Kornimate/medical-research-clean huggingface dataset:
oral structural and functional problems in children with autism

Conditions: Autism Spectrum Disorder; Chewing Problem; Drooling

Summary: this study aims to examine oral structural and functional problems in children with autism.

in this descriptive study, children with autism will be screened for oral structural and functional problems. in this context, observational evaluation will be made. the presence of tongue thrust reflex, chewing performance and salivation control in children will be examined.within the scope of the research, demographic data, parameters related to the oral motor development stage (time to transition to solid food and solid food, time to first teething) will be recorded according to parental report. oral structural evaluation, including open mouth, high palate, oral hygiene and malocclusion, will be made observationally and recorded as present/absent. within the scope of oral functional evaluation, tongue thrust reflex, chewing function and salivation control (dooling) will be evaluated. the questions the investigators will test for this purpors; q1:what oral structural and functional problems are seen in children with autism? q2:what is the frequency of oral structural and functional problems seen in children with autism?

Eligibility criteria:
inclusion criteria: * diagnosed with autism, * not having any additional diagnosis other than autism, * age between 5-15 yers exclusion criteria: * not being able to receive the commands required to obtain working data.

Keywords: autism chewing drooling
quality of life model for older patients with aml

Conditions: AML, Adult; Acute Myeloid Leukemia

Summary: the purpose of this study is to describe the differences in quality of life (qol) among newly diagnosed patients diagnosed with acute myeloid leukemia (aml) to help design a patient decision-making qol model for aligning patients' choice of treatment with what matters the most to them.


Eligibility criteria:
inclusion criteria: * 60 years of age or older * newly diagnosed with pathology-confirmed diagnosis of acute myeloid leukemia * within 7 days of starting a new treatment * must be able to read and speak english at the 8th grade level exclusion criteria: * under 60 years of age * other malignancy, dementia, traumatic brain injury or individuals with central nervous system involvement of their leukemia
comparison of efficacy and safety of two different types of botulinum toxin type a in moderate to severe cervical dystonia

Conditions: Spasmodic Torticollis

Summary: the purpose of this study is to compare two types of botulinum toxin type a to treat the involuntary muscle contractions in the neck


Eligibility criteria:
inclusion criteria: * diagnosed with cervical dystonia/spasmodic torticollis for at least 18 months * successfully treated previously with botulinum toxin type a exclusion criteria: * breast feeding, pregnant or could become pregnant * surgery or spinal cord stimulation for cervical dystonia * previous injections of phenol, alcohol for cervical dystonia
bioequivalence study of clindamycin gel 1% in treatment of acne vulgaris

Conditions: Acne Vulgaris

Summary: this is a randomized, double-blind, multiple-site, placebo-controlled, parallel-group study, designed to compare the efficacy and safety of generic clindamycin 1% gel (akorn), and the marketed product clindamycin 1% gel (greenstone llc) in the treatment of acne vulgaris.


Eligibility criteria:
iinclusion criteria: * male or non-pregnant, non-lactating female, ≥12 and ≤40 years of age with a clinical diagnosis of acne vulgaris. * have facial acne with: ≥20 facial inflammatory lesions (papules and pustules) and ≥25 non-inflammatory lesions (open and closed comedones), and ≤2 nodulocystic lesions (nodules and cysts) and have an iga score of 2, 3 or 4. exclusion criteria: * subject has more than 2 facial nodular lesions; any nodules present will be documented but not included in the inflammatory lesion count for analysis. * subject has active cystic acne. * subject has acne conglobata. * subjects with excessive facial hair such as beards, sideburns, moustaches, etc. that would interfere with the diagnosis or assessment of acne.
primary vaccination study with gsk biologicals' pneumococcal vaccine in healthy infants in vietnam

Conditions: Infections, Streptococcal; Streptococcus Pneumoniae Vaccines

Summary: the purpose of the study is to evaluate the safety and reactogenicity of synflorix™ (gsk 1024850a) given as a 3-dose primary immunization course when co-administered with infanrix hexa™ vaccine at 2, 3 and 4 months of age in infants in vietnam.


