Kornimate/medical-research-clean huggingface dataset:
robot-assisted training in children with cp

Conditions: Cerebral Palsy

Summary: cerebral palsy (cp) is the most common physical disability in early childhood causing serious motor and sensory impairments. effective interventions for the recovery of motor functions are of profound significance to children with cp, their families, caregivers, and health professionals. robot-assisted rehabilitation represents a frontier with potential to improve motor functions and induce brain reorganization in children with cp.

this study is designed to test whether robot-assisted hand training with amadeo improves manual functions and induces cerebral neural plasticity in children with cp. to evaluate the efficacy of the robot-assisted hand training, investigators will measure manual motor and sensory functions with behavioral tasks and assess neural activities in the sensorimotor cortical network with high-density electroencephalography (hd-eeg) and transcranial magnetic stimulation (tms) one day before, one day after, and two months after the robot-assisted training. the study will provide direct evidence on the effectiveness of the robot-assisted training in recovering of manual functions in children with cp. it will provide detailed insights on potential experience-dependent neuraplastic changes in the brain of children with cp. it has the potential to insight the development of more effective rehabilitation for children with cp and also children with other neurological disorders, like pediatric stroke. it may uncover factors that will be predictive of functional improvements in individual cp patient.

Eligibility criteria:
inclusion criteria: * an evaluation by a pediatric neurologist, physical medicine and rehabilitation (pmnr) physicians (physiatrists), neonatal developmental specialist, or neonatologist with a diagnosis of cp. * classified as high-functioning (i or ii) at the gross motor function classification system (gmfcs) * participants in the control group should have no history of neurological disorder or brain injury exclusion criteria: * psychoactive or myorelaxant medication during study procedures * genetic syndrome diagnosis * history of trauma or brain operation * inability to sit still * metal implants * baclofen pump * inability or unwillingness of patient or parent/legally authorized representative to give written informed consent
auricular acupressure for perimenopausal women with anxiety

Conditions: Auricular Acupressure; Anxiety; Menopause; Insomnia

Summary: this study is expected to show auricular acupressure therapy help to improve the anxiety symptoms of perimenopausal and early postmenopausal women, looking forward to developing a convenient, safe and effective way to reduce the use of sedative hypnotics and their dependencies, thereby improving their quality of life.

there are several stages of women while they were particularly vulnerable to anxiety and insomnia , especially in the pre-menstruation, pregnancy, postpartum, and menopause stage. sleep problems are common in menopausal and postmenopausal women, its prevalence can be based on research from 15% to 60%. as for anxiety, the prevalence of women in this population can reach 53.7%. several studies overseas have already pointed out that the improvement of acupuncture for anxiety disorders have had pretty good results. as auricular acupressure with a simple operation and the advantages of non-invasive, our interest is to explore the clinical benefit of combined auricular acupressure and medical therapy on anxiety and insomnia improvement in menopausal and early post-menopausal women. we design a double-blind, randomized controlled study, the subjects are ninety 40 to 60 years old women, during perimenopause and early postmenopause who are accompanied by anxiety symptoms. they were randomly divided into experimental and control groups, use the tape of ear adhesive beads on shenmen and subcortical area of both ears after three meals and before bed for three minutes each area with alternating ears, twice a week to replace paste. a total treatment time is eight times and a total of four weeks. primary efficacy assessment (primary outcome measure) for the hamilton anxiety rating scale (hama) total score change. secondary efficacy assessments (secondary outcome measure) for: 1) menopause rating scale (mrs) scores; 2) short form health survey (sf-36) scores; 3) clinical global impression-severity (cgi-s) scores; and 4) clinical global impression-improvement (cgi-i) score changes.

