Kornimate/medical-research-clean huggingface dataset:
effect of testosterone replacement on insulin resistance

Conditions: Metabolic Syndrome; Hypogonadism

Summary: this study aims to determine whether testosterone replacement improves insulin sensitivity in non-obese men with low testosterone and the metabolic syndrome. the metabolic syndrome includes three of the following five conditions, 1) an elevated blood pressure (greater than 130/85), 2) a triglyceride level greater than 150 mg/dl, 3) an hdl-cholesterol less than 40 mg/dl, 4) glucose levels greater than 100 mg/dl, and 5) a waist measurement greater than 40 inches.

in this proposal, we will examine the relationship between hypogonadism and insulin sensitivity. the strongest relationship between hypogonadism and insulin resistance appears to reside in men with the metabolic syndrome who have a normal bmi. the causal relationship between these two conditions is unknown. therefore, we propose to determine if testosterone replacement in hypogonadal non-obese men with metabolic syndrome will improve insulin sensitivity. data obtained from this preliminary investigation, will hopefully result in a hypothesis that can be tested in a larger, more rigorous trial in the future.

Eligibility criteria:
inclusion criteria: (subjects must meet both criteria) * metabolic syndrome (have 3 out of the following 4 criteria): 1. bp \> 130/85 or on antihypertensive therapy 2. fasting glucose \> 100 mg/dl 3. fasting tg \> 150 mg/dl or on a triglyceride lowering agent (fenofibrate, gemfibrozil, niacin in doses of \>= 500 mg/day, or fish oils in doses of \>=2000mg dha+epa) 4. fasting hdl-c \< 40 mg/dl note that the waist circumference will not be used as one of the criteria for the metabolic syndrome for this study because we are studying non-obese subjects. * total testosterone less than 300 ng/dl exclusion criteria: * women. * men less than 20 years of age. * bmi \> or = to 30 kg/m2. * use of testosterone preparations within 1 year of the screening visit * use of hypoglycemic medications within the previous 3 months. * fasting blood glucose \> 126 mg/dl. * the following men will be excluded because of the potential safety issues in the placebo treated group: 1. creatinine greater than 1.4 mg/dl 2. triglyceride levels greater than 500 mg/dl 3. hdl-c levels less than 20 mg/dl 4. blood pressure greater than 160/90 * the following men will be excluded because of the potential side effects of testosterone therapy: 1. men greater than 65 years of age 2. international prostate symptom score \>19 3. psa greater than 2.5 4. history of benign prostatic hypertrophy 5. history of prostate cancer 6. abnormal digital rectal exam 7. hg greater than 16 mg/dl or hct greater than 48% 8. peripheral edema

Keywords: metabolic syndrome hypogonadism insulin resistance
coping strategies with pain among older people

Conditions: Pain

Summary: chronic musculoskeletal pain is common among older adults. this study aimed to identify and describe the characteristics of chronic musculoskeletal pain, pain management and coping strategies among older adults from turkey, croatia and romania. the study also aimed to explore cultural differences in pain experience and management. methods: 337 older adults with chronic pain participate 100 from turkey, 131 from croatia and 106 from romania. semi-structured interviews will explore four main topics, including factors influencing pain, coping strategies, management strategies, and health-related quality of life.

the questionnaire which was prepared by researchers will be performed by older adults. the sociodemographic characteristics are recorded to part a section of questionnaire. the pain assessment section is part b and evaluate pain localization, intensity, type, factors affecting the pain, coping and management strategies of pain. health related outcomes will be evaluated with cdc (center of disease control and prevention) health related quality of life-4 questionnaire

Eligibility criteria:
inclusion criteria: * women and men aged between 65-85 years * living in their own homes or in a nursing home * older adults with chronic pain for at least 6 months, * independent in activities of daily living, and independent in walking (with or without assistive walking devices). exclusion criteria: * elderly adults with communication problems

Keywords: aged coping strategy health-related quality of life
effects of dietary and weight management on pregnancy outcomes in mobile medical platform

