Kornimate/medical-research-clean huggingface dataset:
a first in human study using 89zr-crgdy ultrasmall silica particle tracers for malignant brain tumors

Conditions: Brain Cancer; Pituitary Adenoma

Summary: the purpose of this study is to test if pet scans using 89zr-dfo-crgdy-peg-cy5-c' dot particles, can be used to take pictures of brain tumors. the investigators want to understand how the particles are distributed and removed from the body, which may help others be treated in the future. this will be the first time that 89zr-dfo-crgdy-peg-cy5-c' dot particles are being used in people. the amount of particles given in this study is very small compared to the amount that was used in mice animal studies.


Eligibility criteria:
inclusion criteria: * 18 years of age or older * histologically confirmed diagnosis of malignant primary brain tumor clinical and radiographic findings consistent with a pituitary adenoma, or known metastatic cancer with brain lesion presumed to be metastatic. * normal baseline cardiac function based upon pre-operative evaluation at the physcian's discretion * all patients of childbearing age must use an acceptable form of birth control * women who are pre-menopausal must have a negative serum pregnancy test exclusion criteria: * known pregnancy or breast-feeding medical illness unrelated to the tumor which in the opinion of the attending physician and principal investigator will preclude administration of the tracer °this includes patients with uncontrolled infection, chronic renal insufficiency, myocardial infarction within the past 6 months, unstable angina, cardiac arrhythmias other than chronic atrial fibrillation and chronic active or persistent hepatitis, or new york heart association classification iii or iv heart disease * more than one metastatic cancer active in the last 5 years * active metastatic cancer in addition to malignant primary brain tumor * weight greater than the 400-lb weight limit of the pet scanner * unmanageable claustrophobia * inability to lie in the scanner for 30 minutes

Keywords: 89zr-crgdy ultrasmall silica particle tracers pet scan 17-599
surgical outcomes of vaginal prolapse repair with elevate

Conditions: Vaginal Prolapse

Summary: the purpose of this study is to evaluate outcomes in patients having vaginal prolapse repair with the elevate prolapse repair kit and compare these outcomes to patients who had a repair with prolift. .

the investigators hypothesize that the less invasive elevate mesh results in a shorter operative time, lower blood loss, complications, postoperative pain and earlier discharge from the hospital.

Eligibility criteria:
inclusion criteria: * women who have had a vaginal repair with elevate prolapse repair kit exclusion criteria: * n/a
efficacy and safety of two treatment regimens of topical mob015 in adults with distal subungual onychomycosis

Conditions: Onychomycosis

Summary: onychomycosis is a fungal infection that affects fingernails and/or toenails. the purpose of this trial is to investigate if mob015 is effective and safe for treatment of patients with fungal infection of the toenails.


Eligibility criteria:
inclusion criteria: 1. male or female 2. 18 - 70 years 3. dso of at least one of the great toe(s) affecting 25 % to 75 % of the target nail (verified by blinded assessor before randomization) 4. positive culture for dermatophytes (i.e. trichophyton species; t. rubrum or t. mentagrophytes) 5. signed written informed consent exclusion criteria: 1. proximal subungual onychomycosis 2. dso of both great toenails where involvement has extended into the proximal portion of the target nail (unaffected proximal nail is less than 2 mm) 3. "spike" of onychomycosis extending to eponychium of the target nail 4. presence of dermatophytoma (defined as demarcated and localised thick masses of fungal hyphae and necrotic keratin between the nail plate and nail bed) on the target nail 5. other conditions than dso known to cause abnormal nail appearance 6. topical antifungal treatment of the nails within 1 month before screening 7. systemic use of antifungal treatment within 3 months before screening 8. signs of severe peripheral circulatory insufficiency 9. immunosuppression 10. participation in another clinical trial with an investigational drug or device during the previous 4 weeks before screening 11. known allergy to any of the tested treatment products 12. a pregnancy test indicating pregnancy in a woman of childbearing potential at screening (visit 1) 13. pre-menopausal (last menstruation ≤ 1 year prior to screening) sexually active women who : * are pregnant or nursing * are not surgically sterile * are of child bearing potential and not practising an acceptable method of birth control, or does not plan to continue practising an acceptable method of birth control throughout the trial (acceptable methods include intrauterine