Eligibility criteria:
inclusion criteria: * age between 40 to 60 years * irregular menstrual cycle less than 12 months or no menstrual cycle less than 10 years * fsh level\>= 14 iu/l * brief symptom rating scale total scores\>= 6 exclusion criteria: * severe medical conditions * substance dependence or abuse * contraindication of bzds * contraindication of acupressure * other primary anxiety disorder and major psychosis * use hormone therapy * use herb medicine

Keywords: acupressure perimenopause menopause anxiety life quality insomnia
a study to validate a new oral fluid/saliva antibody test for novel h1n1v influenza

Conditions: H1N1 Virus

Summary: at present influenza immunity can only be reliably confirmed by a blood test. this test is invasive for the patient. this study is intended to validate an oral fluid/saliva antibody test for the variant swine influenza h1n1. if such a test were available, this painless and non invasive test will improve direct clinical care to an individual as well as significantly help guide future public health management of the pandemic.


Eligibility criteria:
inclusion criteria: * participants of the clinical service evaluation of novel h1n1v vaccine * first or second blood sample for the clinical service evaluation successfully collected exclusion criteria: * withdrawn from clinical service evaluation of novel h1n1v vaccine * second blood sample for the clinical service evaluation not collected.

Keywords: swine flu novel h1n1v novel h1n1 h1n1
predictive value of tumor vascular normalization scoring in her-2 positive breast cancer

Conditions: HER2 Positive Breast Carcinoma; Neoadjuvant Therapy

Summary: this study aims to evaluate the predictive value of the tumor vascular normalization score for the efficacy of neoadjuvant therapy in her-2-positive breast cancer and explore its potential as a predictive biomarker. through longitudinal observation of her-2-positive breast cancer patients receiving standard treatment, we will analyze the correlation between vascular normalization scores and treatment responses (including objective response rate \[orr\] and pathological complete response \[pcr\]) to optimize individualized therapeutic strategies. additionally, an exploratory investigation will assess the impact of ginsenoside-containing formulations (e.g., jinxing capsule, shenyi capsule, yiqi jianpi oral liquid) on tumor vasculature and neoadjuvant therapy outcomes in her-2-positive breast cancer, providing scientific insights for complementary therapeutic interventions.


Eligibility criteria:
inclusion criteria: * female breast cancer patients aged ≥18 years planned for neoadjuvant therapy. * histopathologically confirmed her2-positive status (ihc 3+ or ihc 2+ with positive fish confirmation). * mentally competent, no psychiatric disorders, with good compliance to treatment and follow-up. * voluntarily participate and provide written informed consent. exclusion criteria: * her2-negative breast cancer. * pregnant, planning pregnancy, or lactating women. * history of allergic predisposition or known/suspected allergy to study drugs. * participation in other clinical trials within the past 4 weeks or planned enrollment. * other conditions deemed ineligible by the investigator.

Keywords: tumor vascular normalization score anti-her2 antibody treatment efficacy
pain score and opioid consumption of index and previous cesarean delivery

Conditions: Pain; Postoperative

Summary: postoperative pain after cesarean delivery is common and affects on both mothers and children. the goals of this retrospective observational study aim to predict pain score and opioid consumption of index cesarean delivery from pain score and opioid consumption of previous cesarean delivery.

the authors will review the medical records of recruited participants for demographic data as well as pain scores and opioid consumption of index cesarean delivery and previous cesarean delivery.

Eligibility criteria:
inclusion criteria: * patients who had at least 2 cesarean deliveries * patients received spinal anesthesia and intrathecal morphine for cesarean delivery * patients received postoperative pain control as per standard protocol exclusion criteria: * patients with chronic pain prior to cesarean delivery * unable to give pain score * receiving general anesthesia for cesarean delivery * receiving postoperative pain control beyond the standard protocol * patients with multiple pregnancy, placenta abruption, placenta accrete, postpartum hemorrhage * patients with psychotic disorder

Keywords: cesarean delivery opioid consumption pain score
drug biomarkers in cell samples from patients with acute myeloid leukemia

Conditions: Leukemia

Summary: rationale: studying cell samples from patients with cancer in the laboratory may help doctors learn more about changes that occur in dna and identify biomarkers related to cancer purpose: this research study is studying drug biomarkers in cell samples from patients with acute myeloid leukemia.

objectives: * to determine, in vitro, the cytotoxic activity of novel cd33-targeting immunoconjugate agents in cell samples from patients with acute myeloid leukemia (aml). * to define the characteristics of aml cells responding to or resisting these agents. outline: cell samples are thawed and used for in vitro studies to determine the cytotoxic activity of novel cd33-targeting immunoconjugate agents, including gemtuzumab ozogamicin, for genotyping characterization by flow cytometry-based assays and/or western blot, and colony-forming cell assays.

