Kornimate/medical-research-clean huggingface dataset:
casting versus flexible intramedullary nailing in displaced pediatric forearm shaft fractures

Conditions: Both Bone Forearm Fracture; AO Classification 22D/2.1-5.2; 7-12 Year Old

Summary: the forearm is the most common fracture location in children, with an increasing incidence. displaced forearm shaft fractures have traditionally been treated with closed reduction and cast immobilization. diaphyseal fractures in children have poor remodeling capacity, and malunion can thus cause permanent cosmetic and functional disability. internal fixation especially with flexible intramedullary nails has gained increasing popularity, without evidence of a better outcome compared to closed reduction and cast immobilization.

this is a multicenter, randomized superiority trial comparing closed reduction and cast immobilization to flexible intramedullary nails in 7-12 year old children with \> 10° of angulation and/or \> 10mm of shortening in displaced both bone forearm shaft fractures (ao-pediatric classification: 22d/2.1-5.2). a total of 78 patients with minimum 2 years of expected growth left are randomized in 1:1 ratio to either treatment group. the study has a parallel non-randomized patient preference arm. both treatments are performed under general anesthesia. in the cast group a long arm cast is applied for 6 weeks. the flexible intramedullary nail group is immobilized in a collar and cuff sling for 4 weeks. data is collected at baseline and at each follow-up until 1 year. primary outcome is 1) promis pediatric item bank v2.0 - upper extremity and 2) forearm pronation-supination range of motion at one-year follow-up. secondary outcomes are quick dash, pediatric pain questionnaire, cosmetic vas, wrist range of motion as well as any complications (malunion, delayed union, non-union or deep wound infection, peripheral nerve injury, need for re-intervention during 1-year follow-up) and costs of treatment. the investigators hypothesize that flexible intramedullary nailing results in a superior outcome.

Eligibility criteria:
inclusion criteria: * 7 to12 year old children * open distal radial physis * both bone forearm shaft fractures (ao-pediatric classification: 22d/2.1-5.2) * more than 10 degrees of angulation * with or without less than 10mm of shortening exclusion criteria: * patients with bilateral fractures * gustilo-anderson grade i-iii open fracture * neurovascular deficit * compartment syndrome * pathologic fracture * patient not able to give a written informed consent
stapled vs hand sewn anastomosis in roux en y gastric bypass for morbid obesity: randomized clinical trial

Conditions: Morbid Obesity

Summary: the purpose of this study is to compare postoperative complications between hand sewn and stapled anastomosis after performing roux en y-gastric bypass as a treatment for morbid obesity.


Eligibility criteria:
inclusion criteria: * patients over 18 years * absence of previous bariatric surgery exclusion criteria: * less than 18 years old * coagulation disorders or liver cirrhosis

Keywords: roux en y gastric bypass postoperative complications hand sewn anastomosis stapled anastomosis
this study will investigate the safety, tolerability, pharmacokinetics, and efficacy of met097 in adult participants with overweight or obesity

Conditions: Obesity and Overweight

Summary: the goal of this phase 1/2 clinical trial is to assess the safety, tolerability, pharmacokinetics, and efficacy of once-weekly subcutaneous injections of met097 in otherwise healthy adults with overweight or obesity. the trial will be conducted in three parts. part a consists of single ascending dose (sad) cohorts of met097 or placebo. part b consists of multiple ascending dose (mad) cohorts, with participants treated with five once-weekly doses of met097 or placebo. in part c, participants will receive once-weekly doses of met097 or placebo for 12 weeks, followed by a single dose at 2x or 4x to explore the potential for once-monthly dosing.


