Kornimate/medical-research-clean huggingface dataset:
venous thromboembolism and bleeding in hospitalized medical patients with cancer

Conditions: Hemorrhage; Vein Thrombosis

Summary: patients with cancer hospitalized for an acute medical illness have an increased risk of venous thromboembolic events. although international guidelines suggest the use of thromboprophylaxis in these patients, the recommendations are based on studies which included a percentage of patients with cancer without primarily focusing on this high risk group. since patients with cancer present an increased risk of bleeding complications it is critical to evaluate the safety of thromboprophylaxis in the cancer group. recent studies suggest a limited use of thromboprophylaxis in these patients. the aim of this study is to evaluate the use, efficacy and safety of thromboprophylaxis in medical cancer patients hospitalized for an acute medical disease. design: observational, prospective study primary end-point: incidence of major and clinically relevant non major bleeding during hospitalization secondary endpoints: frequency of use, doses and contraindications for pharmacological thromboprophylaxis; venous thromboembolic events up to three months after discharge


Eligibility criteria:
inclusion criteria: * all patients with cancer hospitalized for an acute medical illness exclusion criteria: * current use of oral or parenteral anticoagulant treatment * no informed consent to participate
induction chemotherapy with nimotuzumab in locally advanced head and neck squamous cell carcinoma (hnscc)

Conditions: Head and Neck Cancer

Summary: the aim of the study is to evaluate the role of nimotuzumab in the neo-adjuvant setting in patients with locally advanced hnscc. the hypothesis is that the response would be increased with the combination of nimotuzumab and cisplatin and fluorouracil (pf) regimen.

induction chemotherapy followed by radiotherapy is the standard treatment for patients with unresectable hnscc. however, the role of induction chemotherapy remains uncertain for resectable disease. therefore, we plan to perform a phase ii study to evaluate it, focusing on radiographic and pathologic response after induction chemotherapy. moreover, a new egfr monoclonal antibody (nimotuzumab) is incorporated with pf regimen. the hypothesis is the addition of nimotuzumab would improve the response without remarkably increase the toxicity.

Eligibility criteria:
inclusion criteria: * age range 18-70 years old * ecog performance status 0-1 * histologically confirmed and potentially resectable locally advanced (t2-4, n0-3, m0) hnscc * adequate organ function exclusion criteria: * history of other malignancies except cured basal cell carcinoma of skin and carcinoma in-situ of uterine cervix * pregnant or lactating women * serious uncontrolled diseases and intercurrent infection * previous serious cardiac disease

Keywords: hnscc induction chemotherapy nimotuzumab
comparing the efficacy of two methods in the prevention of adhesion reformation after hysteroscopic adhesiolysis

Conditions: Intrauterine Adhesion

Summary: asherman's syndrome is characterized by the presence of intrauterine adhesions (iua) as well as symptoms such as amenorrhea, hypomenorrhea, pelvic pain, and infertility. the gold standard for the treatment of intrauterine adhesions is hysteroscopic intrauterine adhesions. the recurrence of intrauterine adhesions is a major challenge in clinical practice. it has been reported that dried biological aminion graft was used to prevent adhesion after the operation of intrauterine adhesions. estrogen is also used for postoperative prevention of intrauterine adhesions. intrauterine balloon can reduce the recurrence of adhesions after operation. does the combination of balloon with amniotic products or estrogen can improve clinical outcomes? therefore, this study was conducted.

allocation: randomized endpoint classification: efficacy study intervention model: parallel assignment masking: double (participant and outcomes assessor) primary purpose: prevention

Eligibility criteria:
inclusion criteria: * age 20-40 years； * previously diagnostic hysteroscopy confirmed adhesion score \>5， according to the american fertility society （afs）classification of iua； * complains of menstruation disorder and reproductive dysfunction； * informed consent. exclusion criteria: * premature menopause, * presence of other intrauterine lesions (e.g. polyps, myoma, septa), and * presence of severe intercurrent illness (e.g. systemic disease, coagulative disorders, severe kidney and liver diseases), * adhesions limited to the lower uterine cavity or the cervical canal.

