Kornimate/medical-research-clean huggingface dataset:
add-on nighttime bracing in adolescent idiopathic scoliosis

Conditions: Scoliosis

Summary: bracing is an accepted standard therapy for idiopathic scoliosis at cobb angle ranges between 25° and 45°. however, it is unclear, if a specifically tailored regimen of daytime and nighttime braces (=double brace) yields superior results compared to the standard treatment (single brace for day and night). these two treatment regimens were investigated in the study.

one-hundred-fifteen patients with adolescent idiopathic scoliosis (ais) were assessed before initiation of bracing treatment and at the final follow-up 2 years after deposition of the brace. they were divided into two groups: double-brace group and single-brace group. each patient underwent clinical and radiological examinations and cobb angles were measured.

Eligibility criteria:
inclusion criteria: * ais * age between 10 and 15 years (y) * risser's sign of 0-2 * cobb curvature angle of 25-40° * no previous treatment * compliance (at least 23 h wearing time) exclusion criteria: * non-idiopathic scoliosis * cobb curvature angle \>40° * \ 15 years for initial treatment

Keywords: scoliosis nighttime bracing full-time bracing chêneau brace charleston brace
safety and efficacy of amphotericin b lipid complex in the treatment of cryptococcal meningitis in patients with the acquired immunodeficiency syndrome

Conditions: Meningitis, Cryptococcal; HIV Infections

Summary: to evaluate the safety, tolerance and efficacy of three different dosage regimens of amphotericin b lipid complex (ablc) compared to fungizone (amphotericin b) in patients with aids and cryptococcal meningitis.


Eligibility criteria:
inclusion criteria concurrent medication: allowed: * intravenous pentamidine for treatment of pneumocystis carinii pneumonia (pcp) but not for prophylaxis. patients must have the following: * meet the cdc criteria for diagnosis of aids. * confirmed episode of acute cryptococcal meningitis. * informed consent of the patient or guardian prior to entry. exclusion criteria co-existing condition: patients with the following conditions or symptoms are excluded: * clinical evidence of acute or chronic meningitis due to an agent other than cryptococcus neoformans. * history of hypersensitivity/anaphylactoid reaction attributed to amphotericin b. * any other concomitant condition which, in the opinion of the investigator, would preclude a patient's participation in the study. concurrent medication: excluded: * corticosteroids. * salicylates or other drugs known to interfere with prostaglandin synthesis except as specified in protocol. * zidovudine. * investigational agents. * interferon. * interleukin-2 (il-2). * steroids. * isoprinosine. * intrathecal amphotericin b. * intravenous pentamidine pcp prophylaxis (only treatment). patients with the following are excluded: * clinical evidence of acute or chronic meningitis due to an agent other than cryptococcus neoformans. * history of hypersensitivity/anaphylactoid reaction attributed to amphotericin b. * inability to obtain appropriate follow-up visits. * any other concomitant condition which, in the opinion of the investigator, would preclude a patient's participation in the study. prior medication: excluded within 4 weeks of study entry: * amphotericin b. * excluded within 2 weeks of study entry: * any other experimental drug.

Keywords: meningitis liposomes cryptococcosis acquired immunodeficiency syndrome amphotericin b chemistry, pharmaceutical
influencing factors of helicobacter pylori infection and eradication failure

Conditions: Helicobacter Pylori Infection

Summary: helicobacter pylori (h. pylori) is closely related to the occurrence of gastric cancer and other diseases, the discovery and eradication of h. pylori infection has great significance to the prevention and treatment of related diseases. at the same time,understanding the influencing factors of h. pylori infection and eradication failure in the population can provide a scientific basis for the formulation of local h. pylori prevention and control strategies. so, the investigators intend to analyze the factors related to h. pylori infection and eradication failure in the outpatients of gastroenterology clinics in xi'an, china.

taking 300 permanent residents in xi'an area who will go to the gastroenterology clinic of the second affiliated hospital of xi'an jiaotong university from february 2022 to march 2023 and undergo 13c-ubt examination as the research object. a questionnaire survey on factors related to h. pylori infection and eradication failure will be conducted. the questionnaire includes basic information, eating patterns, living environment, related gastrointestinal symptoms, etc. among the outpatients, h. pylori-positive patients will be given rabeprazole 10 mg + amoxicillin 1000 mg + clarithromycin 500 mg + colloidal bismuth tartrate 220 mg bid for 14 days. after 4-6 weeks of completing eradication therapy, 13c-ubt will be performed to determine whether h. pylori is eradicated. according to the results of 13c-ubt at the beginning and results of 13c-ubt after eradication treatment, outpatients will be divided into three groups: h. pylori negative group, h. pylori positive radical cure successful group and h. pylori positive radical cure failed group. next using spss 19.0 statistical software analyzes h. pylori infection and eradication failure related influencing factors. according to the analysis, the investigators can provide a scientific basis for local formulation of correct and effective h. pylori prevention and control strategies.

