Kornimate/medical-research-clean huggingface dataset:
efficacy and safety of esarin gel in chronic venous insufficiency and varicose veins

Conditions: Chronic Venous Insufficiency; Varicose Vein; Superficial Vein Thrombophlebitis

Summary: evaluation efficacy and safety of esarin gel in subjects with chronic venous insufficiency or varicose veins combine superficial vein thrombophlebitis.

open-label,non-controlled study design with three visits (pre-treatment/baseline, treatment day 14 and day 28). administered esarin gel twice daily for 28 days in subjects with chronic venous insufficiency rated between ceap 0 and 3 or varicose veins combine superficial vein thrombophlebitis, in comparison to the pre-treatment.

Eligibility criteria:
1. inclusion criteria: * patients of both sexes, aged above 20 years old. * the patient has confirmed his/her willingness to participate in the study, after being informed about all the aspects of the study that might be relevant for his/her decision to participate, and has signed and dated the informed consent form, as approved by the institutional review board/ ethics committee (irb/ec). * presence of chronic venous insufficiency which is rated between functional classes ceap 0 and 3.(ceap classes: c0:no visible or palpable signs of venous disease, c1:telangiectasies or reticular veins. c2 :apparent varicose veins, c3 :edema) * diagnosed with superficial vein thrombophlebitis and have skin reaction by redness, swelling, fever and pain symptoms. 2. exclusion criteria: * known allergy to the product's ingredients * pregnant or breastfeeding * patient is joining to any other clinical trail * patient has not sign the informed consent form * deep vein thrombosis * cellulitis * stasis dermatitis * the patient is taking non-steroids anti-inflammatory drugs( include oral ,topical creams or patch form)
a study of the safety and efficacy of microplasmin to induce a posterior vitreous detachment (mivi iii)

Conditions: Vitrectomy

Summary: a multicenter study to compare multiple doses of intravitreal microplasmin in patients undergoing surgical vitrectomy.


Eligibility criteria:
inclusion criteria: * patients in whom vitrectomy is indicated exclusion criteria: * posterior vitreous detachment (pvd) present at baseline * vitreous hemorrhage * certain vitreoretinal conditions including proliferative disease, rhegmatogenous retinal detachment, and proliferative vitreoretinopathy (pvr) * have had a vitrectomy in the study eye at any time
immunogenicity and safety of adimflu-s 2011-2012 in non-elderly adult and elderly subjects

Conditions: Influenza

Summary: the purpose of this study is to evaluate the antibody response to each of the three influenza vaccine strains included in the licensed seasonal flu vaccine, as measured by hemagglutination inhibition (hai) at 21 days post immunization in non-elderly and elderly subjects in compliance with the requirements of the current european union (eu) recommendations for the evaluation of the immunogenicity for a new formulation of a licensed flu vaccine (cpmp/bwp/214/96).


Eligibility criteria:
inclusion criteria: * males or non-pregnant females and aged ≥ 18 years; * willing and able to adhere to visit schedules and all study requirements; * subjects read and signed the study-specific informed consent. exclusion criteria: * subject or his/her family is employed by the participated hospital; * subjects received 2010-2011 seasonal influenza vaccine within the previous 6 months; * history of hypersensitivity to eggs or egg protein or similar pharmacological effects to study medication * personal or family history of guillain-barré syndrome * an acute febrile illness within 1 week prior to vaccination; * current upper respiratory illness, including the common cold or nasal congestion within 72 hours * subjects with influenza-like illness as defined by the presence of fever (temperature ≥ 38°c) and at least two of the following four symptoms: headache, muscle/joint aches and pains (e.g. myalgia/arthralgia), sore throat and cough * female subjects who are pregnant during the study * treatment with an investigational drug or device, or participation in a clinical study, within 3 months before consent * immunodeficiency, or under immunosuppressive treatment * receipt of any vaccine within 1 week prior to study vaccination or expected receipt between visit 1 (study vaccination) and visit 2 (final collection of blood samples); * receipt of any blood products, including immunoglobulin in the prior 3 months; * underlying condition in the investigators' opinion may interfere with evaluation of the vaccine

Keywords: influenza vaccine immunogenicity
study of the difference between anorexia nervosa with a history of psychological trauma and classical anorexia nervosa on the neurocognitive and neurophysiological factors

Conditions: Anorexia Nervosa

Summary: recent studies suggest that patients with an history of trauma may represent a specific subtype of anorexia nervosa (am) underlined by specific neurobiological and psychopathological mechanisms. thus, am-t subjects would manifest cognitive (specific difficulties in executive functions), emotional (emotional disruption, impulsivity, etc.) and neurobiological (secretion of kynurenine and neurokinins in the face of stress) caracteristics different from those of am subjects.

we will recruit a total of 100 patients with a diagnosis of anorexia nervosa in the university hospital of montpellier : 50 patients with an history of psychological trauma and 50 patients without any history of psychological trauma participation consists of a half-day visit. patients will perform clinical and neuropsychological assessments and an exposition test. during this test, participants will be exposed, for 7 minutes, to neutral, positive or negative emotional photos. heart rate variability will be determined through a biopac mp160 before, during and after this event. saliva samples to measure kynurenin, tryptophan, substance p and neurokinin-1 will be collected before and directly after the test.

