Kornimate/medical-research-clean huggingface dataset:
disposable 7.5fr electronic flexible ureteroscope combined 10fr ureteral access sheath for treatment of renal stone <2cm

Conditions: Ureteroscopy; Urolithiasis

Summary: observation efficacy and safety of disposable f7.5 electronic flexible ureteroscope combined f10 ureteral guide sheath for treatment of renal stone \<2cm.

using disposable 7.5fr electronic flexible ureteroscope combined 10fr ureteral guide sheath to treat renal stone \<2cm, and investigating its efficacy and safety.

Eligibility criteria:
inclusion criteria: 1. patients with kidney stones less than 2cm who choose to perform "flexible ureteroscopic holmium laser lithotripsy"; 2. over 18 years old, male or female; 3. no hydronephrosis or mild to moderate hydronephrosis (collection system separation is less than 2cm); 4. the subject has no mental illness or language dysfunction, can understand the situation of this study and has signed an informed consent form, and is estimated to be able to cooperate with the completion of the entire study; 5. no urinary tract infection or no clinical manifestations of urinary tract infection; 6. patients with urinary tract infection, negative urine culture, and no fever need to undergo antibiotic treatment for more than 3 days; urinary routine examination suggests urinary tract infection, positive urine culture, and patients without fever need to undergo antibiotic treatment for more than 7 days, till the urine culture turns negative. exclusion criteria: 1. patients with a previous history of ureteral stenosis or who have undergone open, laparoscopic ureteral, nephrectomy and lithotripsy; 2. fever or urinary tract infection is not treated according to the inclusion criteira; 3. pregnant women and women's menstrual periods; 4. cannot tolerate anaesthesia or surgery due to serious systemic diseases, heart disease, lung insufficiency and failure of important organs; 5. anatomical malformations such as polycystic kidneys, horseshoe kidneys, and ectopic kidneys; 6. patients with high suspicion of ureteral stenosis or diseases that are considered unsuitable to participate in this clinical study; 7. patients indwelling double j stent preoperatively; 8. patients who need bilateral upper urinary tract surgery at the same time.

Keywords: flexible ureteroscope ureteral guide sheath
effects of high-intensity aerobic training on balance, walking capacity, and quality of life in patients with sub-acute stroke.

Conditions: Stroke

Summary: stroke is one of the major cause of morbidity and mortality and the leading cause of disability in adults all around the world. stroke survivors can suffer several neurological impairments and deficits which have an important impact on patient's quality of life and which increase the costs for health and social services. after stroke, impairments in adls and functional status, deterioration in health related quality of life can be seen. the purpose of this study is to determine the effect of high intensity speed based treadmill training on balance, walking capacity and quality of life in sub-acute stroke.


Eligibility criteria:
inclusion criteria: * age 40-80 years; first episode of stroke; \>4 weeks of stroke onset; hemiparesis resulting from unilateral ischaemic stroke; ashworth score of 0 or 1, indicating no spasticity or slight spasticity over the affected lower limb, respectively; mini-mental state examination score ≥23; ability to perform independent walking for at least five minutes with or without an assistive device (fac=3). all patients will be determined to be in stable cardiovascular condition with a low although slightly greater risk for vigorous exercise than for apparently healthy persons (class b according to the american college of sports medicine \[acsm\]).13 exclusion criteria: * participants will be excluded from the study if they had any of the following: (1) chronic cardiorespiratory or metabolic diseases; (2) severe osteoporosis; and (3) lesions pertaining to the brainstem or cerebellum; (4) having resting blood pressure above 160/100 mmhg even after taking medications; (5) cardiovascular comorbidity (aortic stenosis, depression of st-segment, heart failure, arrhythmias, unstable angina, hypertrophic cardio-myopathy); (6) transient ischemic attack; (7) by-pass surgery in the recent three months; and (8) other musculoskeletal problems that prevented the participants from doing aerobic activity.

