Kornimate/medical-research-clean huggingface dataset:
a study of rucaparib versus physician's choice of therapy in participants with metastatic castration-resistant prostate cancer and homologous recombination gene deficiency

Conditions: Metastatic Castration Resistant Prostate Cancer

Summary: the purpose of this study is to determine how participants with metastatic castration-resistant prostate cancer, and evidence of a homologous recombination gene deficiency, respond to treatment with rucaparib versus treatment with physician's choice of abiraterone acetate, enzalutamide, or docetaxel.


Eligibility criteria:
inclusion criteria: * be 18 years old at the time the informed consent is signed * have a histologically or cytologically confirmed adenocarcinoma or poorly differentiated carcinoma of the prostate that is metastatic * be surgically or medically castrated, with serum testosterone levels of ≤ 50 ng/dl (1.73 nm) * be eligible for treatment with physician's choice of comparator treatment (abiraterone acetate, enzalutamide or docetaxel) * experienced disease progression after having received 1 prior next generation androgen receptor-targeted therapy * have a deleterious mutation in a brca1/2 or atm gene exclusion criteria: * active second malignancy, with the exception of curatively treated non melanoma skin cancer, carcinoma in situ, or superficial bladder cancer * prior treatment with any parp inhibitor * prior treatment with chemotherapy for metastatic castration-resistant prostate cancer * symptomatic and/or untreated central nervous system metastases * pre-existing duodenal stent and/or any gastrointestinal disorder or defect that would, in the opinion of the investigator, interfere with absorption of study drug

Keywords: crpc parp inhibitor parpi brca atm hrd triton homologous recombination dna repair dna defect dna anomaly germline somatic mcrpc
dexmedetomidine combined with bupivacaine for erector spinae plane block

Conditions: Posterior Lumbosacral Spine Fixation Surgeries

Summary: as the posterior lumbosacral spine fixation surgeries are common spine procedures done nowadays due to different causes and as this spine procedure is mostly accompanied with moderate to severe postoperative pain, so it is necessary to find an effective and efficient postoperative analgesia for patients with this surgery.


Eligibility criteria:
inclusion criteria: * elective posterior lumbosacral spine fixation and fusion surgery due to different causes that diagnosed clinically and radiologically including mri and plain x ray exclusion criteria: * hypersensitivity to the drugs used in the study \[local anesthetics, non-steroidal anti-inflammatory drugs, opioids and the drug under investigation (dexmedetomidine)\] * patients with any contraindication to regional anesthesia as skin infections at the site of the block * history of bleeding disorders or receiving anticoagulant medications
recombinant human leptin therapy effects on insulin action

Conditions: Type Two Diabetes Mellitus

Summary: leptin therapy improves insulin sensitivity in people with leptin-deficiency but it is not known whether it improves insulin action in persons who are not leptin deficient. the purpose of the present study was to determine whether leptin therapy has effects on insulin action in obese subjects with type 2 diabetes mellitus (t2dm). a randomized, placebo controlled trial was conducted in obese subjects with newly-diagnosed t2dm. subjects were randomized to treatment with placebo, low-dose, or high-dose leptin. insulin sensitivity was measured.

leptin therapy improves insulin sensitivity in people with leptin-deficiency but it is not known whether it improves insulin action in persons who are not leptin deficient. the purpose of the present study was to determine whether leptin therapy has weight loss-independent effects on insulin action in obese subjects with type 2 diabetes mellitus (t2dm). a randomized, placebo controlled trial was conducted in obese subjects with newly-diagnosed t2dm. subjects were randomized to treatment with placebo (saline), low-dose (30 mg/d), or high-dose (80 mg/d) recombinant methionyl human (r-met hu) leptin for 14 days. multi-organ insulin sensitivity before and after treatment was evaluated by using the hyperinsulinemic-euglycemic clamp procedure in conjunction with stable isotopically labelled tracer infusions to measure glucose, glycerol and fatty acid kinetics.

