Kornimate/medical-research-clean huggingface dataset:
neuraxial labor analgesia and offspring neurodevelopment

Conditions: Offspring, Adult; Labor Pain; Maternal Anesthesia and Analgesia Affecting Fetus or Newborn; Neurodevelopmental Delay; Postpartum Depression

Summary: how perinatal factors affect the long-term development of children has always been an issue of much concern. this study is designed to explore the potential impact of maternal neuraxial labor analgesia exposure on offspring neurodevelopment.

neuraxial labor analgesia, including epidural analgesia and combined spinal-epidural analgesia, is a well-established technique to alleviate labor pain. it can help to reduce the maternal stress response during labor and might be associated with a lower risk of maternal postpartum depression; which may be beneficial to the long-term neurodevelopment in offspring. on the other hand, neuraxial labor analgesia is associated with increased risks of intrapartum maternal fever and instrumental delivery, which may produce potentially harmful effects. in addition, it has been reported that the anesthetic exposure during neuraxial analgesia may lead to fetal-neonatal depression and even neurotoxic effects of less mature neonatal brain. taking all these into account, the potential long-term effects of neuraxial analgesia on offspring neurodevelopment is still controversial and deserves further study. the objective of study is to investigate if there is any association between maternal neuraxial analgesia exposure during labor and risk of offspring neurodevelopment delay at age 24 months.

Eligibility criteria:
inclusion criteria: 1. primiparae between 18 and 35 years of age with term single cephalic pregnancy; 2. undergo regular prenatal examination in the study centers; 3. preparing to deliver vaginally. exclusion criteria: 1. history of psychiatric diseases (indicate those that are diagnosed before or during pregnancy by psychiatrists); 2. history of diseases involving the hypothalamic-pituitary-adrenal axis; 3. presence of contraindications to epidural analgesia, which includes: (1) history of infectious disease of the central nervous system (poliomyelitis, cerebrospinal meningitis, encephalitis, etc.); (2) history of spinal or intra-spinal disease (trauma or surgery of spinal column, intra-spinal canal mass, etc.); (3) systemic infection (sepsis); (4) skin or soft tissue infection at the site of epidural puncture; (5) coagulopathy. 4. presence of contraindications to vaginal delivery; 5. other reasons that are considered unsuitable for study participation.

Keywords: neuraxial labour analgesia neurodevelopmental delay
breathing & blood pressure

Conditions: Healthy; Overweight and Obesity

Summary: the purpose of this study is to determine the effect of obesity on cardiovascular responses during various breathing maneuvers.

adults with higher body mass can have trouble breathing during exercise, which could be due to high respiratory muscle workloads. these breathing muscles can require a lot of energy, which takes away energy from other (e.g., leg) muscles. participating in this study will help us understand how the heart and blood vessels respond during brief exercise and during various breathing maneuvers.

Eligibility criteria:
inclusion criteria: • body mass index values of ≤40 kg/m\^2 exclusion criteria: * not weight stable (\<5% change in body mass over the past six months) * overt cardiovascular, neurological, renal, liver, and/or metabolic illness (e.g., diabetes mellitus) * current, or history of uncontrolled, stage 2 hypertension (blood pressure \>140 / 90 mmhg; anti-hypertensive medications are permitted) * diagnosed obstructive sleep apnea * previous bariatric surgery * diagnosis or signs (e.g., values below the lower limit of normal) of overt airway disease(s) * current or recent (regular use within the past 6 months) use of tobacco or nicotine products (e.g., cigarettes, vaping) * per the powerbreathe® company: * patients who have undergone recent abdominal surgery and those with abdominal hernia. * asthma patients who have a very low symptom perception and suffer from frequent, severe exacerbations or with an abnormally low perception of dyspnoea. * if a patient is suffering from a ruptured eardrum or any other condition of the ear. * patients with marked elevated left ventricular end-diastolic volume and pressure. * patients with worsening heart failure signs and symptoms after a respiratory/inspiratory muscle training (imt) session * if you are suffering from a cold, sinusitis, or respiratory tract infection, we advise that you do not use your powerbreathe imt device. * individuals who are not yet adults (infants, children, teenagers) * pregnant (self-reported and urine pregnancy test conducted), lactating (self-reported), or post-menopausal (self-reported) females * prisoners
inspiring new science in guiding healthcare in turner syndrome registry

Conditions: Turner Syndrome

Summary: insights is a registry research study that collects key information on medical history for girls and women with turner syndrome and the clinical care they receive. this includes genetic tests, imaging, medications, and more for hundreds of patients seen at a number of clinics across the us. in addition to learning a lot about the current state of health for individuals with ts, insights serves as an infrastructure to conduct future studies are meaningful to patients and their families.


