myocardial injury noncardiac surgery in geriatric patients

Conditions: Myocardial Injury After Noncardiac Surgery (MINS)

Summary: in inpatients aged 45 years and older, the approximate peri-operative mortality rate after non-cardiac surgery is around 1% to 2%. half of these deaths are attributed to cardiovascular complications of surgery. postoperative cardiac troponin elevation with ≥1 measurement of cardiac troponin ≥99% percentile above the upper limit of the reference value, which is an indicator of acute myocardial injury, is seen in the first 30 days after surgery and usually occurs within 72 hours. myocardial damage is thought to result from an ischemic mechanism. clinical symptoms may be masked by sedation or analgesia in the perioperative period, so evidence of an ischemic feature (e.g. ischemic symptoms, electrocardiographic changes) is not required. these criteria are defined as mins (myocardial injury non cardiac surgery) criteria. in this study, the investigators aimed to investigate the intensive care follow-up processes and outcomes of geriatric patients over 65 years of age in whom mins was detected during postoperative intensive care monitoring.

in this study study, 117 geriatric patients aged ≥65 years who were followed and treated in the intensive care unit in the postoperative period after general or regional anesthesia between january 2018 and august 2023 after obtaining ethics committee approval (fsm eah-kaek 2023/140) were retrospectively analyzed. age, gender, comorbidities, coronary artery disease, heart failure, atrial fibrillation, history of chronic renal failure, presence of emergency surgery, preoperative antiaggregant use, asa score, type of surgery, presence of laparoscopic or open surgery, anesthesia and duration of surgery, intra operatively; hypotension, tachycardia, bradycardia, presence of blood and blood products transfusion, duration if hypotension developed, first day of intensive care unit hospitalization; apache, saps, sofa scores, duration of mechanical ventilation, presence and duration of troponin elevation, the day of hospitalization, if cardiac examination was performed; ejection fraction, diastolic dysfunction, presence of revascularization treatment, hemoglobin, hematocrit levels on the day of troponin elevation, neutrophil/lymphocyte ratio, procalcitonin, crp levels, use of antiaggregants, mechanical thrombophylaxis, acidosis, presence of hypoxia, need for vasopressor therapy, type of discharge from intensive care unit and presence of mortality will be recorded

Eligibility criteria:
inclusion criteria: * patients aged 65 years or older * patients who underwent major, moderate, or minor surgery under general and/or regional anesthesia * patients who were followed and treated in the postoperative intensive care unit exclusion criteria: * patients younger than 65 years of age * patients with preoperative troponin levels above the normal reference range * patients with active myocardial ischemia symptoms (e.g., chest pain, pain radiating to the neck, jaw, shoulder, or arm) * patients with known pre-existing cardiac disease

Keywords: myocardial injury intensive care unit geriatric patients troponin elevation icu outcomes anesthesia