Keywords: cerebrovascular accident aerobic exercise high intensity interval training
trauma services intervention to prevent violence

Conditions: Skin Injury Due to Violence; Gunshot Wound, Contact

Summary: primary outcome: research participants and their network contacts will be followed over 6 months to assess whether a social work case management protocol results in reduction of trauma services recidivism and criminal violence arrests.

allegheny county, pa continues to suffer between 100-120 homicides each year, with perhaps 2-3 times as many gunshot injuries that require hospitalization. firearm homicides overwhelmingly affect african american men aged 15-35. building on prior efforts in violence prevention, the investigators propose to launch a hospital trauma service intervention that will take advantage of a "teachable moment" in the emergency room. all four hospitals providing level i trauma services in allegheny county have agreed to host the program, an evidence-based effort developed by the national network of hospital violence intervention (nnhvi). adaptation of the nnhvi model will focus on the social networks of gunshot victims as well as the victims themselves. intervention efforts will range from job training and mentoring to relocation to different communities. the investigators will offer the opportunity to participate in the research and receive the intervention to all gunshot victims identified in county level i trauma services. participants in the research protocol will be asked to recruit their high-risk social network members for the intervention.

Eligibility criteria:
inclusion criteria: 1. age 18+ 2. gunshot victim treated and discharged from level i trauma facility; or member of social network of gunshot victim who may be high risk of firearm violence - exclusion criteria: 1. gunshot wound because of suicide attempt 2. gunshot wound because of non-violent episode (e.g., hunting accident) 3. unable to participate in research interview because of cognitive deficit 4. planning to leave community as result of shooting 5. discharged from trauma service to prison 6. unable to provide informed consent -

Keywords: violence firearm guns homicide trauma injury
role of curarization during anesthesia for gynecologic surgical laparotomy procedures

Conditions: Curarization, Postoperative Residual

Summary: the primary outcome of this study is to investigate whether deep nmb reversed with sugammadex is superior to moderate nmb reversed with neostigmine, in terms of overall pain in the first 48 hrs after laparoscopic gynecologic surgery, reversal time from nmb (tof≥0.9) and direct and indirect costs. additionally we will also assess: drugs consumption for pain and antiemetics (rescue dose), surgical conditions, hemodynamic and respiratory stability, operation time, anesthesia time, total amount and flow rate of co2, insufflation time, resolution of post-operative ileus, dry mouth and ponv in the first 48 hours, patient satisfaction


Eligibility criteria:
inclusion criteria: * age 18-75 years bmi between 16 and 40 kg/m2 ecog performance status tra 0 e 1 american society anesthesiologist (asa) class 1 or 3 able to provide informed consent to trial procedures exclusion criteria: * age \ 75 years * bmi \ 40 kg/m2 * ecog performance status \>1 * pregnancy * active or recent pelvic inflammation * anticipated airway difficulty * patients with history of allergy to rocuronium, neostigmine or sugammadex * allergy to nsaids * previous opioids consumption for chronic pain * patients receiving drugs for different medical conditions, that may prolong or shorten the duration of rocuronium effect (e.g aminoglycosides, magnesium) * hepatic or renal failure * persistent coagulopathy * neurological or cognitive disorders * conversion from laparoscopic to open surgery onset of intraoperative complications
prescribing opioid pain relievers in the emergency department: understanding and optimizing the encounter

Conditions: Opioid Use, Unspecified

Summary: the investigators overall study objective is to improve patients knowledge and safe use of opioid pain relievers upon discharge from the emergency department.

recent studies indicate that emergency department (ed) discharge processes - including written and spoken communications - are inadequate, and patients often leave without the knowledge necessary to properly care for themselves. in the context of opioid pain relievers, this lack of knowledge is potentially dangerous, as patients may not possess the requisite knowledge for safe use of their medication or an awareness of the dangers of medication misuse. the aim of this study was to evaluate the impact of an opioid information sheet and spoken counseling on patient knowledge about opioids and safe use behaviors. the investigators conducted a randomized controlled pilot test of a dual-modality educational intervention (written information sheet and spoken counseling about opioids) to assess if the intervention can increase patient knowledge about opioid pain relievers. these activities were intended to guide future modification of educational interventions and the future development of best practices for emergency physician spoken counseling about opioid pain relievers.

