Kornimate/medical-research-clean huggingface dataset:
evaluation of the acute effect of water-pipe smoking on the respiratory system

Conditions: Carboxyhemoglobin; Vital Signs; Fractional Exhaled NO; Exhaled Breath Condensate

Summary: title: the acute effect of water pipe smoking on exhaled nitric oxide (eno) and exhaled breath condensate (ebc) pulmonary function tests in healthy volunteers objectives: to evaluate the acute effect of one cession of water pipe smoking on airway inflammation as assessed by exhaled nitric oxide (eno) and exhaled breath condensate (ebc) in healthy volunteers. design: prospective study evaluating these parameters before and after 30 minutes of water pipe smoking . the changes in inflammatory parameters pre and post smoking will be evaluated blindly. sample size: 100 participants participant selection: adults subjects who regularly smoke water pipe . intervention: each subject will undergo evaluation including a respiratory questionnaire , pulmonary function tests , exhaled nitric oxide (eno) and exhaled breath condensate (ebc) and carboxy- hemoglobin levels . all measurements will be evaluated before and after one cession of 30 minutes water pipe smoking primary outcome parameter: change in carboxy- hemoglobin secondary outcome parameter:change in peripheral eosinophils count, pulmonary function tests, change in feno, and in inflammatory parameters in ebc before and after water pipe smoking


Eligibility criteria:
inclusion criteria: * age \> 18 y.o. * have smoked water-pipe at least once before. exclusion criteria: * breast feeding women. * s/p bacterial or viral infection, last 2 weeks * p.o. steroids * water-pipe smoking, last 24 hours * cigarette smoking, last 6 hours * intensive exposure to smoke (fire), last 24 hours * s/p intensive care hospitalization, last 3 months

Keywords: water pipe smoking acute effect
a study of combination treatment with mabthera (rituximab) and roactemra (tocilizumab) versus roactemra in patients with rheumatoid arthritis with an incomplete response to methotrexate

Conditions: Rheumatoid Arthritis

Summary: this 2 part study will investigate the safety, tolerability and efficacy of mabt hera in combination with roactemra in patients with active rheumatoid arthritis despite a stable dose of methotrexate. in part 1 of the study, patients will be randomized to receive either mabthera 0.5g iv or placebo on days 1 and 15, follo wed by roactemra at one of the ascending doses between 2mg/kg and 8mg/kg at week s 4, 8 and 12 (mabthera arm) or 8mg/kg (placebo arm). in part 2, additional pati ents will be randomized to one of 2 groups to receive mabthera 0.5g on days 1 an d 15 followed by the selected dose (from part 1)of roactemra at weeks 4, 8 and 1 2, or placebo on days 1 and 15 followed by roactemra 8mg/kg at weeks 4,8 and 12. all patients will then be eligible to receive extension treatment withroactemra every 4 weeks. the anticipated time on study treatment is 12 months, and the tar get sample size is \<100 individuals.


Eligibility criteria:
inclusion criteria: * adult patients, 18-65 years of age; * rheumatoid arthritis, functional status i-iii; * sjc\>=4 (28 joint count) and tjc\>=4 (28 joint count) at screening and baseline; * rf and/or anti-ccp positive; * may have failed up to 1 approved anti-tnf agent (infliximab, etanercept or adalimumab); * inadequate response to methotrexate, at a dose of 7.5-25mg weekly for at least 12 weeks, at a stable dose for past 4 weeks. exclusion criteria: * rheumatic autoimmune disease other than rheumatoid arthritis, or significant systemic involvement secondary to rheumatoid arthritis; * history of, or current, inflammatory joint disease other than rheumatoid arthritis; * diagnosis of juvenile idiopathic arthritis and/or rheumatoid arthritis before age 16; * significant cardiac or pulmonary disease; * previous treatment with any biologic agent for rheumatoid arthritis (other than infliximab, etanercept or adalimumab).
radiation-free bone imaging ute mri in healthy and diseased patients