Eligibility criteria:
inclusion criteria: 1. individuals with ts and ts variants as defined by the ts clinical practice guideline definition (karyotype consistent with ts, phenotypic female, clinical feature(s) of ts) 2. informed consent/assent as appropriate exclusion criteria: a. lack of a ts diagnosis on file
does 3d laparoscopy improve vaginal cuff suture time?

Conditions: Uterine Fibroids; Abnormal Uterine Bleeding; Pelvic Pain; Adenomyosis

Summary: the objective aim is to evaluate whether the use of 3d laparoscopy facilitates the vaginal cuff closure of the vaginal cuff during a total laparoscopic hysterectomy among novice laparoscopists (pgy 2-4, fellow). this is a randomized single blinded controlled trial comparing the difference in 2d vs. 3d in regards to vaginal cuff closure time stratified by residents and fellows. patients will undergo a total laparoscopic hysterectomy and will be randomized to either 2d versus 3d.

this is a randomized single blinded controlled trial investigating 3d laparoscopy in the clinical setting. based on previous studies indicating 3d laparoscopy has improved skills of novice surgeons in the simulation lab, there has been no reports to date investigating the role of 3d laparoscopy in the operating room. our study will evaluate the facility of 3d laparoscopy in the novice surgeon, mainly residents and fellow. patients who present for a scheduled total laparoscopic hysterectomy will be randomized to either the standard 2d laparoscopy system or 3d laparoscopy system. stratifying residents versus fellow, we will compare the time to close the vaginal cuff comparing both systems.

Eligibility criteria:
inclusion criteria: * women with benign conditions such as uterine fibroids, menorrhagia, adenomyosis, pelvic pain, abnormal uterine bleeding exclusion criteria: * none

Keywords: laparoscopy 3d visual system total hysterectomy
cost-effectiveness study of the new nutrition screening tool cipa at hospital admission

Conditions: Malnutrition

Summary: objectives: to evaluate the cost-effectiveness of implementing a malnutrition screening tool "cipa" at the hospital universitario nuestra señora de la candelaria (hunsc), comparing the impact on health and the healthcare costs of hospitalised patients who are screened for malnutrition and of patients following standard clinical practice. methodology: the study will consist of a controlled trial on patients admitted to the internal medicine and general and digestive surgery wards at the hunsc. in both wards patients will be assigned to a control or to an intervention group. the control group will follow usual hospital clinical care, while the intervention group will be administered the screening tool "cipa" for early detection of malnutrition cases and they will be treated according to the screening results. the following variables will be evaluated: length of stay in hospital, mortality, readmissions and in-hospital complications. cost-effectiveness analysis will be undertaken measuring effectiveness by quality-adjusted life years (qalys). cost per patient will be measured by identifying health care resource utilisation, and the cost-effectiveness measure will be the incremental cost-effectiveness ratio (icer). investigators will calculate the incremental cost per qaly gained related to the intervention. this analysis will allow to quantify the costs (incurred and saved) related to the introduction of the malnutrition screening tool cipa in the hospital context and to measure the health impact of screened patients.


Eligibility criteria:
inclusion criteria: * formal consent to participate in the study. * patients admitted to the internal medicine or general surgery wards. exclusion criteria: * patients treated with nutritional support before cipa screening is performed. * patients transferred from other wards. * patients with an expected length of stay less than 72 hours. * cipa screening unfeasible for any reason. * patients with poor short-term prognosis. * bed destination at hospital admission nonrandomized. * patients participating in other investigation study. * pregnancy

Keywords: nutrition assessment inpatients cost-benefit analysis quality of life body composition mass screening
study of the efficacy and safety of quetiapine fumarate extended release (seroquel xr)

Conditions: Schizophrenia

Summary: this is an 8-week, multi-centre, open-label, non-comparative study to evaluate the efficacy and safety of quetiapine xr with daily dose 400mg-800mg used as mono-therapy in the treatment of acute schizophrenic patients. the eligible patient will be assigned to study treatment with quetiapine xr on day 1. please note: seroquel sr and seroquel xr refer to the same formulation. the sr designation was changed to xr after consultation with fda.