Eligibility criteria:
inclusion criteria: * diagnosed with type 2 diabetes for less than ten years * body mass index 25 - 40 * hemoglobin a1c 7.5% - 12.0% * fasting blood glucose between 90 and 240mg/dl exclusion criteria: * smoking * pregnancy * diabetes medications * regular exercise (more than 3 hours per week) * uncontrolled hypertension: systolic blood pressure greater than 160 or diastolic blood pressure greater than 95

Keywords: diabetes obesity
neoadjuvant mfolfoxiri for potentially resectable cholangiocarcinoma

Conditions: Cholangiocarcinoma

Summary: previous reports suggest benefit of neoadjuvant chemotherapy/chemoradiation treatment for borderline resectable cholangiocarcinoma. this study is a single center prospective phase ii study of neoadjuvant chemotherapy with mfolfoxiri in patients with borderline resectable cholangiocarcinoma.

previous reports suggest benefit of neoadjuvant chemotherapy/chemoradiation treatment for borderline resectable cholangiocarcinoma. this study is a single center prospective phase ii study of neoadjuvant chemotherapy with mfolfoxiri in patients with borderline resectable cholangiocarcinoma. this phase 2 trial was designed to enroll 25 patients with brcc who were assigned to mfolfoxiri neoadjuvant chemotherapy. the primary endpoint was the overall response rate.

Eligibility criteria:
inclusion criteria: 1. ≥ 18 years old at the time of informed consent 2. diagnosed with cholangiocarcinoma and the disease is measurable by recist 1.1 criteria 3. ecog performance status of 0 or 1 4. no distant metastasis 5. the disease is either resectable or potentially resectable 6. patients must have adequate organ function as defined by the following laboratory values at study entry: hemoglobin ≥ 8 g/dl (transfusions are acceptable) anc ≥ 1.5 x 109/l platelets ≥ 100 x 109/l ast/alt ≤ 3 x uln total bilirubin ≤ 2.5 mg/dl creatinine clearance ≥ 50 ml/min (estimated by cockcroft-gault or measured) 7. women of childbearing potential definition (wocbp) and men must agree to use adequate contraception prior, to study entry, for the duration of study participation, and 3 months after the end of treatment. 8. wocbp must have a negative serum or urine pregnancy test prior to initiation of treatment. exclusion criteria: 1. \> 75 years old 2. prior therapy for cholangiocarcinoma with either surgery, radiation or chemotherapy 3. other malignancies except for the following: adequately treated cervical carcinoma in situ and treated basal cell carcinoma. 4. hypersensitivity to 5fu, oxaliplatin (or other platinum agents), irinotecan (or to their excipients). 5. pregnant or lactating women. 6. psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule; those conditions should be discussed with the patient before registration in the trial. 7. liver disease including but not limited to cirrhosis, primary sclerosing cholangitis, future liver remnant of less than 20-30% 8. comorbidity including but not limited to active clinically serious infections, congestive heart failure, life-threatening arrhythmia 9. known hiv positive 10. baseline peripheral neuropathy/paresthesia grade ≥ 2.

Keywords: neoadjuvant potentially resectable chemotherapy bile duct cancer
barrett's esophagitis in anorexia nervosa binge/purge subtype

Conditions: Barrett Esophagus; Anorexia Nervosa, Binge Eating/Purging Type; Rumination; Vomiting; Eating Disorders; Esophageal Adenocarcinoma

Summary: to better define the presence of barrett's esophagus (be) via non-endoscopic testing in an eating disorder cohort with purging (vomiting/rumination) behaviors

a prospective cohort study to assess the presence of be in those with purging behaviors from their eating disorders has not been completed. there are multiple case reports describing a younger population not meeting typical screening guidelines whom developed this condition. to better define the presence of barrett's esophagus (be) via non-endoscopic testing in an eating disorder cohort with purging (vomiting/rumination) behaviors. individuals with severe forms of eating disorders with purging and ruminating behaviors not meeting the current screening guidelines for be will still test positive for be.