Eligibility criteria:
inclusion criteria: * overweight/obese but otherwise healthy adult male or female with a bmi within 27.0 kg/m2 to 38.0 kg/m2, inclusively * at least 18 years of age but not older than 70 years of age * have no clinically significant diseases captured in the medical history or evidence of clinically significant findings on the physical examination (including vital signs) and/or ecg, as determined by an investigator * estimated glomerular filtration rate (egfr) ≥90 ml/min at the screening visit exclusion criteria: * female who is lactating or who is pregnant according to the pregnancy test at the screening visit or prior to the first study drug administration * seated blood pressure higher than 160/95 mmhg at the screening visit * elevated resting pulse greater than 100 beats per minute at screening visit * presence of clinically significant ecg abnormalities * diagnosis of diabetes (type 1 or type 2) * participation in a weight loss program with or without pharmacotherapy during the 3 months prior to study administration * obesity induced by endocrinologic disorders (e.g., cushing's syndrome) or diagnosed monogenetic or syndromic forms of obesity (e.g., melanocortin 4 receptor deficiency or prader-willi syndrome). * personal or family history of medullary thyroid cancer or multiple endocrine neoplasia type
pathology of helicases and premature aging: study by derivation of hips

Conditions: Age Problem

Summary: topic of this work is the involvement of replicative helicases in human premature ageing syndrome. replicative helicases are ubiquitous and essential during numerous reactions of the dna metabolism. the family of replicative helicases (recql) is involved in the replication/repair of the dna and in the telomere maintenance. there are 5 enzymes in human and 3 of them are involved in clinically recognizable syndromes: wrn for the werner syndrome, blm for the bloom syndrome and recql4 for the rothmund thomson syndrome. all are responsive of a high cancer risk due to genomic instability. molecular and cellular mechanisms involved in these diseases of ageing are unknown. moreover, for all of them, there is not therapeutic or preventive solution.

for understanding the involved mechanisms we would like to model the 3 diseases with hips (human induced pluripotent stem cells) from somatic cells of patients. the patient recruitment was organized by the montpellier and nîmes public hospitals. the project is to generate a hips cell line for the 3 syndromes from fibroblasts and/or blood samples. then, we could induce differentiation of hips to a target cell line of the diseases. finally we could study the disease development following the genomic instability (karyotype, array-cgh) and the cellular ageing (senescence-associated heterochromatin foci, telomere length). for each mutated enzyme, we will perform a transcriptional profiling (splice, mrna quantification) and protein studies (western blot). all results will be compared to wild type cells.

Eligibility criteria:
inclusion criteria: * patinet with one of the 3 helicase-associated precoce aging desease exclusion criteria: * minor and /or mentally incapable patient

Keywords: helicase induced pluripotent stem cells
combination dexamethasone and bupivacaine pain control in reduction mammaplasty

Conditions: Pain, Postoperative; Mammaplasty

Summary: the addition of dexamethasone to non-liposomal bupivacaine in perineural blocks has been shown to enhance pain control and prolong the time until first request for postoperative narcotics in the fields of orthopedic, thoracic, and gynecologic surgery. this has not been investigated in any types of breast surgery. the investigators assessed if the combination of dexamethasone to bupivacaine in the preoperative field block prior to bilateral breast reduction surgery resulted in improved pain control relative to bupivacaine alone.

the investigators conducted a double-blind randomized controlled trial to determine whether the addition of dexamethasone to bupivacaine in a preoperative pecs ii block resulted in improved pain control, relative to bupivacaine alone, in patients undergoing bilateral reduction mammaplasty. using a preassigned randomization list, patients were randomized to experimental and control groups in a ratio of 1:1 upon enrollment. both groups received pecs ii bupivacaine field blocks in the preoperative holding area, performed by an acute pain fellowship-trained anesthesiologist. the experimental group received 29ml of 0.5% bupivacaine mixed with 1ml 4mg/ml dexamethasone per side. the control group received 29ml 0.5% bupivacaine mixed with 1ml 0.9 saline solution per side. to maintain the blinded aspect of the study, the anesthesiologists were given pre-mixed vials labelled uniformly for the trial, regardless of the patient's treatment arm. the patients all underwent bilateral breast reduction with a single surgeon. postoperative pain regimens were standardized. subjective pain scores, narcotic consumption, 4-hour interval vital signs, anti-emetic usage, and postoperative quality of life via an sf-36 questionnaire were all recorded per patient.