Eligibility criteria:
inclusion criteria: 1. perform 13-ubt, 2. be able to understand the content of the questionnaire and answer the questions accurately, 3. permanent residents of xi'an area, 4. no previous hp eradication treatment, 5. agree to join the group and sign the informed consent form, 6. aged between 18-70. exclusion criteria: 1. complicated with serious cardiovascular, respiratory, blood, liver, kidney, nerve or endocrine system diseases, 2. mental disease, 3. gastric or esophageal surgery history, 4. severe atypical hyperplasia of gastric epithelium, gastric malignant tumor or other malignant diseases 5. pregnant or lactating women, 6. patients with history of penicillin allergy, 7. allergy to rabeprazole, bismuth dose, clindamycin, 8. have taken proton pump inhibitors,h2 receptor antagonists, within 2 weeks before participating in the inspection, 9. have taken herbs that have bacteriostatic effect or antibiotic or bismuth agents within 4 weeks before participating in the inspection.

Keywords: helicobacter pylori infection risk factor questionnaire
efficacy and safety study of bimatoprost 0.01% alone compared with travoprost 0.004% and timolol 0.5% in subjects with glaucoma or ocular hypertension

Conditions: Glaucoma; Ocular Hypertension

Summary: this efficacy and safety study will evaluate lumigan® .01 (bimatoprost 0.01%) alone compared to travatan z® (travoprost 0.004%) and timolol gfs, 0.5% (timolol 0.5% ophthalmic gel forming solution) in patients who require iop lowering therapy.


Eligibility criteria:
inclusion criteria: * ocular hypertension or glaucoma that requires treatment with medication * have a best corrected visual acuity (bcva) of 20/100 or better in both eyes exclusion criteria: * history of lasik, lasek, rk, and/or prk in the study eye(s) * history of any intraocular surgery or glaucoma laser surgery in the study eye(s) within 3 months * use of topical, periorbital, intravitreal or systemic steroid within 3 months or expected use during the course of study
efficacy and safety of desferal versus osveral in transfusional iron overload

Conditions: Thalassemia; Iron Overload; Transfusion Related Complications

Summary: thalassemic patients often suffer from iron overload due to frequent blood transfusion. oral iron chelators reduce iron overload in transfusion dependent patients. the aim of this study is to compare the efficacy and safety of osveral and desferal in transfusional iron overload patients with β-thalassemia and intermediate thalassemia in bandarabbas.

this is a double blinded randomized controlled trial on efficacy and safety of osveral and desferal in thalassemic patients.

Eligibility criteria:
inclusion criteria: * confirmed intermedia or major thalassemia * more then 2 years old * serum ferritin level \> 1000 * normal creatinine and complete blood count (cbc) exclusion criteria: * hcv, hbv or hiv positive patients

Keywords: thalassemia iron overload transfusion osveral desferal
blood pressure in the emergency department

Conditions: Blood Pressure; Hypertension; Emergencies

Summary: this is a cohort study based on a large sample (\> 600 000) of emergency department (ed) visits from two university hospital eds. information on incident disease after discharge from the ed will be collected through linkage to swedish national in-patient register and cause of death register. the importance of blood pressure measured at the ed for incident atherosclerotic cardiovascular disease during long term follow up will be studied by cox-regression analysis


Eligibility criteria:
inclusion criteria: * attending the emergency departments (ed) at karolinska university hospital in solna or huddinge during the specified time period * record of blood pressure measurement from the ed-visit exclusion criteria:

Keywords: blood pressure emergency department atherosclerotic cardiovascular disease myocardial infarction stroke long-term prognosis
genetic studies of strabismus, nystagmus, and associated disorders

Conditions: Strabismus; Nystagmus, Congenital

Summary: strabismus (misalignment of the eyes) often runs in families. in this study, the investigators are looking for genetic variants associated with strabismus and nystagmus. three types of subects will be enrolled: (1) families with at least 3 members with strabismus, (2) individuals with infantile esotropia and their parents and siblings, and (3) individuals with infantile nystagmus and their parents. whole exome and/or whole genome sequencing will be used to identify genetic variants shared by family members with strabismus and to identify genetic causes of nystagmus.


