Kornimate/medical-research-clean huggingface dataset:
the effect of phototherapy treatment on oxygen saturation measurement in newborns

Conditions: Hyperbilirubinemia, Neonatal Indirect

Summary: this will be a prospective clinical study conducted with the approval of the clinical research ethics committee. the influence of phototherapy lights on the accuracy of pulse oximetry will be investigated.

each patient's oxygen saturation will be measured non-invasively via a nondisposable polyethylene neonatal probe taped to the infant's palm, toe, or dorsum of the foot. the probe will be connected to an massimo rad97 pulse oximeter that is standardized at the factory. it runs through an automatic systems check when turned on and needs no further calibration before being used. the oxygen saturation measurements will be considered valid when there will be a normal plethysmographic waveform, a fullscale signal strength bar, and a stable heart rate closely approximating an independent electrocardiographic (ecg) pulse rate. the pulse oximeter works by using the technology of plethsmography which allows the detection of an arterial pulse) with oximetry (which measures oxygen saturation at specific wavelengths). the pulse oximeter will be placed on each infant as already described. after a stable pulse oximeter reading was obtained, the value will be recorded ("before") and then the probe will be covered with a standard disposable diaper, shiny side up. when the reading stabilized, the value will be recorded ("during") and then the diaper will be removed.

Eligibility criteria:
inclusion criteria: * newborn babies (0-28 days) * to be treated in the hacettepe university children's hospital neonatal intensive care unit * receiving phototherapy treatment exclusion criteria: * newborn babies with any diseases that affect oxygen saturation including congenital heart disease, chromosomal disease, inborn error of metabolism, anemia, circulatory disorder, hypovolemia or hydrops fetalis

Keywords: pulse oximeter, phototherapy, newborn
lazanda fentanyl nasal spray pre radiofrequency nerve ablations(rfa) of lumbar facet joints

Conditions: Minor Procedural Pain

Summary: the purpose of this study is to evaluate the effectiveness, feasibility and safety of intranasal fentanyl (lazanda) as an alternative to the current gold standard (diazepam) to produce anxiolysis and improve patient comfort during and after radiofrequency ablations of the lumbar facet joints. if this pilot study shows a positive effect and lazanda is found to be feasible and safe for use during procedures, future larger scale studies can be done.

the morning of the procedure/procedures the medication will be obtained from the omnicel by one of the qualified pain clinic study staff for the volunteers that have consented for that day. . it will be signed out on the designated form created for tracking and accountability purposes patient consent for study participation will be confirmed. once in the procedure room a dvprs (defense and veterans pain rating scale) baseline pain score and poss (pasero opioid-induced sedation scale) score will be assessed by a member of the research team. baseline non-invasive blood pressure, heart rate, and oxygen saturation will be documented and continuous monitoring of these vital signs will commence by a provider credentialed by wamc (womack army medical center) to perform anxiolysis with documentation every 15 minutes until discharge. a qualified rn (registered nurse), or physician will administer 100 mcg of lazanda ten-fifteen minutes prior to the procedure the administration will be witnessed and confirmed on appendix d. the unused 7 mcg will be wasted in a charcoal filled bag provided by the manufacturer and that bag will be disposed of per hospital policy. the waste will also be witnessed and noted. the pasero opioid-induced sedation scale and a dvprs pain score will be assessed every 15 minutes through the conclusion of the procedure and every 15 minutes up until discharge or for 1 hour post procedure whichever comes first. if naloxone is required during the procedure this will be noted as well. any adverse or serious adverse events will be reported per regulatory regulations.

Eligibility criteria:
inclusion criteria: * male and female patients asa(american society of anesthesiologist physical classification system) i-iii * 18 years of age and older referred for lumbar facet rfa (radio-frequency ablation) by womack ipmc (interdisciplinary pain management center) exclusion criteria: * known allergy to fentanyl or naloxone * diagnoses of allergic rhinitis with active rhinorrhea * pregnant or breastfeeding * asthma or copd (chronic obstructive pulmonary disease) that requires frequent rescue medications. * hepatic insufficiency with abnormal liver enzymes * noted decreased mental function * heart rate under 50 or bp below 90 systolic and/or 60 diastolic * myasthenia gravis diagnoses * acute narrow angle glaucoma * allergy to meperidine * on medications with a known dangerous drug interactions to fentanyl

Keywords: intranasal fentanyl conscious sedation
effects of olive oil and mlct on glycolipid homeostasis in patients with metabolic syndrome

Conditions: Hyperlipidaemia; Metabolic Syndrome

Summary: the type of cooking oil used is a crucial factor influencing dietary quality. the purpose of this study is to investigate the effects of olive oil and mlct oil intervention on glucose and lipid homeostasis in patients with mets.

we conducted a 6-month rct to evaluate the effects of olive oil and mlct as cooking oils on glucose and lipid homeostasis in patients with mets; investigate the changes in lipoprotein subfractions and metabolites using nmr spectroscopy, alongside gut microbiota alterations, to elucidate potential mechanisms; and identify baseline variables associated with the anti-obesity effects of olive oil and mlct.