Conditions: Gestational Diabetes Mellitus; Hypertensive Disorder of Pregnancy

Summary: with the opening up of the two-child policy , the composition of pregnant women in china has changed significantly . the proportion of high-risk pregnant women in the elderly has increased significantly , and the risk of adverse pregnancy outcomes has also increased . among them , gestational diabetes mellitus ( gdm ) is the most common complication during pregnancy . the incidence of gdm in china is as high as 18 % due to the economic growth , lifestyle changes and dietary habits . gdm not only threatens perinatal maternal and child health , but also increases the risk of offspring insulin resistance , obesity and metabolic diseases in adulthood . but it is still lack of experience on intervening and managing them effectively. therefore , on the basis of previous studies , this study intends to explore the effects of intensive diet and exercise intervention by obstetricians and nutritionists on pregnancy weight gain , pregnancy outcome , glucose and lipid metabolism and postpartum weight retention under the mobile medical platform through a large sample cluster intervention test in the real world. in order to supervise and improve the compliance of the intervention subjects and realize the ultimate change of their behaviors, this study intends to use the app software, the mobile medical technology, to monitor and evaluate diet , exercise and weight. through the above research , it aims to improve the current management schemes of diet and weight during pregnancy , not only helps to optimize and improve the quality of perinatal health care , but also prevents the adult chronic diseases from the fetal period. this research has important theoretical and practical value .

this is a cluster intervention study. a randomized controlled trial in pregnant women will be initiated at 8-12 weeks of gestation util delivery. pregnant women who received routine antenatal examination in beijing obstetrics and gynecology hospital will be divided into two groups . one group contained 1000 cases as the control group , and the other group contained 1000 cases as a whole . the intervention contents included health education , nutritional analysis and individualized dietary guidance combined with mobile medical treatment and face-to-face teaching during the early , middle and late pregnancy stages. the primary outcome will be the incidence of gdm and the secondary outcome will be the incidence of hypertensive disorders of pregnancy , cesarean section , premature delivery , macrosomia, large for gestational age and so on.

Eligibility criteria:
inclusion criteria: * regular check-ups in our hospital * 18-44 years old * 8-12 gestational weeks exclusion criteria: * patients with incomplete medical records
the effect of intra-articular pulsed radiofrequency in osteoarthritis

Conditions: Osteoarthritis

Summary: pulsed radiofrequency (prf) is designed to alleviate pain by delivering an electrical field and heat bursts at a temperature less than 42°c to neural tissue. in contrast with conventional radiofrequency, prf is controlled below 42°c without damage to nerves and many studies have shown its benefits in pain relief for certain kinds of chronic pain conditions. for lessening pain of certain joint arthropathy, the direct nerve block by application of prf is difficult and complicated because the supplying nerve of joint is complex or small. hence, some authors perform intra-articular prf on the chronic painful joint for example, knee osteoarthritis, atlantoaxial joint, cervical facet joint sacroiliac joint, scapholunate and shoulder joint and the excellent long-term effects are reported. the purpose of this study is to investigate the effect of intra-articular prf in osteoarthritis.

pulsed radiofrequency (prf) is designed to alleviate pain by delivering an electrical field and heat bursts at a temperature less than 42°c to neural tissue. in contrast with conventional radiofrequency, prf is controlled below 42°c without damage to nerves and many studies have shown its benefits in pain relief for certain kinds of chronic pain conditions. for lessening pain of certain joint arthropathy, the direct nerve block by application of prf is difficult and complicated because the supplying nerve of joint is complex or small. hence, some authors perform intra-articular prf on the chronic painful joint for example, knee osteoarthritis, atlantoaxial joint, cervical facet joint sacroiliac joint, scapholunate and shoulder joint and the excellent long-term effects are reported. however, the definite effect of intra-articular prf for osteoarthritis from current published studies are insufficiently proved because of small patient numbers and lack of placebo-controlled design. the purpose of this study is to investigate the effect of intra-articular prf in osteoarthritis.