Eligibility criteria:
disease characteristics: * diagnosis of acute myeloid leukemia * cryopreserved samples available patient characteristics: * not specified prior concurrent therapy: * not specified

Keywords: adult acute myeloid leukemia with 11q23 (mll) abnormalities adult acute myeloid leukemia with del(5q) adult acute myeloid leukemia with inv(16)(p13;q22) adult acute myeloid leukemia with t(15;17)(q22;q12) adult acute myeloid leukemia with t(16;16)(p13;q22) adult acute myeloid leukemia with t(8;21)(q22;q22) childhood acute myeloid leukemia/other myeloid malignancies adult acute myeloid leukemia
change in tongue strength and fatigue after upper airway stimulation therapy

Conditions: Obstructive Sleep Apnea of Adult

Summary: upper airway stimulation (uas) is an effective surgical alternative for patients with obstructive sleep apnea (osa) who fail continuous positive airway pressure (cpap) therapy. this stimulation could lead to alterations in tongue strength and fatigability which could alter treatment outcome. the aim of the study is to investigate if uas alters tongue strength and fatigability.


Eligibility criteria:
inclusion criteria: * 18 years old or older * upper airway stimulation group: upper airway stimulation system implanted at least 4 weeks ago * osa group: osa confirmed by 18-channel inpatient overnight polysomnography (psg) * test group: no medical history for osa and epworth sleepiness scale (ess) below 11 exclusion criteria: * history of a neuromuscular disorder * previous tongue surgery
movicol in childhood constipation (promotion study)

Conditions: Feces, Impacted

Summary: this was a single centre study comprised of two stages (parts i and ii). part i was a 9-day open label evaluation of movicol administered to patients in hospital. this study evaluated the safety and efficacy of movicol in treating faecal impaction. movicol was administered over 3 - 7 days to achieve disimpaction.

patients received movicol treatment until disimpaction was achieved according to the following regime: day 1: ages 2 - 4 received 1 (one) sachet whilst 5 - 11 year olds received 2 (two). day 2: ages 2 - 4 received 2 (two) sachets whilst 5 - 11 year olds received 3 (three). day 3: ages 2 - 4 received 2 (two) sachets whilst 5 - 11 year olds received 4 (four). day 4: ages 2 - 4 received 3 \*three) sachets whilst 5 - 11 year olds received 5 (five). day 5: ages 2 - 4 received 3 (three) sachets whilst 5 - 11 year olds received 6 (six). day 6: ages 2 - 4 received 4 (four) sachets whilst 5 - 11 year olds received 6 (six). day 7: ages 2 - 4 received 4 (four) sachets whilst 5 - 11 year olds received 6 (six). if on day 8 the patient was still impacted they were withdrawn from study and treated according to their individual needs. disimpaction was assessed clinically (loss of faecal masses and passage of watery stools). two days following disimpaction patients were randomised (according to the randomisation list) to receive movicol or lactulose dry. during bowel retraining the appropriate maintenance dose of movicol or lactulose dry was determined. patients were discharged once they were passing regular, painless, bowel actions.