Eligibility criteria:
inclusion criteria: participants eligible for the study were those with a confirmed mets diagnosis according to the idf criteria53, aged between 40 and 70, and who reported infrequent consumption of meals outside the home (≤3 times per week) exclusion criteria: (i) current breastfeeding or pregnancy; (ii) history of cardiovascular disease, including heart disease, coronary artery disease, stroke, cerebral infarction, viral hepatitis (e.g., hepatitis a or b), chronic kidney disease (estimated glomerular filtration rate \[gfr\] \<60 ml/min), or malignancy; (iii) presence of diabetic ketoacidosis or hyperketonemia; (iv) recent alterations in prescribed medication within the previous 6 months; (v) current use of insulin therapy; (vi) consumption of mlct in the preceding 6 months; (vii) participation in other clinical research studies within the last 6 months; and (viii) premenopausal women

Keywords: olive oil mlct oil plasma metabolome gut microbiota
changing the paradigm of in-hospital cardiopulmonary resuscitation

Conditions: Oxygen Dependent COPD; Advanced Malignancy

Summary: outcomes after in-hospital cardiopulmonary resuscitation (cpr) are very poor, particularly in patients with oxygen dependent chronic obstructive pulmonary disease (copd) or metastatic cancer. recent work found that in-hospital cpr is being performed more often before death with unchanging survival and that fewer cpr survivors are being discharged home, thus suggesting that cpr is increasingly performed without benefit and that the burden of this ineffective treatment is increasing. unlike other medical procedures, cpr has become the default provided to all patients even those with tremendously poor outcomes. it is time to change the paradigm of cpr. through comparing an innovative "informed assent" approach toward in-hospital cpr (informing patients that their underlying chronic illness makes outcomes of cpr so poor that cpr is not performed while allowing them to disagree) versus usual care in a group of chronically ill patients with reduced life expectancy, the investigators aspire to demonstrate that cpr delivery can be reduced. and in addition that dnr status increases, while preserving patient quality of life and decreasing the burden of this ineffective treatment to both patients and families. if effective, this informed assent intervention has the potential to revolutionize how the investigators discuss cpr with the investigators chronically ill patients.


Eligibility criteria:
inclusion criteria: * 18 years or older * oxygen dependent copd or advanced malignancy * life expectancy of less than two years exclusion criteria: * subjects who have already firmly decided to undergo cpr * subjects enrolled in a hospice program * subjects unable to speak english * subjects incapable of making their own decisions at the time of enrollment * subjects cared for by the study investigator

Keywords: cpr palliative outcome
retinal microvascularization and cardiovascular disease

Conditions: High Cardiovascular Risk Patients; Low Cardiovascular Risk Patients

Summary: the main objective of this study is to investigate whether there are links between the blood vessels of the retina as a whole and heart and/or vascular diseases (cardiovascular diseases). the arteries and veins of the retina are, like the large vessels of the human body (aorta, coronary, cerebral arteries), exposed to the complications of hypertension, diabetes, obesity, dyslipidemia (abnormal blood lipid profile) or tobacco. several studies have shown that changes in retinal vessels (microvascularization) generally occur several years before damage to large peripheral vessels (macrovascularization). the study of the vessels of the retina is now possible thanks to simple and non-invasive examinations of photographs (not creating any lesion). they allow a painless evaluation of the vessels in the retina. ultimately, if this study is conclusive, the patient's cardiovascular risk could be evaluated simply by analysis of the vessels of the retina. the study is being conducted in the ophthalmology and cardiology departments of dijon university hospital. in total, the investigators wish to include approximately 510 patients who present cardiovascular risk factors (255 low risk patients recruited in the ophthalmology department and 255 high risk patients hospitalized in the cardiology department). all patients participating in the study will be asked to visit the ophthalmology department for a complete examination of the retina.