Eligibility criteria:
inclusion criteria: * male or female subjects between, and including 6-12 weeks of age at the time of the first vaccination. * subjects for whom the investigator believes that their parents/guardians can and will comply with the requirements of the protocol. * written and signed or thumb-printed informed consent obtained from the parent(s)/lar of the child. where parent(s)/guardian(s) are illiterate, the consent form will be countersigned by a witness. * free of obvious health problems as established by medical history and clinical examination before entering into the study. exclusion criteria: * use of any investigational or non-registered product other than the study vaccine(s) within 30 days preceding the first dose of study vaccine, or planned use during the study period. * concurrently participating in another clinical study, at any time during the study period, in which the subject has been or will be exposed to an investigational or a non-investigational product. * acute disease and/or fever at the time of enrolment. * history of any reaction or hypersensitivity likely to be exacerbated by any component of the vaccine(s). * history of chronic condition(s) requiring treatment such as cancer or autoimmune disease. * hypersensitivity to latex. * previous vaccination against diphtheria, tetanus, pertussis, hemophilus influenzae type b and/or streptococcus pneumoniae. locally recommended epi vaccines to be given at birth are allowed, but should be administered at least one month before the first dose of the study vaccine is administered. other locally recommended vaccines are allowed, even if concomitantly administered with the study vaccines, but should be documented in the ecrf.

Keywords: pneumococcal vaccine
3-midline-ports cholecystectomy

Conditions: Postoperative Pain

Summary: the 3-midline-ports technique is a safety approach and associates lower postoperative pain, when compared with the standard "french" technique.

the patients will be randomized into 2 groups: those patients undergoing laparoscopic cholecystectomy following the "french" technique (group 1) and those ones undergoing the 3-midline-ports approach (group 2).

Eligibility criteria:
inclusion criteria: * patients undergoing elective cholecystectomy for symptomatic gallstones. exclusion criteria: * diagnosis of acute cholecystitis

Keywords: laparoscopic cholecystectomy postoperative pain
a comparative effectiveness study evaluating the effects of thermogenic supplements on body composition

Conditions: Weight Loss

Summary: the purpose of this study is to determine whether subjects taking a supplement designed to increase metabolic rate will have a positive effect on body composition (fat mass, muscle mass, and bone density.)

in a previous randomized double-blinded placebo-controlled pilot study, subjects taking the nutritional supplements contained in these two weight loss plans had a short-term statistically significant increase in their resting metabolic rates as compared to taking a placebo. no increases were found in blood pressure, resting heart rate, or self-reported discomfort when taking the supplement. the current study was designed to extend the findings of the pilot study over a 60-day study period using a randomized double-blinded placebo-controlled protocol with the same weight loss interventions.

Eligibility criteria:
inclusion criteria: * must ensure with medical provider that there are no medical conditions that would preclude participation * must be able to swallow capsules * must be age 21 or above exclusion criteria: * pregnant or breast feeding

Keywords: weight loss body composition fat free mass bone mineral density adipose tissue dual-energy x-ray absorptiometry body fat eating and appetite control basal metabolic rate
prospective registry of the current status of care for patients with coronary artery disease

Conditions: Coronary Artery Disease

Summary: the study will estimate the current status of care for participants with coronary artery disease


Eligibility criteria:
inclusion criteria: * hospitalized patients with discharge diagnosis as coronary artery disease (including atherosclerosis or non-athrosclerosis) exclusion criteria: * none
spyglass amea registry

Conditions: Biliary Stricture; Biliary Obstruction Due to Common Bile Duct Stone; Periampullary Tumor; Hemobilia

Summary: the purpose of this study is to document indications for cholangioscopy and clinical utility of the spyglass direct visualization system (dvs) throughout the amea (asia, middle-east, africa) region when used per standard of practice.