Keywords: asherman syndrome hysteroscopy uterine stent estrogen amnion hysteroscopic adhesiolysis
culturally based family therapy for improving treatment outcome for people with schizophrenia

Conditions: Schizophrenia

Summary: this study will evaluate the effectiveness of a culturally based family therapy intervention in improving treatment outcome in people with schizophrenia.

schizophrenia is a disabling mental disorder that affects approximately 1% of the population worldwide. people with schizophrenia frequently experience hallucinations, delusions, disordered thinking, movement disorders, emotional numbness, social withdrawal, and cognitive deficits. these symptoms can hinder a person's ability to perform everyday functions, such as hold a job and maintain normal social relationships. when combined with medication, family-oriented therapy interventions have been beneficial for people with schizophrenia. there are few programs, however, that are tailored to the needs of minorities. with the rising number of minority populations in the u.s., it is important to develop psychotherapy interventions that are designed specifically for these groups. this study will evaluate the effectiveness of a culturally based family therapy intervention in improving treatment outcome in people with schizophrenia. participants in this 12-month, open label study will first attend a 2-hour screening visit, at which information will be gathered regarding coping styles, spirituality, and expressed emotion. participants will then be randomly assigned to receive either culturally based therapy or treatment as usual. although the culturally based therapy will be tailored to the needs and values of hispanics, people who are not hispanic will not be excluded. the culturally based therapy will entail 15 weekly therapy sessions, which will focus on family unity, psychoeducation, spirituality, communication skills, and problem-solving. the group receiving treatment as usual will attend 3 weekly psychoeducation sessions that will focus on informing participants about schizophrenia. outcomes for both groups will be assessed upon completion of treatment and at follow-up visits at months 6 and 12.

Eligibility criteria:
inclusion criteria: for participants with schizophrenia or schizoaffective disorder: * diagnosis of schizophrenia or schizoaffective disorder * currently taking medication * 18 or older for all participants: * two or more family members, including patient, are available for participation (therapy can be conducted if patient is not available, as long as two other family members are interested in participating) * family members must be at least 13 years old exclusion criteria: * n/a

Keywords: culture family therapy
bioequivalence study on pediatric appropriate formulation

Conditions: Hypercholesterolemia

Summary: to determine bioequivalence of a atorvastatin pediatric formulation comparing to the 10 mg commercial atorvastatin calcium tablet formulation.

determination of bioequivalence

Eligibility criteria:
inclusion criteria: * healthy male and/or female subjects * mass index (bmi) of approximately 18 to 30 kg/m2 exclusion criteria: * any condition possibly affecting drug absorption * a positive urine drug screening

Keywords: cardiovascular diseases
circulating tumor dna (ctdna)-guided late-line treatment in patients with late-stage breast cancer

Conditions: Metastatic Breast Cancer; Circulating Tumor DNA; Gene Abnormality

Summary: this is a retrospective, observational, multi-center clinical study of circulating tumor dna (ctdna) to guide late-line therapy in late-stage metastatic breast cancer patients.

this study aims to evaluate the feasibility of plasma ctdna mutation in guiding late-line treatment for late-stage metastatic breast cancer patients. meanwhile, this study tries to evaluate the curative effect of ctdna subtype-guided late-line therapy.

Eligibility criteria:
inclusion criteria: * recent progression of tnbc after multiple lines of chemotherapy or of hr+ or her2+ mbc after multiple lines of endocrine or targeted therapy; * no available recommendation for the next treatment regimen; * an eastern cooperative oncology group (ecog) performance status of 0 to 2; * an updated, available pathological hr/her2 status for metastasis; * according to recist 1.1 standard, there should be at least one measurable target lesion; * the expected survival time is \> 3 months; * those aged 18-70 years old; * liver and kidney function and blood routine test meet the following conditions: neutrophil \> 2.0g/l, hb \> 9g / l, plt \> 100g / l; alt and ast \< 2.5uln; tbil \< 1.5uln; cr \< 1.0uln * signing informed consent; * those willing to accept polygenic testing. exclusion criteria: * patients with multiple primary tumors; * those who are unable to obtain blood samples; * those with a history of immunodeficiency or organ transplantation; * those with abnormal cardiac function or previous history of myocardial infarction or serious arrhythmia; * the researchers think it is not suitable to participate in this experiment.
photobiomodulation and glass ionomer sealant as complementary treatment for hypersensitivity in molars with mih