Eligibility criteria:
inclusion criteria: * person who gave oral consent * high cardiovascular risk group: adult patients hospitalized in the cardiology department of the university hospital of dijon burgundy for acute coronary syndrome, patients between d1 and d5 of acute coronary syndrome, who can be moved for an ophthalmology consultation where the retinal imaging is done (heart monitoring in the presence of an experienced cardiologist if necessary) * low cardiovascular risk group: adult patients over 40 years of age recruited in the ophthalmology department of the university hospital of dijon burgundy following a standard consultation for cataract surgery, ocular surface pathologies and optical correction. exclusion criteria: * person not affiliated to national health insurance * patient refusal * minor patient * protected patient * ophthalmological history (macular vascular or degenerative disorders)
biomarker study in participants with migraine

Conditions: Migraine Disorders

Summary: this is a study of participants with a diagnosis of migraine who completed another clinical trial nct02163993. the participants received either ly2951742 or placebo. this study nct02766517 will evaluate how certain biomarkers may be related to the participant's response in study nct02163993. the study will last about five days.


Eligibility criteria:
inclusion criteria: * participants with migraine who have previously participated in study ntc02163993 and received one of the selected doses of galcanezumab or placebo * have suitable skin characteristics for the dermal capsaicin challenge exclusion criteria: * have a history of significant allergies, in particular to ethanol or sensitivity to the fruits of capsicum plants (for example, chili peppers) * have eczema, scleroderma, psoriasis, dermatitis, keloids, tumors, ulcers, burns, flaps, or grafts on their forearm or other abnormality of the skin which may interfere with the study assessments * cannot avoid excess tanning (any exposure to sunlight or a tanning bed which would cause a sunburn reaction) throughout the study and cannot cover forearms for 24 hours prior to each treatment period * have excessive hair growth on the volar surface of the forearm or participants currently using lotions, oils, depilatory preparations, or other topical treatments on a regular basis which cannot be discontinued for the duration of the study; has used any topical treatments within 7 days of the start of the study
two different approaches during fluoroscopically guided interlaminar lumbar epidural steroid injection

Conditions: Unilateral Lumbosacral Radiculopathy Pain

Summary: the purpose of this study is to compare two different approaches (midline and parasagittal) during interlaminar lumbar epidural steroid injection (lesi), and to verify the role of concordant pressure paresthesia occurring during the lesi in determining outcome. the investigators are planning to include 100 patients, undergoing lesi for radicular low back pain. this will be single-blinded randomized study. every patient will receive the same medication we would use regardless of participating in the study. the patients will be randomly assigned to one of two groups, based on the approach: * group i (50 patients) - will get lesi using midline (mil) approach. * group ii (50 patients) - will get lesi using parasagittal interlaminar (pil) approach.


Eligibility criteria:
inclusion criteria: * 18- 80 years old * history of low back pain and unilateral lumbosacral radiculopathy pain * lumbar disk disease including disk herniations, bulging discs, and degenerated discs, where at least 50% of the disk height is preserved respective to contiguous levels exclusion criteria: * discogenic pain without radiculopathy pain * history of previous spinal surgery * lesi(s) in the past year * allergy to methylprednisolone, or lidocaine, or iodine-based contrast * concurrent use of systemic steroid medications * opioid habituation * pregnancy
dome-type (modified c-incision) manual morcellation during laparoscopic uterine surgery

Conditions: Surgical Procedure, Unspecified

Summary: in-bag manual morcellation is a safe alternative procedure after fda's discouragement of electronic power morcellator. the traditional wedging (v-type incision) or semicircular coring (c-type incision or excite) method are the most common morcellation techniques. for beginners, it is somehow not that easy to get familiar with these methods. no teaching or learning experiences were reported. therefore, we developed a dome-type (modified c-incision) technique to manually morcellate uteri leiomyoma or uterus at the time of laparoscopic surgery and report perioperative outcomes and the learning experiences of our residents for this technique from our two years of experience.

background: in-bag manual morcellation is a safe alternative procedure after fda's discouragement of electronic power morcellator. the traditional wedging (v-type incision) or semicircular coring (c-type incision or excite) method are the most common morcellation techniques. for beginners, it is somehow not that easy to get familiar with these methods. no teaching or learning experiences were reported. objective: to describe using a dome-type (modified c-incision) technique to manually morcellate uteri leiomyoma or uterus at the time of laparoscopic surgery and report perioperative outcomes and the learning experiences of our residents for this technique from our two years of experience. study design: retrospective review of consecutive laparoscopic myomectomies or hysterectomies performed between may 2020 and september 2022 in which the specimen was manually morcellated using the dome-type technique by surgeon or trainees.