Eligibility criteria:
inclusion criteria: * age 18 or older. * willing and able to provide written informed consent to participate in the study. * willing and able to comply with the study procedures. * indicated for ercp and cholangioscopy or indicated for ercp with suspected need for cholangioscopy. exclusion criteria: * endoscopic techniques are contraindicated. * ercp is contraindicated * a medical condition that warrants the use of the device outside of the indication for use. * requirement for anticoagulation that cannot be safely stopped at least 7 days prior to the procedure.
neurobiological effects of oxytocin in schizophrenia

Conditions: Schizophrenia

Summary: 22 male patients with schizophrenia and 22 male healthy volunteers will be included in the study. subjects who meet the inclusion and exclusion criteria for the study will be recruited. after completion of clinical assessments and neuropsychological assessments, all subjects will undergo two multi-modal imaging sessions. in one scan they will receive intranasal oxytocin and in another scan will receive intranasal saline as control. the order of administration of the medication will be counterbalanced and subjects will be blind to the medication administered. using the simultaneous pet-mri scanner, pet and fmri data will be collected simultaneously. blood will be collected for analysis of oxytocin receptor gene polymorphism and its potential effect on brain activity.


Eligibility criteria:
schizophrenia group inclusion criteria: 1. diagnosis of schizophrenia or schizoaffective disorder 2. males between 18 and 45 years 3. capacity to provide informed consent exclusion criteria: 1. current comorbid axis i diagnosis and no alcohol/substance abuse/dependence in the last 12 months (except nicotine) 2. contraindication to oxytocin like hypersensitivity, vascular disease, chronic nephritis, epilepsy, asthma 3. contraindication to mri like implants/claustrophobia 4. past history of head injury resulting in loss of consciousness or neurosurgery 5. concomitant severe medical conditions 6. on treatment with benzodiazepine medications for at least 8 weeks 7. contraindication to positron emission tomography healthy volunteers inclusion criteria: 1. males between 18 and 45 years 2. capacity to provide informed consent exclusion criteria: 1. lifetime diagnosis of psychiatric illness including substance dependence 2. contraindication to oxytocin like hypersensitivity, vascular disease, chronic nephritis, epilepsy, asthma 3. contraindication to mri like implants/claustrophobia 4. past history of head injury resulting in loss of consciousness or neurosurgery 5. concomitant severe medical conditions 6. on treatment with benzodiazepine medications for at least 8 weeks 7. contraindication to positron emission tomography 8. family history of schizophrenia, schizoaffective or schizophreniform disorder in family member
trial comparing the safety of two different intravenous iron formulations

Conditions: Iron Deficiency Anemia; Perioperative Blood Conservation

Summary: the purpose of this trial is to compare the safety profile using equal doses of intravenous iron dextran versus iron sucrose. the researchers hypothesize that significantly more patients receiving intravenous iron dextran (using the current intermediate molecular weight product) will have severe adverse outcomes than patients receiving iron sucrose in the adult non-hemodialysis outpatient population. secondly, since these severe reactions may require additional nursing time and physician interventions that may negate any cost advantage of iron dextran, the researchers hypothesize that iron sucrose will be more cost-effective than iron dextran.


Eligibility criteria:
inclusion criteria: * age 18 to 100 * to be receiving intravenous iron exclusion criteria: * age \< 18 * hemodialysis * previous exposure to intravenous iron * unable to provide written consent

Keywords: intravenous iron safety perioperative iron deficiency non hemodialysis population perioperative blood conservation
identification and verification of neutrophil extracellular trap net related markers in acute-on-chronic liver failure

Conditions: Acute-On-Chronic Liver Failure

Summary: acute-on-chronic liver failure (aclf) refers to the acute deterioration of liver function in patients with chronic liver disease. neutrophils are a major component of the innate immune system, and previous studies have revealed enhanced production of neutrophil extracellular traps (nets) in aclf. however, there is still a lack of systematic research on the correlation between nets and the prognosis of aclf. we screened nets related biomarkers through bioinformatics analysis, which play an important role in the diagnosis of aclf. this study will explore whether these nets related biomarkers also play an important role in the prognosis of aclf and further investigate their role in the pathogenesis of aclf.