Eligibility criteria:
inclusion criteria: * female * age 18-80 * bilateral reduction mammaplasty * american society of anesthesiologists (asa) physical status classification 1, 2, or 3 * must choose to receive preoperative nerve block as part of pain management strategy exclusion criteria: * allergy to dexamethasone or bupivacaine * history of postoperative nausea and vomiting following anesthesia * history of chronic pain conditions * history of narcotic abuse or dependency * history of chronic renal disease * history of chronic liver disease
a randomized controlled pilot trial comparing irish set dancing to usual care for people with parkinson's disease

Conditions: Parkinson's Disease

Summary: primary aim is to conduct a pilot trial to determine: 1. the feasibility and efficiency of randomisation procedures and study design 2. if recruitment rates are sufficient to adequately power a larger trial the secondary aim is to determine the efficiency of set dancing in comparison to a control for people with patkinson's disease.


Eligibility criteria:
inclusion criteria: * have a diagnosis of idiopathic parkinson's disease (hackney et al 2007; marchant et al 2010), stage 1-2.5 on the modified hoeln and yahr scale for staging of parkinson's disease (batson 2010) * able to walk three meters with an assistive device * over 18 years of age * not pregnant * have access to a computer/dvd player to allow them to participate in the home exercise programme exclusion criteria: * a serious cardiovascular and/or pulmonary condition (lodder et al 2004) * a neurological deficit other than parkinson's disease (batson 2010; marchant et al 2010) * evidence of a musculoskeletal problem (duncan and earhart 2012), contraindicating participation in exercise participation(lodder et al 2004) * a cognitive or hearing problem which will affect their ability to follow instructions or hear the music (batson 2010) * participated in regular dance classes in the past six months (marchant et al 2010)

Keywords: parkinson's disease irish set dancing
the effect of an app-based intervention on quality of life in patients with endometriosis.

Conditions: Endometriosis; Pain; Quality of Life; Life Style

Summary: the goal of this clinical trial is to learn if an app-based intervention affects the quality of life in patients with suspected or confirmed endometriosis. the main questions it aims to answer are: * does the app-based intervention improve the quality of life? * does it lead to pain relief? researchers will compare participants using the app to a control group to see if the app works to improve quality of life and endometriosis-related symptoms. participants will: * use an app-based intervention or be in the control group (no app-use) for 6 months * visit or have a telephone consultation after 3 and 6 months * complete a questionnaire to assess the quality of life at inclusion, after 1, 3 and 6 months


Eligibility criteria:
inclusion criteria: * informed consent as documented by signature * age 18 or older * premenopausal status (menopause is defined as amenorrhea lasting one year or longer) * endometriosis, confirmed by surgery or clinically suspected * possession of a smartphone exclusion criteria: * planned endometriosis surgery or planned hormonal therapy in the study period * surgery and/or new hormonal therapy in the last three months * malignant diseases * pregnancy * breastfeeding * active desire for pregnancy in the study period * fertility treatment * simultaneous participation in other intervention studies
obstetric and proctology support of patients with perineums suits

Conditions: Obstetric Complications; Muscle Tear

Summary: perineal tear grade iii and iv are relatively common (1-10% of deliveries depending on the series), and are a source of potentially serious complications, even long time after delivery (especially disorders of anal continence, psychological trauma). if a number of risk factors are well described, the support arrangements at the time of delivery and the characteristics of the review proctological remote delivery and its relationship to the clinical status of patients is little known and rarely studied. in maternity wards of the hospital saint joseph paris and cochin-port royal group, patients with a diagnosis of severe perineal tear was made are taken following load with common rules, both for the immediate repair for the remote monitoring. patients of both sites are indeed encouraged to consult in proctology consultation in saint joseph 4-6 months of birth. the same support on both sites allows to consider the creation of a relatively homogeneous cohort in terms of support and consider an important recruitment. moreover, the geographical proximity of the inclusions sites (maternity) with proctology service is likely to limit the risk of lost sight of.