Eligibility criteria:
inclusion criteria: * women at any age undergoing laparoscopic surgeries with dome-type morcellation exclusion criteria: * women with extremely huge specimen (\>2000 gm)
assessment of physical functioning and handling of spiolto® respimat® in patients with chronic obstructive pulmonary disease (copd) requiring long-acting dual bronchodilation in routine clinical practice

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: the primary objective of the study is to measure changes in physical functioning - serving as a surrogate for physical activity and exercise capacity - in copd patients being treated with spiolto® respimat® after approximately 6 weeks. a secondary objective is to evaluate the patient¿s general condition (physician¿s evaluation) at visit 1 (baseline visit at the start of the study) and at visit 2 (final visit at the end of the study, approx. 6 weeks after visit 1), as well as patient satisfaction with spiolto® respimat® at visit 2.


Eligibility criteria:
inclusion criteria: 1. written informed consent prior to participation 2. female and male patients = 40 years of age 3. patients diagnosed with copd and requiring long-acting dual bronchodilation (lama + laba) treatment according to approved spiolto® respimat® smpc and copd gold guideline recommendation exclusion criteria: 1. patients with contraindications according to spiolto® respimat® smpc 2. patients who have been treated with a laba/lama combination (free and fixed dose) in the previous 6 months 3. patients continuing laba- inhalative corticosteroides (ics)treatment should not be additionally treated with spiolto® respimat® in order to avoid a double dosing of long-acting beta-agonists 4. patients for whom further follow-up is not possible at the enrolling site during the planned study period of approx. 6 weeks 5. pregnancy and lactation 6. patients currently listed for lung transplantation 7. current participation in any clinical trial or any other non-interventional study of a drug or device
biomarkers in samples from younger patients with wilms tumor

Conditions: Wilms Tumor and Other Childhood Kidney Tumors

Summary: this research study is studying biomarkers in tissue samples from younger patients with wilms tumor. studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. it may also help doctors predict how patients respond to treatment

primary objectives: i. to determine whether recruitment of tumor-associated macrophages is related to clinicopathological factors in wilms tumor (tumor stage, presence of vascular invasion, tumor progression, and survival). outline: paraffin-embedded specimens are analyzed for macrophage markers. results of each sample are then compared with patient's tumor stage, presence of vascular invasion, tumor progression, and survival.

Eligibility criteria:
inclusion criteria: * wilms tissue microarray samples provided by the children's oncology group
integrating palliative care for patients with idiopathic pulmonary fibrosis and their caregivers

Conditions: Idiopathic Pulmonary Fibrosis

Summary: patients with idiopathic pulmonary fibrosis (ipf) and their caregivers will be randomized to receive this intervention or usual care. the intervention will include information about the disease, self-management strategies, and introduction to advanced care planning in a format with enhanced content available across multiple domains (face-to-face, printed material, digital (tablet) delivered by an interventionist. the usual care group will be provided with routine printed patient education. at the end of life, ipf patients and their caregivers experience stress, symptom burden, poor quality of life, and inadequate preparedness for end-of-life care planning. the proposed study will measure feasibility, acceptability, and impact of a supportive care intervention.

idiopathic pulmonary fibrosis (ipf) is a disease of aging associated with intense medical and financial burden and expected to grow in incidence within the us population. median survival from diagnosis is 3.8 years, although some patients succumb to a rapid death within 6 months. new therapies have recently become available. while these medications slow the rate of pulmonary deterioration, they have no impact on ultimate survival or quality of life. although transplantation is an effective surgical therapy, less than 20% of patients ever receive a lung transplant. the remaining 80% have few treatment options and a likely rapidly progressive downhill course. despite the fatal prognosis, we have found that patients and caregivers often fail to understand the poor prognosis as the disease relentlessly progresses. at the end of life, ipf patients and their caregivers experience stress, symptom burden, poor quality of life, and inadequate preparedness for end-of-life care planning. the proposed study will measure feasibility, acceptability, and impact of a supportive care intervention. patients with ipf and their caregivers will be randomized to receive this intervention or usual care. the intervention will include information about the disease, self-management strategies, and introduction to advanced care planning in a format with enhanced content available across multiple domains (face-to-face, printed material, digital (tablet) delivered by an interventionist. the usual care group will be provided with routine printed patient education.

Eligibility criteria:
inclusion criteria: * 45 years or older * primary diagnosis of with idiopathic pulmonary fibrosis (ipf) * has a caregiver, 18 years or older (spouse/partner/child/family member/friend), willing to participate. * sees a simmons center physician for usual ipf care. exclusion criteria: * less than 45 years * not diagnosed with ipf * has an unwilling caregiver, or a caregiver under 18. * does not see a simmons center physician for usual ipf care.

Keywords: idiopathic pulmonary fibrosis fibrosis ipf caregivers pulmonary palliative end of life idiopathic