Kornimate/medical-research-clean huggingface dataset:
sleep in hospitalized children at mskcc

Conditions: Pediatric Cancer Patients

Summary: the investigators want to better understand how children sleep at night at mskcc, so that the investigators can learn how to improve the sleeping environment.


Eligibility criteria:
inclusion criteria: * parent/patient must provide written consent * patient must be between the ages of: newborn - ≤ 18 years of age * patient is expected to be admitted to the pediatric floor at msk for at least 2 nights (patients/parents will not be approached for consent on day of admission or day of discharge) * patient/parent must be english speaking exclusion criteria: * expected length of stay of fewer than 2 nights (for example.: if admitted monday and discharged tuesday, patient/parent will not be eligible). * patient /parent unable to complete questionnaire due to education or language barriers. * patients admitted to the picu. (only children on m9 will be included. it is known that sleep in the picu is highly disordered; as such, we will be excluding picu patients from this study).

Keywords: assess sleep sleep deprivation 16-866
a study to evaluate the efficacy and safety of amg 714 in adult patients with celiac disease

Conditions: Celiac Disease

Summary: this study is designed to evaluate the efficacy and safety of amg 714 for the attenuation of the effects of gluten exposure in adult patients with celiac disease during a gluten challenge.


Eligibility criteria:
inclusion criteria: * diagnosis of celiac disease by intestinal biopsy at least 12 months prior to screening * on a gluten-free diet for at least 12 months * negative celiac serology * avoidance of pregnancy exclusion criteria: * severe complications of celiac disease, such as refractory celiac disease * celiac symptoms * other concomitant autoimmune disease * chronic, active gastrointestinal disease * infections, concomitant diseases * prohibited medications

Keywords: celiac gluten interleukin 15 (il-15) amg 714 gluten challenge
effects of sleep duration and architecture on insulin sensitivity

Conditions: Insulin Resistance

Summary: this pilot clinical trial will test the hypotheses that sleep restriction (for 5 nights), in comparison to "normal sleep", will: 1. decrease peripheral insulin sensitivity and glucose tolerance, as measured by the hyperinsulinemic-euglycemic clamp and oral glucose tolerance test. 2. decrease hepatic insulin sensitivity, as assessed by stable isotope studies of endogenous glucose production, gluconeogenesis and glycogenolysis.

over the past 50 years, the incidence of diabetes has increased dramatically, while sleep duration in the us has decreased significantly. epidemiological studies and small clinical trials suggest that these trends are causally related. in this study, our goal is to determine the mechanisms by which decreased sleep duration directly affects insulin sensitivity. the investigators will perform a clinical study in 20 healthy volunteers to determine whether 5 nights of sleep restriction decreases insulin sensitivity in the peripheral tissues (ie, skeletal muscle) or liver. peripheral insulin sensitivity will be measured by the hyperinsulinemic-euglycemic clamp, and hepatic insulin sensitivity will be quantified by measurement of hepatic glucose production, gluconeogenesis and glycogenolysis (using stable isotope tracer methods). subjects will be randomized to an initial period of "normal sleep" or sleep restriction and will be admitted to the clinical research center (crc) for 9 days to undergo comprehensive metabolic studies and sleep assessments under the assigned sleep condition. after a 1-month washout period, subjects will be re-admitted to the crc to undergo these same assessments under the opposite sleep condition.

Eligibility criteria:
inclusion criteria: * age 18-45 years * regular work hours (ie, no night-time or shift work within the past 6 months) * pittsburgh sleep quality index (psqi) score \<5 * average nightly sleep duration 6-9 hours (per screening actigraphy) exclusion criteria: * current or prior diabetes, gestational diabetes, impaired glucose tolerance or impaired fasting glucose * type 2 diabetes in biological parents * bmi \>=25 * pregnancy * chronic medical condition, including: psychiatric disorders, heart disease, pulmonary disease, infectious diseases, rheumatological and neurological disorders * use of prescribed medications on a regular basis. * history of disorder involving hypothalamic, pituitary or adrenal glands * history of or current sleep disorders (insomnia, restless leg syndrome, sleep disordered breathing, narcolepsy, etc) * anemia * cognitive impairment

Keywords: diabetes
retrospective study of clinical practice and management of imported schistosomiasis in france

Conditions: Schistosomiasis

Summary: schistosomiasis is a major public health issue. clinical guidelines for the management of imported schistosomiasis are heterogeneous. the objective of this study is to describe the clinical management of schistosomiasis imported cases in france, regarding diagnosis, treatment and follow-up.

schistosomiasis is a major public health issue. clinical guidelines for the management of imported schistosomiasis are heterogeneous. the objective of this study is to describe the clinical management of schistosomiasis imported cases in france, regarding diagnosis, treatment and follow-up. it is a multicentric, retrospective, descriptive study. inclusion criteria are an age ≥ 18, a positive western blot and / or a positive microscopy exam. data concerning clinical presentation, biological samples, imaging, treatment and follow-up will be assessed. a descriptive analysis will be performed.