Conditions: Hypomineralization Molar Incisor

Summary: introduction: photobiomodulation (pbm) shows promising results for the complementary treatment of dentin hypersensitivity; however, few studies have evaluated this treatment specifically for teeth affected by molar incisor hypomineralization (mih). the aim of this study was to assess the effects of photobiomodulation combined with glass ionomer sealant on hypersensitivity in molars with mih. methods: forty-nine children six to twelve years of age with a molar affected by mih (grade 3, 4a or 4b) of the mih-tni (treatment needs index) criteria were randomly allocated to two groups - group 1 (control group) (n = 25): toothpaste with fluoride concentration ≥ 1000 ppm (parts per million) twice per day, glass ionomer sealant and simulated pbm; group 2 (study group) (n = 24): toothpaste with fluoride concentration ≥ 1000 ppm twice per day, glass ionomer sealant and active pbm. data collection involved the record of mih, schiff cold air sensitivity scale (scass), visual analog scale (vas), the simplified oral hygiene index (ohi) and the colour, coverage, caries (ccc) sealant evaluation system. results: forty-six children completed the study and were evaluated one month after the onset of treatment. a significant reduction in the schiff cold air sensitivity scale (scass) was found only in the active pbm group. reductions in visual analog scale (vas) scores were observed in both groups, with a statistically significant difference between the groups at the 48-hour and 1-month assessments following pbm application. similarly, significant differences in the oral hygiene index (ohi) were found only in the active pbm group when comparing baseline values to those after 48 hours and one month. a significant difference between the groups was noted for sealant durability at one month, with better scores in the active pbm group. conclusion: the administration of photobiomodulation combined with glass ionomer cement improves hypersensitivity and oral hygiene in molars with mih. the improvement in oral hygiene increases the quantity of remaining sealant on teeth with mih.


Eligibility criteria:
inclusion criteria: * healthy individuals (asa i); * children aged 6 to 12 years with at least one permanent first molar affected by mih grades 3 and 4 (a and b) according to the mih treatment needs index (tni), and with hypersensitivity score 2 or higher on the visual analog scale (vas); * molars with fractures and without pulp involvement or active caries; * molars with eruption of the entire occlusal surface and at least one-third of the vestibular surface. exclusion criteria: * molars with hypersensitivity caused by carious lesions were excluded to avoid diagnostic confusion with pulpitis; * teeth that had undergone desensitizing treatments in the previous three months, except for daily use toothpaste; * those with fixed orthodontic appliances; patients who experienced discomfort during the hypersensitivity test, or those unable to tolerate the procedure were also excluded.
study of the effect of prehabilitation on markers of sarcopenia in patients undergoing pancreatoduodenectomy for malignant disease

Conditions: Pancreatic Ductal Adenocarcinoma

Summary: the aim of this study is to assess whether prehabilitation supervised by an appropriate multimodality team improves indices of sarcopenia in patients scheduled to undergo pancreatoduodenectomy.

cachexia is a hallmark feature of pancreatic cancer. patients with features of cachexia have worse clinical outcomes. this includes a reduction in quality of life, reduced tolerance of therapy and a poorer prognosis . specifically related to patients undergoing pancreatic surgery clinical evidence of cachexia is associated with higher perioperative complication rates. sarcopenia, defined as a decreased muscle mass independent of fat mass, is a feature of the cachexia associated with pancreatic cancer. patients with sarcopenia have progressive and generalised reduced muscle mass and function in patients undergoing surgery for pancreatic cancer sarcopenia has been associated with increased rates of complication and worse survival . treatment of sarcopenia is difficult but includes nutritional support and pancreatic enzyme replacement therapy (pert) aimed at reducing malabsorption. whether measures aimed at combating sarcopenia can improve clinical outcomes following pancreatic surgery is currently unknown. prehabilitation is a multimodal therapeutic regimen aimed at improving the overall physical condition of patients prior to surgery with the intention of reducing the incidence of perioperative complications. emerging evidence suggests that exercise prior to surgery for high risk patients scheduled to undergo major abdominal surgery improves aerobic capacity and can reduce the incidence of perioperative complications . the impact of prehabilitation undertaken prior to pancreatic surgery on perioperative complication rates has not yet been investigated. the aim of this study is to assess whether prehabilitation supervised by an appropriate multimodality team improves indices of sarcopenia in patients scheduled to undergo pancreatoduodenectomy.

