Kornimate/medical-research-clean huggingface dataset:
glossopharyngeal nerve block on post tonsillectomy pain among egyptian children

Conditions: Post Tonsillectomy Pain

Summary: tonsillectomy is one of most common performed surgical procedure in children . tonsillectomy or adenotonsillectomy have high incidence of post operative pain , it is very important and significant problem because it can lead to decrease oral intake and dehydration

tonsillectomy is one of the most common performed surgical procedure in children. tonsillectomy or adenotonsillectomy have high incidence of post operative pain incidence . there is still debate about the optimal analgesia for this common procedure , different methods have been described including intraoperative anesthetic pain regimens , adjustment of surgical technique , intraoperative local anesthetic injection and use of pharmacotherapy post operative . the main goal of the preventive analgesia is the pain releif with minimum side effect . the objective of this study is to investigate and compare the effect of glossopharyngeal nerve block for relief of pain on children following adenotonsillectomy . this is prospective , double blinded , randomized study

Eligibility criteria:
inclusion criteria: * average weight is 10_50 kg * patient is generally stable * indication of tonsillectomy is recurrent tonsillitis * ability to self report pain exclusion criteria: * hypersensitivity to bupivacaine * obstructive sleep apnea syndrome * pulmonary or cardic diseases

Keywords: glossopharyngeal nerve block
maternal psychopathology and offspring mental health (psi_per)

Conditions: Intergenerational Relations

Summary: pregnant women consecutively referred to the perinatal psychiatric outpatient department, those in charge of the psychiatric outpatient department and pregnant healthy controls from the general population will be recruited on a voluntary basis. mothers will be tested with the epds, bai, bdi, whoqol, scid ii and ctq; their children will be tested with the cbcl between 18 months and 5 years.

in order to attest possible psychic outcomes in offspring of mothers affected by psychiatric disorders due to maternal psychopathology (with an in-depth evaluation about the role of maternal personality disorders), the investigators recruit all the women consecutively referred and admitted to the perinatal psychiatric outpatient department from january, 2011 to december, 2016, due to the manifestation of psychic suffering during pregnancy. during their first appointment, patients are routinely administered the structured clinical interview for dsm-iv axis ii disorders (scid ii), childhood trauma questionnaire (ctq), world health organization quality of life instruments (whoqol-bref), edinburgh postnatal depression scale (epds), beck depression interview (bdi) and beck anxiety interview (bai). the mini-international neuropsychiatric interview (m.i.n.i.) is used to confirm clinical diagnosis. as a control samples, the investigators recruited pregnant patients belonging to the outpatients psychiatric department who did not have psychiatric issues linked to their pregnancy or in the relationship with their children and pregnant healthy controls among the general population, with no history of mental health issues. controls were tested as the clinical sample. all the patients will be asked to complete a caregiver report form, the child behavior checklist (cbcl), once their children were at least 18 months old.

Eligibility criteria:
inclusion criteria: pregnancy; adequate comprehension; acceptance on a voluntary basis. exclusion criteria: incapacity; acute psychosis.

Keywords: personality disorders anxiety disorders mood disorders
genetic testing for breast, ovarian, pancreatic, and prostate cancers

Conditions: Breast Cancer; Ovarian Cancer; Pancreatic Cancer; Metastatic Prostate Cancer

Summary: this study is evaluating the effect of two pre-test education methods on participants interested in genetic testing for hereditary cancer risk.

this prospective, randomized controlled trial will evaluate the effect of two pre-test education methods on the level of participation in genetic testing for hereditary cancer risk. a prospective study examines outcomes before the development of a disease. * the research study procedures include screening for eligibility, randomization and a series of questionnaires. * participants will be randomized, or assigned by chance, to one of two methods of pre-genetic test education and after completing either pre-test education participants will be offered the opportunity to have genetic testing performed two methods of pre-genetic test education: * video education * in-person counseling * genetic testing will be performed by blood draw. * it is expected that 500 people will participate in this study * participants will be in the research study for up to 5 yrs after enrollment

Eligibility criteria:
inclusion criteria: * potentially eligible participants will be identified via medical record screening and/or in accordance with their clinical visit. a hipaa waiver of authorization will be obtained by the enrolling institution as needed to have access to the subject's medical record information for screening of eligibility. * a member of the study team will approach the potentially eligible participant in clinic and discuss the trial. potentially eligible participants may choose to discuss participation further with their physician at their appointment * age ≥ 18 years * breast, ovarian, pancreatic, or metastatic prostate cancer * no prior cancer genetic testing * ability to understand and the willingness to sign an informed consent document exclusion criteria: * pregnant * prisoners * inability to understand english as a spoken language in a healthcare context * known hematologic malignancy (e.g. cll)

Keywords: breast cancer ovarian cancer pancreatic cancer metastatic prostate cancer genetic counseling genetic testing
steroids helping albuterol responders exclusively

Conditions: Bronchiolitis

Summary: the purpose of the study is to determine whether corticosteroids are beneficial to children with bronchiolitis whose breathing gets better after being given a breathing treatment with albuterol.


