Kornimate/medical-research-clean huggingface dataset:
study of the ability of a flu vaccine to prevent flu infection

Conditions: Influenza

Summary: the purpose of this study is to evaluate how effective the vaccine is at preventing subjects developing flu symptoms after they are directly exposed to flu virus. the study will also evaluate how well the vaccine is tolerated at sites where administrations are given, any effects it may have on subjects' wellbeing and whether it can produce antibody responses in the body

influenza is a contagious disease of the upper airways and the lungs. it rapidly spreads around the world in seasonal epidemics, killing hundreds of thousands of people and having high economic consequences due to healthcare costs and lost productivity. each year governments recommend groups who are at risk of influenza or its complications to receive influenza vaccination. current vaccine supply is not sufficient to meet the demand if this recommendation were to be taken up by all. this study will evaluate powdermed's particle mediated epidermal delivery (pmed) dna vaccine for influenza as a potential alternative to existing vaccine technologies. this study will assess how effective two different pmed vaccine combinations are at preventing subjects developing influenza following exposure to flu virus 56 days after a single dose of vaccine.

Eligibility criteria:
inclusion criteria: healthy adult volunteers (women must be of non child-bearing potential) provided written informed consent exclusion criteria: no significant concomitant illness no allergy to gold no immunosuppression due to disease or treatment pre-existing protective level of antibody against the challenge virus strain

Keywords: dna vaccine influenza immunogenicity tolerability pmed efficacy challenge virus
adaptation of work in a hospital and assessment of feelings of quality of life at work, teleworking and face-to-face

Conditions: Work-Related Stress; Work-Related Condition

Summary: the adaptawork_2 study is a follow-up to the first qualitative study, to evaluate the feelings of hospital workers in all occupations about teleworking. this involves measuring the variation between three periods: before the covid-19 pandemic, during the first lockdown an after the pandemic. secondary objectives were: 1) to evaluate wich factors were associated to the feelings towards teleworking, 2) to assess musculo-squeletal disorders among teleworkers and the other participants, 3) to assess psycho-social risks among teleworkers and the oher participants, and 4) to evaluate teleworking costs

this is a quantitative study carried out at the clermont-ferrand university hospital and in the hospital centers of the homogenous territorial group (htg). the target population was made up of all hospital workers in these establishments who agreed to participate and complete the online questionnaire, regardless of their function or grade in the work establishment.

Eligibility criteria:
inclusion criteria: * all hospital workers in the university hospital centre of clermont-ferrand, and the hospitals belonging to the same htg who agreed to participate and complete the questionnaire, regardless of their function or grade in the work establishment exclusion criteria: n/a

Keywords: teleworking working at home
acupuncture for symptoms of nerve damage

Conditions: Peripheral Neuropathy; Chemotherapy-induced Peripheral Neuropathy

Summary: the purpose of this study is to compare the effects of real acupuncture with placebo acupuncture or usual care on symptoms of nerve damage from chemotherapy.


Eligibility criteria:
inclusion criteria: * english-speaking * age ≥ 18 years old * solid tumor survivors with no evidence of disease * moderate to severe cipn, defined by symptoms such as numbness, tingling, or pain ratings of 4 or greater on a 0-10 numeric rating scale (nrs) * have completed neurotoxic chemotherapy at least 3 months prior to enrollment * if taking anti-neuropathy medications, they are on a stable regimen (no change in 3 months) exclusion criteria: * patients with a pacemaker * prior acupuncture treatment within 5 years of enrollment

Keywords: acupuncture 17-298
dyslipidemia-related risk factors in dialysis

Conditions: Chronic Renal Disease; Cardiovascular Disease; Dyslipidemia

Summary: in this study, we studied lipoprotein abnormalities-related variables as risk factors for the development of cardiovascular disease in patients on renal replacement therapies.we studied 96 dialyzed patients, 62 males and 34 females, on mean age 62.1 years old and 24 healthy controls.we concluded that metabolic acidosis activating the inflammation and lipoprotein oxidation influences the dyslipidemia and cardiovascular morbidity of patients on renal replacement therapies.dialysis adequacy was positively associated to cardioprotective hdl.peritoneal dialysis holds a better acidosis level and lower oxidized lipids than hemodialysis modalities.

