorrhagic stroke complicating severe eclampsia in pregnancy

Keywords: snp
post market study of cerament v/g in pedal osteomyelitis

Conditions: Osteomyelitis - Foot

Summary: the goal of this clinical trial is to look at the outcomes of patients who have had bone infection of their feet treated with a licensed antibiotic paste. the main question it aims to answer is: • how does the bone infection heal in response to the antibiotic paste? participants will: * undergo standard surgery to remove dead bone and drain any pus. * antibiotic paste is injected directly into the middle of the bone at surgery. this is instead of receiving antibiotics directly into their bloodstream for 6 weeks. * recieve one week of tablet antibiotics. * visit clinic 1 month after surgery for a normal clinical appointment. after, a research team member will ask the participant a few questions. the participant will also have a foot x-ray, wound photograph and fill out a short questionnaire. * visit clinic 6 months and 12 months following the surgery. a research team member will ask the participant a few questions. the participant will also have a foot x-ray, wound photograph and fill out a short questionnaire.


Eligibility criteria:
inclusion criteria: * 18 years + * informed consent * operated on for foot sepsis with limb salvage intent. * positive bone biopsy from forefoot or midfoot or positive pus culture from exposed bone * adequate vascularity (1+ palpable pedal pulse, biphasic or triphasic ankle waveforms, or successful revascularisation procedure same admission) * compliant with offloading footwear and diabetic medication exclusion criteria: * allergy or contraindication to gentamicin/vancomycin * life expectancy \&amp \&lt;1 year * unable to make follow up appointments at study centre. * patients with necrotizing infections * gentamicin or vancomycin resistant organism * untreated peripheral arterial disease in angiosome of wound. * buerger's disease * vasculitides * systemic immunosuppressive therapy * pregnancy * breastfeeding * untreated thyrotoxicosis * mysathenia gravis * calcium metabolism disorder * patients taking metformin with estimated glomerular filtration rate (egfr) \&gt; 30ml/min/1.72m2

Keywords: osteomyelitis antimicrobial bone void filler cerament
early vascular ageing in the youth

Conditions: Atherosclerosis; Cardiovascular Risk Factor; Cardiovascular Diseases; Cardiovascular Pathology; Life Style; Vascular Diseases; Vascular Stiffness; Non-Alcoholic Fatty Liver Disease; Hypertension; Obesity; Overweight; Headache; Sleep; Sleep Disorder

Summary: this is a single-center observational study on adolescents to determine predictors of the early steps of the formation of atherosclerosis and to quantify their influence on intima-media-thickness of the carotid artery and the aorta and on the pulse-wave velocity. a long-term follow-up by means of record linkage is furthermore planned to evaluate the effect of early atherosclerosis and the cardiovascular risk profile on future morbidity with a special focus cardio- and cerebrovascular events.

eva4you is a cross-sectional study enrolling 3000 students and apprentices aged between 14 and 19 years. examinations are conducted at schools and companies throughout tyrol, austria and include laboratory measurements; standardized medical interviews; anthropometry; liver elastography; ultrasonography of the carotid artery and the aorta, and blood pressure, bioelectrical impedance; visceral abdominal fat-tissue-thickness measurement, pulse-wave velocity measurements. the study hypothesis is that the cardiovascular risk factors measured already influence the formation of atherosclerosis (measured as carotid and aortic intima-media thickness and pulse-wave-velocity) in adolescents. a long-term follow-up by means of record linkage is furthermore planned to evaluate the effect of early atherosclerosis and the cardiovascular risk profile on future morbidity with a special focus cardio- and cerebrovascular events.

Eligibility criteria:
inclusion criteria: * adolescents at the age of 14 to 19 years * signed informed consent of subjects (and legal guardian if subject \< 18 years of age) exclusion criteria: * persons, who are suspended upon a court order or upon other legal processes or are accommodated according to the hospitalization act, or for whom a custodian is appointed (or appointment is initiated). * persons with impaired power of judgment * persons who are currently engaged in military or community service

Keywords: cardiovascular diseases cardiovascular risk factor atherosclerosis cardiovascular pathology life style vascular diseases early vascular ageing vascular stiffness intima-media thickness non-alcoholic fatty liver disease ultrasonography liver elastography bioimpedance blood pressure body mass index headache sleep adolescence
propel drug-eluting sinus stent family open cohort

Conditions: Chronic Rhinosinusitis (Diagnosis)

Summary: the purpose of this study is to confirm the long-term clinical safety and performance, acceptability of identified risks, and to detect emerging risks based on factual evidence for the propel family of products when used according to labeling (in patients with chronic rhinosinusitis (crs) undergoing sinus surgery). additionally, this study intends to collect data on use of corticosteroid-eluting implants in the european crs population. data collected will be used to ensure continued consistency between clinical data, the information materials supplied by the manufacturer, and the risk management documentation.


Eligibility criteria:
inclusion criteria: * patient or legally authorized representative (lar) provides authorization and/or consent per institution and geographical requirements. * patient has or is intended to receive or be treated with an eligible medtronic product * patient is consented within the enrollment window of the therapy received, as applicable exclusion criteria: * patient who is, or is expected to be, inaccessible for follow-up * participation is excluded by local law * patient is currently enrolled or plans to enroll in concurrent drug/device study that may confound the psr results