Eligibility criteria:
inclusion criteria: 1. patients who meet the diagnostic criteria of chinese group on the study of severe hepatitis b (cossh) for acute-on-chronic liver failure exclusion criteria: 1. age greater than 75 years old 2. liver cancer 3. previous liver transplantation 4. other serious extrahepatic organ diseases 5. uncontrolled bacterial infections.

Keywords: neutrophil extracellular traps
hematology and clinical picture in pediatric covid-19 infection

Conditions: Covid19

Summary: this study is to discuss the different clinical presentations, hematological and laboratory abnormalities in pediatric covid-19 infection.

this retrospective observational study will be conducted at benha university hospital, benha, egypt; after approval by the local ethical committee of faculty of medicine, benha university, egypt. we will include in this retrospective study all pediatric patients who were admitted with confirmed covid-19 infection with age range from birth to 18 years during the period from april 2020 till july 2020. the diagnosis of covid-19 infection is based on positive sars-cov-2 rna detection in throat swab specimens by pcr. all data including demography information, contact history, previous history, clinical symptoms, clinical examination on admission, and hematology and laboratory information will be obtained from inpatient medical records.

Eligibility criteria:
inclusion criteria: -inpatient confirmed covid-19 infection by pcr exclusion criteria: * patients with records missing hematology and/or laboratory data, * patients transfered to other medical facilities with unknown outcomes, * patients with age older than 18 years from the study.

Keywords: covid19 hematology pediatric
enhancing recruitment, linkage to care and treatment for hiv-infected msm in the united states

Conditions: HIV

Summary: the purpose of this study is to develop and assess the efficacy of an integrated strategy that includes feasible and scalable interventions to identify, recruit, link to care, retain in care, attain, and maintain viral suppression among hiv-infected men who have sex with men (msm) in the united states (us).

this study will use deep-chain respondent driven sampling (dc-rds) and direct recruitment (dr) to identify and recruit hiv-infected msm who are not virally suppressed. a subset of these men will be enrolled into one of two study arms. the intervention arm will provide a case manager (cm) intervention package designed to enhance linkage to care, antiretroviral treatment (art) initiation, treatment adherence and retention in care. the control arm will provide the standard of care (soc) for linkage to care, initiation of art, treatment adherence and retention in care. the primary outcome of the study is viral suppression 12 months after enrollment. phylogenetic methods will be used to evaluate the relationship between viruses in study participants. mathematical modeling will be performed using demographic, behavioral, and clinical data generated from this study and other sources to estimate the population-level impact of the cm intervention on hiv incidence and to estimate the level of identification, linkage, art coverage and viral suppression that would be required to achieve a substantial reduction in hiv incidence among msm in the us settings where the study is conducted.

Eligibility criteria:
inclusion criteria: individuals who meet all of the following criteria are eligible for study screening: * biological male (at birth) * self-report of history of anal intercourse with another man * 16 years or older individuals who are eligible for screening and who meet all of the following criteria are eligible for enrollment into the cm intervention and soc control arms: * hiv-infected, as defined in the hptn 078 study-specific procedures (ssp) manual * not virally suppressed (defined as hiv vl ≥ 1000 copies/ml) * can receive hiv care at one of the participating clinics (as chosen by each site) * no current plan to relocate in the 24 months following enrollment exclusion criteria: individuals who meet any of the following criteria will be excluded from study screening: * unable or unwilling to provide consent/assent for study participation. * active or previous participation in an hiv vaccine trial. * any condition that, in the opinion of the investigator of record (ior), would make participation in the study unsafe, complicate interpretation of study outcome data, or otherwise interfere with achieving the study objectives. individuals who are eligible for screening, but who meet the following criteria are excluded from enrollment into the cm intervention and soc control arms: • current participation in a linkage or art adherence study

Keywords: msm art ccm daids hptn aca paf pep rds
efficacy and safety of an2690 topical solution to treat onychomycosis of the toenail