Conditions: Bone Anatomy; Bone Diseases

Summary: in summary, the investigators want to investigate whether ute sequences are capable to replace imaging techniques involving ionizing radiation for bone imaging in the future. this would improve patient care greatly and might reduce medical imaging associated cancer risk drastically from an epidemiological standpoint. this field of research can be considered cutting-edge. the investigators determine this study promising to provide substantial generalizable knowledge and hope that this study results will improve patient care worldwide considerably.

to date, definite depiction of anatomy or pathologies of bony structures requires ionizing radiation by using radiographs or computed tomography (ct) since conventional magnetic resonance imaging (mri) that does not require ionizing radiation cannot depict bony structures well. modern mr techniques, collectively referred to as ultrashort time to echo (ute) sequences, have overcome this issue by acquiring the signal data much faster and therefore are able to acquire sufficient mr signal from bony structures. the investigators want to investigate if ute sequences are capable to depict bony anatomy and pathology similar to imaging examination techniques involving ionizing radiation. healthy adult and minor participants, as well as adult and minor participants, referred for a clinically indicated mri involving the skeletal system will be included.

Eligibility criteria:
inclusion criteria: * adults and minors (all ages) capable of giving informed consent or have a legal representative capable of giving consent on the participant's behalf. informed consent as documented by signature (appendix informed consent form) * for participants referred for a clinical indicated mri (primary objective) inclusion criterion is the presence of radiographs or a ct scan of the part of the skeletal system that is under investigation within the clinical indicated mri * for healthy volunteers (secondary objective) any volunteer that is not referred for a clinical indicated mri scan exclusion criteria: * women who are pregnant * general known contraindications for mri (e.g., non-mr compatible pacemaker) * homeless persons, or persons with active drug/alcohol dependence or abuse history

Keywords: bone imaging; mri; ute; radiation-free; ultrashort echo time ; anatomy
extensive circumferential partial thickness sclerectomy in nanophthalmic eyes

Conditions: Nanophthalmos

Summary: purpose: to describe an extensive scleral excision technique to treat or prevent uveal effusion in nanophthalmic eyes. design: prospective interventional case series. methods: * setting: institutional. * patient population: consecutive patients with nanophthalmos were operated on by one surgeon. * intervention procedure: a single, 90% thickness scleral window extending from immediately behind the extraocular muscle insertions to the vortex veins was performed for 3 and 1/4 quadrants as a circumferential strip. * main outcome measure: resolution or prevention of uveal effusion.

surgical technique all surgeries were performed under general anesthesia by one surgeon (amm). because the majority of the patients were young with narrow palpebral fissures and very deep set globes in small orbits, special surgical techniques were required. lateral canthotomy was performed on all patients except for the first. limbal 360o conjunctival peritomy was followed by securing of each rectus muscles with a modified muscle hook and 2-0 silk suture. scleral dissection was performed from immediately behind to the muscle insertions posterior to the vortex veins. a 90% depth scleral window was excised over 3 and ¼ quadrants, excluding 3/4 of the superior temporal quadrant to avoid damaging the superior oblique muscle.

Eligibility criteria:
inclusion criteria: nanophthalmos - exclusion criteria: none -

Keywords: uveal effusion
evaluation of serum interleukin-15 and interleukin-22 levels in patients with non-segmental vitiligo

Conditions: Vitiligo

Summary: evaluation of serum interleukin-15 and interleukin-22 levels in patients with non-segmental vitiligo before and after phototherapy

this prospective study will include 30 patients with nsv, attending the outpatient clinics of dermatology at sohag university hospitals, as well as 30 normal volunteers as control. this study will be submitted for approval by research and ethical committees at sohag faculty of medicine. an informed written consent will be obtained from each subject prior to participation in the study after full explanation of the procedure.

