Kornimate/medical-research-clean huggingface dataset:
gastric per oral endoscopic myotomy (g-poem) in refractory gastroparesis

Conditions: Gastroparesis Postoperative; Gastroparesis Due to Diabetes Mellitus; Idiopathic Gastric Stasis

Summary: refractory gastroparesis is a disease characterized by a delayed gastric emptying without a mechanical obstruction. actual treatments have a limited efficacy and gastric per-oral endoscopic myotomy (g-poem) is a new treatment that has demonstrated initial promising results in these patients. the investigators aims are to evaluate security and efficacy of this endoscopic treatment in participants with refractory gastroparesis.

gastroparesis is a chronic, condition characterized by a delayed gastric emptying without a mechanical obstruction. this disease is associated with high morbidity and mortality with a prevalence up to 4% of population. patients with this disease have a reduced quality of life. the principal etiologies include: post-surgical, diabetes, medications and idiopathic. symptoms include nausea, vomiting, early satiety, bloating and abdominal pain. diagnosis is based on the combination of symptoms and studies as gastroscopy that shows retained food in the stomach without a gastric outlet obstruction and confirmed with a gastric emptying scintigraphy. treatments have limited effect in these patients, including medications, botulinum toxin injection, surgical gastric electrical stimulation, laparoscopic pyloroplasty and stent placement. g-poem is a new technique based on per-oral endoscopic myotomy treatment in achalasia patients, which has been recently proposed for treatment of patients with refractory gastroparesis with good initial results. the investigators aim is to evaluate the safety and efficacy of this new technique in a group of mexican participants with this disease.

Eligibility criteria:
inclusion criteria: * patients with refractory gastroparesis based on delayed gastric emptying symptoms: nausea, retching, vomiting, abdominal pain, early satiety, post-prandial fullness, bloating. * refractoriness defines as the presence of symptoms with failure or recurrence after other type of treatment. * any etiology: diabetes, post-surgical, idiopathic exclusion criteria: * pregnancy * portal hypertension * gastric malignant condition * active prepyloric ulcer * mechanical pyloric stenosis

Keywords: g-poem safety efficacy
constraint induced movement therapy summer camp

Conditions: Cerebral Palsy; Cerebral Palsy, Diplegic, Infantile

Summary: constraint induced movement therapy (cimt) is an intervention for unilateral cerebral palsy (cp). it is currently part of standard of care for children with unilateral cp, but is typically done one-on-one and with the child wearing a cast 24 hours a day during the duration of treatment. the purpose of this study is to assess the effects of an intensive group-based cimt summer camp in which participants wear a removable cast on upper extremity function, occupational performance, and patient-specific goals. the investigators hypothesize that upper extremity skills and occupational performance will increase, and that patients will reach their individualized goals.


Eligibility criteria:
inclusion criteria: * scores of level i, ii or iii on the manual ability classification system * independent grasp * ability to ambulate independently or with an assistive device * sufficient cooperation and cognitive understanding to participate in a group. exclusion criteria: * lack of hand function * fixed contractures * active seizures * high tone * medical instability * non-english speaking parents.

Keywords: hemiparesis occupational therapy
standardization of surgery on the pancreatic cancer

Conditions: Pancreatic Cancer

Summary: this study was designed to test the hypothesis that more extensive nodal and soft-tissue clearance in patients with adenocarcinoma of the head of the pancreas would improve survival without an increase in morbidity and mortality.

in japan and in some western treatment centers, there has been a general belief that more extensive surgery may improve outcome for patients with localized, operable pancreatic adenocarcinoma. initial retrospective reports from centers in japan suggested that 5-year overall survival rates in patients treated with pancreaticoduodenectomy plus extended lymphadenectomy were higher than those in patients treated by pancreaticoduodenectomy with standard lymphadenectomy. subsequent prospective randomized trials performed in europe and the united states failed to confirm a survival benefit from extended lymphadenectomy. although they failed to confirm a survival benefit from extended lymphadenectomy, the studies had a few pitfalls. the need for well-designed randomised controlled study is the starting point of our study. this study was designed to test the hypothesis that more extensive nodal and soft-tissue clearance in patients with adenocarcinoma of the head of the pancreas would improve survival without an increase in morbidity and mortality.