Eligibility criteria:
inclusion criteria: * age between 30-75 year-old * clear consciousness * no receive steroid injection, hyaluronic acid, platelet rich plasma in past 6 months * the pain (vas) more than 4 * symptom duration at least 6 months exclusion criteria: * cancer * joint contracture * coagulopathy * pregnancy * status of pacemaker * inflammation status * operative history of treated joint

Keywords: pulsed radiofrequency, osteoarthritis
impact of severe acute respiratory syndrome (sars-cov-2/covid-19) related pneumonia on lung function and structure.

Conditions: Covid19; SARS-CoV Infection; Pulmonary Function; Pneumonia, Viral

Summary: prospective study in a group of patients with covid-19 pneumonia.

objective: assessment of pulmonary and heart dysfunction, fibrosis-related markers and antibodies as well as the search for risk factors for an unfavorable course and possible complications in patients after pneumonia due to sars-cov-2 (covid-19) infection. patients: a group of approx. 100 patients assessed shortly after pneumonia and followed up, investigated after 3 and 6 months with possible prolongation to 12 months.

Eligibility criteria:
inclusion criteria: 1. confirmed sars-cov-2 infection with pneumonia hospitalized 2. two negative pcr results of a swab from the respiratory tract in succession, including the last one taken no later than 3 days before the planned lung function tests (1st visit). exclusion criteria: 1. lack of patient consent, 2. present contraindications for lung function tests 3. inability to perform correctly lung function measurements
aprepitant treatment to prevent postoperative nausea and vomiting in children undergoing scoliosis surgery

Conditions: Spinal Fusion; Nausea and Vomiting, Postoperative; Anesthesia

Summary: this research trial will measure how useful aprepitant is in preventing nausea and vomiting in children having surgery to correct scoliosis (curvature of the spine).

detailed description: this prospective, randomized, controlled trial will test whether adding aprepitant to standard multimodal therapy regimen can further reduce the incidence and severity of post-operative nausea and vomiting (ponv) in children undergoing posterior spinal instrumentation and fusion. the primary outcome of the study will be anti-nausea rescue medication administration post-surgery, with secondary outcomes being the first instance of post-surgery anti-nausea rescue medication administration, emesis, headache, flatus, bowel movement, and sensation of itch; incidence of treatment-emergent adverse events; and worst nausea and pain scores post-surgery .

Eligibility criteria:
inclusion criteria: * posterior spinal instrumentation and fusion (psif) for idiopathic scoliosis * the fusion must include at least 6 vertebral levels. * children greater than or equal to 8 years old, and less than 19 years old on the day of surgery * weight \> 40kg - for ease of pharmacy preparation (ponv dose 1mg per kg to max 40mg) exclusion criteria: * patient/ parent refusal * hypersensitivity to aprepitant or any ingredient in the formulation or oral solution. (previous allergy or adverse reaction to aprepitant) * developmental delay as reported by parents * pregnant - pregnancy test done as standard of care pre-operative * severe systemic disease asa classification iii or greater * concurrent use of any medication with severe interaction with aprepitant as outlined in product monograph. * neuromuscular or congenital scoliosis * inability to take po medications

Keywords: pediatric anesthetic scoliosis aprepitant
acute maternal hyperoxygenation for fetal transposition of the great arteries (tga)

Conditions: TGA - Transposition of Great Arteries

Summary: this prospective study will examine whether transient maternal hyperoxygenation is useful as a diagnostic test to more accurately detect tga patients with poor vs. good neonatal intra-cardiac mixing of blood, based on the in-utero response to oxygen exposure. this study is health canada regulated

this is a prospective pilot study to examine whether transient maternal hyperoxygenation is useful as a diagnostic test to more accurately detect tga patients with poor vs. good neonatal intracardiac mixing of blood, based on the in-utero response to oxygen exposure. acute maternal oxygen administration will transiently increase the fetal oxygen levels to those reached at birth with spontaneous breathing, thus simulating conditions that will naturally occur at the time of birth. echocardiogram and mri will be used to examine the effects on the fetal circulation. the prenatal findings will then be compared to the neonatal presentation. the investigators postulate that conditions that predispose newborns to acute neonatal compromise will be detectable and distinguishable prior to birth by echocardiography, mri, or by combining the findings of both exams.

