Kornimate/medical-research-clean huggingface dataset:
the mary-jane cannabis and heart rhythm trial

Conditions: Premature Atrial Contractions; Premature Ventricular Contractions

Summary: despite recreational cannabis now being legal in 23 states, where more than 100 million americans reside, studies on the actual health effects are limited. this study is a randomized trial, where each participant will be instructed to consume or avoid cannabis on randomly assigned days during a 14-day monitoring period. the goal of this study is to answer the question: "does cannabis use increase the frequency of 'early' and abnormal heart beats?" during the 14-day period, participants will wear an external heart monitor, a glucose monitor, and a fitness tracker to track heart rhythm, glucose levels, step counts, and sleep health. participants will use a mobile app or a text messaging service for daily instructions/reminders on cannabis use, and short surveys. the investigators ask that participants smoke or vape cannabis at least once on days they are instructed to consume cannabis. compelling evidence of heart and other health effects would be important to the clinical care of our patients.

this study is designed as a case-crossover randomized trial, where each participant will be instructed to consume or avoid inhaled cannabis on randomly assigned days during a 14-day monitoring period. participants will be asked to smoke or vape cannabis at least once on days they are instructed to consume cannabis. participants will also wear an external electrocardiographic (ecg) monitor, a continuous glucose monitor, and a fitness tracker for up to two weeks while utilizing a mobile application or text messaging service to receive daily instructions/reminders on cannabis use, and short surveys. the investigators will compare participant self-report of cannabis consumption, glucose monitoring, fitness levels, sleep health, and heart rhythm data in order to better understand the relationship between acute cannabis consumption and heart rhythm changes. a total of 100 participants will be enrolled at the ucsf study site.

Eligibility criteria:
inclusion criteria: 1. are age 21 or older 2. have a smartphone 3. are able to use the eureka mobile application and mosio text messaging software 4. have inhaled cannabis in the past month and on at least four different days in the same week in the past year 5. are willing to consume and abstain from inhaled cannabis for no more than two consecutive days as instructed over the 14-day trial period exclusion criteria: 1. currently pregnant or trying to get pregnant 2. have a medical reason to avoid cannabis 3. are unwilling to avoid all forms of cannabis consumption on days instructed to abstain from cannabis 4. are currently taking anti-arrhythmic medications 5. have a history of atrial fibrillation or heart failure 6. have congenital heart disease 7. have an implantable cardioverter-defibrillator or pacemaker 8. have had a previous cardiac ablation procedure

Keywords: cannabis marijuana weed arrhythmias cardiac ectopy pacs pvcs heart rhythm
integrative analysis of pulmonary sarcomatoid carcinoma (psc)

Conditions: Lung Cancer

Summary: integrative analysis of pulmonary sarcomatoid carcinoma (psc)

the investigators will analyzed proteomes of paired normal lung tissues and pulmonary sarcomatoid carcinoma with or without metastasis, sequenced transcriptomes, perform whole exome sequencing, and single nucleotide polymorphism (snp) array profiling for triplets, each comprising normal lung tissue, primary pulmonary sarcomatoid carcinoma, and its synchronous matched metastasis, as well as analyzed genomics of lung cancer characterized previously by the cancer genome atlas (tcga) to conduct integrated proteogenomic analyses.

Eligibility criteria:
inclusion criteria: * age ≤ 70 years with histologically proven lclc * no severe major organ dysfunction * world health organization (who) performance status of 0 or 1 * no prior cancer chemotherapy exclusion criteria: * age ≥ 70 * severe major organ dysfunction * who performance status of \>1 * prior cancer chemotherapy

Keywords: psc integrative analysis ihc wes rna sequencing
the measurement of vital signs in children by lifelight® software in comparison to the standard of care

Conditions: Cardiovascular Diseases; Respiratory Disease; Febrile Illness; Pediatric ALL

