Kornimate/medical-research-clean huggingface dataset:
enhancing support for women with type 2 diabetes: follow-up

Conditions: Type 2 Diabetes Mellitus

Summary: this study is a 5-year continuation of "the mediterranean lifestyle program." the purpose of this follow-up study is to determine the long-term effects from prior participation in an intervention promoting healthful eating, exercise, quitting smoking, stress management, and social support. participants are post-menopausal women with type 2 diabetes.

coronary heart disease (chd) is the leading cause of death and functional limitations among women in the u.s. postmenopausal women with diabetes are at especially high risk of chd, but chd research with this population is very limited. this project addresses the poorly understood "natural history" of long-term maintenance of change in multiple behaviors (i.e., dietary, physical activity, social support, smoking cessation, and stress management) related to chd risk, as well as the effects of theoretically important mediating variables on relapse and maintenance. the study is a continuation of a research project that has already demonstrated significant and consistent positive effects of a lifestyle change intervention on reduction of behavioral chd risk factors. this research relies on a framework that synthesizes social-cognitive, social-ecologic, and goal-systems theories.

Eligibility criteria:
inclusion criteria: all participants in the original study are eligible. the inclusion criteria for the original study were: * diagnosis of type 2 diabetes for at least 6 months * being post-menopausal * living independently (e.g., not in an institution or nursing home) * having a telephone * ability to read english * not being developmentally disabled, and * living within 30 miles of the eugene-springfield metropolitan area. exclusion criteria: exclusion criteria for the original study included: * being older than 75 years of age * having life-threatening illnesses, or * planning to move from the local area within the time span of the study.

Keywords: type 2 diabetes mellitus coronary disease
two approaches to providing hiv/aids services in the community to people living with hiv/aids

Conditions: HIV Infection

Summary: this study will examine the effects of having a case manager help phas access and use health, social services and practical resources that are helpful to their needs as compared to the usual more pha self-managed approach of deciding and using services as they see necessary. new and existing users of hiv/aids services in wellington-dufferin, waterloo and grey-bruce regions who consent to this study will be randomized to receive their usual self-directed supportive, educational, medical and medical care services when they seek assistance according to their needs or these usual services augmented by case management services. they will be measured before randomization and at 3, 6 and 12 months following service use for their satisfaction with hiv/aids services, compliance with hiv/aids medication, improvement in quality of life, psychological distress, risk behaviours and expenditures for the use of a range of publicly funded services.


Eligibility criteria:
inclusion criteria: * hiv-positive individuals * living in the community setting exclusion criteria: * cognitive impairment

Keywords: people living with hiv quality of life
dexlansoprazole mr in nonerosive reflux disease

Conditions: Nonerosive Reflux Disease

Summary: this study aim is to compare the efficacy of dexlansoprazole mr intake before and after breakfast in patients with nonerosive reflux disease.


Eligibility criteria:
inclusion criteria: * nerd confirmed by gastroscopy exclusion criteria: * ppi medication within 2 weeks before enrollment
efficacy of proficiency-based versus free laparoscopic training in cholecystectomy on a virtual reality simulator

Conditions: Cholelithiasis; Cholecystitis; Cholecystolithiasis

Summary: virtual reality devices are widely accepted tools to familiarize surgical novices with the principles of laparoscopy. free virtual reality training will be tested against basic training and efficacy assessed in a randomized controlled trial of surgical novices.

virtual reality simulators are widely accepted tools to familiarize surgical novices with the principles of laparoscopy without jeopardizing patient safety. however, access to a virtual reality simulator and initial instruction alone followed by free training of the surgical novice may not be sufficient to achieve the training goals efficiently. the aims of this study are to determine if proficiency based laparoscopic training on the simbionx lap mentor™ with external formative assessment using peer group derived benchmarks is superior to free training with self-assessment using the simulated laparoscopic cholecystectomy procedure with different endpoints (time to extract the gallbladder, serious complications, safe cautery and instrument pathways) as outcome parameters.

Eligibility criteria:
inclusion criteria: * surgical novices (trainees / residents) * performed less than five laparoscopic procedures * no previous simulator experience exclusion criteria: * specialist surgeons * performed more than five laparoscopic procedures * previous experience with a simulator

Keywords: cholecystectomy virtual reality device training
the impact of intraoperative change in the body temperature on the perfusion index

Conditions: Perfusion Index; Hypothermia; Anesthesia

Summary: the goal of this observational study is to learn about the impact of intraoperative change in temperature in adult patients undergoing surgeries under general anaesthesia. the main question it aims to answer is: is the change in core body temperature reflected by changes in the prfusion index? patients' core temperature, peripheral temperature and perfusion indices will be recorded throughout the span of the procedure.