Eligibility criteria:
inclusion criteria: * prescribed an opioid pain reliever * english speaking exclusion criteria: * non-english speaking * clinically unstable, psychologically impaired or intoxicated as judged by the research staff member. * chronic opioid use, defined as daily or near daily use of opioid pain relievers for the past 90 days. * admitted to hospital * unable to complete follow up phone interview in 4 - 7 days.

Keywords: opioids health literacy
predicting the probability of return to work after injury

Conditions: Trauma

Summary: to evaluate return to work (rtw) status after moderate and major trauma in hong kong at one year after injury. to derive reliable prediction models for return to work.

background: trauma is a leading cause not only of death worldwide but also of disability, and in hong kong it ranks sixth as a cause of death for all age groups. the implementation of trauma systems has improved the survival of injured patients in many settings including hong kong. however, the aim of trauma care for the injured person is not only to prolong life but also to restore patients to the best possible health status, and where applicable, to return to work. survivors of trauma often experience late sequelae that have a major impact on almost all aspects of everyday life, and improvements in functional outcome and health status may continue for at least five years post-injury. objectives: 1. to evaluate return to work (rtw) status after moderate and major trauma in hong kong at one year after injury; 2. to derive reliable prediction models for rtw. study design: this is a multi-centre, prospective long-term follow up cohort study of the 1163 trauma patients admitted to the prince of wales hospital (pwh), queen elizabeth hospital (qeh) and tuen mun hospital (tmh) in hong kong in 2017-2018. patients will be recruited within four weeks of ed attendance as soon as the patient is clinically stable and conscious. the follow-up period for return to work status of the 1163 trauma patients will extend from baseline to one year after trauma.

Eligibility criteria:
inclusion criteria: * aged 18 years or above * eligible for the trauma registry * working or seeking employment before injury exclusion criteria: * isolated hip or pathological fractures * injury severity score (iss) of 1 * patients who are unwilling to enter the study * patients who have left hong kong

Keywords: return to work status functional outcome quality of life
relationship between gestational diabetes and type 2 diabetes

Conditions: Gestational Diabetes; Type 2 Diabetes

Summary: the overall objective of this research project is to study the impact of preventive practices on the t2d-related risk profile among women with and without prior gdm and their children exposed and unexposed to gdm.

type 2 diabetes (t2d) is a growing public health problem owing to its prevalence as well as its high morbidity and mortality rates. the identification of high-risk populations is of great importance particularly because the onset of t2d can be prevented or delayed by lifestyle modifications. among high-risk populations, women with previously diagnosed gestational diabetes mellitus (gdm) are at particularly high risk of developing t2d. the success in reducing the occurrence of t2d among women with previous gdm could be achieved only if appropriate preventive measures are undertaken. according to the american diabetes association (ada) and the canadian diabetes association (cda), lifestyle modifications aimed at reducing body weight and increasing physical activity are recommended and women are encouraged to be breastfeeding their infants. certain factors have been suggested as determinants of behavioral practices in women with prior gdm including cognitive and environmental factors. a better understanding of these issues is essential for developing effective preventive strategies and possibly reducing the prevalence of t2d in the population. moreover, in utero exposure to maternal impaired glucose tolerance or diabetes may increase the risk of developing overweight or diabetes in offspring. since march 2012 we thus test the presence of childhood metabolic alterations predictive of future t2d in gdm-exposed and unexposed offspring and investigate environmental factors during the postnatal period that are associated with prevention of metabolic alterations.

Eligibility criteria:
inclusion criteria: * women aged ≥18 years with or without a diagnosis of gdm in the past 3-12 years and their children. exclusion criteria: * pregnant women, women with type 1 diabetes.