Eligibility criteria:
inclusion criteria: * age ≥ 18, positive schistosomiasis immunoblot and / or positive microscopy examination for schistosomiasis eggs exclusion criteria: * - patients under guardianship

Keywords: schistosomiasis, retrospective
multimodal epicardial and endocardial coronary physiological evaluation in pathological situations (phyco)

Conditions: Coronary Artery Disease; Coronary Microvascular Dysfunction

Summary: when performing coronary angiography in a stable situation, the identification of an intermediate coronary lesion (between 50 and 70%) is common, and requires additional functional evaluation. the gold standard for this evaluation is fractional flow reserve (ffr). ffr is a flow ratio transformed into a pressure ratio by simplification, neglecting some parameters, especially microcirculatory resistance. the aim of this study is to investigate hemodynamic and structural assessment induced in specific conditions, and their repercussion on functional assessment by ffr to implement the diagnostic approach and personalize it for each patient.


Eligibility criteria:
inclusion criteria: * intermediate coronary lesion (between 50 and 70%) exclusion criteria: * hemodynamic instability * adenosine hypersensitivity * asthma * severe chronic obstructive pulmonary disease * long qtc * wolff parkinson white * high degree atriovenricular block * left-right shunt * carotid artery stenosis with hemodynamic insufficiency * pregnancy

Keywords: coronary artery disease coronary physiology index of microcirculatory resistance (imr)
methemoglobinemia following intravenous iron treatment

Conditions: Methemoglobinemia; Anemia; Iron Deficiencies; Side Effect

Summary: methemoglobinemia as a side effect of treatment with intravenous iron has not previously been described. this study aims to assess methemoglobin levels in patients with anemia following treatment with intravenous iron, administered as ferric carboxymaltose or ferric derisomaltose.

methemoglobin is an isoform of hemoglobin without oxygen carrying properties. higher levels of methemoglobin may impact oxygen transport of the blood and increase the risk of tissue hypoxia. methemoglobinemia has been reported as side effect of different drugs such as antibiotics or local anesthetics, but not after iron preparations. there is only one case report of increased levels of methemoglobin following intravenous iron therapy. patients with anemia due to iron deficiency can be treated with intravenous iron preparations such as ferric carboxymaltose or ferric derisomaltose. anemia itself reduces oxygen transport of the blood, increasing the risk of tissue hypoxia due to methemoglobinemia in those patients. this study aims to assess methemoglobinemia following treatment with intravenous iron in patients with anemia. the report will include case reports of patients with severe anemia who developed methemoglobinemia following treatment with ferric derisomaltose. furthermore, methemoglobin levels are evaluated before and after intravenous iron administration in a cohort of adult patients with anemia who are scheduled to receive ferric carboxymaltose or ferric derisomaltose in routine care.

Eligibility criteria:
inclusion criteria: for patients in the cohort study: * anemia * prescription of administration of intravenous iron (ferric carboxymaltose or ferric derisomaltose) for patients in the case report: - patients with severe anemia who developed methemoglobinemia following administration of ferric derisomaltose exclusion criteria: * declined consent * known or suspected methemoglobinemia of genetic or other origin * previous administration of intravenous iron within one week before study sampling.

Keywords: intravenous iron ferric carboxymaltose ferric derisomaltose
effect of hydroxychloroquine in covid-19 positive pregnant women

Conditions: COVID-19; SARS-CoV-2; Pregnant Women; Hydroxychloroquine

Summary: covid-19 was declared a pandemic on march 11th. efforts to save lives are essential as we will face increasing morbidity with rising demands on health care resources. since pregnant women with covid-19 have systematically been excluded from drug trials, potential treatment options for these high-risk individuals remain untested. the aim of our trial is to determine whether hydroxychloroquine given to covid-19 positive pregnant women can reduce covid-19-related hospital admissions, thereby allowing women to stay at home while limiting utilization of hospital resources and resulting exposure of health care providers.

due to physiologic and immune changes, pregnant women are at high risk of severe complications and mortality from covid-19 infections. despite this, epidemiologic data on sars-cov-2 infection in pregnancy is currently limited to small case-series describing a clinical course ranging from mild to critical illness requiring extracorporeal membrane oxygenation. chloroquine and hydroxychloroquine (hcq) have demonstrated activity against sars-coronaviruses in laboratory studies and are being tested in covid-19 positive patients. hcq appears more promising than chloroquine due to its greater effectiveness against sars-cov-2 in vitro and better safety profile. to date, pregnant women have been systematically excluded from trials conducted in the general outpatient population. thus, we will carry out a randomized, placebo-controlled, double blinded trial of hcq (considered safe in pregnancy in pregnant women with early covid-19 infection across canada to evaluate its effect in reducing covid-19-related hospitalizations. this outpatient intervention is of paramount importance as its goal is to avoid overloading emergency rooms, obstetric triage, inpatient wards and critical care units. upon completion of 6-month, our results can be directly applied to clinical care.