Eligibility criteria:
inclusion criteria: * diagnosis of bronchiolitis * respiratory distress assessment index score of 4 or more exclusion criteria: * prior prescription of bronchodilators or inhaled corticosteroids * birth at \<36 weeks gestation * chronic cardiac disease * chronic pulmonary disease (including asthma) * immunodeficiency * non-topical steroid use in the prior week * parents that don't understand english * baseline systolic blood pressure \>118 mmhg * home oxygen use * evidence of systemic fungal or varicella infection * bronchodilator use in the prior week * allergy to albuterol or corticosteroids

Keywords: bronchiolitis steroids corticosteroids albuterol child infant pediatric
assessment of the breast cosmesis using deep neural networks: an exploratory study (abcd)

Conditions: Breast Cancer

Summary: surgery and radiotherapy in breast cancer patients can cause treatment changes and may affect the final breast appearance. in this study, we are trying to evaluate the post treatment breast photographs of the patients and subject these to artificial intelligence based program so as to classify into appropriate categories based upon changes from baseline. this automated solution will help in decreasing the time required to achieve this task by physicians in the clinic.

a new algorithm was introduced which is based on deep neural network (dnn) which receives an image as input and returns the coordinates of the breast key points as output. these key points are then given to a shortest-path algorithm that models images as graphs to refine breast key point localization. the algorithm learns, directly from the image, to compute features and to use those features in the analysis of the aesthetic result. this comprises of two main modules: regression and refinement of heatmaps, and regression of key points. to perform the heatmap regression, the u-net model is used. the goal of the first module is to generate an intermediate representation consisting on a fuzzy localization for the key points that are to be detected. the second module receives and refines this fuzzy localization, and through complex calculations, outputting the x and y coordinates of the keypoints, and the data generated from which can be used for disease / image classification.

Eligibility criteria:
inclusion criteria: * confirmed diagnosis of primary breast cancer (invasive or in situ) * patient undergone breast conservation / whole breast reconstruction * patient received breast rt * already provided written informed consent on earlier projects * patient provided photographs of both breasts * non-metastatic disease or oligometastatic * age \> 18 years * reconsent given exclusion criteria: * mastectomy without whole breast reconstruction * bilateral breast cancer * partial breast irradiation * male patient * limited life expectancy due to co-morbidity * patients undergoing brachy boost

Keywords: cosmesis, photographic assessment, neural network
the effect of virtual reality training on mental health literacy and stigma

Conditions: Mental Health Disorder; Literacy; Stigma, Social

Summary: purpose: this study will be conducted to examine the effect of virtual reality training on nurses' mental health literacy and stigma level towards mental illnesses. design: the study is a randomized controlled experimental research. method: the population of the research consists of 110 nurses working in a public hospital. power analysis was performed with g\* power software to determine the number of nurses constituting the research sample. the sample size was determined as 25 people in each group. considering that there may be data loss in the study, it is planned to include 30 people in the intervention group and 30 people in the control group. nurses who volunteer to participate in the study and fill out the pre-test will be randomly assigned to the groups using the statistical analysis software program to ensure random distribution to the intervention and control groups. personal information form, mental health literacy scale (mhls) and opening minds stigma scale for healthcare providers (oms-hc) will be used in study data collection. hypotheses: h1: the mental health literacy level of nurses who receive training with virtual reality is higher than nurses who receive classical training. h2: the level of stigmatization towards mental illnesses of nurses trained with virtual reality is lower than nurses who received classical training.


Eligibility criteria:
inclusion criteria: * being 18 years or older * becoming a nurse * being actively working in a public hospital in istanbul * volunteering to participate in the study * not having worked in a psychiatric ward before exclusion criteria: being under 18 years of age * not being a nurse * not actively working in the hospital where the study will be conducted * not volunteering to participate in the study * having worked in a psychiatric ward before

Keywords: mental health disorder mental health literacy stigma virtual reality
evaluating panitumumab (abx-egf) monotherapy in patients with metastatic colorectal cancer following treatment with fluoropyrimidine, irinotecan, and oxaliplatin chemotherapy

Conditions: Colorectal Cancer; Metastatic Cancer

Summary: the purpose of this study is to determine that panitumumab will have clinically meaningful anti-tumor activity in patients with metastatic colorectal cancer who have developed progressive disease or relapsed while on or after prior fluoropyrimidine, irinotecan and oxaliplatin chemotherapy.

panitumumab was administered once every 2 weeks until participants developed progressive disease, were unable to tolerate panitumumab, or discontinued treatment for other reasons (eg, administrative decision). participants then attended a safety follow-up visit 4 weeks from the last panitumumab infusion. participants were subsequently contacted every 3 months from the last panitumumab infusion through month 24 to assess disease status and survival.