Keywords: distal subungual onychomycosis
design and validation of a mobile health application for home-based musculoskeletal therapy in ankle sprain

Conditions: Ankle Sprains

Summary: "ankle sprain is a common musculoskeletal injury that can pointedly influence the quality of life of an indivual. old rehabilitation approaches often require recurrent clinic visits, which can be time-consuming, costly, and unreachable to many. this study aims to design and validate a mobile health application for home-based musculoskeletal therapy in ankle sprain.

the study will employ a randomized controlled trial design, involving patients with ankle sprains, healthcare professionals, and healthy volunteers. the mobile health application will be designed to provide personalized exercises, education, and monitoring to improve rehabilitation outcomes. the study will evaluate the effects of the mobile health application (m health) in reducing pain, improving functional ability, and ornamental quality of life. the study will also assess the usability and acceptability of the application among patients and healthcare professionals. outcome measurement tools will contain the foot and ankle ability measure (faam), numeric pain rating scale (nprs) and system usability scale (sus) the study will contribute to the development of an innovative, home-based rehabilitation solution for individuals with ankle sprains, improving accessibility and adherence to rehabilitation programs.

Eligibility criteria:
inclusion criteria: * adults, 18-65 years, both gender(male and female) will be included. * include participants clinically diagnosed with a lateral ankle sprain confirmed by a healthcare professional, with a clear timeframe such as within the last 4-6 weeks. * grade i and ii sprains (mild to moderate) will be included using nprs tool range from 0 to 6. * participants must own and be able to use a smartphone or tablet that is compatible with the mobile health application. * specify that participants must be able to read and understand the application interface language. * ensure participants can safely perform the exercises prescribed in the app without additional risk of injury exclusion criteria: * concurrent fractures of the leg or foot. * previous surgery in the affected ankle or surgery resulting from the current ankle sprain. * serious systemic illnesses (e.g. rheumatoid arthritis, or fibromyalgia). * neurological impairments or other conditions that may affect rehabilitation outcomes
deep learning optical coherence tomography (oct) and oct angiography (octa) in nvc

Conditions: Macular Degeneration Choroidal Neovascularization

Summary: to evaluate the activity of neovascular macula degeneretion as assessed by sd-octand oct-a using a split-person study design and deep-learning quantification.

exudative neovascular macular degeneration is the primarily an age-related retinal condition the optical coherence tomography angiography represents a novel and noninvasive diagnostic technique that allows a detailed and quantitative analysis of retinal and choriocapillary vascular features in order to choose the best therapy . the study evaluates the changes in structural optical coherence tomography and optical coherence tomography angiography features in neovascular macular degeration patients undergoing anti-vegf treatments using artificial intelligence.

Eligibility criteria:
inclusion criteria: age older than 50 years * diagnosis of neovascular macular degeneration * absence of previous retinal surgery and congenital eye diseases. * absence of errors of refraction * absence of lens opacities * absence of low-quality oct and octa images exclusion criteria:• age younger than 50 years * previous retinal surgery and congenital eye diseases * errors of refraction * lens opacities * low-quality oct and octa images
a study to evaluate the efficacy of tacrolimus in rheumatoid arthritis patients shown unsuccessful response to methotrexate

Conditions: Rheumatoid Arthritis

Summary: this study is to evaluate efficacy of 6 months treatment of tacrolimus in active rheumatoid arthritis patients who showed unsuccessful response against methotrexate.