Eligibility criteria:
inclusion criteria: * patients diagnosed with an eating disorder diagnosis that includes purging history * ages 18-65 * purging history =\>5 years * purging or rumination at a minimum of once daily upon admission. * admission to the acute center for eating disorders and severe malnutrition exclusion criteria: * any eating disorder diagnosis that does not include purging behaviors * ages under 18 and over 65 * patients who otherwise meet the current acg screening guidelines (chronic gerd and 3 or more risk factors for barrett's mentioned in the background) * received mandated care at time of enrollment * inability to consent to participate in the research
accuracy of oximeters with hypoxia and methemoglobin or carboxyhemoglobin

Conditions: Healthy Volunteers

Summary: accuracy of the oximeter.

the conventional pulse oximeter has been a standard in clinical care for non-invasive hemodynamic monitoring, which only measures the arterial blood oxygenation. there are many clinical situations where tissue hypoxia may exist despite normal values obtained by conventional pulse oximeter. this can be cause by inadequate monitoring of oxygen demand (i.e. venous oxygen saturation) of the tissues. the existing method for venous blood oxygenation monitored is either through an invasive fiber optic catheter, or intermittently by blood sampling and co-oximetry. however, catheterization can be costly and can include inherent risks. therefore, due to the inherent risks of catheterization, venous oximetry is limited only to those critically ill patients. the clinical application of venous oximetry is numerous, including severe sepsis and septic shock, severe trauma and hemorrhagic shock, and heart failure and cardiac arrest. more complete information on patient hemodynamics can be provided by non-invasively monitoring of venous blood oxygenation.

Eligibility criteria:
inclusion criteria: * healthy volunteers between the ages of 21 and 49 years of either gender exclusion criteria: * smokers * pregnancy * any chronic medical condition including heart disease, hypertension, pulmonary disease, liver or kidney disease * obesity * evidence of abnormal neck vein anatomy
a study to measure the effect of brain stimulation on hand strength and function in patients with brain tumors

Conditions: Brain Tumor; Brain Cancer; Motor Cortex; Lesion

Summary: the neurosurgical standard of care for treating a patient with a tumor invading hand primary motor cortex (m1) includes performing a craniotomy with intraoperative direct electrical stimulation (des) mapping and to resect as much tumor as possible without a resultant permanent neurological deficit. however, the subjective nature of current intraoperative hand motor assessments do not offer a comprehensive understanding of how hand strength and function may be impacted by resection. additionally, there is a paucity of data to inform how altering des parameters may effect motor mapping. here, the investigators seek to demonstrate a feasible, standardized protocol to quantitatively assess hand strength and function and systematically assess several stimulation parameters to improve intraoperative measurements and better understand how cortical stimulation interacts with underlying neural function.


Eligibility criteria:
awake craniotomy cohort inclusion criteria: 1. age 18 - 75 2. ability to understand a written informed consent document, and the willingness to sign it 3. radiographic evidence of tumor on mri (i.e. non-enhancing) invading primary motor cortex in the non-dominant hemisphere. 4. karnofsky performance status (kps) ≥ 70 5. normal or near normal motor strength (i.e., at least 3/5 in relevant areas) 6. normal or near normal speech (can consistently name at least 4/5 cards) 7. free of other illness, in the judgment of the investigator, that may shorten life expectancy 8. willing and able to participate in all aspects of the study exclusion criteria: 1. presence of other malignancy not in remission 2. evidence of bi-hemispheric or widespread tumor involvement 3. medically high-risk surgical candidate 4. history of recent scalp or systemic infection 5. presence of other implants or foreign bodies in the head 6. inability to receive an mri for any reason 7. inability to receive cortical stimulation for any reason 8. presence of implanted cardiac device (such as a pacemaker or defibrillator)