Eligibility criteria:
inclusion criteria: * pathologic diagnosis of colorectal adenocarcinoma (diagnostic tissue obtained by tissue biopsy) * metastatic colorectal carcinoma * eastern cooperative oncology group (ecog) performance status of 0, 1 or 2 * documented evidence of disease progression during, or following treatment, with fluoropyrimidine, irinotecan and oxaliplatin chemotherapy for metastatic colorectal cancer * radiographic documentation of disease progression during or within 6 months following the most recent chemotherapy regimen is required * bidimensionally measurable disease * tumor expressing epidermal growth factor receptor (egfr) by immunohistochemistry * at least 2 but no more than 3 prior chemotherapy regimens for metastatic colorectal cancer * adequate hematologic, renal and hepatic function exclusion criteria: * symptomatic brain metastases requiring treatment * patient with a history of interstitial pneumonitis or pulmonary fibrosis or evidence of interstitial pneumonitis or pulmonary fibrosis * use of systemic chemotherapy or radiotherapy within 30 days before enrollment * prior epidermal growth factor receptor targeting agents * prior anti-tumor therapies including prior experimental agents or approved anti-tumor small molecules and biologics of short (less than 1 week) serum half-life within 30 days before enrollment, or prior experimental or approved proteins with longer serum half-life (e.g., avastintm) within 6 weeks before enrollment

Keywords: egfr clinical trial panitumumab abx-egf immunex metastatic cancer vectibix abgenix amgen
effect of robot gait training with brain stimulation on gait function in stroke patients

Conditions: Stroke

Summary: the purpose of this study was to investigate the effects of robot gait training with the noninvasive brain stimulation in stroke patients.


Eligibility criteria:
inclusion criteria: * age: more than 18 years * more than 6 months post stroke * functional ambulation classification (fac) (1\~4) exclusion criteria: * serious cardiac conditions (hospitalization for myocardial infarction or heart surgery within 3 months, history of congestive heart failure, documented serious and unstable cardiac arrhythmias, hypertrophic cardiomyopathy, severe aortic stenosis, angina or dyspnea at rest or during activities of daily living) * difficult to understand experimental tasks because of extremely severe cognitive impairment * history of disorders involving central nervous system * history of psychiatric disease * implanted objects that would contraindicate tdcs
hla demographics study in adults with type 1 diabetes

Conditions: Diabetes Mellitus, Type I

Summary: this is a study to evaluate the hla-drb1\*04:01 genotype in adults that have been diagnosed with type 1 diabetes

this is a non-interventional study to evaluate the distribution of human leukocyte antigen (hla)-drb1\*04:01 genotype in participants that are recently (within 2 months of the study visit) diagnosed with t1d, with a single blood draw for the analysis of hla genotype within the study participants. the study duration will be 24 hours and will include a single study visit for the collection of demographic data and a single blood draw, and a follow-up telephone call 24 hours after the study visit.

Eligibility criteria:
inclusion criteria: 1. male and female participants aged ≥ 18 to ≤ 45 years, with type 1 dm meeting american diabetes association criteria at diagnosis: 1. fasting glucose ≥ 126 mg/dl (7.0 mmol/l), or 2. 2-hour oral glucose tolerance test plasma glucose ≥ 200 mg/dl (11.0 mmol/l), or 3. hemoglobin a1c ≥ 6.5%, or 4. random plasma glucose ≥ 200 mg/dl (11.1 mmol/l) (with documented classic hyperglycemia symptoms or hyperglycemic crisis). 2. date of t1d diagnosis within 2 months of the study visit. 3. able and willing to provide written, informed consent as approved by the institutional review board (irb). participants must be able to consent directly; no other person or guardian may consent for them in this study. exclusion criteria: 1. participant is an employee of, or an immediate family member of an employee, of the sponsor, study site, or of a contractor/vendor who is involved in direct study conduct for this protocol. 2. participant is unwilling or unable to comply with the study visit assessments.
evaluating innovative technologies and approaches to addressing cervical cancer in gaza and maputo cidade provinces in mozambique

Conditions: Cervical Cancer

Summary: the goal of this operational research study is to develop, implement and test integrated ccs\&pt and voluntary fp service delivery models to evaluate whether integrated service delivery can optimize uptake and health impact of both services. the study objectives and learning questions are listed below, along with key outcomes that will be measured.

objectives: the study objectives are outlined below: 1. to quantify the health impact of ccs\&pt on the uptake of voluntary fp services. 2. to quantify the health impact of voluntary fp on the uptake of ccs\&pt services. 3. to determine which promotional strategies are most effective to increase uptake of ccs\&pt services. 4. to identify cost to deliver high quality ccs\&pt services integrated into existing voluntary fp programs. 5. to determine client and provider acceptability of integrated ccs\&pt and voluntary fp services using new screen and treat technologies.