perioperative hypothermia increases the risk of postoperative morbidity and mortality. almost 50-90% of the patients experience perioperative hypothermia. this involves a decrease in core temperature to ≤ 36°c, which results in an increased rate of surgical site infection, haemorrhagic tendency, and ischemic heart disease, making it a serious perioperative complication. early hypothermia during general anaesthesia is mainly caused by the redistribution of body heat from the central to peripheral compartments, due to vasodilation following use of the anaesthetics. the degree of redistribution of body heat may be affected by the peripheral perfusion state, which differs across patients and results in a difference in gradient between temperature of the central and peripheral compartments. low peripheral perfusion state can lead to low peripheral body temperature, thus lowering the overall core body temperature. it was previously reported that the risk factors for intraoperative hypothermia are age, bmi, preoperative systolic blood pressure, heart rate, baseline core temperature, asa-ps score, the type of anaesthesia and surgery, the duration of preparation and surgery, and ambient temperature. previous studies did not include the pi as a risk factor for intraoperative hypothermia. therefore, further studies are needed to assess the relationship between pi and hypothermia to generate a more accurate predictive score of perioperative hypothermia.

Eligibility criteria:
inclusion criteria: * patients undergoing elective surgery under general anaesthesia * patients aged between 20 and 70 years old. exclusion criteria: * patients who decline to give a written informed consent. * patients with psychiatric disorders that lead to inability to cooperate, speak, or read. * bmi between \ 35 kg/m2. * patients undergoing emergency surgeries. * patients with peripheral vascular disease or rheumatoid disease.

Keywords: cross sectional observational hypothermia anaesthesia anesthesia general anaesthesia general anesthesia general surgery
prepulse inhibition of startle in cocaine dependence - 7

Conditions: Cocaine-Related Disorders; Substance-Related Disorders

Summary: the purpose of this study is to assess the effects of chronic cocaine use on the acoustic startle response and on gating of this response in humans.

the objective of this study is to assess the effects of chronic cocaine use on the acoustic startle response and on gating of this response in humans.

Eligibility criteria:
inclusion criteria: cocaine dependence. male. right handed. negative urine for cocaine exclusion criteria: positive urine for cocaine. history of head trauma. significant medical disease.

Keywords: cocaine dependence
eicosapentaenoic acid cerebral vasospasm therapy study

Conditions: Subarachnoid Hemorrhage; Cerebral Vasospasm

Summary: cerebral vasospasm following subarachnoid hemorrhage (sah) is the most common cause of morbidity and mortality. recent studies indicate that rho-kinase play an important role in the occurrence of such cerebral vasospasm. eicosapentaenoic acid (epa) inhibits sphingosylphosphorylcholine (spc)-induced rho-kinase activation in vitro. so this study examines whether epa prevents cerebral vasospasm occurrence after sah in patients.

cerebral vasospasm occasionally seen after subarachnoid hemorrhage (sah) due to a ruptured intracranial aneurysm is the most common cause of morbidity and mortality in these cases. recent studies indicate that rho-kinase plays an important role in such cerebral vasospasm and that numerous agents, such as thromboxane a2 (txa2), sphingosylphosphorylcholine (spc) and arachidonic acid (aa), can activate rho-kinase directly or through receptors in the cell membrane; among these agents, spc has been described as a novel messenger for rho-kinase-mediated ca2+ sensitization of vascular smooth muscle contraction. eicosapentaenoic acid (epa) has recently been reported to inhibit spc-induced rho-kinase activation in vitro, and thereby vascular smooth muscle contraction, through the inhibition of src family protein tyrosine kinases translocation. moreover, the concentration of aa increases in the cerebrospinal fluid of patients with sah, suggesting that this substance has a potential role in the occurrence of cerebral vasospasm following sah, while epa is known to change the constitution ratios of aa and epa in cell membrane phospholipid, resulting in the inhibition of txa2 synthesis. these observations lead us to hypothesize that epa may inhibit cerebral vasospasm following sah through the inhibition of rho-kinase activation.

Eligibility criteria:
inclusion criteria: * subarachnoid hemorrhage (sah) * the ruptured cerebral aneurysms conformed by cerebral angiography * the patients with treated by craniotomy and clip application within 72h after the onset of sah exclusion criteria: * traumatic or mycotic aneurysms * a history or complication of serious stroke * moya moya disease * a history of sah * complication of serious heart or hepatic disease or infection or renal failure * malignant tumor * patients judged to be inappropriate by physician in charge

Keywords: subarachnoid hemorrhage cerebral vasospasm eicosapentaenoic acid
transcribe (transcriptomic analysis of left ventricular gene expression)

Conditions: Cardiovascular Diseases

Summary: hypothesis: the investigators hypothesize that genetic variants will alter gene expression in response to ischemia during cardiopulmonary bypass. to test this, the investigators will be taking small pieces of heart tissue from patients undergoing heart surgery before and after this period of ischemia. this will be compared to blood gene expression in blood cells and analyzed with the patients' genetic profile. this might allow us to assess the amount of inflammation that occurs when patients are on the heart-lung machine as well as examine the effects genes have on this critical time period.