blood samples were obtained by venipuncture in the peritoneal dialyzed patients and control group in a twelve hours fasting state.in hemodialyzed patients blood was drawn just before the start of the mean weekly dialysis session also in a twelve hours fasting state from the vascular access. all samples were received once at baseline time ( in the start of the study ). peripheral systolic and diastolic blood pressures were calculated as an average of 10 measurements during a renal replacement treatment month in the starting time of the study. also, electrocardiographic examination, echocardiography and the calculation of ankle-brachial blood pressure index became once in the start of the study.

Eligibility criteria:
inclusion criteria: * permanent renal replacement therapy more than 6 months and * accurate dry body weight exclusion criteria: * acute illness, * significant infection, * malignancy, * kt/v for urea \<1.2.

Keywords: hemodialysis, dyslipidemia, cardiovascular disease
analgesic effect of morphine added to transverses abdominis plane block

Conditions: Pain, Postoperative; Postoperative Complications

Summary: postoperative pain is a condition that increases morbidity and mortality. therefore, multimodal analgesia techniques with fascial plan blocks are frequently used.tap block provides analgesia in the anterior abdominal wall by applying local anesthetic to the fascia between the internal oblique and transversus abdominis muscle. opioids can be added to local anesthetics to increase the quality and duration of analgesia. the investigators aim is comparasion of tap block with bupivacaine added morphine and tap block with bupivacaine plus intramuscular morphine effects on postoperative pain score, total opioid consumption and systemic effects in lower abdominal surgery

at the end of the operation, patients will be randomly divided into 2 groups as group i (intramuskuler) and group t (tap block). the blocks will be administered under general anesthesia in supine position by same anesthesiologist. group i (intramuskuler) will be applied 20 ml of %0.25 bupivacaine between the internal oblique and transversus abdominis muscle and 0.1 mg/kg (ideal body weight) morphine to be performed intramuscular. group t will be applied 20 ml of %0.25 bupivacaine and 0.1 mg/kg morphine (ideal body weight) between the internal oblique and transversus abdominis muscle. at the end of the operation, the patients with a modified aldreate score ≥9 will be sent from the postoperative anesthesia unit. all patients will be equipped with an iv morphine patient-controlled analgesia (pca) device. the solution will be prepared such that morphine is 0.5 mg / ml. pca 1mg bolus dose will be delivered with 10 min lock-out time. in the postoperative period, the patient was evaluated by another researcher who blind to the groups at the 1st and 6th, 12th and 24th hours. visual pain scores (vas) in rest and movement, hemodynamic values, morphine consumption, nausea-vomiting score, itching, ramsey sedation scale, length of hospital stay and postoperative complications will be recorded.

Eligibility criteria:
inclusion criteria: * asa i-ii * lower abdominal gynecological surgery exclusion criteria: * patients with a known allergy to the study drugs, * significant cardiac, respiratory, renal or hepatic diseases, * bleeding diathesis * those with psychiatric illnesses that would interfere with perception and assessment of pain were excluded from this study.

Keywords: postoperative pain transversus abdominis plane block morphine
a study of how safe abrocitinib (cibinqo) is in pregnant women and their offspring