Eligibility criteria:
inclusion criteria common to the 2 groups am-t and am-c : * women patient * present a diagnosis of anorexia nervosa according to the dsm-5 criteria * between 18 and 65 years old * present a bmi\> 14 * do not present a sight problem or be corrected appropriately by wearing glasses or contact lenses. * be affiliated to a social security scheme, or beneficiary of such a scheme * be able to understand the nature, purpose and methodology of the study inclusion criteria specific to patients in the am-t group: - to have answered at least one of the grayed out items of the lec-5, that is to say to have answered "it happened to me" to at least one of the items 1 to 13 or to item 16 "and / or having answered" i witnessed it "to at least one of items 14 and 15. inclusion criteria specific to patients in the am-c group: - not having answered "it happened to me" or "i witnessed it" to one of the items of lec-5 exclusion criteria: * present a severe unstable mental pathology in the opinion of the investigator * present active suicidal ideation * have consumed psychoactive substances in the last 24 hours before the assessment * present a severe major depressive episode incompatible with the assessment, in the opinion of the investigator. * present in the opinion of the investigator an unstable somatic state (eg severe metabolic disorder making it impossible or likely to impair the reliability of neuropsychological and cardiac evaluations). * take a drug treatment acting on the cardiovascular system * refusal of the patient * be protected by law (tutorship or curatorship). * to be deprived of liberty by administrative decision.

Keywords: anorexia nervosa psychological trauma heart rate variability kynurenine substance p
serum interleukin - 17a in juvenile idiopathic arthritis

Conditions: JIA

Summary: 1. this study aims to determine the serum levels of interleukin-17a (il-17a) in children with juvenile idiopathic arthritis (jia) 2. analyze the correlation between il-17a values and disease activity, certain clinical features, and laboratory markers of inflammation.

juvenile idiopathic arthritis (jia) is a group of chronic heterogenous disorders that manifests as joint inflammation in patients aged \<16 years and lasts longer than 6 weeks. globally, approximately 3 million children and young adults are suffering from jia with prevalence rates consistently higher in girls. the prevalence of jia in africa and middle east was observed to be towards the lower range of the global estimate. (1) the precise cause and pathogenesis of jia are unknown; however, genetic, environmental, and autoimmune factors are hypothesized to play a role in its development. (2) the condition can affect one or more joints and cause systemic symptoms such as fever or rash, as well as extra-articular inflammatory signs such as uveitis.(3) the il-17 cytokine superfamily is composed of 6 structurally related cytokines, namely il-17a-f. the most investigated member of the family is il-17a. it is synthesized by th17 cells, γδ-t cells, nk t cells, lymphoid tissue inducer-like cells, paneth cells, and neutrophils. il-17a plays important roles in protection from bacterial and fungal infections and in the development of autoimmune diseases (4) recently, a number of studies have been conducted on the role of il-17a in the development of chronic arthritis. it has a role both at the initial stages of joint inflammation and in the destruction of joint cartilage and bone structures.(5) it binds to its receptors on synoviocytes, endothelial cells, fibroblasts and osteoblasts and stimulates production of pro-inflammatory cytokines, chemokines and other inflammatory mediators, and also, interacts synergistically with other pro- inflammatory cytokines such as il-1, il-6, and tumor necrosis factor alpha.(6)

Eligibility criteria:
inclusion criteria:_ patients less than 16 years at onset of disease and diagnosed with oligoarticular and polyarticular jia, fulfilling the ilar classificationcriteria of jia. * control group will include age-and-sex-matched apparently healthy children. exclusion criteria: • patients having associated neurological or disabling diseases. * patients with diabetes mellitus, acute or chronic infections. * patients with another causes of arthritis other than jia.
identification of predictive and prognostic markers for lung cancer with metastases

Conditions: Lung Cancer; Primary Tumor; Metastases

Summary: the project aims to compare the histopathological and molecular characteristics of tumour tissue from metastases with similar analyses of the primary tumour in the lung, where it is available. the investigators will therefore perform analysis of blood samples if possible, to identify predictive markers in blood samples.

the investigators want to make genome analysis of tissue samples. this involves analysing the rna, dna methylation, for example in cancer cells. this will provide information regarding somatic changes in cancer cells, such as mutations. all of the investigators analysis will be cancer-focused, with the goal of increasing understanding of the heterogeneity. the investigators will therefore perform analysis of blood samples if possible, to identify predictive markers in blood samples. this will then be the mirna, rna expression or protein expression in blood samples.