Eligibility criteria:
inclusion criteria: * age : 20- 85 years old * no evidence of metastasis and to be possible to resect radically * no history of previous radiation therapy or chemotherapy * pathological diagnosis: adenocarcinoma of pancreas * patients who agree and sign the informed consent * more than 70 in karnofsky performance scale exclusion criteria: * past medical history of treatment for other malignant disease * recurred pancreatic cancer patients * patients with r1/r2 resection * patients who underwent neoadjuvant chemotherapy

Keywords: pancreatic cancer pancreaticoduodenectomy extended lymphadenectomy
comparative, multicenter study in subjects with rheumatoid arthritis, alvoflex

Conditions: Rheumatoid Arthritis

Summary: this is a study to compare the efficacy, safety and immunogenicity of avt05 versus eu-simponi® in combination with methotrexate (mtx) in subjects with moderate to severe rheumatoid arthritis (ra). the study will consist of up to 4-week screening period, a 48-week treatment period, and a 4-week safety follow-up period.


Eligibility criteria:
inclusion criteria: * subjects diagnosed with active ra according to acr/eular 2010 classification criteria * subjects diagnosed with moderately to severe active ra as defined by ≥ 6 swollen (out of 66) and ≥6 tender (out of 68) joint counts, crp \>1mg/l and with at least one of positive rheumatoid factor, positive anti-citrullinated peptide antibodies and/or evidence of 1 joint erosion of hands, wrist of dominant hand or feet at screening * subjects must have taken methotrexate for ≥12 weeks exclusion criteria: * prior treatment with biologics or janus kinase inhibitors that may be used as disease-modifying anti-rheumatic drugs * any past or concurrent medical conditions that could potentially increase the subject's risks or that would interfere with the study evaluation, procedures or study completion * major chronic inflammatory disease or connective tissue disease other than ra or any active autoimmune disease * presence of chronic obstructive pulmonary disease * presence of chronic heart failure nyha class iii or iv
a study to identify and characterise bacteria causing chronic cough among children in united kingdom

Conditions: Infections, Respiratory Tract

Summary: the purpose of this study is to investigate the role of haemophilus influenzae and other bacteria in causing chronic cough, through a direct comparison of chronic cough cases and healthy controls recruited from paediatric respiratory clinics in the united kingdom.


Eligibility criteria:
inclusion criteria: * subjects who the investigator believes that parent(s)/ legally acceptable representative can and will comply with the requirements of the protocol. * a male or female child between, and including, six to 72 months of age at the time of enrolment. * written informed consent obtained from the parent(s)/ legally acceptable representative of the subject. * no antibiotic therapy within four weeks prior to the visit. * no cystic fibrosis or known major immunodeficiency such as agammaglobulinaemia, t cell deficiency or human immunodeficiency virus / acquired immune deficiency syndrome. * no documented evidence or suspicion of gastroesophageal reflux disease. * no evidence of an upper viral respiratory infection four weeks prior to the visit. in addition, all subjects regarded as 'cases' must satisfy all the following criteria at study entry: * persistent cough greater than eight weeks. * no response to five-day prednisolone treatment. * chest x-ray showing no evidence of a lobar pneumonia or gross structural abnormality. in addition, all subjects regarded as 'controls' must satisfy the following criteria at study entry: * no respiratory symptoms four weeks prior to the visit. * no documented evidence or suspicion of lung disease upon physical examination. exclusion criteria: * concurrently participating in another study, at any time during the study period, in which the subject has been or will be exposed to an investigational or a non-investigational product. * use of any investigational or non-registered product within 30 days prior to study procedures, or planned use during the study period. * any confirmed or suspected immunosuppressive or immunodeficient condition, based on medical history and physical examination. * child in care.