Keywords: brain stimulation cortex stimulation hand motor cortex primary motor cortex m1 resection surgery healthy volunteers hand strength hand function
upper extremity pattern exercises and respiratory functions

Conditions: Healthy Individuals

Summary: the study will be carried out with healthy students between the ages of 18-25 years who are studying at ege university faculty of health sciences, department of physiotherapy and rehabilitation and who voluntarily agree to participate in the study. informed consent form will be signed before the evaluation of the individuals. the study will be carried out as a single group with the inclusion of a total of 20 individuals. the students who volunteered to participate in the study will actively apply the selected pnf upper extremity patterns for 4 weeks and will be evaluated twice, before and after the application. demographic information of the individuals; age, height, weight, gender, background, surname, smoking habit, alcohol habit, education level (class), sports habit, covid-19 disease status and when it occurred will be recorded. cosmed pulmonary function test device will be used to evaluate the respiratory function of the individuals, oncomed brand electronic body weight and height measurement device will be used to calculate the body mass index. body image perception scale will be used for body image perception, beck depression inventory will be used to evaluate psychological status, and rosenberg self-esteem scale will be used to evaluate sense of self.


Eligibility criteria:
inclusion criteria: * not diagnosed with any chronic disease * no neurological problems * has not had covid-19 for at least 6 months exclusion criteria: * diagnosed with respiratory system diseases * regular medication use * suspected pregnancy * individuals with rheumatic or neurological diseases

Keywords: reathing exercises body image depression proprioceptive neuromuscular facilitation
optimization of drug treatment in hospitalized elderly (omage)

Conditions: Global Medical Assessment of Elderly Frail Patients

Summary: a randomized trial has been designed to determine if this complex intervention can significantly decrease the risk of unplanned readmissions in this very elderly population, compared with usual care.

drug treatment in elderly is not yet optimal. 20 to 30% of admissions of elderly aged over 80 are related to drug problems, most of them being preventable. to decrease drug related hospitalizations need iatrogenic prevention, compliance improvement, and underuse decrease. a multifaceted intervention has been designed, included three dimensions : 1/ drug optimization 2/ patient and/or caregiver education and 3/ better coordination with home health professionals before discharge. a randomized trial has been designed to determine if this complex intervention can significantly decrease the risk of unplanned readmissions in this very elderly population, compared with usual care.

Eligibility criteria:
inclusion criteria: * patients hospitalized as a matter of urgency in unity(unit) of geriatrics acute * patients of more than 70 years old * hospitalization in the unity(unit) of geriatrics foreseen(planned) superior acute in 5 days * enlightened assent writing and signed * preliminary medical examination exclusion criteria: * patients in scheduled(programmed) hospitalization * patient in palliative care * patient whose vital forecast is engaged(opened) in 3 months * patient already include during a previous hospitalization patient already included in a study concerning the therapeutic care * followed medical impossible (refusal of care, absence of alive regular, patient doctor abroad) * not membership to a regime of social security or cmu * patient not speaking french

Keywords: frail elderly patient education drug optimization underuse vulnerable drug related hospitalization medical intervention
a single-center retrospective study to find prediction factors related to mortality of covid-19 patients.

Conditions: COVID-19

Summary: in the single-centered, retrospective study, 306 hospital patients (including 129 diabetes and 177 non-diabetes patients) confirmed with sars-cov-2 infection were enrolled in tongji hospital, wuhan, china. clinical characteristics including clinical manifestation, laboratory parameters, lung ct features and clinical outcomes were compared between diabetes and non-diabetes patients. the prediction factors were analyzed for mortality of covid-19 by univariate and multivariate analysis.