Eligibility criteria:
inclusion criteria: * patients with metastasizing lung cancer where further treatment is still applicable. exclusion criteria: * terminal patients or patients in a reduced general condition with egoc 3-4, i.e. patients who are confined to bed more than 50% of the day, with no clinical indication to perform sampling of the tumor and metastases. * patients where further cancer treatment is no longer applicable. * patients with cognitive impairment. * patients with inaccessible metastases where sampling may cause distress to the patient and are at increased risk of complications.

Keywords: molecular pathology functional genomics lung cancer primary tumor metastases
yoga in older cardiac patients

Conditions: Cardiovascular Diseases in Old Age

Summary: the goal of this clinical trial is to compare, at 3 months, the effects of a yoga intervention on physical health, including balance, muscle strength, physical activity levels, cardiac autonomic function, and physical vulnerability, as well as psychological health, including depressive symptoms and anxiety, in cardiac patients who are older than 65 years old and randomized to the intervention or control group. the main questions aim to 1) determine if yoga can improve physical health outcomes such as balance, muscle strength, cardiac function, and physical vulnerability in older adults with cardiovascular disease, and 2) determine if yoga can positively impact psychological health, including reducing depressive symptoms and anxiety in this population. participants in the intervention group will attend yoga sessions twice a week for three months. the intervention group will be asked to complete surveys and physical function assessments at the beginning and three months later. researchers will compare the intervention group and the control group to see if there is any difference and improvement in physical and psychological health between the two groups.


Eligibility criteria:
inclusion criteria: * have a history of an acute myocardial infarction within the preceding year, stable angina, cardiac surgery (including heart transplantation, valve surgery, or coronary artery bypass), coronary artery angioplasty or stents, or heart failure (ejection fraction \< 35%) diagnosed in the past year * have completed facility-based cardiac rehabilitation program (phase cr-ii) within 12 months * can read and understand english * have no major comorbidities limiting their ability to participate in a yoga intervention * reside in kentucky. exclusion criteria: * have incapacitating neurologic, orthopedic, or neoplastic conditions such as stroke paralysis, terminal cancer, or a cognitive disorder * currently practice yoga * have no home wiifi access

Keywords: physical activity yoga mind-body therapies
pre-screening study to identify mtap loss in advanced solid tumors or lymphoma

Conditions: Advanced Solid Tumors; Lymphoma

Summary: the purpose of this study is to identify subjects with advanced solid tumors or lymphoma in which the methylthioadenosine phosphorylase (mtap) protein has been lost.

study ag270-ps-001 is a pre-screening study to identify subjects with advanced solid tumors or lymphoma in which the mtap protein has been lost. subjects whose tumor tissue has lost the mtap protein may be considered for future enrollment into a phase 1 clinical study of an experimental drug, ag-270, that is designed to inhibit the growth of tumors lacking this protein. identification of the loss of mtap will rely solely on the evaluation of archival tumor tissue samples by ihc. this study is therefore non-interventional

Eligibility criteria:
inclusion criteria: 1. be ≥18 years of age. 2. have a histologically confirmed diagnosis of an advanced solid tumor (other than a primary cns malignancy) or lymphoma. 3. have archival tumor tissue that can be provided for assessment of mtap deletion status. 4. have given written informed consent to participate in this study. exclusion criteria: 1. have a primary cns malignancy (eg, gbm). 2. have a medical or psychological condition deemed by the investigator likely to interfere with the subject's ability to give informed consent or participate in the study.
development and validation of a serum biomarker for the diagnostic work-up of asthma

Conditions: Asthma; Biomarkers

Summary: serum samples of asthmatic patients will be screened for serum biomarkers


Eligibility criteria:
inclusion criteria: * 18 - 65 years * physician-diagnosed asthma exclusion criteria: * no clear asthma phenotype * presence of other pulmonary diseases (chronic obstructive pulmonary disease, alfa-1-antitrypsine deficiency emphysema, immunoglobulin e deficiency, allergic bronchopulmonary aspergillosis) * \> 15 pack years * no sputum available * respiratory infection * other inflammatory diseases (rheumatoid arthritis, colitis ulcerosa)
the acute effects of static and pnf stretching exercise with blood flow restriction in athletes