Keywords: chronic cough haemophilus influenzae
a study of subcutaneous injection in healthy participants

Conditions: Healthy

Summary: the goal of this exploratory study is to learn about the effects of subcutaneous injections on healthy participants. the study aims to explore how different delivery methods containing a solution impacts injection pain, without an active drug to complicate the results. pain assessments will be performed visually and at the injection site to determine the level of pain experienced after each injection. this study will last approximately 40 days, including screening, assessment, and follow-up.


Eligibility criteria:
inclusion criteria: * are healthy as determined by medical evaluation including medical history and physical examination * have a waist circumference, measured around umbilicus, of at least 78 centimeters (cm) for participants assigned male at birth, and at least 71 cm for participants assigned female at birth * have a bmi within the range of 21.0 to 30.0 kilograms per square meter (kg/m²) * participants assigned female at birth must be of non-childbearing potential and must test negative for pregnancy prior to injection on day 1 exclusion criteria: * have known allergies to hyaluronic acid, related compounds, or any components of the formulation, or history of significant atopy. components of the formulation include, but are not limited to, sodium hyaluronate, sodium chloride, and sodium phosphate * have a history of severe injection-site reactions * have current or previous history of anaphylaxis * have tattoos or scars over the abdomen, or other factors, for example excessive folds of skin, that, in the investigator's opinion, would interfere with injection site assessments * have self-perceived dullness or loss of sensation on either side of the body and the abdomen * have a history or presence of a bleeding, wound healing (including diabetes), or fibrotic disorder * have known or ongoing psychiatric disorders
topical timolol 0.5% in atrophic acne scar

Conditions: Acne Scars - Mixed Atrophic and Hypertrophic

Summary: the aim of the study is to evaluate the efficacy and safety of microneedling combined with topical timolol 0.5% in the treatment of atrophic acne scars.

acne vulgaris (av) is a common chronic inflammatory disease of skin that develops from sebaceous glands associated with hair follicles. typically av begins at puberty and may continue through adulthood affecting the comedogenic areas of face, back and chest (mazzetti et al., 2019). one of the undesirable outcomes of acne is acne scars that are divided into two main types based on a loss (atrophic) or gain (hypertrophic) of collagen. atrophic type is the most common type, further subdivided into three subtypes: icepick, boxcar and rolling scar (bahl et al., 2020). post acne scars occur in nearly 75% of patients with acne affecting both male and female equally (khunger and kumar, 2012). acne scars impair quality of life and may be a risk factor for depression, suicide, low academic performance and unemployment (sood et al., 2020). there are different therapeutic modalities for atrophic acne scars including microneedling, chemical peeling, laser, filler, surgical procedures (punch excision, punch grafts) and fat transfer (pavlidis and katsambus, 2017). microneedling is considered safe for all skin types. it is performed by dermapen or dermaroller to induce new collagen formation that remains for a few months after the procedure (cohen and elbuluk, 2016). microneedling enhances the effect of topical preparations when used combined with them due to increasing their absorption by creating small channels through the epidermis to the dermis (jaffe, 1981). ghassemi et al. (2021) observed that application of 0.5% timolol after tca-cross caused a slight increase in scar improvement with more physician and patients' satisfaction. timolol, a beta-adrenergic receptor blocker, improves healing of skin wounds by increasing the phosphorylation of extracellular signal regulated kinases (erk) leading to keratinocyte migration (zeigler et al., 1999). also, erk initiate signaling cascades leading to fibroblast mitosis and proliferation with regulation of fibroblast functions in replacement of disorganized collagen and the reposition of the extracellular matrix (de araújo et al., 2019).