Eligibility criteria:
inclusion criteria: - member of a family with at least 3 biological relatives with strabismus. (both affected and non-affected family members will be enrolled). or - member of a family with at least 1 individual with infantile esotropia. (both affected and non-affected family members will be enrolled). or - member of a family with at least 1 individual with infantile nystagmus. (both affected and non-affected family members will be enrolled). exclusion criteria: * paralytic strabismus in affected family members

Keywords: strabismus esotropia exotropia nystagmus
evaluating the efficacy of gpt-based nutrition and diabetic counseling in gestational diabetes management: a randomized controlled trial (aim-gdm)

Conditions: Gestational Diabetes

Summary: the purpose of this study is to assess whether an ai based counseling service can be beneficial for patients to assist in management of gestational diabetes.

gestational diabetes mellitus (gdm) affects approximately 6-9% of pregnancies globally, posing significant risks to both maternal and neonatal health. standard management includes dietary counseling, glucose monitoring, and insulin therapy when necessary. however, the rising prevalence of gdm and limited healthcare resources necessitate innovative solutions to supplement traditional care. generative pre-trained transformers (gpts), a type of large language model (llm), offer personalized, real-time counseling and support. recent advancements in ai have shown promise in various healthcare applications, but the efficacy of gpt-based counseling in gdm management remains underexplored. this study builds on preliminary evidence suggesting that ai can enhance patient engagement and outcomes, aiming to validate these findings in a controlled trial. the integration of ai, specifically gpts, into healthcare can revolutionize patient management by providing continuous, tailored support. this study aims to evaluate whether gpt-based counseling can improve glycemic control and patient satisfaction in gdm management, compared to traditional counseling alone. by placing ai within the context of prenatal care, this research seeks to address gaps in current gdm management practices and offer scalable, personalized solutions.

Eligibility criteria:
inclusion criteria: * women aged 18-45 * diagnosed with gdm in pregnancy * able to use a smartphone * fluent in english or spanish exclusion criteria: * pre-existing diabetes * high-risk pregnancies due to other medical conditions * inability to consent * non-english and/or non-spanish speakers * no smartphone access
walking training in peripheral artery disease (grenada sub-study)

Conditions: Peripheral Artery Disease; Intermittent Claudication

Summary: whereas the efficacy of exercise interventions has been abundantly proven in male with peripheral artery disease (pad), it remains to be determined whether these interventions are effective in women. the aim of this randomized controlled trial which will be performed with 34 pad women will be to investigating the effects of 12 weeks of supervised walking on functional capacity and cardiovascular function and regulation at rest and during exercise.


Eligibility criteria:
inclusion criteria: * aankle-brachial index (abi) ≤ 0.9 in one or two legs * fontaine stage ii of pad * body mass index \<35 kg/m2 * resting systolic blood pressure (bp) \<160 mmhg and diastolic bp \<105 mmhg * ability to walk at least 2min at 3.2 km/h * ability to undertake an incremental treadmill test * decrease of at least 15% in abi after a maximal treadmill test * not currently engaging in any regular exercise program exclusion criteria: * exercise induced signs of myocardial ischemia or complex ventricular arrhythmias * cardiovascular autonomic neuropathy * use of beta-blocker, nondihydropyridine calcium antagonists or insulin and hormone replacement therapy.
bioequivalency study of zolpidem tartrate under fed conditions

Conditions: Insomnia

Summary: the objective of this study was the bioequivalence of a roxane laboratories' zolpidem tablets, 10 mg, to ambien® tablets, 10 mg (sanofi-synthelabo inc.) under fed conditions using a single-dose, randomized, 2-treatment, 2-period, 2-sequence crossover design.


Eligibility criteria:
inclusion criteria: * no clinically significant abnormal findings on the physical examination, medical history, or clinical laboratory results during screening. exclusion criteria: * positive test for hiv, hepatitis b, or hepatitis c. * treatment with known enzyme altering drugs. * history of allergic or adverse response to zolpidem or any comparable or similar product.
a study examining effects of apples/ apple products on heart disease risk

Conditions: Cardiovascular Disease

Summary: this study will examine if health benefits of consuming nutrient-rich apples, an apple extract and freeze dried apple product will be similar. 50 volunteers at increased risk of heart disease will consume either a low apple diet (\<1 portion/d), 2 high or low polyphenol apples/day, an apple extract, or freeze dried apple granule product for 4 weeks (ten participants per group, randomly assigned). apart from the extract group, all volunteers will consume a placebo. all volunteers will follow a low apple diet (\<1 apple per day) other than what has been provided by the research team. volunteers will complete food diaries at the start and end of the study and a number of questionnaires. blood and urine samples collected at 0 and 4 weeks

many products (such as bioactive extracts) attempt to replicate health benefits of a diet rich in fruit and vegetables, however, it is not known whether similar health benefits can be gained from consuming these processed products. a placebo-controlled intervention study will examine if health benefits are similar between products. volunteers will have one risk factor for heart disease. recruitment will be by advertisement from qub and general public. apples/apple products will be provided for the 4 weeks, but otherwise volunteers' normal diet and lifestyle will be followed. blood and urine samples will be collected at week 0 and week 4. 4-day food diaries will be completed at the start and end of the study. a number of questionnaires (physical activity, lifestyle, levels of liking, tolerability to study products, study evaluation) will be completed at the start and end of the study. as this is a pilot study, power calculations were not considered appropriate. statistical analysis will be carried out in spss, each endpoint of interest from the week 0 measure will be compared between the five intervention groups by one way analysis of variance.