Summary: a prospective basic science study for collection of training and testing data for development of lifelight® junior

this study will be hospital-based, including paediatric emergency department (ped), inpatient wards and outpatient departments). the participants will have their vital signs (such as heart rate, respiratory rate, oxygen saturation, blood pressure and temperature) measured using standard-of-care methods. concurrent with this, videos of the participants' face/torso, and audio of the sounds made by the participants (cry, wheeze, cough) will be recorded. these data will later be used to train the lifelight® junior algorithms so that the technology can help in detection of illness and deterioration in children. primary objective collect the data needed to develop lifelight® junior so that it can measure the heart rate, respiratory rate and oxygen saturation of children. secondary objective 1. assess the feasibility of developing other (direct or indirect) measurement functions in lifelight® junior, including temperature, blood pressure, heart rate variability and audio analysis (cry, wheeze, cough). 2. evaluate the impact of subject-specific variables on the vital sign measurements e.g., medication, cosmetics, facial/body hair and skin tone. 3. obtain data to understand patient and parent/guardian/carer vital sign measurement habits and preferences 4. assess the usability of lifelight® junior for measuring vital signs in children to ensure the study collects data that can train lifelight® junior in an efficient way, the recruitment should be divided as follows: * at least 12% of study participants should fall into each of the following age bands: * age 0-1 * age 1-2 * age 2-5 * age 5-11 * age 11-14 * age 14-18 * at least 40% of the study participants shall be male and at least 40% shall be female. * at least 40% of the study participants shall be each of the following: * febrile (≥ 38°c) measured how? * afebrile * ill (as judged by the clinical staff), of whom at most 50% shall have an acute respiratory illness e.g., bronchiolitis, asthma, viral induced wheeze, pneumonia, croup, etc. * well, including children with a minor injury ideally, 15% of participants should have a fitzpatrick skin tone of 4, 5 or 6 first reference to this - need to bring it in earlier and to reference it. however, this is not a hard target as achieving this figure is dependent on the demographic diversity of the study region.

Eligibility criteria:
inclusion criteria: * children (0-18 years old) attending the paediatric ed or who are inpatients on the paediatric wards at stsft exclusion criteria: * critically ill children (judged so by treating physicians), including unconscious children * children who are non-compliant in terms of excessive movement during the measurement * children of parents/guardians/carers who are non-english speakers

Keywords: video audio vital signs
efficacy and safety of plastic, covered and uncovered self-expandable metal stents in the treatment of malignant biliary obstructions (neostent)

Conditions: Common Bile Duct Stricture; Jaundice; Malignant

Summary: the aim of the study is to evaluate the efficacy and safety of the various types of stents available for biliary drainage in patients with neoplastic stenosis of the common bile duct and to evaluate the adherence to the current guidelines available.

biliary drainage before surgery or chemotherapy is a common practice in patients with neoplastic stenosis of the common bile duct, often required by the presence of clinical conditions such as the onset of cholangitis or severe jaundice. the endoscopic approach has now been identified by the literature as the preferential drainage route, due to a lower incidence of adverse effects, liver or intraperitoneal metastases and lower costs associated with this technique compared to percutaneous drainage. the latest guidelines from the european society of gastrointestinal endoscopy recommend the placement of a 10 mm diameter self-expandable metal stent (sems) as the first choice for endoscopic drainage in patients with extra-hepatic biliary stenosis of neoplastic origin. compared to plastic stents, sems placement is associated with a lower risk of developing stent dysfunction and/or cholangitis, lower risk of reintervention, and better patient survival. however, among the various types of metal stents available, to date there is no agreement on which type is the most suitable, as data on efficacy and post-interventional morbidity and mortality of the fully or partially covered and uncovered metal stents are contradictory. the aim of the study is to evaluate the efficacy and safety of the various types of stents available for biliary drainage in patients with neoplastic stenosis of the common bile duct and to evaluate the adherence to the current guidelines available.