Eligibility criteria:
inclusion criteria: 1. all types of facial atrophic acne scars 2. patients aged \>18 years 3. both sexes exclusion criteria: 1. pregnancy and lactation 2. active acne or any active facial lesion 3. history of keloid scar 4. history of systemic diseases as dm or hypotension 5. bleeding and coagulation disorders 6. infection and immunosuppression
impact of idiopathic scoliosis on balance and footprint symmetry in adolescents

Conditions: Scoliosis Idiopathic

Summary: adolescent idiopathic scoliosis (ais) is the most prevalent form of scoliosis that affects children after the age of 10 years and is considered a critical developmental stage of the musculoskeletal system of the child. ais causes deviations in the cns, leading to asymmetry of motor activity and, consequently, an incorrect position of the spine. the progressive deformation of the spine leads to increased asymmetry in body functions. this elevated asymmetry is understood by the nervous system as a norm, which causes children to cease to sense the correct body position that may affect both static and dynamic balance and the foot pressure symmetry of the child, which was not investigated in such cases in any previous studies till now.


Eligibility criteria:
inclusion criteria: * asymptomatic children and adolescents ages 10 to 18 years * confirmed through x-rays; we focused on patients in growing age. * adolescent idiopathic scoliosis that has a cobb angle of 10° to 50° exclusion criteria: * neuromuscular etiology (e.g., cerebral palsy, myelomeningocele, muscular dystrophy, spinal muscular atrophy, spina bifida, spinal cord injuries) * early-onset idiopathic etiology (infantile \[ages 0 to 3 years\] or juvenile \[ages 4 to 9 years\]) * congenital etiology (e.g., hemivertebrae, failure of segmentation) mesenchymal/syndromic etiology (e.g., marfan syndrome, mucopolysaccharidosis, osteogenesis imperfecta, inflammatory diseases, postoperative)

Keywords: foot print scoliosis balance
clbp single-arm long-term follow-up study

Conditions: Chronic Low Back Pain

Summary: this is a prospective, noninterventional, observational post market data collection of long-term effectiveness and satisfaction outcomes for "a prospective, open-label, single-arm study of intraosseous basivertebral nerve ablation for the treatment of chronic low back pain (clbp single-arm study)" population at three (3), four (4), and five (5) years post intracept procedure. the working hypothesis is that data collected in this study will demonstrate safety, efficacy, durability and reproducibility of bvn ablation treatment outcomes out to 3, 4, and 5-years post-procedure.

patients were originally enrolled under nct03266107 and followed through 12-months post intracept procedure. this study approached patients from nct03266107 to collect additional long-term effectiveness and satisfaction outcomes at three (3), four (4), and five (5) years post intracept procedure.

Eligibility criteria:
inclusion criteria: - patient received the intracept procedure while participating in "a prospective, open-label, single-arm study of intraosseous basivertebral nerve ablation for the treatment of chronic low back pain (clbp single-arm long-term study)" exclusion criteria: - none

Keywords: vertebrogenic chronic low back pain intraosseous basivertebral nerve ablation low back pain axial low back pain
the effect of sacral surface electrical stimulation for assisted reproductive technology

Conditions: Infertility

Summary: the purpose of this study is to determine whether sacral surface electrical stimulation is effective in the treatment of assisted reproductive technology.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of infertility
image narrative with college students

Conditions: Depression, Anxiety

Summary: the pi developed the image narrative intervention (ini) based on the research using visual images in which visual images and narratives were found to support trauma survivors in narrating their experiences and in meaning making. the proposed study is the first study to test the therapeutic effect of the ini program. the investigators propose to assess, both qualitatively and quantitatively, the feasibility and preliminary effect of the ini through a pilot randomized control trial (rct) design with a wait list control.

aim 1. to understand the unique experiences of emerging adult college students during the covid-19 pandemic (especially around the themes of the self, relationships with others, and the future). aim 2. to evaluate the feasibility of the ini for emerging adult college students during the covid-19 pandemic, both quantitatively and qualitatively. aim 3. to evaluate the preliminary efficacy of the ini on distress, ptg, quality of life and meaning-making.