Eligibility criteria:
inclusion criteria: patients admitted from feb 2, 2020 to feb 15, 2020, diagnosed with sars-cov-2 pneumonia according to interim guidance of national health commission of the people's republic of china. exclusion criteria: with sars-cov-2 rna detection negative results.
best method of burn wound care: a prospective randomized trial

Conditions: Burns

Summary: the purpose of this study is to better understand how to best care for burn wounds.

participants: patients presenting to kamuzu central hospital in lilongwe malawi with burn wounds occuring within 72 hours of admission. procedures (methods): this is a prospective randomized trial. subjects will be randomized during admission to receive either open dressing care or closed dressing care of their burn wounds.

Eligibility criteria:
inclusion criteria: * burn wound admitted to the hospital * signed informed consent * burn wound occuring within 72 hours of admission exclusion criteria: * language other than chichewa or english * inability to access of phone (required for follow-up)

Keywords: burns wounds and injuries bandages
effect of aged garlic extract (age) on improving coronary atherosclerosis in people with type 2 diabetes mellitus

Conditions: Coronary Arteriosclerosis; Endothelial Dysfunction; Type 2 Diabetes Mellitus

Summary: the purpose of this research study is to see the effect of taking aged garlic extract (age) on the progression of coronary plaque, a condition called atherosclerosis, in people diagnosed with diabetes.

this clinical trial is to determine on progression rates of low attenuation plaque under influence of aged garlic extract as compared to placebo over the 1year period in individuals with type 2 diabetes mellitus.the study also examines the effect of aged garlic extract on endothelial function and arterial stiffness which was measured by cardio-ankle vascular index (cavi) over the 3months period.

Eligibility criteria:
inclusion criteria: * age 30-75 years * known diabetes mellitus (hga1c \>6.5%, fasting blood sugar \>125 mg/dl, taking anti- diabetes medications) * subjects must provide written informed consent after the scope and nature of the investigation has been explained to them * calcium score \>20 at baseline exclusion criteria: * a contraindication to age including: known hypersensitivity to drug. * any unstable medical, psychiatric or substance abuse disorder that in the opinion of the investigator or principal investigator is likely to affect the subject's ability to complete the study or precludes the subject's participation in the study * weight in excess of 350 pounds * bleeding disorder * history of known coronary artery disease, myocardial infarction, stroke or life- threatening arrhythmia within the prior six months * nyha class ii- iv heart failure * history of malignancy within the last 5 years (other than skin cancer) or evidence of active cancer which would require concomitant cancer chemotherapy * serum creatinine \> 1.4 mg/dl * triglycerides \> 400 at visit 1 * drug or alcohol abuse, or current intake of more than 14 standard drinks per week * concurrent enrollment in another placebo-controlled trial * partial ileal bypass or known gastrointestinal disease limiting drug absorption * current tobacco use * current use of anticoagulants (except for anti-platelet agents) * renal failure * history of hypertensive encephalopathy or cerebrovascular accident * hematological or biochemical values at screening outside the reference ranges considered as clinically significant in the opinion of the investigator or pi * pregnancy

Keywords: coronary artery disease endothelium
milking of the cut-cord during resuscitation of preterm infants (the mocc study)

Conditions: Preterm Infant

Summary: in this feasibility study, the investigators will randomize preterm infants born at \<32 weeks gestation to either the standard practice of delayed cord clamping (dcc) for 30-60 seconds at birth or milking of the long-cut cord (mocc) while providing resuscitation/stabilization to the infant. the main objectives of the trial are to assess the feasibility of the new approach (mocc) and to compare the two groups regarding the hemoglobin levels on admission to nicu in addition to neonatal morbidity and mortality.


Eligibility criteria:
inclusion criteria: * preterm infants \<32 weeks' gestation exclusion criteria: * clinical evidence of interrupted placental circulation (placental abruption or avulsed cord) or bleeding from placenta previa. * monochorionic twins or any higher order multiple pregnancy * major fetal congenital or chromosomal abnormality * documented fetal anemia or in utero red blood cell transfusion * intent to withhold or withdraw treatment of the infant

Keywords: preterm infant delayed cord clamping cord milking resuscitation