main objective / secondary: describe exactly the operational management of severe perineal tear (grade iii and iv), their context and the factors associated with them occurring, the results of clinical and paraclinical proctology examination carried away from the birth, and study their relationship with the clinical status of patients at 6 months, 1, 2 and 3 years of confinement. methodology : type prospective, multicentre, non-interventional study duration: 6 years

Eligibility criteria:
inclusion criteria: * all patients over 18 years * affiliated to the national system of social security, * giving birth during the period of inclusion of the st. joseph site or port royal for whom the diagnosis of severe perineal tear was done. exclusion criteria: * none
a comparative clinical study to determine the optimal initial therapy for multiple myeloma

Conditions: Multiple Myeloma

Summary: this study evaluates the outcomes of patients undergoing initial therapy for multiple myeloma.

primary objective: i. compare the overall survival between bortezomib, lenalidomide and dexamethasone (vrd), daratumumab, lenalidomide and dexamethasone (drd) and daratumumab, bortezomib, lenalidomide and dexamethasone (dvrd) used as initial therapy for patients with newly diagnosed mm. outline: this is an observational study. patients have their medical records reviewed on study.

Eligibility criteria:
inclusion criteria: * previously untreated active multiple myeloma starting a new treatment for the disease with one of the three established treatment regimens: vrd (bortezomib, lenalidomide, dexamethasone), drd (daratumumab lenalidomide dexamethasone), or dvrd (daratumumab, bortezomib, lenalidomide, and dexamethasone) * no prior treatment for myeloma * not receiving concurrent treatment for another active malignancy * no more than 3 months from start of treatment exclusion criteria: * does not meet all inclusion criteria
burnout, covid 19, smarthphone addiction

Conditions: Burn Out; Addiction, Smartphone

Summary: we investigate burnout syndrome and smartphone addiction in healthcare workers, including doctors, nurses, medical secretaries, security guards, and cleaning staff, who have been actively working from the beginning of the covid-19 pandemic. target population included 1190 healthcare workers, from which a total of 183 agreed to participate in the study and met the inclusion criteria for participation. a sociodemographic data form, the maslach burnout inventory, and the smartphone addiction scale-short version were used as the data collection tools.

significant differences in burnout syndrome were found in doctors and nurses. a relationship was observed between emotional burnout (eb), desensitization, and smartphone addiction, as well as between doctor and nurse group, and smartphone addiction. according to the linear regression analysis, it was determined that 17% of the change in the smartphone addiction score was related to age and 16% to master education level.doctors and nurses experience the highest rate of burnout syndrome and smartphone addiction, and eb and desensitization were more likely to have smartphone addiction. age and high education can affect smarthphone addiction

Eligibility criteria:
inclusion criteria: 1. being older than 18 years of age 2. working as medical staff 3. having no systemic or psychiatric disorders 4. no psychotropic substances use 5. no alcohol or substance use exclusion criteria: -

Keywords: burnout covid-19 healthcare workers smarthphone addiction
comparison of therapeutic effects of greater occipital nerve block, topiramate, and flunarizine on episodic migraine

Conditions: Migraine

Summary: background: preventive drug therapy in migraine aims to reduce the attack frequency, severity and duration of headache. flunarizine and topiramate are widely used in the prevention of migraine attacks. greater occipital nerve block (gonb) is an alternative treatment option for the prophylactic treatment of migraine. in this study, investigators compared the effectiveness of gonb, topiramate, and flunarizine in terms of reduction in post-treatment vas scores and attack frequencies in patients with episodic migraine in a four-week period. material and methods: at least one hundred and twenty migraine patients are aimed to be randomly divided into three treatment groups, namely flunarizine (n=40, estimated), topiramate (n=40, estimated) and gonb (n=40, estimated). the patients will be followed up for four weeks and the attack frequencies and vas scores will be recorded weekly. at the end of the fourth week, the response rates based on 50% and 75% or more reduction in the vas scores and attack frequencies will be calculated. group-wise comparisons will be assessed statistically.