Eligibility criteria:
inclusion criteria: * patients with more than 6 months history of rheumatoid arthritis according to acr criteria * patients who have been treated unsuccessfully to more than single dmards including methotrexate at the discretion of investigator * esr ≥ 30 mm/h or crp ≥ 1.0 mg/dl (esr: erythrocyte sedimentation rate, crp: c-reactive protein) * patients are required to have at least 3 of 66 joints assessed as swollen * patients are required to have at least 6 of 68 joints assessed as painful with pressure exclusion criteria: * pregnant or breast-feeding patients. patients who plan to bear children or breast-feed during the study and within 6 month after completion of study * previous experience of tacrolimus (ointment excluded) * renal impairment or serum creatinine \> 1.4 mg/dl * liver function failure as follows: viral hepatitis, non-viral hepatitis, cirrhosis, sgot/sgpt \> 2x upper limit normal * patients with history of pancreatitis, glucose intolerance or complication or who indicates any of the following criteria:blood glucose level \>110mg/dl before the meal and \>200mg/dl after the meal hba1c \> 6.4% * cardiac disease(ischemic heart disease, treatment-requiring arrhythmia, heart failure)or complications * other investigational drug within last 30 days * patients who have been treated with infliximab, adalimumab, or leflunomide within 8 weeks of start of the study

Keywords: tacrolimus prograf calcinurin inhibitor rheumatoid arthritis(ra)
psychological outcome of covid-19 lockdown on psychiatric hospital staff and close relatives

Conditions: Anxiety State; COVID-19; Isolation, Social; Health Personnel Attitude

Summary: the purpose of the investigators is to study the psychological impact of the covid-19 lockdown on the members of the ville evrard hospital staff and their close relatives, and to identify potential lockdown conditions that could increase anxiety, anger and depressive symptoms in this population.


Eligibility criteria:
inclusion criteria: * for hospital staff: adult members of the ville evrard hospital staff (trainees or employees) willing to participate to at least one survey during the covid lockdown. * for close relatives: adult relatives of the ville evrard hospital staff members, living or not with them. exclusion criteria: * none

Keywords: anxiety depression anger quarantine health care workers
evaluation of a pre-surgical virtual reality simulation for cancer surgery patients

Conditions: Anxiety State

Summary: this study will pilot test and explore the feasibility of a virtual reality simulation of the operating room environment to reduce anxiety/distress in cancer surgery patients. study objectives are to evaluate recruitment and data collection procedures, outcome measures, participant feedback on the virtual reality operating room intervention, and the inclusion of a treatment as usual group, and effects of the intervention on symptoms of anxiety/distress. results of this study will inform the design of an upcoming larger-scale rct to assess the efficacy of this intervention


Eligibility criteria:
inclusion criteria: * over the age of 18 * can speak and read english * has a cancer diagnosis * scheduled/being scheduled to undergo cancer surgery under general anesthesia at the health sciences centre (winnipeg, mb) exclusion criteria: * those who do not meet any inclusion criteria * those who are not competent to provide informed consent (e.g., due to cognitive impairment) * those who are unable to participate in a virtual reality intervention (e.g., due to visual/auditory impairment)

Keywords: preoperative anxiety cancer virtual reality feasibility pilot study
new mexico honey wound treatment research study

Conditions: Community-acquired Methicillin-resistant Staphylococcus Aureus Infection

Summary: in a time of emerging bacteria that are resistant to antibiotics, honey offers an alternative that has potential to reduce the heavy reliance on pharmaceutical antibiotics. we will be evaluating the effectiveness of a locally produced new mexico honey against the standard of care bactrim antibiotic on community acquired mrsa.

locally grown new mexico honey will be utilized on abscess wounds of the trunk and extremities vs routine (bactrim) antibiotic care to determine if nm honey is effective treatment for community acquired mrsa 6 cm abscesses.

Eligibility criteria:
inclusion criteria: * patients 16 years of age or older * abscess less than or equal to 6 cm in diameter on the extremity or trunk requiring incision and drainage * patient willing to try honey prepared dressing * patient able to return to office each day for 7 days for evaluation exclusion criteria: * under the age of 16 * abscess of face, scalp or genitals * diagnosed as a diabetic * allergic to bee pollen, honey or sulfa antibiotics * diagnosed with peripheral vascular disease * patient acknowledgement of current drug or alcohol abuse

Keywords: community acquired mrsa new mexico honey
clinical study about the role of cox-2 inhibitor in liver cirrhosis with biliary atresia