Conditions: Atopic Dermatitis

Summary: the purpose of this observational study is to learn about the safety of abrocitinib (cibinqo) in pregnant women and the offspring. the study is seeking participants who: * are currently or recently pregnant * receive at least one dose of cibinqo at any time during pregnancy or prior to pregnancy or have a diagnosis of moderate-to-severe atopic dermatitis all participants in this study will receive treatment according to routine care, as this is an observational study. the exposed group will consist of pregnant women exposed to abrocitinib during pregnancy. the unexposed group will consistent of pregnant women with moderate-to-severe atopic dermatitis who are not exposed to abrocitinib during pregnancy. the study will compare the experiences of pregnant women receiving abrocitinib to pregnant women who do not. this will help us determine if abrocitinib is safe during pregnancy. participants will take part in this study until their infant is 12 months of age. during this time, the participant's care will be managed no differently than if she was not taking part in this study. data will be collected through a virtual research coordinating center at enrollment, the end of the second trimester, and pregnancy outcome (live birth or fetal loss). for live-born infants, data on the infants will be collected at 4 and 12 months of age. no additional visits beyond routine care will be required.


Eligibility criteria:
inclusion criteria: * women of any age who are currently or recently pregnant (recently pregnant defined as enrollment within 1 year of pregnancy outcome) * consent to participate in this study and evidence of a personally signed and dated informed consent document indicating that the patient (or a legally acceptable representative) has been informed of all pertinent aspects of the study * authorization for her healthcare provider(s) to provide data to the registry * must receive at least one dose of cibinqo at any time during pregnancy or prior to pregnancy (within 1 day prior to the date of conception) or have a diagnosis of moderate-to-severe atopic dermatitis at any time prior to pregnancy outcome. exclusion criteria: * participants will be excluded from the registry if they do not meet the inclusion criteria listed above.

Keywords: pregnancy dermatitis, atopic
diagnostic accuracy of shear-wave elastography for the preoperative risk stratification of follicular lesions of the thyroid

Conditions: Thyroid Nodule; Follicular Neoplasm

Summary: as many as 70-85% subjects diagnosed with a follicular lesion on biopsy and undergoing surgery will have benign lesions verified by histopathology after surgery. currently there is no method of pre-operatively diagnosing benign follicular lesions, as a result these subjects will have had surgery for diagnosis of a benign lesion. the aim of this study is to see whether shear-wave elastography, a new ultrasound technology can help pre-operatively diagnose benign follicular lesions. if successful, a lot of patients will not need surgery for the diagnosis of a benign lesion. the main goal of this study will be to evaluate the diagnostic accuracy of a new ultrasound technology, shear-wave elastography (swe), for the diagnosis of malignancy in follicular lesions. participants who have been diagnosed with a follicular lesion on thyroid biopsy and are scheduled for thyroid surgery will be eligible to participate. all participants will undergo a detailed ultrasound examination prior to their surgery. the results of the ultrasound will be compared with histopathology after surgery to test the diagnostic accuracy of swe.


Eligibility criteria:
inclusion criteria: * patients diagnosed with a follicular neoplasm on fine needle aspiration biopsy * patients \>18 years of age exclusion criteria * none

Keywords: thyroid follicular neoplasms bethesda system elastography doppler ultrasound thyroidectomy
hpv self-sampling to improve access to cervical cancer screening for persons with hiv and/or underserved individuals

Conditions: Cervical Cancer

Summary: the objective of this study is to evaluate self-collection of vaginal samples for hpv testing as an alternative cervical cancer screening strategy for persons with hiv and/or limited access to care. self-collection kits will be offered to persons who refuse a pap smear or are overdue (\>=6 months) for cervical cancer screening, with screening uptake recorded as a primary outcome. kits will be offered in-clinic to individuals who refuse a pap smear, and individuals overdue for screening will have the option to receive and return kits in the mail. the investigators will additionally administer a phone-based survey to evaluate knowledge about hpv and cervical cancer, barriers and facilitators to screening, and attitudes towards screening. data from medical records will be abstracted to describe the clinical characteristics of the sample and measure receipt of follow-up procedures. focus groups will be conducted with clinic administrators, staff, and hiv and women's health experts to evaluate clinic and provider barriers and facilitators to cervical cancer screening. the investigators hypothesize that hpv self-sampling will result in favorable patient-centered outcomes and could reduce disparities in access to screening.