Keywords: gestational diabetes type 2 diabetes
risk factors of medistinal metastasis in endoscopic staging of lung cancer

Conditions: Non Small Cell Lung Cancer

Summary: the purpose of this study is to investigate risk factors for mediastinal lymph node metastasis in potentially operable non-small cell lung cancer in order to find indications for endoscopic mediastinal staging. chest ct, integrated pet/ct, and endobronchial ultrasound guided transbronchial needle aspiration (ebus-tbna) +/- endoscopic ultrasound with bronchoscope-guided fine needle aspiration (eus-b-fna) are performed for mediastinal staging. ct and pet/ct findings, histologic types and other risk factors will be analyzed. the investigators develop the prediction method for mediastinal metastasis.


Eligibility criteria:
inclusion criteria: * histologically confirmed or strongly suspected non-small cell lung cancer (nsclc) * potentially operable exclusion criteria: * m1 disease * inoperable t4 disease * mediastinal infiltration or extranodal invasion of the mediastinal lymph node visible on chest ct * confirmed supraclavicular lymph node metastasis * pancoast tumours * t1 ground glass opacity nodule (with solid part 1\<cm) * solid t1 (1\<cm)n0 m0 by ct \& pet/ct * inoperable patients (after evaluating medical and surgical operability) * patients who refused surgical treatment * contraindications for bronchoscopy * drug reaction to lidocaine, midazolam, fentanyl * pregnancy

Keywords: endobronchial ultrasound ebus-tbna lung cancer staging
validation of haguide software module accuracy in mapping stn boundaries in parkinson's disease patients who underwent dbs procedure

Conditions: Parkinson Disease; Deep Brain Stimulation

Summary: haguide version 1.0 (neuro-omega ltd.) is a software module add-on to the fda cleared neuro-omega system (k123796). it was designed to facilitate the use of neuro-omega's system by automatically mapping visually the depth of stn landmarks intra-operatively. haguide algorithm computes and displays the stn entry and exit, as well as introduces a detection of a distinct dlor-vmnr boundary. haguide visual display is added to the ui and it is supplementing and not replacing the previously cleared standard display (visual and audio) of the system.


Eligibility criteria:
inclusion criteria: 1. patient was diagnosed with parkinson's disease; 2. patient underwent implantation of dbs electrode in the stn for the treatment of parkinson's disease, using the neuro-omega device for navigation; 3. procedure's mer digital recorded data is available; exclusion criteria: 1. dbs performed for any other movement disorder other than parkinson's disease including parkinsonism; 2. the recording has a high intensity of noise that will not allow re-analysis using the haguide software, in such cases the haguide software indicates that the signal is not valid for analysis; 3. missing data for primary end-point on the respective patient medical chart; 4. the collected data that is used for the validation is with high step size resolution;

Keywords: parkinson disease deep brain stimulation microelectrodes recording haguide alpha omega engineering ltd.
progressive exercise after total knee arthroplasty (tka)

Conditions: Osteoarthritis

Summary: total knee arthroplasty (tka) is performed more than 7.000 times a year in finland most often for osteoarthritis (oa). while pain is predictably reduced, function does not typically ever reach that of age-matched, uninjured subjects. quadriceps weakness has been implicated in the development and progression of knee oa and is a significant problem after tka. advance to return to normal daily activities is not sufficient to restore knee function or quadriceps strength after tka. the aim of this study is to assess the effectiveness of progressive exercise program restoring knee strength, mobility and improving the functional outcome after primary tka.

many studies have shown, that after tka pain decreased significantly, but muscle strength of the operated knee did not recover and may stay under the preoperative level. to find out the effects of progressive exercise program the investigators will perform, 6 weeks after tka, a randomized clinical trial of lower extremity strength training using two subgroups of people: traditional exercise group and progressive exercise group.