Eligibility criteria:
inclusion criteria: * women with a self-reported live pregnancy \>14 weeks * presently in the outpatient setting (i.e. not admitted to the hospital) * tested positive for covid-19 within last 7 days * must be living in canada exclusion criteria: * known glucose-6-phosphate dehydrogenase (g6pd) deficiency * known cardiac disease (or under investigation) * currently taking medication contraindicated as per health canada list for hydroxychloroquine * known retinopathy * known hypersensitivity to 4-aminoquinoline compounds * already taking hydroxychloroquine * unwilling to answer follow-up questionnaires * currently in labor * inpatient women at time of covid-19 diagnosis.

Keywords: covid-19 sars-cov-2 pregnancy hydroxychloroquine
hi-vision pilot study

Conditions: Postoperative Hypoxia

Summary: a prospective cohort pilot study of non-cardiac patients to determine the feasibility of recruiting 150 patients to undergo postoperative continuous hemodynamic monitoring for up to 3 days.

patient will start wearing the philips' hemodynamic and ecg monitor in the post anaesthesia care unit (pacu). this device will continuously measure heart rate, pulse oxymetry, and st-segments. the device will measure blood pressure every hour from 7 am to 10 pm and every 2 hours from 10 pm to 7 am. patients will have postoperative troponin i monitoring and telephone follow-up at 30 days postop.

Eligibility criteria:
inclusion criteria: we will enroll patients aged 45 years or older undergoing noncardiac surgery who fulfilled 2 or more of the following risk factors: * history of coronary artery disease * history of stroke or transient ischemic attack (tia) * history of hypertension * history of diabetes * history of peripheral vascular disease * history of congestive heart failure * preoperative creatinine \> 175 umol/l * a planned admission for ≥48 hours * patients receiving a general or regional anesthetic exclusion criteria: * patients unable to provide informed consent. * patients who undergo procedure performed under infiltrative or topical anesthesia. * patients previously enrolled in the hi-vision study. * patients who refuse 30-day follow-up.
risk factors for residual neoplasia after endoscopic mucosal resection

Conditions: Colorectal Cancer

Summary: laterally spreading tumors (lst) are important precursosrs of invasive colorectal cancer. endoscopic treatment has replaced surgery in most of the cases. nevertheless, after conventional endoscopic mucosal resection (cer), local residual neoplasia (lrn) is an issue. therefore, endoscopic follow-up and treatment are necessary. to decrease its occurrence, the risk factors of lrn shoudl be identified. thereafter, in high-risk patients, other modalities of initial treatment including endoscopic submucosal dissection (esd) and surgical treatment, could be considered. the purpose of this prospective study is to identify risk factors associated with the presence of lrn after cer of lsts.


Eligibility criteria:
inclusion criteria: * all consecutive patients referred for emr of lst exclusion criteria: * polyposis syndromes * previous therapeutic attempt

Keywords: endoscopic mucosal resection laterally spreading tumor local residual neoplasia colonoscopy therapy
open label pharmacokinetic in adult patients with ventilator-associated pneumonia

Conditions: Ventilator Associated Pneumonia

Summary: the purpose of this research study is to measure the levels of ceftobiprole in the blood, urine and tissues of the lungs during and after administration of four doses of ceftobiprole. safety of the drug will also be evaluated.

patients will receive a intravenous dose of ceftobiprole infused over 4 hours. multiple blood samples will be obtained to determine the concentration of ceftobiprole in the blood. bronchoalveolar lavage (bal) samples will be collected to determine the concentration of ceftobiprole in the bal fluid. the penetration of the drug into the lung will be calculated. four 1000mg administered every 8 hours

Eligibility criteria:
inclusion criteria: * informed consent * between 18 and 75 years of age inclusive * vap - 48 hours after onset of mechanical ventilation * bmi 18 - 35 inclusive * albumin \< 3.3 g/dl or clinical evidence of edema * negative pregnancy test * expected survival of at least 7 days exclusion criteria: * renal impairment (crcl \< 80 ml/min) * known drug allergy (including penicillin, cephalosporin, carbapenems, or other beta-lactams) * history of seizures * sustained shock, unresponsive to sympathomimetics * conditions that may have jeopardized adherence to the protocol (nyha class 4 cardiac disease, \>15% total body burn or significant third degree burn)

Keywords: vap
efficacy and safety of anti-cd25 rhmab in the treatment of steroid-refractory cgvhd

Conditions: cGVHD

Summary: the study plan aims to include patients who have been diagnosed with steroid-refractory chronic gvhd in the liver following allogeneic hematopoietic stem cell transplantation. after obtaining informed consent, the patients will be randomly assigned to either the anti-cd25 rhmab treatment group or the traditional treatment group. the objective is to assess the effectiveness and safety of anti-cd25 rhmab in the treatment of severe chronic gvhd affecting the liver.