Eligibility criteria:
inclusion criteria: * age \>=25 and \ =30 years (individuals with diagnosed hiv) * female sex at birth * proficient in english or spanish * refused a pap smear or are \>=6 months overdue for cervical cancer screening exclusion criteria: * current pregnancy * complete hysterectomy * history of cervical cancer * unable to provide informed consent

Keywords: screening self-collection self-sampling cervical cancer hpv hiv
phase iii trial of vinflunine plus best supportive care vs. best supportive care in patients with transitional cell carcinoma (tcc) of the urothelial tract

Conditions: Transitional Cell Carcinoma of the Urothelial Tract; Bladder Cancer; Bladder Neoplasms

Summary: the purpose of this clinical research study is to learn if patients who receive vinflunine plus best supportive care live longer than patients who receive best supportive care alone. this study will also investigate patient benefit, safety and whether or not vinflunine shrinks or slows the growth of the cancer.


Eligibility criteria:
inclusion criteria: * bladder cancer * progressed after 1st line platinum-chemotherapy * \>= 18 years old * adequate hematologic, hepatic \& renal function exclusion criteria: * cns disease * moderate neuropathy * more than 1 previous chemotherapy
an exploratory study of a wearable robotic hand orthosis

Conditions: Stroke

Summary: upper limb deficits usually remain in 75% of the stroke survivors despite completing full rehabilitation. this is due to lack of effectiveness of rehabilitation and the degree of support and resources available. in this study, the investigators plan to study the use of assistive technologies in chronic stroke survivors.

assistive technologies have shown promising results in immediate improvement in functional abilities. relab tenoexo is a fully wearable and portable robotic hand orthoses (rho) used for functional training. its design support end users with functional hand opening and closing and can be applied in therapy exercises or during functional activities. while prior research demonstrated its effectiveness for spinal cord injury, it hasn't been tailored for multi-ethnic stroke populations. this study aims to determine the feasibility and extent to which the relab tenoexo can complement therapy training in clinic and further be used as both a training and assistive device in the home environment. in addition, it also aims to investigate the amount of upper limb usage before, during and after the training period.

Eligibility criteria:
inclusion criteria: * patient with first ever clinical stroke (ischaemic or haemorrhagic) with hemiplegic motor deficit(s) due to stroke as diagnosed by ct or mri. * post stroke of at least 6 months with stable neurological status. * age 21 to 80 years of age. * hemiplegic pattern and shoulder abduction mrc motor power \> 2/5 and elbow extension \>2/5 * has a stable home abode and a carer/nok to assist with donning of device and supervise home based exercise * moca \> or equal to 22/30 * able to give and sign informed consent at research site. * able to speak english exclusion criteria: * non-stroke related causes of arm motor impairment. * has unstable or terminal medical conditions which may affect participation (e.g.: unresolved sepsis, postural hypotension, end stage renal failure, cancer, retroviral disease, on immunosuppressive therapy) or anticipated life expectancy of \<1 year due to malignancy or neurodegenerative disorder. * local factors which may be worsened by intensive arm therapy: spasticity of modified ashworth scale grades 3-4, skin wounds, shoulder pain pain scale \>5/10, active/non-united fractures or arthritis or fixed joint/tissue flexion contractures of shoulder, elbow, wrist or fingers incompatible with tenoexo interface. * patient with severe cognitive, perceptual (include hemi-neglect), and/or emotional-behavioural issues that preclude participation. * experiencing moderate to severe levels of pain (numerical vertical pain scale \> 5). * is pregnant or breast feeding. neither the tenoexo nor the imus have been tested to evaluate the usage with pregnant and/or breast feeding mothers. further, due to the length of the study, pregnancy may make it difficult to follow the study schedule. * have a pacemaker. magnets are used throughout the system.

Keywords: hand exoskeleton robot robotic hand orthosis
ethnopharmacological studies in oral medicine

Conditions: Oral Pain; Oral Ulcers; Oral Tumors

Summary: these are ethnomedicine studies of plants used by rural and indigenous peoples for pain and oral inflammation relief.

these are ethnomedicine studies of plants used by rural and indigenous peoples for pain relief in central and south america.