Eligibility criteria:
inclusion criteria: * aged greater than 20 years * undergoing aortic valve surgery with or without cabg surgery * receive and apical vent as part of the surgery exclusion criteria: * will not receive an apical left ventricular vent
pemetrexed in maintenance in patients with impaired renal function, 2 dose calculation strategies

Conditions: Non-small Cell Lung Cancer

Summary: pemetrexed is used in the treatment of non-small cell lung cancer (nsclc). its elimination is mainly renal and its nephrotoxicity requires an interruption of treatment when the crclcg falls below 45 ml / min. patients with nsclc frequently have impaired renal function by other cytotoxic drugs. the dose adjustment of pemetrexed is performed as a function of body surface area (sc) without any pharmacokinetic rational. the challenge is to treat patients with renal insufficiency (rr) with a safe dose, based on crcl, providing equivalent biological exposure to patients with preserved renal function.

* primary objective: evaluate the impact of calculating the dose of pemetrexed to be administered versus creatine clearance according to cockcroft-gault (crclcg) versus body surface area (sc) on median time before discontinuation of treatment for renal function ≤ 45ml / min in patients treated for non-small cell lung cancer predominantly non-squamous in maintenance. * secondary objective: to evaluate the impact of calculating the dose of pemetrexed to be administered versus crclcg versus sc over time to treatment discontinuation, progression-free survival (pfs), and patient overall survival.

Eligibility criteria:
inclusion criteria: * patient over 18 years of age * patient with non-small cell lung cancer predominantly non-epidermoid histologically documented * patient who is scheduled to initiate treatment or undergoing maintenance therapy by pemetrexed * neutrophils\> 1500 / mm3; chips\> 100,000 / mm3 * informed, dated and signed consent for patients of childbearing age, effective contraceptive method * creatinine clearance according to the cockcroft-gault formula between 70 and 45 ml / min * ps = 0 or 1 exclusion criteria: * patient with a contraindication to pemetrexed therapy * patient with symptomatic brain metastases * pregnant or nursing women * patient under guardianship or curatorship or subject to a system of protection for persons of full age * patient not affiliated to a social security scheme (beneficiary or beneficiary)

Keywords: pemetrexed non-small cell lung cancer clearance of creatine
the impact of ezetimibe on biochemical markers of cardiovascular risk in kidney transplant patients

Conditions: Dyslipidemia; Transplants

Summary: in kidney transplant patients atherosclerosis process is accelerated even in asymptomatic patients. this is mainly the consequence of immunosuppressive therapy. dyslipidemia is treated with statins in low doses only as high doses can lead to rhabdomyolysis and are therefore contraindicated. as second lipid lowering agent most commonly ezetimibe is used. the investigators hypothesise that ezetimibe as a second lipid lowering drug in kidney transplant patients lowers ldl cholesterol for additional 10 per cent.

in addition to observing the lipid profile the investigators intend to look for other pathophysiological effects of ezetimibe, such as its influence on oxidative stress, endothelial function and inflammatory biochemical markers.

Eligibility criteria:
inclusion criteria: ldl \> 2.5 mm, already treated with statin, stable renal function of various gfr, men or women older than 18 years, signed informed consent. exclusion criteria: acute heart disease or any heart disease in the last 3 months, kidney graft failure, active systemic inflammatory disease, active malignant disease, chronic diarrhea and malabsorption, transaminases increased \> 3 fold, creatin kinase increased \> 5 fold, hypersensitivity reactions, active peptic ulcer disease.
study of olanzapine vs. aripiprazole in the treatment of schizophrenia

Conditions: Schizophrenia

Summary: the purpose of the protocol is to evaluate the efficacy of olanzapine compared with aripiprazole in patients with schizophrenia.