Eligibility criteria:
inclusion criteria: * • patients suffering from non segmental vitiligo. * patients not on medical treatment or phototherapy for vitiligo in the last 3 months. exclusion criteria: * • patients with systemic or cutaneous inflammatory disorders. * patients on treatment for vitiligo in last 3 months. * pregnant and lactating patients. * patients with history of diabetes. * patients with history of autoimmune diseases.
brain excitability and connectivity in sensory-motor pathways in als

Conditions: Amyotrophic Lateral Sclerosis

Summary: the main objective is to determine the origin of somatosensory alteration in patients with als and to evaluate its impact on brain activity by coupling different imaging modalities and indirect electrophysiology. the secondary objective is to evaluate whether the observed functional changes in meg / eeg and functional mri correlate with structural lesions revealed with diffusion mri (anatomo-functional connectivity of the brain).

somatosensory evoked potentials (seps) produced by ulnar nerve electrical stimulation will be collected with combined meg and egg. functional mri will be performed during electrical stimulation of ulnar nerve and during mechanical vibration of adm tendon. brain diffusion mri will be performed. anatomical mri will be done for source location. brain resting state activity will be recorded with meg/eeg and fmri.

Eligibility criteria:
inclusion criteria: * als, mrc score ≥ 4 at least in one hand * controls: no history of neurological disorders, right-handed exclusion criteria: * contraindication to mri

Keywords: brain excitability brain connectivity motor cortex somatosensory cortex
staphylococcus aureus surgical site infection multinational epidemiology in europe

Conditions: Staphylococcus Aureus; Wound Infection, Surgical; Epidemiology

Summary: this is a retrospective multinational, multicenter cohort study with a nested case-control. the study includes all surgical procedures performed at a participating site to prevent bias. data will be assessed in two populations. cohort population: export of electronic file data on demographics, surgical procedure icpm code, duration of procedure, american society of anesthesiologists (asa) score, body mass index, comorbidity icd codes, and wound class of all patients undergoing surgery. nested case-control population: for patients establishing s. aureus ssi and 1:1 matched controls from the same center further data will be captured: length of hospitalization, length of icu stay and reason as well as attribution to ssi, survival at 30 and at 90 days, antibiotic treatments including duration, functional status at admission and at final discharge; necessity for surgical revision, and death attributed to ssi. if readmission is necessary, reason and attribution to ssi, length of hospitalization and length of icu stay as well as all antibiotic treatments and their duration will be recorded. the cases causative pathogens including resistance patterns and type of ssi according to cdc criteria will be captured. matching criteria comprise the following: * type of procedure * age * asa score * bmi * duration of procedure (as percentile for this procedure) * diabetes * sex


Eligibility criteria:
inclusion criteria: * age ≥18 years at the time of surgery exclusion criteria: * cases with missing data defined as "missing completely at random" (mcar) * infection at the time of surgery
biomechanical changes in women with chronic pelvic pain

Conditions: Pelvic Pain

Summary: chronic pelvic pain (cpp), a frequent complaint in clinical gynaecology, is defined as cyclic or acyclic pain located in the pelvis, persisting for 6 months or more, and severe enough to cause functional incapacity that requires medical or surgical treatment (or both). chronic pelvic pain is the reason for approximately 10% of all gynaecologic consultations

women who showed an imbalance of the pelvis also experienced greater pain. a possible explanation for this is that the change in the position of the uterus, due to the imbalance of the pelvis, prompted an excessive amount of prostaglandin to be secreted. when the spinal alignment of women who had intense menstrual pain was put back to normal, the pain was alleviated. the level of tension in the ligaments and nerves connecting the sacral vertebrae and the uterus is the cause off the menstrual pain. due to the abnormal restriction of movement of the lumbosacral vertebrae, body fluid increase within the pelvis as wells contraction of the uterus leading to the intensification of the menstrual pain. stabilization of anterior and lateral pelvic curves through exercise or osteopathic manipulative techniques that utilizes techniques of muscle energy, balanced ligamentous tension, myofascial release, strain and counterstrain to assist muscles to keep the spine upright and sufficiently flexible to support good posture . correct posture involves a straight spine, which maintains the natural curve of the spine in the human body. correct posture minimizes the strain on the human body by maintaining balance of the muscles and skeleton. this balanced musculoskeletal state protects the supporting structures in the body and prevents damage or progressive deformation in all positions, including standing, lying down, and sitting. additionally, correct posture implies not inclining the body forward, backward, left, or right. the temporomandibular joint is surrounded by ligaments, muscles, nerves, and blood vessels. the masticatory muscles enable mouth opening and closing, lateral movement, and forward and backward movement of the mouth, and excessive tension or imbalance of muscles can limit the joint movements, possibly resulting in limited rom. thus, it can be surmised that the imbalance in the spinal muscles caused the imbalance in the temporomandibular muscles and limited tmj mobility.