Eligibility criteria:
inclusion criteria: * documented clinical diagnosis meeting the diagnostic and statistical manual of mental disorders, 4th edition (dsm-iv) criteria * panss total score of at least 70 at enrolment and at assignment day 1 * cgi severity of illness score of at least 4 (moderately ill) at enrolment and at assignment day 1 and with worsening of the patient's condition during the 3 weeks exclusion criteria: * known intolerance or lack of response to quetiapine fumarate * administration of a depot antipsychotic injection within one dosing interval (for the depot) before assignment * substance or alcohol dependence at enrolment * opiates, amphetamine, barbiturate, cocaine, cannabis, or hallucinogen abuse by dsm-iv criteria within 4 weeks prior to enrolment

Keywords: acute schizophrenia panss
lifting and tightening of the face and neck following an increased density treatment

Conditions: Skin Laxity

Summary: the purpose of this study is to evaluate the ulthera® system for obtaining lift and tightening of the cheek tissue, reduction of jowling, and improving jawline definition and/or submental skin laxity when increased density treatment is applied.

all enrolled study subjects will receive one full face and neck ultherapy™ treatment. pre- and post-treatment photos will be taken. subjects will be required to return for follow-up visits at 60 days, 90 days, 180 days and 1 year following treatment.

Eligibility criteria:
inclusion criteria: * male or female, aged 30 to 65 years * subject in good health * desires lift and tightening of cheek tissue, reduction of jowling, improvement of jawline definition and/or submental skin laxity * understands and accepts the obligation not to undergo any other procedures in the areas to be treated through the followup period * willingness and ability to comply with protocol requirements, including returning for follow-up visits and abstaining from exclusionary procedures for the duration of the study exclusion criteria: * presence of an active systemic or local skin disease that may affect wound healing * severe solar elastosis * excessive subcutaneous fat on the cheeks * excessive skin laxity on the lower face and neck * significant scarring in areas to be treated * significant open facial wounds or lesions * severe or cystic acne on the face * presence of a metal stent or implant in the facial area to be treated, a pacemaker, or cochlear implants

Keywords: ulthera® system ultherapy™ treatment ulthera, inc.
dosage calculation for vitamin d treatment

Conditions: Deficiency, Vitamin D; Obesity

Summary: severe vitamin d deficiency can be treated with oral loading doses of cholecalciferol. our objective was to determine how to calculate the quantity of cholecalciferol needed for supplementation by single algorithm, usable on a patient-to-patient basis. we've conducted two studies. study 1 was done retroactively and included 88 patients treated for low vitamin d, 60 of those with a loading dose. the second study included 29 patients and aimed to test the validity of an algorithm based on data from study 1, which included patient bmi. both studies used oral loading doses and daily supplementation of cholecalciferol.


Eligibility criteria:
inclusion criteria: * severe hypovitaminosis d (25oh-vit.d \<25 nmol/l) exclusion criteria: * malabsorption * renal disease * other treatment with vitamin d related products * patients with a recent travel history with suspected increased sun exposure
evaluation of an ehealth system to reduce depression and increase resilience after sci

Conditions: Spinal Cord Injuries

Summary: the availability of symptom monitoring and self-management (smsm) interventions is especially important for civilians and military populations with spinal cord injuries (sci). high rates of depressive disorders (20-40%) and anxiety disorders (20-25%) have been found in both civilian and military populations and are significant contributors to both quality of life and well-being after sci. previous self-management interventions targeting physical activity and self-reliance in individuals with sci have demonstrated significant health and lifestyle benefits. however, it has been shown that the injured individual's psychological outlook and mood can either enable or hinder self-management efforts and that currently available sci-specific self-management programs may be inadequate. developing interventions to reduce mental health symptoms following sci is therefore critical to improve the lives of individuals, alleviate resource strain on military and civilian health care systems, and potentially reduce the rate of mortality by suicide in veterans and civilians living with sci. the current study will build on prior work developing an intervention platform to assess the effectiveness of this ehealth smsm system and will test the feasibility and effectiveness of the intervention platform.


Eligibility criteria:
inclusion criteria: * access to the internet and an internet-enabled device * diagnosis of a sudden-onset (i.e. not due to a degenerative disease such as als or ms) sci (either traumatic or non-traumatic) * discharged from initial inpatient rehabilitation and living in the community for at least 3 months * age 18 or older at the time of enrollment * age at least 16 years at the time of their spinal cord injury * current symptoms (no more than two weeks from the time of consent) of at least mild depression and/or anxiety, as determined by a score of ≥5 on the eight-item patient health questionnaire depression scale (phq-8) and/or seven-item generalized anxiety disorder measure (gad-7). exclusion criteria: * male and female participants younger than 18 years old * a lack of english proficiency needed to comprehend and complete study measures and review online study content. * current cognitive impairment that would limit comprehension of informed consent or study procedures, as determined by the member of the study team conducting informed consent. * lack of access to the internet and an internet-enabled computer or smart device. * a spinal cord injury that is due to a degenerative disease (e.g. als, ms) and not sudden onset.
impact evaluation of the 123 women emergency phone line in medellín, colombia