Eligibility criteria:
inclusion criteria: * common bile duct stricture (i.e. jaundice and/or cholangitis) of malignant origin * patients \> 18 years old * obtaining informed consent exclusion criteria: - lack of sufficient clinical and laboratory data to define clinical efficacy and/or follow-up available \<1 month

Keywords: biliary stent jaundice pancreatic cancer common bile duct cancer
complex-posttraumatic stress disorder - cultural adaptation of a therapeutic manual and development of a culture-specific diagnostic module for refugee populations in switzerland (pilot trial)

Conditions: Complex Post-Traumatic Stress Disorder

Summary: in january 2022, the world health organization (who) launched the 11th edition of the international classification of diseases (icd-11). this diagnostic manual includes the new diagnosis of complex post-traumatic stress disorder (cptsd). this new diagnostic category describes difficulties that may arise as a result of multiple, prolonged or repeated trauma, from which it is difficult or impossible to escape, such as torture, domestic violence or childhood sexual abuse. people affected by cptsd often have difficulty regulating their emotions and maintaining relationships with others, and they often show a negative self-concept. evidence from the field of cultural clinical psychology indicates cultural variation in the cptsd symptoms across different cultural groups. in addition, psychopathology is shaped by structural factors such as inequality and/or discrimination. this research project aims to highlight such cultural and structural aspects related to ptsd and cptsd among refugee populations in switzerland. a diagnostic interview and a therapeutic manual will be culturally adapted and pilot tested with a small sample (n = 24).


Eligibility criteria:
inclusion criteria: * refugees and asylum seekers from the greater middle eastern and northern africa (mena) region, regardless of their residence permit. the four languages that will be used for the planned project are: farsi/dari, arabic, turkish, and kurdish (kurmanji). * "high risk" (i.e., minimally 8 points) on the questionnaire process of recognition and orientation of torture victims in european countries to facilitate care and treatment (protect); * age 18 or older; * informed consent signed exclusion criteria: * imminent risk of suicide; * acute psychosis; * severe alcohol and/or drug addiction.
mother-child interaction assessment training for pediatricians

Conditions: Child Behavior Disorders; Mother-child Relations; Depression, Postpartum

Summary: the originality of the mocitraining study lies in the integration of infant and maternal care during the pediatric consultation and the assessment of the impact of this type of care in the short and medium term on the mocitraining program could contribute to improving the quality of parent-child interactions.


Eligibility criteria:
inclusion criteria: * each child will be included with his biological mother at the first-month visit after birth. * age: 1 month + / - 15 days (child), accompanied by his biological mother * mother able to read french; * signed consent letter after complete information of parents about the mocitraining study, its principle, advantages and disadvantages. exclusion criteria: * preterm babies. * children from a twin or multiple pregnancy. * children with somatic diagnosis explaining the presence of digestive, sleeping or interactional disorders. * refusal to participate after clear information about the study; * refusal to sign the consent letter; * refusal to be informed of a diagnostic hypothesis; * participants not covered by the social security system; * participants incapable of consenting or under legal protection (guardianship or curatorship).

Keywords: mass screening pediatrician training
effects of resistant potato starch on the gut microbiota

Conditions: Microbiota

Summary: this was a randomized, double-blind, three-arm, parallel group clinical trial, which assessed the shifts that occur in microbial populations after four weeks of supplementation with resistant potato starch (solnultm) at two different dosages, in comparison to a placebo in healthy adults.


Eligibility criteria:
inclusion criteria: * bmi between 18.0 and 34.9 kg/square meter (inclusive) that were generally healthy as determined by medical history and screening blood work. exclusion criteria: * diagnosis of irritable bowel syndrome (ibs), dyspepsia, significant gastrointestinal disorders, or other major diseases.

Keywords: microbiota resistant potato starch bristol stool chart diarrhea constipation bloating abdominal pain gas well-being
early versus delayed timing of intervention in patients with acute coronary syndromes

Conditions: Unstable Angina; Myocardial Infarction

Summary: the timing of intervention study is a prospective, randomized, international, multicentre comparison of the relative efficacy, safety, and cost effectiveness of a management strategy of coronary angiography and intervention performed within 24 hours of randomization versus delayed coronary angiography and intervention in patients after 36 hours with acute coronary syndromes (acs).