Eligibility criteria:
inclusion criteria: * \> 50 years old or * current smoker or * systolic blood pressure 120-139mmhg/ diastolic blood pressure 80-89mmhg or * total cholesterol \>5.2mmol/l or hdl cholesterol \<1.03mmol/l or * bmi \>25 kg/m2 exclusion criteria: * diabetes mellitus * an acute coronary syndrome or transient ischaemic attack within the past 3 months * special dietary requirements, food sensitivities or vegetarian/ vegan diet by choice * oral anticoagulation therapy * bmi \>35 kg/m2 * excessive alcohol consumption (\>28 u/week men or \>21 u/week women) * pregnancy/ lactation * taking antioxidant supplements * medical conditions or dietary restrictions that would substantially limit ability to complete the study requirements

Keywords: high epicatechin apples low epicatechin apples apple extract apple granules blood pressure cholesterol
determination of protocol of nocturnal food intake of shift workers.

Conditions: Shift Work Type Circadian Rhythm Sleep Disorder

Summary: this study evaluates the effect of different dietary conducts in the nocturnal period on the postprandial metabolism and food perceptions of night workers of the hospital of clinics of uberlândia, federal university of uberlândia.

due to imbalances in the circadian rhythm, shift workers may present inadequate eating habits, which provoke metabolic and nutritional disorders. in this crossover study the participants consumed, at different times and separated by 6 days interval, two meals pre-established at the time of night work: a control and a higher-protein. on the day of each intervention, the participants were evaluated for response of blood and subjective markers after meal (glucose, insulin, triglycerides and subjective perceptions related to ingestion after each meal). it is expected that the standardization of a glycemic reduction diet will improve the metabolic response of the workers, demonstrated in the results of the biochemical parameters. if this scenario is confirmed, it is still expected that the data and results obtained in this study may serve as subsidies for the elaboration of nutritional interventions consistent with the work routine at night.

Eligibility criteria:
inclusion criteria: * male workers; * age between 20 and 60 years; * have been working night shift for at least six months; * sedentary. exclusion criteria: * failure to provide the information or material necessary for the development of the study; * carriers of diseases previously diagnosed and under treatment, such as type 2 diabetes mellitus, hypertension, cardiovascular diseases and related mood disorders such as depression.

Keywords: food intake sleep shift work postprandial metabolic response
evaluation of acceptability and satisfaction of hemophilia patients treated with fusengo

Conditions: Hemophilia A

Summary: this study aims to investigate prospectively throughout a period of 3- 6 months and not to exceed 12 months (according to local therapeutic plans) patients experiences of treatment with factor viii in the new device named fusengo, a new delivery system for factor viii compared to their previous delivery system.


Eligibility criteria:
inclusion criteria: * male adults (aged 18 to 65 years) with haemophilia a (all severity levels) who currently use fviii treatment either prophylactically or on-demand using traditional factor viii delivery mechanisms. * patients advised for any reason by their physician to switch to a new factor viii delivery device, namely fusengo, before receiving any details about this study or patients who requested to be treated with a new factor viii delivery device namely fusengo, before receiving any details about this study. exclusion criteria: * patients not previously recommended by their physician to switch to this new factor viii delivery system or patients who did not previously ask their physician to be switched to this new factor viii delivery system. * patients for which it is anticipated that 10 infusions will not occur in the 12 months following their inclusion in the study.
survey in patients with chronic adrenal insufficiency in germany

Conditions: Adrenal Insufficiency; Addison's Disease

Summary: the purpose of this survey is to assess patients with chronic primary or secondary adrenal failure regarding subjective health status, incidence and causes of adrenal crisis, hormone replacement regimens and concomitant endocrine or non endocrine disease.


Eligibility criteria:
inclusion criteria: * age \> 18 years * chronic adrenal failure with disease duration \> 12 months and hormone replacement therapy for cortisol deficiency exclusion criteria: * adrenal insufficiency due to adrenocortical carcinoma * ai due to long-term pharmacological glucocorticoid treatment * glucocortiocid doses above 7.5 mg prednisolone equivalent for other reasons than ai

Keywords: adrenal insufficiency subjective health status quality of life adrenal crisis hormone replacement dhea