community-associated highly-resistant enterobacterales

Conditions: Enterobacteriaceae Infections; Community-Acquired Infections; Healthcare Associated Infection; Carbapenem-Resistant Enterobacteriaceae Infection

Summary: this is a prospective multi-center study. bacterial isolates from hospitalized patients with ca-hre will be compared to those from hospitalized patients with healthcare-associated hre (ha-hre). in addition, community spread of cre will be determined.

patients who are discharged home from the hospital and meet criteria for possible ca-hre will be recruited. these index participants will be interviewed to determine the epidemiologic network, and will be mailed a monthly biowipe kit to screen for ongoing hre intestinal carriage. contacts of the index participant will also be approached and mailed a biowipe kit to screen for the presence of hre and/or carbapenemase gene(s) that were present in the index patient. if this initial sample is negative, the contact is not further interviewed or tested. if the initial screening is positive for the carbapenemase gene of interest, then the contact will be asked to answer the same questions as the index patient and will receive a monthly biowipe kit. for each positive contact, a second-generation network of contacts will be constructed, who in turn will be approached for screening. an additional subset of participants, those with cdc-defined hre isolated during hospitalization who are not discharged home will also be included. all hre isolates that are isolated from the patient as part of routine clinical care will be sub-cultured and shipped to the central research laboratory. a limited data set will be collected.

Eligibility criteria:
inclusion criteria: category 1: patients who live at home and meet the following criteria: * cdc-defined hre isolated during a previous hospitalization or outpatient visit * home origin * first positive hre culture within 48 hours of admission (in case of hospitalization) category 2: hospitalized patients with cdc-defined hre isolated during hospitalization who are not discharged home and who meet any of the following criteria: * admitted from other care facility (not home origin) * do not have first positive hre culture within 48 hours of admission category 3: patients with cdc-defined hre isolated during a previous hospitalization or outpatient visit who are eventually discharged home and who meet any of the following criteria: * admitted from other care facility (not home origin) * do not have first positive hre culture within 48 hours of admission (in case of hospitalization) category 4: participants who meet the following criteria: • community contact of a participant in category 1 and/or 3. exclusion criteria: in all categories, participants who meet the following criteria will be excluded: • age \<18 years in category 1, the following are exclusionary: * pre-existing renal failure * pre-existing liver disease * immunocompromised * history of malignancy * pregnancy in addition, in category 1, 3 and 4, who meet the following criteria will be excluded: • unable to provide informed consent

Keywords: infection bacterial infection cre enterobacterales