Eligibility criteria:
inclusion criteria: * women 30 - 49 years or all women living with hiv * not currently pregnant * patients with a cervix (women who have undergone a total hysterectomy with removal of the cervix are not eligible) * living in maputo or gaza * willing and able to provide informed consent for services. exclusion criteria: * not meeting the inclusion criteria * physical or mental impairment that inhibits participation in the study * pregnant women
levetiracetam for benign rolandic epilepsy

Conditions: Epilepsy

Summary: this study is designed to test if the language problems commonly seen in children with benign rolandic epilepsy would improve by switching anticonvulsants to levetiracetam.

this is a 6 month study in which children on another anticonvulsant would have eeg, language testing, and a clinic visit at baseline. they would then be rapidly transitioned off of their current anticonvulsant and onto levetiracetam (keppra). repeat eeg and language testing would be done after 6 months to evaluate for improvement.

Eligibility criteria:
inclusion criteria: * ages 6-12 * benign rolandic epilepsy * language difficulties as reported by parents or teachers * on another anticonvulsant other than levetiracetam exclusion criteria: * prior use of levetiracetam * on 2 or more anticonvulsants * language problems prior to epilepsy * another seizure disorder * status epilepticus within the past 6 months * significant psychiatric disease * progressive neurologic disease

Keywords: epilepsy benign rolandic levetiracetam
disease perception and oral health impact profile (ohip) before and after non-surgical periodontal treatment

Conditions: Periodontitis

Summary: the presence of periodontal diseases in patients has been associated to a worsened quality of life overall. many different indices have been proposed over time in order to evaluate patient's centred outcomes. in particular, the most thorough questionnaire proposed so far is the oral health impact profile 49 (ohip-49), which is composed of 49 questions. despite its validity being unquestionable, ohip-49 was found to be too time-consuming for the clinical scenario and, therefore, its shortened 14-question version has been proposed. a more in-depth knowledge of how these parameters change before and after periodontal treatment could enable clinicians to tailor the treatment plan according to the patients' needs.


Eligibility criteria:
inclusion criteria: * patients being at least 18 years old * patients with a diagnosis of periodontitis exclusion criteria: * diagnosis gingivitis * diagnosis of periodontal health * inability or unwillingness to give informed consent

Keywords: oral health impact profile 14 ohip 14 non surgical periodontal treatment brief-illness perception questionnaire
waitlist-control trial of smartphone cbt for major depressive disorder (mdd)

Conditions: Major Depressive Disorder

Summary: the investigators are testing the efficacy of smartphone-delivered cognitive behavioral therapy (cbt) treatment for major depressive disorder (mdd). the investigators hypothesize that participants receiving app-cbt will have greater improvement in sigh-d scores than those in the waitlist condition at treatment endpoint (week 8).

the primary aims of this study are to test the efficacy of a smartphone-based cbt treatment for adults with mdd recruited nationally. eligible subjects (n=112) will be randomly assigned to 8 weeks of smartphone-delivered cbt for mdd either immediately, or after a 8-week long waiting period (50-50 chance). the investigators hypothesize that smartphone-delivered cbt for mdd will be feasible and acceptable to individuals with mdd, and that it will lead to greater reductions in mdd symptom severity compared to the passage of time (waitlist control).

Eligibility criteria:
inclusion criteria: * at least 18 years of age * current diagnosis of primary dsm-5 mdd, based on mini * currently living in the united states exclusion criteria: * psychotropic medication changes within 2 months prior to enrollment (participants taking psychotropic medication must have been on a stable dose for at least 2 months prior to enrollment and not change medication during study period) * past participation in ≥ 4 sessions of cbt for depression * current severe substance use disorder * lifetime bipolar disorder or psychosis * acute, active suicidal ideation as indicated by clinical judgment and/or a score ≥ 2 on the suicidal ideation subscale of the c-ssrs * concurrent psychological treatment * does not own a supported mobile smartphone with a data plan * lack of technology literacy that would interfere with ability to engage with smartphone treatment
does mixing alcoholic drinks make hangover worse?

Conditions: Alcohol-Related Disorders

Summary: does mixing alcohol make hangover worse?

hangover is the most commonly occurring morbidity associated with heavy drinking. our aim was to test the hypothesis that mixing alcoholic drinks as compared to drinking one type of alcohol only (beer, wine or spirits) associate with a higher alcohol intake and worse hangover.

Eligibility criteria:
inclusion criteria: * written and oral consent * minimum 18 years old * participating in danish health research retreat in turkey 2016 * will consume alcoholic beverages exclusion criteria: * underage * will not consume alcoholic beverages

Keywords: alcohol, hangover