Eligibility criteria:
inclusion criteria: 1. age 16 and 65 years 2. received allogeneic hematopoietic stem cell transplantation 3. developed chronic gvhd in the liver after transplantation 4. ineffective prednisone treatment prior to screening 5. received ≤4 lines of systemic therapy prior to screening 6. after informed consent, the patient agreed to receive anti-cd25 rhmab treatment exclusion criteria: 1. elevation of bilirubin, alt, or alkaline phosphatase due to reasons other than chronic gvhd 2. no prior treatment with prednisone 3. overlap syndrome 4. uncontrolled active infection 5. organ failure 6. early progression or recurrence of hematologic diseases 7. allergy to anti-cd25 rhmab 8. received other interleukin-2 receptor monoclonal antibody treatment due to various reasons within one month after transplantation 9. participated in other clinical studies within one month
effects of neuromuscular electrostimulation on scapular stability

Conditions: Adult Female Handball Player

Summary: injuries and shoulder pain are common problems in handball, more often among female athletes. the impact on performance and participation shows the need to work on the risk factors to minimize the damage. it has been found an association between scapular dysfunction and pain in the shoulder. currently there are many exercise programs, but few with electrotherapy implemented. the aim of the study is to assess the effect of a therapeutic physical exercise program for scapulo-humeral stabilitation with and without electrotherapy on scapular stability, glenohumeral internal rotation and external rotation strength.


Eligibility criteria:
inclusion criteria: * to have more than 18 yo * to be female * to do at least 5 hour of sport training per week in last two years * to be part of federated club that allows them in their weekly practice to participate in recreational matches or small local championship during weekends. * to have scapular diskinesis by mcclure scale exclusion criteria: * to have an actual injury * to have an history of injury in last 12 months * to take drugs that can affect to control motor. * to be part or participate in a control motor program or specific prevention program * to have a recent surgery in last year in upper or back. * a score below 45 points on the personal psychological apprehension scale.

Keywords: "electric stimulation therapy" "resistance training" "overhead sports" "risk factors" "scapular anomalies"
the relationship of shear wave elastography findings with pain threshold and quality of life in patients with lipedema

Conditions: Pain; Lipedema

Summary: the aim of this study is to evaluate the relationship between disease severity and subcutaneous tissue shearwave elastography findings with pain threshold and quality of life in patients diagnosed with lipedema.

patients diagnosed with lipedema were divided into 3 stages according to disease severity. pain level was evaluated with visual analogue scale, pain threshold with algometric measurement, and quality of life with eq-5d general quality of life scale. all patients underwent measurements using b-mode ultrasound and subcutaneous elastic modulus with shear wave elastography (swe) imaging of lower limbs at three anatomical levels.

Eligibility criteria:
inclusion criteria: * female patients diagnosed with lipedema exclusion criteria: * under 18 years of age, * patients with edema of cardiac or nephrogenic origin, diabetes mellitus, thyroid dysfunction, patients with lymphedema or chronic venous insufficiency, oncology patients, * individuals with polyneuropathy, radiculopathy, or advanced degenerative diseases affecting the extremities within the last 6 months, based on clinical findings and medical history. * patients using antiepileptics and antidepressants, * individuals unable to cognitively tolerate participation in the study were also excluded.

Keywords: shear wave elastography pain lipedema
the use of laser in the treatment of atrophic vulvovaginitis

Conditions: Lasers; Atrophy of Vagina; Atrophy Vulva

Summary: this study evaluates the efficacy and security of laser for atrophy treatment. half of participants will receive the laser treatment and the other half placebo.

thermal laser treatments are proposed as the newest treatments for atrophy. through the thermal effect it would stimulates de mucosa, enhances the collagen component and the vascularization. collagen remodeling and new collagen synthesis has been suggested as a mechanism of laser induced skin resurfacing and remodeling of vaginal connective tissue.

Eligibility criteria:
inclusion criteria: * menopause women with vulvovaginal symptoms of atrophy * no previous estrogen treatment for the last 30 days * active sexual life (vaginal penetration) * accept to participate * pap atrophy or hypotrophy in the last year exclusion criteria: * vulvovaginal diseases * abnormal uterine bleeding * antidepressants drugs * uncontrolled diabetes * cervical intraepithelial lesions or cancer * photosensitized or under treatment with photosensibilized drugs * collagen diseases * vulvovaginal infections in the last 15 days * immunosuppressed patients or under immunosuppressed treatments