Eligibility criteria:
inclusion criteria: * patients that, in the opinion of the investigator, are constipated/fecally impacted as to require hospital stay to treat and/or relieve the impaction * children aged 2 - 11 years old inclusive * patients of either sex exclusion criteria: patients with * intestinal perforation or obstruction * severe inflammatory conditions of the intestinal tract * uncontrolled renal/hepatic/cardiac diseases * uncontrolled endocrine disorder(s) * any neuromuscular condition affecting bowel function * hypersensitivity to lactulose or peg or other constituent of movicol * patients who have taken any investigational drug in the three months * patients or patients whose parents would in the opinion of the investigator are unable to comply with requirements of the study
exercise in gulf war illness (gwi)

Conditions: Gulf War Illness; Persian Gulf Syndrome

Summary: the purpose of this study is to determine if submaximal exercise by bicycle stress tests with pulmonary measurement of vo2max plus maximal isometric hand grips on 2 consecutive days causes a higher level of "exertional exhaustion" in gwi compared to healthy veterans (hvets).

subjects sat on upright bicycles for preexercise symptoms, respiratory gases, ekg, and vital sign measurements. submaximal exercise began at low resistance with increases every 30 to 60 seconds until 70% predicted heart rate was reached by 5 minutes. subjects maintained their pace until 25 minutes, then resistance was increased incrementally to increase to 85% predicted heart rate (approximately sufficient to reach anaerobic threshold). symptoms, respiratory gases, ekg, and vital signs were measured every 5 minutes, at peak of exercise, and 5 minute intervals after exercise. the identical exercise protocol was used approximately 24 hr later. secondary outcomes were assessed by comparisons from before exercise to after the second bicycle exercise stress test.

Eligibility criteria:
inclusion criteria: * evidence of military enlistment between august 1, 1990 and july 31, 1991, and deployment for 30 consecutive days to: * persian gulf waters and adjacent land areas * other global locations * u.s. only * status prior to 1990 and 1991: * active duty * national guard * reserves exclusion criteria: * current active duty military personnel * any one who was not active duty military personnel between august 1, 1990 and july 31, 1991 * hiv/aids; pregnancy or lactation; potential hepatitis; drug addiction; chronic inflammatory, infectious, or autoimmune medical illnesses not associated with gwi; incarceration; dementia, other cognitive limitation; or reliance on a care-giver in order to respond to the questionnaires and other study tests. amputations of one or both hands and forearms will be permitted but hand grip tests will not be tested

Keywords: persian gulf war gulf war syndrome gwi gulf war illness exercise chronic fatigue fibromyalgia veterans irritable bowel syndrome migraine headaches neuropathy
respiratory muscle endurance in obesity hypoventilation syndrome

Conditions: Obesity Hypoventilation Syndrome (OHS)

Summary: obesity hypoventilation syndrome (ohs) is defined as a combination of obesity \[body mass index (bmi) ≥30 kg/m2\], chronic daytime hypercapnia (paco2 \>45 mm hg), and sleep-apnea in the absence of other known causes of hypercapnia. respiratory system compliance decreases and resistance increases in ohs. this causes increase in work of breathing and oxygen cost of breathing, which may result in respiratory muscle fatigue. increase in respiratory workload and increase in resistance to respiration is expected to decrease in respiratory muscle endurance (rme) in subjects with ohs.

in the literature, studies evaluating rme in subjects with ohs are limited. no study has been found to evaluate rme using the incremental load test in subjects with ohs. accordingly, it was aimed to evaluate and compare respiratory muscle endurance in subjects with ohs and a control group, and to determine factors associated with respiratory muscle endurance.

Eligibility criteria:
inclusion criteria: * diagnosed with ohs * obese subjects (30 \< body mass index \< 40 kg/m2) with low risk of obstructive sleep apnea (stop-bang score \< 3) exclusion criteria: * severe respiratory disease * subjects with orthopeadic and/or neurologic disorders that could limit exercise tests

Keywords: respiratory muscle endurance sleep fatigue quality of life
lung ultrasound to diagnose transient tachypnea of the newborn (ttn) versus respiratory distress syndrome (rds) in neonates

Conditions: Transient Tachypnea of the Newborn; TTN; Respiratory Distress Syndrome; RDS

Summary: the investigators hypothesize that ultrasonography of the newborn lung can be used as an effective diagnostic tool in neonates ≥ 28 weeks gestation with early symptoms of respiratory distress.