Eligibility criteria:
inclusion criteria: * fetus with simple tga +/- small vsd * intention of active postnatal management after birth exclusion criteria: * fetus with complex form of tga * significant fetal arrhythmia * major non-cardiac lesions * maternal contraindications for fetal mri

Keywords: maternal hyperoxygenation fetal echocardiography fetal mri
physical telerehabilitation in veterans with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: the primary objective of this study will be to assess the feasibility and patient acceptance of a home automated telemanagement (hat) system in multiple sclerosis patients. our hypothesis is that home telemanagement will be effective and useful in the rehabilitation of multiple sclerosis patients. specifically, the investigators hypothesize that home telemanagement using a daily exercise diary, monitoring of compliance with a tailored exercise program and regular assessment of strength and motor functions will: 1. be feasible and acceptable in patients with multiple sclerosis 2. improve patient compliance with home exercise program 3. increase patient mobility and motor functions 4. be a feasible and effective mechanism for affecting multiple sclerosis patient self-efficacy 5. improve quality of life


Eligibility criteria:
inclusion criteria: * age: 18-65 * clinical diagnosis of ms based on mcdonald criteria * functional disability defined by the pdds in the range of 2 to 6 * have a working telephone line in their home or a cell phone * willingness and ability to use ms hat platform with individual modifications based on preferred user interface * patient demonstrates ability to successfully perform physical therapy exercises and procedures independently or with assistance of a caregiver. * ability to complete 25-foot walk test in at least 3 minutes exclusion criteria: * age less than 18 years old * no diagnosis of ms * other musculoskeletal diagnoses, unstable cardiovascular, respiratory, metabolic or other conditions that would interfere with this study * one or more exacerbations in the preceding 3 months * received a course of steroids (iv or oral) within 60 days of screening

Keywords: multiple sclerosis telerehablitation
a prospective registry for patients with non-tuberculous mycobacterial (ntm) pulmonary disease in korea.

Conditions: Pulmonary Disease; Pulmonary Infection; Non-Tuberculous Mycobacterial Pneumonia

Summary: the incidence and prevalence of pulmonary disease due to non-tuberculous mycobacteria (ntm) is increasing worldwide, and this trend has been confirmed in korea. treatment of ntm pulmonary disease is difficult and usually requires more than two years of long-term treatment, and the antibiotic regimens used in treatment vary. therefore, it is difficult to track the natural history of patients with ntm pulmonary disease, to evaluate the treatment outcome, and to understand the effect of specific medicines on the outcome. establishing a prospective registry of patients with ntm pulmonary disease is expected to accurately evaluate the progress, treatment modality, and treatment outcome of ntm pulmonary disease.


Eligibility criteria:
inclusion criteria: 1. clinical diagnosis of ntm pulmonary disease. 2. the causative agent of ntm pulmonary disease includes: m. avium complex, or m. abscessus subspecies abscessus, or m. abscessus subspecies massiliense, or m. kansasii. 3. patients who starts new treatment (those who have previous history of treatment are eligible) exclusion criteria 1. patients who have been treated for more than 4 weeks. 2. the causative agent of ntm pulmonary disease is none of m. avium complex, m. abscessus subspecies abscessus, m. abscessus subspecies massiliense, or m. kansasii.