Eligibility criteria:
inclusion criteria: * primary unilateral tka for knee osteoarthritis exclusion criteria: * rheumatoid arthritis * fibromyalgia * bilateral tka * heart or lung disease, which prevent training * unstable serious disease (cancer) * reduced cooperation (drug, alcohol abuse, mental illness)

Keywords: osteoarthritis knee total knee arthroplasty exercise
in vitro/in vivo correlation (ivivc) for oral slow release (sr) tablets pramipexole in healthy male volunteers

Conditions: Healthy

Summary: the primary objective of the study was to estimate the magnitude of the error in the prediction of in vivo bioavailability (auc0-30,cmax) by means of in vitro dissolution data applying the methods of ivivc. the secondary objective of the study was to investigate whether the intake of food 30 minutes prior to drug administration affects the systemic exposure of pramipexole sr c2 or not


Eligibility criteria:
inclusion criteria: * healthy male subjects as determined by results of the screening * signed written informed consent in accordance with good clinical practice (gcp) and local legislation * age ≥ 18 and ≤ 50 years * bmi ≥ 18.5 and ≤ 29.9 kg/m2 exclusion criteria: * hypersensitivity to pramipexole or to other dopamine agonists * supine systolic blood pressure lower than 110 mmhg and supine diastolic blood pressure lower than 60 mmhg at screening * any finding of the medical examination (including blood pressure, pulse rate and ecg) deviating from normal and of clinical relevance * gastrointestinal, hepatic, renal, respiratory, cardiovascular, metabolic, immunological or hormonal disorders * diseases of the central nervous system (such as epilepsy) or psychiatric disorders or neurological disorders * history of orthostatic hypotension, fainting spells or blackouts * chronic or relevant acute infections * history of allergy/hypersensitivity (including drug allergy) which is deemed relevant to the trial as judged by the investigator * intake of drugs with a long half-life (\> 24:00 hours) within at least one month or less than ten half-lives of the respective drug before enrolment in the study or during the study * use of any drugs which might influence the results of the trial up to 7 days prior to enrolment in the study or during the study * participation in another trial with an investigational drug (≤ two months prior to administration or during the trial) * smoker (\> 10 cigarettes or \> 3 cigars or \> 3 pipes/day) * inability to refrain from smoking on in-house trial days * alcohol abuse (\> 60 g/day) * drug abuse * blood donation (≥ 100 ml within four weeks prior to administration or during the trial) * any laboratory value outside the clinically accepted reference range * excessive physical activities within the last week before the trial or during the trial
minimal invasive approach for surgical repair of rib fractures with a novel intrathoracic device

Conditions: Rib Fracture Multiple

Summary: a retrospective review of demographics and adverse events from cases completed with the ribfix advantage system. evaluation of device integrity, and performance by a prospective ct scan with a minimum of 3 months post-implantation.

the ribfix advantage system is a novel intrathoracic titanium plating system that is fda-cleared for the treatment of rib fractures. the ribfix advantage system is designed to be implanted in a less invasive procedure where plates are introduced and placed on the pleural cortex of the rib during video-assisted thoracoscopic surgery. intrathoracic plate placement allows for smaller cutaneous incisions and less muscle disruption, which may aid in patient recovery compared to traditional open reduction internal fixation systems that are currently available. the purpose of this study is to gather the first clinical data on this novel device in the context of a case series of patients with radiologic and quality-of-life follow-up.

Eligibility criteria:
inclusion criteria: * male or female * ≥ 18 years old (no upper limit) * underwent surgical repair of rib fracture(s) with the ribfix advantage system alone or in combination with other systems for fracture repair * signed informed consent form for participation in a clinical trial * willing and able to return for a follow-up visit (includes a computed tomography (ct) scan of the chest) exclusion criteria: * off label use of ribfix advantage (e.g., active or latent infection at the time of implantation, sepsis, metal sensitivity)

Keywords: multiple rib fractures chest stabilization rib plates