respiratory distress is a common reason for admission to the neonatal intensive care unit (nicu) for both preterm and full term newborns. ttn and rds are the two most common diagnoses associated with respiratory distress. due to their similar clinical presentations, it is often difficult to differentiate the two diseases clinically. currently chest radiography is used to differentiate between ttn and rds, however, radiographic findings are not always definitively diagnostic. in preliminary studies, lung ultrasonography has been shown to be a useful tool in diagnosing both ttn and rds. however, no one has looked at the use of lung ultrasonography in differentiating ttn from rds in the neonatal population. we propose to do so in this study. patients will be enrolled from neonatal admissions to the nicu with respiratory distress. lung ultrasound will be performed on all enrolled subjects, looking for specific findings suggestive of either ttn or rds. data will be collected on gestational age, physical exam findings and level of respiratory support. diagnoses will be recorded based on ultrasound findings. accuracy of lung ultrasound diagnosis will be compared to that using radiographic chest radiography findings to evaluate if lung ultrasound is equivalent, or better than chest radiography in order to diagnose ttn versus rds in this patient population.

Eligibility criteria:
inclusion criteria: * gestational age ≥ 28 weeks * symptoms of respiratory distress defined as: * tachypnea (respiratory rate \> 60 breaths per minute) * fio2 requirement \>21% * intercostal/subcostal retractions * grunting and/or nasal flaring * if clinically warranted, a chest x-ray will be done as part of the workup for respiratory distress; these patients with cxr will be included in the study. * inclusion criteria for the control group will be gestational age ≥ 28 weeks with no symptoms of respiratory distress (defined above). exclusion criteria: * neonates with prenatally diagnosed structural cardiac disease * major multiple congenital anomalies * other causes of respiratory distress that are not rds or ttn (e.g. pneumothorax, ccam or pneumonia).

Keywords: transient tachypnea of the newborn respiratory distress syndrome lung ultrasound neonates
mobilization with movement versus joint-specific manipulation in de quervain's tenosynovitis

Conditions: Tenosynovitis

Summary: a comparative study on the effectiveness of mobilization with movement (mwm) versus joint-specific manipulation (jsm) in patients with de quervain's tenosynovitis typically aims to assess how each technique impacts pain relief and functional improvement. de quervain's tenosynovitis is an inflammation of the tendons around the thumb and wrist, often causing pain, swelling, and difficulty in performing everyday tasks. the study would likely compare the two interventions by measuring pain levels, range of motion, and overall functional outcomes before and after treatment. mwm involves applying specific, controlled movements while the patient is actively engaging in their joint motion, targeting the tissue's mobility and reducing pain. jsm, on the other hand, focuses on manipulating the joint directly to restore normal function, specifically targeting the wrist and thumb regions affected by the condition.

a comparative study on the effectiveness of mobilization with movement (mwm) versus joint-specific manipulation (jsm) in patients with de quervain's tenosynovitis would delve deeper into the physiological mechanisms and clinical outcomes associated with each technique, providing valuable evidence for therapeutic decision-making. de quervain's tenosynovitis is a condition characterized by the inflammation of the tendons at the base of the thumb, particularly affecting the abductor pollicis longus and extensor pollicis brevis tendons. this condition is commonly caused by repetitive strain, overuse, or trauma, leading to pain, swelling, and restricted movement, which significantly impacts the patient's daily activities.

Eligibility criteria:
inclusion criteria:o patients clinically diagnosed with de quervain's tenosynovitis * age between 25-45 years. * positive finkelstein test. * pain over the first dorsal compartment. * limited wrist and thumb function. * willingness to take part and adhere to the study's guidelines. exclusion criteria:participants fall in this category would be excluded of the study. * previous surgery of wrist or thumb. * presence of neurological symptoms like numbness, weakeness. * rheumatological conditions like rheumatoid arthritis. * pregnancy. * presence of wrist fracture or osteoporosis. * carpel tunnel syndrome.

Keywords: tenosynovitis