Eligibility criteria:
inclusion criteria: 1. migraine diagnosis according to ichd-2 2. ages between 15 -45 volunteering 3. monthly attack number between 5-14 4. bmi between 18-30 5. w/o history of nephrolithiasis 6. w/o history of dm, peripheral vascular disease 7. w/o history of chronic systemic diseases (lung, heart,liver, kidney) 8. w/o any detected cns disease (including ms, movement disorders, cvd, primary or secondary tumors) 9. w/o history of acute or chronic psychiatric disease 10. w/o history of antiplatelet and anticoagulant medication 11. w/o any combination of medication overuse headache or other primary headaches 12. w/o previous medication of flunarizine and topiramate 13. w/o previous application of gonb exclusion criteria: 1. pregnancy 2. lost to follow up * exited with his/her own will * detected primary headache during follow up * cessation due to adverse effects of topiramate * cessation due to adverse effects of flunarizine

Keywords: migraine greater occipital nerve block topiramate flunarizine
interscalene block versus combined infraclavicular-anterior suprascapular blocks for shoulder surgery

Conditions: Pain, Postoperative; Shoulder Pain; Surgical Procedure, Unspecified; Diaphragmatic Paralysis

Summary: postoperative analgesia after shoulder surgery remains a challenge in patients with preexisting pulmonary pathology, as interscalene brachial plexus block (isb), the standard nerve block for shoulder surgery, carries a prohibitive risk of hemidiaphragmatic paralysis (hdp). although several diaphragm-sparing nerve blocks have been proposed, none seems to offer equivalent analgesia to isb while avoiding hdp altogether. for instance, even costoclavicular blocks, which initially fulfilled both requirements, were subsequently found to result in a non-negligible 5%-incidence of hdp. in this randomized trial, the authors set out to compare isb and combined infraclavicular block-anterior suprascapular nerve blocks (icb-assnb) for patients undergoing arthroscopic shoulder surgery. the authors hypothesized that icb-assnb would provide equivalent postoperative analgesia to isb 30 minutes after shoulder surgery and therefore designed the current study as an equivalence trial.


Eligibility criteria:
inclusion criteria: * patients undergoing arthroscopic shoulder surgery * american society of anesthesiologists classification 1-3 * body mass index between 20 and 35 kg/mt2 exclusion criteria: * adults who are unable to give their own consent * pre-existing neuropathy (assessed by history and physical examination) * coagulopathy (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. platelets ≤ 100, international normalized ratio ≥ 1.4 or prothrombin time ≥ 50) * obstructive or restrictive pulmonary disease (assessed by history and physical examination) * renal failure (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. creatinine ≥ 100) * hepatic failure (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. transaminases ≥ 100) * allergy to local anesthetics (las) * pregnancy * prior surgery in the neck or infraclavicular region * chronic pain syndromes requiring opioid intake at home

Keywords: postoperative shoulder analgesia diaphragmatic paralysis alternative blocks
the effect of music on quality of life in fibromyalgia patients

Conditions: Fibromyalgia; Music Therapy; Quality of Life

Summary: this study's aim was to determine the effect of music therapy on symptoms and functions in patients with fibromyalgia syndrome (fms).

this study's aim was to determine the effect of music therapy on symptoms and functions in patients with fibromyalgia syndrome (fms). women diagnosed with fms for at least 6 months included in the study. 16 patients were in the music treatment group and 51 patients were in the control group. patients in music treatment group were given a music cd which includes nature sounds recommended by the turkish psychological association. the patients were evaluated with fibromyalgia impact questionnaire (fiq) before and after the treatment.

Eligibility criteria:
inclusion criteria: * female patients over the age of 18 * being diagnosed as fms according to 2010 american college of rheumatology (acr) criteria for fms * having the diagnosis of fms at least six months exclusion criteria: * patients with hearing problems, pregnancy, another accompanying central sensitization syndrome or schizophrenia * patients with psychiatric illness * patients whose pharmacological treatment for fms changed within the last three months * patients without a listening device * patients who do not have a cognitive level to answer the questions in the scale

Keywords: fibromyalgia music therapy fibromyalgia impact questionnaire