Eligibility criteria:
inclusion criteria: * the age of the participants will be ranged from 20 to 40 years. * their body mass index will be ranged from 20 to 25 kg/m2. * they will have regular menstrual cycle. * they will not receive any hormonal therapy or taking any regular drugs. exclusion criteria: * bone disease. * discogenic state with radiculopathy or not. * systemic disease of musculoskeletal system. * any sensory problems. * previous vertebral fractures. * major spinal structural abnormality. * major jaw abnormality. * any jaw orthotics or prosthesis. * missing teeth.
trial of decitabine in patients with acute myeloid leukemia

Conditions: Acute Myeloid Leukemia

Summary: the purpose of this study is to compare the results in older patients who have newly diagnosed or secondary acute myeloid leukemia (aml) and who are to either receive decitabine or patient's choice with the physician's advice of either cytarabine or supportive care medication.


Eligibility criteria:
inclusion criteria: 1. must have diagnosed acute myeloid leukemia. 2. must have a life expectancy of at least 12 weeks. 3. must sign informed consent. exclusion criteria: 1. must not have acute promyelocytic leukemia (m3 classification) 2. must not have any other active systemic malignancies. 3. must not have inaspirable bone marrow. 4. must not have received previous chemotherapy (except hydroxyurea) for any myeloid disorder. 5. must not have chronic respiratory disease that requires continuous oxygen use. 6. must not have received any experimental drug within 4 weeks before randomization. 7. must not be a candidate for a bone marrow or stem cell transplant within 12 weeks after randomization. 8. must not have known hiv.

Keywords: acute myeloid leukemia dacogen decitabine poor or intermediate-risk cytogenetics
long acting insulin versus multiple dose regimen for control of gestational diabetes mellitus

Conditions: Long Acting Insulin in Control of Gestational Diabetes Mellitus

Summary: multiple dose regimen as a standard treatment for gestational diabetes will be compared to long acting insulin


Eligibility criteria:
inclusion criteria: * pregnant women with gestational diabetes mellitus * between 24-28 weeks gestation exclusion criteria: * other endocrinological abnormalities
brain function and structure in cocaine dependence

Conditions: Cocaine Dependence

Summary: the purpose of this study is to examine the role of brain mri findings in predicting treatment outcomes among individuals with cocaine dependence.

the specific aims of this project are: aim 1: to determine whether pretreatment brain activation on fmri while performing a go-nogo task predicts response to pharmacotherapy in cocaine dependent subjects. hypothesis related to aim 1: pretreatment fmri bold activation in cocaine dependent subjects during impulsive responding on the go-nogo task predicts 8-week outcome from medication known to enhance serotonin function (citalopram). the regression coefficient of tes on pretreatment mean bold activation on the go-nogo task will be significantly greater for the citalopram group than the placebo group. aim 2: to determine whether pretreatment brain activation on fmri while performing an attentional bias (cocaine stroop) task predicts response to pharmacotherapy in cocaine dependent subjects. hypothesis related to aim 2: pretreatment fmri bold activation in cocaine dependent subjects during cocaine related words on the cocaine stroop task predicts 8-week outcome from medication known to enhance serotonin function (citalopram). the regression coefficient of tes on pretreatment mean bold activation from the cocaine stroop task will be significantly greater for the citalopram group than the placebo group.