Conditions: Biliary Atresia, Kasai Portoenterostomy Status

Summary: in this clinical study, meloxicam will be used to the patients who are older than 2 years and underwent kasai portoenterostomy to treat their biliary atresia before. before and after the medication, their liver stiffness scores will be checked using hepatic fibroscan. liver stiffness scores will be compared before and after the medication of meloxicam, and the roll of the cox-2 inhibitor (meloxicam) in the patients with biliary atresia in releasing their hepatic fibrosis. also, the side effect of the drug will be checked. the intervention drug, meloxicam is safe medicine which is used to treat pain or inflammation caused by osteoarthritis or rheumatoid arthritis in adults and children who are at least 2 years old. it may also be used for purposes not listed in the medication guide. it will be taken once a daily with a dose of 0.125 mg/kg/day (high-dose group) or 0.06 mg/kg/day (low-dose group). after 6 months of medication, the maintenance will be decided by the comparison of liver stiffness score before and after the intervention.


Eligibility criteria:
inclusion criteria: 1. patients who had undergone a kasai portoenterostomy for ba, and who were postoperatively managed in our outpatient clinic 2. patients who made informed consent for clinical study of cox-2 inhibitor 3. patients who were followed up with liver fibroscan study 4. patients who were over 2 years old and less than or equal to 17 years exclusion criteria: 1. patients who were impossible to join the clinical study because of their underlying diseases (renal disease, liver disease, diabetes mellitus, gi disease, including bleeding, perforation, or ulceration, etc.) other than biliary atresia, ii) h. pylori infection, iii) asthma, iv) nasal polyp, v) hypertension, vi) hematologic disease, vii) coagulopathy, viii) cardiac disease, ix) vascular disease 2. patients who did not get the drug (cox-2 inhibitor) 3. patients who did not check liver fibroscan 4. patients who were impossible to join the clinical study because of their complication after kasai portoenterostomy 5. patients who did not make informed consent for clinical study of cox-2 inhibitor 6. patients who cannot take drug because of their allergy, skin disease or asthma attack to drug (cox-2 inhibitor) 7. patients who were decided to withdraw because of their severe drug adverse events
effect of progressive neck motor control exercises on temporomandibular joint dysfunction

Conditions: Temporomandibular Joint Dysfunction Syndrome

Summary: the primary aim of this study was to investigate the effects of progressive neck motor control exercises on craniocervical pain, posture, function and kinesiophobia in different types of temporomandibular dysfunction. the secondary aim of the study was to examine the differences between the effects of progressive neck motor control exercises on different types of temporomandibular dysfunction.

in this randomised controlled study, the effects of progressive neck motor control exercise therapy on craniocervical pain, posture, function and kinesiophobia in individuals with different types of temporomandibular dysfunction (myofascial, disc displacement with reduction, disc displacement without reduction) and their differences with the control group will be compared. participants diagnosed by a dentist according to three different types of temporomandibular dysfunction will be included in the study. participants will be divided into groups by block randomisation method. a total of 6 groups will be included in the study, including participants with three different types of temporomandibular dysfunction who voluntarily agree to participate in the study and meet the inclusion criteria, and the control group of each group. the study groups will receive the same treatment and patient education for 6 weeks, while the control groups will receive only patient education.

Eligibility criteria:
inclusion criteria: * 18 to 55 years old, * temporomandibular joint-related complaints for at least 3 months, * temporomandibular dysfunction is diagnosed as a result of clinical and radiological evaluation by the dentist, * neck pain of 3 or more according to the numeric pain scale exclusion criteria: * cognitive problems, * the one with the splint, * those who have used painkillers or muscle relaxants for temporomandibular dysfunction complaints in the last 1 week, * with any systematic joint or muscle disease (e.g. fibromyalgia, rheumatoid arthritis), * those with serious systemic diseases, * any neurological disorder (e.g. trigeminal neuralgia), * pregnancy or breastfeeding, * treated for temporomandibular joint or orofacial muscle pain in the last 3 months, * has undergone an operation/trauma to the cervical region and/or temporomandibular joint, * positive vertebrobasilar artery test