Eligibility criteria:
inclusion criteria 1. patients treated by pancreatic resection 2. surgery for malignancy 3. patients aged over 16 4. ct scans available for assessment exclusion criteria 1. patients scheduled for fast-track pancreatic resection as part of the jaundice pathway 2. aged under 16 3. patients not undergoing pancreatic resection

Keywords: pancreas cancer sarcopenia cachexia prehabilitation pancreatoduodenectomy
preliminary study of fish oil and dementia

Conditions: Alzheimer's Disease; Mild Cognitive Impairment

Summary: this preliminary study is aimed to investigate whether it is feasible to conduct a study to use fish oil compared to the placebo(olive oil) in people with cognitive impairment. we will also explore whether fish oil has better efficacy in some clinical aspects in people with cognitive impairment during 24 weeks intervention. the major clinical outcome will be: 1. general clinical impression 2. cognitive function

despite some positive findings from observational and animal studies, the effects of n-3 pufa administration on cognitive impairment in humans have received little evaluation to date. although some clinical trials of fish oil have been reported, the results are inconsistent. given these inconsistent findings, we carried out a preliminary study to investigate the effect of fish oil monotherapy on cognitive function and general clinical condition in patients with cognitive impairment.

Eligibility criteria:
inclusion criteria: * fulfilled the diagnosis of ad according to the american psychiatric association, dsm-iv criteria, with mild or moderate severity( defined by an mini mental status examination (mmse) score between 10 and 26, and a clinical dementia rating (cdr) score of 1 or 2.) * or amnesic mci( defined as (1). subjective memory impairment by the patient and /or an informant, (2) objective memory impairment falling at least 1.5 standard deviations or more below age- and education-specific norms on the logical memory delayed-recall score from the wechsler memory scale iii (3) relatively normal performance in other cognitive domains, (4) no impairment in activities of daily living, and (5) failure to meet dsm-iv criteria for dementia.) exclusion criteria: * inadequate motor or sensory capacity to comply with testing * any ischemic lesion on brain ct reported by the radiologist or a modified hachinski ischemic scale score \>4 * a 17-item hamilton depression scale (hdrs)score \> 13 * abnormal levels of folic acid, vitamin b12, or thyroid function * severe comorbidity, including another neurodegenerative diseases, another chronic debilitating neurological illness (e.g. cerebral palsy), brain trauma, tumors, severe pulmonary, renal, liver disease, cardiac disease, or autoimmune disease, or conditions expected to cause death within one year. * participants with a diagnosis of alcoholism, schizophrenia, and bipolar disorder were excluded. * participants receiving cholinesterase agents during the screen or taking nsaid on a long-term basis

Keywords: polyunsaturated fatty acids alzheimer's disease mild cognitive impairment fish oil cognition
effect of switch to aripiprazole on health and smoking parameters in patients with schizophrenia: a pilot study

Conditions: Schizophrenia

Summary: patients with schizophrenia are much more likely to be engaged in smoking and other addictive behaviors, possibly related to biochemical abnormalities in the reward center of the brain. the primary purpose of the present study is to investigate whether switching patients with schizophrenia to a new atypical antipsychotic, aripiprazole, a drug with a novel mechanism of action, will have an impact on smoking behavior.

this is an 8 week open label trial being conducted in stable adult outpatients with schizophrenia who are smokers. the primary intervention is a switch in the subject's antipsychotic to aripiprazole, flexibly dosed between 15-30 mg/day. the outcome measures include a rating of smoking behavior using the fagerstrom test for nicotine dependence, and saliva cotinine obtained at baseline and endpoint. secondary measures include weight, serum glucose and lipids, rating of symptom severity using the panss, and both ratings and instrumental measures of motor functioning. we anticipate enrolling up to 25 subjects to obtain the needed 15 completers at the week 8 endpoint.