Keywords: ntm registry pulmonary infection
superior vena cava reconstruction in patients on hemodialysis

Conditions: Superior Vena Cava Syndrome

Summary: the treatment objective for patients with svc syndrome secondary to both malignant and benign etiologies is to reduce the elevated central venous pressures.1 however, the strategies are contingent upon the underlying disease process. thus the management of svc syndrome ranges from medical or supportive care to surgical bypass,3 and it is important for physicians to understand the varied treatment modalities of this potentially life-threatening disease.17 fortunately, the overwhelming majority of patients with svc syndrome secondary to benign causes develop a physiologic compensation for the obstruction that can be treated with anticoagulation and endovascular modalities. intervention for symptomatic relief may not be required.1 an endovascular approach is the current standard of care to relieve svc obstruction due to malignancy to obtain prompt relief of the rapidly emerging symptoms and improve quality of life,3 keeping in mind the short life expectancy of these patients. the role of endovascular therapy in svc syndrome of nonmalignant etiology is undecided because the long-term durability of this treatment method remains to be assessed.

this case study will retrospectively review all svc syndrome and/or occlusion procedures since january 2009. all patients were given adequate informed consent about the procedure and its benefits and complications. definitions of clinical outcomes will adhere to the subcommittee on reporting standards in venous disease.27 risk factors and outcomes of these procedures will be retrospectively analyzed. data collected included preoperative patient demographics, clinical status, noninvasive and invasive imaging, operative procedural details, post-operative complications, post-procedural imaging surveillance, adjunctive/re-intervention procedures, clinical outcome during follow-up, and mortality. primary endpoints will be clinical outcome and patency. secondary endpoints will be re-intervention rate and death within 30 days.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * presence of svc syndrome or svc occlusion * presence of esrd on hemodialysis * presence of upper extremity or neck access, either catheter or surgical fistula * patients who have received endovenous or open bypass reconstruction of the svc secondary to svc syndrome or svc occlusion exclusion criteria: * patients who have not undergone endovenous or open bypass reconstruction of the svc secondary to svc syndrome or svc occlusion
effects of urban afforestation activity on pain mechanisms

Conditions: Healthy

Summary: this single-group pretest-posttest clinical trial aims to evaluate the effects of a single-session afforestation activity on pain thresholds.

participants will perform an afforestation activity for a single session of 90 minutes. the therapist will direct the participants' attention to the visual, auditory, olfactory, and tactile features of the surrounding environment. a battery of quantitative sensory tests pre- and post-intervention.

Eligibility criteria:
inclusion criteria: * free of pain in the hands, cheeks, lower back, wrists and trapezius muscles in the previous 3 months. * adults between 18 and 65 years. * any sex and gender. exclusion criteria: * intake of any analgesic or psychotropic medication. * other severe or medically unstable diseases that may interfere with participation. * severe cognitive impairment (mini-mental state examination score \< 17 out of 30 points). * severe mental disorders in the acute phase or symptomatic phase. * severe intellectual disability. * behavioural alterations as this may interfere with their participation. * pregnant or breastfeeding.

Keywords: green spaces nature-based activities horticultural therapy quantitative sensory testing pain mechanisms
validation of patient-reported outcomes measures for the assessment of gastroesophageal reflux disease (gerd) symptoms

Conditions: GERD; Acid Reflux Disease; Heartburn; Regurgitation

Summary: this research study is being done to gather information about how to do further clinical studies using azd3355 as an add-on treatment to proton pump inhibitors (ppi).


Eligibility criteria:
inclusion criteria: * subject able to read and write us english and able to use electronic devices * subjects who have experienced gerd symptoms for at least six months * subjects currently taking a prescription or over-the-counter ppi medications for gerd * body mass index (bmi) 18.5-35.0, inclusive exclusion criteria: * subjects that have not experienced any gerd symptoms improvement at all after ppi treatment * subjects who have any of the following conditions or diseases- heart disease, angina, seizure disorders such as epilepsy, congestive heart failure (chf), liver disease such as cirrhosis or hepatitis, kidney disease, lung disease or lung cancer, cancer * prior surgery of the upper gastrointestinal (gi) tract

Keywords: gerd acid reflux heartburn regurgitation non-acid reflux pro measures