Conditions: Violence Against Women (VAW)

Summary: the purpose of this study is to determine whether the 123 women emergency phone line of medellin (colombia) leads to a reduction in the violence suffered by women, as well as in their psychological wellbeing and attitudes towards violence.

the purpose of this study is to determine whether the 123 women emergency phone line of medellin (colombia) leads to a reduction in the violence suffered by women, as well as in their psychological wellbeing and attitudes towards violence. there is excess demand for the 123 women emergency phone line of medellin. while on average 10 cases are reported (excluding referrals at night by the police, between 7pm and 7:00 a.m.), the average daily capacity of operation is 6 cases. so, is not possible for the 123 women team to track all women who call in 24 hours. women who cannot receive the services of the 123 women team only get the emergency support of the police and do not receive additional aid (while it is verified that the rights of women are respected and they are guided to relevant services). the excess of demand over the capacity of the team of the 123 women line represents a natural experiment. women will be recruited from those who are attended by the 123 emergency women phone line immediately as well as from those who were only attended by emergency support of the police and may have received later the support of the 123 women line (control group). in a first instance, women will be called to verify their address. a face to face survey will be conducted by mid-2015.

Eligibility criteria:
inclusion criteria: * women that call the 123 emergency line exclusion criteria: -
intervention effect of high definition transcranial alternating current stimulation (hd-tacs) on depressive disorder

Conditions: Transcranial Alternating Current Stimulation; Depressive Disorder

Summary: to investigate the intervention effect of high definition transcranial alternating current stimulation (hd-tacs) on suicidal ideation in patients with depressive disorder and its underlying neural mechanism by magnetic resonance imaging (mri) and electroencephalography (eeg).

forty patients with depressive disorder diagnosed by dsm-5 were recruited from the anhui mental health center and the first affiliated hospital of anhui medical university. all participants underwent a structured interview and routine laboratory examination before and after receiving high definition transcranial alternating current stimulation (hd-tacs) treatment after meeting the inclusion criteria and obtaining informed consent. each participant will complete the clinical evaluation, magnetic resonance imaging (mri), electroencephalography (eeg), and hd-tacs treatment conducted by trained researchers at the anhui mental health center. all the participants were randomized (1:1) to receive an "active hd-tacs" or "sham hd-tacs" treatment protocol. tacs: the central electrode was placed over f3 with return electrodes placed at fp1, fz, f7 and c3. fourteen 2-ma sessions (ramp-up and ramp-down periods of 15 and 15 seconds, respectively) were applied for 30 minutes per session, twice daily over 7 consecutive days, and the stimulus frequency was set as individual alpha frequency (iaf). sham hd-tacs was delivered using the same protocol and current intensity, but the period of active stimulation was only during the ramp-up and ramp-down periods of 15 and 15 seconds. before and after the treatments, the patients received a battery measure of neuropsychological tests, resting eeg, and mri scans in multimodalities. the neuropsychological assessment included hamd, madrs, bdi, hama, bss, c-ssrs, phq15, rrs, teps, pvaq, moca, stroop test, vft, dst, and avlt. multimodal mri includes 3d-t1, rs-fmri, and dti. the symptoms of the patients were followed up one and two months after the end of treatments.

Eligibility criteria:
inclusion criteria: * the patients were diagnosed by more than 2 psychiatrists and met the diagnostic criteria of dsm-5 for depression, and hamd\>17, bss\>6, phq-15\>5. * the age ranged from 18 to 65 years old, and the length of education was more than 5 years. * the visual acuity or corrected visual acuity is normal, right-handed, can cooperate with the completion of various experimental tests. exclusion criteria: * accompanied by severe somatic diseases, such as severe heart, liver, renal insufficiency and so on. * accompanied by other neurological diseases, such as stroke, epilepsy and so on. pregnant and lactating women. * accompanied by other mental disorders, such as drug abuse, schizophrenia, schizophrenic affective
a french survey of the diagnostic and therapeutic management of elderly people with histologically/cytologically confirmed lung cancer.

Conditions: ELDERLY PEOPLE; Non-small Cell Lung Cancer

Summary: management of lung cancer remains very controversial for elderly patients (pts) and they are often excluded from clinical trials. we present here a survey performed about the management of lung cancer pts aged 70 or more in france. all pts aged 70 or more with histo/cytologically proved lung cancer diagnosed between sept 02 and oct 03 in participating centers were recorded and their characteristics, the diagnostic procedures, therapeutic management and survival were analysed.


Eligibility criteria:
inclusion criteria: * histo/cytologically proved lung cancer exclusion criteria: -