Keywords: temporomandibular joint dysfunction syndrome pain neck motor control exercise posture kinesiophobia function
executive function disorders and anxio-depressive symptomatology in children and adolescents with mitochondrial pathologies

Conditions: Mitochondrial Diseases

Summary: the major steps forward of the neurosciences in recent years have linked psychiatric diseases, neuropsychological symptoms and brain dysfunctions. the cerebral functioning requiring a big quantity of energy, mitochondria, essential organelles in the cellular energy processes, are at present considered as a way of research for big interest in neurology and in psychiatry. thus, an increasing number of studies describe potential links between mitochondrial dysfunction and psychiatric symptomatology. the clinical symptomatology of children with mitochondrial cytopathy is varied. well described neurologically and somatically, it is significantly less in its psychiatric aspects. however, psychiatric symptoms are frequently associated and this symptom has already been described in adult patients. the symptoms mainly include depressive and anxiety disorders, or even tables suggestive of psychotic disorders, which would precede the diagnosis of mitochondrial disease of 13 years on average. neuropsychological disorders refer to disorders of the higher functions following a cerebral anomaly (language, praxis, motricity, gnosis, visual spatial processing, memory, attention, intelligence, executive functions ...). tests validated in french and adapted to children and adolescents can identify neuropsychological disorders in these populations.


Eligibility criteria:
inclusion criteria: * child with mitochondrial cytopathy (defined by the presence of a mutation known to cause mitochondrial cytopathy or mitochondrial respiratory chain abnormality) * aged 6 to 17 years * beneficiary of a social security regime * parents sign consent exclusion criteria: * child refusal to participate in the study * complete inability to complete questionnaires (e.g. non-communicating child) * child already included in intervention research modifying care
repository corticotropin injection to treat rheumatoid arthritis patients who have failed three biologic therapies.

Conditions: Rheumatoid Arthritis

Summary: it is hypothesized that repository corticotropin injection in combination with other biologic agents will be able to provide relief of both rheumatoid arthritis and acute exacerbations of rheumatoid arthritis for patients with disease that had inadequately responded to biologics previously.

although there are many types of treatment for rheumatoid arthritis (ra) currently available, some patients have disease that is refractory to treatment and cannot achieve remission. the objective of this study is to assess the efficacy and safety of subcutaneous injections of repository corticotropin as an adjunct therapy in patients with active ra who have had an inadequate response to at least two biologic agents as well as a third agent they are currently receiving.

Eligibility criteria:
inclusion criteria: * rheumatoid arthritis of at least 2 years duration * on at least third biologic with a different mechanism of action for at least 12 weeks * active disease as defined by at least 6 tender and 6 swollen joints * erythrocyte sedimentation rate (esr) at least 28 mm/hr or c-reactive protein (crp) at least 1.2 times the upper limit of normal * stable dose of disease modifying anti-rheumatic drug (dmard) and prednisone for at least 4 weeks exclusion criteria: * prior treatment with acthar gel * history of intolerance or allergy to glucocorticoids * unstable diabetes * active infection

Keywords: rheumatoid arthritis joint pain repository corticotropin injection
weight reduction and cognitive health: pilot study testing a prolonged testing prolonged fasting among obese, stressed mid-life adults

Conditions: Midlife Obese Adults With Cognitive Decline

Summary: using a randomized controlled trial (rct) design, we will test feasibility and outcomes following an remotely delivered, nationwide 8-week prolonged nightly fasting (pnf) intervention compared to an health education control (hec) in 50 obese, stressed mid-life adults to explore outcomes related to cognitive function, metabolism and associated lifestyle behaviors.


Eligibility criteria:
inclusion criteria: * 40-59 years old * experiencing memory loss * bmi 30-45.9 * pss-4 score ≥5 * access to smartphone, zoom, and wifi * lives in united states exclusion criteria: * diabetes * pregnant, * neurological disorder * eating disorder within last 20 years * in current weight loss program * previously had bariatric surgery * works a night shit * health condition not conducive to nightly fasting