Conditions: Onychomycosis of Toenails

Summary: the purpose of this study is to determine whether an2690 topical solution is a safe and effective treatment for onychomycosis of the toenail.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of distal subungual onychomycosis affecting at least one great toenail * koh positive at screening * willingness not to use any other products including nail polish applied to the toenails during the study * women of childbearing potential who are currently sexually active must agree to use contraception for the entire study period exclusion criteria: * concurrent or recent use of certain topical or systemic medications without a sufficient washout period * history of any significant chronic fungal disease other than onychomycosis * significant confounding conditions as assessed by study doctor * participated in any other trial of an investigational drug or device within 30 days or participation in a research study concurrent with this study * pregnancy or lactation

Keywords: onychomycosis nail fungus toenail fungus fungal nail hyperkeratosis nail infection nail treatment toenail infection toenail treatment foot dermatoses fungal culture onycholysis podiatrist podiatry subungual tinea unguium antifungal anti-fungal dermatologist dermatology dermatophyte distal subungual onychomycosis yellow nail thick nail brittle nail crumbling nail discolored nail weak nail
effect of pectoral electrostimulation on reduction of mammary ptosis

Conditions: Satisfaction

Summary: a prospective randomized clinical trial of patients undergoing bariatric surgery. patients were randomly assigned into 3 groups: those patients undergoing percutaneous electrostimulation (pens) of the pectoral muscle combined with specific training (group 1), those patients doing the specific training alone (group 2) and those patients without any specific treatment (group 3). the assigned treatment began 15 days after surgery and was maintained during 12 weeks.

a prospective randomized clinical trial of patients undergoing laparoscopic sleeve gastrectomy (lsg) or laparoscopic roux-en-y gastric bypass (rygb) during 2014 was performed. patients were randomly assigned using a random-number table into 3 groups: those patients undergoing percutaneous electrostimulation (pens) of the pectoral muscle combined with specific training (group 1), those patients doing the specific training alone (group 2) and those patients without any specific treatment (group 3). the assigned treatment began 15 days after surgery and was maintained during 12 weeks.

Eligibility criteria:
inclusion criteria: * patients with body mass index (bmi) \>40 kg/m2 or bmi \> 35 kg/m2 with the presence of comorbidities associated to obesity, undergoing a bariatric procedure. exclusion criteria: * all kind of previous breast surgery.
endothelial cell loss after phacoemulsification intra and supracapsular

Conditions: Cataracts

Summary: cataract is the clouding of the lens of the eye, which initially prevents clear vision and eventually progresses to blindness if left untreated. cataract remains the leading cause of blindness and an important cause of visual impairment across the globe. cataract surgery by ultrasonic phacoemulsification is the most common surgery practiced in france (600 000/year) two sub-categories of phacoemulsification coexist : endocapsulars techniques represented by divide-and-conquer and phaco-chop ; and supracapsular techniques mainly represented by subluxation (similar to tilt-and-tumble) the corneal endothelium plays an important role in maintaining the dehydrated state and the transparency of the cornea. some degree of endothelial cell loss invariably occurs in all types of cataract surgery but the amount of endothelial cell loss may varies with the type of surgical technique the aim of the study is to evaluate the density of the central corneal endothelial cells before and after cataract surgery comparing two phacoemulsification techniques (divide-and-conquer vs subluxation)


Eligibility criteria:
inclusion criteria: * male or female aged ≥ 18 years * patients undergoing cataract surgery * visual acuity monoyer scale \<6/10e (\< +0.2 logmar) * nuclear, cortical and posterior subcapsular cataract with normal density to severe in the locsiii classification exclusion criteria: * insulin-dependent diabetes and /or diabetic retinopathy * corneal disease: keratitis, dystrophy, corneal degeneration * any disease of intraocular pressure * any disease of the anterior segment * low preoperative endothelial cell density \< 1500 c/mm² * combined surgery (cataract + corneal transplant, cataract + glaucoma surgery, cataract +vitrectomy ...) * risk factors for surgical per-operative complication * pregnancy, lactation * ward of court * patient not covered by the social security scheme

Keywords: cataract surgery