Eligibility criteria:
inclusion criteria: 1. schizophrenia, on stable antipsychotic dose for at least one month 2. ages 18-65 inclusive 3. overweight (body mass index of 25 kg/m2 or greater) 4. daily cigarette smoker (by self-report) exclusion criteria: 1. inability to provide informed consent 2. treatment refractory schizophrenia 3. current treatment with clozapine 4. current antipsychotic polypharmacy which may preclude monotherapy with aripiprazole 5. documented poor compliance with oral antipsychotic medication

Keywords: schizophrenia smoking metabolic health glucose lipids
peep recruitment-comparison between ultrasonographic assessment and lip assessment

Conditions: Acute Respiratory Distress Syndrome

Summary: the purpose of this study is to compare lung recruitment in acute lung injury (ali)/acute respiratory distress syndrome (ards) based on lower inflection point with transthoracic ultrasonographic assessment of lung recruitment.

sedated and sometimes temporary relaxed patients with ali/ards on mechanical ventilation in semirecumbent position are included. lower inflection point on pressure volume loop on ventilator draeger evita 4 with low continuous flow on volume controlled ventilation is measured with zero peep. transthoracic lung ultrasound with linear probe is proceed on both hemithoraces when mechanical ventilation based on measured peep is started. we compare if real lung recruitment seen by ultrasound is the same as predicted by lower inflection point. the procedure is a part of routine everyday respiratory monitoring in our unit.

Eligibility criteria:
inclusion criteria: * patients with diffuse ali/ards on mechanical ventilation with visible lower inflection point on dynamic p-v loops exclusion criteria: * preexisting parenchymal or pleural lung disease

Keywords: lung ultrasonography pressure-volume loops ards
effect of peri-operative supplemental oxygen in wound infection after appendectomy

Conditions: Perioperative Hyperoxygenation; Wound Infection

Summary: the study evaluates the role of supplemental hyper-oxygenation given perioperatively on wound site infection after appendectomy. half of the patients received ≥50% oxygen and half of them received no oxygen during the surgical procedure.

patient with the diagnosis of acute appendicitis of \>15 years of age group, with no comorbidities who presented to surgical emergency in dr. ram manohar lohia hospital were considered for the present study. 30 patients who fulfilled the inclusion criteria and who voluntarily consented for the study were randomly allocated to the two groups- group a (control group) and group b (study group). these patients were operated through mc-burney incision given in the right lower quadrant. both the groups were comparable in their demographic and preoperative profile. the study group was given ≥50% of oxygen intraoperatively and the control group was given no oxygen. in postoperative period, oxygen was given to group a at the rate of 4 litre/minute (l/min) and group b at the rate of 6 litre/minute (l/min). the assessment of the wound was done by using asepsis (additional treatment; serous discharge; erythema; purulent exudate; separation of deep tissues; isolation of bacteria; and stay) score. a score of more than 20 is considered to be infected. fever, raised total leucocyte count, positive pus culture, ultrasound evidence of fluid collections, removal of sutures and duration of hospital stay were also measured for the evaluation of economic implications due to ssi.

Eligibility criteria:
inclusion criteria: 1. clinical diagnosis or radiological diagnosis of acute appendicitis. 2. appendectomy through the mc burney incision. exclusion criteria: 1. patients with chronic obstructive pulmonary diseases. 2. immunodeficiency disease. 3. patients requiring midline incision. 4. patients requiring general anaesthesia after failure of spinal anaesthesia. 5. patients requiring higher oxygen in perioperative period.

Keywords: perioperativehyperoxygenation wound site infection appendicitis