Eligibility criteria:
inclusion criteria: 1. patients presenting or admitted to hospital with symptoms suspected to represent an acute coronary syndrome (unstable angina or mi without persistent st elevation) i.e., clinical history consistent with new onset, or a worsening pattern, of characteristic ischemic chest pain or ischemic symptoms occurring at rest or with minimal activity (lasting longer than five minutes or requiring sublingual nitroglycerin for relief of the pain) 2. able to randomise within 24 hours of the onset of the most recent episode of symptoms 3. at least two of the three following additional criteria: * age more than or equal to 60 years * troponin t or i or creatine kinase - myocardial bands (ck-mb) above the upper limit of normal for the local institution * electrocardiogram (ecg) changes compatible with ischemia (i.e., st depression at least 1 mm in two contiguous leads or t wave inversion mroe than 3 mm or any dynamic st shift or transient st elevation) 4. written informed consent dated and signed exclusion criteria: 1. age less than 21 years 2. not a suitable candidate for revascularisation 3. co-morbid condition with life expectancy less than six months

Keywords: timing intervention early delayed acute coronary syndromes pci angiography non st-segment elevation myocardial infarction unstable angina
bfrt for subacromial pain

Conditions: Shoulder Pain

Summary: the goal of this pilot clinical trial is to learn if blood flow restriction training is safe and feasible in patients with subacromial pain. the main questions the investigators aim to answer are: * what problems do participants with shoulder pain encounter when training with blood flow restriction? * is it feasible to apply blood flow restriction training as part of a physical therapy intervention? * what are some preliminary effects of blood flow restriction training on the recovery of shoulder function and strength? the investigators will compare active blood flow restriction training to sham (an inactive procedure designed to mimic the active training as closely as possible). participants will: * visit the clinic for physical therapy visits and exercise with blood flow restriction training for up to 8 weeks * visit the clinic for tests before starting the treatment, during the treatment (4 weeks), and after the end of the treatment (8 and 26 weeks).


Eligibility criteria:
inclusion criteria * between 18 and 50 years of age * unilateral pain in the anterolateral shoulder * self-reported shoulder function of ≤7 (10, full function) * at least 90° of active shoulder elevation * 3 out of 5 positive tests to define subacromial pain. exclusion criteria (general): * history of shoulder fracture, frozen shoulder, or shoulder surgery * history of cardiovascular, neurologic, and pulmonary conditions that would impair the subject's ability to participate in physical therapy * active treatment for cancer * uncontrolled diabetes * uncontrolled high blood pressure * corticosteroid injection at the shoulder within 6 weeks * imaging evidence of rotator cuff tears * pregnancy exclusion criteria (blood flow restriction training specific) * contraindications to bfrt (sickle cell anemia, deep vein thrombosis, peripheral circulatory diseases) * taking anticoagulant or antiplatelet drugs

Keywords: blood flow restriction training bfrt bfr exercise subacromial pain rotator cuff tendinopathy subacromial impingement rotator cuff related shoulder pain
ability of rotator cuff muscle strength levels, assessed by isokinetic dynamometry, to predict return to sport after shoulder stabilization surgery by open latarjet procedure

Conditions: Latarjet; Shoulder Injuries; Rotator Cuff Injuries

Summary: the stabilization surgical treatment by open latarjet procedure is one of the reference treatments after anterior glenohumeral dislocation in athletes. this surgical technique allows low recurrence rates and high return to sport rates. indeed, more than 90% of athletes return to sport after this type of surgery, but only 60% are able to resume the same activity as a preinjury level of performance. therefore, adaptations in the postoperative management of athletes patients seem necessary. isokinetic dynamometry is considered the gold standard to provide an objective assessment of muscle strength abilities, particularly in the clinical setting. although rehabilitation exercises are prescribed early after the latarjet procedure, muscle deconditioning occurs during the postoperative phase, limiting the abilities of the rotator cuff muscles to provide stability to the glenohumeral joint. therefore, recovery of all components of strength, i.e. maximal strength, power, and strength endurance of the rotator cuff muscles appears crucial for the athletes to return to their sport at the pre-injury level. however, at present, the strength levels to be recovered remain to be defined.