Eligibility criteria:
inclusion criteria: * male or female inpatient or outpatients, ages 18-65 exclusion criteria: * participation in a clinical trial of another drug including olanzapine or aripiprazole within 30 days prior to study entry (visit 1). * treatment with clozapine within the past 12 months. * have known uncorrected narrow-angle glaucoma. * have a diagnosis of parkinson's disease, dementia or related disorder
the effect of painting therapy in children

Conditions: Child Development; Art Therapy

Summary: this study was designed to examine the effect of picture supported art therapy on visual perception, hand functions, participation and quality of life of children in healthy children.

it is planned that at least 25 children in each group will participate in the study. for both the control group and the study group, the sample of the study will consist of children between the ages of 6-12 who do not have any known disease/disability and show typical development, who voluntarily agree to participate in our study and sign the consent form. in addition, children in the control group should not have participated in any art course.sociodemographic information will be asked first in the evaluation of the individuals in the study. then, which hand of the children is dominant will be determined with edinburg hand preference questionnaire. visual perception of the children will be evaluated with the shape-ground subtest of the ayres southern california sensory integrity test, hand skills will be evaluated with the 9-hole peg test and the sense of kinesthesia in their fingers will be evaluated with the kinesthesia subtest of the ayres southern california sensory integrity test. children's quality of life will be assessed with the young child quality of life questionnaire in accordance with their age. the child and adolescent participation questionnaire will be given to the parents to question the social participation of the children and the conners parent rating scale will be given to the parents to evaluate the disruptive behaviour disorders. initial assessments will be made both in the study group and in the control group.the children in the study group will receive painting and drawing-based art therapy for 4 weeks, 2 days a week for 1 hour. after 4 weeks, all evaluations will be repeated.

Eligibility criteria:
inclusion criteria: * the sample of the study for both the control group and the study group, * to be between 6-12 years old, * not having any known illness/disability * voluntarily agree to participate in our study * the children in the control group should not have participated in any art course. exclusion criteria: * the sample of the study for both the control group and the study group, * not to be between 6-12 years old * having any known illness/disability (such as neurological, mental illness) * not voluntarily agreeing to participate in our study * children in the control group participated in any art course

Keywords: art therapy visual perception hand skills
behavioral economic purchasing decisions for cigarettes of varied compositions

Conditions: Tobacco Use Disorder; Substance-Related Disorders

Summary: the purpose of this study is to determine whether the abuse liability of cigarettes with altered composition (cigarettes differing in composition; e.g., tar levels, amount of sugar, casings) is reduced relative to standard composition cigarettes.

the proposed study will determine the abuse liability of altered composition cigarettes compared to standard cigarettes using a behavioral economics abuse-liability approach. behavioral economic demand analysis constitutes a comprehensive examination of drug reinforcement and abuse liability. laboratory determination of cigarette consumption under various response requirements will occur before and after 3 weeks of at-home exposure, with participants randomized to cigarettes varying in composition to determine the role of experience on the abuse-liability of various cigarettes. abuse liability will be assessed by 2 essential demand metrics: lower demand intensity and increased demand elasticity, as well as other demand metrics and subjective ratings of "liking". the study will also determine the degree to which altered composition cigarettes may substitute for standard composition cigarettes - testing whether an altered composition policy would achieve the goal of reducing standard cigarette consumption.

Eligibility criteria:
inclusion criteria: 1. age 18 years or older 2. smoke at least five cigarettes per day 3. have an expired carbon monoxide level of more than 8 ppm or a urinary cotinine level of more than 100 ng per milliliter 4. have a fagerström test for nicotine dependence score of at least 5 upon screening exclusion criteria: 1. the intention to quit smoking in the next 30 days 2. the use of other tobacco products in addition to machine-manufactured cigarettes on more than 9 of the previous 30 days 3. use of "roll your own" cigarettes as an exclusive form of smoking 4. a serious medical or psychiatric disorder or unstable condition 5. any positive toxicological screening for illicit drugs other than cannabis will be excluded 6. women who are pregnant, plan to become pregnant or are breast-feeding

Keywords: tobacco withdrawal autonomic agents
prolongation of pain free time by the use of dexamethasone in peripheral nerve blockade

Conditions: Interscalene Block; Shoulder Arthroscopy; Dexamethasone; Low Volume Regional Anesthesia

Summary: the main aim of the study is to investigate the proven effect of dexamethsone on the duration of the interscalene block. the investigators try to define optimal dose and volume for ropivacaine, when used together with dexamethsone. the current literature uses often very high volumes of ropivacain when used together with dexamethasone. the investigators try to research the effect of using dexamethsone together with low volume, high concentration ropivacaine for interscalene blockade. the investigators' hypothesis is that dexamethasone has an positive effect on the pain free after used together with ropivacaine at the scalene block.


Eligibility criteria:
inclusion criteria: * atroscopy of the shoulder * repair of the rm exclusion criteria: * patient under 18 years * patient is fertile * chronic opiat use more than 30mg oxycodone per day * operations at the shoulder that involves the bone * usage of cortisone for more than 2 weeks * risk greater as asa iii * damage to nerves * neuropathy at the target arm