Conditions: Athletes

Summary: the study aims to examine the acute effects of static and proprioceptive neuromuscular facilitation stretching exercises with blood flow restriction on hamstring flexibility, muscle strength, and single leg hop in athletes. outcome measures were hip range of motion, isometric and eccentric hamstring muscle strength, and single leg hop distance.

a total of 109 athletes were included in the study. participants were randomized into five groups: (1) static stretching, (2) proprioceptive neuromuscular facilitation (pnf) stretching, (3) blood flow restriction (bfr) + static stretching, (4) bfr + pnf stretching, and (5) control groups. stretching exercises were performed on the dominant leg hamstring muscle group for 3 sets of 15 seconds each. bfr was applied during the stretching to the blood flow restriction (bfr) + static stretching and bfr + pnf stretching groups. no stretching was applied to the control group. assessments were performed at baseline and immediately after stretching. hamstring flexibility (hip joint range of motion) was assessed via the passive straight leg raise test. isometric and eccentric hamstring muscle strength were measured using a hand-held dynamometer, and muscle power was assessed using the single leg hop distance.

Eligibility criteria:
inclusion criteria: * age between 18-40 years old * engaged in regular physical activity for at least 8 hours a week for the last 6 months * body mass index (bmi) \< than 30 kg/m² * momentary blood pressure less than 135/85 mmhg exclusion criteria: * history of fractures or surgical operations involving the lower limbs, hips, or lumbar region * history of fractures, surgeries and other diagnosed medical conditions on the lower extremity, hip, and lumbar region * systemic musculoskeletal disease * pain in the lower back, hips, or lower extremities * known hip deformity or diagnosis of scoliosis * history of deep vein thrombosis or embolism * diagnosis of circulatory system diseases such as hypertension or peripheral vascular disease * history of anemia * previous cerebrovascular disease or myocardial infarction.

Keywords: blood flow restriction, stretching, flexibility, hamstring
the effect of pth(1-84) or alendronate on reduction of back pain in postmenopausal women with an osteoporosis related vertebral fracture(s) (fp-005-im)

Conditions: Back Pain

Summary: the primary objective of this trial is to show that pth(1-84) is superior to alendronate in reducing back pain intensity over a 24-week treatment period in postmenopausal women with an osteoporosis related vertebral fracture(s). secondly the objectives are to investigate any differences in patient reported outcomes between the two treatment arms over a 24-week treatment period in postmenopausal women with an osteoporosis related vertebral fracture(s).


Eligibility criteria:
inclusion criteria: * postmenopausal women with a t-score ≤ -1.5 sd and at least one osteoporosis related vertebral fracture. chronic back pain. exclusion criteria: * previous/current treatment and medical history.

Keywords: postmenopausal women back pain osteoporosis related fracture
(tap) block vs. systemic lidocaine: effects on recovery

Conditions: Pain; Surgery

Summary: it has been demonstrated that female patients have poor quality of surgical recovery compared to male patients. increased sensitivity to pain and increased susceptibility to postoperative nausea and vomiting have been attributed as causal factors. currently, few strategies have been shown to improve quality of recovery in female patients undergoing laparoscopic hysterectomy. a better recovery in female patients undergoing outpatient laparoscopy is particularly desirable since those patients do not have access to potent intravenous medications and nursing support after hospital discharge. our group has previously demonstrated that both tap block and systemic lidocaine improve quality of recovery after outpatient laparoscopic gynecological surgery. the tap block, however, requires expertise, equipment (ultrasound), and additional time to perform as compared with a simple lidocaine infusion. it is currently unknown if a systemic lidocaine infusion provides non-inferior quality of recovery when compared to tap block for outpatient laparoscopic gynecological surgery. the main objective of the current investigation is to examine the effect of tap block on quality of recovery compared to a systemic lidocaine infusion. we hypothesize that systemic lidocaine infusion would provide non-inferior quality of recovery when compared to tap block for outpatient laparoscopic gynecological surgery. significance: this is the first study to compare systemic lidocaine to tap block with regard to quality of recovery. the research question; does systemic lidocaine provide similar quality of recovery as tap block for outpatient laparoscopy? the hypothesis; systemic lidocaine provides non-inferior quality of recovery as tap block for outpatient laparoscopy. research significance: it has been shown that females have poor surgical recovery compared to males; this project intends to demonstrate that systemic lidocaine provides similar recovery as tap blocks but it does not require the expertise, equipment, and time needed to perform tap blocks.


Eligibility criteria:
inclusion criteria: * age: 18-65 years of age * surgery type: outpatient gynecological laparoscopy * asa status: i and ii * fluent in english exclusion criteria: * history of allergy to local anesthetics * history of chronic opioid use * pregnant patients * drop out: conversion to open surgery, patient or surgeon request.

Keywords: anesthesiology pain tap block gynecology postoperative analgesia