Eligibility criteria:
inclusion criteria: patient group: * be aged between 18 and 45 * occurrence of the injury during the practice of a sporting activity * post-traumatic anterior glenohumeral subluxation/dislocation * contralateral shoulder with no history of injury * no other associated shoulder pathology * patient scheduled for shoulder stabilizing surgery using an open latarjet procedure performed by one of the surgeons at the santy orthopedic center (lyon) * no contraindication to isokinetic assessment * patient having signed informed consent * subject affiliated or beneficiary of a social security scheme healthy volunteers: * be aged between 18 and 45 * regularly practice a sporting activity * no contraindication to isokinetic assessment * person having signed informed consent * subject affiliated or beneficiary of a social security scheme exclusion criteria: patient group: * contraindication from the sports clinician or surgeon * have another pathology in the upper limbs. * have constitutional hyperlaxity * protected subject: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision healthy volunteer group (athletes without a history of shoulder pathology): * declare a history of pain/injury in the upper limbs in the last 6 months * declare a history of orthopedic surgery in the upper limbs * protected subject: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision
altered chemotherapy sequencing during neoadjuvant therapy for patients with stage ii or iii rectal adenocarcinoma

Conditions: Stage II Rectal Cancer; Stage III Rectal Cancer

Summary: the primary objective of the pilot portion of this study is to establish the safety and tolerability of an extended treatment break period in patients who have undergone neoadjuvant chemoradiotherapy as well as use of systemic therapy during this break.

the proposed protocol aims to continue tumor-directed therapy during the typical "break period" in an effort to improve on both local tumor response as well as distant disease control. first, the duration from completion of chemoradiotherapy would increase from 6-8 weeks to 9-11 weeks. as noted above, this may allow for further cell death with resultant pathologic downstaging. secondly, the protocol calls for continued systemic therapy during the 9-11 week period, thus allowing continuation of therapies directed towards both the primary as well as distant sites of disease. the primary aim of this pilot study would be to establish the feasibility of this intensified neoadjuvant approach, especially with respect to tolerability of the subsequent pelvic surgery. a subsequent phase ii portion will evaluate the efficacy of this treatment approach.

Eligibility criteria:
inclusion criteria: 1. signed study-specific informed consent form 2. age \> 18 years old 3. zubrod performance status 0-1 4. biopsy proven primary malignancy 5. ajcc stage ii or iii disease (t3-4 and/or n1-2 disease) as determined by endoscopic ultrasound and/or mri staging 6. pretreatment rectal endoscopic ultrasound and pelvic mri, colonoscopy, ct of chest, abdomen, and pelvis, and laboratory values as discussed below exclusion criteria: 1. history of inflammatory bowel disease 2. previous pelvic radiotherapy 3. a major psychiatric illness which would limit understanding of the proposed protocol treatment and consent process. 4. men and women of reproductive potential must agree to use an effective contraception method 5. pregnant or lactating women 6. severe, active co-morbidity, defined as * unstable angina and/or chf requiring hospitalization within the last six months * transmural myocardial infarction within the last 6 months * acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration 7. presence of metastatic disease, including liver metastases 8. laboratory values out of range

Keywords: rectal cancer
ultrasound guided bilateral erector spinae plane block in caesarean delivery

Conditions: Pain

Summary: erector spinae plane block (espb) is a regional anesthesia technique described three years ago. its use for many indications has been identified by case reports in the literature. as the investigators have considered that espb could be efficacious for providing postoperative analgesia in the cesarean section, the investigators have implemented the application of this blockade into practice at the clinic. the main purpose of this study is to evaluate the analgesic effect of ultrasound-guided bilateral low thoracic espb in cesarean section.


Eligibility criteria:
inclusion criteria: * patients undergoing cesarean section under spinal anesthesia exclusion criteria: * patients undergoing cesarean section under general anesthesia morbidly obesity, asa iii - iv , infection of the skin at the site of needle puncture area, patients with known allergies to any of the study drugs, coagulopathy, recent use of analgesic drugs