Eligibility criteria:
inclusion criteria: * 18-29 in age * college students at the university of utah * reporting moderate or higher levels of distress in dass21 exclusion criteria: -

Keywords: depression college students posttraumatic growth meaning making quality of life
ciclosporin to protect renal function in cardiac surgery

Conditions: Acute Kidney Injury

Summary: the purpose of this study is to evaluate the potential of ciclosporin in reducing risk and degree of acute kidney injury after cardiac surgery.

acute kidney injury (aki) is a common complication after cardiac surgery and is associated with decreased long-term survival. the mechanism for inducing acute kidney injury is unknown but ischaemia-reperfusion injury is indicated to be a part of the cause. animal studies have showed cytoprotective, preconditioning and anti-apoptotic effects of ciclosporin in ischaemia-reperfusion injury in the kidney. the major mechanism is thought to be inhibition of the reperfusion triggered opening of the mitochondrial permeability transition pore (mptp), responsible for reperfusion-induced necrosis. during cardiac surgery, the period of extracorporeal circulation (ecc) changes the perfusion through the kidney. return to normal perfusion with a beating heart has similarities with reperfusion following ischemia. administration of ciclosporin in conjunction with percutaneous coronary intervention (pci), heart surgery and traumatic brain injury (tbi) in humans has shown to be safe with no direct side-effects. the investigators therefore hypothesize that a preconditioning effect of ciclosporin before coronary artery bypass grafting (cabg) can reduce the level of renal dysfunction after this type of cardiac surgery.

Eligibility criteria:
inclusion criteria: * non-emergent cabg * written informed consent to participate * preoperative cyc egfr or mdrd egfr is 90-15. exclusion criteria: * uncontrolled hypertension * hypersensitivity to ciclosporin or any of the excipients of the lipid emulsion, including egg-, soya- or peanut protein * pregnancy or fertile woman * ciclosporin treatment within 4 weeks * ongoing malignancy, ongoing immunosuppressive treatment, severe hepatic dysfunction, dialysis or severe infection * ongoing medication with dabigatran, aliskiren, bosentan, stiripentol, glibenclamid, st john's worth, or * off-pump surgery

Keywords: ciclosporin acute kidney injury cardiac surgery ischemia safety cystatin c
effect of st. john's wort in the treatment of recurrent aphthous stomatitis

Conditions: Stomatitis, Aphthous

Summary: the aim of the treatment of recurrent aphthous stomatitis (ras) is to accelerate the healing of ulcers by reducing pain and inflammation, thus enabling patients to perform their oral functions comfortably. it has been said many times in the literature that st. john's wort is very effective in wound healing.in this study, the evaluation of the therapeutic effects of st. john's wort extract on the clinical symptoms and ulcer healing rate in patients with recurrent aphthous stomatitis (ras), a condition with no definitive treatment, was aimed.

he etiology of recurrent aphthous stomatitis (ras) remains incompletely understood. various therapeutic approaches, including topical and systemic agents, have been employed to alleviate pain, reduce ulcer dimensions, and prolong disease-free intervals. first-line management of ras typically involves topical pharmacological agents. among these, triamcinolone acetonide (ta), a corticosteroid derivative, is extensively utilized in the treatment of moderate-to-severe ras due to its anti-inflammatory properties. hyaluronic acid (ha) gel, a more recent therapeutic option, has been demonstrated to effectively mitigate pain associated with ras without inducing systemic or local adverse effects. furthermore, hypericum perforatum (st. john's wort) has gained significant attention in the scientific community owing to its pharmacological properties, including antiviral, antibacterial, antioxidant, and anti-inflammatory effects. studies evaluating the topical application of hypericum perforatum extract in wound healing have indicated that it significantly enhances tissue repair and regeneration. this study aims to compare the efficacy of triamcinolone acetonide, hyaluronic acid gel, and hypericum perforatum extract in pain management and ulcer size reduction in patients with ras.

Eligibility criteria:
inclusion criteria: 1. 18 years and over 2. having a history of ras for at least 2 years 3. having one in an easily accessible area in the mouth 4. ras has not exceeded a period of 48 hours exclusion criteria: 1. having any allergic history to these substances to be applied 2. during pregnancy and lactation 3. use of steroids, vitamins, antibiotics, antihistamines, oral retinoids or immune system regulating agents for ulcer treatment within 3 months 4. the patient has a history of systemic disease

Keywords: rehabilitation hypericum perforatum pain hyaluronic acid corticosteroid