Eligibility criteria:
inclusion criteria: * patients who use plants to relieve oral pain, inflammations, ulcers, and tumors

Keywords: oral mucosal pain oral inflammations anisillo cordonsillo piperaceae oral ulcers oral tumors mucosal pain mucosal inflammations cordoncillo
intradialytic aerobic exercise in ckd patient

Conditions: Chronic Kidney Diseases

Summary: intradialytic aerobic exercise is not effective in increasing hemodialysis adequacy but is effective in improving physical performance in twice-weekly hemodialysis patients.

uremic myopathy occurs in 60-75% of chronic kidney disease (ckd) patients undergoing hemodialysis, which causes a decrease in muscle strength and physical performance. increasing dialysis adequacy is beneficial in reducing the impact of uremia on muscles. intradialytic aerobic exercise in thrice-weekly hemodialysis patients has improved dialysis adequacy and physical performance. this study aims to determine the effect of intradialytic aerobic exercise on improving dialysis adequacy and physical performance in twice-weekly hemodialysis patients.

Eligibility criteria:
inclusion criteria: * end stage renal disease patient stage 5 with glomerular filtration rate \<15ml/minute/1.73m2 aged 25-54 years undergoing hemodialysis two times per week for three months to five years * hemoglobin levels \> 8mg/dl * mini-mental state examination (mmse) score of ≥24 * hamilton depression rating scale (hdrs) score \<25 exclusion criteria: * received aerobic exercise in the last 3 months * history of hospitalization in the last 3 months * access for hemodialysis circulation via the femoral vein. * imt \<18,5 (underweight) dan ≥35 (obese class ii) * non-stable cardiovascular disease, uncontrolled glucose, acute infection disease

Keywords: chronic kidney disease intradialytic aerobic exercise physical performance
time restricted eating on cancer risk

Conditions: Pre-diabetes; Breast Cancer; Time Restricted Feeding

Summary: participants will be randomly assigned to either the time restricted feeding group with a daily eating period of 8 hours or the control group with a daily eating period of greater than or equal to 12 hours. there are 2 in-person study visits to have blood, urine and vital signs collected and 8 remote or phone visits with a psychologist or dietician to assist with the eating schedule. the study will take last 3 1/2 months.


Eligibility criteria:
inclusion criteria: * age ≥ 40 and ≤ 67; * postmenopausal women (no menstrual periods in the preceding 12 or more months) with pre-diabetes (a1c 5.7-6.4% and/or fasting glucose 100-125 mg/dl). a1c lab and/or fasting glucose criteria will need to be met within 12 months of signing consent form, can be obtained from prior lab result or study prescreening testing; * own a smart phone with internet connection and capable of receiving and sending text messages and taking photographs; exclusion criteria: * tobacco use (current or within last 2 years); * active malignancy or history of cancer; * history of known liver disease (by serology: aspartate aminotransferase or alanine aminotransferase ≥ 3 times above upper limit of normal determined by lab review, imaging or biopsy: determined by patient history); * history of kidney disease (patient history and/or estimated glomerular filtration rate less than 45 ml/min/1.73m²); * history of diabetes mellitus: * history of cardiovascular disease (mi, chf); * current prescription medication use for diabetes; * medication affecting glucose metabolism or appetite or immunosuppression; * dietary restrictions: currently following vegetarian or vegan dietary pattern; * currently following intermittent fasting or time restricted feeding pattern or use in the last 3 months; * night shift worker (work schedule does not involve any period of work from 10 pm to 5 am either on a regular or rotating basis); * history of weight loss \>5% in the last 3 months; * history of weight loss surgery. * bmi≥40 kg/m² exclusion; * after informed consent and run in period: insufficient documented food photography/annotated entries (does not log at least two entries a day for 10 of 14 days) during run in period will be excluded from randomization in to the intervention period.