Eligibility criteria:
inclusion criteria: * male and female subjects age 18 to 50 who meet current dsm-iv criteria for cocaine dependence who are seeking treatment. exclusion criteria: 1. current dsm-iv diagnosis of any psychoactive substance dependence other than cocaine, marijuana, nicotine, or alcohol 2. have a dsm-iv axis i psychiatric disorder or neurological disease or disorder requiring ongoing treatment and/or making study participation unsafe 3. significant current suicidal or homicidal ideation 4. medical conditions contraindicating citalopram pharmacotherapy (liver disease, seizure disorder, bleeding disorder, or prolonged qt interval on ekg) 5. taking cns active concomitant medications 6. taking medications known to have significant drug interactions with the study medication 7. having conditions of probation or parole requiring reports of drug use to officers of the court 8. impending incarceration 9. pregnant or breast feeding for female patients 10. inability to read, write, or speak english 11. having plans to leave the immediate geographical area within 3 months 12. unwillingness or not competent to sign a written informed consent form 13. individuals who have pacemakers, metal or electromechanical implants or metallic foreign bodies 14. patients who are known to be hiv positive will not be included due to possible cns effects of hiv. 15. alcohol withdrawal symptoms or history of significant previous alcohol withdrawal symptoms.

Keywords: substance abuse cocaine impulsivity serotonin mri
frequency of glucose monitoring in labor

Conditions: Neonatal Hypoglycemia

Summary: the aim of this study is to assess rates of neonatal hypoglycemia with differing intrapartum glucose protocols. currently at this time there is no guidance from professional medical organizations about when and how frequent to assess maternal glucose levels intrapartum. several institutions have no protocols in place. the study will be a randomized controlled trial placing patients with gestational diabetes mellitus (gdm) in "frequent" vs "infrequent" glucose monitoring intrapartum and assessing neonatal glucose levels at birth.


Eligibility criteria:
inclusion criteria: * all female patients of reproductive age who have the diagnosis gdm * patient with singleton gestation presenting in labor or for induction exclusion criteria: * patients below the age of 18 * multiple gestation pregnancy * patients undergoing scheduled c-section
long-term cardiac monitoring in epilepsy

Conditions: Focal Epilepsy; Intractable Epilepsy; Epileptic Encephalopathy; Lennox Gastaut Syndrome; Symptomatic Epilepsy; Generalized Epilepsy

Summary: the purpose of this research study to investigate, classify, and quantify chronic cardiac rhythm disorders in three groups of patients with epilepsy (intractable focal epilepsy, controlled focal epilepsy and symptomatic generalized epilepsy). patients with epilepsy have a higher risk for cardiac complications than the general population. with this study, we aim to understand more about these potential complications in patients with epilepsy and assess if treatments for cardiac problems should be evaluated more carefully in patients with epilepsy.

most cardiac studies have investigated patients with intractable focal epilepsy who have a high risk for co-morbidities, accidents, injury and sudep. this is confounded by the major antiepileptic drug burden in this population. very little, however, is known about the risk of cardiac arrhythmias in patients with a lower seizure burden, i.e. patients with infrequent focal seizures and/or those without secondarily generalized convulsions. furthermore, no chronic cardiac data is available in patients with epileptic encephalopathies especially given the fact that some of these patients are known to carry mutations that increase the risk for cardiac arrhythmias.in addition, periods of reduced cerebral blood flow during tachy or brady arrhythmias may exacerbate seizure severity and during. diagnosing and treating these arrhythmias may not only prevent adverse cardiac events, but also reduce seizure burden. this study primarily aims to compare the frequency of cardiac rhythm abnormalities in patients with epilepsy of different severity, assess the long-term cardiac risk and evaluate the possible preventive role of anti-arrhythmic agents and/or cardiac pacemaker/defibrillator needs.

Eligibility criteria:
inclusion criteria: 1. age 18-50 years with ability to consent. 2. no primary cardiac abnormality. 3. ability to receive an implantable loop recorder and tolerate the procedure. 4. patients with epilepsy as described by the three groups (intractable focal epilepsy, controlled focal epilepsy and symptomatic generalized epilepsy) exclusion criteria: 1. cardiac disease of any type 2. known epilepsy genetic disorder with potential cardiac compromise 3. major co-morbidities such as cancer, diabetes, stroke, bleeding disorder 4. chronic psychosis 5. severe mr without reliable caregiver monitoring (what is mr?) 6. already included in another clinical trial that will affect the objectives of this study. 7. life expectancy is less than 1 year